                         SEQUENCE LISTING

<110>  INSTITUT DE MYOLOGIE
       CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
       INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE 
       (INSERM)
       UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6)
 
<120>  NUCLEIC ACID MOLECULES AND METHODS FOR EXCHANGING EXON(S) BY  
       TRANSSPLICING

<130>  D27736

<150>  US 61/249,702
<151>  2009-10-08

<160>  73    

<170>  PatentIn version 3.3

<210>  1
<211>  537
<212>  DNA
<213>  artificial

<220>
<223>  Nucleotide sequence of the Pre-Trans-Splicing molecule protein, 
       exon 24

<400>  1
atatattttc agatttaaaa agaataagta tacaacatgg gatttttaga atcaacaaaa     60

aaattagtct ttatatgtcc tcacatcaca gaagtttctc ttactagtat ttaatttcca    120

gacttaggct attaaaataa ctactcaata ctcgagagat ctccgcggaa cattattata    180

acgttgctcg aatactaact gatatctctt cttttttttt ttccggaaaa cagaatcaca    240

taaaaacctt acagaaatgg atggctgaag ttgatgtttt cctgaaagag gaatggcctg    300

ccctggggga tgctgaaatc ctgaaaaaac agctcaaaca atgcagagta agaacagctc    360

tttctttcca tgggttggcc tgaattctta gttccatgta attcacaaaa tcaagttata    420

attgtcttct tttctaaaat ttatattgaa aatacatgca tcacagaaaa tttccctttc    480

aatatgatta aaatgtggtt aataactaca gatttaaaaa caattgacta aatataa       537


<210>  2
<211>  636
<212>  DNA
<213>  artificial

<220>
<223>  Nucleotide sequence of the Pre-Trans-Splicing molecule protein, 
       exon 23

<400>  2
atatattttc agatttaaaa agaataagta tacaacatgg gatttttaga atcaacaaaa     60

aaattagtct ttatatgtcc tcacatcaca gaagtttctc ttactagtat ttaatttcca    120

gacttaggct attaaaataa ctactcaata ctcgagagat ctccgcggaa cattattata    180

acgttgctcg aatactaact gatatctctt cttttttttt ttccggaaaa caggctctgc    240

aaagttcttt gaaagagcaa caaaatggct tcaactatct gagtgacact gtgaaggaga    300

tggccaagaa agcaccttca gaaatatgcc agaaatatct gtcagaattt gaagagattg    360

aggggcactg gaagaaactt tcctcccagt tggtggaaag ctgccaaaag ctagaagaac    420

atatgaataa gcttcgaaaa tttcaggtaa gaacagctct ttctttccat gggttggcct    480

gaattcttag ttccatgtaa ttcacaaaat caagttataa ttgtcttctt ttctaaaatt    540

tatattgaaa atacatgcat cacagaaaat ttccctttca atatgattaa aatgtggtta    600

ataactacag atttaaaaac aattgactaa atataa                              636


<210>  3
<211>  71
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Protein sequence of the murine dystrophin gene DMD, exon 23

<400>  3

Ala Leu Gln Ser Ser Leu Lys Glu Gln Gln Asn Gly Phe Asn Tyr Leu 
1               5                   10                  15      

Ser Asp Thr Val Lys Glu Met Ala Lys Lys Ala Pro Ser Glu Ile Cys 
            20                  25                  30          

Gln Lys Tyr Leu Ser Glu Phe Glu Glu Ile Glu Gly His Trp Lys Lys 
        35                  40                  45              

Leu Ser Ser Gln Leu Val Glu Ser Cys Gln Lys Leu Glu Glu His Met 
    50                  55                  60                  

Asn Lys Leu Arg Lys Phe Gln 
65                  70      


<210>  4
<211>  38
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Protein sequence of the murine dystrophin gene DMD, exon 24

<400>  4

Asn His Ile Lys Thr Leu Gln Lys Trp Met Ala Glu Val Asp Val Phe 
1               5                   10                  15      

Leu Lys Glu Glu Trp Pro Ala Leu Gly Asp Ala Glu Ile Leu Lys Lys 
            20                  25                  30          

Gln Leu Lys Gln Cys Arg 
        35              


<210>  5
<211>  3678
<212>  PRT
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Protein sequence of the murine dystrophin gene DMD

<400>  5

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      

Gln Lys Lys Thr Phe Thr Lys Trp Ile Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          

Gly Lys Gln His Ile Asp Asn Leu Phe Ser Asp Leu Gln Asp Gly Lys 
        35                  40                  45              

Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  

Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  

Leu Arg Val Leu Gln Lys Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      

Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         

Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Thr Ile Met 
        115                 120                 125             

Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 

Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 

Ser Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     

Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Ser Gln His Ser Ala 
            180                 185                 190         

Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Lys Cys Gln Leu Gly 
        195                 200                 205             

Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Ala Thr Thr Tyr Pro Asp 
    210                 215                 220                 

Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 

Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     

Thr Ser Ser Lys Val Thr Arg Glu Glu His Phe Gln Leu His His Gln 
            260                 265                 270         

Met His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu 
        275                 280                 285             

Gln Thr Ser Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Phe Thr 
    290                 295                 300                 

Gln Ala Ala Tyr Val Ala Thr Ser Asp Ser Thr Gln Ser Pro Tyr Pro 
305                 310                 315                 320 

Ser Gln His Leu Glu Ala Pro Arg Asp Lys Ser Leu Asp Ser Ser Leu 
                325                 330                 335     

Met Glu Thr Glu Val Asn Leu Asp Ser Tyr Gln Thr Ala Leu Glu Glu 
            340                 345                 350         

Val Leu Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Arg Ala Gln Gly 
        355                 360                 365             

Glu Ile Ser Asn Asp Val Glu Glu Val Lys Glu Gln Phe His Ala His 
    370                 375                 380                 

Glu Gly Phe Met Met Asp Leu Thr Ser His Gln Gly Leu Val Gly Asn 
385                 390                 395                 400 

Val Leu Gln Leu Gly Ser Gln Leu Val Gly Lys Gly Lys Leu Ser Glu 
                405                 410                 415     

Asp Glu Glu Ala Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg 
            420                 425                 430         

Trp Glu Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Lys Leu His 
        435                 440                 445             

Lys Val Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asp Asp 
    450                 455                 460                 

Trp Leu Thr Lys Thr Glu Glu Arg Thr Lys Lys Met Glu Glu Glu Pro 
465                 470                 475                 480 

Phe Gly Pro Asp Leu Glu Asp Leu Lys Cys Gln Val Gln Gln His Lys 
                485                 490                 495     

Val Leu Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu 
            500                 505                 510         

Thr His Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr 
        515                 520                 525             

Ala Ala Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn 
    530                 535                 540                 

Ile Cys Arg Trp Thr Glu Asp Arg Trp Ile Val Leu Gln Asp Ile Leu 
545                 550                 555                 560 

Leu Lys Trp Gln His Phe Thr Glu Glu Gln Cys Leu Phe Ser Thr Trp 
                565                 570                 575     

Leu Ser Glu Lys Glu Asp Ala Met Lys Asn Ile Gln Thr Ser Gly Phe 
            580                 585                 590         

Lys Asp Gln Asn Glu Met Met Ser Ser Leu His Lys Ile Ser Thr Leu 
        595                 600                 605             

Lys Ile Asp Leu Glu Lys Lys Lys Pro Thr Met Glu Lys Leu Ser Ser 
    610                 615                 620                 

Leu Asn Gln Asp Leu Leu Ser Ala Leu Lys Asn Lys Ser Val Thr Gln 
625                 630                 635                 640 

Lys Met Glu Ile Trp Met Glu Asn Phe Ala Gln Arg Trp Asp Asn Leu 
                645                 650                 655     

Thr Gln Lys Leu Glu Lys Ser Ser Ala Gln Ile Ser Gln Ala Val Thr 
            660                 665                 670         

Thr Thr Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr 
        675                 680                 685             

Met Val Thr Thr Arg Glu Gln Ile Met Val Lys His Ala Gln Glu Glu 
    690                 695                 700                 

Leu Pro Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser 
705                 710                 715                 720 

Glu Leu Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp 
                725                 730                 735     

Ile Thr Arg Ser Glu Ala Val Leu Gln Ser Ser Glu Phe Ala Val Tyr 
            740                 745                 750         

Arg Lys Glu Gly Asn Ile Ser Asp Leu Gln Glu Lys Val Asn Ala Ile 
        755                 760                 765             

Ala Arg Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg 
    770                 775                 780                 

Ser Ala Gln Ala Leu Val Glu Gln Met Ala Asn Glu Gly Val Asn Ala 
785                 790                 795                 800 

Glu Ser Ile Arg Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Thr Glu 
                805                 810                 815     

Phe Cys Gln Leu Leu Ser Glu Arg Val Asn Trp Leu Glu Tyr Gln Thr 
            820                 825                 830         

Asn Ile Ile Thr Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr 
        835                 840                 845             

Thr Thr Ala Glu Asn Leu Leu Lys Thr Gln Ser Thr Thr Leu Ser Glu 
    850                 855                 860                 

Pro Thr Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn 
865                 870                 875                 880 

Arg Leu Ser Ala Leu Gln Pro Gln Ile Glu Gln Leu Lys Ile Gln Ser 
                885                 890                 895     

Leu Gln Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp 
            900                 905                 910         

Phe Val Ala Phe Thr Asn His Phe Asn His Ile Phe Asp Gly Val Arg 
        915                 920                 925             

Ala Lys Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met 
    930                 935                 940                 

Arg Tyr Gln Glu Thr Met Ser Ser Ile Arg Thr Trp Ile Gln Gln Ser 
945                 950                 955                 960 

Glu Ser Lys Leu Ser Val Pro Tyr Leu Ser Val Thr Glu Tyr Glu Ile 
                965                 970                 975     

Met Glu Glu Arg Leu Gly Lys Leu Gln Ala Leu Gln Ser Ser Leu Lys 
            980                 985                 990         

Glu Gln Gln Asn Gly Phe Asn Tyr  Leu Ser Asp Thr Val  Lys Glu Met 
        995                 1000                 1005             

Ala Lys  Lys Ala Pro Ser Glu  Ile Cys Gln Lys Tyr  Leu Ser Glu 
    1010                 1015                 1020             

Phe Glu  Glu Ile Glu Gly His  Trp Lys Lys Leu Ser  Ser Gln Leu 
    1025                 1030                 1035             

Val Glu  Ser Cys Gln Lys Leu  Glu Glu His Met Asn  Lys Leu Arg 
    1040                 1045                 1050             

Lys Phe  Gln Asn His Ile Lys  Thr Leu Gln Lys Trp  Met Ala Glu 
    1055                 1060                 1065             

Val Asp  Val Phe Leu Lys Glu  Glu Trp Pro Ala Leu  Gly Asp Ala 
    1070                 1075                 1080             

Glu Ile  Leu Lys Lys Gln Leu  Lys Gln Cys Arg Leu  Leu Val Gly 
    1085                 1090                 1095             

Asp Ile  Gln Thr Ile Gln Pro  Ser Leu Asn Ser Val  Asn Glu Gly 
    1100                 1105                 1110             

Gly Gln  Lys Ile Lys Ser Glu  Ala Glu Leu Glu Phe  Ala Ser Arg 
    1115                 1120                 1125             

Leu Glu  Thr Glu Leu Arg Glu  Leu Asn Thr Gln Trp  Asp His Ile 
    1130                 1135                 1140             

Cys Arg  Gln Val Tyr Thr Arg  Lys Glu Ala Leu Lys  Ala Gly Leu 
    1145                 1150                 1155             

Asp Lys  Thr Val Ser Leu Gln  Lys Asp Leu Ser Glu  Met His Glu 
    1160                 1165                 1170             

Trp Met  Thr Gln Ala Glu Glu  Glu Tyr Leu Glu Arg  Asp Phe Glu 
    1175                 1180                 1185             

Tyr Lys  Thr Pro Asp Glu Leu  Gln Thr Ala Val Glu  Glu Met Lys 
    1190                 1195                 1200             

Arg Ala  Lys Glu Glu Ala Leu  Gln Lys Glu Thr Lys  Val Lys Leu 
    1205                 1210                 1215             

Leu Thr  Glu Thr Val Asn Ser  Val Ile Ala His Ala  Pro Pro Ser 
    1220                 1225                 1230             

Ala Gln  Glu Ala Leu Lys Lys  Glu Leu Glu Thr Leu  Thr Thr Asn 
    1235                 1240                 1245             

Tyr Gln  Trp Leu Cys Thr Arg  Leu Asn Gly Lys Cys  Lys Thr Leu 
    1250                 1255                 1260             

Glu Glu  Val Trp Ala Cys Trp  His Glu Leu Leu Ser  Tyr Leu Glu 
    1265                 1270                 1275             

Lys Ala  Asn Lys Trp Leu Asn  Glu Val Glu Leu Lys  Leu Lys Thr 
    1280                 1285                 1290             

Met Glu  Asn Val Pro Ala Gly  Pro Glu Glu Ile Thr  Glu Val Leu 
    1295                 1300                 1305             

Glu Ser  Leu Glu Asn Leu Met  His His Ser Glu Glu  Asn Pro Asn 
    1310                 1315                 1320             

Gln Ile  Arg Leu Leu Ala Gln  Thr Leu Thr Asp Gly  Gly Val Met 
    1325                 1330                 1335             

Asp Glu  Leu Ile Asn Glu Glu  Leu Glu Thr Phe Asn  Ser Arg Trp 
    1340                 1345                 1350             

Arg Glu  Leu His Glu Glu Ala  Val Arg Lys Gln Lys  Leu Leu Glu 
    1355                 1360                 1365             

Gln Ser  Ile Gln Ser Ala Gln  Glu Ile Glu Lys Ser  Leu His Leu 
    1370                 1375                 1380             

Ile Gln  Glu Ser Leu Glu Phe  Ile Asp Lys Gln Leu  Ala Ala Tyr 
    1385                 1390                 1395             

Ile Thr  Asp Lys Val Asp Ala  Ala Gln Met Pro Gln  Glu Ala Gln 
    1400                 1405                 1410             

Lys Ile  Gln Ser Asp Leu Thr  Ser His Glu Ile Ser  Leu Glu Glu 
    1415                 1420                 1425             

Met Lys  Lys His Asn Gln Gly  Lys Asp Ala Asn Gln  Arg Val Leu 
    1430                 1435                 1440             

Ser Gln  Ile Asp Val Ala Gln  Lys Lys Leu Gln Asp  Val Ser Met 
    1445                 1450                 1455             

Lys Phe  Arg Leu Phe Gln Lys  Pro Ala Asn Phe Glu  Gln Arg Leu 
    1460                 1465                 1470             

Glu Glu  Ser Lys Met Ile Leu  Asp Glu Val Lys Met  His Leu Pro 
    1475                 1480                 1485             

Ala Leu  Glu Thr Lys Ser Val  Glu Gln Glu Val Ile  Gln Ser Gln 
    1490                 1495                 1500             

Leu Ser  His Cys Val Asn Leu  Tyr Lys Ser Leu Ser  Glu Val Lys 
    1505                 1510                 1515             

Ser Glu  Val Glu Met Val Ile  Lys Thr Gly Arg Gln  Ile Val Gln 
    1520                 1525                 1530             

Lys Lys  Gln Thr Glu Asn Pro  Lys Glu Leu Asp Glu  Arg Val Thr 
    1535                 1540                 1545             

Ala Leu  Lys Leu His Tyr Asn  Glu Leu Gly Ala Lys  Val Thr Glu 
    1550                 1555                 1560             

Arg Lys  Gln Gln Leu Glu Lys  Cys Leu Lys Leu Ser  Arg Lys Met 
    1565                 1570                 1575             

Arg Lys  Glu Met Asn Val Leu  Thr Glu Trp Leu Ala  Ala Thr Asp 
    1580                 1585                 1590             

Thr Glu  Leu Thr Lys Arg Ser  Ala Val Glu Gly Met  Pro Ser Asn 
    1595                 1600                 1605             

Leu Asp  Ser Glu Val Ala Trp  Gly Lys Ala Thr Gln  Lys Glu Ile 
    1610                 1615                 1620             

Glu Lys  Gln Lys Ala His Leu  Lys Ser Val Thr Glu  Leu Gly Glu 
    1625                 1630                 1635             

Ser Leu  Lys Met Val Leu Gly  Lys Lys Glu Thr Leu  Val Glu Asp 
    1640                 1645                 1650             

Lys Leu  Ser Leu Leu Asn Ser  Asn Trp Ile Ala Val  Thr Ser Arg 
    1655                 1660                 1665             

Val Glu  Glu Trp Leu Asn Leu  Leu Leu Glu Tyr Gln  Lys His Met 
    1670                 1675                 1680             

Glu Thr  Phe Asp Gln Asn Ile  Glu Gln Ile Thr Lys  Trp Ile Ile 
    1685                 1690                 1695             

His Ala  Asp Glu Leu Leu Asp  Glu Ser Glu Lys Lys  Lys Pro Gln 
    1700                 1705                 1710             

Gln Lys  Glu Asp Ile Leu Lys  Arg Leu Lys Ala Glu  Met Asn Asp 
    1715                 1720                 1725             

Met Arg  Pro Lys Val Asp Ser  Thr Arg Asp Gln Ala  Ala Lys Leu 
    1730                 1735                 1740             

Met Ala  Asn Arg Gly Asp His  Cys Arg Lys Val Val  Glu Pro Gln 
    1745                 1750                 1755             

Ile Ser  Glu Leu Asn Arg Arg  Phe Ala Ala Ile Ser  His Arg Ile 
    1760                 1765                 1770             

Lys Thr  Gly Lys Ala Ser Ile  Pro Leu Lys Glu Leu  Glu Gln Phe 
    1775                 1780                 1785             

Asn Ser  Asp Ile Gln Lys Leu  Leu Glu Pro Leu Glu  Ala Glu Ile 
    1790                 1795                 1800             

Gln Gln  Gly Val Asn Leu Lys  Glu Glu Asp Phe Asn  Lys Asp Met 
    1805                 1810                 1815             

Ser Glu  Asp Asn Glu Gly Thr  Val Asn Glu Leu Leu  Gln Arg Gly 
    1820                 1825                 1830             

Asp Asn  Leu Gln Gln Arg Ile  Thr Asp Glu Arg Lys  Arg Glu Glu 
    1835                 1840                 1845             

Ile Lys  Ile Lys Gln Gln Leu  Leu Gln Thr Lys His  Asn Ala Leu 
    1850                 1855                 1860             

Lys Asp  Leu Arg Ser Gln Arg  Arg Lys Lys Ala Leu  Glu Ile Ser 
    1865                 1870                 1875             

His Gln  Trp Tyr Gln Tyr Lys  Arg Gln Ala Asp Asp  Leu Leu Lys 
    1880                 1885                 1890             

Cys Leu  Asp Glu Ile Glu Lys  Lys Leu Ala Ser Leu  Pro Glu Pro 
    1895                 1900                 1905             

Arg Asp  Glu Arg Lys Leu Lys  Glu Ile Asp Arg Glu  Leu Gln Lys 
    1910                 1915                 1920             

Lys Lys  Glu Glu Leu Asn Ala  Val Arg Arg Gln Ala  Glu Gly Leu 
    1925                 1930                 1935             

Ser Glu  Asn Gly Ala Ala Met  Ala Val Glu Pro Thr  Gln Ile Gln 
    1940                 1945                 1950             

Leu Ser  Lys Arg Trp Arg Gln  Ile Glu Ser Asn Phe  Ala Gln Phe 
    1955                 1960                 1965             

Arg Arg  Leu Asn Phe Ala Gln  Ile His Thr Leu His  Glu Glu Thr 
    1970                 1975                 1980             

Met Val  Val Thr Thr Glu Asp  Met Pro Leu Asp Val  Ser Tyr Val 
    1985                 1990                 1995             

Pro Ser  Thr Tyr Leu Thr Glu  Ile Ser His Ile Leu  Gln Ala Leu 
    2000                 2005                 2010             

Ser Glu  Val Asp His Leu Leu  Asn Thr Pro Glu Leu  Cys Ala Lys 
    2015                 2020                 2025             

Asp Phe  Glu Asp Leu Phe Lys  Gln Glu Glu Ser Leu  Lys Asn Ile 
    2030                 2035                 2040             

Lys Asp  Asn Leu Gln Gln Ile  Ser Gly Arg Ile Asp  Ile Ile His 
    2045                 2050                 2055             

Lys Lys  Lys Thr Ala Ala Leu  Gln Ser Ala Thr Ser  Met Glu Lys 
    2060                 2065                 2070             

Val Lys  Val Gln Glu Ala Val  Ala Gln Met Asp Phe  Gln Gly Glu 
    2075                 2080                 2085             

Lys Leu  His Arg Met Tyr Lys  Glu Arg Gln Gly Arg  Phe Asp Arg 
    2090                 2095                 2100             

Ser Val  Glu Lys Trp Arg His  Phe His Tyr Asp Met  Lys Val Phe 
    2105                 2110                 2115             

Asn Gln  Trp Leu Asn Glu Val  Glu Gln Phe Phe Lys  Lys Thr Gln 
    2120                 2125                 2130             

Asn Pro  Glu Asn Trp Glu His  Ala Lys Tyr Lys Trp  Tyr Leu Lys 
    2135                 2140                 2145             

Glu Leu  Gln Asp Gly Ile Gly  Gln Arg Gln Ala Val  Val Arg Thr 
    2150                 2155                 2160             

Leu Asn  Ala Thr Gly Glu Glu  Ile Ile Gln Gln Ser  Ser Lys Thr 
    2165                 2170                 2175             

Asp Val  Asn Ile Leu Gln Glu  Lys Leu Gly Ser Leu  Ser Leu Arg 
    2180                 2185                 2190             

