                         SEQUENCE LISTING

<110>  PIERRE FABRE MEDICAMENT
 
<120>  New chimeric antibodies and their uses for the treatment of 
       cancer

<130>  D28060

<150>  EP 09305964.0
<151>  2009-10-09

<150>  US 61/266,020
<151>  2009-12-02

<160>  85    

<170>  PatentIn version 3.3

<210>  1
<211>  10
<212>  PRT
<213>  mus musculus

<400>  1

Ala Ser Val Glu Tyr Tyr Gly Thr Ser Leu 
1               5                   10  


<210>  2
<211>  3
<212>  PRT
<213>  mus musculus

<400>  2

Glu Ala Ser 
1           


<210>  3
<211>  9
<212>  PRT
<213>  mus musculus

<400>  3

Gln Gln Ser Arg Lys Ala Pro Tyr Thr 
1               5                   


<210>  4
<211>  8
<212>  PRT
<213>  mus musculus

<400>  4

Gly Phe Thr Phe Ser Thr Tyr Thr 
1               5               


<210>  5
<211>  8
<212>  PRT
<213>  mus musculus

<400>  5

Ile Ser Ser Gly Gly Gly Thr Thr 
1               5               


<210>  6
<211>  11
<212>  PRT
<213>  mus musculus

<400>  6

Ala Thr Pro Arg Ile Gly Thr Gly Phe Ala Tyr 
1               5                   10      


<210>  7
<211>  218
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chimeric anti-CD151 antibody light chain derived from the murine 
       203B6 monoclonal antibody

<400>  7

Asp Ile Val Leu Ser Gln Ser Pro Ala Ser Leu Ala Leu Ser Leu Gly 
1               5                   10                  15      

Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Ala Ser Val Glu Tyr Tyr 
            20                  25                  30          

Gly Thr Ser Leu Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              

Lys Leu Leu Ile Tyr Glu Ala Ser Asn Val Glu Ser Gly Val Pro Ala 
    50                  55                  60                  

Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  

Pro Val Glu Glu Asp Asp Leu Ala Ile Tyr Phe Cys Gln Gln Ser Arg 
                85                  90                  95      

Lys Ala Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         

Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
        115                 120                 125             

Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
    130                 135                 140                 

Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
145                 150                 155                 160 

Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
                165                 170                 175     

Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
            180                 185                 190         

His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
        195                 200                 205             

Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215             


<210>  8
<211>  448
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chimeric anti-CD151 antibody heavy chain derived from the murine 
       203B6 monoclonal antibody

<400>  8

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          

Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              

Ala Tyr Ile Ser Ser Gly Gly Gly Thr Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      

Ala Thr Pro Arg Ile Gly Thr Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         

Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             

Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly 
    130                 135                 140                 

Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 

Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     

Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         

Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro Ser 
        195                 200                 205             

Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys Thr 
    210                 215                 220                 

His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
225                 230                 235                 240 

Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     

Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         

Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             

Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
    290                 295                 300                 

Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 

Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
                325                 330                 335     

Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         

Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             

Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 

Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
385                 390                 395                 400 

Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     

Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         

Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  9
<211>  445
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chimeric anti-CD151 antibody heavy chain derived from the murine 
       203B6 monoclonal antibody

<400>  9

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      

Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Thr Tyr 
            20                  25                  30          

Thr Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              

Ala Tyr Ile Ser Ser Gly Gly Gly Thr Thr Tyr Tyr Pro Asp Thr Val 
    50                  55                  60                  

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Thr Leu Tyr 
65                  70                  75                  80  

Leu Gln Met Asn Ser Leu Lys Ser Glu Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      

Ala Thr Pro Arg Ile Gly Thr Gly Phe Ala Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         

Leu Val Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro 
        115                 120                 125             

Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly 
    130                 135                 140                 

Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn 
145                 150                 155                 160 

Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln 
                165                 170                 175     

Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser 
            180                 185                 190         

Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser 
        195                 200                 205             

Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys 
    210                 215                 220                 

Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     

Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln 
            260                 265                 270         

Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             

Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 

Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 

Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     

Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         

Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             

Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 

Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 

Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     

Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         

His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445 


<210>  10
<211>  30
<212>  DNA
<213>  mus musculus

<400>  10
gccagtgttg aatattatgg cacaagttta                                      30


<210>  11
<211>  9
<212>  DNA
<213>  mus musculus

<400>  11
gaagcatcc                                                              9


<210>  12
<211>  27
<212>  DNA
<213>  mus musculus

<400>  12
cagcaaagta ggaaggctcc ttacacg                                         27


<210>  13
<211>  24
<212>  DNA
<213>  mus musculus

<400>  13
ggattcactt tcagtaccta tacc                                            24


<210>  14
<211>  24
<212>  DNA
<213>  mus musculus

<400>  14
attagtagtg gtggtggtac tacc                                            24


<210>  15
<211>  33
<212>  DNA
<213>  mus musculus

<400>  15
gcaactcccc gaattgggac ggggtttgct tac                                  33


<210>  16
<211>  654
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chimeric  anti-CD151 antibody light chain derived from the murine
       203B6 monoclonal antibody

<400>  16
gacatcgtgc tgtcccagag ccccgcctct ctggccctga gcctgggaca gcgggccacc     60

atctcttgcc gggccagcgc cagcgtggag tactacggca ccagcctgat gcactggtat    120

cagcagaagc ccggccagcc ccccaagctg ctgatctacg aggccagcaa cgtggagagc    180

ggcgtgcccg ccagattcag cggcagcggc tccggcaccg acttcagcct gaacatccac    240

cccgtggaag aggacgacct ggccatctac ttttgccagc agagccggaa ggccccctac    300

acctttggcg gcggaacaaa gctggaaatc aagcgtacgg tggccgctcc cagcgtgttc    360

atcttccccc caagcgacga gcagctgaag agcggcaccg ccagcgtggt gtgtctgctg    420

aacaacttct accccaggga ggccaaggtg cagtggaagg tggacaacgc cctgcagagc    480

ggcaacagcc aggagagcgt caccgagcag gacagcaagg actccaccta cagcctgagc    540

agcaccctga ccctgagcaa ggccgactac gagaagcaca aggtgtacgc ctgtgaggtg    600

acccaccagg gcctgtccag ccccgtgacc aagagcttca acaggggcga gtgc          654


<210>  17
<211>  1344
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chimeric anti-CD151 antibody heavy chain derived from the murine 
       203B6 monoclonal antibody

<400>  17
gaagtgaaac tggtggagtc tggcggcgga ctggtgcagc caggcggcag cctgaagctg     60

tcctgcgccg ccagcggctt caccttcagc acctacacca tgagctgggt gcgccagacc    120

cccgagaagc ggctggaatg ggtggcctac atcagcagcg gcggagggac cacctactac    180

cccgacaccg tgaagggccg gttcaccatc agccgggaca acgcccggaa caccctgtac    240

ctgcagatga acagcctgaa gtccgaggac accgccatgt actactgcgc caccccccgg    300

atcggcaccg gcttcgccta ctggggccag ggcaccctgg tgaccgtgtc cgccgccagc    360

accaagggcc caagcgtgtt cccgctagcc cccagcagca agagcaccag cggcggcaca    420

gccgccctgg gctgcctggt gaaggactac ttccccgagc ccgtgaccgt gtcctggaac    480

agcggagccc tgacctccgg cgtgcacacc ttccccgccg tgctgcagag cagcggcctg    540

tacagcctga gcagcgtggt gaccgtgccc agcagcagcc tgggcaccca gacctacatc    600

tgtaacgtga accacaagcc cagcaacacc aaggtggaca agagagtgga gcccaagagc    660

tgtgacaaga cccacacctg ccccccctgc ccagcccccg agctgctggg cggacccagc    720

gtgttcctgt tcccccccaa gcccaaggac accctgatga tcagcagaac ccccgaggtg    780

acctgtgtgg tggtggacgt gtcccacgag gacccagagg tgaagttcaa ctggtacgtg    840

gacggcgtgg aggtgcacaa cgccaagacc aagcccagag aggagcagta caacagcacc    900

tacagggtgg tgtccgtgct gaccgtgctg caccaggact ggctgaacgg caaggagtac    960

aagtgtaagg tgtccaacaa ggccctgcca gccccaatcg aaaagaccat cagcaaggcc   1020

aagggccagc caagagagcc ccaggtgtac accctgccac ccagcaggga ggagatgacc   1080

aagaaccagg tgtccctgac ctgtctggtg aagggcttct acccaagcga catcgccgtg   1140

gagtgggaga gcaacggcca gcccgagaac aactacaaga ccaccccccc agtgctggac   1200

agcgacggca gcttcttcct gtacagcaag ctgaccgtgg acaagagcag atggcagcag   1260

ggcaacgtgt tcagctgctc cgtgatgcac gaggccctgc acaaccacta cacccagaag   1320

agcctgagcc tgtccccagg caag                                          1344


<210>  18
<211>  1335
<212>  DNA
<213>  Artificial sequence

<220>
<223>   Chimeric anti-CD151 antibody heavy chain derived from the murine
       203B6 monoclonal antibody

