                         SEQUENCE LISTING

<110>  Chang, Yung
       Yan, Hao
 
<120>  MULTIFUNCTIONAL APTAMER-NUCLEIC ACID NANOSTRUCTURES FOR 
       TUMOR-TARGETED KILLING

<130>  09-824

<160>  61    

<170>  PatentIn version 3.5

<210>  1
<211>  3594
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (417)..(1310)

<400>  1
gtctatcagc gatttcatct tcaggcctgg actacaccac tcaccctccc agtgtgcttg       60

agaaacaaac tgcacccact gaactccgca gctagcatcc aaatcagccc ttgagatttg      120

aggccttgga gactcagatc ctgaacaaga gagaacaaaa tctctacttt gatggaactt      180

ccattctgtg gggaagagac tgacaataag caattaaata aataagaact cagcagtagg      240

ccttgcctca gatccaaggt cactcggaag aggccatgtc taccctcaat gacactcatg      300

gaggaaatgc tgagagaagc attcagatgc atgacacaag gtaagactgc caaaaatctt      360

gttcttgctc tcctcatttt gttatttgtt ttatttttag gagttttgag agcaaa atg      419
                                                              Met         
                                                              1           

aca aca ccc aga aat tca gta aat ggg act ttc ccg gca gag cca atg        467
Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro Met           
            5                   10                  15                    

aaa ggc cct att gct atg caa tct ggt cca aaa cca ctc ttc agg agg        515
Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg Arg           
        20                  25                  30                        

atg tct tca ctg gtg ggc ccc acg caa agc ttc ttc atg agg gaa tct        563
Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu Ser           
    35                  40                  45                            

aag act ttg ggg gct gtc cag att atg aat ggg ctc ttc cac att gcc        611
Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile Ala           
50                  55                  60                  65            

ctg ggg ggt ctt ctg atg atc cca gca ggg atc tat gca ccc atc tgt        659
Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile Cys           
                70                  75                  80                

gtg act gtg tgg tac cct ctc tgg gga ggc att atg tat att att tcc        707
Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile Ser           
            85                  90                  95                    

gga tca ctc ctg gca gca acg gag aaa aac tcc agg aag tgt ttg gtc        755
Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu Val           
        100                 105                 110                       

aaa gga aaa atg ata atg aat tca ttg agc ctc ttt gct gcc att tct        803
Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile Ser           
    115                 120                 125                           

gga atg att ctt tca atc atg gac ata ctt aat att aaa att tcc cat        851
Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser His           
130                 135                 140                 145           

ttt tta aaa atg gag agt ctg aat ttt att aga gct cac aca cca tat        899
Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro Tyr           
                150                 155                 160               

att aac ata tac aac tgt gaa cca gct aat ccc tct gag aaa aac tcc        947
Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn Ser           
            165                 170                 175                   

cca tct acc caa tac tgt tac agc ata caa tct ctg ttc ttg ggc att        995
Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly Ile           
        180                 185                 190                       

ttg tca gtg atg ctg atc ttt gcc ttc ttc cag gaa ctt gta ata gct       1043
Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile Ala           
    195                 200                 205                           

ggc atc gtt gag aat gaa tgg aaa aga acg tgc tcc aga ccc aaa tct       1091
Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys Ser           
210                 215                 220                 225           

aac ata gtt ctc ctg tca gca gaa gaa aaa aaa gaa cag act att gaa       1139
Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile Glu           
                230                 235                 240               

ata aaa gaa gaa gtg gtt ggg cta act gaa aca tct tcc caa cca aag       1187
Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro Lys           
            245                 250                 255                   

aat gaa gaa gac att gaa att att cca atc caa gaa gag gaa gaa gaa       1235
Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu Glu           
        260                 265                 270                       

gaa aca gag acg aac ttt cca gaa cct ccc caa gat cag gaa tcc tca       1283
Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser Ser           
    275                 280                 285                           

cca ata gaa aat gac agc tct cct taa gtgatttctt ctgttttctg             1330
Pro Ile Glu Asn Asp Ser Ser Pro                                           
290                 295                                                   

tttccttttt taaacattag tgttcatagc ttccaagaga catgctgact ttcatttctt     1390

gaggtactct gcacatacgc accacatctc tatctggcct ttgcatggag tgaccatagc     1450

tccttctctc ttacattgaa tgtagagaat gtagccattg tagcagcttg tgttgtcacg     1510

cttcttcttt tgagcaactt tcttacactg aagaaaggca gaatgagtgc ttcagaatgt     1570

gatttcctac taacctgttc cttggatagg ctttttagta tagtattttt ttttgtcatt     1630

ttctccatca acaaccaggg agactgcacc tgatggaaaa gatatatgac tgcttcatga     1690

cattcctaaa ctatcttttt tttattccac atctacgttt ttggtggagt cccttttgca     1750

tcattgtttt aaggatgata aaaaaaaata acaactaggg acaatacaga acccattcca     1810

tttatctttc tacagggctg acattgtggc acattcttag agttaccaca ccccatgagg     1870

gaagctctaa atagccaaca cccatctgtt ttttgtaaaa acagcatagc ttatacatgg     1930

acatgtctct gccttaactt ttcctaactc ccactctagg ctattgtttg catgtctacc     1990

tacttttagc cattatgcga gaaaagaaaa aaatgaccat agaaaatgcc accatgaggt     2050

gcccaaattt caaataataa ttaacattta gttatattta taatttccag atgacaaagt     2110

atttcatcaa ataacttcat ttgatgttcc atgatcaaga aagaatccct atctctattt     2170

tacaagtaat tcaaagaggc caaataactt gtaaacaaga aaaggtaact tgtcaacagt     2230

cataactagt aattatgaga gccttgtttc ataaccaggt cttcttactc aaatcctgtg     2290

atgtttgaaa taaccaaatt gtctctccaa tgtctgcata aactgtgaga gccaagtcaa     2350

cagcttttat caagaattta ctctctgacc agcaataaac aagcactgag agacacagag     2410

agccagattc agattttacc catggggata aaaagactca gactttcacc acatttggaa     2470

aactacttgc atcataaata tataataact ggtagtttat atgaagcaga cactaagtgc     2530

tatagacact ctcagaatat catacttgga aacaatgtaa ttaaaatgcc gaatctgagt     2590

caacagctgc cctacttttc aattcagata tactagtacc ttacctagaa ataatgttaa     2650

cctagggtga agtcactata atctgtagtc tattatttgg gcatttgcta catgatgagt     2710

gctgccagat tgtggcaggt aaagagacaa tgtaatttgc actccctatg atatttctac     2770

atttttagcg accactagtg gaagacattc cccaaaatta gaaaaaaagg agatagaaga     2830

tttctgtcta tgtaaagttc tcaaaatttg ttctaaatta ataaaactat ctttgtgttc     2890

ttttctgcaa cagatgattc caacatgggt gtttgtctat tcttctttac tcttgaaaca     2950

ttagaccatg ggaggctctt acagccttga gttgatattt atacaaccca aatctaggtt     3010

tgaacggtga ggtgtcaggt catcaaatat tcatgtctat atagtcttac acaggttctc     3070

aaaaaaaatg ttcatgggat aggtcattga taatggattc cttattctga gaactccaga     3130

cgactgaaat atatgagaga aggaaaagga catagtagga gcaggcctga gaaaaaaatg     3190

aaagtcagaa atctttaaaa aaatacaaga tcttatttct atcttatttt ttctcctctt     3250

ctgaaatata tatgaggatt cctctccaaa cccatggttt ctctaagaat tttgagtcat     3310

ttgtatgacc tcaaataatt agttttagct gacctcacat aactccttat aataggagac     3370

atctttaatg tctgctatta aagaaggatg aaaattccta tgaccttctc cccgattatc     3430

cctttggcaa tatagagtca aataataaca ttgaccaata gtaaacatgc tttgccaaga     3490

agtagaagat atattctcta gccttagttt ttcctcccaa tttgcatttt tgtaaaaata     3550

atgttgtatc cacaaaggaa ataaacttta aaaacccaag tgca                      3594


<210>  2
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Thr Pro Arg Asn Ser Val Asn Gly Thr Phe Pro Ala Glu Pro 
1               5                   10                  15      


Met Lys Gly Pro Ile Ala Met Gln Ser Gly Pro Lys Pro Leu Phe Arg 
            20                  25                  30          


Arg Met Ser Ser Leu Val Gly Pro Thr Gln Ser Phe Phe Met Arg Glu 
        35                  40                  45              


Ser Lys Thr Leu Gly Ala Val Gln Ile Met Asn Gly Leu Phe His Ile 
    50                  55                  60                  


Ala Leu Gly Gly Leu Leu Met Ile Pro Ala Gly Ile Tyr Ala Pro Ile 
65                  70                  75                  80  


Cys Val Thr Val Trp Tyr Pro Leu Trp Gly Gly Ile Met Tyr Ile Ile 
                85                  90                  95      


Ser Gly Ser Leu Leu Ala Ala Thr Glu Lys Asn Ser Arg Lys Cys Leu 
            100                 105                 110         


Val Lys Gly Lys Met Ile Met Asn Ser Leu Ser Leu Phe Ala Ala Ile 
        115                 120                 125             


Ser Gly Met Ile Leu Ser Ile Met Asp Ile Leu Asn Ile Lys Ile Ser 
    130                 135                 140                 


His Phe Leu Lys Met Glu Ser Leu Asn Phe Ile Arg Ala His Thr Pro 
145                 150                 155                 160 


Tyr Ile Asn Ile Tyr Asn Cys Glu Pro Ala Asn Pro Ser Glu Lys Asn 
                165                 170                 175     


Ser Pro Ser Thr Gln Tyr Cys Tyr Ser Ile Gln Ser Leu Phe Leu Gly 
            180                 185                 190         


Ile Leu Ser Val Met Leu Ile Phe Ala Phe Phe Gln Glu Leu Val Ile 
        195                 200                 205             


Ala Gly Ile Val Glu Asn Glu Trp Lys Arg Thr Cys Ser Arg Pro Lys 
    210                 215                 220                 


Ser Asn Ile Val Leu Leu Ser Ala Glu Glu Lys Lys Glu Gln Thr Ile 
225                 230                 235                 240 


Glu Ile Lys Glu Glu Val Val Gly Leu Thr Glu Thr Ser Ser Gln Pro 
                245                 250                 255     


Lys Asn Glu Glu Asp Ile Glu Ile Ile Pro Ile Gln Glu Glu Glu Glu 
            260                 265                 270         


Glu Glu Thr Glu Thr Asn Phe Pro Glu Pro Pro Gln Asp Gln Glu Ser 
        275                 280                 285             


Ser Pro Ile Glu Asn Asp Ser Ser Pro 
    290                 295         


<210>  3
<211>  4816
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (521)..(4198)

<400>  3
gttcccggat ttttgtgggc gcctgccccg cccctcgtcc ccctgctgtg tccatatatc       60

gaggcgatag ggttaaggga aggcggacgc ctgatgggtt aatgagcaaa ctgaagtgtt      120

ttccatgatc ttttttgagt cgcaattgaa gtaccacctc ccgagggtga ttgcttcccc      180

atgcggggta gaacctttgc tgtcctgttc accactctac ctccagcaca gaatttggct      240

tatgcctact caatgtgaag atgatgagga tgaaaacctt tgtgatgatc cacttccact      300

taatgaatgg tggcaaagca aagctatatt caagaccaca tgcaaagcta ctccctgagc      360

aaagagtcac agataaaacg ggggcaccag tagaatggcc aggacaaacg cagtgcagca      420

cagagactca gaccctggca gccatgcctg cgcaggcagt gatgagagtg acatgtactg      480

ttgtggacat gcacaaaagt gagtgtgcac cggcacagac atg aag ctg cgg ctc        535
                                            Met Lys Leu Arg Leu           
                                            1               5             

cct gcc agt ccc gag acc cac ctg gac atg ctc cgc cac ctc tac cag        583
Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu Arg His Leu Tyr Gln           
                10                  15                  20                

ggc tgc cag gtg gtg cag gga aac ctg gaa ctc acc tac ctg ccc acc        631
Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu Thr Tyr Leu Pro Thr           
            25                  30                  35                    

aat gcc agc ctg tcc ttc ctg cag gat atc cag gag gtg cag ggc tac        679
Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln Glu Val Gln Gly Tyr           
        40                  45                  50                        

gtg ctc atc gct cac aac caa gtg agg cag gtc cca ctg cag agg ctg        727
Val Leu Ile Ala His Asn Gln Val Arg Gln Val Pro Leu Gln Arg Leu           
    55                  60                  65                            

cgg att gtg cga ggc acc cag ctc ttt gag gac aac tat gcc ctg gcc        775
Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp Asn Tyr Ala Leu Ala           
70                  75                  80                  85            

gtg cta gac aat gga gac ccg ctg aac aat acc acc cct gtc aca ggg        823
Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr Thr Pro Val Thr Gly           
                90                  95                  100               

gcc tcc cca gga ggc ctg cgg gag ctg cag ctt cga agc ctc aca gag        871
Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu Arg Ser Leu Thr Glu           
            105                 110                 115                   

atc ttg aaa gga ggg gtc ttg atc cag cgg aac ccc cag ctc tgc tac        919
Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn Pro Gln Leu Cys Tyr           
        120                 125                 130                       

cag gac acg att ttg tgg aag gac atc ttc cac aag aac aac cag ctg        967
Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His Lys Asn Asn Gln Leu           
    135                 140                 145                           

gct ctc aca ctg ata gac acc aac cgc tct cgg gcc tgc cac ccc tgt       1015
Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg Ala Cys His Pro Cys           
150                 155                 160                 165           

tct ccg atg tgt aag ggc tcc cgc tgc tgg gga gag agt tct gag gat       1063
Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly Glu Ser Ser Glu Asp           
                170                 175                 180               

tgt cag agc ctg acg cgc act gtc tgt gcc ggt ggc tgt gcc cgc tgc       1111
Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly Gly Cys Ala Arg Cys           
            185                 190                 195                   

aag ggg cca ctg ccc act gac tgc tgc cat gag cag tgt gct gcc ggc       1159
Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu Gln Cys Ala Ala Gly           
        200                 205                 210                       

tgc acg ggc ccc aag cac tct gac tgc ctg gcc tgc ctc cac ttc aac       1207
Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala Cys Leu His Phe Asn           
    215                 220                 225                           

cac agt ggc atc tgt gag ctg cac tgc cca gcc ctg gtc acc tac aac       1255
His Ser Gly Ile Cys Glu Leu His Cys Pro Ala Leu Val Thr Tyr Asn           
230                 235                 240                 245           

aca gac acg ttt gag tcc atg ccc aat ccc gag ggc cgg tat aca ttc       1303
Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu Gly Arg Tyr Thr Phe           
                250                 255                 260               

ggc gcc agc tgt gtg act gcc tgt ccc tac aac tac ctt tct acg gac       1351
Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn Tyr Leu Ser Thr Asp           
            265                 270                 275                   

gtg gga tcc tgc acc ctc gtc tgc ccc ctg cac aac caa gag gtg aca       1399
Val Gly Ser Cys Thr Leu Val Cys Pro Leu His Asn Gln Glu Val Thr           
        280                 285                 290                       

gca gag gat gga aca cag cgg tgt gag aag tgc agc aag ccc tgt gcc       1447
Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys Ser Lys Pro Cys Ala           
    295                 300                 305                           

cga gtg tgc tat ggt ctg ggc atg gag cac ttg cga gag gtg agg gca       1495
Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu Arg Glu Val Arg Ala           
310                 315                 320                 325           

gtt acc agt gcc aat atc cag gag ttt gct ggc tgc aag aag atc ttt       1543
Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly Cys Lys Lys Ile Phe           
                330                 335                 340               

ggg agc ctg gca ttt ctg ccg gag agc ttt gat ggg gac cca gcc tcc       1591
Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp Gly Asp Pro Ala Ser           
            345                 350                 355                   

aac act gcc ccg ctc cag cca gag cag ctc caa gtg ttt gag act ctg       1639
Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln Val Phe Glu Thr Leu           
        360                 365                 370                       

gaa gag atc aca ggt tac cta tac atc tca gca tgg ccg gac agc ctg       1687
Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala Trp Pro Asp Ser Leu           
    375                 380                 385                           

cct gac ctc agc gtc ttc cag aac ctg caa gta atc cgg gga cga att       1735
Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val Ile Arg Gly Arg Ile           
390                 395                 400                 405           

ctg cac aat ggc gcc tac tcg ctg acc ctg caa ggg ctg ggc atc agc       1783
Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln Gly Leu Gly Ile Ser           
                410                 415                 420               

tgg ctg ggg ctg cgc tca ctg agg gaa ctg ggc agt gga ctg gcc ctc       1831
Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly Ser Gly Leu Ala Leu           
            425                 430                 435                   

atc cac cat aac acc cac ctc tgc ttc gtg cac acg gtg ccc tgg gac       1879
Ile His His Asn Thr His Leu Cys Phe Val His Thr Val Pro Trp Asp           
        440                 445                 450                       

cag ctc ttt cgg aac ccg cac caa gct ctg ctc cac act gcc aac cgg       1927
Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu His Thr Ala Asn Arg           
    455                 460                 465                           

cca gag gac gag tgt gtg ggc gag ggc ctg gcc tgc cac cag ctg tgc       1975
Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala Cys His Gln Leu Cys           
470                 475                 480                 485           

gcc cga ggg cac tgc tgg ggt cca ggg ccc acc cag tgt gtc aac tgc       2023
Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr Gln Cys Val Asn Cys           
                490                 495                 500               

agc cag ttc ctt cgg ggc cag gag tgc gtg gag gaa tgc cga gta ctg       2071
Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu Glu Cys Arg Val Leu           
            505                 510                 515                   

cag ggg ctc ccc agg gag tat gtg aat gcc agg cac tgt ttg ccg tgc       2119
Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg His Cys Leu Pro Cys           
        520                 525                 530                       

cac cct gag tgt cag ccc cag aat ggc tca gtg acc tgt ttt gga ccg       2167
His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val Thr Cys Phe Gly Pro           
    535                 540                 545                           

gag gct gac cag tgt gtg gcc tgt gcc cac tat aag gac cct ccc ttc       2215
Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr Lys Asp Pro Pro Phe           
550                 555                 560                 565           

tgc gtg gcc cgc tgc ccc agc ggt gtg aaa cct gac ctc tcc tac atg       2263
Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro Asp Leu Ser Tyr Met           
                570                 575                 580               

ccc atc tgg aag ttt cca gat gag gag ggc gca tgc cag cct tgc ccc       2311
Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala Cys Gln Pro Cys Pro           
            585                 590                 595                   

atc aac tgc acc cac tcc tgt gtg gac ctg gat gac aag ggc tgc ccc       2359
Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp Asp Lys Gly Cys Pro           
        600                 605                 610                       

gcc gag cag aga gcc agc cct ctg acg tcc atc atc tct gcg gtg gtt       2407
Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile Ile Ser Ala Val Val           
    615                 620                 625                           

ggc att ctg ctg gtc gtg gtc ttg ggg gtg gtc ttt ggg atc ctc atc       2455
Gly Ile Leu Leu Val Val Val Leu Gly Val Val Phe Gly Ile Leu Ile           
630                 635                 640                 645           

aag cga cgg cag cag aag atc cgg aag tac acg atg cgg aga ctg ctg       2503
Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr Met Arg Arg Leu Leu           
                650                 655                 660               

cag gaa acg gag ctg gtg gag ccg ctg aca cct agc gga gcg atg ccc       2551
Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro Ser Gly Ala Met Pro           
            665                 670                 675                   

aac cag gcg cag atg cgg atc ctg aaa gag acg gag ctg agg aag gtg       2599
Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr Glu Leu Arg Lys Val           
        680                 685                 690                       

aag gtg ctt gga tct ggc gct ttt ggc aca gtc tac aag ggc atc tgg       2647
Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val Tyr Lys Gly Ile Trp           
    695                 700                 705                           

atc cct gat ggg gag aat gtg aaa att cca gtg gcc atc aaa gtg ttg       2695
Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val Ala Ile Lys Val Leu           
710                 715                 720                 725           

agg gaa aac aca tcc ccc aaa gcc aac aaa gaa atc tta gac gaa gca       2743
Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu Ile Leu Asp Glu Ala           
                730                 735                 740               

tac gtg atg gct ggt gtg ggc tcc cca tat gtc tcc cgc ctt ctg ggc       2791
Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val Ser Arg Leu Leu Gly           
            745                 750                 755                   

atc tgc ctg aca tcc acg gtg cag ctg gtg aca cag ctt atg ccc tat       2839
Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr Gln Leu Met Pro Tyr           
        760                 765                 770                       

ggc tgc ctc tta gac cat gtc cgg gaa aac cgc gga cgc ctg ggc tcc       2887
Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg Gly Arg Leu Gly Ser           
    775                 780                 785                           

cag gac ctg ctg aac tgg tgt atg cag att gcc aag ggg atg agc tac       2935
Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala Lys Gly Met Ser Tyr           
790                 795                 800                 805           

ctg gag gat gtg cgg ctc gta cac agg gac ttg gcc gct cgg aac gtg       2983
Leu Glu Asp Val Arg Leu Val His Arg Asp Leu Ala Ala Arg Asn Val           
                810                 815                 820               

ctg gtc aag agt ccc aac cat gtc aaa att aca gac ttc ggg ctg gct       3031
Leu Val Lys Ser Pro Asn His Val Lys Ile Thr Asp Phe Gly Leu Ala           
            825                 830                 835                   

cgg ctg ctg gac att gac gag aca gag tac cat gca gat ggg ggc aag       3079
Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His Ala Asp Gly Gly Lys           
        840                 845                 850                       

gtg ccc atc aag tgg atg gcg ctg gag tcc att ctc cgc cgg cgg ttc       3127
Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile Leu Arg Arg Arg Phe           
    855                 860                 865                           

acc cac cag agt gat gtg tgg agt tat ggt gtg act gtg tgg gag ctg       3175
Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val Thr Val Trp Glu Leu           
870                 875                 880                 885           

atg act ttt ggg gcc aaa cct tac gat ggg atc cca gcc cgg gag atc       3223
Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile Pro Ala Arg Glu Ile           
                890                 895                 900               

cct gac ctg ctg gaa aag ggg gag cgg ctg ccc cag ccc ccc atc tgc       3271
Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro Gln Pro Pro Ile Cys           
            905                 910                 915                   

acc att gat gtc tac atg atc atg gtc aaa tgt tgg atg att gac tct       3319
Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys Trp Met Ile Asp Ser           
        920                 925                 930                       

gaa tgt cgg cca aga ttc cgg gag ttg gtg tct gaa ttc tcc cgc atg       3367
Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser Glu Phe Ser Arg Met           
    935                 940                 945                           

gcc agg gac ccc cag cgc ttt gtg gtc atc cag aat gag gac ttg ggc       3415
Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln Asn Glu Asp Leu Gly           
950                 955                 960                 965           

cca gcc agt ccc ttg gac agc acc ttc tac cgc tca ctg ctg gag gac       3463
Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg Ser Leu Leu Glu Asp           
                970                 975                 980               

gat gac atg ggg gac ctg gtg gat gct gag gag tat ctg gta ccc cag       3511
Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu Tyr Leu Val Pro Gln           
            985                 990                 995                   

cag ggc ttc  ttc tgt cca gac cct  gcc ccg ggc gct ggg  ggc atg        3556
Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly Ala Gly  Gly Met            
        1000                 1005                 1010                    

gtc cac cac  agg cac cgc agc tca  tct acc agg agt ggc  ggt ggg        3601
Val His His  Arg His Arg Ser Ser  Ser Thr Arg Ser Gly  Gly Gly            
        1015                 1020                 1025                    

gac ctg aca  cta ggg ctg gag ccc  tct gaa gag gag gcc  ccc agg        3646
Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu Glu Ala  Pro Arg            
        1030                 1035                 1040                    

tct cca ctg  gca ccc tcc gaa ggg  gct ggc tcc gat gta  ttt gat        3691
Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser Asp Val  Phe Asp            
        1045                 1050                 1055                    

ggt gac ctg  gga atg ggg gca gcc  aag ggg ctg caa agc  ctc ccc        3736
Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu Gln Ser  Leu Pro            
        1060                 1065                 1070                    

aca cat gac  ccc agc cct cta cag  cgg tac agt gag gac  ccc aca        3781
Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser Glu Asp  Pro Thr            
        1075                 1080                 1085                    

gta ccc ctg  ccc tct gag act gat  ggc tac gtt gcc ccc  ctg acc        3826
Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val Ala Pro  Leu Thr            
        1090                 1095                 1100                    

tgc agc ccc  cag cct gaa tat gtg  aac cag cca gat gtt  cgg ccc        3871
Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro Asp Val  Arg Pro            
        1105                 1110                 1115                    

cag ccc cct  tcg ccc cga gag ggc  cct ctg cct gct gcc  cga cct        3916
Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro Ala Ala  Arg Pro            
        1120                 1125                 1130                    

gct ggt gcc  act ctg gaa agg ccc  aag act ctc tcc cca  ggg aag        3961
Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu Ser Pro  Gly Lys            
        1135                 1140                 1145                    

aat ggg gtc  gtc aaa gac gtt ttt  gcc ttt ggg ggt gcc  gtg gag        4006
Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly Gly Ala  Val Glu            
        1150                 1155                 1160                    

aac ccc gag  tac ttg aca ccc cag  gga gga gct gcc cct  cag ccc        4051
Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala Ala Pro  Gln Pro            
        1165                 1170                 1175                    

cac cct cct  cct gcc ttc agc cca  gcc ttc gac aac ctc  tat tac        4096
His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp Asn Leu  Tyr Tyr            
        1180                 1185                 1190                    

tgg gac cag  gac cca cca gag cgg  ggg gct cca ccc agc  acc ttc        4141
Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro Pro Ser  Thr Phe            
        1195                 1200                 1205                    

aaa ggg aca  cct acg gca gag aac  cca gag tac ctg ggt  ctg gac        4186
Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr Leu Gly  Leu Asp            
        1210                 1215                 1220                    

gtg cca gtg  tga accagaaggc caagtccgca gaagccctga tgtgtcctca          4238
Val Pro Val                                                               
        1225                                                              

gggagcaggg aaggcctgac ttctgctggc atcaagaggt gggagggccc tccgaccact     4298

tccaggggaa cctgccatgc caggaacctg tcctaaggaa ccttccttcc tgcttgagtt     4358

cccagatggc tggaaggggt ccagcctcgt tggaagagga acagcactgg ggagtctttg     4418

tggattctga ggccctgccc aatgagactc tagggtccag tggatgccac agcccagctt     4478

ggccctttcc ttccagatcc tgggtactga aagccttagg gaagctggcc tgagagggga     4538

agcggcccta agggagtgtc taagaacaaa agcgacccat tcagagactg tccctgaaac     4598

ctagtactgc cccccatgag gaaggaacag caatggtgtc agtatccagg ctttgtacag     4658

agtgcttttc tgtttagttt ttactttttt tgttttgttt ttttaaagat gaaataaaga     4718

cccaggggga gaatgggtgt tgtatgggga ggcaagtgtg gggggtcctt ctccacaccc     4778

actttgtcca tttgcaaata tattttggaa aacagcta                             4816


<210>  4
<211>  1225
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Lys Leu Arg Leu Pro Ala Ser Pro Glu Thr His Leu Asp Met Leu 
1               5                   10                  15      


Arg His Leu Tyr Gln Gly Cys Gln Val Val Gln Gly Asn Leu Glu Leu 
            20                  25                  30          


Thr Tyr Leu Pro Thr Asn Ala Ser Leu Ser Phe Leu Gln Asp Ile Gln 
        35                  40                  45              


Glu Val Gln Gly Tyr Val Leu Ile Ala His Asn Gln Val Arg Gln Val 
    50                  55                  60                  


Pro Leu Gln Arg Leu Arg Ile Val Arg Gly Thr Gln Leu Phe Glu Asp 
65                  70                  75                  80  


Asn Tyr Ala Leu Ala Val Leu Asp Asn Gly Asp Pro Leu Asn Asn Thr 
                85                  90                  95      


Thr Pro Val Thr Gly Ala Ser Pro Gly Gly Leu Arg Glu Leu Gln Leu 
            100                 105                 110         


Arg Ser Leu Thr Glu Ile Leu Lys Gly Gly Val Leu Ile Gln Arg Asn 
        115                 120                 125             


Pro Gln Leu Cys Tyr Gln Asp Thr Ile Leu Trp Lys Asp Ile Phe His 
    130                 135                 140                 


Lys Asn Asn Gln Leu Ala Leu Thr Leu Ile Asp Thr Asn Arg Ser Arg 
145                 150                 155                 160 


Ala Cys His Pro Cys Ser Pro Met Cys Lys Gly Ser Arg Cys Trp Gly 
                165                 170                 175     


Glu Ser Ser Glu Asp Cys Gln Ser Leu Thr Arg Thr Val Cys Ala Gly 
            180                 185                 190         


Gly Cys Ala Arg Cys Lys Gly Pro Leu Pro Thr Asp Cys Cys His Glu 
        195                 200                 205             


Gln Cys Ala Ala Gly Cys Thr Gly Pro Lys His Ser Asp Cys Leu Ala 
    210                 215                 220                 


Cys Leu His Phe Asn His Ser Gly Ile Cys Glu Leu His Cys Pro Ala 
225                 230                 235                 240 


Leu Val Thr Tyr Asn Thr Asp Thr Phe Glu Ser Met Pro Asn Pro Glu 
                245                 250                 255     


Gly Arg Tyr Thr Phe Gly Ala Ser Cys Val Thr Ala Cys Pro Tyr Asn 
            260                 265                 270         


Tyr Leu Ser Thr Asp Val Gly Ser Cys Thr Leu Val Cys Pro Leu His 
        275                 280                 285             


Asn Gln Glu Val Thr Ala Glu Asp Gly Thr Gln Arg Cys Glu Lys Cys 
    290                 295                 300                 


Ser Lys Pro Cys Ala Arg Val Cys Tyr Gly Leu Gly Met Glu His Leu 
305                 310                 315                 320 


Arg Glu Val Arg Ala Val Thr Ser Ala Asn Ile Gln Glu Phe Ala Gly 
                325                 330                 335     


Cys Lys Lys Ile Phe Gly Ser Leu Ala Phe Leu Pro Glu Ser Phe Asp 
            340                 345                 350         


Gly Asp Pro Ala Ser Asn Thr Ala Pro Leu Gln Pro Glu Gln Leu Gln 
        355                 360                 365             


Val Phe Glu Thr Leu Glu Glu Ile Thr Gly Tyr Leu Tyr Ile Ser Ala 
    370                 375                 380                 


Trp Pro Asp Ser Leu Pro Asp Leu Ser Val Phe Gln Asn Leu Gln Val 
385                 390                 395                 400 


Ile Arg Gly Arg Ile Leu His Asn Gly Ala Tyr Ser Leu Thr Leu Gln 
                405                 410                 415     


Gly Leu Gly Ile Ser Trp Leu Gly Leu Arg Ser Leu Arg Glu Leu Gly 
            420                 425                 430         


Ser Gly Leu Ala Leu Ile His His Asn Thr His Leu Cys Phe Val His 
        435                 440                 445             


Thr Val Pro Trp Asp Gln Leu Phe Arg Asn Pro His Gln Ala Leu Leu 
    450                 455                 460                 


His Thr Ala Asn Arg Pro Glu Asp Glu Cys Val Gly Glu Gly Leu Ala 
465                 470                 475                 480 


Cys His Gln Leu Cys Ala Arg Gly His Cys Trp Gly Pro Gly Pro Thr 
                485                 490                 495     


Gln Cys Val Asn Cys Ser Gln Phe Leu Arg Gly Gln Glu Cys Val Glu 
            500                 505                 510         


Glu Cys Arg Val Leu Gln Gly Leu Pro Arg Glu Tyr Val Asn Ala Arg 
        515                 520                 525             


His Cys Leu Pro Cys His Pro Glu Cys Gln Pro Gln Asn Gly Ser Val 
    530                 535                 540                 


Thr Cys Phe Gly Pro Glu Ala Asp Gln Cys Val Ala Cys Ala His Tyr 
545                 550                 555                 560 


Lys Asp Pro Pro Phe Cys Val Ala Arg Cys Pro Ser Gly Val Lys Pro 
                565                 570                 575     


Asp Leu Ser Tyr Met Pro Ile Trp Lys Phe Pro Asp Glu Glu Gly Ala 
            580                 585                 590         


Cys Gln Pro Cys Pro Ile Asn Cys Thr His Ser Cys Val Asp Leu Asp 
        595                 600                 605             


Asp Lys Gly Cys Pro Ala Glu Gln Arg Ala Ser Pro Leu Thr Ser Ile 
    610                 615                 620                 


Ile Ser Ala Val Val Gly Ile Leu Leu Val Val Val Leu Gly Val Val 
625                 630                 635                 640 


Phe Gly Ile Leu Ile Lys Arg Arg Gln Gln Lys Ile Arg Lys Tyr Thr 
                645                 650                 655     


Met Arg Arg Leu Leu Gln Glu Thr Glu Leu Val Glu Pro Leu Thr Pro 
            660                 665                 670         


Ser Gly Ala Met Pro Asn Gln Ala Gln Met Arg Ile Leu Lys Glu Thr 
        675                 680                 685             


Glu Leu Arg Lys Val Lys Val Leu Gly Ser Gly Ala Phe Gly Thr Val 
    690                 695                 700                 


Tyr Lys Gly Ile Trp Ile Pro Asp Gly Glu Asn Val Lys Ile Pro Val 
705                 710                 715                 720 


Ala Ile Lys Val Leu Arg Glu Asn Thr Ser Pro Lys Ala Asn Lys Glu 
                725                 730                 735     


Ile Leu Asp Glu Ala Tyr Val Met Ala Gly Val Gly Ser Pro Tyr Val 
            740                 745                 750         


Ser Arg Leu Leu Gly Ile Cys Leu Thr Ser Thr Val Gln Leu Val Thr 
        755                 760                 765             


Gln Leu Met Pro Tyr Gly Cys Leu Leu Asp His Val Arg Glu Asn Arg 
    770                 775                 780                 


Gly Arg Leu Gly Ser Gln Asp Leu Leu Asn Trp Cys Met Gln Ile Ala 
785                 790                 795                 800 


Lys Gly Met Ser Tyr Leu Glu Asp Val Arg Leu Val His Arg Asp Leu 
                805                 810                 815     


Ala Ala Arg Asn Val Leu Val Lys Ser Pro Asn His Val Lys Ile Thr 
            820                 825                 830         


Asp Phe Gly Leu Ala Arg Leu Leu Asp Ile Asp Glu Thr Glu Tyr His 
        835                 840                 845             


Ala Asp Gly Gly Lys Val Pro Ile Lys Trp Met Ala Leu Glu Ser Ile 
    850                 855                 860                 


Leu Arg Arg Arg Phe Thr His Gln Ser Asp Val Trp Ser Tyr Gly Val 
865                 870                 875                 880 


Thr Val Trp Glu Leu Met Thr Phe Gly Ala Lys Pro Tyr Asp Gly Ile 
                885                 890                 895     


Pro Ala Arg Glu Ile Pro Asp Leu Leu Glu Lys Gly Glu Arg Leu Pro 
            900                 905                 910         


Gln Pro Pro Ile Cys Thr Ile Asp Val Tyr Met Ile Met Val Lys Cys 
        915                 920                 925             


Trp Met Ile Asp Ser Glu Cys Arg Pro Arg Phe Arg Glu Leu Val Ser 
    930                 935                 940                 


Glu Phe Ser Arg Met Ala Arg Asp Pro Gln Arg Phe Val Val Ile Gln 
945                 950                 955                 960 


Asn Glu Asp Leu Gly Pro Ala Ser Pro Leu Asp Ser Thr Phe Tyr Arg 
                965                 970                 975     


Ser Leu Leu Glu Asp Asp Asp Met Gly Asp Leu Val Asp Ala Glu Glu 
            980                 985                 990         


Tyr Leu Val Pro Gln Gln Gly Phe  Phe Cys Pro Asp Pro  Ala Pro Gly 
        995                 1000                 1005             


Ala Gly  Gly Met Val His His  Arg His Arg Ser Ser  Ser Thr Arg 
    1010                 1015                 1020             


Ser Gly  Gly Gly Asp Leu Thr  Leu Gly Leu Glu Pro  Ser Glu Glu 
    1025                 1030                 1035             


Glu Ala  Pro Arg Ser Pro Leu  Ala Pro Ser Glu Gly  Ala Gly Ser 
    1040                 1045                 1050             


Asp Val  Phe Asp Gly Asp Leu  Gly Met Gly Ala Ala  Lys Gly Leu 
    1055                 1060                 1065             


Gln Ser  Leu Pro Thr His Asp  Pro Ser Pro Leu Gln  Arg Tyr Ser 
    1070                 1075                 1080             


Glu Asp  Pro Thr Val Pro Leu  Pro Ser Glu Thr Asp  Gly Tyr Val 
    1085                 1090                 1095             


Ala Pro  Leu Thr Cys Ser Pro  Gln Pro Glu Tyr Val  Asn Gln Pro 
    1100                 1105                 1110             


Asp Val  Arg Pro Gln Pro Pro  Ser Pro Arg Glu Gly  Pro Leu Pro 
    1115                 1120                 1125             


Ala Ala  Arg Pro Ala Gly Ala  Thr Leu Glu Arg Pro  Lys Thr Leu 
    1130                 1135                 1140             


Ser Pro  Gly Lys Asn Gly Val  Val Lys Asp Val Phe  Ala Phe Gly 
    1145                 1150                 1155             


Gly Ala  Val Glu Asn Pro Glu  Tyr Leu Thr Pro Gln  Gly Gly Ala 
    1160                 1165                 1170             


Ala Pro  Gln Pro His Pro Pro  Pro Ala Phe Ser Pro  Ala Phe Asp 
    1175                 1180                 1185             


Asn Leu  Tyr Tyr Trp Asp Gln  Asp Pro Pro Glu Arg  Gly Ala Pro 
    1190                 1195                 1200             


Pro Ser  Thr Phe Lys Gly Thr  Pro Thr Ala Glu Asn  Pro Glu Tyr 
    1205                 1210                 1215             


