
                                SEQUENCE LISTING

<110> Smith, Larry J.

<120> Methods and Compositions for Modulating
  Gene Expression Using Oligonucleotide Based Drugs
  Administered In Vivo or In Vitro
  

<130> 2273-P04933WO00

<140> PCT/US2010/052399   
<141> 2010-10-12  

<150> 61/250,714          
<151> 2009-10-12  

<160> 378

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 40
<212> RNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 1
cagaccuaug gaaacuacuu aaguaguuuc cauaggucug                       40

<210> 2
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 2
Gly Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg
 1               5                  10          


<210> 3
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 3
Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg
 1               5                  10      


<210> 4
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 4
Cys Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg
 1               5                  10          


<210> 5
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 5
Arg Lys Lys Arg Arg Gln Arg Arg Arg Pro Pro Gln Cys
 1               5                  10              


<210> 6
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 6
Cys Tyr Gln Arg Lys Lys Arg Arg Gln Arg Arg Arg
 1               5                  10          


<210> 7
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 7
Arg Lys Lys Arg Arg Gln Arg Arg Arg
 1               5                  


<210> 8
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = Phe or Trp

<400> 8
Gly Ala Leu Phe Leu Gly Xaa Leu Gly Ala Ala Gly Ser Thr Met Gly
 1               5                  10                  15      
Ala
    


<210> 9
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = Phe or Trp

<400> 9
Gly Ala Leu Phe Leu Gly Xaa Leu Gly Ala Ala Gly Ser Thr Met Gly
 1               5                  10                  15      
Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val
            20                  25          


<210> 10
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> VARIANT        
<222> 7
<223> Xaa = Phe or Trp

<400> 10
Gly Ala Leu Phe Leu Gly Xaa Leu Gly Ala Ala Gly Ser Thr Met Gly
 1               5                  10                  15      
Ala Trp Ser Gln Pro Lys Ser Lys Arg Lys Val
            20                  25          


<210> 11
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 11
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys
 1               5                  10                  15      


<210> 12
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 12
Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys
 1               5                  10                  15      
Gly Gly Cys
            


<210> 13
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 13
Leu Ile Arg Leu Trp Ser His Leu Ile His Ile Trp Phe Gln Asn Arg
 1               5                  10                  15      
Arg Leu Lys Trp Lys Lys Lys
            20              


<210> 14
<211> 36
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 14
Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly
 1               5                  10                  15      
Met Ile Asp Gly Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met
            20                  25                  30          
Lys Trp Lys Lys
        35      


<210> 15
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 15
Phe Phe Gly Ala Val Ile Gly Thr Ile Ala Leu Gly Val Ala Thr Ala
 1               5                  10                  15      


<210> 16
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 16
Phe Leu Gly Phe Leu Leu Gly Val Gly Ser Ala Ile Ala Ser Gly Val
 1               5                  10                  15      


<210> 17
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 17
Gly Val Phe Val Leu Gly Phe Leu Gly Phe Leu Ala Thr Ala Gly Ser
 1               5                  10                  15      


<210> 18
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 18
Gly Ala Ala Ile Gly Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala
 1               5                  10                  15      


<210> 19
<211> 34
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> VARIANT        
<222> 34
<223> Xaa = Asp or Glu

<400> 19
Asp Ala Ala Thr Ala Thr Arg Gly Arg Ser Ala Ala Ser Arg Pro Thr
 1               5                  10                  15      
Glu Arg Pro Arg Ala Pro Ala Arg Ser Ala Ser Arg Pro Arg Arg Pro
            20                  25                  30          
Val Xaa
        


<210> 20
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 20
Lys Leu Ala Lys Leu Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys
 1               5                  10                  15      
Leu Ala
        


<210> 21
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 21
Lys Leu Ala Leu Lys Leu Ala Leu Lys Ala Leu Lys Ala Ala Leu Lys
 1               5                  10                  15      
Leu Ala
        


<210> 22
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 22
Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys
 1               5                  10                  15      
Lys Lys Arg Lys Val
            20      


<210> 23
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 23
Lys Glu Thr Trp Phe Glu Thr Trp Phe Thr Glu Trp Ser Gln Pro Lys
 1               5                  10                  15      
Lys Lys Arg Lys Val
            20      


<210> 24
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> VARIANT        
<222> 2, 3, 10-12, 18, 21
<223> Xaa = any or no amino acid

<400> 24
Lys Xaa Xaa Trp Trp Glu Thr Trp Trp Xaa Xaa Xaa Ser Gln Pro Lys
 1               5                  10                  15      
Lys Xaa Arg Lys Xaa
            20      


<210> 25
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 25
Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Trp Ser Gln Pro Lys
 1               5                  10                  15      
Lys Arg Lys Val
            20  


<210> 26
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 26
Lys Glu Thr Trp Trp Glu Thr Trp Trp Thr Glu Ala Ser Gln Pro Lys
 1               5                  10                  15      
Lys Arg Lys Val
            20  


<210> 27
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 27
Lys Glu Thr Trp Trp Glu Thr Trp Trp Glu Thr Trp Ser Gln Pro Lys
 1               5                  10                  15      
Lys Lys Arg Lys Val
            20      


<210> 28
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 28
Lys Glu Thr Trp Trp Glu Thr Trp Thr Trp Ser Gln Pro Lys Lys Lys
 1               5                  10                  15      
Arg Lys Val
            


<210> 29
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 29
Lys Trp Trp Glu Thr Trp Trp Glu Thr Trp Ser Gln Pro Lys Lys Lys
 1               5                  10                  15      
Arg Lys Val
            


<210> 30
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> VARIANT        
<222> 10, 11
<223> Xaa = any or no amino acid

<400> 30
Lys Glu Thr Trp Trp Glu Thr Trp Trp Xaa Xaa Trp Ser Gln Pro Lys
 1               5                  10                  15      
Lys Lys Arg Lys Val
            20      


<210> 31
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 31
Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met
 1               5                  10                  15  


<210> 32
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 32
Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met Gly
 1               5                  10                  15      
Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val
            20                  25          


<210> 33
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 33
Met Val Lys Ser Lys Ile Gly Ser Trp Ile Leu Val Leu Phe Val Ala
 1               5                  10                  15      
Met Trp Ser Asp Val Gly Leu Cys Lys Lys Arg Pro Lys Pro
            20                  25                  30  


<210> 34
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 34
Arg Gly Gly Arg Leu Ser Tyr Ser Arg Arg Arg Phe Ser Thr Ser Thr
 1               5                  10                  15      
Gly Arg
        


<210> 35
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 35
Arg Arg Leu Ser Tyr Ser Arg Arg Arg Phe
 1               5                  10  


<210> 36
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 36
Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu
 1               5                  10                  15      
Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu
            20                  25          


<210> 37
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 37
Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu Lys Ala Leu Ala Ala Leu
 1               5                  10                  15      
Ala Lys Lys Ile Leu
            20      


<210> 38
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 38
Arg Arg Arg Arg Arg Arg Trp Gly Arg Arg Arg Arg Arg Arg Pro Lys
 1               5                  10                  15      
Lys Lys Arg Lys Val
            20      


<210> 39
<211> 32
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 39
Arg Arg Arg Arg Ser Arg Arg Arg Arg Arg Arg Phe Gly Arg Arg Arg
 1               5                  10                  15      
Arg Arg Arg Val Trp Arg Arg Arg Arg Pro Lys Lys Lys Arg Lys Val
            20                  25                  30          


<210> 40
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> MOD_RES        
<222> 1
<223> Xaa = D-isomer of Cys

<400> 40
Xaa Cys Ser Lys Ala Pro Lys Leu Pro Ala Ala Tyr Cys
 1               5                  10              


<210> 41
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 41
Gly Gly Gly Gly Gly Cys Ser Lys Cys
 1               5                  


<210> 42
<211> 39
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 42
Cys Thr Thr Thr His Thr Phe Val Lys Ala Leu Thr Met Asp Gly Lys
 1               5                  10                  15      
Gln Ala Ala Trp Arg Phe Ile Arg Ile Asp Thr Ala Cys Lys Lys Lys
            20                  25                  30          
Lys Lys Lys Lys Lys Lys Lys
        35                  


<210> 43
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 43
Thr Thr Ala Thr Asp Ile Lys Gly Lys Glu Val Met Val
 1               5                  10              


<210> 44
<211> 9
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 44
Glu Val Asn Ile Asn Asn Ser Val Phe
 1               5                  


<210> 45
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 45
Arg Gly Ile Asp Ser Lys His Trp Asn Ser Tyr
 1               5                  10      


<210> 46
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 46
Thr Thr Thr His Thr Phe Val Lys Ala Leu Thr Met Asp Gly Lys Gln
 1               5                  10                  15      
Ala Ala Trp Arg Phe Ile Arg Ile Asp Thr Ala
            20                  25          