<400>  18
gaagtgaaac tggtggagtc tggcggcgga ctggtgcagc caggcggcag cctgaagctg     60

tcctgcgccg ccagcggctt caccttcagc acctacacca tgagctgggt gcgccagacc    120

cccgagaagc ggctggaatg ggtggcctac atcagcagcg gcggagggac cacctactac    180

cccgacaccg tgaagggccg gttcaccatc agccgggaca acgcccggaa caccctgtac    240

ctgcagatga acagcctgaa gtccgaggac accgccatgt actactgcgc caccccccgg    300

atcggcaccg gcttcgccta ctggggccag ggcaccctgg tgaccgtgtc cgccgccagc    360

accaagggcc caagcgtgtt ccccctggcc ccctgctcca gaagcaccag cgagagcaca    420

gccgccctgg gctgcctggt gaaggactac ttccccgagc ccgtgaccgt gtcctggaac    480

agcggagccc tgaccagcgg cgtgcacacc ttccccgccg tgctgcagag cagcggcctg    540

tacagcctga gcagcgtggt gaccgtgccc agcagcagcc tgggcaccaa gacctacacc    600

tgtaacgtgg accacaagcc cagcaacacc aaggtggaca agagggtgga gagcaagtac    660

ggcccaccct gccccagctg cccagccccc gagttcctgg gcggacccag cgtgttcctg    720

ttccccccca agcccaagga caccctgatg atcagcagaa cccccgaggt gacctgtgtg    780

gtggtggacg tgtcccagga ggaccccgag gtccagttca actggtacgt ggacggcgtg    840

gaggtgcaca acgccaagac caagcccaga gaggagcagt ttaacagcac ctaccgggtg    900

gtgtccgtgc tgaccgtgct gcaccaggac tggctgaacg gcaaagagta caagtgtaag    960

gtctccaaca agggcctgcc aagcagcatc gaaaagacca tcagcaaggc caagggccag   1020

cctagagagc cccaggtcta caccctgcca cccagccaag aggagatgac caagaaccag   1080

gtgtccctga cctgtctggt gaagggcttc tacccaagcg acatcgccgt ggagtgggag   1140

agcaacggcc agcccgagaa caactacaag accacccccc cagtgctgga cagcgacggc   1200

agcttcttcc tgtacagcag gctgaccgtg gacaagtcca gatggcagga gggcaacgtc   1260

tttagctgct ccgtgatgca cgaggccctg cacaaccact acacccagaa gagcctgagc   1320

ctgtccctgg gcaag                                                    1335


<210>  19
<211>  6
<212>  PRT
<213>  mus musculus

<400>  19

Glu Asn Val Gly Thr Tyr 
1               5       


<210>  20
<211>  3
<212>  PRT
<213>  mus musculus

<400>  20

Gly Ala Ser 
1           


<210>  21
<211>  9
<212>  PRT
<213>  mus musculus

<400>  21

Gly Gln Thr Tyr Ser Phe Pro Tyr Thr 
1               5                   


<210>  22
<211>  8
<212>  PRT
<213>  mus musculus

<400>  22

Gly Tyr Thr Phe Thr Ser Ser Ser 
1               5               


<210>  23
<211>  8
<212>  PRT
<213>  mus musculus

<400>  23

Ile His Pro Asn Ser Gly Asn Thr 
1               5               


<210>  24
<211>  12
<212>  PRT
<213>  mus musculus

<400>  24

Ala Arg Ala Arg Ser Phe Tyr Tyr Ala Met Asp Cys 
1               5                   10          


<210>  25
<211>  214
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chimeric anti-CD151 antibody light chain derived from the murine 
       214B2 monoclonal antibody

<400>  25

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      

Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          

Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  

Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  

Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Thr Tyr Ser Phe Pro Tyr 
                85                  90                  95      

Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             

Phe Asn Arg Gly Glu Cys 
    210                 


<210>  26
<211>  449
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chimeric anti-CD151 antibody heavy chain derived from the murine 
       214B2 monoclonal antibody

<400>  26

Gln Val Gln Leu Gln Gln Pro Gly Ser Val Leu Val Arg Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          

Ser Met His Trp Ala Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              

Gly Glu Ile His Pro Asn Ser Gly Asn Thr Asn Asn Asn Glu Lys Phe 
    50                  55                  60                  

Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  

Val Asp Leu Ser Ser Leu Ser Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Ala Arg Ser Phe Tyr Tyr Ala Met Asp Cys Trp Gly Gln Gly 
            100                 105                 110         

Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             

Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 

Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 

Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     

Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         

Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             

Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 

Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 

Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     

Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         

Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             

Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 

Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 

Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     

Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         

Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             

Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 

Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 

Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     

Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         

Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             

Lys 
    


<210>  27
<211>  446
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Chimeric anti-CD151 antibody heavy chain derived from the murine 
       214B2 monoclonal antibody

<400>  27

Gln Val Gln Leu Gln Gln Pro Gly Ser Val Leu Val Arg Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          

Ser Met His Trp Ala Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              

Gly Glu Ile His Pro Asn Ser Gly Asn Thr Asn Asn Asn Glu Lys Phe 
    50                  55                  60                  

Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  

Val Asp Leu Ser Ser Leu Ser Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Ala Arg Ser Phe Tyr Tyr Ala Met Asp Cys Trp Gly Gln Gly 
            100                 105                 110         

Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             

Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 

Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 

Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     

Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         

Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             

Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro 
    210                 215                 220                 

Cys Pro Ser Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe 
225                 230                 235                 240 

Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     

Glu Val Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val 
            260                 265                 270         

Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             

Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val 
    290                 295                 300                 

Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 

Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser 
                325                 330                 335     

Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         

Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             

Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 

Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp 
385                 390                 395                 400 

Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     

Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         

Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
        435                 440                 445     


<210>  28
<211>  18
<212>  DNA
<213>  mus musculus

<400>  28
gagaatgtgg gtacttat                                                   18


<210>  29
<211>  9
<212>  DNA
<213>  mus musculus

<400>  29
ggggcatcc                                                              9


<210>  30
<211>  27
<212>  DNA
<213>  mus musculus

<400>  30
ggacagactt acagctttcc gtacacg                                         27


<210>  31
<211>  24
<212>  DNA
<213>  mus musculus

<400>  31
ggctacacct tcaccagctc ctcg                                            24


<210>  32
<211>  24
<212>  DNA
<213>  mus musculus

<400>  32
attcatccta atagtggtaa tact                                            24


<210>  33
<211>  36
<212>  DNA
<213>  mus musculus

<400>  33
gcaagggcga ggtcctttta ctatgctatg gactgc                               36


<210>  34
<211>  642
<212>  DNA
<213>  Artificial sequence

<220>
<223>   Chimeric anti-CD151 antibody light chain derived from the murine
       214B2 monoclonal antibody

<400>  34
aacatcgtga tgacccagag ccccaagagc atgagcatga gcgtgggcga gagagtgacc     60

ctgagctgca aggccagcga gaacgtgggc acctacgtgt cctggtatca gcagaagccc    120

gagcagtccc ccaagctgct gatctacggc gccagcaacc ggtacaccgg cgtgcccgac    180

agattcaccg gcagcggcag cgccaccgac ttcaccctga ccatcagcag cgtgcaggcc    240

gaggacctgg ccgactacca ctgcggccag acctacagct tcccctacac ctttggcggc    300

ggaacaaagc tggaaatcaa gcgtacggtg gccgctccca gcgtgttcat cttcccccca    360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac    420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag    480

gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc    540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc    600

ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gc                       642


<210>  35
<211>  1347
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chimeric anti-CD151 antibody heavy chain derived from the murine 
       214B2 monoclonal antibody

<400>  35
caggtgcagc tgcagcagcc cggcagcgtg ctggtgagac ctggcgcctc cgtgaagctg     60

tcctgcaagg cctccggcta caccttcacc agcagcagca tgcactgggc caagcagcgg    120

ccaggccagg gactggaatg gatcggcgag atccacccca acagcggcaa caccaacaac    180

aacgagaagt tcaagggcaa ggccaccctg accgtggaca ccagcagctc caccgcctac    240

gtggacctga gcagcctgtc cagcgaggac agcgccgtgt actactgcgc cagagccaga    300

tccttctact acgctatgga ctgctggggc cagggcacca gcgtgaccgt gtccagcgcc    360

agcaccaagg gcccaagcgt gttcccgcta gcccccagca gcaagagcac cagcggcggc    420

acagccgccc tgggctgcct ggtgaaggac tacttccccg agcccgtgac cgtgtcctgg    480

aacagcggag ccctgacctc cggcgtgcac accttccccg ccgtgctgca gagcagcggc    540

ctgtacagcc tgagcagcgt ggtgaccgtg cccagcagca gcctgggcac ccagacctac    600

atctgtaacg tgaaccacaa gcccagcaac accaaggtgg acaagagagt ggagcccaag    660

agctgtgaca agacccacac ctgccccccc tgcccagccc ccgagctgct gggcggaccc    720

agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagcag aacccccgag    780

gtgacctgtg tggtggtgga cgtgtcccac gaggacccag aggtgaagtt caactggtac    840

gtggacggcg tggaggtgca caacgccaag accaagccca gagaggagca gtacaacagc    900

acctacaggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggag    960

tacaagtgta aggtgtccaa caaggccctg ccagccccaa tcgaaaagac catcagcaag   1020

gccaagggcc agccaagaga gccccaggtg tacaccctgc cacccagcag ggaggagatg   1080

accaagaacc aggtgtccct gacctgtctg gtgaagggct tctacccaag cgacatcgcc   1140

gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc cccagtgctg   1200

gacagcgacg gcagcttctt cctgtacagc aagctgaccg tggacaagag cagatggcag   1260

cagggcaacg tgttcagctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag   1320

aagagcctga gcctgtcccc aggcaag                                       1347


<210>  36
<211>  1338
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Chimeric anti-CD151 antibody heavy chain derived from the murine 
       214B2 monoclonal antibody

