                         SEQUENCE LISTING

<110>  The Trustees of Columbia University In The City Of New York
 
<120>  RAGE Regulates ROCK Activity in Cardiovascular Disease

<130>  80268


<160>  44    

<170>  PatentIn version 3.5

<210>  1
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys 
    130                 135                 140                 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp 
145                 150                 155                 160 


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
                165                 170                 175     


Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu 
            180                 185                 190         


Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys 
        195                 200                 205             


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro 
    210                 215                 220                 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
225                 230                 235                 240 


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr 
                245                 250                 255     


Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
            260                 265                 270         


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
        275                 280                 285             


Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr 
    290                 295                 300                 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
305                 310                 315                 320 


Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly Ser Val Gly Gly Ser 
                325                 330                 335     


Gly Leu Gly Thr Leu Ala Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly 
            340                 345                 350         


Thr Ala Ala Leu Leu Ile Gly Val Ile Leu Trp Gln Arg Arg Gln Arg 
        355                 360                 365             


Arg Gly Glu Glu Arg Lys Ala Pro Glu Asn Gln Glu Glu Glu Glu Glu 
    370                 375                 380                 


Arg Ala Glu Leu Asn Gln Ser Glu Glu Pro Glu Ala Gly Glu Ser Ser 
385                 390                 395                 400 


Thr Gly Gly Pro 
                


<210>  2
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu Pro Leu Val Leu Lys Cys 
1               5                   10                  15      


Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg Leu Glu Trp Lys Leu Asn 
            20                  25                  30          


Thr Gly Arg Thr Glu Ala Trp Lys Val Leu Ser Pro Gln Gly Gly Gly 
        35                  40                  45              


Pro Trp Asp Ser Val Ala Arg Val Leu Pro Asn Gly Ser Leu Phe Leu 
    50                  55                  60                  


Pro Ala Val Gly Ile Gln Asp Glu Gly Ile Phe Arg Cys Gln Ala Met 
65                  70                  75                  80  


Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn Tyr Arg Val Arg Val Tyr 
                85                  90                  95      


Gln Ile Pro Gly Lys Pro Glu Ile Val Asp Ser Ala Ser Glu Leu Thr 
            100                 105                 110         


Ala Gly Val Pro Asn Lys Val Gly Thr Cys Val Ser Glu Gly Ser Tyr 
        115                 120                 125             


Pro Ala Gly Thr Leu Ser Trp His Leu Asp Gly Lys Pro Leu Val Pro 
    130                 135                 140                 


Asn Glu Lys Gly Val Ser Val Lys Glu Gln Thr Arg Arg His Pro Glu 
145                 150                 155                 160 


Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu Met Val Thr Pro Ala Arg 
                165                 170                 175     


Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys Ser Phe Ser Pro Gly Leu 
            180                 185                 190         


Pro Arg His Arg Ala Leu Arg Thr Ala Pro Ile Gln Pro Arg Val Trp 
        195                 200                 205             


Glu Pro Val Pro Leu Glu Glu Val Gln Leu Val Val Glu Pro Glu Gly 
    210                 215                 220                 


Gly Ala Val Ala Pro Gly Gly Thr Val Thr Leu Thr Cys Glu Val Pro 
225                 230                 235                 240 


Ala Gln Pro Ser Pro Gln Ile His Trp Met Lys Asp Gly Val Pro Leu 
                245                 250                 255     


Pro Leu Pro Pro Ser Pro Val Leu Ile Leu Pro Glu Ile Gly Pro Gln 
            260                 265                 270         


Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr His Ser Ser His Gly Pro 
        275                 280                 285             


Gln Glu Ser Arg Ala Val Ser Ile Ser Ile Ile Glu Pro Gly Glu Glu 
    290                 295                 300                 


Gly Pro Thr Ala Gly Ser Val Gly Gly Ser Gly Leu Gly Thr Leu Ala 
305                 310                 315                 320 


Leu Ala Leu Gly Ile Leu Gly Gly Leu Gly Thr Ala Ala Leu Leu Ile 
                325                 330                 335     


Gly Val Ile Leu Trp Gln Arg Arg Gln Arg Arg Gly Glu Glu Arg Lys 
            340                 345                 350         


Ala Pro Glu Asn Gln Glu Glu Glu Glu Glu Arg Ala Glu Leu Asn Gln 
        355                 360                 365             


Ser Glu Glu Pro Glu Ala Gly Glu Ser Ser Thr Gly Gly Pro 
    370                 375                 380         


<210>  3
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  3

Gln Asn Ile Thr Ala Arg Ile Gly Glu Pro Leu Val Leu Lys Cys Lys 
1               5                   10                  15      


Gly Ala Pro Lys Lys Pro Pro Gln Arg Leu Glu Trp Lys Leu Asn Thr 
            20                  25                  30          


Gly Arg Thr Glu Ala Trp Lys Val Leu Ser Pro Gln Gly Gly Gly Pro 
        35                  40                  45              


Trp Asp Ser Val Ala Arg Val Leu Pro Asn Gly Ser Leu Phe Leu Pro 
    50                  55                  60                  


Ala Val Gly Ile Gln Asp Glu Gly Ile Phe Arg Cys Gln Ala Met Asn 
65                  70                  75                  80  


Arg Asn Gly Lys Glu Thr Lys Ser Asn Tyr Arg Val Arg Val Tyr Gln 
                85                  90                  95      


Ile Pro Gly Lys Pro Glu Ile Val Asp Ser Ala Ser Glu Leu Thr Ala 
            100                 105                 110         


Gly Val Pro Asn Lys Val Gly Thr Cys Val Ser Glu Gly Ser Tyr Pro 
        115                 120                 125             


Ala Gly Thr Leu Ser Trp His Leu Asp Gly Lys Pro Leu Val Pro Asn 
    130                 135                 140                 


Glu Lys Gly Val Ser Val Lys Glu Gln Thr Arg Arg His Pro Glu Thr 
145                 150                 155                 160 


Gly Leu Phe Thr Leu Gln Ser Glu Leu Met Val Thr Pro Ala Arg Gly 
                165                 170                 175     


Gly Asp Pro Arg Pro Thr Phe Ser Cys Ser Phe Ser Pro Gly Leu Pro 
            180                 185                 190         


Arg His Arg Ala Leu Arg Thr Ala Pro Ile Gln Pro Arg Val Trp Glu 
        195                 200                 205             


Pro Val Pro Leu Glu Glu Val Gln Leu Val Val Glu Pro Glu Gly Gly 
    210                 215                 220                 


Ala Val Ala Pro Gly Gly Thr Val Thr Leu Thr Cys Glu Val Pro Ala 
225                 230                 235                 240 


Gln Pro Ser Pro Gln Ile His Trp Met Lys Asp Gly Val Pro Leu Pro 
                245                 250                 255     


Leu Pro Pro Ser Pro Val Leu Ile Leu Pro Glu Ile Gly Pro Gln Asp 
            260                 265                 270         