Leu Gly  Leu Asp Val Pro Val  
    1220                 1225 


<210>  5
<211>  2560
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (262)..(2421)

<400>  5
ctcaaaaggg gccggatttc cttctcctgg aggcagatgt tgcctctctc tctcgctcgg       60

attggttcag tgcactctag aaacactgct gtggtggaga aactggaccc caggtctgga      120

gcgaattcca gcctgcaggg ctgataagcg aggcattagt gagattgaga gagactttac      180

cccgccgtgg tggttggagg gcgcgcagta gagcagcagc acaggcgcgg gtcccgggag      240

gccggctctg ctcgcgccga g atg tgg aat ctc ctt cac gaa acc gac tcg        291
                        Met Trp Asn Leu Leu His Glu Thr Asp Ser           
                        1               5                   10            

gct gtg gcc acc gcg cgc cgc ccg cgc tgg ctg tgc gct ggg gcg ctg        339
Ala Val Ala Thr Ala Arg Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu           
                15                  20                  25                

gtg ctg gcg ggt ggc ttc ttt ctc ctc ggc ttc ctc ttc ggg tgg ttt        387
Val Leu Ala Gly Gly Phe Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe           
            30                  35                  40                    

ata aaa tcc tcc aat gaa gct act aac att act cca aag cat aat atg        435
Ile Lys Ser Ser Asn Glu Ala Thr Asn Ile Thr Pro Lys His Asn Met           
        45                  50                  55                        

aaa gca ttt ttg gat gaa ttg aaa gct gag aac atc aag aag ttc tta        483
Lys Ala Phe Leu Asp Glu Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu           
    60                  65                  70                            

tat aat ttt aca cag ata cca cat tta gca gga aca gaa caa aac ttt        531
Tyr Asn Phe Thr Gln Ile Pro His Leu Ala Gly Thr Glu Gln Asn Phe           
75                  80                  85                  90            

cag ctt gca aag caa att caa tcc cag tgg aaa gaa ttt ggc ctg gat        579
Gln Leu Ala Lys Gln Ile Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp           
                95                  100                 105               

tct gtt gag cta gca cat tat gat gtc ctg ttg tcc tac cca aat aag        627
Ser Val Glu Leu Ala His Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys           
            110                 115                 120                   

act cat ccc aac tac atc tca ata att aat gaa gat gga aat gag att        675
Thr His Pro Asn Tyr Ile Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile           
        125                 130                 135                       

ttc aac aca tca tta ttt gaa cca cct cct cca gga tat gaa aat gtt        723
Phe Asn Thr Ser Leu Phe Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val           
    140                 145                 150                           

tcg gat att gta cca cct ttc agt gct ttc tct cct caa gga atg cca        771
Ser Asp Ile Val Pro Pro Phe Ser Ala Phe Ser Pro Gln Gly Met Pro           
155                 160                 165                 170           

gag ggc gat cta gtg tat gtt aac tat gca cga act gaa gac ttc ttt        819
Glu Gly Asp Leu Val Tyr Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe           
                175                 180                 185               

aaa ttg gaa cgg gac atg aaa atc aat tgc tct ggg aaa att gta att        867
Lys Leu Glu Arg Asp Met Lys Ile Asn Cys Ser Gly Lys Ile Val Ile           
            190                 195                 200                   

gcc aga tat ggg aaa gtt ttc aga gga aat aag gtt aaa aat gcc cag        915
Ala Arg Tyr Gly Lys Val Phe Arg Gly Asn Lys Val Lys Asn Ala Gln           
        205                 210                 215                       

ctg gca ggg gcc aaa gga gtc att ctc tac tcc gac cct gct gac tac        963
Leu Ala Gly Ala Lys Gly Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr           
    220                 225                 230                           

ttt gct cct ggg gtg aag tcc tat cca gat ggt tgg aat ctt cct gga       1011
Phe Ala Pro Gly Val Lys Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly           
235                 240                 245                 250           

ggt ggt gtc cag cgt gga aat atc cta aat ctg aat ggt gca gga gac       1059
Gly Gly Val Gln Arg Gly Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp           
                255                 260                 265               

cct ctc aca cca ggt tac cca gca aat gaa tat gct tat agg cgt gga       1107
Pro Leu Thr Pro Gly Tyr Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly           
            270                 275                 280                   

att gca gag gct gtt ggt ctt cca agt att cct gtt cat cca att gga       1155
Ile Ala Glu Ala Val Gly Leu Pro Ser Ile Pro Val His Pro Ile Gly           
        285                 290                 295                       

tac tat gat gca cag aag ctc cta gaa aaa atg ggt ggc tca gca cca       1203
Tyr Tyr Asp Ala Gln Lys Leu Leu Glu Lys Met Gly Gly Ser Ala Pro           
    300                 305                 310                           

cca gat agc agc tgg aga gga agt ctc aaa gtg ccc tac aat gtt gga       1251
Pro Asp Ser Ser Trp Arg Gly Ser Leu Lys Val Pro Tyr Asn Val Gly           
315                 320                 325                 330           

cct ggc ttt act gga aac ttt tct aca caa aaa gtc aag atg cac atc       1299
Pro Gly Phe Thr Gly Asn Phe Ser Thr Gln Lys Val Lys Met His Ile           
                335                 340                 345               

cac tct acc aat gaa gtg aca aga att tac aat gtg ata ggt act ctc       1347
His Ser Thr Asn Glu Val Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu           
            350                 355                 360                   

aga gga gca gtg gaa cca gac aga tat gtc att ctg gga ggt cac cgg       1395
Arg Gly Ala Val Glu Pro Asp Arg Tyr Val Ile Leu Gly Gly His Arg           
        365                 370                 375                       

gac tca tgg gtg ttt ggt ggt att gac cct cag agt gga gca gct gtt       1443
Asp Ser Trp Val Phe Gly Gly Ile Asp Pro Gln Ser Gly Ala Ala Val           
    380                 385                 390                           

gtt cat gaa att gtg agg agc ttt gga aca ctg aaa aag gaa ggg tgg       1491
Val His Glu Ile Val Arg Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp           
395                 400                 405                 410           

aga cct aga aga aca att ttg ttt gca agc tgg gat gca gaa gaa ttt       1539
Arg Pro Arg Arg Thr Ile Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe           
                415                 420                 425               

ggt ctt ctt ggt tct act gag tgg gca gag gag aat tca aga ctc ctt       1587
Gly Leu Leu Gly Ser Thr Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu           
            430                 435                 440                   

caa gag cgt ggc gtg gct tat att aat gct gac tca tct ata gaa gga       1635
Gln Glu Arg Gly Val Ala Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly           
        445                 450                 455                       

aac tac act ctg aga gtt gat tgt aca ccg ctg atg tac agc ttg gta       1683
Asn Tyr Thr Leu Arg Val Asp Cys Thr Pro Leu Met Tyr Ser Leu Val           
    460                 465                 470                           

cac aac cta aca aaa gag ctg aaa agc cct gat gaa ggc ttt gaa ggc       1731
His Asn Leu Thr Lys Glu Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly           
475                 480                 485                 490           

aaa tct ctt tat gaa agt tgg act aaa aaa agt cct tcc cca gag ttc       1779
Lys Ser Leu Tyr Glu Ser Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe           
                495                 500                 505               

agt ggc atg ccc agg ata agc aaa ttg gga tct gga aat gat ttt gag       1827
Ser Gly Met Pro Arg Ile Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu           
            510                 515                 520                   

gtg ttc ttc caa cga ctt gga att gct tca ggc aga gca cgg tat act       1875
Val Phe Phe Gln Arg Leu Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr           
        525                 530                 535                       

aaa aat tgg gaa aca aac aaa ttc agc ggc tat cca ctg tat cac agt       1923
Lys Asn Trp Glu Thr Asn Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser           
    540                 545                 550                           

gtc tat gaa aca tat gag ttg gtg gaa aag ttt tat gat cca atg ttt       1971
Val Tyr Glu Thr Tyr Glu Leu Val Glu Lys Phe Tyr Asp Pro Met Phe           
555                 560                 565                 570           

aaa tat cac ctc act gtg gcc cag gtt cga gga ggg atg gtg ttt gag       2019
Lys Tyr His Leu Thr Val Ala Gln Val Arg Gly Gly Met Val Phe Glu           
                575                 580                 585               

cta gcc aat tcc ata gtg ctc cct ttt gat tgt cga gat tat gct gta       2067
Leu Ala Asn Ser Ile Val Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val           
            590                 595                 600                   

gtt tta aga aag tat gct gac aaa atc tac agt att tct atg aaa cat       2115
Val Leu Arg Lys Tyr Ala Asp Lys Ile Tyr Ser Ile Ser Met Lys His           
        605                 610                 615                       

cca cag gaa atg aag aca tac agt gta tca ttt gat tca ctt ttt tct       2163
Pro Gln Glu Met Lys Thr Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser           
    620                 625                 630                           

gca gta aag aat ttt aca gaa att gct tcc aag ttc agt gag aga ctc       2211
Ala Val Lys Asn Phe Thr Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu           
635                 640                 645                 650           

cag gac ttt gac aaa agc aag cat gtc atc tat gct cca agc agc cac       2259
Gln Asp Phe Asp Lys Ser Lys His Val Ile Tyr Ala Pro Ser Ser His           
                655                 660                 665               

aac aag tat gca ggg gag tca ttc cca gga att tat gat gct ctg ttt       2307
Asn Lys Tyr Ala Gly Glu Ser Phe Pro Gly Ile Tyr Asp Ala Leu Phe           
            670                 675                 680                   

gat att gaa agc aaa gtg gac cct tcc aag gcc tgg gga gaa gtg aag       2355
Asp Ile Glu Ser Lys Val Asp Pro Ser Lys Ala Trp Gly Glu Val Lys           
        685                 690                 695                       

aga cag att tat gtt gca gcc ttc aca gtg cag gca gct gca gag act       2403
Arg Gln Ile Tyr Val Ala Ala Phe Thr Val Gln Ala Ala Ala Glu Thr           
    700                 705                 710                           

ttg agt gaa gta gcc taa gaggattctt tagagaatcc gtattgaatt              2451
Leu Ser Glu Val Ala                                                       
715                                                                       

tgtgtggtat gtcactcaga aagaatcgta atgggtatat tgataaattt taaaattggt     2511

atatttgaaa taaagttgaa tattatatat aaaaaaaaaa aaaaaaaaa                 2560


<210>  6
<211>  719
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Trp Asn Leu Leu His Glu Thr Asp Ser Ala Val Ala Thr Ala Arg 
1               5                   10                  15      


Arg Pro Arg Trp Leu Cys Ala Gly Ala Leu Val Leu Ala Gly Gly Phe 
            20                  25                  30          


Phe Leu Leu Gly Phe Leu Phe Gly Trp Phe Ile Lys Ser Ser Asn Glu 
        35                  40                  45              


Ala Thr Asn Ile Thr Pro Lys His Asn Met Lys Ala Phe Leu Asp Glu 
    50                  55                  60                  


Leu Lys Ala Glu Asn Ile Lys Lys Phe Leu Tyr Asn Phe Thr Gln Ile 
65                  70                  75                  80  


Pro His Leu Ala Gly Thr Glu Gln Asn Phe Gln Leu Ala Lys Gln Ile 
                85                  90                  95      


Gln Ser Gln Trp Lys Glu Phe Gly Leu Asp Ser Val Glu Leu Ala His 
            100                 105                 110         


Tyr Asp Val Leu Leu Ser Tyr Pro Asn Lys Thr His Pro Asn Tyr Ile 
        115                 120                 125             


Ser Ile Ile Asn Glu Asp Gly Asn Glu Ile Phe Asn Thr Ser Leu Phe 
    130                 135                 140                 


Glu Pro Pro Pro Pro Gly Tyr Glu Asn Val Ser Asp Ile Val Pro Pro 
145                 150                 155                 160 


Phe Ser Ala Phe Ser Pro Gln Gly Met Pro Glu Gly Asp Leu Val Tyr 
                165                 170                 175     


Val Asn Tyr Ala Arg Thr Glu Asp Phe Phe Lys Leu Glu Arg Asp Met 
            180                 185                 190         


Lys Ile Asn Cys Ser Gly Lys Ile Val Ile Ala Arg Tyr Gly Lys Val 
        195                 200                 205             


Phe Arg Gly Asn Lys Val Lys Asn Ala Gln Leu Ala Gly Ala Lys Gly 
    210                 215                 220                 


Val Ile Leu Tyr Ser Asp Pro Ala Asp Tyr Phe Ala Pro Gly Val Lys 
225                 230                 235                 240 


Ser Tyr Pro Asp Gly Trp Asn Leu Pro Gly Gly Gly Val Gln Arg Gly 
                245                 250                 255     


Asn Ile Leu Asn Leu Asn Gly Ala Gly Asp Pro Leu Thr Pro Gly Tyr 
            260                 265                 270         


Pro Ala Asn Glu Tyr Ala Tyr Arg Arg Gly Ile Ala Glu Ala Val Gly 
        275                 280                 285             


Leu Pro Ser Ile Pro Val His Pro Ile Gly Tyr Tyr Asp Ala Gln Lys 
    290                 295                 300                 


Leu Leu Glu Lys Met Gly Gly Ser Ala Pro Pro Asp Ser Ser Trp Arg 
305                 310                 315                 320 


Gly Ser Leu Lys Val Pro Tyr Asn Val Gly Pro Gly Phe Thr Gly Asn 
                325                 330                 335     


Phe Ser Thr Gln Lys Val Lys Met His Ile His Ser Thr Asn Glu Val 
            340                 345                 350         


Thr Arg Ile Tyr Asn Val Ile Gly Thr Leu Arg Gly Ala Val Glu Pro 
        355                 360                 365             


Asp Arg Tyr Val Ile Leu Gly Gly His Arg Asp Ser Trp Val Phe Gly 
    370                 375                 380                 


Gly Ile Asp Pro Gln Ser Gly Ala Ala Val Val His Glu Ile Val Arg 
385                 390                 395                 400 


Ser Phe Gly Thr Leu Lys Lys Glu Gly Trp Arg Pro Arg Arg Thr Ile 
                405                 410                 415     


Leu Phe Ala Ser Trp Asp Ala Glu Glu Phe Gly Leu Leu Gly Ser Thr 
            420                 425                 430         


Glu Trp Ala Glu Glu Asn Ser Arg Leu Leu Gln Glu Arg Gly Val Ala 
        435                 440                 445             


Tyr Ile Asn Ala Asp Ser Ser Ile Glu Gly Asn Tyr Thr Leu Arg Val 
    450                 455                 460                 


Asp Cys Thr Pro Leu Met Tyr Ser Leu Val His Asn Leu Thr Lys Glu 
465                 470                 475                 480 


Leu Lys Ser Pro Asp Glu Gly Phe Glu Gly Lys Ser Leu Tyr Glu Ser 
                485                 490                 495     


Trp Thr Lys Lys Ser Pro Ser Pro Glu Phe Ser Gly Met Pro Arg Ile 
            500                 505                 510         


Ser Lys Leu Gly Ser Gly Asn Asp Phe Glu Val Phe Phe Gln Arg Leu 
        515                 520                 525             


Gly Ile Ala Ser Gly Arg Ala Arg Tyr Thr Lys Asn Trp Glu Thr Asn 
    530                 535                 540                 


Lys Phe Ser Gly Tyr Pro Leu Tyr His Ser Val Tyr Glu Thr Tyr Glu 
545                 550                 555                 560 


Leu Val Glu Lys Phe Tyr Asp Pro Met Phe Lys Tyr His Leu Thr Val 
                565                 570                 575     


Ala Gln Val Arg Gly Gly Met Val Phe Glu Leu Ala Asn Ser Ile Val 
            580                 585                 590         


Leu Pro Phe Asp Cys Arg Asp Tyr Ala Val Val Leu Arg Lys Tyr Ala 
        595                 600                 605             


Asp Lys Ile Tyr Ser Ile Ser Met Lys His Pro Gln Glu Met Lys Thr 
    610                 615                 620                 


Tyr Ser Val Ser Phe Asp Ser Leu Phe Ser Ala Val Lys Asn Phe Thr 
625                 630                 635                 640 


Glu Ile Ala Ser Lys Phe Ser Glu Arg Leu Gln Asp Phe Asp Lys Ser 
                645                 650                 655     


Lys His Val Ile Tyr Ala Pro Ser Ser His Asn Lys Tyr Ala Gly Glu 
            660                 665                 670         


Ser Phe Pro Gly Ile Tyr Asp Ala Leu Phe Asp Ile Glu Ser Lys Val 
        675                 680                 685             


Asp Pro Ser Lys Ala Trp Gly Glu Val Lys Arg Gln Ile Tyr Val Ala 
    690                 695                 700                 


Ala Phe Thr Val Gln Ala Ala Ala Glu Thr Leu Ser Glu Val Ala 
705                 710                 715                 


<210>  7
<211>  1209
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (67)..(888)

<400>  7
acctctcaag cagccagcgc ctgcctgaat ctgttctgcc ccctccccac ccatttcacc       60

accacc atg aca ccg ggc acc cag tct cct ttc ttc ctg ctg ctg ctc         108
       Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu            
       1               5                   10                             

ctc aca gtg ctt aca gtt gtt acg ggt tct ggt cat gca agc tct acc        156
Leu Thr Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr           
15                  20                  25                  30            

cca ggt gga gaa aag gag act tcg gct acc cag aga agt tca gtg ccc        204
Pro Gly Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro           
                35                  40                  45                

agc tct act gag aag aat gct ttg tct act ggg gtc tct ttc ttt ttc        252
Ser Ser Thr Glu Lys Asn Ala Leu Ser Thr Gly Val Ser Phe Phe Phe           
            50                  55                  60                    

ctg tct ttt cac att tca aac ctc cag ttt aat tcc tct ctg gaa gat        300
Leu Ser Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp           
        65                  70                  75                        

ccc agc acc gac tac tac caa gag ctg cag aga gac att tct gaa atg        348
Pro Ser Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met           
    80                  85                  90                            

ttt ttg cag att tat aaa caa ggg ggt ttt ctg ggc ctc tcc aat att        396
Phe Leu Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile           
95                  100                 105                 110           

aag ttc agg cca gga tct gtg gtg gta caa ttg act ctg gcc ttc cga        444
Lys Phe Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg           
                115                 120                 125               

gaa ggt acc atc aat gtc cac gac gtg gag aca cag ttc aat cag tat        492
Glu Gly Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr           
            130                 135                 140                   

aaa acg gaa gca gcc tct cga tat aac ctg acg atc tca gac gtc agc        540
Lys Thr Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser           
        145                 150                 155                       

gtg agt gat gtg cca ttt cct ttc tct gcc cag tct ggg gct ggg gtg        588
Val Ser Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val           
    160                 165                 170                           

cca ggc tgg ggc atc gcg ctg ctg gtg ctg gtc tgt gtt ctg gtt gcg        636
Pro Gly Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala           
175                 180                 185                 190           

ctg gcc att gtc tat ctc att gcc ttg gct gtc tgt cag tgc cgc cga        684
Leu Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg           
                195                 200                 205               

aag aac tac ggg cag ctg gac atc ttt cca gcc cgg gat acc tac cat        732
Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His           
            210                 215                 220                   

cct atg agc gag tac ccc acc tac cac acc cat ggg cgc tat gtg ccc        780
Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro           
        225                 230                 235                       

cct agc agt acc gat cgt agc ccc tat gag aag gtt tct gca ggt aat        828
Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn           
    240                 245                 250                           

ggt ggc agc agc ctc tct tac aca aac cca gca gtg gca gcc act tct        876
Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser           
255                 260                 265                 270           

gcc aac ttg tag gggcacgtcg cccgctgagc tgagtggcca gccagtgcca            928
Ala Asn Leu                                                               
                                                                          

ttccactcca ctcaggttct tcagggccag agcccctgca ccctgtttgg gctggtgagc      988

tgggagttca ggtgggctgc tcacagcctc cttcagaggc cccaccaatt tctcggacac     1048

ttctcagtgt gtggaagctc atgtgggccc ctgagggctc atgcctggga agtgttgtgg     1108

tgggggctcc caggaggact ggcccagaga gccctgagat agcggggatc ctgaactgga     1168

ctgaataaaa cgtggtctcc cactgcgcca aaaaaaaaaa a                         1209


<210>  8
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr 
1               5                   10                  15      


Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 
            20                  25                  30          


Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 
        35                  40                  45              


Thr Glu Lys Asn Ala Leu Ser Thr Gly Val Ser Phe Phe Phe Leu Ser 
    50                  55                  60                  


Phe His Ile Ser Asn Leu Gln Phe Asn Ser Ser Leu Glu Asp Pro Ser 
65                  70                  75                  80  


Thr Asp Tyr Tyr Gln Glu Leu Gln Arg Asp Ile Ser Glu Met Phe Leu 
                85                  90                  95      


Gln Ile Tyr Lys Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe 
            100                 105                 110         


Arg Pro Gly Ser Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly 
        115                 120                 125             


Thr Ile Asn Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr 
    130                 135                 140                 


Glu Ala Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser 
145                 150                 155                 160 


Asp Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly 
                165                 170                 175     


Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu Ala 
            180                 185                 190         


Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg Lys Asn 
        195                 200                 205             


Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr His Pro Met 
    210                 215                 220                 


Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr Val Pro Pro Ser 
225                 230                 235                 240 


Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser Ala Gly Asn Gly Gly 
                245                 250                 255     


Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val Ala Ala Thr Ser Ala Asn 
            260                 265                 270         


Leu 
    


<210>  9
<211>  1764
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (107)..(1513)

<400>  9
gcaggtgccc cgaaaagggg gcggggtcag gggtgccctg aactccgaat gcgaagttct       60

gtcttgtcat agccaagcac gctgcttctt ggattgacct ggcagg atg gcg cca         115
                                                   Met Ala Pro            
                                                   1                      

cca cca gct aga gta cat cta ggt gcg ttc ctg gca gtg act ccg aat        163
Pro Pro Ala Arg Val His Leu Gly Ala Phe Leu Ala Val Thr Pro Asn           
    5                   10                  15                            

ccc ggg agc gca gcg agt ggg aca gag gca gcc gcg gcc aca ccc agc        211
Pro Gly Ser Ala Ala Ser Gly Thr Glu Ala Ala Ala Ala Thr Pro Ser           
20                  25                  30                  35            

aaa gtg tgg ggc tct tcc gcg ggg agg att gaa cca cga ggc ggg ggc        259
Lys Val Trp Gly Ser Ser Ala Gly Arg Ile Glu Pro Arg Gly Gly Gly           
                40                  45                  50                

cga gga gcg ctc cct acc tcc atg gga cag cac gga ccc agt gcc cgg        307
Arg Gly Ala Leu Pro Thr Ser Met Gly Gln His Gly Pro Ser Ala Arg           
            55                  60                  65                    

gcc cgg gca ggg cgc gcc cca gga ccc agg ccg gcg cgg gaa gcc agc        355
Ala Arg Ala Gly Arg Ala Pro Gly Pro Arg Pro Ala Arg Glu Ala Ser           
        70                  75                  80                        

cct cgg ctc cgg gtc cac aag acc ttc aag ttt gtc gtc gtc ggg gtc        403
Pro Arg Leu Arg Val His Lys Thr Phe Lys Phe Val Val Val Gly Val           
    85                  90                  95                            

ctg ctg cag gtc gta cct agc tca gct gca acc atc aaa ctt cat gat        451
Leu Leu Gln Val Val Pro Ser Ser Ala Ala Thr Ile Lys Leu His Asp           
100                 105                 110                 115           

caa tca att ggc aca cag caa tgg gaa cat agc cct ttg gga gag ttg        499
Gln Ser Ile Gly Thr Gln Gln Trp Glu His Ser Pro Leu Gly Glu Leu           
                120                 125                 130               

tgt cca cca gga tct cat aga tca gaa cat cct gga gcc tgt aac cgg        547
Cys Pro Pro Gly Ser His Arg Ser Glu His Pro Gly Ala Cys Asn Arg           
            135                 140                 145                   

tgc aca gag ggt gtg ggt tac acc aat gct tcc aac aat ttg ttt gct        595
Cys Thr Glu Gly Val Gly Tyr Thr Asn Ala Ser Asn Asn Leu Phe Ala           
        150                 155                 160                       

tgc ctc cca tgt aca gct tgt aaa tca gat gaa gaa gag aga agt ccc        643
Cys Leu Pro Cys Thr Ala Cys Lys Ser Asp Glu Glu Glu Arg Ser Pro           
    165                 170                 175                           

tgc acc acg acc agg aac aca gca tgt cag tgc aaa cca gga act ttc        691
Cys Thr Thr Thr Arg Asn Thr Ala Cys Gln Cys Lys Pro Gly Thr Phe           
180                 185                 190                 195           

cgg aat gac aat tct gct gag atg tgc cgg aag tgc agc aga ggg tgc        739
Arg Asn Asp Asn Ser Ala Glu Met Cys Arg Lys Cys Ser Arg Gly Cys           
                200                 205                 210               

ccc aga ggg atg gtc aag gtc aag gat tgt acg ccc tgg agt gac atc        787
Pro Arg Gly Met Val Lys Val Lys Asp Cys Thr Pro Trp Ser Asp Ile           
            215                 220                 225                   

gag tgt gtc cac aaa gaa tca ggc aat gga cat aat ata tgg gtg att        835
Glu Cys Val His Lys Glu Ser Gly Asn Gly His Asn Ile Trp Val Ile           
        230                 235                 240                       

ttg gtt gtg act ttg gtt gtt ccg ttg ctg ttg gtg gct gtg ctg att        883
Leu Val Val Thr Leu Val Val Pro Leu Leu Leu Val Ala Val Leu Ile           
    245                 250                 255                           

gtc tgt tgt tgc atc ggc tca ggt tgt gga ggg gac ccc aag tgc atg        931
Val Cys Cys Cys Ile Gly Ser Gly Cys Gly Gly Asp Pro Lys Cys Met           
260                 265                 270                 275           

gac agg gtg tgt ttc tgg cgc ttg ggt ctc cta cga ggg cct ggg gct        979
Asp Arg Val Cys Phe Trp Arg Leu Gly Leu Leu Arg Gly Pro Gly Ala           
                280                 285                 290               

gag gac aat gct cac aac gag att ctg agc aac gca gac tcg ctg tcc       1027
Glu Asp Asn Ala His Asn Glu Ile Leu Ser Asn Ala Asp Ser Leu Ser           
            295                 300                 305                   

act ttc gtc tct gag cag caa atg gaa agc cag gag ccg gca gat ttg       1075
Thr Phe Val Ser Glu Gln Gln Met Glu Ser Gln Glu Pro Ala Asp Leu           
        310                 315                 320                       

aca ggt gtc act gta cag tcc cca ggg gag gca cag tgt ctg ctg gga       1123
Thr Gly Val Thr Val Gln Ser Pro Gly Glu Ala Gln Cys Leu Leu Gly           
    325                 330                 335                           

ccg gca gaa gct gaa ggg tct cag agg agg agg ctg ctg gtt cca gca       1171
Pro Ala Glu Ala Glu Gly Ser Gln Arg Arg Arg Leu Leu Val Pro Ala           
340                 345                 350                 355           

aat ggt gct gac ccc act gag act ctg atg ctg ttc ttt gac aag ttt       1219
Asn Gly Ala Asp Pro Thr Glu Thr Leu Met Leu Phe Phe Asp Lys Phe           
                360                 365                 370               

gca aac atc gtg ccc ttt gac tcc tgg gac cag ctc atg agg cag ctg       1267
Ala Asn Ile Val Pro Phe Asp Ser Trp Asp Gln Leu Met Arg Gln Leu           
            375                 380                 385                   

gac ctc acg aaa aat gag atc gat gtg gtc aga gct ggt aca gca ggc       1315
Asp Leu Thr Lys Asn Glu Ile Asp Val Val Arg Ala Gly Thr Ala Gly           
        390                 395                 400                       

cca ggg gat gcc ttg tat gca atg ctg atg aaa tgg gtc aac aaa act       1363
Pro Gly Asp Ala Leu Tyr Ala Met Leu Met Lys Trp Val Asn Lys Thr           
    405                 410                 415                           

gga cgg aac gcc tcg atc cac acc ctg ctg gat gcc ttg gag agg atg       1411
Gly Arg Asn Ala Ser Ile His Thr Leu Leu Asp Ala Leu Glu Arg Met           
420                 425                 430                 435           

gaa gag aga cat gca aga gag aag att cag gac ctc ttg gtg gac tct       1459
Glu Glu Arg His Ala Arg Glu Lys Ile Gln Asp Leu Leu Val Asp Ser           
                440                 445                 450               

gga aag ttc atc tac tta gaa gat ggc aca ggc tct gcc gtg tcc ttg       1507
Gly Lys Phe Ile Tyr Leu Glu Asp Gly Thr Gly Ser Ala Val Ser Leu           
            455                 460                 465                   

gag tga aagactcttt ttaccagagg tttcctctta ggtgttagga gttaatacat        1563
Glu                                                                       
                                                                          

attaggtttt tttttttttt aacatgtata caaagtaaat tcttagccag gtgtagtggc     1623

tcatgcctgt aatcccagca ctttgggagg ctgaggcggg tggatcactt gaggtcagaa     1683

gttcaagacc agcctgacca acatcgtgaa atgccgtctt tacaaaaaaa tacaaaaatt     1743

aactggaaaa aaaaaaaaaa a                                               1764


<210>  10
<211>  468
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Pro Pro Pro Ala Arg Val His Leu Gly Ala Phe Leu Ala Val 
1               5                   10                  15      


Thr Pro Asn Pro Gly Ser Ala Ala Ser Gly Thr Glu Ala Ala Ala Ala 
            20                  25                  30          


Thr Pro Ser Lys Val Trp Gly Ser Ser Ala Gly Arg Ile Glu Pro Arg 
        35                  40                  45              


Gly Gly Gly Arg Gly Ala Leu Pro Thr Ser Met Gly Gln His Gly Pro 
    50                  55                  60                  


Ser Ala Arg Ala Arg Ala Gly Arg Ala Pro Gly Pro Arg Pro Ala Arg 
65                  70                  75                  80  


Glu Ala Ser Pro Arg Leu Arg Val His Lys Thr Phe Lys Phe Val Val 
                85                  90                  95      


Val Gly Val Leu Leu Gln Val Val Pro Ser Ser Ala Ala Thr Ile Lys 
            100                 105                 110         


Leu His Asp Gln Ser Ile Gly Thr Gln Gln Trp Glu His Ser Pro Leu 
        115                 120                 125             


Gly Glu Leu Cys Pro Pro Gly Ser His Arg Ser Glu His Pro Gly Ala 
    130                 135                 140                 


Cys Asn Arg Cys Thr Glu Gly Val Gly Tyr Thr Asn Ala Ser Asn Asn 
145                 150                 155                 160 


Leu Phe Ala Cys Leu Pro Cys Thr Ala Cys Lys Ser Asp Glu Glu Glu 
                165                 170                 175     


Arg Ser Pro Cys Thr Thr Thr Arg Asn Thr Ala Cys Gln Cys Lys Pro 
            180                 185                 190         


Gly Thr Phe Arg Asn Asp Asn Ser Ala Glu Met Cys Arg Lys Cys Ser 
        195                 200                 205             


Arg Gly Cys Pro Arg Gly Met Val Lys Val Lys Asp Cys Thr Pro Trp 
    210                 215                 220                 


Ser Asp Ile Glu Cys Val His Lys Glu Ser Gly Asn Gly His Asn Ile 
225                 230                 235                 240 


Trp Val Ile Leu Val Val Thr Leu Val Val Pro Leu Leu Leu Val Ala 
                245                 250                 255     


Val Leu Ile Val Cys Cys Cys Ile Gly Ser Gly Cys Gly Gly Asp Pro 
            260                 265                 270         


Lys Cys Met Asp Arg Val Cys Phe Trp Arg Leu Gly Leu Leu Arg Gly 
        275                 280                 285             


Pro Gly Ala Glu Asp Asn Ala His Asn Glu Ile Leu Ser Asn Ala Asp 
    290                 295                 300                 


Ser Leu Ser Thr Phe Val Ser Glu Gln Gln Met Glu Ser Gln Glu Pro 
305                 310                 315                 320 


Ala Asp Leu Thr Gly Val Thr Val Gln Ser Pro Gly Glu Ala Gln Cys 
                325                 330                 335     


Leu Leu Gly Pro Ala Glu Ala Glu Gly Ser Gln Arg Arg Arg Leu Leu 
            340                 345                 350         


Val Pro Ala Asn Gly Ala Asp Pro Thr Glu Thr Leu Met Leu Phe Phe 
        355                 360                 365             


Asp Lys Phe Ala Asn Ile Val Pro Phe Asp Ser Trp Asp Gln Leu Met 
    370                 375                 380                 


Arg Gln Leu Asp Leu Thr Lys Asn Glu Ile Asp Val Val Arg Ala Gly 
385                 390                 395                 400 


Thr Ala Gly Pro Gly Asp Ala Leu Tyr Ala Met Leu Met Lys Trp Val 
                405                 410                 415     


Asn Lys Thr Gly Arg Asn Ala Ser Ile His Thr Leu Leu Asp Ala Leu 
            420                 425                 430         


Glu Arg Met Glu Glu Arg His Ala Arg Glu Lys Ile Gln Asp Leu Leu 
        435                 440                 445             


Val Asp Ser Gly Lys Phe Ile Tyr Leu Glu Asp Gly Thr Gly Ser Ala 
    450                 455                 460                 


Val Ser Leu Glu 
465             


<210>  11
<211>  4154
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (294)..(1616)

