                         SEQUENCE LISTING

<110>  Omeros Corporation
       Schwaeble, H.
       Tedford, C.E.
       Parent, J.B.
       Dudler, T.
       Demopulos, G.A.
 
<120>  METHODS FOR TREATING DISSEMINATED INTRAVASCULAR COAGULATION BY INHIBTING MASP-2 DEPENDENT 
       COMPLEMENT ACTIVATION

<130>  OMER-1-35668

<150>  US 61/279,279
<151>  2009-10-16

<150>  US 61/322,722
<151>  2010-04-09

<160>  65    

<170>  PatentIn version 3.2

<210>  1
<211>  725
<212>  DNA
<213>  Homo sapien


<220>
<221>  CDS
<222>  (27)..(584)

<400>  1
ggccaggcca gctggacggg cacacc atg agg ctg ctg acc ctc ctg ggc ctt      53
                             Met Arg Leu Leu Thr Leu Leu Gly Leu        
                             1               5                          

ctg tgt ggc tcg gtg gcc acc ccc ttg ggc ccg aag tgg cct gaa cct      101
Leu Cys Gly Ser Val Ala Thr Pro Leu Gly Pro Lys Trp Pro Glu Pro         
10                  15                  20                  25          

gtg ttc ggg cgc ctg gca tcc ccc ggc ttt cca ggg gag tat gcc aat      149
Val Phe Gly Arg Leu Ala Ser Pro Gly Phe Pro Gly Glu Tyr Ala Asn         
                30                  35                  40              

gac cag gag cgg cgc tgg acc ctg act gca ccc ccc ggc tac cgc ctg      197
Asp Gln Glu Arg Arg Trp Thr Leu Thr Ala Pro Pro Gly Tyr Arg Leu         
            45                  50                  55                  

cgc ctc tac ttc acc cac ttc gac ctg gag ctc tcc cac ctc tgc gag      245
Arg Leu Tyr Phe Thr His Phe Asp Leu Glu Leu Ser His Leu Cys Glu         
        60                  65                  70                      

tac gac ttc gtc aag ctg agc tcg ggg gcc aag gtg ctg gcc acg ctg      293
Tyr Asp Phe Val Lys Leu Ser Ser Gly Ala Lys Val Leu Ala Thr Leu         
    75                  80                  85                          

tgc ggg cag gag agc aca gac acg gag cgg gcc cct ggc aag gac act      341
Cys Gly Gln Glu Ser Thr Asp Thr Glu Arg Ala Pro Gly Lys Asp Thr         
90                  95                  100                 105         

ttc tac tcg ctg ggc tcc agc ctg gac att acc ttc cgc tcc gac tac      389
Phe Tyr Ser Leu Gly Ser Ser Leu Asp Ile Thr Phe Arg Ser Asp Tyr         
                110                 115                 120             

tcc aac gag aag ccg ttc acg ggg ttc gag gcc ttc tat gca gcc gag      437
Ser Asn Glu Lys Pro Phe Thr Gly Phe Glu Ala Phe Tyr Ala Ala Glu         
            125                 130                 135                 

gac att gac gag tgc cag gtg gcc ccg gga gag gcg ccc acc tgc gac      485
Asp Ile Asp Glu Cys Gln Val Ala Pro Gly Glu Ala Pro Thr Cys Asp         
        140                 145                 150                     

cac cac tgc cac aac cac ctg ggc ggt ttc tac tgc tcc tgc cgc gca      533
His His Cys His Asn His Leu Gly Gly Phe Tyr Cys Ser Cys Arg Ala         
    155                 160                 165                         

ggc tac gtc ctg cac cgt aac aag cgc acc tgc tca gag cag agc ctc      581
Gly Tyr Val Leu His Arg Asn Lys Arg Thr Cys Ser Glu Gln Ser Leu         
170                 175                 180                 185         

tag cctcccctgg agctccggcc tgcccagcag gtcagaagcc agagccagcc           634

tgctggcctc agctccgggt tgggctgaga tggctgtgcc ccaactccca ttcacccacc    694

atggacccaa taataaacct ggccccaccc c                                   725


<210>  2
<211>  185
<212>  PRT
<213>  Homo sapien

<400>  2

Met Arg Leu Leu Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr 
1               5                   10                  15      


Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser 
            20                  25                  30          


Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr 
        35                  40                  45              


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60                  


Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95      


Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser 
            100                 105                 110         


Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125             


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln Val 
    130                 135                 140                 


Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His Leu 
145                 150                 155                 160 


Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg Asn 
                165                 170                 175     


Lys Arg Thr Cys Ser Glu Gln Ser Leu 
            180                 185 


<210>  3
<211>  170
<212>  PRT
<213>  Homo sapien

<400>  3

Thr Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala 
1               5                   10                  15      


Ser Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp 
            20                  25                  30          


Thr Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His 
        35                  40                  45              


Phe Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu 
    50                  55                  60                  


Ser Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr 
65                  70                  75                  80  


Asp Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser 
                85                  90                  95      


Ser Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe 
            100                 105                 110         


Thr Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln 
        115                 120                 125             


Val Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His 
    130                 135                 140                 


Leu Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg 
145                 150                 155                 160 


Asn Lys Arg Thr Cys Ser Glu Gln Ser Leu 
                165                 170 


<210>  4
<211>  2460
<212>  DNA
<213>  Homo sapien


<220>
<221>  CDS
<222>  (22)..(2082)

<400>  4
ggccagctgg acgggcacac c atg agg ctg ctg acc ctc ctg ggc ctt ctg       51
                        Met Arg Leu Leu Thr Leu Leu Gly Leu Leu         
                        1               5                   10          

tgt ggc tcg gtg gcc acc ccc ttg ggc ccg aag tgg cct gaa cct gtg       99
Cys Gly Ser Val Ala Thr Pro Leu Gly Pro Lys Trp Pro Glu Pro Val         
                15                  20                  25              

ttc ggg cgc ctg gca tcc ccc ggc ttt cca ggg gag tat gcc aat gac      147
Phe Gly Arg Leu Ala Ser Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp         
            30                  35                  40                  

cag gag cgg cgc tgg acc ctg act gca ccc ccc ggc tac cgc ctg cgc      195
Gln Glu Arg Arg Trp Thr Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg         
        45                  50                  55                      

ctc tac ttc acc cac ttc gac ctg gag ctc tcc cac ctc tgc gag tac      243
Leu Tyr Phe Thr His Phe Asp Leu Glu Leu Ser His Leu Cys Glu Tyr         
    60                  65                  70                          

gac ttc gtc aag ctg agc tcg ggg gcc aag gtg ctg gcc acg ctg tgc      291
Asp Phe Val Lys Leu Ser Ser Gly Ala Lys Val Leu Ala Thr Leu Cys         
75                  80                  85                  90          

ggg cag gag agc aca gac acg gag cgg gcc cct ggc aag gac act ttc      339
Gly Gln Glu Ser Thr Asp Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe         
                95                  100                 105             

tac tcg ctg ggc tcc agc ctg gac att acc ttc cgc tcc gac tac tcc      387
Tyr Ser Leu Gly Ser Ser Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser         
            110                 115                 120                 

aac gag aag ccg ttc acg ggg ttc gag gcc ttc tat gca gcc gag gac      435
Asn Glu Lys Pro Phe Thr Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp         
        125                 130                 135                     

att gac gag tgc cag gtg gcc ccg gga gag gcg ccc acc tgc gac cac      483
Ile Asp Glu Cys Gln Val Ala Pro Gly Glu Ala Pro Thr Cys Asp His         
    140                 145                 150                         

cac tgc cac aac cac ctg ggc ggt ttc tac tgc tcc tgc cgc gca ggc      531
His Cys His Asn His Leu Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly         
155                 160                 165                 170         

tac gtc ctg cac cgt aac aag cgc acc tgc tca gcc ctg tgc tcc ggc      579
Tyr Val Leu His Arg Asn Lys Arg Thr Cys Ser Ala Leu Cys Ser Gly         
                175                 180                 185             

cag gtc ttc acc cag agg tct ggg gag ctc agc agc cct gaa tac cca      627
Gln Val Phe Thr Gln Arg Ser Gly Glu Leu Ser Ser Pro Glu Tyr Pro         
            190                 195                 200                 

cgg ccg tat ccc aaa ctc tcc agt tgc act tac agc atc agc ctg gag      675
Arg Pro Tyr Pro Lys Leu Ser Ser Cys Thr Tyr Ser Ile Ser Leu Glu         
        205                 210                 215                     

gag ggg ttc agt gtc att ctg gac ttt gtg gag tcc ttc gat gtg gag      723
Glu Gly Phe Ser Val Ile Leu Asp Phe Val Glu Ser Phe Asp Val Glu         
    220                 225                 230                         

aca cac cct gaa acc ctg tgt ccc tac gac ttt ctc aag att caa aca      771
Thr His Pro Glu Thr Leu Cys Pro Tyr Asp Phe Leu Lys Ile Gln Thr         
235                 240                 245                 250         

gac aga gaa gaa cat ggc cca ttc tgt ggg aag aca ttg ccc cac agg      819
Asp Arg Glu Glu His Gly Pro Phe Cys Gly Lys Thr Leu Pro His Arg         
                255                 260                 265             

att gaa aca aaa agc aac acg gtg acc atc acc ttt gtc aca gat gaa      867
Ile Glu Thr Lys Ser Asn Thr Val Thr Ile Thr Phe Val Thr Asp Glu         
            270                 275                 280                 

tca gga gac cac aca ggc tgg aag atc cac tac acg agc aca gcg cag      915
Ser Gly Asp His Thr Gly Trp Lys Ile His Tyr Thr Ser Thr Ala Gln         
        285                 290                 295                     

cct tgc cct tat ccg atg gcg cca cct aat ggc cac gtt tca cct gtg      963
Pro Cys Pro Tyr Pro Met Ala Pro Pro Asn Gly His Val Ser Pro Val         
    300                 305                 310                         

caa gcc aaa tac atc ctg aaa gac agc ttc tcc atc ttt tgc gag act     1011
Gln Ala Lys Tyr Ile Leu Lys Asp Ser Phe Ser Ile Phe Cys Glu Thr         
315                 320                 325                 330         

ggc tat gag ctt ctg caa ggt cac ttg ccc ctg aaa tcc ttt act gca     1059
Gly Tyr Glu Leu Leu Gln Gly His Leu Pro Leu Lys Ser Phe Thr Ala         
                335                 340                 345             

gtt tgt cag aaa gat gga tct tgg gac cgg cca atg ccc gcg tgc agc     1107
Val Cys Gln Lys Asp Gly Ser Trp Asp Arg Pro Met Pro Ala Cys Ser         
            350                 355                 360                 

att gtt gac tgt ggc cct cct gat gat cta ccc agt ggc cga gtg gag     1155
Ile Val Asp Cys Gly Pro Pro Asp Asp Leu Pro Ser Gly Arg Val Glu         
        365                 370                 375                     

tac atc aca ggt cct gga gtg acc acc tac aaa gct gtg att cag tac     1203
Tyr Ile Thr Gly Pro Gly Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr         
    380                 385                 390                         

agc tgt gaa gag acc ttc tac aca atg aaa gtg aat gat ggt aaa tat     1251
Ser Cys Glu Glu Thr Phe Tyr Thr Met Lys Val Asn Asp Gly Lys Tyr         
395                 400                 405                 410         

gtg tgt gag gct gat gga ttc tgg acg agc tcc aaa gga gaa aaa tca     1299
Val Cys Glu Ala Asp Gly Phe Trp Thr Ser Ser Lys Gly Glu Lys Ser         
                415                 420                 425             

ctc cca gtc tgt gag cct gtt tgt gga cta tca gcc cgc aca aca gga     1347
Leu Pro Val Cys Glu Pro Val Cys Gly Leu Ser Ala Arg Thr Thr Gly         
            430                 435                 440                 

ggg cgt ata tat gga ggg caa aag gca aaa cct ggt gat ttt cct tgg     1395
Gly Arg Ile Tyr Gly Gly Gln Lys Ala Lys Pro Gly Asp Phe Pro Trp         
        445                 450                 455                     

caa gtc ctg ata tta ggt gga acc aca gca gca ggt gca ctt tta tat     1443
Gln Val Leu Ile Leu Gly Gly Thr Thr Ala Ala Gly Ala Leu Leu Tyr         
    460                 465                 470                         

gac aac tgg gtc cta aca gct gct cat gcc gtc tat gag caa aaa cat     1491
Asp Asn Trp Val Leu Thr Ala Ala His Ala Val Tyr Glu Gln Lys His         
475                 480                 485                 490         

gat gca tcc gcc ctg gac att cga atg ggc acc ctg aaa aga cta tca     1539
Asp Ala Ser Ala Leu Asp Ile Arg Met Gly Thr Leu Lys Arg Leu Ser         
                495                 500                 505             

cct cat tat aca caa gcc tgg tct gaa gct gtt ttt ata cat gaa ggt     1587
Pro His Tyr Thr Gln Ala Trp Ser Glu Ala Val Phe Ile His Glu Gly         
            510                 515                 520                 

tat act cat gat gct ggc ttt gac aat gac ata gca ctg att aaa ttg     1635
Tyr Thr His Asp Ala Gly Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu         
        525                 530                 535                     

aat aac aaa gtt gta atc aat agc aac atc acg cct att tgt ctg cca     1683
Asn Asn Lys Val Val Ile Asn Ser Asn Ile Thr Pro Ile Cys Leu Pro         
    540                 545                 550                         

