                         SEQUENCE LISTING

<110>  Batelle Energy Alliance, LLC
       Thompson, David N
       Apel, William A
       Vicki, Thompson S
       Reed, David W
 
<120>  THERMOPHILIC AND THERMOACIDOPHILIC LIGNOCELLULOSE-DEGRADING GENES
        AND ENZYMES FROM ALICYCLOBACILLUS ACIDOCALDARIUS

<130>  2939-8558US

<160>  464   

<170>  PatentIn version 3.3

<210>  1
<211>  843
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  1
ttgccgcgcg cgcgggagga ttggcgaatc gccatgtctg acaaggcgcg ggcgcgggac     60

aacgtcaagg tcggggtggc cctgggctct ggcggcgcca aggggttcgc gcacatcggc    120

gtgttgcttg ccctcgccga gcacggcgtt cctgtgcacg ccatcgccgg ttcgagcatg    180

ggggcgctgg tggcgggcgt gtacgcgatg ggggtgccac cgcgcgtgat gcgcgccctc    240

gccgtcaacc tgaggcggcg gcattggctg gatttcaccg tccccaagat gggcttcatc    300

cagggggaaa aggtgcgcac cgtggtggcc accatgaccc gccaggggac cttcgccgat    360

acggccatcc cgctcgccat cgtggcgacc gatctcataa agcgccggtt ggtggtgttc    420

cgatccggcc tcattgctga cgccgtccgg gcgagcattt cgatccctgg cgtgtttgtc    480

cccgtcgtgc gcgatggcgc cgtgtacgtc gacggaggcg tgctcgagcg cgtccctgtg    540

caggcgtgct gggacctcgg cgtcgatctc gtcatcgccg tggacgtcgg cgtgacgccg    600

agaggcacgc cgcccacctc cgccatggac gtgatcatgc agagcctcga gctgatgcag    660

gacgaagcgc tgcgcgcgcg cgaccgaggc gcaagcctga cgctcgtgcc ggaggtttct    720

cacatcggga cggcgcagct tcagcgcgca gccgaggcca tcgatctcgg ctatcaggcg    780

gcggtggcgc agttggaccg gatctgggat gccattgacc gcgcgggcgc ctttgtgtca    840

taa                                                                  843


<210>  2
<211>  280
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  2

Met Pro Arg Ala Arg Glu Asp Trp Arg Ile Ala Met Ser Asp Lys Ala 
1               5                   10                  15      


Arg Ala Arg Asp Asn Val Lys Val Gly Val Ala Leu Gly Ser Gly Gly 
            20                  25                  30          


Ala Lys Gly Phe Ala His Ile Gly Val Leu Leu Ala Leu Ala Glu His 
        35                  40                  45              


Gly Val Pro Val His Ala Ile Ala Gly Ser Ser Met Gly Ala Leu Val 
    50                  55                  60                  


Ala Gly Val Tyr Ala Met Gly Val Pro Pro Arg Val Met Arg Ala Leu 
65                  70                  75                  80  


Ala Val Asn Leu Arg Arg Arg His Trp Leu Asp Phe Thr Val Pro Lys 
                85                  90                  95      


Met Gly Phe Ile Gln Gly Glu Lys Val Arg Thr Val Val Ala Thr Met 
            100                 105                 110         


Thr Arg Gln Gly Thr Phe Ala Asp Thr Ala Ile Pro Leu Ala Ile Val 
        115                 120                 125             


Ala Thr Asp Leu Ile Lys Arg Arg Leu Val Val Phe Arg Ser Gly Leu 
    130                 135                 140                 


Ile Ala Asp Ala Val Arg Ala Ser Ile Ser Ile Pro Gly Val Phe Val 
145                 150                 155                 160 


Pro Val Val Arg Asp Gly Ala Val Tyr Val Asp Gly Gly Val Leu Glu 
                165                 170                 175     


Arg Val Pro Val Gln Ala Cys Trp Asp Leu Gly Val Asp Leu Val Ile 
            180                 185                 190         


Ala Val Asp Val Gly Val Thr Pro Arg Gly Thr Pro Pro Thr Ser Ala 
        195                 200                 205             


Met Asp Val Ile Met Gln Ser Leu Glu Leu Met Gln Asp Glu Ala Leu 
    210                 215                 220                 


Arg Ala Arg Asp Arg Gly Ala Ser Leu Thr Leu Val Pro Glu Val Ser 
225                 230                 235                 240 


His Ile Gly Thr Ala Gln Leu Gln Arg Ala Ala Glu Ala Ile Asp Leu 
                245                 250                 255     


Gly Tyr Gln Ala Ala Val Ala Gln Leu Asp Arg Ile Trp Asp Ala Ile 
            260                 265                 270         


Asp Arg Ala Gly Ala Phe Val Ser 
        275                 280 


<210>  3
<211>  276
<212>  PRT
<213>  Thermosinus carboxydivorans

<400>  3

Met Arg Pro Lys Ile Gly Leu Ala Leu Gly Ser Gly Gly Leu Arg Gly 
1               5                   10                  15      


Leu Ala His Val Gly Val Leu Arg Val Leu Glu Arg Glu Gly Ile Pro 
            20                  25                  30          


Ile Asp Cys Ile Ala Gly Cys Ser Ile Gly Ala Leu Val Gly Ala Leu 
        35                  40                  45              


Tyr Cys Ala Gly Leu Asp Pro Asp Thr Ile Tyr Lys Leu Ala Lys His 
    50                  55                  60                  


Thr Lys Arg Arg His Trp Leu Asp Phe Ile Ile Pro Lys Met Gly Ile 
65                  70                  75                  80  


Ile Ala Gly Glu Arg Val Leu Ala Met Leu Lys Leu Leu Thr Gln Gln 
                85                  90                  95      


Lys Gln Phe Ala Asp Leu Arg Ile Pro Leu Ala Val Val Ala Thr Glu 
            100                 105                 110         


Leu Thr Thr Gly Gln Glu Ile Val Phe Gln Glu Gly Asp Val Ala Gln 
        115                 120                 125             


Ala Val Arg Ala Ser Ile Ser Val Pro Gly Ile Phe Val Pro His Arg 
    130                 135                 140                 


Leu Asn Asp Met Leu Leu Val Asp Gly Ala Val Ile Asn Pro Thr Pro 
145                 150                 155                 160 


Ile Asp Val Ala Arg Arg Met Gly Ala Asn Ile Val Ile Ala Val Asp 
                165                 170                 175     


Leu Ala His Ala Gly Thr Val Cys Lys Ile Thr Asn Thr Phe Asp Val 
            180                 185                 190         


Ile Ile Gln Ser Ile Asp Ile Met Glu Arg Glu Leu Phe Lys His Arg 
        195                 200                 205             


Gln His Tyr Cys Asp Val Leu Ile Arg Pro Asp Val Ala His Ile Thr 
    210                 215                 220                 


Pro Ser Ser Phe Glu Thr Phe Asp Glu Cys Val Ala Leu Gly Glu Gln 
225                 230                 235                 240 


Ala Gly Glu Ala Ala Leu Pro Lys Ile Lys Ala Leu Leu Ala Glu Gly 
                245                 250                 255     


Gly Gln Arg Cys Ile Thr Ala Thr Gly Glu Asn Pro Ser Arg Pro Ser 
            260                 265                 270         


Asp Ser Gly Gly 
        275     


<210>  4
<211>  290
<212>  PRT
<213>  Bacillus NRRL B-14911

<400>  4

Met Phe Asp Ala Glu Val Ser Lys Phe Leu Thr Ile Ala Arg His Glu 
1               5                   10                  15      


Ser Tyr Ile Lys Gly Gly Met Leu Met Arg Gln Pro Val Ile Gly Leu 
            20                  25                  30          


Ala Leu Gly Ser Gly Gly Ala Arg Gly Phe Ala His Leu Gly Val Ile 
        35                  40                  45              


Lys Val Leu Lys Glu Glu Gly Ile Asn Val Asp Val Ile Ala Gly Ser 
    50                  55                  60                  


Ser Met Gly Ala Leu Val Gly Cys Phe Tyr Gly Ala Gly Leu Asp Ile 
65                  70                  75                  80  


Asp Arg Leu Tyr Lys Leu Ala Gly Ala Phe Lys Arg Lys Tyr Tyr Leu 
                85                  90                  95      


Asp Phe Thr Val Pro Lys Met Gly Phe Leu Ala Gly Lys Lys Val Lys 
            100                 105                 110         


Glu Leu Ile Arg Leu Phe Thr His Gly Lys Asn Leu Glu Asp Leu Asp 
        115                 120                 125             


Ile Pro Val Arg Val Val Ala Thr Asp Leu Lys Ala Gly Glu Lys Val 
    130                 135                 140                 


Val Phe Ser Lys Gly Pro Ile Ala Asp Ala Val Arg Ala Ser Ile Ser 
145                 150                 155                 160 


Ile Pro Gly Ile Phe Thr Pro Glu Lys Leu Glu Asp Arg Leu Leu Val 
                165                 170                 175     


Asp Gly Gly Val Ile Asp Arg Val Pro Val Ser Val Val Glu Glu Met 
            180                 185                 190         


Gly Ala Asp Leu Ile Ile Ala Val Asp Val Ser Arg Val Lys Thr Ser 
        195                 200                 205             


Ser Asp Ile Thr Ser Ile Phe Asp Val Ile Met Gln Ser Leu Asp Ile 
    210                 215                 220                 


Met Gln Met Glu Leu Val Ser Asn Arg Glu Ile Ala Ser Asp Ile Met 
225                 230                 235                 240 


Ile Arg Pro His Val Glu Met Tyr Ser Ser Arg Ala Phe Thr Asn Ile 
                245                 250                 255     


Glu Asp Ile Ile Arg Ile Gly Glu Glu Glu Ala Arg Lys Gln Val Pro 
            260                 265                 270         


Arg Ile Lys Glu Ala Ile Gln Asn Trp Lys Gly Gln Glu Asp Asp Glu 
        275                 280                 285             


Glu Lys 
    290 


<210>  5
<211>  260
<212>  PRT
<213>  Bacillus subtilis 

<400>  5

Met Ala Lys Pro Lys Ile Gly Leu Ala Leu Gly Ser Gly Gly Ala Arg 
1               5                   10                  15      


Gly Leu Ala His Leu Gly Val Leu Ser Ser Leu His Lys His Gln Ile 
            20                  25                  30          


Glu Val Asp Met Ile Ala Gly Ser Ser Met Gly Ala Leu Val Gly Ser 
        35                  40                  45              


Phe Tyr Ala Ala Gly His Asp Val Ala Thr Met Lys Lys Val Ala Lys 
    50                  55                  60                  


Ala Phe Lys Arg Arg Leu Tyr Ala Asp Tyr Thr Val Pro Lys Leu Gly 
65                  70                  75                  80  


Phe Leu Lys Gly Asp Arg Val Arg Gln Leu Val His Ala Tyr Thr Phe 
                85                  90                  95      


Gly Lys Pro Ile Glu Glu Leu Gln Ile Pro Leu Gly Ile Val Ala Cys 
            100                 105                 110         


Asp Leu Gln Thr Gly Glu Lys Ile Val Phe Arg Lys Gly Ser Val Ser 
        115                 120                 125             


Asp Ala Val Arg Ala Ser Ile Ser Ile Pro Gly Ile Phe Ile Pro Gln 
    130                 135                 140                 


Arg Leu Asp Gly Arg Leu Leu Val Asp Gly Ala Val Val Asp Arg Ile 
145                 150                 155                 160 


Pro Val Ser Val Val Lys Asp Met Gly Ala Asp Ile Ile Ile Ala Ser 
                165                 170                 175     


Asp Val Ser Arg Val Arg Lys Thr Glu Thr Ala Val His Ile Phe Asp 
            180                 185                 190         


Val Ile Met Gln Ser Met Asp Ile Leu Gln Asn Glu Leu Val Arg His 
        195                 200                 205             


Gln Thr Ile Ala Ala Asp Ile Met Ile Arg Pro Ser Leu Glu Thr Tyr 
    210                 215                 220                 


Ser Ser Ser Ser Phe Ala Asn Ile Glu Glu Met Ile Ser Ala Gly Glu 
225                 230                 235                 240 


Glu Ala Thr Asn Arg Met Ile Ser Lys Ile Arg Lys Glu Ile Glu Asn 
                245                 250                 255     


Trp Glu Gly Ser 
            260 


<210>  6
<211>  275
<212>  PRT
<213>  Bacillus halodurans 

<400>  6

Met Gly Lys Val His Arg Pro Lys Ile Gly Leu Ala Leu Gly Ser Gly 
1               5                   10                  15      


Gly Ala Arg Gly Tyr Ala His Ile Gly Val Leu Lys Val Leu Glu Gln 
            20                  25                  30          


Glu Lys Ile Pro Ile Asp Tyr Leu Ala Gly Ser Ser Met Gly Ala Leu 
        35                  40                  45              


Val Ala Ser Leu Tyr Gly Ala Gly His Pro Thr Glu His Leu Ile Arg 
    50                  55                  60                  


Phe Ala Asn Leu Phe Lys Arg Lys Tyr Tyr Leu Asp Phe Thr Val Pro 
65                  70                  75                  80  


Lys Met Gly Phe Ile Ala Gly His Arg Val Glu Glu Leu Ile Arg Val 
                85                  90                  95      


Leu Ala Lys Lys Lys Arg Val Glu Glu Leu Asp Pro Pro Val Arg Ile 
            100                 105                 110         


Val Ala Ala Asp Leu Leu Lys Gly Glu Arg Val Ile Leu Gln Glu Gly 
        115                 120                 125             


Asp Val Ala Glu Ala Val Arg Ala Ser Ile Ala Ile Pro Gly Ile Phe 
    130                 135                 140                 


Val Pro Lys Asn Ile Asn Asp Arg Leu Leu Ile Asp Gly Gly Val Ile 
145                 150                 155                 160 


Asp Arg Val Pro Val Ser Val Val Lys Glu Met Gly Ala Asp Leu Thr 
                165                 170                 175     


Ile Ala Val Asp Leu Thr Ile Phe Arg Glu Glu Leu Glu Ile Arg Ser 
            180                 185                 190         


Val Tyr Asp Val Ile Leu Gln Thr Met Asp Met Met Ser Lys Glu Leu 
        195                 200                 205             


Val Arg Val Gln Glu Ile Asp Cys Thr Val Met Ile Arg Pro Met Asn 
    210                 215                 220                 


Asp Arg Tyr Arg Ser Leu Ser Ser Ser Ile Asp Phe Glu Ala Val Asn 
225                 230                 235                 240 


Asp Leu Ile Leu Leu Gly Glu Arg Ala Ala Ile Ala Lys Ile Pro Glu 
                245                 250                 255     


Ile Lys Asp Ala Ile Ala Thr Trp Lys Glu Thr His Tyr Glu Thr Asp 
            260                 265                 270         


Glu Lys Ala 
        275 


<210>  7
<211>  263
<212>  PRT
<213>  Bacillus coagulans

<400>  7

Met Ala Gly Arg Pro Lys Ile Gly Leu Ala Leu Gly Ser Gly Gly Ala 
1               5                   10                  15      


Arg Gly Phe Ala His Ile Gly Val Leu Lys Val Phe Glu Glu Glu Gly 
            20                  25                  30          


Ile Pro Val Asp Met Ile Ser Gly Ser Ser Ile Gly Ala Leu Val Ala 
        35                  40                  45              


Ala Leu Tyr Gly Ala Gly Arg Thr Val Arg Glu Met Glu Leu Leu Ser 
    50                  55                  60                  


Gly Ala Phe Lys Arg Lys Tyr Tyr Leu Asp Phe Lys Ile Gly Lys Met 
65                  70                  75                  80  


Gly Leu Ile Ser Gly Lys Arg Ile Glu Asp Leu Ile Arg Leu Leu Val 
                85                  90                  95      


His Gly Lys Lys Leu Glu Glu Leu Asn Pro Pro Val Ala Val Val Ala 
            100                 105                 110         


Ala Asn Leu Ser Asn Gly Glu Lys Thr Val Phe Lys Lys Gly Pro Val 
        115                 120                 125             


Gln Glu Ala Val Arg Ala Ser Ile Ser Ile Pro Gly Ile Phe Val Pro 
    130                 135                 140                 


Lys Lys Ile Gly Gly His Leu Phe Val Asp Gly Gly Val Val Asp Arg 
145                 150                 155                 160 


Val Pro Val Ser Val Val Lys Glu Met Gly Ala Glu Leu Leu Ile Gly 
                165                 170                 175     


Val Asp Val Ser Val Met Lys Lys Glu Ala Glu Ile Arg His Ile Tyr 
            180                 185                 190         


Asp Val Ile Met Gln Ser Ile Asp Ile Met Gln Met Glu Leu Ala Glu 
        195                 200                 205             


Ser Arg Lys Thr Glu Ala His Val Leu Ile Arg Pro Asp Val Ser Met 
    210                 215                 220                 


Tyr Ser Ser Met Ala Phe Thr Asn Ala Gly Gln Ile Ile Lys Ile Gly 
225                 230                 235                 240 


Glu Glu Ala Ala Lys Gln Ser Val Thr Glu Ile Gln Gln Leu Leu Glu 
                245                 250                 255     