Gln Gly Thr Tyr Ser Cys Val Ala Thr His Ser Ser His Gly Pro Gln 
        275                 280                 285             


Glu Ser Arg Ala Val Ser Ile Ser Ile Ile Glu Pro Gly Glu Glu Gly 
    290                 295                 300                 


Pro Thr Ala Gly Ser Val Gly Gly Ser Gly Leu Gly Thr Leu Ala Leu 
305                 310                 315                 320 


Ala Leu Gly Ile Leu Gly Gly Leu Gly Thr Ala Ala Leu Leu Ile Gly 
                325                 330                 335     


Val Ile Leu Trp Gln Arg Arg Gln Arg Arg Gly Glu Glu Arg Lys Ala 
            340                 345                 350         


Pro Glu Asn Gln Glu Glu Glu Glu Glu Arg Ala Glu Leu Asn Gln Ser 
        355                 360                 365             


Glu Glu Pro Glu Ala Gly Glu Ser Ser Thr Gly Gly Pro 
    370                 375                 380     


<210>  4
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys 
    130                 135                 140                 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp 
145                 150                 155                 160 


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
                165                 170                 175     


Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu 
            180                 185                 190         


Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys 
        195                 200                 205             


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro 
    210                 215                 220                 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
225                 230                 235                 240 


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr 
                245                 250                 255     


Leu Thr Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met 
            260                 265                 270         


Lys Asp Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu 
        275                 280                 285             


Pro Glu Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr 
    290                 295                 300                 


His Ser Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser Ile Ser Ile 
305                 310                 315                 320 


Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly Ser Val Gly Gly Ser 
                325                 330                 335     


Gly Leu Gly 
            


<210>  5
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  5

Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu Pro Leu Val Leu Lys Cys 
1               5                   10                  15      


Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg Leu Glu Trp Lys Leu Asn 
            20                  25                  30          


Thr Gly Arg Thr Glu Ala Trp Lys Val Leu Ser Pro Gln Gly Gly Gly 
        35                  40                  45              


Pro Trp Asp Ser Val Ala Arg Val Leu Pro Asn Gly Ser Leu Phe Leu 
    50                  55                  60                  


Pro Ala Val Gly Ile Gln Asp Glu Gly Ile Phe Arg Cys Gln Ala Met 
65                  70                  75                  80  


Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn Tyr Arg Val Arg Val Tyr 
                85                  90                  95      


Gln Ile Pro Gly Lys Pro Glu Ile Val Asp Ser Ala Ser Glu Leu Thr 
            100                 105                 110         


Ala Gly Val Pro Asn Lys Val Gly Thr Cys Val Ser Glu Gly Ser Tyr 
        115                 120                 125             


Pro Ala Gly Thr Leu Ser Trp His Leu Asp Gly Lys Pro Leu Val Pro 
    130                 135                 140                 


Asn Glu Lys Gly Val Ser Val Lys Glu Gln Thr Arg Arg His Pro Glu 
145                 150                 155                 160 


Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu Met Val Thr Pro Ala Arg 
                165                 170                 175     


Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys Ser Phe Ser Pro Gly Leu 
            180                 185                 190         


Pro Arg His Arg Ala Leu Arg Thr Ala Pro Ile Gln Pro Arg Val Trp 
        195                 200                 205             


Glu Pro Val Pro Leu Glu Glu Val Gln Leu Val Val Glu Pro Glu Gly 
    210                 215                 220                 


Gly Ala Val Ala Pro Gly Gly Thr Val Thr Leu Thr Cys Glu Val Pro 
225                 230                 235                 240 


Ala Gln Pro Ser Pro Gln Ile His Trp Met Lys Asp Gly Val Pro Leu 
                245                 250                 255     


Pro Leu Pro Pro Ser Pro Val Leu Ile Leu Pro Glu Ile Gly Pro Gln 
            260                 265                 270         


Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr His Ser Ser His Gly Pro 
        275                 280                 285             


Gln Glu Ser Arg Ala Val Ser Ile Ser Ile Ile Glu Pro Gly Glu Glu 
    290                 295                 300                 


Gly Pro Thr Ala Gly Ser Val Gly Gly Ser Gly Leu Gly 
305                 310                 315         


<210>  6
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  6

Gln Asn Ile Thr Ala Arg Ile Gly Glu Pro Leu Val Leu Lys Cys Lys 
1               5                   10                  15      


Gly Ala Pro Lys Lys Pro Pro Gln Arg Leu Glu Trp Lys Leu Asn Thr 
            20                  25                  30          


Gly Arg Thr Glu Ala Trp Lys Val Leu Ser Pro Gln Gly Gly Gly Pro 
        35                  40                  45              


Trp Asp Ser Val Ala Arg Val Leu Pro Asn Gly Ser Leu Phe Leu Pro 
    50                  55                  60                  


Ala Val Gly Ile Gln Asp Glu Gly Ile Phe Arg Cys Gln Ala Met Asn 
65                  70                  75                  80  


Arg Asn Gly Lys Glu Thr Lys Ser Asn Tyr Arg Val Arg Val Tyr Gln 
                85                  90                  95      


Ile Pro Gly Lys Pro Glu Ile Val Asp Ser Ala Ser Glu Leu Thr Ala 
            100                 105                 110         


Gly Val Pro Asn Lys Val Gly Thr Cys Val Ser Glu Gly Ser Tyr Pro 
        115                 120                 125             


Ala Gly Thr Leu Ser Trp His Leu Asp Gly Lys Pro Leu Val Pro Asn 
    130                 135                 140                 


Glu Lys Gly Val Ser Val Lys Glu Gln Thr Arg Arg His Pro Glu Thr 
145                 150                 155                 160 


Gly Leu Phe Thr Leu Gln Ser Glu Leu Met Val Thr Pro Ala Arg Gly 
                165                 170                 175     


Gly Asp Pro Arg Pro Thr Phe Ser Cys Ser Phe Ser Pro Gly Leu Pro 
            180                 185                 190         


Arg His Arg Ala Leu Arg Thr Ala Pro Ile Gln Pro Arg Val Trp Glu 
        195                 200                 205             


Pro Val Pro Leu Glu Glu Val Gln Leu Val Val Glu Pro Glu Gly Gly 
    210                 215                 220                 


Ala Val Ala Pro Gly Gly Thr Val Thr Leu Thr Cys Glu Val Pro Ala 
225                 230                 235                 240 


Gln Pro Ser Pro Gln Ile His Trp Met Lys Asp Gly Val Pro Leu Pro 
                245                 250                 255     


Leu Pro Pro Ser Pro Val Leu Ile Leu Pro Glu Ile Gly Pro Gln Asp 
            260                 265                 270         


Gln Gly Thr Tyr Ser Cys Val Ala Thr His Ser Ser His Gly Pro Gln 
        275                 280                 285             


Glu Ser Arg Ala Val Ser Ile Ser Ile Ile Glu Pro Gly Glu Glu Gly 
    290                 295                 300                 


