SEQUENCE LISTING

<110>   NOVARTIS AG

<120>   DIAGNOSTIC AND THERAPEUTIC METHODS
        
<130>   P053675WO

<150>   GB 0918392.2
<151>   2009-10-20

<160>   10

<170>   SeqWin99, version 1.02

<210>   1
<211>   398
<212>   PRT
<213>   Streptococcus pyogenes

<400>   1
Met Lys Lys Arg Ile Leu Ser Ala Val Leu Val Ser Gly Val Thr Leu 
1               5                   10                  15      

Gly Ala Ala Thr Thr Val Gly Ala Glu Asp Leu Ser Thr Lys Ile Ala 
            20                  25                  30          

Lys Gln Asp Ser Ile Ile Ser Asn Leu Thr Thr Glu Gln Lys Ala Ala 
        35                  40                  45              

Gln Asn Gln Val Ser Ala Leu Gln Ala Gln Val Ser Ser Leu Gln Ser 
    50                  55                  60                  

Glu Gln Asp Lys Leu Thr Ala Arg Asn Thr Glu Leu Glu Ala Leu Ser 
65                  70                  75                  80  

Lys Arg Phe Glu Gln Glu Ile Lys Ala Leu Thr Ser Gln Ile Val Ala 
                85                  90                  95      

Arg Asn Glu Lys Leu Lys Asn Gln Ala Arg Ser Ala Tyr Lys Asn Asn 
            100                 105                 110         

Glu Thr Ser Gly Tyr Ile Asn Ala Leu Leu Asn Ser Lys Ser Ile Ser 
        115                 120                 125             

Asp Val Val Asn Arg Leu Val Ala Ile Asn Arg Ala Val Ser Ala Asn 
    130                 135                 140                 

Ala Lys Leu Leu Glu Gln Gln Lys Ala Asp Lys Val Ser Leu Glu Glu 
145                 150                 155                 160 

Lys Gln Ala Ala Asn Gln Thr Ala Ile Asn Thr Ile Ala Ala Asn Met 
                165                 170                 175     

Ala Met Ala Glu Glu Asn Gln Asn Thr Leu Arg Thr Gln Gln Ala Asn 
            180                 185                 190         

Leu Val Ala Ala Thr Ala Asn Leu Ala Leu Gln Leu Ala Ser Ala Thr 
        195                 200                 205             

Glu Asp Lys Ala Asn Leu Val Ala Gln Lys Glu Ala Ala Glu Lys Ala 
    210                 215                 220                 

Ala Ala Glu Ala Leu Ala Gln Glu Gln Ala Ala Lys Val Lys Ala Gln 
225                 230                 235                 240 

Glu Gln Ala Ala Gln Gln Ala Ala Ser Val Glu Ala Ala Lys Ser Ala 
                245                 250                 255     

Ile Thr Pro Ala Pro Gln Ala Thr Pro Ala Ala Gln Ser Ser Asn Ala 
            260                 265                 270         

Ile Glu Pro Ala Ala Leu Thr Ala Pro Ala Ala Pro Ser Ala Gly Pro 
        275                 280                 285             

Gln Thr Ser Tyr Asp Ser Ser Asn Thr Tyr Pro Val Gly Gln Cys Thr 
    290                 295                 300                 

Trp Gly Ala Lys Ser Leu Ala Pro Trp Ala Gly Asn Asn Trp Gly Asn 
305                 310                 315                 320 

Gly Gly Gln Trp Ala Tyr Ser Ala Gln Ala Ala Gly Tyr Arg Thr Gly 
                325                 330                 335     

Ser Thr Pro Met Val Gly Ala Ile Ala Val Trp Asn Asp Gly Gly Tyr 
            340                 345                 350         

Gly His Val Ala Val Val Val Glu Val Gln Ser Ala Ser Ser Ile Arg 
        355                 360                 365             

Val Met Glu Ser Asn Tyr Ser Gly Arg Gln Tyr Ile Ala Asp His Arg 
    370                 375                 380                 

Gly Trp Phe Asn Pro Thr Gly Val Thr Phe Ile Tyr Pro His 
385                 390                 395             

<210>   2
<211>   175
<212>   PRT
<213>   Streptococcus pyogenes

<400>   2
Ala Ala Ala Glu Ala Leu Ala Gln Glu Gln Ala Ala Lys Val Lys Ala 
1               5                   10                  15      

Gln Glu Gln Ala Ala Gln Gln Ala Ala Ser Val Glu Ala Ala Lys Ser 
            20                  25                  30          

Ala Ile Thr Pro Ala Pro Gln Ala Thr Pro Ala Ala Gln Ser Ser Asn 
        35                  40                  45              

Ala Ile Glu Pro Ala Ala Leu Thr Ala Pro Ala Ala Pro Ser Ala Gly 
    50                  55                  60                  

Pro Gln Thr Ser Tyr Asp Ser Ser Asn Thr Tyr Pro Val Gly Gln Cys 
65                  70                  75                  80  

Thr Trp Gly Ala Lys Ser Leu Ala Pro Trp Ala Gly Asn Asn Trp Gly 
                85                  90                  95      

Asn Gly Gly Gln Trp Ala Tyr Ser Ala Gln Ala Ala Gly Tyr Arg Thr 
            100                 105                 110         

Gly Ser Thr Pro Met Val Gly Ala Ile Ala Val Trp Asn Asp Gly Gly 
        115                 120                 125             

Tyr Gly His Val Ala Val Val Val Glu Val Gln Ser Ala Ser Ser Ile 
    130                 135                 140                 

Arg Val Met Glu Ser Asn Tyr Ser Gly Arg Gln Tyr Ile Ala Asp His 
145                 150                 155                 160 

Arg Gly Trp Phe Asn Pro Thr Gly Val Thr Phe Ile Tyr Pro His 
                165                 170                 175 

<210>   3
<211>   571
<212>   PRT
<213>   Streptococcus pyogenes

<400>   3
Met Ser Asn Lys Lys Thr Phe Lys Lys Tyr Ser Arg Val Ala Gly Leu 
1               5                   10                  15      

Leu Thr Ala Ala Leu Ile Ile Gly Asn Leu Val Thr Ala Asn Ala Glu 
            20                  25                  30          

Ser Asn Lys Gln Asn Thr Ala Ser Thr Glu Thr Thr Thr Thr Asn Glu 
        35                  40                  45              

Gln Pro Lys Pro Glu Ser Ser Glu Leu Thr Thr Glu Lys Ala Gly Gln 
    50                  55                  60                  

Lys Thr Asp Asp Met Leu Asn Ser Asn Asp Met Ile Lys Leu Ala Pro 
65                  70                  75                  80  

Lys Glu Met Pro Leu Glu Ser Ala Glu Lys Glu Glu Lys Lys Ser Glu 
                85                  90                  95      

Asp Lys Lys Lys Ser Glu Glu Asp His Thr Glu Glu Ile Asn Asp Lys 
            100                 105                 110         

Ile Tyr Ser Leu Asn Tyr Asn Glu Leu Glu Val Leu Ala Lys Asn Gly 
        115                 120                 125             

Glu Thr Ile Glu Asn Phe Val Pro Lys Glu Gly Val Lys Lys Ala Asp 
    130                 135                 140                 

Lys Phe Ile Val Ile Glu Arg Lys Lys Lys Asn Ile Asn Thr Thr Pro 
145                 150                 155                 160 

Val Asp Ile Ser Ile Ile Asp Ser Val Thr Asp Arg Thr Tyr Pro Ala 
                165                 170                 175     

Ala Leu Gln Leu Ala Asn Lys Gly Phe Thr Glu Asn Lys Pro Asp Ala 
            180                 185                 190         