Lys Trp Lys Glu Pro Asp Lys 
            260             


<210>  8
<211>  843
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 1

<400>  8
ttgccgcgcg cgcgggagga ttggcgaatc gccatgtctg acaaggcgcg ggcgcgggac     60

aacgtcaaga tcggggtggc cctgggctct ggcggcgcca aggggttcgc gcacatcggc    120

gtgttgcttg ccctcgccga gcacggcgtt cctgtgcacg ccatcgccgg ttcgagcatg    180

ggggcgctgg tggcgggcgt gtacgcgatg ggggtgccac cgcgcgtgat gcgcgccctc    240

gccgtcaacc tgaggcggcg gcattggctg gatttcaccg tccccaagat gggcttcatc    300

cagggggaaa aggtgcgcac cgtggtggcc accatgaccc gccaggggac cttcgccgat    360

acggccatcc cgctcgccat cgtggcgacc gatctcataa agcgccggtt ggtggtgttc    420

cgatccggcc tcattgctga cgccgtccgg gcgagcattt cgatccctgg cgtgtttgtc    480

cccgtcgtgc gcgatggcgc cgtgtacgtc gacggaggcg tgctcgagcg cgtccctgtg    540

caggcgtgct gggacctcgg cgtcgatctc gtcatcgccg tggacgtcgg cgtgacgccg    600

agaggcacgc cgcccacctc cgccatggac gtgatcatgc agagcctcga gctgatgcag    660

gacgaagcgc tgcgcgcgcg cgaccgaggc gcaagcctga cgctcgtgcc ggaggtttct    720

cacatcggga cggcgcagct tcagcgcgca gccgaggcca tcgatctcgg ctatcaggcg    780

gcggtggcgc agttggaccg gatctgggat gccattgacc gcgcgggcgc ctttgtgtca    840

taa                                                                  843


<210>  9
<211>  843
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 1

<400>  9
ttgccgcgcg cgcgggagga ttggcgaatc gccatgtctg acaaggcgcg ggcgcgggac     60

aacgtcaagg tcggggtggc cctgggctct ggcggcgcca gggggttcgc gcacatcggc    120

gtgttgcttg ccctcgccga gcacggcgtt cctgtgcacg ccatcgccgg ttcgagcatg    180

ggggcgctgg tggcgggcgt gtacgcgatg ggggtgccac cgcgcgtgat gcgcgccctc    240

gccgtcaacc tgaggcggcg gcattggctg gatttcaccg tccccaagat gggcttcatc    300

cagggggaaa aggtgcgcac cgtggtggcc accatgaccc gccaggggac cttcgccgat    360

acggccatcc cgctcgccat cgtggcgacc gatctcataa agcgccggtt ggtggtgttc    420

cgatccggcc tcattgctga cgccgtccgg gcgagcattt cgatccctgg cgtgtttgtc    480

cccgtcgtgc gcgatggcgc cgtgtacgtc gacggaggcg tgctcgagcg cgtccctgtg    540

caggcgtgct gggacctcgg cgtcgatctc gtcatcgccg tggacgtcgg cgtgacgccg    600

agaggcacgc cgcccacctc cgccatggac gtgatcatgc agagcctcga gctgatgcag    660

gacgaagcgc tgcgcgcgcg cgaccgaggc gcaagcctga cgctcgtgcc ggaggtttct    720

cacatcggga cggcgcagct tcagcgcgca gccgaggcca tcgatctcgg ctatcaggcg    780

gcggtggcgc agttggaccg gatctgggat gccattgacc gcgcgggcgc ctttgtgtca    840

taa                                                                  843


<210>  10
<211>  843
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 1

<400>  10
ttgccgcgcg cgcgggagga ttggcgaatc gccatgtctg acaaggcgcg ggcgcgggac     60

aacgtcaagg tcgggctggc cctgggctct ggcggcgcca aggggttcgc gcacatcggc    120

gtgttgcttg ccctcgccga gcacggcgtt cctgtgcacg ccatcgccgg ttcgagcatg    180

ggggcgctgg tggcgggcgt gtacgcgatg ggggtgccac cgcgcgtgat gcgcgccctc    240

gccgtcaacc tgaggcggcg gcattggctg gatttcaccg tccccaagat gggcttcatc    300

cagggggaaa aggtgcgcac cgtggtggcc accatgaccc gccaggggac cttcgccgat    360

acggccatcc cgctcgccat cgtggcgacc gatctcataa agcgccggtt ggtggtgttc    420

cgatccggcc tcattgctga cgccgtccgg gcgagcattt cgatccctgg cgtgtttgtc    480

cccgtcgtgc gcgatggcgc cgtgtacgtc gacggaggcg tgctcgagcg cgtccctgtg    540

caggcgtgct gggacctcgg cgtcgatctc gtcatcgccg tggacgtcgg cgtgacgccg    600

agaggcacgc cgcccacctc cgccatggac gtgatcatgc agagcctcga gctgatgcag    660

gacgaagcgc tgcgcgcgcg cgaccgaggc gcaagcctga cgctcgtgcc ggaggtttct    720

cacatcggga cggcgcagct tcagcgcgca gccgaggcca tcgatctcgg ctatcaggcg    780

gcggtggcgc agttggaccg gatctgggat gccattgacc gcgcgggcgc ctttgtgtca    840

taa                                                                  843


<210>  11
<211>  840
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 1

<400>  11
ttgccgcgcg cgcgggagga ttggcgaatc gccatgtctg acaaggcgcg ggcgcgggac     60

aacgtcaagg tcggggtggc cctgggctct ggcggcgcca aggggttcgc gcacctcggc    120

gtgttgcttg ccctcgccga gcacggcgtt cctgtgcacg ccatcgccgg ttcgagcatg    180

ggggcgctgg tggcgggcgt gtacgcgatg ggggtgccac cgcgcgtgat gcgcgccctc    240

gccgtcaacc tgaggcggcg gcattggctg gatttcaccg tccccaagat gggcttcatc    300

cagggggaaa aggtgcgcac cgtggtggcc accatgaccc gccaggggac cttcgccgat    360

acggccatcc cgctcgccat cgtggcgacc gatctcataa agcgccggtt ggtggtgttc    420

cgatccggcc tcattgctga cgccgtccgg gcgagcattt cgatccctgg cgtgtttgtc    480

cccgtcgtgc gcgatggcgc cgtgtacgtc gacggaggcg tgctcgagcg cgtccctgtg    540

caggcgtgct gggacctcgg cgtcgatctc gtcatcgccg tggacgtcgg cgtgacgccg    600

agaggcacgc cgcccacctc cgccatggac gtgatcatgc agagcctcga gctgatgcag    660

gacgaagcgc tgcgcgcgcg cgaccgaggc gcaagcctga cgctcgtgcc ggaggtttct    720

cacatcggga cggcgcagct tcagcgcgca gccgaggcca tcgatctcgg ctatcaggcg    780

gcggtggcgc agttggaccg gatctgggat gccattgacc gcgcgggcgc ctttgtgtca    840


<210>  12
<211>  843
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 1

<400>  12
ttgccgcgcg cgcgggagga ttggcgaatc gccatgtctg acaaggcgcg ggcgcgggac     60

aacgtcaagg tcggggtggc cctgggctct ggcggcgcca aggggttcgc gcacgtcggc    120

gtgttgcttg ccctcgccga gcacggcgtt cctgtgcacg ccatcgccgg ttcgagcatg    180

ggggcgctgg tggcgggcgt gtacgcgatg ggggtgccac cgcgcgtgat gcgcgccctc    240

gccgtcaacc tgaggcggcg gcattggctg gatttcaccg tccccaagat gggcttcatc    300

cagggggaaa aggtgcgcac cgtggtggcc accatgaccc gccaggggac cttcgccgat    360

acggccatcc cgctcgccat cgtggcgacc gatctcataa agcgccggtt ggtggtgttc    420

cgatccggcc tcattgctga cgccgtccgg gcgagcattt cgatccctgg cgtgtttgtc    480

cccgtcgtgc gcgatggcgc cgtgtacgtc gacggaggcg tgctcgagcg cgtccctgtg    540

caggcgtgct gggacctcgg cgtcgatctc gtcatcgccg tggacgtcgg cgtgacgccg    600

agaggcacgc cgcccacctc cgccatggac gtgatcatgc agagcctcga gctgatgcag    660

gacgaagcgc tgcgcgcgcg cgaccgaggc gcaagcctga cgctcgtgcc ggaggtttct    720

cacatcggga cggcgcagct tcagcgcgca gccgaggcca tcgatctcgg ctatcaggcg    780

gcggtggcgc agttggaccg gatctgggat gccattgacc gcgcgggcgc ctttgtgtca    840

taa                                                                  843


<210>  13
<211>  280
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:2 and encoded by SEQ ID NO:13

<400>  13

Met Pro Arg Ala Arg Glu Asp Trp Arg Ile Ala Met Ser Asp Lys Ala 
1               5                   10                  15      


Arg Ala Arg Asp Asn Val Lys Ile Gly Val Ala Leu Gly Ser Gly Gly 
            20                  25                  30          


Ala Lys Gly Phe Ala His Ile Gly Val Leu Leu Ala Leu Ala Glu His 
        35                  40                  45              


Gly Val Pro Val His Ala Ile Ala Gly Ser Ser Met Gly Ala Leu Val 
    50                  55                  60                  


Ala Gly Val Tyr Ala Met Gly Val Pro Pro Arg Val Met Arg Ala Leu 
65                  70                  75                  80  


Ala Val Asn Leu Arg Arg Arg His Trp Leu Asp Phe Thr Val Pro Lys 
                85                  90                  95      


Met Gly Phe Ile Gln Gly Glu Lys Val Arg Thr Val Val Ala Thr Met 
            100                 105                 110         


Thr Arg Gln Gly Thr Phe Ala Asp Thr Ala Ile Pro Leu Ala Ile Val 
        115                 120                 125             


Ala Thr Asp Leu Ile Lys Arg Arg Leu Val Val Phe Arg Ser Gly Leu 
    130                 135                 140                 


Ile Ala Asp Ala Val Arg Ala Ser Ile Ser Ile Pro Gly Val Phe Val 
145                 150                 155                 160 


Pro Val Val Arg Asp Gly Ala Val Tyr Val Asp Gly Gly Val Leu Glu 
                165                 170                 175     


Arg Val Pro Val Gln Ala Cys Trp Asp Leu Gly Val Asp Leu Val Ile 
            180                 185                 190         


Ala Val Asp Val Gly Val Thr Pro Arg Gly Thr Pro Pro Thr Ser Ala 
        195                 200                 205             


Met Asp Val Ile Met Gln Ser Leu Glu Leu Met Gln Asp Glu Ala Leu 
    210                 215                 220                 


Arg Ala Arg Asp Arg Gly Ala Ser Leu Thr Leu Val Pro Glu Val Ser 
225                 230                 235                 240 


His Ile Gly Thr Ala Gln Leu Gln Arg Ala Ala Glu Ala Ile Asp Leu 
                245                 250                 255     


Gly Tyr Gln Ala Ala Val Ala Gln Leu Asp Arg Ile Trp Asp Ala Ile 
            260                 265                 270         


Asp Arg Ala Gly Ala Phe Val Ser 
        275                 280 


<210>  14
<211>  280
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:2 and encoded by SEQ ID NO:14

<400>  14

Met Pro Arg Ala Arg Glu Asp Trp Arg Ile Ala Met Ser Asp Lys Ala 
1               5                   10                  15      


Arg Ala Arg Asp Asn Val Lys Val Gly Val Ala Leu Gly Ser Gly Gly 
            20                  25                  30          


Ala Arg Gly Phe Ala His Ile Gly Val Leu Leu Ala Leu Ala Glu His 
        35                  40                  45              


Gly Val Pro Val His Ala Ile Ala Gly Ser Ser Met Gly Ala Leu Val 
    50                  55                  60                  


Ala Gly Val Tyr Ala Met Gly Val Pro Pro Arg Val Met Arg Ala Leu 
65                  70                  75                  80  


Ala Val Asn Leu Arg Arg Arg His Trp Leu Asp Phe Thr Val Pro Lys 
                85                  90                  95      


Met Gly Phe Ile Gln Gly Glu Lys Val Arg Thr Val Val Ala Thr Met 
            100                 105                 110         


Thr Arg Gln Gly Thr Phe Ala Asp Thr Ala Ile Pro Leu Ala Ile Val 
        115                 120                 125             


Ala Thr Asp Leu Ile Lys Arg Arg Leu Val Val Phe Arg Ser Gly Leu 
    130                 135                 140                 


Ile Ala Asp Ala Val Arg Ala Ser Ile Ser Ile Pro Gly Val Phe Val 
145                 150                 155                 160 


Pro Val Val Arg Asp Gly Ala Val Tyr Val Asp Gly Gly Val Leu Glu 
                165                 170                 175     


Arg Val Pro Val Gln Ala Cys Trp Asp Leu Gly Val Asp Leu Val Ile 
            180                 185                 190         


Ala Val Asp Val Gly Val Thr Pro Arg Gly Thr Pro Pro Thr Ser Ala 
        195                 200                 205             


Met Asp Val Ile Met Gln Ser Leu Glu Leu Met Gln Asp Glu Ala Leu 
    210                 215                 220                 


Arg Ala Arg Asp Arg Gly Ala Ser Leu Thr Leu Val Pro Glu Val Ser 
225                 230                 235                 240 


His Ile Gly Thr Ala Gln Leu Gln Arg Ala Ala Glu Ala Ile Asp Leu 
                245                 250                 255     


Gly Tyr Gln Ala Ala Val Ala Gln Leu Asp Arg Ile Trp Asp Ala Ile 
            260                 265                 270         


Asp Arg Ala Gly Ala Phe Val Ser 
        275                 280 


<210>  15
<211>  280
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:2 and encoded by SEQ ID NO:15

<400>  15

Met Pro Arg Ala Arg Glu Asp Trp Arg Ile Ala Met Ser Asp Lys Ala 
1               5                   10                  15      


Arg Ala Arg Asp Asn Val Lys Leu Gly Val Ala Leu Gly Ser Gly Gly 
            20                  25                  30          


Ala Lys Gly Phe Ala His Ile Gly Val Leu Leu Ala Leu Ala Glu His 
        35                  40                  45              


Gly Val Pro Val His Ala Ile Ala Gly Ser Ser Met Gly Ala Leu Val 
    50                  55                  60                  


Ala Gly Val Tyr Ala Met Gly Val Pro Pro Arg Val Met Arg Ala Leu 
65                  70                  75                  80  


Ala Val Asn Leu Arg Arg Arg His Trp Leu Asp Phe Thr Val Pro Lys 
                85                  90                  95      


Met Gly Phe Ile Gln Gly Glu Lys Val Arg Thr Val Val Ala Thr Met 
            100                 105                 110         


Thr Arg Gln Gly Thr Phe Ala Asp Thr Ala Ile Pro Leu Ala Ile Val 
        115                 120                 125             


Ala Thr Asp Leu Ile Lys Arg Arg Leu Val Val Phe Arg Ser Gly Leu 
    130                 135                 140                 


Ile Ala Asp Ala Val Arg Ala Ser Ile Ser Ile Pro Gly Val Phe Val 
145                 150                 155                 160 


Pro Val Val Arg Asp Gly Ala Val Tyr Val Asp Gly Gly Val Leu Glu 
                165                 170                 175     


Arg Val Pro Val Gln Ala Cys Trp Asp Leu Gly Val Asp Leu Val Ile 
            180                 185                 190         


Ala Val Asp Val Gly Val Thr Pro Arg Gly Thr Pro Pro Thr Ser Ala 
        195                 200                 205             


Met Asp Val Ile Met Gln Ser Leu Glu Leu Met Gln Asp Glu Ala Leu 
    210                 215                 220                 


Arg Ala Arg Asp Arg Gly Ala Ser Leu Thr Leu Val Pro Glu Val Ser 
225                 230                 235                 240 


His Ile Gly Thr Ala Gln Leu Gln Arg Ala Ala Glu Ala Ile Asp Leu 
                245                 250                 255     


Gly Tyr Gln Ala Ala Val Ala Gln Leu Asp Arg Ile Trp Asp Ala Ile 
            260                 265                 270         


Asp Arg Ala Gly Ala Phe Val Ser 
        275                 280 


<210>  16
<211>  280
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:2 and encoded by SEQ ID NO:16

<400>  16

Met Pro Arg Ala Arg Glu Asp Trp Arg Ile Ala Met Ser Asp Lys Ala 
1               5                   10                  15      


Arg Ala Arg Asp Asn Val Lys Val Gly Val Ala Leu Gly Ser Gly Gly 
            20                  25                  30          


Ala Lys Gly Phe Ala His Leu Gly Val Leu Leu Ala Leu Ala Glu His 
        35                  40                  45              


Gly Val Pro Val His Ala Ile Ala Gly Ser Ser Met Gly Ala Leu Val 
    50                  55                  60                  


Ala Gly Val Tyr Ala Met Gly Val Pro Pro Arg Val Met Arg Ala Leu 
65                  70                  75                  80  


Ala Val Asn Leu Arg Arg Arg His Trp Leu Asp Phe Thr Val Pro Lys 
                85                  90                  95      


Met Gly Phe Ile Gln Gly Glu Lys Val Arg Thr Val Val Ala Thr Met 
            100                 105                 110         


Thr Arg Gln Gly Thr Phe Ala Asp Thr Ala Ile Pro Leu Ala Ile Val 
        115                 120                 125             


Ala Thr Asp Leu Ile Lys Arg Arg Leu Val Val Phe Arg Ser Gly Leu 
    130                 135                 140                 


Ile Ala Asp Ala Val Arg Ala Ser Ile Ser Ile Pro Gly Val Phe Val 
145                 150                 155                 160 


Pro Val Val Arg Asp Gly Ala Val Tyr Val Asp Gly Gly Val Leu Glu 
                165                 170                 175     


Arg Val Pro Val Gln Ala Cys Trp Asp Leu Gly Val Asp Leu Val Ile 
            180                 185                 190         


Ala Val Asp Val Gly Val Thr Pro Arg Gly Thr Pro Pro Thr Ser Ala 
        195                 200                 205             


Met Asp Val Ile Met Gln Ser Leu Glu Leu Met Gln Asp Glu Ala Leu 
    210                 215                 220                 


Arg Ala Arg Asp Arg Gly Ala Ser Leu Thr Leu Val Pro Glu Val Ser 
225                 230                 235                 240 


His Ile Gly Thr Ala Gln Leu Gln Arg Ala Ala Glu Ala Ile Asp Leu 
                245                 250                 255     


Gly Tyr Gln Ala Ala Val Ala Gln Leu Asp Arg Ile Trp Asp Ala Ile 
            260                 265                 270         


Asp Arg Ala Gly Ala Phe Val Ser 
        275                 280 


<210>  17
<211>  280
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:2 and encoded by SEQ ID NO:17

<400>  17

Met Pro Arg Ala Arg Glu Asp Trp Arg Ile Ala Met Ser Asp Lys Ala 
1               5                   10                  15      


Arg Ala Arg Asp Asn Val Lys Val Gly Val Ala Leu Gly Ser Gly Gly 
            20                  25                  30          


Ala Lys Gly Phe Ala His Val Gly Val Leu Leu Ala Leu Ala Glu His 
        35                  40                  45              


Gly Val Pro Val His Ala Ile Ala Gly Ser Ser Met Gly Ala Leu Val 
    50                  55                  60                  


Ala Gly Val Tyr Ala Met Gly Val Pro Pro Arg Val Met Arg Ala Leu 
65                  70                  75                  80  


Ala Val Asn Leu Arg Arg Arg His Trp Leu Asp Phe Thr Val Pro Lys 
                85                  90                  95      


Met Gly Phe Ile Gln Gly Glu Lys Val Arg Thr Val Val Ala Thr Met 
            100                 105                 110         


Thr Arg Gln Gly Thr Phe Ala Asp Thr Ala Ile Pro Leu Ala Ile Val 
        115                 120                 125             


Ala Thr Asp Leu Ile Lys Arg Arg Leu Val Val Phe Arg Ser Gly Leu 
    130                 135                 140                 


Ile Ala Asp Ala Val Arg Ala Ser Ile Ser Ile Pro Gly Val Phe Val 
145                 150                 155                 160 


Pro Val Val Arg Asp Gly Ala Val Tyr Val Asp Gly Gly Val Leu Glu 
                165                 170                 175     


Arg Val Pro Val Gln Ala Cys Trp Asp Leu Gly Val Asp Leu Val Ile 
            180                 185                 190         


Ala Val Asp Val Gly Val Thr Pro Arg Gly Thr Pro Pro Thr Ser Ala 
        195                 200                 205             


Met Asp Val Ile Met Gln Ser Leu Glu Leu Met Gln Asp Glu Ala Leu 
    210                 215                 220                 


