                         SEQUENCE LISTING

<110>  The Board of Trustees of the Leland Stanford Junior 
       University
       GARCIA, K. Christopher
       REDDY, Sashank  K.
       SIECZKIEWICZ, Gregory  J.
       BARNES, Thomas M.
       SCHMIDT, Michael M.
       KING, Bracken M.
       ELY, Lauren K.
 
<120>  IL-17 FAMILY CYTOKINE COMPOSITIONS AND USES

<130>  01661-5003WO

<140>  PCT/US10/52194
<141>  2010-10-11

<150>  US 61/278,779
<151>  2009-10-10

<160>  46    

<170>  PatentIn version 3.5

<210>  1
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Thr Pro Gly Lys Thr Ser Leu Val Ser Leu Leu Leu Leu Leu Ser 
1               5                   10                  15      


Leu Glu Ala Ile Val Lys Ala Gly Ile Thr Ile Pro Arg Asn Pro Gly 
            20                  25                  30          


Cys Pro Asn Ser Glu Asp Lys Asn Phe Pro Arg Thr Val Met Val Asn 
        35                  40                  45              


Leu Asn Ile His Asn Arg Asn Thr Asn Thr Asn Pro Lys Arg Ser Ser 
    50                  55                  60                  


Asp Tyr Tyr Asn Arg Ser Thr Ser Pro Trp Asn Leu His Arg Asn Glu 
65                  70                  75                  80  


Asp Pro Glu Arg Tyr Pro Ser Val Ile Trp Glu Ala Lys Cys Arg His 
                85                  90                  95      


Leu Gly Cys Ile Asn Ala Asp Gly Asn Val Asp Tyr His Met Asn Ser 
            100                 105                 110         


Val Pro Ile Gln Gln Glu Ile Leu Val Leu Arg Arg Glu Pro Pro His 
        115                 120                 125             


Cys Pro Asn Ser Phe Arg Leu Glu Lys Ile Leu Val Ser Val Gly Cys 
    130                 135                 140                 


Thr Cys Val Thr Pro Ile Val His His Val Ala 
145                 150                 155 


<210>  2
<211>  131
<212>  PRT
<213>  Homo sapiens

<400>  2

Ile Thr Ile Pro Arg Asn Pro Gly Cys Pro Asn Ser Glu Asp Lys Asn 
1               5                   10                  15      


Phe Pro Arg Thr Val Met Val Asn Leu Asn Ile His Asn Arg Asn Thr 
            20                  25                  30          


Asn Thr Asn Pro Lys Arg Ser Ser Asp Tyr Tyr Asn Arg Ser Thr Ser 
        35                  40                  45              


Pro Trp Asn Leu His Arg Asn Glu Asp Pro Glu Arg Tyr Pro Ser Val 
    50                  55                  60                  


Ile Trp Glu Ala Lys Cys Arg His Leu Gly Cys Ile Asn Ala Asp Gly 
65                  70                  75                  80  


Asn Val Asp Tyr His Met Asn Ser Val Pro Ile Gln Gln Glu Ile Leu 
                85                  90                  95      


Val Leu Arg Arg Glu Pro Pro His Cys Pro Asn Ser Phe Arg Leu Glu 
            100                 105                 110         


Lys Ile Leu Val Ser Val Gly Cys Thr Cys Val Thr Pro Ile Val His 
        115                 120                 125             


His Val Ala 
    130     


<210>  3
<211>  180
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Asp Trp Pro His Asn Leu Leu Phe Leu Leu Thr Ile Ser Ile Phe 
1               5                   10                  15      


Leu Gly Leu Gly Gln Pro Arg Ser Pro Lys Ser Lys Arg Lys Gly Gln 
            20                  25                  30          


Gly Arg Pro Gly Pro Leu Ala Pro Gly Pro His Gln Val Pro Leu Asp 
        35                  40                  45              


Leu Val Ser Arg Met Lys Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg 
    50                  55                  60                  


Asn Ile Glu Glu Met Val Ala Gln Leu Arg Asn Ser Ser Glu Leu Ala 
65                  70                  75                  80  


Gln Arg Lys Cys Glu Val Asn Leu Gln Leu Trp Met Ser Asn Lys Arg 
                85                  90                  95      


Ser Leu Ser Pro Trp Gly Tyr Ser Ile Asn His Asp Pro Ser Arg Ile 
            100                 105                 110         


Pro Val Asp Leu Pro Glu Ala Arg Cys Leu Cys Leu Gly Cys Val Asn 
        115                 120                 125             


Pro Phe Thr Met Gln Glu Asp Arg Ser Met Val Ser Val Pro Val Phe 
    130                 135                 140                 


Ser Gln Val Pro Val Arg Arg Arg Leu Cys Pro Pro Pro Pro Arg Thr 
145                 150                 155                 160 


Gly Pro Cys Arg Gln Arg Ala Val Met Glu Thr Ile Ala Val Gly Cys 
                165                 170                 175     


Thr Cys Ile Phe 
            180 


<210>  4
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  4

Arg Ser Pro Lys Ser Lys Arg Lys Gly Gln Gly Arg Pro Gly Pro Leu 
1               5                   10                  15      


Ala Pro Gly Pro His Gln Val Pro Leu Asp Leu Val Ser Arg Met Lys 
            20                  25                  30          


Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg Asn Ile Glu Glu Met Val 
        35                  40                  45              


Ala Gln Leu Arg Asn Ser Ser Glu Leu Ala Gln Arg Lys Cys Glu Val 
    50                  55                  60                  


Asn Leu Gln Leu Trp Met Ser Asn Lys Arg Ser Leu Ser Pro Trp Gly 
65                  70                  75                  80  


Tyr Ser Ile Asn His Asp Pro Ser Arg Ile Pro Val Asp Leu Pro Glu 
                85                  90                  95      


Ala Arg Cys Leu Cys Leu Gly Cys Val Asn Pro Phe Thr Met Gln Glu 
            100                 105                 110         


Asp Arg Ser Met Val Ser Val Pro Val Phe Ser Gln Val Pro Val Arg 
        115                 120                 125             


Arg Arg Leu Cys Pro Pro Pro Pro Arg Thr Gly Pro Cys Arg Gln Arg 
    130                 135                 140                 


Ala Val Met Glu Thr Ile Ala Val Gly Cys Thr Cys Ile Phe 
145                 150                 155             


<210>  5
<211>  197
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Thr Leu Leu Pro Gly Leu Leu Phe Leu Thr Trp Leu His Thr Cys 
1               5                   10                  15      


Leu Ala His His Asp Pro Ser Leu Arg Gly His Pro His Ser His Gly 
            20                  25                  30          


Thr Pro His Cys Tyr Ser Ala Glu Glu Leu Pro Leu Gly Gln Ala Pro 
        35                  40                  45              


Pro His Leu Leu Ala Arg Gly Ala Lys Trp Gly Gln Ala Leu Pro Val 
    50                  55                  60                  


Ala Leu Val Ser Ser Leu Glu Ala Ala Ser His Arg Gly Arg His Glu 
65                  70                  75                  80  


Arg Pro Ser Ala Thr Thr Gln Cys Pro Val Leu Arg Pro Glu Glu Val 
                85                  90                  95      


Leu Glu Ala Asp Thr His Gln Arg Ser Ile Ser Pro Trp Arg Tyr Arg 
            100                 105                 110         


Val Asp Thr Asp Glu Asp Arg Tyr Pro Gln Lys Leu Ala Phe Ala Glu 
        115                 120                 125             


Cys Leu Cys Arg Gly Cys Ile Asp Ala Arg Thr Gly Arg Glu Thr Ala 
    130                 135                 140                 


Ala Leu Asn Ser Val Arg Leu Leu Gln Ser Leu Leu Val Leu Arg Arg 
145                 150                 155                 160 


Arg Pro Cys Ser Arg Asp Gly Ser Gly Leu Pro Thr Pro Gly Ala Phe 
                165                 170                 175     


Ala Phe His Thr Glu Phe Ile His Val Pro Val Gly Cys Thr Cys Val 
            180                 185                 190         


Leu Pro Arg Ser Val 
        195         


<210>  6
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  6

His His Asp Pro Ser Leu Arg Gly His Pro His Ser His Gly Thr Pro 
1               5                   10                  15      


His Cys Tyr Ser Ala Glu Glu Leu Pro Leu Gly Gln Ala Pro Pro His 
            20                  25                  30          


Leu Leu Ala Arg Gly Ala Lys Trp Gly Gln Ala Leu Pro Val Ala Leu 
        35                  40                  45              


Val Ser Ser Leu Glu Ala Ala Ser His Arg Gly Arg His Glu Arg Pro 
    50                  55                  60                  


Ser Ala Thr Thr Gln Cys Pro Val Leu Arg Pro Glu Glu Val Leu Glu 
65                  70                  75                  80  


Ala Asp Thr His Gln Arg Ser Ile Ser Pro Trp Arg Tyr Arg Val Asp 
                85                  90                  95      


Thr Asp Glu Asp Arg Tyr Pro Gln Lys Leu Ala Phe Ala Glu Cys Leu 
            100                 105                 110         


Cys Arg Gly Cys Ile Asp Ala Arg Thr Gly Arg Glu Thr Ala Ala Leu 
        115                 120                 125             


Asn Ser Val Arg Leu Leu Gln Ser Leu Leu Val Leu Arg Arg Arg Pro 
    130                 135                 140                 


Cys Ser Arg Asp Gly Ser Gly Leu Pro Thr Pro Gly Ala Phe Ala Phe 
145                 150                 155                 160 


His Thr Glu Phe Ile His Val Pro Val Gly Cys Thr Cys Val Leu Pro 
                165                 170                 175     


Arg Ser Val 
            


<210>  7
<211>  202
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Leu Val Ala Gly Phe Leu Leu Ala Leu Pro Pro Ser Trp Ala Ala 
1               5                   10                  15      


Gly Ala Pro Arg Ala Gly Arg Arg Pro Ala Arg Pro Arg Gly Cys Ala 
            20                  25                  30          


Asp Arg Pro Glu Glu Leu Leu Glu Gln Leu Tyr Gly Arg Leu Ala Ala 
        35                  40                  45              


Gly Val Leu Ser Ala Phe His His Thr Leu Gln Leu Gly Pro Arg Glu 
    50                  55                  60                  


Gln Ala Arg Asn Ala Ser Cys Pro Ala Gly Gly Arg Pro Ala Asp Arg 
65                  70                  75                  80  


Arg Phe Arg Pro Pro Thr Asn Leu Arg Ser Val Ser Pro Trp Ala Tyr 
                85                  90                  95      


Arg Ile Ser Tyr Asp Pro Ala Arg Tyr Pro Arg Tyr Leu Pro Glu Ala 
            100                 105                 110         


Tyr Cys Leu Cys Arg Gly Cys Leu Thr Gly Leu Phe Gly Glu Glu Asp 
        115                 120                 125             


Val Arg Phe Arg Ser Ala Pro Val Tyr Met Pro Thr Val Val Leu Arg 
    130                 135                 140                 