<210> 47
<211> 21
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 47
Ala Leu Trp Lys Thr Leu Leu Lys Lys Val Leu Lys Ala Pro Lys Lys
 1               5                  10                  15      
Lys Arg Lys Val Cys
            20      


<210> 48
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 48
Val Arg Leu Pro Pro Pro Val Arg Leu Pro Pro Pro Val Arg Leu Pro
 1               5                  10                  15      
Pro Pro
        


<210> 49
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 49
Leu Gly Thr Tyr Thr Gln Asp Phe Asn Lys Phe His Thr Phe Pro Gln
 1               5                  10                  15      
Thr Ala Ile Gly Val Gly Ala Pro
            20                  


<210> 50
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 50
Met Val Thr Val Leu Phe Arg Arg Leu Arg Ile Arg Arg Ala Cys Gly
 1               5                  10                  15      
Pro Pro Arg Val Arg Val
            20          


<210> 51
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 51
Met Val Arg Arg Phe Leu Val Thr Leu Arg Ile Arg Arg Ala Cys Gly
 1               5                  10                  15      
Pro Pro Arg Val Arg Val
            20          


<210> 52
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 52
Phe Val Thr Arg Gly Cys Pro Arg Arg Leu Val Ala Arg Leu Ile Arg
 1               5                  10                  15      
Val Met Val Pro Arg Arg
            20          


<210> 53
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 53
Ala Ala Val Ala Leu Leu Pro Ala Val Leu Leu Ala Leu Leu Ala Pro
 1               5                  10                  15      


<210> 54
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 54
Ala Ala Val Leu Leu Pro Val Leu Leu Pro Val Leu Leu Ala Ala Pro
 1               5                  10                  15      


<210> 55
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 55
Val Thr Val Leu Ala Leu Gly Ala Leu Ala Gly Val Gly Val Gly
 1               5                  10                  15  


<210> 56
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 56
Gly Ala Leu Phe Leu Gly Trp Leu Gly Ala Ala Gly Ser Thr Met Gly
 1               5                  10                  15      
Ala
    


<210> 57
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 57
Met Gly Leu Gly Leu His Leu Leu Val Leu Ala Ala Ala Leu Gln
 1               5                  10                  15  


<210> 58
<211> 27
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 58
Met Gly Leu Gly Leu His Leu Leu Val Leu Ala Ala Ala Leu Gln Gly
 1               5                  10                  15      
Ala Trp Ser Gln Pro Lys Lys Lys Arg Lys Val
            20                  25          


<210> 59
<211> 24
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 59
Leu Gly Thr Tyr Thr Gln Asp Phe Asn Lys Phe His Thr Phe Pro Gln
 1               5                  10                  15      
Thr Ala Ile Gly Val Gly Ala Pro
            20                  


<210> 60
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 60
Thr Pro Pro Lys Lys Lys Arg Lys Val Glu Asp Pro Lys Lys Lys Lys
 1               5                  10                  15      


<210> 61
<211> 37
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 61
Leu Leu Gly Asp Phe Phe Arg Lys Ser Lys Glu Lys Ile Gly Lys Glu
 1               5                  10                  15      
Phe Lys Arg Ile Val Gln Arg Ile Lys Asp Phe Leu Arg Asn Leu Val
            20                  25                  30          
Pro Arg Thr Glu Ser
        35          


<210> 62
<211> 13
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 62
Ala Leu Trp Lys Thr Leu Leu Lys Lys Val Leu Lys Ala
 1               5                  10              


<210> 63
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 63
Ala Leu Trp Lys Thr Leu Leu Lys Lys Val Leu Lys Ala Pro Lys Lys
 1               5                  10                  15      
Lys Arg Lys Val
            20  


<210> 64
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 64
Pro Lys Lys Lys Arg Lys Val Ala Leu Trp Lys Thr Leu Leu Lys Lys
 1               5                  10                  15      
Val Leu Lys Ala
            20  


<210> 65
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 65
Arg Gln Ala Arg Arg Asn Arg Arg Arg Ala Leu Trp Lys Thr Leu Leu
 1               5                  10                  15      
Lys Lys Val Leu Lys Ala
            20          


<210> 66
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 66
Ile Val Ile Ala Lys Leu Lys Ala
 1               5              


<210> 67
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 67
Ile Val Ile Ala Lys Leu Lys Ala Asn Leu Met Cys Lys Thr Cys Arg
 1               5                  10                  15      
Leu Ala Lys
            


<210> 68
<211> 5
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 68
Lys Val Lys Lys Gln
 1               5  


<210> 69
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> MOD_RES        
<222> (1)...(16)
<223> D-amino acids

<400> 69
Ala Ala Lys Lys Ala Ala Lys Lys Ala Ala Lys Lys Ala Ala Lys Lys
 1               5                  10                  15      


<210> 70
<211> 6
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 70
Pro Phe Val Tyr Leu Ile
 1               5      


<210> 71
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 71
Cys Ser Ile Pro Pro Glu Val Lys Phe Asn Lys Pro Phe Val Tyr Leu
 1               5                  10                  15      
Ile
    


<210> 72
<211> 23
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> VARIANT        
<222> 1-3, 8-13, 16, 21-23
<223> Xaa = any or no amino acid

<400> 72
Xaa Xaa Xaa Lys Lys Arg Arg Xaa Xaa Xaa Xaa Xaa Xaa Thr Trp Xaa
 1               5                  10                  15      
Glu Thr Trp Trp Xaa Xaa Xaa
            20              


<210> 73
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> VARIANT        
<222> 8, 9, 11-13, 16
<223> Xaa = any or no amino acid

<400> 73
Tyr Gly Phe Lys Lys Arg Arg Xaa Xaa Gln Xaa Xaa Xaa Thr Trp Xaa
 1               5                  10                  15      
Glu Thr Trp Trp Thr Glu
            20          


<210> 74
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> VARIANT        
<222> 6, 20
<223> Xaa = any or no amino acid

<400> 74
Tyr Gly Phe Lys Lys Xaa Arg Arg Pro Trp Thr Trp Trp Glu Thr Trp
 1               5                  10                  15      
Trp Thr Glu Xaa
            20  


<210> 75
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> VARIANT        
<222> 1, 2, 5, 7
<223> Xaa = hydrophobic amino acid

<220> 
<221> VARIANT        
<222> 3, 4, 6
<223> Xaa = basic amino acid

<220> 
<221> VARIANT        
<222> 1-7
<223> amino acids 1-7 are optionally repeated 1 to 9
      times

<400> 75
Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5          


<210> 76
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = any amino acid

<220> 
<221> VARIANT        
<222> 2, 3, 6, 10, 13, 14
<223> Xaa = D or L lysine, histidine, homolysine,
      diaminobutyric acid, arginine, ornithine, or
      homoarginine

<220> 
<221> VARIANT        
<222> 4, 5, 8, 12
<223> Xaa = D or L alanine, valine, leucine,
      isolecucine, phenylalanine, tyrosine, tryptophan,
      cysteine, or methionine

<220> 
<221> VARIANT        
<222> 7, 9, 11
<223> Xaa = D or L Lys, His, homolysine, diaminobutyric 
      acid, Arg, ornithine, homoarginine, Ala, Val, Leu,
      Ile, Phe, Tyr, Trp, Cys, Met, Gly, Ser, Thr,
      aspartate, glutamate, Asn, or Gln

<400> 76
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5                  10                  


<210> 77
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> VARIANT        
<222> 14
<223> Xaa = any amino acid

<220> 
<221> VARIANT        
<222> 1, 2, 5, 9, 12, 13
<223> Xaa = D or L lysine, histidine, homolysine,
      diaminobutyric acid, arginine, ornithine, or
      homoarginine

<220> 
<221> VARIANT        
<222> 3, 7, 10, 11
<223> Xaa = D or L alanine, valine, leucine,
      isolecucine, phenylalanine, tyrosine, tryptophan,
      cysteine, or methionine

<220> 
<221> VARIANT        
<222> 4, 6, 8
<223> Xaa = D or L Lys, His, homolysine, diaminobutyric 
      acid, Arg, ornithine, homoarginine, Ala, Val, Leu,
      Ile, Phe, Tyr, Trp, Cys, Met, Gly, Ser, Thr,
      aspartate, glutamate, Asn, or Gln

<400> 77
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5                  10                  


<210> 78
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> VARIANT        
<222> 1
<223> Xaa = an amino acid exhibiting relatively high
      rotation freedom of a peptide unit (e.g., G or A)

<220> 
<221> VARIANT        
<222> 4
<223> Xaa = basic amino acid

<220> 
<221> VARIANT        
<222> 2-10
<223> Xaa = any amino acid except that at least three
      are R or K

<400> 78
Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa
 1               5                  10  


<210> 79
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 79
Tyr Gly Arg Arg Ala Arg Arg Arg Arg Arg Arg
 1               5                  10      


<210> 80
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 80
Tyr Gly Arg Arg Ala Arg Arg Arg Ala Arg Arg
 1               5                  10      