Pro Thr Ala Gly Ser Val Gly Gly Ser Gly Leu Gly 
305                 310                 315     


<210>  7
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  7

Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu Pro Leu Val Leu Lys Cys 
1               5                   10                  15      


Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg Leu Glu Trp Lys Leu Asn 
            20                  25                  30          


Thr Gly Arg Thr Glu Ala Trp Lys Val Leu Ser Pro Gln Gly Gly Gly 
        35                  40                  45              


Pro Trp Asp Ser Val Ala Arg Val Leu Pro Asn Gly Ser Leu Phe Leu 
    50                  55                  60                  


Pro Ala Val Gly Ile Gln Asp Glu Gly Ile Phe Arg Cys Gln Ala Met 
65                  70                  75                  80  


Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn Tyr Arg Val Arg 
                85                  90                  


<210>  8
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  8

Gln Asn Ile Thr Ala Arg Ile Gly Glu Pro Leu Val Leu Lys Cys Lys 
1               5                   10                  15      


Gly Ala Pro Lys Lys Pro Pro Gln Arg Leu Glu Trp Lys Leu Asn Thr 
            20                  25                  30          


Gly Arg Thr Glu Ala Trp Lys Val Leu Ser Pro Gln Gly Gly Gly Pro 
        35                  40                  45              


Trp Asp Ser Val Ala Arg Val Leu Pro Asn Gly Ser Leu Phe Leu Pro 
    50                  55                  60                  


Ala Val Gly Ile Gln Asp Glu Gly Ile Phe Arg Cys Gln Ala Met Asn 
65                  70                  75                  80  


Arg Asn Gly Lys Glu Thr Lys Ser Asn Tyr Arg Val Arg 
                85                  90              


<210>  9
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  9

Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu Pro Leu Val Leu Lys Cys 
1               5                   10                  15      


Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg Leu Glu Trp Lys 
            20                  25                  30  


<210>  10
<211>  29
<212>  PRT
<213>  Homo sapiens

<400>  10

Gln Asn Ile Thr Ala Arg Ile Gly Glu Pro Leu Val Leu Lys Cys Lys 
1               5                   10                  15      


Gly Ala Pro Lys Lys Pro Pro Gln Arg Leu Glu Trp Lys 
            20                  25                  


<210>  11
<211>  98
<212>  PRT
<213>  Homo sapiens

<400>  11

Pro Glu Ile Val Asp Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn 
1               5                   10                  15      


Lys Val Gly Thr Cys Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu 
            20                  25                  30          


Ser Trp His Leu Asp Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val 
        35                  40                  45              


Ser Val Lys Glu Gln Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr 
    50                  55                  60                  


Leu Gln Ser Glu Leu Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg 
65                  70                  75                  80  


Pro Thr Phe Ser Cys Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala 
                85                  90                  95      


Leu Arg 
        


<210>  12
<211>  91
<212>  PRT
<213>  Homo sapiens

<400>  12

Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu Val Val 
1               5                   10                  15      


Glu Pro Glu Gly Gly Ala Val Ala Pro Gly Gly Thr Val Thr Leu Thr 
            20                  25                  30          


Cys Glu Val Pro Ala Gln Pro Ser Pro Gln Ile His Trp Met Lys Asp 
        35                  40                  45              


Gly Val Pro Leu Pro Leu Pro Pro Ser Pro Val Leu Ile Leu Pro Glu 
    50                  55                  60                  


Ile Gly Pro Gln Asp Gln Gly Thr Tyr Ser Cys Val Ala Thr His Ser 
65                  70                  75                  80  


Ser His Gly Pro Gln Glu Ser Arg Ala Val Ser 
                85                  90      


<210>  13
<211>  101
<212>  PRT
<213>  Homo sapiens

<400>  13

Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu Pro Leu Val Leu Lys Cys 
1               5                   10                  15      


Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg Leu Glu Trp Lys Leu Asn 
            20                  25                  30          


Thr Gly Arg Thr Glu Ala Trp Lys Val Leu Ser Pro Gln Gly Gly Gly 
        35                  40                  45              


Pro Trp Asp Ser Val Ala Arg Val Leu Pro Asn Gly Ser Leu Phe Leu 
    50                  55                  60                  


Pro Ala Val Gly Ile Gln Asp Glu Gly Ile Phe Arg Cys Gln Ala Met 
65                  70                  75                  80  


Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn Tyr Arg Val Arg Val Tyr 
                85                  90                  95      


Gln Ile Pro Gly Lys 
            100     


<210>  14
<211>  100
<212>  PRT
<213>  Homo sapiens

<400>  14

Gln Asn Ile Thr Ala Arg Ile Gly Glu Pro Leu Val Leu Lys Cys Lys 
1               5                   10                  15      


Gly Ala Pro Lys Lys Pro Pro Gln Arg Leu Glu Trp Lys Leu Asn Thr 
            20                  25                  30          


Gly Arg Thr Glu Ala Trp Lys Val Leu Ser Pro Gln Gly Gly Gly Pro 
        35                  40                  45              


Trp Asp Ser Val Ala Arg Val Leu Pro Asn Gly Ser Leu Phe Leu Pro 
    50                  55                  60                  


Ala Val Gly Ile Gln Asp Glu Gly Ile Phe Arg Cys Gln Ala Met Asn 
65                  70                  75                  80  


Arg Asn Gly Lys Glu Thr Lys Ser Asn Tyr Arg Val Arg Val Tyr Gln 
                85                  90                  95      


Ile Pro Gly Lys 
            100 


<210>  15
<211>  114
<212>  PRT
<213>  Homo sapiens

<400>  15

Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu Pro Leu Val Leu Lys Cys 
1               5                   10                  15      


Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg Leu Glu Trp Lys Leu Asn 
            20                  25                  30          


Thr Gly Arg Thr Glu Ala Trp Lys Val Leu Ser Pro Gln Gly Gly Gly 
        35                  40                  45              


Pro Trp Asp Ser Val Ala Arg Val Leu Pro Asn Gly Ser Leu Phe Leu 
    50                  55                  60                  


Pro Ala Val Gly Ile Gln Asp Glu Gly Ile Phe Arg Cys Gln Ala Met 
65                  70                  75                  80  


Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn Tyr Arg Val Arg Val Tyr 
                85                  90                  95      


Gln Ile Pro Gly Lys Pro Glu Ile Val Asp Ser Ala Ser Glu Leu Thr 
            100                 105                 110         


Ala Gly 
        


<210>  16
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  16

Gln Asn Ile Thr Ala Arg Ile Gly Glu Pro Leu Val Leu Lys Cys Lys 
1               5                   10                  15      


Gly Ala Pro Lys Lys Pro Pro Gln Arg Leu Glu Trp Lys Leu Asn Thr 
            20                  25                  30          


Gly Arg Thr Glu Ala Trp Lys Val Leu Ser Pro Gln Gly Gly Gly Pro 
        35                  40                  45              