<400>  11
acttggacgc gcttgcggag gattgcgttg acgagactct tatttattgt caccaacctg       60

tggtggaatt tgcagttgca cattggatct gattcgcccc gccccgaatg acgcctgccc      120

ggaggcagtg aaagtacagc cgcgccgccc caagtcagcc tggacacata aatcagcacg      180

cggccggaga accccgcaat ctctgcgccc acaaaataca ccgacgatgc ccgatctact      240

ttaagggctg aaacccacgg gcctgagaga ctataagagc gttccctacc gcc atg         296
                                                           Met            
                                                           1              

gaa caa cgg gga cag aac gcc ccg gcc gct tcg ggg gcc cgg aaa agg        344
Glu Gln Arg Gly Gln Asn Ala Pro Ala Ala Ser Gly Ala Arg Lys Arg           
            5                   10                  15                    

cac ggc cca gga ccc agg gag gcg cgg gga gcc agg cct ggg ccc cgg        392
His Gly Pro Gly Pro Arg Glu Ala Arg Gly Ala Arg Pro Gly Pro Arg           
        20                  25                  30                        

gtc ccc aag acc ctt gtg ctc gtt gtc gcc gcg gtc ctg ctg ttg gtc        440
Val Pro Lys Thr Leu Val Leu Val Val Ala Ala Val Leu Leu Leu Val           
    35                  40                  45                            

tca gct gag tct gct ctg atc acc caa caa gac cta gct ccc cag cag        488
Ser Ala Glu Ser Ala Leu Ile Thr Gln Gln Asp Leu Ala Pro Gln Gln           
50                  55                  60                  65            

aga gcg gcc cca caa caa aag agg tcc agc ccc tca gag gga ttg tgt        536
Arg Ala Ala Pro Gln Gln Lys Arg Ser Ser Pro Ser Glu Gly Leu Cys           
                70                  75                  80                

cca cct gga cac cat atc tca gaa gac ggt aga gat tgc atc tcc tgc        584
Pro Pro Gly His His Ile Ser Glu Asp Gly Arg Asp Cys Ile Ser Cys           
            85                  90                  95                    

aaa tat gga cag gac tat agc act cac tgg aat gac ctc ctt ttc tgc        632
Lys Tyr Gly Gln Asp Tyr Ser Thr His Trp Asn Asp Leu Leu Phe Cys           
        100                 105                 110                       

ttg cgc tgc acc agg tgt gat tca ggt gaa gtg gag cta agt ccc tgc        680
Leu Arg Cys Thr Arg Cys Asp Ser Gly Glu Val Glu Leu Ser Pro Cys           
    115                 120                 125                           

acc acg acc aga aac aca gtg tgt cag tgc gaa gaa ggc acc ttc cgg        728
Thr Thr Thr Arg Asn Thr Val Cys Gln Cys Glu Glu Gly Thr Phe Arg           
130                 135                 140                 145           

gaa gaa gat tct cct gag atg tgc cgg aag tgc cgc aca ggg tgt ccc        776
Glu Glu Asp Ser Pro Glu Met Cys Arg Lys Cys Arg Thr Gly Cys Pro           
                150                 155                 160               

aga ggg atg gtc aag gtc ggt gat tgt aca ccc tgg agt gac atc gaa        824
Arg Gly Met Val Lys Val Gly Asp Cys Thr Pro Trp Ser Asp Ile Glu           
            165                 170                 175                   

tgt gtc cac aaa gaa tca ggt aca aag cac agt ggg gaa gtc cca gct        872
Cys Val His Lys Glu Ser Gly Thr Lys His Ser Gly Glu Val Pro Ala           
        180                 185                 190                       

gtg gag gag acg gtg acc tcc agc cca ggg act cct gcc tct ccc tgt        920
Val Glu Glu Thr Val Thr Ser Ser Pro Gly Thr Pro Ala Ser Pro Cys           
    195                 200                 205                           

tct ctc tca ggc atc atc ata gga gtc aca gtt gca gcc gta gtc ttg        968
Ser Leu Ser Gly Ile Ile Ile Gly Val Thr Val Ala Ala Val Val Leu           
210                 215                 220                 225           

att gtg gct gtg ttt gtt tgc aag tct tta ctg tgg aag aaa gtc ctt       1016
Ile Val Ala Val Phe Val Cys Lys Ser Leu Leu Trp Lys Lys Val Leu           
                230                 235                 240               

cct tac ctg aaa ggc atc tgc tca ggt ggt ggt ggg gac cct gag cgt       1064
Pro Tyr Leu Lys Gly Ile Cys Ser Gly Gly Gly Gly Asp Pro Glu Arg           
            245                 250                 255                   

gtg gac aga agc tca caa cga cct ggg gct gag gac aat gtc ctc aat       1112
Val Asp Arg Ser Ser Gln Arg Pro Gly Ala Glu Asp Asn Val Leu Asn           
        260                 265                 270                       

gag atc gtg agt atc ttg cag ccc acc cag gtc cct gag cag gaa atg       1160
Glu Ile Val Ser Ile Leu Gln Pro Thr Gln Val Pro Glu Gln Glu Met           
    275                 280                 285                           

gaa gtc cag gag cca gca gag cca aca ggt gtc aac atg ttg tcc ccc       1208
Glu Val Gln Glu Pro Ala Glu Pro Thr Gly Val Asn Met Leu Ser Pro           
290                 295                 300                 305           

ggg gag tca gag cat ctg ctg gaa ccg gca gaa gct gaa agg tct cag       1256
Gly Glu Ser Glu His Leu Leu Glu Pro Ala Glu Ala Glu Arg Ser Gln           
                310                 315                 320               

agg agg agg ctg ctg gtt cca gca aat gaa ggt gat ccc act gag act       1304
Arg Arg Arg Leu Leu Val Pro Ala Asn Glu Gly Asp Pro Thr Glu Thr           
            325                 330                 335                   

ctg aga cag tgc ttc gat gac ttt gca gac ttg gtg ccc ttt gac tcc       1352
Leu Arg Gln Cys Phe Asp Asp Phe Ala Asp Leu Val Pro Phe Asp Ser           
        340                 345                 350                       

tgg gag ccg ctc atg agg aag ttg ggc ctc atg gac aat gag ata aag       1400
Trp Glu Pro Leu Met Arg Lys Leu Gly Leu Met Asp Asn Glu Ile Lys           
    355                 360                 365                           

gtg gct aaa gct gag gca gcg ggc cac agg gac acc ttg tac acg atg       1448
Val Ala Lys Ala Glu Ala Ala Gly His Arg Asp Thr Leu Tyr Thr Met           
370                 375                 380                 385           

ctg ata aag tgg gtc aac aaa acc ggg cga gat gcc tct gtc cac acc       1496
Leu Ile Lys Trp Val Asn Lys Thr Gly Arg Asp Ala Ser Val His Thr           
                390                 395                 400               

ctg ctg gat gcc ttg gag acg ctg gga gag aga ctt gcc aag cag aag       1544
Leu Leu Asp Ala Leu Glu Thr Leu Gly Glu Arg Leu Ala Lys Gln Lys           
            405                 410                 415                   

att gag gac cac ttg ttg agc tct gga aag ttc atg tat cta gaa ggt       1592
Ile Glu Asp His Leu Leu Ser Ser Gly Lys Phe Met Tyr Leu Glu Gly           
        420                 425                 430                       

aat gca gac tct gcc atg tcc taa gtgtgattct cttcaggaag tcagaccttc      1646
Asn Ala Asp Ser Ala Met Ser                                               
    435                 440                                               

cctggtttac cttttttctg gaaaaagccc aactggactc cagtcagtag gaaagtgcca     1706

caattgtcac atgaccggta ctggaagaaa ctctcccatc caacatcacc cagtggatgg     1766

aacatcctgt aacttttcac tgcacttggc attattttta taagctgaat gtgataataa     1826

ggacactatg gaaatgtctg gatcattccg tttgtgcgta ctttgagatt tggtttggga     1886

tgtcattgtt ttcacagcac ttttttatcc taatgtaaat gctttattta tttatttggg     1946

ctacattgta agatccatct acacagtcgt tgtccgactt cacttgatac tatatgatat     2006

gaaccttttt tgggtggggg gtgcggggca gttcactctg tctcccaggc tggagtgcaa     2066

tggtgcaatc ttggctcact atagccttga cctctcaggc tcaagcgatt ctcccacctc     2126

agccatccaa atagctggga ccacaggtgt gcaccaccac gcccggctaa ttttttgtat     2186

tttgtctaga tataggggct ctctatgttg ctcagggtgg tctcgaattc ctggactcaa     2246

gcagtctgcc cacctcagac tcccaaagcg gtggaattag aggcgtgagc ccccatgctt     2306

ggccttacct ttctactttt ataattctgt atgttattat tttatgaaca tgaagaaact     2366

ttagtaaatg tacttgttta catagttatg tgaatagatt agataaacat aaaaggagga     2426

gacatacaat gggggaagaa gaagaagtcc cctgtaagat gtcactgtct gggttccagc     2486

cctccctcag atgtactttg gcttcaatga ttggcaactt ctacaggggc cagtcttttg     2546

aactggacaa ccttacaagt atatgagtat tatttatagg tagttgttta catatgagtc     2606

gggaccaaag agaactggat ccacgtgaag tcctgtgtgt ggctggtccc tacctgggca     2666

gtctcatttg cacccatagc ccccatctat ggacaggctg ggacagaggc agatgggtta     2726

gatcacacat aacaataggg tctatgtcat atcccaagtg aacttgagcc ctgtttgggc     2786

tcaggagata gaagacaaaa tctgtctccc acgtctgcca tggcatcaag ggggaagagt     2846

agatggtgct tgagaatggt gtgaaatggt tgccatctca ggagtagatg gcccggctca     2906

cttctggtta tctgtcaccc tgagcccatg agctgccttt tagggtacag attgcctact     2966

tgaggacctt ggccgctctg taagcatctg actcatctca gaaatgtcaa ttcttaaaca     3026

ctgtggcaac aggacctaga atggctgacg cattaaggtt ttcttcttgt gtcctgttct     3086

attattgttt taagacctca gtaaccattt cagcctcttt ccagcaaacc cttctccata     3146

gtatttcagt catggaagga tcatttatgc aggtagtcat tccaggagtt tttggtcttt     3206

tctgtctcaa ggcattgtgt gttttgttcc gggactggtt tgggtgggac aaagttagaa     3266

ttgcctgaag atcacacatt cagactgttg tgtctgtgga gttttaggag tggggggtga     3326

cctttctggt ctttgcactt ccatcctctc ccacttccat ctggcatccc acgcgttgtc     3386

ccctgcactt ctggaaggca cagggtgctg ctgcctcctg gtctttgcct ttgctgggcc     3446

ttctgtgcag gacgctcagc ctcagggctc agaaggtgcc agtccggtcc caggtccctt     3506

gtcccttcca cagaggcctt cctagaagat gcatctagag tgtcagcctt atcagtgttt     3566

aagatttttc ttttattttt aatttttttg agacagaatc tcactctctc gcccaggctg     3626

gagtgcaacg gtacgatctt ggctcagtgc aacctccgcc tcctgggttc aagcgattct     3686

cgtgcctcag cctccggagt agctgggatt gcaggcaccc gccaccacgc ctggctaatt     3746

tttgtatttt tagtagagac ggggtttcac catgttggtc aggctggtct cgaactcctg     3806

acctcaggtg atccaccttg gcctccgaaa gtgctgggat tacaggcgtg agccaccagc     3866

caggccaagc tattctttta aagtaagctt cctgacgaca tgaaataatt gggggttttg     3926

ttgtttagtt acattaggct ttgctatatc cccaggccaa atagcatgtg acacaggaca     3986

gccatagtat agtgtgtcac tcgtggttgg tgtcctttca tgcttctgcc ctgtcaaagg     4046

tccctatttg aaatgtgtta taatacaaac aaggaagcac attgtgtaca aaatacttat     4106

gtatttatga atccatgacc aaattaaata tgaaacctta tataaaaa                  4154


<210>  12
<211>  440
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Glu Gln Arg Gly Gln Asn Ala Pro Ala Ala Ser Gly Ala Arg Lys 
1               5                   10                  15      


Arg His Gly Pro Gly Pro Arg Glu Ala Arg Gly Ala Arg Pro Gly Pro 
            20                  25                  30          


Arg Val Pro Lys Thr Leu Val Leu Val Val Ala Ala Val Leu Leu Leu 
        35                  40                  45              


Val Ser Ala Glu Ser Ala Leu Ile Thr Gln Gln Asp Leu Ala Pro Gln 
    50                  55                  60                  


Gln Arg Ala Ala Pro Gln Gln Lys Arg Ser Ser Pro Ser Glu Gly Leu 
65                  70                  75                  80  


Cys Pro Pro Gly His His Ile Ser Glu Asp Gly Arg Asp Cys Ile Ser 
                85                  90                  95      


Cys Lys Tyr Gly Gln Asp Tyr Ser Thr His Trp Asn Asp Leu Leu Phe 
            100                 105                 110         


Cys Leu Arg Cys Thr Arg Cys Asp Ser Gly Glu Val Glu Leu Ser Pro 
        115                 120                 125             


Cys Thr Thr Thr Arg Asn Thr Val Cys Gln Cys Glu Glu Gly Thr Phe 
    130                 135                 140                 


Arg Glu Glu Asp Ser Pro Glu Met Cys Arg Lys Cys Arg Thr Gly Cys 
145                 150                 155                 160 


Pro Arg Gly Met Val Lys Val Gly Asp Cys Thr Pro Trp Ser Asp Ile 
                165                 170                 175     


Glu Cys Val His Lys Glu Ser Gly Thr Lys His Ser Gly Glu Val Pro 
            180                 185                 190         


Ala Val Glu Glu Thr Val Thr Ser Ser Pro Gly Thr Pro Ala Ser Pro 
        195                 200                 205             


Cys Ser Leu Ser Gly Ile Ile Ile Gly Val Thr Val Ala Ala Val Val 
    210                 215                 220                 


Leu Ile Val Ala Val Phe Val Cys Lys Ser Leu Leu Trp Lys Lys Val 
225                 230                 235                 240 


Leu Pro Tyr Leu Lys Gly Ile Cys Ser Gly Gly Gly Gly Asp Pro Glu 
                245                 250                 255     


Arg Val Asp Arg Ser Ser Gln Arg Pro Gly Ala Glu Asp Asn Val Leu 
            260                 265                 270         


Asn Glu Ile Val Ser Ile Leu Gln Pro Thr Gln Val Pro Glu Gln Glu 
        275                 280                 285             


Met Glu Val Gln Glu Pro Ala Glu Pro Thr Gly Val Asn Met Leu Ser 
    290                 295                 300                 


Pro Gly Glu Ser Glu His Leu Leu Glu Pro Ala Glu Ala Glu Arg Ser 
305                 310                 315                 320 


Gln Arg Arg Arg Leu Leu Val Pro Ala Asn Glu Gly Asp Pro Thr Glu 
                325                 330                 335     


Thr Leu Arg Gln Cys Phe Asp Asp Phe Ala Asp Leu Val Pro Phe Asp 
            340                 345                 350         


Ser Trp Glu Pro Leu Met Arg Lys Leu Gly Leu Met Asp Asn Glu Ile 
        355                 360                 365             


Lys Val Ala Lys Ala Glu Ala Ala Gly His Arg Asp Thr Leu Tyr Thr 
    370                 375                 380                 


Met Leu Ile Lys Trp Val Asn Lys Thr Gly Arg Asp Ala Ser Val His 
385                 390                 395                 400 


Thr Leu Leu Asp Ala Leu Glu Thr Leu Gly Glu Arg Leu Ala Lys Gln 
                405                 410                 415     


Lys Ile Glu Asp His Leu Leu Ser Ser Gly Lys Phe Met Tyr Leu Glu 
            420                 425                 430         


Gly Asn Ala Asp Ser Ala Met Ser 
        435                 440 


<210>  13
<211>  8588
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (481)..(7953)

<400>  13
gagtagctcc agcggccacg ctgaggcgag ggtgacacac catgctcacg gcccctggag       60

accgtcgtgc tggcgagccg tgctccgtag ctccccggtc cgcctcggca gcggtcagag      120

tcgcctacag gagttgagcc gcccgcgcca gaaggttttg gcgaagctct tggagaggcg      180

tcgagcacag tagggcggcg ggggtgcgtt gagcgctcgg gggtcaggca gtcggccggg      240

atcgccgctg gggagcgttt ccgaggcgag gaggaggagg aggagatgct gctcctcttc      300

tccccctccc caggctcctt ctacagctcc ttcagcccac gcccgcagcc gcttgtggga      360

gaagtggtgg tggctctcgg cgcccgcggc ggctgccggc ggcccgcccc gacgccgcgt      420

ccctgcagcc ctcgcccggc gctccagtag caggacccgg tctcgggacc agccggtaat      480

atg cac gtg tca cta gct gag gcc ctg gag gtt cgg ggt gga cca ctt        528
Met His Val Ser Leu Ala Glu Ala Leu Glu Val Arg Gly Gly Pro Leu           
1               5                   10                  15                

cag gag gaa gaa ata tgg gct gta tta aat caa agt gct gaa agt ctc        576
Gln Glu Glu Glu Ile Trp Ala Val Leu Asn Gln Ser Ala Glu Ser Leu           
            20                  25                  30                    

caa gaa tta ttc aga aaa gta agc cta gct gat cct gct gcc ctt ggc        624
Gln Glu Leu Phe Arg Lys Val Ser Leu Ala Asp Pro Ala Ala Leu Gly           
        35                  40                  45                        

ttc atc att tct cca tgg tct ctg ctg ttg ctg cca tct ggt agt gtg        672
Phe Ile Ile Ser Pro Trp Ser Leu Leu Leu Leu Pro Ser Gly Ser Val           
    50                  55                  60                            

tca ttt aca gat gaa aat att tcc aat cag gat ctt cga gca ttc act        720
Ser Phe Thr Asp Glu Asn Ile Ser Asn Gln Asp Leu Arg Ala Phe Thr           
65                  70                  75                  80            

gca cca gag gtt ctt caa aat cag tca cta act tct ctc tca gat gtt        768
Ala Pro Glu Val Leu Gln Asn Gln Ser Leu Thr Ser Leu Ser Asp Val           
                85                  90                  95                

gaa aag atc cac att tat tct ctt gga atg aca ctg tat tgg ggg gct        816
Glu Lys Ile His Ile Tyr Ser Leu Gly Met Thr Leu Tyr Trp Gly Ala           
            100                 105                 110                   

gat tat gaa gtg cct cag agc caa cct att aag ctt gga gat cat ctc        864
Asp Tyr Glu Val Pro Gln Ser Gln Pro Ile Lys Leu Gly Asp His Leu           
        115                 120                 125                       

aac agc ata ctg ctt gga atg tgt gag gat gtt att tac gct cga gtt        912
Asn Ser Ile Leu Leu Gly Met Cys Glu Asp Val Ile Tyr Ala Arg Val           
    130                 135                 140                           

tct gtt cgg act gtg ctg gat gct tgc agt gcc cac att agg aat agc        960
Ser Val Arg Thr Val Leu Asp Ala Cys Ser Ala His Ile Arg Asn Ser           
145                 150                 155                 160           

aat tgt gca ccc tca ttt tcc tac gtg aaa cac ttg gta aaa ctg gtt       1008
Asn Cys Ala Pro Ser Phe Ser Tyr Val Lys His Leu Val Lys Leu Val           
                165                 170                 175               

ctg gga aat ctt tct ggg aca gat cag ctt tcc tgt aac agt gaa caa       1056
Leu Gly Asn Leu Ser Gly Thr Asp Gln Leu Ser Cys Asn Ser Glu Gln           
            180                 185                 190                   

aag cct gat cga agc cag gct att cga gat cga ttg cga gga aaa gga       1104
Lys Pro Asp Arg Ser Gln Ala Ile Arg Asp Arg Leu Arg Gly Lys Gly           
        195                 200                 205                       

tta cca aca gga aga agc tct act tct gat gta cta gac ata caa aag       1152
Leu Pro Thr Gly Arg Ser Ser Thr Ser Asp Val Leu Asp Ile Gln Lys           
    210                 215                 220                           

cct cca ctc tct cat cag acc ttt ctt aac aaa ggg ctt agt aaa tct       1200
Pro Pro Leu Ser His Gln Thr Phe Leu Asn Lys Gly Leu Ser Lys Ser           
225                 230                 235                 240           

atg gga ttt ctg tcc atc aaa gat aca caa gat gag aat tat ttc aag       1248
Met Gly Phe Leu Ser Ile Lys Asp Thr Gln Asp Glu Asn Tyr Phe Lys           
                245                 250                 255               

gac att tta tca gat aat tct gga cgt gaa gat tct gaa aat aca ttc       1296
Asp Ile Leu Ser Asp Asn Ser Gly Arg Glu Asp Ser Glu Asn Thr Phe           
            260                 265                 270                   

tcc cct tac cag ttc aaa act agt ggc cca gaa aaa aaa ccc atc cct       1344
Ser Pro Tyr Gln Phe Lys Thr Ser Gly Pro Glu Lys Lys Pro Ile Pro           
        275                 280                 285                       

ggc att gat gtg ctt tct aag aag aag atc tgg gct tca tcc atg gac       1392
Gly Ile Asp Val Leu Ser Lys Lys Lys Ile Trp Ala Ser Ser Met Asp           
    290                 295                 300                           

ttg ctt tgt aca gct gac aga gac ttc tct tca gga gag act gcc aca       1440
Leu Leu Cys Thr Ala Asp Arg Asp Phe Ser Ser Gly Glu Thr Ala Thr           
305                 310                 315                 320           

tat cgt cgt tgt cac cct gag gca gta aca gtg cgg act tca act act       1488
Tyr Arg Arg Cys His Pro Glu Ala Val Thr Val Arg Thr Ser Thr Thr           
                325                 330                 335               

cct aga aaa aag gag gca aga tac tca gat gga agt ata gcc ttg gat       1536
Pro Arg Lys Lys Glu Ala Arg Tyr Ser Asp Gly Ser Ile Ala Leu Asp           
            340                 345                 350                   

atc ttt ggc cct cag aaa atg gat cca ata tat cac act cga gaa ttg       1584
Ile Phe Gly Pro Gln Lys Met Asp Pro Ile Tyr His Thr Arg Glu Leu           
        355                 360                 365                       

ccc acc tcc tca gca ata tca agt gct ttg gac cga atc cga gag aga       1632
Pro Thr Ser Ser Ala Ile Ser Ser Ala Leu Asp Arg Ile Arg Glu Arg           
    370                 375                 380                           

caa aag aaa ctt cag gtt ctg agg gaa gcc atg aat gta gaa gaa cca       1680
Gln Lys Lys Leu Gln Val Leu Arg Glu Ala Met Asn Val Glu Glu Pro           
385                 390                 395                 400           

gtt cga aga tac aaa act tat cat ggt gat gtc ttt agt acc tcc agt       1728
Val Arg Arg Tyr Lys Thr Tyr His Gly Asp Val Phe Ser Thr Ser Ser           
                405                 410                 415               

gaa agt cca tct att att tcc tct gaa tca gat ttc aga caa gtg aga       1776
Glu Ser Pro Ser Ile Ile Ser Ser Glu Ser Asp Phe Arg Gln Val Arg           
            420                 425                 430                   

aga agt gaa gcc tca aag agg ttt gaa tcc agc agt ggt ctc cca ggg       1824
Arg Ser Glu Ala Ser Lys Arg Phe Glu Ser Ser Ser Gly Leu Pro Gly           
        435                 440                 445                       

gta gat gaa acc tta agt caa ggc cag tca cag aga ccg agc aga caa       1872
Val Asp Glu Thr Leu Ser Gln Gly Gln Ser Gln Arg Pro Ser Arg Gln           
    450                 455                 460                           

tat gaa aca ccc ttt gaa ggc aac tta att aat caa gag atc atg cta       1920
Tyr Glu Thr Pro Phe Glu Gly Asn Leu Ile Asn Gln Glu Ile Met Leu           
465                 470                 475                 480           

aaa cgg caa gag gaa gaa ctg atg cag cta caa gcc aaa atg gcc ctt       1968
Lys Arg Gln Glu Glu Glu Leu Met Gln Leu Gln Ala Lys Met Ala Leu           
                485                 490                 495               

aga cag tct cgg ttg agc cta tat cca gga gac aca atc aaa gcg tcc       2016
Arg Gln Ser Arg Leu Ser Leu Tyr Pro Gly Asp Thr Ile Lys Ala Ser           
            500                 505                 510                   

atg ctt gac atc acc agg gat ccg tta aga gaa att gcc cta gaa aca       2064
Met Leu Asp Ile Thr Arg Asp Pro Leu Arg Glu Ile Ala Leu Glu Thr           
        515                 520                 525                       

gcc atg act caa aga aaa ctg agg aat ttc ttt ggc cct gag ttt gtg       2112
Ala Met Thr Gln Arg Lys Leu Arg Asn Phe Phe Gly Pro Glu Phe Val           
    530                 535                 540                           

aaa atg aca att gaa cca ttt ata tct ttg gat ttg cca cgg tct att       2160
Lys Met Thr Ile Glu Pro Phe Ile Ser Leu Asp Leu Pro Arg Ser Ile           
545                 550                 555                 560           

ctt act aag aaa ggg aag aat gag gat aac cga agg aaa gta aac ata       2208
Leu Thr Lys Lys Gly Lys Asn Glu Asp Asn Arg Arg Lys Val Asn Ile           
                565                 570                 575               

atg ctt ctg aac ggg caa aga ctg gaa ctg acc tgt gat acc aaa act       2256
Met Leu Leu Asn Gly Gln Arg Leu Glu Leu Thr Cys Asp Thr Lys Thr           
            580                 585                 590                   

ata tgt aaa gat gtg ttt gat atg gtt gtg gca cat att ggc tta gta       2304
Ile Cys Lys Asp Val Phe Asp Met Val Val Ala His Ile Gly Leu Val           
        595                 600                 605                       

gag cat cat ttg ttt gct tta gct acc ctc aaa gat aat gaa tat ttc       2352
Glu His His Leu Phe Ala Leu Ala Thr Leu Lys Asp Asn Glu Tyr Phe           
    610                 615                 620                           

ttt gtt gat cct gac tta aaa tta acc aaa gtg gcc cca gag gga tgg       2400
Phe Val Asp Pro Asp Leu Lys Leu Thr Lys Val Ala Pro Glu Gly Trp           
625                 630                 635                 640           

aaa gaa gaa cca aag aaa aag acc aaa gcc act gtt aat ttt act ttg       2448
Lys Glu Glu Pro Lys Lys Lys Thr Lys Ala Thr Val Asn Phe Thr Leu           
                645                 650                 655               

ttt ttc aga att aaa ttt ttt atg gat gat gtt agt cta ata caa cat       2496
Phe Phe Arg Ile Lys Phe Phe Met Asp Asp Val Ser Leu Ile Gln His           
            660                 665                 670                   

act ctg acg tgt cat cag tat tac ctt cag ctt cga aaa gat att ttg       2544
Thr Leu Thr Cys His Gln Tyr Tyr Leu Gln Leu Arg Lys Asp Ile Leu           
        675                 680                 685                       

gag gaa agg atg cac tgt gat gat gag act tcc tta ttg ctg gca tcc       2592
Glu Glu Arg Met His Cys Asp Asp Glu Thr Ser Leu Leu Leu Ala Ser           
    690                 695                 700                           

ttg gct ctc cag gct gag tat gga gat tat caa cca gag gtt cat ggt       2640
Leu Ala Leu Gln Ala Glu Tyr Gly Asp Tyr Gln Pro Glu Val His Gly           
705                 710                 715                 720           

gtg tct tac ttt aga atg gag cac tat ttg ccc gcc aga gtg atg gag       2688
Val Ser Tyr Phe Arg Met Glu His Tyr Leu Pro Ala Arg Val Met Glu           
                725                 730                 735               

aaa ctt gat tta tcc tat atc aaa gaa gag tta ccc aaa ttg cat aat       2736
Lys Leu Asp Leu Ser Tyr Ile Lys Glu Glu Leu Pro Lys Leu His Asn           
            740                 745                 750                   

acc tat gtg gga gct tct gaa aaa gag aca gag tta gaa ttt tta aag       2784
Thr Tyr Val Gly Ala Ser Glu Lys Glu Thr Glu Leu Glu Phe Leu Lys           
        755                 760                 765                       

gtc tgc caa aga ctg aca gaa tat gga gtt cat ttt cac cga gtg cac       2832
Val Cys Gln Arg Leu Thr Glu Tyr Gly Val His Phe His Arg Val His           
    770                 775                 780                           

cct gag aag aag tca caa aca gga ata ttg ctt gga gtc tgt tct aaa       2880
Pro Glu Lys Lys Ser Gln Thr Gly Ile Leu Leu Gly Val Cys Ser Lys           
785                 790                 795                 800           

ggt gtc ctt gtg ttt gaa gtt cac aat gga gtg cgc aca ttg gtc ctt       2928
Gly Val Leu Val Phe Glu Val His Asn Gly Val Arg Thr Leu Val Leu           
                805                 810                 815               

cgc ttt cca tgg agg gaa acc aag aaa ata tct ttt tct aaa aag aaa       2976
Arg Phe Pro Trp Arg Glu Thr Lys Lys Ile Ser Phe Ser Lys Lys Lys           
            820                 825                 830                   

atc aca ttg caa aat aca tca gat gga ata aaa cat ggc ttc cag aca       3024
Ile Thr Leu Gln Asn Thr Ser Asp Gly Ile Lys His Gly Phe Gln Thr           
        835                 840                 845                       

gac aac agt aag ata tgc cag tac ctg ctg cac ctc tgc tct tac cag       3072
Asp Asn Ser Lys Ile Cys Gln Tyr Leu Leu His Leu Cys Ser Tyr Gln           
    850                 855                 860                           

cat aag ttc cag cta cag atg aga gca aga cag agc aac caa gat gcc       3120
His Lys Phe Gln Leu Gln Met Arg Ala Arg Gln Ser Asn Gln Asp Ala           
865                 870                 875                 880           

caa gat att gag aga gct tcg ttt agg agc ctg aat ctc caa gca gag       3168
Gln Asp Ile Glu Arg Ala Ser Phe Arg Ser Leu Asn Leu Gln Ala Glu           
                885                 890                 895               

tct gtt aga gga ttt aat atg gga cga gca atc agc act ggc agt ctg       3216
Ser Val Arg Gly Phe Asn Met Gly Arg Ala Ile Ser Thr Gly Ser Leu           
            900                 905                 910                   

gcc agc agc acc ctc aac aaa ctt gct gtt cga cct tta tca gtt caa       3264
Ala Ser Ser Thr Leu Asn Lys Leu Ala Val Arg Pro Leu Ser Val Gln           
        915                 920                 925                       

gct gag att ctg aag agg cta tcc tgc tca gag ctg tcg ctt tac cag       3312
Ala Glu Ile Leu Lys Arg Leu Ser Cys Ser Glu Leu Ser Leu Tyr Gln           
    930                 935                 940                           

cca ttg caa aac agt tca aaa gag aag aat gac aaa gct tca tgg gag       3360
Pro Leu Gln Asn Ser Ser Lys Glu Lys Asn Asp Lys Ala Ser Trp Glu           
945                 950                 955                 960           

gaa aag cct aga gag atg agt aaa tca tac cat gat ctc agt cag gcc       3408
Glu Lys Pro Arg Glu Met Ser Lys Ser Tyr His Asp Leu Ser Gln Ala           
                965                 970                 975               

tct ctc tat cca cat cgg aaa aat gtc att gtt aac atg gaa ccc cca       3456
Ser Leu Tyr Pro His Arg Lys Asn Val Ile Val Asn Met Glu Pro Pro           
            980                 985                 990                   

cca caa acc gtt gca gag ttg gtg  gga aaa cct tct cac  cag atg tca     3504
Pro Gln Thr Val Ala Glu Leu Val  Gly Lys Pro Ser His  Gln Met Ser         
        995                 1000                 1005                     

aga tct  gat gca gaa tct ttg  gca gga gtg aca aaa  ctt aat aat        3549
Arg Ser  Asp Ala Glu Ser Leu  Ala Gly Val Thr Lys  Leu Asn Asn            
    1010                 1015                 1020                        

tca aag  tct gtt gcg agt tta  aat aga agt cct gaa  agg agg aaa        3594
Ser Lys  Ser Val Ala Ser Leu  Asn Arg Ser Pro Glu  Arg Arg Lys            
    1025                 1030                 1035                        

cat gaa  tca gac tcc tca tcc  att gaa gac cct ggg  caa gca tat        3639
His Glu  Ser Asp Ser Ser Ser  Ile Glu Asp Pro Gly  Gln Ala Tyr            
    1040                 1045                 1050                        

gtt cta  gga atg act atg cat  agt tct gga aac tct  tca tcc caa        3684
Val Leu  Gly Met Thr Met His  Ser Ser Gly Asn Ser  Ser Ser Gln            
    1055                 1060                 1065                        

gta ccc  tta aaa gaa aat gat  gtg cta cac aaa aga  tgg agc ata        3729
Val Pro  Leu Lys Glu Asn Asp  Val Leu His Lys Arg  Trp Ser Ile            
    1070                 1075                 1080                        

gta tct  tca cca gaa agg gag  atc acc tta gtg aac  ctg aaa aaa        3774
Val Ser  Ser Pro Glu Arg Glu  Ile Thr Leu Val Asn  Leu Lys Lys            
    1085                 1090                 1095                        

gat gca  aag tat ggc ttg gga  ttt caa att att ggt  ggg gag aag        3819
Asp Ala  Lys Tyr Gly Leu Gly  Phe Gln Ile Ile Gly  Gly Glu Lys            
    1100                 1105                 1110                        

atg gga  aga ctg gac cta ggc  ata ttt atc agt tca  gtt gcc cct        3864
Met Gly  Arg Leu Asp Leu Gly  Ile Phe Ile Ser Ser  Val Ala Pro            
    1115                 1120                 1125                        

gga gga  cca gct gac ttg gat  gga tgc ttg aag cca  gga gac cgt        3909
Gly Gly  Pro Ala Asp Leu Asp  Gly Cys Leu Lys Pro  Gly Asp Arg            
    1130                 1135                 1140                        

ttg ata  tct gtg aat agt gtg  agt ctg gag gga gtc  agc cac cat        3954
Leu Ile  Ser Val Asn Ser Val  Ser Leu Glu Gly Val  Ser His His            
    1145                 1150                 1155                        

gct gca  att gaa att ttg caa  aat gca cct gaa gat  gtg aca ctt        3999
Ala Ala  Ile Glu Ile Leu Gln  Asn Ala Pro Glu Asp  Val Thr Leu            
    1160                 1165                 1170                        

gtt atc  tct cag cca aaa gaa  aag ata tcc aaa gtg  cct tct act        4044
Val Ile  Ser Gln Pro Lys Glu  Lys Ile Ser Lys Val  Pro Ser Thr            
    1175                 1180                 1185                        

cct gtg  cat ctc acc aat gag  atg aaa aac tac atg  aag aaa tct        4089
Pro Val  His Leu Thr Asn Glu  Met Lys Asn Tyr Met  Lys Lys Ser            
    1190                 1195                 1200                        

tcc tac  atg caa gac agt gct  ata gat tct tct tcc  aag gat cac        4134
Ser Tyr  Met Gln Asp Ser Ala  Ile Asp Ser Ser Ser  Lys Asp His            
    1205                 1210                 1215                        

cac tgg  tca cgt ggt acc ctg  agg cac atc tcg gag  aac tcc ttt        4179
His Trp  Ser Arg Gly Thr Leu  Arg His Ile Ser Glu  Asn Ser Phe            
    1220                 1225                 1230                        

ggg cca  tct ggg ggc ctg cgg  gaa gga agc ctg agt  tct caa gat        4224
Gly Pro  Ser Gly Gly Leu Arg  Glu Gly Ser Leu Ser  Ser Gln Asp            
    1235                 1240                 1245                        

tcc agg  act gag agt gcc agc  ttg tct caa agc cag  gtc aat ggt        4269
Ser Arg  Thr Glu Ser Ala Ser  Leu Ser Gln Ser Gln  Val Asn Gly            
    1250                 1255                 1260                        

ttc ttt  gcc agc cat tta ggt  gac caa acc tgg cag  gaa tca cag        4314
Phe Phe  Ala Ser His Leu Gly  Asp Gln Thr Trp Gln  Glu Ser Gln            
    1265                 1270                 1275                        

cat ggc  agc cct tcc cca tct  gta ata tcc aaa gcc  acc gag aaa        4359
His Gly  Ser Pro Ser Pro Ser  Val Ile Ser Lys Ala  Thr Glu Lys            
    1280                 1285                 1290                        

gag act  ttc act gat agt aac  caa agc aaa act aaa  aag cca ggc        4404
Glu Thr  Phe Thr Asp Ser Asn  Gln Ser Lys Thr Lys  Lys Pro Gly            
    1295                 1300                 1305                        

att tct  gat gta act gat tac  tca gac cgt gga gat  tca gac atg        4449
Ile Ser  Asp Val Thr Asp Tyr  Ser Asp Arg Gly Asp  Ser Asp Met            
    1310                 1315                 1320                        

gat gaa  gcc act tac tcc agc  agt cag gat cat caa  aca cca aaa        4494
Asp Glu  Ala Thr Tyr Ser Ser  Ser Gln Asp His Gln  Thr Pro Lys            
    1325                 1330                 1335                        

cag gaa  tct tcc tct tca gtg  aat aca tcc aac aag  atg aat ttt        4539
Gln Glu  Ser Ser Ser Ser Val  Asn Thr Ser Asn Lys  Met Asn Phe            
    1340                 1345                 1350                        

aaa act  ttt tct tca tca cct  cct aag cct gga gat  atc ttt gag        4584
Lys Thr  Phe Ser Ser Ser Pro  Pro Lys Pro Gly Asp  Ile Phe Glu            
    1355                 1360                 1365                        

gtt gaa  ctg gct aaa aat gat  aac agc ttg ggg ata  agt gtc acg        4629
Val Glu  Leu Ala Lys Asn Asp  Asn Ser Leu Gly Ile  Ser Val Thr            
    1370                 1375                 1380                        

gta ctg  ttt gac aag gga ggt  gtg aat acg agt gtc  aga cat ggt        4674
Val Leu  Phe Asp Lys Gly Gly  Val Asn Thr Ser Val  Arg His Gly            
    1385                 1390                 1395                        

ggc att  tat gtg aaa gct gtt  att ccc cag gga gca  gca gag tct        4719
Gly Ile  Tyr Val Lys Ala Val  Ile Pro Gln Gly Ala  Ala Glu Ser            
    1400                 1405                 1410                        

gat ggt  aga att cac aaa ggt  gat cgc gtc cta gct  gtc aat gga        4764
Asp Gly  Arg Ile His Lys Gly  Asp Arg Val Leu Ala  Val Asn Gly            
    1415                 1420                 1425                        

gtt agt  cta gaa gga gcc acc  cat aag caa gct gtg  gaa aca ctg        4809
Val Ser  Leu Glu Gly Ala Thr  His Lys Gln Ala Val  Glu Thr Leu            
    1430                 1435                 1440                        

aga aat  aca gga cag gtg gtt  cat ctg tta tta gaa  aag gga caa        4854
Arg Asn  Thr Gly Gln Val Val  His Leu Leu Leu Glu  Lys Gly Gln            
    1445                 1450                 1455                        

tct cca  aca tct aaa gaa cat  gtc ccg gta acc cca  cag tgt acc        4899
Ser Pro  Thr Ser Lys Glu His  Val Pro Val Thr Pro  Gln Cys Thr            
    1460                 1465                 1470                        

ctt tca  gat cag aat gcc caa  ggt caa ggc cca gaa  aaa gtg aag        4944
Leu Ser  Asp Gln Asn Ala Gln  Gly Gln Gly Pro Glu  Lys Val Lys            
    1475                 1480                 1485                        

aaa aca  act cag gtc aaa gac  tac agc ttt gtc act  gaa gaa aat        4989
Lys Thr  Thr Gln Val Lys Asp  Tyr Ser Phe Val Thr  Glu Glu Asn            
    1490                 1495                 1500                        

aca ttt  gag gta aaa tta ttt  aaa aat agc tca ggt  cta gga ttc        5034
Thr Phe  Glu Val Lys Leu Phe  Lys Asn Ser Ser Gly  Leu Gly Phe            
    1505                 1510                 1515                        

agt ttt  tct cga gaa gat aat  ctt ata ccg gag caa  att aat gcc        5079
Ser Phe  Ser Arg Glu Asp Asn  Leu Ile Pro Glu Gln  Ile Asn Ala            
    1520                 1525                 1530                        

agc ata  gta agg gtt aaa aag  ctc ttt cct gga cag  cca gca gca        5124
Ser Ile  Val Arg Val Lys Lys  Leu Phe Pro Gly Gln  Pro Ala Ala            
    1535                 1540                 1545                        

gaa agt  gga aaa att gat gta  gga gat gtt atc ttg  aaa gtg aat        5169
Glu Ser  Gly Lys Ile Asp Val  Gly Asp Val Ile Leu  Lys Val Asn            
    1550                 1555                 1560                        

gga gcc  tct ttg aaa gga cta  tct cag cag gaa gtc  ata tct gct        5214
Gly Ala  Ser Leu Lys Gly Leu  Ser Gln Gln Glu Val  Ile Ser Ala            
    1565                 1570                 1575                        

ctc agg  gga act gct cca gaa  gta ttc ttg ctt ctc  tgc aga cct        5259
Leu Arg  Gly Thr Ala Pro Glu  Val Phe Leu Leu Leu  Cys Arg Pro            
    1580                 1585                 1590                        

cca cct  ggt gtg cta ccg gaa  att gat act gcg ctt  ttg acc cca        5304
Pro Pro  Gly Val Leu Pro Glu  Ile Asp Thr Ala Leu  Leu Thr Pro            
    1595                 1600                 1605                        

ctt cag  tct cca gca caa gta  ctt cca aac agc agt  aaa gac tct        5349
Leu Gln  Ser Pro Ala Gln Val  Leu Pro Asn Ser Ser  Lys Asp Ser            
    1610                 1615                 1620                        

tct cag  cca tca tgt gtg gag  caa agc acc agc tca  gat gaa aat        5394
Ser Gln  Pro Ser Cys Val Glu  Gln Ser Thr Ser Ser  Asp Glu Asn            
    1625                 1630                 1635                        