Trp His  Asp Ile Cys Lys Glu  Leu Ala Glu Arg Arg  Lys Arg Ile 
    2195                 2200                 2205             

Glu Glu  Gln Lys Asn Val Leu  Ser Glu Phe Gln Arg  Asp Leu Asn 
    2210                 2215                 2220             

Glu Phe  Val Leu Trp Leu Glu  Glu Ala Asp Asn Ile  Ala Ile Thr 
    2225                 2230                 2235             

Pro Leu  Gly Asp Glu Gln Gln  Leu Lys Glu Gln Leu  Glu Gln Val 
    2240                 2245                 2250             

Lys Leu  Leu Ala Glu Glu Leu  Pro Leu Arg Gln Gly  Ile Leu Lys 
    2255                 2260                 2265             

Gln Leu  Asn Glu Thr Gly Gly  Ala Val Leu Val Ser  Ala Pro Ile 
    2270                 2275                 2280             

Arg Pro  Glu Glu Gln Asp Lys  Leu Glu Lys Lys Leu  Lys Gln Thr 
    2285                 2290                 2295             

Asn Leu  Gln Trp Ile Lys Val  Ser Arg Ala Leu Pro  Glu Lys Gln 
    2300                 2305                 2310             

Gly Glu  Leu Glu Val His Leu  Lys Asp Phe Arg Gln  Leu Glu Glu 
    2315                 2320                 2325             

Gln Leu  Asp His Leu Leu Leu  Trp Leu Ser Pro Ile  Arg Asn Gln 
    2330                 2335                 2340             

Leu Glu  Ile Tyr Asn Gln Pro  Ser Gln Ala Gly Pro  Phe Asp Ile 
    2345                 2350                 2355             

Lys Glu  Ile Glu Val Thr Val  His Gly Lys Gln Ala  Asp Val Glu 
    2360                 2365                 2370             

Arg Leu  Leu Ser Lys Gly Gln  His Leu Tyr Lys Glu  Lys Pro Ser 
    2375                 2380                 2385             

Thr Gln  Pro Val Lys Arg Lys  Leu Glu Asp Leu Arg  Ser Glu Trp 
    2390                 2395                 2400             

Glu Ala  Val Asn His Leu Leu  Arg Glu Leu Arg Thr  Lys Gln Pro 
    2405                 2410                 2415             

Asp Arg  Ala Pro Gly Leu Ser  Thr Thr Gly Ala Ser  Ala Ser Gln 
    2420                 2425                 2430             

Thr Val  Thr Leu Val Thr Gln  Ser Val Val Thr Lys  Glu Thr Val 
    2435                 2440                 2445             

Ile Ser  Lys Leu Glu Met Pro  Ser Ser Leu Leu Leu  Glu Val Pro 
    2450                 2455                 2460             

Ala Leu  Ala Asp Phe Asn Arg  Ala Trp Thr Glu Leu  Thr Asp Trp 
    2465                 2470                 2475             

Leu Ser  Leu Leu Asp Arg Val  Ile Lys Ser Gln Arg  Val Met Val 
    2480                 2485                 2490             

Gly Asp  Leu Glu Asp Ile Asn  Glu Met Ile Ile Lys  Gln Lys Ala 
    2495                 2500                 2505             

Thr Leu  Gln Asp Leu Glu Gln  Arg Arg Pro Gln Leu  Glu Glu Leu 
    2510                 2515                 2520             

Ile Thr  Ala Ala Gln Asn Leu  Lys Asn Lys Thr Ser  Asn Gln Glu 
    2525                 2530                 2535             

Ala Arg  Thr Ile Ile Thr Asp  Arg Ile Glu Arg Ile  Gln Ile Gln 
    2540                 2545                 2550             

Trp Asp  Glu Val Gln Glu Gln  Leu Gln Asn Arg Arg  Gln Gln Leu 
    2555                 2560                 2565             

Asn Glu  Met Leu Lys Asp Ser  Thr Gln Trp Leu Glu  Ala Lys Glu 
    2570                 2575                 2580             

Glu Ala  Glu Gln Val Ile Gly  Gln Val Arg Gly Lys  Leu Asp Ser 
    2585                 2590                 2595             

Trp Lys  Glu Gly Pro His Thr  Val Asp Ala Ile Gln  Lys Lys Ile 
    2600                 2605                 2610             

Thr Glu  Thr Lys Gln Leu Ala  Lys Asp Leu Arg Gln  Arg Gln Ile 
    2615                 2620                 2625             

Ser Val  Asp Val Ala Asn Asp  Leu Ala Leu Lys Leu  Leu Arg Asp 
    2630                 2635                 2640             

Tyr Ser  Ala Asp Asp Thr Arg  Lys Val His Met Ile  Thr Glu Asn 
    2645                 2650                 2655             

Ile Asn  Thr Ser Trp Gly Asn  Ile His Lys Arg Val  Ser Glu Gln 
    2660                 2665                 2670             

Glu Ala  Ala Leu Glu Glu Thr  His Arg Leu Leu Gln  Gln Phe Pro 
    2675                 2680                 2685             

Leu Asp  Leu Glu Lys Phe Leu  Ser Trp Ile Thr Glu  Ala Glu Thr 
    2690                 2695                 2700             

Thr Ala  Asn Val Leu Gln Asp  Ala Ser Arg Lys Glu  Lys Leu Leu 
    2705                 2710                 2715             

Glu Asp  Ser Arg Gly Val Arg  Glu Leu Met Lys Pro  Trp Gln Asp 
    2720                 2725                 2730             

Leu Gln  Gly Glu Ile Glu Thr  His Thr Asp Ile Tyr  His Asn Leu 
    2735                 2740                 2745             

Asp Glu  Asn Gly Gln Lys Ile  Leu Arg Ser Leu Glu  Gly Ser Asp 
    2750                 2755                 2760             

Glu Ala  Pro Leu Leu Gln Arg  Arg Leu Asp Asn Met  Asn Phe Lys 
    2765                 2770                 2775             

Trp Ser  Glu Leu Gln Lys Lys  Ser Leu Asn Ile Arg  Ser His Leu 
    2780                 2785                 2790             

Glu Ala  Ser Ser Asp Gln Trp  Lys Arg Leu His Leu  Ser Leu Gln 
    2795                 2800                 2805             

Glu Leu  Leu Val Trp Leu Gln  Leu Lys Asp Asp Glu  Leu Ser Arg 
    2810                 2815                 2820             

Gln Ala  Pro Ile Gly Gly Asp  Phe Pro Ala Val Gln  Lys Gln Asn 
    2825                 2830                 2835             

Asp Ile  His Arg Ala Phe Lys  Arg Glu Leu Lys Thr  Lys Glu Pro 
    2840                 2845                 2850             

Val Ile  Met Ser Thr Leu Glu  Thr Val Arg Ile Phe  Leu Thr Glu 
    2855                 2860                 2865             

Gln Pro  Leu Glu Gly Leu Glu  Lys Leu Tyr Gln Glu  Pro Arg Glu 
    2870                 2875                 2880             

Leu Pro  Pro Glu Glu Arg Ala  Gln Asn Val Thr Arg  Leu Leu Arg 
    2885                 2890                 2895             

Lys Gln  Ala Glu Glu Val Asn  Ala Glu Trp Asp Lys  Leu Asn Leu 
    2900                 2905                 2910             

Arg Ser  Ala Asp Trp Gln Arg  Lys Ile Asp Glu Ala  Leu Glu Arg 
    2915                 2920                 2925             

Leu Gln  Glu Leu Gln Glu Ala  Ala Asp Glu Leu Asp  Leu Lys Leu 
    2930                 2935                 2940             

Arg Gln  Ala Glu Val Ile Lys  Gly Ser Trp Gln Pro  Val Gly Asp 
    2945                 2950                 2955             

Leu Leu  Ile Asp Ser Leu Gln  Asp His Leu Glu Lys  Val Lys Ala 
    2960                 2965                 2970             

Leu Arg  Gly Glu Ile Ala Pro  Leu Lys Glu Asn Val  Asn Arg Val 
    2975                 2980                 2985             

Asn Asp  Leu Ala His Gln Leu  Thr Thr Leu Gly Ile  Gln Leu Ser 
    2990                 2995                 3000             

Pro Tyr  Asn Leu Ser Thr Leu  Glu Asp Leu Asn Thr  Arg Trp Arg 
    3005                 3010                 3015             

Leu Leu  Gln Val Ala Val Glu  Asp Arg Val Arg Gln  Leu His Glu 
    3020                 3025                 3030             

Ala His  Arg Asp Phe Gly Pro  Ala Ser Gln His Phe  Leu Ser Thr 
    3035                 3040                 3045             

Ser Val  Gln Gly Pro Trp Glu  Arg Ala Ile Ser Pro  Asn Lys Val 
    3050                 3055                 3060             

Pro Tyr  Tyr Ile Asn His Glu  Thr Gln Thr Thr Cys  Trp Asp His 
    3065                 3070                 3075             

Pro Lys  Met Thr Glu Leu Tyr  Gln Ser Leu Ala Asp  Leu Asn Asn 
    3080                 3085                 3090             

Val Arg  Phe Ser Ala Tyr Arg  Thr Ala Met Lys Leu  Arg Arg Leu 
    3095                 3100                 3105             

Gln Lys  Ala Leu Cys Leu Asp  Leu Leu Ser Leu Ser  Ala Ala Cys 
    3110                 3115                 3120             

Asp Ala  Leu Asp Gln His Asn  Leu Lys Gln Asn Asp  Gln Pro Met 
    3125                 3130                 3135             

Asp Ile  Leu Gln Ile Ile Asn  Cys Leu Thr Thr Ile  Tyr Asp Arg 
    3140                 3145                 3150             

Leu Glu  Gln Glu His Asn Asn  Leu Val Asn Val Pro  Leu Cys Val 
    3155                 3160                 3165             

Asp Met  Cys Leu Asn Trp Leu  Leu Asn Val Tyr Asp  Thr Gly Arg 
    3170                 3175                 3180             

Thr Gly  Arg Ile Arg Val Leu  Ser Phe Lys Thr Gly  Ile Ile Ser 
    3185                 3190                 3195             

Leu Cys  Lys Ala His Leu Glu  Asp Lys Tyr Arg Tyr  Leu Phe Lys 
    3200                 3205                 3210             

Gln Val  Ala Ser Ser Thr Gly  Phe Cys Asp Gln Arg  Arg Leu Gly 
    3215                 3220                 3225             

Leu Leu  Leu His Asp Ser Ile  Gln Ile Pro Arg Gln  Leu Gly Glu 
    3230                 3235                 3240             

Val Ala  Ser Phe Gly Gly Ser  Asn Ile Glu Pro Ser  Val Arg Ser 
    3245                 3250                 3255             

Cys Phe  Gln Phe Ala Asn Asn  Lys Pro Glu Ile Glu  Ala Ala Leu 
    3260                 3265                 3270             

Phe Leu  Asp Trp Met Arg Leu  Glu Pro Gln Ser Met  Val Trp Leu 
    3275                 3280                 3285             

Pro Val  Leu His Arg Val Ala  Ala Ala Glu Thr Ala  Lys His Gln 
    3290                 3295                 3300             

Ala Lys  Cys Asn Ile Cys Lys  Glu Cys Pro Ile Ile  Gly Phe Arg 
    3305                 3310                 3315             

Tyr Arg  Ser Leu Lys His Phe  Asn Tyr Asp Ile Cys  Gln Ser Cys 
    3320                 3325                 3330             

Phe Phe  Ser Gly Arg Val Ala  Lys Gly His Lys Met  His Tyr Pro 
    3335                 3340                 3345             

Met Val  Glu Tyr Cys Thr Pro  Thr Thr Ser Gly Glu  Asp Val Arg 
    3350                 3355                 3360             

Asp Phe  Ala Lys Val Leu Lys  Asn Lys Phe Arg Thr  Lys Arg Tyr 
    3365                 3370                 3375             

Phe Ala  Lys His Pro Arg Met  Gly Tyr Leu Pro Val  Gln Thr Val 
    3380                 3385                 3390             

Leu Glu  Gly Asp Asn Met Glu  Thr Pro Val Thr Leu  Ile Asn Phe 
    3395                 3400                 3405             

Trp Pro  Val Asp Ser Ala Pro  Ala Ser Ser Pro Gln  Leu Ser His 
    3410                 3415                 3420             

Asp Asp  Thr His Ser Arg Ile  Glu His Tyr Ala Ser  Arg Leu Ala 
    3425                 3430                 3435             

Glu Met  Glu Asn Ser Asn Gly  Ser Tyr Leu Asn Asp  Ser Ile Ser 
    3440                 3445                 3450             

Pro Asn  Glu Ser Ile Asp Asp  Glu His Leu Leu Ile  Gln His Tyr 
    3455                 3460                 3465             

Cys Gln  Ser Leu Asn Gln Asp  Ser Pro Leu Ser Gln  Pro Arg Ser 
    3470                 3475                 3480             

Pro Ala  Gln Ile Leu Ile Ser  Leu Glu Ser Glu Glu  Arg Gly Glu 
    3485                 3490                 3495             

Leu Glu  Arg Ile Leu Ala Asp  Leu Glu Glu Glu Asn  Arg Asn Leu 
    3500                 3505                 3510             

Gln Ala  Glu Tyr Asp Arg Leu  Lys Gln Gln His Glu  His Lys Gly 
    3515                 3520                 3525             

Leu Ser  Pro Leu Pro Ser Pro  Pro Glu Met Met Pro  Thr Ser Pro 
    3530                 3535                 3540             

Gln Ser  Pro Arg Asp Ala Glu  Leu Ile Ala Glu Ala  Lys Leu Leu 
    3545                 3550                 3555             

Arg Gln  His Lys Gly Arg Leu  Glu Ala Arg Met Gln  Ile Leu Glu 
    3560                 3565                 3570             

Asp His  Asn Lys Gln Leu Glu  Ser Gln Leu His Arg  Leu Arg Gln 
    3575                 3580                 3585             

Leu Leu  Glu Gln Pro Gln Ala  Glu Ala Lys Val Asn  Gly Thr Thr 
    3590                 3595                 3600             

Val Ser  Ser Pro Ser Thr Ser  Leu Gln Arg Ser Asp  Ser Ser Gln 
    3605                 3610                 3615             

Pro Met  Leu Leu Arg Val Val  Gly Ser Gln Thr Ser  Glu Ser Met 
    3620                 3625                 3630             

Gly Glu  Glu Asp Leu Leu Ser  Pro Pro Gln Asp Thr  Ser Thr Gly 
    3635                 3640                 3645             

Leu Glu  Glu Val Met Glu Gln  Leu Asn Asn Ser Phe  Pro Ser Ser 
    3650                 3655                 3660             

Arg Gly  Arg Asn Ala Pro Gly  Lys Pro Met Arg Glu  Asp Thr Met 
    3665                 3670                 3675             


<210>  6
<211>  3685
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Protein sequence of the human dystrophin gene DMD

<400>  6

Met Leu Trp Trp Glu Glu Val Glu Asp Cys Tyr Glu Arg Glu Asp Val 
1               5                   10                  15      

Gln Lys Lys Thr Phe Thr Lys Trp Val Asn Ala Gln Phe Ser Lys Phe 
            20                  25                  30          

Gly Lys Gln His Ile Glu Asn Leu Phe Ser Asp Leu Gln Asp Gly Arg 
        35                  40                  45              

Arg Leu Leu Asp Leu Leu Glu Gly Leu Thr Gly Gln Lys Leu Pro Lys 
    50                  55                  60                  

Glu Lys Gly Ser Thr Arg Val His Ala Leu Asn Asn Val Asn Lys Ala 
65                  70                  75                  80  

Leu Arg Val Leu Gln Asn Asn Asn Val Asp Leu Val Asn Ile Gly Ser 
                85                  90                  95      

Thr Asp Ile Val Asp Gly Asn His Lys Leu Thr Leu Gly Leu Ile Trp 
            100                 105                 110         

Asn Ile Ile Leu His Trp Gln Val Lys Asn Val Met Lys Asn Ile Met 
        115                 120                 125             

Ala Gly Leu Gln Gln Thr Asn Ser Glu Lys Ile Leu Leu Ser Trp Val 
    130                 135                 140                 

Arg Gln Ser Thr Arg Asn Tyr Pro Gln Val Asn Val Ile Asn Phe Thr 
145                 150                 155                 160 

Thr Ser Trp Ser Asp Gly Leu Ala Leu Asn Ala Leu Ile His Ser His 
                165                 170                 175     

Arg Pro Asp Leu Phe Asp Trp Asn Ser Val Val Cys Gln Gln Ser Ala 
            180                 185                 190         

Thr Gln Arg Leu Glu His Ala Phe Asn Ile Ala Arg Tyr Gln Leu Gly 
        195                 200                 205             

Ile Glu Lys Leu Leu Asp Pro Glu Asp Val Asp Thr Thr Tyr Pro Asp 
    210                 215                 220                 

Lys Lys Ser Ile Leu Met Tyr Ile Thr Ser Leu Phe Gln Val Leu Pro 
225                 230                 235                 240 

Gln Gln Val Ser Ile Glu Ala Ile Gln Glu Val Glu Met Leu Pro Arg 
                245                 250                 255     

Pro Pro Lys Val Thr Lys Glu Glu His Phe Gln Leu His His Gln Met 
            260                 265                 270         

His Tyr Ser Gln Gln Ile Thr Val Ser Leu Ala Gln Gly Tyr Glu Arg 
        275                 280                 285             

Thr Ser Ser Pro Lys Pro Arg Phe Lys Ser Tyr Ala Tyr Thr Gln Ala 
    290                 295                 300                 

Ala Tyr Val Thr Thr Ser Asp Pro Thr Arg Ser Pro Phe Pro Ser Gln 
305                 310                 315                 320 

His Leu Glu Ala Pro Glu Asp Lys Ser Phe Gly Ser Ser Leu Met Glu 
                325                 330                 335     

Ser Glu Val Asn Leu Asp Arg Tyr Gln Thr Ala Leu Glu Glu Val Leu 
            340                 345                 350         

Ser Trp Leu Leu Ser Ala Glu Asp Thr Leu Gln Ala Gln Gly Glu Ile 
        355                 360                 365             

Ser Asn Asp Val Glu Val Val Lys Asp Gln Phe His Thr His Glu Gly 
    370                 375                 380                 

Tyr Met Met Asp Leu Thr Ala His Gln Gly Arg Val Gly Asn Ile Leu 
385                 390                 395                 400 

Gln Leu Gly Ser Lys Leu Ile Gly Thr Gly Lys Leu Ser Glu Asp Glu 
                405                 410                 415     

Glu Thr Glu Val Gln Glu Gln Met Asn Leu Leu Asn Ser Arg Trp Glu 
            420                 425                 430         

Cys Leu Arg Val Ala Ser Met Glu Lys Gln Ser Asn Leu His Arg Val 
        435                 440                 445             

Leu Met Asp Leu Gln Asn Gln Lys Leu Lys Glu Leu Asn Asp Trp Leu 
    450                 455                 460                 

Thr Lys Thr Glu Glu Arg Thr Arg Lys Met Glu Glu Glu Pro Leu Gly 
465                 470                 475                 480 

Pro Asp Leu Glu Asp Leu Lys Arg Gln Val Gln Gln His Lys Val Leu 
                485                 490                 495     

Gln Glu Asp Leu Glu Gln Glu Gln Val Arg Val Asn Ser Leu Thr His 
            500                 505                 510         

Met Val Val Val Val Asp Glu Ser Ser Gly Asp His Ala Thr Ala Ala 
        515                 520                 525             

Leu Glu Glu Gln Leu Lys Val Leu Gly Asp Arg Trp Ala Asn Ile Cys 
    530                 535                 540                 

Arg Trp Thr Glu Asp Arg Trp Val Leu Leu Gln Asp Ile Leu Leu Lys 
545                 550                 555                 560 

Trp Gln Arg Leu Thr Glu Glu Gln Cys Leu Phe Ser Ala Trp Leu Ser 
                565                 570                 575     

Glu Lys Glu Asp Ala Val Asn Lys Ile His Thr Thr Gly Phe Lys Asp 
            580                 585                 590         

Gln Asn Glu Met Leu Ser Ser Leu Gln Lys Leu Ala Val Leu Lys Ala 
        595                 600                 605             

Asp Leu Glu Lys Lys Lys Gln Ser Met Gly Lys Leu Tyr Ser Leu Lys 
    610                 615                 620                 

Gln Asp Leu Leu Ser Thr Leu Lys Asn Lys Ser Val Thr Gln Lys Thr 
625                 630                 635                 640 

Glu Ala Trp Leu Asp Asn Phe Ala Arg Cys Trp Asp Asn Leu Val Gln 
                645                 650                 655     

Lys Leu Glu Lys Ser Thr Ala Gln Ile Ser Gln Ala Val Thr Thr Thr 
            660                 665                 670         

Gln Pro Ser Leu Thr Gln Thr Thr Val Met Glu Thr Val Thr Thr Val 
        675                 680                 685             

Thr Thr Arg Glu Gln Ile Leu Val Lys His Ala Gln Glu Glu Leu Pro 
    690                 695                 700                 

Pro Pro Pro Pro Gln Lys Lys Arg Gln Ile Thr Val Asp Ser Glu Ile 
705                 710                 715                 720 

Arg Lys Arg Leu Asp Val Asp Ile Thr Glu Leu His Ser Trp Ile Thr 
                725                 730                 735     

Arg Ser Glu Ala Val Leu Gln Ser Pro Glu Phe Ala Ile Phe Arg Lys 
            740                 745                 750         

Glu Gly Asn Phe Ser Asp Leu Lys Glu Lys Val Asn Ala Ile Glu Arg 
        755                 760                 765             