Trp Asp Ser Val Ala Arg Val Leu Pro Asn Gly Ser Leu Phe Leu Pro 
    50                  55                  60                  


Ala Val Gly Ile Gln Asp Glu Gly Ile Phe Arg Cys Gln Ala Met Asn 
65                  70                  75                  80  


Arg Asn Gly Lys Glu Thr Lys Ser Asn Tyr Arg Val Arg Val Tyr Gln 
                85                  90                  95      


Ile Pro Gly Lys Pro Glu Ile Val Asp Ser Ala Ser Glu Leu Thr Ala 
            100                 105                 110         


Gly 
    


<210>  17
<211>  204
<212>  PRT
<213>  Homo sapiens

<400>  17

Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu Pro Leu Val Leu Lys Cys 
1               5                   10                  15      


Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg Leu Glu Trp Lys Leu Asn 
            20                  25                  30          


Thr Gly Arg Thr Glu Ala Trp Lys Val Leu Ser Pro Gln Gly Gly Gly 
        35                  40                  45              


Pro Trp Asp Ser Val Ala Arg Val Leu Pro Asn Gly Ser Leu Phe Leu 
    50                  55                  60                  


Pro Ala Val Gly Ile Gln Asp Glu Gly Ile Phe Arg Cys Gln Ala Met 
65                  70                  75                  80  


Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn Tyr Arg Val Arg Val Tyr 
                85                  90                  95      


Gln Ile Pro Gly Lys Pro Glu Ile Val Asp Ser Ala Ser Glu Leu Thr 
            100                 105                 110         


Ala Gly Val Pro Asn Lys Val Gly Thr Cys Val Ser Glu Gly Ser Tyr 
        115                 120                 125             


Pro Ala Gly Thr Leu Ser Trp His Leu Asp Gly Lys Pro Leu Val Pro 
    130                 135                 140                 


Asn Glu Lys Gly Val Ser Val Lys Glu Gln Thr Arg Arg His Pro Glu 
145                 150                 155                 160 


Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu Met Val Thr Pro Ala Arg 
                165                 170                 175     


Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys Ser Phe Ser Pro Gly Leu 
            180                 185                 190         


Pro Arg His Arg Ala Leu Arg Thr Ala Pro Ile Gln 
        195                 200                 


<210>  18
<211>  203
<212>  PRT
<213>  Homo sapiens

<400>  18

Gln Asn Ile Thr Ala Arg Ile Gly Glu Pro Leu Val Leu Lys Cys Lys 
1               5                   10                  15      


Gly Ala Pro Lys Lys Pro Pro Gln Arg Leu Glu Trp Lys Leu Asn Thr 
            20                  25                  30          


Gly Arg Thr Glu Ala Trp Lys Val Leu Ser Pro Gln Gly Gly Gly Pro 
        35                  40                  45              


Trp Asp Ser Val Ala Arg Val Leu Pro Asn Gly Ser Leu Phe Leu Pro 
    50                  55                  60                  


Ala Val Gly Ile Gln Asp Glu Gly Ile Phe Arg Cys Gln Ala Met Asn 
65                  70                  75                  80  


Arg Asn Gly Lys Glu Thr Lys Ser Asn Tyr Arg Val Arg Val Tyr Gln 
                85                  90                  95      


Ile Pro Gly Lys Pro Glu Ile Val Asp Ser Ala Ser Glu Leu Thr Ala 
            100                 105                 110         


Gly Val Pro Asn Lys Val Gly Thr Cys Val Ser Glu Gly Ser Tyr Pro 
        115                 120                 125             


Ala Gly Thr Leu Ser Trp His Leu Asp Gly Lys Pro Leu Val Pro Asn 
    130                 135                 140                 


Glu Lys Gly Val Ser Val Lys Glu Gln Thr Arg Arg His Pro Glu Thr 
145                 150                 155                 160 


Gly Leu Phe Thr Leu Gln Ser Glu Leu Met Val Thr Pro Ala Arg Gly 
                165                 170                 175     


Gly Asp Pro Arg Pro Thr Phe Ser Cys Ser Phe Ser Pro Gly Leu Pro 
            180                 185                 190         


Arg His Arg Ala Leu Arg Thr Ala Pro Ile Gln 
        195                 200             


<210>  19
<211>  229
<212>  PRT
<213>  Homo sapiens

<400>  19

Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu Pro Leu Val Leu Lys Cys 
1               5                   10                  15      


Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg Leu Glu Trp Lys Leu Asn 
            20                  25                  30          


Thr Gly Arg Thr Glu Ala Trp Lys Val Leu Ser Pro Gln Gly Gly Gly 
        35                  40                  45              


Pro Trp Asp Ser Val Ala Arg Val Leu Pro Asn Gly Ser Leu Phe Leu 
    50                  55                  60                  


Pro Ala Val Gly Ile Gln Asp Glu Gly Ile Phe Arg Cys Gln Ala Met 
65                  70                  75                  80  


Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn Tyr Arg Val Arg Val Tyr 
                85                  90                  95      


Gln Ile Pro Gly Lys Pro Glu Ile Val Asp Ser Ala Ser Glu Leu Thr 
            100                 105                 110         


Ala Gly Val Pro Asn Lys Val Gly Thr Cys Val Ser Glu Gly Ser Tyr 
        115                 120                 125             


Pro Ala Gly Thr Leu Ser Trp His Leu Asp Gly Lys Pro Leu Val Pro 
    130                 135                 140                 


Asn Glu Lys Gly Val Ser Val Lys Glu Gln Thr Arg Arg His Pro Glu 
145                 150                 155                 160 


Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu Met Val Thr Pro Ala Arg 
                165                 170                 175     


Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys Ser Phe Ser Pro Gly Leu 
            180                 185                 190         


Pro Arg His Arg Ala Leu Arg Thr Ala Pro Ile Gln Pro Arg Val Trp 
        195                 200                 205             


Glu Pro Val Pro Leu Glu Glu Val Gln Leu Val Val Glu Pro Glu Gly 
    210                 215                 220                 


Gly Ala Val Ala Pro 
225                 


<210>  20
<211>  228
<212>  PRT
<213>  Homo sapiens

<400>  20

Gln Asn Ile Thr Ala Arg Ile Gly Glu Pro Leu Val Leu Lys Cys Lys 
1               5                   10                  15      


Gly Ala Pro Lys Lys Pro Pro Gln Arg Leu Glu Trp Lys Leu Asn Thr 
            20                  25                  30          


Gly Arg Thr Glu Ala Trp Lys Val Leu Ser Pro Gln Gly Gly Gly Pro 
        35                  40                  45              


Trp Asp Ser Val Ala Arg Val Leu Pro Asn Gly Ser Leu Phe Leu Pro 
    50                  55                  60                  


Ala Val Gly Ile Gln Asp Glu Gly Ile Phe Arg Cys Gln Ala Met Asn 
65                  70                  75                  80  