gaa atg  tca gac aaa agc aaa  aaa cag tgc aag tcc  cca tcc aga        5439
Glu Met  Ser Asp Lys Ser Lys  Lys Gln Cys Lys Ser  Pro Ser Arg            
    1640                 1645                 1650                        

aga gac  agt tac agt gac agc  agt ggg agt gga gaa  gat gac tta        5484
Arg Asp  Ser Tyr Ser Asp Ser  Ser Gly Ser Gly Glu  Asp Asp Leu            
    1655                 1660                 1665                        

gtg aca  gct cca gca aac ata  tca aat tcg acc tgg  agt tca gct        5529
Val Thr  Ala Pro Ala Asn Ile  Ser Asn Ser Thr Trp  Ser Ser Ala            
    1670                 1675                 1680                        

ttg cat  cag act cta agc aac  atg gta tca cag gca  cag agt cat        5574
Leu His  Gln Thr Leu Ser Asn  Met Val Ser Gln Ala  Gln Ser His            
    1685                 1690                 1695                        

cat gaa  gca ccc aag agt caa  gaa gat acc att tgt  acc atg ttt        5619
His Glu  Ala Pro Lys Ser Gln  Glu Asp Thr Ile Cys  Thr Met Phe            
    1700                 1705                 1710                        

tac tat  cct cag aaa att ccc  aat aaa cca gag ttt  gag gac agt        5664
Tyr Tyr  Pro Gln Lys Ile Pro  Asn Lys Pro Glu Phe  Glu Asp Ser            
    1715                 1720                 1725                        

aat cct  tcc cct cta cca ccg  gat atg gct cct ggg  cag agt tat        5709
Asn Pro  Ser Pro Leu Pro Pro  Asp Met Ala Pro Gly  Gln Ser Tyr            
    1730                 1735                 1740                        

caa ccc  caa tca gaa tct gct  tcc tct agt tcg atg  gat aag tat        5754
Gln Pro  Gln Ser Glu Ser Ala  Ser Ser Ser Ser Met  Asp Lys Tyr            
    1745                 1750                 1755                        

cat ata  cat cac att tct gaa  cca act aga caa gaa  aac tgg aca        5799
His Ile  His His Ile Ser Glu  Pro Thr Arg Gln Glu  Asn Trp Thr            
    1760                 1765                 1770                        

cct ttg  aaa aat gac ttg gaa  aat cac ctt gaa gac  ttt gaa ctg        5844
Pro Leu  Lys Asn Asp Leu Glu  Asn His Leu Glu Asp  Phe Glu Leu            
    1775                 1780                 1785                        

gaa gta  gaa ctc ctc att acc  cta att aaa tca gaa  aaa gga agc        5889
Glu Val  Glu Leu Leu Ile Thr  Leu Ile Lys Ser Glu  Lys Gly Ser            
    1790                 1795                 1800                        

ctg ggt  ttt aca gta acc aaa  ggc aat cag aga att  ggt tgt tat        5934
Leu Gly  Phe Thr Val Thr Lys  Gly Asn Gln Arg Ile  Gly Cys Tyr            
    1805                 1810                 1815                        

gtt cat  gat gtc ata cag gat  cca gcc aaa agt gat  gga agg cta        5979
Val His  Asp Val Ile Gln Asp  Pro Ala Lys Ser Asp  Gly Arg Leu            
    1820                 1825                 1830                        

aaa cct  ggg gac cgg ctc ata  aag gtt aat gat aca  gat gtt act        6024
Lys Pro  Gly Asp Arg Leu Ile  Lys Val Asn Asp Thr  Asp Val Thr            
    1835                 1840                 1845                        

aat atg  act cat aca gat gca  gtt aat ctg ctc cgg  gct gca tcc        6069
Asn Met  Thr His Thr Asp Ala  Val Asn Leu Leu Arg  Ala Ala Ser            
    1850                 1855                 1860                        

aaa aca  gtc aga tta gtt att  gga cga gtt cta gaa  tta ccc aga        6114
Lys Thr  Val Arg Leu Val Ile  Gly Arg Val Leu Glu  Leu Pro Arg            
    1865                 1870                 1875                        

ata cca  atg ttg cct cat ttg  cta ccg gac ata aca  cta acg tgc        6159
Ile Pro  Met Leu Pro His Leu  Leu Pro Asp Ile Thr  Leu Thr Cys            
    1880                 1885                 1890                        

aac aaa  gag gag ttg ggt ttt  tcc tta tgt gga ggt  cat gac agc        6204
Asn Lys  Glu Glu Leu Gly Phe  Ser Leu Cys Gly Gly  His Asp Ser            
    1895                 1900                 1905                        

ctt tat  caa gtg gta tat att  agt gat att aat cca  agg tcc gtc        6249
Leu Tyr  Gln Val Val Tyr Ile  Ser Asp Ile Asn Pro  Arg Ser Val            
    1910                 1915                 1920                        

gca gcc  att gag ggt aat ctc  cag cta tta gat gtc  atc cat tat        6294
Ala Ala  Ile Glu Gly Asn Leu  Gln Leu Leu Asp Val  Ile His Tyr            
    1925                 1930                 1935                        

gtg aac  gga gtc agc aca caa  gga atg acc ttg gag  gaa gtt aac        6339
Val Asn  Gly Val Ser Thr Gln  Gly Met Thr Leu Glu  Glu Val Asn            
    1940                 1945                 1950                        

aga gca  tta gac atg tca ctt  cct tca ttg gta ttg  aaa gca aca        6384
Arg Ala  Leu Asp Met Ser Leu  Pro Ser Leu Val Leu  Lys Ala Thr            
    1955                 1960                 1965                        

aga aat  gat ctt cca gtg gtc  ccc agc tca aag agg  tct gct gtt        6429
Arg Asn  Asp Leu Pro Val Val  Pro Ser Ser Lys Arg  Ser Ala Val            
    1970                 1975                 1980                        

tca gct  cca aag tca acc aaa  ggc aat ggt tcc tac  agt gtg ggg        6474
Ser Ala  Pro Lys Ser Thr Lys  Gly Asn Gly Ser Tyr  Ser Val Gly            
    1985                 1990                 1995                        

tct tgc  agc cag cct gcc ctc  act cct aat gat tca  ttc tcc acg        6519
Ser Cys  Ser Gln Pro Ala Leu  Thr Pro Asn Asp Ser  Phe Ser Thr            
    2000                 2005                 2010                        

gtt gct  ggg gaa gaa ata aat  gaa ata tcg tac ccc  aaa gga aaa        6564
Val Ala  Gly Glu Glu Ile Asn  Glu Ile Ser Tyr Pro  Lys Gly Lys            
    2015                 2020                 2025                        

tgt tct  act tat cag ata aag  gga tca cca aac ttg  act ctg ccc        6609
Cys Ser  Thr Tyr Gln Ile Lys  Gly Ser Pro Asn Leu  Thr Leu Pro            
    2030                 2035                 2040                        

aaa gaa  tct tat ata caa gaa  gat gac att tat gat  gat tcc caa        6654
Lys Glu  Ser Tyr Ile Gln Glu  Asp Asp Ile Tyr Asp  Asp Ser Gln            
    2045                 2050                 2055                        

gaa gct  gaa gtt atc cag tct  ctg ctg gat gtt gtg  gat gag gaa        6699
Glu Ala  Glu Val Ile Gln Ser  Leu Leu Asp Val Val  Asp Glu Glu            
    2060                 2065                 2070                        

gcc cag  aat ctt tta aac gaa  aat aat gca gca gga  tac tcc tgt        6744
Ala Gln  Asn Leu Leu Asn Glu  Asn Asn Ala Ala Gly  Tyr Ser Cys            
    2075                 2080                 2085                        

ggt cca  ggt aca tta aag atg  aat ggg aag tta tca  gaa gag aga        6789
Gly Pro  Gly Thr Leu Lys Met  Asn Gly Lys Leu Ser  Glu Glu Arg            
    2090                 2095                 2100                        

aca gaa  gat aca gac tgc gat  ggt tca cct tta cct  gag tat ttt        6834
Thr Glu  Asp Thr Asp Cys Asp  Gly Ser Pro Leu Pro  Glu Tyr Phe            
    2105                 2110                 2115                        

act gag  gcc acc aaa atg aat  ggc tgt gaa gaa tat  tgt gaa gaa        6879
Thr Glu  Ala Thr Lys Met Asn  Gly Cys Glu Glu Tyr  Cys Glu Glu            
    2120                 2125                 2130                        

aaa gta  aaa agt gaa agc tta  att cag aag cca caa  gaa aag aag        6924
Lys Val  Lys Ser Glu Ser Leu  Ile Gln Lys Pro Gln  Glu Lys Lys            
    2135                 2140                 2145                        

act gat  gat gat gaa ata aca  tgg gga aat gat gag  ttg cca ata        6969
Thr Asp  Asp Asp Glu Ile Thr  Trp Gly Asn Asp Glu  Leu Pro Ile            
    2150                 2155                 2160                        

gag aga  aca aac cat gaa gat  tct gat aaa gat cat  tcc ttt ctg        7014
Glu Arg  Thr Asn His Glu Asp  Ser Asp Lys Asp His  Ser Phe Leu            
    2165                 2170                 2175                        

aca aac  gat gag ctc gct gta  ctc cct gtc gtc aaa  gtg ctt ccc        7059
Thr Asn  Asp Glu Leu Ala Val  Leu Pro Val Val Lys  Val Leu Pro            
    2180                 2185                 2190                        

tct ggt  aaa tac acg ggt gcc  aac tta aaa tca gtc  att cga gtc        7104
Ser Gly  Lys Tyr Thr Gly Ala  Asn Leu Lys Ser Val  Ile Arg Val            
    2195                 2200                 2205                        

ctg cgg  ggt ttg cta gat caa  gga att cct tct aag  gag ctg gag        7149
Leu Arg  Gly Leu Leu Asp Gln  Gly Ile Pro Ser Lys  Glu Leu Glu            
    2210                 2215                 2220                        

aat ctt  caa gaa tta aaa cct  ttg gat cag tgt cta  att ggg caa        7194
Asn Leu  Gln Glu Leu Lys Pro  Leu Asp Gln Cys Leu  Ile Gly Gln            
    2225                 2230                 2235                        

act aag  gaa aac aga agg aag  aac aga tat aaa aat  ata ctt ccc        7239
Thr Lys  Glu Asn Arg Arg Lys  Asn Arg Tyr Lys Asn  Ile Leu Pro            
    2240                 2245                 2250                        

tat gat  gct aca aga gtg cct  ctt gga gat gaa ggt  ggc tat atc        7284
Tyr Asp  Ala Thr Arg Val Pro  Leu Gly Asp Glu Gly  Gly Tyr Ile            
    2255                 2260                 2265                        

aat gcc  agc ttc att aag ata  cca gtt ggg aaa gaa  gag ttc gtt        7329
Asn Ala  Ser Phe Ile Lys Ile  Pro Val Gly Lys Glu  Glu Phe Val            
    2270                 2275                 2280                        

tac att  gcc tgc caa gga cca  ctg cct aca act gtt  gga gac ttc        7374
Tyr Ile  Ala Cys Gln Gly Pro  Leu Pro Thr Thr Val  Gly Asp Phe            
    2285                 2290                 2295                        

tgg cag  atg att tgg gag caa  aaa tcc aca gtg ata  gcc atg atg        7419
Trp Gln  Met Ile Trp Glu Gln  Lys Ser Thr Val Ile  Ala Met Met            
    2300                 2305                 2310                        

act caa  gaa gta gaa gga gaa  aaa atc aaa tgc cag  cgc tat tgg        7464
Thr Gln  Glu Val Glu Gly Glu  Lys Ile Lys Cys Gln  Arg Tyr Trp            
    2315                 2320                 2325                        

ccc aac  atc cta ggc aaa aca  aca atg gtc agc aac  aga ctt cga        7509
Pro Asn  Ile Leu Gly Lys Thr  Thr Met Val Ser Asn  Arg Leu Arg            
    2330                 2335                 2340                        

ctg gct  ctt gtg aga atg cag  cag ctg aag ggc ttt  gtg gtg agg        7554
Leu Ala  Leu Val Arg Met Gln  Gln Leu Lys Gly Phe  Val Val Arg            
    2345                 2350                 2355                        

gca atg  acc ctt gaa gat att  cag acc aga gag gtg  cgc cat att        7599
Ala Met  Thr Leu Glu Asp Ile  Gln Thr Arg Glu Val  Arg His Ile            
    2360                 2365                 2370                        

tct cat  ctg aat ttc act gcc  tgg cca gac cat gat  aca cct tct        7644
Ser His  Leu Asn Phe Thr Ala  Trp Pro Asp His Asp  Thr Pro Ser            
    2375                 2380                 2385                        

caa cca  gat gat ctg ctt act  ttt atc tcc tac atg  aga cac atc        7689
Gln Pro  Asp Asp Leu Leu Thr  Phe Ile Ser Tyr Met  Arg His Ile            
    2390                 2395                 2400                        

cac aga  tca ggc cca atc att  acg cac tgc agt gct  ggc att gga        7734
His Arg  Ser Gly Pro Ile Ile  Thr His Cys Ser Ala  Gly Ile Gly            
    2405                 2410                 2415                        

cgt tca  ggg acc ctg att tgc  ata gat gtg gtt ctg  gga tta atc        7779
Arg Ser  Gly Thr Leu Ile Cys  Ile Asp Val Val Leu  Gly Leu Ile            
    2420                 2425                 2430                        

agt cag  gat ctt gat ttt gac  atc tct gat ttg gtg  cgc tgc atg        7824
Ser Gln  Asp Leu Asp Phe Asp  Ile Ser Asp Leu Val  Arg Cys Met            
    2435                 2440                 2445                        

aga cta  caa aga cac gga atg  gtt cag aca gag gat  caa tat att        7869
Arg Leu  Gln Arg His Gly Met  Val Gln Thr Glu Asp  Gln Tyr Ile            
    2450                 2455                 2460                        

ttc tgc  tat caa gtc atc ctt  tat gtc ctg aca cgt  ctt caa gca        7914
Phe Cys  Tyr Gln Val Ile Leu  Tyr Val Leu Thr Arg  Leu Gln Ala            
    2465                 2470                 2475                        

gaa gaa  gag caa aaa cag cag  cct cag ctt ctg aag  tga catgaaaaga     7963
Glu Glu  Glu Gln Lys Gln Gln  Pro Gln Leu Leu Lys                         
    2480                 2485                 2490                        

gcctctggat gcatttccat ttctctcctt aacctccagc agactcctgc tctctatcca     8023

aaataaagat cacagagcag caagttcata caacatgcat gttctcctct atcttagagg     8083

ggtattcttc ttgaaaataa aaaatattga aatgctgtat ttttacagct actttaacct     8143

atgataatta tttacaaaat tttaacacta accaaacaat gcagatctta gggatgatta     8203

aaggcagcat ttgatgatag cagacattgt tacaaggaca tggtgagtct atttttaatg     8263

caccaatctt gtttatagca aaaatgtttt ccaatatttt aataaagtag ttattttata     8323

ggggatactt gaaaccagta tttaagcttt aaatgacagt aatattggca tagaaaaaag     8383

tagcaaatgt ttactgtatc aatttctaat gtttactata tagaatttcc tgtaatatat     8443

ttatatactt tttcatgaaa atggagttat cagttatctg tttgttactg catcatctgt     8503

ttgtaatcat tatctcactt tgtaaataaa aacacacctt aaaacatgaa caagccaaaa     8563

ctgtgtgcag acaaaaaaaa aaaaa                                           8588


<210>  14
<211>  2490
<212>  PRT
<213>  Homo sapiens

<400>  14

Met His Val Ser Leu Ala Glu Ala Leu Glu Val Arg Gly Gly Pro Leu 
1               5                   10                  15      


Gln Glu Glu Glu Ile Trp Ala Val Leu Asn Gln Ser Ala Glu Ser Leu 
            20                  25                  30          


Gln Glu Leu Phe Arg Lys Val Ser Leu Ala Asp Pro Ala Ala Leu Gly 
        35                  40                  45              


Phe Ile Ile Ser Pro Trp Ser Leu Leu Leu Leu Pro Ser Gly Ser Val 
    50                  55                  60                  


Ser Phe Thr Asp Glu Asn Ile Ser Asn Gln Asp Leu Arg Ala Phe Thr 
65                  70                  75                  80  


Ala Pro Glu Val Leu Gln Asn Gln Ser Leu Thr Ser Leu Ser Asp Val 
                85                  90                  95      


Glu Lys Ile His Ile Tyr Ser Leu Gly Met Thr Leu Tyr Trp Gly Ala 
            100                 105                 110         


Asp Tyr Glu Val Pro Gln Ser Gln Pro Ile Lys Leu Gly Asp His Leu 
        115                 120                 125             


Asn Ser Ile Leu Leu Gly Met Cys Glu Asp Val Ile Tyr Ala Arg Val 
    130                 135                 140                 


Ser Val Arg Thr Val Leu Asp Ala Cys Ser Ala His Ile Arg Asn Ser 
145                 150                 155                 160 


Asn Cys Ala Pro Ser Phe Ser Tyr Val Lys His Leu Val Lys Leu Val 
                165                 170                 175     


Leu Gly Asn Leu Ser Gly Thr Asp Gln Leu Ser Cys Asn Ser Glu Gln 
            180                 185                 190         


Lys Pro Asp Arg Ser Gln Ala Ile Arg Asp Arg Leu Arg Gly Lys Gly 
        195                 200                 205             


Leu Pro Thr Gly Arg Ser Ser Thr Ser Asp Val Leu Asp Ile Gln Lys 
    210                 215                 220                 


Pro Pro Leu Ser His Gln Thr Phe Leu Asn Lys Gly Leu Ser Lys Ser 
225                 230                 235                 240 


Met Gly Phe Leu Ser Ile Lys Asp Thr Gln Asp Glu Asn Tyr Phe Lys 
                245                 250                 255     


Asp Ile Leu Ser Asp Asn Ser Gly Arg Glu Asp Ser Glu Asn Thr Phe 
            260                 265                 270         


Ser Pro Tyr Gln Phe Lys Thr Ser Gly Pro Glu Lys Lys Pro Ile Pro 
        275                 280                 285             


Gly Ile Asp Val Leu Ser Lys Lys Lys Ile Trp Ala Ser Ser Met Asp 
    290                 295                 300                 


Leu Leu Cys Thr Ala Asp Arg Asp Phe Ser Ser Gly Glu Thr Ala Thr 
305                 310                 315                 320 


Tyr Arg Arg Cys His Pro Glu Ala Val Thr Val Arg Thr Ser Thr Thr 
                325                 330                 335     


Pro Arg Lys Lys Glu Ala Arg Tyr Ser Asp Gly Ser Ile Ala Leu Asp 
            340                 345                 350         


Ile Phe Gly Pro Gln Lys Met Asp Pro Ile Tyr His Thr Arg Glu Leu 
        355                 360                 365             


Pro Thr Ser Ser Ala Ile Ser Ser Ala Leu Asp Arg Ile Arg Glu Arg 
    370                 375                 380                 


Gln Lys Lys Leu Gln Val Leu Arg Glu Ala Met Asn Val Glu Glu Pro 
385                 390                 395                 400 


Val Arg Arg Tyr Lys Thr Tyr His Gly Asp Val Phe Ser Thr Ser Ser 
                405                 410                 415     


Glu Ser Pro Ser Ile Ile Ser Ser Glu Ser Asp Phe Arg Gln Val Arg 
            420                 425                 430         


Arg Ser Glu Ala Ser Lys Arg Phe Glu Ser Ser Ser Gly Leu Pro Gly 
        435                 440                 445             


Val Asp Glu Thr Leu Ser Gln Gly Gln Ser Gln Arg Pro Ser Arg Gln 
    450                 455                 460                 


Tyr Glu Thr Pro Phe Glu Gly Asn Leu Ile Asn Gln Glu Ile Met Leu 
465                 470                 475                 480 


Lys Arg Gln Glu Glu Glu Leu Met Gln Leu Gln Ala Lys Met Ala Leu 
                485                 490                 495     


Arg Gln Ser Arg Leu Ser Leu Tyr Pro Gly Asp Thr Ile Lys Ala Ser 
            500                 505                 510         


Met Leu Asp Ile Thr Arg Asp Pro Leu Arg Glu Ile Ala Leu Glu Thr 
        515                 520                 525             


Ala Met Thr Gln Arg Lys Leu Arg Asn Phe Phe Gly Pro Glu Phe Val 
    530                 535                 540                 


Lys Met Thr Ile Glu Pro Phe Ile Ser Leu Asp Leu Pro Arg Ser Ile 
545                 550                 555                 560 


Leu Thr Lys Lys Gly Lys Asn Glu Asp Asn Arg Arg Lys Val Asn Ile 
                565                 570                 575     


Met Leu Leu Asn Gly Gln Arg Leu Glu Leu Thr Cys Asp Thr Lys Thr 
            580                 585                 590         


Ile Cys Lys Asp Val Phe Asp Met Val Val Ala His Ile Gly Leu Val 
        595                 600                 605             


Glu His His Leu Phe Ala Leu Ala Thr Leu Lys Asp Asn Glu Tyr Phe 
    610                 615                 620                 


Phe Val Asp Pro Asp Leu Lys Leu Thr Lys Val Ala Pro Glu Gly Trp 
625                 630                 635                 640 


Lys Glu Glu Pro Lys Lys Lys Thr Lys Ala Thr Val Asn Phe Thr Leu 
                645                 650                 655     


Phe Phe Arg Ile Lys Phe Phe Met Asp Asp Val Ser Leu Ile Gln His 
            660                 665                 670         


Thr Leu Thr Cys His Gln Tyr Tyr Leu Gln Leu Arg Lys Asp Ile Leu 
        675                 680                 685             


Glu Glu Arg Met His Cys Asp Asp Glu Thr Ser Leu Leu Leu Ala Ser 
    690                 695                 700                 


Leu Ala Leu Gln Ala Glu Tyr Gly Asp Tyr Gln Pro Glu Val His Gly 
705                 710                 715                 720 


Val Ser Tyr Phe Arg Met Glu His Tyr Leu Pro Ala Arg Val Met Glu 
                725                 730                 735     


Lys Leu Asp Leu Ser Tyr Ile Lys Glu Glu Leu Pro Lys Leu His Asn 
            740                 745                 750         


Thr Tyr Val Gly Ala Ser Glu Lys Glu Thr Glu Leu Glu Phe Leu Lys 
        755                 760                 765             


Val Cys Gln Arg Leu Thr Glu Tyr Gly Val His Phe His Arg Val His 
    770                 775                 780                 


Pro Glu Lys Lys Ser Gln Thr Gly Ile Leu Leu Gly Val Cys Ser Lys 
785                 790                 795                 800 


Gly Val Leu Val Phe Glu Val His Asn Gly Val Arg Thr Leu Val Leu 
                805                 810                 815     


Arg Phe Pro Trp Arg Glu Thr Lys Lys Ile Ser Phe Ser Lys Lys Lys 
            820                 825                 830         


Ile Thr Leu Gln Asn Thr Ser Asp Gly Ile Lys His Gly Phe Gln Thr 
        835                 840                 845             


Asp Asn Ser Lys Ile Cys Gln Tyr Leu Leu His Leu Cys Ser Tyr Gln 
    850                 855                 860                 


His Lys Phe Gln Leu Gln Met Arg Ala Arg Gln Ser Asn Gln Asp Ala 
865                 870                 875                 880 


Gln Asp Ile Glu Arg Ala Ser Phe Arg Ser Leu Asn Leu Gln Ala Glu 
                885                 890                 895     


Ser Val Arg Gly Phe Asn Met Gly Arg Ala Ile Ser Thr Gly Ser Leu 
            900                 905                 910         


Ala Ser Ser Thr Leu Asn Lys Leu Ala Val Arg Pro Leu Ser Val Gln 
        915                 920                 925             


Ala Glu Ile Leu Lys Arg Leu Ser Cys Ser Glu Leu Ser Leu Tyr Gln 
    930                 935                 940                 


Pro Leu Gln Asn Ser Ser Lys Glu Lys Asn Asp Lys Ala Ser Trp Glu 
945                 950                 955                 960 


Glu Lys Pro Arg Glu Met Ser Lys Ser Tyr His Asp Leu Ser Gln Ala 
                965                 970                 975     


Ser Leu Tyr Pro His Arg Lys Asn Val Ile Val Asn Met Glu Pro Pro 
            980                 985                 990         


Pro Gln Thr Val Ala Glu Leu Val  Gly Lys Pro Ser His  Gln Met Ser 
        995                 1000                 1005             


Arg Ser  Asp Ala Glu Ser Leu  Ala Gly Val Thr Lys  Leu Asn Asn 
    1010                 1015                 1020             


Ser Lys  Ser Val Ala Ser Leu  Asn Arg Ser Pro Glu  Arg Arg Lys 
    1025                 1030                 1035             


His Glu  Ser Asp Ser Ser Ser  Ile Glu Asp Pro Gly  Gln Ala Tyr 
    1040                 1045                 1050             


Val Leu  Gly Met Thr Met His  Ser Ser Gly Asn Ser  Ser Ser Gln 
    1055                 1060                 1065             


Val Pro  Leu Lys Glu Asn Asp  Val Leu His Lys Arg  Trp Ser Ile 
    1070                 1075                 1080             


Val Ser  Ser Pro Glu Arg Glu  Ile Thr Leu Val Asn  Leu Lys Lys 
    1085                 1090                 1095             


Asp Ala  Lys Tyr Gly Leu Gly  Phe Gln Ile Ile Gly  Gly Glu Lys 
    1100                 1105                 1110             


Met Gly  Arg Leu Asp Leu Gly  Ile Phe Ile Ser Ser  Val Ala Pro 
    1115                 1120                 1125             


Gly Gly  Pro Ala Asp Leu Asp  Gly Cys Leu Lys Pro  Gly Asp Arg 
    1130                 1135                 1140             


Leu Ile  Ser Val Asn Ser Val  Ser Leu Glu Gly Val  Ser His His 
    1145                 1150                 1155             


Ala Ala  Ile Glu Ile Leu Gln  Asn Ala Pro Glu Asp  Val Thr Leu 
    1160                 1165                 1170             


Val Ile  Ser Gln Pro Lys Glu  Lys Ile Ser Lys Val  Pro Ser Thr 
    1175                 1180                 1185             


Pro Val  His Leu Thr Asn Glu  Met Lys Asn Tyr Met  Lys Lys Ser 
    1190                 1195                 1200             


Ser Tyr  Met Gln Asp Ser Ala  Ile Asp Ser Ser Ser  Lys Asp His 
    1205                 1210                 1215             


His Trp  Ser Arg Gly Thr Leu  Arg His Ile Ser Glu  Asn Ser Phe 
    1220                 1225                 1230             


Gly Pro  Ser Gly Gly Leu Arg  Glu Gly Ser Leu Ser  Ser Gln Asp 
    1235                 1240                 1245             


Ser Arg  Thr Glu Ser Ala Ser  Leu Ser Gln Ser Gln  Val Asn Gly 
    1250                 1255                 1260             


Phe Phe  Ala Ser His Leu Gly  Asp Gln Thr Trp Gln  Glu Ser Gln 
    1265                 1270                 1275             


His Gly  Ser Pro Ser Pro Ser  Val Ile Ser Lys Ala  Thr Glu Lys 
    1280                 1285                 1290             


Glu Thr  Phe Thr Asp Ser Asn  Gln Ser Lys Thr Lys  Lys Pro Gly 
    1295                 1300                 1305             


Ile Ser  Asp Val Thr Asp Tyr  Ser Asp Arg Gly Asp  Ser Asp Met 
    1310                 1315                 1320             


Asp Glu  Ala Thr Tyr Ser Ser  Ser Gln Asp His Gln  Thr Pro Lys 
    1325                 1330                 1335             


Gln Glu  Ser Ser Ser Ser Val  Asn Thr Ser Asn Lys  Met Asn Phe 
    1340                 1345                 1350             


Lys Thr  Phe Ser Ser Ser Pro  Pro Lys Pro Gly Asp  Ile Phe Glu 
    1355                 1360                 1365             


Val Glu  Leu Ala Lys Asn Asp  Asn Ser Leu Gly Ile  Ser Val Thr 
    1370                 1375                 1380             


Val Leu  Phe Asp Lys Gly Gly  Val Asn Thr Ser Val  Arg His Gly 
    1385                 1390                 1395             


Gly Ile  Tyr Val Lys Ala Val  Ile Pro Gln Gly Ala  Ala Glu Ser 
    1400                 1405                 1410             


Asp Gly  Arg Ile His Lys Gly  Asp Arg Val Leu Ala  Val Asn Gly 
    1415                 1420                 1425             


Val Ser  Leu Glu Gly Ala Thr  His Lys Gln Ala Val  Glu Thr Leu 
    1430                 1435                 1440             


Arg Asn  Thr Gly Gln Val Val  His Leu Leu Leu Glu  Lys Gly Gln 
    1445                 1450                 1455             


Ser Pro  Thr Ser Lys Glu His  Val Pro Val Thr Pro  Gln Cys Thr 
    1460                 1465                 1470             


Leu Ser  Asp Gln Asn Ala Gln  Gly Gln Gly Pro Glu  Lys Val Lys 
    1475                 1480                 1485             


Lys Thr  Thr Gln Val Lys Asp  Tyr Ser Phe Val Thr  Glu Glu Asn 
    1490                 1495                 1500             


Thr Phe  Glu Val Lys Leu Phe  Lys Asn Ser Ser Gly  Leu Gly Phe 
    1505                 1510                 1515             


Ser Phe  Ser Arg Glu Asp Asn  Leu Ile Pro Glu Gln  Ile Asn Ala 
    1520                 1525                 1530             


Ser Ile  Val Arg Val Lys Lys  Leu Phe Pro Gly Gln  Pro Ala Ala 
    1535                 1540                 1545             


Glu Ser  Gly Lys Ile Asp Val  Gly Asp Val Ile Leu  Lys Val Asn 
    1550                 1555                 1560             


Gly Ala  Ser Leu Lys Gly Leu  Ser Gln Gln Glu Val  Ile Ser Ala 
    1565                 1570                 1575             


Leu Arg  Gly Thr Ala Pro Glu  Val Phe Leu Leu Leu  Cys Arg Pro 
    1580                 1585                 1590             


Pro Pro  Gly Val Leu Pro Glu  Ile Asp Thr Ala Leu  Leu Thr Pro 
    1595                 1600                 1605             


Leu Gln  Ser Pro Ala Gln Val  Leu Pro Asn Ser Ser  Lys Asp Ser 
    1610                 1615                 1620             


Ser Gln  Pro Ser Cys Val Glu  Gln Ser Thr Ser Ser  Asp Glu Asn 
    1625                 1630                 1635             


Glu Met  Ser Asp Lys Ser Lys  Lys Gln Cys Lys Ser  Pro Ser Arg 
    1640                 1645                 1650             


Arg Asp  Ser Tyr Ser Asp Ser  Ser Gly Ser Gly Glu  Asp Asp Leu 
    1655                 1660                 1665             


Val Thr  Ala Pro Ala Asn Ile  Ser Asn Ser Thr Trp  Ser Ser Ala 
    1670                 1675                 1680             


Leu His  Gln Thr Leu Ser Asn  Met Val Ser Gln Ala  Gln Ser His 
    1685                 1690                 1695             


His Glu  Ala Pro Lys Ser Gln  Glu Asp Thr Ile Cys  Thr Met Phe 
    1700                 1705                 1710             


Tyr Tyr  Pro Gln Lys Ile Pro  Asn Lys Pro Glu Phe  Glu Asp Ser 
    1715                 1720                 1725             


Asn Pro  Ser Pro Leu Pro Pro  Asp Met Ala Pro Gly  Gln Ser Tyr 
    1730                 1735                 1740             


Gln Pro  Gln Ser Glu Ser Ala  Ser Ser Ser Ser Met  Asp Lys Tyr 
    1745                 1750                 1755             


His Ile  His His Ile Ser Glu  Pro Thr Arg Gln Glu  Asn Trp Thr 
    1760                 1765                 1770             


Pro Leu  Lys Asn Asp Leu Glu  Asn His Leu Glu Asp  Phe Glu Leu 
    1775                 1780                 1785             


Glu Val  Glu Leu Leu Ile Thr  Leu Ile Lys Ser Glu  Lys Gly Ser 
    1790                 1795                 1800             


Leu Gly  Phe Thr Val Thr Lys  Gly Asn Gln Arg Ile  Gly Cys Tyr 
    1805                 1810                 1815             


Val His  Asp Val Ile Gln Asp  Pro Ala Lys Ser Asp  Gly Arg Leu 
    1820                 1825                 1830             


Lys Pro  Gly Asp Arg Leu Ile  Lys Val Asn Asp Thr  Asp Val Thr 
    1835                 1840                 1845             


Asn Met  Thr His Thr Asp Ala  Val Asn Leu Leu Arg  Ala Ala Ser 
    1850                 1855                 1860             


Lys Thr  Val Arg Leu Val Ile  Gly Arg Val Leu Glu  Leu Pro Arg 
    1865                 1870                 1875             


Ile Pro  Met Leu Pro His Leu  Leu Pro Asp Ile Thr  Leu Thr Cys 
    1880                 1885                 1890             


Asn Lys  Glu Glu Leu Gly Phe  Ser Leu Cys Gly Gly  His Asp Ser 
    1895                 1900                 1905             


Leu Tyr  Gln Val Val Tyr Ile  Ser Asp Ile Asn Pro  Arg Ser Val 
    1910                 1915                 1920             


Ala Ala  Ile Glu Gly Asn Leu  Gln Leu Leu Asp Val  Ile His Tyr 
    1925                 1930                 1935             


Val Asn  Gly Val Ser Thr Gln  Gly Met Thr Leu Glu  Glu Val Asn 
    1940                 1945                 1950             


Arg Ala  Leu Asp Met Ser Leu  Pro Ser Leu Val Leu  Lys Ala Thr 
    1955                 1960                 1965             


Arg Asn  Asp Leu Pro Val Val  Pro Ser Ser Lys Arg  Ser Ala Val 
    1970                 1975                 1980             


Ser Ala  Pro Lys Ser Thr Lys  Gly Asn Gly Ser Tyr  Ser Val Gly 
    1985                 1990                 1995             


Ser Cys  Ser Gln Pro Ala Leu  Thr Pro Asn Asp Ser  Phe Ser Thr 
    2000                 2005                 2010             


Val Ala  Gly Glu Glu Ile Asn  Glu Ile Ser Tyr Pro  Lys Gly Lys 
    2015                 2020                 2025             


Cys Ser  Thr Tyr Gln Ile Lys  Gly Ser Pro Asn Leu  Thr Leu Pro 
    2030                 2035                 2040             


Lys Glu  Ser Tyr Ile Gln Glu  Asp Asp Ile Tyr Asp  Asp Ser Gln 
    2045                 2050                 2055             


Glu Ala  Glu Val Ile Gln Ser  Leu Leu Asp Val Val  Asp Glu Glu 
    2060                 2065                 2070             


Ala Gln  Asn Leu Leu Asn Glu  Asn Asn Ala Ala Gly  Tyr Ser Cys 
    2075                 2080                 2085             


Gly Pro  Gly Thr Leu Lys Met  Asn Gly Lys Leu Ser  Glu Glu Arg 
    2090                 2095                 2100             


Thr Glu  Asp Thr Asp Cys Asp  Gly Ser Pro Leu Pro  Glu Tyr Phe 
    2105                 2110                 2115             


Thr Glu  Ala Thr Lys Met Asn  Gly Cys Glu Glu Tyr  Cys Glu Glu 
    2120                 2125                 2130             


Lys Val  Lys Ser Glu Ser Leu  Ile Gln Lys Pro Gln  Glu Lys Lys 
    2135                 2140                 2145             


Thr Asp  Asp Asp Glu Ile Thr  Trp Gly Asn Asp Glu  Leu Pro Ile 
    2150                 2155                 2160             


Glu Arg  Thr Asn His Glu Asp  Ser Asp Lys Asp His  Ser Phe Leu 
    2165                 2170                 2175             


Thr Asn  Asp Glu Leu Ala Val  Leu Pro Val Val Lys  Val Leu Pro 
    2180                 2185                 2190             


Ser Gly  Lys Tyr Thr Gly Ala  Asn Leu Lys Ser Val  Ile Arg Val 
    2195                 2200                 2205             


Leu Arg  Gly Leu Leu Asp Gln  Gly Ile Pro Ser Lys  Glu Leu Glu 
    2210                 2215                 2220             


Asn Leu  Gln Glu Leu Lys Pro  Leu Asp Gln Cys Leu  Ile Gly Gln 
    2225                 2230                 2235             


Thr Lys  Glu Asn Arg Arg Lys  Asn Arg Tyr Lys Asn  Ile Leu Pro 
    2240                 2245                 2250             


Tyr Asp  Ala Thr Arg Val Pro  Leu Gly Asp Glu Gly  Gly Tyr Ile 
    2255                 2260                 2265             


Asn Ala  Ser Phe Ile Lys Ile  Pro Val Gly Lys Glu  Glu Phe Val 
    2270                 2275                 2280             


Tyr Ile  Ala Cys Gln Gly Pro  Leu Pro Thr Thr Val  Gly Asp Phe 
    2285                 2290                 2295             


Trp Gln  Met Ile Trp Glu Gln  Lys Ser Thr Val Ile  Ala Met Met 
    2300                 2305                 2310             


Thr Gln  Glu Val Glu Gly Glu  Lys Ile Lys Cys Gln  Arg Tyr Trp 
    2315                 2320                 2325             


Pro Asn  Ile Leu Gly Lys Thr  Thr Met Val Ser Asn  Arg Leu Arg 
    2330                 2335                 2340             


Leu Ala  Leu Val Arg Met Gln  Gln Leu Lys Gly Phe  Val Val Arg 
    2345                 2350                 2355             


Ala Met  Thr Leu Glu Asp Ile  Gln Thr Arg Glu Val  Arg His Ile 
    2360                 2365                 2370             


Ser His  Leu Asn Phe Thr Ala  Trp Pro Asp His Asp  Thr Pro Ser 
    2375                 2380                 2385             