Val Val Thr Lys Arg Asn Pro Gln Lys Ile His Ile Asp Leu Pro Gly 
        195                 200                 205             

Met Gly Asp Lys Ala Thr Val Glu Val Asn Asp Pro Thr Tyr Ala Asn 
    210                 215                 220                 

Val Ser Thr Ala Ile Asp Asn Leu Val Asn Gln Trp His Asp Asn Tyr 
225                 230                 235                 240 

Ser Gly Gly Asn Thr Leu Pro Ala Arg Thr Gln Tyr Thr Glu Ser Met 
                245                 250                 255     

Val Tyr Ser Lys Ser Gln Ile Glu Ala Ala Leu Asn Val Asn Ser Lys 
            260                 265                 270         

Ile Leu Asp Gly Thr Leu Gly Ile Asp Phe Lys Ser Ile Ser Lys Gly 
        275                 280                 285             

Glu Lys Lys Val Met Ile Ala Ala Tyr Lys Gln Ile Phe Tyr Thr Val 
    290                 295                 300                 

Ser Ala Asn Leu Pro Asn Asn Pro Ala Asp Val Phe Asp Lys Ser Val 
305                 310                 315                 320 

Thr Phe Lys Glu Leu Gln Arg Lys Gly Val Ser Asn Glu Ala Pro Pro 
                325                 330                 335     

Leu Phe Val Ser Asn Val Ala Tyr Gly Arg Thr Val Phe Val Lys Leu 
            340                 345                 350         

Glu Thr Ser Ser Lys Ser Asn Asp Val Glu Ala Ala Phe Ser Ala Ala 
        355                 360                 365             

Leu Lys Gly Thr Asp Val Lys Thr Asn Gly Lys Tyr Ser Asp Ile Leu 
    370                 375                 380                 

Glu Asn Ser Ser Phe Thr Ala Val Val Leu Gly Gly Asp Ala Ala Glu 
385                 390                 395                 400 

His Asn Lys Val Val Thr Lys Asp Phe Asp Val Ile Arg Asn Val Ile 
                405                 410                 415     

Lys Asp Asn Ala Thr Phe Ser Arg Lys Asn Pro Ala Tyr Pro Ile Ser 
            420                 425                 430         

Tyr Thr Ser Val Phe Leu Lys Asn Asn Lys Ile Ala Gly Val Asn Asn 
        435                 440                 445             

Arg Thr Glu Tyr Val Glu Thr Thr Ser Thr Glu Tyr Thr Ser Gly Lys 
    450                 455                 460                 

Ile Asn Leu Ser His Gln Gly Ala Tyr Val Ala Gln Tyr Glu Ile Leu 
465                 470                 475                 480 

Trp Asp Glu Ile Asn Tyr Asp Asp Lys Gly Lys Glu Val Ile Thr Lys 
                485                 490                 495     

Arg Arg Trp Asp Asn Asn Trp Tyr Ser Lys Thr Ser Pro Phe Ser Thr 
            500                 505                 510         

Val Ile Pro Leu Gly Ala Asn Ser Arg Asn Ile Arg Ile Met Ala Arg 
        515                 520                 525             

Glu Cys Thr Gly Leu Ala Trp Glu Trp Trp Arg Lys Val Ile Asp Glu 
    530                 535                 540                 

Arg Asp Val Lys Leu Ser Lys Glu Ile Asn Val Asn Ile Ser Gly Ser 
545                 550                 555                 560 

Thr Leu Ser Pro Tyr Gly Ser Ile Thr Tyr Lys 
                565                 570     

<210>   4
<211>   873
<212>   PRT
<213>   Streptococcus pyogenes

<400>   4
Met Asp Leu Glu Gln Thr Lys Pro Asn Gln Val Lys Gln Lys Ile Ala 
1               5                   10                  15      

Leu Thr Ser Thr Ile Ala Leu Leu Ser Ala Ser Val Gly Val Ser His 
            20                  25                  30          

Gln Val Lys Ala Asp Asp Arg Ala Ser Gly Glu Thr Lys Ala Ser Asn 
        35                  40                  45              

Thr His Asp Asp Ser Leu Pro Lys Pro Glu Thr Ile Gln Glu Ala Lys 
    50                  55                  60                  

Ala Thr Ile Asp Ala Val Glu Lys Thr Leu Ser Gln Gln Lys Ala Glu 
65                  70                  75                  80  

Leu Thr Glu Leu Ala Thr Ala Leu Thr Lys Thr Thr Ala Glu Ile Asn 
                85                  90                  95      

His Leu Lys Glu Gln Gln Asp Asn Glu Gln Lys Ala Leu Thr Ser Ala 
            100                 105                 110         

Gln Glu Ile Tyr Thr Asn Thr Leu Ala Ser Ser Glu Glu Thr Leu Leu 
        115                 120                 125             

Ala Gln Gly Ala Glu His Gln Arg Glu Leu Thr Ala Thr Glu Thr Glu 
    130                 135                 140                 

Leu His Asn Ala Gln Ala Asp Gln His Ser Lys Glu Thr Ala Leu Ser 
145                 150                 155                 160 

Glu Gln Lys Ala Ser Ile Ser Ala Glu Thr Thr Arg Ala Gln Asp Leu 
                165                 170                 175     

Val Glu Gln Val Lys Thr Ser Glu Gln Asn Ile Ala Lys Leu Asn Ala 
            180                 185                 190         

Met Ile Ser Asn Pro Asp Ala Ile Thr Lys Ala Ala Gln Thr Ala Asn 
        195                 200                 205             

Asp Asn Thr Lys Ala Leu Ser Ser Glu Leu Glu Lys Ala Lys Ala Asp 
    210                 215                 220                 

Leu Glu Asn Gln Lys Ala Lys Val Lys Lys Gln Leu Thr Glu Glu Leu 
225                 230                 235                 240 

Ala Ala Gln Lys Ala Ala Leu Ala Glu Lys Glu Ala Glu Leu Ser Arg 
                245                 250                 255     

Leu Lys Ser Ser Ala Pro Ser Thr Gln Asp Ser Ile Val Gly Asn Asn 
            260                 265                 270         

Thr Met Lys Ala Pro Gln Gly Tyr Pro Leu Glu Glu Leu Lys Lys Leu 
        275                 280                 285             

Glu Ala Ser Gly Tyr Ile Gly Ser Ala Ser Tyr Asn Asn Tyr Tyr Lys 
    290                 295                 300                 

Glu His Ala Asp Gln Ile Ile Ala Lys Ala Ser Pro Gly Asn Gln Leu 
305                 310                 315                 320 

Asn Gln Tyr Gln Asp Ile Pro Ala Asp Arg Asn Arg Phe Val Asp Pro 
                325                 330                 335     

Asp Asn Leu Thr Pro Glu Val Gln Asn Glu Leu Ala Gln Phe Ala Ala 
            340                 345                 350         

His Met Ile Asn Ser Val Arg Arg Gln Leu Gly Leu Pro Pro Val Thr 
        355                 360                 365             

Val Thr Ala Gly Ser Gln Glu Phe Ala Arg Leu Leu Ser Thr Ser Tyr 
    370                 375                 380                 

Lys Lys Thr His Gly Asn Thr Arg Pro Ser Phe Val Tyr Gly Gln Pro 
385                 390                 395                 400 

Gly Val Ser Gly His Tyr Gly Val Gly Pro His Asp Lys Thr Ile Ile 
                405                 410                 415     

Glu Asp Ser Ala Gly Ala Ser Gly Leu Ile Arg Asn Asp Asp Asn Met 
            420                 425                 430         

Tyr Glu Asn Ile Gly Ala Phe Asn Asp Val His Thr Val Asn Gly Ile 
        435                 440                 445             