Arg Asn Gly Lys Glu Thr Lys Ser Asn Tyr Arg Val Arg Val Tyr Gln 
                85                  90                  95      


Ile Pro Gly Lys Pro Glu Ile Val Asp Ser Ala Ser Glu Leu Thr Ala 
            100                 105                 110         


Gly Val Pro Asn Lys Val Gly Thr Cys Val Ser Glu Gly Ser Tyr Pro 
        115                 120                 125             


Ala Gly Thr Leu Ser Trp His Leu Asp Gly Lys Pro Leu Val Pro Asn 
    130                 135                 140                 


Glu Lys Gly Val Ser Val Lys Glu Gln Thr Arg Arg His Pro Glu Thr 
145                 150                 155                 160 


Gly Leu Phe Thr Leu Gln Ser Glu Leu Met Val Thr Pro Ala Arg Gly 
                165                 170                 175     


Gly Asp Pro Arg Pro Thr Phe Ser Cys Ser Phe Ser Pro Gly Leu Pro 
            180                 185                 190         


Arg His Arg Ala Leu Arg Thr Ala Pro Ile Gln Pro Arg Val Trp Glu 
        195                 200                 205             


Pro Val Pro Leu Glu Glu Val Gln Leu Val Val Glu Pro Glu Gly Gly 
    210                 215                 220                 


Ala Val Ala Pro 
225             


<210>  21
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  21

Val Tyr Gln Ile Pro Gly Lys 
1               5           


<210>  22
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  22

Thr Ala Pro Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu 
1               5                   10                  15      


Val Gln Leu Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro 
            20                  25                  30  


<210>  23
<211>  20
<212>  PRT
<213>  Homo sapiens

<400>  23

Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp Ser Ala Ser Glu 
1               5                   10                  15      


Leu Thr Ala Gly 
            20  


<210>  24
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  24

Thr Ala Pro Ile Gln 
1               5   


<210>  25
<211>  354
<212>  DNA
<213>  Homo sapiens

<400>  25
atggcagccg gaacagcagt tggagcctgg gtgctggtcc tcagtctgtg gggggcagta       60

gtaggtgctc aaaacatcac agcccggatt ggcgagccac tggtgctgaa gtgtaagggg      120

gcccccaaga aaccacccca gcggctggaa tggaaactga acacaggccg gacagaagct      180

tggaaggtcc tgtctcccca gggaggaggc ccctgggaca gtgtggctcg tgtccttccc      240

aacggctccc tcttccttcc ggctgtcggg atccaggatg aggggatttt ccggtgccag      300

gcaatgaaca ggaatggaaa ggagaccaag tccaactacc gagtccgtgt ctac            354


<210>  26
<211>  369
<212>  DNA
<213>  Homo sapiens

<400>  26
atggcagccg gaacagcagt tggagcctgg gtgctggtcc tcagtctgtg gggggcagta       60

gtaggtgctc aaaacatcac agcccggatt ggcgagccac tggtgctgaa gtgtaagggg      120

gcccccaaga aaccacccca gcggctggaa tggaaactga acacaggccg gacagaagct      180

tggaaggtcc tgtctcccca gggaggaggc ccctgggaca gtgtggctcg tgtccttccc      240

aacggctccc tcttccttcc ggctgtcggg atccaggatg aggggatttt ccggtgccag      300

gcaatgaaca ggaatggaaa ggagaccaag tccaactacc gagtccgtgt ctaccagatt      360

cctgggaag                                                              369


<210>  27
<211>  408
<212>  DNA
<213>  Homo sapiens

<400>  27
atggcagccg gaacagcagt tggagcctgg gtgctggtcc tcagtctgtg gggggcagta       60

gtaggtgctc aaaacatcac agcccggatt ggcgagccac tggtgctgaa gtgtaagggg      120

gcccccaaga aaccacccca gcggctggaa tggaaactga acacaggccg gacagaagct      180

tggaaggtcc tgtctcccca gggaggaggc ccctgggaca gtgtggctcg tgtccttccc      240

aacggctccc tcttccttcc ggctgtcggg atccaggatg aggggatttt ccggtgccag      300

gcaatgaaca ggaatggaaa ggagaccaag tccaactacc gagtccgtgt ctaccagatt      360

cctgggaagc cagaaattgt agattctgcc tctgaactca cggctggt                   408


<210>  28
<211>  690
<212>  DNA
<213>  Homo sapiens

<400>  28
atggcagccg gaacagcagt tggagcctgg gcgctggtcc tcagtctgtg gggggcagta       60

gtaggtgctc aaaacatcac agcccggatt ggcgagccac tggtgctgaa gtgtaagggg      120

gcccccaaga aaccacccca gcggctggaa tggaaactga acacaggccg gacagaagct      180

tggaaggtcc tgtctcccca gggaggaggc ccctgggaca gtgtggctcg tgtccttccc      240

aacggctccc tcttccttcc ggctgtcggg atccaggatg aggggatttt ccggtgccag      300

gcaatgaaca ggaatggaaa ggagaccaag tccaactacc gagtccgtgt ctaccagatt      360

cctgggaagc cagaaattgt agattctgcc tctgaactca cggctggtgt tcccaataag      420

gtggggacat gtgtgtcaga ggggagctac cctgcaggga ctcttagctg gcacttggat      480

gggaagcccc tggtgcctaa tgagaaggga gtatctgtga aggaacagac caggagacac      540

cctgagacag ggctcttcac actgcagtcg gagctaatgg tgaccccagc ccggggagga      600

gatccccgtc ccaccttctc ctgtagcttc agcccaggcc ttccccgaca ccgggccttg      660

cgcacagccc ccatccagcc ccgtgtctgg                                       690


<210>  29
<211>  753
<212>  DNA
<213>  Homo sapiens

<400>  29
atggcagccg gaacagcagt tggagcctgg gcgctggtcc tcagtctgtg gggggcagta       60

gtaggtgctc aaaacatcac agcccggatt ggcgagccac tggtgctgaa gtgtaagggg      120

gcccccaaga aaccacccca gcggctggaa tggaaactga acacaggccg gacagaagct      180

tggaaggtcc tgtctcccca gggaggaggc ccctgggaca gtgtggctcg tgtccttccc      240

aacggctccc tcttccttcc ggctgtcggg atccaggatg aggggatttt ccggtgccag      300

gcaatgaaca ggaatggaaa ggagaccaag tccaactacc gagtccgtgt ctaccagatt      360

cctgggaagc cagaaattgt agattctgcc tctgaactca cggctggtgt tcccaataag      420

gtggggacat gtgtgtcaga ggggagctac cctgcaggga ctcttagctg gcacttggat      480

gggaagcccc tggtgcctaa tgagaaggga gtatctgtga aggaacagac caggagacac      540

cctgagacag ggctcttcac actgcagtcg gagctaatgg tgaccccagc ccggggagga      600

gatccccgtc ccaccttctc ctgtagcttc agcccaggcc ttccccgaca ccgggccttg      660

cgcacagccc ccatccagcc ccgtgtctgg gagcctgtgc ctctggagga ggtccaattg      720

gtggtggagc cagaaggtgg agcagtagct cct                                   753


<210>  30
<211>  1386
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial = synthetic construct