Gln Pro  Asp Asp Leu Leu Thr  Phe Ile Ser Tyr Met  Arg His Ile 
    2390                 2395                 2400             


His Arg  Ser Gly Pro Ile Ile  Thr His Cys Ser Ala  Gly Ile Gly 
    2405                 2410                 2415             


Arg Ser  Gly Thr Leu Ile Cys  Ile Asp Val Val Leu  Gly Leu Ile 
    2420                 2425                 2430             


Ser Gln  Asp Leu Asp Phe Asp  Ile Ser Asp Leu Val  Arg Cys Met 
    2435                 2440                 2445             


Arg Leu  Gln Arg His Gly Met  Val Gln Thr Glu Asp  Gln Tyr Ile 
    2450                 2455                 2460             


Phe Cys  Tyr Gln Val Ile Leu  Tyr Val Leu Thr Arg  Leu Gln Ala 
    2465                 2470                 2475             


Glu Glu  Glu Gln Lys Gln Gln  Pro Gln Leu Leu Lys  
    2480                 2485                 2490 


<210>  15
<211>  2236
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (282)..(1649)

<400>  15
gctgttgcaa cactgcctca ctcttcccct cccaccttct ctcccctcct ctctgcttta       60

attttctcag aattctctgg actgaggctc cagttctggc ctttggggtt caagatcact      120

gggaccaggc cgtgatctct atgcccgagt ctcaaccctc aactgtcacc ccaaggcact      180

tgggacgtcc tggacagacc gagtcccggg aagccccagc actgccgctg ccacactgcc      240

ctgagcccaa atgggggagt gagaggccat agctgtctgg c atg ggc ctc tcc acc      296
                                              Met Gly Leu Ser Thr         
                                              1               5           

gtg cct gac ctg ctg ctg cca ctg gtg ctc ctg gag ctg ttg gtg gga        344
Val Pro Asp Leu Leu Leu Pro Leu Val Leu Leu Glu Leu Leu Val Gly           
                10                  15                  20                

ata tac ccc tca ggg gtt att gga ctg gtc cct cac cta ggg gac agg        392
Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro His Leu Gly Asp Arg           
            25                  30                  35                    

gag aag aga gat agt gtg tgt ccc caa gga aaa tat atc cac cct caa        440
Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys Tyr Ile His Pro Gln           
        40                  45                  50                        

aat aat tcg att tgc tgt acc aag tgc cac aaa gga acc tac ttg tac        488
Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys Gly Thr Tyr Leu Tyr           
    55                  60                  65                            

aat gac tgt cca ggc ccg ggg cag gat acg gac tgc agg gag tgt gag        536
Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp Cys Arg Glu Cys Glu           
70                  75                  80                  85            

agc ggc tcc ttc acc gct tca gaa aac cac ctc aga cac tgc ctc agc        584
Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu Arg His Cys Leu Ser           
                90                  95                  100               

tgc tcc aaa tgc cga aag gaa atg ggt cag gtg gag atc tct tct tgc        632
Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val Glu Ile Ser Ser Cys           
            105                 110                 115                   

aca gtg gac cgg gac acc gtg tgt ggc tgc agg aag aac cag tac cgg        680
Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg Lys Asn Gln Tyr Arg           
        120                 125                 130                       

cat tat tgg agt gaa aac ctt ttc cag tgc ttc aat tgc agc ctc tgc        728
His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe Asn Cys Ser Leu Cys           
    135                 140                 145                           

ctc aat ggg acc gtg cac ctc tcc tgc cag gag aaa cag aac acc gtg        776
Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu Lys Gln Asn Thr Val           
150                 155                 160                 165           

tgc acc tgc cat gca ggt ttc ttt cta aga gaa aac gag tgt gtc tcc        824
Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu Asn Glu Cys Val Ser           
                170                 175                 180               

tgt agt aac tgt aag aaa agc ctg gag tgc acg aag ttg tgc cta ccc        872
Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr Lys Leu Cys Leu Pro           
            185                 190                 195                   

cag att gag aat gtt aag ggc act gag gac tca ggc acc aca gtg ctg        920
Gln Ile Glu Asn Val Lys Gly Thr Glu Asp Ser Gly Thr Thr Val Leu           
        200                 205                 210                       

ttg ccc ctg gtc att ttc ttt ggt ctt tgc ctt tta tcc ctc ctc ttc        968
Leu Pro Leu Val Ile Phe Phe Gly Leu Cys Leu Leu Ser Leu Leu Phe           
    215                 220                 225                           

att ggt tta atg tat cgc tac caa cgg tgg aag tcc aag ctc tac tcc       1016
Ile Gly Leu Met Tyr Arg Tyr Gln Arg Trp Lys Ser Lys Leu Tyr Ser           
230                 235                 240                 245           

att gtt tgt ggg aaa tcg aca cct gaa aaa gag ggg gag ctt gaa gga       1064
Ile Val Cys Gly Lys Ser Thr Pro Glu Lys Glu Gly Glu Leu Glu Gly           
                250                 255                 260               

act act act aag ccc ctg gcc cca aac cca agc ttc agt ccc act cca       1112
Thr Thr Thr Lys Pro Leu Ala Pro Asn Pro Ser Phe Ser Pro Thr Pro           
            265                 270                 275                   

ggc ttc acc ccc acc ctg ggc ttc agt ccc gtg ccc agt tcc acc ttc       1160
Gly Phe Thr Pro Thr Leu Gly Phe Ser Pro Val Pro Ser Ser Thr Phe           
        280                 285                 290                       

acc tcc agc tcc acc tat acc ccc ggt gac tgt ccc aac ttt gcg gct       1208
Thr Ser Ser Ser Thr Tyr Thr Pro Gly Asp Cys Pro Asn Phe Ala Ala           
    295                 300                 305                           

ccc cgc aga gag gtg gca cca ccc tat cag ggg gct gac ccc atc ctt       1256
Pro Arg Arg Glu Val Ala Pro Pro Tyr Gln Gly Ala Asp Pro Ile Leu           
310                 315                 320                 325           

gcg aca gcc ctc gcc tcc gac ccc atc ccc aac ccc ctt cag aag tgg       1304
Ala Thr Ala Leu Ala Ser Asp Pro Ile Pro Asn Pro Leu Gln Lys Trp           
                330                 335                 340               

gag gac agc gcc cac aag cca cag agc cta gac act gat gac ccc gcg       1352
Glu Asp Ser Ala His Lys Pro Gln Ser Leu Asp Thr Asp Asp Pro Ala           
            345                 350                 355                   

acg ctg tac gcc gtg gtg gag aac gtg ccc ccg ttg cgc tgg aag gaa       1400
Thr Leu Tyr Ala Val Val Glu Asn Val Pro Pro Leu Arg Trp Lys Glu           
        360                 365                 370                       

ttc gtg cgg cgc cta ggg ctg agc gac cac gag atc gat cgg ctg gag       1448
Phe Val Arg Arg Leu Gly Leu Ser Asp His Glu Ile Asp Arg Leu Glu           
    375                 380                 385                           

ctg cag aac ggg cgc tgc ctg cgc gag gcg caa tac agc atg ctg gcg       1496
Leu Gln Asn Gly Arg Cys Leu Arg Glu Ala Gln Tyr Ser Met Leu Ala           
390                 395                 400                 405           

acc tgg agg cgg cgc acg ccg cgg cgc gag gcc acg ctg gag ctg ctg       1544
Thr Trp Arg Arg Arg Thr Pro Arg Arg Glu Ala Thr Leu Glu Leu Leu           
                410                 415                 420               

gga cgc gtg ctc cgc gac atg gac ctg ctg ggc tgc ctg gag gac atc       1592
Gly Arg Val Leu Arg Asp Met Asp Leu Leu Gly Cys Leu Glu Asp Ile           
            425                 430                 435                   

gag gag gcg ctt tgc ggc ccc gcc gcc ctc ccg ccc gcg ccc agt ctt       1640
Glu Glu Ala Leu Cys Gly Pro Ala Ala Leu Pro Pro Ala Pro Ser Leu           
        440                 445                 450                       

ctc aga tga ggctgcgccc ctgcgggcag ctctaaggac cgtcctgcga               1689
Leu Arg                                                                   
    455                                                                   

gatcgccttc caaccccact tttttctgga aaggaggggt cctgcagggg caagcaggag     1749

ctagcagccg cctacttggt gctaacccct cgatgtacat agcttttctc agctgcctgc     1809

gcgccgccga cagtcagcgc tgtgcgcgcg gagagaggtg cgccgtgggc tcaagagcct     1869

gagtgggtgg tttgcgagga tgagggacgc tatgcctcat gcccgttttg ggtgtcctca     1929

ccagcaaggc tgctcggggg cccctggttc gtccctgagc ctttttcaca gtgcataagc     1989

agtttttttt gtttttgttt tgttttgttt tgtttttaaa tcaatcatgt tacactaata     2049

gaaacttggc actcctgtgc cctctgcctg gacaagcaca tagcaagctg aactgtccta     2109

aggcaggggc gagcacggaa caatggggcc ttcagctgga gctgtggact tttgtacata     2169

cactaaaatt ctgaagttaa agctctgctc ttggaaaaaa aaaaaaaaaa aaaaaaaaaa     2229

aaaaaaa                                                               2236


<210>  16
<211>  455
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Leu Ser Thr Val Pro Asp Leu Leu Leu Pro Leu Val Leu Leu 
1               5                   10                  15      


Glu Leu Leu Val Gly Ile Tyr Pro Ser Gly Val Ile Gly Leu Val Pro 
            20                  25                  30          


His Leu Gly Asp Arg Glu Lys Arg Asp Ser Val Cys Pro Gln Gly Lys 
        35                  40                  45              


Tyr Ile His Pro Gln Asn Asn Ser Ile Cys Cys Thr Lys Cys His Lys 
    50                  55                  60                  


Gly Thr Tyr Leu Tyr Asn Asp Cys Pro Gly Pro Gly Gln Asp Thr Asp 
65                  70                  75                  80  


Cys Arg Glu Cys Glu Ser Gly Ser Phe Thr Ala Ser Glu Asn His Leu 
                85                  90                  95      


Arg His Cys Leu Ser Cys Ser Lys Cys Arg Lys Glu Met Gly Gln Val 
            100                 105                 110         


Glu Ile Ser Ser Cys Thr Val Asp Arg Asp Thr Val Cys Gly Cys Arg 
        115                 120                 125             


Lys Asn Gln Tyr Arg His Tyr Trp Ser Glu Asn Leu Phe Gln Cys Phe 
    130                 135                 140                 


Asn Cys Ser Leu Cys Leu Asn Gly Thr Val His Leu Ser Cys Gln Glu 
145                 150                 155                 160 


Lys Gln Asn Thr Val Cys Thr Cys His Ala Gly Phe Phe Leu Arg Glu 
                165                 170                 175     


Asn Glu Cys Val Ser Cys Ser Asn Cys Lys Lys Ser Leu Glu Cys Thr 
            180                 185                 190         


Lys Leu Cys Leu Pro Gln Ile Glu Asn Val Lys Gly Thr Glu Asp Ser 
        195                 200                 205             


Gly Thr Thr Val Leu Leu Pro Leu Val Ile Phe Phe Gly Leu Cys Leu 
    210                 215                 220                 


Leu Ser Leu Leu Phe Ile Gly Leu Met Tyr Arg Tyr Gln Arg Trp Lys 
225                 230                 235                 240 


Ser Lys Leu Tyr Ser Ile Val Cys Gly Lys Ser Thr Pro Glu Lys Glu 
                245                 250                 255     


Gly Glu Leu Glu Gly Thr Thr Thr Lys Pro Leu Ala Pro Asn Pro Ser 
            260                 265                 270         


Phe Ser Pro Thr Pro Gly Phe Thr Pro Thr Leu Gly Phe Ser Pro Val 
        275                 280                 285             


Pro Ser Ser Thr Phe Thr Ser Ser Ser Thr Tyr Thr Pro Gly Asp Cys 
    290                 295                 300                 


Pro Asn Phe Ala Ala Pro Arg Arg Glu Val Ala Pro Pro Tyr Gln Gly 
305                 310                 315                 320 


Ala Asp Pro Ile Leu Ala Thr Ala Leu Ala Ser Asp Pro Ile Pro Asn 
                325                 330                 335     


Pro Leu Gln Lys Trp Glu Asp Ser Ala His Lys Pro Gln Ser Leu Asp 
            340                 345                 350         


Thr Asp Asp Pro Ala Thr Leu Tyr Ala Val Val Glu Asn Val Pro Pro 
        355                 360                 365             


Leu Arg Trp Lys Glu Phe Val Arg Arg Leu Gly Leu Ser Asp His Glu 
    370                 375                 380                 


Ile Asp Arg Leu Glu Leu Gln Asn Gly Arg Cys Leu Arg Glu Ala Gln 
385                 390                 395                 400 


Tyr Ser Met Leu Ala Thr Trp Arg Arg Arg Thr Pro Arg Arg Glu Ala 
                405                 410                 415     


Thr Leu Glu Leu Leu Gly Arg Val Leu Arg Asp Met Asp Leu Leu Gly 
            420                 425                 430         


Cys Leu Glu Asp Ile Glu Glu Ala Leu Cys Gly Pro Ala Ala Leu Pro 
        435                 440                 445             


Pro Ala Pro Ser Leu Leu Arg 
    450                 455 


<210>  17
<211>  3682
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (90)..(1475)

<400>  17
gcgagcgcag cggagcctgg agagaaggcg ctgggctgcg agggcgcgag ggcgcgaggg       60

cagggggcaa ccggaccccg cccgcaccc atg gcg ccc gtc gcc gtc tgg gcc        113
                                Met Ala Pro Val Ala Val Trp Ala           
                                1               5                         

gcg ctg gcc gtc gga ctg gag ctc tgg gct gcg gcg cac gcc ttg ccc        161
Ala Leu Ala Val Gly Leu Glu Leu Trp Ala Ala Ala His Ala Leu Pro           
    10                  15                  20                            

gcc cag gtg gca ttt aca ccc tac gcc ccg gag ccc ggg agc aca tgc        209
Ala Gln Val Ala Phe Thr Pro Tyr Ala Pro Glu Pro Gly Ser Thr Cys           
25                  30                  35                  40            

cgg ctc aga gaa tac tat gac cag aca gct cag atg tgc tgc agc aaa        257
Arg Leu Arg Glu Tyr Tyr Asp Gln Thr Ala Gln Met Cys Cys Ser Lys           
                45                  50                  55                

tgc tcg ccg ggc caa cat gca aaa gtc ttc tgt acc aag acc tcg gac        305
Cys Ser Pro Gly Gln His Ala Lys Val Phe Cys Thr Lys Thr Ser Asp           
            60                  65                  70                    

acc gtg tgt gac tcc tgt gag gac agc aca tac acc cag ctc tgg aac        353
Thr Val Cys Asp Ser Cys Glu Asp Ser Thr Tyr Thr Gln Leu Trp Asn           
        75                  80                  85                        

tgg gtt ccc gag tgc ttg agc tgt ggc tcc cgc tgt agc tct gac cag        401
Trp Val Pro Glu Cys Leu Ser Cys Gly Ser Arg Cys Ser Ser Asp Gln           
    90                  95                  100                           

gtg gaa act caa gcc tgc act cgg gaa cag aac cgc atc tgc acc tgc        449
Val Glu Thr Gln Ala Cys Thr Arg Glu Gln Asn Arg Ile Cys Thr Cys           
105                 110                 115                 120           

agg ccc ggc tgg tac tgc gcg ctg agc aag cag gag ggg tgc cgg ctg        497
Arg Pro Gly Trp Tyr Cys Ala Leu Ser Lys Gln Glu Gly Cys Arg Leu           
                125                 130                 135               

tgc gcg ccg ctg cgc aag tgc cgc ccg ggc ttc ggc gtg gcc aga cca        545
Cys Ala Pro Leu Arg Lys Cys Arg Pro Gly Phe Gly Val Ala Arg Pro           
            140                 145                 150                   

gga act gaa aca tca gac gtg gtg tgc aag ccc tgt gcc ccg ggg acg        593
Gly Thr Glu Thr Ser Asp Val Val Cys Lys Pro Cys Ala Pro Gly Thr           
        155                 160                 165                       

ttc tcc aac acg act tca tcc acg gat att tgc agg ccc cac cag atc        641
Phe Ser Asn Thr Thr Ser Ser Thr Asp Ile Cys Arg Pro His Gln Ile           
    170                 175                 180                           

tgt aac gtg gtg gcc atc cct ggg aat gca agc atg gat gca gtc tgc        689
Cys Asn Val Val Ala Ile Pro Gly Asn Ala Ser Met Asp Ala Val Cys           
185                 190                 195                 200           

acg tcc acg tcc ccc acc cgg agt atg gcc cca ggg gca gta cac tta        737
Thr Ser Thr Ser Pro Thr Arg Ser Met Ala Pro Gly Ala Val His Leu           
                205                 210                 215               

ccc cag cca gtg tcc aca cga tcc caa cac acg cag cca act cca gaa        785
Pro Gln Pro Val Ser Thr Arg Ser Gln His Thr Gln Pro Thr Pro Glu           
            220                 225                 230                   

ccc agc act gct cca agc acc tcc ttc ctg ctc cca atg ggc ccc agc        833
Pro Ser Thr Ala Pro Ser Thr Ser Phe Leu Leu Pro Met Gly Pro Ser           
        235                 240                 245                       

ccc cca gct gaa ggg agc act ggc gac ttc gct ctt cca gtt gga ctg        881
Pro Pro Ala Glu Gly Ser Thr Gly Asp Phe Ala Leu Pro Val Gly Leu           
    250                 255                 260                           

att gtg ggt gtg aca gcc ttg ggt cta cta ata ata gga gtg gtg aac        929
Ile Val Gly Val Thr Ala Leu Gly Leu Leu Ile Ile Gly Val Val Asn           
265                 270                 275                 280           

tgt gtc atc atg acc cag gtg aaa aag aag ccc ttg tgc ctg cag aga        977
Cys Val Ile Met Thr Gln Val Lys Lys Lys Pro Leu Cys Leu Gln Arg           
                285                 290                 295               

gaa gcc aag gtg cct cac ttg cct gcc gat aag gcc cgg ggt aca cag       1025
Glu Ala Lys Val Pro His Leu Pro Ala Asp Lys Ala Arg Gly Thr Gln           
            300                 305                 310                   

ggc ccc gag cag cag cac ctg ctg atc aca gcg ccg agc tcc agc agc       1073
Gly Pro Glu Gln Gln His Leu Leu Ile Thr Ala Pro Ser Ser Ser Ser           
        315                 320                 325                       

agc tcc ctg gag agc tcg gcc agt gcg ttg gac aga agg gcg ccc act       1121
Ser Ser Leu Glu Ser Ser Ala Ser Ala Leu Asp Arg Arg Ala Pro Thr           
    330                 335                 340                           

cgg aac cag cca cag gca cca ggc gtg gag gcc agt ggg gcc ggg gag       1169
Arg Asn Gln Pro Gln Ala Pro Gly Val Glu Ala Ser Gly Ala Gly Glu           
345                 350                 355                 360           

gcc cgg gcc agc acc ggg agc tca gat tct tcc cct ggt ggc cat ggg       1217
Ala Arg Ala Ser Thr Gly Ser Ser Asp Ser Ser Pro Gly Gly His Gly           
                365                 370                 375               

acc cag gtc aat gtc acc tgc atc gtg aac gtc tgt agc agc tct gac       1265
Thr Gln Val Asn Val Thr Cys Ile Val Asn Val Cys Ser Ser Ser Asp           
            380                 385                 390                   

cac agc tca cag tgc tcc tcc caa gcc agc tcc aca atg gga gac aca       1313
His Ser Ser Gln Cys Ser Ser Gln Ala Ser Ser Thr Met Gly Asp Thr           
        395                 400                 405                       

gat tcc agc ccc tcg gag tcc ccg aag gac gag cag gtc ccc ttc tcc       1361
Asp Ser Ser Pro Ser Glu Ser Pro Lys Asp Glu Gln Val Pro Phe Ser           
    410                 415                 420                           

aag gag gaa tgt gcc ttt cgg tca cag ctg gag acg cca gag acc ctg       1409
Lys Glu Glu Cys Ala Phe Arg Ser Gln Leu Glu Thr Pro Glu Thr Leu           
425                 430                 435                 440           

ctg ggg agc acc gaa gag aag ccc ctg ccc ctt gga gtg cct gat gct       1457
Leu Gly Ser Thr Glu Glu Lys Pro Leu Pro Leu Gly Val Pro Asp Ala           
                445                 450                 455               

ggg atg aag ccc agt taa ccaggccggt gtgggctgtg tcgtagccaa              1505
Gly Met Lys Pro Ser                                                       
            460                                                           

ggtgggctga gccctggcag gatgaccctg cgaaggggcc ctggtccttc caggccccca     1565

ccactaggac tctgaggctc tttctgggcc aagttcctct agtgccctcc acagccgcag     1625

cctccctctg acctgcaggc caagagcaga ggcagcgagt tgtggaaagc ctctgctgcc     1685

atggcgtgtc cctctcggaa ggctggctgg gcatggacgt tcggggcatg ctggggcaag     1745

tccctgactc tctgtgacct gccccgccca gctgcacctg ccagcctggc ttctggagcc     1805

cttgggtttt ttgtttgttt gtttgtttgt ttgtttgttt ctccccctgg gctctgcccc     1865

agctctggct tccagaaaac cccagcatcc ttttctgcag aggggctttc tggagaggag     1925

ggatgctgcc tgagtcaccc atgaagacag gacagtgctt cagcctgagg ctgagactgc     1985

gggatggtcc tggggctctg tgcagggagg aggtggcagc cctgtaggga acggggtcct     2045

tcaagttagc tcaggaggct tggaaagcat cacctcaggc caggtgcagt ggctcacgcc     2105

tatgatccca gcactttggg aggctgaggc gggtggatca cctgaggtta ggagttcgag     2165

accagcctgg ccaacatggt aaaaccccat ctctactaaa aatacagaaa ttagccgggc     2225

gtggtggcgg gcacctatag tcccagctac tcagaagcct gaggctggga aatcgtttga     2285

acccgggaag cggaggttgc agggagccga gatcacgcca ctgcactcca gcctgggcga     2345

cagagcgaga gtctgtctca aaagaaaaaa aaaagcaccg cctccaaatg ccaacttgtc     2405

cttttgtacc atggtgtgaa agtcagatgc ccagagggcc caggcaggcc accatattca     2465

gtgctgtggc ctgggcaaga taacgcactt ctaactagaa atctgccaat tttttaaaaa     2525

agtaagtacc actcaggcca acaagccaac gacaaagcca aactctgcca gccacatcca     2585

accccccacc tgccatttgc accctccgcc ttcactccgg tgtgcctgca gccccgcgcc     2645

tccttccttg ctgtcctagg ccacaccatc tcctttcagg gaatttcagg aactagagat     2705

gactgagtcc tcgtagccat ctctctactc ctacctcagc ctagaccctc ctcctccccc     2765

agaggggtgg gttcctcttc cccactcccc accttcaatt cctgggcccc aaacgggctg     2825

ccctgccact ttggtacatg gccagtgtga tcccaagtgc cagtcttgtg tctgcgtctg     2885

tgttgcgtgt cgtgggtgtg tgtagccaag gtcggtaagt tgaatggcct gccttgaagc     2945

cactgaagct gggattcctc cccattagag tcagccttcc ccctcccagg gccagggccc     3005

tgcagagggg aaaccagtgt agccttgccc ggattctggg aggaagcagg ttgaggggct     3065

cctggaaagg ctcagtctca ggagcatggg gataaaggag aaggcatgaa attgtctagc     3125

agagcagggg cagggtgata aattgttgat aaattccact ggacttgagc ttggcagctg     3185

aactattgga gggtgggaga gcccagccat taccatggag acaagaaggg ttttccaccc     3245

tggaatcaag atgtcagact ggctggctgc agtgacgtgc acctgtactc aggaggctga     3305

ggggaggatc actggagccc aggagtttga ggctgcagcg agctatgatc gcgccactac     3365

actccagcct gagcaacaga gtgagaccct gtctcttaaa gaaaaaaaaa gtcagactgc     3425

tgggactggc caggtttctg cccacattgg acccacatga ggacatgatg gagcgcacct     3485

gccccctggt ggacagtcct gggagaacct caggcttcct tggcatcaca gggcagagcc     3545

gggaagcgat gaatttggag actctgtggg gccttggttc ccttgtgtgt gtgtgttgat     3605

cccaagacaa tgaaagtttg cactgtatgc tggacggcat tcctgcttat caataaacct     3665

gtttgtttta aaaaaaa                                                    3682


<210>  18
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Ala Pro Val Ala Val Trp Ala Ala Leu Ala Val Gly Leu Glu Leu 
1               5                   10                  15      


Trp Ala Ala Ala His Ala Leu Pro Ala Gln Val Ala Phe Thr Pro Tyr 
            20                  25                  30          


Ala Pro Glu Pro Gly Ser Thr Cys Arg Leu Arg Glu Tyr Tyr Asp Gln 
        35                  40                  45              


Thr Ala Gln Met Cys Cys Ser Lys Cys Ser Pro Gly Gln His Ala Lys 
    50                  55                  60                  


Val Phe Cys Thr Lys Thr Ser Asp Thr Val Cys Asp Ser Cys Glu Asp 
65                  70                  75                  80  


Ser Thr Tyr Thr Gln Leu Trp Asn Trp Val Pro Glu Cys Leu Ser Cys 
                85                  90                  95      


Gly Ser Arg Cys Ser Ser Asp Gln Val Glu Thr Gln Ala Cys Thr Arg 
            100                 105                 110         


Glu Gln Asn Arg Ile Cys Thr Cys Arg Pro Gly Trp Tyr Cys Ala Leu 
        115                 120                 125             


Ser Lys Gln Glu Gly Cys Arg Leu Cys Ala Pro Leu Arg Lys Cys Arg 
    130                 135                 140                 


Pro Gly Phe Gly Val Ala Arg Pro Gly Thr Glu Thr Ser Asp Val Val 
145                 150                 155                 160 


Cys Lys Pro Cys Ala Pro Gly Thr Phe Ser Asn Thr Thr Ser Ser Thr 
                165                 170                 175     


Asp Ile Cys Arg Pro His Gln Ile Cys Asn Val Val Ala Ile Pro Gly 
            180                 185                 190         


Asn Ala Ser Met Asp Ala Val Cys Thr Ser Thr Ser Pro Thr Arg Ser 
        195                 200                 205             


Met Ala Pro Gly Ala Val His Leu Pro Gln Pro Val Ser Thr Arg Ser 
    210                 215                 220                 


Gln His Thr Gln Pro Thr Pro Glu Pro Ser Thr Ala Pro Ser Thr Ser 
225                 230                 235                 240 


Phe Leu Leu Pro Met Gly Pro Ser Pro Pro Ala Glu Gly Ser Thr Gly 
                245                 250                 255     


Asp Phe Ala Leu Pro Val Gly Leu Ile Val Gly Val Thr Ala Leu Gly 
            260                 265                 270         


Leu Leu Ile Ile Gly Val Val Asn Cys Val Ile Met Thr Gln Val Lys 
        275                 280                 285             


Lys Lys Pro Leu Cys Leu Gln Arg Glu Ala Lys Val Pro His Leu Pro 
    290                 295                 300                 


Ala Asp Lys Ala Arg Gly Thr Gln Gly Pro Glu Gln Gln His Leu Leu 
305                 310                 315                 320 


Ile Thr Ala Pro Ser Ser Ser Ser Ser Ser Leu Glu Ser Ser Ala Ser 
                325                 330                 335     


Ala Leu Asp Arg Arg Ala Pro Thr Arg Asn Gln Pro Gln Ala Pro Gly 
            340                 345                 350         


Val Glu Ala Ser Gly Ala Gly Glu Ala Arg Ala Ser Thr Gly Ser Ser 
        355                 360                 365             


Asp Ser Ser Pro Gly Gly His Gly Thr Gln Val Asn Val Thr Cys Ile 
    370                 375                 380                 


Val Asn Val Cys Ser Ser Ser Asp His Ser Ser Gln Cys Ser Ser Gln 
385                 390                 395                 400 


Ala Ser Ser Thr Met Gly Asp Thr Asp Ser Ser Pro Ser Glu Ser Pro 
                405                 410                 415     


Lys Asp Glu Gln Val Pro Phe Ser Lys Glu Glu Cys Ala Phe Arg Ser 
            420                 425                 430         


Gln Leu Glu Thr Pro Glu Thr Leu Leu Gly Ser Thr Glu Glu Lys Pro 
        435                 440                 445             


Leu Pro Leu Gly Val Pro Asp Ala Gly Met Lys Pro Ser 
    450                 455                 460     


<210>  19
<211>  2136
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (169)..(1476)

<400>  19
gccctggagg cccggcctgg ccgctcccgg ccctggggtg cacatcggcc ctgagtcccg       60

tcccaggctc tgggctcggg cagccgccgc caccgctgcc caggacgtcg ggcctcctgc      120

cttcctccca ggcccccacg ttgctggccg cctggccgag tggccgcc atg ctc ctg       177
                                                     Met Leu Leu          
                                                     1                    

cct tgg gcc acc tct gcc ccc ggc ctg gcc tgg ggg cct ctg gtg ctg        225
Pro Trp Ala Thr Ser Ala Pro Gly Leu Ala Trp Gly Pro Leu Val Leu           
    5                   10                  15                            

ggc ctc ttc ggg ctc ctg gca gca tcg cag ccc cag gcg gtg cct cca        273
Gly Leu Phe Gly Leu Leu Ala Ala Ser Gln Pro Gln Ala Val Pro Pro           
20                  25                  30                  35            

tat gcg tcg gag aac cag acc tgc agg gac cag gaa aag gaa tac tat        321
Tyr Ala Ser Glu Asn Gln Thr Cys Arg Asp Gln Glu Lys Glu Tyr Tyr           
                40                  45                  50                

gag ccc cag cac cgc atc tgc tgc tcc cgc tgc ccg cca ggc acc tat        369
Glu Pro Gln His Arg Ile Cys Cys Ser Arg Cys Pro Pro Gly Thr Tyr           
            55                  60                  65                    

gtc tca gct aaa tgt agc cgc atc cgg gac aca gtt tgt gcc aca tgt        417
Val Ser Ala Lys Cys Ser Arg Ile Arg Asp Thr Val Cys Ala Thr Cys           
        70                  75                  80                        

gcc gag aat tcc tac aac gag cac tgg aac tac ctg acc atc tgc cag        465
Ala Glu Asn Ser Tyr Asn Glu His Trp Asn Tyr Leu Thr Ile Cys Gln           
    85                  90                  95                            

ctg tgc cgc ccc tgt gac cca gtg atg ggc ctc gag gag att gcc ccc        513
Leu Cys Arg Pro Cys Asp Pro Val Met Gly Leu Glu Glu Ile Ala Pro           
100                 105                 110                 115           

tgc aca agc aaa cgg aag acc cag tgc cgc tgc cag ccg gga atg ttc        561
Cys Thr Ser Lys Arg Lys Thr Gln Cys Arg Cys Gln Pro Gly Met Phe           
                120                 125                 130               

tgt gct gcc tgg gcc ctc gag tgt aca cac tgc gag cta ctt tct gac        609
Cys Ala Ala Trp Ala Leu Glu Cys Thr His Cys Glu Leu Leu Ser Asp           
            135                 140                 145                   

tgc ccg cct ggc act gaa gcc gag ctc aaa gat gaa gtt ggg aag ggt        657
Cys Pro Pro Gly Thr Glu Ala Glu Leu Lys Asp Glu Val Gly Lys Gly           
        150                 155                 160                       

aac aac cac tgc gtc ccc tgc aag gca ggg cac ttc cag aat acc tcc        705
Asn Asn His Cys Val Pro Cys Lys Ala Gly His Phe Gln Asn Thr Ser           
    165                 170                 175                           

tcc ccc agc gcc cgc tgc cag ccc cac acc agg tgt gag aac caa ggt        753
Ser Pro Ser Ala Arg Cys Gln Pro His Thr Arg Cys Glu Asn Gln Gly           
180                 185                 190                 195           

ctg gtg gag gca gct cca ggc act gcc cag tcc gac aca acc tgc aaa        801
Leu Val Glu Ala Ala Pro Gly Thr Ala Gln Ser Asp Thr Thr Cys Lys           
                200                 205                 210               

aat cca tta gag cca ctg ccc cca gag atg tca gga acc atg ctg atg        849
Asn Pro Leu Glu Pro Leu Pro Pro Glu Met Ser Gly Thr Met Leu Met           
            215                 220                 225                   

ctg gcc gtt ctg ctg cca ctg gcc ttc ttt ctg ctc ctt gcc acc gtc        897
Leu Ala Val Leu Leu Pro Leu Ala Phe Phe Leu Leu Leu Ala Thr Val           
        230                 235                 240                       

ttc tcc tgc atc tgg aag agc cac cct tct ctc tgc agg aaa ctg gga        945
Phe Ser Cys Ile Trp Lys Ser His Pro Ser Leu Cys Arg Lys Leu Gly           
    245                 250                 255                           

tcg ctg ctc aag agg cgt ccg cag gga gag gga ccc aat cct gta gct        993
Ser Leu Leu Lys Arg Arg Pro Gln Gly Glu Gly Pro Asn Pro Val Ala           
260                 265                 270                 275           

gga agc tgg gag cct ccg aag gcc cat cca tac ttc cct gac ttg gta       1041
Gly Ser Trp Glu Pro Pro Lys Ala His Pro Tyr Phe Pro Asp Leu Val           
                280                 285                 290               

cag cca ctg cta ccc att tct gga gat gtt tcc cca gta tcc act ggg       1089
Gln Pro Leu Leu Pro Ile Ser Gly Asp Val Ser Pro Val Ser Thr Gly           
            295                 300                 305                   

ctc ccc gca gcc cca gtt ttg gag gca ggg gtg ccg caa cag cag agt       1137
Leu Pro Ala Ala Pro Val Leu Glu Ala Gly Val Pro Gln Gln Gln Ser           
        310                 315                 320                       

cct ctg gac ctg acc agg gag ccg cag ttg gaa ccc ggg gag cag agc       1185
Pro Leu Asp Leu Thr Arg Glu Pro Gln Leu Glu Pro Gly Glu Gln Ser           
    325                 330                 335                           

cag gtg gcc cac ggt acc aat ggc att cat gtc acc ggc ggg tct atg       1233
Gln Val Ala His Gly Thr Asn Gly Ile His Val Thr Gly Gly Ser Met           
340                 345                 350                 355           

act atc act ggc aac atc tac atc tac aat gga cca gta ctg ggg gga       1281
Thr Ile Thr Gly Asn Ile Tyr Ile Tyr Asn Gly Pro Val Leu Gly Gly           
                360                 365                 370               

cca ccg ggt cct gga gac ctc cca gct acc ccc gaa cct cca tac ccc       1329
Pro Pro Gly Pro Gly Asp Leu Pro Ala Thr Pro Glu Pro Pro Tyr Pro           
            375                 380                 385                   

att ccc gaa gag ggg gac cct ggc cct ccc ggg ctc tct aca ccc cac       1377
Ile Pro Glu Glu Gly Asp Pro Gly Pro Pro Gly Leu Ser Thr Pro His           
        390                 395                 400                       

cag gaa gat ggc aag gct tgg cac cta gcg gag aca gag cac tgt ggt       1425
Gln Glu Asp Gly Lys Ala Trp His Leu Ala Glu Thr Glu His Cys Gly           
    405                 410                 415                           

gcc aca ccc tct aac agg ggc cca agg aac caa ttt atc acc cat gac       1473
Ala Thr Pro Ser Asn Arg Gly Pro Arg Asn Gln Phe Ile Thr His Asp           
420                 425                 430                 435           

tga cggagtctga gaaaaggcag aagaaggggg gcacaagggc actttctccc            1526

ttgaggctgc cctgcccacg tgggattcac aggggcctga gtagggcccg gggaagcaga     1586

gccctaaggg attaaggctc agacacctct gagagcaggt gggcactggc tgggtacggt     1646

gccctccaca ggactctccc tactgcctga gcaaacctga ggcctcccgg cagacccacc     1706

caccccctgg ggctgctcag cctcaggcac ggacagggca catgatacca actgctgccc     1766

actacggcac gccgcaccgg agcacggcac cgagggagcc gccacacggt cacctgcaag     1826

gacgtcacgg gcccctctaa aggattcgtg gtgctcatcc ccaagcttca gagacccttt     1886

ggggttccac acttcacgtg gactgaggta gaccctgcat gaagatgaaa ttatagggag     1946

gacgctcctt ccctcccctc ctagaggaga ggaaagggag tcattaacaa ctagggggtt     2006

gggtaggatt cctaggtatg gggaagagtt ttggaagggg aggaaaatgg caagtgtatt     2066

tatattgtaa ccacatgcaa ataaaaagaa tgggacctaa actcgtgccg ctcgtgccga     2126

attcctgcag                                                            2136


<210>  20
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Leu Leu Pro Trp Ala Thr Ser Ala Pro Gly Leu Ala Trp Gly Pro 
1               5                   10                  15      


Leu Val Leu Gly Leu Phe Gly Leu Leu Ala Ala Ser Gln Pro Gln Ala 
            20                  25                  30          


Val Pro Pro Tyr Ala Ser Glu Asn Gln Thr Cys Arg Asp Gln Glu Lys 
        35                  40                  45              


Glu Tyr Tyr Glu Pro Gln His Arg Ile Cys Cys Ser Arg Cys Pro Pro 
    50                  55                  60                  


Gly Thr Tyr Val Ser Ala Lys Cys Ser Arg Ile Arg Asp Thr Val Cys 
65                  70                  75                  80  


Ala Thr Cys Ala Glu Asn Ser Tyr Asn Glu His Trp Asn Tyr Leu Thr 
                85                  90                  95      


Ile Cys Gln Leu Cys Arg Pro Cys Asp Pro Val Met Gly Leu Glu Glu 
            100                 105                 110         