<400>  36
caggtgcagc tgcagcagcc cggcagcgtg ctggtgagac ctggcgcctc cgtgaagctg     60

tcctgcaagg cctccggcta caccttcacc agcagcagca tgcactgggc caagcagcgg    120

ccaggccagg gactggaatg gatcggcgag atccacccca acagcggcaa caccaacaac    180

aacgagaagt tcaagggcaa ggccaccctg accgtggaca ccagcagctc caccgcctac    240

gtggacctga gcagcctgtc cagcgaggac agcgccgtgt actactgcgc cagagccaga    300

tccttctact acgctatgga ctgctggggc cagggcacca gcgtgaccgt gtccagcgcc    360

agcaccaagg gcccaagcgt gttccccctg gccccctgct ccagaagcac cagcgagagc    420

acagccgccc tgggctgcct ggtgaaggac tacttccccg agcccgtgac cgtgtcctgg    480

aacagcggag ccctgaccag cggcgtgcac accttccccg ccgtgctgca gagcagcggc    540

ctgtacagcc tgagcagcgt ggtgaccgtg cccagcagca gcctgggcac caagacctac    600

acctgtaacg tggaccacaa gcccagcaac accaaggtgg acaagagggt ggagagcaag    660

tacggcccac cctgccccag ctgcccagcc cccgagttcc tgggcggacc cagcgtgttc    720

ctgttccccc ccaagcccaa ggacaccctg atgatcagca gaacccccga ggtgacctgt    780

gtggtggtgg acgtgtccca ggaggacccc gaggtccagt tcaactggta cgtggacggc    840

gtggaggtgc acaacgccaa gaccaagccc agagaggagc agtttaacag cacctaccgg    900

gtggtgtccg tgctgaccgt gctgcaccag gactggctga acggcaaaga gtacaagtgt    960

aaggtctcca acaagggcct gccaagcagc atcgaaaaga ccatcagcaa ggccaagggc   1020

cagcctagag agccccaggt ctacaccctg ccacccagcc aagaggagat gaccaagaac   1080

caggtgtccc tgacctgtct ggtgaagggc ttctacccaa gcgacatcgc cgtggagtgg   1140

gagagcaacg gccagcccga gaacaactac aagaccaccc ccccagtgct ggacagcgac   1200

ggcagcttct tcctgtacag caggctgacc gtggacaagt ccagatggca ggagggcaac   1260

gtctttagct gctccgtgat gcacgaggcc ctgcacaacc actacaccca gaagagcctg   1320

agcctgtccc tgggcaag                                                 1338


<210>  37
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  (TH7) chimeric anti-CD151 antibody light chain derived from the 
       murine 214B2 monoclonal antibody

<400>  37

Asn Ile Val Met Thr Gln Ser Pro Lys Ser Met Ser Met Ser Val Gly 
1               5                   10                  15      

Glu Arg Val Thr Leu Ser Cys Lys Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          

Val Ser Trp Tyr Gln Gln Lys Pro Glu Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  

Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Val Gln Ala 
65                  70                  75                  80  

Glu Asp Leu Ala Asp Tyr His Cys Gly Gln Thr Tyr Ser Phe Pro Tyr 
                85                  90                  95      

Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             

Phe Asn Arg Gly Glu Cys 
    210                 


<210>  38
<211>  447
<212>  PRT
<213>  Artificial

<220>
<223>  (TH7) chimeric anti-CD151 antibody heavy chain derived from the 
       murine 214B2 monoclonal antibody

<400>  38

Gln Val Gln Leu Gln Gln Pro Gly Ser Val Leu Val Arg Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          

Ser Met His Trp Ala Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              

Gly Glu Ile His Pro Asn Ser Gly Asn Thr Asn Asn Asn Glu Lys Phe 
    50                  55                  60                  

Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  

Val Asp Leu Ser Ser Leu Ser Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Ala Arg Ser Phe Tyr Tyr Ala Met Asp Cys Trp Gly Gln Gly 
            100                 105                 110         

Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             

Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 

Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 

Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     

Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         

Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             

Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Cys 
    210                 215                 220                 

His Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val 
225                 230                 235                 240 

Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr 
                245                 250                 255     

Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu 
            260                 265                 270         

Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys 
        275                 280                 285             

Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser 
    290                 295                 300                 

Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys 
305                 310                 315                 320 

Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile 
                325                 330                 335     

Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro 
            340                 345                 350         

Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu 
        355                 360                 365             

Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn 
    370                 375                 380                 

Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser 
385                 390                 395                 400 

Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg 
                405                 410                 415     

Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu 
            420                 425                 430         

His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445         


<210>  39
<211>  645
<212>  DNA
<213>  Artificial

<220>
<223>  DNA coding the (TH7) chimeric anti-CD151 antibody light chain 
       derived from the murine 214B2 monoclonal antibody

<400>  39
aacatcgtga tgacccagag ccccaagagc atgagcatga gcgtgggcga gagagtgacc     60

ctgagctgca aggccagcga gaacgtgggc acctacgtgt cctggtatca gcagaagccc    120

gagcagtccc ccaagctgct gatctacggc gccagcaacc ggtacaccgg cgtgcccgac    180

agattcaccg gcagcggcag cgccaccgac ttcaccctga ccatcagcag cgtgcaggcc    240

gaggacctgg ccgactacca ctgcggccag acctacagct tcccctacac ctttggcggc    300

ggaacaaagc tggaaatcaa gcgtacggtg gccgctccca gcgtgttcat cttcccccca    360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac    420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag    480

gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc    540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc    600

ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gctga                    645


<210>  40
<211>  1344
<212>  DNA
<213>  Artificial

<220>
<223>  DNA coding the (TH7) chimeric anti-CD151 antibody heavy chain 
       derived from the murine 214B2 monoclonal antibody

<400>  40
caggtgcagc tgcagcagcc cggcagcgtg ctggtgagac ctggcgcctc cgtgaagctg     60

tcctgcaagg cctccggcta caccttcacc agcagcagca tgcactgggc caagcagcgg    120

ccaggccagg gactggaatg gatcggcgag atccacccca acagcggcaa caccaacaac    180

aacgagaagt tcaagggcaa ggccaccctg accgtggaca ccagcagctc caccgcctac    240

gtggacctga gcagcctgtc cagcgaggac agcgccgtgt actactgcgc cagagccaga    300

tccttctact acgctatgga ctgctggggc cagggcacca gcgtgaccgt gtccagcgcc    360

agcaccaagg gcccaagcgt gttcccgcta gccccgtctt caaagagtac ctcaggcgga    420

actgccgctc ttggttgcct tgtgaaggac tattttcctg agcccgtgac ggtcagctgg    480

aactctggcg cactgactag cggcgtacac acattccctg cggtgctcca aagttccggg    540

ctgtactcac tgtcctccgt tgtgaccgtt ccatctagtt ccctcgggac acagacatac    600

atctgtaatg tgaatcataa gccttcaaac accaaggtcg acaaacgggt cgagcccaaa    660

agctgcgatt gccactgtcc tccatgtcca gcccccgaac tgttgggcgg accgagcgtg    720

ttcttgtttc cacccaagcc caaagatacc ctcatgatca gcagaacccc cgaggtgacc    780

tgtgtggtgg tggacgtgtc ccacgaggac ccagaggtga agttcaactg gtacgtggac    840

ggcgtggagg tgcacaacgc caagaccaag cccagagagg agcagtacaa cagcacctac    900

agggtggtgt ccgtgctgac cgtgctgcac caggactggc tgaacggcaa ggagtacaag    960

tgtaaggtgt ccaacaaggc cctgccagcc ccaatcgaaa agaccatcag caaggccaag   1020

ggccagccaa gagagcccca ggtgtacacc ctgccaccca gcagggagga gatgaccaag   1080

aaccaggtgt ccctgacctg tctggtgaag ggcttctacc caagcgacat cgccgtggag   1140

tgggagagca acggccagcc cgagaacaac tacaagacca cccccccagt gctggacagc   1200

gacggcagct tcttcctgta cagcaagctg accgtggaca agagcagatg gcagcagggc   1260

aacgtgttca gctgctccgt gatgcacgag gccctgcaca accactacac ccagaagagc   1320

ctgagcctgt ccccaggcaa gtga                                          1344


<210>  41
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Engineered TH7 Hinge region