aga aaa gaa gct gaa tcc ttt atg agg aca gat gac att gga act gca     1731
Arg Lys Glu Ala Glu Ser Phe Met Arg Thr Asp Asp Ile Gly Thr Ala         
555                 560                 565                 570         

tct gga tgg gga tta acc caa agg ggt ttt ctt gct aga aat cta atg     1779
Ser Gly Trp Gly Leu Thr Gln Arg Gly Phe Leu Ala Arg Asn Leu Met         
                575                 580                 585             

tat gtc gac ata ccg att gtt gac cat caa aaa tgt act gct gca tat     1827
Tyr Val Asp Ile Pro Ile Val Asp His Gln Lys Cys Thr Ala Ala Tyr         
            590                 595                 600                 

gaa aag cca ccc tat cca agg gga agt gta act gct aac atg ctt tgt     1875
Glu Lys Pro Pro Tyr Pro Arg Gly Ser Val Thr Ala Asn Met Leu Cys         
        605                 610                 615                     

gct ggc tta gaa agt ggg ggc aag gac agc tgc aga ggt gac agc gga     1923
Ala Gly Leu Glu Ser Gly Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly         
    620                 625                 630                         

ggg gca ctg gtg ttt cta gat agt gaa aca gag agg tgg ttt gtg gga     1971
Gly Ala Leu Val Phe Leu Asp Ser Glu Thr Glu Arg Trp Phe Val Gly         
635                 640                 645                 650         

gga ata gtg tcc tgg ggt tcc atg aat tgt ggg gaa gca ggt cag tat     2019
Gly Ile Val Ser Trp Gly Ser Met Asn Cys Gly Glu Ala Gly Gln Tyr         
                655                 660                 665             

gga gtc tac aca aaa gtt att aac tat att ccc tgg atc gag aac ata     2067
Gly Val Tyr Thr Lys Val Ile Asn Tyr Ile Pro Trp Ile Glu Asn Ile         
            670                 675                 680                 

att agt gat ttt taa cttgcgtgtc tgcagtcaag gattcttcat ttttagaaat     2122
Ile Ser Asp Phe                                                         
        685                                                             

gcctgtgaag accttggcag cgacgtggct cgagaagcat tcatcattac tgtggacatg   2182

gcagttgttg ctccacccaa aaaaacagac tccaggtgag gctgctgtca tttctccact   2242

tgccagttta attccagcct tacccattga ctcaagggga cataaaccac gagagtgaca   2302

gtcatctttg cccacccagt gtaatgtcac tgctcaaatt acatttcatt accttaaaaa   2362

gccagtctct tttcatactg gctgttggca tttctgtaaa ctgcctgtcc atgctctttg   2422

tttttaaact tgttcttatt gaaaaaaaaa aaaaaaaa                           2460


<210>  5
<211>  686
<212>  PRT
<213>  Homo sapien

<400>  5

Met Arg Leu Leu Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr 
1               5                   10                  15      


Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser 
            20                  25                  30          


Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr 
        35                  40                  45              


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60                  


Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95      


Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser 
            100                 105                 110         


Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125             


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln Val 
    130                 135                 140                 


Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His Leu 
145                 150                 155                 160 


Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg Asn 
                165                 170                 175     


Lys Arg Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gln Arg 
            180                 185                 190         


Ser Gly Glu Leu Ser Ser Pro Glu Tyr Pro Arg Pro Tyr Pro Lys Leu 
        195                 200                 205             


Ser Ser Cys Thr Tyr Ser Ile Ser Leu Glu Glu Gly Phe Ser Val Ile 
    210                 215                 220                 


Leu Asp Phe Val Glu Ser Phe Asp Val Glu Thr His Pro Glu Thr Leu 
225                 230                 235                 240 


Cys Pro Tyr Asp Phe Leu Lys Ile Gln Thr Asp Arg Glu Glu His Gly 
                245                 250                 255     


Pro Phe Cys Gly Lys Thr Leu Pro His Arg Ile Glu Thr Lys Ser Asn 
            260                 265                 270         


Thr Val Thr Ile Thr Phe Val Thr Asp Glu Ser Gly Asp His Thr Gly 
        275                 280                 285             


Trp Lys Ile His Tyr Thr Ser Thr Ala Gln Pro Cys Pro Tyr Pro Met 
    290                 295                 300                 


Ala Pro Pro Asn Gly His Val Ser Pro Val Gln Ala Lys Tyr Ile Leu 
305                 310                 315                 320 


Lys Asp Ser Phe Ser Ile Phe Cys Glu Thr Gly Tyr Glu Leu Leu Gln 
                325                 330                 335     


Gly His Leu Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp Gly 
            340                 345                 350         


Ser Trp Asp Arg Pro Met Pro Ala Cys Ser Ile Val Asp Cys Gly Pro 
        355                 360                 365             


Pro Asp Asp Leu Pro Ser Gly Arg Val Glu Tyr Ile Thr Gly Pro Gly 
    370                 375                 380                 


Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu Thr Phe 
385                 390                 395                 400 


Tyr Thr Met Lys Val Asn Asp Gly Lys Tyr Val Cys Glu Ala Asp Gly 
                405                 410                 415     


Phe Trp Thr Ser Ser Lys Gly Glu Lys Ser Leu Pro Val Cys Glu Pro 
            420                 425                 430         


Val Cys Gly Leu Ser Ala Arg Thr Thr Gly Gly Arg Ile Tyr Gly Gly 
        435                 440                 445             


Gln Lys Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Ile Leu Gly 
    450                 455                 460                 


Gly Thr Thr Ala Ala Gly Ala Leu Leu Tyr Asp Asn Trp Val Leu Thr 
465                 470                 475                 480 


Ala Ala His Ala Val Tyr Glu Gln Lys His Asp Ala Ser Ala Leu Asp 
                485                 490                 495     


Ile Arg Met Gly Thr Leu Lys Arg Leu Ser Pro His Tyr Thr Gln Ala 
            500                 505                 510         


Trp Ser Glu Ala Val Phe Ile His Glu Gly Tyr Thr His Asp Ala Gly 
        515                 520                 525             


Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu Asn Asn Lys Val Val Ile 
    530                 535                 540                 


Asn Ser Asn Ile Thr Pro Ile Cys Leu Pro Arg Lys Glu Ala Glu Ser 
545                 550                 555                 560 


Phe Met Arg Thr Asp Asp Ile Gly Thr Ala Ser Gly Trp Gly Leu Thr 
                565                 570                 575     


Gln Arg Gly Phe Leu Ala Arg Asn Leu Met Tyr Val Asp Ile Pro Ile 
            580                 585                 590         


Val Asp His Gln Lys Cys Thr Ala Ala Tyr Glu Lys Pro Pro Tyr Pro 
        595                 600                 605             


Arg Gly Ser Val Thr Ala Asn Met Leu Cys Ala Gly Leu Glu Ser Gly 
    610                 615                 620                 


Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe Leu 
625                 630                 635                 640 


Asp Ser Glu Thr Glu Arg Trp Phe Val Gly Gly Ile Val Ser Trp Gly 
                645                 650                 655     


Ser Met Asn Cys Gly Glu Ala Gly Gln Tyr Gly Val Tyr Thr Lys Val 
            660                 665                 670         


Ile Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile Ser Asp Phe 
        675                 680                 685     


<210>  6
<211>  671
<212>  PRT
<213>  Homo sapien

<400>  6

Thr Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala 
1               5                   10                  15      


Ser Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp 
            20                  25                  30          


Thr Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His 
        35                  40                  45              


Phe Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu 
    50                  55                  60                  


Ser Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr 
65                  70                  75                  80  


Asp Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser 
                85                  90                  95      


Ser Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe 
            100                 105                 110         


Thr Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln 
        115                 120                 125             


Val Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His 
    130                 135                 140                 


Leu Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg 
145                 150                 155                 160 


Asn Lys Arg Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gln 
                165                 170                 175     


Arg Ser Gly Glu Leu Ser Ser Pro Glu Tyr Pro Arg Pro Tyr Pro Lys 
            180                 185                 190         


Leu Ser Ser Cys Thr Tyr Ser Ile Ser Leu Glu Glu Gly Phe Ser Val 
        195                 200                 205             


Ile Leu Asp Phe Val Glu Ser Phe Asp Val Glu Thr His Pro Glu Thr 
    210                 215                 220                 


Leu Cys Pro Tyr Asp Phe Leu Lys Ile Gln Thr Asp Arg Glu Glu His 
225                 230                 235                 240 


Gly Pro Phe Cys Gly Lys Thr Leu Pro His Arg Ile Glu Thr Lys Ser 
                245                 250                 255     


Asn Thr Val Thr Ile Thr Phe Val Thr Asp Glu Ser Gly Asp His Thr 
            260                 265                 270         


Gly Trp Lys Ile His Tyr Thr Ser Thr Ala Gln Pro Cys Pro Tyr Pro 
        275                 280                 285             


Met Ala Pro Pro Asn Gly His Val Ser Pro Val Gln Ala Lys Tyr Ile 
    290                 295                 300                 


Leu Lys Asp Ser Phe Ser Ile Phe Cys Glu Thr Gly Tyr Glu Leu Leu 
305                 310                 315                 320 


Gln Gly His Leu Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp 
                325                 330                 335     


Gly Ser Trp Asp Arg Pro Met Pro Ala Cys Ser Ile Val Asp Cys Gly 
            340                 345                 350         


Pro Pro Asp Asp Leu Pro Ser Gly Arg Val Glu Tyr Ile Thr Gly Pro 
        355                 360                 365             


Gly Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu Thr 
    370                 375                 380                 


Phe Tyr Thr Met Lys Val Asn Asp Gly Lys Tyr Val Cys Glu Ala Asp 
385                 390                 395                 400 


Gly Phe Trp Thr Ser Ser Lys Gly Glu Lys Ser Leu Pro Val Cys Glu 
                405                 410                 415     


Pro Val Cys Gly Leu Ser Ala Arg Thr Thr Gly Gly Arg Ile Tyr Gly 
            420                 425                 430         


Gly Gln Lys Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Ile Leu 
        435                 440                 445             


Gly Gly Thr Thr Ala Ala Gly Ala Leu Leu Tyr Asp Asn Trp Val Leu 
    450                 455                 460                 


Thr Ala Ala His Ala Val Tyr Glu Gln Lys His Asp Ala Ser Ala Leu 
465                 470                 475                 480 


Asp Ile Arg Met Gly Thr Leu Lys Arg Leu Ser Pro His Tyr Thr Gln 
                485                 490                 495     


Ala Trp Ser Glu Ala Val Phe Ile His Glu Gly Tyr Thr His Asp Ala 
            500                 505                 510         


Gly Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu Asn Asn Lys Val Val 
        515                 520                 525             


Ile Asn Ser Asn Ile Thr Pro Ile Cys Leu Pro Arg Lys Glu Ala Glu 
    530                 535                 540                 


Ser Phe Met Arg Thr Asp Asp Ile Gly Thr Ala Ser Gly Trp Gly Leu 
545                 550                 555                 560 


Thr Gln Arg Gly Phe Leu Ala Arg Asn Leu Met Tyr Val Asp Ile Pro 
                565                 570                 575     


Ile Val Asp His Gln Lys Cys Thr Ala Ala Tyr Glu Lys Pro Pro Tyr 
            580                 585                 590         


Pro Arg Gly Ser Val Thr Ala Asn Met Leu Cys Ala Gly Leu Glu Ser 
        595                 600                 605             


Gly Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe 
    610                 615                 620                 


Leu Asp Ser Glu Thr Glu Arg Trp Phe Val Gly Gly Ile Val Ser Trp 
625                 630                 635                 640 


Gly Ser Met Asn Cys Gly Glu Ala Gly Gln Tyr Gly Val Tyr Thr Lys 
                645                 650                 655     


Val Ile Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile Ser Asp Phe 
            660                 665                 670     