Lys Arg Gly Ile Tyr Asp Ser Ile Lys Tyr Met Leu Phe Thr Asp His 
    450                 455                 460                 

Leu His Gly Asn Thr Tyr Gly His Ala Ile Asn Phe Leu Arg Val Asp 
465                 470                 475                 480 

Lys His Asn Pro Asn Ala Pro Val Tyr Leu Gly Phe Ser Thr Ser Asn 
                485                 490                 495     

Val Gly Ser Leu Asn Glu His Phe Val Met Phe Pro Glu Ser Asn Ile 
            500                 505                 510         

Ala Asn His Gln Arg Phe Asn Lys Thr Pro Ile Lys Ala Val Gly Ser 
        515                 520                 525             

Thr Lys Asp Tyr Ala Gln Arg Val Gly Thr Val Ser Asp Thr Ile Ala 
    530                 535                 540                 

Ala Ile Lys Gly Lys Val Ser Ser Leu Glu Asn Arg Leu Ser Ala Ile 
545                 550                 555                 560 

His Gln Glu Ala Asp Ile Met Ala Ala Gln Ala Lys Val Ser Gln Leu 
                565                 570                 575     

Gln Gly Lys Leu Ala Ser Thr Leu Lys Gln Ser Asp Ser Leu Asn Leu 
            580                 585                 590         

Gln Val Arg Gln Leu Asn Asp Thr Lys Gly Ser Leu Arg Thr Glu Leu 
        595                 600                 605             

Leu Ala Ala Lys Ala Lys Gln Ala Gln Leu Glu Ala Thr Arg Asp Gln 
    610                 615                 620                 

Ser Leu Ala Lys Leu Ala Ser Leu Lys Ala Ala Leu His Gln Thr Glu 
625                 630                 635                 640 

Ala Leu Ala Glu Gln Ala Ala Ala Arg Val Thr Ala Leu Val Ala Lys 
                645                 650                 655     

Lys Ala His Leu Gln Tyr Leu Arg Asp Phe Lys Leu Asn Pro Asn Arg 
            660                 665                 670         

Leu Gln Val Ile Arg Glu Arg Ile Asp Asn Thr Lys Gln Asp Leu Ala 
        675                 680                 685             

Lys Thr Thr Ser Ser Leu Leu Asn Ala Gln Glu Ala Leu Ala Ala Leu 
    690                 695                 700                 

Gln Ala Lys Gln Ser Ser Leu Glu Ala Thr Ile Ala Thr Thr Glu His 
705                 710                 715                 720 

Gln Leu Thr Leu Leu Lys Thr Leu Ala Asn Glu Lys Glu Tyr Arg His 
                725                 730                 735     

Leu Asp Glu Asp Ile Ala Thr Val Pro Asp Leu Gln Val Ala Pro Pro 
            740                 745                 750         

Leu Thr Gly Val Lys Pro Leu Ser Tyr Ser Lys Ile Asp Thr Thr Pro 
        755                 760                 765             

Leu Val Gln Glu Met Val Lys Glu Thr Lys Gln Leu Leu Glu Ala Ser 
    770                 775                 780                 

Ala Arg Leu Ala Ala Glu Asn Thr Ser Leu Val Ala Glu Ala Leu Val 
785                 790                 795                 800 

Gly Gln Thr Ser Glu Met Val Ala Ser Asn Ala Ile Val Ser Lys Ile 
                805                 810                 815     

Thr Ser Ser Ile Thr Gln Pro Ser Ser Lys Thr Ser Tyr Gly Ser Gly 
            820                 825                 830         

Ser Ser Thr Thr Ser Asn Leu Ile Ser Asp Val Asp Glu Ser Thr Gln 
        835                 840                 845             

Arg Ala Leu Lys Ala Gly Val Val Met Leu Ala Ala Val Gly Leu Thr 
    850                 855                 860                 

Gly Phe Arg Phe Arg Lys Glu Ser Lys 
865                 870             

<210>   5
<211>   1647
<212>   PRT
<213>   Streptococcus pyogenes

<400>   5
Met Glu Lys Lys Gln Arg Phe Ser Leu Arg Lys Tyr Lys Ser Gly Thr 
1               5                   10                  15      

Phe Ser Val Leu Ile Gly Ser Val Phe Leu Val Met Thr Thr Thr Val 
            20                  25                  30          

Ala Ala Asp Glu Leu Ser Thr Met Ser Glu Pro Thr Ile Thr Asn His 
        35                  40                  45              

Ala Gln Gln Gln Ala Gln His Leu Thr Asn Thr Glu Leu Ser Ser Ala 
    50                  55                  60                  

Glu Ser Lys Ser Gln Asp Thr Ser Gln Ile Thr Leu Lys Thr Asn Arg 
65                  70                  75                  80  

Glu Lys Glu Gln Ser Gln Asp Leu Val Ser Glu Pro Thr Thr Thr Glu 
                85                  90                  95      

Leu Ala Asp Thr Asp Ala Ala Ser Met Ala Asn Thr Gly Ser Asp Ala 
            100                 105                 110         

Thr Gln Lys Ser Ala Ser Leu Pro Pro Val Asn Thr Asp Val His Asp 
        115                 120                 125             

Trp Val Lys Thr Lys Gly Ala Trp Asp Lys Gly Tyr Lys Gly Gln Gly 
    130                 135                 140                 

Lys Val Val Ala Val Ile Asp Thr Gly Ile Asp Pro Ala His Gln Ser 
145                 150                 155                 160 

Met Arg Ile Ser Asp Val Ser Thr Ala Lys Val Lys Ser Lys Glu Asp 
                165                 170                 175     

Met Leu Ala Arg Gln Lys Ala Ala Gly Ile Asn Tyr Gly Ser Trp Ile 
            180                 185                 190         

Asn Asp Lys Val Val Phe Ala His Asn Tyr Val Glu Asn Ser Asp Asn 
        195                 200                 205             

Ile Lys Glu Asn Gln Phe Glu Asp Phe Asp Glu Asp Trp Glu Asn Phe 
    210                 215                 220                 

Glu Phe Asp Ala Glu Ala Glu Pro Lys Ala Ile Lys Lys His Lys Ile 
225                 230                 235                 240 

Tyr Arg Pro Gln Ser Thr Gln Ala Pro Lys Glu Thr Val Ile Lys Thr 
                245                 250                 255     

Glu Glu Thr Asp Gly Ser His Asp Ile Asp Trp Thr Gln Thr Asp Asp 
            260                 265                 270         

Asp Thr Lys Tyr Glu Ser His Gly Met His Val Thr Gly Ile Val Ala 
        275                 280                 285             

Gly Asn Ser Lys Glu Ala Ala Ala Thr Gly Glu Arg Phe Leu Gly Ile 
    290                 295                 300                 

Ala Pro Glu Ala Gln Val Met Phe Met Arg Val Phe Ala Asn Asp Ile 
305                 310                 315                 320 

Met Gly Ser Ala Glu Ser Leu Phe Ile Lys Ala Ile Glu Asp Ala Val 
                325                 330                 335     

Ala Leu Gly Ala Asp Val Ile Asn Leu Ser Leu Gly Thr Ala Asn Gly 
            340                 345                 350         

Ala Gln Leu Ser Gly Ser Lys Pro Leu Met Glu Ala Ile Glu Lys Ala 
        355                 360                 365             

Lys Lys Ala Gly Val Ser Val Val Val Ala Ala Gly Asn Glu Arg Val 
    370                 375                 380                 

Tyr Gly Ser Asp His Asp Asp Pro Leu Ala Thr Asn Pro Asp Tyr Gly 
385                 390                 395                 400 

Leu Val Gly Ser Pro Ser Thr Gly Arg Thr Pro Thr Ser Val Ala Ala 
                405                 410                 415     

