                         SEQUENCE LISTING

<110>  Pfizer Inc
 
<120>  Cancer Treatment

<130>  PC33932A

<160>  32    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  1

Gly Phe Thr Phe Ser Ser His Gly Met His 
1               5                   10  


<210>  2
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  2

Val Ile Trp Tyr Asp Gly Arg Asn Lys Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  3
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  3

Gly Gly His Phe Gly Pro Phe Asp Tyr 
1               5                   


<210>  4
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  4

Arg Ala Ser Gln Ser Ile Ser Ser Ser Phe Leu Ala 
1               5                   10          


<210>  5
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  5

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  6
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  6

Cys Gln Gln Tyr Gly Thr Ser Pro Trp Thr 
1               5                   10  


<210>  7
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  7

Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Val Ala Ser 
1               5                   10                  15      


Gly Phe Thr Phe Ser Ser His Gly Met His Trp Val Arg Gln Ala Pro 
            20                  25                  30          


Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Arg Asn 
        35                  40                  45              


Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    50                  55                  60                  


Asn Ser Lys Asn Thr Leu Phe Leu Gln Met Asn Ser Leu Arg Ala Glu 
65                  70                  75                  80  


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Gly Gly His Phe Gly Pro Phe 
                85                  90                  95      


Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr 
            100                 105                 110         


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
        115                 120                 125             


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
    130                 135                 140                 


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
145                 150                 155                 160 


Thr Phe Pro Ala Val Leu Gln 
                165         


<210>  8
<211>  141
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
1               5                   10                  15      


Ser Cys Arg Ala Ser Gln Ser Ile Ser Ser Ser Phe Leu Ala Trp Tyr 
            20                  25                  30          


Gln Gln Arg Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser 
        35                  40                  45              


Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly 
    50                  55                  60                  


Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala 
65                  70                  75                  80  


Val Tyr Tyr Cys Gln Gln Tyr Gly Thr Ser Pro Trp Thr Phe Gly Gln 
                85                  90                  95      


Gly Thr Lys Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe 
            100                 105                 110         


Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val 
        115                 120                 125             


Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys 
    130                 135                 140     


<210>  9
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  9

Gly Phe Thr Phe Ser Ser His Gly Ile His 
1               5                   10  


<210>  10
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  10

Val Ile Trp Tyr Asp Gly Arg Asn Lys Asp Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  11
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  11

Val Ala Pro Leu Gly Pro Leu Asp Tyr 
1               5                   


<210>  12
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  12

Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala 
1               5                   10      


<210>  13
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  13

Gly Ala Ser Ser Arg Ala Thr 
1               5           


<210>  14
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  14

Cys Gln Gln Tyr Gly Arg Ser Pro Phe Thr 
1               5                   10  


<210>  15
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  15

Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe 
1               5                   10                  15      


Ser Ser His Gly Ile His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu 
            20                  25                  30          


Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Arg Asn Lys Asp Tyr Ala 
        35                  40                  45              


Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn 
    50                  55                  60                  


Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Ala Arg Val Ala Pro Leu Gly Pro Leu Asp Tyr Trp Gly 
                85                  90                  95      


Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser 
            100                 105                 110         


Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala 
        115                 120                 125             


Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val 
    130                 135                 140                 


Ser Trp Asn Ser Gly Ala Leu Thr Ser 
145                 150             


<210>  16
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  16

Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu 
1               5                   10                  15      


Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Tyr Leu Ala Trp Tyr Gln 
            20                  25                  30          


Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Gly Ala Ser Ser 
        35                  40                  45              


Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 
    50                  55                  60                  


Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 
65                  70                  75                  80  


Tyr Tyr Cys Gln Gln Tyr Gly Arg Ser Pro Phe Thr Phe Gly Pro Gly 
                85                  90                  95      


Thr Lys Val Asp Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile 
            100                 105                 110         


Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val 
        115                 120                 125             


Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys 
    130                 135                 140                 