<210> 81
<211> 11
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 81
Tyr Gly Arg Arg Arg Arg Arg Arg Arg Arg Arg
 1               5                  10      


<210> 82
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 82
His Ala Ile Tyr Pro Arg His
 1               5          


<210> 83
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 83
Thr His Arg Pro Pro Met Trp Ser Pro Val Trp Pro
 1               5                  10          


<210> 84
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> VARIANT        
<222> 3
<223> Xaa = D-threonine

<400> 84
Gly Phe Xaa Thr Gly Phe Leu Ser
 1               5              


<210> 85
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> VARIANT        
<222> 2
<223> Xaa = D or L phenylalanine

<400> 85
Gly Xaa Thr Gly Phe Leu Ser
 1               5          


<210> 86
<211> 29
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 86
Tyr Thr Ile Trp Met Pro Glu Asn Pro Arg Pro Gly Thr Pro Cys Asp
 1               5                  10                  15      
Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Asn Gly
            20                  25                  


<210> 87
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 87
Gly Gly Gly Val Phe Trp Gln
 1               5          


<210> 88
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 88
His Gly Arg Val Arg Pro His
 1               5          


<210> 89
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 89
Val Val Leu Val Thr Ser Ser
 1               5          


<210> 90
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 90
Cys Leu His Arg Gly Asn Ser Cys
 1               5              


<210> 91
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 91
Cys Arg Ser Trp Asn Lys Ala Asp Asn Arg Ser Cys
 1               5                  10          


<210> 92
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 92
Cys Arg Ser Trp Asn Lys Ala Asp Asn Arg Ser Cys
 1               5                  10          


<210> 93
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 93
Leu Ser Ile Pro Pro Lys Ala
 1               5          


<210> 94
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 94
Phe Gln Thr Pro Pro Gln Leu
 1               5          


<210> 95
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 95
Leu Thr Pro Ala Thr Ala Ile
 1               5          


<210> 96
<211> 35
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 96
Gly Gly Gly Ala Arg Lys Lys Ala Ala Lys Ala Ala Arg Lys Lys Ala
 1               5                  10                  15      
Ala Lys Ala Ala Arg Lys Lys Ala Ala Lys Ala Ala Arg Lys Lys Ala
            20                  25                  30          
Ala Lys Ala
        35  


<210> 97
<211> 22
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 97
Arg Ser Gln Ser Arg Ser Arg Tyr Tyr Arg Gln Arg Gln Arg Ser Arg
 1               5                  10                  15      
Arg Arg Arg Arg Arg Ser
            20          


<210> 98
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 98
Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Glu Asn Gly Trp Glu Gly
 1               5                  10                  15      


<210> 99
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> VARIANT        
<222> 12
<223> Xaa = Asn or Gly

<220> 
<221> VARIANT        
<222> 18
<223> Xaa = Ile or Val

<400> 99
Gly Leu Phe Gly Ala Ile Ala Gly Phe Ile Gly Xaa Gly Trp Gly Gly
 1               5                  10                  15      
Met Xaa Asp
            


<210> 100
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 100
Gly Asp Ile Met Gly Glu Trp Gly Asn Glu Ile Phe Gly Ala Ile Ala
 1               5                  10                  15      
Gly Phe Leu Gly
            20  


<210> 101
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 101
Arg Arg Arg Gln Arg Arg Lys Lys Arg Gly Gly Asp Ile Met Gly Glu
 1               5                  10                  15      
Trp Gly Asn Glu Ile Phe Gly Ala Ile Ala Gly Phe Leu Gly
            20                  25                  30  


<210> 102
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 102
Cys His Lys Lys Lys Lys Lys Lys His Cys
 1               5                  10  


<210> 103
<211> 17
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 103
Cys His His His His His His Lys Lys Lys His His His His His His
 1               5                  10                  15      
Cys
    


<210> 104
<211> 8
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 104
His His His His His Trp Tyr Gly
 1               5              


<210> 105
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 105
Phe Phe Gly Ala Val Ile Gly Thr Ile Ala Leu Gly Val Ala Thr Ala
 1               5                  10                  15      


<210> 106
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 106
Phe Leu Gly Phe Leu Leu Gly Val Gly Ser Ala Ile Ala Ser Gly Val
 1               5                  10                  15      


<210> 107
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 107
Gly Val Phe Val Leu Gly Phe Leu Gly Phe Leu Ala Thr Ala Gly Ser
 1               5                  10                  15      


<210> 108
<211> 16
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 108
Gly Ala Ala Ile Gly Leu Ala Trp Ile Pro Tyr Phe Gly Pro Ala Ala
 1               5                  10                  15      


<210> 109
<211> 26
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 109
Gly Ile Gly Ala Val Leu Lys Val Leu Thr Thr Gly Leu Pro Ala Leu
 1               5                  10                  15      
Ile Ser Trp Ile Lys Arg Lys Arg Gln Gln
            20                  25      


<210> 110
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 110
Glu Ala Leu Ala
 1              


<210> 111
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 111
Gly Ala Leu Ala
 1              


<210> 112
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 112
Trp Glu Ala Ala Leu Ala Glu Ala Leu Ala Glu Ala Leu Ala Glu His
 1               5                  10                  15      
Leu Ala Glu Ala Leu Ala Glu Ala Leu Glu Ala Leu Ala Ala
            20                  25                  30  


<210> 113
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 113
Lys Ala Leu Ala
 1              


<210> 114
<211> 30
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 114
Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala Leu Ala Lys His
 1               5                  10                  15      
Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Ala Cys Glu Ala
            20                  25                  30  


<210> 115
<211> 4
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 115
Glu Gly Leu Ala
 1              


<210> 116
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 116
Gly Leu Phe Glu Ala Leu Leu Glu Leu Leu Glu Ser Leu Trp Glu Leu
 1               5                  10                  15      
Leu Leu Glu Ala
            20  


<210> 117
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 117
Gly Leu Phe Lys Ala Leu Leu Lys Leu Leu Lys Ser Leu Trp Lys Leu
 1               5                  10                  15      
Leu Leu Lys Ala
            20  


<210> 118
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<400> 118
Gly Leu Phe Arg Ala Leu Leu Arg Leu Leu Arg Ser Leu Trp Arg Leu
 1               5                  10                  15      
Leu Leu Arg Ala
            20  


<210> 119
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 10-11, 12-20 
<223> phosphorothioate linkage

<400> 119
cagaccuaug gaaacuacuu                                             20

<210> 120
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 12-20 
<223> phosphorothioate linkage

<400> 120
aaguaguuuc cauaggucug                                             20

<210> 121
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 10-11, 12-20 
<223> phosphorothioate linkage

<400> 121
ccgucccaag caauggacga                                             20

<210> 122
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-9, 21-13, 14-20 
<223> phosphorothioate linkage

<400> 122
ucguccauug cuugggacgg                                             20

<210> 123
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-15 
<223> phosphorothioate linkage

<400> 123
gucccaagca augga                                                  15

<210> 124
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15, 17
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18, 19, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-9, 12-13, 14-20 
<223> phosphorothioate linkage

<400> 124
ucguccauug cuugggacgg                                             20

<210> 125
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-10, 11-18 
<223> phosphorothioate linkage

<400> 125
ccgaguggaa ggaaauuu                                               18

<210> 126
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 12-18 
<223> phosphorothioate linkage

<400> 126
aaauuuccuu ccacucgg                                               18

<210> 127
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-10, 11-18 
<223> phosphorothioate linkage

<400> 127
ggagaauauu ucacccuu                                               18

<210> 128
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 12-18 
<223> phosphorothioate linkage

<400> 128
aagggugaaa uauucucc                                               18

<210> 129
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-21 
<223> phosphorothioate linkage

<400> 129
ggagggagaa uauuucaccc u                                           21

<210> 130
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-9, 12-13, 14-22 
<223> phosphorothioate linkage

<400> 130
gagggugaaa uauucucccu cc                                          22

<210> 131
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-10, 11-20 
<223> phosphorothioate linkage

<400> 131
ggacggaaca gcuuugaggu                                             20

<210> 132
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 12-20 
<223> phosphorothioate linkage

<400> 132
accucaaagc uguuccgucc                                             20

<210> 133
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 4, 7, 9, 11, 15
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 3, 5, 6, 8, 10, 12, 13, 14, 16
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-16 
<223> phosphorothioate linkage

<400> 133
guucaagaca gaaggg                                                 16

<210> 134
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 6, 7, 9, 11, 13, 14, 16, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 4, 5, 8, 10, 12, 15, 17, 18, 20, 21
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 12-21 
<223> phosphorothioate linkage

<400> 134
ggcccuucug ucuugaacau g                                           21

<210> 135
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-20 
<223> phosphorothioate linkage

<400> 135
ggaagacugu uacuacagtt                                             20

<210> 136
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 12-20 
<223> phosphorothioate linkage