<400>  30
atggcagccg gaacagcagt tggagcctgg gcgctggtcc tcagtctgtg gggggcagta       60

gtaggtgctc aaaacatcac agcccggatt ggcgagccac tggtgctgaa gtgtaagggg      120

gcccccaaga aaccacccca gcggctggaa tggaaactga acacaggccg gacagaagct      180

tggaaggtcc tgtctcccca gggaggaggc ccctgggaca gtgtggctcg tgtccttccc      240

aacggctccc tcttccttcc ggctgtcggg atccaggatg aggggatttt ccggtgccag      300

gcaatgaaca ggaatggaaa ggagaccaag tccaactacc gagtccgtgt ctaccagatt      360

cctgggaagc cagaaattgt agattctgcc tctgaactca cggctggtgt tcccaataag      420

gtggggacat gtgtgtcaga ggggagctac cctgcaggga ctcttagctg gcacttggat      480

gggaagcccc tggtgcctaa tgagaaggga gtatctgtga aggaacagac caggagacac      540

cctgagacag ggctcttcac actgcagtcg gagctaatgg tgaccccagc ccggggagga      600

gatccccgtc ccaccttctc ctgtagcttc agcccaggcc ttccccgaca ccgggccttg      660

cgcacagccc ccatccagcc ccgtgtctgg gagcctgtgc ctctggagga ggtccaattg      720

gtggtggagc cagaaggtgg agcagtagct cctccgtcag tcttcctctt ccccccaaaa      780

cccaaggaca ccctcatgat ctcccggacc cctgaggtca catgcgtggt ggtggacgtg      840

agccacgaag accctgaggt caagttcaac tggtacgtgg acggcgtgga ggtgcataat      900

gccaagacaa agccgcggga ggagcagtac aacagcacgt accgtgtggt cagcgtcctc      960

accgtcctgc accaggactg gctgaatggc aaggagtaca agtgcaaggt ctccaacaaa     1020

gccctcccag cccccatcga gaaaaccatc tccaaagcca aagggcagcc ccgagaacca     1080

caggtgtaca ccctgccccc atcccgggat gagctgacca agaaccaggt cagcctgacc     1140

tgcctggtca aaggcttcta tcccagcgac atcgccgtgg agtgggagag caatgggcag     1200

ccggagaaca actacaagac cacgcctccc gtgctggact ccgacggctc cttcttcctc     1260

tacagcaagc tcaccgtgga caagagcagg tggcagcagg ggaacgtctt ctcatgctcc     1320

gtgatgcatg aggctctgca caaccactac acgcagaaga gcctctccct gtctccgggt     1380

aaatga                                                                1386


<210>  31
<211>  1041
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Artificial = synthetic construct

<400>  31
atggcagccg gaacagcagt tggagcctgg gtgctggtcc tcagtctgtg gggggcagta       60

gtaggtgctc aaaacatcac agcccggatt ggcgagccac tggtgctgaa gtgtaagggg      120

gcccccaaga aaccacccca gcggctggaa tggaaactga acacaggccg gacagaagct      180

tggaaggtcc tgtctcccca gggaggaggc ccctgggaca gtgtggctcg tgtccttccc      240

aacggctccc tcttccttcc ggctgtcggg atccaggatg aggggatttt ccggtgccag      300

gcaatgaaca ggaatggaaa ggagaccaag tccaactacc gagtccgtgt ctaccagatt      360

cctgggaagc cagaaattgt agattctgcc tctgaactca cggctggtcc gtcagtcttc      420

ctcttccccc caaaacccaa ggacaccctc atgatctccc ggacccctga ggtcacatgc      480

gtggtggtgg acgtgagcca cgaagaccct gaggtcaagt tcaactggta cgtggacggc      540

gtggaggtgc ataatgccaa gacaaagccg cgggaggagc agtacaacag cacgtaccgt      600

gtggtcagcg tcctcaccgt cctgcaccag gactggctga atggcaagga gtacaagtgc      660

aaggtctcca acaaagccct cccagccccc atcgagaaaa ccatctccaa agccaaaggg      720

cagccccgag aaccacaggt gtacaccctg cccccatccc gggatgagct gaccaagaac      780

caggtcagcc tgacctgcct ggtcaaaggc ttctatccca gcgacatcgc cgtggagtgg      840

gagagcaatg ggcagccgga gaacaactac aagaccacgc ctcccgtgct ggactccgac      900

ggctccttct tcctctacag caagctcacc gtggacaaga gcaggtggca gcaggggaac      960

gtcttctcat gctccgtgat gcatgaggct ctgcacaacc actacacgca gaagagcctc     1020

tccctgtctc cgggtaaatg a                                               1041


<210>  32
<211>  461
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial = synthetic construct

<400>  32

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Ala Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Thr Ala Gly Val Pro Asn Lys Val Gly Thr Cys 
    130                 135                 140                 


Val Ser Glu Gly Ser Tyr Pro Ala Gly Thr Leu Ser Trp His Leu Asp 
145                 150                 155                 160 


Gly Lys Pro Leu Val Pro Asn Glu Lys Gly Val Ser Val Lys Glu Gln 
                165                 170                 175     


Thr Arg Arg His Pro Glu Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu 
            180                 185                 190         


Met Val Thr Pro Ala Arg Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys 
        195                 200                 205             


Ser Phe Ser Pro Gly Leu Pro Arg His Arg Ala Leu Arg Thr Ala Pro 
    210                 215                 220                 


Ile Gln Pro Arg Val Trp Glu Pro Val Pro Leu Glu Glu Val Gln Leu 
225                 230                 235                 240 


Val Val Glu Pro Glu Gly Gly Ala Val Ala Pro Pro Ser Val Phe Leu 
                245                 250                 255     


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
            260                 265                 270         


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
        275                 280                 285             


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
    290                 295                 300                 


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
305                 310                 315                 320 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
                325                 330                 335     


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
            340                 345                 350         


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
        355                 360                 365             


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
    370                 375                 380                 


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
385                 390                 395                 400 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
                405                 410                 415     


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
            420                 425                 430         


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
        435                 440                 445             


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460     


<210>  33
<211>  439
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial = synthetic construct

<400>  33

Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu Pro Leu Val Leu Lys Cys 
1               5                   10                  15      


Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg Leu Glu Trp Lys Leu Asn 
            20                  25                  30          


Thr Gly Arg Thr Glu Ala Trp Lys Val Leu Ser Pro Gln Gly Gly Gly 
        35                  40                  45              


Pro Trp Asp Ser Val Ala Arg Val Leu Pro Asn Gly Ser Leu Phe Leu 
    50                  55                  60                  