Ile Ala Pro Cys Thr Ser Lys Arg Lys Thr Gln Cys Arg Cys Gln Pro 
        115                 120                 125             


Gly Met Phe Cys Ala Ala Trp Ala Leu Glu Cys Thr His Cys Glu Leu 
    130                 135                 140                 


Leu Ser Asp Cys Pro Pro Gly Thr Glu Ala Glu Leu Lys Asp Glu Val 
145                 150                 155                 160 


Gly Lys Gly Asn Asn His Cys Val Pro Cys Lys Ala Gly His Phe Gln 
                165                 170                 175     


Asn Thr Ser Ser Pro Ser Ala Arg Cys Gln Pro His Thr Arg Cys Glu 
            180                 185                 190         


Asn Gln Gly Leu Val Glu Ala Ala Pro Gly Thr Ala Gln Ser Asp Thr 
        195                 200                 205             


Thr Cys Lys Asn Pro Leu Glu Pro Leu Pro Pro Glu Met Ser Gly Thr 
    210                 215                 220                 


Met Leu Met Leu Ala Val Leu Leu Pro Leu Ala Phe Phe Leu Leu Leu 
225                 230                 235                 240 


Ala Thr Val Phe Ser Cys Ile Trp Lys Ser His Pro Ser Leu Cys Arg 
                245                 250                 255     


Lys Leu Gly Ser Leu Leu Lys Arg Arg Pro Gln Gly Glu Gly Pro Asn 
            260                 265                 270         


Pro Val Ala Gly Ser Trp Glu Pro Pro Lys Ala His Pro Tyr Phe Pro 
        275                 280                 285             


Asp Leu Val Gln Pro Leu Leu Pro Ile Ser Gly Asp Val Ser Pro Val 
    290                 295                 300                 


Ser Thr Gly Leu Pro Ala Ala Pro Val Leu Glu Ala Gly Val Pro Gln 
305                 310                 315                 320 


Gln Gln Ser Pro Leu Asp Leu Thr Arg Glu Pro Gln Leu Glu Pro Gly 
                325                 330                 335     


Glu Gln Ser Gln Val Ala His Gly Thr Asn Gly Ile His Val Thr Gly 
            340                 345                 350         


Gly Ser Met Thr Ile Thr Gly Asn Ile Tyr Ile Tyr Asn Gly Pro Val 
        355                 360                 365             


Leu Gly Gly Pro Pro Gly Pro Gly Asp Leu Pro Ala Thr Pro Glu Pro 
    370                 375                 380                 


Pro Tyr Pro Ile Pro Glu Glu Gly Asp Pro Gly Pro Pro Gly Leu Ser 
385                 390                 395                 400 


Thr Pro His Gln Glu Asp Gly Lys Ala Trp His Leu Ala Glu Thr Glu 
                405                 410                 415     


His Cys Gly Ala Thr Pro Ser Asn Arg Gly Pro Arg Asn Gln Phe Ile 
            420                 425                 430         


Thr His Asp 
        435 


<210>  21
<211>  4093
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (468)..(3377)

<400>  21
gtgagagagt gagcgagaca gaaagagaga gaagtgcacc agcgagccgg ggcaggaaga       60

ggaggtttcg ccaccggagc ggcccggcga cgcgctgaca gcttcccctg cccttcccgt      120

cggtcgggcc gccagccgcc gcagccctcg gcctgcacgc agccaccggc cccgctcccg      180

gagcccagcg ccgccgaggc cgcagccgcc cggccagtaa ggcggcgccg ccgcccggcc      240

accgcgcgcc ctgcgcttcc ctccgcccgc gctgcggcca tggcgcggcg ctgactggcc      300

tggcccggcc ccgccgcgct cccgctcgcc ccgacccgca ctcgggcccg cccgggctcc      360

ggcctgccgc cgcctcttcc ttctccagcc ggcaggcccg cgccgcttag gagggagagc      420

ccacccgcgc caggaggccg aacgcggact cgccacccgg cttcaga atg gca gaa        476
                                                    Met Ala Glu           
                                                    1                     

gat gat cca tat ttg gga agg cct gaa caa atg ttt cat ttg gat cct        524
Asp Asp Pro Tyr Leu Gly Arg Pro Glu Gln Met Phe His Leu Asp Pro           
    5                   10                  15                            

tct ttg act cat aca ata ttt aat cca gaa gta ttt caa cca cag atg        572
Ser Leu Thr His Thr Ile Phe Asn Pro Glu Val Phe Gln Pro Gln Met           
20                  25                  30                  35            

gca ctg cca aca gca gat ggc cca tac ctt caa ata tta gag caa cct        620
Ala Leu Pro Thr Ala Asp Gly Pro Tyr Leu Gln Ile Leu Glu Gln Pro           
                40                  45                  50                

aaa cag aga gga ttt cgt ttc cgt tat gta tgt gaa ggc cca tcc cat        668
Lys Gln Arg Gly Phe Arg Phe Arg Tyr Val Cys Glu Gly Pro Ser His           
            55                  60                  65                    

ggt gga cta cct ggt gcc tct agt gaa aag aac aag aag tct tac cct        716
Gly Gly Leu Pro Gly Ala Ser Ser Glu Lys Asn Lys Lys Ser Tyr Pro           
        70                  75                  80                        

cag gtc aaa atc tgc aac tat gtg gga cca gca aag gtt att gtt cag        764
Gln Val Lys Ile Cys Asn Tyr Val Gly Pro Ala Lys Val Ile Val Gln           
    85                  90                  95                            

ttg gtc aca aat gga aaa aat atc cac ctg cat gcc cac agc ctg gtg        812
Leu Val Thr Asn Gly Lys Asn Ile His Leu His Ala His Ser Leu Val           
100                 105                 110                 115           

gga aaa cac tgt gag gat ggg atc tgc act gta act gct gga ccc aag        860
Gly Lys His Cys Glu Asp Gly Ile Cys Thr Val Thr Ala Gly Pro Lys           
                120                 125                 130               

gac atg gtg gtc ggc ttc gca aac ctg ggt ata ctt cat gtg aca aag        908
Asp Met Val Val Gly Phe Ala Asn Leu Gly Ile Leu His Val Thr Lys           
            135                 140                 145                   

aaa aaa gta ttt gaa aca ctg gaa gca cga atg aca gag gcg tgt ata        956
Lys Lys Val Phe Glu Thr Leu Glu Ala Arg Met Thr Glu Ala Cys Ile           
        150                 155                 160                       

agg ggc tat aat cct gga ctc ttg gtg cac cct gac ctt gcc tat ttg       1004
Arg Gly Tyr Asn Pro Gly Leu Leu Val His Pro Asp Leu Ala Tyr Leu           
    165                 170                 175                           

caa gca gaa ggt gga ggg gac cgg cag ctg gga gat cgg gaa aaa gag       1052
Gln Ala Glu Gly Gly Gly Asp Arg Gln Leu Gly Asp Arg Glu Lys Glu           
180                 185                 190                 195           

cta atc cgc caa gca gct ctg cag cag acc aag gag atg gac ctc agc       1100
Leu Ile Arg Gln Ala Ala Leu Gln Gln Thr Lys Glu Met Asp Leu Ser           
                200                 205                 210               

gtg gtg cgg ctc atg ttt aca gct ttt ctt ccg gat agc act ggc agc       1148
Val Val Arg Leu Met Phe Thr Ala Phe Leu Pro Asp Ser Thr Gly Ser           
            215                 220                 225                   

ttc aca agg cgc ctg gaa ccc gtg gta tca gac gcc atc tat gac agt       1196
Phe Thr Arg Arg Leu Glu Pro Val Val Ser Asp Ala Ile Tyr Asp Ser           
        230                 235                 240                       

aaa gcc ccc aat gca tcc aac ttg aaa att gta aga atg gac agg aca       1244
Lys Ala Pro Asn Ala Ser Asn Leu Lys Ile Val Arg Met Asp Arg Thr           
    245                 250                 255                           

gct gga tgt gtg act gga ggg gag gaa att tat ctt ctt tgt gac aaa       1292
Ala Gly Cys Val Thr Gly Gly Glu Glu Ile Tyr Leu Leu Cys Asp Lys           
260                 265                 270                 275           

gtt cag aaa gat gac atc cag att cga ttt tat gaa gag gaa gaa aat       1340
Val Gln Lys Asp Asp Ile Gln Ile Arg Phe Tyr Glu Glu Glu Glu Asn           
                280                 285                 290               

ggt gga gtc tgg gaa gga ttt gga gat ttt tcc ccc aca gat gtt cat       1388
Gly Gly Val Trp Glu Gly Phe Gly Asp Phe Ser Pro Thr Asp Val His           
            295                 300                 305                   

aga caa ttt gcc att gtc ttc aaa act cca aag tat aaa gat att aat       1436
Arg Gln Phe Ala Ile Val Phe Lys Thr Pro Lys Tyr Lys Asp Ile Asn           
        310                 315                 320                       

att aca aaa cca gcc tct gtg ttt gtc cag ctt cgg agg aaa tct gac       1484
Ile Thr Lys Pro Ala Ser Val Phe Val Gln Leu Arg Arg Lys Ser Asp           
    325                 330                 335                           

ttg gaa act agt gaa cca aaa cct ttc ctc tac tat cct gaa atc aaa       1532
Leu Glu Thr Ser Glu Pro Lys Pro Phe Leu Tyr Tyr Pro Glu Ile Lys           
340                 345                 350                 355           

gat aaa gaa gaa gtg cag agg aaa cgt cag aag ctc atg ccc aat ttt       1580
Asp Lys Glu Glu Val Gln Arg Lys Arg Gln Lys Leu Met Pro Asn Phe           
                360                 365                 370               

tcg gat agt ttc ggc ggt ggt agt ggt gct gga gct gga ggc gga ggc       1628
Ser Asp Ser Phe Gly Gly Gly Ser Gly Ala Gly Ala Gly Gly Gly Gly           
            375                 380                 385                   

atg ttt ggt agt ggc ggt gga gga ggg ggc act gga agt aca ggt cca       1676
Met Phe Gly Ser Gly Gly Gly Gly Gly Gly Thr Gly Ser Thr Gly Pro           
        390                 395                 400                       

ggg tat agc ttc cca cac tat gga ttt cct act tat ggt ggg att act       1724
Gly Tyr Ser Phe Pro His Tyr Gly Phe Pro Thr Tyr Gly Gly Ile Thr           
    405                 410                 415                           

ttc cat cct gga act act aaa tct aat gct ggg atg aag cat gga acc       1772
Phe His Pro Gly Thr Thr Lys Ser Asn Ala Gly Met Lys His Gly Thr           
420                 425                 430                 435           

atg gac act gaa tct aaa aag gac cct gaa ggt tgt gac aaa agt gat       1820
Met Asp Thr Glu Ser Lys Lys Asp Pro Glu Gly Cys Asp Lys Ser Asp           
                440                 445                 450               

gac aaa aac act gta aac ctc ttt ggg aaa gtt att gaa acc aca gag       1868
Asp Lys Asn Thr Val Asn Leu Phe Gly Lys Val Ile Glu Thr Thr Glu           
            455                 460                 465                   

caa gat cag gag ccc agc gag gcc acc gtt ggg aat ggt gag gtc act       1916
Gln Asp Gln Glu Pro Ser Glu Ala Thr Val Gly Asn Gly Glu Val Thr           
        470                 475                 480                       

cta acg tat gca aca gga aca aaa gaa gag agt gct gga gtt cag gat       1964
Leu Thr Tyr Ala Thr Gly Thr Lys Glu Glu Ser Ala Gly Val Gln Asp           
    485                 490                 495                           

aac ctc ttt cta gag aag gct atg cag ctt gca aag agg cat gcc aat       2012
Asn Leu Phe Leu Glu Lys Ala Met Gln Leu Ala Lys Arg His Ala Asn           
500                 505                 510                 515           

gcc ctt ttc gac tac gcg gtg aca gga gac gtg aag atg ctg ctg gcc       2060
Ala Leu Phe Asp Tyr Ala Val Thr Gly Asp Val Lys Met Leu Leu Ala           
                520                 525                 530               

gtc cag cgc cat ctc act gct gtg cag gat gag aat ggg gac agt gtc       2108
Val Gln Arg His Leu Thr Ala Val Gln Asp Glu Asn Gly Asp Ser Val           
            535                 540                 545                   

tta cac tta gca atc atc cac ctt cat tct caa ctt gtg agg gat cta       2156
Leu His Leu Ala Ile Ile His Leu His Ser Gln Leu Val Arg Asp Leu           
        550                 555                 560                       

cta gaa gtc aca tct ggt ttg att tct gat gac att atc aac atg aga       2204
Leu Glu Val Thr Ser Gly Leu Ile Ser Asp Asp Ile Ile Asn Met Arg           
    565                 570                 575                           

aat gat ctg tac cag acg ccc ttg cac ttg gca gtg atc act aag cag       2252
Asn Asp Leu Tyr Gln Thr Pro Leu His Leu Ala Val Ile Thr Lys Gln           
580                 585                 590                 595           

gaa gat gtg gtg gag gat ttg ctg agg gct ggg gcc gac ctg agc ctt       2300
Glu Asp Val Val Glu Asp Leu Leu Arg Ala Gly Ala Asp Leu Ser Leu           
                600                 605                 610               

ctg gac cgc ttg ggt aac tct gtt ttg cac cta gct gcc aaa gaa gga       2348
Leu Asp Arg Leu Gly Asn Ser Val Leu His Leu Ala Ala Lys Glu Gly           
            615                 620                 625                   

cat gat aaa gtt ctc agt atc tta ctc aag cac aaa aag gca gca cta       2396
His Asp Lys Val Leu Ser Ile Leu Leu Lys His Lys Lys Ala Ala Leu           
        630                 635                 640                       

ctt ctt gac cac ccc aac ggg gac ggt ctg aat gcc att cat cta gcc       2444
Leu Leu Asp His Pro Asn Gly Asp Gly Leu Asn Ala Ile His Leu Ala           
    645                 650                 655                           

atg atg agc aat agc ctg cca tgt ttg ctg ctg ctg gtg gcc gct ggg       2492
Met Met Ser Asn Ser Leu Pro Cys Leu Leu Leu Leu Val Ala Ala Gly           
660                 665                 670                 675           

gct gac gtc aat gct cag gag cag aag tcc ggg cgc aca gca ctg cac       2540
Ala Asp Val Asn Ala Gln Glu Gln Lys Ser Gly Arg Thr Ala Leu His           
                680                 685                 690               

ctg gct gtg gag cac gac aac atc tca ttg gca ggc tgc ctg ctc ctg       2588
Leu Ala Val Glu His Asp Asn Ile Ser Leu Ala Gly Cys Leu Leu Leu           
            695                 700                 705                   

gag ggt gat gcc cat gtg gac agt act acc tac gat gga acc aca ccc       2636
Glu Gly Asp Ala His Val Asp Ser Thr Thr Tyr Asp Gly Thr Thr Pro           
        710                 715                 720                       

ctg cat ata gca gct ggg aga ggg tcc acc agg ctg gca gct ctt ctc       2684
Leu His Ile Ala Ala Gly Arg Gly Ser Thr Arg Leu Ala Ala Leu Leu           
    725                 730                 735                           

aaa gca gca gga gca gat ccc ctg gtg gag aac ttt gag cct ctc tat       2732
Lys Ala Ala Gly Ala Asp Pro Leu Val Glu Asn Phe Glu Pro Leu Tyr           
740                 745                 750                 755           

gac ctg gat gac tct tgg gaa aat gca gga gag gat gaa gga gtt gtg       2780
Asp Leu Asp Asp Ser Trp Glu Asn Ala Gly Glu Asp Glu Gly Val Val           
                760                 765                 770               

cct gga acc acg cct cta gat atg gcc acc agc tgg cag gta ttt gac       2828
Pro Gly Thr Thr Pro Leu Asp Met Ala Thr Ser Trp Gln Val Phe Asp           
            775                 780                 785                   

ata tta aat ggg aaa cca tat gag cca gag ttt aca tct gat gat tta       2876
Ile Leu Asn Gly Lys Pro Tyr Glu Pro Glu Phe Thr Ser Asp Asp Leu           
        790                 795                 800                       

cta gca caa gga gac atg aaa cag ctg gct gaa gat gtg aag ctg cag       2924
Leu Ala Gln Gly Asp Met Lys Gln Leu Ala Glu Asp Val Lys Leu Gln           
    805                 810                 815                           

ctg tat aag tta cta gaa att cct gat cca gac aaa aac tgg gct act       2972
Leu Tyr Lys Leu Leu Glu Ile Pro Asp Pro Asp Lys Asn Trp Ala Thr           
820                 825                 830                 835           

ctg gcg cag aaa tta ggt ctg ggg ata ctt aat aat gcc ttc cgg ctg       3020
Leu Ala Gln Lys Leu Gly Leu Gly Ile Leu Asn Asn Ala Phe Arg Leu           
                840                 845                 850               

agt cct gct cct tcc aaa aca ctt atg gac aac tat gag gtc tct ggg       3068
Ser Pro Ala Pro Ser Lys Thr Leu Met Asp Asn Tyr Glu Val Ser Gly           
            855                 860                 865                   

ggt aca gtc aga gag ctg gtg gag gcc ctg aga caa atg ggc tac acc       3116
Gly Thr Val Arg Glu Leu Val Glu Ala Leu Arg Gln Met Gly Tyr Thr           
        870                 875                 880                       

gaa gca att gaa gtg atc cag gca gcc tcc agc cca gtg aag acc acc       3164
Glu Ala Ile Glu Val Ile Gln Ala Ala Ser Ser Pro Val Lys Thr Thr           
    885                 890                 895                           

tct cag gcc cac tcg ctg cct ctc tcg cct gcc tcc aca agg cag caa       3212
Ser Gln Ala His Ser Leu Pro Leu Ser Pro Ala Ser Thr Arg Gln Gln           
900                 905                 910                 915           

ata gac gag ctc cga gac agt gac agt gtc tgc gac agc ggc gtg gag       3260
Ile Asp Glu Leu Arg Asp Ser Asp Ser Val Cys Asp Ser Gly Val Glu           
                920                 925                 930               

aca tcc ttc cgc aaa ctc agc ttt acc gag tct ctg acc agt ggt gcc       3308
Thr Ser Phe Arg Lys Leu Ser Phe Thr Glu Ser Leu Thr Ser Gly Ala           
            935                 940                 945                   

tca ctg cta act ctc aac aaa atg ccc cat gat tat ggg cag gaa gga       3356
Ser Leu Leu Thr Leu Asn Lys Met Pro His Asp Tyr Gly Gln Glu Gly           
        950                 955                 960                       

cct cta gaa ggc aaa att tag cctgctgaca atttcccaca ccgtgtaaac          3407
Pro Leu Glu Gly Lys Ile                                                   
    965                                                                   

caaagcccta aaattccact gcgttgtcca caagacagaa gctgaagtgc atccaaaggt     3467

gctcagagag ccggcccgcc tgaatcattc tcgatttaac tcgagacctt ttcaacttgg     3527

cttcctttct tggttcataa atgaatttta gtttggttca cttacagata gtatctagca     3587

atcacaacac tggctgagcg gatgcatctg gggatgaggt tgcttactaa gctttgccag     3647

ctgctgctgg atcacagctg ctttctgttg tcattgctgt tgtccctctg ctacgttcct     3707

attgtcatta aaggtatcac ggtcgccacc tggcattcct tctgaccaca gcatcatttt     3767

gcattcaaat taagggttaa gaaaagagat attttaaaat gagagtcact tgatgtgcca     3827

ttttaaaaaa aaaggcatat tgctttttct aatgtggtta tttctctgat ttgcaaaaaa     3887

aaaaaaaaaa aaaatacttg tcaatattta aacatggtta caatcattgc tgaaaatggt     3947

attttccccc ttttctgcat tttgctattg taaatatgtt ttttagatca aatactttaa     4007

aggaaaaaat gttggattta taaatgctat tttttatttt acttttataa taaaaggaaa     4067

agcaaattga tgacctcaaa aaaaaa                                          4093


<210>  22
<211>  969
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Ala Glu Asp Asp Pro Tyr Leu Gly Arg Pro Glu Gln Met Phe His 
1               5                   10                  15      


Leu Asp Pro Ser Leu Thr His Thr Ile Phe Asn Pro Glu Val Phe Gln 
            20                  25                  30          


Pro Gln Met Ala Leu Pro Thr Ala Asp Gly Pro Tyr Leu Gln Ile Leu 
        35                  40                  45              


Glu Gln Pro Lys Gln Arg Gly Phe Arg Phe Arg Tyr Val Cys Glu Gly 
    50                  55                  60                  


Pro Ser His Gly Gly Leu Pro Gly Ala Ser Ser Glu Lys Asn Lys Lys 
65                  70                  75                  80  


Ser Tyr Pro Gln Val Lys Ile Cys Asn Tyr Val Gly Pro Ala Lys Val 
                85                  90                  95      


Ile Val Gln Leu Val Thr Asn Gly Lys Asn Ile His Leu His Ala His 
            100                 105                 110         


Ser Leu Val Gly Lys His Cys Glu Asp Gly Ile Cys Thr Val Thr Ala 
        115                 120                 125             


Gly Pro Lys Asp Met Val Val Gly Phe Ala Asn Leu Gly Ile Leu His 
    130                 135                 140                 


Val Thr Lys Lys Lys Val Phe Glu Thr Leu Glu Ala Arg Met Thr Glu 
145                 150                 155                 160 


Ala Cys Ile Arg Gly Tyr Asn Pro Gly Leu Leu Val His Pro Asp Leu 
                165                 170                 175     


Ala Tyr Leu Gln Ala Glu Gly Gly Gly Asp Arg Gln Leu Gly Asp Arg 
            180                 185                 190         


Glu Lys Glu Leu Ile Arg Gln Ala Ala Leu Gln Gln Thr Lys Glu Met 
        195                 200                 205             


Asp Leu Ser Val Val Arg Leu Met Phe Thr Ala Phe Leu Pro Asp Ser 
    210                 215                 220                 


Thr Gly Ser Phe Thr Arg Arg Leu Glu Pro Val Val Ser Asp Ala Ile 
225                 230                 235                 240 


Tyr Asp Ser Lys Ala Pro Asn Ala Ser Asn Leu Lys Ile Val Arg Met 
                245                 250                 255     


Asp Arg Thr Ala Gly Cys Val Thr Gly Gly Glu Glu Ile Tyr Leu Leu 
            260                 265                 270         


Cys Asp Lys Val Gln Lys Asp Asp Ile Gln Ile Arg Phe Tyr Glu Glu 
        275                 280                 285             


Glu Glu Asn Gly Gly Val Trp Glu Gly Phe Gly Asp Phe Ser Pro Thr 
    290                 295                 300                 


Asp Val His Arg Gln Phe Ala Ile Val Phe Lys Thr Pro Lys Tyr Lys 
305                 310                 315                 320 


Asp Ile Asn Ile Thr Lys Pro Ala Ser Val Phe Val Gln Leu Arg Arg 
                325                 330                 335     


Lys Ser Asp Leu Glu Thr Ser Glu Pro Lys Pro Phe Leu Tyr Tyr Pro 
            340                 345                 350         


Glu Ile Lys Asp Lys Glu Glu Val Gln Arg Lys Arg Gln Lys Leu Met 
        355                 360                 365             


Pro Asn Phe Ser Asp Ser Phe Gly Gly Gly Ser Gly Ala Gly Ala Gly 
    370                 375                 380                 


Gly Gly Gly Met Phe Gly Ser Gly Gly Gly Gly Gly Gly Thr Gly Ser 
385                 390                 395                 400 


Thr Gly Pro Gly Tyr Ser Phe Pro His Tyr Gly Phe Pro Thr Tyr Gly 
                405                 410                 415     


Gly Ile Thr Phe His Pro Gly Thr Thr Lys Ser Asn Ala Gly Met Lys 
            420                 425                 430         


His Gly Thr Met Asp Thr Glu Ser Lys Lys Asp Pro Glu Gly Cys Asp 
        435                 440                 445             


Lys Ser Asp Asp Lys Asn Thr Val Asn Leu Phe Gly Lys Val Ile Glu 
    450                 455                 460                 


Thr Thr Glu Gln Asp Gln Glu Pro Ser Glu Ala Thr Val Gly Asn Gly 
465                 470                 475                 480 


Glu Val Thr Leu Thr Tyr Ala Thr Gly Thr Lys Glu Glu Ser Ala Gly 
                485                 490                 495     


Val Gln Asp Asn Leu Phe Leu Glu Lys Ala Met Gln Leu Ala Lys Arg 
            500                 505                 510         


His Ala Asn Ala Leu Phe Asp Tyr Ala Val Thr Gly Asp Val Lys Met 
        515                 520                 525             


Leu Leu Ala Val Gln Arg His Leu Thr Ala Val Gln Asp Glu Asn Gly 
    530                 535                 540                 


Asp Ser Val Leu His Leu Ala Ile Ile His Leu His Ser Gln Leu Val 
545                 550                 555                 560 


Arg Asp Leu Leu Glu Val Thr Ser Gly Leu Ile Ser Asp Asp Ile Ile 
                565                 570                 575     


Asn Met Arg Asn Asp Leu Tyr Gln Thr Pro Leu His Leu Ala Val Ile 
            580                 585                 590         


Thr Lys Gln Glu Asp Val Val Glu Asp Leu Leu Arg Ala Gly Ala Asp 
        595                 600                 605             


Leu Ser Leu Leu Asp Arg Leu Gly Asn Ser Val Leu His Leu Ala Ala 
    610                 615                 620                 


Lys Glu Gly His Asp Lys Val Leu Ser Ile Leu Leu Lys His Lys Lys 
625                 630                 635                 640 


Ala Ala Leu Leu Leu Asp His Pro Asn Gly Asp Gly Leu Asn Ala Ile 
                645                 650                 655     


His Leu Ala Met Met Ser Asn Ser Leu Pro Cys Leu Leu Leu Leu Val 
            660                 665                 670         


Ala Ala Gly Ala Asp Val Asn Ala Gln Glu Gln Lys Ser Gly Arg Thr 
        675                 680                 685             


Ala Leu His Leu Ala Val Glu His Asp Asn Ile Ser Leu Ala Gly Cys 
    690                 695                 700                 


Leu Leu Leu Glu Gly Asp Ala His Val Asp Ser Thr Thr Tyr Asp Gly 
705                 710                 715                 720 


Thr Thr Pro Leu His Ile Ala Ala Gly Arg Gly Ser Thr Arg Leu Ala 
                725                 730                 735     


Ala Leu Leu Lys Ala Ala Gly Ala Asp Pro Leu Val Glu Asn Phe Glu 
            740                 745                 750         


Pro Leu Tyr Asp Leu Asp Asp Ser Trp Glu Asn Ala Gly Glu Asp Glu 
        755                 760                 765             


Gly Val Val Pro Gly Thr Thr Pro Leu Asp Met Ala Thr Ser Trp Gln 
    770                 775                 780                 


Val Phe Asp Ile Leu Asn Gly Lys Pro Tyr Glu Pro Glu Phe Thr Ser 
785                 790                 795                 800 


Asp Asp Leu Leu Ala Gln Gly Asp Met Lys Gln Leu Ala Glu Asp Val 
                805                 810                 815     


Lys Leu Gln Leu Tyr Lys Leu Leu Glu Ile Pro Asp Pro Asp Lys Asn 
            820                 825                 830         


Trp Ala Thr Leu Ala Gln Lys Leu Gly Leu Gly Ile Leu Asn Asn Ala 
        835                 840                 845             


Phe Arg Leu Ser Pro Ala Pro Ser Lys Thr Leu Met Asp Asn Tyr Glu 
    850                 855                 860                 


Val Ser Gly Gly Thr Val Arg Glu Leu Val Glu Ala Leu Arg Gln Met 
865                 870                 875                 880 


Gly Tyr Thr Glu Ala Ile Glu Val Ile Gln Ala Ala Ser Ser Pro Val 
                885                 890                 895     


Lys Thr Thr Ser Gln Ala His Ser Leu Pro Leu Ser Pro Ala Ser Thr 
            900                 905                 910         


Arg Gln Gln Ile Asp Glu Leu Arg Asp Ser Asp Ser Val Cys Asp Ser 
        915                 920                 925             


Gly Val Glu Thr Ser Phe Arg Lys Leu Ser Phe Thr Glu Ser Leu Thr 
    930                 935                 940                 


Ser Gly Ala Ser Leu Leu Thr Leu Asn Lys Met Pro His Asp Tyr Gly 
945                 950                 955                 960 


Gln Glu Gly Pro Leu Glu Gly Lys Ile 
                965                 


<210>  23
<211>  4978
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (241)..(2553)

<400>  23
ggtttccgga gctgcggcgg cgcagactgg gagggggagc cgggggttcc gacgtcgcag       60

ccgagggaac aagccccaac cggatcctgg acaggcaccc cggcttggcg ctgtctctcc      120

ccctcggctc ggagaggccc ttcggcctga gggagcctcg ccgcccgtcc ccggcacacg      180

cgcagccccg gcctctcggc ctctgccgga gaaacagttg ggacccctga ttttagcagg      240

atg gcc caa tgg aat cag cta cag cag ctt gac aca cgg tac ctg gag        288
Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu           
1               5                   10                  15                

cag ctc cat cag ctc tac agt gac agc ttc cca atg gag ctg cgg cag        336
Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln           
            20                  25                  30                    

ttt ctg gcc cct tgg att gag agt caa gat tgg gca tat gcg gcc agc        384
Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser           
        35                  40                  45                        

aaa gaa tca cat gcc act ttg gtg ttt cat aat ctc ctg gga gag att        432
Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile           
    50                  55                  60                            

gac cag cag tat agc cgc ttc ctg caa gag tcg aat gtt ctc tat cag        480
Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln           
65                  70                  75                  80            

cac aat cta cga aga atc aag cag ttt ctt cag agc agg tat ctt gag        528
His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu           
                85                  90                  95                

aag cca atg gag att gcc cgg att gtg gcc cgg tgc ctg tgg gaa gaa        576
Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu           
            100                 105                 110                   

tca cgc ctt cta cag act gca gcc act gcg gcc cag caa ggg ggc cag        624
Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln           
        115                 120                 125                       

gcc aac cac ccc aca gca gcc gtg gtg acg gag aag cag cag atg ctg        672
Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu           
    130                 135                 140                           

gag cag cac ctt cag gat gtc cgg aag aga gtg cag gat cta gaa cag        720
Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln           
145                 150                 155                 160           

aaa atg aaa gtg gta gag aat ctc cag gat gac ttt gat ttc aac tat        768
Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr           
                165                 170                 175               

aaa acc ctc aag agt caa gga gac atg caa gat ctg aat gga aac aac        816
Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn           
            180                 185                 190                   

cag tca gtg acc agg cag aag atg cag cag ctg gaa cag atg ctc act        864
Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr           
        195                 200                 205                       

gcg ctg gac cag atg cgg aga agc atc gtg agt gag ctg gcg ggg ctt        912
Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu           
    210                 215                 220                           

ttg tca gcg atg gag tac gtg cag aaa act ctc acg gac gag gag ctg        960
Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu           
225                 230                 235                 240           

gct gac tgg aag agg cgg caa cag att gcc tgc att gga ggc ccg ccc       1008
Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro           
                245                 250                 255               

aac atc tgc cta gat cgg cta gaa aac tgg ata acg tca tta gca gaa       1056
Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu           
            260                 265                 270                   

tct caa ctt cag acc cgt caa caa att aag aaa ctg gag gag ttg cag       1104
Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln           
        275                 280                 285                       

caa aaa gtt tcc tac aaa ggg gac ccc att gta cag cac cgg ccg atg       1152
Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met           
    290                 295                 300                           

ctg gag gag aga atc gtg gag ctg ttt aga aac tta atg aaa agt gcc       1200
Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala           
305                 310                 315                 320           

ttt gtg gtg gag cgg cag ccc tgc atg ccc atg cat cct gac cgg ccc       1248
Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro           
                325                 330                 335               

ctc gtc atc aag acc ggc gtc cag ttc act act aaa gtc agg ttg ctg       1296
Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu           
            340                 345                 350                   

gtc aaa ttc cct gag ttg aat tat cag ctt aaa att aaa gtg tgc att       1344
Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile           
        355                 360                 365                       

gac aaa gac tct ggg gac gtt gca gct ctc aga gga tcc cgg aaa ttt       1392
Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe           
    370                 375                 380                           

aac att ctg ggc aca aac aca aaa gtg atg aac atg gaa gaa tcc aac       1440
Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn           
385                 390                 395                 400           

aac ggc agc ctc tct gca gaa ttc aaa cac ttg acc ctg agg gag cag       1488
Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln           
                405                 410                 415               

aga tgt ggg aat ggg ggc cga gcc aat tgt gat gct tcc ctg att gtg       1536
Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val           
            420                 425                 430                   

act gag gag ctg cac ctg atc acc ttt gag acc gag gtg tat cac caa       1584
Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln           
        435                 440                 445                       

ggc ctc aag att gac cta gag acc cac tcc ttg cca gtt gtg gtg atc       1632
Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile           
    450                 455                 460                           

tcc aac atc tgt cag atg cca aat gcc tgg gcg tcc atc ctg tgg tac       1680
Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr           
465                 470                 475                 480           

aac atg ctg acc aac aat ccc aag aat gta aac ttt ttt acc aag ccc       1728
Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro           
                485                 490                 495               

cca att gga acc tgg gat caa gtg gcc gag gtc ctg agc tgg cag ttc       1776
Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe           
            500                 505                 510                   

tcc tcc acc acc aag cga gga ctg agc atc gag cag ctg act aca ctg       1824
Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu           
        515                 520                 525                       

gca gag aaa ctc ttg gga cct ggt gtg aat tat tca ggg tgt cag atc       1872
Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile           
    530                 535                 540                           

aca tgg gct aaa ttt tgc aaa gaa aac atg gct ggc aag ggc ttc tcc       1920
Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser           
545                 550                 555                 560           

ttc tgg gtc tgg ctg gac aat atc att gac ctt gtg aaa aag tac atc       1968
Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile           
                565                 570                 575               

ctg gcc ctt tgg aac gaa ggg tac atc atg ggc ttt atc agt aag gag       2016
Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu           
            580                 585                 590                   

cgg gag cgg gcc atc ttg agc act aag cct cca ggc acc ttc ctg cta       2064
Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu           
        595                 600                 605                       

aga ttc agt gaa agc agc aaa gaa gga ggc gtc act ttc act tgg gtg       2112
Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val           
    610                 615                 620                           

gag aag gac atc agc ggt aag acc cag atc cag tcc gtg gaa cca tac       2160
Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr           
625                 630                 635                 640           

aca aag cag cag ctg aac aac atg tca ttt gct gaa atc atc atg ggc       2208
Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly           
                645                 650                 655               

tat aag atc atg gat gct acc aat atc ctg gtg tct cca ctg gtc tat       2256
Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr           
            660                 665                 670                   

ctc tat cct gac att ccc aag gag gag gca ttc gga aag tat tgt cgg       2304
Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg           
        675                 680                 685                       

cca gag agc cag gag cat cct gaa gct gac cca ggt agc gct gcc cca       2352
Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ser Ala Ala Pro           
    690                 695                 700                           

tac ctg aag acc aag ttt atc tgt gtg aca cca acg acc tgc agc aat       2400
Tyr Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn           
705                 710                 715                 720           

acc att gac ctg ccg atg tcc ccc cgc act tta gat tca ttg atg cag       2448
Thr Ile Asp Leu Pro Met Ser Pro Arg Thr Leu Asp Ser Leu Met Gln           
                725                 730                 735               

ttt gga aat aat ggt gaa ggt gct gaa ccc tca gca gga ggg cag ttt       2496
Phe Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe           
            740                 745                 750                   

gag tcc ctc acc ttt gac atg gag ttg acc tcg gag tgc gct acc tcc       2544
Glu Ser Leu Thr Phe Asp Met Glu Leu Thr Ser Glu Cys Ala Thr Ser           
        755                 760                 765                       

ccc atg tga ggagctgaga acggaagctg cagaaagata cgactgaggc               2593
Pro Met                                                                   
    770                                                                   

gcctacctgc attctgccac ccctcacaca gccaaacccc agatcatctg aaactactaa     2653

ctttgtggtt ccagattttt tttaatctcc tacttctgct atctttgagc aatctgggca     2713

cttttaaaaa tagagaaatg agtgaatgtg ggtgatctgc ttttatctaa atgcaaataa     2773

ggatgtgttc tctgagaccc atgatcaggg gatgtggcgg ggggtggcta gagggagaaa     2833

aaggaaatgt cttgtgttgt tttgttcccc tgccctcctt tctcagcagc tttttgttat     2893

tgttgttgtt gttcttagac aagtgcctcc tggtgcctgc ggcatccttc tgcctgtttc     2953

tgtaagcaaa tgccacaggc cacctatagc tacatactcc tggcattgca ctttttaacc     3013

ttgctgacat ccaaatagaa gataggacta tctaagccct aggtttcttt ttaaattaag     3073

aaataataac aattaaaggg caaaaaacac tgtatcagca tagcctttct gtatttaaga     3133

aacttaagca gccgggcatg gtggctcacg cctgtaatcc cagcactttg ggaggccgag     3193

gcggatcata aggtcaggag atcaagacca tcctggctaa cacggtgaaa ccccgtctct     3253

actaaaagta caaaaaatta gctgggtgtg gtggtgggcg cctgtagtcc cagctactcg     3313

ggaggctgag gcaggagaat cgcttgaacc tgagaggcgg aggttgcagt gagccaaaat     3373

tgcaccactg cacactgcac tccatcctgg gcgacagtct gagactctgt ctcaaaaaaa     3433

aaaaaaaaaa aaagaaactt cagttaacag cctccttggt gctttaagca ttcagcttcc     3493

ttcaggctgg taatttatat aatccctgaa acgggcttca ggtcaaaccc ttaagacatc     3553

tgaagctgca acctggcctt tggtgttgaa ataggaaggt ttaaggagaa tctaagcatt     3613

ttagactttt ttttataaat agacttattt tcctttgtaa tgtattggcc ttttagtgag     3673

taaggctggg cagagggtgc ttacaacctt gactcccttt ctccctggac ttgatctgct     3733

gtttcagagg ctaggttgtt tctgtgggtg ccttatcagg gctgggatac ttctgattct     3793

ggcttccttc ctgccccacc ctcccgaccc cagtccccct gatcctgcta gaggcatgtc     3853

tccttgcgtg tctaaaggtc cctcatcctg tttgttttag gaatcctggt ctcaggacct     3913

catggaagaa gagggggaga gagttacagg ttggacatga tgcacactat ggggccccag     3973

cgacgtgtct ggttgagctc agggaatatg gttcttagcc agtttcttgg tgatatccag     4033

tggcacttgt aatggcgtct tcattcagtt catgcagggc aaaggcttac tgataaactt     4093

gagtctgccc tcgtatgagg gtgtatacct ggcctccctc tgaggctggt gactcctccc     4153

tgctggggcc ccacaggtga ggcagaacag ctagagggcc tccccgcctg cccgccttgg     4213

ctggctagct cgcctctcct gtgcgtatgg gaacacctag cacgtgctgg atgggctgcc     4273

tctgactcag aggcatggcc ggatttggca actcaaaacc accttgcctc agctgatcag     4333

agtttctgtg gaattctgtt tgttaaatca aattagctgg tctctgaatt aagggggaga     4393

cgaccttctc taagatgaac agggttcgcc ccagtcctcc tgcctggaga cagttgatgt     4453

gtcatgcaga gctcttactt ctccagcaac actcttcagt acataataag cttaactgat     4513

aaacagaata tttagaaagg tgagacttgg gcttaccatt gggtttaaat catagggacc     4573

tagggcgagg gttcagggct tctctggagc agatattgtc aagttcatgg ccttaggtag     4633

catgtatctg gtcttaactc tgattgtagc aaaagttctg agaggagctg agccctgttg     4693

tggcccatta aagaacaggg tcctcaggcc ctgcccgctt cctgtccact gccccctccc     4753

catccccagc ccagccgagg gaatcccgtg ggttgcttac ctacctataa ggtggtttat     4813

aagctgctgt cctggccact gcattcaaat tccaatgtgt acttcatagt gtaaaaattt     4873

atattattgt gaggtttttt gtcttttttt tttttttttt tttttggtat attgctgtat     4933

ctactttaac ttccagaaat aaacgttata taggaaccgt aaaaa                     4978


<210>  24
<211>  770
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Gln Trp Asn Gln Leu Gln Gln Leu Asp Thr Arg Tyr Leu Glu 
1               5                   10                  15      