<400> 136
aacuguagua acagucuucc                                             20

<210> 137
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 10-11, 12-21 
<223> phosphorothioate linkage

<400> 137
ggaagacugu uacuacagtc t                                           21

<210> 138
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19, 21
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 9-10, 13-14, 15-21 
<223> phosphorothioate linkage
<400> 138
agacuguagu aacagucuuc c                                           21

<210> 139
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-10, 11-20 
<223> phosphorothioate linkage

<400> 139
gugaugaagg acauggcuua                                             20

<210> 140
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 12-20 
<223> phosphorothioate linkage

<400> 140
uaagccaugu ccuucaucac                                             20

<210> 141
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-10, 11-20 
<223> phosphorothioate linkage

<400> 141
gccaugaagg acauggcuua                                             20

<210> 142
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-9, 12-13, 14-20 
<223> phosphorothioate linkage

<400> 142
uaagccaugu ccuucauggc                                             20

<210> 143
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 3, 5, 7, 9, 10, 11, 13, 15, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-10, 11-20 
<223> phosphorothioate linkage

<400> 143
gaagcguaug acacauugat                                             20

<210> 144
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 12-20 
<223> phosphorothioate linkage

<400> 144
aucaaugugu cauacgcuuc                                             20

<210> 145
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-10, 11-19 
<223> phosphorothioate linkage

<400> 145
ggacauuacu agugacuca                                              19

<210> 146
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 12-19 
<223> phosphorothioate linkage

<400> 146
ugagucacua guaaugucc                                              19

<210> 147
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-10, 11-12, 13-21 
<223> phosphorothioate linkage

<400> 147
gucaucacac ugaauaccaa u                                           21

<210> 148
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-10, 13-21 
<223> phosphorothioate linkage

<400> 148
auugguauuc agugugauga c                                           21

<210> 149
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 5, 7, 9, 11, 13, 16, 18, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 4, 14, 15, 17
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 10-11, 21-19 
<223> phosphorothioate linkage

<400> 149
gguguauggc uucaacccu                                              19

<210> 150
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 3, 6, 8, 10, 12, 14, 16
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 4, 5, 7, 9, 11, 13, 15, 17, 18, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 12-19 
<223> phosphorothioate linkage

<400> 150
aggguugaag ccauacacc                                              19

<210> 151
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 7, 9, 11, 13, 15, 18, 20, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 6, 16, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 10-11, 12-13, 14-21 
<223> phosphorothioate linkage

<400> 151
aggguguaug gcuucaaccc u                                           21

<210> 152
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 3, 6, 8, 10, 12, 14, 16
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 4, 5, 7, 9, 11, 13, 15, 17, 18, 19, 20, 21
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-9, 12-13, 14-21 
<223> phosphorothioate linkage

<400> 152
aggguugaag ccauacaccc u                                           21

<210> 153
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 15, 17, 19, 21, 23
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 9-10, 11-13, 14-23 
<223> phosphorothioate linkage

<400> 153
ggaguuugug acaaauaugg gca                                         23

<210> 154
<211> 23
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 23
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 12-23
<223> phosphorothioate linkage

<400> 154
ugcccauauu ugucacaaac ucc                                         23

<210> 155
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 6, 8, 10, 12, 14, 16, 18, 19, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 5, 7, 9, 11, 13, 15, 17
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-10, 11-12, 13-20 
<223> phosphorothioate linkage

<400> 155
gauugauuga ccuguccauu                                             20

<210> 156
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 12, 14, 16
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15, 17, 18, 19, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 12-20
<223> phosphorothioate linkage

<400> 156
aauggacagg ucaaucaauc                                             20

<210> 157
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-10, 11-21 
<223> phosphorothioate linkage

<400> 157
gucaucacac ugaauaccaa u                                           21

<210> 158
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 19, 21
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 12-21
<223> phosphorothioate linkage

<400> 158
auugguauuc agugugauga c                                           21

<210> 159
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 11-21
<223> phosphorothioate linkage

<400> 159
guauucacac ugaauaccaa u                                           21

<210> 160
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-9, 12-13, 14-21
<223> phosphorothioate linkage

<400> 160
auugguauuc agugugaaua c                                           21

<210> 161
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-10, 11-22 
<223> phosphorothioate linkage

<400> 161
ggugcgaagc agacugaggc ta                                          22

<210> 162
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 12-22 
<223> phosphorothioate linkage

<400> 162
tagccucagu cugcuucgca cc                                          22

<210> 163
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-15 
<223> phosphorothioate linkage

<400> 163
ugcgaagcag acuga                                                  15

<210> 164
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7--9, 12-13, 14-21 
<223> phosphorothioate linkage

<400> 164
gccucagucu gcuucgcagg c                                           21

<210> 165
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-19 
<223> phosphorothioate linkage

<400> 165
cggcauucgg cuauguguu                                              19

<210> 166
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 2, 3, 5, 7, 9, 11, 13, 15, 17
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 4, 6, 8, 10, 12, 14, 16, 18, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 21-19 
<223> phosphorothioate linkage

<400> 166
aacacauagc cgaaugccg                                              19

<210> 167
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-15 
<223> phosphorothioate linkage

<400> 167
cacagggcuc acccu                                                  15

<210> 168
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 4, 6, 8, 10, 12, 14
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 3, 5, 7, 13, 15, 16, 17, 18, 19, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-9, 12-13, 14-20 
<223> phosphorothioate linkage

<400> 168
ucagggugag cccugugugu                                             20

<210> 169
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-10, 11-19 
<223> phosphorothioate linkage

<400> 169
gccuggaguu uauucggaa                                              19

<210> 170
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 12-19 
<223> phosphorothioate linkage

<400> 170
uuccgaauaa acuccaggc                                              19

<210> 171
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-10, 11-18 
<223> phosphorothioate linkage

<400> 171
cuagaccugu uuugcuuu                                               18

<210> 172
<211> 18
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 12-18 
<223> phosphorothioate linkage

<400> 172
aaagcaaaac aggucuag                                               18

<210> 173
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15, 18, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 17
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 10-19 
<223> phosphorothioate linkage

<400> 173
gagguguauc uccuagaca                                              19

<210> 174
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 6, 16, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 12-19 
<223> phosphorothioate linkage

<400> 174
ugucuaggag auacaccuc                                              19

<210> 175
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15, 18, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 17
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 10-19 
<223> phosphorothioate linkage

<400> 175
gagguguauc uccucgaca                                              19

<210> 176
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 12-19 
<223> phosphorothioate linkage

<400> 176
ugucgaggag auacaccuc                                              19

<210> 177
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15, 18, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 17
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 9-10, 11-19 
<223> phosphorothioate linkage

<400> 177
gagguguauc uccucgaca                                              19

<210> 178
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-9, 12-13, 14-19 
<223> phosphorothioate linkage

<400> 178
ugucgaggag auacaccuc                                              19

<210> 179
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-10, 11-20 
<223> phosphorothioate linkage

<400> 179
ggguggucag cggccgggau                                             20

<210> 180
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 2, 3, 5, 7, 9, 11, 13, 15, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 4, 6, 8, 10, 12, 14, 16, 17, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 21-20 
<223> phosphorothioate linkage

<400> 180
aucccggccg cugaccaccc                                             20

<210> 181
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 13, 15, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 11, 12, 14, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-20 
<223> phosphorothioate linkage

<400> 181
ggguggucag cggccgggau                                             20

<210> 182
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 17, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 12-20 
<223> phosphorothioate linkage

<400> 182
aucccggccg cugaccaccc                                             20

<210> 183
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 4, 6, 8, 10, 12
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 3, 5, 7, 9, 11, 13, 14, 15
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-15 
<223> phosphorothioate linkage

<400> 183
uggucagcgg ccggg                                                  15

<210> 184
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 5, 7, 9, 11, 13, 15
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 3, 4, 6, 8, 10, 12, 14, 16, 17, 18, 19, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 12-20 
<223> phosphorothioate linkage

<400> 184
aucccggccg cugaccaccc                                             20

<210> 185
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 13, 14, 15
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-15 
<223> phosphorothioate linkage

<400> 185
guggucagcg gccgg                                                  15

<210> 186
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 6, 8, 10, 12, 14
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 3, 4, 5, 7, 9, 11, 13, 15, 16, 17, 18, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-10, 13-19
<223> phosphorothioate linkage

<400> 186
acccggccgc ugaccaccc                                              19

<210> 187
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 9-10, 11-12, 13-20 
<223> phosphorothioate linkage

<400> 187
gcugcccacg uggcuggcau                                             20

<210> 188
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 19, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-9, 12-13, 14-20
<223> phosphorothioate linkage

<400> 188
augccagcca cgugggcagc                                             20

<210> 189
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 4, 6, 8, 10, 14, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 9-10, 11-12, 13-20 
<223> phosphorothioate linkage

<400> 189
gcugcccacg uggcuggcau                                             20

<210> 190
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18, 19, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-9, 12-13, 14-20 
<223> phosphorothioate linkage