Arg Thr Pro Ala Cys Ala Gly Gly Arg Ser Val Tyr Thr Glu Ala Tyr 
145                 150                 155                 160 


Val Thr Ile Pro Val Gly Cys Thr Cys Val Pro Glu Pro Glu Lys Asp 
                165                 170                 175     


Ala Asp Ser Ile Asn Ser Ser Ile Asp Lys Gln Gly Ala Lys Leu Leu 
            180                 185                 190         


Leu Gly Pro Asn Asp Ala Pro Ala Gly Pro 
        195                 200         


<210>  8
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  8

Ala Gly Ala Pro Arg Ala Gly Arg Arg Pro Ala Arg Pro Arg Gly Cys 
1               5                   10                  15      


Ala Asp Arg Pro Glu Glu Leu Leu Glu Gln Leu Tyr Gly Arg Leu Ala 
            20                  25                  30          


Ala Gly Val Leu Ser Ala Phe His His Thr Leu Gln Leu Gly Pro Arg 
        35                  40                  45              


Glu Gln Ala Arg Asn Ala Ser Cys Pro Ala Gly Gly Arg Pro Ala Asp 
    50                  55                  60                  


Arg Arg Phe Arg Pro Pro Thr Asn Leu Arg Ser Val Ser Pro Trp Ala 
65                  70                  75                  80  


Tyr Arg Ile Ser Tyr Asp Pro Ala Arg Tyr Pro Arg Tyr Leu Pro Glu 
                85                  90                  95      


Ala Tyr Cys Leu Cys Arg Gly Cys Leu Thr Gly Leu Phe Gly Glu Glu 
            100                 105                 110         


Asp Val Arg Phe Arg Ser Ala Pro Val Tyr Met Pro Thr Val Val Leu 
        115                 120                 125             


Arg Arg Thr Pro Ala Cys Ala Gly Gly Arg Ser Val Tyr Thr Glu Ala 
    130                 135                 140                 


Tyr Val Thr Ile Pro Val Gly Cys Thr Cys Val Pro Glu Pro Glu Lys 
145                 150                 155                 160 


Asp Ala Asp Ser Ile Asn Ser Ser Ile Asp Lys Gln Gly Ala Lys Leu 
                165                 170                 175     


Leu Leu Gly Pro Asn Asp Ala Pro Ala Gly Pro 
            180                 185         


<210>  9
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Arg Glu Arg Pro Arg Leu Gly Glu Asp Ser Ser Leu Ile Ser Leu 
1               5                   10                  15      


Phe Leu Gln Val Val Ala Phe Leu Ala Met Val Met Gly Thr His Thr 
            20                  25                  30          


Tyr Ser His Trp Pro Ser Cys Cys Pro Ser Lys Gly Gln Asp Thr Ser 
        35                  40                  45              


Glu Glu Leu Leu Arg Trp Ser Thr Val Pro Val Pro Pro Leu Glu Pro 
    50                  55                  60                  


Ala Arg Pro Asn Arg His Pro Glu Ser Cys Arg Ala Ser Glu Asp Gly 
65                  70                  75                  80  


Pro Leu Asn Ser Arg Ala Ile Ser Pro Trp Arg Tyr Glu Leu Asp Arg 
                85                  90                  95      


Asp Leu Asn Arg Leu Pro Gln Asp Leu Tyr His Ala Arg Cys Leu Cys 
            100                 105                 110         


Pro His Cys Val Ser Leu Gln Thr Gly Ser His Met Asp Pro Arg Gly 
        115                 120                 125             


Asn Ser Glu Leu Leu Tyr His Asn Gln Thr Val Phe Tyr Arg Arg Pro 
    130                 135                 140                 


Cys His Gly Glu Lys Gly Thr His Lys Gly Tyr Cys Leu Glu Arg Arg 
145                 150                 155                 160 


Leu Tyr Arg Val Ser Leu Ala Cys Val Cys Val Arg Pro Arg Val Met 
                165                 170                 175     


Gly 
    


<210>  10
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  10

Thr His Thr Tyr Ser His Trp Pro Ser Cys Cys Pro Ser Lys Gly Gln 
1               5                   10                  15      


Asp Thr Ser Glu Glu Leu Leu Arg Trp Ser Thr Val Pro Val Pro Pro 
            20                  25                  30          


Leu Glu Pro Ala Arg Pro Asn Arg His Pro Glu Ser Cys Arg Ala Ser 
        35                  40                  45              


Glu Asp Gly Pro Leu Asn Ser Arg Ala Ile Ser Pro Trp Arg Tyr Glu 
    50                  55                  60                  


Leu Asp Arg Asp Leu Asn Arg Leu Pro Gln Asp Leu Tyr His Ala Arg 
65                  70                  75                  80  


Cys Leu Cys Pro His Cys Val Ser Leu Gln Thr Gly Ser His Met Asp 
                85                  90                  95      


Pro Arg Gly Asn Ser Glu Leu Leu Tyr His Asn Gln Thr Val Phe Tyr 
            100                 105                 110         


Arg Arg Pro Cys His Gly Glu Lys Gly Thr His Lys Gly Tyr Cys Leu 
        115                 120                 125             


Glu Arg Arg Leu Tyr Arg Val Ser Leu Ala Cys Val Cys Val Arg Pro 
    130                 135                 140                 


Arg Val Met Gly 
145             


<210>  11
<211>  163
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Thr Val Lys Thr Leu His Gly Pro Ala Met Val Lys Tyr Leu Leu 
1               5                   10                  15      


Leu Ser Ile Leu Gly Leu Ala Phe Leu Ser Glu Ala Ala Ala Arg Lys 
            20                  25                  30          


Ile Pro Lys Val Gly His Thr Phe Phe Gln Lys Pro Glu Ser Cys Pro 
        35                  40                  45              


Pro Val Pro Gly Gly Ser Met Lys Leu Asp Ile Gly Ile Ile Asn Glu 
    50                  55                  60                  


Asn Gln Arg Val Ser Met Ser Arg Asn Ile Glu Ser Arg Ser Thr Ser 
65                  70                  75                  80  


Pro Trp Asn Tyr Thr Val Thr Trp Asp Pro Asn Arg Tyr Pro Ser Glu 
                85                  90                  95      


Val Val Gln Ala Gln Cys Arg Asn Leu Gly Cys Ile Asn Ala Gln Gly 
            100                 105                 110         


Lys Glu Asp Ile Ser Met Asn Ser Val Pro Ile Gln Gln Glu Thr Leu 
        115                 120                 125             


Val Val Arg Arg Lys His Gln Gly Cys Ser Val Ser Phe Gln Leu Glu 
    130                 135                 140                 


Lys Val Leu Val Thr Val Gly Cys Thr Cys Val Thr Pro Val Ile His 
145                 150                 155                 160 


His Val Gln 
            


<210>  12
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  12

Arg Lys Ile Pro Lys Val Gly His Thr Phe Phe Gln Lys Pro Glu Ser 
1               5                   10                  15      


Cys Pro Pro Val Pro Gly Gly Ser Met Lys Leu Asp Ile Gly Ile Ile 
            20                  25                  30          


Asn Glu Asn Gln Arg Val Ser Met Ser Arg Asn Ile Glu Ser Arg Ser 
        35                  40                  45              


Thr Ser Pro Trp Asn Tyr Thr Val Thr Trp Asp Pro Asn Arg Tyr Pro 
    50                  55                  60                  


Ser Glu Val Val Gln Ala Gln Cys Arg Asn Leu Gly Cys Ile Asn Ala 
65                  70                  75                  80  


Gln Gly Lys Glu Asp Ile Ser Met Asn Ser Val Pro Ile Gln Gln Glu 
                85                  90                  95      


Thr Leu Val Val Arg Arg Lys His Gln Gly Cys Ser Val Ser Phe Gln 
            100                 105                 110         


Leu Glu Lys Val Leu Val Thr Val Gly Cys Thr Cys Val Thr Pro Val 
        115                 120                 125             


Ile His His Val Gln 
    130             


<210>  13
<211>  866
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Gly Ala Ala Arg Ser Pro Pro Ser Ala Val Pro Gly Pro Leu Leu 
1               5                   10                  15      


Gly Leu Leu Leu Leu Leu Leu Gly Val Leu Ala Pro Gly Gly Ala Ser 
            20                  25                  30          


Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly Leu 
        35                  40                  45              


Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile His 
    50                  55                  60                  


Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln Leu 
65                  70                  75                  80  


His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His Ile 
                85                  90                  95      


Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly Ala 
            100                 105                 110         


Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val Arg 
        115                 120                 125             


Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg Phe 
    130                 135                 140                 


Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val Thr 
145                 150                 155                 160 


Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His Gln 
                165                 170                 175     


Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys Val 
            180                 185                 190         


Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile Thr 
        195                 200                 205             


Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu Trp 
    210                 215                 220                 


Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His Met 
225                 230                 235                 240 


Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro Arg 
                245                 250                 255     


Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg Asn 
            260                 265                 270         


Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe Ser 
        275                 280                 285             


Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys Pro 
    290                 295                 300                 


Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr Met Pro Leu Trp 
305                 310                 315                 320 


Val Tyr Trp Phe Ile Thr Gly Ile Ser Ile Leu Leu Val Gly Ser Val 
                325                 330                 335     


Ile Leu Leu Ile Val Cys Met Thr Trp Arg Leu Ala Gly Pro Gly Ser 
            340                 345                 350         


Glu Lys Tyr Ser Asp Asp Thr Lys Tyr Thr Asp Gly Leu Pro Ala Ala 
        355                 360                 365             


Asp Leu Ile Pro Pro Pro Leu Lys Pro Arg Lys Val Trp Ile Ile Tyr 
    370                 375                 380                 


Ser Ala Asp His Pro Leu Tyr Val Asp Val Val Leu Lys Phe Ala Gln 
385                 390                 395                 400 


Phe Leu Leu Thr Ala Cys Gly Thr Glu Val Ala Leu Asp Leu Leu Glu 
                405                 410                 415     


Glu Gln Ala Ile Ser Glu Ala Gly Val Met Thr Trp Val Gly Arg Gln 
            420                 425                 430         


Lys Gln Glu Met Val Glu Ser Asn Ser Lys Ile Ile Val Leu Cys Ser 
        435                 440                 445             


Arg Gly Thr Arg Ala Lys Trp Gln Ala Leu Leu Gly Arg Gly Ala Pro 
    450                 455                 460                 


Val Arg Leu Arg Cys Asp His Gly Lys Pro Val Gly Asp Leu Phe Thr 
465                 470                 475                 480 


Ala Ala Met Asn Met Ile Leu Pro Asp Phe Lys Arg Pro Ala Cys Phe 
                485                 490                 495     


Gly Thr Tyr Val Val Cys Tyr Phe Ser Glu Val Ser Cys Asp Gly Asp 
            500                 505                 510         


Val Pro Asp Leu Phe Gly Ala Ala Pro Arg Tyr Pro Leu Met Asp Arg 
        515                 520                 525             


Phe Glu Glu Val Tyr Phe Arg Ile Gln Asp Leu Glu Met Phe Gln Pro 
    530                 535                 540                 