<210>  7
<211>  4900
<212>  DNA
<213>  Homo sapien

<400>  7
cctgtcctgc ctgcctggaa ctctgagcag gctggagtca tggagtcgat tcccagaatc     60

ccagagtcag ggaggctggg ggcaggggca ggtcactgga caaacagatc aaaggtgaga    120

ccagcgtagg actgcagacc aggccaggcc agctggacgg gcacaccatg aggtaggtgg    180

gcgccacagc ctccctgcag ggtgtggggt gggagcacag gcctgggcct caccgcccct    240

gccctgccca taggctgctg accctcctgg gccttctgtg tggctcggtg gccaccccct    300

taggcccgaa gtggcctgaa cctgtgttcg ggcgcctggc atcccccggc tttccagggg    360

agtatgccaa tgaccaggag cggcgctgga ccctgactgc accccccggc taccgcctgc    420

gcctctactt cacccacttc gacctggagc tctcccacct ctgcgagtac gacttcgtca    480

aggtgccgtc agacgggagg gctggggttt ctcagggtcg gggggtcccc aaggagtagc    540

cagggttcag ggacacctgg gagcaggggc caggcttggc caggagggag atcaggcctg    600

ggtcttgcct tcactccctg tgacacctga ccccacagct gagctcgggg gccaaggtgc    660

tggccacgct gtgcgggcag gagagcacag acacggagcg ggcccctggc aaggacactt    720

tctactcgct gggctccagc ctggacatta ccttccgctc cgactactcc aacgagaagc    780

cgttcacggg gttcgaggcc ttctatgcag ccgagggtga gccaagaggg gtcctgcaac    840

atctcagtct gcgcagctgg ctgtgggggt aactctgtct taggccaggc agccctgcct    900

tcagtttccc cacctttccc agggcagggg agaggcctct ggcctgacat catccacaat    960

gcaaagacca aaacagccgt gacctccatt cacatgggct gagtgccaac tctgagccag   1020

ggatctgagg acagcatcgc ctcaagtgac gcagggactg gccgggcgcg gcagctcacg   1080

cctgtaattc cagcactttg ggaggccgag gctggcttga taatttgagg gtcaggagtt   1140

caaggccagc cagggcaaca cggtgaaact ctatctccac taaaactaca aaaattagct   1200

gggcgtggtg gtgcgcacct ggaatcccag ctactaggga ggctgaggca ggagaattgc   1260

ttgaacctgc gaggtggagg ctgcagtgaa cagagattgc accactacac tccacctggg   1320

cgacagacta gactccgtct caaaaaacaa aaaacaaaaa ccacgcaggg ccgagggccc   1380

atttacaagc tgacaaagtg ggccctgcca gcgggagcgc tgcaggatgt ttgattttca   1440

gatcccagtc cctgcagaga ccaactgtgt gacctctggc aagtggctca atttctctgc   1500

tccttagaag ctgctgcaag ggttcagcgc tgtagccccg ccccctgggt ttgattgact   1560

cccctcatta gctgggtgac ctcggccgga cactgaaact cccactggtt taacagaggt   1620

gatgtttgca tctttctccc agcgctgctg ggagcttgca gcgaccctag gcctgtaagg   1680

tgattggccc ggcaccagtc ccgcacccta gacaggacct aggcctcctc tgaggtccac   1740

tctgaggtca tggatctcct gggaggagtc caggctggat cccgcctctt tccctcctga   1800

cggcctgcct ggccctgcct ctcccccaga cattgacgag tgccaggtgg ccccgggaga   1860

ggcgcccacc tgcgaccacc actgccacaa ccacctgggc ggtttctact gctcctgccg   1920

cgcaggctac gtcctgcacc gtaacaagcg cacctgctca ggtgagggag gctgcctggg   1980

ccccaacgca ccctctcctg ggatacccgg ggctcctcag ggccattgct gctctgccca   2040

ggggtgcgga gggcctgggc ctggacactg ggtgcttcta ggccctgctg cctccagctc   2100

cccttctcag ccctgcttcc cctctcagca gccaggctca tcagtgccac cctgccctag   2160

cactgagact aattctaaca tcccactgtg tacctggttc cacctgggct ctgggaaccc   2220

ctcatgtagc cacgggagag tcggggtatc taccctcgtt ccttggactg ggttcctgtt   2280

ccctgcactg ggggacgggc cagtgctctg gggcgtgggc agccccaccc tgtggcgctg   2340

accctgctcc cccgactcgg tttctcctct cggggtctct ccttgcctct ctgatctctc   2400

ttccagagca gagcctctag cctcccctgg agctccggct gcccagcagg tcagaagcca   2460

gagccaggct gctggcctca gctccgggtt gggctgagat gctgtgcccc aactcccatt   2520

cacccaccat ggacccaata ataaacctgg ccccacccca cctgctgccg cgtgtctctg   2580

gggtgggagg gtcgggaggc ggtggggcgc gctcctctct gcctaccctc ctcacagcct   2640

catgaacccc aggtctgtgg gagcctcctc catggggcca cacggtcctt ggcctcaccc   2700

cctgttttga agatggggca ctgaggccgg agaggggtaa ggcctcgctc gagtccaggt   2760

ccccagaggc tgagcccaga gtaatcttga accaccccca ttcagggtct ggcctggagg   2820

agcctgaccc acagaggaga caccctggga gatattcatt gaggggtaat ctggtccccc   2880

gcaaatccag gggtgattcc cactgcccca taggcacagc cacgtggaag aaggcaggca   2940

atgttggggc tcctcacttc ctagaggcct cacaactcaa atgcccccca ctgcagctgg   3000

gggtggggtg gtggtatggg atggggacca agccttcctt gaaggataga gcccagccca   3060

acaccccgcc ccgtggcagc agcatcacgt gttccagcga ggaaggagag caccagactc   3120

agtcatgatc actgttgcct tgaacttcca agaacagccc cagggcaagg gtcaaaacag   3180

gggaaagggg gtgatgagag atccttcttc cggatgttcc tccaggaacc agggggctgg   3240

ctggtcttgg ctgggttcgg gtaggagacc catgatgaat aaacttggga atcactgggg   3300

tggctgtaag ggaatttagg ggagctccga aggggccctt aggctcgagg agatgctcct   3360

ctcttttccc gaattcccag ggacccagga gagtgtccct tcttcctctt cctgtgtgtc   3420

catccacccc cgccccccgc cctggcagag ctggtggaac tcagtgctct agcccctacc   3480

ctggggttgc gactctggct caggacacca ccacgctccc tgggggtgtg agtgagggcc   3540

tgtgcgctcc atcccgagtg ctgcctgttt cagctaaagc ctcaaagcaa gagaaacccc   3600

ctctctaagc ggcccctcag ccatcgggtg ggtcgtttgg tttctgggta ggcctcaggg   3660

gctggccacc tgcagggccc agcccaaccc agggatgcag atgtcccagc cacatccctg   3720

tcccagtttc ctgctcccca aggcatccac cctgctgttg gtgcgagggc tgatagaggg   3780

cacgccaagt cactcccctg cccttccctc cttccagccc tgtgctccgg ccaggtcttc   3840

acccagaggt ctggggagct cagcagccct gaatacccac ggccgtatcc caaactctcc   3900

agttgcactt acagcatcag cctggaggag gggttcagtg tcattctgga ctttgtggag   3960

tccttcgatg tggagacaca ccctgaaacc ctgtgtccct acgactttct caaggtctgg   4020

ctcctgggcc cctcatcttg tcccagatcc tcccccttca gcccagctgc accccctact   4080

tcctgcagca tggcccccac cacgttcccg tcaccctcgg tgaccccacc tcttcaggtg   4140

ctctatggag gtcaaggctg gggcttcgag tacaagtgtg ggaggcagag tggggagggg   4200

caccccaatc catggcctgg gttggcctca ttggctgtcc ctgaaatgct gaggaggtgg   4260

gttacttccc tccgcccagg ccagacccag gcagctgctc cccagctttc atgagcttct   4320

ttctcagatt caaacagaca gagaagaaca tggcccattc tgtgggaaga cattgcccca   4380

caggattgaa acaaaaagca acacggtgac catcaccttt gtcacagatg aatcaggaga   4440

ccacacaggc tggaagatcc actacacgag cacagtgagc aagtgggctc agatccttgg   4500

tggaagcgca gagctgcctc tctctggagt gcaaggagct gtagagtgta gggctcttct   4560

gggcaggact aggaagggac accaggttta gtggtgctga ggtctgaggc agcagcttct   4620

aaggggaagc acccgtgccc tcctcagcag cacccagcat cttcaccact cattcttcaa   4680

ccacccattc acccatcact catcttttac ccacccaccc tttgccactc atccttctgt   4740

ccctcatcct tccaaccatt catcaatcac ccacccatcc atcctttgcc acacaaccat   4800

ccacccattc ttctacctac ccatcctatc catccatcct tctatcagca tccttctacc   4860

acccatcctt cgttcggtca tccatcatca tccatccatc                         4900


<210>  8
<211>  136
<212>  PRT
<213>  Homo sapien

<400>  8

Met Arg Leu Leu Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr 
1               5                   10                  15      


Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser 
            20                  25                  30          


Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr 
        35                  40                  45              


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60                  


Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95      


Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser 
            100                 105                 110         


Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125             


Gly Phe Glu Ala Phe Tyr Ala Ala 
    130                 135     


<210>  9
<211>  181
<212>  PRT
<213>  Homo sapien

<400>  9

Met Arg Leu Leu Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr 
1               5                   10                  15      


Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser 
            20                  25                  30          


Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr 
        35                  40                  45              


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60                  


Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95      


Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser 
            100                 105                 110         


Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125             


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln Val 
    130                 135                 140                 


Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His Leu 
145                 150                 155                 160 


Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg Asn 
                165                 170                 175     


Lys Arg Thr Cys Ser 
            180     


<210>  10
<211>  293
<212>  PRT
<213>  Homo sapien

<400>  10

Met Arg Leu Leu Thr Leu Leu Gly Leu Leu Cys Gly Ser Val Ala Thr 
1               5                   10                  15      


Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Ala Ser 
            20                  25                  30          


Pro Gly Phe Pro Gly Glu Tyr Ala Asn Asp Gln Glu Arg Arg Trp Thr 
        35                  40                  45              


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60                  


Asp Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80  


Ser Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95      


Thr Glu Arg Ala Pro Gly Lys Asp Thr Phe Tyr Ser Leu Gly Ser Ser 
            100                 105                 110         


Leu Asp Ile Thr Phe Arg Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125             


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Ile Asp Glu Cys Gln Val 
    130                 135                 140                 


Ala Pro Gly Glu Ala Pro Thr Cys Asp His His Cys His Asn His Leu 
145                 150                 155                 160 


Gly Gly Phe Tyr Cys Ser Cys Arg Ala Gly Tyr Val Leu His Arg Asn 
                165                 170                 175     


Lys Arg Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gln Arg 
            180                 185                 190         


Ser Gly Glu Leu Ser Ser Pro Glu Tyr Pro Arg Pro Tyr Pro Lys Leu 
        195                 200                 205             


Ser Ser Cys Thr Tyr Ser Ile Ser Leu Glu Glu Gly Phe Ser Val Ile 
    210                 215                 220                 


Leu Asp Phe Val Glu Ser Phe Asp Val Glu Thr His Pro Glu Thr Leu 
225                 230                 235                 240 


Cys Pro Tyr Asp Phe Leu Lys Ile Gln Thr Asp Arg Glu Glu His Gly 
                245                 250                 255     


Pro Phe Cys Gly Lys Thr Leu Pro His Arg Ile Glu Thr Lys Ser Asn 
            260                 265                 270         


Thr Val Thr Ile Thr Phe Val Thr Asp Glu Ser Gly Asp His Thr Gly 
        275                 280                 285             


Trp Lys Ile His Tyr 
    290             


<210>  11
<211>  41
<212>  PRT
<213>  Homo sapien

<400>  11

Glu Asp Ile Asp Glu Cys Gln Val Ala Pro Gly Glu Ala Pro Thr Cys 
1               5                   10                  15      


Asp His His Cys His Asn His Leu Gly Gly Phe Tyr Cys Ser Cys Arg 
            20                  25                  30          


Ala Gly Tyr Val Leu His Arg Asn Lys 
        35                  40      


<210>  12
<211>  242
<212>  PRT
<213>  Homo sapien

<400>  12

Ile Tyr Gly Gly Gln Lys Ala Lys Pro Gly Asp Phe Pro Trp Gln Val 
1               5                   10                  15      


Leu Ile Leu Gly Gly Thr Thr Ala Ala Gly Ala Leu Leu Tyr Asp Asn 
            20                  25                  30          


Trp Val Leu Thr Ala Ala His Ala Val Tyr Glu Gln Lys His Asp Ala 
        35                  40                  45              


Ser Ala Leu Asp Ile Arg Met Gly Thr Leu Lys Arg Leu Ser Pro His 
    50                  55                  60                  


Tyr Thr Gln Ala Trp Ser Glu Ala Val Phe Ile His Glu Gly Tyr Thr 
65                  70                  75                  80  


His Asp Ala Gly Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu Asn Asn 
                85                  90                  95      


Lys Val Val Ile Asn Ser Asn Ile Thr Pro Ile Cys Leu Pro Arg Lys 
            100                 105                 110         


Glu Ala Glu Ser Phe Met Arg Thr Asp Asp Ile Gly Thr Ala Ser Gly 
        115                 120                 125             


Trp Gly Leu Thr Gln Arg Gly Phe Leu Ala Arg Asn Leu Met Tyr Val 
    130                 135                 140                 


Asp Ile Pro Ile Val Asp His Gln Lys Cys Thr Ala Ala Tyr Glu Lys 
145                 150                 155                 160 


Pro Pro Tyr Pro Arg Gly Ser Val Thr Ala Asn Met Leu Cys Ala Gly 
                165                 170                 175     


Leu Glu Ser Gly Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala 
            180                 185                 190         


Leu Val Phe Leu Asp Ser Glu Thr Glu Arg Trp Phe Val Gly Gly Ile 
        195                 200                 205             


Val Ser Trp Gly Ser Met Asn Cys Gly Glu Ala Gly Gln Tyr Gly Val 
    210                 215                 220                 


Tyr Thr Lys Val Ile Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile Ser 
225                 230                 235                 240 


Asp Phe 
        


<210>  13
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  13

Gly Lys Asp Ser Cys Arg Gly Asp Ala Gly Gly Ala Leu Val Phe Leu 
1               5                   10                  15      


<210>  14
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  14

Thr Pro Leu Gly Pro Lys Trp Pro Glu Pro Val Phe Gly Arg Leu 
1               5                   10                  15  


<210>  15
<211>  43
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  15

Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe Asp 
1               5                   10                  15      


Leu Glu Leu Ser His Leu Cys Glu Tyr Asp Phe Val Lys Leu Ser Ser 
            20                  25                  30          