Gln Leu His Gln Leu Tyr Ser Asp Ser Phe Pro Met Glu Leu Arg Gln 
            20                  25                  30          


Phe Leu Ala Pro Trp Ile Glu Ser Gln Asp Trp Ala Tyr Ala Ala Ser 
        35                  40                  45              


Lys Glu Ser His Ala Thr Leu Val Phe His Asn Leu Leu Gly Glu Ile 
    50                  55                  60                  


Asp Gln Gln Tyr Ser Arg Phe Leu Gln Glu Ser Asn Val Leu Tyr Gln 
65                  70                  75                  80  


His Asn Leu Arg Arg Ile Lys Gln Phe Leu Gln Ser Arg Tyr Leu Glu 
                85                  90                  95      


Lys Pro Met Glu Ile Ala Arg Ile Val Ala Arg Cys Leu Trp Glu Glu 
            100                 105                 110         


Ser Arg Leu Leu Gln Thr Ala Ala Thr Ala Ala Gln Gln Gly Gly Gln 
        115                 120                 125             


Ala Asn His Pro Thr Ala Ala Val Val Thr Glu Lys Gln Gln Met Leu 
    130                 135                 140                 


Glu Gln His Leu Gln Asp Val Arg Lys Arg Val Gln Asp Leu Glu Gln 
145                 150                 155                 160 


Lys Met Lys Val Val Glu Asn Leu Gln Asp Asp Phe Asp Phe Asn Tyr 
                165                 170                 175     


Lys Thr Leu Lys Ser Gln Gly Asp Met Gln Asp Leu Asn Gly Asn Asn 
            180                 185                 190         


Gln Ser Val Thr Arg Gln Lys Met Gln Gln Leu Glu Gln Met Leu Thr 
        195                 200                 205             


Ala Leu Asp Gln Met Arg Arg Ser Ile Val Ser Glu Leu Ala Gly Leu 
    210                 215                 220                 


Leu Ser Ala Met Glu Tyr Val Gln Lys Thr Leu Thr Asp Glu Glu Leu 
225                 230                 235                 240 


Ala Asp Trp Lys Arg Arg Gln Gln Ile Ala Cys Ile Gly Gly Pro Pro 
                245                 250                 255     


Asn Ile Cys Leu Asp Arg Leu Glu Asn Trp Ile Thr Ser Leu Ala Glu 
            260                 265                 270         


Ser Gln Leu Gln Thr Arg Gln Gln Ile Lys Lys Leu Glu Glu Leu Gln 
        275                 280                 285             


Gln Lys Val Ser Tyr Lys Gly Asp Pro Ile Val Gln His Arg Pro Met 
    290                 295                 300                 


Leu Glu Glu Arg Ile Val Glu Leu Phe Arg Asn Leu Met Lys Ser Ala 
305                 310                 315                 320 


Phe Val Val Glu Arg Gln Pro Cys Met Pro Met His Pro Asp Arg Pro 
                325                 330                 335     


Leu Val Ile Lys Thr Gly Val Gln Phe Thr Thr Lys Val Arg Leu Leu 
            340                 345                 350         


Val Lys Phe Pro Glu Leu Asn Tyr Gln Leu Lys Ile Lys Val Cys Ile 
        355                 360                 365             


Asp Lys Asp Ser Gly Asp Val Ala Ala Leu Arg Gly Ser Arg Lys Phe 
    370                 375                 380                 


Asn Ile Leu Gly Thr Asn Thr Lys Val Met Asn Met Glu Glu Ser Asn 
385                 390                 395                 400 


Asn Gly Ser Leu Ser Ala Glu Phe Lys His Leu Thr Leu Arg Glu Gln 
                405                 410                 415     


Arg Cys Gly Asn Gly Gly Arg Ala Asn Cys Asp Ala Ser Leu Ile Val 
            420                 425                 430         


Thr Glu Glu Leu His Leu Ile Thr Phe Glu Thr Glu Val Tyr His Gln 
        435                 440                 445             


Gly Leu Lys Ile Asp Leu Glu Thr His Ser Leu Pro Val Val Val Ile 
    450                 455                 460                 


Ser Asn Ile Cys Gln Met Pro Asn Ala Trp Ala Ser Ile Leu Trp Tyr 
465                 470                 475                 480 


Asn Met Leu Thr Asn Asn Pro Lys Asn Val Asn Phe Phe Thr Lys Pro 
                485                 490                 495     


Pro Ile Gly Thr Trp Asp Gln Val Ala Glu Val Leu Ser Trp Gln Phe 
            500                 505                 510         


Ser Ser Thr Thr Lys Arg Gly Leu Ser Ile Glu Gln Leu Thr Thr Leu 
        515                 520                 525             


Ala Glu Lys Leu Leu Gly Pro Gly Val Asn Tyr Ser Gly Cys Gln Ile 
    530                 535                 540                 


Thr Trp Ala Lys Phe Cys Lys Glu Asn Met Ala Gly Lys Gly Phe Ser 
545                 550                 555                 560 


Phe Trp Val Trp Leu Asp Asn Ile Ile Asp Leu Val Lys Lys Tyr Ile 
                565                 570                 575     


Leu Ala Leu Trp Asn Glu Gly Tyr Ile Met Gly Phe Ile Ser Lys Glu 
            580                 585                 590         


Arg Glu Arg Ala Ile Leu Ser Thr Lys Pro Pro Gly Thr Phe Leu Leu 
        595                 600                 605             


Arg Phe Ser Glu Ser Ser Lys Glu Gly Gly Val Thr Phe Thr Trp Val 
    610                 615                 620                 


Glu Lys Asp Ile Ser Gly Lys Thr Gln Ile Gln Ser Val Glu Pro Tyr 
625                 630                 635                 640 


Thr Lys Gln Gln Leu Asn Asn Met Ser Phe Ala Glu Ile Ile Met Gly 
                645                 650                 655     


Tyr Lys Ile Met Asp Ala Thr Asn Ile Leu Val Ser Pro Leu Val Tyr 
            660                 665                 670         


Leu Tyr Pro Asp Ile Pro Lys Glu Glu Ala Phe Gly Lys Tyr Cys Arg 
        675                 680                 685             


Pro Glu Ser Gln Glu His Pro Glu Ala Asp Pro Gly Ser Ala Ala Pro 
    690                 695                 700                 


Tyr Leu Lys Thr Lys Phe Ile Cys Val Thr Pro Thr Thr Cys Ser Asn 
705                 710                 715                 720 


Thr Ile Asp Leu Pro Met Ser Pro Arg Thr Leu Asp Ser Leu Met Gln 
                725                 730                 735     


Phe Gly Asn Asn Gly Glu Gly Ala Glu Pro Ser Ala Gly Gly Gln Phe 
            740                 745                 750         


Glu Ser Leu Thr Phe Asp Met Glu Leu Thr Ser Glu Cys Ala Thr Ser 
        755                 760                 765             


Pro Met 
    770 


<210>  25
<211>  2655
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (122)..(550)

<400>  25
cccagaaggc cgcggggggt ggaccgccta agagggcgtg cgctcccgac atgccccgcg       60

gcgcgccatt aaccgccaga tttgaatcgc gggacccgtt ggcagaggtg gcggcggcgg      120

c atg ggt gcc ccg acg ttg ccc cct gcc tgg cag ccc ttt ctc aag gac      169
  Met Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp         
  1               5                   10                  15              

cac cgc atc tct aca ttc aag aac tgg ccc ttc ttg gag ggc tgc gcc        217
His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala           
            20                  25                  30                    

tgc acc ccg gag cgg atg gcc gag gct ggc ttc atc cac tgc ccc act        265
Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr           
        35                  40                  45                        

gag aac gag cca gac ttg gcc cag tgt ttc ttc tgc ttc aag gag ctg        313
Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu           
    50                  55                  60                            

gaa ggc tgg gag cca gat gac gac ccc ata gag gaa cat aaa aag cat        361
Glu Gly Trp Glu Pro Asp Asp Asp Pro Ile Glu Glu His Lys Lys His           
65                  70                  75                  80            

tcg tcc ggt tgc gct ttc ctt tct gtc aag aag cag ttt gaa gaa tta        409
Ser Ser Gly Cys Ala Phe Leu Ser Val Lys Lys Gln Phe Glu Glu Leu           
                85                  90                  95                

acc ctt ggt gaa ttt ttg aaa ctg gac aga gaa aga gcc aag aac aaa        457
Thr Leu Gly Glu Phe Leu Lys Leu Asp Arg Glu Arg Ala Lys Asn Lys           
            100                 105                 110                   

att gca aag gaa acc aac aat aag aag aaa gaa ttt gag gaa act gcg        505
Ile Ala Lys Glu Thr Asn Asn Lys Lys Lys Glu Phe Glu Glu Thr Ala           
        115                 120                 125                       

gag aaa gtg cgc cgt gcc atc gag cag ctg gct gcc atg gat tga            550
Glu Lys Val Arg Arg Ala Ile Glu Gln Leu Ala Ala Met Asp                   
    130                 135                 140                           

ggcctctggc cggagctgcc tggtcccaga gtggctgcac cacttccagg gtttattccc      610

tggtgccacc agccttcctg tgggcccctt agcaatgtct taggaaagga gatcaacatt      670

ttcaaattag atgtttcaac tgtgctcttg ttttgtcttg aaagtggcac cagaggtgct      730

tctgcctgtg cagcgggtgc tgctggtaac agtggctgct tctctctctc tctctctttt      790

ttgggggctc atttttgctg ttttgattcc cgggcttacc aggtgagaag tgagggagga      850

agaaggcagt gtcccttttg ctagagctga cagctttgtt cgcgtgggca gagccttcca      910

cagtgaatgt gtctggacct catgttgttg aggctgtcac agtcctgagt gtggacttgg      970

caggtgcctg ttgaatctga gctgcaggtt ccttatctgt cacacctgtg cctcctcaga     1030

ggacagtttt tttgttgttg tgtttttttg tttttttttt tttggtagat gcatgacttg     1090

tgtgtgatga gagaatggag acagagtccc tggctcctct actgtttaac aacatggctt     1150

tcttattttg tttgaattgt taattcacag aatagcacaa actacaatta aaactaagca     1210

caaagccatt ctaagtcatt ggggaaacgg ggtgaacttc aggtggatga ggagacagaa     1270

tagagtgata ggaagcgtct ggcagatact ccttttgcca ctgctgtgtg attagacagg     1330

cccagtgagc cgcggggcac atgctggccg ctcctccctc agaaaaaggc agtggcctaa     1390

atccttttta aatgacttgg ctcgatgctg tgggggactg gctgggctgc tgcaggccgt     1450

gtgtctgtca gcccaacctt cacatctgtc acgttctcca cacgggggag agacgcagtc     1510

cgcccaggtc cccgctttct ttggaggcag cagctcccgc agggctgaag tctggcgtaa     1570

gatgatggat ttgattcgcc ctcctccctg tcatagagct gcagggtgga ttgttacagc     1630

ttcgctggaa acctctggag gtcatctcgg ctgttcctga gaaataaaaa gcctgtcatt     1690

tcaaacactg ctgtggaccc tactgggttt ttaaaatatt gtcagttttt catcgtcgtc     1750

cctagcctgc caacagccat ctgcccagac agccgcagtg aggatgagcg tcctggcaga     1810

gacgcagttg tctctgggcg cttgccagag ccacgaaccc cagacctgtt tgtatcatcc     1870

gggctccttc cgggcagaaa caactgaaaa tgcacttcag acccacttat ttctgccaca     1930

tctgagtcgg cctgagatag acttttccct ctaaactggg agaatatcac agtggttttt     1990

gttagcagaa aatgcactcc agcctctgta ctcatctaag ctgcttattt ttgatatttg     2050

tgtcagtctg taaatggata cttcacttta ataactgttg cttagtaatt ggctttgtag     2110

agaagctgga aaaaaatggt tttgtcttca actcctttgc atgccaggcg gtgatgtgga     2170

tctcggcttc tgtgagcctg tgctgtgggc agggctgagc tggagccgcc cctctcagcc     2230

cgcctgccac ggcctttcct taaaggccat ccttaaaacc agaccctcat ggctaccagc     2290

acctgaaagc ttcctcgaca tctgttaata aagccgtagg cccttgtcta agtgcaaccg     2350

cctagacttt ctttcagata catgtccaca tgtccatttt tcaggttctc taagttggag     2410

tggagtctgg gaagggttgt gaatgaggct tctgggctat gggtgaggtt ccaatggcag     2470

gttagagccc ctcgggccaa ctgccatcct ggaaagtaga gacagcagtg cccgctgccc     2530

agaagagacc agcaagccaa actggagccc ccattgcagg ctgtcgccat gtggaaagag     2590

taactcacaa ttgccaataa agtctcatgt ggttttatct aaaaaaaaaa aaaaaaaaaa     2650

aaaaa                                                                 2655


<210>  26
<211>  142
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Gly Ala Pro Thr Leu Pro Pro Ala Trp Gln Pro Phe Leu Lys Asp 
1               5                   10                  15      


His Arg Ile Ser Thr Phe Lys Asn Trp Pro Phe Leu Glu Gly Cys Ala 
            20                  25                  30          


Cys Thr Pro Glu Arg Met Ala Glu Ala Gly Phe Ile His Cys Pro Thr 
        35                  40                  45              


Glu Asn Glu Pro Asp Leu Ala Gln Cys Phe Phe Cys Phe Lys Glu Leu 
    50                  55                  60                  


Glu Gly Trp Glu Pro Asp Asp Asp Pro Ile Glu Glu His Lys Lys His 
65                  70                  75                  80  


Ser Ser Gly Cys Ala Phe Leu Ser Val Lys Lys Gln Phe Glu Glu Leu 
                85                  90                  95      


Thr Leu Gly Glu Phe Leu Lys Leu Asp Arg Glu Arg Ala Lys Asn Lys 
            100                 105                 110         


Ile Ala Lys Glu Thr Asn Asn Lys Lys Lys Glu Phe Glu Glu Thr Ala 
        115                 120                 125             


Glu Lys Val Arg Arg Ala Ile Glu Gln Leu Ala Ala Met Asp 
    130                 135                 140         


<210>  27
<211>  6492
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (494)..(1213)

<400>  27
tttctgtgaa gcagaagtct gggaatcgat ctggaaatcc tcctaatttt tactccctct       60

ccccgcgact cctgattcat tgggaagttt caaatcagct ataactggag agtgctgaag      120

attgatggga tcgttgcctt atgcatttgt tttggtttta caaaaaggaa acttgacaga      180

ggatcatgct gtacttaaaa aatacaacat cacagaggaa gtagactgat attaacaata      240

cttactaata ataacgtgcc tcatgaaata aagatccgaa aggaattgga ataaaaattt      300

cctgcatctc atgccaaggg ggaaacacca gaatcaagtg ttccgcgtga ttgaagacac      360

cccctcgtcc aagaatgcaa agcacatcca ataaaatagc tggattataa ctcctcttct      420

ttctctgggg gccgtggggt gggagctggg gcgagaggtg ccgttggccc ccgttgcttt      480

tcctctggga agg atg gcg cac gct ggg aga aca ggg tac gat aac cgg         529
               Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg            
               1               5                   10                     

gag ata gtg atg aag tac atc cat tat aag ctg tcg cag agg ggc tac        577
Glu Ile Val Met Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr           
        15                  20                  25                        

gag tgg gat gcg gga gat gtg ggc gcc gcg ccc ccg ggg gcc gcc ccc        625
Glu Trp Asp Ala Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro           
    30                  35                  40                            

gca ccg ggc atc ttc tcc tcc cag ccc ggg cac acg ccc cat cca gcc        673
Ala Pro Gly Ile Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala           
45                  50                  55                  60            

gca tcc cgg gac ccg gtc gcc agg acc tcg ccg ctg cag acc ccg gct        721
Ala Ser Arg Asp Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala           
                65                  70                  75                

gcc ccc ggc gcc gcc gcg ggg cct gcg ctc agc ccg gtg cca cct gtg        769
Ala Pro Gly Ala Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val           
            80                  85                  90                    

gtc cac ctg acc ctc cgc cag gcc ggc gac gac ttc tcc cgc cgc tac        817
Val His Leu Thr Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr           
        95                  100                 105                       

cgc cgc gac ttc gcc gag atg tcc agc cag ctg cac ctg acg ccc ttc        865
Arg Arg Asp Phe Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe           
    110                 115                 120                           

acc gcg cgg gga cgc ttt gcc acg gtg gtg gag gag ctc ttc agg gac        913
Thr Ala Arg Gly Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp           
125                 130                 135                 140           

ggg gtg aac tgg ggg agg att gtg gcc ttc ttt gag ttc ggt ggg gtc        961
Gly Val Asn Trp Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val           
                145                 150                 155               

atg tgt gtg gag agc gtc aac cgg gag atg tcg ccc ctg gtg gac aac       1009
Met Cys Val Glu Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn           
            160                 165                 170                   

atc gcc ctg tgg atg act gag tac ctg aac cgg cac ctg cac acc tgg       1057
Ile Ala Leu Trp Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp           
        175                 180                 185                       

atc cag gat aac gga ggc tgg gat gcc ttt gtg gaa ctg tac ggc ccc       1105
Ile Gln Asp Asn Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro           
    190                 195                 200                           

agc atg cgg cct ctg ttt gat ttc tcc tgg ctg tct ctg aag act ctg       1153
Ser Met Arg Pro Leu Phe Asp Phe Ser Trp Leu Ser Leu Lys Thr Leu           
205                 210                 215                 220           

ctc agt ttg gcc ctg gtg gga gct tgc atc acc ctg ggt gcc tat ctg       1201
Leu Ser Leu Ala Leu Val Gly Ala Cys Ile Thr Leu Gly Ala Tyr Leu           
                225                 230                 235               

ggc cac aag tga agtcaacatg cctgccccaa acaaatatgc aaaaggttca           1253
Gly His Lys                                                               
                                                                          

ctaaagcagt agaaataata tgcattgtca gtgatgtacc atgaaacaaa gctgcaggct     1313

gtttaagaaa aaataacaca catataaaca tcacacacac agacagacac acacacacac     1373

aacaattaac agtcttcagg caaaacgtcg aatcagctat ttactgccaa agggaaatat     1433

catttatttt ttacattatt aagaaaaaaa gatttattta tttaagacag tcccatcaaa     1493

actcctgtct ttggaaatcc gaccactaat tgccaagcac cgcttcgtgt ggctccacct     1553

ggatgttctg tgcctgtaaa catagattcg ctttccatgt tgttggccgg atcaccatct     1613

gaagagcaga cggatggaaa aaggacctga tcattgggga agctggcttt ctggctgctg     1673

gaggctgggg agaaggtgtt cattcacttg catttctttg ccctgggggc tgtgatatta     1733

acagagggag ggttcctgtg gggggaagtc catgcctccc tggcctgaag aagagactct     1793

ttgcatatga ctcacatgat gcatacctgg tgggaggaaa agagttggga acttcagatg     1853

gacctagtac ccactgagat ttccacgccg aaggacagcg atgggaaaaa tgcccttaaa     1913

tcataggaaa gtattttttt aagctaccaa ttgtgccgag aaaagcattt tagcaattta     1973

tacaatatca tccagtacct taagccctga ttgtgtatat tcatatattt tggatacgca     2033

ccccccaact cccaatactg gctctgtctg agtaagaaac agaatcctct ggaacttgag     2093

gaagtgaaca tttcggtgac ttccgcatca ggaaggctag agttacccag agcatcaggc     2153

cgccacaagt gcctgctttt aggagaccga agtccgcaga acctgcctgt gtcccagctt     2213

ggaggcctgg tcctggaact gagccggggc cctcactggc ctcctccagg gatgatcaac     2273

agggcagtgt ggtctccgaa tgtctggaag ctgatggagc tcagaattcc actgtcaaga     2333

aagagcagta gaggggtgtg gctgggcctg tcaccctggg gccctccagg taggcccgtt     2393

ttcacgtgga gcatgggagc cacgaccctt cttaagacat gtatcactgt agagggaagg     2453

aacagaggcc ctgggccctt cctatcagaa ggacatggtg aaggctggga acgtgaggag     2513

aggcaatggc cacggcccat tttggctgta gcacatggca cgttggctgt gtggccttgg     2573

cccacctgtg agtttaaagc aaggctttaa atgactttgg agagggtcac aaatcctaaa     2633

agaagcattg aagtgaggtg tcatggatta attgacccct gtctatggaa ttacatgtaa     2693

aacattatct tgtcactgta gtttggtttt atttgaaaac ctgacaaaaa aaaagttcca     2753

ggtgtggaat atgggggtta tctgtacatc ctggggcatt aaaaaaaaaa tcaatggtgg     2813

ggaactataa agaagtaaca aaagaagtga catcttcagc aaataaacta ggaaattttt     2873

ttttcttcca gtttagaatc agccttgaaa cattgatgga ataactctgt ggcattattg     2933

cattatatac catttatctg tattaacttt ggaatgtact ctgttcaatg tttaatgctg     2993

tggttgatat ttcgaaagct gctttaaaaa aatacatgca tctcagcgtt tttttgtttt     3053

taattgtatt tagttatggc ctatacacta tttgtgagca aaggtgatcg ttttctgttt     3113

gagattttta tctcttgatt cttcaaaagc attctgagaa ggtgagataa gccctgagtc     3173

tcagctacct aagaaaaacc tggatgtcac tggccactga ggagctttgt ttcaaccaag     3233

tcatgtgcat ttccacgtca acagaattgt ttattgtgac agttatatct gttgtccctt     3293

tgaccttgtt tcttgaaggt ttcctcgtcc ctgggcaatt ccgcatttaa ttcatggtat     3353

tcaggattac atgcatgttt ggttaaaccc atgagattca ttcagttaaa aatccagatg     3413

gcaaatgacc agcagattca aatctatggt ggtttgacct ttagagagtt gctttacgtg     3473

gcctgtttca acacagaccc acccagagcc ctcctgccct ccttccgcgg gggctttctc     3533

atggctgtcc ttcagggtct tcctgaaatg cagtggtgct tacgctccac caagaaagca     3593

ggaaacctgt ggtatgaagc cagacctccc cggcgggcct cagggaacag aatgatcaga     3653

cctttgaatg attctaattt ttaagcaaaa tattatttta tgaaaggttt acattgtcaa     3713

agtgatgaat atggaatatc caatcctgtg ctgctatcct gccaaaatca ttttaatgga     3773

gtcagtttgc agtatgctcc acgtggtaag atcctccaag ctgctttaga agtaacaatg     3833

aagaacgtgg acgtttttaa tataaagcct gttttgtctt ttgttgttgt tcaaacggga     3893

ttcacagagt atttgaaaaa tgtatatata ttaagaggtc acgggggcta attgctggct     3953

ggctgccttt tgctgtgggg ttttgttacc tggttttaat aacagtaaat gtgcccagcc     4013

tcttggcccc agaactgtac agtattgtgg ctgcacttgc tctaagagta gttgatgttg     4073

cattttcctt attgttaaaa acatgttaga agcaatgaat gtatataaaa gcctcaacta     4133

gtcatttttt tctcctcttc ttttttttca ttatatctaa ttattttgca gttgggcaac     4193

agagaaccat ccctattttg tattgaagag ggattcacat ctgcatctta actgctcttt     4253

atgaatgaaa aaacagtcct ctgtatgtac tcctctttac actggccagg gtcagagtta     4313

aatagagtat atgcactttc caaattgggg acaagggctc taaaaaaagc cccaaaagga     4373

gaagaacatc tgagaacctc ctcggccctc ccagtccctc gctgcacaaa tactccgcaa     4433

gagaggccag aatgacagct gacagggtct atggccatcg ggtcgtctcc gaagatttgg     4493

caggggcaga aaactctggc aggcttaaga tttggaataa agtcacagaa ttaaggaagc     4553

acctcaattt agttcaaaca agacgccaac attctctcca cagctcactt acctctctgt     4613

gttcagatgt ggccttccat ttatatgtga tctttgtttt attagtaaat gcttatcatc     4673

taaagatgta gctctggccc agtgggaaaa attaggaagt gattataaat cgagaggagt     4733

tataataatc aagattaaat gtaaataatc agggcaatcc caacacatgt ctagctttca     4793

cctccaggat ctattgagtg aacagaattg caaatagtct ctatttgtaa ttgaacttat     4853

cctaaaacaa atagtttata aatgtgaact taaactctaa ttaattccaa ctgtactttt     4913

aaggcagtgg ctgtttttag actttcttat cacttatagt tagtaatgta cacctactct     4973

atcagagaaa aacaggaaag gctcgaaata caagccattc taaggaaatt agggagtcag     5033

ttgaaattct attctgatct tattctgtgg tgtcttttgc agcccagaca aatgtggtta     5093

cacacttttt aagaaataca attctacatt gtcaagctta tgaaggttcc aatcagatct     5153

ttattgttat tcaatttgga tctttcaggg attttttttt taaattatta tgggacaaag     5213

gacatttgtt ggaggggtgg gagggaggaa gaatttttaa atgtaaaaca ttcccaagtt     5273

tggatcaggg agttggaagt tttcagaata accagaacta agggtatgaa ggacctgtat     5333

tggggtcgat gtgatgcctc tgcgaagaac cttgtgtgac aaatgagaaa cattttgaag     5393

tttgtggtac gacctttaga ttccagagac atcagcatgg ctcaaagtgc agctccgttt     5453

ggcagtgcaa tggtataaat ttcaagctgg atatgtctaa tgggtattta aacaataaat     5513

gtgcagtttt aactaacagg atatttaatg acaaccttct ggttggtagg gacatctgtt     5573

tctaaatgtt tattatgtac aatacagaaa aaaattttat aaaattaagc aatgtgaaac     5633

tgaattggag agtgataata caagtccttt agtcttaccc agtgaatcat tctgttccat     5693

gtctttggac aaccatgacc ttggacaatc atgaaatatg catctcactg gatgcaaaga     5753

aaatcagatg gagcatgaat ggtactgtac cggttcatct ggactgcccc agaaaaataa     5813

cttcaagcaa acatcctatc aacaacaagg ttgttctgca taccaagctg agcacagaag     5873

atgggaacac tggtggagga tggaaaggct cgctcaatca agaaaattct gagactatta     5933

ataaataaga ctgtagtgta gatactgagt aaatccatgc acctaaacct tttggaaaat     5993

ctgccgtggg ccctccagat agctcatttc attaagtttt tccctccaag gtagaatttg     6053

caagagtgac agtggattgc atttcttttg gggaagcttt cttttggtgg ttttgtttat     6113

tataccttct taagttttca accaaggttt gcttttgttt tgagttactg gggttatttt     6173

tgttttaaat aaaaataagt gtacaataag tgtttttgta ttgaaagctt ttgttatcaa     6233

gattttcata cttttacctt ccatggctct ttttaagatt gatactttta agaggtggct     6293

gatattctgc aacactgtac acataaaaaa tacggtaagg atactttaca tggttaaggt     6353

aaagtaagtc tccagttggc caccattagc tataatggca ctttgtttgt gttgttggaa     6413

aaagtcacat tgccattaaa ctttccttgt ctgtctagtt aatattgtga agaaaaataa     6473

agtacagtgt gagatactg                                                  6492


<210>  28
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ala His Ala Gly Arg Thr Gly Tyr Asp Asn Arg Glu Ile Val Met 
1               5                   10                  15      


Lys Tyr Ile His Tyr Lys Leu Ser Gln Arg Gly Tyr Glu Trp Asp Ala 
            20                  25                  30          


Gly Asp Val Gly Ala Ala Pro Pro Gly Ala Ala Pro Ala Pro Gly Ile 
        35                  40                  45              


Phe Ser Ser Gln Pro Gly His Thr Pro His Pro Ala Ala Ser Arg Asp 
    50                  55                  60                  


Pro Val Ala Arg Thr Ser Pro Leu Gln Thr Pro Ala Ala Pro Gly Ala 
65                  70                  75                  80  


Ala Ala Gly Pro Ala Leu Ser Pro Val Pro Pro Val Val His Leu Thr 
                85                  90                  95      


Leu Arg Gln Ala Gly Asp Asp Phe Ser Arg Arg Tyr Arg Arg Asp Phe 
            100                 105                 110         


Ala Glu Met Ser Ser Gln Leu His Leu Thr Pro Phe Thr Ala Arg Gly 
        115                 120                 125             


Arg Phe Ala Thr Val Val Glu Glu Leu Phe Arg Asp Gly Val Asn Trp 
    130                 135                 140                 


Gly Arg Ile Val Ala Phe Phe Glu Phe Gly Gly Val Met Cys Val Glu 
145                 150                 155                 160 


Ser Val Asn Arg Glu Met Ser Pro Leu Val Asp Asn Ile Ala Leu Trp 
                165                 170                 175     


Met Thr Glu Tyr Leu Asn Arg His Leu His Thr Trp Ile Gln Asp Asn 
            180                 185                 190         


Gly Gly Trp Asp Ala Phe Val Glu Leu Tyr Gly Pro Ser Met Arg Pro 
        195                 200                 205             


Leu Phe Asp Phe Ser Trp Leu Ser Leu Lys Thr Leu Leu Ser Leu Ala 
    210                 215                 220                 


Leu Val Gly Ala Cys Ile Thr Leu Gly Ala Tyr Leu Gly His Lys 
225                 230                 235                 


<210>  29
<211>  2004
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (376)..(1818)

<400>  29
aacatttcag ccggtgggtg gcggggatta ggcgtgaagc ggttcagcag gcagaggttc       60

tcggacgccc tccggcgaag ccacctgttg atgcttttga ctttctgtcc ttgttcctcg      120

tcccatctgg agcatttcca attctggttt tgcggagcag caggtctgag cttgtccggc      180

gagggtggga gttggtcccg gcggagatcc agtgggaaga gccggcggct gcccgggcaa      240

ctcccccact ggaaaggatt ctgaaagaaa tgaagtcagc cctcagaaat gaagttgact      300

gcctgctggc tttctgttga ctggcccgga gctgtactgc aagacccttg tgagcttccc      360

tagtctaaga gtagg atg tct gct gaa gtc atc cat cag gtt gaa gaa gca       411
                 Met Ser Ala Glu Val Ile His Gln Val Glu Glu Ala          
                 1               5                   10                   

ctt gat aca gat gag aag gag atg ctg ctc ttt ttg tgc cgg gat gtt        459
Leu Asp Thr Asp Glu Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val           
        15                  20                  25                        

gct ata gat gtg gtt cca cct aat gtc agg gac ctt ctg gat att tta        507
Ala Ile Asp Val Val Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu           
    30                  35                  40                            

cgg gaa aga ggt aag ctg tct gtc ggg gac ttg gct gaa ctg ctc tac        555
Arg Glu Arg Gly Lys Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr           
45                  50                  55                  60            

aga gtg agg cga ttt gac ctg ctc aaa cgt atc ttg aag atg gac aga        603
Arg Val Arg Arg Phe Asp Leu Leu Lys Arg Ile Leu Lys Met Asp Arg           
                65                  70                  75                

aaa gct gtg gag acc cac ctg ctc agg aac cct cac ctt gtt tcg gac        651
Lys Ala Val Glu Thr His Leu Leu Arg Asn Pro His Leu Val Ser Asp           
            80                  85                  90                    

tat aga gtg ctg atg gca gag att ggt gag gat ttg gat aaa tct gat        699
Tyr Arg Val Leu Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp           
        95                  100                 105                       

gtg tcc tca tta att ttc ctc atg aag gat tac atg ggc cga ggc aag        747
Val Ser Ser Leu Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys           
    110                 115                 120                           

ata agc aag gag aag agt ttc ttg gac ctt gtg gtt gag ttg gag aaa        795
Ile Ser Lys Glu Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys           
125                 130                 135                 140           

cta aat ctg gtt gcc cca gat caa ctg gat tta tta gaa aaa tgc cta        843
Leu Asn Leu Val Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu           
                145                 150                 155               

aag aac atc cac aga ata gac ctg aag aca aaa atc cag aag tac aag        891
Lys Asn Ile His Arg Ile Asp Leu Lys Thr Lys Ile Gln Lys Tyr Lys           
            160                 165                 170                   

cag tct gtt caa gga gca ggg aca agt tac agg aat gtt ctc caa gca        939
Gln Ser Val Gln Gly Ala Gly Thr Ser Tyr Arg Asn Val Leu Gln Ala           
        175                 180                 185                       

gca atc caa aag agt ctc aag gat cct tca aat aac ttc agg ctc cat        987
Ala Ile Gln Lys Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Leu His           
    190                 195                 200                           

aat ggg aga agt aaa gaa caa aga ctt aag gaa cag ctt ggc gct caa       1035
Asn Gly Arg Ser Lys Glu Gln Arg Leu Lys Glu Gln Leu Gly Ala Gln           
205                 210                 215                 220           

caa gaa cca gtg aag aaa tcc att cag gaa tca gaa gct ttt ttg cct       1083
Gln Glu Pro Val Lys Lys Ser Ile Gln Glu Ser Glu Ala Phe Leu Pro           
                225                 230                 235               

cag agc ata cct gaa gag aga tac aag atg aag agc aag ccc cta gga       1131
Gln Ser Ile Pro Glu Glu Arg Tyr Lys Met Lys Ser Lys Pro Leu Gly           
            240                 245                 250                   

atc tgc ctg ata atc gat tgc att ggc aat gag aca gag ctt ctt cga       1179
Ile Cys Leu Ile Ile Asp Cys Ile Gly Asn Glu Thr Glu Leu Leu Arg           
        255                 260                 265                       

gac acc ttc act tcc ctg ggc tat gaa gtc cag aaa ttc ttg cat ctc       1227
Asp Thr Phe Thr Ser Leu Gly Tyr Glu Val Gln Lys Phe Leu His Leu           
    270                 275                 280                           

agt atg cat ggt ata tcc cag att ctt ggc caa ttt gcc tgt atg ccc       1275
Ser Met His Gly Ile Ser Gln Ile Leu Gly Gln Phe Ala Cys Met Pro           
285                 290                 295                 300           

gag cac cga gac tac gac agc ttt gtg tgt gtc ctg gtg agc cga gga       1323
Glu His Arg Asp Tyr Asp Ser Phe Val Cys Val Leu Val Ser Arg Gly           
                305                 310                 315               

ggc tcc cag agt gtg tat ggt gtg gat cag act cac tca ggg ctc ccc       1371
Gly Ser Gln Ser Val Tyr Gly Val Asp Gln Thr His Ser Gly Leu Pro           
            320                 325                 330                   

ctg cat cac atc agg agg atg ttc atg gga gat tca tgc cct tat cta       1419
Leu His His Ile Arg Arg Met Phe Met Gly Asp Ser Cys Pro Tyr Leu           
        335                 340                 345                       

gca ggg aag cca aag atg ttt ttt att cag aac tat gtg gtg tca gag       1467
Ala Gly Lys Pro Lys Met Phe Phe Ile Gln Asn Tyr Val Val Ser Glu           
    350                 355                 360                           

ggc cag ctg gag gac agc agc ctc ttg gag gtg gat ggg cca gcg atg       1515
Gly Gln Leu Glu Asp Ser Ser Leu Leu Glu Val Asp Gly Pro Ala Met           
365                 370                 375                 380           

aag aat gtg gaa ttc aag gct cag aag cga ggg ctg tgc aca gtt cac       1563
Lys Asn Val Glu Phe Lys Ala Gln Lys Arg Gly Leu Cys Thr Val His           
                385                 390                 395               

cga gaa gct gac ttc ttc tgg agc ctg tgt act gcg gac atg tcc ctg       1611
Arg Glu Ala Asp Phe Phe Trp Ser Leu Cys Thr Ala Asp Met Ser Leu           
            400                 405                 410                   

ctg gag cag tct cac agc tca cca tcc ctg tac ctg cag tgc ctc tcc       1659
Leu Glu Gln Ser His Ser Ser Pro Ser Leu Tyr Leu Gln Cys Leu Ser           
        415                 420                 425                       

cag aaa ctg aga caa gaa aga aaa cgc cca ctc ctg gat ctt cac att       1707
Gln Lys Leu Arg Gln Glu Arg Lys Arg Pro Leu Leu Asp Leu His Ile           
    430                 435                 440                           

gaa ctc aat ggc tac atg tat gat tgg aac agc aga gtt tct gcc aag       1755
Glu Leu Asn Gly Tyr Met Tyr Asp Trp Asn Ser Arg Val Ser Ala Lys           
445                 450                 455                 460           

gag aaa tat tat gtc tgg ctg cag cac act ctg aga aag aaa ctt atc       1803
Glu Lys Tyr Tyr Val Trp Leu Gln His Thr Leu Arg Lys Lys Leu Ile           
                465                 470                 475               

ctc tcc tac aca taa gaaaccaaaa ggctgggcgt agtggctcac acctgtaatc       1858
Leu Ser Tyr Thr                                                           
            480                                                           

ccagcacttt gggaggccaa ggagggcaga tcacttcagg tcaggagttc gagaccagcc     1918

tggccaacat ggtaaacgct gtccctagta aaaatacaaa aattaaaaaa aaaaaaaaaa     1978

aaaaaaaaaa aaaaaaaaaa aaaaaa                                          2004


<210>  30
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Ser Ala Glu Val Ile His Gln Val Glu Glu Ala Leu Asp Thr Asp 
1               5                   10                  15      