Arg Ala Arg Asp Arg Gly Ala Ser Leu Thr Leu Val Pro Glu Val Ser 
225                 230                 235                 240 


His Ile Gly Thr Ala Gln Leu Gln Arg Ala Ala Glu Ala Ile Asp Leu 
                245                 250                 255     


Gly Tyr Gln Ala Ala Val Ala Gln Leu Asp Arg Ile Trp Asp Ala Ile 
            260                 265                 270         


Asp Arg Ala Gly Ala Phe Val Ser 
        275                 280 


<210>  18
<211>  939
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  18
ttgacgaacg caggtcgctg ggtgttgcga attgcggtgg gcgtgatggt ccttgcaatc     60

ctggcctggc tcgccacgat ggccattggg tacgtggtgg cggaaaagtt gacgcatccc    120

gcgcgcaaac ccatctccac gtcgcccgcc gcgtatggcc tgaaatacga aagcatccgc    180

ttcccgtccc gcgtggatca cctgatgctc gccggctggc tgattcccgc cgcgagaccg    240

acggatcgca tcgtgattga agcgcacggg tatcggcaga accgcgtcct ggatcacccg    300

gcgctgccgg tggccaaggc gctgcacgac gccggttttg ccgtgctcat gttcgatttc    360

cgcgacgaag gcgaatcgcc cggcagcgag gtgaccgtcg gcgactacga gctgcgggat    420

cttctcggcg ccatcgatta cgcgcacaag ctcggctacg acgaggtcgg tctcatcggc    480

tactcgatgg gcgcgtcgac cgcgctcgaa gccaccgcgg ccgatccgtc tgtggacgcg    540

accatcgccg acagcccgtt tgacgatctc gagacctacc ttgaacagaa tctcagcgtg    600

tggaccaacc tgccctcgtt cccgttcaac ggagagattc tgtgggaggt caagcacctg    660

ttcggcctgg acccgaacgc ggtcgacccg ctgaagcagc tcgcgtcggc caagcctcgc    720

ccgattctcc tcatcgcggg gaccgccgac accaccattc cgccgtcgaa cagcgaagcg    780

ctgtacgacg agttgcatcg gcgcgatccg gaggacacgc tgtggctggt tccgggagcg    840

aaacacgtgg gcgcgtacga tgtggagcca aaggcgtatc tggagcgtgt cgtcgacttc    900

ttcgaagcgt acatgccggt gaaggtcacg tcgtcgtga                           939


<210>  19
<211>  312
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  19

Met Thr Asn Ala Gly Arg Trp Val Leu Arg Ile Ala Val Gly Val Met 
1               5                   10                  15      


Val Leu Ala Ile Leu Ala Trp Leu Ala Thr Met Ala Ile Gly Tyr Val 
            20                  25                  30          


Val Ala Glu Lys Leu Thr His Pro Ala Arg Lys Pro Ile Ser Thr Ser 
        35                  40                  45              


Pro Ala Ala Tyr Gly Leu Lys Tyr Glu Ser Ile Arg Phe Pro Ser Arg 
    50                  55                  60                  


Val Asp His Leu Met Leu Ala Gly Trp Leu Ile Pro Ala Ala Arg Pro 
65                  70                  75                  80  


Thr Asp Arg Ile Val Ile Glu Ala His Gly Tyr Arg Gln Asn Arg Val 
                85                  90                  95      


Leu Asp His Pro Ala Leu Pro Val Ala Lys Ala Leu His Asp Ala Gly 
            100                 105                 110         


Phe Ala Val Leu Met Phe Asp Phe Arg Asp Glu Gly Glu Ser Pro Gly 
        115                 120                 125             


Ser Glu Val Thr Val Gly Asp Tyr Glu Leu Arg Asp Leu Leu Gly Ala 
    130                 135                 140                 


Ile Asp Tyr Ala His Lys Leu Gly Tyr Asp Glu Val Gly Leu Ile Gly 
145                 150                 155                 160 


Tyr Ser Met Gly Ala Ser Thr Ala Leu Glu Ala Thr Ala Ala Asp Pro 
                165                 170                 175     


Ser Val Asp Ala Thr Ile Ala Asp Ser Pro Phe Asp Asp Leu Glu Thr 
            180                 185                 190         


Tyr Leu Glu Gln Asn Leu Ser Val Trp Thr Asn Leu Pro Ser Phe Pro 
        195                 200                 205             


Phe Asn Gly Glu Ile Leu Trp Glu Val Lys His Leu Phe Gly Leu Asp 
    210                 215                 220                 


Pro Asn Ala Val Asp Pro Leu Lys Gln Leu Ala Ser Ala Lys Pro Arg 
225                 230                 235                 240 


Pro Ile Leu Leu Ile Ala Gly Thr Ala Asp Thr Thr Ile Pro Pro Ser 
                245                 250                 255     


Asn Ser Glu Ala Leu Tyr Asp Glu Leu His Arg Arg Asp Pro Glu Asp 
            260                 265                 270         


Thr Leu Trp Leu Val Pro Gly Ala Lys His Val Gly Ala Tyr Asp Val 
        275                 280                 285             


Glu Pro Lys Ala Tyr Leu Glu Arg Val Val Asp Phe Phe Glu Ala Tyr 
    290                 295                 300                 


Met Pro Val Lys Val Thr Ser Ser 
305                 310         


<210>  20
<211>  313
<212>  PRT
<213>  Clostridium thermocellum 

<400>  20

Met Arg Ile Thr Val Leu Thr Tyr Ser Arg Gln Lys Ser His Ile Ile 
1               5                   10                  15      


Arg Lys Ile Ile Leu Phe Ile Val Leu Leu Ala Leu Ile Phe Ser Val 
            20                  25                  30          


Val Val Ser Ala Val Ser Val Ile Ala Gly Trp Lys Leu Ile His Pro 
        35                  40                  45              


Lys Arg Leu Asn Ile Leu Asp Phe Ser Ala Asn Ile Val Pro Ser Tyr 
    50                  55                  60                  


Thr Asp Val Ser Phe Lys Asp Ile Asn Asp Glu Phe Glu Leu Lys Gly 
65                  70                  75                  80  


Trp Tyr Phe Asn Val Thr Gly Ser Ser Lys Thr Val Ile Leu Ala His 
                85                  90                  95      


Gly Tyr Gly Lys Asn Arg Leu Asn Phe Gly Glu Asn Thr Ile His Leu 
            100                 105                 110         


Ile Lys Ser Leu Leu Asp Lys Gly Tyr Asn Val Leu Ala Phe Asp Phe 
        115                 120                 125             


Arg Asn Ser Gly Glu Ser Glu Gly Asn Lys Thr Thr Phe Gly Val Cys 
    130                 135                 140                 


Glu Lys Asn Asp Leu Leu Gly Ala Ile Gln Tyr Val Lys Asn Lys Gly 
145                 150                 155                 160 


Ser Glu Lys Ile Val Leu Met Gly Phe Ser Thr Gly Ala Ser Ala Cys 
                165                 170                 175     


Ile Leu Ala Ala Ala Glu Ser Asp Asp Val Asp Ala Val Ile Ala Glu 
            180                 185                 190         


Ser Pro Tyr Ser Asp Leu Asn Thr Tyr Phe Glu Gln Asn Val Asn Asn 
        195                 200                 205             


Leu Thr Asn Phe Pro Ala Ile Pro Phe Asn Lys Thr Ile Thr Phe Ala 
    210                 215                 220                 


Thr Phe Phe Leu Ala Asp Ile Lys Pro Asp Glu Ala Ser Pro Val Lys 
225                 230                 235                 240 


Ala Val Gln Ala Val Ser Pro Arg Pro Val Leu Leu Ile His Ser Lys 
                245                 250                 255     


Asp Asp Thr Lys Val Pro Val Glu Asn Ser Arg Leu Ile Tyr Lys Ala 
            260                 265                 270         


Ser Asn Pro Tyr Thr Thr Thr Phe Trp Glu Thr Ser Gly Ala Asp His 
        275                 280                 285             


Glu Glu Ile Tyr Gln Ala Asn Pro Glu Glu Tyr Val Lys Lys Val Thr 
    290                 295                 300                 


Asp Phe Leu Glu Lys Leu Ser Gln Thr 
305                 310             


<210>  21
<211>  321
<212>  PRT
<213>  Bacillus halodurans

<400>  21

Met Ala Asn Thr His Ser Pro Leu Ser Arg Pro Pro Val Lys Lys Arg 
1               5                   10                  15      


Trp Leu His Arg Val Ile Leu Ser Val Cys Val Leu Ala Phe Leu Gly 
            20                  25                  30          


Gly Leu Ser Ile Val Gly Ile Ser Val Tyr Val Gly Trp Asn Leu Ser 
        35                  40                  45              


His Pro Glu Arg Glu Val Ile Asp Glu Ser Pro Thr Asp Tyr Gly Leu 
    50                  55                  60                  


Leu Phe Glu Asp Val Val Phe Tyr Ser Glu Lys Asp Glu Val Glu Leu 
65                  70                  75                  80  


Lys Gly Trp Trp Ile Pro Ala Gln Asp Asn Gly Glu Glu Leu Gly Thr 
                85                  90                  95      


Asp Arg Ala Val Val Phe Ser His Gly Tyr Arg His Ser Arg Leu Gln 
            100                 105                 110         


Gly Glu Asn Asp Ile Leu Pro Phe Ala Lys Arg Leu Ala Gln Glu Gly 
        115                 120                 125             


Tyr His Leu Leu Leu Phe Asp Tyr Arg Gly Ser Gly Glu Ser Gly Gly 
    130                 135                 140                 


Thr Tyr Thr Thr Ile Gly Gln Tyr Glu Thr Asp Asp Leu Leu Ser Ala 
145                 150                 155                 160 


Ile Ala Phe Val Lys Ala Glu Lys His Val Glu Glu Ile Ala Val Ile 
                165                 170                 175     


Gly Trp Ser Met Gly Ala Val Ser Ala Ile Leu Ala Thr Gln Gln Ser 
            180                 185                 190         


Glu Asp Val Gln Ile Val Ile Ala Asp Ser Pro Phe Ala Asn Leu Arg 
        195                 200                 205             


Gln Tyr Leu Ser Glu Asn Leu Ser His Trp Ser Asp Leu Pro Asp Val 
    210                 215                 220                 


Pro Phe Thr Trp Val Val Leu Gln Thr Ile Pro Val Leu Ile Gly Ala 
225                 230                 235                 240 


Asp Ile Asp Gln Val Ser Pro Val Asp Ala Val Ser Pro Ile Gly Glu 
                245                 250                 255     


Thr Lys Leu Phe Leu Ile His Gly Arg Trp Asp Glu Ala Ile Pro His 
            260                 265                 270         


Arg Asp Ser Glu Ala Ile Phe Glu Ala Ala Asp Gly Gln Ala Glu Leu 
        275                 280                 285             


Trp Leu Pro Glu Asn Glu Gly His Val Lys Thr Ile Asn Glu Gln Ser 
    290                 295                 300                 


Glu Glu Tyr Glu Glu Arg Ile Leu Ala Phe Leu Glu Lys Ser Phe Thr 
305                 310                 315                 320 


Glu 
    


<210>  22
<211>  286
<212>  PRT
<213>  Pyrococcus abyssi 

<400>  22

Met Ile Trp Thr Trp Thr Ile Leu Leu Phe Leu Thr Ile Ile Phe Gly 
1               5                   10                  15      


Phe Phe Ala Phe Val Gly Tyr Lys Met Val Thr Pro Pro Arg Arg Val 
            20                  25                  30          


Gly Lys Trp Thr Pro Lys Asp Leu Gly Phe Asp Tyr Glu Lys Val Glu 
        35                  40                  45              


Phe Lys Ser Arg Asp Gly Ile Thr Leu Arg Gly Trp Trp Ile Asp Gln 
    50                  55                  60                  


Gly Lys Asp Glu Thr Val Ile Val Leu His Gly Tyr Thr Ala Ser Lys 
65                  70                  75                  80  


Trp Asn Glu Val Tyr Met Lys Pro Ala Ile Glu Ile Val Ala Asn Leu 
                85                  90                  95      


Gly Tyr Asn Val Leu Thr Phe Asp Phe Arg Ala His Gly Glu Ser Glu 
            100                 105                 110         


Gly Ser Lys Thr Thr Ile Gly Asp Lys Glu Ile Leu Asp Leu Ser Gly 
        115                 120                 125             


Ala Ile Asp Trp Leu Leu Ser Asn Thr Asn Thr Lys Lys Ile Ala Leu 
    130                 135                 140                 


Ile Gly Phe Ser Met Gly Ala Met Val Thr Ile Arg Ala Leu Ala Glu 
145                 150                 155                 160 


Asp Glu Arg Val Cys Cys Gly Ile Ala Asp Ser Pro Pro Ile Tyr Ile 
                165                 170                 175     


Asp Lys Thr Gly Ala Arg Gly Leu Lys Tyr Phe Ala Asn Leu Pro Glu 
            180                 185                 190         


Phe Leu Tyr Pro Ile Ile Lys Pro Phe Thr Lys Met Phe Ser Gly Ala 
        195                 200                 205             


Lys Glu Val Asn Ile Ile Asp Tyr Ala Asp Lys Val Arg Lys Pro Leu 
    210                 215                 220                 


Leu Ile Ile Ala Gly Gly Asn Asp Pro Leu Val Lys Val Glu Glu Val 
225                 230                 235                 240 


Glu Glu Phe Tyr Lys Arg Asn Lys Thr Ile Asn Pro Arg Ile Glu Val 
                245                 250                 255     


Trp Ile Thr Asp Ala Ala His Val Arg Thr Ile Val Lys Tyr Lys Glu 
            260                 265                 270         


Glu Trp Lys Arg Lys Val Gly Glu Phe Leu Arg Ala Asn Leu 
        275                 280                 285     


<210>  23
<211>  286
<212>  PRT
<213>  Pyrococcus abyssi

<400>  23

Met Ile Trp Thr Trp Thr Ile Leu Leu Phe Leu Thr Ile Ile Phe Gly 
1               5                   10                  15      


Phe Phe Ala Phe Val Gly Tyr Lys Met Val Thr Pro Pro Arg Arg Val 
            20                  25                  30          


Gly Lys Trp Thr Pro Lys Asp Leu Gly Phe Asp Tyr Glu Lys Val Glu 
        35                  40                  45              


Phe Lys Ser Arg Asp Gly Ile Thr Leu Arg Gly Trp Trp Ile Asp Gln 
    50                  55                  60                  


Gly Lys Asp Glu Thr Val Ile Val Leu His Gly Tyr Thr Ala Ser Lys 
65                  70                  75                  80  


Trp Asn Glu Val Tyr Met Lys Pro Ala Ile Glu Ile Val Ala Asn Leu 
                85                  90                  95      


Gly Tyr Asn Val Leu Thr Phe Asp Phe Arg Ala His Gly Glu Ser Glu 
            100                 105                 110         


Gly Ser Lys Thr Thr Ile Gly Asp Lys Glu Ile Leu Asp Leu Ser Gly 
        115                 120                 125             


Ala Ile Asp Trp Leu Leu Ser Asn Thr Asn Thr Lys Lys Ile Ala Leu 
    130                 135                 140                 


Ile Gly Phe Ser Met Gly Ala Met Val Thr Ile Arg Ala Leu Ala Glu 
145                 150                 155                 160 


Asp Glu Arg Val Cys Cys Gly Ile Ala Asp Ser Pro Pro Ile Tyr Ile 
                165                 170                 175     


Asp Lys Thr Gly Ala Arg Gly Leu Lys Tyr Phe Ala Asn Leu Pro Glu 
            180                 185                 190         


Phe Leu Tyr Pro Ile Ile Lys Pro Phe Thr Lys Met Phe Ser Gly Ala 
        195                 200                 205             


Lys Glu Val Asn Ile Ile Asp Tyr Ala Asp Lys Val Arg Lys Pro Leu 
    210                 215                 220                 


Leu Ile Ile Ala Gly Gly Asn Asp Pro Leu Val Lys Val Glu Glu Val 
225                 230                 235                 240 


Glu Glu Phe Tyr Lys Arg Asn Lys Thr Ile Asn Pro Arg Ile Glu Val 
                245                 250                 255     


Trp Ile Thr Asp Ala Ala His Val Arg Thr Ile Val Lys Tyr Lys Glu 
            260                 265                 270         


Glu Trp Lys Arg Lys Val Gly Glu Phe Leu Arg Ala Asn Leu 
        275                 280                 285     


<210>  24
<211>  366
<212>  PRT
<213>  Aspergillus nidulans FGSC A4

<400>  24

Met Ala Thr Leu Ser Lys His His Leu Gln Pro Leu Gly Pro Ile His 
1               5                   10                  15      


Pro Pro Arg Leu Gly Ser Ala Arg Ala Asn Glu Val Asp Ala Gln Pro 
            20                  25                  30          


Ile Phe Ile Pro Val His Asp Pro Leu Asp His Glu Ala Pro Ala Ile 
        35                  40                  45              


Leu His Ser Pro Arg Asp Tyr Asp Ala Ala Glu Ala Arg Asn Ser Ala 
    50                  55                  60                  


Val Ile Leu Val Ser Gly Ala Gly Gly Gly Val Ser Gly Pro Ser Gly 
65                  70                  75                  80  


Ile Tyr Pro Ser Leu Ala Asp Lys Leu Ala Ile Leu Leu Gly Val His 
                85                  90                  95      


Val Val Arg Leu Asp Tyr Arg Val Ala Ala Arg Thr Asp Tyr Cys Val 
            100                 105                 110         


Pro Asp Ile Ala Ala Thr Met Asp Tyr Leu Gln Asp Asn His Gly Ser 
        115                 120                 125             


Thr Arg Phe Val Val Val Gly Trp Ser Phe Gly Gly Ser Pro Cys Phe 
    130                 135                 140                 


Thr Ile Ala Ala Gln Gln Pro Asp Arg Val Leu Gly Val Ala Thr Val 
145                 150                 155                 160 


Ala Ser Gln Thr Ala Gln Thr Ser Gly Val Arg Lys Leu Ser Pro Arg 
                165                 170                 175     


Pro Leu Leu Val Leu His Gly Ser Gly Asp Thr Cys Leu Pro Gln Arg 
            180                 185                 190         


Cys Ser Glu Ser Leu Tyr Gln Gln Tyr Gly Asp Asp Pro Ser Gly Ser 
        195                 200                 205             


Arg Glu Ile Lys Ile Phe Lys Gly Asp Asn His Gly Leu Ser Arg Asn 
    210                 215                 220                 


Ala Pro Glu Ala Glu Gly Met Leu Leu Val Phe Ala Ala Lys Ala Leu 
225                 230                 235                 240 


Gly Leu Glu Asp Glu Leu Thr Ala Ala Ser Val Arg Ile Ala Ala Gln 
                245                 250                 255     


Asp Trp Val Gly Ser Glu Gly Glu Arg Met Lys Glu Met Ala Glu Gly 
            260                 265                 270         