Gly Arg Met His Arg Val Gly Glu Leu Ser Gly Asp Asn Tyr Leu Arg 
545                 550                 555                 560 


Ser Pro Gly Gly Arg Gln Leu Arg Ala Ala Leu Asp Arg Phe Arg Asp 
                565                 570                 575     


Trp Gln Val Arg Cys Pro Asp Trp Phe Glu Cys Glu Asn Leu Tyr Ser 
            580                 585                 590         


Ala Asp Asp Gln Asp Ala Pro Ser Leu Asp Glu Glu Val Phe Glu Glu 
        595                 600                 605             


Pro Leu Leu Pro Pro Gly Thr Gly Ile Val Lys Arg Ala Pro Leu Val 
    610                 615                 620                 


Arg Glu Pro Gly Ser Gln Ala Cys Leu Ala Ile Asp Pro Leu Val Gly 
625                 630                 635                 640 


Glu Glu Gly Gly Ala Ala Val Ala Lys Leu Glu Pro His Leu Gln Pro 
                645                 650                 655     


Arg Gly Gln Pro Ala Pro Gln Pro Leu His Thr Leu Val Leu Ala Ala 
            660                 665                 670         


Glu Glu Gly Ala Leu Val Ala Ala Val Glu Pro Gly Pro Leu Ala Asp 
        675                 680                 685             


Gly Ala Ala Val Arg Leu Ala Leu Ala Gly Glu Gly Glu Ala Cys Pro 
    690                 695                 700                 


Leu Leu Gly Ser Pro Gly Ala Gly Arg Asn Ser Val Leu Phe Leu Pro 
705                 710                 715                 720 


Val Asp Pro Glu Asp Ser Pro Leu Gly Ser Ser Thr Pro Met Ala Ser 
                725                 730                 735     


Pro Asp Leu Leu Pro Glu Asp Val Arg Glu His Leu Glu Gly Leu Met 
            740                 745                 750         


Leu Ser Leu Phe Glu Gln Ser Leu Ser Cys Gln Ala Gln Gly Gly Cys 
        755                 760                 765             


Ser Arg Pro Ala Met Val Leu Thr Asp Pro His Thr Pro Tyr Glu Glu 
    770                 775                 780                 


Glu Gln Arg Gln Ser Val Gln Ser Asp Gln Gly Tyr Ile Ser Arg Ser 
785                 790                 795                 800 


Ser Pro Gln Pro Pro Glu Gly Leu Thr Glu Met Glu Glu Glu Glu Glu 
                805                 810                 815     


Glu Glu Gln Asp Pro Gly Lys Pro Ala Leu Pro Leu Ser Pro Glu Asp 
            820                 825                 830         


Leu Glu Ser Leu Arg Ser Leu Gln Arg Gln Leu Leu Phe Arg Gln Leu 
        835                 840                 845             


Gln Lys Asn Ser Gly Trp Asp Thr Met Gly Ser Glu Ser Glu Gly Pro 
    850                 855                 860                 


Ser Ala 
865     


<210>  14
<211>  835
<212>  PRT
<213>  Homo sapiens

<400>  14

Ser Leu Arg Leu Leu Asp His Arg Ala Leu Val Cys Ser Gln Pro Gly 
1               5                   10                  15      


Leu Asn Cys Thr Val Lys Asn Ser Thr Cys Leu Asp Asp Ser Trp Ile 
            20                  25                  30          


His Pro Arg Asn Leu Thr Pro Ser Ser Pro Lys Asp Leu Gln Ile Gln 
        35                  40                  45              


Leu His Phe Ala His Thr Gln Gln Gly Asp Leu Phe Pro Val Ala His 
    50                  55                  60                  


Ile Glu Trp Thr Leu Gln Thr Asp Ala Ser Ile Leu Tyr Leu Glu Gly 
65                  70                  75                  80  


Ala Glu Leu Ser Val Leu Gln Leu Asn Thr Asn Glu Arg Leu Cys Val 
                85                  90                  95      


Arg Phe Glu Phe Leu Ser Lys Leu Arg His His His Arg Arg Trp Arg 
            100                 105                 110         


Phe Thr Phe Ser His Phe Val Val Asp Pro Asp Gln Glu Tyr Glu Val 
        115                 120                 125             


Thr Val His His Leu Pro Lys Pro Ile Pro Asp Gly Asp Pro Asn His 
    130                 135                 140                 


Gln Ser Lys Asn Phe Leu Val Pro Asp Cys Glu His Ala Arg Met Lys 
145                 150                 155                 160 


Val Thr Thr Pro Cys Met Ser Ser Gly Ser Leu Trp Asp Pro Asn Ile 
                165                 170                 175     


Thr Val Glu Thr Leu Glu Ala His Gln Leu Arg Val Ser Phe Thr Leu 
            180                 185                 190         


Trp Asn Glu Ser Thr His Tyr Gln Ile Leu Leu Thr Ser Phe Pro His 
        195                 200                 205             


Met Glu Asn His Ser Cys Phe Glu His Met His His Ile Pro Ala Pro 
    210                 215                 220                 


Arg Pro Glu Glu Phe His Gln Arg Ser Asn Val Thr Leu Thr Leu Arg 
225                 230                 235                 240 


Asn Leu Lys Gly Cys Cys Arg His Gln Val Gln Ile Gln Pro Phe Phe 
                245                 250                 255     


Ser Ser Cys Leu Asn Asp Cys Leu Arg His Ser Ala Thr Val Ser Cys 
            260                 265                 270         


Pro Glu Met Pro Asp Thr Pro Glu Pro Ile Pro Asp Tyr Met Pro Leu 
        275                 280                 285             


Trp Val Tyr Trp Phe Ile Thr Gly Ile Ser Ile Leu Leu Val Gly Ser 
    290                 295                 300                 


Val Ile Leu Leu Ile Val Cys Met Thr Trp Arg Leu Ala Gly Pro Gly 
305                 310                 315                 320 


Ser Glu Lys Tyr Ser Asp Asp Thr Lys Tyr Thr Asp Gly Leu Pro Ala 
                325                 330                 335     


Ala Asp Leu Ile Pro Pro Pro Leu Lys Pro Arg Lys Val Trp Ile Ile 
            340                 345                 350         


Tyr Ser Ala Asp His Pro Leu Tyr Val Asp Val Val Leu Lys Phe Ala 
        355                 360                 365             


Gln Phe Leu Leu Thr Ala Cys Gly Thr Glu Val Ala Leu Asp Leu Leu 
    370                 375                 380                 


Glu Glu Gln Ala Ile Ser Glu Ala Gly Val Met Thr Trp Val Gly Arg 
385                 390                 395                 400 


Gln Lys Gln Glu Met Val Glu Ser Asn Ser Lys Ile Ile Val Leu Cys 
                405                 410                 415     


Ser Arg Gly Thr Arg Ala Lys Trp Gln Ala Leu Leu Gly Arg Gly Ala 
            420                 425                 430         


Pro Val Arg Leu Arg Cys Asp His Gly Lys Pro Val Gly Asp Leu Phe 
        435                 440                 445             


Thr Ala Ala Met Asn Met Ile Leu Pro Asp Phe Lys Arg Pro Ala Cys 
    450                 455                 460                 


Phe Gly Thr Tyr Val Val Cys Tyr Phe Ser Glu Val Ser Cys Asp Gly 
465                 470                 475                 480 


Asp Val Pro Asp Leu Phe Gly Ala Ala Pro Arg Tyr Pro Leu Met Asp 
                485                 490                 495     


Arg Phe Glu Glu Val Tyr Phe Arg Ile Gln Asp Leu Glu Met Phe Gln 
            500                 505                 510         


Pro Gly Arg Met His Arg Val Gly Glu Leu Ser Gly Asp Asn Tyr Leu 
        515                 520                 525             


Arg Ser Pro Gly Gly Arg Gln Leu Arg Ala Ala Leu Asp Arg Phe Arg 
    530                 535                 540                 


Asp Trp Gln Val Arg Cys Pro Asp Trp Phe Glu Cys Glu Asn Leu Tyr 
545                 550                 555                 560 


Ser Ala Asp Asp Gln Asp Ala Pro Ser Leu Asp Glu Glu Val Phe Glu 
                565                 570                 575     


Glu Pro Leu Leu Pro Pro Gly Thr Gly Ile Val Lys Arg Ala Pro Leu 
            580                 585                 590         


Val Arg Glu Pro Gly Ser Gln Ala Cys Leu Ala Ile Asp Pro Leu Val 
        595                 600                 605             


Gly Glu Glu Gly Gly Ala Ala Val Ala Lys Leu Glu Pro His Leu Gln 
    610                 615                 620                 


Pro Arg Gly Gln Pro Ala Pro Gln Pro Leu His Thr Leu Val Leu Ala 
625                 630                 635                 640 


Ala Glu Glu Gly Ala Leu Val Ala Ala Val Glu Pro Gly Pro Leu Ala 
                645                 650                 655     


Asp Gly Ala Ala Val Arg Leu Ala Leu Ala Gly Glu Gly Glu Ala Cys 
            660                 665                 670         


Pro Leu Leu Gly Ser Pro Gly Ala Gly Arg Asn Ser Val Leu Phe Leu 
        675                 680                 685             


Pro Val Asp Pro Glu Asp Ser Pro Leu Gly Ser Ser Thr Pro Met Ala 
    690                 695                 700                 


Ser Pro Asp Leu Leu Pro Glu Asp Val Arg Glu His Leu Glu Gly Leu 
705                 710                 715                 720 


Met Leu Ser Leu Phe Glu Gln Ser Leu Ser Cys Gln Ala Gln Gly Gly 
                725                 730                 735     


Cys Ser Arg Pro Ala Met Val Leu Thr Asp Pro His Thr Pro Tyr Glu 
            740                 745                 750         


Glu Glu Gln Arg Gln Ser Val Gln Ser Asp Gln Gly Tyr Ile Ser Arg 
        755                 760                 765             


Ser Ser Pro Gln Pro Pro Glu Gly Leu Thr Glu Met Glu Glu Glu Glu 
    770                 775                 780                 


Glu Glu Glu Gln Asp Pro Gly Lys Pro Ala Leu Pro Leu Ser Pro Glu 
785                 790                 795                 800 


Asp Leu Glu Ser Leu Arg Ser Leu Gln Arg Gln Leu Leu Phe Arg Gln 
                805                 810                 815     


Leu Gln Lys Asn Ser Gly Trp Asp Thr Met Gly Ser Glu Ser Glu Gly 
            820                 825                 830         


Pro Ser Ala 
        835 


<210>  15
<211>  502
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Leu Val Leu Leu Ser Leu Ala Ala Leu Cys Arg Ser Ala Val 
1               5                   10                  15      


Pro Arg Glu Pro Thr Val Gln Cys Gly Ser Glu Thr Gly Pro Ser Pro 
            20                  25                  30          


Glu Trp Met Leu Gln His Asp Leu Ile Pro Gly Asp Leu Arg Asp Leu 
        35                  40                  45              