Gly Ala Lys Val Leu Ala Thr Leu Cys Gly Gln 
        35                  40              


<210>  16
<211>  8
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  16

Thr Phe Arg Ser Asp Tyr Ser Asn 
1               5               


<210>  17
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  17

Phe Tyr Ser Leu Gly Ser Ser Leu Asp Ile Thr Phe Arg Ser Asp Tyr 
1               5                   10                  15      


Ser Asn Glu Lys Pro Phe Thr Gly Phe 
            20                  25  


<210>  18
<211>  9
<212>  PRT
<213>  Artificial

<220>
<223>  Synthetic peptide

<400>  18

Ile Asp Glu Cys Gln Val Ala Pro Gly 
1               5                   


<210>  19
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  19

Ala Asn Met Leu Cys Ala Gly Leu Glu Ser Gly Gly Lys Asp Ser Cys 
1               5                   10                  15      


Arg Gly Asp Ser Gly Gly Ala Leu Val 
            20                  25  


<210>  20
<211>  960
<212>  DNA
<213>  Homo sapien


<220>
<221>  CDS
<222>  (51)..(797)

<400>  20
attaactgag attaaccttc cctgagtttt ctcacaccaa ggtgaggacc atg tcc        56
                                                       Met Ser          
                                                       1                

ctg ttt cca tca ctc cct ctc ctt ctc ctg agt atg gtg gca gcg tct      104
Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala Ala Ser         
        5                   10                  15                      

tac tca gaa act gtg acc tgt gag gat gcc caa aag acc tgc cct gca      152
Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala Gln Lys Thr Cys Pro Ala         
    20                  25                  30                          

gtg att gcc tgt agc tct cca ggc atc aac ggc ttc cca ggc aaa gat      200
Val Ile Ala Cys Ser Ser Pro Gly Ile Asn Gly Phe Pro Gly Lys Asp         
35                  40                  45                  50          

ggg cgt gat ggc acc aag gga gaa aag ggg gaa cca ggc caa ggg ctc      248
Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly Glu Pro Gly Gln Gly Leu         
                55                  60                  65              

aga ggc tta cag ggc ccc cct gga aag ttg ggg cct cca gga aat cca      296
Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu Gly Pro Pro Gly Asn Pro         
            70                  75                  80                  

ggg cct tct ggg tca cca gga cca aag ggc caa aaa gga gac cct gga      344
Gly Pro Ser Gly Ser Pro Gly Pro Lys Gly Gln Lys Gly Asp Pro Gly         
        85                  90                  95                      

aaa agt ccg gat ggt gat agt agc ctg gct gcc tca gaa aga aaa gct      392
Lys Ser Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg Lys Ala         
    100                 105                 110                         

ctg caa aca gaa atg gca cgt atc aaa aag tgg ctc acc ttc tct ctg      440
Leu Gln Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe Ser Leu         
115                 120                 125                 130         

ggc aaa caa gtt ggg aac aag ttc ttc ctg acc aat ggt gaa ata atg      488
Gly Lys Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu Ile Met         
                135                 140                 145             

acc ttt gaa aaa gtg aag gcc ttg tgt gtc aag ttc cag gcc tct gtg      536
Thr Phe Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala Ser Val         
            150                 155                 160                 

gcc acc ccc agg aat gct gca gag aat gga gcc att cag aat ctc atc      584
Ala Thr Pro Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn Leu Ile         
        165                 170                 175                     

aag gag gaa gcc ttc ctg ggc atc act gat gag aag aca gaa ggg cag      632
Lys Glu Glu Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu Gly Gln         
    180                 185                 190                         

ttt gtg gat ctg aca gga aat aga ctg acc tac aca aac tgg aac gag      680
Phe Val Asp Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp Asn Glu         
195                 200                 205                 210         

ggt gaa ccc aac aat gct ggt tct gat gaa gat tgt gta ttg cta ctg      728
Gly Glu Pro Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu Leu Leu         
                215                 220                 225             

aaa aat ggc cag tgg aat gac gtc ccc tgc tcc acc tcc cat ctg gcc      776
Lys Asn Gly Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His Leu Ala         
            230                 235                 240                 

gtc tgt gag ttc cct atc tga agggtcatat cactcaggcc ctccttgtct         827
Val Cys Glu Phe Pro Ile                                                 
        245                                                             

ttttactgca acccacaggc ccacagtatg cttgaaaaga taaattatat caatttcctc    887

atatccagta ttgttccttt tgtgggcaat cactaaaaat gatcactaac agcaccaaca    947

aagcaataat agt                                                       960


<210>  21
<211>  248
<212>  PRT
<213>  Homo sapien

<400>  21

Met Ser Leu Phe Pro Ser Leu Pro Leu Leu Leu Leu Ser Met Val Ala 
1               5                   10                  15      


Ala Ser Tyr Ser Glu Thr Val Thr Cys Glu Asp Ala Gln Lys Thr Cys 
            20                  25                  30          


Pro Ala Val Ile Ala Cys Ser Ser Pro Gly Ile Asn Gly Phe Pro Gly 
        35                  40                  45              


Lys Asp Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly Glu Pro Gly Gln 
    50                  55                  60                  


Gly Leu Arg Gly Leu Gln Gly Pro Pro Gly Lys Leu Gly Pro Pro Gly 
65                  70                  75                  80  


Asn Pro Gly Pro Ser Gly Ser Pro Gly Pro Lys Gly Gln Lys Gly Asp 
                85                  90                  95      


Pro Gly Lys Ser Pro Asp Gly Asp Ser Ser Leu Ala Ala Ser Glu Arg 
            100                 105                 110         


Lys Ala Leu Gln Thr Glu Met Ala Arg Ile Lys Lys Trp Leu Thr Phe 
        115                 120                 125             


Ser Leu Gly Lys Gln Val Gly Asn Lys Phe Phe Leu Thr Asn Gly Glu 
    130                 135                 140                 


Ile Met Thr Phe Glu Lys Val Lys Ala Leu Cys Val Lys Phe Gln Ala 
145                 150                 155                 160 


Ser Val Ala Thr Pro Arg Asn Ala Ala Glu Asn Gly Ala Ile Gln Asn 
                165                 170                 175     


Leu Ile Lys Glu Glu Ala Phe Leu Gly Ile Thr Asp Glu Lys Thr Glu 
            180                 185                 190         


Gly Gln Phe Val Asp Leu Thr Gly Asn Arg Leu Thr Tyr Thr Asn Trp 
        195                 200                 205             


Asn Glu Gly Glu Pro Asn Asn Ala Gly Ser Asp Glu Asp Cys Val Leu 
    210                 215                 220                 


Leu Leu Lys Asn Gly Gln Trp Asn Asp Val Pro Cys Ser Thr Ser His 
225                 230                 235                 240 


Leu Ala Val Cys Glu Phe Pro Ile 
                245             


<210>  22
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide consensus sequence


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X at position 1 represents hydroxyproline

<220>
<221>  MISC_FEATURE
<222>  (4)..(4)
<223>  Wherein X at position 4 represents hydrophobic residue

<400>  22

Xaa Gly Lys Xaa Gly Pro 
1               5       


<210>  23
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Wherein X represents hydroxyproline

<400>  23

Xaa Gly Lys Leu Gly 
1               5   


<210>  24
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (9)..(15)
<223>  Wherein X at positions 9 and 15 represents hydroxyproline

<400>  24

Gly Leu Arg Gly Leu Gln Gly Pro Xaa Gly Lys Leu Gly Pro Xaa Gly 
1               5                   10                  15      


<210>  25
<211>  27
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(27)
<223>  Wherein X at positions 3, 6, 15, 21, 24, 27 represents 
       hydroxyproline

<400>  25

Gly Pro Xaa Gly Pro Xaa Gly Leu Arg Gly Leu Gln Gly Pro Xaa Gly 
1               5                   10                  15      


Lys Leu Gly Pro Xaa Gly Pro Xaa Gly Pro Xaa 
            20                  25          


<210>  26
<211>  53
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (32)..(32)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (35)..(35)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (41)..(41)
<223>  Xaa can be any naturally occurring amino acid

<220>
<221>  misc_feature
<222>  (50)..(50)
<223>  Xaa can be any naturally occurring amino acid

<400>  26

Gly Lys Asp Gly Arg Asp Gly Thr Lys Gly Glu Lys Gly Glu Pro Gly 
1               5                   10                  15      


Gln Gly Leu Arg Gly Leu Gln Gly Pro Xaa Gly Lys Leu Gly Pro Xaa 
            20                  25                  30          


Gly Asn Xaa Gly Pro Ser Gly Ser Xaa Gly Pro Lys Gly Gln Lys Gly 
        35                  40                  45              


Asp Xaa Gly Lys Ser 
    50              


<210>  27
<211>  33
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(33)
<223>  Wherein X at positions 3, 6, 12, 18, 21, 30, 33 represents 
       hydroxyproline

<400>  27

Gly Ala Xaa Gly Ser Xaa Gly Glu Lys Gly Ala Xaa Gly Pro Gln Gly 
1               5                   10                  15      


Pro Xaa Gly Pro Xaa Gly Lys Met Gly Pro Lys Gly Glu Xaa Gly Asp 
            20                  25                  30          


Xaa 
    


<210>  28
<211>  45
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide


<220>
<221>  MISC_FEATURE
<222>  (3)..(45)
<223>  Wherein X at positions 3, 6, 9, 27, 30, 36, 42, 45 represents 
       hydroxyproline

<400>  28

Gly Cys Xaa Gly Leu Xaa Gly Ala Xaa Gly Asp Lys Gly Glu Ala Gly 
1               5                   10                  15      


Thr Asn Gly Lys Arg Gly Glu Arg Gly Pro Xaa Gly Pro Xaa Gly Lys 
            20                  25                  30          


Ala Gly Pro Xaa Gly Pro Asn Gly Ala Xaa Gly Glu Xaa 
        35                  40                  45  


<210>  29
<211>  24
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  29

Leu Gln Arg Ala Leu Glu Ile Leu Pro Asn Arg Val Thr Ile Lys Ala 
1               5                   10                  15      


Asn Arg Pro Phe Leu Val Phe Ile 
            20                  


<210>  30
<211>  559
<212>  DNA
<213>  Homo sapien

<400>  30
atgaggctgc tgaccctcct gggccttctg tgtggctcgg tggccacccc cttgggcccg     60

aagtggcctg aacctgtgtt cgggcgcctg gcatcccccg gctttccagg ggagtatgcc    120

aatgaccagg agcggcgctg gaccctgact gcaccccccg gctaccgcct gcgcctctac    180

ttcacccact tcgacctgga gctctcccac ctctgcgagt acgacttcgt caagctgagc    240

tcgggggcca aggtgctggc cacgctgtgc gggcaggaga gcacagacac ggagcgggcc    300

cctggcaagg acactttcta ctcgctgggc tccagcctgg acattacctt ccgctccgac    360

tactccaacg agaagccgtt cacggggttc gaggccttct atgcagccga ggacattgac    420

gagtgccagg tggccccggg agaggcgccc acctgcgacc accactgcca caaccacctg    480

ggcggtttct actgctcctg ccgcgcaggc tacgtcctgc accgtaacaa gcgcacctgc    540

tcagccctgt gctccggcc                                                 559


<210>  31
<211>  34
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligo

<400>  31
cgggcacacc atgaggctgc tgaccctcct gggc                                 34


<210>  32
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligo

<400>  32
gacattacct tccgctccga ctccaacgag aag                                  33


<210>  33
<211>  33
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligo

<400>  33
agcagccctg aatacccacg gccgtatccc aaa                                  33


<210>  34
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligo

<400>  34
cgggatccat gaggctgctg accctc                                          26


<210>  35
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligo

<400>  35
ggaattccta ggctgcata                                                  19


<210>  36
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligo

<400>  36
ggaattccta cagggcgct                                                  19


<210>  37
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligo

<400>  37
ggaattccta gtagtggat                                                  19


<210>  38
<211>  25
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligo

<400>  38
tgcggccgct gtaggtgctg tcttt                                           25


<210>  39
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligo

<400>  39
ggaattcact cgttattctc gga                                             23


<210>  40
<211>  17
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligo

<400>  40
tccgagaata acgagtg                                                    17


<210>  41
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligo

<400>  41
cattgaaagc tttggggtag aagttgttc                                       29


<210>  42
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligo

<400>  42
cgcggccgca gctgctcaga gtgtaga                                         27


<210>  43
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligo

<400>  43
cggtaagctt cactggctca gggaaata                                        28


<210>  44
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligo

<400>  44
aagaagcttg ccgccaccat ggattggctg tggaact                              37


<210>  45
<211>  31
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligo

<400>  45
cgggatcctc aaactttctt gtccaccttg g                                    31


<210>  46
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligo

<400>  46
aagaaagctt gccgccacca tgttctcact agctct                               36


<210>  47
<211>  26
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligo

<400>  47
cgggatcctt ctccctctaa cactct                                          26