Ile Asn Ser Lys Trp Val Ile Gln Arg Leu Met Thr Val Lys Glu Leu 
            420                 425                 430         

Glu Asn Arg Ala Asp Leu Asn His Gly Lys Ala Ile Tyr Ser Glu Ser 
        435                 440                 445             

Val Asp Phe Lys Asp Ile Lys Asp Ser Leu Gly Tyr Asp Lys Ser His 
    450                 455                 460                 

Gln Phe Ala Tyr Val Lys Glu Ser Thr Asp Ala Gly Tyr Asn Ala Gln 
465                 470                 475                 480 

Asp Val Lys Gly Lys Ile Ala Leu Ile Glu Arg Asp Pro Asn Lys Thr 
                485                 490                 495     

Tyr Asp Glu Met Ile Ala Leu Ala Lys Lys His Gly Ala Leu Gly Val 
            500                 505                 510         

Leu Ile Phe Asn Asn Lys Pro Gly Gln Ser Asn Arg Ser Met Arg Leu 
        515                 520                 525             

Thr Ala Asn Gly Met Gly Ile Pro Ser Ala Phe Ile Ser His Glu Phe 
    530                 535                 540                 

Gly Lys Ala Met Ser Gln Leu Asn Gly Asn Gly Thr Gly Ser Leu Glu 
545                 550                 555                 560 

Phe Asp Ser Val Val Ser Lys Ala Pro Ser Gln Lys Gly Asn Glu Met 
                565                 570                 575     

Asn His Phe Ser Asn Trp Gly Leu Thr Ser Asp Gly Tyr Leu Lys Pro 
            580                 585                 590         

Asp Ile Thr Ala Pro Gly Gly Asp Ile Tyr Ser Thr Tyr Asn Asp Asn 
        595                 600                 605             

His Tyr Gly Ser Gln Thr Gly Thr Ser Met Ala Ser Pro Gln Ile Ala 
    610                 615                 620                 

Gly Ala Ser Leu Leu Val Lys Gln Tyr Leu Glu Lys Thr Gln Pro Asn 
625                 630                 635                 640 

Leu Pro Lys Glu Lys Ile Ala Asp Ile Val Lys Asn Leu Leu Met Ser 
                645                 650                 655     

Asn Ala Gln Ile His Val Asn Pro Glu Thr Lys Thr Thr Thr Ser Pro 
            660                 665                 670         

Arg Gln Gln Gly Ala Gly Leu Leu Asn Ile Asp Gly Ala Val Thr Ser 
        675                 680                 685             

Gly Leu Tyr Val Thr Gly Lys Asp Asn Tyr Gly Ser Ile Ser Leu Gly 
    690                 695                 700                 

Asn Ile Thr Asp Thr Met Thr Phe Asp Val Thr Val His Asn Leu Ser 
705                 710                 715                 720 

Asn Lys Asp Lys Thr Leu Arg Tyr Asp Thr Glu Leu Leu Thr Asp His 
                725                 730                 735     

Val Asp Pro Gln Lys Gly Arg Phe Thr Leu Thr Ser His Ser Leu Lys 
            740                 745                 750         

Thr Tyr Gln Gly Gly Glu Val Thr Val Pro Ala Asn Gly Lys Val Thr 
        755                 760                 765             

Val Arg Val Thr Met Asp Val Ser Gln Phe Thr Lys Glu Leu Thr Lys 
    770                 775                 780                 

Gln Met Pro Asn Gly Tyr Tyr Leu Glu Gly Phe Val Arg Phe Arg Asp 
785                 790                 795                 800 

Ser Gln Asp Asp Gln Leu Asn Arg Val Asn Ile Pro Phe Val Gly Phe 
                805                 810                 815     

Lys Gly Gln Phe Glu Asn Leu Ala Val Ala Glu Glu Ser Ile Tyr Arg 
            820                 825                 830         

Leu Lys Ser Gln Gly Lys Thr Gly Phe Tyr Phe Asp Glu Ser Gly Pro 
        835                 840                 845             

Lys Asp Asp Ile Tyr Val Gly Lys His Phe Thr Gly Leu Val Thr Leu 
    850                 855                 860                 

Gly Ser Glu Thr Asn Val Ser Thr Lys Thr Ile Ser Asp Asn Gly Leu 
865                 870                 875                 880 

His Thr Leu Gly Thr Phe Lys Asn Ala Asp Gly Lys Phe Ile Leu Glu 
                885                 890                 895     

Lys Asn Ala Gln Gly Asn Pro Val Leu Ala Ile Ser Pro Asn Gly Asp 
            900                 905                 910         

Asn Asn Gln Asp Phe Ala Ala Phe Lys Gly Val Phe Leu Arg Lys Tyr 
        915                 920                 925             

Gln Gly Leu Lys Ala Ser Val Tyr His Ala Ser Asp Lys Glu His Lys 
    930                 935                 940                 

Asn Pro Leu Trp Val Ser Pro Glu Ser Phe Lys Gly Asp Lys Asn Phe 
945                 950                 955                 960 

Asn Ser Asp Ile Arg Phe Ala Lys Ser Thr Thr Leu Leu Gly Thr Ala 
                965                 970                 975     

Phe Ser Gly Lys Ser Leu Thr Gly Ala Glu Leu Pro Asp Gly His Tyr 
            980                 985                 990         

His Tyr Val Val Ser Tyr Tyr Pro Asp Val Val Gly Ala Lys Arg Gln 
        995                 1000                1005            

Glu Met Thr Phe Asp Met Ile Leu Asp Arg Gln Lys Pro Val Leu Ser 
    1010                1015                1020                

Gln Ala Thr Phe Asp Pro Glu Thr Asn Arg Phe Lys Pro Glu Pro Leu 
1025                1030                1035                1040

Lys Asp Arg Gly Leu Ala Gly Val Arg Lys Asp Ser Val Phe Tyr Leu 
                1045                1050                1055    

Glu Arg Lys Asp Asn Lys Pro Tyr Thr Val Thr Ile Asn Asp Ser Tyr 
            1060                1065                1070        

Lys Tyr Val Ser Val Glu Asp Asn Lys Thr Phe Val Glu Arg Gln Ala 
        1075                1080                1085            

Asp Gly Ser Phe Ile Leu Pro Leu Asp Lys Ala Lys Leu Gly Asp Phe 
    1090                1095                1100                

Tyr Tyr Met Val Glu Asp Phe Ala Gly Asn Val Ala Ile Ala Lys Leu 
1105                1110                1115                1120

Gly Asp His Leu Pro Gln Thr Leu Gly Lys Thr Pro Ile Lys Leu Lys 
                1125                1130                1135    

Leu Thr Asp Gly Asn Tyr Gln Thr Lys Glu Thr Leu Lys Asp Asn Leu 
            1140                1145                1150        

Glu Met Thr Gln Ser Asp Thr Gly Leu Val Thr Asn Gln Ala Gln Leu 
        1155                1160                1165            

Ala Val Val His Arg Asn Gln Pro Gln Ser Gln Leu Thr Lys Met Asn 
    1170                1175                1180                

Gln Asp Phe Phe Ile Ser Pro Asn Glu Asp Gly Asn Lys Asp Phe Val 
1185                1190                1195                1200

Ala Phe Lys Gly Leu Lys Asn Asn Val Tyr Asn Asp Leu Thr Val Asn 
                1205                1210                1215    

Val Tyr Ala Lys Asp Asp His Gln Lys Gln Thr Pro Ile Trp Ser Ser 
            1220                1225                1230        

Gln Ala Gly Ala Ser Val Ser Ala Ile Glu Ser Thr Ala Trp Tyr Gly 
        1235                1240                1245            