Arg Val Glu Pro Val Thr Thr Ser Val Ala Thr Gly Asp Tyr Ser Ile 
    50                  55                  60                  


Leu Met Asn Val Ser Trp Val Leu Arg Ala Asp Ala Ser Ile Arg Leu 
65                  70                  75                  80  


Leu Lys Ala Thr Lys Ile Cys Val Thr Gly Lys Ser Asn Phe Gln Ser 
                85                  90                  95      


Tyr Ser Cys Val Arg Cys Asn Tyr Thr Glu Ala Phe Gln Thr Gln Thr 
            100                 105                 110         


Arg Pro Ser Gly Gly Lys Trp Thr Phe Ser Tyr Ile Gly Phe Pro Val 
        115                 120                 125             


Glu Leu Asn Thr Val Tyr Phe Ile Gly Ala His Asn Ile Pro Asn Ala 
    130                 135                 140                 


Asn Met Asn Glu Asp Gly Pro Ser Met Ser Val Asn Phe Thr Ser Pro 
145                 150                 155                 160 


Gly Cys Leu Asp His Ile Met Lys Tyr Lys Lys Lys Cys Val Lys Ala 
                165                 170                 175     


Gly Ser Leu Trp Asp Pro Asn Ile Thr Ala Cys Lys Lys Asn Glu Glu 
            180                 185                 190         


Thr Val Glu Val Asn Phe Thr Thr Thr Pro Leu Gly Asn Arg Tyr Met 
        195                 200                 205             


Ala Leu Ile Gln His Ser Thr Ile Ile Gly Phe Ser Gln Val Phe Glu 
    210                 215                 220                 


Pro His Gln Lys Lys Gln Thr Arg Ala Ser Val Val Ile Pro Val Thr 
225                 230                 235                 240 


Gly Asp Ser Glu Gly Ala Thr Val Gln Leu Thr Pro Tyr Phe Pro Thr 
                245                 250                 255     


Cys Gly Ser Asp Cys Ile Arg His Lys Gly Thr Val Val Leu Cys Pro 
            260                 265                 270         


Gln Thr Gly Val Pro Phe Pro Leu Asp Asn Asn Lys Ser Lys Pro Gly 
        275                 280                 285             


Gly Trp Leu Pro Leu Leu Leu Leu Ser Leu Leu Val Ala Thr Trp Val 
    290                 295                 300                 


Leu Val Ala Gly Ile Tyr Leu Met Trp Arg His Glu Arg Ile Lys Lys 
305                 310                 315                 320 


Thr Ser Phe Ser Thr Thr Thr Leu Leu Pro Pro Ile Lys Val Leu Val 
                325                 330                 335     


Val Tyr Pro Ser Glu Ile Cys Phe His His Thr Ile Cys Tyr Phe Thr 
            340                 345                 350         


Glu Phe Leu Gln Asn His Cys Arg Ser Glu Val Ile Leu Glu Lys Trp 
        355                 360                 365             


Gln Lys Lys Lys Ile Ala Glu Met Gly Pro Val Gln Trp Leu Ala Thr 
    370                 375                 380                 


Gln Lys Lys Ala Ala Asp Lys Val Val Phe Leu Leu Ser Asn Asp Val 
385                 390                 395                 400 


Asn Ser Val Cys Asp Gly Thr Cys Gly Lys Ser Glu Gly Ser Pro Ser 
                405                 410                 415     


Glu Asn Ser Gln Asp Leu Phe Pro Leu Ala Phe Asn Leu Phe Cys Ser 
            420                 425                 430         


Asp Leu Arg Ser Gln Ile His Leu His Lys Tyr Val Val Val Tyr Phe 
        435                 440                 445             


Arg Glu Ile Asp Thr Lys Asp Asp Tyr Asn Ala Leu Ser Val Cys Pro 
    450                 455                 460                 


Lys Tyr His Leu Met Lys Asp Ala Thr Ala Phe Cys Ala Glu Leu Leu 
465                 470                 475                 480 


His Val Lys Gln Gln Val Ser Ala Gly Lys Arg Ser Gln Ala Cys His 
                485                 490                 495     


Asp Gly Cys Cys Ser Leu 
            500         


<210>  16
<211>  791
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Pro Val Pro Trp Phe Leu Leu Ser Leu Ala Leu Gly Arg Ser Pro 
1               5                   10                  15      


Val Val Leu Ser Leu Glu Arg Leu Val Gly Pro Gln Asp Ala Thr His 
            20                  25                  30          


Cys Ser Pro Val Ser Leu Glu Pro Trp Gly Asp Glu Glu Arg Leu Arg 
        35                  40                  45              


Val Gln Phe Leu Ala Gln Gln Ser Leu Ser Leu Ala Pro Val Thr Ala 
    50                  55                  60                  


Ala Thr Ala Arg Thr Ala Leu Ser Gly Leu Ser Gly Ala Asp Gly Arg 
65                  70                  75                  80  


Arg Glu Glu Arg Gly Arg Gly Lys Ser Trp Val Cys Leu Ser Leu Gly 
                85                  90                  95      


Gly Ser Gly Asn Thr Glu Pro Gln Lys Lys Gly Leu Ser Cys Arg Leu 
            100                 105                 110         


Trp Asp Ser Asp Ile Leu Cys Leu Pro Gly Asp Ile Val Pro Ala Pro 
        115                 120                 125             


Gly Pro Val Leu Ala Pro Thr His Leu Gln Thr Glu Leu Val Leu Arg 
    130                 135                 140                 


Cys Gln Lys Glu Thr Asp Cys Asp Leu Cys Leu Arg Val Ala Val His 
145                 150                 155                 160 


Leu Ala Val His Gly His Trp Glu Glu Pro Glu Asp Glu Glu Lys Phe 
                165                 170                 175     


Gly Gly Ala Ala Asp Ser Gly Val Glu Glu Pro Arg Asn Ala Ser Leu 
            180                 185                 190         


Gln Ala Gln Val Val Leu Ser Phe Gln Ala Tyr Pro Thr Ala Arg Cys 
        195                 200                 205             


Val Leu Leu Glu Val Gln Val Pro Ala Ala Leu Val Gln Phe Gly Gln 
    210                 215                 220                 


Ser Val Gly Ser Val Val Tyr Asp Cys Phe Glu Ala Ala Leu Gly Ser 
225                 230                 235                 240 


Glu Val Arg Ile Trp Ser Tyr Thr Gln Pro Arg Tyr Glu Lys Glu Leu 
                245                 250                 255     


Asn His Thr Gln Gln Leu Pro Asp Cys Arg Gly Leu Glu Val Trp Asn 
            260                 265                 270         


Ser Ile Pro Ser Cys Trp Ala Leu Pro Trp Leu Asn Val Ser Ala Asp 
        275                 280                 285             


Gly Asp Asn Val His Leu Val Leu Asn Val Ser Glu Glu Gln His Phe 
    290                 295                 300                 


Gly Leu Ser Leu Tyr Trp Asn Gln Val Gln Gly Pro Pro Lys Pro Arg 
305                 310                 315                 320 


Trp His Lys Asn Leu Thr Gly Pro Gln Ile Ile Thr Leu Asn His Thr 
                325                 330                 335     


Asp Leu Val Pro Cys Leu Cys Ile Gln Val Trp Pro Leu Glu Pro Asp 
            340                 345                 350         


Ser Val Arg Thr Asn Ile Cys Pro Phe Arg Glu Asp Pro Arg Ala His 
        355                 360                 365             


Gln Asn Leu Trp Gln Ala Ala Arg Leu Gln Leu Leu Thr Leu Gln Ser 
    370                 375                 380                 


Trp Leu Leu Asp Ala Pro Cys Ser Leu Pro Ala Glu Ala Ala Leu Cys 
385                 390                 395                 400 


Trp Arg Ala Pro Gly Gly Asp Pro Cys Gln Pro Leu Val Pro Pro Leu 
                405                 410                 415     


Ser Trp Glu Asn Val Thr Val Asp Lys Val Leu Glu Phe Pro Leu Leu 
            420                 425                 430         


Lys Gly His Pro Asn Leu Cys Val Gln Val Asn Ser Ser Glu Lys Leu 
        435                 440                 445             


Gln Leu Gln Glu Cys Leu Trp Ala Asp Ser Leu Gly Pro Leu Lys Asp 
    450                 455                 460                 


Asp Val Leu Leu Leu Glu Thr Arg Gly Pro Gln Asp Asn Arg Ser Leu 
465                 470                 475                 480 


Cys Ala Leu Glu Pro Ser Gly Cys Thr Ser Leu Pro Ser Lys Ala Ser 
                485                 490                 495     


Thr Arg Ala Ala Arg Leu Gly Glu Tyr Leu Leu Gln Asp Leu Gln Ser 
            500                 505                 510         


Gly Gln Cys Leu Gln Leu Trp Asp Asp Asp Leu Gly Ala Leu Trp Ala 
        515                 520                 525             


Cys Pro Met Asp Lys Tyr Ile His Lys Arg Trp Ala Leu Val Trp Leu 
    530                 535                 540                 


Ala Cys Leu Leu Phe Ala Ala Ala Leu Ser Leu Ile Leu Leu Leu Lys 
545                 550                 555                 560 


Lys Asp His Ala Lys Gly Trp Leu Arg Leu Leu Lys Gln Asp Val Arg 
                565                 570                 575     


Ser Gly Ala Ala Ala Arg Gly Arg Ala Ala Leu Leu Leu Tyr Ser Ala 
            580                 585                 590         


Asp Asp Ser Gly Phe Glu Arg Leu Val Gly Ala Leu Ala Ser Ala Leu 
        595                 600                 605             


Cys Gln Leu Pro Leu Arg Val Ala Val Asp Leu Trp Ser Arg Arg Glu 
    610                 615                 620                 


Leu Ser Ala Gln Gly Pro Val Ala Trp Phe His Ala Gln Arg Arg Gln 
625                 630                 635                 640 


Thr Leu Gln Glu Gly Gly Val Val Val Leu Leu Phe Ser Pro Gly Ala 
                645                 650                 655     


Val Ala Leu Cys Ser Glu Trp Leu Gln Asp Gly Val Ser Gly Pro Gly 
            660                 665                 670         


Ala His Gly Pro His Asp Ala Phe Arg Ala Ser Leu Ser Cys Val Leu 
        675                 680                 685             


Pro Asp Phe Leu Gln Gly Arg Ala Pro Gly Ser Tyr Val Gly Ala Cys 
    690                 695                 700                 


Phe Asp Arg Leu Leu His Pro Asp Ala Val Pro Ala Leu Phe Arg Thr 
705                 710                 715                 720 


Val Pro Val Phe Thr Leu Pro Ser Gln Leu Pro Asp Phe Leu Gly Ala 
                725                 730                 735     


Leu Gln Gln Pro Arg Ala Pro Arg Ser Gly Arg Leu Gln Glu Arg Ala 
            740                 745                 750         


Glu Gln Val Ser Arg Ala Leu Gln Pro Ala Leu Asp Ser Tyr Phe His 
        755                 760                 765             