Glu Lys Ala Glu Lys Phe Arg Lys Leu Gln Asp Ala Ser Arg Ser Ala 
    770                 775                 780                 

Gln Ala Leu Val Glu Gln Met Val Asn Glu Gly Val Asn Ala Asp Ser 
785                 790                 795                 800 

Ile Lys Gln Ala Ser Glu Gln Leu Asn Ser Arg Trp Ile Glu Phe Cys 
                805                 810                 815     

Gln Leu Leu Ser Glu Arg Leu Asn Trp Leu Glu Tyr Gln Asn Asn Ile 
            820                 825                 830         

Ile Ala Phe Tyr Asn Gln Leu Gln Gln Leu Glu Gln Met Thr Thr Thr 
        835                 840                 845             

Ala Glu Asn Trp Leu Lys Ile Gln Pro Thr Thr Pro Ser Glu Pro Thr 
    850                 855                 860                 

Ala Ile Lys Ser Gln Leu Lys Ile Cys Lys Asp Glu Val Asn Arg Leu 
865                 870                 875                 880 

Ser Gly Leu Gln Pro Gln Ile Glu Arg Leu Lys Ile Gln Ser Ile Ala 
                885                 890                 895     

Leu Lys Glu Lys Gly Gln Gly Pro Met Phe Leu Asp Ala Asp Phe Val 
            900                 905                 910         

Ala Phe Thr Asn His Phe Lys Gln Val Phe Ser Asp Val Gln Ala Arg 
        915                 920                 925             

Glu Lys Glu Leu Gln Thr Ile Phe Asp Thr Leu Pro Pro Met Arg Tyr 
    930                 935                 940                 

Gln Glu Thr Met Ser Ala Ile Arg Thr Trp Val Gln Gln Ser Glu Thr 
945                 950                 955                 960 

Lys Leu Ser Ile Pro Gln Leu Ser Val Thr Asp Tyr Glu Ile Met Glu 
                965                 970                 975     

Gln Arg Leu Gly Glu Leu Gln Ala Leu Gln Ser Ser Leu Gln Glu Gln 
            980                 985                 990         

Gln Ser Gly Leu Tyr Tyr Leu Ser  Thr Thr Val Lys Glu  Met Ser Lys 
        995                 1000                 1005             

Lys Ala  Pro Ser Glu Ile Ser  Arg Lys Tyr Gln Ser  Glu Phe Glu 
    1010                 1015                 1020             

Glu Ile  Glu Gly Arg Trp Lys  Lys Leu Ser Ser Gln  Leu Val Glu 
    1025                 1030                 1035             

His Cys  Gln Lys Leu Glu Glu  Gln Met Asn Lys Leu  Arg Lys Ile 
    1040                 1045                 1050             

Gln Asn  His Ile Gln Thr Leu  Lys Lys Trp Met Ala  Glu Val Asp 
    1055                 1060                 1065             

Val Phe  Leu Lys Glu Glu Trp  Pro Ala Leu Gly Asp  Ser Glu Ile 
    1070                 1075                 1080             

Leu Lys  Lys Gln Leu Lys Gln  Cys Arg Leu Leu Val  Ser Asp Ile 
    1085                 1090                 1095             

Gln Thr  Ile Gln Pro Ser Leu  Asn Ser Val Asn Glu  Gly Gly Gln 
    1100                 1105                 1110             

Lys Ile  Lys Asn Glu Ala Glu  Pro Glu Phe Ala Ser  Arg Leu Glu 
    1115                 1120                 1125             

Thr Glu  Leu Lys Glu Leu Asn  Thr Gln Trp Asp His  Met Cys Gln 
    1130                 1135                 1140             

Gln Val  Tyr Ala Arg Lys Glu  Ala Leu Lys Gly Gly  Leu Glu Lys 
    1145                 1150                 1155             

Thr Val  Ser Leu Gln Lys Asp  Leu Ser Glu Met His  Glu Trp Met 
    1160                 1165                 1170             

Thr Gln  Ala Glu Glu Glu Tyr  Leu Glu Arg Asp Phe  Glu Tyr Lys 
    1175                 1180                 1185             

Thr Pro  Asp Glu Leu Gln Lys  Ala Val Glu Glu Met  Lys Arg Ala 
    1190                 1195                 1200             

Lys Glu  Glu Ala Gln Gln Lys  Glu Ala Lys Val Lys  Leu Leu Thr 
    1205                 1210                 1215             

Glu Ser  Val Asn Ser Val Ile  Ala Gln Ala Pro Pro  Val Ala Gln 
    1220                 1225                 1230             

Glu Ala  Leu Lys Lys Glu Leu  Glu Thr Leu Thr Thr  Asn Tyr Gln 
    1235                 1240                 1245             

Trp Leu  Cys Thr Arg Leu Asn  Gly Lys Cys Lys Thr  Leu Glu Glu 
    1250                 1255                 1260             

Val Trp  Ala Cys Trp His Glu  Leu Leu Ser Tyr Leu  Glu Lys Ala 
    1265                 1270                 1275             

Asn Lys  Trp Leu Asn Glu Val  Glu Phe Lys Leu Lys  Thr Thr Glu 
    1280                 1285                 1290             

Asn Ile  Pro Gly Gly Ala Glu  Glu Ile Ser Glu Val  Leu Asp Ser 
    1295                 1300                 1305             

Leu Glu  Asn Leu Met Arg His  Ser Glu Asp Asn Pro  Asn Gln Ile 
    1310                 1315                 1320             

Arg Ile  Leu Ala Gln Thr Leu  Thr Asp Gly Gly Val  Met Asp Glu 
    1325                 1330                 1335             

Leu Ile  Asn Glu Glu Leu Glu  Thr Phe Asn Ser Arg  Trp Arg Glu 
    1340                 1345                 1350             

Leu His  Glu Glu Ala Val Arg  Arg Gln Lys Leu Leu  Glu Gln Ser 
    1355                 1360                 1365             

Ile Gln  Ser Ala Gln Glu Thr  Glu Lys Ser Leu His  Leu Ile Gln 
    1370                 1375                 1380             

Glu Ser  Leu Thr Phe Ile Asp  Lys Gln Leu Ala Ala  Tyr Ile Ala 
    1385                 1390                 1395             

Asp Lys  Val Asp Ala Ala Gln  Met Pro Gln Glu Ala  Gln Lys Ile 
    1400                 1405                 1410             

Gln Ser  Asp Leu Thr Ser His  Glu Ile Ser Leu Glu  Glu Met Lys 
    1415                 1420                 1425             

Lys His  Asn Gln Gly Lys Glu  Ala Ala Gln Arg Val  Leu Ser Gln 
    1430                 1435                 1440             

Ile Asp  Val Ala Gln Lys Lys  Leu Gln Asp Val Ser  Met Lys Phe 
    1445                 1450                 1455             

Arg Leu  Phe Gln Lys Pro Ala  Asn Phe Glu Gln Arg  Leu Gln Glu 
    1460                 1465                 1470             

Ser Lys  Met Ile Leu Asp Glu  Val Lys Met His Leu  Pro Ala Leu 
    1475                 1480                 1485             

Glu Thr  Lys Ser Val Glu Gln  Glu Val Val Gln Ser  Gln Leu Asn 
    1490                 1495                 1500             

His Cys  Val Asn Leu Tyr Lys  Ser Leu Ser Glu Val  Lys Ser Glu 
    1505                 1510                 1515             

Val Glu  Met Val Ile Lys Thr  Gly Arg Gln Ile Val  Gln Lys Lys 
    1520                 1525                 1530             

Gln Thr  Glu Asn Pro Lys Glu  Leu Asp Glu Arg Val  Thr Ala Leu 
    1535                 1540                 1545             

Lys Leu  His Tyr Asn Glu Leu  Gly Ala Lys Val Thr  Glu Arg Lys 
    1550                 1555                 1560             

Gln Gln  Leu Glu Lys Cys Leu  Lys Leu Ser Arg Lys  Met Arg Lys 
    1565                 1570                 1575             

Glu Met  Asn Val Leu Thr Glu  Trp Leu Ala Ala Thr  Asp Met Glu 
    1580                 1585                 1590             

Leu Thr  Lys Arg Ser Ala Val  Glu Gly Met Pro Ser  Asn Leu Asp 
    1595                 1600                 1605             

Ser Glu  Val Ala Trp Gly Lys  Ala Thr Gln Lys Glu  Ile Glu Lys 
    1610                 1615                 1620             

Gln Lys  Val His Leu Lys Ser  Ile Thr Glu Val Gly  Glu Ala Leu 
    1625                 1630                 1635             

Lys Thr  Val Leu Gly Lys Lys  Glu Thr Leu Val Glu  Asp Lys Leu 
    1640                 1645                 1650             

Ser Leu  Leu Asn Ser Asn Trp  Ile Ala Val Thr Ser  Arg Ala Glu 
    1655                 1660                 1665             

Glu Trp  Leu Asn Leu Leu Leu  Glu Tyr Gln Lys His  Met Glu Thr 
    1670                 1675                 1680             

Phe Asp  Gln Asn Val Asp His  Ile Thr Lys Trp Ile  Ile Gln Ala 
    1685                 1690                 1695             

Asp Thr  Leu Leu Asp Glu Ser  Glu Lys Lys Lys Pro  Gln Gln Lys 
    1700                 1705                 1710             

Glu Asp  Val Leu Lys Arg Leu  Lys Ala Glu Leu Asn  Asp Ile Arg 
    1715                 1720                 1725             

Pro Lys  Val Asp Ser Thr Arg  Asp Gln Ala Ala Asn  Leu Met Ala 
    1730                 1735                 1740             

Asn Arg  Gly Asp His Cys Arg  Lys Leu Val Glu Pro  Gln Ile Ser 
    1745                 1750                 1755             

Glu Leu  Asn His Arg Phe Ala  Ala Ile Ser His Arg  Ile Lys Thr 
    1760                 1765                 1770             

Gly Lys  Ala Ser Ile Pro Leu  Lys Glu Leu Glu Gln  Phe Asn Ser 
    1775                 1780                 1785             

Asp Ile  Gln Lys Leu Leu Glu  Pro Leu Glu Ala Glu  Ile Gln Gln 
    1790                 1795                 1800             

Gly Val  Asn Leu Lys Glu Glu  Asp Phe Asn Lys Asp  Met Asn Glu 
    1805                 1810                 1815             

Asp Asn  Glu Gly Thr Val Lys  Glu Leu Leu Gln Arg  Gly Asp Asn 
    1820                 1825                 1830             

Leu Gln  Gln Arg Ile Thr Asp  Glu Arg Lys Arg Glu  Glu Ile Lys 
    1835                 1840                 1845             

Ile Lys  Gln Gln Leu Leu Gln  Thr Lys His Asn Ala  Leu Lys Asp 
    1850                 1855                 1860             

Leu Arg  Ser Gln Arg Arg Lys  Lys Ala Leu Glu Ile  Ser His Gln 
    1865                 1870                 1875             

Trp Tyr  Gln Tyr Lys Arg Gln  Ala Asp Asp Leu Leu  Lys Cys Leu 
    1880                 1885                 1890             

Asp Asp  Ile Glu Lys Lys Leu  Ala Ser Leu Pro Glu  Pro Arg Asp 
    1895                 1900                 1905             

Glu Arg  Lys Ile Lys Glu Ile  Asp Arg Glu Leu Gln  Lys Lys Lys 
    1910                 1915                 1920             

Glu Glu  Leu Asn Ala Val Arg  Arg Gln Ala Glu Gly  Leu Ser Glu 
    1925                 1930                 1935             

Asp Gly  Ala Ala Met Ala Val  Glu Pro Thr Gln Ile  Gln Leu Ser 
    1940                 1945                 1950             

Lys Arg  Trp Arg Glu Ile Glu  Ser Lys Phe Ala Gln  Phe Arg Arg 
    1955                 1960                 1965             

Leu Asn  Phe Ala Gln Ile His  Thr Val Arg Glu Glu  Thr Met Met 
    1970                 1975                 1980             

Val Met  Thr Glu Asp Met Pro  Leu Glu Ile Ser Tyr  Val Pro Ser 
    1985                 1990                 1995             

Thr Tyr  Leu Thr Glu Ile Thr  His Val Ser Gln Ala  Leu Leu Glu 
    2000                 2005                 2010             

Val Glu  Gln Leu Leu Asn Ala  Pro Asp Leu Cys Ala  Lys Asp Phe 
    2015                 2020                 2025             

Glu Asp  Leu Phe Lys Gln Glu  Glu Ser Leu Lys Asn  Ile Lys Asp 
    2030                 2035                 2040             

Ser Leu  Gln Gln Ser Ser Gly  Arg Ile Asp Ile Ile  His Ser Lys 
    2045                 2050                 2055             

Lys Thr  Ala Ala Leu Gln Ser  Ala Thr Pro Val Glu  Arg Val Lys 
    2060                 2065                 2070             

Leu Gln  Glu Ala Leu Ser Gln  Leu Asp Phe Gln Trp  Glu Lys Val 
    2075                 2080                 2085             

Asn Lys  Met Tyr Lys Asp Arg  Gln Gly Arg Phe Asp  Arg Ser Val 
    2090                 2095                 2100             

Glu Lys  Trp Arg Arg Phe His  Tyr Asp Ile Lys Ile  Phe Asn Gln 
    2105                 2110                 2115             

Trp Leu  Thr Glu Ala Glu Gln  Phe Leu Arg Lys Thr  Gln Ile Pro 
    2120                 2125                 2130             

Glu Asn  Trp Glu His Ala Lys  Tyr Lys Trp Tyr Leu  Lys Glu Leu 
    2135                 2140                 2145             

Gln Asp  Gly Ile Gly Gln Arg  Gln Thr Val Val Arg  Thr Leu Asn 
    2150                 2155                 2160             

Ala Thr  Gly Glu Glu Ile Ile  Gln Gln Ser Ser Lys  Thr Asp Ala 
    2165                 2170                 2175             

Ser Ile  Leu Gln Glu Lys Leu  Gly Ser Leu Asn Leu  Arg Trp Gln 
    2180                 2185                 2190             

Glu Val  Cys Lys Gln Leu Ser  Asp Arg Lys Lys Arg  Leu Glu Glu 
    2195                 2200                 2205             

Gln Lys  Asn Ile Leu Ser Glu  Phe Gln Arg Asp Leu  Asn Glu Phe 
    2210                 2215                 2220             

Val Leu  Trp Leu Glu Glu Ala  Asp Asn Ile Ala Ser  Ile Pro Leu 
    2225                 2230                 2235             

Glu Pro  Gly Lys Glu Gln Gln  Leu Lys Glu Lys Leu  Glu Gln Val 
    2240                 2245                 2250             

Lys Leu  Leu Val Glu Glu Leu  Pro Leu Arg Gln Gly  Ile Leu Lys 
    2255                 2260                 2265             

Gln Leu  Asn Glu Thr Gly Gly  Pro Val Leu Val Ser  Ala Pro Ile 
    2270                 2275                 2280             

Ser Pro  Glu Glu Gln Asp Lys  Leu Glu Asn Lys Leu  Lys Gln Thr 
    2285                 2290                 2295             

Asn Leu  Gln Trp Ile Lys Val  Ser Arg Ala Leu Pro  Glu Lys Gln 
    2300                 2305                 2310             

Gly Glu  Ile Glu Ala Gln Ile  Lys Asp Leu Gly Gln  Leu Glu Lys 
    2315                 2320                 2325             

Lys Leu  Glu Asp Leu Glu Glu  Gln Leu Asn His Leu  Leu Leu Trp 
    2330                 2335                 2340             

Leu Ser  Pro Ile Arg Asn Gln  Leu Glu Ile Tyr Asn  Gln Pro Asn 
    2345                 2350                 2355             

Gln Glu  Gly Pro Phe Asp Val  Gln Glu Thr Glu Ile  Ala Val Gln 
    2360                 2365                 2370             

Ala Lys  Gln Pro Asp Val Glu  Glu Ile Leu Ser Lys  Gly Gln His 
    2375                 2380                 2385             

Leu Tyr  Lys Glu Lys Pro Ala  Thr Gln Pro Val Lys  Arg Lys Leu 
    2390                 2395                 2400             

Glu Asp  Leu Ser Ser Glu Trp  Lys Ala Val Asn Arg  Leu Leu Gln 
    2405                 2410                 2415             

Glu Leu  Arg Ala Lys Gln Pro  Asp Leu Ala Pro Gly  Leu Thr Thr 
    2420                 2425                 2430             

Ile Gly  Ala Ser Pro Thr Gln  Thr Val Thr Leu Val  Thr Gln Pro 
    2435                 2440                 2445             

Val Val  Thr Lys Glu Thr Ala  Ile Ser Lys Leu Glu  Met Pro Ser 
    2450                 2455                 2460             

Ser Leu  Met Leu Glu Val Pro  Ala Leu Ala Asp Phe  Asn Arg Ala 
    2465                 2470                 2475             

Trp Thr  Glu Leu Thr Asp Trp  Leu Ser Leu Leu Asp  Gln Val Ile 
    2480                 2485                 2490             

Lys Ser  Gln Arg Val Met Val  Gly Asp Leu Glu Asp  Ile Asn Glu 
    2495                 2500                 2505             

Met Ile  Ile Lys Gln Lys Ala  Thr Met Gln Asp Leu  Glu Gln Arg 
    2510                 2515                 2520             

Arg Pro  Gln Leu Glu Glu Leu  Ile Thr Ala Ala Gln  Asn Leu Lys 
    2525                 2530                 2535             

Asn Lys  Thr Ser Asn Gln Glu  Ala Arg Thr Ile Ile  Thr Asp Arg 
    2540                 2545                 2550             

Ile Glu  Arg Ile Gln Asn Gln  Trp Asp Glu Val Gln  Glu His Leu 
    2555                 2560                 2565             

Gln Asn  Arg Arg Gln Gln Leu  Asn Glu Met Leu Lys  Asp Ser Thr 
    2570                 2575                 2580             

Gln Trp  Leu Glu Ala Lys Glu  Glu Ala Glu Gln Val  Leu Gly Gln 
    2585                 2590                 2595             

Ala Arg  Ala Lys Leu Glu Ser  Trp Lys Glu Gly Pro  Tyr Thr Val 
    2600                 2605                 2610             

Asp Ala  Ile Gln Lys Lys Ile  Thr Glu Thr Lys Gln  Leu Ala Lys 
    2615                 2620                 2625             

Asp Leu  Arg Gln Trp Gln Thr  Asn Val Asp Val Ala  Asn Asp Leu 
    2630                 2635                 2640             

Ala Leu  Lys Leu Leu Arg Asp  Tyr Ser Ala Asp Asp  Thr Arg Lys 
    2645                 2650                 2655             

Val His  Met Ile Thr Glu Asn  Ile Asn Ala Ser Trp  Arg Ser Ile 
    2660                 2665                 2670             

His Lys  Arg Val Ser Glu Arg  Glu Ala Ala Leu Glu  Glu Thr His 
    2675                 2680                 2685             

Arg Leu  Leu Gln Gln Phe Pro  Leu Asp Leu Glu Lys  Phe Leu Ala 
    2690                 2695                 2700             

Trp Leu  Thr Glu Ala Glu Thr  Thr Ala Asn Val Leu  Gln Asp Ala 
    2705                 2710                 2715             

Thr Arg  Lys Glu Arg Leu Leu  Glu Asp Ser Lys Gly  Val Lys Glu 
    2720                 2725                 2730             

Leu Met  Lys Gln Trp Gln Asp  Leu Gln Gly Glu Ile  Glu Ala His 
    2735                 2740                 2745             

Thr Asp  Val Tyr His Asn Leu  Asp Glu Asn Ser Gln  Lys Ile Leu 
    2750                 2755                 2760             

Arg Ser  Leu Glu Gly Ser Asp  Asp Ala Val Leu Leu  Gln Arg Arg 
    2765                 2770                 2775             

Leu Asp  Asn Met Asn Phe Lys  Trp Ser Glu Leu Arg  Lys Lys Ser 
    2780                 2785                 2790             

Leu Asn  Ile Arg Ser His Leu  Glu Ala Ser Ser Asp  Gln Trp Lys 
    2795                 2800                 2805             

Arg Leu  His Leu Ser Leu Gln  Glu Leu Leu Val Trp  Leu Gln Leu 
    2810                 2815                 2820             

Lys Asp  Asp Glu Leu Ser Arg  Gln Ala Pro Ile Gly  Gly Asp Phe 
    2825                 2830                 2835             

Pro Ala  Val Gln Lys Gln Asn  Asp Val His Arg Ala  Phe Lys Arg 
    2840                 2845                 2850             

Glu Leu  Lys Thr Lys Glu Pro  Val Ile Met Ser Thr  Leu Glu Thr 
    2855                 2860                 2865             

Val Arg  Ile Phe Leu Thr Glu  Gln Pro Leu Glu Gly  Leu Glu Lys 
    2870                 2875                 2880             

Leu Tyr  Gln Glu Pro Arg Glu  Leu Pro Pro Glu Glu  Arg Ala Gln 
    2885                 2890                 2895             

Asn Val  Thr Arg Leu Leu Arg  Lys Gln Ala Glu Glu  Val Asn Thr 
    2900                 2905                 2910             

Glu Trp  Glu Lys Leu Asn Leu  His Ser Ala Asp Trp  Gln Arg Lys 
    2915                 2920                 2925             

Ile Asp  Glu Thr Leu Glu Arg  Leu Gln Glu Leu Gln  Glu Ala Thr 
    2930                 2935                 2940             

Asp Glu  Leu Asp Leu Lys Leu  Arg Gln Ala Glu Val  Ile Lys Gly 
    2945                 2950                 2955             

Ser Trp  Gln Pro Val Gly Asp  Leu Leu Ile Asp Ser  Leu Gln Asp 
    2960                 2965                 2970             