Ile Thr Ala Arg Gly Ser Lys Val Met Pro Gly Asp Tyr Gln Tyr Val 
    1250                1255                1260                

Val Thr Tyr Arg Asp Glu His Gly Lys Glu His Gln Lys Gln Tyr Thr 
1265                1270                1275                1280

Ile Ser Val Asn Asp Lys Lys Pro Met Ile Thr Gln Gly Arg Phe Asp 
                1285                1290                1295    

Thr Ile Asn Gly Val Asp His Phe Thr Pro Asp Lys Thr Lys Ala Leu 
            1300                1305                1310        

Asp Ser Ser Gly Ile Val Arg Glu Glu Val Phe Tyr Leu Ala Lys Lys 
        1315                1320                1325            

Asn Gly Arg Lys Phe Asp Val Thr Glu Gly Lys Asp Gly Ile Thr Val 
    1330                1335                1340                

Ser Asp Asn Lys Val Tyr Ile Pro Lys Asn Pro Asp Gly Ser Tyr Thr 
1345                1350                1355                1360

Ile Ser Lys Arg Asp Gly Val Thr Leu Ser Asp Tyr Tyr Tyr Leu Val 
                1365                1370                1375    

Glu Asp Arg Ala Gly Asn Val Ser Phe Ala Thr Leu Arg Asp Leu Lys 
            1380                1385                1390        

Ala Val Gly Lys Asp Lys Ala Val Val Asn Phe Gly Leu Asp Leu Pro 
        1395                1400                1405            

Val Pro Glu Asp Lys Gln Ile Val Asn Phe Thr Tyr Leu Val Arg Asp 
    1410                1415                1420                

Ala Asp Gly Lys Pro Ile Glu Asn Leu Glu Tyr Tyr Asn Asn Ser Gly 
1425                1430                1435                1440

Asn Ser Leu Ile Leu Pro Tyr Gly Lys Tyr Thr Val Glu Leu Leu Thr 
                1445                1450                1455    

Tyr Asp Thr Asn Ala Ala Lys Leu Glu Ser Asp Lys Ile Val Ser Phe 
            1460                1465                1470        

Thr Leu Ser Ala Asp Asn Asn Phe Gln Gln Val Thr Phe Lys Ile Thr 
        1475                1480                1485            

Met Leu Ala Thr Ser Gln Ile Thr Ala His Phe Asp His Leu Leu Pro 
    1490                1495                1500                

Glu Gly Ser Arg Val Ser Leu Lys Thr Ala Gln Asp Gln Leu Ile Pro 
1505                1510                1515                1520

Leu Glu Gln Ser Leu Tyr Val Pro Lys Ala Tyr Gly Lys Thr Val Gln 
                1525                1530                1535    

Glu Gly Thr Tyr Glu Val Val Val Ser Leu Pro Lys Gly Tyr Arg Ile 
            1540                1545                1550        

Glu Gly Asn Thr Lys Val Asn Thr Leu Pro Asn Glu Val His Glu Leu 
        1555                1560                1565            

Ser Leu Arg Leu Val Lys Val Gly Asp Ala Ser Asp Ser Thr Gly Asp 
    1570                1575                1580                

His Lys Val Met Ser Lys Asn Asn Ser Gln Ala Leu Thr Ala Ser Ala 
1585                1590                1595                1600

Thr Pro Thr Lys Ser Thr Thr Ser Ala Thr Ala Lys Ala Leu Pro Ser 
                1605                1610                1615    

Thr Gly Glu Lys Met Gly Leu Lys Leu Arg Ile Val Gly Leu Val Leu 
            1620                1625                1630        

Leu Gly Leu Thr Cys Val Phe Ser Arg Lys Lys Ser Thr Lys Asp 
        1635                1640                1645        

<210>   6
<211>   503
<212>   PRT
<213>   Streptococcus pyogenes

<400>   6
Met Asn Lys Asn Lys Leu Leu Arg Val Ala Met Leu Leu Ser Leu Leu 
1               5                   10                  15      

Ala Pro Thr Ala Glu Ser Met Thr Val Leu Ala Gln Asp Val Met Leu 
            20                  25                  30          

Glu Thr His Lys Ala Thr Thr Asn Glu Thr Ser Asp Ser Ser Ser Lys 
        35                  40                  45              

Glu Glu Asn Asn Lys Asn Ala Ala Pro Thr Thr Ser Asp Lys Thr Asp 
    50                  55                  60                  

Gln Gly Pro Leu Asp Ala Ser Ala Glu Thr Asn Ser Asn Ser Leu Val 
65                  70                  75                  80  

Asn Ala Asp Asp Lys Lys Arg Ser Asp Ser Ser Gln Ser Ala Ile Gly 
                85                  90                  95      

Ser Ser Asp Asn Lys Ala Glu Ala Glu Asn Gln Val Asp Asp Lys Ser 
            100                 105                 110         

Thr Asp His Ser Lys Ser Thr Asp His Ser Lys Pro Thr Asp Gln Pro 
        115                 120                 125             

Lys Pro Ser Pro Ser Lys Val Asp Thr Ala Pro Ala Ser Ser Leu Ser 
    130                 135                 140                 

Lys Gln Leu Pro Glu Ala Arg Thr Pro Ile Gln Ser Leu Ser Pro Tyr 
145                 150                 155                 160 

Val Ser Asp Leu Asp Leu Ser Glu Ile Asp Ile Pro Ser Val Asn Thr 
                165                 170                 175     

Tyr Ala Ala Tyr Val Glu His Trp Ser Gly Lys Asn Ala Tyr Thr His 
            180                 185                 190         

His Leu Leu Ser Arg Arg Tyr Gly Ile Lys Ala Asp Gln Ile Asp Ser 
        195                 200                 205             

Tyr Leu Lys Ser Thr Gly Ile Ala Tyr Asp Ser Thr Arg Ile Asn Gly 
    210                 215                 220                 

Glu Lys Leu Leu Gln Trp Glu Lys Lys Ser Gly Leu Asp Val Arg Ala 
225                 230                 235                 240 

Ile Val Ala Ile Ala Met Ser Glu Ser Ser Leu Gly Thr Gln Gly Ile 
                245                 250                 255     

Ala Thr Leu Leu Gly Ala Asn Met Phe Gly Tyr Ala Ala Phe Asp Leu 
            260                 265                 270         

Asp Pro Thr Gln Ala Ser Lys Phe Asn Asp Asp Ser Ala Ile Val Lys 
        275                 280                 285             

Met Thr Gln Asp Thr Ile Ile Lys Asn Lys Asn Ser Asn Phe Ala Leu 
    290                 295                 300                 

Gln Asp Leu Lys Ala Ala Lys Phe Ser Arg Gly Gln Leu Asn Phe Ala 
305                 310                 315                 320 

Ser Asp Gly Gly Val Tyr Phe Thr Asp Thr Thr Gly Ser Gly Lys Arg 
                325                 330                 335     

Arg Ala Gln Ile Met Glu Asp Leu Asp Lys Trp Ile Asp Asp His Gly 
            340                 345                 350         

Gly Thr Pro Ala Ile Pro Ala Glu Leu Lys Val Gln Ser Ser Ala Ser 
        355                 360                 365             

Phe Ala Ser Val Pro Ala Gly Tyr Lys Leu Ser Lys Ser Tyr Asp Val 
    370                 375                 380                 

Leu Gly Tyr Gln Ala Ser Ser Tyr Ala Trp Gly Gln Cys Thr Trp Tyr 
385                 390                 395                 400 

Val Tyr Asn Arg Ala Lys Glu Leu Gly Tyr Gln Phe Asp Pro Phe Met 
                405                 410                 415     