<210>  48
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide

<400>  48

Glu Pro Lys Ser Cys Asp Lys Thr His 
1               5                   


<210>  49
<211>  4960
<212>  DNA
<213>  Homo Sapien

<400>  49
ccggacgtgg tggcgcatgc ctgtaatccc agctactcgg gaggctgagg caggagaatt     60

gctcgaaccc cggaggcaga ggtttggtgg ctcacacctg taatcccagc actttgcgag    120

gctgaggcag gtgcatcgct ttggctcagg agttcaagac cagcctgggc aacacaggga    180

gacccccatc tctacaaaaa acaaaaacaa atataaaggg gataaaaaaa aaaaaaagac    240

aagacatgaa tccatgagga cagagtgtgg aagaggaagc agcagcctca aagttctgga    300

agctggaaga acagataaac aggtgtgaaa taactgcctg gaaagcaact tctttttttt    360

tttttttttt tttgaggtgg agtctcactc tgtcgtccag gctggagtgc agtggtgcga    420

tctcggatca ctgcaacctc cgcctcccag gctcaagcaa ttctcctgcc tcagcctccc    480

gagtagctgg gattataagt gcgcgctgcc acacctggat gatttttgta tttttagtag    540

agatgggatt tcaccatgtt ggtcaggctg gtctcaaact cccaacctcg tgatccaccc    600

accttggcct cccaaagtgc tgggattaca ggtataagcc accgagccca gccaaaagcg    660

acttctaagc ctgcaaggga atcgggaatt ggtggcacca ggtccttctg acagggttta    720

agaaattagc cagcctgagg ctgggcacgg tggctcacac ctgtaatccc agcactttgg    780

gaggctaagg caggtggatc acctgagggc aggagttcaa gaccagcctg accaacatgg    840

agaaacccca tccctaccaa aaataaaaaa ttagccaggt gtggtggtgc tcgcctgtaa    900

tcccagctac ttgggaggct gaggtgggag gattgcttga acacaggaag tagaggctgc    960

agtgagctat gattgcagca ctgcactgaa gccggggcaa cagaacaaga tccaaaaaaa   1020

agggaggggt gaggggcaga gccaggattt gtttccaggc tgttgttacc taggtccgac   1080

tcctggctcc cagagcagcc tgtcctgcct gcctggaact ctgagcaggc tggagtcatg   1140

gagtcgattc ccagaatccc agagtcaggg aggctggggg caggggcagg tcactggaca   1200

aacagatcaa aggtgagacc agcgtagggc tgcagaccag gccaggccag ctggacgggc   1260

acaccatgag gtaggtgggc gcccacagcc tccctgcagg gtgtggggtg ggagcacagg   1320

cctgggccct caccgcccct gccctgccca taggctgctg accctcctgg gccttctgtg   1380

tggctcggtg gccaccccct tgggcccgaa gtggcctgaa cctgtgttcg ggcgcctggc   1440

atcccccggc tttccagggg agtatgccaa tgaccaggag cggcgctgga ccctgactgc   1500

accccccggc taccgcctgc gcctctactt cacccacttc gacctggagc tctcccacct   1560

ctgcgagtac gacttcgtca aggtgccgtc aggacgggag ggctggggtt tctcagggtc   1620

ggggggtccc caaggagtag ccagggttca gggacacctg ggagcagggg ccaggcttgg   1680

ccaggaggga gatcaggcct gggtcttgcc ttcactccct gtgacacctg accccacagc   1740

tgagctcggg ggccaaggtg ctggccacgc tgtgcgggca ggagagcaca gacacggagc   1800

gggcccctgg caaggacact ttctactcgc tgggctccag cctggacatt accttccgct   1860

ccgactactc caacgagaag ccgttcacgg ggttcgaggc cttctatgca gccgagggtg   1920

agccaagagg ggtcctgcaa catctcagtc tgcgcagctg gctgtggggg taactctgtc   1980

ttaggccagg cagccctgcc ttcagtttcc ccacctttcc cagggcaggg gagaggcctc   2040

tggcctgaca tcatccacaa tgcaaagacc aaaacagccg tgacctccat tcacatgggc   2100

tgagtgccaa ctctgagcca gggatctgag gacagcatcg cctcaagtga cgcagggact   2160

ggccgggcgc agcagctcac gcctgtaatt ccagcacttt gggaggccga ggctggctga   2220

tcatttgagg tcaggagttc aaggccagcc agggcaacac ggtgaaactc tatctccact   2280

aaaactacaa aaattagctg ggcgtggtgg tgcgcacctg gaatcccagc tactagggag   2340

gctgaggcag gagaattgct tgaacctgcg aggtggaggc tgcagtgaac agagattgca   2400

ccactacact ccagcctggg cgacagagct agactccgtc tcaaaaaaca aaaaacaaaa   2460

acgacgcagg ggccgagggc cccatttaca gctgacaaag tggggccctg ccagcgggag   2520

cgctgccagg atgtttgatt tcagatccca gtccctgcag agaccaactg tgtgacctct   2580

ggcaagtggc tcaatttctc tgctccttag gaagctgctg caagggttca gcgctgtagc   2640

cccgccccct gggtttgatt gactcccctc attagctggg tgacctcggg ccggacactg   2700

aaactcccac tggtttaaca gaggtgatgt ttgcatcttt ctcccagcgc tgctgggagc   2760

ttgcagcgac cctaggcctg taaggtgatt ggcccggcac cagtcccgca ccctagacag   2820

gacgaggcct cctctgaggt ccactctgag gtcatggatc tcctgggagg agtccaggct   2880

ggatcccgcc tctttccctc ctgacggcct gcctggccct gcctctcccc cagacattga   2940

cgagtgccag gtggccccgg gagaggcgcc cacctgcgac caccactgcc acaaccacct   3000

gggcggtttc tactgctcct gccgcgcagg ctacgtcctg caccgtaaca agcgcacctg   3060

ctcagccctg tgctccggcc aggtcttcac ccagaggtct ggggagctca gcagccctga   3120

atacccacgg ccgtatccca aactctccag ttgcacttac agcatcagcc tggaggaggg   3180

gttcagtgtc attctggact ttgtggagtc cttcgatgtg gagacacacc ctgaaaccct   3240

gtgtccctac gactttctca agattcaaac agacagagaa gaacatggcc cattctgtgg   3300

gaagacattg ccccacagga ttgaaacaaa aagcaacacg gtgaccatca cctttgtcac   3360

agatgaatca ggagaccaca caggctggaa gatccactac acgagcacag cgcacgcttg   3420

cccttatccg atggcgccac ctaatggcca cgtttcacct gtgcaagcca aatacatcct   3480

gaaagacagc ttctccatct tttgcgagac tggctatgag cttctgcaag gtcacttgcc   3540

cctgaaatcc tttactgcag tttgtcagaa agatggatct tgggaccggc caatgcccgc   3600

gtgcagcatt gttgactgtg gccctcctga tgatctaccc agtggccgag tggagtacat   3660

cacaggtcct ggagtgacca cctacaaagc tgtgattcag tacagctgtg aagagacctt   3720

ctacacaatg aaagtgaatg atggtaaata tgtgtgtgag gctgatggat tctggacgag   3780

ctccaaagga gaaaaatcac tcccagtctg tgagcctgtt tgtggactat cagcccgcac   3840

aacaggaggg cgtatatatg gagggcaaaa ggcaaaacct ggtgattttc cttggcaagt   3900

cctgatatta ggtggaacca cagcagcagg tgcactttta tatgacaact gggtcctaac   3960

agctgctcat gccgtctatg agcaaaaaca tgatgcatcc gccctggaca ttcgaatggg   4020

caccctgaaa agactatcac ctcattatac acaagcctgg tctgaagctg tttttataca   4080

tgaaggttat actcatgatg ctggctttga caatgacata gcactgatta aattgaataa   4140

caaagttgta atcaatagca acatcacgcc tatttgtctg ccaagaaaag aagctgaatc   4200

ctttatgagg acagatgaca ttggaactgc atctggatgg ggattaaccc aaaggggttt   4260

tcttgctaga aatctaatgt atgtcgacat accgattgtt gaccatcaaa aatgtactgc   4320

tgcatatgaa aagccaccct atccaagggg aagtgtaact gctaacatgc tttgtgctgg   4380

cttagaaagt gggggcaagg acagctgcag aggtgacagc ggaggggcac tggtgtttct   4440

agatagtgaa acagagaggt ggtttgtggg aggaatagtg tcctggggtt ccatgaattg   4500

tggggaagca ggtcagtatg gagtctacac aaaagttatt aactatattc cctggatcga   4560

gaacataatt agtgattttt aacttgcgtg tctgcagtca aggattcttc atttttagaa   4620

atgcctgtga agaccttggc agcgacgtgg ctcgagaagc attcatcatt actgtggaca   4680

tggcagttgt tgctccaccc aaaaaaacag actccaggtg aggctgctgt catttctcca   4740

cttgccagtt taattccagc cttacccatt gactcaaggg gacataaacc acgagagtga   4800

cagtcatctt tgcccaccca gtgtaatgtc actgctcaaa ttacatttca ttaccttaaa   4860

aagccagtct cttttcatac tggctgttgg catttctgta aactgcctgt ccatgctctt   4920

tgtttttaaa cttgttctta ttgaaaaaaa aaaaaaaaaa                         4960


<210>  50
<211>  2090
<212>  DNA
<213>  Murine MASP-2 CDS


<220>
<221>  CDS
<222>  (33)..(2090)

<400>  50
ggcgctggac tgcagagcta tggtggcaca cc atg agg cta ctc atc ttc ctg       53
                                    Met Arg Leu Leu Ile Phe Leu         
                                    1               5                   

ggt ctg ctg tgg agt ttg gtg gcc aca ctt ctg ggt tca aag tgg cct      101
Gly Leu Leu Trp Ser Leu Val Ala Thr Leu Leu Gly Ser Lys Trp Pro         
        10                  15                  20                      

gaa cct gta ttc ggg cgc ctg gtg tcc cct ggc ttc cca gag aag tat      149
Glu Pro Val Phe Gly Arg Leu Val Ser Pro Gly Phe Pro Glu Lys Tyr         
    25                  30                  35                          

gct gac cat caa gat cga tcc tgg aca ctg act gca ccc cct ggc tac      197
Ala Asp His Gln Asp Arg Ser Trp Thr Leu Thr Ala Pro Pro Gly Tyr         
40                  45                  50                  55          

cgc ctg cgc ctc tac ttc acc cac ttt gac ctg gaa ctc tct tac cgc      245
Arg Leu Arg Leu Tyr Phe Thr His Phe Asp Leu Glu Leu Ser Tyr Arg         
                60                  65                  70              

tgc gag tat gac ttt gtc aag ttg agc tca ggg acc aag gtg ctg gcc      293
Cys Glu Tyr Asp Phe Val Lys Leu Ser Ser Gly Thr Lys Val Leu Ala         
            75                  80                  85                  

aca ctg tgt ggg cag gag agt aca gac act gag cag gca cct ggc aat      341
Thr Leu Cys Gly Gln Glu Ser Thr Asp Thr Glu Gln Ala Pro Gly Asn         
        90                  95                  100                     

gac acc ttc tac tca ctg ggt ccc agc cta aag gtc acc ttc cac tcc      389
Asp Thr Phe Tyr Ser Leu Gly Pro Ser Leu Lys Val Thr Phe His Ser         
    105                 110                 115                         

gac tac tcc aat gag aag ccg ttc aca ggg ttt gag gcc ttc tat gca      437
Asp Tyr Ser Asn Glu Lys Pro Phe Thr Gly Phe Glu Ala Phe Tyr Ala         
120                 125                 130                 135         

gcg gag gat gtg gat gaa tgc aga gtg tct ctg gga gac tca gtc cct      485
Ala Glu Asp Val Asp Glu Cys Arg Val Ser Leu Gly Asp Ser Val Pro         
                140                 145                 150             

tgt gac cat tat tgc cac aac tac ttg ggc ggc tac tat tgc tcc tgc      533
Cys Asp His Tyr Cys His Asn Tyr Leu Gly Gly Tyr Tyr Cys Ser Cys         
            155                 160                 165                 

aga gcg ggc tac att ctc cac cag aac aag cac acg tgc tca gcc ctt      581
Arg Ala Gly Tyr Ile Leu His Gln Asn Lys His Thr Cys Ser Ala Leu         
        170                 175                 180                     

tgt tca ggc cag gtg ttc aca gga aga tct ggg tat ctc agt agc cct      629
Cys Ser Gly Gln Val Phe Thr Gly Arg Ser Gly Tyr Leu Ser Ser Pro         
    185                 190                 195                         

gag tac ccg cag cca tac ccc aag ctc tcc agc tgc acc tac agc atc      677
Glu Tyr Pro Gln Pro Tyr Pro Lys Leu Ser Ser Cys Thr Tyr Ser Ile         
200                 205                 210                 215         

cgc ctg gag gac ggc ttc agt gtc atc ctg gac ttc gtg gag tcc ttc      725
Arg Leu Glu Asp Gly Phe Ser Val Ile Leu Asp Phe Val Glu Ser Phe         
                220                 225                 230             

gat gtg gag acg cac cct gaa gcc cag tgc ccc tat gac tcc ctc aag      773
Asp Val Glu Thr His Pro Glu Ala Gln Cys Pro Tyr Asp Ser Leu Lys         
            235                 240                 245                 

att caa aca gac aag ggg gaa cac ggc cca ttt tgt ggg aag acg ctg      821
Ile Gln Thr Asp Lys Gly Glu His Gly Pro Phe Cys Gly Lys Thr Leu         
        250                 255                 260                     

cct ccc agg att gaa act gac agc cac aag gtg acc atc acc ttt gcc      869
Pro Pro Arg Ile Glu Thr Asp Ser His Lys Val Thr Ile Thr Phe Ala         
    265                 270                 275                         

act gac gag tcg ggg aac cac aca ggc tgg aag ata cac tac aca agc      917
Thr Asp Glu Ser Gly Asn His Thr Gly Trp Lys Ile His Tyr Thr Ser         
280                 285                 290                 295         