His Asp Phe Glu Gly Gly Glu Ala Leu Asn His Asn Ser Ile Thr Ser 
        275                 280                 285             


Pro Gln Ala Leu Phe Asp His Val Glu Arg Glu Asp Arg Gln Gly Gly 
    290                 295                 300                 


Ser Gly Leu Ser Gly Ile Ala Gly Ser Tyr Glu Leu Tyr Ser Leu Ser 
305                 310                 315                 320 


His Arg Gln Arg Met Ala His Leu Pro Thr Ala Arg Thr Tyr Phe Ala 
                325                 330                 335     


Asp Ala Ile Ala Pro Glu Gly Phe Tyr Leu Val Tyr Met Thr Ile Val 
            340                 345                 350         


Arg Lys Gln Lys Thr Ala Arg Met Tyr Leu Lys Leu Asp Leu 
        355                 360                 365     


<210>  25
<211>  939
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 18

<400>  25
ttgacgaacg caggtcgctg ggtgttgcga attgcggtgg gcataatggt ccttgcaatc     60

ctggcctggc tcgccacgat ggccattggg tacgtggtgg cggaaaagtt gacgcatccc    120

gcgcgcaaac ccatctccac gtcgcccgcc gcgtatggcc tgaaatacga aagcatccgc    180

ttcccgtccc gcgtggatca cctgatgctc gccggctggc tgattcccgc cgcgagaccg    240

acggatcgca tcgtgattga agcgcacggg tatcggcaga accgcgtcct ggatcacccg    300

gcgctgccgg tggccaaggc gctgcacgac gccggttttg ccgtgctcat gttcgatttc    360

cgcgacgaag gcgaatcgcc cggcagcgag gtgaccgtcg gcgactacga gctgcgggat    420

cttctcggcg ccatcgatta cgcgcacaag ctcggctacg acgaggtcgg tctcatcggc    480

tactcgatgg gcgcgtcgac cgcgctcgaa gccaccgcgg ccgatccgtc tgtggacgcg    540

accatcgccg acagcccgtt tgacgatctc gagacctacc ttgaacagaa tctcagcgtg    600

tggaccaacc tgccctcgtt cccgttcaac ggagagattc tgtgggaggt caagcacctg    660

ttcggcctgg acccgaacgc ggtcgacccg ctgaagcagc tcgcgtcggc caagcctcgc    720

ccgattctcc tcatcgcggg gaccgccgac accaccattc cgccgtcgaa cagcgaagcg    780

ctgtacgacg agttgcatcg gcgcgatccg gaggacacgc tgtggctggt tccgggagcg    840

aaacacgtgg gcgcgtacga tgtggagcca aaggcgtatc tggagcgtgt cgtcgacttc    900

ttcgaagcgt acatgccggt gaaggtcacg tcgtcgtga                           939


<210>  26
<211>  939
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 18

<400>  26
ttgacgaacg caggtcgctg ggtgttgcga attgcggtgg gcttgatggt ccttgcaatc     60

ctggcctggc tcgccacgat ggccattggg tacgtggtgg cggaaaagtt gacgcatccc    120

gcgcgcaaac ccatctccac gtcgcccgcc gcgtatggcc tgaaatacga aagcatccgc    180

ttcccgtccc gcgtggatca cctgatgctc gccggctggc tgattcccgc cgcgagaccg    240

acggatcgca tcgtgattga agcgcacggg tatcggcaga accgcgtcct ggatcacccg    300

gcgctgccgg tggccaaggc gctgcacgac gccggttttg ccgtgctcat gttcgatttc    360

cgcgacgaag gcgaatcgcc cggcagcgag gtgaccgtcg gcgactacga gctgcgggat    420

cttctcggcg ccatcgatta cgcgcacaag ctcggctacg acgaggtcgg tctcatcggc    480

tactcgatgg gcgcgtcgac cgcgctcgaa gccaccgcgg ccgatccgtc tgtggacgcg    540

accatcgccg acagcccgtt tgacgatctc gagacctacc ttgaacagaa tctcagcgtg    600

tggaccaacc tgccctcgtt cccgttcaac ggagagattc tgtgggaggt caagcacctg    660

ttcggcctgg acccgaacgc ggtcgacccg ctgaagcagc tcgcgtcggc caagcctcgc    720

ccgattctcc tcatcgcggg gaccgccgac accaccattc cgccgtcgaa cagcgaagcg    780

ctgtacgacg agttgcatcg gcgcgatccg gaggacacgc tgtggctggt tccgggagcg    840

aaacacgtgg gcgcgtacga tgtggagcca aaggcgtatc tggagcgtgt cgtcgacttc    900

ttcgaagcgt acatgccggt gaaggtcacg tcgtcgtga                           939


<210>  27
<211>  939
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 18

<400>  27
ttgacgaacg caggtcgctg ggtgttgcga attgcggtgg gcgtgatgct ccttgcaatc     60

ctggcctggc tcgccacgat ggccattggg tacgtggtgg cggaaaagtt gacgcatccc    120

gcgcgcaaac ccatctccac gtcgcccgcc gcgtatggcc tgaaatacga aagcatccgc    180

ttcccgtccc gcgtggatca cctgatgctc gccggctggc tgattcccgc cgcgagaccg    240

acggatcgca tcgtgattga agcgcacggg tatcggcaga accgcgtcct ggatcacccg    300

gcgctgccgg tggccaaggc gctgcacgac gccggttttg ccgtgctcat gttcgatttc    360

cgcgacgaag gcgaatcgcc cggcagcgag gtgaccgtcg gcgactacga gctgcgggat    420

cttctcggcg ccatcgatta cgcgcacaag ctcggctacg acgaggtcgg tctcatcggc    480

tactcgatgg gcgcgtcgac cgcgctcgaa gccaccgcgg ccgatccgtc tgtggacgcg    540

accatcgccg acagcccgtt tgacgatctc gagacctacc ttgaacagaa tctcagcgtg    600

tggaccaacc tgccctcgtt cccgttcaac ggagagattc tgtgggaggt caagcacctg    660

ttcggcctgg acccgaacgc ggtcgacccg ctgaagcagc tcgcgtcggc caagcctcgc    720

ccgattctcc tcatcgcggg gaccgccgac accaccattc cgccgtcgaa cagcgaagcg    780

ctgtacgacg agttgcatcg gcgcgatccg gaggacacgc tgtggctggt tccgggagcg    840

aaacacgtgg gcgcgtacga tgtggagcca aaggcgtatc tggagcgtgt cgtcgacttc    900

ttcgaagcgt acatgccggt gaaggtcacg tcgtcgtga                           939


<210>  28
<211>  939
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 18

<400>  28
ttgacgaacg caggtcgctg ggtgttgcga attgcggtgg gcgtgatgat ccttgcaatc     60

ctggcctggc tcgccacgat ggccattggg tacgtggtgg cggaaaagtt gacgcatccc    120

gcgcgcaaac ccatctccac gtcgcccgcc gcgtatggcc tgaaatacga aagcatccgc    180

ttcccgtccc gcgtggatca cctgatgctc gccggctggc tgattcccgc cgcgagaccg    240

acggatcgca tcgtgattga agcgcacggg tatcggcaga accgcgtcct ggatcacccg    300

gcgctgccgg tggccaaggc gctgcacgac gccggttttg ccgtgctcat gttcgatttc    360

cgcgacgaag gcgaatcgcc cggcagcgag gtgaccgtcg gcgactacga gctgcgggat    420

cttctcggcg ccatcgatta cgcgcacaag ctcggctacg acgaggtcgg tctcatcggc    480

tactcgatgg gcgcgtcgac cgcgctcgaa gccaccgcgg ccgatccgtc tgtggacgcg    540

accatcgccg acagcccgtt tgacgatctc gagacctacc ttgaacagaa tctcagcgtg    600

tggaccaacc tgccctcgtt cccgttcaac ggagagattc tgtgggaggt caagcacctg    660

ttcggcctgg acccgaacgc ggtcgacccg ctgaagcagc tcgcgtcggc caagcctcgc    720

ccgattctcc tcatcgcggg gaccgccgac accaccattc cgccgtcgaa cagcgaagcg    780

ctgtacgacg agttgcatcg gcgcgatccg gaggacacgc tgtggctggt tccgggagcg    840

aaacacgtgg gcgcgtacga tgtggagcca aaggcgtatc tggagcgtgt cgtcgacttc    900

ttcgaagcgt acatgccggt gaaggtcacg tcgtcgtga                           939


<210>  29
<211>  939
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 18

<400>  29
ttgacgaacg caggtcgctg ggtgttgcga attgcggtgg gcgtgatggt ccttgcaatc     60

ctggcctggc tcgccacgat ggccgttggg tacgtggtgg cggaaaagtt gacgcatccc    120

gcgcgcaaac ccatctccac gtcgcccgcc gcgtatggcc tgaaatacga aagcatccgc    180

ttcccgtccc gcgtggatca cctgatgctc gccggctggc tgattcccgc cgcgagaccg    240

acggatcgca tcgtgattga agcgcacggg tatcggcaga accgcgtcct ggatcacccg    300

gcgctgccgg tggccaaggc gctgcacgac gccggttttg ccgtgctcat gttcgatttc    360

cgcgacgaag gcgaatcgcc cggcagcgag gtgaccgtcg gcgactacga gctgcgggat    420

cttctcggcg ccatcgatta cgcgcacaag ctcggctacg acgaggtcgg tctcatcggc    480

tactcgatgg gcgcgtcgac cgcgctcgaa gccaccgcgg ccgatccgtc tgtggacgcg    540

accatcgccg acagcccgtt tgacgatctc gagacctacc ttgaacagaa tctcagcgtg    600

tggaccaacc tgccctcgtt cccgttcaac ggagagattc tgtgggaggt caagcacctg    660

ttcggcctgg acccgaacgc ggtcgacccg ctgaagcagc tcgcgtcggc caagcctcgc    720

ccgattctcc tcatcgcggg gaccgccgac accaccattc cgccgtcgaa cagcgaagcg    780

ctgtacgacg agttgcatcg gcgcgatccg gaggacacgc tgtggctggt tccgggagcg    840

aaacacgtgg gcgcgtacga tgtggagcca aaggcgtatc tggagcgtgt cgtcgacttc    900

ttcgaagcgt acatgccggt gaaggtcacg tcgtcgtga                           939


<210>  30
<211>  312
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:19 and encoded by SEQ ID NO:25

<400>  30

Met Thr Asn Ala Gly Arg Trp Val Leu Arg Ile Ala Val Gly Ile Met 
1               5                   10                  15      


Val Leu Ala Ile Leu Ala Trp Leu Ala Thr Met Ala Ile Gly Tyr Val 
            20                  25                  30          


Val Ala Glu Lys Leu Thr His Pro Ala Arg Lys Pro Ile Ser Thr Ser 
        35                  40                  45              


Pro Ala Ala Tyr Gly Leu Lys Tyr Glu Ser Ile Arg Phe Pro Ser Arg 
    50                  55                  60                  


Val Asp His Leu Met Leu Ala Gly Trp Leu Ile Pro Ala Ala Arg Pro 
65                  70                  75                  80  


Thr Asp Arg Ile Val Ile Glu Ala His Gly Tyr Arg Gln Asn Arg Val 
                85                  90                  95      


Leu Asp His Pro Ala Leu Pro Val Ala Lys Ala Leu His Asp Ala Gly 
            100                 105                 110         


Phe Ala Val Leu Met Phe Asp Phe Arg Asp Glu Gly Glu Ser Pro Gly 
        115                 120                 125             


Ser Glu Val Thr Val Gly Asp Tyr Glu Leu Arg Asp Leu Leu Gly Ala 
    130                 135                 140                 


Ile Asp Tyr Ala His Lys Leu Gly Tyr Asp Glu Val Gly Leu Ile Gly 
145                 150                 155                 160 


Tyr Ser Met Gly Ala Ser Thr Ala Leu Glu Ala Thr Ala Ala Asp Pro 
                165                 170                 175     


Ser Val Asp Ala Thr Ile Ala Asp Ser Pro Phe Asp Asp Leu Glu Thr 
            180                 185                 190         


Tyr Leu Glu Gln Asn Leu Ser Val Trp Thr Asn Leu Pro Ser Phe Pro 
        195                 200                 205             


Phe Asn Gly Glu Ile Leu Trp Glu Val Lys His Leu Phe Gly Leu Asp 
    210                 215                 220                 


Pro Asn Ala Val Asp Pro Leu Lys Gln Leu Ala Ser Ala Lys Pro Arg 
225                 230                 235                 240 


Pro Ile Leu Leu Ile Ala Gly Thr Ala Asp Thr Thr Ile Pro Pro Ser 
                245                 250                 255     


Asn Ser Glu Ala Leu Tyr Asp Glu Leu His Arg Arg Asp Pro Glu Asp 
            260                 265                 270         


Thr Leu Trp Leu Val Pro Gly Ala Lys His Val Gly Ala Tyr Asp Val 
        275                 280                 285             


Glu Pro Lys Ala Tyr Leu Glu Arg Val Val Asp Phe Phe Glu Ala Tyr 
    290                 295                 300                 


Met Pro Val Lys Val Thr Ser Ser 
305                 310         


<210>  31
<211>  312
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:19 and encoded by SEQ ID NO:26

<400>  31

Met Thr Asn Ala Gly Arg Trp Val Leu Arg Ile Ala Val Gly Leu Met 
1               5                   10                  15      


Val Leu Ala Ile Leu Ala Trp Leu Ala Thr Met Ala Ile Gly Tyr Val 
            20                  25                  30          


Val Ala Glu Lys Leu Thr His Pro Ala Arg Lys Pro Ile Ser Thr Ser 
        35                  40                  45              


Pro Ala Ala Tyr Gly Leu Lys Tyr Glu Ser Ile Arg Phe Pro Ser Arg 
    50                  55                  60                  


Val Asp His Leu Met Leu Ala Gly Trp Leu Ile Pro Ala Ala Arg Pro 
65                  70                  75                  80  


Thr Asp Arg Ile Val Ile Glu Ala His Gly Tyr Arg Gln Asn Arg Val 
                85                  90                  95      


Leu Asp His Pro Ala Leu Pro Val Ala Lys Ala Leu His Asp Ala Gly 
            100                 105                 110         


Phe Ala Val Leu Met Phe Asp Phe Arg Asp Glu Gly Glu Ser Pro Gly 
        115                 120                 125             


Ser Glu Val Thr Val Gly Asp Tyr Glu Leu Arg Asp Leu Leu Gly Ala 
    130                 135                 140                 


Ile Asp Tyr Ala His Lys Leu Gly Tyr Asp Glu Val Gly Leu Ile Gly 
145                 150                 155                 160 


Tyr Ser Met Gly Ala Ser Thr Ala Leu Glu Ala Thr Ala Ala Asp Pro 
                165                 170                 175     


Ser Val Asp Ala Thr Ile Ala Asp Ser Pro Phe Asp Asp Leu Glu Thr 
            180                 185                 190         


Tyr Leu Glu Gln Asn Leu Ser Val Trp Thr Asn Leu Pro Ser Phe Pro 
        195                 200                 205             


Phe Asn Gly Glu Ile Leu Trp Glu Val Lys His Leu Phe Gly Leu Asp 
    210                 215                 220                 


Pro Asn Ala Val Asp Pro Leu Lys Gln Leu Ala Ser Ala Lys Pro Arg 
225                 230                 235                 240 


Pro Ile Leu Leu Ile Ala Gly Thr Ala Asp Thr Thr Ile Pro Pro Ser 
                245                 250                 255     


Asn Ser Glu Ala Leu Tyr Asp Glu Leu His Arg Arg Asp Pro Glu Asp 
            260                 265                 270         


Thr Leu Trp Leu Val Pro Gly Ala Lys His Val Gly Ala Tyr Asp Val 
        275                 280                 285             


Glu Pro Lys Ala Tyr Leu Glu Arg Val Val Asp Phe Phe Glu Ala Tyr 
    290                 295                 300                 


Met Pro Val Lys Val Thr Ser Ser 
305                 310         


<210>  32
<211>  312
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:19 and encoded by SEQ ID NO:27

<400>  32

Met Thr Asn Ala Gly Arg Trp Val Leu Arg Ile Ala Val Gly Val Met 
1               5                   10                  15      


Leu Leu Ala Ile Leu Ala Trp Leu Ala Thr Met Ala Ile Gly Tyr Val 
            20                  25                  30          


Val Ala Glu Lys Leu Thr His Pro Ala Arg Lys Pro Ile Ser Thr Ser 
        35                  40                  45              


Pro Ala Ala Tyr Gly Leu Lys Tyr Glu Ser Ile Arg Phe Pro Ser Arg 
    50                  55                  60                  


Val Asp His Leu Met Leu Ala Gly Trp Leu Ile Pro Ala Ala Arg Pro 
65                  70                  75                  80  


Thr Asp Arg Ile Val Ile Glu Ala His Gly Tyr Arg Gln Asn Arg Val 
                85                  90                  95      


Leu Asp His Pro Ala Leu Pro Val Ala Lys Ala Leu His Asp Ala Gly 
            100                 105                 110         


Phe Ala Val Leu Met Phe Asp Phe Arg Asp Glu Gly Glu Ser Pro Gly 
        115                 120                 125             


Ser Glu Val Thr Val Gly Asp Tyr Glu Leu Arg Asp Leu Leu Gly Ala 
    130                 135                 140                 


Ile Asp Tyr Ala His Lys Leu Gly Tyr Asp Glu Val Gly Leu Ile Gly 
145                 150                 155                 160 


Tyr Ser Met Gly Ala Ser Thr Ala Leu Glu Ala Thr Ala Ala Asp Pro 
                165                 170                 175     


Ser Val Asp Ala Thr Ile Ala Asp Ser Pro Phe Asp Asp Leu Glu Thr 
            180                 185                 190         


Tyr Leu Glu Gln Asn Leu Ser Val Trp Thr Asn Leu Pro Ser Phe Pro 
        195                 200                 205             


Phe Asn Gly Glu Ile Leu Trp Glu Val Lys His Leu Phe Gly Leu Asp 
    210                 215                 220                 


Pro Asn Ala Val Asp Pro Leu Lys Gln Leu Ala Ser Ala Lys Pro Arg 
225                 230                 235                 240 


Pro Ile Leu Leu Ile Ala Gly Thr Ala Asp Thr Thr Ile Pro Pro Ser 
                245                 250                 255     


Asn Ser Glu Ala Leu Tyr Asp Glu Leu His Arg Arg Asp Pro Glu Asp 
            260                 265                 270         


Thr Leu Trp Leu Val Pro Gly Ala Lys His Val Gly Ala Tyr Asp Val 
        275                 280                 285             


Glu Pro Lys Ala Tyr Leu Glu Arg Val Val Asp Phe Phe Glu Ala Tyr 
    290                 295                 300                 


Met Pro Val Lys Val Thr Ser Ser 
305                 310         


<210>  33
<211>  312
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:19 and encoded by SEQ ID NO28

<400>  33

Met Thr Asn Ala Gly Arg Trp Val Leu Arg Ile Ala Val Gly Val Met 
1               5                   10                  15      