<400>  41

Pro Lys Ser Cys Asp Cys His Cys Pro Pro Cys Pro 
1               5                   10          


<210>  42
<211>  14
<212>  PRT
<213>  Artificial

<220>
<223>  Human IgG1 Hinge region

<400>  42

Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
1               5                   10                  


<210>  43
<211>  12
<212>  PRT
<213>  Artificial

<220>
<223>  Mouse IgG1 Hinge region

<400>  43

Pro Arg Asp Cys Gly Cys Lys Pro Cys Ile Cys Thr 
1               5                   10          


<210>  44
<211>  463
<212>  PRT
<213>  Artificial

<220>
<223>  c214B2[IgG2]

<400>  44

Met Gly Trp Ser Cys Ile Met Phe Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      

Val His Ser Gln Val Gln Leu Gln Gln Pro Gly Ser Val Leu Val Arg 
            20                  25                  30          

Pro Gly Ala Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              

Thr Ser Ser Ser Met His Trp Ala Lys Gln Arg Pro Gly Gln Gly Leu 
    50                  55                  60                  

Glu Trp Ile Gly Glu Ile His Pro Asn Ser Gly Asn Thr Asn Asn Asn 
65                  70                  75                  80  

Glu Lys Phe Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser 
                85                  90                  95      

Thr Ala Tyr Val Asp Leu Ser Ser Leu Ser Ser Glu Asp Ser Ala Val 
            100                 105                 110         

Tyr Tyr Cys Ala Arg Ala Arg Ser Phe Tyr Tyr Ala Met Asp Cys Trp 
        115                 120                 125             

Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 

Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
145                 150                 155                 160 

Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     

Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         

Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             

Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp 
    210                 215                 220                 

His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys 
225                 230                 235                 240 

Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
                245                 250                 255     

Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         

Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             

Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 

Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val 
305                 310                 315                 320 

Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     

Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         

Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             

Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 

Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 

Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp 
                405                 410                 415     

Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         

Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             

Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
    450                 455                 460             


<210>  45
<211>  1389
<212>  DNA
<213>  Artificial

<220>
<223>  c214B2[IgG2]

<400>  45
atgggctggt cctgcatcat gttctttctg gtggctaccg ccaccggcgt gcacagccag     60

gtgcagctgc agcagcccgg cagcgtgctg gtgagacctg gcgcctccgt gaagctgtcc    120

tgcaaggcct ccggctacac cttcaccagc agcagcatgc actgggccaa gcagcggcca    180

ggccagggac tggaatggat cggcgagatc caccccaaca gcggcaacac caacaacaac    240

gagaagttca agggcaaggc caccctgacc gtggacacca gcagctccac cgcctacgtg    300

gacctgagca gcctgtccag cgaggacagc gccgtgtact actgcgccag agccagatcc    360

ttctactacg ctatggactg ctggggccag ggcaccagcg tgaccgtgtc cagcgccagc    420

accaagggcc caagcgtgtt cccgctagcg ccctgctcca gaagcaccag cgagagcaca    480

gccgccctgg gctgcctggt gaaggactac ttccccgagc ccgtgaccgt gtcctggaac    540

agcggagccc tgaccagcgg cgtgcacacc ttccccgccg tgctgcagag cagcggcctg    600

tacagcctga gcagcgtggt gaccgtgcca agcagcaact tcggcaccca gacctacacc    660

tgtaacgtgg accacaagcc cagcaacacc aaggtggaca agaccgtgga gaggaagtgc    720

tgtgtggagt gccccccctg cccagccccc ccagtggccg gacccagcgt gttcctgttc    780

ccccccaagc ccaaggacac cctgatgatc agcagaaccc ccgaggtgac ctgtgtggtg    840

gtggacgtgt cccacgagga ccccgaggtg cagttcaact ggtacgtgga cggcgtggag    900

gtgcacaacg ccaagaccaa gcccagagag gagcagttta acagcacctt ccgggtggtg    960

tccgtgctga ccgtggtgca ccaggactgg ctgaacggca aggagtacaa gtgtaaggtc   1020

tccaacaagg gcctgccagc ccccatcgaa aagaccatca gcaagaccaa gggacagcca   1080

agagagccac aggtctacac cctgcccccc agcagggagg agatgaccaa gaaccaggtg   1140

tccctgacct gtctggtgaa gggcttctac ccaagcgaca tcgccgtgga gtgggagagc   1200

aacggccagc ccgagaacaa ctacaagacc acccccccaa tgctggacag cgacggcagc   1260

ttcttcctgt acagcaagct gacagtggac aagagcagat ggcagcaggg caacgtgttc   1320

agctgctccg tgatgcacga ggccctgcac aaccactaca cccagaagag cctgagcctg   1380

tccccaggc                                                           1389


<210>  46
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  hz214B2 Light Chain Variable domain Var1

<400>  46

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Thr Tyr Ser Phe Pro Tyr 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  47
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  hz214B2 Light Chain Variable domain Var 2

<400>  47

Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          

Val Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Gly Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Thr Tyr Ser Phe Pro Tyr 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  48
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  hz214B2 Light Chain Variable domain Var 3

<400>  48

Asn Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          

Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Gly Ala Ser Asn Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Thr Tyr His Cys Gly Gln Thr Tyr Ser Phe Pro Tyr 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  49
<211>  107
<212>  PRT
<213>  Artificial

<220>
<223>  hz214B2 Light Chain Variable domain Var 4

<400>  49

Asn Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          

Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Thr Tyr His Cys Gly Gln Thr Tyr Ser Phe Pro Tyr 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  50
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  hz214B2 Heavy Chain Variable domain Var1

<400>  50

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          

Ser Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              

Gly Trp Ile His Pro Asn Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  

Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  

Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Ala Arg Ser Phe Tyr Tyr Ala Met Asp Cys Trp Gly Gln Gly 
            100                 105                 110         

Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  51
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  hz214B2 Heavy Chain Variable domain Var 2

<400>  51

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          

Ser Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              

Gly Glu Ile His Pro Asn Ser Gly Asn Thr Asn Asn Ala Gln Lys Phe 
    50                  55                  60                  

Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  

Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Ala Arg Ser Phe Tyr Tyr Ala Met Asp Cys Trp Gly Gln Gly 
            100                 105                 110         

Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  52
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  hz214B2 Heavy Chain Variable domain Var 3

<400>  52

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          

Ser Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              

Gly Glu Ile His Pro Asn Ser Gly Asn Thr Asn Asn Ala Gln Lys Phe 
    50                  55                  60                  

Gln Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  

Val Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Ala Arg Ser Phe Tyr Tyr Ala Met Asp Cys Trp Gly Gln Gly 
            100                 105                 110         

Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  53
<211>  119
<212>  PRT
<213>  Artificial

<220>
<223>  hz214B2 Heavy Chain Variable domain Var 4

<400>  53

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          

Ser Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              

Gly Glu Ile His Pro Asn Ser Gly Asn Thr Asn Asn Asn Glu Lys Phe 
    50                  55                  60                  

Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  

Val Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Ala Arg Ser Phe Tyr Tyr Ala Met Asp Cys Trp Gly Gln Gly 
            100                 105                 110         

Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  54
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  hz214B2 Light Chain Variable domain Var1

<400>  54
gacatccaga tgacccagtc cccctccagc ctgtccgcct ctgtgggcga cagagtgacc     60

atcacctgtc gggcctccga gaacgtgggc acctacctga actggtacca gcagaagccc    120

ggcaaggccc ccaagctgct gatctacggc gccagctccc tgcagtccgg cgtgccctcc    180

agattctccg gctctggctc cggcaccgac tttaccctga ccatctccag cctgcagccc    240

gaggacttcg ccacctacta ctgcggccag acctactcct tcccctacac cttcggccag    300

ggcaccaagc tggaaatcaa g                                              321


<210>  55
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  hz214B2 Light Chain Variable domain Var 2

<400>  55
aacatccaga tgacccagtc cccctccagc ctgtccgcct ctgtgggcga cagagtgacc     60

atcacctgtc gggcctccga gaacgtgggc acctacgtga actggtacca gcagaagccc    120

ggcaaggccc ccaagctgct gatctacggc gcctccaacc tgcagtccgg cgtgccctcc    180

cggttctctg gctctggctc cgccaccgac tttaccctga ccatctccag cctgcagccc    240

gaggacttcg ccacctacta ctgcggccag acctactcct tcccctacac cttcggccag    300

ggcaccaagc tggaaatcaa g                                              321


<210>  56
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  hz214B2 Light Chain Variable domain Var 3