<400> 190
augccagcca cgugggcagc                                             20

<210> 191
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 5, 7, 9, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 4, 6, 8, 10, 11, 12, 14, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-20 
<223> phosphorothioate linkage

<400> 191
gcugcccacg uggcuggcau                                             20

<210> 192
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15, 17
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18, 19, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-9, 12-13, 14-20 
<223> phosphorothioate linkage

<400> 192
augccagcca cgugggcagc                                             20

<210> 193
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-5, 6-7, 8-9, 10-15 
<223> phosphorothioate linkage

<400> 193
gcccacgugg cuggc                                                  15

<210> 194
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 19, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-9, 12-13, 14-20 
<223> phosphorothioate linkage

<400> 194
augccagcca cgugggcagc                                             20

<210> 195
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 5, 7, 9, 11, 12, 14
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 6, 8, 10, 13, 15
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-15 
<223> phosphorothioate linkage

<400> 195
gcugcccacg uggcu                                                  15

<210> 196
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 8, 10, 12, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 14, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-9, 12-13, 14-20 
<223> phosphorothioate linkage

<400> 196
ccagccacgu gggcagcagc                                             20

<210> 197
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 6, 8, 10
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 3, 4, 5, 7, 9, 11, 12, 13, 14, 15
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-14 
<223> phosphorothioate linkage

<400> 197
ggugaggugu cuac                                                   14

<210> 198
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 6, 8, 10, 12, 14, 16
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 3, 4, 5, 7, 9, 11, 13, 15, 18, 19, 20, 21
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-9, 12-13, 14-21 
<223> phosphorothioate linkage

<400> 198
ggcguagaca cccucaccgc c                                           21

<210> 199
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 19, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 10-11, 12-20 
<223> phosphorothioate linkage

<400> 199
cguuagcaga aacaaaagga                                             20

<210> 200
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 12-20 
<223> phosphorothioate linkage

<400> 200
uccuuuuguu ucugcuaacg                                             20

<210> 201
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 9-15 
<223> phosphorothioate linkage

<400> 201
guaaggacca gagac                                                  15

<210> 202
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 12-19 
<223> phosphorothioate linkage

<400> 202
uugucucugg uccuuacuu                                              19

<210> 203
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-9, 10-11, 12-19 
<223> phosphorothioate linkage

<400> 203
ggguaaauac auucuucau                                              19

<210> 204
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-5, 6-7, 8-9, 12-13, 14-19 
<223> phosphorothioate linkage

<400> 204
augaagaaug uauuuaccc                                              19

<210> 205
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-5, 6-7, 8-9, 10-15 
<223> phosphorothioate linkage

<400> 205
gaaaauacau ucuuc                                                  15

<210> 206
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-5, 6-7, 8-9, 12-13, 14-19 
<223> phosphorothioate linkage

<400> 206
gggaagaaug uauuuuccc                                              19

<210> 207
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 14-19 
<223> phosphorothioate linkage

<400> 207
ggguaaauac auucuucau                                              19

<210> 208
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 14-19 
<223> phosphorothioate linkage

<400> 208
augaagaaug uauuuaccc                                              19

<210> 209
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 12-19 
<223> phosphorothioate linkage

<400> 209
ggguaaauac auucuucau                                              19

<210> 210
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 12-19 
<223> phosphorothioate linkage

<400> 210
augaagaaug uauuuaccc                                              19

<210> 211
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-3, 7-8, 12-13, 16-19 
<223> phosphorothioate linkage

<400> 211
ggguaaauac auucuucau                                              19

<210> 212
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-4, 7-8, 12-13, 16-19 
<223> phosphorothioate linkage

<400> 212
augaagaaug uauuuaccc                                              19

<210> 213
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-9, 10-11, 12-19 
<223> phosphorothioate linkage

<400> 213
ggguaaauac auucuucau                                              19

<210> 214
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-5, 6-7, 8-9, 12-13, 14-19 
<223> phosphorothioate linkage

<400> 214
augaagaaug uauuuaccc                                              19

<210> 215
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 12-19 
<223> phosphorothioate linkage

<400> 215
ggguaaauac guucuucau                                              19

<210> 216
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 12-19 
<223> phosphorothioate linkage

<400> 216
augaagaacg uauuuaccc                                              19

<210> 217
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-9, 10-19 
<223> phosphorothioate linkage

<400> 217
ggguaaauac guucuucau                                              19

<210> 218
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-5, 6-7, 8-9, 12-13, 14-19 
<223> phosphorothioate linkage

<400> 218
augaagaacg uauuuaccc                                              19

<210> 219
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 14-19 
<223> phosphorothioate linkage

<400> 219
ggguaaauac guucuucau                                              19

<210> 220
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 14-19 
<223> phosphorothioate linkage

<400> 220
augaagaacg uauuuaccc                                              19

<210> 221
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-4, 7-8, 12-13, 16-19 
<223> phosphorothioate linkage

<400> 221
ggguaaauac guucuucau                                              19

<210> 222
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-4, 7-8, 12-13, 16-19 
<223> phosphorothioate linkage

<400> 222
augaagaacg uauuuaccc                                              19

<210> 223
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 3, 4, 9, 10, 11, 13, 14, 15
<223> 2'-O-methyl nucleoside

<400> 223
gccuggaguu uauucggaa                                              19

<210> 224
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 8, 15
<223> 2'-O-methyl nucleoside

<400> 224
uuccgaauaa acuccaggc                                              19

<210> 225
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 3, 4, 9, 10, 11, 13, 14, 15, 16, 17, 18, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 5, 12
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 14-19 
<223> phosphorothioate linkage

<400> 225
gccuggaguu uauucggaa                                              19

<210> 226
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 8, 15, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 3, 4, 16, 17, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 14-19 
<223> phosphorothioate linkage

<400> 226
uuccgaauaa acuccaggc                                              19

<210> 227
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 3, 4, 9, 10, 11, 13, 14, 15, 16, 17, 18, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 5, 12
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 12-19 
<223> phosphorothioate linkage

<400> 227
gccuggaguu uauucggaa                                              19

<210> 228
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 8, 15, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 3, 4, 16, 17, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 12-19 
<223> phosphorothioate linkage

<400> 228
uuccgaauaa acuccaggc                                              19

<210> 229
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 3, 4, 5, 7, 9, 11, 13, 15, 16, 17, 18, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 6, 8, 10, 12, 14
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 14-19 
<223> phosphorothioate linkage

<400> 229
gccuggaguu uauucggaa                                              19

<210> 230
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 6, 8, 10, 12, 14, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 3, 4, 5, 15, 16, 17, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 14-19 
<223> phosphorothioate linkage

<400> 230
uuccgaauaa acuccaggc                                              19

<210> 231
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 3, 4, 5, 7, 9, 11, 13, 15, 16, 17, 18, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 6, 8, 10, 12, 14
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 8-9, 12-13, 14-19 
<223> phosphorothioate linkage

<400> 231
gccuggaguu uauucggaa                                              19

<210> 232
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 6, 8, 10, 12, 14, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 3, 4, 5, 15, 16, 17, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 11-12, 14-19 
<223> phosphorothioate linkage

<400> 232
uuccgaauaa acuccaggc                                              19

<210> 233
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 3, 4, 5, 7, 9, 11, 13, 15, 16, 17, 18, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 6, 8, 10, 12, 14
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 8-9, 12-13, 14-19 
<223> phosphorothioate linkage

<400> 233
gccuggaguu uauucggaa                                              19

<210> 234
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 6, 8, 10, 12, 14, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 3, 4, 5, 7, 9, 11, 13, 15, 16, 17, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 11-12, 14-19 
<223> phosphorothioate linkage

<400> 234
uuccgaauaa acuccaggc                                              19

<210> 235
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 8-9, 12-13, 14-19 
<223> phosphorothioate linkage

<400> 235
gccuggaguu uauucggaa                                              19

<210> 236
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-5, 7-8, 11-12, 14-19 
<223> phosphorothioate linkage

<400> 236
uuccgaauaa acuccaggc                                              19

<210> 237
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-10, 11-13, 14-19 
<223> phosphorothioate linkage

<400> 237
gccuggaguu uauucggaa                                              19

<210> 238
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 12-19 
<223> phosphorothioate linkage

<400> 238
uuccgaauaa acuccaggc                                              19

<210> 239
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 11-12, 13-19 
<223> phosphorothioate linkage

<400> 239
gaagcccaga ggagcuaua                                              19

<210> 240
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 16, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 13, 15, 17, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 12-13, 14-19 
<223> phosphorothioate linkage

<400> 240
uauagcuccu cugggcuuc                                              19

<210> 241
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 11-12, 13-19 
<223> phosphorothioate linkage

<400> 241
gaagcccaga ggagcuaua                                              19

<210> 242
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 16, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 14-19 
<223> phosphorothioate linkage