Gly Asn Gly Gly Asp Trp Lys Tyr Lys Val Gly Tyr Ala Leu Ser Lys 
            420                 425                 430         

Thr Pro Lys Val Gly Tyr Ala Ile Ser Phe Ala Pro Gly Gln Ala Gly 
        435                 440                 445             

Ala Asp Gly Thr Tyr Gly His Val Ser Ile Val Glu Asp Val Arg Lys 
    450                 455                 460                 

Asp Gly Ser Ile Leu Ile Ser Glu Ser Asn Cys Ile Gly Leu Gly Lys 
465                 470                 475                 480 

Ile Ser Tyr Arg Thr Phe Thr Ala Gln Gln Ala Glu Gln Leu Thr Tyr 
                485                 490                 495     

Val Ile Gly Lys Ser Lys Asn 
            500             

<210>   7
<211>   995
<212>   PRT
<213>   Streptococcus pyogenes

<400>   7
Met Asp Lys His Leu Leu Val Lys Arg Thr Leu Gly Cys Val Cys Ala 
1               5                   10                  15      

Ala Thr Leu Met Gly Ala Ala Leu Ala Thr His His Asp Ser Leu Asn 
            20                  25                  30          

Thr Val Lys Ala Glu Glu Lys Thr Val Gln Val Gln Lys Gly Leu Pro 
        35                  40                  45              

Ser Ile Asp Ser Leu His Tyr Leu Ser Glu Asn Ser Lys Lys Glu Phe 
    50                  55                  60                  

Lys Glu Glu Leu Ser Lys Ala Gly Gln Glu Ser Gln Lys Val Lys Glu 
65                  70                  75                  80  

Ile Leu Ala Lys Ala Gln Gln Ala Asp Lys Gln Ala Gln Glu Leu Ala 
                85                  90                  95      

Lys Met Lys Ile Pro Glu Lys Ile Pro Met Lys Pro Leu His Gly Ser 
            100                 105                 110         

Leu Tyr Gly Gly Tyr Phe Arg Thr Trp His Asp Lys Thr Ser Asp Pro 
        115                 120                 125             

Thr Glu Lys Asp Lys Val Asn Ser Met Gly Glu Leu Pro Lys Glu Val 
    130                 135                 140                 

Asp Leu Ala Phe Ile Phe His Asp Trp Thr Lys Asp Tyr Ser Leu Phe 
145                 150                 155                 160 

Trp Lys Glu Leu Ala Thr Lys His Val Pro Lys Leu Asn Lys Gln Gly 
                165                 170                 175     

Thr Arg Val Ile Arg Thr Ile Pro Trp Arg Phe Leu Ala Gly Gly Asp 
            180                 185                 190         

Asn Ser Gly Ile Ala Glu Asp Thr Ser Lys Tyr Pro Asn Thr Pro Glu 
        195                 200                 205             

Gly Asn Lys Ala Leu Ala Lys Ala Ile Val Asp Glu Tyr Val Tyr Lys 
    210                 215                 220                 

Tyr Asn Leu Asp Gly Leu Asp Val Asp Val Glu His Asp Ser Ile Pro 
225                 230                 235                 240 

Lys Val Asp Lys Lys Glu Asp Thr Ala Gly Val Glu Arg Ser Ile Gln 
                245                 250                 255     

Val Phe Glu Glu Ile Gly Lys Leu Ile Gly Pro Lys Gly Val Asp Lys 
            260                 265                 270         

Ser Arg Leu Phe Ile Met Asp Ser Thr Tyr Met Ala Asp Lys Asn Pro 
        275                 280                 285             

Leu Ile Glu Arg Gly Ala Pro Tyr Ile Asn Leu Leu Leu Val Gln Val 
    290                 295                 300                 

Tyr Gly Ser Gln Gly Glu Lys Gly Gly Trp Glu Pro Val Ser Asn Arg 
305                 310                 315                 320 

Pro Glu Lys Thr Met Glu Glu Arg Trp Gln Gly Tyr Ser Lys Tyr Ile 
                325                 330                 335     

Arg Pro Glu Gln Tyr Met Ile Gly Phe Ser Phe Tyr Glu Glu Asn Ala 
            340                 345                 350         

Gln Glu Gly Asn Leu Trp Tyr Asp Ile Asn Ser Arg Lys Asp Glu Asp 
        355                 360                 365             

Lys Ala Asn Gly Ile Asn Thr Asp Ile Thr Gly Thr Arg Ala Glu Arg 
    370                 375                 380                 

Tyr Ala Arg Trp Gln Pro Lys Thr Gly Gly Val Lys Gly Gly Ile Phe 
385                 390                 395                 400 

Ser Tyr Ala Ile Asp Arg Asp Gly Val Ala His Gln Pro Lys Lys Tyr 
                405                 410                 415     

Ala Lys Gln Lys Glu Phe Lys Asp Ala Thr Asp Asn Ile Phe His Ser 
            420                 425                 430         

Asp Tyr Ser Val Ser Lys Ala Leu Lys Thr Val Met Leu Lys Asp Lys 
        435                 440                 445             

Ser Tyr Asp Leu Ile Asp Glu Lys Asp Phe Pro Asp Lys Ala Leu Arg 
    450                 455                 460                 

Glu Ala Val Met Ala Gln Val Gly Thr Arg Lys Gly Asp Leu Glu Arg 
465                 470                 475                 480 

Phe Asn Gly Thr Leu Arg Leu Asp Asn Pro Ala Ile Gln Ser Leu Glu 
                485                 490                 495     

Gly Leu Asn Lys Phe Lys Lys Leu Ala Gln Leu Asp Leu Ile Gly Leu 
            500                 505                 510         

Ser Arg Ile Thr Lys Leu Asp Arg Ser Val Leu Pro Ala Asn Met Lys 
        515                 520                 525             

Pro Gly Lys Asp Thr Leu Glu Thr Val Leu Glu Thr Tyr Lys Lys Asp 
    530                 535                 540                 

Asn Lys Glu Glu Pro Ala Thr Ile Pro Pro Val Ser Leu Lys Val Ser 
545                 550                 555                 560 

Gly Leu Thr Gly Leu Lys Glu Leu Asp Leu Ser Gly Phe Asp Arg Glu 
                565                 570                 575     

Thr Leu Ala Gly Leu Asp Ala Ala Thr Leu Thr Ser Leu Glu Lys Val 
            580                 585                 590         

Asp Ile Ser Gly Asn Lys Leu Asp Leu Ala Pro Gly Thr Glu Asn Arg 
        595                 600                 605             

Gln Ile Phe Asp Thr Met Leu Ser Thr Ile Ser Asn His Val Gly Ser 
    610                 615                 620                 

Asn Glu Gln Thr Val Lys Phe Asp Lys Gln Lys Pro Thr Gly His Tyr 
625                 630                 635                 640 

Pro Asp Thr Tyr Gly Lys Thr Ser Leu Arg Leu Pro Val Ala Asn Glu 
                645                 650                 655     

Lys Val Asp Leu Gln Ser Gln Leu Leu Phe Gly Thr Val Thr Asn Gln 
            660                 665                 670         

Gly Thr Leu Ile Asn Ser Glu Ala Asp Tyr Lys Ala Tyr Gln Asn His 
        675                 680                 685             

Lys Ile Ala Gly Arg Ser Phe Val Asp Ser Asn Tyr His Tyr Asn Asn 
    690                 695                 700                 

Phe Lys Val Ser Tyr Glu Asn Tyr Thr Val Lys Val Thr Asp Ser Thr 
705                 710                 715                 720 

Leu Gly Thr Thr Thr Asp Lys Thr Leu Ala Thr Asp Lys Glu Glu Thr 
                725                 730                 735     