Ile Leu Ala Ile Leu Ala Trp Leu Ala Thr Met Ala Ile Gly Tyr Val 
            20                  25                  30          


Val Ala Glu Lys Leu Thr His Pro Ala Arg Lys Pro Ile Ser Thr Ser 
        35                  40                  45              


Pro Ala Ala Tyr Gly Leu Lys Tyr Glu Ser Ile Arg Phe Pro Ser Arg 
    50                  55                  60                  


Val Asp His Leu Met Leu Ala Gly Trp Leu Ile Pro Ala Ala Arg Pro 
65                  70                  75                  80  


Thr Asp Arg Ile Val Ile Glu Ala His Gly Tyr Arg Gln Asn Arg Val 
                85                  90                  95      


Leu Asp His Pro Ala Leu Pro Val Ala Lys Ala Leu His Asp Ala Gly 
            100                 105                 110         


Phe Ala Val Leu Met Phe Asp Phe Arg Asp Glu Gly Glu Ser Pro Gly 
        115                 120                 125             


Ser Glu Val Thr Val Gly Asp Tyr Glu Leu Arg Asp Leu Leu Gly Ala 
    130                 135                 140                 


Ile Asp Tyr Ala His Lys Leu Gly Tyr Asp Glu Val Gly Leu Ile Gly 
145                 150                 155                 160 


Tyr Ser Met Gly Ala Ser Thr Ala Leu Glu Ala Thr Ala Ala Asp Pro 
                165                 170                 175     


Ser Val Asp Ala Thr Ile Ala Asp Ser Pro Phe Asp Asp Leu Glu Thr 
            180                 185                 190         


Tyr Leu Glu Gln Asn Leu Ser Val Trp Thr Asn Leu Pro Ser Phe Pro 
        195                 200                 205             


Phe Asn Gly Glu Ile Leu Trp Glu Val Lys His Leu Phe Gly Leu Asp 
    210                 215                 220                 


Pro Asn Ala Val Asp Pro Leu Lys Gln Leu Ala Ser Ala Lys Pro Arg 
225                 230                 235                 240 


Pro Ile Leu Leu Ile Ala Gly Thr Ala Asp Thr Thr Ile Pro Pro Ser 
                245                 250                 255     


Asn Ser Glu Ala Leu Tyr Asp Glu Leu His Arg Arg Asp Pro Glu Asp 
            260                 265                 270         


Thr Leu Trp Leu Val Pro Gly Ala Lys His Val Gly Ala Tyr Asp Val 
        275                 280                 285             


Glu Pro Lys Ala Tyr Leu Glu Arg Val Val Asp Phe Phe Glu Ala Tyr 
    290                 295                 300                 


Met Pro Val Lys Val Thr Ser Ser 
305                 310         


<210>  34
<211>  312
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:19 and encoded by SEQ ID NO:29

<400>  34

Met Thr Asn Ala Gly Arg Trp Val Leu Arg Ile Ala Val Gly Val Met 
1               5                   10                  15      


Val Leu Ala Ile Leu Ala Trp Leu Ala Thr Met Ala Val Gly Tyr Val 
            20                  25                  30          


Val Ala Glu Lys Leu Thr His Pro Ala Arg Lys Pro Ile Ser Thr Ser 
        35                  40                  45              


Pro Ala Ala Tyr Gly Leu Lys Tyr Glu Ser Ile Arg Phe Pro Ser Arg 
    50                  55                  60                  


Val Asp His Leu Met Leu Ala Gly Trp Leu Ile Pro Ala Ala Arg Pro 
65                  70                  75                  80  


Thr Asp Arg Ile Val Ile Glu Ala His Gly Tyr Arg Gln Asn Arg Val 
                85                  90                  95      


Leu Asp His Pro Ala Leu Pro Val Ala Lys Ala Leu His Asp Ala Gly 
            100                 105                 110         


Phe Ala Val Leu Met Phe Asp Phe Arg Asp Glu Gly Glu Ser Pro Gly 
        115                 120                 125             


Ser Glu Val Thr Val Gly Asp Tyr Glu Leu Arg Asp Leu Leu Gly Ala 
    130                 135                 140                 


Ile Asp Tyr Ala His Lys Leu Gly Tyr Asp Glu Val Gly Leu Ile Gly 
145                 150                 155                 160 


Tyr Ser Met Gly Ala Ser Thr Ala Leu Glu Ala Thr Ala Ala Asp Pro 
                165                 170                 175     


Ser Val Asp Ala Thr Ile Ala Asp Ser Pro Phe Asp Asp Leu Glu Thr 
            180                 185                 190         


Tyr Leu Glu Gln Asn Leu Ser Val Trp Thr Asn Leu Pro Ser Phe Pro 
        195                 200                 205             


Phe Asn Gly Glu Ile Leu Trp Glu Val Lys His Leu Phe Gly Leu Asp 
    210                 215                 220                 


Pro Asn Ala Val Asp Pro Leu Lys Gln Leu Ala Ser Ala Lys Pro Arg 
225                 230                 235                 240 


Pro Ile Leu Leu Ile Ala Gly Thr Ala Asp Thr Thr Ile Pro Pro Ser 
                245                 250                 255     


Asn Ser Glu Ala Leu Tyr Asp Glu Leu His Arg Arg Asp Pro Glu Asp 
            260                 265                 270         


Thr Leu Trp Leu Val Pro Gly Ala Lys His Val Gly Ala Tyr Asp Val 
        275                 280                 285             


Glu Pro Lys Ala Tyr Leu Glu Arg Val Val Asp Phe Phe Glu Ala Tyr 
    290                 295                 300                 


Met Pro Val Lys Val Thr Ser Ser 
305                 310         


<210>  35
<211>  2346
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  35
gtgggcatga ttcacgagca gacggatttc acaaccagtg aggcgatccg cccggatacg     60

ctgatctcgc cgccagatga ctgggctttt ctcgggcgac ccagccggtt tgatgtggat    120

cacgatggct gggcgacggt tcagtatgac gctggagtca tggtcggtgt cgccgcactc    180

gacgacaccg tgctacgcgt agcctactgc aggtcccctg gggagtggcc gacgagcaca    240

cctgccattg tggaacagat gtcgcagcgg cactcctggc ggctcgttca ggaagagcga    300

cgcgtgcaac tggaatgtgt tgccggatgg cagattcaaa tcaaccggga cgacggaaca    360

tggagtatac gccatctcgg ctttgggaca gccgtcgagg ccatcacgtg gtacaagcgc    420

aaaaaaggcg gcgcattgac gtttgcttcg ctcgacaatg cccggttcta tggacttggc    480

gaaaagccgg ggccccttga caagcggcac gaggcgtaca ccatgtggaa ttcggacgtt    540

tacgcgcctc acgtgccaga gatggaggcc ctatacctgt cgatcccgtt ctttttgcga    600

ttgcaagacc aaacggccgt tggcatcttt gtggataatc cagggcgatc ccgctttgac    660

ttcaggagca gataccctga cgtggaaata tcgacagaac gaggcgggtt ggacgtttat    720

ttcatcttcg gggcttcgct caaagatgtc attcgacgtt acacaaagct cacggggcga    780

atgccgatgc cacccaagtg ggcgctcggc tatcatcagt ctcggtactc gtacgagacc    840

cagagcgagg tcctgtcggt ggcgcaaacg tttgtcgagc gcgacattcc ggtggatgcc    900

ttgtatctgg atattcacta catggatgga tatcgggtgt tcacctttga tgagaggcga    960

tttcccgatc cggcacgcat gtgcgacgag ttgcggaagc ttggggtgcg cgttgtcccc   1020

atcgtggatc cgggggtgaa acaggatcct gaatatcccg tttacatgga cgggctagcc   1080

cacaaccact tctgccaaac cgccgagggt caagtgtatc ttggtgaggt atggcccgga   1140

ttgagtgcct ttcctgattt cgcgtcggag gaagtgcggg cgtggtgggg caagtggcat   1200

cgggtgtaca cccagatggg aattgagggc atatggaatg atatgaacga gccggctgtg   1260

ttcaatgaga cgaagaccat ggacgtgaac gtggtccacc gaggcgacgg acgattgtac   1320

acgcacggag aggtccacaa cctctatgga ttctggatgg ctgaagccac gtatcgcgga   1380

ctgaaagcgc agttggctgg caagcggcct tttgtgctca cgcgcgctgg ctacagcgga   1440

attcaacggt atgcggcggt gtggacgggc gacaaccgaa gcttttggga acatatggcc   1500

atggccatcc cgatggtgct caacatgggg atgtccggta ttccgctcgg gggcccagat   1560

gtgggcggtt tcgctcatca cgcttcaggt gaattgcttg cacgatggac gcaaatgggg   1620

gcgttctttc cgttctttcg aaatcacagt gccatgggaa cgcatcgaca ggaaccttgg   1680

gcattcggcc ctacgttcga agccgtcatt cgacgtgcca tccggctccg ttatcgtttc   1740

ctgccttatc tgtacacgct cgcacgggaa gcccatgaga caggtttacc catgatgcgg   1800

cccttggtgt tagagtatcc cgacgatcca aacacgcacc acgtcgatga tcagttcctc   1860

gtcggttccg atcttctcgt ggcacccatc ctcaagccgg gcatggccca tagaatggtc   1920

tatttgcccg atggagaatg gattgattat gagacgcgtg agcgatacca agggcgtcag   1980

tacatcttga cgtatgcgcc tctcgatcgt atccctctgt acgtgagggc agggagcgct   2040

atccccgtga acctcttgga gcggtcgggc gagacccagc taggatggga gatcttcgtg   2100

gacgccaacg gtcgagcctc gggtcgatgc tatgaggacg acggcgagac gtttagctat   2160

gaagacggcg cctactgtga tcgcgtgtta caggccctcg ccacctcgga aggaacactg   2220

atcgaatgtc atcttgttca aggatcagga gatggtggaa gtctcgagag cgttgttcgc   2280

gtgttcacac cagatgacgt tcgtgaggct cgtgcgcagg gcatatcgtt ttccatccat   2340

gtgtga                                                              2346


<210>  36
<211>  781
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  36

Met Gly Met Ile His Glu Gln Thr Asp Phe Thr Thr Ser Glu Ala Ile 
1               5                   10                  15      


Arg Pro Asp Thr Leu Ile Ser Pro Pro Asp Asp Trp Ala Phe Leu Gly 
            20                  25                  30          


Arg Pro Ser Arg Phe Asp Val Asp His Asp Gly Trp Ala Thr Val Gln 
        35                  40                  45              


Tyr Asp Ala Gly Val Met Val Gly Val Ala Ala Leu Asp Asp Thr Val 
    50                  55                  60                  


Leu Arg Val Ala Tyr Cys Arg Ser Pro Gly Glu Trp Pro Thr Ser Thr 
65                  70                  75                  80  


Pro Ala Ile Val Glu Gln Met Ser Gln Arg His Ser Trp Arg Leu Val 
                85                  90                  95      


Gln Glu Glu Arg Arg Val Gln Leu Glu Cys Val Ala Gly Trp Gln Ile 
            100                 105                 110         


Gln Ile Asn Arg Asp Asp Gly Thr Trp Ser Ile Arg His Leu Gly Phe 
        115                 120                 125             


Gly Thr Ala Val Glu Ala Ile Thr Trp Tyr Lys Arg Lys Lys Gly Gly 
    130                 135                 140                 


Ala Leu Thr Phe Ala Ser Leu Asp Asn Ala Arg Phe Tyr Gly Leu Gly 
145                 150                 155                 160 


Glu Lys Pro Gly Pro Leu Asp Lys Arg His Glu Ala Tyr Thr Met Trp 
                165                 170                 175     


Asn Ser Asp Val Tyr Ala Pro His Val Pro Glu Met Glu Ala Leu Tyr 
            180                 185                 190         


Leu Ser Ile Pro Phe Phe Leu Arg Leu Gln Asp Gln Thr Ala Val Gly 
        195                 200                 205             


Ile Phe Val Asp Asn Pro Gly Arg Ser Arg Phe Asp Phe Arg Ser Arg 
    210                 215                 220                 


Tyr Pro Asp Val Glu Ile Ser Thr Glu Arg Gly Gly Leu Asp Val Tyr 
225                 230                 235                 240 


Phe Ile Phe Gly Ala Ser Leu Lys Asp Val Ile Arg Arg Tyr Thr Lys 
                245                 250                 255     


Leu Thr Gly Arg Met Pro Met Pro Pro Lys Trp Ala Leu Gly Tyr His 
            260                 265                 270         


Gln Ser Arg Tyr Ser Tyr Glu Thr Gln Ser Glu Val Leu Ser Val Ala 
        275                 280                 285             


Gln Thr Phe Val Glu Arg Asp Ile Pro Val Asp Ala Leu Tyr Leu Asp 
    290                 295                 300                 


Ile His Tyr Met Asp Gly Tyr Arg Val Phe Thr Phe Asp Glu Arg Arg 
305                 310                 315                 320 


Phe Pro Asp Pro Ala Arg Met Cys Asp Glu Leu Arg Lys Leu Gly Val 
                325                 330                 335     


Arg Val Val Pro Ile Val Asp Pro Gly Val Lys Gln Asp Pro Glu Tyr 
            340                 345                 350         


Pro Val Tyr Met Asp Gly Leu Ala His Asn His Phe Cys Gln Thr Ala 
        355                 360                 365             


Glu Gly Gln Val Tyr Leu Gly Glu Val Trp Pro Gly Leu Ser Ala Phe 
    370                 375                 380                 


Pro Asp Phe Ala Ser Glu Glu Val Arg Ala Trp Trp Gly Lys Trp His 
385                 390                 395                 400 


Arg Val Tyr Thr Gln Met Gly Ile Glu Gly Ile Trp Asn Asp Met Asn 
                405                 410                 415     


Glu Pro Ala Val Phe Asn Glu Thr Lys Thr Met Asp Val Asn Val Val 
            420                 425                 430         


His Arg Gly Asp Gly Arg Leu Tyr Thr His Gly Glu Val His Asn Leu 
        435                 440                 445             


Tyr Gly Phe Trp Met Ala Glu Ala Thr Tyr Arg Gly Leu Lys Ala Gln 
    450                 455                 460                 


Leu Ala Gly Lys Arg Pro Phe Val Leu Thr Arg Ala Gly Tyr Ser Gly 
465                 470                 475                 480 


Ile Gln Arg Tyr Ala Ala Val Trp Thr Gly Asp Asn Arg Ser Phe Trp 
                485                 490                 495     


Glu His Met Ala Met Ala Ile Pro Met Val Leu Asn Met Gly Met Ser 
            500                 505                 510         


Gly Ile Pro Leu Gly Gly Pro Asp Val Gly Gly Phe Ala His His Ala 
        515                 520                 525             


Ser Gly Glu Leu Leu Ala Arg Trp Thr Gln Met Gly Ala Phe Phe Pro 
    530                 535                 540                 


Phe Phe Arg Asn His Ser Ala Met Gly Thr His Arg Gln Glu Pro Trp 
545                 550                 555                 560 


Ala Phe Gly Pro Thr Phe Glu Ala Val Ile Arg Arg Ala Ile Arg Leu 
                565                 570                 575     


Arg Tyr Arg Phe Leu Pro Tyr Leu Tyr Thr Leu Ala Arg Glu Ala His 
            580                 585                 590         


Glu Thr Gly Leu Pro Met Met Arg Pro Leu Val Leu Glu Tyr Pro Asp 
        595                 600                 605             


Asp Pro Asn Thr His His Val Asp Asp Gln Phe Leu Val Gly Ser Asp 
    610                 615                 620                 


Leu Leu Val Ala Pro Ile Leu Lys Pro Gly Met Ala His Arg Met Val 
625                 630                 635                 640 


Tyr Leu Pro Asp Gly Glu Trp Ile Asp Tyr Glu Thr Arg Glu Arg Tyr 
                645                 650                 655     


Gln Gly Arg Gln Tyr Ile Leu Thr Tyr Ala Pro Leu Asp Arg Ile Pro 
            660                 665                 670         


Leu Tyr Val Arg Ala Gly Ser Ala Ile Pro Val Asn Leu Leu Glu Arg 
        675                 680                 685             


Ser Gly Glu Thr Gln Leu Gly Trp Glu Ile Phe Val Asp Ala Asn Gly 
    690                 695                 700                 


Arg Ala Ser Gly Arg Cys Tyr Glu Asp Asp Gly Glu Thr Phe Ser Tyr 
705                 710                 715                 720 


Glu Asp Gly Ala Tyr Cys Asp Arg Val Leu Gln Ala Leu Ala Thr Ser 
                725                 730                 735     


Glu Gly Thr Leu Ile Glu Cys His Leu Val Gln Gly Ser Gly Asp Gly 
            740                 745                 750         


Gly Ser Leu Glu Ser Val Val Arg Val Phe Thr Pro Asp Asp Val Arg 
        755                 760                 765             


Glu Ala Arg Ala Gln Gly Ile Ser Phe Ser Ile His Val 
    770                 775                 780     


<210>  37
<211>  728
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  37

Met Val Gly Val Ala Ala Leu Asp Asp Thr Val Leu Arg Val Ala Tyr 
1               5                   10                  15      


Cys Arg Ser Pro Gly Glu Trp Pro Thr Ser Thr Pro Ala Ile Val Glu 
            20                  25                  30          


Gln Met Ser Gln Arg His Ser Trp Arg Leu Val Gln Glu Glu Arg Arg 
        35                  40                  45              


Val Gln Leu Glu Cys Val Ala Gly Trp Gln Ile Gln Ile Asn Arg Asp 
    50                  55                  60                  


Asp Gly Thr Trp Ser Ile Arg His Leu Gly Phe Gly Thr Ala Val Glu 
65                  70                  75                  80  


Ala Ile Thr Trp Tyr Lys Arg Lys Lys Gly Gly Ala Leu Thr Phe Ala 
                85                  90                  95      


Ser Leu Asp Asn Ala Arg Phe Tyr Gly Leu Gly Glu Lys Pro Gly Pro 
            100                 105                 110         


Leu Asp Lys Arg His Glu Ala Tyr Thr Met Trp Asn Ser Asp Val Tyr 
        115                 120                 125             


Ala Pro His Val Pro Glu Met Glu Ala Leu Tyr Leu Ser Ile Pro Phe 
    130                 135                 140                 


Phe Leu Arg Leu Gln Asp Gln Thr Ala Val Gly Ile Phe Val Asp Asn 
145                 150                 155                 160 


Pro Gly Arg Ser Arg Phe Asp Phe Arg Ser Arg Tyr Pro Asp Val Glu 
                165                 170                 175     


Ile Ser Thr Glu Arg Gly Gly Leu Asp Val Tyr Phe Ile Phe Gly Ala 
            180                 185                 190         


Ser Leu Lys Asp Val Ile Arg Arg Tyr Thr Lys Leu Thr Gly Arg Met 
        195                 200                 205             


Pro Met Pro Pro Lys Trp Ala Leu Gly Tyr His Gln Ser Arg Tyr Ser 
    210                 215                 220                 


