                         SEQUENCE LISTING

<110>  THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE 
       SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
 
<120>  HUMAN DOMAIN ANTIBODIES AGAINST COMPONENTS OF THE HUMAN 
       INSULIN-LIKE GROWTH FACTOR (IGF) SYSTEM

<130>  706831

<150>  US 61/249,476
<151>  2009-10-07

<160>  28    

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  1

Gln Gln Tyr Lys Thr Tyr Pro Leu Thr Phe 
1               5                   10  


<210>  2
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  2

Ile Ser Gly Ser Gly Gly Thr Thr 
1               5               


<210>  3
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  3

Ala Arg Val Ala Ser Arg Asp Tyr Phe Asp Tyr 
1               5                   10      


<210>  4
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  4

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Asp Tyr Ser Gln Gln Tyr Lys 
            20                  25                  30          


Thr Tyr Pro Leu Thr Phe Met Ser Trp Val Arg Gln Ala Pro Gly Gln 
        35                  40                  45              


Arg Leu Glu Trp Val Ala Gly Ile Ser Gly Ser Gly Gly Thr Thr Val 
    50                  55                  60                  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
65                  70                  75                  80  


Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr 
                85                  90                  95      


Ala Met Tyr Tyr Cys Ala Arg Val Ala Ser Arg Asp Tyr Phe Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  5
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  5

Leu Gln His Asp Asn Phe Pro Tyr Thr Phe 
1               5                   10  


<210>  6
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  6

Ile Ser Gly Ser Gly Gly Ser Thr 
1               5               


<210>  7
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  7

Ala Arg Ile Arg Trp Leu Gln Asp Leu Asp Tyr 
1               5                   10      


<210>  8
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  8

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Tyr Tyr Ser Leu Gln His Asp 
            20                  25                  30          


Asn Phe Pro Tyr Thr Phe Met Ser Trp Val Arg Gln Ala Pro Gly Gln 
        35                  40                  45              


Arg Leu Glu Trp Val Ser Gly Ile Ser Gly Ser Gly Gly Ser Thr Tyr 
    50                  55                  60                  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
65                  70                  75                  80  


Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr 
                85                  90                  95      


Ala Met Tyr Tyr Cys Ala Arg Ile Arg Trp Leu Gln Asp Leu Asp Tyr 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  9
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  9

Gln Gln Tyr Asn Ser Tyr Pro Ile Thr Phe 
1               5                   10  


<210>  10
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  10

Ile Asn Gln Asp Gly Ser Gln Ile 
1               5               


<210>  11
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  11

Ala Val Asp Leu Arg Ser Gly Ala Arg Asn Phe Gln His 
1               5                   10              


<210>  12
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  12

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Tyr Tyr Ser Gln Gln Tyr Asn 
            20                  25                  30          


Ser Tyr Pro Ile Thr Phe Met Ser Trp Val Arg Gln Ala Pro Gly Gln 
        35                  40                  45              


Arg Leu Glu Trp Val Ala Ser Ile Asn Gln Asp Gly Ser Gln Ile Asp 
    50                  55                  60                  


Tyr Ala Gly Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
65                  70                  75                  80  


Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr 
                85                  90                  95      


Ala Thr Tyr Tyr Cys Ala Val Asp Leu Arg Ser Gly Ala Arg Asn Phe 
            100                 105                 110         


Gln His Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 125 


<210>  13
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  13

Asp Phe Tyr Phe Tyr Asp Tyr Glu 
1               5               


<210>  14
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  14

Ile Ser His Gly Gly Ile Thr 
1               5           


<210>  15
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  15

Ala Arg Asp Tyr Gly Tyr Ala Phe Asp Ile 
1               5                   10  


<210>  16
<211>  116
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  16

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Asp Phe Tyr Phe Tyr Asp Tyr 
            20                  25                  30          


Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ser Ile Ser His Gly Gly Ile Thr His Tyr Thr Tyr Ser Leu Lys 
    50                  55                  60                  


Ser Arg Val Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Asp Tyr Gly Tyr Ala Phe Asp Ile Trp Gly Gln Trp Thr Thr Gly 
            100                 105                 110         


Thr Val Ser Ser 
        115     


<210>  17
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  17

Ser Phe Ser Phe Ser Asp Tyr Glu 
1               5               


<210>  18
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  18

Ile Asn Ser Asp Gly Val Ile 
1               5           


<210>  19
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  19

Val Arg Val Ala Val Pro Gly Lys Arg Tyr Phe Gln Tyr 
1               5                   10              


<210>  20
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  20

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Ser Phe Ser Phe Ser Asp Tyr 
            20                  25                  30          


Glu Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala His Ile Asn Ser Asp Gly Val Ile Gln Tyr Ala Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Thr Leu Arg Ala Glu Asp Thr Ala Thr Tyr Tyr Cys Val 
                85                  90                  95      


Arg Val Ala Val Pro Gly Lys Arg Tyr Phe Gln Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  21
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  21

Gln Ser Phe Asp Ser Asp Ser Val Val Phe 
1               5                   10  


<210>  22
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  22

Met Ser Asn Thr Gly Thr Tyr Ile 
1               5               


<210>  23
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  23

Val Lys Glu Trp Asp Arg Gly Leu Arg Arg Leu Gln His 
1               5                   10              


<210>  24
<211>  125
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  24

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Tyr Tyr Gly Gln Ser Phe Asp 
            20                  25                  30          


Ser Asp Ser Val Val Phe Met Ser Trp Val Arg Gln Ala Pro Gly Lys 
        35                  40                  45              


Gly Leu Glu Trp Ile Ser Ser Met Ser Asn Thr Gly Thr Tyr Ile Asp 
    50                  55                  60                  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
65                  70                  75                  80  


Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr 
                85                  90                  95      


Ala Thr Tyr Tyr Cys Val Lys Glu Trp Asp Arg Gly Leu Arg Arg Leu 
            100                 105                 110         


Gln His Trp Gly Gln Gly Thr Val Val Thr Val Ser Ser 
        115                 120                 125 


<210>  25
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  25

Gln Gln Thr Tyr Ser Ala Pro Ile Thr Phe 
1               5                   10  


<210>  26
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  26

Thr Ser Trp Asn Gly Gly Thr Thr 
1               5               


<210>  27
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  27

Val Thr Asp Thr Ser Gly Trp Arg Tyr Phe Gln Asp 
1               5                   10          


<210>  28
<211>  124
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic

<400>  28

Gln Val Gln Leu Val Gln Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Asn Tyr Ser Gln Gln Thr Tyr 
            20                  25                  30          


Ser Ala Pro Ile Thr Phe Met Ser Trp Val Arg Gln Ala Pro Gly Gln 
        35                  40                  45              


Gly Leu Glu Trp Val Ser Ser Thr Ser Trp Asn Gly Gly Thr Thr Asp 
    50                  55                  60                  


Tyr Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 
65                  70                  75                  80  


Lys Asn Thr Leu Tyr Leu Gln Met Asn Thr Leu Arg Ala Glu Asp Thr 
                85                  90                  95      


Ala Met Tyr Tyr Cys Val Thr Asp Thr Ser Gly Trp Arg Tyr Phe Gln 
            100                 105                 110         


Asp Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