<400>  56
aacatcgtga tgacccagtc cccctccagc ctgtccgcct ctgtgggcga cagagtgacc     60

atcacatgca aggcctccga gaacgtgggc acctacgtgt cctggtacca gcagaagccc    120

ggcaaggccc ccaagctgct gatctacggc gcctccaacc tgtactccgg cgtgccctcc    180

cggttctccg gctctggctc tgccaccgac tttaccctga ccatctccag cctgcagccc    240

gaggacttcg ccacctacca ctgcggccag acctactcct tcccctacac cttcggccag    300

ggcaccaagc tggaaatcaa g                                              321


<210>  57
<211>  321
<212>  DNA
<213>  Artificial

<220>
<223>  hz214B2 Light Chain Variable domain Var 4

<400>  57
aacatcgtga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga ccgggtgacc     60

atcacctgca aggctagcga gaacgtcggc acctacgtgt cctggtacca gcagaagccc    120

ggcaaggccc ccaagctgct gatctacggc gccagcaacc gctacaccgg cgtgcccagc    180

cggttcagcg gcagcggcag cgccaccgac ttcaccctga ccatcagcag cctgcagccc    240

gaggacttcg ccacctacca ctgcgggcag acctacagct tcccctacac cttcggccag    300

ggcaccaagc tggagatcaa g                                              321


<210>  58
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  hz214B2 Heavy Chain Variable domain Var1

<400>  58
caggtgcagc tggtgcagtc cggcgctgaa gtgaagaaac ccggcgcttc cgtgaaggtg     60

tcctgcaagg cctccggcta caccttcacc tccagctcca tgcactgggt gcgacaggcc    120

cctggacagg gcctggaatg gatgggctgg attcacccca actccggcaa caccaactac    180

gcccagaaat tccagggcag agtgaccatg acccgggaca cctccatctc caccgcctac    240

atggaactgt cccggctgcg gagcgacgac accgccgtgt actactgcgc cagagcccgg    300

tccttctact acgccatgga ctgctggggc cagggcacct ctgtgaccgt gtcctcc       357


<210>  59
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  hz214B2 Heavy Chain Variable domain Var 2

<400>  59
caggtgcagc tggtgcagtc cggcgctgaa gtgaagaaac ccggcgcttc cgtgaaggtg     60

tcctgcaagg cctccggcta caccttcacc tccagctcca tgcactgggt gcgacaggcc    120

cctggacagg gcctggaatg gatgggcgag attcacccca actccggcaa caccaacaac    180

gcccagaaat tccagggcag agtgaccctg accgtggaca cctccatctc caccgcctac    240

atggaactgt cccggctgcg gagcgacgac accgccgtgt actactgcgc cagagcccgg    300

tccttctact acgccatgga ctgctggggc cagggcacct ctgtgaccgt gtcctcc       357


<210>  60
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  hz214B2 Heavy Chain Variable domain Var 3

<400>  60
caggtgcagc tggtgcagtc cggcgctgaa gtgaagaaac ccggcgcttc cgtgaagctg     60

tcctgcaagg cctccggcta caccttcacc tccagctcca tgcactgggt gcgacaggcc    120

cctggacagg gcctggaatg gatgggcgag attcacccca actccggcaa caccaacaac    180

gcccagaaat tccagggcag agccaccctg accgtggaca cctccatctc caccgcctac    240

gtggaactgt cccggctgcg gagcgacgac accgccgtgt actactgcgc cagagcccgg    300

tccttctact acgccatgga ctgctggggc cagggcacct ctgtgaccgt gtcctcc       357


<210>  61
<211>  357
<212>  DNA
<213>  Artificial

<220>
<223>  hz214B2 Heavy Chain Variable domain Var 4

<400>  61
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcgccag cgtgaagctg     60

agctgcaagg ccagcggcta caccttcacc agctcctcca tgcactgggt gcggcaggca    120

ccaggtcagg gcctggagtg gatgggcgag atccacccca actccggaaa caccaacaac    180

aacgagaagt tcaagggccg ggccaccctg accgtggaca ccagcatcag caccgcctac    240

gtggagctga gccggctgcg gagcgacgac accgccgtgt actactgcgc cagagcccgg    300

agcttctact acgcaatgga ctgctggggc cagggcacca gcgtgaccgt gagcagc       357


<210>  62
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  hz214B2 Light Chain Full length Var1

<400>  62

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          

Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Gly Ala Ser Ser Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Thr Tyr Ser Phe Pro Tyr 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             

Phe Asn Arg Gly Glu Cys 
    210                 


<210>  63
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  hz214B2 Light Chain Full length Var 2

<400>  63

Asn Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          

Val Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Gly Ala Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Thr Tyr Tyr Cys Gly Gln Thr Tyr Ser Phe Pro Tyr 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             

Phe Asn Arg Gly Glu Cys 
    210                 


<210>  64
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  hz214B2 Light Chain Full length Var 3

<400>  64

Asn Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          

Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Gly Ala Ser Asn Leu Tyr Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Thr Tyr His Cys Gly Gln Thr Tyr Ser Phe Pro Tyr 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             

Phe Asn Arg Gly Glu Cys 
    210                 


<210>  65
<211>  214
<212>  PRT
<213>  Artificial

<220>
<223>  hz214B2 Light Chain Full length Var 4

<400>  65

Asn Ile Val Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      

Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Glu Asn Val Gly Thr Tyr 
            20                  25                  30          

Val Ser Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              

Tyr Gly Ala Ser Asn Arg Tyr Thr Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  

Ser Gly Ser Ala Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  

Glu Asp Phe Ala Thr Tyr His Cys Gly Gln Thr Tyr Ser Phe Pro Tyr 
                85                  90                  95      

Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         

Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             

Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 

Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 

Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     

Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         

Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             

Phe Asn Arg Gly Glu Cys 
    210                 


<210>  66
<211>  449
<212>  PRT
<213>  Artificial

<220>
<223>  hz214B2 Heavy Chain Full length IgG1 Var1

<400>  66

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          

Ser Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              

Gly Trp Ile His Pro Asn Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  

Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  

Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Ala Arg Ser Phe Tyr Tyr Ala Met Asp Cys Trp Gly Gln Gly 
            100                 105                 110         

Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             

Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 

Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 

Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     

Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         

Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             

Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 

Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 

Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     

Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         

Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             

Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 

Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 

Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     

Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         

Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             

Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 

Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 

Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     

Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         

Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             

Lys 
    


<210>  67
<211>  449
<212>  PRT
<213>  Artificial

<220>
<223>  hz214B2 Heavy Chain Full length IgG1 Var 2

<400>  67

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          

Ser Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              

Gly Glu Ile His Pro Asn Ser Gly Asn Thr Asn Asn Ala Gln Lys Phe 
    50                  55                  60                  

Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  

Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Ala Arg Ser Phe Tyr Tyr Ala Met Asp Cys Trp Gly Gln Gly 
            100                 105                 110         

Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             

Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 

Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 

Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     

Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         

Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             

Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 

Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 

Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     

Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         

Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             

Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 

Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 

Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     

Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         

Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             

Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 

Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 

Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     

Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         

Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             

Lys 
    


<210>  68
<211>  449
<212>  PRT
<213>  Artificial

<220>
<223>  hz214B2 Heavy Chain Full length IgG1 Var 3

<400>  68

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          

Ser Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              

Gly Glu Ile His Pro Asn Ser Gly Asn Thr Asn Asn Ala Gln Lys Phe 
    50                  55                  60                  

Gln Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  

Val Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Ala Arg Ser Phe Tyr Tyr Ala Met Asp Cys Trp Gly Gln Gly 
            100                 105                 110         

Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             

Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 

Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 

Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     

Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         

Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             

Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 

Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 

Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     

Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         

Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             

Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 

Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 

Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     

Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         

Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             

Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 

Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 

Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     

Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         

Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             

Lys 
    


<210>  69
<211>  449
<212>  PRT
<213>  Artificial

<220>
<223>  hz214B2 Heavy Chain Full length IgG1 Var 4

<400>  69

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          

Ser Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              

Gly Glu Ile His Pro Asn Ser Gly Asn Thr Asn Asn Asn Glu Lys Phe 
    50                  55                  60                  

Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  

Val Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Ala Arg Ser Phe Tyr Tyr Ala Met Asp Cys Trp Gly Gln Gly 
            100                 105                 110         

Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             

Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr Ala Ala Leu 
    130                 135                 140                 

Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 

Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     

Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         

Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn His Lys Pro 
        195                 200                 205             

Ser Asn Thr Lys Val Asp Lys Arg Val Glu Pro Lys Ser Cys Asp Lys 
    210                 215                 220                 

Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 

Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     

Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         

Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             

Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 

Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 

Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     

Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         

Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             

Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 

Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 

Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     

Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         

Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             

Lys 
    


<210>  70
<211>  444
<212>  PRT
<213>  Artificial

<220>
<223>  hz214B2 Heavy Chain Full length IgG2 Var1

<400>  70

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          

Ser Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              

Gly Trp Ile His Pro Asn Ser Gly Asn Thr Asn Tyr Ala Gln Lys Phe 
    50                  55                  60                  

Gln Gly Arg Val Thr Met Thr Arg Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  

Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Ala Arg Ser Phe Tyr Tyr Ala Met Asp Cys Trp Gly Gln Gly 
            100                 105                 110         

Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             

Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 

Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 

Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     

Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         

Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             

Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 
    210                 215                 220                 

Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     

Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
            260                 265                 270         

Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             

Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
    290                 295                 300                 

Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 

Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     

Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         

Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             

Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 

Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
385                 390                 395                 400 

Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     

Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         

His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 


<210>  71
<211>  444
<212>  PRT
<213>  Artificial

<220>
<223>  hz214B2 Heavy Chain Full length IgG2 Var 2

<400>  71

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          

Ser Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              

Gly Glu Ile His Pro Asn Ser Gly Asn Thr Asn Asn Ala Gln Lys Phe 
    50                  55                  60                  

Gln Gly Arg Val Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  

Met Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Ala Arg Ser Phe Tyr Tyr Ala Met Asp Cys Trp Gly Gln Gly 
            100                 105                 110         

Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             

Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 

Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 

Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     

Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         

Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             

Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 
    210                 215                 220                 

Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     

Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
            260                 265                 270         

Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             

Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
    290                 295                 300                 

Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 

Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     

Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         

Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             

Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 

Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
385                 390                 395                 400 

Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     

Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         

His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 


<210>  72
<211>  444
<212>  PRT
<213>  Artificial

<220>
<223>  hz214B2 Heavy Chain Full length IgG2 Var 3

<400>  72

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          

Ser Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              

Gly Glu Ile His Pro Asn Ser Gly Asn Thr Asn Asn Ala Gln Lys Phe 
    50                  55                  60                  

Gln Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  

Val Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Ala Arg Ser Phe Tyr Tyr Ala Met Asp Cys Trp Gly Gln Gly 
            100                 105                 110         

Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             

Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 

Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 

Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     

Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         

Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             

Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 
    210                 215                 220                 

Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     

Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
            260                 265                 270         

Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             

Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
    290                 295                 300                 

Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 

Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     

Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         

Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             

Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 

Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
385                 390                 395                 400 

Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     

Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         

His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 


<210>  73
<211>  444
<212>  PRT
<213>  Artificial

<220>
<223>  hz214B2 Heavy Chain Full length IgG2 Var 4

<400>  73

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      

Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          

Ser Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Met 
        35                  40                  45              

Gly Glu Ile His Pro Asn Ser Gly Asn Thr Asn Asn Asn Glu Lys Phe 
    50                  55                  60                  

Lys Gly Arg Ala Thr Leu Thr Val Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  

Val Glu Leu Ser Arg Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      

Ala Arg Ala Arg Ser Phe Tyr Tyr Ala Met Asp Cys Trp Gly Gln Gly 
            100                 105                 110         

Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe 
        115                 120                 125             

Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu 
    130                 135                 140                 

Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp 
145                 150                 155                 160 

Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu 
                165                 170                 175     

Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser 
            180                 185                 190         

Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro 
        195                 200                 205             

Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu 
    210                 215                 220                 

Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 

Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     

Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln 
            260                 265                 270         

Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             

Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu 
    290                 295                 300                 

Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 

Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     

Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         

Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             

Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 

Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly 
385                 390                 395                 400 

Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     

Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         

His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 


<210>  74
<211>  642
<212>  DNA
<213>  Artificial

<220>
<223>  hz214B2 Light Chain Full length Var1

<400>  74
gacatccaga tgacccagtc cccctccagc ctgtccgcct ctgtgggcga cagagtgacc     60

atcacctgtc gggcctccga gaacgtgggc acctacctga actggtacca gcagaagccc    120

ggcaaggccc ccaagctgct gatctacggc gccagctccc tgcagtccgg cgtgccctcc    180

agattctccg gctctggctc cggcaccgac tttaccctga ccatctccag cctgcagccc    240

gaggacttcg ccacctacta ctgcggccag acctactcct tcccctacac cttcggccag    300

ggcaccaagc tggaaatcaa gcgtacggtg gccgctccca gcgtgttcat cttcccccca    360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac    420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag    480

gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc    540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc    600

ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gc                       642


<210>  75
<211>  642
<212>  DNA
<213>  Artificial

<220>
<223>  hz214B2 Light Chain Full length Var 2

<400>  75
aacatccaga tgacccagtc cccctccagc ctgtccgcct ctgtgggcga cagagtgacc     60

atcacctgtc gggcctccga gaacgtgggc acctacgtga actggtacca gcagaagccc    120

ggcaaggccc ccaagctgct gatctacggc gcctccaacc tgcagtccgg cgtgccctcc    180

cggttctctg gctctggctc cgccaccgac tttaccctga ccatctccag cctgcagccc    240

gaggacttcg ccacctacta ctgcggccag acctactcct tcccctacac cttcggccag    300

ggcaccaagc tggaaatcaa gcgtacggtg gccgctccca gcgtgttcat cttcccccca    360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac    420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag    480

gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc    540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc    600

ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gc                       642


<210>  76
<211>  642
<212>  DNA
<213>  Artificial

<220>
<223>  hz214B2 Light Chain Full length Var 3

<400>  76
aacatcgtga tgacccagtc cccctccagc ctgtccgcct ctgtgggcga cagagtgacc     60

atcacatgca aggcctccga gaacgtgggc acctacgtgt cctggtacca gcagaagccc    120

ggcaaggccc ccaagctgct gatctacggc gcctccaacc tgtactccgg cgtgccctcc    180

cggttctccg gctctggctc tgccaccgac tttaccctga ccatctccag cctgcagccc    240

gaggacttcg ccacctacca ctgcggccag acctactcct tcccctacac cttcggccag    300

ggcaccaagc tggaaatcaa gcgtacggtg gccgctccca gcgtgttcat cttcccccca    360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac    420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag    480

gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc    540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc    600

ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gc                       642


<210>  77
<211>  642
<212>  DNA
<213>  Artificial

<220>
<223>  hz214B2 Light Chain Full length Var 4

<400>  77
aacatcgtga tgacccagag ccccagcagc ctgagcgcca gcgtgggcga ccgggtgacc     60

atcacctgca aggctagcga gaacgtcggc acctacgtgt cctggtacca gcagaagccc    120

ggcaaggccc ccaagctgct gatctacggc gccagcaacc gctacaccgg cgtgcccagc    180

cggttcagcg gcagcggcag cgccaccgac ttcaccctga ccatcagcag cctgcagccc    240

gaggacttcg ccacctacca ctgcgggcag acctacagct tcccctacac cttcggccag    300

ggcaccaagc tggagatcaa gcgtacggtg gccgctccca gcgtgttcat cttcccccca    360

agcgacgagc agctgaagag cggcaccgcc agcgtggtgt gtctgctgaa caacttctac    420

cccagggagg ccaaggtgca gtggaaggtg gacaacgccc tgcagagcgg caacagccag    480

gagagcgtca ccgagcagga cagcaaggac tccacctaca gcctgagcag caccctgacc    540

ctgagcaagg ccgactacga gaagcacaag gtgtacgcct gtgaggtgac ccaccagggc    600

ctgtccagcc ccgtgaccaa gagcttcaac aggggcgagt gc                       642


<210>  78
<211>  1347
<212>  DNA
<213>  Artificial

<220>
<223>  hz214B2 Heavy Chain Full length IgG1 Var1

<400>  78
caggtgcagc tggtgcagtc cggcgctgaa gtgaagaaac ccggcgcttc cgtgaaggtg     60

tcctgcaagg cctccggcta caccttcacc tccagctcca tgcactgggt gcgacaggcc    120

cctggacagg gcctggaatg gatgggctgg attcacccca actccggcaa caccaactac    180

gcccagaaat tccagggcag agtgaccatg acccgggaca cctccatctc caccgcctac    240

atggaactgt cccggctgcg gagcgacgac accgccgtgt actactgcgc cagagcccgg    300

tccttctact acgccatgga ctgctggggc cagggcacct ctgtgaccgt gtcctccgcc    360

tccaccaagg gcccttccgt gttcccgcta gcccccagca gcaagagcac cagcggcggc    420

acagccgccc tgggctgcct ggtgaaggac tacttccccg agcccgtgac cgtgtcctgg    480

aacagcggag ccctgacctc cggcgtgcac accttccccg ccgtgctgca gagcagcggc    540

ctgtacagcc tgagcagcgt ggtgaccgtg cccagcagca gcctgggcac ccagacctac    600

atctgtaacg tgaaccacaa gcccagcaac accaaggtgg acaagagagt ggagcccaag    660

agctgtgaca agacccacac ctgccccccc tgcccagccc ccgagctgct gggcggaccc    720

agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagcag aacccccgag    780

gtgacctgtg tggtggtgga cgtgtcccac gaggacccag aggtgaagtt caactggtac    840

gtggacggcg tggaggtgca caacgccaag accaagccca gagaggagca gtacaacagc    900

acctacaggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggag    960

tacaagtgta aggtgtccaa caaggccctg ccagccccaa tcgaaaagac catcagcaag   1020

gccaagggcc agccaagaga gccccaggtg tacaccctgc cacccagcag ggaggagatg   1080

accaagaacc aggtgtccct gacctgtctg gtgaagggct tctacccaag cgacatcgcc   1140

gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc cccagtgctg   1200

gacagcgacg gcagcttctt cctgtacagc aagctgaccg tggacaagag cagatggcag   1260

cagggcaacg tgttcagctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag   1320