His Leu  Glu Lys Val Lys Ala  Leu Arg Gly Glu Ile  Ala Pro Leu 
    2975                 2980                 2985             

Lys Glu  Asn Val Ser His Val  Asn Asp Leu Ala Arg  Gln Leu Thr 
    2990                 2995                 3000             

Thr Leu  Gly Ile Gln Leu Ser  Pro Tyr Asn Leu Ser  Thr Leu Glu 
    3005                 3010                 3015             

Asp Leu  Asn Thr Arg Trp Lys  Leu Leu Gln Val Ala  Val Glu Asp 
    3020                 3025                 3030             

Arg Val  Arg Gln Leu His Glu  Ala His Arg Asp Phe  Gly Pro Ala 
    3035                 3040                 3045             

Ser Gln  His Phe Leu Ser Thr  Ser Val Gln Gly Pro  Trp Glu Arg 
    3050                 3055                 3060             

Ala Ile  Ser Pro Asn Lys Val  Pro Tyr Tyr Ile Asn  His Glu Thr 
    3065                 3070                 3075             

Gln Thr  Thr Cys Trp Asp His  Pro Lys Met Thr Glu  Leu Tyr Gln 
    3080                 3085                 3090             

Ser Leu  Ala Asp Leu Asn Asn  Val Arg Phe Ser Ala  Tyr Arg Thr 
    3095                 3100                 3105             

Ala Met  Lys Leu Arg Arg Leu  Gln Lys Ala Leu Cys  Leu Asp Leu 
    3110                 3115                 3120             

Leu Ser  Leu Ser Ala Ala Cys  Asp Ala Leu Asp Gln  His Asn Leu 
    3125                 3130                 3135             

Lys Gln  Asn Asp Gln Pro Met  Asp Ile Leu Gln Ile  Ile Asn Cys 
    3140                 3145                 3150             

Leu Thr  Thr Ile Tyr Asp Arg  Leu Glu Gln Glu His  Asn Asn Leu 
    3155                 3160                 3165             

Val Asn  Val Pro Leu Cys Val  Asp Met Cys Leu Asn  Trp Leu Leu 
    3170                 3175                 3180             

Asn Val  Tyr Asp Thr Gly Arg  Thr Gly Arg Ile Arg  Val Leu Ser 
    3185                 3190                 3195             

Phe Lys  Thr Gly Ile Ile Ser  Leu Cys Lys Ala His  Leu Glu Asp 
    3200                 3205                 3210             

Lys Tyr  Arg Tyr Leu Phe Lys  Gln Val Ala Ser Ser  Thr Gly Phe 
    3215                 3220                 3225             

Cys Asp  Gln Arg Arg Leu Gly  Leu Leu Leu His Asp  Ser Ile Gln 
    3230                 3235                 3240             

Ile Pro  Arg Gln Leu Gly Glu  Val Ala Ser Phe Gly  Gly Ser Asn 
    3245                 3250                 3255             

Ile Glu  Pro Ser Val Arg Ser  Cys Phe Gln Phe Ala  Asn Asn Lys 
    3260                 3265                 3270             

Pro Glu  Ile Glu Ala Ala Leu  Phe Leu Asp Trp Met  Arg Leu Glu 
    3275                 3280                 3285             

Pro Gln  Ser Met Val Trp Leu  Pro Val Leu His Arg  Val Ala Ala 
    3290                 3295                 3300             

Ala Glu  Thr Ala Lys His Gln  Ala Lys Cys Asn Ile  Cys Lys Glu 
    3305                 3310                 3315             

Cys Pro  Ile Ile Gly Phe Arg  Tyr Arg Ser Leu Lys  His Phe Asn 
    3320                 3325                 3330             

Tyr Asp  Ile Cys Gln Ser Cys  Phe Phe Ser Gly Arg  Val Ala Lys 
    3335                 3340                 3345             

Gly His  Lys Met His Tyr Pro  Met Val Glu Tyr Cys  Thr Pro Thr 
    3350                 3355                 3360             

Thr Ser  Gly Glu Asp Val Arg  Asp Phe Ala Lys Val  Leu Lys Asn 
    3365                 3370                 3375             

Lys Phe  Arg Thr Lys Arg Tyr  Phe Ala Lys His Pro  Arg Met Gly 
    3380                 3385                 3390             

Tyr Leu  Pro Val Gln Thr Val  Leu Glu Gly Asp Asn  Met Glu Thr 
    3395                 3400                 3405             

Pro Val  Thr Leu Ile Asn Phe  Trp Pro Val Asp Ser  Ala Pro Ala 
    3410                 3415                 3420             

Ser Ser  Pro Gln Leu Ser His  Asp Asp Thr His Ser  Arg Ile Glu 
    3425                 3430                 3435             

His Tyr  Ala Ser Arg Leu Ala  Glu Met Glu Asn Ser  Asn Gly Ser 
    3440                 3445                 3450             

Tyr Leu  Asn Asp Ser Ile Ser  Pro Asn Glu Ser Ile  Asp Asp Glu 
    3455                 3460                 3465             

His Leu  Leu Ile Gln His Tyr  Cys Gln Ser Leu Asn  Gln Asp Ser 
    3470                 3475                 3480             

Pro Leu  Ser Gln Pro Arg Ser  Pro Ala Gln Ile Leu  Ile Ser Leu 
    3485                 3490                 3495             

Glu Ser  Glu Glu Arg Gly Glu  Leu Glu Arg Ile Leu  Ala Asp Leu 
    3500                 3505                 3510             

Glu Glu  Glu Asn Arg Asn Leu  Gln Ala Glu Tyr Asp  Arg Leu Lys 
    3515                 3520                 3525             

Gln Gln  His Glu His Lys Gly  Leu Ser Pro Leu Pro  Ser Pro Pro 
    3530                 3535                 3540             

Glu Met  Met Pro Thr Ser Pro  Gln Ser Pro Arg Asp  Ala Glu Leu 
    3545                 3550                 3555             

Ile Ala  Glu Ala Lys Leu Leu  Arg Gln His Lys Gly  Arg Leu Glu 
    3560                 3565                 3570             

Ala Arg  Met Gln Ile Leu Glu  Asp His Asn Lys Gln  Leu Glu Ser 
    3575                 3580                 3585             

Gln Leu  His Arg Leu Arg Gln  Leu Leu Glu Gln Pro  Gln Ala Glu 
    3590                 3595                 3600             

Ala Lys  Val Asn Gly Thr Thr  Val Ser Ser Pro Ser  Thr Ser Leu 
    3605                 3610                 3615             

Gln Arg  Ser Asp Ser Ser Gln  Pro Met Leu Leu Arg  Val Val Gly 
    3620                 3625                 3630             

Ser Gln  Thr Ser Asp Ser Met  Gly Glu Glu Asp Leu  Leu Ser Pro 
    3635                 3640                 3645             

Pro Gln  Asp Thr Ser Thr Gly  Leu Glu Glu Val Met  Glu Gln Leu 
    3650                 3655                 3660             

Asn Asn  Ser Phe Pro Ser Ser  Arg Gly Arg Asn Thr  Pro Gly Lys 
    3665                 3670                 3675             

Pro Met  Arg Glu Asp Thr Met  
    3680                 3685 


<210>  7
<211>  13857
<212>  DNA
<213>  mus musculus


<220>
<221>  misc_feature
<223>  mRNA sequence of the murine dystrophin gene DMD transcript

<400>  7
atcagttact atgttgactc actcagtgtt gggctcactc acttgcccct tacaggactc     60