Pro Pro Gly Thr Pro Ala Pro Gly Arg Gly Val Gly Pro Gly Ala Gly 
    770                 775                 780                 


Pro Gly Ala Gly Asp Gly Thr 
785                 790     


<210>  17
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  17

Gly Ile Thr Ile Pro Arg Asn Pro Gly Cys Pro Asn Ser Glu Asp Lys 
1               5                   10                  15      


Asn Phe Pro Arg Thr Val Met Val Asn Leu Asn Ile His Asn Arg Asn 
            20                  25                  30          


Thr Asn Thr Asn Pro Lys Arg Ser Ser Asp Tyr Tyr Asn Arg Ser Thr 
        35                  40                  45              


Ser Pro Trp Asn Leu His Arg Asn Glu Asp Pro Glu Arg Tyr Pro Ser 
    50                  55                  60                  


Val Ile Trp Glu Ala Lys Cys Arg His Leu Gly Cys Ile Asn Ala Asp 
65                  70                  75                  80  


Gly Asn Val Asp Tyr His Met Asn Ser Val Pro Ile Gln Gln Glu Ile 
                85                  90                  95      


Leu Val Leu Arg Arg Glu Pro Pro His Cys Pro Asn Ser Phe Arg Leu 
            100                 105                 110         


Glu Lys Ile Leu Val Ser Val Gly Cys Thr Cys Val Thr Pro Ile Val 
        115                 120                 125             


His His Val Ala Ser Gly Gly Gly Gly Ser Arg Gly Gly Leu Glu Val 
    130                 135                 140                 


Leu Phe Gln Gly Pro Glu Phe Gly Gly Ser Thr Thr Ala Pro Ser Ala 
145                 150                 155                 160 


Gln Leu Glu Lys Glu Leu Gln Ala Leu Glu Lys Glu Asn Ala Gln Leu 
                165                 170                 175     


Glu Trp Glu Leu Gln Ala Leu Glu Lys Glu Leu Ala Gln His His His 
            180                 185                 190         


His His His 
        195 


<210>  18
<211>  195
<212>  PRT
<213>  Homo sapiens

<400>  18

Gly Ile Thr Ile Pro Arg Asn Pro Gly Cys Pro Asn Ser Glu Asp Lys 
1               5                   10                  15      


Asn Phe Pro Arg Thr Val Met Val Asn Leu Asn Ile His Asn Arg Asn 
            20                  25                  30          


Thr Asn Thr Asn Pro Lys Arg Ser Ser Asp Tyr Tyr Asn Arg Ser Thr 
        35                  40                  45              


Ser Pro Trp Asn Leu His Arg Asn Glu Asp Pro Glu Arg Tyr Pro Ser 
    50                  55                  60                  


Val Ile Trp Glu Ala Lys Cys Arg His Leu Gly Cys Ile Asn Ala Asp 
65                  70                  75                  80  


Gly Asn Val Asp Tyr His Met Asn Ser Val Pro Ile Gln Gln Glu Ile 
                85                  90                  95      


Leu Val Leu Arg Arg Glu Pro Pro His Cys Pro Asn Ser Phe Arg Leu 
            100                 105                 110         


Glu Lys Ile Leu Val Ser Val Gly Cys Thr Cys Val Thr Pro Ile Val 
        115                 120                 125             


His His Val Ala Ser Gly Gly Gly Gly Ser Arg Gly Gly Leu Glu Val 
    130                 135                 140                 


Leu Phe Gln Gly Pro Glu Phe Gly Gly Ser Thr Thr Ala Pro Ser Ala 
145                 150                 155                 160 


Gln Leu Lys Lys Lys Leu Gln Ala Leu Lys Lys Lys Asn Ala Gln Leu 
                165                 170                 175     


Lys Trp Lys Leu Gln Ala Leu Lys Lys Lys Leu Ala Gln His His His 
            180                 185                 190         


His His His 
        195 


<210>  19
<211>  302
<212>  PRT
<213>  Homo sapiens

<400>  19

Gly Ile Thr Ile Pro Arg Asn Pro Gly Cys Pro Asn Ser Glu Asp Lys 
1               5                   10                  15      


Asn Phe Pro Arg Thr Val Met Val Asn Leu Asn Ile His Asn Arg Asn 
            20                  25                  30          


Thr Asn Thr Asn Pro Lys Arg Ser Ser Asp Tyr Tyr Asn Arg Ser Thr 
        35                  40                  45              


Ser Pro Trp Asn Leu His Arg Asn Glu Asp Pro Glu Arg Tyr Pro Ser 
    50                  55                  60                  


Val Ile Trp Glu Ala Lys Cys Arg His Leu Gly Cys Ile Asn Ala Asp 
65                  70                  75                  80  


Gly Asn Val Asp Tyr His Met Asn Ser Val Pro Ile Gln Gln Glu Ile 
                85                  90                  95      


Leu Val Leu Arg Arg Glu Pro Pro His Cys Pro Asn Ser Phe Arg Leu 
            100                 105                 110         


Glu Lys Ile Leu Val Ser Val Gly Cys Thr Cys Val Thr Pro Ile Val 
        115                 120                 125             


His His Val Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Ile Thr Ile Pro Arg Asn Pro Gly Cys Pro Asn Ser 
                165                 170                 175     


Glu Asp Lys Asn Phe Pro Arg Thr Val Met Val Asn Leu Asn Ile His 
            180                 185                 190         


Asn Arg Asn Thr Asn Thr Asn Pro Lys Arg Ser Ser Asp Tyr Tyr Asn 
        195                 200                 205             


Arg Ser Thr Ser Pro Trp Asn Leu His Arg Asn Glu Asp Pro Glu Arg 
    210                 215                 220                 


Tyr Pro Ser Val Ile Trp Glu Ala Lys Cys Arg His Leu Gly Cys Ile 
225                 230                 235                 240 


Asn Ala Asp Gly Asn Val Asp Tyr His Met Asn Ser Val Pro Ile Gln 
                245                 250                 255     


Gln Glu Ile Leu Val Leu Arg Arg Glu Pro Pro His Cys Pro Asn Ser 
            260                 265                 270         


Phe Arg Leu Glu Lys Ile Leu Val Ser Val Gly Cys Thr Cys Val Thr 
        275                 280                 285             


Pro Ile Val His His Val Ala Ser His His His His His His 
    290                 295                 300         


<210>  20
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  20

Gly Ile Thr Ile Pro Arg Asn Pro Gly Cys Pro Asn Ser Glu Asp Lys 
1               5                   10                  15      


Asn Phe Pro Arg Thr Val Met Val Asn Leu Asn Ile His Asn Arg Asn 
            20                  25                  30          


Thr Asn Thr Asn Pro Lys Arg Ser Ser Asp Tyr Tyr Asn Arg Ser Thr 
        35                  40                  45              


Ser Pro Trp Asn Leu His Arg Asn Glu Asp Pro Glu Arg Tyr Pro Ser 
    50                  55                  60                  


Val Ile Trp Glu Ala Lys Cys Arg His Leu Gly Cys Ile Asn Ala Asp 
65                  70                  75                  80  


Gly Asn Val Asp Tyr His Met Asn Ser Val Pro Ile Gln Gln Glu Ile 
                85                  90                  95      


Leu Val Leu Arg Arg Glu Pro Pro His Cys Pro Asn Ser Phe Arg Leu 
            100                 105                 110         


Glu Lys Ile Leu Val Ser Val Gly Cys Thr Cys Val Thr Pro Ile Val 
        115                 120                 125             


His His Val Ala 
    130         


<210>  21
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  21

Gly Ile Thr Ile Pro Arg Asn Pro Gly Cys Pro Asn Ser Glu Asp Lys 
1               5                   10                  15      


Asn Phe Pro Arg Thr Val Met Val Asn Leu Asn Ile His Asn Arg Asn 
            20                  25                  30          


Thr Asn Thr Asn Pro Lys Arg Ser Ser Asp Tyr Tyr Asn Glu Ser Thr 
        35                  40                  45              


Ser Pro Trp Asn Leu His Arg Asn Glu Asp Pro Glu Arg Tyr Pro Ser 
    50                  55                  60                  


Val Ile Trp Glu Ala Lys Cys Arg His Leu Gly Cys Ile Asn Ala Asp 
65                  70                  75                  80  


Gly Asn Val Asp Tyr His Met Asn Ser Val Pro Ile Gln Gln Glu Ile 
                85                  90                  95      


Leu Val Leu Arg Arg Glu Pro Pro His Cys Pro Asn Ser Phe Arg Leu 
            100                 105                 110         


Glu Lys Ile Leu Val Ser Val Gly Cys Thr Cys Val Thr Pro Ile Val 
        115                 120                 125             


His His Val Ala 
    130         


<210>  22
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  22

Gly Ile Thr Ile Pro Arg Asn Pro Gly Cys Pro Asn Ser Glu Asp Lys 
1               5                   10                  15      


Asn Phe Pro Arg Thr Val Met Val Asn Leu Asn Ile His Asn Arg Asn 
            20                  25                  30          


Thr Asn Thr Asn Pro Lys Arg Ser Ser Asp Tyr Tyr Asn Glu Ser Thr 
        35                  40                  45              


Ser Pro Trp Asn Leu His Arg Asn Glu Asp Pro Glu Arg Tyr Pro Lys 
    50                  55                  60                  


Val Ile Trp Glu Ala Lys Cys Arg His Leu Gly Cys Ile Asn Ala Asp 
65                  70                  75                  80  


Gly Asn Val Asp Tyr His Met Asn Ser Val Pro Ile Gln Gln Glu Ile 
                85                  90                  95      


Leu Val Leu Arg Arg Glu Pro Pro His Cys Pro Asn Ser Phe Arg Leu 
            100                 105                 110         


Glu Lys Ile Leu Val Ser Val Gly Cys Thr Cys Val Thr Pro Ile Val 
        115                 120                 125             


His His Val Ala 
    130         


<210>  23
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  23

Gly Ile Thr Ile Pro Arg Asn Pro Gly Cys Pro Asn Ser Glu Asp Lys 
1               5                   10                  15      


Asn Phe Pro Arg Thr Val Met Val Asn Leu Asn Ile His Asn Arg Asn 
            20                  25                  30          


Thr Asn Thr Asn Pro Lys Arg Ser Ser Asp Tyr Tyr Asn Glu Ser Thr 
        35                  40                  45              


Ser Pro Trp Asn Leu His Arg Asn Glu Asp Pro Glu Arg Tyr Pro Trp 
    50                  55                  60                  


Val Ile Trp Glu Ala Lys Cys Arg His Leu Gly Cys Ile Asn Ala Asp 
65                  70                  75                  80  


Gly Asn Val Asp Tyr His Met Asn Ser Val Pro Ile Gln Gln Glu Ile 
                85                  90                  95      


Leu Val Leu Arg Arg Glu Pro Pro His Cys Pro Asn Ser Phe Arg Leu 
            100                 105                 110         


Glu Lys Ile Leu Val Ser Val Gly Cys Thr Cys Val Thr Pro Ile Val 
        115                 120                 125             