Tyr Lys Val Asp Phe Phe Ser Pro Ala Asp Lys Thr Lys Ala Val His 
            740                 745                 750         

Thr Ala Lys Val Ile Val Gly Asp Glu Lys Thr Met Met Val Asn Leu 
        755                 760                 765             

Ala Glu Gly Ala Thr Val Ile Gly Gly Ser Ala Asp Pro Val Asn Ala 
    770                 775                 780                 

Arg Lys Val Phe Asp Gly Gln Leu Gly Ser Glu Thr Asp Asn Ile Ser 
785                 790                 795                 800 

Leu Gly Trp Asp Ser Lys Gln Ser Ile Ile Phe Lys Leu Lys Glu Asp 
                805                 810                 815     

Gly Leu Ile Lys His Trp Arg Phe Phe Asn Asp Ser Ala Arg Asn Pro 
            820                 825                 830         

Glu Thr Thr Asn Lys Pro Ile Gln Glu Ala Ser Leu Gln Ile Phe Asn 
        835                 840                 845             

Ile Lys Asp Tyr Asn Leu Asp Asn Leu Leu Glu Asn Pro Asn Lys Phe 
    850                 855                 860                 

Asp Asp Glu Lys Tyr Trp Ile Thr Val Asp Thr Tyr Ser Ala Gln Gly 
865                 870                 875                 880 

Glu Arg Ala Thr Ala Phe Ser Asn Thr Leu Asn Asn Ile Thr Ser Lys 
                885                 890                 895     

Tyr Trp Arg Val Val Phe Asp Thr Lys Gly Asp Arg Tyr Ser Ser Pro 
            900                 905                 910         

Val Val Pro Glu Leu Gln Ile Leu Gly Tyr Pro Leu Pro Asn Ala Asp 
        915                 920                 925             

Thr Ile Met Lys Thr Val Thr Thr Ala Lys Glu Leu Ser Gln Gln Lys 
    930                 935                 940                 

Asp Lys Phe Ser Gln Lys Met Leu Asp Glu Leu Lys Ile Lys Glu Met 
945                 950                 955                 960 

Ala Leu Glu Thr Ser Leu Asn Ser Lys Ile Phe Asp Val Thr Ala Ile 
                965                 970                 975     

Asn Ala Asn Ala Gly Val Leu Lys Asp Cys Ile Glu Lys Arg Gln Leu 
            980                 985                 990         

Leu Lys Lys 
        995 

<210>   8
<211>   221
<212>   PRT
<213>   Streptococcus pyogenes

<400>   8
Gln Gln Asp Pro Asp Pro Ser Gln Leu His Arg Ser Ser Leu Val Lys 
1               5                   10                  15      

Asn Leu Gln Asn Ile Tyr Phe Leu Tyr Glu Gly Asp Pro Val Thr His 
            20                  25                  30          

Glu Asn Val Lys Ser Val Asp Gln Leu Leu Ser His Asp Leu Ile Tyr 
        35                  40                  45              

Asn Val Ser Gly Pro Asn Tyr Asp Lys Leu Lys Thr Glu Leu Lys Asn 
    50                  55                  60                  

Gln Glu Met Ala Thr Leu Phe Lys Asp Lys Asn Val Asp Ile Tyr Gly 
65                  70                  75                  80  

Val Glu Tyr Tyr His Leu Cys Tyr Leu Cys Glu Asn Ala Glu Arg Ser 
                85                  90                  95      

Ala Cys Ile Tyr Gly Gly Val Thr Asn His Glu Gly Asn His Leu Glu 
            100                 105                 110         

Ile Pro Lys Lys Ile Val Val Lys Val Ser Ile Asp Gly Ile Gln Ser 
        115                 120                 125             

Leu Ser Phe Asp Ile Glu Thr Asn Lys Lys Met Val Thr Ala Gln Glu 
    130                 135                 140                 

Leu Asp Tyr Lys Val Arg Lys Tyr Leu Thr Asp Asn Lys Gln Leu Tyr 
145                 150                 155                 160 

Thr Asn Gly Pro Ser Lys Tyr Glu Thr Gly Tyr Ile Lys Phe Ile Pro 
                165                 170                 175     

Lys Asn Lys Glu Ser Phe Trp Phe Asp Phe Phe Pro Glu Pro Glu Phe 
            180                 185                 190         

Thr Gln Ser Lys Tyr Leu Met Ile Tyr Lys Asp Asn Glu Thr Leu Asp 
        195                 200                 205             

Ser Asn Thr Ser Gln Ile Glu Val Tyr Leu Thr Thr Lys 
    210                 215                 220     

<210>   9
<211>   865
<212>   PRT
<213>   Streptococcus pyogenes

<400>   9
Ala Asp Glu Leu Ser Thr Met Ser Glu Pro Thr Ile Thr Asn His Ala 
1               5                   10                  15      

Gln Gln Gln Ala Gln His Leu Thr Asn Thr Glu Leu Ser Ser Ala Glu 
            20                  25                  30          

Ser Lys Ser Gln Asp Thr Ser Gln Ile Thr Leu Lys Thr Asn Arg Glu 
        35                  40                  45              

Lys Glu Gln Ser Gln Asp Leu Val Ser Glu Pro Thr Thr Thr Glu Leu 
    50                  55                  60                  

Ala Asp Thr Asp Ala Ala Ser Met Ala Asn Thr Gly Ser Asp Ala Thr 
65                  70                  75                  80  

Gln Lys Ser Ala Ser Leu Pro Pro Val Asn Thr Asp Val His Asp Trp 
                85                  90                  95      

Val Lys Thr Lys Gly Ala Trp Asp Lys Gly Tyr Lys Gly Gln Gly Lys 
            100                 105                 110         

Val Val Ala Val Ile Asp Thr Gly Ile Asp Pro Ala His Gln Ser Met 
        115                 120                 125             

Arg Ile Ser Asp Val Ser Thr Ala Lys Val Lys Ser Lys Glu Asp Met 
    130                 135                 140                 

Leu Ala Arg Gln Lys Ala Ala Gly Ile Asn Tyr Gly Ser Trp Ile Asn 
145                 150                 155                 160 

Asp Lys Val Val Phe Ala His Asn Tyr Val Glu Asn Ser Asp Asn Ile 
                165                 170                 175     

Lys Glu Asn Gln Phe Glu Asp Phe Asp Glu Asp Trp Glu Asn Phe Glu 
            180                 185                 190         

Phe Asp Ala Glu Ala Glu Pro Lys Ala Ile Lys Lys His Lys Ile Tyr 
        195                 200                 205             

Arg Pro Gln Ser Thr Gln Ala Pro Lys Glu Thr Val Ile Lys Thr Glu 
    210                 215                 220                 

Glu Thr Asp Gly Ser His Asp Ile Asp Trp Thr Gln Thr Asp Asp Asp 
225                 230                 235                 240 

Thr Lys Tyr Glu Ser His Gly Met His Val Thr Gly Ile Val Ala Gly 
                245                 250                 255     

Asn Ser Lys Glu Ala Ala Ala Thr Gly Glu Arg Phe Leu Gly Ile Ala 
            260                 265                 270         

Pro Glu Ala Gln Val Met Phe Met Arg Val Phe Ala Asn Asp Ile Met 
        275                 280                 285             

Gly Ser Ala Glu Ser Leu Phe Ile Lys Ala Ile Glu Asp Ala Val Ala 
    290                 295                 300                 

Leu Gly Ala Asp Val Ile Asn Leu Ser Leu Gly Thr Ala Asn Gly Ala 
305                 310                 315                 320 

Gln Leu Ser Gly Ser Lys Pro Leu Met Glu Ala Ile Glu Lys Ala Lys 
                325                 330                 335     