aca gca cgg ccc tgc cct gat cca acg gcg cca cct aat ggc agc att      965
Thr Ala Arg Pro Cys Pro Asp Pro Thr Ala Pro Pro Asn Gly Ser Ile         
                300                 305                 310             

tca cct gtg caa gcc acg tat gtc ctg aag gac agg ttt tct gtc ttc     1013
Ser Pro Val Gln Ala Thr Tyr Val Leu Lys Asp Arg Phe Ser Val Phe         
            315                 320                 325                 

tgc aag aca ggc ttc gag ctt ctg caa ggt tct gtc ccc ctg aaa tca     1061
Cys Lys Thr Gly Phe Glu Leu Leu Gln Gly Ser Val Pro Leu Lys Ser         
        330                 335                 340                     

ttc act gct gtc tgt cag aaa gat gga tct tgg gac cgg ccg atg cca     1109
Phe Thr Ala Val Cys Gln Lys Asp Gly Ser Trp Asp Arg Pro Met Pro         
    345                 350                 355                         

gag tgc agc att att gat tgt ggc cct ccc gat gac cta ccc aat ggc     1157
Glu Cys Ser Ile Ile Asp Cys Gly Pro Pro Asp Asp Leu Pro Asn Gly         
360                 365                 370                 375         

cat gtg gac tat atc aca ggc cct caa gtg act acc tac aaa gct gtg     1205
His Val Asp Tyr Ile Thr Gly Pro Gln Val Thr Thr Tyr Lys Ala Val         
                380                 385                 390             

att cag tac agc tgt gaa gag act ttc tac aca atg agc agc aat ggt     1253
Ile Gln Tyr Ser Cys Glu Glu Thr Phe Tyr Thr Met Ser Ser Asn Gly         
            395                 400                 405                 

aaa tat gtg tgt gag gct gat gga ttc tgg acg agc tcc aaa gga gaa     1301
Lys Tyr Val Cys Glu Ala Asp Gly Phe Trp Thr Ser Ser Lys Gly Glu         
        410                 415                 420                     

aaa ctc ccc ccg gtt tgt gag cct gtt tgt ggg ctg tcc aca cac act     1349
Lys Leu Pro Pro Val Cys Glu Pro Val Cys Gly Leu Ser Thr His Thr         
    425                 430                 435                         

ata gga gga cgc ata gtt gga ggg cag cct gca aag cct ggt gac ttt     1397
Ile Gly Gly Arg Ile Val Gly Gly Gln Pro Ala Lys Pro Gly Asp Phe         
440                 445                 450                 455         

cct tgg caa gtc ttg ttg ctg ggt caa act aca gca gca gca ggt gca     1445
Pro Trp Gln Val Leu Leu Leu Gly Gln Thr Thr Ala Ala Ala Gly Ala         
                460                 465                 470             

ctt ata cat gac aat tgg gtc cta aca gcc gct cat gct gta tat gag     1493
Leu Ile His Asp Asn Trp Val Leu Thr Ala Ala His Ala Val Tyr Glu         
            475                 480                 485                 

aaa aga atg gca gcg tcc tcc ctg aac atc cga atg ggc atc ctc aaa     1541
Lys Arg Met Ala Ala Ser Ser Leu Asn Ile Arg Met Gly Ile Leu Lys         
        490                 495                 500                     

agg ctc tca cct cat tac act caa gcc tgg ccc gag gaa atc ttt ata     1589
Arg Leu Ser Pro His Tyr Thr Gln Ala Trp Pro Glu Glu Ile Phe Ile         
    505                 510                 515                         

cat gaa ggc tac act cac ggt gct ggt ttt gac aat gat ata gca ttg     1637
His Glu Gly Tyr Thr His Gly Ala Gly Phe Asp Asn Asp Ile Ala Leu         
520                 525                 530                 535         

att aaa ctc aag aac aaa gtc aca atc aac gga agc atc atg cct gtt     1685
Ile Lys Leu Lys Asn Lys Val Thr Ile Asn Gly Ser Ile Met Pro Val         
                540                 545                 550             

tgc cta ccg cga aaa gaa gct gca tcc tta atg aga aca gac ttc act     1733
Cys Leu Pro Arg Lys Glu Ala Ala Ser Leu Met Arg Thr Asp Phe Thr         
            555                 560                 565                 

gga act gtg gct ggc tgg ggg tta acc cag aag ggg ctt ctt gct aga     1781
Gly Thr Val Ala Gly Trp Gly Leu Thr Gln Lys Gly Leu Leu Ala Arg         
        570                 575                 580                     

aac cta atg ttt gtg gac ata cca att gct gac cac caa aaa tgt acc     1829
Asn Leu Met Phe Val Asp Ile Pro Ile Ala Asp His Gln Lys Cys Thr         
    585                 590                 595                         

acc gtg tat gaa aag ctc tat cca gga gta aga gta agc gct aac atg     1877
Thr Val Tyr Glu Lys Leu Tyr Pro Gly Val Arg Val Ser Ala Asn Met         
600                 605                 610                 615         

ctc tgt gct ggc tta gag act ggt ggc aag gac agc tgc aga ggt gac     1925
Leu Cys Ala Gly Leu Glu Thr Gly Gly Lys Asp Ser Cys Arg Gly Asp         
                620                 625                 630             

agt ggg ggg gca tta gtg ttt cta gat aat gag aca cag cga tgg ttt     1973
Ser Gly Gly Ala Leu Val Phe Leu Asp Asn Glu Thr Gln Arg Trp Phe         
            635                 640                 645                 

gtg gga gga ata gtt tcc tgg ggt tcc att aat tgt ggg gcg gca ggc     2021
Val Gly Gly Ile Val Ser Trp Gly Ser Ile Asn Cys Gly Ala Ala Gly         
        650                 655                 660                     

cag tat ggg gtc tac aca aaa gtc atc aac tat att ccc tgg aat gag     2069
Gln Tyr Gly Val Tyr Thr Lys Val Ile Asn Tyr Ile Pro Trp Asn Glu         
    665                 670                 675                         

aac ata ata agt aat ttc taa                                         2090
Asn Ile Ile Ser Asn Phe                                                 
680                 685                                                 


<210>  51
<211>  685
<212>  PRT
<213>  Murine MASP-2 CDS

<400>  51

Met Arg Leu Leu Ile Phe Leu Gly Leu Leu Trp Ser Leu Val Ala Thr 
1               5                   10                  15      


Leu Leu Gly Ser Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Val Ser 
            20                  25                  30          


Pro Gly Phe Pro Glu Lys Tyr Ala Asp His Gln Asp Arg Ser Trp Thr 
        35                  40                  45              


Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60                  


Asp Leu Glu Leu Ser Tyr Arg Cys Glu Tyr Asp Phe Val Lys Leu Ser 
65                  70                  75                  80  


Ser Gly Thr Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95      


Thr Glu Gln Ala Pro Gly Asn Asp Thr Phe Tyr Ser Leu Gly Pro Ser 
            100                 105                 110         


Leu Lys Val Thr Phe His Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125             


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Val Asp Glu Cys Arg Val 
    130                 135                 140                 


Ser Leu Gly Asp Ser Val Pro Cys Asp His Tyr Cys His Asn Tyr Leu 
145                 150                 155                 160 


Gly Gly Tyr Tyr Cys Ser Cys Arg Ala Gly Tyr Ile Leu His Gln Asn 
                165                 170                 175     


Lys His Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gly Arg 
            180                 185                 190         


Ser Gly Tyr Leu Ser Ser Pro Glu Tyr Pro Gln Pro Tyr Pro Lys Leu 
        195                 200                 205             


Ser Ser Cys Thr Tyr Ser Ile Arg Leu Glu Asp Gly Phe Ser Val Ile 
    210                 215                 220                 


Leu Asp Phe Val Glu Ser Phe Asp Val Glu Thr His Pro Glu Ala Gln 
225                 230                 235                 240 


Cys Pro Tyr Asp Ser Leu Lys Ile Gln Thr Asp Lys Gly Glu His Gly 
                245                 250                 255     


Pro Phe Cys Gly Lys Thr Leu Pro Pro Arg Ile Glu Thr Asp Ser His 
            260                 265                 270         


Lys Val Thr Ile Thr Phe Ala Thr Asp Glu Ser Gly Asn His Thr Gly 
        275                 280                 285             


Trp Lys Ile His Tyr Thr Ser Thr Ala Arg Pro Cys Pro Asp Pro Thr 
    290                 295                 300                 


Ala Pro Pro Asn Gly Ser Ile Ser Pro Val Gln Ala Thr Tyr Val Leu 
305                 310                 315                 320 


Lys Asp Arg Phe Ser Val Phe Cys Lys Thr Gly Phe Glu Leu Leu Gln 
                325                 330                 335     


Gly Ser Val Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp Gly 
            340                 345                 350         


Ser Trp Asp Arg Pro Met Pro Glu Cys Ser Ile Ile Asp Cys Gly Pro 
        355                 360                 365             


Pro Asp Asp Leu Pro Asn Gly His Val Asp Tyr Ile Thr Gly Pro Gln 
    370                 375                 380                 


Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu Thr Phe 
385                 390                 395                 400 


Tyr Thr Met Ser Ser Asn Gly Lys Tyr Val Cys Glu Ala Asp Gly Phe 
                405                 410                 415     


Trp Thr Ser Ser Lys Gly Glu Lys Leu Pro Pro Val Cys Glu Pro Val 
            420                 425                 430         


Cys Gly Leu Ser Thr His Thr Ile Gly Gly Arg Ile Val Gly Gly Gln 
        435                 440                 445             


Pro Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Leu Leu Gly Gln 
    450                 455                 460                 


Thr Thr Ala Ala Ala Gly Ala Leu Ile His Asp Asn Trp Val Leu Thr 
465                 470                 475                 480 


Ala Ala His Ala Val Tyr Glu Lys Arg Met Ala Ala Ser Ser Leu Asn 
                485                 490                 495     


Ile Arg Met Gly Ile Leu Lys Arg Leu Ser Pro His Tyr Thr Gln Ala 
            500                 505                 510         


Trp Pro Glu Glu Ile Phe Ile His Glu Gly Tyr Thr His Gly Ala Gly 
        515                 520                 525             


Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu Lys Asn Lys Val Thr Ile 
    530                 535                 540                 


Asn Gly Ser Ile Met Pro Val Cys Leu Pro Arg Lys Glu Ala Ala Ser 
545                 550                 555                 560 


Leu Met Arg Thr Asp Phe Thr Gly Thr Val Ala Gly Trp Gly Leu Thr 
                565                 570                 575     


Gln Lys Gly Leu Leu Ala Arg Asn Leu Met Phe Val Asp Ile Pro Ile 
            580                 585                 590         


Ala Asp His Gln Lys Cys Thr Thr Val Tyr Glu Lys Leu Tyr Pro Gly 
        595                 600                 605             


Val Arg Val Ser Ala Asn Met Leu Cys Ala Gly Leu Glu Thr Gly Gly 
    610                 615                 620                 


Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe Leu Asp 
625                 630                 635                 640 


Asn Glu Thr Gln Arg Trp Phe Val Gly Gly Ile Val Ser Trp Gly Ser 
                645                 650                 655     


Ile Asn Cys Gly Ala Ala Gly Gln Tyr Gly Val Tyr Thr Lys Val Ile 
            660                 665                 670         


Asn Tyr Ile Pro Trp Asn Glu Asn Ile Ile Ser Asn Phe 
        675                 680                 685 


<210>  52
<211>  670
<212>  PRT
<213>  Murine MASP-2 mature protein

<400>  52

Thr Leu Leu Gly Ser Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Val 
1               5                   10                  15      


Ser Pro Gly Phe Pro Glu Lys Tyr Ala Asp His Gln Asp Arg Ser Trp 
            20                  25                  30          


Thr Leu Thr Ala Pro Pro Gly Tyr Arg Leu Arg Leu Tyr Phe Thr His 
        35                  40                  45              


Phe Asp Leu Glu Leu Ser Tyr Arg Cys Glu Tyr Asp Phe Val Lys Leu 
    50                  55                  60                  


Ser Ser Gly Thr Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr 
65                  70                  75                  80  


Asp Thr Glu Gln Ala Pro Gly Asn Asp Thr Phe Tyr Ser Leu Gly Pro 
                85                  90                  95      


Ser Leu Lys Val Thr Phe His Ser Asp Tyr Ser Asn Glu Lys Pro Phe 
            100                 105                 110         


Thr Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Val Asp Glu Cys Arg 
        115                 120                 125             


Val Ser Leu Gly Asp Ser Val Pro Cys Asp His Tyr Cys His Asn Tyr 
    130                 135                 140                 


Leu Gly Gly Tyr Tyr Cys Ser Cys Arg Ala Gly Tyr Ile Leu His Gln 
145                 150                 155                 160 


Asn Lys His Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gly 
                165                 170                 175     


Arg Ser Gly Tyr Leu Ser Ser Pro Glu Tyr Pro Gln Pro Tyr Pro Lys 
            180                 185                 190         


Leu Ser Ser Cys Thr Tyr Ser Ile Arg Leu Glu Asp Gly Phe Ser Val 
        195                 200                 205             


Ile Leu Asp Phe Val Glu Ser Phe Asp Val Glu Thr His Pro Glu Ala 
    210                 215                 220                 


Gln Cys Pro Tyr Asp Ser Leu Lys Ile Gln Thr Asp Lys Gly Glu His 
225                 230                 235                 240 