His His Val Ala 
    130         


<210>  24
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  24

Gly Ile Thr Ile Pro Arg Asn Pro Gly Cys Pro Asn Ser Glu Asp Lys 
1               5                   10                  15      


Asn Phe Pro Arg Thr Val Met Val Asn Leu Asn Ile His Asn Arg Asn 
            20                  25                  30          


Thr Asn Thr Asn Pro Lys Arg Ser Ser Asp Tyr Tyr Asn Glu Ser Thr 
        35                  40                  45              


Ser Pro Trp Asn Leu His Arg Asn Glu Asp Pro Glu Arg Tyr Pro Ser 
    50                  55                  60                  


Val Ile Gln Glu Ala Lys Cys Arg His Leu Gly Cys Ile Asn Ala Asp 
65                  70                  75                  80  


Gly Asn Val Asp Tyr His Met Asn Ser Val Pro Ile Gln Gln Glu Ile 
                85                  90                  95      


Leu Val Leu Arg Arg Glu Pro Pro His Cys Pro Asn Ser Phe Arg Leu 
            100                 105                 110         


Glu Lys Ile Leu Val Ser Val Gly Cys Thr Cys Val Thr Pro Ile Val 
        115                 120                 125             


His His Val Ala 
    130         


<210>  25
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  25

Gly Ile Thr Ile Pro Arg Asn Pro Gly Cys Pro Asn Ser Glu Asp Lys 
1               5                   10                  15      


Asn Phe Pro Arg Thr Val Met Val Asn Leu Asn Ile His Asn Arg Asn 
            20                  25                  30          


Thr Asn Thr Asn Pro Lys Arg Ser Ser Asp Tyr Tyr Asn Glu Ser Thr 
        35                  40                  45              


Ser Pro Trp Asn Leu His Arg Asn Glu Asp Pro Glu Arg Tyr Pro Ser 
    50                  55                  60                  


Val Ile Trp Glu Ala Lys Cys Arg His Leu Gly Cys Ile Asn Ala Asp 
65                  70                  75                  80  


Gly Asn Val Asp Tyr His Met Asn Ser Val Pro Ile Gln Gln Glu Ile 
                85                  90                  95      


Leu Val Leu Arg Ala Glu Pro Pro His Cys Pro Asn Ser Phe Arg Leu 
            100                 105                 110         


Glu Lys Ile Leu Val Ser Val Gly Cys Thr Cys Val Thr Pro Ile Val 
        115                 120                 125             


His His Val Ala 
    130         


<210>  26
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  26

Gly Ile Thr Ile Pro Arg Asn Pro Gly Cys Pro Asn Ser Glu Asp Lys 
1               5                   10                  15      


Asn Phe Pro Arg Thr Val Met Val Asn Leu Asn Ile His Asn Arg Asn 
            20                  25                  30          


Thr Asn Thr Asn Pro Lys Arg Ser Ser Asp Tyr Tyr Asn Arg Ser Thr 
        35                  40                  45              


Ser Pro Trp Asn Leu His Arg Asn Glu Asp Pro Glu Arg Tyr Pro Ser 
    50                  55                  60                  


Val Ile Trp Glu Ala Lys Cys Arg His Leu Gly Cys Ile Asn Ala Asp 
65                  70                  75                  80  


Gly Asn Val Asp Tyr His Met Ala Ser Val Pro Ile Gln Gln Glu Ile 
                85                  90                  95      


Leu Val Leu Arg Arg Glu Pro Pro His Cys Pro Asn Ser Phe Arg Leu 
            100                 105                 110         


Glu Lys Ile Leu Val Ser Val Gly Cys Thr Cys Val Thr Pro Ile Val 
        115                 120                 125             


His His Val Ala 
    130         


<210>  27
<211>  126
<212>  PRT
<213>  Homo sapiens

<400>  27

Gly Ile Thr Ile Pro Arg Asn Pro Gly Cys Pro Asn Ser Glu Asp Lys 
1               5                   10                  15      


Asn Phe Pro Arg Thr Val Met Val Asn Leu Asn Ile His Asn Arg Asn 
            20                  25                  30          


Thr Asn Thr Asn Pro Lys Arg Ser Ser Asp Tyr Tyr Asn Arg Ser Thr 
        35                  40                  45              


Ser Pro Trp Asn Leu His Arg Asn Glu Asp Pro Glu Arg Tyr Pro Ser 
    50                  55                  60                  


Val Ile Trp Glu Ala Lys Cys Arg His Leu Gly Cys Ile Asn Ala Asp 
65                  70                  75                  80  


Gly Asn Val Asp Tyr His Met Ala Ser Val Pro Ile Gln Gln Glu Ile 
                85                  90                  95      


Leu Val Leu Arg Arg Glu Pro Pro His Cys Pro Asn Ser Phe Arg Leu 
            100                 105                 110         


Glu Lys Ile Leu Val Ser Val Gly Cys Thr Cys Val Thr Pro 
        115                 120                 125     


<210>  28
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  28

Arg Lys Ile Pro Lys Val Gly His Thr Phe Phe Gln Lys Pro Glu Ser 
1               5                   10                  15      


Cys Pro Pro Val Pro Gly Gly Ser Met Lys Leu Asp Ile Gly Ile Ile 
            20                  25                  30          


Asn Glu Asn Gln Arg Val Ser Met Ser Arg Asn Ile Glu Ser Glu Ser 
        35                  40                  45              


Thr Ser Pro Trp Asn Tyr Thr Val Thr Trp Asp Pro Asn Arg Tyr Pro 
    50                  55                  60                  


Ser Glu Val Val Gln Ala Gln Cys Arg Asn Leu Gly Cys Ile Asn Ala 
65                  70                  75                  80  


Gln Gly Lys Glu Asp Ile Ser Met Asn Ser Val Pro Ile Gln Gln Glu 
                85                  90                  95      


Thr Leu Val Val Arg Arg Lys His Gln Gly Cys Ser Val Ser Phe Gln 
            100                 105                 110         


Leu Glu Lys Val Leu Val Thr Val Gly Cys Thr Cys Val Thr Pro Val 
        115                 120                 125             


Ile His His Val Gln 
    130             


<210>  29
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  29

Arg Lys Ile Pro Lys Val Gly His Thr Phe Phe Gln Lys Pro Glu Ser 
1               5                   10                  15      


Cys Pro Pro Val Pro Gly Gly Ser Met Lys Leu Asp Ile Gly Ile Ile 
            20                  25                  30          


Asn Glu Asn Gln Arg Val Ser Met Ser Arg Asn Ile Glu Ser Glu Ser 
        35                  40                  45              


Thr Ser Pro Trp Asn Tyr Thr Val Thr Trp Asp Pro Asn Arg Tyr Pro 
    50                  55                  60                  


Lys Glu Val Val Gln Ala Gln Cys Arg Asn Leu Gly Cys Ile Asn Ala 
65                  70                  75                  80  


Gln Gly Lys Glu Asp Ile Ser Met Asn Ser Val Pro Ile Gln Gln Glu 
                85                  90                  95      


Thr Leu Val Val Arg Arg Lys His Gln Gly Cys Ser Val Ser Phe Gln 
            100                 105                 110         


Leu Glu Lys Val Leu Val Thr Val Gly Cys Thr Cys Val Thr Pro Val 
        115                 120                 125             


Ile His His Val 
    130         


<210>  30
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  30

Arg Lys Ile Pro Lys Val Gly His Thr Phe Phe Gln Lys Pro Glu Ser 
1               5                   10                  15      


Cys Pro Pro Val Pro Gly Gly Ser Met Lys Leu Asp Ile Gly Ile Ile 
            20                  25                  30          


Asn Glu Asn Gln Arg Val Ser Met Ser Arg Asn Ile Glu Ser Glu Ser 
        35                  40                  45              


Thr Ser Pro Trp Asn Tyr Thr Val Thr Trp Asp Pro Asn Arg Tyr Pro 
    50                  55                  60                  


Trp Glu Val Val Gln Ala Gln Cys Arg Asn Leu Gly Cys Ile Asn Ala 
65                  70                  75                  80  


Gln Gly Lys Glu Asp Ile Ser Met Asn Ser Val Pro Ile Gln Gln Glu 
                85                  90                  95      


Thr Leu Val Val Arg Arg Lys His Gln Gly Cys Ser Val Ser Phe Gln 
            100                 105                 110         


Leu Glu Lys Val Leu Val Thr Val Gly Cys Thr Cys Val Thr Pro Val 
        115                 120                 125             


Ile His His Val Gln 
    130             


<210>  31
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  31

Arg Lys Ile Pro Lys Val Gly His Thr Phe Phe Gln Lys Pro Glu Ser 
1               5                   10                  15      


Cys Pro Pro Val Pro Gly Gly Ser Met Lys Leu Asp Ile Gly Ile Ile 
            20                  25                  30          


Asn Glu Asn Gln Arg Val Ser Met Ser Arg Asn Ile Glu Ser Glu Ser 
        35                  40                  45              


Thr Ser Pro Trp Asn Tyr Thr Val Thr Trp Asp Pro Asn Arg Tyr Pro 
    50                  55                  60                  


Ser Glu Val Gln Gln Ala Gln Cys Arg Asn Leu Gly Cys Ile Asn Ala 
65                  70                  75                  80  


Gln Gly Lys Glu Asp Ile Ser Met Asn Ser Val Pro Ile Gln Gln Glu 
                85                  90                  95      


Thr Leu Val Val Arg Arg Lys His Gln Gly Cys Ser Val Ser Phe Gln 
            100                 105                 110         


Leu Glu Lys Val Leu Val Thr Val Gly Cys Thr Cys Val Thr Pro Val 
        115                 120                 125             


Ile His His Val Gln 
    130             


<210>  32
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  32

Arg Lys Ile Pro Lys Val Gly His Thr Phe Phe Gln Lys Pro Glu Ser 
1               5                   10                  15      


Cys Pro Pro Val Pro Gly Gly Ser Met Lys Leu Asp Ile Gly Ile Ile 
            20                  25                  30          


Asn Glu Asn Gln Arg Val Ser Met Ser Arg Asn Ile Glu Ser Glu Ser 
        35                  40                  45              


Thr Ser Pro Trp Asn Tyr Thr Val Thr Trp Asp Pro Asn Arg Tyr Pro 
    50                  55                  60                  


Ser Glu Val Val Gln Ala Gln Cys Arg Asn Leu Gly Cys Ile Asn Ala 
65                  70                  75                  80  


Gln Gly Lys Glu Asp Ile Ser Met Asn Ser Val Pro Ile Gln Gln Glu 
                85                  90                  95      


Thr Leu Val Val Arg Ala Lys His Gln Gly Cys Ser Val Ser Phe Gln 
            100                 105                 110         


Leu Glu Lys Val Leu Val Thr Val Gly Cys Thr Cys Val Thr Pro Val 
        115                 120                 125             


Ile His His Val Gln 
    130             


<210>  33
<211>  133
<212>  PRT
<213>  Homo sapiens

<400>  33

Arg Lys Ile Pro Lys Val Gly His Thr Phe Phe Gln Lys Pro Glu Ser 
1               5                   10                  15      