agctcttgaa ggcaatagcc tttatagaaa aaacgaatag gaagacttga agtgctattt    120

ttttttttgt caaggctgct gaagtttatt ggcttctcat cgtacctaag cctcctggag    180

caataaaact gggagaaact tttaccaaga tttttatccc tgccttgata tatacttttt    240

cttccaaatg ctttggtggg aagaagtaga ggactgttat gaaagagaag atgttcaaaa    300

gaaaacattc acaaaatgga taaatgcaca attttctaag tttggaaagc aacacataga    360

caacctcttc agtgacctgc aggatggaaa acgcctccta gacctcttgg aaggccttac    420

agggcaaaaa ctgccaaaag aaaagggatc tacaagagtt catgccctga acaatgtcaa    480

caaggcactg cgggtcttac agaaaaataa tgttgattta gtgaatatag gaagcactga    540

catagtggat ggaaatcata aactcactct tggtttgatt tggaatataa tcctccactg    600

gcaggtcaaa aatgtgatga aaactatcat ggctggattg cagcaaacca acagtgaaaa    660

gattcttctg agctgggttc gacagtcaac acgtaattat ccacaggtta acgtcatcaa    720

cttcacctct agctggtccg acgggttggc tttgaatgct cttatccata gtcacaggcc    780

cgacctgttt gattggaata gtgtggtttc acagcactca gccacccaaa gactggaaca    840

tgccttcaac attgcaaaat gccagttagg catagaaaaa cttcttgatc ctgaagatgt    900

tgctaccact tatccagaca agaagtccat cttaatgtac atcacatcac tctttcaagt    960

tttgccacaa caagtgagca ttgaagccat tcaagaagtg gaaatgttgc ccaggacatc   1020

ttcaaaagta actagagaag aacattttca attacatcac cagatgcatt actctcaaca   1080

gatcacagtc agtctagcac agggctatga acaaacttct tcatctccta agcctcgatt   1140

caagagttat gccttcacac aggctgctta tgttgccacc tctgattcca cacagagccc   1200

ctatccttca cagcatttgg aagctcccag agacaagtca cttgacagtt cattgatgga   1260

gacggaagta aatctggata gttaccaaac tgctttagaa gaagtacttt catggcttct   1320

ttctgccgag gatacattgc gagcacaagg agagatttca aatgatgttg aagaagtgaa   1380

agaacagttt catgctcatg agggattcat gatggatctg acatctcatc aaggacttgt   1440

tggtaatgtt ctacagttag gaagtcaact agttggaaaa gggaaattat cagaagatga   1500

agaagctgaa gtgcaagaac aaatgaatct cctaaattca agatgggaat gtctcagggt   1560

agctagcatg gaaaaacaaa gcaaattaca caaagttcta atggatctcc agaatcagaa   1620

attaaaagaa ctagatgact ggttaacaaa aactgaagag agaactaaga aaatggagga   1680

agagcccttt ggacctgatc ttgaagatct aaaatgccaa gtacaacaac ataaggtgct   1740

tcaagaagat ctagaacagg agcaggtcag ggtcaactcg ctcactcaca tggtagtagt   1800

ggttgatgaa tccagcggtg atcatgcaac agctgctttg gaagaacaac ttaaggtact   1860

gggagatcga tgggcaaata tctgcagatg gactgaagac cgctggattg ttttacaaga   1920

tattcttcta aaatggcagc attttactga agaacagtgc ctttttagta catggctttc   1980

agaaaaagaa gatgcaatga agaacattca gacaagtggc tttaaagatc aaaatgaaat   2040

gatgtcaagt cttcacaaaa tatctacttt aaaaatagat ctagaaaaga aaaagccaac   2100

catggaaaaa ctaagttcac tcaatcaaga tctactttcg gcactgaaaa ataagtcagt   2160

gactcaaaag atggaaatct ggatggaaaa ctttgcacaa cgttgggaca atttaaccca   2220

aaaacttgaa aagagttcag cacaaatttc acaggctgtc accaccactc aaccatccct   2280

aacacagaca actgtaatgg aaacggtaac tatggtgacc acaagggaac aaatcatggt   2340

aaaacatgcc caagaggaac ttccaccacc acctcctcaa aagaagaggc agataactgt   2400

ggattctgaa ctcaggaaaa ggttggatgt cgatataact gaacttcaca gttggattac   2460

tcgttcagaa gctgtattac agagttctga atttgcagtc tatcgaaaag aaggcaacat   2520

ctcagacttg caagaaaaag tcaatgccat agcacgagaa aaagcagaga agttcagaaa   2580

actgcaagat gccagcagat cagctcaggc cctggtggaa cagatggcaa atgagggtgt   2640

taatgctgaa agtatcagac aagcttcaga acaactgaac agccggtgga cagaattctg   2700

ccaattgctg agtgagagag ttaactggct agagtatcaa accaacatca ttacctttta   2760

taatcagcta caacaattgg aacagatgac aactactgcc gaaaacttgt tgaaaaccca   2820

gtctaccacc ctatcagagc caacagcaat taaaagccag ttaaaaattt gtaaggatga   2880

agtcaacaga ttgtcagctc ttcagcctca aattgagcaa ttaaaaattc agagtctaca   2940

actgaaagaa aagggacagg ggccaatgtt tctggatgca gactttgtgg cctttactaa   3000

tcattttaac cacatctttg atggtgtgag ggccaaagag aaagagctac agacaatttt   3060

tgacacttta ccaccaatgc gctatcagga gacaatgagt agcatcagga cgtggatcca   3120

gcagtcagaa agcaaactct ctgtacctta tcttagtgtt actgaatatg aaataatgga   3180

ggagagactc gggaaattac aggctctgca aagttctttg aaagagcaac aaaatggctt   3240

caactatctg agtgacactg tgaaggagat ggccaagaaa gcaccttcag aaatatgcca   3300

gaaatatctg tcagaatttg aagagattga ggggcactgg aagaaacttt cctcccagtt   3360

ggtggaaagc tgccaaaagc tagaagaaca tatgaataaa cttcgaaaat ttcagaatca   3420

cataaaaacc ttacagaaat ggatggctga agttgatgtt ttcctgaaag aggaatggcc   3480

tgccctgggg gatgctgaaa tcctgaaaaa acagctcaaa caatgcagac ttttagttgg   3540

tgatattcaa acaattcagc ccagtttaaa tagtgttaat gaaggtgggc agaagataaa   3600

gagtgaagct gaacttgagt ttgcatccag actggagaca gaacttagag agcttaacac   3660

tcagtgggat cacatatgcc gccaggtcta caccagaaag gaagccttaa aggcaggttt   3720

ggataaaacc gtaagcctcc aaaaagatct atcagagatg catgagtgga tgacacaagc   3780

tgaagaagaa tatctagaga gagattttga atataaaact ccagatgaat tacagactgc   3840

tgttgaagaa atgaagagag ctaaagaaga ggcactacaa aaagaaacta aagtgaaact   3900

ccttactgag actgtaaata gtgtaatagc tcacgctcca ccctcagcac aagaggcctt   3960

aaaaaaggaa cttgaaactc tgaccaccaa ctaccaatgg ctgtgcacca ggctgaatgg   4020

aaaatgcaaa actttggaag aagtttgggc atgttggcat gagttattgt catatttaga   4080

gaaagcaaac aagtggctca atgaagtaga attgaaactt aaaaccatgg aaaatgttcc   4140

tgcaggacct gaggaaatca ctgaagtgct agaatctctt gaaaatctga tgcatcattc   4200

agaggagaac ccaaatcaga ttcgtctatt ggcacagact cttacagatg gaggagtcat   4260

ggatgaactg atcaatgagg agcttgagac gtttaattct cgttggaggg aactacatga   4320

agaggctgtg aggaaacaaa agttgcttga acagagtatc cagtctgccc aggaaattga   4380

aaagtccttg cacttaattc aggagtcgct tgaattcatt gacaagcagt tggcagctta   4440

tatcactgac aaggtggatg cagctcaaat gcctcaggaa gcccagaaaa tccaatcaga   4500

tttgacaagt catgagataa gtttagaaga aatgaagaaa cataaccagg ggaaggatgc   4560

caaccaaagg gttctttcac aaattgatgt tgcacagaaa aaattacaag atgtctccat   4620

gaaatttcga ttattccaaa aaccagccaa ttttgaacaa cgtctagagg aaagtaagat   4680

gattttagat gaagtcaaga tgcatttgcc tgcattggaa accaagagtg ttgaacagga   4740

agtaattcag tcacaactaa gtcattgtgt gaacttgtat aaaagcctga gtgaagtcaa   4800

gtctgaagtg gaaatggtga ttaaaaccgg acgtcaaatt gtacagaaaa agcagacaga   4860

aaatcccaaa gagcttgatg aacgagtaac agctttgaaa ttgcattaca atgagttggg   4920

tgcgaaggta acagagagaa agcaacagtt ggagaaatgc ttgaagttgt cccgtaagat   4980

gagaaaggaa atgaatgtct taacagaatg gctggcagca acagatacag aattgacgaa   5040

gagatcagca gttgaaggaa tgccaagtaa tttggattct gaagttgcct ggggaaaggc   5100

tactcaaaaa gagattgaga aacagaaggc tcacttgaag agtgttacag aattaggaga   5160

gtctttgaaa atggtgttgg gcaagaaaga aaccttggta gaagataaac tgagtcttct   5220

gaacagtaac tggatagctg tcacctccag agtagaagaa tggctaaatc ttttgttgga   5280

ataccagaaa cacatggaaa cctttgatca gaacatagaa caaatcacaa agtggatcat   5340

tcatgcagat gaacttttag atgagtctga aaagaagaaa ccacaacaaa aggaagacat   5400

tcttaagcgt ttaaaggctg aaatgaatga catgcgccca aaggtggact ccacacgtga   5460

ccaagcagca aaattgatgg caaaccgcgg tgaccactgc aggaaagtag tagagcccca   5520

aatctctgag ctcaaccgtc gatttgcagc tatttctcac agaattaaga ctggaaaggc   5580

ctccattcct ttgaaggaat tggagcagtt taactcagat atacaaaaat tgcttgaacc   5640

actggaggct gaaattcagc agggggtgaa tctgaaagag gaagacttca ataaagatat   5700

gagtgaagac aatgagggta ctgtaaatga attgttgcaa agaggagaca acttacaaca   5760

aagaatcaca gatgagagaa agcgagagga aataaagata aaacagcagc tgttacagac   5820

aaaacataat gctctcaagg atttgaggtc tcaaagaaga aaaaaggccc tagaaatttc   5880

tcaccagtgg tatcagtaca agaggcaggc tgatgatctc ctgaaatgct tggatgaaat   5940

tgaaaaaaaa ttagccagcc tacctgaacc cagagatgaa agaaaattaa aggaaattga   6000

tcgtgaattg cagaagaaga aagaggagct gaatgcagtg cgcaggcaag ctgagggctt   6060

gtctgagaat ggggccgcaa tggcagtgga gccaactcag atccagctca gcaagcgctg   6120

gcggcaaatt gagagcaatt ttgctcagtt tcgaagactc aactttgcac aaattcacac   6180

tctccatgaa gaaactatgg tagtgacgac tgaagatatg cctttggatg tttcttatgt   6240

gccttctact tatttgaccg agatcagtca tatcttacaa gctctttcag aagttgatca   6300

tcttctaaat actcctgaac tctgtgctaa agattttgaa gatcttttta agcaagagga   6360

gtctcttaag aatataaaag acaatttgca acaaatctca ggtcggattg atattattca   6420

caagaagaag acagcagcct tgcaaagtgc cacctccatg gaaaaggtga aagtacagga   6480

agccgtggca cagatggatt tccaggggga aaaacttcat agaatgtaca aggaacgaca   6540

agggcgattc gacagatcag ttgaaaaatg gcgacacttt cattatgata tgaaggtatt   6600

taatcaatgg ctgaatgaag ttgaacagtt tttcaaaaag acacaaaatc ctgaaaactg   6660

ggaacatgct aaatacaaat ggtatcttaa ggaactccag gatggcattg ggcagcgtca   6720

agctgttgtc agaacactga atgcaactgg ggaagaaata attcaacagt cttcaaaaac   6780

agatgtcaat attctacaag aaaaattagg aagcttgagt ctgcggtggc acgacatctg   6840

caaagagctg gcagaaagga gaaagaggat tgaagaacaa aagaatgtct tgtcagaatt   6900

tcaaagagat ttaaatgaat ttgttttgtg gctggaagaa gcagataaca ttgctattac   6960

tccacttgga gatgagcagc agctaaaaga acaacttgaa caagtcaagt tactggcaga   7020

agagttgccc ctgcgccagg gaattctaaa acaattaaat gaaacaggag gagcagtact   7080

tgtaagtgct cccataaggc cagaagagca agataaactt gaaaagaagc tcaaacagac   7140

aaatctccag tggataaagg tctccagagc tttacctgag aaacaaggag agcttgaggt   7200

tcacttaaaa gattttaggc agcttgaaga gcagctggat cacctgcttc tgtggctctc   7260

tcctattaga aaccagttgg aaatttataa ccaaccaagt caggcaggac cgtttgacat   7320

aaaggagatt gaagtaacag ttcacggtaa acaagcggat gtggaaaggc ttttgtcgaa   7380

agggcagcat ttgtataagg aaaaaccaag cactcagcca gtgaagagga agttagaaga   7440

tctgaggtct gagtgggagg ctgtaaacca tttacttcgg gagctgagga caaagcagcc   7500

tgaccgtgcc cctggactga gcactactgg agcctctgcc agtcagactg ttactctagt   7560

gacacaatct gtggttacta aggaaactgt catctccaaa ctagaaatgc catcttcttt   7620

gctgttggag gtacctgcac tggcagactt caaccgagct tggacagaac ttacagactg   7680

gctgtctctg cttgatcgag ttataaaatc acagagagtg atggtgggtg atctggaaga   7740

catcaatgaa atgatcatca aacagaaggc aacactgcaa gatttggaac agagacgccc   7800

ccaattggaa gaactcatta ctgctgccca gaatttgaaa aacaaaacca gcaatcaaga   7860

agctagaaca atcattactg atcgaattga aagaattcag attcagtggg atgaggttca   7920

agaacagctg cagaacagga gacaacagtt gaatgaaatg ttaaaggatt caacacaatg   7980

gctggaagct aaggaagaag ccgaacaggt cataggacag gtcagaggca agcttgactc   8040

atggaaagaa ggtcctcaca cagtagatgc aatccaaaag aagatcacag aaaccaagca   8100

gttggccaaa gacctccgtc aacggcagat aagtgtagac gtggcaaatg atttggcact   8160

gaaacttctt cgggactatt ctgctgatga taccagaaaa gtacacatga taacagagaa   8220

tatcaatact tcttggggaa acattcataa aagagtaagt gagcaagagg ctgctttgga   8280

agaaactcat agattactgc agcagttccc tctggacctg gagaagtttc tttcctggat   8340

tacggaagca gaaacaactg ccaatgtcct acaggacgct tcccgtaagg agaagctcct   8400

agaagactcc aggggagtca gagagctgat gaaaccatgg caagatctcc aaggagaaat   8460

tgaaactcac acagatatct atcacaatct tgatgaaaat ggccaaaaaa tcctgagatc   8520

cctggaaggt tcggatgaag cacccctgtt acaaagacgt ttggataaca tgaatttcaa   8580

gtggagtgaa cttcagaaaa agtctctcaa cattaggtcc catttggaag caagttctga   8640

ccagtggaag cgtttgcatc tttctcttca ggaacttctt gtttggctac agctgaaaga   8700

tgatgaactg agccgtcagg cacccatcgg tggtgatttc ccagcagttc agaagcagaa   8760

tgatatacat agggccttca agagggaatt gaaaactaaa gaacctgtaa tcatgagtac   8820

tctggagact gtgagaatat ttctgacaga gcagcctttg gaaggactag agaaactcta   8880

ccaggagccc agagaactgc ctcctgaaga aagagctcag aatgtcactc ggctcctacg   8940

aaagcaggct gaagaggtca acgctgaatg ggacaaattg aacctgcgct cagctgattg   9000

gcagagaaaa atagatgaag ctcttgaaag actccaggaa cttcaggaag ctgccgatga   9060

actggacctc aagttgcgcc aagctgaggt gatcaaggga tcctggcagc cagtggggga   9120

tctcctcatt gactctctgc aagatcacct tgaaaaagtc aaggcacttc ggggagaaat   9180

tgcacctctt aaagagaatg tcaatcgtgt caatgacctt gcacatcagc tgaccacact   9240

gggcattcag ctctcacctt ataacctcag cactttggaa gatctgaata ccagatggag   9300

gcttctacag gtggctgtgg aggaccgtgt cagacagctg catgaagccc acagggactt   9360

tggtcctgca tcccagcact tcctttccac ttcagttcag ggtccctggg agagagccat   9420

ctcaccaaac aaagtgccct actatatcaa ccacgagacc caaaccactt gttgggacca   9480

ccccaaaatg acagagctct accagtcttt agctgacctg aataatgtca ggttctccgc   9540

gtataggact gccatgaagc tcagaaggct ccagaaggcc ctttgcttgg atctcttgag   9600

cctgtcagct gcatgtgatg ccctggacca gcacaacctc aagcaaaatg accagcccat   9660

ggatatcctg cagataatta actgtttgac tacaatttat gatcgtctgg agcaagagca   9720

caacaatctg gtcaatgtcc ctctctgtgt ggatatgtgt ctcaactggc ttctcaatgt   9780

ttatgatacg ggacgaacag ggaggatccg tgtcctgtct tttaaaactg gcatcatttc   9840

tctgtgtaaa gcacacttgg aagacaagta cagatacctt ttcaagcaag tggcaagttc   9900

aactggcttt tgtgaccagc gtaggctggg tcttcttctg catgattcta ttcaaatccc   9960

aagacagttg ggtgaagttg cttcctttgg gggcagtaac attgagccga gtgtcaggag  10020

ctgcttccaa tttgccaata ataaacctga gattgaagct gctctcttcc ttgactggat  10080

gcgcctggaa ccccagtcta tggtgtggct gcccgtcttg cacagagtgg ctgctgctga  10140

aactgccaag catcaagcca agtgtaacat ctgtaaggag tgtccaatca ttggattcag  10200

gtacagaagc ctaaagcatt ttaattatga catctgccaa agttgctttt tttctggccg  10260

agttgcaaag ggccataaaa tgcactaccc catggtagag tattgcactc cgactacatc  10320

cggagaagat gttcgcgact tcgccaaggt actaaaaaac aaatttcgaa ccaaaaggta  10380

ttttgcgaag catccccgaa tgggctacct gccagtgcag actgtgttag agggggacaa  10440

catggaaact cccgttactc tgatcaactt ctggccagta gattctgcgc ctgcctcgtc  10500

cccccagctt tcacacgatg atactcattc acgcattgaa cattatgcta gcaggctagc  10560

agaaatggaa aacagcaatg gatcttatct aaatgatagc atctctccta atgagagcat  10620

agatgatgaa catttgttaa tccagcatta ctgccaaagt ttgaaccagg actcccccct  10680

gagccagcct cgtagtcctg cccagatctt gatttcctta gagagtgagg aaagagggga  10740

gctagagaga atcctagcag atcttgagga agaaaacagg aatctgcaag cagaatatga  10800

tcgcctgaag cagcagcatg agcataaagg cctgtctcca ctgccatctc ctcctgagat  10860

gatgcccacc tctcctcaga gtcccaggga tgctgagctc attgctgagg ctaagctact  10920

gcgccaacac aaaggacgcc tggaagccag gatgcaaatc ctggaagacc acaataaaca  10980

gctggagtct cagttacata gactgagaca gctcctggag cagccccagg ctgaagctaa  11040

ggtgaatggc accacggtgt cctctccttc cacctctctg cagaggtcag atagcagtca  11100

gcctatgctg ctccgagtgg ttggcagtca aacttcagaa tctatgggtg aggaagatct  11160

tctgagtcct ccccaggaca caagcacagg gttagaagaa gtgatggagc aactcaacaa  11220

ctccttccct agttcaagag gaagaaatgc ccccggaaag ccaatgagag aggacacaat  11280

gtaggaagcc ttttccacat ggcagatgat ttgggcagag cgatggagtc cttagtttca  11340

gtcatgacag atgaagaagg agcagaataa atgttttaca actcctgatt cccgcatggt  11400

ttttataata ttcgtacaac aaagaggatt agacagtaag agtttacaag aaataaaatc  11460

tatatttttg tgaagggtag tggtactata ctgtagattt cagtagtttc taagtctgtt  11520

attgttttgt taacaatggc aggttttaca cgtctatgca attgtacaaa aaagttaaaa  11580

gaaaacatgt aaaatcttga tagctaaata acttgccatt tctttatatg gaacgcattt  11640

tgggttgttt aaaaatttat aacagttata aagaaagatt gtaaactaaa gtgtgcttta  11700

taaaaaaagt tgtttataaa aacccctaaa caaacacaca cgcacacaca cacacacaca  11760

cacacacaca cacacacgca cacatacatg cacgaaccca ccacacacac acacacacac  11820

acacacactg aggcagcaca ttgttttgca ttactttagc gtggtattca tatggaattc  11880

atgacgtttt tttattttct tgcatacgaa ccccaccaaa tgactgcttc atattgctct  11940

tttgagaatt gttgactgag tggggctggc tatgggcttt cattttatac atctatatgt  12000

ctacaagtat ataaatacta taggtatata gataaataga tatgaagtta cttcttcaaa  12060

tgttcttgcc acttcctaat ggaaattgct tctagtcatc tgggcttatc tgcttgggca  12120

agagtgaatt ttccctggag cccaaagcca ggagactacc gccacactaa aatattgtct  12180

agggctccag atgtttctag ttttaaactt tccactgaga gctagaggat tcattttttt  12240

caaggaacat gcgaatgaat acacaggact tactatcata gtaatttgtt ggctgatata  12300

ttcaacttcc tactgttggg ttatatttaa tgatgtttct gcaatagaac atcagatgac  12360

atttttaact cccagacagt aggaggaaga tggtaggagc taaaggttgc ggctcctcag  12420

tcaatttata tgaggggagc aacaactctg taaaagaatg gatgaatatt tacaactata  12480

catataaaca tctctataat tacaactaaa ttgttctgcc ctcttcataa actcaacctg  12540

aagtgggtgg ttttgttgtt gttgttgttg ttgttgttga tgatgatgat gaattttaga  12600

ttttagattt tttgggtttt tttttcttca ttgtgatgat tttttttttt aatgctgcaa  12660

gacttaggat tactgttaag aaagtaaccc aatcacattg tgaccctggt gaatatcagt  12720

ccagaagccc atgaactgca tttgtctcct ttgcattggt ttccctgcaa gtaactccac  12780

acaggattgt gggtgagaag gcacagtggt tggaaagttt tgagagcaaa agcgtctcca  12840

aactctctgg tctagttgac gggctgaaat gtctaaacaa atgcaagtca ttgaaccagg  12900

agaaaaagtg caacagaaag ctaaggactg ctaggaagag ctttactcct ctcatgccag  12960

tttcttcttc ttagcattta aagagcattc tctcaataga aatcactgtc ctatcatttt  13020

gcaaatctgt tacctctaac gtcaagtgta attaacttct agcgagtggg ttttgtccat  13080

tattaattgt aattaacatc aaacacagct tctcatgcta tttctacctc actttggttt  13140

tggggtgttt ctagtaattg tgcacaccta atttcacaac ttcaccactt gtctgttgtg  13200

tggacaccag tttccttttt tcatttataa tttccaaaag aaaacccaaa gctctaagat  13260

aacaaattga aatttggttc tggtcttgct ttctctctct ctctctcctt tatgtggcac  13320

tgggcatttt ctttatccaa ggatttgttt tcaccaagat ttaaaacaag gggttccttt  13380

cctactaaga agttttaagt ttcattctaa aatccaaggt agatagagtg catagttttg  13440

ttttaatctt ttcgttttat cttttagata ttagttctgg agtgaatcta tcaaaatatt  13500

tgaataaaaa ctgagagctt tattgctgat tttaagcata atttggacat catttcatgt  13560

tctttataac catcaagtat taaagtgtaa atcataatca gtgtaactga agcataatca  13620

tcacatggca tgtatcatca ttgtctccag gtactggact cttacttgag tatcataata  13680

gattgtgttt taacaccaac actgtaacat ttactaatta tttttttaaa cttcagtttt  13740

actgcatttt cacaacatat cagatttcac caaatatatg ccttactatt gtattatatt  13800

actgctttac tgtgtatctc aataaagcac gcagttatgt tacaaaaaaa taaaaaa     13857


<210>  8
<211>  213
<212>  DNA
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Nucleotide sequence of the murine dystrophin gene DMD, exon 23

<400>  8
gctctgcaaa gttctttgaa agagcaacaa aatggcttca actatctgag tgacactgtg     60

aaggagatgg ccaagaaagc accttcagaa atatgccaga aatatctgtc agaatttgaa    120

gagattgagg ggcactggaa gaaactttcc tcccagttgg tggaaagctg ccaaaagcta    180

gaagaacata tgaataaact tcgaaaattt cag                                 213


<210>  9
<211>  213
<212>  DNA
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Nucleotide sequence of the mutated dystrophin gene DMD from the 
       mdx mouse, exon 23

<400>  9
gctctgcaaa gttctttgaa agagcaataa aatggcttca actatctgag tgacactgtg     60

aaggagatgg ccaagaaagc accttcagaa atatgccaga aatatctgtc agaatttgaa    120

gagattgagg ggcactggaa gaaactttcc tcccagttgg tggaaagctg ccaaaagcta    180

gaagaacata tgaataaact tcgaaaattt cag                                 213


<210>  10
<211>  114
<212>  DNA
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Nucleotide sequence of the murine dystrophin gene DMD, exon 24

<400>  10
aatcacataa aaaccttaca gaaatggatg gctgaagttg atgttttcct gaaagaggaa     60

tggcctgccc tgggggatgc tgaaatcctg aaaaaacagc tcaaacaatg caga          114


<210>  11
<211>  913
<212>  DNA
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Nucleotide sequence of the murine dystrophin gene DMD, intron 22

<400>  11
gtctgtggac atttgaatat cataaataac aaagaacatg tcttatcagt caagagatca     60

tattgatata ttaaacttaa ggtaataatg aaaaagtaaa gataataatg aaaaatcata    120

gattatgagt tggaaaaata aacagaacaa tttgaccaaa aacatgactt tttcttattt    180

ttttctatat attattttat aaatatacag acataaatag atatatattt ttaaattaaa    240

agtactgtat taaaggaaag gtataatttc atttcatatt tagtgacata agatatgaag    300

tatgattatt aaaattaaat cacattattt tattataatt actttatttt taattcctaa    360

tttctttaag cttaggtaaa atcaatggat ttatataatt agttagaatt taaatattaa    420

caaactataa cactatgatt aaatgcttga tattgagtag ttattttaat agcctaagtc    480

tggaaattaa atactagtaa gagaaacttc tgtgatgtga ggacatataa agactaattt    540

ttttgttgat tctaaaaatc ccatgttgta tacttattct ttttaaatct gaaaatatat    600

taatcatata ttgcctaaat gtcttaataa tgtttcactg taggtaagtt aaaatgtatc    660

acatatataa taaacatagt tattaatgca tagatattca gtaaaattat gacttctaaa    720

tttctgtcta aatataatat gccctgtaat ataatagaaa ttattcataa gaatacatat    780

atattgcttt atcagatatt ctactttgtt tagatctcta aattacataa acttttattt    840

accttcttct tgatatgaat gaaactcatc aaatatgcgt gttagtgtaa atgaacttct    900

atttaatttt gag                                                       913


<210>  12
<211>  2607
<212>  DNA
<213>  mus musculus


<220>
<221>  misc_feature
<223>  Nucleotide sequence of the murine dystrophin gene DMD, intron 23

<400>  12
gtaagccgag gtttggcctt taaactatat tttttcacat agcaattaat tggaaaatgt     60

gatgggaaac agatatttta cccagagtcc ttcaaagata ttgatgatat caaaagccaa    120

atctatttca aaggattgca acttgcctat ttttcctatg aaaacagtaa tgtgtcatac    180

cttcttggat tgtctgtata aatgaattga ttttttttca ccaactccaa gtatacttaa    240

cattttaaca taataattta aaatatcctt attccattat gttcattttt taagttgtag    300

atatgattta gctcacagca tacatatata cacatgtatt acatatgcat atattatata    360

tatggcagac atatgttttc actaccatat ttcacttttg aattatgaat atatgtttaa    420

tttctgccat atttccttcc ctacattgac ttctattaat ttagtatttc agtagttcta    480

acacattaat aataacctag actcaataca gtaatctaac aattatattt gtgcctgtaa    540

ttctaagtta gttaaattca taggttgtgt ttctcatagt tggccatttg tgaaatataa    600

taatatccga aaagaaagtt caaaaatgtc atgacttcat atagagttat tgaaacagtg    660

cccttacttt cattctggcc atgctagtga cttgatcatt cttgtatttt acagctaaaa    720

cactaccaaa agtgtcaaat ccatgatcta catgtttgac tgaggctagc agcacttatt    780

ccacccttat atgaagcctt taagagaaag tatatttgtt tgctattttt aacttcttga    840

aggaacatac aatctttgtt tcaagagctc atcctctttc atgctagtaa attttggtgg    900

cattgcatcc atgtctgact ctgaatctgt ttctgtctat cctgctccct aacactgtac    960

catcttcctt tttgaaaaaa aaatattgaa ttattttatt tatttacttt ccaaagttgc   1020

tcctgcctgt tcctccttct ccaagttctt cagtcccccc tgctccccac cgatgagagg   1080

gaaaggtcct gaattcactg ggctccatgg gggtcctttt gcattttctt aaccttctta   1140

ataaaatagg ccttctagaa ttatatcata tacattgtga tatgacaaat gataaagtat   1200

attgttcaga gttttacctt gttcatattt gcaatgtccc cctgtcatgc tggatattct   1260

ttgattgggt atatttgcta acagattaag tatatttatc ttcgttaagc agtataactt   1320

attaagaaag aactctatta atatgagaaa taactaatga aacaccactc cacaggtgat   1380

ttcagccact ttatgaactg ctggaagcaa aaatgagatc tttgcaacat gaagcagttg   1440

ctcagttcat taaactgtgt tcaatatttc agccataaca tacattagag aatgatttat   1500

attgttcaaa catttggtgc tctatttttg catgacgtgg gattaaacac agcaccaaca   1560

atcaaacaat tgcaaagatg tattacaagt attttttctt tttaaaacag gaaagtatac   1620

ttatatttcc attgtccaaa ccatcatgaa agggatagag attactgaca caaatttaga   1680

gaaaggattt gagtggagta agaattaaat gaaccaaaga agaattaatg tattcatcaa   1740

gaagtcatgg aggtgaaatt ggccttgaat gataccacta aggagagaat gttgagatcc   1800

ttatatttag tcaattgttt ttaaatctgt agttattaac cacattttaa tcatattgaa   1860

agggaaattt tctgtgatgc atgtattttc aatataaatt ttagaaaaga agacaattat   1920

aacttgattt tgtgaattac atggaactaa agaaatgaca gatttacatt tgaaaattga   1980

ctgaactaaa gtacataaat aaaagtcata cagaaaaatg tgggaggtgc ttgtccattt   2040

ataaaggaca aaaatgccat ttgttgccta atcattattt cttattggtc agaccaataa   2100

gaaatcaaga gctttgactt taaaggtaag aaaatcttac cttaaaatcc ccaactgaag   2160

ggactgttta aactgtcaac tgcagaaaac aagttatgga agttcaggtt tagggaaact   2220

ataaacacac cataacattg agtttatgtg catagtttgt tttatgtaca gtgagagtaa   2280

attgttagta ttatcatgag ttgttttgaa acttcaaatt tctctagagg ggtatgattt   2340

aatgttctca agaggaacat aataaaacca tatctggtat tagtttttat ttttaacaat   2400

agcagacttc atacaccaat gttcacagtg tagaccataa aatgcagtct tagtaaaaat   2460

attattctct ataaagctac aatgagacct ccctcaaaca tacattgttt ttttttttct   2520

aacttatgtt tggatatatc atcatgatga actatgttaa aaacaatcag agcttagtaa   2580

tactttcata ttgctttttt attccag                                       2607


<210>  13
<211>  150
<212>  DNA
<213>  artificial

<220>
<223>  Antisense sequence AS1

<400>  13
cttcatatct tatgtcacta aatatgaaat gaaattatac ctttccttta atacagtact     60

tttaatttaa aaatatatat ctatttatgt ctgtatattt ataaaataat atatagaaaa    120

aaataagaaa aagtcatgtt tttggtcaaa                                     150


<210>  14
<211>  150
<212>  DNA
<213>  artificial

<220>
<223>  Antisense sequence AS2

<400>  14
atatattttc agatttaaaa agaataagta tacaacatgg gatttttaga atcaacaaaa     60

aaattagtct ttatatgtcc tcacatcaca gaagtttctc ttactagtat ttaatttcca    120

gacttaggct attaaaataa ctactcaata                                     150


<210>  15
<211>  150
<212>  DNA
<213>  artificial

<220>
<223>  Antisense sequence AS3

<400>  15
aaatagaagt tcatttacac taacacgcat atttgatgag tttcattcat atcaagaaga     60

aggtaaataa aagtttatgt aatttagaga tctaaacaaa gtagaatatc tgataaagca    120

atatatatgt attcttatga ataatttcta                                     150


<210>  16
<211>  150
<212>  DNA
<213>  artificial

<220>
<223>  Antisense sequence AS4

<400>  16
ttagttccat gtaattcaca aaatcaagtt ataattgtct tcttttctaa aatttatatt     60

gaaaatacat gcatcacaga aaatttccct ttcaatatga ttaaaatgtg gttaataact    120

acagatttaa aaacaattga ctaaatataa                                     150


<210>  17
<211>  150
<212>  DNA
<213>  artificial

<220>
<223>  Antisense sequence AS5

<400>  17
cacataaact caatgttatg gtgtgtttat agtttcccta aacctgaact tccataactt     60

gttttctgca gttgacagtt taaacagtcc cttcagttgg ggattttaag gtaagatttt    120

cttaccttta aagtcaaagc tcttgatttc                                     150


<210>  18
<211>  150
<212>  DNA
<213>  artificial

<220>
<223>  Antisense sequence AS6

<400>  18
tcatcatgat gatatatcca aacataagtt agaaaaaaaa aaacaatgta tgtttgaggg     60

aggtctcatt gtagctttat agagaataat atttttacta agactgcatt ttatggtcta    120

cactgtgaac attggtgtat gaagtctgct                                     150


<210>  19
<211>  150
<212>  DNA
<213>  artificial

<220>
<223>  Antisense sequence AS7

<400>  19
caagttgcaa tcctttgaaa tagatttggc ttttgatatc atcaatatct ttgaaggact     60

ctgggtaaaa tatctgtttc ccatcacatt ttccaattaa ttgctatgtg aaaaaatata    120

gtttaaaggc caaacctcgg cttacctgaa                                     150


<210>  20
<211>  150
<212>  DNA
<213>  artificial

<220>
<223>  Antisense sequence AS8

<400>  20
ctacaactta aaaaatgaac ataatggaat aaggatattt taaattatta tgttaaaatg     60

ttaagtatac ttggagttgg tgaaaaaaaa tcaattcatt tatacagaca atccaagaag    120

gtatgacaca ttactgtttt cataggaaaa                                     150


<210>  21
<211>  306
<212>  DNA
<213>  artificial

<220>
<223>  Antisense sequence 2XAS4

<400>  21
ttagttccat gtaattcaca aaatcaagtt ataattgtct tcttttctaa aatttatatt     60

gaaaatacat gcatcacaga aaatttccct ttcaatatga ttaaaatgtg gttaataact    120

acagatttaa aaacaattga ctaaatataa gaattcttag ttccatgtaa ttcacaaaat    180

caagttataa ttgtcttctt ttctaaaatt tatattgaaa atacatgcat cacagaaaat    240

ttccctttca atatgattaa aatgtggtta ataactacag atttaaaaac aattgactaa    300

atataa                                                               306


<210>  22
<211>  2250
<212>  DNA
<213>  artificial

<220>
<223>  Nucleotide sequence located in the 5'-half of the nucleotide 
       sequence of intron 23