<400> 242
uauagcuccu cugggcuuc                                              19

<210> 243
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 11-12, 13-19 
<223> phosphorothioate linkage

<400> 243
gaagcccaga ggagcuaua                                              19

<210> 244
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 14, 16, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 8, 10, 12, 15, 17, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 14-19 
<223> phosphorothioate linkage

<400> 244
uauagcuccu cugggcuuc                                              19

<210> 245
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 11-12, 13-19 
<223> phosphorothioate linkage

<400> 245
gaagcccaga ggagcuaua                                              19

<210> 246
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 14-19 
<223> phosphorothioate linkage

<400> 246
uauagcuccu cugggcuuc                                              19

<210> 247
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 11-19 
<223> phosphorothioate linkage

<400> 247
gaagcccaga ggagcuaua                                              19

<210> 248
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 12-13, 14-19 
<223> phosphorothioate linkage

<400> 248
uauagcuccu cugggcuuc                                              19

<210> 249
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 11-19 
<223> phosphorothioate linkage

<400> 249
gaagcccaga ggagcuaua                                              19

<210> 250
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 12-13, 14-19 
<223> phosphorothioate linkage

<400> 250
uauagcuccu cugggcuuc                                              19

<210> 251
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 5, 7, 9, 11, 13, 15, 16, 17, 18, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 3, 4, 6, 8, 10, 12, 14
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 11-19 
<223> phosphorothioate linkage

<400> 251
gaagcccaga ggagcuaua                                              19

<210> 252
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 2, 3, 4, 6, 8, 10, 12, 14, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 5, 7, 9, 11, 13, 15, 16, 17, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 12-13, 14-19 
<223> phosphorothioate linkage

<400> 252
uauagcuccu cugggcuuc                                              19

<210> 253
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 2, 7, 8, 9, 15, 16
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 9-10, 11-12, 13-19 
<223> phosphorothioate linkage

<400> 253
ucaaaguccg agagucagg                                              19

<210> 254
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 4, 5, 11, 12, 13, 18, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 3, 6, 7, 8, 9, 10, 14, 15, 16, 17
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 14-19 
<223> phosphorothioate linkage

<400> 254
ccugacucuc ggacuuuga                                              19

<210> 255
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 15, 16
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-16 
<223> phosphorothioate linkage

<400> 255
cggcauucgg cuaugu                                                 16


<210> 256
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 2, 7, 8, 9, 15, 16
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 9-10, 11-12, 13-19 
<223> phosphorothioate linkage

<400> 256
ucaaaguccg agagucagg                                              19

<210> 257
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 4, 5, 11, 12, 13, 18, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 3, 6, 7, 8, 9, 10, 14, 15, 16, 17
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 12-19 
<223> phosphorothioate linkage

<400> 257
ccugacucuc ggacuuuga                                              19

<210> 258
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 10-11, 13-19 
<223> phosphorothioate linkage

<400> 258
ucaaaguccg agagucagg                                              19

<210> 259
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 12-13, 14-19 
<223> phosphorothioate linkage

<400> 259
ccugacucuc ggacuuuga                                              19

<210> 260
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 2, 3, 5, 7, 9, 11, 13, 15, 17
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 4, 6, 8, 10, 12, 14, 16, 18, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 10-11, 13-19 
<223> phosphorothioate linkage

<400> 260
ucaaaguccg agagucagg                                              19

<210> 261
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 12-13, 14-19 
<223> phosphorothioate linkage

<400> 261
ccugacucuc ggacuuuga                                              19

<210> 262
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 5, 7, 9, 11, 13, 15, 17, 18, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 6, 8, 10, 12, 14, 16, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 8-9, 12-13, 14-20 
<223> phosphorothioate linkage

<400> 262
uggaggagcc gcagucagau                                             20

<210> 263
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 2, 3, 5, 7, 13, 15, 18, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 4, 6, 8, 10, 12, 14, 16, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 15-20 
<223> phosphorothioate linkage

<400> 263
aucugacugc ggcuccucca                                             20

<210> 264
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 5, 7, 9, 11, 13, 15, 17, 18, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 6, 8, 10, 12, 14, 16, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 8-9, 12-13, 15-20 
<223> phosphorothioate linkage

<400> 264
uggaggagcc gcagucagau                                             20

<210> 265
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 2, 3, 5, 7, 13, 15, 18, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 4, 6, 8, 10, 12, 14, 16, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 12-13, 15-20 
<223> phosphorothioate linkage

<400> 265
aucugacugc ggcuccucca                                             20

<210> 266
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 5, 7, 9, 11, 13, 15, 17, 18, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 6, 8, 10, 12, 14, 16, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 8-9, 12-13, 15-20 
<223> phosphorothioate linkage

<400> 266
uggaggagcc gcagucagau                                             20

<210> 267
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 2, 3, 5, 7, 13, 15, 18, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 4, 6, 8, 10, 12, 14, 16, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-9, 12-13, 14-20 
<223> phosphorothioate linkage

<400> 267
aucugacugc ggcuccucca                                             20

<210> 268
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 5, 7, 9, 11, 13, 15, 18, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 6, 8, 10, 12, 14, 16, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-20 
<223> phosphorothioate linkage

<400> 268
uggaggagcc gcagucagau                                             20

<210> 269
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 7, 13, 15, 18, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 6, 8, 10, 12, 14, 16, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-9, 12-13, 14-20 
<223> phosphorothioate linkage

<400> 269
aucugacugc ggcuccucca                                             20

<210> 270
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 5, 7, 10, 13, 15, 18, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 6, 8, 9, 11, 12, 14, 16, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-20 
<223> phosphorothioate linkage

<400> 270
uggaggagcc gcagucagau                                             20

<210> 271
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 7, 9, 13, 15, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 6, 8, 10, 12, 14, 16, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-9, 12-13, 14-20 
<223> phosphorothioate linkage

<400> 271
aucugacugc ggcuccucca                                             20

<210> 272
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 3, 5, 7, 9, 11, 13, 16
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 4, 6, 8, 10, 12, 14, 15
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 9-16 
<223> phosphorothioate linkage

<400> 272
gaggagccgc agucag                                                 16

<210> 273
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 2, 3, 4, 6, 8, 10, 12, 14, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 6, 8, 10, 12, 14, 16, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-9, 12-13, 14-20 
<223> phosphorothioate linkage

<400> 273
aucugacugc ggcuccucca                                             20

<210> 274
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 11, 13, 15, 17, 18, 19, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 10, 12, 14, 16
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 9-10, 11-12, 13-20 
<223> phosphorothioate linkage

<400> 274
auggaugauu ugaugcuguc                                             20

<210> 275
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 12, 14, 16, 18, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 13, 15, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 15-20 
<223> phosphorothioate linkage

<400> 275
gacagcauca aaucauccau                                             20

<210> 276
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 11, 13, 15, 17, 18, 19, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 10, 12, 14, 16
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 9-10, 11-12, 13-20 
<223> phosphorothioate linkage

<400> 276
auggaugauu ugaugcuguc                                             20

<210> 277
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 12, 14, 16, 18, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 13, 15, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 12-13, 15-20 
<223> phosphorothioate linkage

<400> 277
gacagcauca aaucauccau                                             20

<210> 278
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 7, 9, 11, 13, 15, 17, 18, 19, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 6, 8, 10, 12, 14, 16
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 9-10, 11-12, 13-20 
<223> phosphorothioate linkage

<400> 278
auggaugauu ugaugcuguc                                             20

<210> 279
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 16, 18, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 12-13, 15-20 
<223> phosphorothioate linkage

<400> 279
gacagcauca aaucauccau                                             20

<210> 280
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 7, 9, 11, 13, 15, 17, 18, 19, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 6, 8, 10, 12, 14, 16
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 9-10, 11-12, 13-20 
<223> phosphorothioate linkage

<400> 280
auggaugauu ugaugcuguc                                             20

<210> 281
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 16, 18, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 8-9, 12-13, 15-20 
<223> phosphorothioate linkage

<400> 281
gacagcauca aaucauccau                                             20

<210> 282
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 21, 22
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 9-10, 12-13, 14-22 
<223> phosphorothioate linkage

<400> 282
gcaauggaug auuugaugcu gu                                          22

<210> 283
<211> 22
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 13-14, 15-16, 17-22 
<223> phosphorothioate linkage

<400> 283
acagcaucaa aucauccauu gc                                          22

<210> 284
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 4, 7, 8, 10, 12, 14, 16, 18, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 10-11, 12-13, 14-20 
<223> phosphorothioate linkage

<400> 284
gcaauggaug auuugaugcu                                             20

<210> 285
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 11-12, 13-14, 15-20 
<223> phosphorothioate linkage

<400> 285
agcaucaaau cauccauugc                                             20

<210> 286
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 9-10, 13-14, 15-21 
<223> phosphorothioate linkage

<400> 286
gucaucacac ugaauaccaa u                                           21

<210> 287
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 15-21 
<223> phosphorothioate linkage