Pro Ala Val Gly Ile Gln Asp Glu Gly Ile Phe Arg Cys Gln Ala Met 
65                  70                  75                  80  


Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn Tyr Arg Val Arg Val Tyr 
                85                  90                  95      


Gln Ile Pro Gly Lys Pro Glu Ile Val Asp Ser Ala Ser Glu Leu Thr 
            100                 105                 110         


Ala Gly Val Pro Asn Lys Val Gly Thr Cys Val Ser Glu Gly Ser Tyr 
        115                 120                 125             


Pro Ala Gly Thr Leu Ser Trp His Leu Asp Gly Lys Pro Leu Val Pro 
    130                 135                 140                 


Asn Glu Lys Gly Val Ser Val Lys Glu Gln Thr Arg Arg His Pro Glu 
145                 150                 155                 160 


Thr Gly Leu Phe Thr Leu Gln Ser Glu Leu Met Val Thr Pro Ala Arg 
                165                 170                 175     


Gly Gly Asp Pro Arg Pro Thr Phe Ser Cys Ser Phe Ser Pro Gly Leu 
            180                 185                 190         


Pro Arg His Arg Ala Leu Arg Thr Ala Pro Ile Gln Pro Arg Val Trp 
        195                 200                 205             


Glu Pro Val Pro Leu Glu Glu Val Gln Leu Val Val Glu Pro Glu Gly 
    210                 215                 220                 


Gly Ala Val Ala Pro Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
225                 230                 235                 240 


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
                245                 250                 255     


Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp 
            260                 265                 270         


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr 
        275                 280                 285             


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
    290                 295                 300                 


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu 
305                 310                 315                 320 


Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
                325                 330                 335     


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys 
            340                 345                 350         


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
        355                 360                 365             


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
    370                 375                 380                 


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
385                 390                 395                 400 


Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser 
                405                 410                 415     


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
            420                 425                 430         


Leu Ser Leu Ser Pro Gly Lys 
        435                 


<210>  34
<211>  438
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial = synthetic construct

<400>  34

Gln Asn Ile Thr Ala Arg Ile Gly Glu Pro Leu Val Leu Lys Cys Lys 
1               5                   10                  15      


Gly Ala Pro Lys Lys Pro Pro Gln Arg Leu Glu Trp Lys Leu Asn Thr 
            20                  25                  30          


Gly Arg Thr Glu Ala Trp Lys Val Leu Ser Pro Gln Gly Gly Gly Pro 
        35                  40                  45              


Trp Asp Ser Val Ala Arg Val Leu Pro Asn Gly Ser Leu Phe Leu Pro 
    50                  55                  60                  


Ala Val Gly Ile Gln Asp Glu Gly Ile Phe Arg Cys Gln Ala Met Asn 
65                  70                  75                  80  


Arg Asn Gly Lys Glu Thr Lys Ser Asn Tyr Arg Val Arg Val Tyr Gln 
                85                  90                  95      


Ile Pro Gly Lys Pro Glu Ile Val Asp Ser Ala Ser Glu Leu Thr Ala 
            100                 105                 110         


Gly Val Pro Asn Lys Val Gly Thr Cys Val Ser Glu Gly Ser Tyr Pro 
        115                 120                 125             


Ala Gly Thr Leu Ser Trp His Leu Asp Gly Lys Pro Leu Val Pro Asn 
    130                 135                 140                 


Glu Lys Gly Val Ser Val Lys Glu Gln Thr Arg Arg His Pro Glu Thr 
145                 150                 155                 160 


Gly Leu Phe Thr Leu Gln Ser Glu Leu Met Val Thr Pro Ala Arg Gly 
                165                 170                 175     


Gly Asp Pro Arg Pro Thr Phe Ser Cys Ser Phe Ser Pro Gly Leu Pro 
            180                 185                 190         


Arg His Arg Ala Leu Arg Thr Ala Pro Ile Gln Pro Arg Val Trp Glu 
        195                 200                 205             


Pro Val Pro Leu Glu Glu Val Gln Leu Val Val Glu Pro Glu Gly Gly 
    210                 215                 220                 


Ala Val Ala Pro Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
225                 230                 235                 240 


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
                245                 250                 255     


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
            260                 265                 270         


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
        275                 280                 285             


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
    290                 295                 300                 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
305                 310                 315                 320 


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
                325                 330                 335     


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
            340                 345                 350         


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
        355                 360                 365             


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
    370                 375                 380                 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
385                 390                 395                 400 


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
                405                 410                 415     


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
            420                 425                 430         


Ser Leu Ser Pro Gly Lys 
        435             


<210>  35
<211>  346
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial = synthetic construct

<400>  35

Met Ala Ala Gly Thr Ala Val Gly Ala Trp Val Leu Val Leu Ser Leu 
1               5                   10                  15      


Trp Gly Ala Val Val Gly Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu 
            20                  25                  30          


Pro Leu Val Leu Lys Cys Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg 
        35                  40                  45              


Leu Glu Trp Lys Leu Asn Thr Gly Arg Thr Glu Ala Trp Lys Val Leu 
    50                  55                  60                  


Ser Pro Gln Gly Gly Gly Pro Trp Asp Ser Val Ala Arg Val Leu Pro 
65                  70                  75                  80  


Asn Gly Ser Leu Phe Leu Pro Ala Val Gly Ile Gln Asp Glu Gly Ile 
                85                  90                  95      


Phe Arg Cys Gln Ala Met Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn 
            100                 105                 110         


Tyr Arg Val Arg Val Tyr Gln Ile Pro Gly Lys Pro Glu Ile Val Asp 
        115                 120                 125             


Ser Ala Ser Glu Leu Thr Ala Gly Pro Ser Val Phe Leu Phe Pro Pro 
    130                 135                 140                 


Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys 
145                 150                 155                 160 


Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp 
                165                 170                 175     


Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu 
            180                 185                 190         


Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu 
        195                 200                 205             


His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn 
    210                 215                 220                 


Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly 
225                 230                 235                 240 


Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu 
                245                 250                 255     


Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr 
            260                 265                 270         


Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn 
        275                 280                 285             


Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe 
    290                 295                 300                 


Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn 
305                 310                 315                 320 


Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr 
                325                 330                 335     


Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            340                 345     


<210>  36
<211>  324
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial = synthetic construct

<400>  36

Ala Gln Asn Ile Thr Ala Arg Ile Gly Glu Pro Leu Val Leu Lys Cys 
1               5                   10                  15      


Lys Gly Ala Pro Lys Lys Pro Pro Gln Arg Leu Glu Trp Lys Leu Asn 
            20                  25                  30          


Thr Gly Arg Thr Glu Ala Trp Lys Val Leu Ser Pro Gln Gly Gly Gly 
        35                  40                  45              


Pro Trp Asp Ser Val Ala Arg Val Leu Pro Asn Gly Ser Leu Phe Leu 
    50                  55                  60                  


Pro Ala Val Gly Ile Gln Asp Glu Gly Ile Phe Arg Cys Gln Ala Met 
65                  70                  75                  80  