<400>  22
gtaagccgag gtttggcctt taaactatat tttttcacat agcaattaat tggaaaatgt     60

gatgggaaac agatatttta cccagagtcc ttcaaagata ttgatgatat caaaagccaa    120

atctatttca aaggattgca acttgcctat ttttcctatg aaaacagtaa tgtgtcatac    180

cttcttggat tgtctgtata aatgaattga ttttttttca ccaactccaa gtatacttaa    240

cattttaaca taataattta aaatatcctt attccattat gttcattttt taagttgtag    300

atatgattta gctcacagca tacatatata cacatgtatt acatatgcat atattatata    360

tatggcagac atatgttttc actaccatat ttcacttttg aattatgaat atatgtttaa    420

tttctgccat atttccttcc ctacattgac ttctattaat ttagtatttc agtagttcta    480

acacattaat aataacctag actcaataca gtaatctaac aattatattt gtgcctgtaa    540

ttctaagtta gttaaattca taggttgtgt ttctcatagt tggccatttg tgaaatataa    600

taatatccga aaagaaagtt caaaaatgtc atgacttcat atagagttat tgaaacagtg    660

cccttacttt cattctggcc atgctagtga cttgatcatt cttgtatttt acagctaaaa    720

cactaccaaa agtgtcaaat ccatgatcta catgtttgac tgaggctagc agcacttatt    780

ccacccttat atgaagcctt taagagaaag tatatttgtt tgctattttt aacttcttga    840

aggaacatac aatctttgtt tcaagagctc atcctctttc atgctagtaa attttggtgg    900

cattgcatcc atgtctgact ctgaatctgt ttctgtctat cctgctccct aacactgtac    960

catcttcctt tttgaaaaaa aaatattgaa ttattttatt tatttacttt ccaaagttgc   1020

tcctgcctgt tcctccttct ccaagttctt cagtcccccc tgctccccac cgatgagagg   1080

gaaaggtcct gaattcactg ggctccatgg gggtcctttt gcattttctt aaccttctta   1140

ataaaatagg ccttctagaa ttatatcata tacattgtga tatgacaaat gataaagtat   1200

attgttcaga gttttacctt gttcatattt gcaatgtccc cctgtcatgc tggatattct   1260

ttgattgggt atatttgcta acagattaag tatatttatc ttcgttaagc agtataactt   1320

attaagaaag aactctatta atatgagaaa taactaatga aacaccactc cacaggtgat   1380

ttcagccact ttatgaactg ctggaagcaa aaatgagatc tttgcaacat gaagcagttg   1440

ctcagttcat taaactgtgt tcaatatttc agccataaca tacattagag aatgatttat   1500

attgttcaaa catttggtgc tctatttttg catgacgtgg gattaaacac agcaccaaca   1560

atcaaacaat tgcaaagatg tattacaagt attttttctt tttaaaacag gaaagtatac   1620

ttatatttcc attgtccaaa ccatcatgaa agggatagag attactgaca caaatttaga   1680

gaaaggattt gagtggagta agaattaaat gaaccaaaga agaattaatg tattcatcaa   1740

gaagtcatgg aggtgaaatt ggccttgaat gataccacta aggagagaat gttgagatcc   1800

ttatatttag tcaattgttt ttaaatctgt agttattaac cacattttaa tcatattgaa   1860

agggaaattt tctgtgatgc atgtattttc aatataaatt ttagaaaaga agacaattat   1920

aacttgattt tgtgaattac atggaactaa agaaatgaca gatttacatt tgaaaattga   1980

ctgaactaaa gtacataaat aaaagtcata cagaaaaatg tgggaggtgc ttgtccattt   2040

ataaaggaca aaaatgccat ttgttgccta atcattattt cttattggtc agaccaataa   2100

gaaatcaaga gctttgactt taaaggtaag aaaatcttac cttaaaatcc ccaactgaag   2160

ggactgttta aactgtcaac tgcagaaaac aagttatgga agttcaggtt tagggaaact   2220

ataaacacac cataacattg agtttatgtg                                    2250


<210>  23
<211>  34
<212>  DNA
<213>  artificial

<220>
<223>  Spacer 1 (3' end)

<400>  23
acagctcttt ctttccatgg gttggcctga attc                                 34


<210>  24
<211>  42
<212>  DNA
<213>  artificial

<220>
<223>  Spacer 2 (5'-end)

<400>  24
ctcgagagat ctccgcggaa cattattata acgttgctcg aa                        42


<210>  25
<211>  7
<212>  DNA
<213>  artificial

<220>
<223>  Conserved yeast branch point sequence

<400>  25
tactaac                                                                7


<210>  26
<211>  30
<212>  DNA
<213>  artificial

<220>
<223>  Intronic Splice Enhancer (ISE) sequence

<400>  26
ggctgaggga aggactgtcc tggggactgg                                      30


<210>  27
<211>  24
<212>  DNA
<213>  artificial

<220>
<223>  Downstream Intronic Splice Enhancer (DISE) sequence

<400>  27
ctctttcttt ccatgggttg gcct                                            24


<210>  28
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  Polypyrimidine tract sequence

<400>  28
tctcttcttt ttttttttcc                                                 20


<210>  29
<211>  9
<212>  DNA
<213>  artificial

<220>
<223>  Canonical 3' acceptor splice site

<400>  29
ggaaaacag                                                              9


<210>  30
<211>  6
<212>  DNA
<213>  artificial

<220>
<223>  5' donor splice site

<400>  30
gtaaga                                                                 6


<210>  31
<211>  41
<212>  DNA
<213>  artificial

<220>
<223>  3' splice region of the Pre-Trans-Splicing molecule gene

<400>  31
tactaactga tatctcttct tttttttttt ccggaaaaca g                         41


<210>  32
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Forward primer for E23

<400>  32
agatggccaa gaaagcacc                                                  19


<210>  33
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Reverse primer for E23

<400>  33
ctttccacca actgggagg                                                  19


<210>  34
<211>  23
<212>  DNA
<213>  artificial

<220>
<223>  Forward primer for E24

<400>  34
tgaaaaaaca gctcaaacaa tgc                                             23


<210>  35
<211>  19
<212>  DNA
<213>  artificial

<220>
<223>  Reverse primer for E24

<400>  35
agcatccccc agggcaggc                                                  19


<210>  36
<211>  21
<212>  DNA
<213>  artificial

<220>
<223>  Forward primer E22-F

<400>  36
gacactttac caccaatgcg c                                               21


<210>  37
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  Reverse primer pSMD2-R1

<400>  37
ctttctgata ggcagcctgc                                                 20


<210>  38
<211>  20
<212>  DNA
<213>  artificial

<220>
<223>  Primer pSMD2-R5

<400>  38
ctcaccctga agttctcagg                                                 20


<210>  39
<211>  3996
<212>  DNA
<213>  artificial

<220>
<223>  The murine DMD minigene target comprising exons E22, E23, and E24

<400>  39
tttttgacac tttaccacca atgcgctatc aggagacaat gagtagcatc aggacgtgga     60

tccagcagtc agaaagcaaa ctctctgtac cttatcttag tgttactgaa tatgaaataa    120

tggaggagag actcgggaaa ttacaggtct gtggacattt gaatatcata aataacaaag    180

aacatgtctt atcagtcaag agatcatatt gatatattaa acttaaggta ataatgaaaa    240

agtaaagata ataatgaaaa atcatagatt atgagttgga aaaataaaca gaacaatttg    300

accaaaaaca tgactttttc ttattttttt ctatatatta ttttataaat atacagacat    360

aaatagatat atatttttaa attaaaagta ctgtattaaa ggaaaggtat aatttcattt    420

catatttagt gacataagat atgaagtatg attattaaaa ttaaatcaca ttattttatt    480

ataattactt tatttttaat tcctaatttc tttaagctta ggtaaaatca atggatttat    540

ataattagtt agaatttaaa tattaacaaa ctataacact atgattaaat gcttgatatt    600

gagtagttat tttaatagcc taagtctgga aattaaatac tagtaagaga aacttctgtg    660

atgtgaggac atataaagac taattttttt gttgattcta aaaatcccat gttgtatact    720

tattcttttt aaatctgaaa atatattaat catatattgc ctaaatgtct taataatgtt    780

tcactgtagg taagttaaaa tgtatcacat atataataaa catagttatt aatgcataga    840

tattcagtaa aattatgact tctaaatttc tgtctaaata taatatgccc tgtaatataa    900

tagaaattat tcataagaat acatatatat tgctttatca gatattctac tttgtttaga    960

tctctaaatt acataaactt ttatttacct tcttcttgat atgaatgaaa ctcatcaaat   1020

atgcgtgtta gtgtaaatga acttctattt aattttgagg ctctgcaaag ttctttgaaa   1080

gagcaataaa atggcttcaa ctatctgagt gacactgtga aggagatggc caagaaagca   1140

ccttcagaaa tatgccagaa atatctgtca gaatttgaag agattgaggg gcactggaag   1200

aaactttcct cccagttggt ggaaagctgc caaaagctag aagaacatat gaataaactt   1260

cgaaaatttc aggtaagccg aggtttggcc tttaaactat attttttcac atagcaatta   1320

attggaaaat gtgatgggaa acagatattt tacccagagt ccttcaaaga tattgatgat   1380

atcaaaagcc aaatctattt caaaggattg caacttgcct atttttccta tgaaaacagt   1440

aatgtgtcat accttcttgg attgtctgta taaatgaatt gatttttttt caccaactcc   1500

aagtatactt aacattttaa cataataatt taaaatatcc ttattccatt atgttcattt   1560

tttaagttgt agatatgatt tagctcacag catacatata tacacatgta ttacatatgc   1620

atatattata tatatggcag acatatgttt tcactaccat atttcacttt tgaattatga   1680

atatatgttt aatttctgcc atatttcctt ccctacattg acttctatta atttagtatt   1740

tcagtagttc taacacatta ataataacct agactcaata cagtaatcta acaattatat   1800

ttgtgcctgt aattctaagt tagttaaatt cataggttgt gtttctcata gttggccatt   1860

tgtgaaatat aataatatcc gaaaagaaag ttcaaaaatg tcatgacttc atatagagtt   1920

attgaaacag tgcccttact ttcattctgg ccatgctagt gacttgatca ttcttgtatt   1980

ttacagctaa aacactacca aaagtgtcaa atccatgatc tacatgtttg actgaggcta   2040

gcagcactta ttccaccctt atatgaagcc tttaagagaa agtatatttg tttgctattt   2100

ttaacttctt gaaggaacat acaatctttg tttcaagagc tcatcctctt tcatgctagt   2160

aaattttggt ggcattgcat ccatgtctga ctctgaatct gtttctgtct atcctgctcc   2220

ctaacactgt accatcttcc tttttgaaaa aaaaatattg aattatttta tttatttact   2280

ttccaaagtt gctcctgcct gttcctcctt ctccaagttc ttcagtcccc cctgctcccc   2340

accgatgaga gggaaaggtc ctgaattcac tgggctccat gggggtcctt ttgcattttc   2400

ttaaccttct taataaaata ggccttctag aattatatca tatacattgt gatatgacaa   2460

atgataaagt atattgttca gagttttacc ttgttcatat ttgcaatgtc cccctgtcat   2520

gctggatatt ctttgattgg gtatatttgc taacagatta agtatattta tcttcgttaa   2580

gcagtataac ttattaagaa agaactctat taatatgaga aataactaat gaaacaccac   2640

tccacaggtg atttcagcca ctttatgaac tgctggaagc aaaaatgaga tctttgcaac   2700

atgaagcagt tgctcagttc attaaactgt gttcaatatt tcagccataa catacattag   2760

agaatgattt atattgttca aacatttggt gctctatttt tgcatgacgt gggattaaac   2820

acagcaccaa caatcaaaca attgcaaaga tgtattacaa gtattttttc tttttaaaac   2880

aggaaagtat acttatattt ccattgtcca aaccatcatg aaagggatag agattactga   2940

cacaaattta gagaaaggat ttgagtggag taagaattaa atgaaccaaa gaagaattaa   3000

tgtattcatc aagaagtcat ggaggtgaaa ttggccttga atgataccac taaggagaga   3060

atgttgagat ccttatattt agtcaattgt ttttaaatct gtagttatta accacatttt   3120

aatcatattg aaagggaaat tttctgtgat gcatgtattt tcaatataaa ttttagaaaa   3180

gaagacaatt ataacttgat tttgtgaatt acatggaact aaagaaatga cagatttaca   3240

tttgaaaatt gactgaacta aagtacataa ataaaagtca tacagaaaaa tgtgggaggt   3300

gcttgtccat ttataaagga caaaaatgcc atttgttgcc taatcattat ttcttattgg   3360

tcagaccaat aagaaatcaa gagctttgac tttaaaggta agaaaatctt accttaaaat   3420

ccccaactga agggactgtt taaactgtca actgcagaaa acaagttatg gaagttcagg   3480

tttagggaaa ctataaacac accataacat tgagtttatg tgcatagttt gttttatgta   3540

cagtgagagt aaattgttag tattatcatg agttgttttg aaacttcaaa tttctctaga   3600

ggggtatgat ttaatgttct caagaggaac ataataaaac catatctggt attagttttt   3660

atttttaaca atagcagact tcatacacca atgttcacag tgtagaccat aaaatgcagt   3720

cttagtaaaa atattattct ctataaagct acaatgagac ctccctcaaa catacattgt   3780

tttttttttt ctaacttatg tttggatata tcatcatgat gaactatgtt aaaaacaatc   3840

agagcttagt aatactttca tattgctttt ttattccaga atcacataaa aaccttacag   3900

aaatggatgg ctgaagttga tgttttcctg aaagaggaat ggcctgccct gggggatgct   3960

gaaatcctga aaaaacagct caaacaatgc agataa                             3996


<210>  40
<211>  347
<212>  DNA
<213>  artificial

<220>
<223>  TS molecules AS1-E24

<400>  40
cttcatatct tatgtcacta aatatgaaat gaaattatac ctttccttta atacagtact     60

tttaatttaa aaatatatat ctatttatgt ctgtatattt ataaaataat atatagaaaa    120

aaataagaaa aagtcatgtt tttggtcaaa ctcgagagat ctccgcggaa cattattata    180

acgttgctcg aatactaact gatatctctt cttttttttt ttccggaaaa cagaatcaca    240

taaaaacctt acagaaatgg atggctgaag ttgatgtttt cctgaaagag gaatggcctg    300

ccctggggga tgctgaaatc ctgaaaaaac agctcaaaca atgcaga                  347


<210>  41
<211>  347
<212>  DNA
<213>  artificial

<220>
<223>  TS molecule AS2-E24

<400>  41
atatattttc agatttaaaa agaataagta tacaacatgg gatttttaga atcaacaaaa     60

aaattagtct ttatatgtcc tcacatcaca gaagtttctc ttactagtat ttaatttcca    120

gacttaggct attaaaataa ctactcaata ctcgagagat ctccgcggaa cattattata    180

acgttgctcg aatactaact gatatctctt cttttttttt ttccggaaaa cagaatcaca    240

taaaaacctt acagaaatgg atggctgaag ttgatgtttt cctgaaagag gaatggcctg    300

ccctggggga tgctgaaatc ctgaaaaaac agctcaaaca atgcaga                  347


<210>  42
<211>  347
<212>  DNA
<213>  artificial

<220>
<223>  TS molecule AS3-E24

<400>  42
aaatagaagt tcatttacac taacacgcat atttgatgag tttcattcat atcaagaaga     60

aggtaaataa aagtttatgt aatttagaga tctaaacaaa gtagaatatc tgataaagca    120

atatatatgt attcttatga ataatttcta ctcgagagat ctccgcggaa cattattata    180

acgttgctcg aatactaact gatatctctt cttttttttt ttccggaaaa cagaatcaca    240

taaaaacctt acagaaatgg atggctgaag ttgatgtttt cctgaaagag gaatggcctg    300

ccctggggga tgctgaaatc ctgaaaaaac agctcaaaca atgcaga                  347


<210>  43
<211>  185
<212>  DNA
<213>  artificial

<220>
<223>  Trans-Splicing molecule with no binding domain (AS-)

<400>  43
ccgcggaaca ttattataac gttgctcgaa tactaactga tatctcttct tttttttttt     60

ccggaaaaca gaatcacata aaaaccttac agaaatggat ggctgaagtt gatgttttcc    120

tgaaagagga atggcctgcc ctgggggatg ctgaaatcct gaaaaaacag ctcaaacaat    180

gcaga                                                                185


<210>  44
<211>  515
<212>  DNA
<213>  artificial

<220>
<223>  TS molecule AS1-E24-AS4

<400>  44
cttcatatct tatgtcacta aatatgaaat gaaattatac ctttccttta atacagtact     60

tttaatttaa aaatatatat ctatttatgt ctgtatattt ataaaataat atatagaaaa    120

aaataagaaa aagtcatgtt tttggtcaaa ctcgagagat ctccgcggaa cattattata    180

acgttgctcg aatactaact gatatctctt cttttttttt ttccggaaaa cagaatcaca    240

taaaaacctt acagaaatgg atggctgaag ttgatgtttt cctgaaagag gaatggcctg    300

ccctggggga tgctgaaatc ctgaaaaaac agctcaaaca atgcagagta agaagatctg    360

aattcttagt tccatgtaat tcacaaaatc aagttataat tgtcttcttt tctaaaattt    420

atattgaaaa tacatgcatc acagaaaatt tccctttcaa tatgattaaa atgtggttaa    480

taactacaga tttaaaaaca attgactaaa tataa                               515


<210>  45
<211>  515
<212>  DNA
<213>  artificial

<220>
<223>  TS molecule AS1-E24-AS5

<400>  45
cttcatatct tatgtcacta aatatgaaat gaaattatac ctttccttta atacagtact     60

tttaatttaa aaatatatat ctatttatgt ctgtatattt ataaaataat atatagaaaa    120

aaataagaaa aagtcatgtt tttggtcaaa ctcgagagat ctccgcggaa cattattata    180

acgttgctcg aatactaact gatatctctt cttttttttt ttccggaaaa cagaatcaca    240

taaaaacctt acagaaatgg atggctgaag ttgatgtttt cctgaaagag gaatggcctg    300

ccctggggga tgctgaaatc ctgaaaaaac agctcaaaca atgcagagta agaagatctg    360

aattccacat aaactcaatg ttatggtgtg tttatagttt ccctaaacct gaacttccat    420

aacttgtttt ctgcagttga cagtttaaac agtcccttca gttggggatt ttaaggtaag    480

attttcttac ctttaaagtc aaagctcttg atttc                               515


<210>  46
<211>  515
<212>  DNA
<213>  artificial

<220>
<223>  TS molecule AS1-E24-AS6

<400>  46
cttcatatct tatgtcacta aatatgaaat gaaattatac ctttccttta atacagtact     60

tttaatttaa aaatatatat ctatttatgt ctgtatattt ataaaataat atatagaaaa    120

aaataagaaa aagtcatgtt tttggtcaaa ctcgagagat ctccgcggaa cattattata    180

acgttgctcg aatactaact gatatctctt cttttttttt ttccggaaaa cagaatcaca    240

taaaaacctt acagaaatgg atggctgaag ttgatgtttt cctgaaagag gaatggcctg    300

ccctggggga tgctgaaatc ctgaaaaaac agctcaaaca atgcagagta agaagatctg    360

aattctcatc atgatgatat atccaaacat aagttagaaa aaaaaaaaca atgtatgttt    420

gagggaggtc tcattgtagc tttatagaga ataatatttt tactaagact gcattttatg    480

gtctacactg tgaacattgg tgtatgaagt ctgct                               515


<210>  47
<211>  515
<212>  DNA
<213>  artificial

<220>
<223>  TS molecule AS1-E24-AS7

<400>  47
cttcatatct tatgtcacta aatatgaaat gaaattatac ctttccttta atacagtact     60

tttaatttaa aaatatatat ctatttatgt ctgtatattt ataaaataat atatagaaaa    120

aaataagaaa aagtcatgtt tttggtcaaa ctcgagagat ctccgcggaa cattattata    180

acgttgctcg aatactaact gatatctctt cttttttttt ttccggaaaa cagaatcaca    240

taaaaacctt acagaaatgg atggctgaag ttgatgtttt cctgaaagag gaatggcctg    300

ccctggggga tgctgaaatc ctgaaaaaac agctcaaaca atgcagagta agaagatctg    360

aattccaagt tgcaatcctt tgaaatagat ttggcttttg atatcatcaa tatctttgaa    420

ggactctggg taaaatatct gtttcccatc acattttcca attaattgct atgtgaaaaa    480

atatagttta aaggccaaac ctcggcttac ctgaa                               515


<210>  48
<211>  515
<212>  DNA
<213>  artificial

<220>
<223>  TS molecule AS2-E24-AS4

<400>  48
atatattttc agatttaaaa agaataagta tacaacatgg gatttttaga atcaacaaaa     60