Tyr Glu Thr Gln Ser Glu Val Leu Ser Val Ala Gln Thr Phe Val Glu 
225                 230                 235                 240 


Arg Asp Ile Pro Val Asp Ala Leu Tyr Leu Asp Ile His Tyr Met Asp 
                245                 250                 255     


Gly Tyr Arg Val Phe Thr Phe Asp Glu Arg Arg Phe Pro Asp Pro Ala 
            260                 265                 270         


Arg Met Cys Asp Glu Leu Arg Lys Leu Gly Val Arg Val Val Pro Ile 
        275                 280                 285             


Val Asp Pro Gly Val Lys Gln Asp Pro Glu Tyr Pro Val Tyr Met Asp 
    290                 295                 300                 


Gly Leu Ala His Asn His Phe Cys Gln Thr Ala Glu Gly Gln Val Tyr 
305                 310                 315                 320 


Leu Gly Glu Val Trp Pro Gly Leu Ser Ala Phe Pro Asp Phe Ala Ser 
                325                 330                 335     


Glu Glu Val Arg Ala Trp Trp Gly Lys Trp His Arg Val Tyr Thr Gln 
            340                 345                 350         


Met Gly Ile Glu Gly Ile Trp Asn Asp Met Asn Glu Pro Ala Val Phe 
        355                 360                 365             


Asn Glu Thr Lys Thr Met Asp Val Asn Val Val His Arg Gly Asp Gly 
    370                 375                 380                 


Arg Leu Tyr Thr His Gly Glu Val His Asn Leu Tyr Gly Phe Trp Met 
385                 390                 395                 400 


Ala Glu Ala Thr Tyr Arg Gly Leu Lys Ala Gln Leu Ala Gly Lys Arg 
                405                 410                 415     


Pro Phe Val Leu Thr Arg Ala Gly Tyr Ser Gly Ile Gln Arg Tyr Ala 
            420                 425                 430         


Ala Val Trp Thr Gly Asp Asn Arg Ser Phe Trp Glu His Met Ala Met 
        435                 440                 445             


Ala Ile Pro Met Val Leu Asn Met Gly Met Ser Gly Ile Pro Leu Gly 
    450                 455                 460                 


Gly Pro Asp Val Gly Gly Phe Ala His His Ala Ser Gly Glu Leu Leu 
465                 470                 475                 480 


Ala Arg Trp Thr Gln Met Gly Ala Phe Phe Pro Phe Phe Arg Asn His 
                485                 490                 495     


Ser Ala Met Gly Thr His Arg Gln Glu Pro Trp Ala Phe Gly Pro Thr 
            500                 505                 510         


Phe Glu Ala Val Ile Arg Arg Ala Ile Arg Leu Arg Tyr Arg Phe Leu 
        515                 520                 525             


Pro Tyr Leu Tyr Thr Leu Ala Arg Glu Ala His Glu Thr Gly Leu Pro 
    530                 535                 540                 


Met Met Arg Pro Leu Val Leu Glu Tyr Pro Asp Asp Pro Asn Thr His 
545                 550                 555                 560 


His Val Asp Asp Gln Phe Leu Val Gly Ser Asp Leu Leu Val Ala Pro 
                565                 570                 575     


Ile Leu Lys Pro Gly Met Ala His Arg Met Val Tyr Leu Pro Asp Gly 
            580                 585                 590         


Glu Trp Ile Asp Tyr Glu Thr Arg Glu Arg Tyr Gln Gly Arg Gln Tyr 
        595                 600                 605             


Ile Leu Thr Tyr Ala Pro Leu Asp Arg Ile Pro Leu Tyr Val Arg Ala 
    610                 615                 620                 


Gly Ser Ala Ile Pro Val Asn Leu Leu Glu Arg Ser Gly Glu Thr Gln 
625                 630                 635                 640 


Leu Gly Trp Glu Ile Phe Val Asp Ala Asn Gly Arg Ala Ser Gly Arg 
                645                 650                 655     


Cys Tyr Glu Asp Asp Gly Glu Thr Phe Ser Tyr Glu Asp Gly Ala Tyr 
            660                 665                 670         


Cys Asp Arg Val Leu Gln Ala Leu Ala Thr Ser Glu Gly Thr Leu Ile 
        675                 680                 685             


Glu Cys His Leu Val Gln Gly Ser Gly Asp Gly Gly Ser Leu Glu Ser 
    690                 695                 700                 


Val Val Arg Val Phe Thr Pro Asp Asp Val Arg Glu Ala Arg Ala Gln 
705                 710                 715                 720 


Gly Ile Ser Phe Ser Ile His Val 
                725             


<210>  38
<211>  787
<212>  PRT
<213>  Bacillus thermoamyloliquefaciens

<400>  38

Met Leu Glu Asp Thr Ser Phe Ala Ile Gln Pro Glu Gln Asp Asp Lys 
1               5                   10                  15      


Thr Gln Glu Thr His Arg Ile Asp Ile Gly Asn Met His Thr Phe Ser 
            20                  25                  30          


His Thr Glu His Val Phe Ser Phe His Cys Asp Thr Gly Ile Val Lys 
        35                  40                  45              


Ile Arg Phe Tyr Arg Glu Asp Ile Val Arg Ile Ala Phe Asn Pro Phe 
    50                  55                  60                  


Gly Glu Thr Ser Leu Ser Thr Ser Val Ala Val Val Lys Glu Pro Glu 
65                  70                  75                  80  


Lys Val Asp Ala Ser Val His Glu Thr Glu Glu Glu Val Thr Leu Thr 
                85                  90                  95      


Ser Ala Lys Gln Thr Val Val Leu Gln Lys Arg Pro Phe Arg Val Arg 
            100                 105                 110         


Ile Tyr Asp Asn His Gly Arg Leu Leu Val Ala Glu Gly Lys Lys Gly 
        115                 120                 125             


Met Ala Phe Thr Tyr Gln Gly Glu Val Cys Cys Phe Lys Met Met Asp 
    130                 135                 140                 


Glu Ala Asp His Phe Tyr Gly Phe Gly Glu Lys Thr Gly Phe Leu Asp 
145                 150                 155                 160 


Lys Arg Gly Glu Thr Met Thr Met Trp Asn Thr Asp Val Tyr Ala Pro 
                165                 170                 175     


His Asn Pro Glu Thr Asp Pro Leu Tyr Gln Ser His Pro Tyr Phe Met 
            180                 185                 190         


Thr Val Arg Asn Gly Ser Ala His Gly Ile Phe Phe Asp Asn Thr Tyr 
        195                 200                 205             


Lys Thr Thr Phe Asp Phe Gln Thr Ala Thr Asp Glu Tyr Cys Phe Ser 
    210                 215                 220                 


Ala Glu Gly Gly Ala Ile Asp Tyr Tyr Val Phe Ala Gly Pro Thr Pro 
225                 230                 235                 240 


Lys Asp Val Leu Glu Gln Tyr Thr Asp Leu Thr Gly Arg Met Pro Leu 
                245                 250                 255     


Pro Pro Lys Trp Ala Leu Gly Tyr His Gln Ser Arg Tyr Ser Tyr Glu 
            260                 265                 270         


Thr Glu Gln Glu Val Arg Glu Ile Ala Gln Thr Phe Ile Glu Lys Asp 
        275                 280                 285             


Ile Pro Leu Asp Val Ile Tyr Leu Asp Ile His Tyr Met Asn Gly Tyr 
    290                 295                 300                 


Arg Val Phe Thr Phe Asp Arg Asn Arg Phe Pro Asn Leu Lys Gln Leu 
305                 310                 315                 320 


Ile Ala Asp Leu Lys Gln Lys Gly Ile Arg Val Val Pro Ile Val Asp 
                325                 330                 335     


Pro Gly Val Lys Glu Asp Pro Glu Tyr Val Ile Tyr Gln Glu Gly Ile 
            340                 345                 350         


Arg His Asp Tyr Phe Cys Lys Tyr Ile Glu Gly Asn Val Tyr Phe Gly 
        355                 360                 365             


Glu Val Trp Pro Gly Lys Ser Ala Phe Pro Asp Phe Thr Asn Lys Lys 
    370                 375                 380                 


Val Arg Lys Trp Trp Gly Glu Lys His Gln Phe Tyr Thr Asp Leu Gly 
385                 390                 395                 400 


Ile Glu Gly Ile Trp Asn Asp Met Asn Glu Pro Ser Val Phe Asn Glu 
                405                 410                 415     


Thr Lys Thr Met Asp Val Lys Val Ile His Asp Asn Asp Gly Asp Pro 
            420                 425                 430         


Lys Thr His Arg Glu Leu His Asn Val Tyr Gly Phe Met Met Gly Glu 
        435                 440                 445             


Ala Thr Tyr Lys Gly Met Lys Lys Leu Leu Asn Gly Lys Arg Pro Phe 
    450                 455                 460                 


Leu Leu Thr Arg Ala Gly Phe Ser Gly Ile Gln Arg Tyr Ala Ala Val 
465                 470                 475                 480 


Trp Thr Gly Asp Asn Arg Ser Phe Trp Glu His Leu Gln Met Ser Leu 
                485                 490                 495     


Pro Met Cys Met Asn Leu Gly Leu Ser Gly Val Ala Phe Cys Gly Pro 
            500                 505                 510         


Asp Val Gly Gly Phe Ala His Asn Thr Asn Gly Glu Leu Leu Thr Arg 
        515                 520                 525             


Trp Met Gln Val Gly Ala Phe Thr Pro Tyr Phe Arg Asn His Cys Ala 
    530                 535                 540                 


Ile Gly Phe Arg Arg Gln Glu Pro Trp Ala Phe Gly Glu Lys Tyr Glu 
545                 550                 555                 560 


Arg Ile Ile Lys Lys Tyr Ile Arg Leu Arg Tyr Gln Trp Leu Pro His 
                565                 570                 575     


Leu Tyr Thr Leu Phe Ala Glu Ala His Glu Thr Gly Ala Pro Val Met 
            580                 585                 590         


Arg Pro Leu Phe Phe Glu Tyr Pro Asp Asp Glu Asn Thr Tyr Asn Leu 
        595                 600                 605             


Tyr Asp Glu Phe Leu Val Gly Ala Asn Val Leu Ile Ala Pro Ile Met 
    610                 615                 620                 


Thr Pro Ser Thr Thr Arg Arg Val Ala Tyr Phe Pro Lys Gly Asn Trp 
625                 630                 635                 640 


Val Asp Tyr Trp Thr Gly Glu Val Leu Glu Gly Gly Gln Tyr His Leu 
                645                 650                 655     


Ile Ser Ala Asp Leu Glu Thr Leu Pro Ile Phe Ile Lys Gln Gly Ser 
            660                 665                 670         


Ala Ile Ala Leu Gly Asp Val Lys Arg Ser Thr Glu Met Pro Asp Glu 
        675                 680                 685             


His Arg Thr Val His Ile Tyr Lys Ala Asn Gly Gly Lys Ala Thr Tyr 
    690                 695                 700                 


Val Leu Tyr Asp Asp Asp Gly Gln Thr Phe Ser Tyr Glu Lys Gly Asp 
705                 710                 715                 720 


Tyr Leu Arg Met Tyr Ile Glu Val Glu Tyr Gly Glu Asn Ser Val His 
                725                 730                 735     


Ile Val Thr Lys Ser Glu Gly Thr Tyr Gln Pro Ser Trp Lys Leu Ser 
            740                 745                 750         


Phe Ala Ile His His Ala Thr Glu Gln Thr Lys Val Thr Ile Asp Gly 
        755                 760                 765             


Asn Glu Gln Asn Ala Ile Phe Asp Pro His Gln Arg Ile Leu Leu Ile 
    770                 775                 780                 


Gln Ser Glu 
785         


<210>  39
<211>  779
<212>  PRT
<213>  Bacillus NRRL B-14911

<400>  39

Met Asn Asp Thr Ser Phe Ala Ile His Pro Gly Lys Ser Arg Lys Ile 
1               5                   10                  15      


Glu Asn Ser Asp Tyr Gln Glu Ala Gly Asp Val Leu Ala Ile Glu Glu 
            20                  25                  30          


Cys Arg Asn Gly Leu Lys Ala Arg Thr Glu Thr Gly Glu Leu Arg Ile 
        35                  40                  45              


Val Phe Tyr Ala Asn Glu Ile Val Arg Ile Thr Met Asn Phe Phe Gly 
    50                  55                  60                  


Glu Ala Asp Ala Gly Thr Ser Pro Ala Val Ile Gly Gly Leu Gln Glu 
65                  70                  75                  80  


Val Lys Leu Glu His Tyr Glu Ser Gly Asp Gln Ala Glu Val Lys Thr 
                85                  90                  95      


Ser Cys Leu Thr Val Lys Leu Thr Lys Ser Pro Leu Arg Ile Thr Val 
            100                 105                 110         


Ala Asp Ala Glu Gly Arg Val Leu Ala Gly Glu Asn Gln Lys Gly Met 
        115                 120                 125             


Gly Tyr Lys His Ser Lys Glu Val Ile Cys Phe Lys Asn Met Glu Glu 
    130                 135                 140                 


Ser Asp Gln Phe Tyr Gly Phe Gly Glu Lys Thr Gly Phe Leu Asn Lys 
145                 150                 155                 160 


Arg Gly Glu Lys Leu Val Met Trp Asn Ser Asp Val Tyr Ala Pro His 
                165                 170                 175     


Asn Pro Glu Thr Asp Pro Leu Tyr Gln Ser Ile Pro Phe Phe Leu Thr 
            180                 185                 190         


Leu Arg Glu Gly Gln Ala His Gly Ile Phe Phe Asp Asn Thr Phe Arg 
        195                 200                 205             


Ala Glu Phe Asp Met Arg Gly Asp Glu Phe Tyr Ser Phe Ser Ala Asp 
    210                 215                 220                 


Gly Gly Gln Leu Asp Tyr Tyr Leu Met Ala Gly Pro Ser Pro Lys Asp 
225                 230                 235                 240 


Val Ile Arg Gln Tyr Thr Ser Leu Thr Gly Arg Met Pro Leu Pro Ala 
                245                 250                 255     


Lys Trp Ala Ile Gly Tyr His Gln Ser Arg Tyr Ser Tyr Glu Ser Gln 
            260                 265                 270         


Gln Glu Val Met Glu Leu Ala Ala Ala Phe Lys Glu Lys Gly Ile Pro 
        275                 280                 285             


Leu Asp Ser Ile His Leu Asp Ile His Tyr Met Asp Glu Tyr Arg Val 
    290                 295                 300                 


Phe Thr Phe Asp Arg Asp Lys Phe Pro Asp Pro Glu Lys Met Ile Ser 
305                 310                 315                 320 


Asp Leu Lys Glu Met Gly Ile His Ile Val Pro Ile Val Asp Pro Gly 
                325                 330                 335     


Val Lys Glu Asp Pro Glu Tyr Met Val Tyr Lys Gln Gly Ile Gln Glu 
            340                 345                 350         


Asp Leu Phe Cys Lys Tyr Leu Glu Gly Asn Val Tyr Tyr Gly Asp Val 
        355                 360                 365             


Trp Pro Gly Asn Ser Val Phe Pro Asp Phe Thr Ser Lys Lys Val Arg 
    370                 375                 380                 


Asp Trp Trp Gly Ser Leu His Ser Tyr Tyr Thr Glu Leu Gly Ile Glu 
385                 390                 395                 400 


Gly Ile Trp Asn Asp Met Asn Glu Pro Ala Val Phe Asn Glu Ser Lys 
                405                 410                 415     


Thr Met Asp Leu Lys Val Met His Asp Asn Asp Gly Asn Pro Arg Thr 
            420                 425                 430         


His Lys Glu Leu His Asn Leu Tyr Gly Leu Leu Met Gly Lys Ser Thr 
        435                 440                 445             


Tyr Glu Gly Met Lys Arg Asn Leu Lys Gly Lys Arg Pro Phe Leu Leu 
    450                 455                 460                 


Thr Arg Ala Gly Tyr Ser Gly Val Gln Arg Tyr Ala Ala Val Trp Thr 
465                 470                 475                 480 


Gly Asp Asn Arg Ser Phe Trp Glu His Leu Gln Met Ser Leu Pro Met 
                485                 490                 495     


Val Met Asn Leu Gly Val Ser Gly Ile Pro Phe Ser Gly Pro Asp Val 
            500                 505                 510         


Gly Gly Phe Ala His Asp Ser Asn Gly Glu Leu Leu Ala Arg Trp Thr 
        515                 520                 525             


Gln Ala Gly Ala Phe Thr Pro Phe Phe Arg Asn His Ser Val Leu Gly 
    530                 535                 540                 


Ser Ala Arg Gln Glu Pro Trp Ala Phe Gly Glu Lys Tyr Glu Ala Ile 
545                 550                 555                 560 


Ile Arg Lys Tyr Ile Glu Leu Arg Tyr Thr Trp Met Pro His Leu Tyr 
                565                 570                 575     


Ser Leu Phe Ala Glu Ala His Lys Glu Gly Thr Pro Val Met Arg Pro 
            580                 585                 590         


Leu Phe Leu Glu Phe Pro Glu Asp Glu His Thr Trp Asn Leu Ser Asp 
        595                 600                 605             


Gln Phe Met Ile Gly Asp Asn Val Ile Ile Ala Pro Ile Met Gln Pro 
    610                 615                 620                 


Gly Thr Phe His Arg Ala Val Tyr Leu Pro Glu Gly Met Trp Thr Asp 
625                 630                 635                 640 


Tyr Trp Thr Gly Ser Thr Tyr Glu Gly Lys Lys His His Leu Ile Lys 
                645                 650                 655     


Ala Pro Leu Glu Thr Leu Pro Ile Phe Ile Lys Lys Gly Thr Met Ala 
            660                 665                 670         


Ala His Gly Glu Ala Gly Ala Ala Gly Pro Leu Thr Leu His Leu Tyr 
        675                 680                 685             


Tyr Glu Glu Gly Ser Glu Cys Ser Tyr Thr Leu Tyr Glu Asp Asp Gly 
    690                 695                 700                 


Glu Thr Phe Ala Tyr Glu Glu Gly Glu Tyr Arg Glu Ile Cys Phe Lys 
705                 710                 715                 720 


Val Lys Cys Glu Glu Gly Thr Val Tyr Leu Asn Ser Ala Ile Ala Gly 
                725                 730                 735     


Thr Tyr Glu Pro Val Trp Ser Thr Val Gln Leu Ala Val His Ser Arg 
            740                 745                 750         


Glu Asn Val Arg Leu Lys Ile Gly Ser Ser Thr Leu Leu Pro Glu Lys 
        755                 760                 765             


Ile Glu Glu Gly Arg His Tyr Phe Ile Leu Ser 
    770                 775                 


<210>  40
<211>  752
<212>  PRT
<213>  Thermoanaerobacter ethanolicus 

<400>  40

Met Tyr Gln Lys Thr Ser Glu Gly Ile Val Val Arg Asn Glu Gly Lys 
1               5                   10                  15      