Lys Ala Gly Val Ser Val Val Val Ala Ala Gly Asn Glu Arg Val Tyr 
            340                 345                 350         

Gly Ser Asp His Asp Asp Pro Leu Ala Thr Asn Pro Asp Tyr Gly Leu 
        355                 360                 365             

Val Gly Ser Pro Ser Thr Gly Arg Thr Pro Thr Ser Val Ala Ala Ile 
    370                 375                 380                 

Asn Ser Lys Trp Val Ile Gln Arg Leu Met Thr Val Lys Glu Leu Glu 
385                 390                 395                 400 

Asn Arg Ala Asp Leu Asn His Gly Lys Ala Ile Tyr Ser Glu Ser Val 
                405                 410                 415     

Asp Phe Lys Asp Ile Lys Asp Ser Leu Gly Tyr Asp Lys Ser His Gln 
            420                 425                 430         

Phe Ala Tyr Val Lys Glu Ser Thr Asp Ala Gly Tyr Asn Ala Gln Asp 
        435                 440                 445             

Val Lys Gly Lys Ile Ala Leu Ile Glu Arg Asp Pro Asn Lys Thr Tyr 
    450                 455                 460                 

Asp Glu Met Ile Ala Leu Ala Lys Lys His Gly Ala Leu Gly Val Leu 
465                 470                 475                 480 

Ile Phe Asn Asn Lys Pro Gly Gln Ser Asn Arg Ser Met Arg Leu Thr 
                485                 490                 495     

Ala Asn Gly Met Gly Ile Pro Ser Ala Phe Ile Ser His Glu Phe Gly 
            500                 505                 510         

Lys Ala Met Ser Gln Leu Asn Gly Asn Gly Thr Gly Ser Leu Glu Phe 
        515                 520                 525             

Asp Ser Val Val Ser Lys Ala Pro Ser Gln Lys Gly Asn Glu Met Asn 
    530                 535                 540                 

His Phe Ser Asn Trp Gly Leu Thr Ser Asp Gly Tyr Leu Lys Pro Asp 
545                 550                 555                 560 

Ile Thr Ala Pro Gly Gly Asp Ile Tyr Ser Thr Tyr Asn Asp Asn His 
                565                 570                 575     

Tyr Gly Ser Gln Thr Gly Thr Ser Met Ala Ser Pro Gln Ile Ala Gly 
            580                 585                 590         

Ala Ser Leu Leu Val Lys Gln Tyr Leu Glu Lys Thr Gln Pro Asn Leu 
        595                 600                 605             

Pro Lys Glu Lys Ile Ala Asp Ile Val Lys Asn Leu Leu Met Ser Asn 
    610                 615                 620                 

Ala Gln Ile His Val Asn Pro Glu Thr Lys Thr Thr Thr Ser Pro Arg 
625                 630                 635                 640 

Gln Gln Gly Ala Gly Leu Leu Asn Ile Asp Gly Ala Val Thr Ser Gly 
                645                 650                 655     

Leu Tyr Val Thr Gly Lys Asp Asn Tyr Gly Ser Ile Ser Leu Gly Asn 
            660                 665                 670         

Ile Thr Asp Thr Met Thr Phe Asp Val Thr Val His Asn Leu Ser Asn 
        675                 680                 685             

Lys Asp Lys Thr Leu Arg Tyr Asp Thr Glu Leu Leu Thr Asp His Val 
    690                 695                 700                 

Asp Pro Gln Lys Gly Arg Phe Thr Leu Thr Ser His Ser Leu Lys Thr 
705                 710                 715                 720 

Tyr Gln Gly Gly Glu Val Thr Val Pro Ala Asn Gly Lys Val Thr Val 
                725                 730                 735     

Arg Val Thr Met Asp Val Ser Gln Phe Thr Lys Glu Leu Thr Lys Gln 
            740                 745                 750         

Met Pro Asn Gly Tyr Tyr Leu Glu Gly Phe Val Arg Phe Arg Asp Ser 
        755                 760                 765             

Gln Asp Asp Gln Leu Asn Arg Val Asn Ile Pro Phe Val Gly Phe Lys 
    770                 775                 780                 

Gly Gln Phe Glu Asn Leu Ala Val Ala Glu Glu Ser Ile Tyr Arg Leu 
785                 790                 795                 800 

Lys Ser Gln Gly Lys Thr Gly Phe Tyr Phe Asp Glu Ser Gly Pro Lys 
                805                 810                 815     

Asp Asp Ile Tyr Val Gly Lys His Phe Thr Gly Leu Val Thr Leu Gly 
            820                 825                 830         

Ser Glu Thr Asn Val Ser Thr Lys Thr Ile Ser Asp Asn Gly Leu His 
        835                 840                 845             

Thr Leu Gly Thr Phe Lys Asn Ala Asp Gly Lys Phe Ile Leu Glu Lys 
    850                 855                 860                 

Asn 
865 

<210>   10
<211>   298
<212>   PRT
<213>   Streptococcus pyogenes

<400>   10
Ser Val Gly Val Ser His Gln Val Lys Ala Asp Asp Arg Ala Ser Gly 
1               5                   10                  15      

Glu Thr Lys Ala Ser Asn Thr His Asp Asp Ser Leu Pro Lys Pro Glu 
            20                  25                  30          

Thr Ile Gln Glu Ala Lys Ala Thr Ile Asp Ala Val Glu Lys Thr Leu 
        35                  40                  45              

Ser Gln Gln Lys Ala Glu Leu Thr Glu Leu Ala Thr Ala Leu Thr Lys 
    50                  55                  60                  

Thr Thr Ala Glu Ile Asn His Leu Lys Glu Gln Gln Asp Asn Glu Gln 
65                  70                  75                  80  

Lys Ala Leu Thr Ser Ala Gln Glu Ile Tyr Thr Asn Thr Leu Ala Ser 
                85                  90                  95      

Ser Glu Glu Thr Leu Leu Ala Gln Gly Ala Glu His Gln Arg Glu Leu 
            100                 105                 110         

Thr Ala Thr Glu Thr Glu Leu His Asn Ala Gln Ala Asp Gln His Ser 
        115                 120                 125             

Lys Glu Thr Ala Leu Ser Glu Gln Lys Ala Ser Ile Ser Ala Glu Thr 
    130                 135                 140                 

Thr Arg Ala Gln Asp Leu Val Glu Gln Val Lys Thr Ser Glu Gln Asn 
145                 150                 155                 160 

Ile Ala Lys Leu Asn Ala Met Ile Ser Asn Pro Asp Ala Ile Thr Lys 
                165                 170                 175     

Ala Ala Gln Thr Ala Asn Asp Asn Thr Lys Ala Leu Ser Ser Glu Leu 
            180                 185                 190         

Glu Lys Ala Lys Ala Asp Leu Glu Asn Gln Lys Ala Lys Val Lys Lys 
        195                 200                 205             

Gln Leu Thr Glu Glu Leu Ala Ala Gln Lys Ala Ala Leu Ala Glu Lys 
    210                 215                 220                 

Glu Ala Glu Leu Ser Arg Leu Lys Ser Ser Ala Pro Ser Thr Gln Asp 
225                 230                 235                 240 

Ser Ile Val Gly Asn Asn Thr Met Lys Ala Pro Gln Gly Tyr Pro Leu 
                245                 250                 255     

Glu Glu Leu Lys Lys Leu Glu Ala Ser Gly Tyr Ile Gly Ser Ala Ser 
            260                 265                 270         

Tyr Asn Asn Tyr Tyr Lys Glu His Ala Asp Gln Ile Ile Ala Lys Ala 
        275                 280                 285             

Ser Pro Gly Asn Gln Leu Asn Gln Tyr Gln 
    290                 295             