aaattagtct ttatatgtcc tcacatcaca gaagtttctc ttactagtat ttaatttcca    120

gacttaggct attaaaataa ctactcaata ctcgagagat ctccgcggaa cattattata    180

acgttgctcg aatactaact gatatctctt cttttttttt ttccggaaaa cagaatcaca    240

taaaaacctt acagaaatgg atggctgaag ttgatgtttt cctgaaagag gaatggcctg    300

ccctggggga tgctgaaatc ctgaaaaaac agctcaaaca atgcagagta agaagatctg    360

aattcttagt tccatgtaat tcacaaaatc aagttataat tgtcttcttt tctaaaattt    420

atattgaaaa tacatgcatc acagaaaatt tccctttcaa tatgattaaa atgtggttaa    480

taactacaga tttaaaaaca attgactaaa tataa                               515


<210>  49
<211>  515
<212>  DNA
<213>  artificial

<220>
<223>  TS molecule AS2-E24-AS5

<400>  49
atatattttc agatttaaaa agaataagta tacaacatgg gatttttaga atcaacaaaa     60

aaattagtct ttatatgtcc tcacatcaca gaagtttctc ttactagtat ttaatttcca    120

gacttaggct attaaaataa ctactcaata ctcgagagat ctccgcggaa cattattata    180

acgttgctcg aatactaact gatatctctt cttttttttt ttccggaaaa cagaatcaca    240

taaaaacctt acagaaatgg atggctgaag ttgatgtttt cctgaaagag gaatggcctg    300

ccctggggga tgctgaaatc ctgaaaaaac agctcaaaca atgcagagta agaagatctg    360

aattccacat aaactcaatg ttatggtgtg tttatagttt ccctaaacct gaacttccat    420

aacttgtttt ctgcagttga cagtttaaac agtcccttca gttggggatt ttaaggtaag    480

attttcttac ctttaaagtc aaagctcttg atttc                               515


<210>  50
<211>  515
<212>  DNA
<213>  artificial

<220>
<223>  TS molecule AS2-E24-AS6

<400>  50
atatattttc agatttaaaa agaataagta tacaacatgg gatttttaga atcaacaaaa     60

aaattagtct ttatatgtcc tcacatcaca gaagtttctc ttactagtat ttaatttcca    120

gacttaggct attaaaataa ctactcaata ctcgagagat ctccgcggaa cattattata    180

acgttgctcg aatactaact gatatctctt cttttttttt ttccggaaaa cagaatcaca    240

taaaaacctt acagaaatgg atggctgaag ttgatgtttt cctgaaagag gaatggcctg    300

ccctggggga tgctgaaatc ctgaaaaaac agctcaaaca atgcagagta agaagatctg    360

aattctcatc atgatgatat atccaaacat aagttagaaa aaaaaaaaca atgtatgttt    420

gagggaggtc tcattgtagc tttatagaga ataatatttt tactaagact gcattttatg    480

gtctacactg tgaacattgg tgtatgaagt ctgct                               515


<210>  51
<211>  515
<212>  DNA
<213>  artificial

<220>
<223>  TS molecule AS2-E24-AS7

<400>  51
atatattttc agatttaaaa agaataagta tacaacatgg gatttttaga atcaacaaaa     60

aaattagtct ttatatgtcc tcacatcaca gaagtttctc ttactagtat ttaatttcca    120

gacttaggct attaaaataa ctactcaata ctcgagagat ctccgcggaa cattattata    180

acgttgctcg aatactaact gatatctctt cttttttttt ttccggaaaa cagaatcaca    240

taaaaacctt acagaaatgg atggctgaag ttgatgtttt cctgaaagag gaatggcctg    300

ccctggggga tgctgaaatc ctgaaaaaac agctcaaaca atgcagagta agaagatctg    360

aattccaagt tgcaatcctt tgaaatagat ttggcttttg atatcatcaa tatctttgaa    420

ggactctggg taaaatatct gtttcccatc acattttcca attaattgct atgtgaaaaa    480

atatagttta aaggccaaac ctcggcttac ctgaa                               515


<210>  52
<211>  515
<212>  DNA
<213>  artificial

<220>
<223>  TS molecule AS2-E24-AS8

<400>  52
atatattttc agatttaaaa agaataagta tacaacatgg gatttttaga atcaacaaaa     60

aaattagtct ttatatgtcc tcacatcaca gaagtttctc ttactagtat ttaatttcca    120

gacttaggct attaaaataa ctactcaata ctcgagagat ctccgcggaa cattattata    180

acgttgctcg aatactaact gatatctctt cttttttttt ttccggaaaa cagaatcaca    240

taaaaacctt acagaaatgg atggctgaag ttgatgtttt cctgaaagag gaatggcctg    300

ccctggggga tgctgaaatc ctgaaaaaac agctcaaaca atgcagagta agaagatctg    360

aattcctaca acttaaaaaa tgaacataat ggaataagga tattttaaat tattatgtta    420

aaatgttaag tatacttgga gttggtgaaa aaaaatcaat tcatttatac agacaatcca    480

agaaggtatg acacattact gttttcatag gaaaa                               515


<210>  53
<211>  671
<212>  DNA
<213>  artificial

<220>
<223>  TS molecule AS2-E24-2XAS4

<400>  53
atatattttc agatttaaaa agaataagta tacaacatgg gatttttaga atcaacaaaa     60

aaattagtct ttatatgtcc tcacatcaca gaagtttctc ttactagtat ttaatttcca    120

gacttaggct attaaaataa ctactcaata ctcgagagat ctccgcggaa cattattata    180

acgttgctcg aatactaact gatatctctt cttttttttt ttccggaaaa cagaatcaca    240

taaaaacctt acagaaatgg atggctgaag ttgatgtttt cctgaaagag gaatggcctg    300

ccctggggga tgctgaaatc ctgaaaaaac agctcaaaca atgcagagta agaagatctg    360

aattcttagt tccatgtaat tcacaaaatc aagttataat tgtcttcttt tctaaaattt    420

atattgaaaa tacatgcatc acagaaaatt tccctttcaa tatgattaaa atgtggttaa    480

taactacaga tttaaaaaca attgactaaa tataagaatt cttagttcca tgtaattcac    540

aaaatcaagt tataattgtc ttcttttcta aaatttatat tgaaaataca tgcatcacag    600

aaaatttccc tttcaatatg attaaaatgt ggttaataac tacagattta aaaacaattg    660

actaaatata a                                                         671


<210>  54
<211>  543
<212>  DNA
<213>  artificial

<220>
<223>   TS molecule AS2-E24-AS4 comprising DISE

<400>  54
atatattttc agatttaaaa agaataagta tacaacatgg gatttttaga atcaacaaaa     60

aaattagtct ttatatgtcc tcacatcaca gaagtttctc ttactagtat ttaatttcca    120

gacttaggct attaaaataa ctactcaata ctcgagagat ctccgcggaa cattattata    180

acgttgctcg aatactaact gatatctctt cttttttttt ttccggaaaa cagaatcaca    240

taaaaacctt acagaaatgg atggctgaag ttgatgtttt cctgaaagag gaatggcctg    300

ccctggggga tgctgaaatc ctgaaaaaac agctcaaaca atgcagagta agaacagctc    360

tttctttcca tgggttggcc tagatctgaa ttcttagttc catgtaattc acaaaatcaa    420

gttataattg tcttcttttc taaaatttat attgaaaata catgcatcac agaaaatttc    480

cctttcaata tgattaaaat gtggttaata actacagatt taaaaacaat tgactaaata    540

taa                                                                  543


<210>  55
<211>  537
<212>  DNA
<213>  artificial

<220>
<223>  TS molecule AS2-E24-AS8 comprising DISE

<400>  55
atatattttc agatttaaaa agaataagta tacaacatgg gatttttaga atcaacaaaa     60

aaattagtct ttatatgtcc tcacatcaca gaagtttctc ttactagtat ttaatttcca    120

gacttaggct attaaaataa ctactcaata ctcgagagat ctccgcggaa cattattata    180

acgttgctcg aatactaact gatatctctt cttttttttt ttccggaaaa cagaatcaca    240

taaaaacctt acagaaatgg atggctgaag ttgatgtttt cctgaaagag gaatggcctg    300

ccctggggga tgctgaaatc ctgaaaaaac agctcaaaca atgcagagta agaacagctc    360

tttctttcca tgggttggcc tgaattccta caacttaaaa aatgaacata atggaataag    420

gatattttaa attattatgt taaaatgtta agtatacttg gagttggtga aaaaaaatca    480

attcatttat acagacaatc caagaaggta tgacacatta ctgttttcat aggaaaa       537


<210>  56
<211>  545
<212>  DNA
<213>  artificial

<220>
<223>  TS molecule AS2-ISE-E24-AS4

<400>  56
atatattttc agatttaaaa agaataagta tacaacatgg gatttttaga atcaacaaaa     60

aaattagtct ttatatgtcc tcacatcaca gaagtttctc ttactagtat ttaatttcca    120

gacttaggct attaaaataa ctactcaata ctcgagagat ctccgcggaa cattattata    180

acgttgctcg aaggctgagg gaaggactgt cctggggact ggtactaact gatatctctt    240

cttttttttt ttccggaaaa cagaatcaca taaaaacctt acagaaatgg atggctgaag    300

ttgatgtttt cctgaaagag gaatggcctg ccctggggga tgctgaaatc ctgaaaaaac    360

agctcaaaca atgcagagta agaagatctg aattcttagt tccatgtaat tcacaaaatc    420

aagttataat tgtcttcttt tctaaaattt atattgaaaa tacatgcatc acagaaaatt    480

tccctttcaa tatgattaaa atgtggttaa taactacaga tttaaaaaca attgactaaa    540

tataa                                                                545


<210>  57
<211>  699
<212>  DNA
<213>  artificial

<220>
<223>  TS molecule AS2-E24-DISE-2XAS4

<400>  57
atatattttc agatttaaaa agaataagta tacaacatgg gatttttaga atcaacaaaa     60

aaattagtct ttatatgtcc tcacatcaca gaagtttctc ttactagtat ttaatttcca    120

gacttaggct attaaaataa ctactcaata ctcgagagat ctccgcggaa cattattata    180

acgttgctcg aatactaact gatatctctt cttttttttt ttccggaaaa cagaatcaca    240

taaaaacctt acagaaatgg atggctgaag ttgatgtttt cctgaaagag gaatggcctg    300

ccctggggga tgctgaaatc ctgaaaaaac agctcaaaca atgcagagta agaacagctc    360

tttctttcca tgggttggcc tagatctgaa ttcttagttc catgtaattc acaaaatcaa    420

gttataattg tcttcttttc taaaatttat attgaaaata catgcatcac agaaaatttc    480

cctttcaata tgattaaaat gtggttaata actacagatt taaaaacaat tgactaaata    540

taagaattct tagttccatg taattcacaa aatcaagtta taattgtctt cttttctaaa    600

atttatattg aaaatacatg catcacagaa aatttccctt tcaatatgat taaaatgtgg    660

ttaataacta cagatttaaa aacaattgac taaatataa                           699


<210>  58
<211>  164
<212>  DNA
<213>  artificial

<220>
<223>  Antisense sequence AS3bis

<400>  58
agagcctcaa aattaaatag aagttcattt acactaacac gcatatttga tgagtttcat     60

tcatatcaag aagaaggtaa ataaaagttt atgtaattta gagatctaaa caaagtagaa    120

tatctgataa agcaatatat atgtattctt atgaataatt tcta                     164


<210>  59
<211>  42
<212>  DNA
<213>  artificial

<220>
<223>  Spacer sequence

<400>  59
ctcgagagat ctccgcggaa cattattata acgttgctcg aa                        42


<210>  60
<211>  213
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Nucleotide sequence of the human dystrophin gene DMD, exon 23

<400>  60
gctttacaaa gttctctgca agagcaacaa agtggcctat actatctcag caccactgtg     60

aaagagatgt cgaagaaagc gccctctgaa attagccgga aatatcaatc agaatttgaa    120

gaaattgagg gacgctggaa gaagctctcc tcccagctgg ttgagcattg tcaaaagcta    180

gaggagcaaa tgaataaact ccgaaaaatt cag                                 213


<210>  61
<211>  3453
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Nucleotide sequence of the human dystrophin gene DMD, intron 22

<400>  61
gtctgtgaat atttgaatgt caaaacaata aagcacgctt atcaagcatt cacattgata     60

taacctttaa ataatattag aatttaagtc attctgacaa gtatggtagt ttgcccattg    120

agcaaatgaa aatgagactt tacagtatta tttatgcata tactctatct atggatatat    180

atgtatgggc atatatacat gctgtttttg aaaacaattg tatgatctat ttatgaagta    240

tatttttaat ttagcatgca ttttcagatg tattgatttt gattattaga aaaaccattg    300

ttttattccc cacctttgct tctttatttg taactcctgt cacattctca aactggtggg    360

taaaatcagt gtacagtcat cccttcgtat ccatggggaa gtggttccag gaactcctat    420

gaatatcaga attcacagat gttcaagtcc tttatatgaa tggtgtaata tttgcatata    480

acttatgaac atgctcccat atactttaac tcatctctgg attacttata atgcctaata    540

caatgtaaat attatgaaaa tatgtgttat actgtattat ttaggaagta gtgacaatga    600

aaaagtctta catgtttagt acagatgtag ttatttttgt caaatattat ctattagtag    660

ttgactgaat ccactcattc agaatccaca aatatggagg gctggctata tttataaaat    720

tggtttaaat ttaaacatta attttctgta atgtaatgag acatttgaat tctaatagct    780

acattttttt aacatccttc tatcaggaaa gatatactaa tatgggaaat gaaagaaata    840

atttgtaaga gattttataa tacttttcct actttatttt atttttagac ggagtttcat    900

tcttgttgcc caggctggag tgcagcagtg ctatctcggc tcactgcaac ctacgcctcc    960

cgggttcaag tgattctcct gccttagcct cctgagtagc tgggattata gtgcgtgcca   1020

tcacgcctgg ctaatttttg tatttttaaa gtaaagatgg ggtttcacca tcttggccat   1080

gctggtctca aactcctgac ctcagatgat ctgcctgcct cagcctccca aagtgctggg   1140

attacaggtg tgagccactg cgcccagccc ttttcctact tattataaaa tactacatta   1200

tatgttcaat aactttttat ttctgaagac atgaaaacgt attagttata tttagaagct   1260

gagataatat gtgcatttta agaaaaatgt ttaaaaattc aaatttaaac tttatcacat   1320

agaatttttt ttggataatt aaatattttt ttgaagtaat gtattcaaag aaaaatacat   1380

ttaaacaact ttcattatgt attgtcctat ttagatattt attctactac aataccaaat   1440

ggtagctgtt tcaccttttt tgtttccttt tgttgtggtt tttaatgctt ggcataatga   1500

ttccaaagtc tatctggaaa aatgtgttgc ctaatagaac tagtaaactt ttaaacataa   1560

gaataaaaat gtgcaagaat aagagtggag aaaacacaag aaaaggcagt tagatgagca   1620

gaagagacta tttccactga aaaagatagg aaagaaaata attgttcata aatattattg   1680

ggaaatgtat taactaacta aaaaaaaaga tatgaacatt tcccccaaag ttacaccaaa   1740

ataaaaacca catacaataa aatgttcaaa aaatgtgggg aagcccaaat tttggaaaat   1800

atttaaaata ataatgttat aaaaatttag gtggagaagc ataaaaatcg atggaaacaa   1860

tcacaaacat tgtaaaaaca ccagagacaa ttttaaagaa atatgatacc aaggaatctt   1920

tttttttctg tgagtaagga agaaagtctt gagtaaggta tcctccaaaa agagacatat   1980

atgaataata aacctatgaa taattgtaac ttaaattgta aaggaagaag taaaaaaatt   2040

acaagatgag aatttttttt gcatactaaa ttgcatacac acaaaagata taagtaccaa   2100

tttgcaagtg gtgaaataaa aattgtctct tactgctgga aatgtaaatt caatatgaat   2160

tttactgagg ttaactcttc agtgcatcct aataacatac aacattaata taatttccat   2220

gaaatctgta tctgatggaa ataatcagaa tacactcaaa gatgtaaatg gaactggaga   2280

tagataggat attgattgat tgagggatgg atggatggat tagataggta ggtagataga   2340

gataaacata atttacagga gtggaaaact agaaatgaat gtgtagaact aataatggaa   2400

attgttgaac tagaaaagcc attacaattt ttgtttttga aaaaataatt atttgacatg   2460

ggcaaatgct cacactaaaa cacctagctc aaagtgtagt tatatgctag atattgtcta   2520

aataatcagt cataggggaa caatttgaaa aagtgaaata aacttaaaaa agtaaagtaa   2580

aaaaacaaat taagtaccac caaataggca taggatacta tgaaactata aaacttagat   2640

atttgacaaa ttttgggttg atataggtca cattataggg gaaagaataa ctgtttatat   2700

gtgcatacat gatcatatat ttaatattta gctatacata gaacaaattg aaaatttata   2760

taaagtacta gtagttctgg tttttttttc catttttgtc atgagccttt attattttat   2820

aaagtaaaag taacattaaa gtaaatattg aacaggggaa gtctaaagtt atgatcctac   2880

tgtaagaaat tacatgtgtt atacagaata agtataaata aattttataa attctccaca   2940

aaactatcct tgaatcccac cataatacta cataacagaa taacattttt tgaaaatata   3000

ttaagtacat agattgttca ataagttttt ctattccata tatcaatatt attagctata   3060

gttttatgta gagtttactt tcctgaaagc tcagtataat taatttcaac tccattaact   3120

gtatcacaaa tgcagttatt aatatatata cttaattcag taaaattaga tgcaccaaaa   3180

ctttttggct ctgtaagata tagttttgag atatatttga cattgttcag aaaaatacat   3240

atggagtgtt aaataccact aaataatatt caagttactc ttaggataat atgtaaaatt   3300

taaattacca ctagaagttt ataactgata gaagatcatc tactttgttt acatgtttga   3360

atcatataga tttcaagtac agttaatttc actaaaactc atcaattatt attcatcaat   3420

tagggtaaat gtatttaaaa aattgttttt tag                                3453


<210>  62
<211>  3798
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Nucleotide sequence of the human dystrophin gene DMD, intron 23

<400>  62
gtaattcaag attttacttt ctaccctcat ttttatttac ttgttttttc cctaacgata     60

cactgtaaac tgtaaaggta cataagcatt tgaccttcag catctttcaa agttagtgag    120

aagatgaaaa gacatgagtc ttttacaaag gatggcgatt tgcttattcc ttctaggaaa    180

agaataggag ttttctcagt gtttttagaa tgaattttct attttcacca ttaccaatag    240

gaattaaaca tgtttttagt ttaataattt tcaaaaccaa tcatccattt agtctggttg    300

tcttttaaga tacgggtaat catttagctt atgactagaa aaaagttatg tatatataca    360

ttatacagag gtatattgta atcattttat atatataatg tatagtatgt atatgattat    420

ttcctatatt acctttcatt tctgctgttt tgctacttat aaaaagtagg agtcaactat    480

gctgtctata tgtgctatta tatataaaat atggtgatat gttcataaaa ttgcattata    540

tattcatccc attatgtata actccatata tgtatatgtg cagtagaaat gtaggtgtat    600

taatgtccta tgatactcct aagaaattag cagaaattta atggcttcaa acaacacaaa    660

tttattacat tactgttctg gaggtcagaa gttcagaatt aatctctgtg ggctaaaatt    720

aaggtgttag cagaactgtg tctgttttgg agactttgaa agagaatgtg tgttattggc    780

atttttagct tccatatata tatgtatata tatacacaca catacatata acatgtatat    840

atgtgtgtat atatatatat atatacgtgt ataatggaat tatatatcat gtacatatat    900

acatatctaa tgtaatatat atcacatatg taacctgttg tatatgtata ttaatgttac    960

atatgtaata tatagtaata acttatttta tcaccatatc gaatttgtaa ttatatgctt   1020

aaattttacc acatcacctt cttcctgaaa ccaaattccc ttgacttaat ttgtttgaat   1080

agtgccacca tactaataac cactcaagct aaagaaaaac agtaaaccaa caattgcatt   1140

aaggtctaaa agcctaaaat attcaataag gtaagtaatg tgtcccttga gtggtcaatt   1200

attgtgacaa atgttaatgc tgggaaggaa atgtcgaaaa cgttatggta tgatggaaaa   1260

acattgcaac aatatgctcc tggatttaaa tcccagtcta gctgcttagt ttttgtgctt   1320

accttttaca aaccaaagca ctaagcaaac ctaaaacatt ttttaatgca tagcatttct   1380

ttacttataa acatatgtgt acatgcatac ctatgtaaat actgcatgaa aatatctatt   1440

atttgtcaag accagtggcc taagagggca caattacatg gctcttgtta tcaaggagcc   1500

cacattctag tgaaggagga aggtaggtgt attcatttcc tatggcactc ctaacaaatt   1560

gccggaaatt taataacttc aagcaacaca aatttattag agttctggaa gtcaaaagtt   1620

caggattagt ctcagtgggc taaaattaag gtgtcagcag gactttgtct gttttggagg   1680

ctttgcgaca gagtctgttt tattggcatt tttagcttct agaagcattc cttgtctcat   1740

gtccccatcc tccatcttca aagtcagcag tgtaacatca tctagtgtca atttctctct   1800

ccctgtctat ctccctctcc ctctctttct acctctcctt ctcaccttcc tttccctatc   1860

ctgttccctg tgttgacttc cttttaatta ggacctttgt gattacatta tgccctggtg   1920

gatgatccag tataatctcc ccatctcaga atccttaatg taatcacatc tgcaaagtcc   1980

tttctggtaa tatactcaca ggtttcagag attagggtga ggacatcttg ggggtagcat   2040

tattcagcct tgcatggtaa ataaattaaa cagtatggga aaggttgtca cagtaggcag   2100

gaaggaaatc caacataaac taggaaaaag gattatgaaa tattatcgga acataggttg   2160

tctctgctat agattaaata ggtagaattt agttagctaa taccgagaaa gaaagagttc   2220

ttgagaaagc atagcagcat tttcagttaa atgatataag ttcaacactg ggtagacaat   2280

atatatgggg attaataaaa tattatggtt ggaaaactgg attgagagta gacagtgaat   2340

gtccttggat gctatgtttt acaatctgag ttttaatcta gtggtgatgg gactgataat   2400

aataacaata aaaacttaat aagaaaaaac tgctattggt taaagaggga aataatatga   2460

ttccacttgt gttttcaaaa cattcccaag atgagaggaa ggaggagagg agattactgg   2520

catcactgta gatcagtaat tagaatgagg tgagaccgag gcagatatca aaacgagcca   2580

gtgcattaat ggagtcacta atgagacctg aacagcccag gcgtagtggc tcatgcctat   2640

aatcccagca ctctgggcag ctgaggcagg tagatcacga ggtcaagaga tcaagaccat   2700

gctggccaac atggcgaaac cctgtctcta ctaaaaacac aaaaattagc tgggcatggt   2760

agtgcacgcc tgtaatccca gctacttggg aggctgaggc aggagaatgg cgtgaacctg   2820

ggaggtggag gctgcagtga gccaagattg tgccacttca ctccagcctg ggcgacagag   2880

caagactcca tctcaaaaaa aaaaaaaaaa aaaaacaaaa aacaaacaaa aaaaaaaaga   2940

cctgaacaag gacagtgaag atgtgaaata agaacaaatg tagacttgaa agataacagc   3000

aaggtgatcg tcttgaagtt ctcttagata aatagtttaa aaattattat taataatcac   3060

attaaagggg aaactttctg tggagcacat attttcaatg taaatttaag taaaacagaa   3120

gaaaataaca catgtagaca gcatagttga atcatacttt ttagaagtgg caaaacagca   3180

gaaaaaaagg taatacggga aagaatcatg ggtgagagat actggctatt tataaatgat   3240

aaaagatgat gatttttacc tgatcattac ttcgtactgg tcagacaaat aaaagcaaaa   3300

gctctgtctt tgaagatgac aaaatattag tccaaaagtt cccaactgga aggactattt   3360

aaactgtcat ctgtagaaaa taatttgtga aagttcgggt ttagggaggc tataaagaca   3420

ccattacatt gagtttattg ttcatagttt gttttatgta ctgtaaggac acatttttag   3480

tattctcatg agttgttttg taacttaaaa tttctctaga gggggatatg atttaatgtt   3540

ctcgagagta acatcataaa accacatttg gtagtaattt tgtattttta acaatagcag   3600

acttcacaca ccagtgctca tacagtagac cataaaaatg cagtcttagt aaaaatattc   3660

tttgcctcaa gaactactta gagacatcct ttaaacatgg gaattgtttt tgggcctgtg   3720

tttagacata acacaatgat gaattgtgtt aaaagtaatc agcacaccag taatgcctta   3780

taacgggtct cgtttcag                                                 3798


<210>  63
<211>  71
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Human sequence of the dystrophin gene DMD, exon 23