<400> 287
auugguauuc agugugauga c                                           21

<210> 288
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 9-10, 13-14, 15-21 
<223> phosphorothioate linkage

<400> 288
gucaucacac ugaauaccaa u                                           21

<210> 289
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 15-21 
<223> phosphorothioate linkage

<400> 289
auugguauuc agugugauga c                                           21

<210> 290
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 9-10, 13-14, 15-21 
<223> phosphorothioate linkage

<400> 290
gucaucacac ugaauaccaa u                                           21

<210> 291
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 15-21 
<223> phosphorothioate linkage

<400> 291
auugguauuc agugugauga c                                           21

<210> 292
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 9-10, 13-14, 15-21 
<223> phosphorothioate linkage

<400> 292
gucaucacac ugaauaccaa u                                           21

<210> 293
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-9, 13-14, 15-21 
<223> phosphorothioate linkage

<400> 293
auugguauuc agugugauga c                                           21

<210> 294
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 9-10, 13-14, 15-21 
<223> phosphorothioate linkage

<400> 294
gucaucacac ugaauaccaa u                                           21

<210> 295
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-5, 6-7, 8-9, 12-13, 14-15, 16-21 
<223> phosphorothioate linkage

<400> 295
auugguauuc agugugauga c                                           21

<210> 296
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 10-11, 13-20 
<223> phosphorothioate linkage

<400> 296
gguguauggc uucaacccug                                             20

<210> 297
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 13-14, 15-20 
<223> phosphorothioate linkage

<400> 297
caggguugaa gccauacacc                                             20

<210> 298
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 10-11, 13-20 
<223> phosphorothioate linkage

<400> 298
gguguauggc uucaacccug                                             20

<210> 299
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 13-14, 15-20 
<223> phosphorothioate linkage

<400> 299
caggguugaa gccauacacc                                             20

<210> 300
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15, 17, 19, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 10-11, 13-20 
<223> phosphorothioate linkage

<400> 300
gguguauggc uucaacccug                                             20

<210> 301
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 1, 19, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 13-14, 15-20 
<223> phosphorothioate linkage

<400> 301
caggguugaa gccauacacc                                             20

<210> 302
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 10-11, 13-20 
<223> phosphorothioate linkage

<400> 302
gguguauggc uucaacccug                                             20

<210> 303
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-9, 12-13, 14-20 
<223> phosphorothioate linkage

<400> 303
caggguugaa gccauacacc                                             20

<210> 304
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 5, 7, 15, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 9, 10, 11, 12, 13, 14, 16, 17, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-20 
<223> phosphorothioate linkage

<400> 304
gguguauggc uucaacccug                                             20

<210> 305
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 13-14, 15-20 
<223> phosphorothioate linkage

<400> 305
caggguugaa gccauacacc                                             20

<210> 306
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-14 
<223> phosphorothioate linkage

<400> 306
guauggcuuc aacc                                                   14

<210> 307
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 13-14, 15-20 
<223> phosphorothioate linkage

<400> 307
caggguugaa gccauacacc                                             20

<210> 308
<211> 14
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-14 
<223> phosphorothioate linkage

<400> 308
guauggcuuc aacc                                                   14

<210> 309
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 13-14, 15-20 
<223> phosphorothioate linkage

<400> 309
caggguugaa gccauacacc                                             20

<210> 310
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 5, 7, 9, 11, 12, 14, 16, 18, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 6, 8, 10, 13, 15, 17
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 9-10, 11-12, 13-19 
<223> phosphorothioate linkage

<400> 310
ggaagaaaaa ggaagcccc                                              19

<210> 311
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<221> modified_base  
<222> 2-3
<223> n = I

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 2, 3, 5, 7, 9, 10, 12, 14, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 4, 6, 8, 11, 13, 15, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 14-19 
<223> phosphorothioate linkage

<400> 311
gnngcuuccu uuuucuucc                                              19

<210> 312
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 5, 7, 9, 11, 12, 14, 16, 18, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 6, 8, 10, 13, 15, 17
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 9-10, 11-12, 13-19 
<223> phosphorothioate linkage

<400> 312
ggaagaaaaa ggaagcccc                                              19

<210> 313
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<221> modified_base  
<222> 2-3
<223> n = I

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 2, 3, 5, 7, 9, 10, 12, 14, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 4, 6, 8, 11, 13, 15, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-5, 7-8, 12-13, 14-19 
<223> phosphorothioate linkage

<400> 313
gnngcuuccu uuuucuucc                                              19

<210> 314
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 5, 7, 9, 12, 14, 16, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 6, 8, 10, 11, 13, 15, 17, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-19 
<223> phosphorothioate linkage

<400> 314
ggaagaaaaa ggaagcccc                                              19

<210> 315
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<221> modified_base  
<222> 3
<223> n = I

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 3, 5, 7, 9, 12, 14, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 4, 6, 8, 11, 13, 15, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-5, 7-8, 12-13, 14-19 
<223> phosphorothioate linkage

<400> 315
ggngcuuccu uuuucuucc                                              19

<210> 316
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 5, 7, 9, 11, 12, 14, 16, 18, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 6, 8, 10, 13, 15, 17, 19, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-12, 13-21 
<223> phosphorothioate linkage

<400> 316
ggaagaaaaa ggaagccccu u                                           21

<210> 317
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<221> modified_base  
<222> 5
<223> n = I

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 5, 6, 8, 12, 14, 16, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 4, 7, 9, 11, 13, 15, 17, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 12-13, 15-21 
<223> phosphorothioate linkage

<400> 317
aaggngcuuc cuuuuucuuc c                                           21

<210> 318
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 3, 5, 7, 9, 11, 12, 14, 16, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 4, 6, 8, 10, 13, 15, 17, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 10-11, 13-14, 15-21 
<223> phosphorothioate linkage

<400> 318
ggaagaaaaa ggaagccccu u                                           21

<210> 319
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<221> modified_base  
<222> 5
<223> n = I

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 5, 7, 9, 12, 14, 16, 18, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 6, 8, 11, 13, 15, 17, 19, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 12-13, 15-21 
<223> phosphorothioate linkage

<400> 319
aaggngcuuc cuuuuucuuc c                                           21

<210> 320
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 19, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 9-10, 11-12, 13-20 
<223> phosphorothioate linkage

<400> 320
ggugucuucc agauccugcu                                             20

<210> 321
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 15-20 
<223> phosphorothioate linkage

<400> 321
agcaggaucu ggaagacacc                                             20

<210> 322
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 19, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 10-11, 13-20 
<223> phosphorothioate linkage

<400> 322
ggugucuucc agauccugcu                                             20

<210> 323
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 13-14, 15-20 
<223> phosphorothioate linkage

<400> 323
agcaggaucu ggaagacacc                                             20

<210> 324
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 19, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 10-11, 13-20 
<223> phosphorothioate linkage

<400> 324
ggugucuucc agauccugcu                                             20

<210> 325
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 13-14, 15-20 
<223> phosphorothioate linkage

<400> 325
agcaggaucu ggaagacacc                                             20

<210> 326
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 10, 16, 18, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 8, 9, 11, 12, 13, 14, 15, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-20 
<223> phosphorothioate linkage

<400> 326
ggugucuucc agauccugcu                                             20

<210> 327
<211> 20
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 13-14, 15-20 
<223> phosphorothioate linkage

<400> 327
agcaggaucu ggaagacacc                                             20

<210> 328
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 4, 6, 8, 10, 12, 14, 16, 18, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 3, 5, 7, 9, 11, 13, 15, 17
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 10-11, 13-19 
<223> phosphorothioate linkage

<400> 328
ggugucuucc agauccugc                                              19

<210> 329
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 2, 3, 4, 6, 8, 10, 12, 14, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 5, 7, 9, 11, 13, 15, 16, 17, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 12-13, 14-19 
<223> phosphorothioate linkage

<400> 329
gcaggaucug gaagacacc                                              19

<210> 330
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 4, 6, 8, 10, 12, 14, 15, 16, 17
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 3, 5, 7, 9, 11, 13
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 10-17 
<223> phosphorothioate linkage

<400> 330
ggugucuucc agauccu                                                17

<210> 331
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 17
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 14, 15, 16
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 12-17 
<223> phosphorothioate linkage

<400> 331
aggaucugga agacacc                                                17

<210> 332
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 11-19 
<223> phosphorothioate linkage

<400> 332
ggcuggacaa gcugugcau                                              19

<210> 333
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 14-19 
<223> phosphorothioate linkage

<400> 333
augcacagcu uguccagcc                                              19

<210> 334
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 10-11, 12-19 
<223> phosphorothioate linkage

<400> 334
ggcuggacaa gcugugcau                                              19

<210> 335
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 12-13, 14-19 
<223> phosphorothioate linkage

<400> 335
augcacagcu uguccagcc                                              19

<210> 336
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 10-11, 12-19 
<223> phosphorothioate linkage