Cys Pro Pro Val Pro Gly Gly Ser Met Lys Leu Asp Ile Gly Ile Ile 
            20                  25                  30          


Asn Glu Asn Gln Arg Val Ser Met Ser Arg Asn Ile Glu Ser Glu Ser 
        35                  40                  45              


Thr Ser Pro Trp Asn Tyr Thr Val Thr Trp Asp Pro Asn Arg Tyr Pro 
    50                  55                  60                  


Ser Glu Val Val Gln Ala Gln Cys Arg Asn Leu Gly Cys Ile Asn Ala 
65                  70                  75                  80  


Gln Gly Lys Glu Asp Ile Ser Met Asn Ser Val Pro Ile Gln Gln Glu 
                85                  90                  95      


Thr Leu Val Val Arg Ala Lys His Gln Gly Cys Ser Val Ser Phe Gln 
            100                 105                 110         


Leu Glu Lys Val Leu Val Thr Val Gly Cys Thr Cys Val Thr Pro Val 
        115                 120                 125             


Ile His His Val Gln 
    130             


<210>  34
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  34

Arg Ser Pro Lys Ser Lys Arg Lys Gly Gln Gly Arg Pro Gly Pro Leu 
1               5                   10                  15      


Ala Pro Gly Pro His Gln Val Pro Leu Asp Leu Val Ser Arg Met Lys 
            20                  25                  30          


Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg Asn Ile Glu Glu Met Val 
        35                  40                  45              


Ala Gln Leu Arg Asn Ser Ser Glu Leu Ala Gln Arg Lys Cys Glu Val 
    50                  55                  60                  


Asn Leu Gln Leu Trp Met Ser Asn Lys Glu Ser Leu Ser Pro Trp Gly 
65                  70                  75                  80  


Tyr Ser Ile Asn His Asp Pro Ser Arg Ile Pro Val Asp Leu Pro Glu 
                85                  90                  95      


Ala Arg Cys Leu Cys Leu Gly Cys Val Asn Pro Phe Thr Met Gln Glu 
            100                 105                 110         


Asp Arg Ser Met Val Ser Val Pro Val Phe Ser Gln Val Pro Val Arg 
        115                 120                 125             


Arg Arg Leu Cys Pro Pro Pro Pro Arg Thr Gly Pro Cys Arg Gln Arg 
    130                 135                 140                 


Ala Val Met Glu Thr Ile Ala Val Gly Cys Thr Cys Ile Phe 
145                 150                 155             


<210>  35
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  35

Arg Ser Pro Lys Ser Lys Arg Lys Gly Gln Gly Arg Pro Gly Pro Leu 
1               5                   10                  15      


Ala Pro Gly Pro His Gln Val Pro Leu Asp Leu Val Ser Arg Met Lys 
            20                  25                  30          


Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg Asn Ile Glu Glu Met Val 
        35                  40                  45              


Ala Gln Leu Arg Asn Ser Ser Glu Leu Ala Gln Arg Lys Cys Glu Val 
    50                  55                  60                  


Asn Leu Gln Leu Trp Met Ser Asn Lys Glu Ser Leu Ser Pro Trp Gly 
65                  70                  75                  80  


Tyr Ser Ile Asn His Asp Pro Ser Arg Ile Pro Val Asp Leu Pro Glu 
                85                  90                  95      


Ala Arg Cys Leu Cys Leu Gly Cys Val Asn Pro Phe Thr Met Gln Glu 
            100                 105                 110         


Asp Arg Ser Met Val Ser Val Pro Val Phe Ser Gln Val Pro Val Arg 
        115                 120                 125             


Arg Ala Leu Cys Pro Pro Pro Pro Arg Thr Gly Pro Cys Arg Gln Arg 
    130                 135                 140                 


Ala Val Met Glu Thr Ile Ala Val Gly Cys Thr Cys Ile Phe 
145                 150                 155             


<210>  36
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  36

Arg Ser Pro Lys Ser Lys Arg Lys Gly Gln Gly Arg Pro Gly Pro Leu 
1               5                   10                  15      


Ala Pro Gly Pro His Gln Val Pro Leu Asp Leu Val Ser Arg Met Lys 
            20                  25                  30          


Pro Tyr Ala Arg Met Glu Glu Tyr Glu Arg Asn Ile Glu Glu Met Val 
        35                  40                  45              


Ala Gln Leu Arg Asn Ser Ser Glu Leu Ala Gln Arg Lys Cys Glu Val 
    50                  55                  60                  


Asn Leu Gln Leu Trp Met Ser Asn Lys Arg Ser Leu Ser Pro Trp Gly 
65                  70                  75                  80  


Tyr Ser Ile Asn His Asp Pro Ser Arg Ile Pro Val Asp Leu Pro Glu 
                85                  90                  95      


Ala Arg Cys Leu Cys Leu Gly Cys Val Asn Pro Phe Thr Met Gln Glu 
            100                 105                 110         


Asp Arg Ser Met Ala Ser Val Pro Val Phe Ser Gln Val Pro Val Arg 
        115                 120                 125             


Arg Arg Leu Cys Pro Pro Pro Pro Arg Thr Gly Pro Cys Arg Gln Arg 
    130                 135                 140                 


Ala Val Met Glu Thr Ile Ala Val Gly Cys Thr Cys Ile Phe 
145                 150                 155             


<210>  37
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  37

His His Asp Pro Ser Leu Arg Gly His Pro His Ser His Gly Thr Pro 
1               5                   10                  15      


His Cys Tyr Ser Ala Glu Glu Leu Pro Leu Gly Gln Ala Pro Pro His 
            20                  25                  30          


Leu Leu Ala Arg Gly Ala Lys Trp Gly Gln Ala Leu Pro Val Ala Leu 
        35                  40                  45              


Val Ser Ser Leu Glu Ala Ala Ser His Arg Gly Arg His Glu Arg Pro 
    50                  55                  60                  


Ser Ala Thr Thr Gln Cys Pro Val Leu Arg Pro Glu Glu Val Leu Glu 
65                  70                  75                  80  


Ala Asp Thr His Gln Glu Ser Ile Ser Pro Trp Arg Tyr Arg Val Asp 
                85                  90                  95      


Thr Asp Glu Asp Arg Tyr Pro Gln Lys Leu Ala Phe Ala Glu Cys Leu 
            100                 105                 110         


Cys Arg Gly Cys Ile Asp Ala Arg Thr Gly Arg Glu Thr Ala Ala Leu 
        115                 120                 125             


Asn Ser Val Arg Leu Leu Gln Ser Leu Leu Val Leu Arg Arg Arg Pro 
    130                 135                 140                 


Cys Ser Arg Asp Gly Ser Gly Leu Pro Thr Pro Gly Ala Phe Ala Phe 
145                 150                 155                 160 


His Thr Glu Phe Ile His Val Pro Val Gly Cys Thr Cys Val Leu Pro 
                165                 170                 175     


Arg Ser Val 
            


<210>  38
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  38

His His Asp Pro Ser Leu Arg Gly His Pro His Ser His Gly Thr Pro 
1               5                   10                  15      


His Cys Tyr Ser Ala Glu Glu Leu Pro Leu Gly Gln Ala Pro Pro His 
            20                  25                  30          


Leu Leu Ala Arg Gly Ala Lys Trp Gly Gln Ala Leu Pro Val Ala Leu 
        35                  40                  45              


Val Ser Ser Leu Glu Ala Ala Ser His Arg Gly Arg His Glu Arg Pro 
    50                  55                  60                  


Ser Ala Thr Thr Gln Cys Pro Val Leu Arg Pro Glu Glu Val Leu Glu 
65                  70                  75                  80  


Ala Asp Thr His Gln Glu Ser Ile Ser Pro Trp Arg Tyr Arg Val Asp 
                85                  90                  95      


Thr Asp Glu Asp Arg Tyr Pro Gln Lys Leu Ala Phe Ala Glu Cys Leu 
            100                 105                 110         


Cys Arg Gly Cys Ile Asp Ala Arg Thr Gly Arg Glu Thr Ala Ala Leu 
        115                 120                 125             


Asn Ser Val Arg Leu Leu Gln Ser Leu Leu Val Leu Arg Ala Arg Pro 
    130                 135                 140                 


Cys Ser Arg Asp Gly Ser Gly Leu Pro Thr Pro Gly Ala Phe Ala Phe 
145                 150                 155                 160 


His Thr Glu Phe Ile His Val Pro Val Gly Cys Thr Cys Val Leu Pro 
                165                 170                 175     


Arg Ser Val 
            


<210>  39
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  39

His His Asp Pro Ser Leu Arg Gly His Pro His Ser His Gly Thr Pro 
1               5                   10                  15      


His Cys Tyr Ser Ala Glu Glu Leu Pro Leu Gly Gln Ala Pro Pro His 
            20                  25                  30          


Leu Leu Ala Arg Gly Ala Lys Trp Gly Gln Ala Leu Pro Val Ala Leu 
        35                  40                  45              


Val Ser Ser Leu Glu Ala Ala Ser His Arg Gly Arg His Glu Arg Pro 
    50                  55                  60                  


Ser Ala Thr Thr Gln Cys Pro Val Leu Arg Pro Glu Glu Val Leu Glu 
65                  70                  75                  80  


Ala Asp Thr His Gln Arg Ser Ile Ser Pro Trp Arg Tyr Arg Val Asp 
                85                  90                  95      


Thr Asp Glu Asp Arg Tyr Pro Gln Lys Leu Ala Phe Ala Glu Cys Leu 
            100                 105                 110         


Cys Arg Gly Cys Ile Asp Ala Arg Thr Gly Arg Glu Thr Ala Ala Leu 
        115                 120                 125             


Ala Ser Val Arg Leu Leu Gln Ser Leu Leu Val Leu Arg Arg Arg Pro 
    130                 135                 140                 


Cys Ser Arg Asp Gly Ser Gly Leu Pro Thr Pro Gly Ala Phe Ala Phe 
145                 150                 155                 160 


His Thr Glu Phe Ile His Val Pro Val Gly Cys Thr Cys Val Leu Pro 
                165                 170                 175     


Arg Ser Val 
            


<210>  40
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  40

Ala Gly Ala Pro Arg Ala Gly Arg Arg Pro Ala Arg Pro Arg Gly Cys 
1               5                   10                  15      


Ala Asp Arg Pro Glu Glu Leu Leu Glu Gln Leu Tyr Gly Arg Leu Ala 
            20                  25                  30          


Ala Gly Val Leu Ser Ala Phe His His Thr Leu Gln Leu Gly Pro Arg 
        35                  40                  45              


Glu Gln Ala Arg Asn Ala Ser Cys Pro Ala Gly Gly Arg Pro Ala Asp 
    50                  55                  60                  


Arg Arg Phe Arg Pro Pro Thr Asn Leu Glu Ser Val Ser Pro Trp Ala 
65                  70                  75                  80  


Tyr Arg Ile Ser Tyr Asp Pro Ala Arg Tyr Pro Arg Tyr Leu Pro Glu 
                85                  90                  95      