<400>  63

Ala Leu Gln Ser Ser Leu Gln Glu Gln Gln Ser Gly Leu Tyr Tyr Leu 
1               5                   10                  15      

Ser Thr Thr Val Lys Glu Met Ser Lys Lys Ala Pro Ser Glu Ile Ser 
            20                  25                  30          

Arg Lys Tyr Gln Ser Glu Phe Glu Glu Ile Glu Gly Arg Trp Lys Lys 
        35                  40                  45              

Leu Ser Ser Gln Leu Val Glu His Cys Gln Lys Leu Glu Glu Gln Met 
    50                  55                  60                  

Asn Lys Leu Arg Lys Ile Gln 
65                  70      


<210>  64
<211>  114
<212>  DNA
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Human nucleotide sequence of the dystrophin gene DMD, exon 24

<400>  64
aatcacatac aaaccctgaa gaaatggatg gctgaagttg atgtttttct gaaggaggaa     60

tggcctgccc ttggggattc agaaattcta aaaaagcagc tgaaacagtg caga          114


<210>  65
<211>  38
<212>  PRT
<213>  homo sapiens


<220>
<221>  misc_feature
<223>  Human sequence of the dystrophin gene DMD, exon 24

<400>  65

Asn His Ile Gln Thr Leu Lys Lys Trp Met Ala Glu Val Asp Val Phe 
1               5                   10                  15      

Leu Lys Glu Glu Trp Pro Ala Leu Gly Asp Ser Glu Ile Leu Lys Lys 
            20                  25                  30          

Gln Leu Lys Gln Cys Arg 
        35              


<210>  66
<211>  608
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Murine sequence of the dystrophin gene DMD, intron 58

<400>  66
gtaattgaat gtggaactgt aataacatat tgatagaggg ctcagtgatg agagcacagc     60

ccatccatgc ttgctgccag agtctgtata gctctcacac ttcagggtta aacagaatca    120

attcaaatta aatgtaggtg ctgaaaaaga atacagaatc acaaaccacc atgcacaatt    180

ctgttttcag tcataaataa agcaatcaat gatcagttat ttgaatattt agaaaatggt    240

aagcaaaaga tcttatctgt gataagaagt tctattgtta caaagactgc aagctaattt    300

tccgtttaag ctgactgaaa taaattggag ctgttcagca catgctaaca tttttctctc    360

tgaaagctta aatgaatctt gatttacctg attgacagaa agtagaacag attcactaag    420

gaagacagtt tagctgtgct tgactatatc aaaatttatg ccaaagtgta aaagagccat    480

taatcagtaa gttggcctcg tgttaatcta tattcctttc ctttcttcta gtctgacctt    540

ttcaaccatg tttttttttt ttaacaaaaa tggatgtgac cttaaacctt gtcatattgc    600

caatttag                                                             608


<210>  67
<211>  608
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human sequence of the dystrophin gene DMD, intron 58

<400>  67
gtaattgaat gtggaactat aataacatat tgatagaagg atcagtggtg acggagcagc     60

ccatccattc ttgctgccag ggtctggata gctctcatat tttcttggtt aaatagaatc    120

aattcaaatt aaacatagat gctgaaaaaa aaataaggac tcataaacta ccatgcataa    180

atcagtttgt gcattcataa ataaacatca aaagagatta gcaatcagtt attggaacat    240

ttagaaaata ataaacaaag ggagttatct gtgaggagga attctattgt tgcaaagact    300

acaagttaat tttccattta agagcctgcc tgaagtaaat tagagcttgt ggtatgcatc    360

ctaacgtttt tctcctcaat agcttaagtg aatcttaaat tgtcggattg atataaggta    420

gaaactcagg aagatatact ttagatgttc tgggctgtat caaaatttat gccaaagtat    480

aaaaaagccg ttaatcagta ggttaccctc ttgttcaact gtactctttc tttcttccag    540

tatgaccttt ttgacaatgt ttaaaaaaaa agaatgtggc ctaaaacctt gtcatattgc    600

caatttag                                                             608


<210>  68
<211>  150
<212>  DNA
<213>  Artificial

<220>
<223>  Antisens sequence to intron 58 of DMD

<400>  68
aaaattaact tgtagtcttt gcaacaatag aattcctcct cacagataac tccctttgtt     60

tattattttc taaatgttcc aataactgat tgctaatctc ttttgatgtt tatttatgaa    120

tgcacaaact gatttatgca tggtagttta                                     150


<210>  69
<211>  2390
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Murine sequence of the dystrophin gene DMD, exons 59-79

<400>  69
aactgcctcc tgaagaaaga gctcagaatg tcactcggct cctacgaaag caggctgaag     60

aggtcaacgc tgaatgggac aaattgaacc tgcgctcagc tgattggcag agaaaaatag    120

atgaagctct tgaaagactc caggaacttc aggaagctgc cgatgaactg gacctcaagt    180

tgcgccaagc tgaggtgatc aagggatcct ggcagccagt gggggatctc ctcattgact    240

ctctgcaaga tcaccttgaa aaagtcaagg cacttcgggg agaaattgca cctcttaaag    300

agaatgtcaa tcgtgtcaat gaccttgcac atcagctgac cacactgggc attcagctct    360

caccttataa cctcagcact ttggaagatc tgaataccag atggaggctt ctacaggtgg    420

ctgtggagga ccgtgtcaga cagctgcatg aagcccacag ggactttggt cctgcatccc    480

agcacttcct ttccacttca gttcagggtc cctgggagag agccatctca ccaaacaaag    540

tgccctacta tatcaaccac gagacccaaa ccacttgttg ggaccacccc aaaatgacag    600

agctctacca gtctttagct gacctgaata atgtcaggtt ctccgcgtat aggactgcca    660

tgaagctcag aaggctccag aaggcccttt gcttggatct cttgagcctg tcagctgcat    720

gtgatgccct ggaccagcac aacctcaagc aaaatgacca gcccatggat atcctgcaga    780

taattaactg tttgactaca atttatgatc gtctggagca agagcacaac aatctggtca    840

atgtccctct ctgtgtggat atgtgtctca actggcttct caatgtttat gatacgggac    900

gaacagggag gatccgtgtc ctgtctttta aaactggcat catttctctg tgtaaagcac    960

acttggaaga caagtacaga taccttttca agcaagtggc aagttcaact ggcttttgtg   1020

accagcgtag gctgggtctt cttctgcatg attctattca aatcccaaga cagttgggtg   1080

aagttgcttc ctttgggggc agtaacattg agccgagtgt caggagctgc ttccaatttg   1140

ccaataataa acctgagatt gaagctgctc tcttccttga ctggatgcgc ctggaacccc   1200

agtctatggt gtggctgccc gtcttgcaca gagtggctgc tgctgaaact gccaagcatc   1260

aagccaagtg taacatctgt aaggagtgtc caatcattgg attcaggtac agaagcctaa   1320

agcattttaa ttatgacatc tgccaaagtt gctttttttc tggccgagtt gcaaagggcc   1380

ataaaatgca ctaccccatg gtagagtatt gcactccgac tacatccgga gaagatgttc   1440

gcgacttcgc caaggtacta aaaaacaaat ttcgaaccaa aaggtatttt gcgaagcatc   1500

cccgaatggg ctacctgcca gtgcagactg tgttagaggg ggacaacatg gaaactcccg   1560

ttactctgat caacttctgg ccagtagatt ctgcgcctgc ctcgtccccc cagctttcac   1620

acgatgatac tcattcacgc attgaacatt atgctagcag gctagcagaa atggaaaaca   1680

gcaatggatc ttatctaaat gatagcatct ctcctaatga gagcatagat gatgaacatt   1740

tgttaatcca gcattactgc caaagtttga accaggactc ccccctgagc cagcctcgta   1800

gtcctgccca gatcttgatt tccttagaga gtgaggaaag aggggagcta gagagaatcc   1860

tagcagatct tgaggaagaa aacaggaatc tgcaagcaga atatgatcgc ctgaagcagc   1920

agcatgagca taaaggcctg tctccactgc catctcctcc tgagatgatg cccacctctc   1980

ctcagagtcc cagggatgct gagctcattg ctgaggctaa gctactgcgc caacacaaag   2040

gacgcctgga agccaggatg caaatcctgg aagaccacaa taaacagctg gagtctcagt   2100

tacatagact gagacagctc ctggagcagc cccaggctga agctaaggtg aatggcacca   2160

cggtgtcctc tccttccacc tctctgcaga ggtcagatag cagtcagcct atgctgctcc   2220

gagtggttgg cagtcaaact tcagaatcta tgggtgagga agatcttctg agtcctcccc   2280

aggacacaag cacagggtta gaagaagtga tggagcaact caacaactcc ttccctagtt   2340

caagaggaag aaatgccccc ggaaagccaa tgagagagga cacaatgtag              2390


<210>  70
<211>  2390
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human sequence of the dystrophin gene DMD, exons 59-79

<400>  70
agctgcctcc tgaggagaga gcccagaatg tcactcggct tctacgaaag caggctgagg     60

aggtcaatac tgagtgggaa aaattgaacc tgcactccgc tgactggcag agaaaaatag    120

atgagaccct tgaaagactc caggaacttc aagaggccac ggatgagctg gacctcaagc    180

tgcgccaagc tgaggtgatc aagggatcct ggcagcccgt gggcgatctc ctcattgact    240

ctctccaaga tcacctcgag aaagtcaagg cacttcgagg agaaattgcg cctctgaaag    300

agaacgtgag ccacgtcaat gaccttgctc gccagcttac cactttgggc attcagctct    360

caccgtataa cctcagcact ctggaagacc tgaacaccag atggaagctt ctgcaggtgg    420

ccgtcgagga ccgagtcagg cagctgcatg aagcccacag ggactttggt ccagcatctc    480

agcactttct ttccacgtct gtccagggtc cctgggagag agccatctcg ccaaacaaag    540

tgccctacta tatcaaccac gagactcaaa caacttgctg ggaccatccc aaaatgacag    600

agctctacca gtctttagct gacctgaata atgtcagatt ctcagcttat aggactgcca    660

tgaaactccg aagactgcag aaggcccttt gcttggatct cttgagcctg tcagctgcat    720

gtgatgcctt ggaccagcac aacctcaagc aaaatgacca gcccatggat atcctgcaga    780

ttattaattg tttgaccact atttatgacc gcctggagca agagcacaac aatttggtca    840

acgtccctct ctgcgtggat atgtgtctga actggctgct gaatgtttat gatacgggac    900

gaacagggag gatccgtgtc ctgtctttta aaactggcat catttccctg tgtaaagcac    960

atttggaaga caagtacaga taccttttca agcaagtggc aagttcaaca ggattttgtg   1020

accagcgcag gctgggcctc cttctgcatg attctatcca aattccaaga cagttgggtg   1080

aagttgcatc ctttgggggc agtaacattg agccaagtgt ccggagctgc ttccaatttg   1140

ctaataataa gccagagatc gaagcggccc tcttcctaga ctggatgaga ctggaacccc   1200

agtccatggt gtggctgccc gtcctgcaca gagtggctgc tgcagaaact gccaagcatc   1260

aggccaaatg taacatctgc aaagagtgtc caatcattgg attcaggtac aggagtctaa   1320

agcactttaa ttatgacatc tgccaaagct gctttttttc tggtcgagtt gcaaaaggcc   1380

ataaaatgca ctatcccatg gtggaatatt gcactccgac tacatcagga gaagatgttc   1440

gagactttgc caaggtacta aaaaacaaat ttcgaaccaa aaggtatttt gcgaagcatc   1500

cccgaatggg ctacctgcca gtgcagactg tcttagaggg ggacaacatg gaaactcccg   1560

ttactctgat caacttctgg ccagtagatt ctgcgcctgc ctcgtcccct cagctttcac   1620

acgatgatac tcattcacgc attgaacatt atgctagcag gctagcagaa atggaaaaca   1680

gcaatggatc ttatctaaat gatagcatct ctcctaatga gagcatagat gatgaacatt   1740

tgttaatcca gcattactgc caaagtttga accaggactc ccccctgagc cagcctcgta   1800

gtcctgccca gatcttgatt tccttagaga gtgaggaaag aggggagcta gagagaatcc   1860

tagcagatct tgaggaagaa aacaggaatc tgcaagcaga atatgaccgt ctaaagcagc   1920

agcacgaaca taaaggcctg tccccactgc cgtcccctcc tgaaatgatg cccacctctc   1980

cccagagtcc ccgggatgct gagctcattg ctgaggccaa gctactgcgt caacacaaag   2040

gccgcctgga agccaggatg caaatcctgg aagaccacaa taaacagctg gagtcacagt   2100

tacacaggct aaggcagctg ctggagcaac cccaggcaga ggccaaagtg aatggcacaa   2160

cggtgtcctc tccttctacc tctctacaga ggtccgacag cagtcagcct atgctgctcc   2220

gagtggttgg cagtcaaact tcggactcca tgggtgagga agatcttctc agtcctcccc   2280

aggacacaag cacagggtta gaggaggtga tggagcaact caacaactcc ttccctagtt   2340

caagaggaag aaatacccct ggaaagccaa tgagagagga cacaatgtag              2390


<210>  71
<211>  2617
<212>  DNA
<213>  Artificial

<220>
<223>  Simple PTM

<400>  71
aaaattaact tgtagtcttt gcaacaatag aattcctcct cacagataac tccctttgtt     60

tattattttc taaatgttcc aataactgat tgctaatctc ttttgatgtt tatttatgaa    120

tgcacaaact gatttatgca tggtagttta ggtaccccgc ggaacattat tataacgttg    180

ctcgaatact aactgatatc tcttcttttt ttttttccgg aaaacagagc tgcctcctga    240

ggagagagcc cagaatgtca ctcggcttct acgaaagcag gctgaggagg tcaatactga    300

gtgggaaaaa ttgaacctgc actccgctga ctggcagaga aaaatagatg agacccttga    360

aagactccag gaacttcaag aggccacgga tgagctggac ctcaagctgc gccaagctga    420

ggtgatcaag ggatcctggc agcccgtggg cgatctcctc attgactctc tccaagatca    480

cctcgagaaa gtcaaggcac ttcgaggaga aattgcgcct ctgaaagaga acgtgagcca    540

cgtcaatgac cttgctcgcc agcttaccac tttgggcatt cagctctcac cgtataacct    600

cagcactctg gaagacctga acaccagatg gaagcttctg caggtggccg tcgaggaccg    660

agtcaggcag ctgcatgaag cccacaggga ctttggtcca gcatctcagc actttctttc    720

cacgtctgtc cagggtccct gggagagagc catctcgcca aacaaagtgc cctactatat    780

caaccacgag actcaaacaa cttgctggga ccatcccaaa atgacagagc tctaccagtc    840

tttagctgac ctgaataatg tcagattctc agcttatagg actgccatga aactccgaag    900

actgcagaag gccctttgct tggatctctt gagcctgtca gctgcatgtg atgccttgga    960

ccagcacaac ctcaagcaaa atgaccagcc catggatatc ctgcagatta ttaattgttt   1020

gaccactatt tatgaccgcc tggagcaaga gcacaacaat ttggtcaacg tccctctctg   1080

cgtggatatg tgtctgaact ggctgctgaa tgtttatgat acgggacgaa cagggaggat   1140

ccgtgtcctg tcttttaaaa ctggcatcat ttccctgtgt aaagcacatt tggaagacaa   1200

gtacagatac cttttcaagc aagtggcaag ttcaacagga ttttgtgacc agcgcaggct   1260

gggcctcctt ctgcatgatt ctatccaaat tccaagacag ttgggtgaag ttgcatcctt   1320

tgggggcagt aacattgagc caagtgtccg gagctgcttc caatttgcta ataataagcc   1380

agagatcgaa gcggccctct tcctagactg gatgagactg gaaccccagt ccatggtgtg   1440

gctgcccgtc ctgcacagag tggctgctgc agaaactgcc aagcatcagg ccaaatgtaa   1500

catctgcaaa gagtgtccaa tcattggatt caggtacagg agtctaaagc actttaatta   1560

tgacatctgc caaagctgct ttttttctgg tcgagttgca aaaggccata aaatgcacta   1620

tcccatggtg gaatattgca ctccgactac atcaggagaa gatgttcgag actttgccaa   1680

ggtactaaaa aacaaatttc gaaccaaaag gtattttgcg aagcatcccc gaatgggcta   1740

cctgccagtg cagactgtct tagaggggga caacatggaa actcccgtta ctctgatcaa   1800

cttctggcca gtagattctg cgcctgcctc gtcccctcag ctttcacacg atgatactca   1860

ttcacgcatt gaacattatg ctagcaggct agcagaaatg gaaaacagca atggatctta   1920

tctaaatgat agcatctctc ctaatgagag catagatgat gaacatttgt taatccagca   1980

ttactgccaa agtttgaacc aggactcccc cctgagccag cctcgtagtc ctgcccagat   2040

cttgatttcc ttagagagtg aggaaagagg ggagctagag agaatcctag cagatcttga   2100

ggaagaaaac aggaatctgc aagcagaata tgaccgtcta aagcagcagc acgaacataa   2160

aggcctgtcc ccactgccgt cccctcctga aatgatgccc acctctcccc agagtccccg   2220

ggatgctgag ctcattgctg aggccaagct actgcgtcaa cacaaaggcc gcctggaagc   2280

caggatgcaa atcctggaag accacaataa acagctggag tcacagttac acaggctaag   2340

gcagctgctg gagcaacccc aggcagaggc caaagtgaat ggcacaacgg tgtcctctcc   2400

ttctacctct ctacagaggt ccgacagcag tcagcctatg ctgctccgag tggttggcag   2460

tcaaacttcg gactccatgg gtgaggaaga tcttctcagt cctccccagg acacaagcac   2520

agggttagag gaggtgatgg agcaactcaa caactccttc cctagttcaa gaggaagaaa   2580

tacccctgga aagccaatga gagaggacac aatgtag                            2617


<210>  72
<211>  137
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<223>  Human sequence of the dystrophin gene DMD, exon 70

<400>  72
actacatcag gagaagatgt tcgagacttt gccaaggtac taaaaaacaa atttcgaacc     60

aaaaggtatt ttgcgaagca tccccgaatg ggctacctgc cagtgcagac tgtcttagag    120

ggggacaaca tggaaac                                                   137


<210>  73
<211>  137
<212>  DNA
<213>  Mus musculus


<220>
<221>  misc_feature
<223>  Murine sequence of the dystrophin gene DMD, exon 70

<400>  73
actacatccg gagaagatgt tcgcgacttc gccaaggtac taaaaaacaa atttcgaacc     60

aaaaggtatt ttgcgaagca tccccgaatg ggctacctgc cagtgcagac tgtgttagag    120

ggggacaaca tggaaac                                                   137