Asn Arg Asn Gly Lys Glu Thr Lys Ser Asn Tyr Arg Val Arg Val Tyr 
                85                  90                  95      


Gln Ile Pro Gly Lys Pro Glu Ile Val Asp Ser Ala Ser Glu Leu Thr 
            100                 105                 110         


Ala Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        115                 120                 125             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    130                 135                 140                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
145                 150                 155                 160 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                165                 170                 175     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            180                 185                 190         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
        195                 200                 205             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    210                 215                 220                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
225                 230                 235                 240 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                245                 250                 255     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            260                 265                 270         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        275                 280                 285             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    290                 295                 300                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
305                 310                 315                 320 


Ser Pro Gly Lys 
                


<210>  37
<211>  323
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Artificial = synthetic construct

<400>  37

Gln Asn Ile Thr Ala Arg Ile Gly Glu Pro Leu Val Leu Lys Cys Lys 
1               5                   10                  15      


Gly Ala Pro Lys Lys Pro Pro Gln Arg Leu Glu Trp Lys Leu Asn Thr 
            20                  25                  30          


Gly Arg Thr Glu Ala Trp Lys Val Leu Ser Pro Gln Gly Gly Gly Pro 
        35                  40                  45              


Trp Asp Ser Val Ala Arg Val Leu Pro Asn Gly Ser Leu Phe Leu Pro 
    50                  55                  60                  


Ala Val Gly Ile Gln Asp Glu Gly Ile Phe Arg Cys Gln Ala Met Asn 
65                  70                  75                  80  


Arg Asn Gly Lys Glu Thr Lys Ser Asn Tyr Arg Val Arg Val Tyr Gln 
                85                  90                  95      


Ile Pro Gly Lys Pro Glu Ile Val Asp Ser Ala Ser Glu Leu Thr Ala 
            100                 105                 110         


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
        115                 120                 125             


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
    130                 135                 140                 


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
145                 150                 155                 160 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
                165                 170                 175     


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
            180                 185                 190         


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
        195                 200                 205             


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
    210                 215                 220                 


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
225                 230                 235                 240 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
                245                 250                 255     


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
            260                 265                 270         


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
        275                 280                 285             


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
    290                 295                 300                 


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
305                 310                 315                 320 


Pro Gly Lys 
            


<210>  38
<211>  210
<212>  PRT
<213>  Homo sapiens

<400>  38

Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
1               5                   10                  15      


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            20                  25                  30          


Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        35                  40                  45              


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg 
    50                  55                  60                  


Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys 
65                  70                  75                  80  


Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu 
                85                  90                  95      


Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            100                 105                 110         


Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu 
        115                 120                 125             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    130                 135                 140                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val 
145                 150                 155                 160 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                165                 170                 175     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            180                 185                 190         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        195                 200                 205             


Gly Lys 
    210 


<210>  39
<211>  633
<212>  DNA
<213>  Homo sapiens

<400>  39
ccgtcagtct tcctcttccc cccaaaaccc aaggacaccc tcatgatctc ccggacccct       60

gaggtcacat gcgtggtggt ggacgtgagc cacgaagacc ctgaggtcaa gttcaactgg      120

tacgtggacg gcgtggaggt gcataatgcc aagacaaagc cgcgggagga gcagtacaac      180

agcacgtacc gtgtggtcag cgtcctcacc gtcctgcacc aggactggct gaatggcaag      240

gagtacaagt gcaaggtctc caacaaagcc ctcccagccc ccatcgagaa aaccatctcc      300

aaagccaaag ggcagccccg agaaccacag gtgtacaccc tgcccccatc ccgggatgag      360

ctgaccaaga accaggtcag cctgacctgc ctggtcaaag gcttctatcc cagcgacatc      420

gccgtggagt gggagagcaa tgggcagccg gagaacaact acaagaccac gcctcccgtg      480

ctggactccg acggctcctt cttcctctac agcaagctca ccgtggacaa gagcaggtgg      540

cagcagggga acgtcttctc atgctccgtg atgcatgagg ctctgcacaa ccactacacg      600

cagaagagcc tctccctgtc tccgggtaaa tga                                   633


<210>  40
<211>  220
<212>  PRT
<213>  Homo sapiens

<400>  40

Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
1               5                   10                  15      


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            20                  25                  30          


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        35                  40                  45              


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    50                  55                  60                  


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
65                  70                  75                  80  


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                85                  90                  95      


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            100                 105                 110         


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
        115                 120                 125             


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
    130                 135                 140                 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
145                 150                 155                 160 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
                165                 170                 175     


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
            180                 185                 190         


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
        195                 200                 205             


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    210                 215                 220 


<210>  41
<211>  663
<212>  DNA
<213>  Homo sapiens

<400>  41
ccgtgcccag cacctgaact cctgggggga ccgtcagtct tcctcttccc cccaaaaccc       60

aaggacaccc tcatgatctc ccggacccct gaggtcacat gcgtggtggt ggacgtgagc      120

cacgaagacc ctgaggtcaa gttcaactgg tacgtggacg gcgtggaggt gcataatgcc      180

aagacaaagc cgcgggagga gcagtacaac agcacgtacc gtgtggtcag cgtcctcacc      240

gtcctgcacc aggactggct gaatggcaag gagtacaagt gcaaggtctc caacaaagcc      300

ctcccagccc ccatcgagaa aaccatctcc aaagccaaag ggcagccccg agaaccacag      360

gtgtacaccc tgcccccatc ccgggatgag ctgaccaaga accaggtcag cctgacctgc      420

ctggtcaaag gcttctatcc cagcgacatc gccgtggagt gggagagcaa tgggcagccg      480

gagaacaact acaagaccac gcctcccgtg ctggactccg acggctcctt cttcctctac      540

agcaagctca ccgtggacaa gagcaggtgg cagcagggga acgtcttctc atgctccgtg      600

atgcatgagg ctctgcacaa ccactacacg cagaagagcc tctccctgtc tccgggtaaa      660

tga                                                                    663


<210>  42
<211>  113
<212>  PRT
<213>  Homo sapiens

<400>  42

Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
1               5                   10                  15      


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
            20                  25                  30          


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
        35                  40                  45              


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
    50                  55                  60                  


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
65                  70                  75                  80  


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
                85                  90                  95      


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
            100                 105                 110         


Lys 
    


<210>  43
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  43

Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp 
1               5                   10                  15      


Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
            20                  25                  30          


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
        35                  40                  45              


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
    50                  55                  60                  


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
65                  70                  75                  80  


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
                85                  90                  95      


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
            100                 105         


<210>  44
<211>  25
<212>  PRT
<213>  Homo sapiens

<400>  44

Ile Ser Ile Ile Glu Pro Gly Glu Glu Gly Pro Thr Ala Gly Ser Val 
1               5                   10                  15      


Gly Gly Ser Gly Leu Gly Thr Leu Ala 
            20                  25  