Gly Pro Phe Cys Gly Lys Thr Leu Pro Pro Arg Ile Glu Thr Asp Ser 
                245                 250                 255     


His Lys Val Thr Ile Thr Phe Ala Thr Asp Glu Ser Gly Asn His Thr 
            260                 265                 270         


Gly Trp Lys Ile His Tyr Thr Ser Thr Ala Arg Pro Cys Pro Asp Pro 
        275                 280                 285             


Thr Ala Pro Pro Asn Gly Ser Ile Ser Pro Val Gln Ala Thr Tyr Val 
    290                 295                 300                 


Leu Lys Asp Arg Phe Ser Val Phe Cys Lys Thr Gly Phe Glu Leu Leu 
305                 310                 315                 320 


Gln Gly Ser Val Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp 
                325                 330                 335     


Gly Ser Trp Asp Arg Pro Met Pro Glu Cys Ser Ile Ile Asp Cys Gly 
            340                 345                 350         


Pro Pro Asp Asp Leu Pro Asn Gly His Val Asp Tyr Ile Thr Gly Pro 
        355                 360                 365             


Gln Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu Thr 
    370                 375                 380                 


Phe Tyr Thr Met Ser Ser Asn Gly Lys Tyr Val Cys Glu Ala Asp Gly 
385                 390                 395                 400 


Phe Trp Thr Ser Ser Lys Gly Glu Lys Leu Pro Pro Val Cys Glu Pro 
                405                 410                 415     


Val Cys Gly Leu Ser Thr His Thr Ile Gly Gly Arg Ile Val Gly Gly 
            420                 425                 430         


Gln Pro Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Leu Leu Gly 
        435                 440                 445             


Gln Thr Thr Ala Ala Ala Gly Ala Leu Ile His Asp Asn Trp Val Leu 
    450                 455                 460                 


Thr Ala Ala His Ala Val Tyr Glu Lys Arg Met Ala Ala Ser Ser Leu 
465                 470                 475                 480 


Asn Ile Arg Met Gly Ile Leu Lys Arg Leu Ser Pro His Tyr Thr Gln 
                485                 490                 495     


Ala Trp Pro Glu Glu Ile Phe Ile His Glu Gly Tyr Thr His Gly Ala 
            500                 505                 510         


Gly Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu Lys Asn Lys Val Thr 
        515                 520                 525             


Ile Asn Gly Ser Ile Met Pro Val Cys Leu Pro Arg Lys Glu Ala Ala 
    530                 535                 540                 


Ser Leu Met Arg Thr Asp Phe Thr Gly Thr Val Ala Gly Trp Gly Leu 
545                 550                 555                 560 


Thr Gln Lys Gly Leu Leu Ala Arg Asn Leu Met Phe Val Asp Ile Pro 
                565                 570                 575     


Ile Ala Asp His Gln Lys Cys Thr Thr Val Tyr Glu Lys Leu Tyr Pro 
            580                 585                 590         


Gly Val Arg Val Ser Ala Asn Met Leu Cys Ala Gly Leu Glu Thr Gly 
        595                 600                 605             


Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe Leu 
    610                 615                 620                 


Asp Asn Glu Thr Gln Arg Trp Phe Val Gly Gly Ile Val Ser Trp Gly 
625                 630                 635                 640 


Ser Ile Asn Cys Gly Ala Ala Gly Gln Tyr Gly Val Tyr Thr Lys Val 
                645                 650                 655     


Ile Asn Tyr Ile Pro Trp Asn Glu Asn Ile Ile Ser Asn Phe 
            660                 665                 670 


<210>  53
<211>  2091
<212>  DNA
<213>  Rat MASP-2 CDS


<220>
<221>  CDS
<222>  (10)..(2067)

<400>  53
tggcacaca atg agg cta ctg atc gtc ctg ggt ctg ctt tgg agt ttg gtg     51
          Met Arg Leu Leu Ile Val Leu Gly Leu Leu Trp Ser Leu Val       
          1               5                   10                        

gcc aca ctt ttg ggc tcc aag tgg cct gag cct gta ttc ggg cgc ctg       99
Ala Thr Leu Leu Gly Ser Lys Trp Pro Glu Pro Val Phe Gly Arg Leu         
15                  20                  25                  30          

gtg tcc ctg gcc ttc cca gag aag tat ggc aac cat cag gat cga tcc      147
Val Ser Leu Ala Phe Pro Glu Lys Tyr Gly Asn His Gln Asp Arg Ser         
                35                  40                  45              

tgg acg ctg act gca ccc cct ggc ttc cgc ctg cgc ctc tac ttc acc      195
Trp Thr Leu Thr Ala Pro Pro Gly Phe Arg Leu Arg Leu Tyr Phe Thr         
            50                  55                  60                  

cac ttc aac ctg gaa ctc tct tac cgc tgc gag tat gac ttt gtc aag      243
His Phe Asn Leu Glu Leu Ser Tyr Arg Cys Glu Tyr Asp Phe Val Lys         
        65                  70                  75                      

ttg acc tca ggg acc aag gtg cta gcc acg ctg tgt ggg cag gag agt      291
Leu Thr Ser Gly Thr Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser         
    80                  85                  90                          

aca gat act gag cgg gca cct ggc aat gac acc ttc tac tca ctg ggt      339
Thr Asp Thr Glu Arg Ala Pro Gly Asn Asp Thr Phe Tyr Ser Leu Gly         
95                  100                 105                 110         

ccc agc cta aag gtc acc ttc cac tcc gac tac tcc aat gag aag cca      387
Pro Ser Leu Lys Val Thr Phe His Ser Asp Tyr Ser Asn Glu Lys Pro         
                115                 120                 125             

ttc aca gga ttt gag gcc ttc tat gca gcg gag gat gtg gat gaa tgc      435
Phe Thr Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Val Asp Glu Cys         
            130                 135                 140                 

aga aca tcc ctg gga gac tca gtc cct tgt gac cat tat tgc cac aac      483
Arg Thr Ser Leu Gly Asp Ser Val Pro Cys Asp His Tyr Cys His Asn         
        145                 150                 155                     

tac ctg ggc ggc tac tac tgc tcc tgc cga gtg ggc tac att ctg cac      531
Tyr Leu Gly Gly Tyr Tyr Cys Ser Cys Arg Val Gly Tyr Ile Leu His         
    160                 165                 170                         

cag aac aag cat acc tgc tca gcc ctt tgt tca ggc cag gtg ttc act      579
Gln Asn Lys His Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr         
175                 180                 185                 190         

ggg agg tct ggc ttt ctc agt agc cct gag tac cca cag cca tac ccc      627
Gly Arg Ser Gly Phe Leu Ser Ser Pro Glu Tyr Pro Gln Pro Tyr Pro         
                195                 200                 205             

aaa ctc tcc agc tgc gcc tac aac atc cgc ctg gag gaa ggc ttc agt      675
Lys Leu Ser Ser Cys Ala Tyr Asn Ile Arg Leu Glu Glu Gly Phe Ser         
            210                 215                 220                 

atc acc ctg gac ttc gtg gag tcc ttt gat gtg gag atg cac cct gaa      723
Ile Thr Leu Asp Phe Val Glu Ser Phe Asp Val Glu Met His Pro Glu         
        225                 230                 235                     

gcc cag tgc ccc tac gac tcc ctc aag att caa aca gac aag agg gaa      771
Ala Gln Cys Pro Tyr Asp Ser Leu Lys Ile Gln Thr Asp Lys Arg Glu         
    240                 245                 250                         

tac ggc ccg ttt tgt ggg aag acg ctg ccc ccc agg att gaa act gac      819
Tyr Gly Pro Phe Cys Gly Lys Thr Leu Pro Pro Arg Ile Glu Thr Asp         
255                 260                 265                 270         

agc aac aag gtg acc att acc ttt acc acc gac gag tca ggg aac cac      867
Ser Asn Lys Val Thr Ile Thr Phe Thr Thr Asp Glu Ser Gly Asn His         
                275                 280                 285             

aca ggc tgg aag ata cac tac aca agc aca gca cag ccc tgc cct gat      915
Thr Gly Trp Lys Ile His Tyr Thr Ser Thr Ala Gln Pro Cys Pro Asp         
            290                 295                 300                 

cca acg gcg cca cct aat ggt cac att tca cct gtg caa gcc acg tat      963
Pro Thr Ala Pro Pro Asn Gly His Ile Ser Pro Val Gln Ala Thr Tyr         
        305                 310                 315                     

gtc ctg aag gac agc ttt tct gtc ttc tgc aag act ggc ttc gag ctt     1011
Val Leu Lys Asp Ser Phe Ser Val Phe Cys Lys Thr Gly Phe Glu Leu         
    320                 325                 330                         

ctg caa ggt tct gtc ccc ctg aag tca ttc act gct gtc tgt cag aaa     1059
Leu Gln Gly Ser Val Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys         
335                 340                 345                 350         

gat gga tct tgg gac cgg ccg ata cca gag tgc agc att att gac tgt     1107
Asp Gly Ser Trp Asp Arg Pro Ile Pro Glu Cys Ser Ile Ile Asp Cys         
                355                 360                 365             

ggc cct ccc gat gac cta ccc aat ggc cac gtg gac tat atc aca ggc     1155
Gly Pro Pro Asp Asp Leu Pro Asn Gly His Val Asp Tyr Ile Thr Gly         
            370                 375                 380                 

cct gaa gtg acc acc tac aaa gct gtg att cag tac agc tgt gaa gag     1203
Pro Glu Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu         
        385                 390                 395                     

act ttc tac aca atg agc agc aat ggt aaa tat gtg tgt gag gct gat     1251
Thr Phe Tyr Thr Met Ser Ser Asn Gly Lys Tyr Val Cys Glu Ala Asp         
    400                 405                 410                         

gga ttc tgg acg agc tcc aaa gga gaa aaa tcc ctc ccg gtt tgc aag     1299
Gly Phe Trp Thr Ser Ser Lys Gly Glu Lys Ser Leu Pro Val Cys Lys         
415                 420                 425                 430         

cct gtc tgt gga ctg tcc aca cac act tca gga ggc cgt ata att gga     1347
Pro Val Cys Gly Leu Ser Thr His Thr Ser Gly Gly Arg Ile Ile Gly         
                435                 440                 445             

gga cag cct gca aag cct ggt gac ttt cct tgg caa gtc ttg tta ctg     1395
Gly Gln Pro Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Leu Leu         
            450                 455                 460                 

ggt gaa act aca gca gca ggt gct ctt ata cat gac gac tgg gtc cta     1443
Gly Glu Thr Thr Ala Ala Gly Ala Leu Ile His Asp Asp Trp Val Leu         
        465                 470                 475                     

aca gcg gct cat gct gta tat ggg aaa aca gag gcg atg tcc tcc ctg     1491
Thr Ala Ala His Ala Val Tyr Gly Lys Thr Glu Ala Met Ser Ser Leu         
    480                 485                 490                         

gac atc cgc atg ggc atc ctc aaa agg ctc tcc ctc att tac act caa     1539
Asp Ile Arg Met Gly Ile Leu Lys Arg Leu Ser Leu Ile Tyr Thr Gln         
495                 500                 505                 510         

gcc tgg cca gag gct gtc ttt atc cat gaa ggc tac act cac gga gct     1587
Ala Trp Pro Glu Ala Val Phe Ile His Glu Gly Tyr Thr His Gly Ala         
                515                 520                 525             

ggt ttt gac aat gat ata gca ctg att aaa ctc aag aac aaa gtc aca     1635
Gly Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu Lys Asn Lys Val Thr         
            530                 535                 540                 

atc aac aga aac atc atg ccg att tgt cta cca aga aaa gaa gct gca     1683
Ile Asn Arg Asn Ile Met Pro Ile Cys Leu Pro Arg Lys Glu Ala Ala         
        545                 550                 555                     

tcc tta atg aaa aca gac ttc gtt gga act gtg gct ggc tgg ggg tta     1731
Ser Leu Met Lys Thr Asp Phe Val Gly Thr Val Ala Gly Trp Gly Leu         
    560                 565                 570                         

acc cag aag ggg ttt ctt gct aga aac cta atg ttt gtg gac ata cca     1779
Thr Gln Lys Gly Phe Leu Ala Arg Asn Leu Met Phe Val Asp Ile Pro         
575                 580                 585                 590         

att gtt gac cac caa aaa tgt gct act gcg tat aca aag cag ccc tac     1827
Ile Val Asp His Gln Lys Cys Ala Thr Ala Tyr Thr Lys Gln Pro Tyr         
                595                 600                 605             

cca gga gca aaa gtg act gtt aac atg ctc tgt gct ggc cta gac cgc     1875
Pro Gly Ala Lys Val Thr Val Asn Met Leu Cys Ala Gly Leu Asp Arg         
            610                 615                 620                 

ggt ggc aag gac agc tgc aga ggt gac agc gga ggg gca tta gtg ttt     1923
Gly Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe         
        625                 630                 635                     

cta gac aat gaa aca cag aga tgg ttt gtg gga gga ata gtt tcc tgg     1971
Leu Asp Asn Glu Thr Gln Arg Trp Phe Val Gly Gly Ile Val Ser Trp         
    640                 645                 650                         

ggt tct att aac tgt ggg ggg tca gaa cag tat ggg gtc tac acg aaa     2019
Gly Ser Ile Asn Cys Gly Gly Ser Glu Gln Tyr Gly Val Tyr Thr Lys         
655                 660                 665                 670         

gtc acg aac tat att ccc tgg att gag aac ata ata aat aat ttc taa     2067
Val Thr Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile Asn Asn Phe             
                675                 680                 685             

tttgcaaaaa aaaaaaaaaa aaaa                                          2091


<210>  54
<211>  685
<212>  PRT
<213>  Rat MASP-2 CDS

<400>  54

Met Arg Leu Leu Ile Val Leu Gly Leu Leu Trp Ser Leu Val Ala Thr 
1               5                   10                  15      