Val Asp 
145     


<210>  17
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  17

Gly Phe Thr Phe Ser Ser Tyr Gly Met His 
1               5                   10  


<210>  18
<211>  15
<212>  PRT
<213>  Homo sapiens

<400>  18

Val Ile Trp Tyr Asp Gly Ser Asn Lys Tyr Tyr Ala Asp Ser Val 
1               5                   10                  15  


<210>  19
<211>  24
<212>  PRT
<213>  Homo sapiens

<400>  19

Thr Ala Val Tyr Tyr Cys Ala Arg Asp Pro Arg Gly Ala Thr Leu Tyr 
1               5                   10                  15      


Tyr Tyr Tyr Tyr Gly Met Asp Val 
            20                  


<210>  20
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  20

Arg Ala Ser Gln Ser Ile Asn Ser Tyr Leu Asp 
1               5                   10      


<210>  21
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  21

Ala Ala Ser Ser Leu Gln Ser 
1               5           


<210>  22
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  22

Gln Gln Tyr Tyr Ser Thr Pro Phe Thr 
1               5                   


<210>  23
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  23

Gly Val Val Gln Pro Gly Arg Ser Leu Arg Leu Ser Cys Ala Ala Ser 
1               5                   10                  15      


Gly Phe Thr Phe Ser Ser Tyr Gly Met His Trp Val Arg Gln Ala Pro 
            20                  25                  30          


Gly Lys Gly Leu Glu Trp Val Ala Val Ile Trp Tyr Asp Gly Ser Asn 
        35                  40                  45              


Lys Tyr Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp 
    50                  55                  60                  


Asn Ser Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu 
65                  70                  75                  80  


Asp Thr Ala Val Tyr Tyr Cys Ala Arg Asp Pro Arg Gly Ala Thr Leu 
                85                  90                  95      


Tyr Tyr Tyr Tyr Tyr Gly Met Asp Val Trp Gly Gln Gly Thr Thr Val 
            100                 105                 110         


Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
        115                 120                 125             


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
    130                 135                 140                 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
145                 150                 155                 160 


Ala Leu Thr Ser Gly Val His 
                165         


<210>  24
<211>  139
<212>  PRT
<213>  Homo sapiens

<400>  24

Pro Ser Ser Leu Ser Ala Ser Val Gly Asp Arg Val Thr Ile Thr Cys 
1               5                   10                  15      


Arg Ala Ser Gln Ser Ile Asn Ser Tyr Leu Asp Trp Tyr Gln Gln Lys 
            20                  25                  30          


Pro Gly Lys Ala Pro Lys Leu Leu Ile Tyr Ala Ala Ser Ser Leu Gln 
        35                  40                  45              


Ser Gly Val Pro Ser Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe 
    50                  55                  60                  


Thr Leu Thr Ile Ser Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr 
65                  70                  75                  80  


Cys Gln Gln Tyr Tyr Ser Thr Pro Phe Thr Phe Gly Pro Gly Thr Lys 
                85                  90                  95      


Val Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
            100                 105                 110         


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
        115                 120                 125             


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val 
    130                 135                 


<210>  25
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  25

Ser Tyr Thr Met His 
1               5   


<210>  26
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  26

Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  27
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  27

Thr Gly Trp Leu Gly Pro Phe Asp Tyr 
1               5                   


<210>  28
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  28

Arg Ala Ser Gln Ser Val Gly Ser Ser Tyr Leu Ala 
1               5                   10          


<210>  29
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  29

Gly Ala Phe Ser Arg Ala Thr 
1               5           


<210>  30
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  30

Gln Gln Tyr Gly Ser Ser Pro Trp Thr 
1               5                   


<210>  31
<211>  118
<212>  PRT
<213>  Homo sapiens

<400>  31

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Thr Phe Ile Ser Tyr Asp Gly Asn Asn Lys Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Ile Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Gly Trp Leu Gly Pro Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  32
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  32

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Gly Ser Ser 
            20                  25                  30          


Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 
        35                  40                  45              


Ile Tyr Gly Ala Phe Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Gly Ser Ser Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105             