aagagcctga gcctgtcccc aggcaag                                       1347


<210>  79
<211>  1347
<212>  DNA
<213>  Artificial

<220>
<223>  hz214B2 Heavy Chain Full length IgG1 Var 2

<400>  79
caggtgcagc tggtgcagtc cggcgctgaa gtgaagaaac ccggcgcttc cgtgaaggtg     60

tcctgcaagg cctccggcta caccttcacc tccagctcca tgcactgggt gcgacaggcc    120

cctggacagg gcctggaatg gatgggcgag attcacccca actccggcaa caccaacaac    180

gcccagaaat tccagggcag agtgaccctg accgtggaca cctccatctc caccgcctac    240

atggaactgt cccggctgcg gagcgacgac accgccgtgt actactgcgc cagagcccgg    300

tccttctact acgccatgga ctgctggggc cagggcacct ctgtgaccgt gtcctccgcc    360

tccaccaagg gcccttccgt gttcccgcta gcccccagca gcaagagcac cagcggcggc    420

acagccgccc tgggctgcct ggtgaaggac tacttccccg agcccgtgac cgtgtcctgg    480

aacagcggag ccctgacctc cggcgtgcac accttccccg ccgtgctgca gagcagcggc    540

ctgtacagcc tgagcagcgt ggtgaccgtg cccagcagca gcctgggcac ccagacctac    600

atctgtaacg tgaaccacaa gcccagcaac accaaggtgg acaagagagt ggagcccaag    660

agctgtgaca agacccacac ctgccccccc tgcccagccc ccgagctgct gggcggaccc    720

agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagcag aacccccgag    780

gtgacctgtg tggtggtgga cgtgtcccac gaggacccag aggtgaagtt caactggtac    840

gtggacggcg tggaggtgca caacgccaag accaagccca gagaggagca gtacaacagc    900

acctacaggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggag    960

tacaagtgta aggtgtccaa caaggccctg ccagccccaa tcgaaaagac catcagcaag   1020

gccaagggcc agccaagaga gccccaggtg tacaccctgc cacccagcag ggaggagatg   1080

accaagaacc aggtgtccct gacctgtctg gtgaagggct tctacccaag cgacatcgcc   1140

gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc cccagtgctg   1200

gacagcgacg gcagcttctt cctgtacagc aagctgaccg tggacaagag cagatggcag   1260

cagggcaacg tgttcagctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag   1320

aagagcctga gcctgtcccc aggcaag                                       1347


<210>  80
<211>  1347
<212>  DNA
<213>  Artificial

<220>
<223>  hz214B2 Heavy Chain Full length IgG1 Var 3

<400>  80
caggtgcagc tggtgcagtc cggcgctgaa gtgaagaaac ccggcgcttc cgtgaagctg     60

tcctgcaagg cctccggcta caccttcacc tccagctcca tgcactgggt gcgacaggcc    120

cctggacagg gcctggaatg gatgggcgag attcacccca actccggcaa caccaacaac    180

gcccagaaat tccagggcag agccaccctg accgtggaca cctccatctc caccgcctac    240

gtggaactgt cccggctgcg gagcgacgac accgccgtgt actactgcgc cagagcccgg    300

tccttctact acgccatgga ctgctggggc cagggcacct ctgtgaccgt gtcctccgcc    360

tccaccaagg gcccttccgt gttcccgcta gcccccagca gcaagagcac cagcggcggc    420

acagccgccc tgggctgcct ggtgaaggac tacttccccg agcccgtgac cgtgtcctgg    480

aacagcggag ccctgacctc cggcgtgcac accttccccg ccgtgctgca gagcagcggc    540

ctgtacagcc tgagcagcgt ggtgaccgtg cccagcagca gcctgggcac ccagacctac    600

atctgtaacg tgaaccacaa gcccagcaac accaaggtgg acaagagagt ggagcccaag    660

agctgtgaca agacccacac ctgccccccc tgcccagccc ccgagctgct gggcggaccc    720

agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagcag aacccccgag    780

gtgacctgtg tggtggtgga cgtgtcccac gaggacccag aggtgaagtt caactggtac    840

gtggacggcg tggaggtgca caacgccaag accaagccca gagaggagca gtacaacagc    900

acctacaggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggag    960

tacaagtgta aggtgtccaa caaggccctg ccagccccaa tcgaaaagac catcagcaag   1020

gccaagggcc agccaagaga gccccaggtg tacaccctgc cacccagcag ggaggagatg   1080

accaagaacc aggtgtccct gacctgtctg gtgaagggct tctacccaag cgacatcgcc   1140

gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc cccagtgctg   1200

gacagcgacg gcagcttctt cctgtacagc aagctgaccg tggacaagag cagatggcag   1260

cagggcaacg tgttcagctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag   1320

aagagcctga gcctgtcccc aggcaag                                       1347


<210>  81
<211>  1347
<212>  DNA
<213>  Artificial

<220>
<223>  hz214B2 Heavy Chain Full length IgG1 Var 4

<400>  81
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcgccag cgtgaagctg     60

agctgcaagg ccagcggcta caccttcacc agctcctcca tgcactgggt gcggcaggca    120

ccaggtcagg gcctggagtg gatgggcgag atccacccca actccggaaa caccaacaac    180

aacgagaagt tcaagggccg ggccaccctg accgtggaca ccagcatcag caccgcctac    240

gtggagctga gccggctgcg gagcgacgac accgccgtgt actactgcgc cagagcccgg    300

agcttctact acgcaatgga ctgctggggc cagggcacca gcgtgaccgt gagcagcgcc    360

tccaccaagg gcccttccgt gttcccgcta gcccccagca gcaagagcac cagcggcggc    420

acagccgccc tgggctgcct ggtgaaggac tacttccccg agcccgtgac cgtgtcctgg    480

aacagcggag ccctgacctc cggcgtgcac accttccccg ccgtgctgca gagcagcggc    540

ctgtacagcc tgagcagcgt ggtgaccgtg cccagcagca gcctgggcac ccagacctac    600

atctgtaacg tgaaccacaa gcccagcaac accaaggtgg acaagagagt ggagcccaag    660

agctgtgaca agacccacac ctgccccccc tgcccagccc ccgagctgct gggcggaccc    720

agcgtgttcc tgttcccccc caagcccaag gacaccctga tgatcagcag aacccccgag    780

gtgacctgtg tggtggtgga cgtgtcccac gaggacccag aggtgaagtt caactggtac    840

gtggacggcg tggaggtgca caacgccaag accaagccca gagaggagca gtacaacagc    900

acctacaggg tggtgtccgt gctgaccgtg ctgcaccagg actggctgaa cggcaaggag    960

tacaagtgta aggtgtccaa caaggccctg ccagccccaa tcgaaaagac catcagcaag   1020

gccaagggcc agccaagaga gccccaggtg tacaccctgc cacccagcag ggaggagatg   1080

accaagaacc aggtgtccct gacctgtctg gtgaagggct tctacccaag cgacatcgcc   1140

gtggagtggg agagcaacgg ccagcccgag aacaactaca agaccacccc cccagtgctg   1200

gacagcgacg gcagcttctt cctgtacagc aagctgaccg tggacaagag cagatggcag   1260

cagggcaacg tgttcagctg ctccgtgatg cacgaggccc tgcacaacca ctacacccag   1320

aagagcctga gcctgtcccc aggcaag                                       1347


<210>  82
<211>  1332
<212>  DNA
<213>  Artificial

<220>
<223>  hz214B2 Heavy Chain Full length IgG2 Var 1

<400>  82
caggtgcagc tggtgcagtc cggcgctgaa gtgaagaaac ccggcgcttc cgtgaaggtg     60