Lys Leu Glu Leu Arg Val Leu Gly Asp Lys Ile Ile Asn Val Phe Val 
            20                  25                  30          


Ser Asp Lys Glu Glu Lys Arg Lys Asp Thr Ile Ala Ile Glu Arg Lys 
        35                  40                  45              


Glu Tyr Asp Ile Pro Glu Phe Ser Val Arg Lys Glu Leu Glu Ser Ile 
    50                  55                  60                  


Leu Ile Glu Thr Asp Ser Leu Lys Val Lys Ile Asn Lys Asn Asp Leu 
65                  70                  75                  80  


Ser Val Ser Phe Leu Asp Lys Asn Glu Asn Ile Ile Asn Glu Asp Tyr 
                85                  90                  95      


Asn Gly Gly Val Lys Phe Ser Glu Thr Asp Val Arg Cys Tyr Lys Lys 
            100                 105                 110         


Leu Arg Glu Asp His Phe Tyr Gly Phe Gly Glu Lys Ala Gly Tyr Leu 
        115                 120                 125             


Asp Lys Lys Gly Glu Arg Leu Glu Met Trp Asn Thr Asp Glu Phe Met 
    130                 135                 140                 


Thr His Asn Gln Thr Thr Lys Leu Leu Tyr Glu Ser Tyr Pro Phe Phe 
145                 150                 155                 160 


Ile Gly Met Asn Asp Tyr His Thr Tyr Gly Ile Phe Leu Asp Asn Ser 
                165                 170                 175     


Phe Arg Ser Phe Phe Asp Met Gly Gln Glu Cys Gln Glu Tyr Tyr Tyr 
            180                 185                 190         


Phe Gly Ala Tyr Gly Gly Gln Met Asn Tyr Tyr Phe Ile Tyr Gly Glu 
        195                 200                 205             


Asp Ile Lys Glu Val Val Glu Asn Tyr Thr Tyr Leu Thr Gly Arg Ile 
    210                 215                 220                 


Asn Leu Pro Pro Leu Trp Ala Leu Gly Asn Gln Gln Ser Arg Tyr Ser 
225                 230                 235                 240 


Tyr Thr Pro Gln Glu Arg Val Leu Glu Ile Ala Lys Thr Phe Arg Glu 
                245                 250                 255     


Lys Asp Ile Pro Cys Asp Val Ile Tyr Leu Asp Ile Asp Tyr Met Glu 
            260                 265                 270         


Gly Tyr Arg Val Phe Thr Trp Asn Lys Asp Thr Phe Lys Asn Tyr Lys 
        275                 280                 285             


Glu Met Leu Lys Gln Leu Lys Glu Met Gly Phe Lys Val Val Thr Ile 
    290                 295                 300                 


Val Asp Pro Gly Val Lys Arg Asp Tyr Asp Tyr His Val Tyr Arg Glu 
305                 310                 315                 320 


Gly Ile Glu Glu Asp Tyr Phe Val Lys Asp Lys Tyr Gly Ile Thr Tyr 
                325                 330                 335     


Val Gly Lys Val Trp Pro Gly Glu Ala Cys Phe Pro Asp Phe Leu Gln 
            340                 345                 350         


Glu Glu Val Arg Tyr Trp Trp Gly Glu Lys His Arg Glu Phe Ile Lys 
        355                 360                 365             


Asp Gly Ile Asp Gly Ile Trp Asn Asp Met Asn Glu Pro Ala Val Phe 
    370                 375                 380                 


Glu Thr Pro Thr Lys Thr Met Pro Glu Asp Asn Ile His Ile Leu Asp 
385                 390                 395                 400 


Gly Glu Lys Val Leu His Lys Glu Ala His Asn Val Tyr Ala Asn Tyr 
                405                 410                 415     


Met Ala Met Ala Thr Arg Asp Gly Leu Leu Arg Ile Arg Pro Asn Glu 
            420                 425                 430         


Arg Pro Phe Val Leu Thr Arg Ala Ala Phe Ser Gly Ile Gln Arg Tyr 
        435                 440                 445             


Ala Ala Met Trp Thr Gly Asp Asn Arg Ser Leu Tyr Glu His Leu Leu 
    450                 455                 460                 


Met Met Met Pro Met Leu Ile Asn Ile Gly Leu Ser Gly Gln Pro Phe 
465                 470                 475                 480 


Ala Gly Ala Asp Val Gly Gly Phe Glu Gly Asp Cys His Glu Glu Leu 
                485                 490                 495     


Phe Ile Arg Trp Ile Glu Ala Ala Thr Phe Thr Pro Phe Leu Arg Val 
            500                 505                 510         


His Ser Ala Ile Gly Thr Lys Asp Gln Glu Pro Trp Ser Phe Gly Lys 
        515                 520                 525             


Arg Cys Glu Asp Ile Ser Arg Lys Tyr Ile Lys Met Arg Tyr Glu Ile 
    530                 535                 540                 


Leu Pro Tyr Leu Tyr Asp Leu Phe Tyr Ile Ala Ser Gln Lys Gly Tyr 
545                 550                 555                 560 


Pro Ile Met Arg Pro Leu Val Phe Glu Tyr Gln Glu Asp Glu Asn Thr 
                565                 570                 575     


His Lys Ile Tyr Asp Glu Phe Leu Leu Gly Asp Asn Leu Leu Val Ala 
            580                 585                 590         


Pro Ile Tyr Leu Pro Ser Lys Glu Lys Arg Glu Val Tyr Leu Pro Lys 
        595                 600                 605             


Gly Ile Trp Tyr Asp Tyr Trp Thr Gly Lys Glu Phe Lys Gly Glu Ser 
    610                 615                 620                 


Tyr Tyr Leu Val Asp Ala Pro Ile Asp Ile Ile Pro Leu Phe Val Lys 
625                 630                 635                 640 


Glu Gly Gly Ile Leu Leu Lys Arg Glu Pro Gln Ser Phe Val Glu Glu 
                645                 650                 655     


Lys Glu Ile Lys Glu Ile Ile Val Glu Ile Tyr Arg Gly Glu Glu Gly 
            660                 665                 670         


His Tyr Leu His Tyr Glu Asp Asp Gly Lys Ser Phe Asp Tyr Thr Lys 
        675                 680                 685             


Gly Val Tyr Asn Leu Phe Asp Ile Ser Phe Cys Tyr Lys Glu Gly Arg 
    690                 695                 700                 


Met Asp Ile Lys Phe Asp Lys Ile His Phe Gly Tyr Asp Lys Gly Val 
705                 710                 715                 720 


Lys Lys Tyr Lys Phe Ile Phe Lys Asn Phe Gly Asp Ile Lys Glu Ile 
                725                 730                 735     


Lys Ile Asn Gly Glu Lys Val Gly Lys Glu Asn Cys Glu Ile Glu Leu 
            740                 745                 750         


<210>  41
<211>  2346
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 35

<400>  41
gtgggcatga ttcacgagca gacggatttc acaaccagtg aggcgatccg cccggatacg     60

ctgatctcgc cgccagatga ctgggctttt ctcgggcgac ccagccggtt tgatgtggat    120

cacgatggct gggcgacgct tcagtatgac gctggagtca tggtcggtgt cgccgcactc    180

gacgacaccg tgctacgcgt agcctactgc aggtcccctg gggagtggcc gacgagcaca    240

cctgccattg tggaacagat gtcgcagcgg cactcctggc ggctcgttca ggaagagcga    300

cgcgtgcaac tggaatgtgt tgccggatgg cagattcaaa tcaaccggga cgacggaaca    360

tggagtatac gccatctcgg ctttgggaca gccgtcgagg ccatcacgtg gtacaagcgc    420

aaaaaaggcg gcgcattgac gtttgcttcg ctcgacaatg cccggttcta tggacttggc    480

gaaaagccgg ggccccttga caagcggcac gaggcgtaca ccatgtggaa ttcggacgtt    540

tacgcgcctc acgtgccaga gatggaggcc ctatacctgt cgatcccgtt ctttttgcga    600

ttgcaagacc aaacggccgt tggcatcttt gtggataatc cagggcgatc ccgctttgac    660

ttcaggagca gataccctga cgtggaaata tcgacagaac gaggcgggtt ggacgtttat    720

ttcatcttcg gggcttcgct caaagatgtc attcgacgtt acacaaagct cacggggcga    780

atgccgatgc cacccaagtg ggcgctcggc tatcatcagt ctcggtactc gtacgagacc    840

cagagcgagg tcctgtcggt ggcgcaaacg tttgtcgagc gcgacattcc ggtggatgcc    900

ttgtatctgg atattcacta catggatgga tatcgggtgt tcacctttga tgagaggcga    960

tttcccgatc cggcacgcat gtgcgacgag ttgcggaagc ttggggtgcg cgttgtcccc   1020

atcgtggatc cgggggtgaa acaggatcct gaatatcccg tttacatgga cgggctagcc   1080

cacaaccact tctgccaaac cgccgagggt caagtgtatc ttggtgaggt atggcccgga   1140

ttgagtgcct ttcctgattt cgcgtcggag gaagtgcggg cgtggtgggg caagtggcat   1200

cgggtgtaca cccagatggg aattgagggc atatggaatg atatgaacga gccggctgtg   1260

ttcaatgaga cgaagaccat ggacgtgaac gtggtccacc gaggcgacgg acgattgtac   1320

acgcacggag aggtccacaa cctctatgga ttctggatgg ctgaagccac gtatcgcgga   1380

ctgaaagcgc agttggctgg caagcggcct tttgtgctca cgcgcgctgg ctacagcgga   1440

attcaacggt atgcggcggt gtggacgggc gacaaccgaa gcttttggga acatatggcc   1500

atggccatcc cgatggtgct caacatgggg atgtccggta ttccgctcgg gggcccagat   1560

gtgggcggtt tcgctcatca cgcttcaggt gaattgcttg cacgatggac gcaaatgggg   1620

gcgttctttc cgttctttcg aaatcacagt gccatgggaa cgcatcgaca ggaaccttgg   1680

gcattcggcc ctacgttcga agccgtcatt cgacgtgcca tccggctccg ttatcgtttc   1740

ctgccttatc tgtacacgct cgcacgggaa gcccatgaga caggtttacc catgatgcgg   1800

cccttggtgt tagagtatcc cgacgatcca aacacgcacc acgtcgatga tcagttcctc   1860

gtcggttccg atcttctcgt ggcacccatc ctcaagccgg gcatggccca tagaatggtc   1920

tatttgcccg atggagaatg gattgattat gagacgcgtg agcgatacca agggcgtcag   1980

tacatcttga cgtatgcgcc tctcgatcgt atccctctgt acgtgagggc agggagcgct   2040

atccccgtga acctcttgga gcggtcgggc gagacccagc taggatggga gatcttcgtg   2100

gacgccaacg gtcgagcctc gggtcgatgc tatgaggacg acggcgagac gtttagctat   2160

gaagacggcg cctactgtga tcgcgtgtta caggccctcg ccacctcgga aggaacactg   2220

atcgaatgtc atcttgttca aggatcagga gatggtggaa gtctcgagag cgttgttcgc   2280

gtgttcacac cagatgacgt tcgtgaggct cgtgcgcagg gcatatcgtt ttccatccat   2340

gtgtga                                                              2346


<210>  42
<211>  2346
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 35

<400>  42
gtgggcatga ttcacgagca gacggatttc acaaccagtg aggcgatccg cccggatacg     60

ctgatctcgc cgccagatga ctgggctttt ctcgggcgac ccagccggtt tgatgtggat    120

cacgatggct gggcgacgat tcagtatgac gctggagtca tggtcggtgt cgccgcactc    180

gacgacaccg tgctacgcgt agcctactgc aggtcccctg gggagtggcc gacgagcaca    240

cctgccattg tggaacagat gtcgcagcgg cactcctggc ggctcgttca ggaagagcga    300

cgcgtgcaac tggaatgtgt tgccggatgg cagattcaaa tcaaccggga cgacggaaca    360

tggagtatac gccatctcgg ctttgggaca gccgtcgagg ccatcacgtg gtacaagcgc    420

aaaaaaggcg gcgcattgac gtttgcttcg ctcgacaatg cccggttcta tggacttggc    480

gaaaagccgg ggccccttga caagcggcac gaggcgtaca ccatgtggaa ttcggacgtt    540

tacgcgcctc acgtgccaga gatggaggcc ctatacctgt cgatcccgtt ctttttgcga    600

ttgcaagacc aaacggccgt tggcatcttt gtggataatc cagggcgatc ccgctttgac    660

ttcaggagca gataccctga cgtggaaata tcgacagaac gaggcgggtt ggacgtttat    720

ttcatcttcg gggcttcgct caaagatgtc attcgacgtt acacaaagct cacggggcga    780

atgccgatgc cacccaagtg ggcgctcggc tatcatcagt ctcggtactc gtacgagacc    840

cagagcgagg tcctgtcggt ggcgcaaacg tttgtcgagc gcgacattcc ggtggatgcc    900

ttgtatctgg atattcacta catggatgga tatcgggtgt tcacctttga tgagaggcga    960

tttcccgatc cggcacgcat gtgcgacgag ttgcggaagc ttggggtgcg cgttgtcccc   1020

atcgtggatc cgggggtgaa acaggatcct gaatatcccg tttacatgga cgggctagcc   1080

cacaaccact tctgccaaac cgccgagggt caagtgtatc ttggtgaggt atggcccgga   1140

ttgagtgcct ttcctgattt cgcgtcggag gaagtgcggg cgtggtgggg caagtggcat   1200

cgggtgtaca cccagatggg aattgagggc atatggaatg atatgaacga gccggctgtg   1260

ttcaatgaga cgaagaccat ggacgtgaac gtggtccacc gaggcgacgg acgattgtac   1320

acgcacggag aggtccacaa cctctatgga ttctggatgg ctgaagccac gtatcgcgga   1380

ctgaaagcgc agttggctgg caagcggcct tttgtgctca cgcgcgctgg ctacagcgga   1440

attcaacggt atgcggcggt gtggacgggc gacaaccgaa gcttttggga acatatggcc   1500

atggccatcc cgatggtgct caacatgggg atgtccggta ttccgctcgg gggcccagat   1560

gtgggcggtt tcgctcatca cgcttcaggt gaattgcttg cacgatggac gcaaatgggg   1620

gcgttctttc cgttctttcg aaatcacagt gccatgggaa cgcatcgaca ggaaccttgg   1680

gcattcggcc ctacgttcga agccgtcatt cgacgtgcca tccggctccg ttatcgtttc   1740

ctgccttatc tgtacacgct cgcacgggaa gcccatgaga caggtttacc catgatgcgg   1800

cccttggtgt tagagtatcc cgacgatcca aacacgcacc acgtcgatga tcagttcctc   1860

gtcggttccg atcttctcgt ggcacccatc ctcaagccgg gcatggccca tagaatggtc   1920

tatttgcccg atggagaatg gattgattat gagacgcgtg agcgatacca agggcgtcag   1980

tacatcttga cgtatgcgcc tctcgatcgt atccctctgt acgtgagggc agggagcgct   2040

atccccgtga acctcttgga gcggtcgggc gagacccagc taggatggga gatcttcgtg   2100

gacgccaacg gtcgagcctc gggtcgatgc tatgaggacg acggcgagac gtttagctat   2160

gaagacggcg cctactgtga tcgcgtgtta caggccctcg ccacctcgga aggaacactg   2220

atcgaatgtc atcttgttca aggatcagga gatggtggaa gtctcgagag cgttgttcgc   2280

gtgttcacac cagatgacgt tcgtgaggct cgtgcgcagg gcatatcgtt ttccatccat   2340

gtgtga                                                              2346


<210>  43
<211>  2346
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 35

<400>  43
gtgggcatga ttcacgagca gacggatttc acaaccagtg aggcgatccg cccggatacg     60

ctgatctcgc cgccagatga ctgggctttt ctcgggcgac ccagccggtt tgatgtggat    120

cacgatggct gggcgacggt taactatgac gctggagtca tggtcggtgt cgccgcactc    180

gacgacaccg tgctacgcgt agcctactgc aggtcccctg gggagtggcc gacgagcaca    240

cctgccattg tggaacagat gtcgcagcgg cactcctggc ggctcgttca ggaagagcga    300

cgcgtgcaac tggaatgtgt tgccggatgg cagattcaaa tcaaccggga cgacggaaca    360

tggagtatac gccatctcgg ctttgggaca gccgtcgagg ccatcacgtg gtacaagcgc    420

aaaaaaggcg gcgcattgac gtttgcttcg ctcgacaatg cccggttcta tggacttggc    480

gaaaagccgg ggccccttga caagcggcac gaggcgtaca ccatgtggaa ttcggacgtt    540

tacgcgcctc acgtgccaga gatggaggcc ctatacctgt cgatcccgtt ctttttgcga    600

ttgcaagacc aaacggccgt tggcatcttt gtggataatc cagggcgatc ccgctttgac    660

ttcaggagca gataccctga cgtggaaata tcgacagaac gaggcgggtt ggacgtttat    720

ttcatcttcg gggcttcgct caaagatgtc attcgacgtt acacaaagct cacggggcga    780

atgccgatgc cacccaagtg ggcgctcggc tatcatcagt ctcggtactc gtacgagacc    840

cagagcgagg tcctgtcggt ggcgcaaacg tttgtcgagc gcgacattcc ggtggatgcc    900

ttgtatctgg atattcacta catggatgga tatcgggtgt tcacctttga tgagaggcga    960

tttcccgatc cggcacgcat gtgcgacgag ttgcggaagc ttggggtgcg cgttgtcccc   1020

atcgtggatc cgggggtgaa acaggatcct gaatatcccg tttacatgga cgggctagcc   1080

cacaaccact tctgccaaac cgccgagggt caagtgtatc ttggtgaggt atggcccgga   1140

ttgagtgcct ttcctgattt cgcgtcggag gaagtgcggg cgtggtgggg caagtggcat   1200

cgggtgtaca cccagatggg aattgagggc atatggaatg atatgaacga gccggctgtg   1260

ttcaatgaga cgaagaccat ggacgtgaac gtggtccacc gaggcgacgg acgattgtac   1320

acgcacggag aggtccacaa cctctatgga ttctggatgg ctgaagccac gtatcgcgga   1380

ctgaaagcgc agttggctgg caagcggcct tttgtgctca cgcgcgctgg ctacagcgga   1440

attcaacggt atgcggcggt gtggacgggc gacaaccgaa gcttttggga acatatggcc   1500

atggccatcc cgatggtgct caacatgggg atgtccggta ttccgctcgg gggcccagat   1560

gtgggcggtt tcgctcatca cgcttcaggt gaattgcttg cacgatggac gcaaatgggg   1620

gcgttctttc cgttctttcg aaatcacagt gccatgggaa cgcatcgaca ggaaccttgg   1680

gcattcggcc ctacgttcga agccgtcatt cgacgtgcca tccggctccg ttatcgtttc   1740

ctgccttatc tgtacacgct cgcacgggaa gcccatgaga caggtttacc catgatgcgg   1800

cccttggtgt tagagtatcc cgacgatcca aacacgcacc acgtcgatga tcagttcctc   1860

gtcggttccg atcttctcgt ggcacccatc ctcaagccgg gcatggccca tagaatggtc   1920

tatttgcccg atggagaatg gattgattat gagacgcgtg agcgatacca agggcgtcag   1980

tacatcttga cgtatgcgcc tctcgatcgt atccctctgt acgtgagggc agggagcgct   2040

atccccgtga acctcttgga gcggtcgggc gagacccagc taggatggga gatcttcgtg   2100

gacgccaacg gtcgagcctc gggtcgatgc tatgaggacg acggcgagac gtttagctat   2160

gaagacggcg cctactgtga tcgcgtgtta caggccctcg ccacctcgga aggaacactg   2220

atcgaatgtc atcttgttca aggatcagga gatggtggaa gtctcgagag cgttgttcgc   2280

gtgttcacac cagatgacgt tcgtgaggct cgtgcgcagg gcatatcgtt ttccatccat   2340

gtgtga                                                              2346


<210>  44
<211>  2346
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 35

<400>  44
gtgggcatga ttcacgagca gacggatttc acaaccagtg aggcgatccg cccggatacg     60