<400> 336
ggcuggacaa gcugugcau                                              19

<210> 337
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 12-13, 14-19 
<223> phosphorothioate linkage

<400> 337
augcacagcu uguccagcc                                              19

<210> 338
<211> 15
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-15 
<223> phosphorothioate linkage

<400> 338
cuggacaagc ugugc                                                  15

<210> 339
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 12-13, 14-19 
<223> phosphorothioate linkage

<400> 339
augcacagcu uguccagcc                                              19

<210> 340
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-19 
<223> phosphorothioate linkage

<400> 340
ggcuggacaa gcugugcau                                              19

<210> 341
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 12-13, 14-19 
<223> phosphorothioate linkage

<400> 341
augcacagcu uguccagcc                                              19

<210> 342
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 4, 7, 9, 13, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 3, 5, 6, 8, 10, 11, 12, 14, 15, 16, 17, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-19 
<223> phosphorothioate linkage

<400> 342
ggcuggacaa gcugugcau                                              19

<210> 343
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 16, 17, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 12-13, 14-19 
<223> phosphorothioate linkage

<400> 343
augcacagcu uguccagcc                                              19

<210> 344
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 10-11, 12-19 
<223> phosphorothioate linkage

<400> 344
ggagcuuccu gauucaaaa                                              19

<210> 345
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 7, 9, 11, 13, 15, 17, 18, 19, 20
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 14-19 
<223> phosphorothioate linkage

<400> 345
uuuugaauca ggaagcucc                                              19

<210> 346
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 9-10, 11-19 
<223> phosphorothioate linkage

<400> 346
ggagcuuccu gauucaaaa                                              19

<210> 347
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 12-13, 14-19 
<223> phosphorothioate linkage

<400> 347
uuuugaauca ggaagcucc                                              19

<210> 348
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 9-10, 11-19 
<223> phosphorothioate linkage

<400> 348
ggagcuuccu gauucaaaa                                              19

<210> 349
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 5, 7, 9, 11, 13, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 4, 6, 8, 10, 12, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-5, 7-8, 13-14, 15-19 
<223> phosphorothioate linkage

<400> 349
uuuugaauca ggaagcucc                                              19

<210> 350
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 17
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 9-10, 11-17 
<223> phosphorothioate linkage

<400> 350
ggagcuuccu gauucaa                                                17

<210> 351
<211> 17
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 3, 5, 7, 9, 11, 13, 15, 17
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 2, 4, 6, 8, 10, 12, 14, 16
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 12-17 
<223> phosphorothioate linkage

<400> 351
uugaaucagg aagcucc                                                17

<210> 352
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 6, 9, 12, 14, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 4, 5, 7, 8, 10, 11, 13, 15, 16, 17, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-19 
<223> phosphorothioate linkage

<400> 352
ggagcuuccu gauucaaaa                                              19

<210> 353
<211> 19
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 5, 8, 10, 12, 15, 17, 19
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 4, 6, 7, 9, 11, 13, 14, 16, 18
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-5, 7-8, 13-14, 15-19  
<223> phosphorothioate linkage

<400> 353
uuuugaauca ggaagcucc                                              19

<210> 354
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 11-12, 13-21 
<223> phosphorothioate linkage

<400> 354
ccgcattgcc tctgaattca a                                           21

<210> 355
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 5, 7, 9, 13, 15, 17, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 4, 6, 8, 12, 14, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 15-21 
<223> phosphorothioate linkage

<400> 355
ttgaattcag aggcaatgcg g                                           21

<210> 356
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 11-12, 13-21 
<223> phosphorothioate linkage

<400> 356
ccgcattgcc tctgaattca a                                           21

<210> 357
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 5, 7, 9, 11, 13, 15, 17, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 15-21 
<223> phosphorothioate linkage

<400> 357
ttgaattcag aggcaatgcg g                                           21

<210> 358
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 9-10, 11-12, 13-21 
<223> phosphorothioate linkage

<400> 358
ccgcattgcc tctgaattca a                                           21

<210> 359
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 5, 7, 9, 11, 13, 15, 17, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-9, 13-14, 15-21 
<223> phosphorothioate linkage

<400> 359
ttgaattcag aggcaatgcg g                                           21

<210> 360
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 9, 11, 13, 16, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 8, 10, 12, 14, 15, 17, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 9-10, 11-12, 13-21 
<223> phosphorothioate linkage

<400> 360
ccgcattgcc tctgaattca a                                           21

<210> 361
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 5, 6, 8, 10, 12, 14, 17, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 4, 7, 9, 11, 13, 15, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-9, 13-14, 15-21 
<223> phosphorothioate linkage

<400> 361
ttgaattcag aggcaatgcg g                                           21

<210> 362
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 6, 10, 16, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 4, 5, 7, 8, 9, 11, 12, 13, 14, 15, 17, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-8, 9-10, 11-12, 13-21 
<223> phosphorothioate linkage

<400> 362
ccgcattgcc tctgaattca a                                           21

<210> 363
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 5, 6, 9, 11, 13, 17, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 4, 7,8, 10, 12, 14, 15, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-9, 13-14, 15-21 
<223> phosphorothioate linkage

<400> 363
ttgaattcag aggcaatgcg g                                           21

<210> 364
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 8, 14, 16
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 6, 7, 9, 10, 11, 12, 13, 15
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-16 
<223> phosphorothioate linkage

<400> 364
gcattgcctc tgaatt                                                 16

<210> 365
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 5, 7, 9, 11, 13, 15, 17, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 4, 6, 8, 10, 12, 14, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 8-9, 13-14, 15-21 
<223> phosphorothioate linkage

<400> 365
ttgaattcag aggcaatgcg g                                           21

<210> 366
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 7, 9, 12, 15, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 6, 8, 10, 11, 13, 14, 16, 17, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 10-11, 13-21 
<223> phosphorothioate linkage

<400> 366
ccucuguugg gagucaucaa a                                           21

<210> 367
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 12, 14, 16, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-7, 15-21 
<223> phosphorothioate linkage

<400> 367
uuugaugacu cccaacagag g                                           21

<210> 368
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 7, 9, 12, 15, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 6, 8, 10, 11, 13, 14, 16, 17, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 11-12, 13-21 
<223> phosphorothioate linkage

<400> 368
ccucuguugg gagucaucaa a                                           21

<210> 369
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 12, 14, 16, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 13-14, 15-21 
<223> phosphorothioate linkage

<400> 369
uuugaugacu cccaacagag g                                           21

<210> 370
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 7, 9, 12, 15, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 6, 8, 10, 11, 13, 14, 16, 17, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 11-12, 14-21 
<223> phosphorothioate linkage

<400> 370
ccucuguugg gagucaucaa a                                           21

<210> 371
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 13-14, 15-21 
<223> phosphorothioate linkage

<400> 371
uuugaugacu cccaacagag g                                           21

<210> 372
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<221> modified_base  
<222> 10
<223> n = I

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 7, 10, 12, 15, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 6, 8, 9, 11, 13, 14, 16, 17, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 11-12, 14-21 
<223> phosphorothioate linkage

<400> 372
ccucuguugn gagucaucaa a                                           21

<210> 373
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14, 16, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 17, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 13-14, 15-21 
<223> phosphorothioate linkage

<400> 373
uuugaugacu cccaacagag g                                           21

<210> 374
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<221> modified_base  
<222> 10
<223> n = I

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 8, 10, 12, 14, 17, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 6, 7, 9, 11, 13, 15, 16, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 11-12, 14-21 
<223> phosphorothioate linkage

<400> 374
ccucuguugn gagucaucaa a                                           21

<210> 375
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 7, 9, 11, 13, 15, 16, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 6, 8, 10, 12, 14, 17, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 13-14, 15-21 
<223> phosphorothioate linkage

<400> 375
uuugaugacu cccaacagag g                                           21

<210> 376
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 8, 10, 14, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 4, 5, 6, 7, 9, 11, 12, 13, 15, 16, 17, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-21 
<223> phosphorothioate linkage

<400> 376
ccucuguugg gagucaucaa a                                           21

<210> 377
<211> 21
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 7, 9, 11, 13, 15, 16, 19, 21
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 6, 8, 10, 12, 14, 17, 18, 20
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-6, 7-8, 13-14, 15-21 
<223> phosphorothioate linkage

<400> 377
uuugaugacu cccaacagag g                                           21


<210> 378
<211> 16
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic Sequence

<220> 
<221> misc_feature   
<222> 2, 4, 6, 8, 10, 12, 14
<223> 2'-O-methyl nucleoside

<220> 
<221> misc_feature   
<222> 1, 3, 5, 7, 9, 11, 13, 15, 16
<223> 2'-fluoro nucleoside

<220> 
<221> misc_feature   
<222> 1-9, 12-16 
<223> phosphorothioate linkage

<400> 378
acauagccga augccg                                                 16