Ala Tyr Cys Leu Cys Arg Gly Cys Leu Thr Gly Leu Phe Gly Glu Glu 
            100                 105                 110         


Asp Val Arg Phe Arg Ser Ala Pro Val Tyr Met Pro Thr Val Val Leu 
        115                 120                 125             


Arg Arg Thr Pro Ala Cys Ala Gly Gly Arg Ser Val Tyr Thr Glu Ala 
    130                 135                 140                 


Tyr Val Thr Ile Pro Val Gly Cys Thr Cys Val Pro Glu Pro Glu Lys 
145                 150                 155                 160 


Asp Ala Asp Ser Ile Asn Ser Ser Ile Asp Lys Gln Gly Ala Lys Leu 
                165                 170                 175     


Leu Leu Gly Pro Asn Asp Ala Pro Ala Gly Pro 
            180                 185         


<210>  41
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  41

Ala Gly Ala Pro Arg Ala Gly Arg Arg Pro Ala Arg Pro Arg Gly Cys 
1               5                   10                  15      


Ala Asp Arg Pro Glu Glu Leu Leu Glu Gln Leu Tyr Gly Arg Leu Ala 
            20                  25                  30          


Ala Gly Val Leu Ser Ala Phe His His Thr Leu Gln Leu Gly Pro Arg 
        35                  40                  45              


Glu Gln Ala Arg Asn Ala Ser Cys Pro Ala Gly Gly Arg Pro Ala Asp 
    50                  55                  60                  


Arg Arg Phe Arg Pro Pro Thr Asn Leu Glu Ser Val Ser Pro Trp Ala 
65                  70                  75                  80  


Tyr Arg Ile Ser Tyr Asp Pro Ala Arg Tyr Pro Arg Tyr Leu Pro Glu 
                85                  90                  95      


Ala Tyr Cys Leu Cys Arg Gly Cys Leu Thr Gly Leu Phe Gly Glu Glu 
            100                 105                 110         


Asp Val Arg Phe Arg Ser Ala Pro Val Tyr Met Pro Thr Val Val Leu 
        115                 120                 125             


Arg Ala Thr Pro Ala Cys Ala Gly Gly Arg Ser Val Tyr Thr Glu Ala 
    130                 135                 140                 


Tyr Val Thr Ile Pro Val Gly Cys Thr Cys Val Pro Glu Pro Glu Lys 
145                 150                 155                 160 


Asp Ala Asp Ser Ile Asn Ser Ser Ile Asp Lys Gln Gly Ala Lys Leu 
                165                 170                 175     


Leu Leu Gly Pro Asn Asp Ala Pro Ala Gly Pro 
            180                 185         


<210>  42
<211>  187
<212>  PRT
<213>  Homo sapiens

<400>  42

Ala Gly Ala Pro Arg Ala Gly Arg Arg Pro Ala Arg Pro Arg Gly Cys 
1               5                   10                  15      


Ala Asp Arg Pro Glu Glu Leu Leu Glu Gln Leu Tyr Gly Arg Leu Ala 
            20                  25                  30          


Ala Gly Val Leu Ser Ala Phe His His Thr Leu Gln Leu Gly Pro Arg 
        35                  40                  45              


Glu Gln Ala Arg Asn Ala Ser Cys Pro Ala Gly Gly Arg Pro Ala Asp 
    50                  55                  60                  


Arg Arg Phe Arg Pro Pro Thr Asn Leu Arg Ser Val Ser Pro Trp Ala 
65                  70                  75                  80  


Tyr Arg Ile Ser Tyr Asp Pro Ala Arg Tyr Pro Arg Tyr Leu Pro Glu 
                85                  90                  95      


Ala Tyr Cys Leu Cys Arg Gly Cys Leu Thr Gly Leu Phe Gly Glu Glu 
            100                 105                 110         


Asp Val Arg Phe Ala Ser Ala Pro Val Tyr Met Pro Thr Val Val Leu 
        115                 120                 125             


Arg Arg Thr Pro Ala Cys Ala Gly Gly Arg Ser Val Tyr Thr Glu Ala 
    130                 135                 140                 


Tyr Val Thr Ile Pro Val Gly Cys Thr Cys Val Pro Glu Pro Glu Lys 
145                 150                 155                 160 


Asp Ala Asp Ser Ile Asn Ser Ser Ile Asp Lys Gln Gly Ala Lys Leu 
                165                 170                 175     


Leu Leu Gly Pro Asn Asp Ala Pro Ala Gly Pro 
            180                 185         


<210>  43
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  43

Thr His Thr Tyr Ser His Trp Pro Ser Cys Cys Pro Ser Lys Gly Gln 
1               5                   10                  15      


Asp Thr Ser Glu Glu Leu Leu Arg Trp Ser Thr Val Pro Val Pro Pro 
            20                  25                  30          


Leu Glu Pro Ala Arg Pro Asn Arg His Pro Glu Ser Cys Arg Ala Ser 
        35                  40                  45              


Glu Asp Gly Pro Leu Asn Ser Glu Ala Ile Ser Pro Trp Arg Tyr Glu 
    50                  55                  60                  


Leu Asp Arg Asp Leu Asn Arg Leu Pro Gln Asp Leu Tyr His Ala Arg 
65                  70                  75                  80  


Cys Leu Cys Pro His Cys Val Ser Leu Gln Thr Gly Ser His Met Asp 
                85                  90                  95      


Pro Arg Gly Asn Ser Glu Leu Leu Tyr His Asn Gln Thr Val Phe Tyr 
            100                 105                 110         


Arg Arg Pro Cys His Gly Glu Lys Gly Thr His Lys Gly Tyr Cys Leu 
        115                 120                 125             


Glu Arg Arg Leu Tyr Arg Val Ser Leu Ala Cys Val Cys Val Arg Pro 
    130                 135                 140                 


Arg Val Met Gly 
145             


<210>  44
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  44

Thr His Thr Tyr Ser His Trp Pro Ser Cys Cys Pro Ser Lys Gly Gln 
1               5                   10                  15      


Asp Thr Ser Glu Glu Leu Leu Arg Trp Ser Thr Val Pro Val Pro Pro 
            20                  25                  30          


Leu Glu Pro Ala Arg Pro Asn Arg His Pro Glu Ser Cys Arg Ala Ser 
        35                  40                  45              


Glu Asp Gly Pro Leu Asn Ser Glu Ala Ile Ser Pro Trp Arg Tyr Glu 
    50                  55                  60                  


Leu Asp Arg Asp Leu Asn Arg Leu Pro Gln Asp Leu Tyr His Ala Arg 
65                  70                  75                  80  


Cys Leu Cys Pro His Cys Val Ser Leu Gln Thr Gly Ser His Met Asp 
                85                  90                  95      


Pro Arg Gly Asn Ser Glu Leu Leu Tyr His Asn Gln Thr Val Phe Tyr 
            100                 105                 110         


Ala Arg Pro Cys His Gly Glu Lys Gly Thr His Lys Gly Tyr Cys Leu 
        115                 120                 125             


Glu Arg Arg Leu Tyr Arg Val Ser Leu Ala Cys Val Cys Val Arg Pro 
    130                 135                 140                 


Arg Val Met Gly 
145             


<210>  45
<211>  148
<212>  PRT
<213>  Homo sapiens

<400>  45

Thr His Thr Tyr Ser His Trp Pro Ser Cys Cys Pro Ser Lys Gly Gln 
1               5                   10                  15      


Asp Thr Ser Glu Glu Leu Leu Arg Trp Ser Thr Val Pro Val Pro Pro 
            20                  25                  30          


Leu Glu Pro Ala Arg Pro Asn Arg His Pro Glu Ser Cys Arg Ala Ser 
        35                  40                  45              


Glu Asp Gly Pro Leu Asn Ser Arg Ala Ile Ser Pro Trp Arg Tyr Glu 
    50                  55                  60                  


Leu Asp Arg Asp Leu Asn Arg Leu Pro Gln Asp Leu Tyr His Ala Arg 
65                  70                  75                  80  


Cys Leu Cys Pro His Cys Val Ser Leu Gln Thr Gly Ser His Met Asp 
                85                  90                  95      


Pro Arg Gly Ala Ser Glu Leu Leu Tyr His Asn Gln Thr Val Phe Tyr 
            100                 105                 110         


Arg Arg Pro Cys His Gly Glu Lys Gly Thr His Lys Gly Tyr Cys Leu 
        115                 120                 125             


Glu Arg Arg Leu Tyr Arg Val Ser Leu Ala Cys Val Cys Val Arg Pro 
    130                 135                 140                 


Arg Val Met Gly 
145             


<210>  46
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  46

Gly Ile Thr Ile Pro Arg Asn Pro Gly Cys Pro Asn Ser Glu Asp Lys 
1               5                   10                  15      


Asn Phe Pro Arg Thr Val Met Val Asn Leu Asn Ile His Asn Arg Asn 
            20                  25                  30          


Thr Asn Thr Asn Pro Lys Arg Ser Ser Asp Tyr Tyr Asn Glu Ser Thr 
        35                  40                  45              


Ser Pro Trp Asn Leu His Arg Asn Glu Asp Pro Glu Arg Tyr Pro Lys 
    50                  55                  60                  


Val Ile Trp Glu Ala Lys Cys Arg His Leu Gly Cys Ile Asn Ala Asp 
65                  70                  75                  80  


Gly Asn Val Asp Tyr His Met Asn Ser Val Pro Ile Gln Gln Glu Ile 
                85                  90                  95      


Leu Val Leu Arg Arg Glu Pro Pro His Cys Pro Asn Ser Phe Arg Leu 
            100                 105                 110         


Glu Lys Ile Leu Val Ser Val Gly Cys Thr Cys Val Thr Pro Ile Val 
        115                 120                 125             


His His Val Ala Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
    130                 135                 140                 


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly 
145                 150                 155                 160 


Gly Gly Ser Gly Ile Thr Ile Pro Arg Asn Pro Gly Cys Pro Asn Ser 
                165                 170                 175     


Glu Asp Lys Asn Phe Pro Arg Thr Val Met Val Asn Leu Asn Ile His 
            180                 185                 190         


Asn Arg Asn Thr Asn Thr Asn Pro Lys Arg Ser Ser Asp Tyr Tyr Asn 
        195                 200                 205             


Arg Ser Thr Ser Pro Trp Asn Leu His Arg Asn Glu Asp Pro Glu Arg 
    210                 215                 220                 


Tyr Pro Ser Val Ile Trp Glu Ala Lys Cys Arg His Leu Gly Cys Ile 
225                 230                 235                 240 


Asn Ala Asp Gly Asn Val Asp Tyr His Met Ala Ser Val Pro Ile Gln 
                245                 250                 255     


Gln Glu Ile Leu Val Leu Arg Arg Glu Pro Pro His Cys Pro Asn Ser 
            260                 265                 270         


Phe Arg Leu Glu Lys Ile Leu Val Ser Val Gly Cys Thr Cys Val Thr 
        275                 280                 285             


Pro Ala Ser His His His His His His 
    290                 295         