Glu Lys Glu Met Leu Leu Phe Leu Cys Arg Asp Val Ala Ile Asp Val 
            20                  25                  30          


Val Pro Pro Asn Val Arg Asp Leu Leu Asp Ile Leu Arg Glu Arg Gly 
        35                  40                  45              


Lys Leu Ser Val Gly Asp Leu Ala Glu Leu Leu Tyr Arg Val Arg Arg 
    50                  55                  60                  


Phe Asp Leu Leu Lys Arg Ile Leu Lys Met Asp Arg Lys Ala Val Glu 
65                  70                  75                  80  


Thr His Leu Leu Arg Asn Pro His Leu Val Ser Asp Tyr Arg Val Leu 
                85                  90                  95      


Met Ala Glu Ile Gly Glu Asp Leu Asp Lys Ser Asp Val Ser Ser Leu 
            100                 105                 110         


Ile Phe Leu Met Lys Asp Tyr Met Gly Arg Gly Lys Ile Ser Lys Glu 
        115                 120                 125             


Lys Ser Phe Leu Asp Leu Val Val Glu Leu Glu Lys Leu Asn Leu Val 
    130                 135                 140                 


Ala Pro Asp Gln Leu Asp Leu Leu Glu Lys Cys Leu Lys Asn Ile His 
145                 150                 155                 160 


Arg Ile Asp Leu Lys Thr Lys Ile Gln Lys Tyr Lys Gln Ser Val Gln 
                165                 170                 175     


Gly Ala Gly Thr Ser Tyr Arg Asn Val Leu Gln Ala Ala Ile Gln Lys 
            180                 185                 190         


Ser Leu Lys Asp Pro Ser Asn Asn Phe Arg Leu His Asn Gly Arg Ser 
        195                 200                 205             


Lys Glu Gln Arg Leu Lys Glu Gln Leu Gly Ala Gln Gln Glu Pro Val 
    210                 215                 220                 


Lys Lys Ser Ile Gln Glu Ser Glu Ala Phe Leu Pro Gln Ser Ile Pro 
225                 230                 235                 240 


Glu Glu Arg Tyr Lys Met Lys Ser Lys Pro Leu Gly Ile Cys Leu Ile 
                245                 250                 255     


Ile Asp Cys Ile Gly Asn Glu Thr Glu Leu Leu Arg Asp Thr Phe Thr 
            260                 265                 270         


Ser Leu Gly Tyr Glu Val Gln Lys Phe Leu His Leu Ser Met His Gly 
        275                 280                 285             


Ile Ser Gln Ile Leu Gly Gln Phe Ala Cys Met Pro Glu His Arg Asp 
    290                 295                 300                 


Tyr Asp Ser Phe Val Cys Val Leu Val Ser Arg Gly Gly Ser Gln Ser 
305                 310                 315                 320 


Val Tyr Gly Val Asp Gln Thr His Ser Gly Leu Pro Leu His His Ile 
                325                 330                 335     


Arg Arg Met Phe Met Gly Asp Ser Cys Pro Tyr Leu Ala Gly Lys Pro 
            340                 345                 350         


Lys Met Phe Phe Ile Gln Asn Tyr Val Val Ser Glu Gly Gln Leu Glu 
        355                 360                 365             


Asp Ser Ser Leu Leu Glu Val Asp Gly Pro Ala Met Lys Asn Val Glu 
    370                 375                 380                 


Phe Lys Ala Gln Lys Arg Gly Leu Cys Thr Val His Arg Glu Ala Asp 
385                 390                 395                 400 


Phe Phe Trp Ser Leu Cys Thr Ala Asp Met Ser Leu Leu Glu Gln Ser 
                405                 410                 415     


His Ser Ser Pro Ser Leu Tyr Leu Gln Cys Leu Ser Gln Lys Leu Arg 
            420                 425                 430         


Gln Glu Arg Lys Arg Pro Leu Leu Asp Leu His Ile Glu Leu Asn Gly 
        435                 440                 445             


Tyr Met Tyr Asp Trp Asn Ser Arg Val Ser Ala Lys Glu Lys Tyr Tyr 
    450                 455                 460                 


Val Trp Leu Gln His Thr Leu Arg Lys Lys Leu Ile Leu Ser Tyr Thr 
465                 470                 475                 480 


<210>  31
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  31
aguccaggau uauagcccct t                                                 21


<210>  32
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  32
aacaucugcc uagaucggcu att                                               23


<210>  33
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  33
catttcccgt aaatc                                                        15


<210>  34
<211>  1669
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (170)..(871)

<400>  34
ctccctcagc aaggacagca gaggaccagc taagagggag agaagcaact acagaccccc       60

cctgaaaaca accctcagac gccacatccc ctgacaagct gccaggcagg ttctcttcct      120

ctcacatact gacccacggc tccaccctct ctcccctgga aaggacacc atg agc act      178
                                                      Met Ser Thr         
                                                      1                   

gaa agc atg atc cgg gac gtg gag ctg gcc gag gag gcg ctc ccc aag        226
Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala Leu Pro Lys           
    5                   10                  15                            

aag aca ggg ggg ccc cag ggc tcc agg cgg tgc ttg ttc ctc agc ctc        274
Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe Leu Ser Leu           
20                  25                  30                  35            

ttc tcc ttc ctg atc gtg gca ggc gcc acc acg ctc ttc tgc ctg ctg        322
Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe Cys Leu Leu           
                40                  45                  50                

cac ttt gga gtg atc ggc ccc cag agg gaa gag ttc ccc agg gac ctc        370
His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro Arg Asp Leu           
            55                  60                  65                    

tct cta atc agc cct ctg gcc cag gca gtc aga tca tct tct cga acc        418
Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser Ser Arg Thr           
        70                  75                  80                        

ccg agt gac aag cct gta gcc cat gtt gta gca aac cct caa gct gag        466
Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro Gln Ala Glu           
    85                  90                  95                            

ggg cag ctc cag tgg ctg aac cgc cgg gcc aat gcc ctc ctg gcc aat        514
Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu Leu Ala Asn           
100                 105                 110                 115           

ggc gtg gag ctg aga gat aac cag ctg gtg gtg cca tca gag ggc ctg        562
Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser Glu Gly Leu           
                120                 125                 130               

tac ctc atc tac tcc cag gtc ctc ttc aag ggc caa ggc tgc ccc tcc        610
Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly Cys Pro Ser           
            135                 140                 145                   

acc cat gtg ctc ctc acc cac acc atc agc cgc atc gcc gtc tcc tac        658
Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala Val Ser Tyr           
        150                 155                 160                       

cag acc aag gtc aac ctc ctc tct gcc atc aag agc ccc tgc cag agg        706
Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro Cys Gln Arg           
    165                 170                 175                           

gag acc cca gag ggg gct gag gcc aag ccc tgg tat gag ccc atc tat        754
Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu Pro Ile Tyr           
180                 185                 190                 195           

ctg gga ggg gtc ttc cag ctg gag aag ggt gac cga ctc agc gct gag        802
Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu Ser Ala Glu           
                200                 205                 210               

atc aat cgg ccc gac tat ctc gac ttt gcc gag tct ggg cag gtc tac        850
Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly Gln Val Tyr           
            215                 220                 225                   

ttt ggg atc att gcc ctg tga ggaggacgaa catccaacct tcccaaacgc           901
Phe Gly Ile Ile Ala Leu                                                   
        230                                                               

ctcccctgcc ccaatccctt tattaccccc tccttcagac accctcaacc tcttctggct      961

caaaaagaga attgggggct tagggtcgga acccaagctt agaactttaa gcaacaagac     1021

caccacttcg aaacctggga ttcaggaatg tgtggcctgc acagtgaagt gctggcaacc     1081

actaagaatt caaactgggg cctccagaac tcactggggc ctacagcttt gatccctgac     1141

atctggaatc tggagaccag ggagcctttg gttctggcca gaatgctgca ggacttgaga     1201

agacctcacc tagaaattga cacaagtgga ccttaggcct tcctctctcc agatgtttcc     1261

agacttcctt gagacacgga gcccagccct ccccatggag ccagctccct ctatttatgt     1321

ttgcacttgt gattatttat tatttattta ttatttattt atttacagat gaatgtattt     1381

atttgggaga ccggggtatc ctgggggacc caatgtagga gctgccttgg ctcagacatg     1441

ttttccgtga aaacggagct gaacaatagg ctgttcccat gtagccccct ggcctctgtg     1501

ccttcttttg attatgtttt ttaaaatatt tatctgatta agttgtctaa acaatgctga     1561

tttggtgacc aactgtcact cattgctgag cctctgctcc ccaggggagt tgtgtctgta     1621

atcgccctac tattcagtgg cgagaaataa agtttgctta gaaaagaa                  1669


<210>  35
<211>  233
<212>  PRT
<213>  Homo sapiens

<400>  35

Met Ser Thr Glu Ser Met Ile Arg Asp Val Glu Leu Ala Glu Glu Ala 
1               5                   10                  15      


Leu Pro Lys Lys Thr Gly Gly Pro Gln Gly Ser Arg Arg Cys Leu Phe 
            20                  25                  30          


Leu Ser Leu Phe Ser Phe Leu Ile Val Ala Gly Ala Thr Thr Leu Phe 
        35                  40                  45              


Cys Leu Leu His Phe Gly Val Ile Gly Pro Gln Arg Glu Glu Phe Pro 
    50                  55                  60                  


Arg Asp Leu Ser Leu Ile Ser Pro Leu Ala Gln Ala Val Arg Ser Ser 
65                  70                  75                  80  


Ser Arg Thr Pro Ser Asp Lys Pro Val Ala His Val Val Ala Asn Pro 
                85                  90                  95      


Gln Ala Glu Gly Gln Leu Gln Trp Leu Asn Arg Arg Ala Asn Ala Leu 
            100                 105                 110         


Leu Ala Asn Gly Val Glu Leu Arg Asp Asn Gln Leu Val Val Pro Ser 
        115                 120                 125             


Glu Gly Leu Tyr Leu Ile Tyr Ser Gln Val Leu Phe Lys Gly Gln Gly 
    130                 135                 140                 


Cys Pro Ser Thr His Val Leu Leu Thr His Thr Ile Ser Arg Ile Ala 
145                 150                 155                 160 


Val Ser Tyr Gln Thr Lys Val Asn Leu Leu Ser Ala Ile Lys Ser Pro 
                165                 170                 175     


Cys Gln Arg Glu Thr Pro Glu Gly Ala Glu Ala Lys Pro Trp Tyr Glu 
            180                 185                 190         


Pro Ile Tyr Leu Gly Gly Val Phe Gln Leu Glu Lys Gly Asp Arg Leu 
        195                 200                 205             


Ser Ala Glu Ile Asn Arg Pro Asp Tyr Leu Asp Phe Ala Glu Ser Gly 
    210                 215                 220                 


Gln Val Tyr Phe Gly Ile Ile Ala Leu 
225                 230             


<210>  36
<211>  1386
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (141)..(758)

<400>  36
gccccatctc cttgggctgc ccgtgcttcg tgctttggac taccgcccag cagtgtcctg       60

ccctctgcct gggcctcggt ccctcctgca cctgctgcct ggatccccgg cctgcctggg      120

cctgggcctt ggttctcccc atg aca cca cct gaa cgt ctc ttc ctc cca agg      173
                      Met Thr Pro Pro Glu Arg Leu Phe Leu Pro Arg         
                      1               5                   10              

gtg tgt ggc acc acc cta cac ctc ctc ctt ctg ggg ctg ctg ctg gtt        221
Val Cys Gly Thr Thr Leu His Leu Leu Leu Leu Gly Leu Leu Leu Val           
            15                  20                  25                    

ctg ctg cct ggg gcc cag ggg ctc cct ggt gtt ggc ctc aca cct tca        269
Leu Leu Pro Gly Ala Gln Gly Leu Pro Gly Val Gly Leu Thr Pro Ser           
        30                  35                  40                        

gct gcc cag act gcc cgt cag cac ccc aag atg cat ctt gcc cac agc        317
Ala Ala Gln Thr Ala Arg Gln His Pro Lys Met His Leu Ala His Ser           
    45                  50                  55                            

acc ctc aaa cct gct gct cac ctc att gga gac ccc agc aag cag aac        365
Thr Leu Lys Pro Ala Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn           
60                  65                  70                  75            

tca ctg ctc tgg aga gca aac acg gac cgt gcc ttc ctc cag gat ggt        413
Ser Leu Leu Trp Arg Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly           
                80                  85                  90                

ttc tcc ttg agc aac aat tct ctc ctg gtc ccc acc agt ggc atc tac        461
Phe Ser Leu Ser Asn Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr           
            95                  100                 105                   

ttc gtc tac tcc cag gtg gtc ttc tct ggg aaa gcc tac tct ccc aag        509
Phe Val Tyr Ser Gln Val Val Phe Ser Gly Lys Ala Tyr Ser Pro Lys           
        110                 115                 120                       

gcc acc tcc tcc cca ctc tac ctg gcc cat gag gtc cag ctc ttc tcc        557
Ala Thr Ser Ser Pro Leu Tyr Leu Ala His Glu Val Gln Leu Phe Ser           
    125                 130                 135                           

tcc cag tac ccc ttc cat gtg cct ctc ctc agc tcc cag aag atg gtg        605
Ser Gln Tyr Pro Phe His Val Pro Leu Leu Ser Ser Gln Lys Met Val           
140                 145                 150                 155           

tat cca ggg ctg cag gaa ccc tgg ctg cac tcg atg tac cac ggg gct        653
Tyr Pro Gly Leu Gln Glu Pro Trp Leu His Ser Met Tyr His Gly Ala           
                160                 165                 170               

gcg ttc cag ctc acc cag gga gac cag cta tcc acc cac aca gat ggc        701
Ala Phe Gln Leu Thr Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly           
            175                 180                 185                   

atc ccc cac cta gtc ctc agc cct agt act gtc ttc ttt gga gcc ttc        749
Ile Pro His Leu Val Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe           
        190                 195                 200                       

gct ctg tag aacttggaaa aatccagaaa gaaaaaataa ttgatttcaa                798
Ala Leu                                                                   
    205                                                                   

gaccttctcc ccattctgcc tccattctga ccatttcagg ggtcgtcacc acctctcctt      858

tggccattcc aacagctcaa gtcttccctg atcaagtcac cggagctttc aaagaaggaa      918

ttctaggcat cccaggggac cacacctccc tgaaccatcc ctgatgtctg tctggctgag      978

gatttcaagc ctgcctagga attcccagcc caaagctgtt ggtctgtccc accagctagg     1038

tggggcctag atccacacac agaggaagag caggcacatg gaggagcttg ggggatgact     1098

agaggcaggg aggggactat ttatgaaggc aaaaaaatta aattatttat ttatggagga     1158

tggagagagg ggaataatag aagaacatcc aaggagaaac agagacaggc ccaagagatg     1218

aagagtgaga gggcatgcgc acaaggctga ccaagagaga aagaagtagg catgagggat     1278

cacagggccc cagaaggcag ggaaaggctc tgaaagccag ctgccgacca gagccccaca     1338

cggaggcatc tgcaccctcg atgaagccca ataaacctct tttctctg                  1386


<210>  37
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  37

Met Thr Pro Pro Glu Arg Leu Phe Leu Pro Arg Val Cys Gly Thr Thr 
1               5                   10                  15      


Leu His Leu Leu Leu Leu Gly Leu Leu Leu Val Leu Leu Pro Gly Ala 
            20                  25                  30          


Gln Gly Leu Pro Gly Val Gly Leu Thr Pro Ser Ala Ala Gln Thr Ala 
        35                  40                  45              


Arg Gln His Pro Lys Met His Leu Ala His Ser Thr Leu Lys Pro Ala 
    50                  55                  60                  


Ala His Leu Ile Gly Asp Pro Ser Lys Gln Asn Ser Leu Leu Trp Arg 
65                  70                  75                  80  


Ala Asn Thr Asp Arg Ala Phe Leu Gln Asp Gly Phe Ser Leu Ser Asn 
                85                  90                  95      


Asn Ser Leu Leu Val Pro Thr Ser Gly Ile Tyr Phe Val Tyr Ser Gln 
            100                 105                 110         


Val Val Phe Ser Gly Lys Ala Tyr Ser Pro Lys Ala Thr Ser Ser Pro 
        115                 120                 125             


Leu Tyr Leu Ala His Glu Val Gln Leu Phe Ser Ser Gln Tyr Pro Phe 
    130                 135                 140                 


His Val Pro Leu Leu Ser Ser Gln Lys Met Val Tyr Pro Gly Leu Gln 
145                 150                 155                 160 


Glu Pro Trp Leu His Ser Met Tyr His Gly Ala Ala Phe Gln Leu Thr 
                165                 170                 175     


Gln Gly Asp Gln Leu Ser Thr His Thr Asp Gly Ile Pro His Leu Val 
            180                 185                 190         


Leu Ser Pro Ser Thr Val Phe Phe Gly Ala Phe Ala Leu 
        195                 200                 205 


<210>  38
<211>  1776
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (96)..(941)

<400>  38
tttcatttcc tcactgacta taaaagaata gagaaggaag ggcttcagtg accggctgcc       60

tggctgactt acagcagtca gactctgaca ggatc atg gct atg atg gag gtc         113
                                       Met Ala Met Met Glu Val            
                                       1               5                  

cag ggg gga ccc agc ctg gga cag acc tgc gtg ctg atc gtg atc ttc        161
Gln Gly Gly Pro Ser Leu Gly Gln Thr Cys Val Leu Ile Val Ile Phe           
            10                  15                  20                    

aca gtg ctc ctg cag tct ctc tgt gtg gct gta act tac gtg tac ttt        209
Thr Val Leu Leu Gln Ser Leu Cys Val Ala Val Thr Tyr Val Tyr Phe           
        25                  30                  35                        

acc aac gag ctg aag cag atg cag gac aag tac tcc aaa agt ggc att        257
Thr Asn Glu Leu Lys Gln Met Gln Asp Lys Tyr Ser Lys Ser Gly Ile           
    40                  45                  50                            

gct tgt ttc tta aaa gaa gat gac agt tat tgg gac ccc aat gac gaa        305
Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr Trp Asp Pro Asn Asp Glu           
55                  60                  65                  70            

gag agt atg aac agc ccc tgc tgg caa gtc aag tgg caa ctc cgt cag        353
Glu Ser Met Asn Ser Pro Cys Trp Gln Val Lys Trp Gln Leu Arg Gln           
                75                  80                  85                

ctc gtt aga aag atg att ttg aga acc tct gag gaa acc att tct aca        401
Leu Val Arg Lys Met Ile Leu Arg Thr Ser Glu Glu Thr Ile Ser Thr           
            90                  95                  100                   

gtt caa gaa aag caa caa aat att tct ccc cta gtg aga gaa aga ggt        449
Val Gln Glu Lys Gln Gln Asn Ile Ser Pro Leu Val Arg Glu Arg Gly           
        105                 110                 115                       

cct cag aga gta gca gct cac ata act ggg acc aga gga aga agc aac        497
Pro Gln Arg Val Ala Ala His Ile Thr Gly Thr Arg Gly Arg Ser Asn           
    120                 125                 130                           

aca ttg tct tct cca aac tcc aag aat gaa aag gct ctg ggc cgc aaa        545
Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu Lys Ala Leu Gly Arg Lys           
135                 140                 145                 150           

ata aac tcc tgg gaa tca tca agg agt ggg cat tca ttc ctg agc aac        593
Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly His Ser Phe Leu Ser Asn           
                155                 160                 165               

ttg cac ttg agg aat ggt gaa ctg gtc atc cat gaa aaa ggg ttt tac        641
Leu His Leu Arg Asn Gly Glu Leu Val Ile His Glu Lys Gly Phe Tyr           
            170                 175                 180                   

tac atc tat tcc caa aca tac ttt cga ttt cag gag gaa ata aaa gaa        689
Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe Gln Glu Glu Ile Lys Glu           
        185                 190                 195                       

aac aca aag aac gac aaa caa atg gtc caa tat att tac aaa tac aca        737
Asn Thr Lys Asn Asp Lys Gln Met Val Gln Tyr Ile Tyr Lys Tyr Thr           
    200                 205                 210                           

agt tat cct gac cct ata ttg ttg atg aaa agt gct aga aat agt tgt        785
Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys Ser Ala Arg Asn Ser Cys           
215                 220                 225                 230           

tgg tct aaa gat gca gaa tat gga ctc tat tcc atc tat caa ggg gga        833
Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr Ser Ile Tyr Gln Gly Gly           
                235                 240                 245               

ata ttt gag ctt aag gaa aat gac aga att ttt gtt tct gta aca aat        881
Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile Phe Val Ser Val Thr Asn           
            250                 255                 260                   

gag cac ttg ata gac atg gac cat gaa gcc agt ttt ttc ggg gcc ttt        929
Glu His Leu Ile Asp Met Asp His Glu Ala Ser Phe Phe Gly Ala Phe           
        265                 270                 275                       

tta gtt ggc taa ctgacctgga aagaaaaagc aataacctca aagtgactat            981
Leu Val Gly                                                               
    280                                                                   

tcagttttca ggatgataca ctatgaagat gtttcaaaaa atctgaccaa aacaaacaaa     1041

cagaaaacag aaaacaaaaa aacctctatg caatctgagt agagcagcca caaccaaaaa     1101

attctacaac acacactgtt ctgaaagtga ctcacttatc ccaagagaat gaaattgctg     1161

aaagatcttt caggactcta cctcatatca gtttgctagc agaaatctag aagactgtca     1221

gcttccaaac attaatgcaa tggttaacat cttctgtctt tataatctac tccttgtaaa     1281

gactgtagaa gaaagagcaa caatccatct ctcaagtagt gtatcacagt agtagcctcc     1341

aggtttcctt aagggacaac atccttaagt caaaagagag aagaggcacc actaaaagat     1401

cgcagtttgc ctggtgcagt ggctcacacc tgtaatccca acattttggg aacccaaggt     1461

gggtagatca cgagatcaag agatcaagac catagtgacc aacatagtga aaccccatct     1521

ctactgaaag tacaaaaatt agctgggtgt gttggcacat gcctgtagtc ccagctactt     1581

gagaggctga ggcaagagaa ttgtttgaac ccgggaggca gaggttgcag tgtggtgaga     1641

tcatgccact acactccagc ctggcgacag agcgagactt ggtttcaaaa aaaaaaaaaa     1701

aaaaaacttc agtaagtacg tgttattttt ttcaataaaa ttctattaca gtatgtcaaa     1761

aaaaaaaaaa aaaaa                                                      1776


<210>  39
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  39

Met Ala Met Met Glu Val Gln Gly Gly Pro Ser Leu Gly Gln Thr Cys 
1               5                   10                  15      


Val Leu Ile Val Ile Phe Thr Val Leu Leu Gln Ser Leu Cys Val Ala 
            20                  25                  30          


Val Thr Tyr Val Tyr Phe Thr Asn Glu Leu Lys Gln Met Gln Asp Lys 
        35                  40                  45              


Tyr Ser Lys Ser Gly Ile Ala Cys Phe Leu Lys Glu Asp Asp Ser Tyr 
    50                  55                  60                  


Trp Asp Pro Asn Asp Glu Glu Ser Met Asn Ser Pro Cys Trp Gln Val 
65                  70                  75                  80  


Lys Trp Gln Leu Arg Gln Leu Val Arg Lys Met Ile Leu Arg Thr Ser 
                85                  90                  95      


Glu Glu Thr Ile Ser Thr Val Gln Glu Lys Gln Gln Asn Ile Ser Pro 
            100                 105                 110         


Leu Val Arg Glu Arg Gly Pro Gln Arg Val Ala Ala His Ile Thr Gly 
        115                 120                 125             


Thr Arg Gly Arg Ser Asn Thr Leu Ser Ser Pro Asn Ser Lys Asn Glu 
    130                 135                 140                 


Lys Ala Leu Gly Arg Lys Ile Asn Ser Trp Glu Ser Ser Arg Ser Gly 
145                 150                 155                 160 


His Ser Phe Leu Ser Asn Leu His Leu Arg Asn Gly Glu Leu Val Ile 
                165                 170                 175     


His Glu Lys Gly Phe Tyr Tyr Ile Tyr Ser Gln Thr Tyr Phe Arg Phe 
            180                 185                 190         


Gln Glu Glu Ile Lys Glu Asn Thr Lys Asn Asp Lys Gln Met Val Gln 
        195                 200                 205             


Tyr Ile Tyr Lys Tyr Thr Ser Tyr Pro Asp Pro Ile Leu Leu Met Lys 
    210                 215                 220                 


Ser Ala Arg Asn Ser Cys Trp Ser Lys Asp Ala Glu Tyr Gly Leu Tyr 
225                 230                 235                 240 


Ser Ile Tyr Gln Gly Gly Ile Phe Glu Leu Lys Glu Asn Asp Arg Ile 
                245                 250                 255     


Phe Val Ser Val Thr Asn Glu His Leu Ile Asp Met Asp His Glu Ala 
            260                 265                 270         


Ser Phe Phe Gly Ala Phe Leu Val Gly 
        275                 280     


<210>  40
<211>  1909
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (158)..(1003)

<400>  40
gaggtgtttc ccttagctat ggaaactcta taagagagat ccagcttgcc tcctcttgag       60

cagtcagcaa cagggtcccg tccttgacac ctcagcctct acaggactga gaagaagtaa      120

aaccgtttgc tggggctggc ctgactcacc agctgcc atg cag cag ccc ttc aat       175
                                         Met Gln Gln Pro Phe Asn          
                                         1               5                

tac cca tat ccc cag atc tac tgg gtg gac agc agt gcc agc tct ccc        223
Tyr Pro Tyr Pro Gln Ile Tyr Trp Val Asp Ser Ser Ala Ser Ser Pro           
            10                  15                  20                    

tgg gcc cct cca ggc aca gtt ctt ccc tgt cca acc tct gtg ccc aga        271
Trp Ala Pro Pro Gly Thr Val Leu Pro Cys Pro Thr Ser Val Pro Arg           
        25                  30                  35                        

agg cct ggt caa agg agg cca cca cca cca ccg cca ccg cca cca cta        319
Arg Pro Gly Gln Arg Arg Pro Pro Pro Pro Pro Pro Pro Pro Pro Leu           
    40                  45                  50                            

cca cct ccg ccg ccg ccg cca cca ctg cct cca cta ccg ctg cca ccc        367
Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro Pro Leu Pro Leu Pro Pro           
55                  60                  65                  70            

ctg aag aag aga ggg aac cac agc aca ggc ctg tgt ctc ctt gtg atg        415
Leu Lys Lys Arg Gly Asn His Ser Thr Gly Leu Cys Leu Leu Val Met           
                75                  80                  85                

ttt ttc atg gtt ctg gtt gcc ttg gta gga ttg ggc ctg ggg atg ttt        463
Phe Phe Met Val Leu Val Ala Leu Val Gly Leu Gly Leu Gly Met Phe           
            90                  95                  100                   

cag ctc ttc cac cta cag aag gag ctg gca gaa ctc cga gag tct acc        511
Gln Leu Phe His Leu Gln Lys Glu Leu Ala Glu Leu Arg Glu Ser Thr           
        105                 110                 115                       

agc cag atg cac aca gca tca tct ttg gag aag caa ata ggc cac ccc        559
Ser Gln Met His Thr Ala Ser Ser Leu Glu Lys Gln Ile Gly His Pro           
    120                 125                 130                           

agt cca ccc cct gaa aaa aag gag ctg agg aaa gtg gcc cat tta aca        607
Ser Pro Pro Pro Glu Lys Lys Glu Leu Arg Lys Val Ala His Leu Thr           
135                 140                 145                 150           

ggc aag tcc aac tca agg tcc atg cct ctg gaa tgg gaa gac acc tat        655
Gly Lys Ser Asn Ser Arg Ser Met Pro Leu Glu Trp Glu Asp Thr Tyr           
                155                 160                 165               

gga att gtc ctg ctt tct gga gtg aag tat aag aag ggt ggc ctt gtg        703
Gly Ile Val Leu Leu Ser Gly Val Lys Tyr Lys Lys Gly Gly Leu Val           
            170                 175                 180                   

atc aat gaa act ggg ctg tac ttt gta tat tcc aaa gta tac ttc cgg        751
Ile Asn Glu Thr Gly Leu Tyr Phe Val Tyr Ser Lys Val Tyr Phe Arg           
        185                 190                 195                       

ggt caa tct tgc aac aac ctg ccc ctg agc cac aag gtc tac atg agg        799
Gly Gln Ser Cys Asn Asn Leu Pro Leu Ser His Lys Val Tyr Met Arg           
    200                 205                 210                           

aac tct aag tat ccc cag gat ctg gtg atg atg gag ggg aag atg atg        847
Asn Ser Lys Tyr Pro Gln Asp Leu Val Met Met Glu Gly Lys Met Met           
215                 220                 225                 230           

agc tac tgc act act ggg cag atg tgg gcc cgc agc agc tac ctg ggg        895
Ser Tyr Cys Thr Thr Gly Gln Met Trp Ala Arg Ser Ser Tyr Leu Gly           
                235                 240                 245               

gca gtg ttc aat ctt acc agt gct gat cat tta tat gtc aac gta tct        943
Ala Val Phe Asn Leu Thr Ser Ala Asp His Leu Tyr Val Asn Val Ser           
            250                 255                 260                   

gag ctc tct ctg gtc aat ttt gag gaa tct cag acg ttt ttc ggc tta        991
Glu Leu Ser Leu Val Asn Phe Glu Glu Ser Gln Thr Phe Phe Gly Leu           
        265                 270                 275                       

tat aag ctc taa gagaagcact ttgggattct ttccattatg attctttgtt           1043
Tyr Lys Leu                                                               
    280                                                                   

acaggcaccg agaatgttgt attcagtgag ggtcttctta catgcatttg aggtcaagta     1103

agaagacatg aaccaagtgg accttgagac cacagggttc aaaatgtctg tagctcctca     1163

actcacctaa tgtttatgag ccagacaaat ggaggaatat gacggaagaa catagaactc     1223

tgggctgcca tgtgaagagg gagaagcatg aaaaagcagc taccaggtgt tctacactca     1283

tcttagtgcc tgagagtatt taggcagatt gaaaaggaca ccttttaact cacctctcaa     1343

ggtgggcctt gctacctcaa gggggactgt ctttcagata catggttgtg acctgaggat     1403

ttaagggatg gaaaaggaag actagaggct tgcataataa gctaaagagg ctgaaagagg     1463

ccaatgcccc actggcagca tcttcacttc taaatgcata tcctgagcca tcggtgaaac     1523

taacagataa gcaagagaga tgttttgggg actcatttca ttcctaacac agcatgtgta     1583

tttccagtgc aattgtaggg gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtatgactaa     1643

agagagaatg tagatattgt gaagtacata ttaggaaaat atgggttgca tttggtcaag     1703

attttgaatg cttcctgaca atcaactcta atagtgctta aaaatcattg attgtcagct     1763

actaatgatg ttttcctata atataataaa tatttatgta gatgtgcatt tttgtgaaat     1823

gaaaacatgt aataaaaagt atatgttagg atacaaaaaa aaaaaaaaaa aaaaaaaaaa     1883

aaaaaaaaaa aaaaaaaaaa aaaaaa                                          1909


<210>  41
<211>  281
<212>  PRT
<213>  Homo sapiens

<400>  41

Met Gln Gln Pro Phe Asn Tyr Pro Tyr Pro Gln Ile Tyr Trp Val Asp 
1               5                   10                  15      


Ser Ser Ala Ser Ser Pro Trp Ala Pro Pro Gly Thr Val Leu Pro Cys 
            20                  25                  30          


Pro Thr Ser Val Pro Arg Arg Pro Gly Gln Arg Arg Pro Pro Pro Pro 
        35                  40                  45              


Pro Pro Pro Pro Pro Leu Pro Pro Pro Pro Pro Pro Pro Pro Leu Pro 
    50                  55                  60                  


Pro Leu Pro Leu Pro Pro Leu Lys Lys Arg Gly Asn His Ser Thr Gly 
65                  70                  75                  80  


Leu Cys Leu Leu Val Met Phe Phe Met Val Leu Val Ala Leu Val Gly 
                85                  90                  95      


Leu Gly Leu Gly Met Phe Gln Leu Phe His Leu Gln Lys Glu Leu Ala 
            100                 105                 110         


Glu Leu Arg Glu Ser Thr Ser Gln Met His Thr Ala Ser Ser Leu Glu 
        115                 120                 125             


Lys Gln Ile Gly His Pro Ser Pro Pro Pro Glu Lys Lys Glu Leu Arg 
    130                 135                 140                 


Lys Val Ala His Leu Thr Gly Lys Ser Asn Ser Arg Ser Met Pro Leu 
145                 150                 155                 160 


Glu Trp Glu Asp Thr Tyr Gly Ile Val Leu Leu Ser Gly Val Lys Tyr 
                165                 170                 175     


Lys Lys Gly Gly Leu Val Ile Asn Glu Thr Gly Leu Tyr Phe Val Tyr 
            180                 185                 190         


Ser Lys Val Tyr Phe Arg Gly Gln Ser Cys Asn Asn Leu Pro Leu Ser 
        195                 200                 205             


His Lys Val Tyr Met Arg Asn Ser Lys Tyr Pro Gln Asp Leu Val Met 
    210                 215                 220                 


Met Glu Gly Lys Met Met Ser Tyr Cys Thr Thr Gly Gln Met Trp Ala 
225                 230                 235                 240 


Arg Ser Ser Tyr Leu Gly Ala Val Phe Asn Leu Thr Ser Ala Asp His 
                245                 250                 255     


Leu Tyr Val Asn Val Ser Glu Leu Ser Leu Val Asn Phe Glu Glu Ser 
            260                 265                 270         


Gln Thr Phe Phe Gly Leu Tyr Lys Leu 
        275                 280     


<210>  42
<211>  43
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  42
taggcagtgg tttgacgtcc gcatgttggg aatagccacg cct                         43


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic


<220>
<221>  MISC_FEATURE
<222>  (5)..(9)
<223>  One or more of residues 5 through 9 are optionally absent

<400>  43

Arg Arg Arg Arg Arg Arg Arg Arg Arg 
1               5                   


<210>  44
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  44

Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln 
1               5                   10              


<210>  45
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  45

Ala Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 
1               5                   10          


<210>  46
<211>  34
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  46

Asp Ala Ala Thr Ala Thr Arg Gly Arg Ser Ala Ala Ser Arg Pro Thr 
1               5                   10                  15      


Glu Arg Pro Arg Ala Pro Ala Arg Ser Ala Ser Arg Pro Arg Arg Pro 
            20                  25                  30          


Val Glu 
        


<210>  47
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  47

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Leu Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  48
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  48

Pro Leu Ser Ser Ile Phe Ser Arg Ile Gly Asp Pro 
1               5                   10          


<210>  49
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  49

Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro 
1               5                   10                  15      


<210>  50
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  50

Ala Ala Val Leu Leu Pro Val Leu Leu Ala Ala Pro 
1               5                   10          


<210>  51
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  51

Val Thr Val Leu Ala Leu Gly Ala Leu Ala Gly Val Gly Val Gly 
1               5                   10                  15  


<210>  52
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  52

Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met Gly 
1               5                   10                  15      


Ala Trp Ser Gln Pro 
            20      


<210>  53
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  53

Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Leu Ile Asn Leu 
1               5                   10                  15      


Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 
            20                  25          


<210>  54
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  54

Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys 
1               5                   10                  15      


Leu Ala 
        


<210>  55
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  55

Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys 
1               5                   10                  15      


Lys Lys Arg Lys Val 
            20      


<210>  56
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  56

Lys Ala Phe Ala Lys Leu Ala Ala Arg Leu Tyr Arg Lys Ala Gly Cys 
1               5                   10                  15      


<210>  57
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  57

Lys Ala Phe Ala Lys Leu Ala Ala Arg Leu Tyr Arg Ala Ala Gly Cys 
1               5                   10                  15      


<210>  58
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  58

Ala Ala Phe Ala Lys Leu Ala Ala Arg Leu Tyr Arg Lys Ala Gly Cys 
1               5                   10                  15      


<210>  59
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  59

Lys Ala Phe Ala Ala Leu Ala Ala Arg Leu Tyr Arg Lys Ala Gly Cys 
1               5                   10                  15      


<210>  60
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  60

Lys Ala Phe Ala Lys Leu Ala Ala Gln Leu Tyr Arg Lys Ala Gly Cys 
1               5                   10                  15      


<210>  61
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  61

Ala Gly Gly Gly Gly Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 
1               5                   10                  15      