Leu Leu Gly Ser Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Val Ser 
            20                  25                  30          


Leu Ala Phe Pro Glu Lys Tyr Gly Asn His Gln Asp Arg Ser Trp Thr 
        35                  40                  45              


Leu Thr Ala Pro Pro Gly Phe Arg Leu Arg Leu Tyr Phe Thr His Phe 
    50                  55                  60                  


Asn Leu Glu Leu Ser Tyr Arg Cys Glu Tyr Asp Phe Val Lys Leu Thr 
65                  70                  75                  80  


Ser Gly Thr Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr Asp 
                85                  90                  95      


Thr Glu Arg Ala Pro Gly Asn Asp Thr Phe Tyr Ser Leu Gly Pro Ser 
            100                 105                 110         


Leu Lys Val Thr Phe His Ser Asp Tyr Ser Asn Glu Lys Pro Phe Thr 
        115                 120                 125             


Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Val Asp Glu Cys Arg Thr 
    130                 135                 140                 


Ser Leu Gly Asp Ser Val Pro Cys Asp His Tyr Cys His Asn Tyr Leu 
145                 150                 155                 160 


Gly Gly Tyr Tyr Cys Ser Cys Arg Val Gly Tyr Ile Leu His Gln Asn 
                165                 170                 175     


Lys His Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gly Arg 
            180                 185                 190         


Ser Gly Phe Leu Ser Ser Pro Glu Tyr Pro Gln Pro Tyr Pro Lys Leu 
        195                 200                 205             


Ser Ser Cys Ala Tyr Asn Ile Arg Leu Glu Glu Gly Phe Ser Ile Thr 
    210                 215                 220                 


Leu Asp Phe Val Glu Ser Phe Asp Val Glu Met His Pro Glu Ala Gln 
225                 230                 235                 240 


Cys Pro Tyr Asp Ser Leu Lys Ile Gln Thr Asp Lys Arg Glu Tyr Gly 
                245                 250                 255     


Pro Phe Cys Gly Lys Thr Leu Pro Pro Arg Ile Glu Thr Asp Ser Asn 
            260                 265                 270         


Lys Val Thr Ile Thr Phe Thr Thr Asp Glu Ser Gly Asn His Thr Gly 
        275                 280                 285             


Trp Lys Ile His Tyr Thr Ser Thr Ala Gln Pro Cys Pro Asp Pro Thr 
    290                 295                 300                 


Ala Pro Pro Asn Gly His Ile Ser Pro Val Gln Ala Thr Tyr Val Leu 
305                 310                 315                 320 


Lys Asp Ser Phe Ser Val Phe Cys Lys Thr Gly Phe Glu Leu Leu Gln 
                325                 330                 335     


Gly Ser Val Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp Gly 
            340                 345                 350         


Ser Trp Asp Arg Pro Ile Pro Glu Cys Ser Ile Ile Asp Cys Gly Pro 
        355                 360                 365             


Pro Asp Asp Leu Pro Asn Gly His Val Asp Tyr Ile Thr Gly Pro Glu 
    370                 375                 380                 


Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu Thr Phe 
385                 390                 395                 400 


Tyr Thr Met Ser Ser Asn Gly Lys Tyr Val Cys Glu Ala Asp Gly Phe 
                405                 410                 415     


Trp Thr Ser Ser Lys Gly Glu Lys Ser Leu Pro Val Cys Lys Pro Val 
            420                 425                 430         


Cys Gly Leu Ser Thr His Thr Ser Gly Gly Arg Ile Ile Gly Gly Gln 
        435                 440                 445             


Pro Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Leu Leu Gly Glu 
    450                 455                 460                 


Thr Thr Ala Ala Gly Ala Leu Ile His Asp Asp Trp Val Leu Thr Ala 
465                 470                 475                 480 


Ala His Ala Val Tyr Gly Lys Thr Glu Ala Met Ser Ser Leu Asp Ile 
                485                 490                 495     


Arg Met Gly Ile Leu Lys Arg Leu Ser Leu Ile Tyr Thr Gln Ala Trp 
            500                 505                 510         


Pro Glu Ala Val Phe Ile His Glu Gly Tyr Thr His Gly Ala Gly Phe 
        515                 520                 525             


Asp Asn Asp Ile Ala Leu Ile Lys Leu Lys Asn Lys Val Thr Ile Asn 
    530                 535                 540                 


Arg Asn Ile Met Pro Ile Cys Leu Pro Arg Lys Glu Ala Ala Ser Leu 
545                 550                 555                 560 


Met Lys Thr Asp Phe Val Gly Thr Val Ala Gly Trp Gly Leu Thr Gln 
                565                 570                 575     


Lys Gly Phe Leu Ala Arg Asn Leu Met Phe Val Asp Ile Pro Ile Val 
            580                 585                 590         


Asp His Gln Lys Cys Ala Thr Ala Tyr Thr Lys Gln Pro Tyr Pro Gly 
        595                 600                 605             


Ala Lys Val Thr Val Asn Met Leu Cys Ala Gly Leu Asp Arg Gly Gly 
    610                 615                 620                 


Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe Leu Asp 
625                 630                 635                 640 


Asn Glu Thr Gln Arg Trp Phe Val Gly Gly Ile Val Ser Trp Gly Ser 
                645                 650                 655     


Ile Asn Cys Gly Gly Ser Glu Gln Tyr Gly Val Tyr Thr Lys Val Thr 
            660                 665                 670         


Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile Asn Asn Phe 
        675                 680                 685 


<210>  55
<211>  670
<212>  PRT
<213>  Rat MASP-2 mature protein

<400>  55

Thr Leu Leu Gly Ser Lys Trp Pro Glu Pro Val Phe Gly Arg Leu Val 
1               5                   10                  15      


Ser Leu Ala Phe Pro Glu Lys Tyr Gly Asn His Gln Asp Arg Ser Trp 
            20                  25                  30          


Thr Leu Thr Ala Pro Pro Gly Phe Arg Leu Arg Leu Tyr Phe Thr His 
        35                  40                  45              


Phe Asn Leu Glu Leu Ser Tyr Arg Cys Glu Tyr Asp Phe Val Lys Leu 
    50                  55                  60                  


Thr Ser Gly Thr Lys Val Leu Ala Thr Leu Cys Gly Gln Glu Ser Thr 
65                  70                  75                  80  


Asp Thr Glu Arg Ala Pro Gly Asn Asp Thr Phe Tyr Ser Leu Gly Pro 
                85                  90                  95      


Ser Leu Lys Val Thr Phe His Ser Asp Tyr Ser Asn Glu Lys Pro Phe 
            100                 105                 110         


Thr Gly Phe Glu Ala Phe Tyr Ala Ala Glu Asp Val Asp Glu Cys Arg 
        115                 120                 125             


Thr Ser Leu Gly Asp Ser Val Pro Cys Asp His Tyr Cys His Asn Tyr 
    130                 135                 140                 


Leu Gly Gly Tyr Tyr Cys Ser Cys Arg Val Gly Tyr Ile Leu His Gln 
145                 150                 155                 160 


Asn Lys His Thr Cys Ser Ala Leu Cys Ser Gly Gln Val Phe Thr Gly 
                165                 170                 175     


Arg Ser Gly Phe Leu Ser Ser Pro Glu Tyr Pro Gln Pro Tyr Pro Lys 
            180                 185                 190         


Leu Ser Ser Cys Ala Tyr Asn Ile Arg Leu Glu Glu Gly Phe Ser Ile 
        195                 200                 205             


Thr Leu Asp Phe Val Glu Ser Phe Asp Val Glu Met His Pro Glu Ala 
    210                 215                 220                 


Gln Cys Pro Tyr Asp Ser Leu Lys Ile Gln Thr Asp Lys Arg Glu Tyr 
225                 230                 235                 240 


Gly Pro Phe Cys Gly Lys Thr Leu Pro Pro Arg Ile Glu Thr Asp Ser 
                245                 250                 255     


Asn Lys Val Thr Ile Thr Phe Thr Thr Asp Glu Ser Gly Asn His Thr 
            260                 265                 270         


Gly Trp Lys Ile His Tyr Thr Ser Thr Ala Gln Pro Cys Pro Asp Pro 
        275                 280                 285             


Thr Ala Pro Pro Asn Gly His Ile Ser Pro Val Gln Ala Thr Tyr Val 
    290                 295                 300                 


Leu Lys Asp Ser Phe Ser Val Phe Cys Lys Thr Gly Phe Glu Leu Leu 
305                 310                 315                 320 


Gln Gly Ser Val Pro Leu Lys Ser Phe Thr Ala Val Cys Gln Lys Asp 
                325                 330                 335     


Gly Ser Trp Asp Arg Pro Ile Pro Glu Cys Ser Ile Ile Asp Cys Gly 
            340                 345                 350         


Pro Pro Asp Asp Leu Pro Asn Gly His Val Asp Tyr Ile Thr Gly Pro 
        355                 360                 365             


Glu Val Thr Thr Tyr Lys Ala Val Ile Gln Tyr Ser Cys Glu Glu Thr 
    370                 375                 380                 


Phe Tyr Thr Met Ser Ser Asn Gly Lys Tyr Val Cys Glu Ala Asp Gly 
385                 390                 395                 400 


Phe Trp Thr Ser Ser Lys Gly Glu Lys Ser Leu Pro Val Cys Lys Pro 
                405                 410                 415     


Val Cys Gly Leu Ser Thr His Thr Ser Gly Gly Arg Ile Ile Gly Gly 
            420                 425                 430         


Gln Pro Ala Lys Pro Gly Asp Phe Pro Trp Gln Val Leu Leu Leu Gly 
        435                 440                 445             


Glu Thr Thr Ala Ala Gly Ala Leu Ile His Asp Asp Trp Val Leu Thr 
    450                 455                 460                 


Ala Ala His Ala Val Tyr Gly Lys Thr Glu Ala Met Ser Ser Leu Asp 
465                 470                 475                 480 


Ile Arg Met Gly Ile Leu Lys Arg Leu Ser Leu Ile Tyr Thr Gln Ala 
                485                 490                 495     


Trp Pro Glu Ala Val Phe Ile His Glu Gly Tyr Thr His Gly Ala Gly 
            500                 505                 510         


Phe Asp Asn Asp Ile Ala Leu Ile Lys Leu Lys Asn Lys Val Thr Ile 
        515                 520                 525             


Asn Arg Asn Ile Met Pro Ile Cys Leu Pro Arg Lys Glu Ala Ala Ser 
    530                 535                 540                 


Leu Met Lys Thr Asp Phe Val Gly Thr Val Ala Gly Trp Gly Leu Thr 
545                 550                 555                 560 


Gln Lys Gly Phe Leu Ala Arg Asn Leu Met Phe Val Asp Ile Pro Ile 
                565                 570                 575     


Val Asp His Gln Lys Cys Ala Thr Ala Tyr Thr Lys Gln Pro Tyr Pro 
            580                 585                 590         


Gly Ala Lys Val Thr Val Asn Met Leu Cys Ala Gly Leu Asp Arg Gly 
        595                 600                 605             


Gly Lys Asp Ser Cys Arg Gly Asp Ser Gly Gly Ala Leu Val Phe Leu 
    610                 615                 620                 


Asp Asn Glu Thr Gln Arg Trp Phe Val Gly Gly Ile Val Ser Trp Gly 
625                 630                 635                 640 


Ser Ile Asn Cys Gly Gly Ser Glu Gln Tyr Gly Val Tyr Thr Lys Val 
                645                 650                 655     


Thr Asn Tyr Ile Pro Trp Ile Glu Asn Ile Ile Asn Asn Phe 
            660                 665                 670 


<210>  56
<211>  28
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homo Sapien MASP-2 PCR primer

<400>  56
atgaggctgc tgaccctcct gggccttc                                        28


<210>  57
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homo Sapien MASP-2 PCR primer

<400>  57
gtgcccctcc tgcgtcacct ctg                                             23


<210>  58
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homo Sapien MASP-2 PCR primer

<400>  58
cagaggtgac gcaggagggg cac                                             23


<210>  59
<211>  27
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Homo Sapien MASP-2 PCR primer

<400>  59
ttaaaatcac taattatgtt ctcgatc                                         27


<210>  60
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Murine MASP-2 PCR primer

<400>  60
atgaggctac tcatcttcct gg                                              22


<210>  61
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Murine MASP-2 PCR primer

<400>  61
ctgcagaggt gacgcagggg ggg                                             23


<210>  62
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Murine MASP-2 PCR primer

<400>  62
ccccccctgc gtcacctctg cag                                             23


<210>  63
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Murine MASP-2 PCR primer

<400>  63
ttagaaatta cttattatgt tctcaatcc                                       29


<210>  64
<211>  29
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide from rat MASP-2

<400>  64
gaggtgacgc aggaggggca ttagtgttt                                       29


<210>  65
<211>  37
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Oligonucleotide from rat MASP-2

<400>  65
ctagaaacac taatgcccct cctgcgtcac ctctgca                              37