tcctgcaagg cctccggcta caccttcacc tccagctcca tgcactgggt gcgacaggcc    120

cctggacagg gcctggaatg gatgggctgg attcacccca actccggcaa caccaactac    180

gcccagaaat tccagggcag agtgaccatg acccgggaca cctccatctc caccgcctac    240

atggaactgt cccggctgcg gagcgacgac accgccgtgt actactgcgc cagagcccgg    300

tccttctact acgccatgga ctgctggggc cagggcacct ctgtgaccgt gtcctccgcc    360

tccaccaagg gcccttccgt gttcccgcta gcgccctgct ccagaagcac cagcgagagc    420

acagccgccc tgggctgcct ggtgaaggac tacttccccg agcccgtgac cgtgtcctgg    480

aacagcggag ccctgaccag cggcgtgcac accttccccg ccgtgctgca gagcagcggc    540

ctgtacagcc tgagcagcgt ggtgaccgtg ccaagcagca acttcggcac ccagacctac    600

acctgtaacg tggaccacaa gcccagcaac accaaggtgg acaagaccgt ggagaggaag    660

tgctgtgtgg agtgcccccc ctgcccagcc cccccagtgg ccggacccag cgtgttcctg    720

ttccccccca agcccaagga caccctgatg atcagcagaa cccccgaggt gacctgtgtg    780

gtggtggacg tgtcccacga ggaccccgag gtgcagttca actggtacgt ggacggcgtg    840

gaggtgcaca acgccaagac caagcccaga gaggagcagt ttaacagcac cttccgggtg    900

gtgtccgtgc tgaccgtggt gcaccaggac tggctgaacg gcaaggagta caagtgtaag    960

gtctccaaca agggcctgcc agcccccatc gaaaagacca tcagcaagac caagggacag   1020

ccaagagagc cacaggtcta caccctgccc cccagcaggg aggagatgac caagaaccag   1080

gtgtccctga cctgtctggt gaagggcttc tacccaagcg acatcgccgt ggagtgggag   1140

agcaacggcc agcccgagaa caactacaag accacccccc caatgctgga cagcgacggc   1200

agcttcttcc tgtacagcaa gctgacagtg gacaagagca gatggcagca gggcaacgtg   1260

ttcagctgct ccgtgatgca cgaggccctg cacaaccact acacccagaa gagcctgagc   1320

ctgtccccag gc                                                       1332


<210>  83
<211>  1332
<212>  DNA
<213>  Artificial

<220>
<223>  hz214B2 Heavy Chain Full length IgG2 Var 2

<400>  83
caggtgcagc tggtgcagtc cggcgctgaa gtgaagaaac ccggcgcttc cgtgaaggtg     60

tcctgcaagg cctccggcta caccttcacc tccagctcca tgcactgggt gcgacaggcc    120

cctggacagg gcctggaatg gatgggcgag attcacccca actccggcaa caccaacaac    180

gcccagaaat tccagggcag agtgaccctg accgtggaca cctccatctc caccgcctac    240

atggaactgt cccggctgcg gagcgacgac accgccgtgt actactgcgc cagagcccgg    300

tccttctact acgccatgga ctgctggggc cagggcacct ctgtgaccgt gtcctccgcc    360

tccaccaagg gcccttccgt gttcccgcta gcgccctgct ccagaagcac cagcgagagc    420

acagccgccc tgggctgcct ggtgaaggac tacttccccg agcccgtgac cgtgtcctgg    480

aacagcggag ccctgaccag cggcgtgcac accttccccg ccgtgctgca gagcagcggc    540

ctgtacagcc tgagcagcgt ggtgaccgtg ccaagcagca acttcggcac ccagacctac    600

acctgtaacg tggaccacaa gcccagcaac accaaggtgg acaagaccgt ggagaggaag    660

tgctgtgtgg agtgcccccc ctgcccagcc cccccagtgg ccggacccag cgtgttcctg    720

ttccccccca agcccaagga caccctgatg atcagcagaa cccccgaggt gacctgtgtg    780

gtggtggacg tgtcccacga ggaccccgag gtgcagttca actggtacgt ggacggcgtg    840

gaggtgcaca acgccaagac caagcccaga gaggagcagt ttaacagcac cttccgggtg    900

gtgtccgtgc tgaccgtggt gcaccaggac tggctgaacg gcaaggagta caagtgtaag    960

gtctccaaca agggcctgcc agcccccatc gaaaagacca tcagcaagac caagggacag   1020

ccaagagagc cacaggtcta caccctgccc cccagcaggg aggagatgac caagaaccag   1080

gtgtccctga cctgtctggt gaagggcttc tacccaagcg acatcgccgt ggagtgggag   1140

agcaacggcc agcccgagaa caactacaag accacccccc caatgctgga cagcgacggc   1200

agcttcttcc tgtacagcaa gctgacagtg gacaagagca gatggcagca gggcaacgtg   1260

ttcagctgct ccgtgatgca cgaggccctg cacaaccact acacccagaa gagcctgagc   1320

ctgtccccag gc                                                       1332


<210>  84
<211>  1332
<212>  DNA
<213>  Artificial

<220>
<223>  hz214B2 Heavy Chain Full length IgG2 Var 3

<400>  84
caggtgcagc tggtgcagtc cggcgctgaa gtgaagaaac ccggcgcttc cgtgaagctg     60

tcctgcaagg cctccggcta caccttcacc tccagctcca tgcactgggt gcgacaggcc    120

cctggacagg gcctggaatg gatgggcgag attcacccca actccggcaa caccaacaac    180

gcccagaaat tccagggcag agccaccctg accgtggaca cctccatctc caccgcctac    240

gtggaactgt cccggctgcg gagcgacgac accgccgtgt actactgcgc cagagcccgg    300

tccttctact acgccatgga ctgctggggc cagggcacct ctgtgaccgt gtcctccgcc    360

tccaccaagg gcccttccgt gttcccgcta gcgccctgct ccagaagcac cagcgagagc    420

acagccgccc tgggctgcct ggtgaaggac tacttccccg agcccgtgac cgtgtcctgg    480

aacagcggag ccctgaccag cggcgtgcac accttccccg ccgtgctgca gagcagcggc    540

ctgtacagcc tgagcagcgt ggtgaccgtg ccaagcagca acttcggcac ccagacctac    600

acctgtaacg tggaccacaa gcccagcaac accaaggtgg acaagaccgt ggagaggaag    660

tgctgtgtgg agtgcccccc ctgcccagcc cccccagtgg ccggacccag cgtgttcctg    720

ttccccccca agcccaagga caccctgatg atcagcagaa cccccgaggt gacctgtgtg    780

gtggtggacg tgtcccacga ggaccccgag gtgcagttca actggtacgt ggacggcgtg    840

gaggtgcaca acgccaagac caagcccaga gaggagcagt ttaacagcac cttccgggtg    900

gtgtccgtgc tgaccgtggt gcaccaggac tggctgaacg gcaaggagta caagtgtaag    960

gtctccaaca agggcctgcc agcccccatc gaaaagacca tcagcaagac caagggacag   1020

ccaagagagc cacaggtcta caccctgccc cccagcaggg aggagatgac caagaaccag   1080

gtgtccctga cctgtctggt gaagggcttc tacccaagcg acatcgccgt ggagtgggag   1140

agcaacggcc agcccgagaa caactacaag accacccccc caatgctgga cagcgacggc   1200

agcttcttcc tgtacagcaa gctgacagtg gacaagagca gatggcagca gggcaacgtg   1260

ttcagctgct ccgtgatgca cgaggccctg cacaaccact acacccagaa gagcctgagc   1320

ctgtccccag gc                                                       1332


<210>  85
<211>  1332
<212>  DNA
<213>  Artificial

<220>
<223>  hz214B2 Heavy Chain Full length IgG2 Var 4

<400>  85
caggtgcagc tggtgcagag cggcgccgag gtgaagaagc ccggcgccag cgtgaagctg     60

agctgcaagg ccagcggcta caccttcacc agctcctcca tgcactgggt gcggcaggca    120

ccaggtcagg gcctggagtg gatgggcgag atccacccca actccggaaa caccaacaac    180

aacgagaagt tcaagggccg ggccaccctg accgtggaca ccagcatcag caccgcctac    240

gtggagctga gccggctgcg gagcgacgac accgccgtgt actactgcgc cagagcccgg    300

agcttctact acgcaatgga ctgctggggc cagggcacca gcgtgaccgt gagcagcgcc    360

tccaccaagg gcccttccgt gttcccgcta gcgccctgct ccagaagcac cagcgagagc    420

acagccgccc tgggctgcct ggtgaaggac tacttccccg agcccgtgac cgtgtcctgg    480

aacagcggag ccctgaccag cggcgtgcac accttccccg ccgtgctgca gagcagcggc    540

ctgtacagcc tgagcagcgt ggtgaccgtg ccaagcagca acttcggcac ccagacctac    600

acctgtaacg tggaccacaa gcccagcaac accaaggtgg acaagaccgt ggagaggaag    660

tgctgtgtgg agtgcccccc ctgcccagcc cccccagtgg ccggacccag cgtgttcctg    720

ttccccccca agcccaagga caccctgatg atcagcagaa cccccgaggt gacctgtgtg    780

gtggtggacg tgtcccacga ggaccccgag gtgcagttca actggtacgt ggacggcgtg    840

gaggtgcaca acgccaagac caagcccaga gaggagcagt ttaacagcac cttccgggtg    900

gtgtccgtgc tgaccgtggt gcaccaggac tggctgaacg gcaaggagta caagtgtaag    960

gtctccaaca agggcctgcc agcccccatc gaaaagacca tcagcaagac caagggacag   1020

ccaagagagc cacaggtcta caccctgccc cccagcaggg aggagatgac caagaaccag   1080

gtgtccctga cctgtctggt gaagggcttc tacccaagcg acatcgccgt ggagtgggag   1140

agcaacggcc agcccgagaa caactacaag accacccccc caatgctgga cagcgacggc   1200

agcttcttcc tgtacagcaa gctgacagtg gacaagagca gatggcagca gggcaacgtg   1260

ttcagctgct ccgtgatgca cgaggccctg cacaaccact acacccagaa gagcctgagc   1320

ctgtccccag gc                                                       1332