ctgatctcgc cgccagatga ctgggctttt ctcgggcgac ccagccggtt tgatgtggat    120

cacgatggct gggcgacggt tcagtatgac gctggactca tggtcggtgt cgccgcactc    180

gacgacaccg tgctacgcgt agcctactgc aggtcccctg gggagtggcc gacgagcaca    240

cctgccattg tggaacagat gtcgcagcgg cactcctggc ggctcgttca ggaagagcga    300

cgcgtgcaac tggaatgtgt tgccggatgg cagattcaaa tcaaccggga cgacggaaca    360

tggagtatac gccatctcgg ctttgggaca gccgtcgagg ccatcacgtg gtacaagcgc    420

aaaaaaggcg gcgcattgac gtttgcttcg ctcgacaatg cccggttcta tggacttggc    480

gaaaagccgg ggccccttga caagcggcac gaggcgtaca ccatgtggaa ttcggacgtt    540

tacgcgcctc acgtgccaga gatggaggcc ctatacctgt cgatcccgtt ctttttgcga    600

ttgcaagacc aaacggccgt tggcatcttt gtggataatc cagggcgatc ccgctttgac    660

ttcaggagca gataccctga cgtggaaata tcgacagaac gaggcgggtt ggacgtttat    720

ttcatcttcg gggcttcgct caaagatgtc attcgacgtt acacaaagct cacggggcga    780

atgccgatgc cacccaagtg ggcgctcggc tatcatcagt ctcggtactc gtacgagacc    840

cagagcgagg tcctgtcggt ggcgcaaacg tttgtcgagc gcgacattcc ggtggatgcc    900

ttgtatctgg atattcacta catggatgga tatcgggtgt tcacctttga tgagaggcga    960

tttcccgatc cggcacgcat gtgcgacgag ttgcggaagc ttggggtgcg cgttgtcccc   1020

atcgtggatc cgggggtgaa acaggatcct gaatatcccg tttacatgga cgggctagcc   1080

cacaaccact tctgccaaac cgccgagggt caagtgtatc ttggtgaggt atggcccgga   1140

ttgagtgcct ttcctgattt cgcgtcggag gaagtgcggg cgtggtgggg caagtggcat   1200

cgggtgtaca cccagatggg aattgagggc atatggaatg atatgaacga gccggctgtg   1260

ttcaatgaga cgaagaccat ggacgtgaac gtggtccacc gaggcgacgg acgattgtac   1320

acgcacggag aggtccacaa cctctatgga ttctggatgg ctgaagccac gtatcgcgga   1380

ctgaaagcgc agttggctgg caagcggcct tttgtgctca cgcgcgctgg ctacagcgga   1440

attcaacggt atgcggcggt gtggacgggc gacaaccgaa gcttttggga acatatggcc   1500

atggccatcc cgatggtgct caacatgggg atgtccggta ttccgctcgg gggcccagat   1560

gtgggcggtt tcgctcatca cgcttcaggt gaattgcttg cacgatggac gcaaatgggg   1620

gcgttctttc cgttctttcg aaatcacagt gccatgggaa cgcatcgaca ggaaccttgg   1680

gcattcggcc ctacgttcga agccgtcatt cgacgtgcca tccggctccg ttatcgtttc   1740

ctgccttatc tgtacacgct cgcacgggaa gcccatgaga caggtttacc catgatgcgg   1800

cccttggtgt tagagtatcc cgacgatcca aacacgcacc acgtcgatga tcagttcctc   1860

gtcggttccg atcttctcgt ggcacccatc ctcaagccgg gcatggccca tagaatggtc   1920

tatttgcccg atggagaatg gattgattat gagacgcgtg agcgatacca agggcgtcag   1980

tacatcttga cgtatgcgcc tctcgatcgt atccctctgt acgtgagggc agggagcgct   2040

atccccgtga acctcttgga gcggtcgggc gagacccagc taggatggga gatcttcgtg   2100

gacgccaacg gtcgagcctc gggtcgatgc tatgaggacg acggcgagac gtttagctat   2160

gaagacggcg cctactgtga tcgcgtgtta caggccctcg ccacctcgga aggaacactg   2220

atcgaatgtc atcttgttca aggatcagga gatggtggaa gtctcgagag cgttgttcgc   2280

gtgttcacac cagatgacgt tcgtgaggct cgtgcgcagg gcatatcgtt ttccatccat   2340

gtgtga                                                              2346


<210>  45
<211>  2346
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 35

<400>  45

Gly Thr Gly Gly Gly Cys Ala Thr Gly Ala Thr Thr Cys Ala Cys Gly 
1               5                   10                  15      


Ala Gly Cys Ala Gly Ala Cys Gly Gly Ala Thr Thr Thr Cys Ala Cys 
            20                  25                  30          


Ala Ala Cys Cys Ala Gly Thr Gly Ala Gly Gly Cys Gly Ala Thr Cys 
        35                  40                  45              


Cys Gly Cys Cys Cys Gly Gly Ala Thr Ala Cys Gly Cys Thr Gly Ala 
    50                  55                  60                  


Thr Cys Thr Cys Gly Cys Cys Gly Cys Cys Ala Gly Ala Thr Gly Ala 
65                  70                  75                  80  


Cys Thr Gly Gly Gly Cys Thr Thr Thr Thr Cys Thr Cys Gly Gly Gly 
                85                  90                  95      


Cys Gly Ala Cys Cys Cys Ala Gly Cys Cys Gly Gly Thr Thr Thr Gly 
            100                 105                 110         


Ala Thr Gly Thr Gly Gly Ala Thr Cys Ala Cys Gly Ala Thr Gly Gly 
        115                 120                 125             


Cys Thr Gly Gly Gly Cys Gly Ala Cys Gly Gly Thr Thr Cys Ala Gly 
    130                 135                 140                 


Thr Ala Thr Gly Ala Cys Gly Cys Thr Gly Gly Ala Ala Thr Cys Ala 
145                 150                 155                 160 


Thr Gly Gly Thr Cys Gly Gly Thr Gly Thr Cys Gly Cys Cys Gly Cys 
                165                 170                 175     


Ala Cys Thr Cys Gly Ala Cys Gly Ala Cys Ala Cys Cys Gly Thr Gly 
            180                 185                 190         


Cys Thr Ala Cys Gly Cys Gly Thr Ala Gly Cys Cys Thr Ala Cys Thr 
        195                 200                 205             


Gly Cys Ala Gly Gly Thr Cys Cys Cys Cys Thr Gly Gly Gly Gly Ala 
    210                 215                 220                 


Gly Thr Gly Gly Cys Cys Gly Ala Cys Gly Ala Gly Cys Ala Cys Ala 
225                 230                 235                 240 


Cys Cys Thr Gly Cys Cys Ala Thr Thr Gly Thr Gly Gly Ala Ala Cys 
                245                 250                 255     


Ala Gly Ala Thr Gly Thr Cys Gly Cys Ala Gly Cys Gly Gly Cys Ala 
            260                 265                 270         


Cys Thr Cys Cys Thr Gly Gly Cys Gly Gly Cys Thr Cys Gly Thr Thr 
        275                 280                 285             


Cys Ala Gly Gly Ala Ala Gly Ala Gly Cys Gly Ala Cys Gly Cys Gly 
    290                 295                 300                 


Thr Gly Cys Ala Ala Cys Thr Gly Gly Ala Ala Thr Gly Thr Gly Thr 
305                 310                 315                 320 


Thr Gly Cys Cys Gly Gly Ala Thr Gly Gly Cys Ala Gly Ala Thr Thr 
                325                 330                 335     


Cys Ala Ala Ala Thr Cys Ala Ala Cys Cys Gly Gly Gly Ala Cys Gly 
            340                 345                 350         


Ala Cys Gly Gly Ala Ala Cys Ala Thr Gly Gly Ala Gly Thr Ala Thr 
        355                 360                 365             


Ala Cys Gly Cys Cys Ala Thr Cys Thr Cys Gly Gly Cys Thr Thr Thr 
    370                 375                 380                 


Gly Gly Gly Ala Cys Ala Gly Cys Cys Gly Thr Cys Gly Ala Gly Gly 
385                 390                 395                 400 


Cys Cys Ala Thr Cys Ala Cys Gly Thr Gly Gly Thr Ala Cys Ala Ala 
                405                 410                 415     


Gly Cys Gly Cys Ala Ala Ala Ala Ala Ala Gly Gly Cys Gly Gly Cys 
            420                 425                 430         


Gly Cys Ala Thr Thr Gly Ala Cys Gly Thr Thr Thr Gly Cys Thr Thr 
        435                 440                 445             


Cys Gly Cys Thr Cys Gly Ala Cys Ala Ala Thr Gly Cys Cys Cys Gly 
    450                 455                 460                 


Gly Thr Thr Cys Thr Ala Thr Gly Gly Ala Cys Thr Thr Gly Gly Cys 
465                 470                 475                 480 


Gly Ala Ala Ala Ala Gly Cys Cys Gly Gly Gly Gly Cys Cys Cys Cys 
                485                 490                 495     


Thr Thr Gly Ala Cys Ala Ala Gly Cys Gly Gly Cys Ala Cys Gly Ala 
            500                 505                 510         


Gly Gly Cys Gly Thr Ala Cys Ala Cys Cys Ala Thr Gly Thr Gly Gly 
        515                 520                 525             


Ala Ala Thr Thr Cys Gly Gly Ala Cys Gly Thr Thr Thr Ala Cys Gly 
    530                 535                 540                 


Cys Gly Cys Cys Thr Cys Ala Cys Gly Thr Gly Cys Cys Ala Gly Ala 
545                 550                 555                 560 


Gly Ala Thr Gly Gly Ala Gly Gly Cys Cys Cys Thr Ala Thr Ala Cys 
                565                 570                 575     


Cys Thr Gly Thr Cys Gly Ala Thr Cys Cys Cys Gly Thr Thr Cys Thr 
            580                 585                 590         


Thr Thr Thr Thr Gly Cys Gly Ala Thr Thr Gly Cys Ala Ala Gly Ala 
        595                 600                 605             


Cys Cys Ala Ala Ala Cys Gly Gly Cys Cys Gly Thr Thr Gly Gly Cys 
    610                 615                 620                 


Ala Thr Cys Thr Thr Thr Gly Thr Gly Gly Ala Thr Ala Ala Thr Cys 
625                 630                 635                 640 


Cys Ala Gly Gly Gly Cys Gly Ala Thr Cys Cys Cys Gly Cys Thr Thr 
                645                 650                 655     


Thr Gly Ala Cys Thr Thr Cys Ala Gly Gly Ala Gly Cys Ala Gly Ala 
            660                 665                 670         


Thr Ala Cys Cys Cys Thr Gly Ala Cys Gly Thr Gly Gly Ala Ala Ala 
        675                 680                 685             


Thr Ala Thr Cys Gly Ala Cys Ala Gly Ala Ala Cys Gly Ala Gly Gly 
    690                 695                 700                 


Cys Gly Gly Gly Thr Thr Gly Gly Ala Cys Gly Thr Thr Thr Ala Thr 
705                 710                 715                 720 


Thr Thr Cys Ala Thr Cys Thr Thr Cys Gly Gly Gly Gly Cys Thr Thr 
                725                 730                 735     


Cys Gly Cys Thr Cys Ala Ala Ala Gly Ala Thr Gly Thr Cys Ala Thr 
            740                 745                 750         


Thr Cys Gly Ala Cys Gly Thr Thr Ala Cys Ala Cys Ala Ala Ala Gly 
        755                 760                 765             


Cys Thr Cys Ala Cys Gly Gly Gly Gly Cys Gly Ala Ala Thr Gly Cys 
    770                 775                 780                 


Cys Gly Ala Thr Gly Cys Cys Ala Cys Cys Cys Ala Ala Gly Thr Gly 
785                 790                 795                 800 


Gly Gly Cys Gly Cys Thr Cys Gly Gly Cys Thr Ala Thr Cys Ala Thr 
                805                 810                 815     


Cys Ala Gly Thr Cys Thr Cys Gly Gly Thr Ala Cys Thr Cys Gly Thr 
            820                 825                 830         


Ala Cys Gly Ala Gly Ala Cys Cys Cys Ala Gly Ala Gly Cys Gly Ala 
        835                 840                 845             


Gly Gly Thr Cys Cys Thr Gly Thr Cys Gly Gly Thr Gly Gly Cys Gly 
    850                 855                 860                 


Cys Ala Ala Ala Cys Gly Thr Thr Thr Gly Thr Cys Gly Ala Gly Cys 
865                 870                 875                 880 


Gly Cys Gly Ala Cys Ala Thr Thr Cys Cys Gly Gly Thr Gly Gly Ala 
                885                 890                 895     


Thr Gly Cys Cys Thr Thr Gly Thr Ala Thr Cys Thr Gly Gly Ala Thr 
            900                 905                 910         


Ala Thr Thr Cys Ala Cys Thr Ala Cys Ala Thr Gly Gly Ala Thr Gly 
        915                 920                 925             


Gly Ala Thr Ala Thr Cys Gly Gly Gly Thr Gly Thr Thr Cys Ala Cys 
    930                 935                 940                 


Cys Thr Thr Thr Gly Ala Thr Gly Ala Gly Ala Gly Gly Cys Gly Ala 
945                 950                 955                 960 


Thr Thr Thr Cys Cys Cys Gly Ala Thr Cys Cys Gly Gly Cys Ala Cys 
                965                 970                 975     


Gly Cys Ala Thr Gly Thr Gly Cys Gly Ala Cys Gly Ala Gly Thr Thr 
            980                 985                 990         


Gly Cys Gly Gly Ala Ala Gly Cys  Thr Thr Gly Gly Gly  Gly Thr Gly 
        995                 1000                 1005             


Cys Gly  Cys Gly Thr Thr Gly  Thr Cys Cys Cys Cys  Ala Thr Cys 
    1010                 1015                 1020             


Gly Thr  Gly Gly Ala Thr Cys  Cys Gly Gly Gly Gly  Gly Thr Gly 
    1025                 1030                 1035             


Ala Ala  Ala Cys Ala Gly Gly  Ala Thr Cys Cys Thr  Gly Ala Ala 
    1040                 1045                 1050             


Thr Ala  Thr Cys Cys Cys Gly  Thr Thr Thr Ala Cys  Ala Thr Gly 
    1055                 1060                 1065             


Gly Ala  Cys Gly Gly Gly Cys  Thr Ala Gly Cys Cys  Cys Ala Cys 
    1070                 1075                 1080             


Ala Ala  Cys Cys Ala Cys Thr  Thr Cys Thr Gly Cys  Cys Ala Ala 
    1085                 1090                 1095             


Ala Cys  Cys Gly Cys Cys Gly  Ala Gly Gly Gly Thr  Cys Ala Ala 
    1100                 1105                 1110             


Gly Thr  Gly Thr Ala Thr Cys  Thr Thr Gly Gly Thr  Gly Ala Gly 
    1115                 1120                 1125             


Gly Thr  Ala Thr Gly Gly Cys  Cys Cys Gly Gly Ala  Thr Thr Gly 
    1130                 1135                 1140             


Ala Gly  Thr Gly Cys Cys Thr  Thr Thr Cys Cys Thr  Gly Ala Thr 
    1145                 1150                 1155             


Thr Thr  Cys Gly Cys Gly Thr  Cys Gly Gly Ala Gly  Gly Ala Ala 
    1160                 1165                 1170             


Gly Thr  Gly Cys Gly Gly Gly  Cys Gly Thr Gly Gly  Thr Gly Gly 
    1175                 1180                 1185             


Gly Gly  Cys Ala Ala Gly Thr  Gly Gly Cys Ala Thr  Cys Gly Gly 
    1190                 1195                 1200             


Gly Thr  Gly Thr Ala Cys Ala  Cys Cys Cys Ala Gly  Ala Thr Gly 
    1205                 1210                 1215             


Gly Gly  Ala Ala Thr Thr Gly  Ala Gly Gly Gly Cys  Ala Thr Ala 
    1220                 1225                 1230             


Thr Gly  Gly Ala Ala Thr Gly  Ala Thr Ala Thr Gly  Ala Ala Cys 
    1235                 1240                 1245             


Gly Ala  Gly Cys Cys Gly Gly  Cys Thr Gly Thr Gly  Thr Thr Cys 
    1250                 1255                 1260             


Ala Ala  Thr Gly Ala Gly Ala  Cys Gly Ala Ala Gly  Ala Cys Cys 
    1265                 1270                 1275             


Ala Thr  Gly Gly Ala Cys Gly  Thr Gly Ala Ala Cys  Gly Thr Gly 
    1280                 1285                 1290             


Gly Thr  Cys Cys Ala Cys Cys  Gly Ala Gly Gly Cys  Gly Ala Cys 
    1295                 1300                 1305             


Gly Gly  Ala Cys Gly Ala Thr  Thr Gly Thr Ala Cys  Ala Cys Gly 
    1310                 1315                 1320             


Cys Ala  Cys Gly Gly Ala Gly  Ala Gly Gly Thr Cys  Cys Ala Cys 
    1325                 1330                 1335             


Ala Ala  Cys Cys Thr Cys Thr  Ala Thr Gly Gly Ala  Thr Thr Cys 
    1340                 1345                 1350             


Thr Gly  Gly Ala Thr Gly Gly  Cys Thr Gly Ala Ala  Gly Cys Cys 
    1355                 1360                 1365             


Ala Cys  Gly Thr Ala Thr Cys  Gly Cys Gly Gly Ala  Cys Thr Gly 
    1370                 1375                 1380             


Ala Ala  Ala Gly Cys Gly Cys  Ala Gly Thr Thr Gly  Gly Cys Thr 
    1385                 1390                 1395             


Gly Gly  Cys Ala Ala Gly Cys  Gly Gly Cys Cys Thr  Thr Thr Thr 
    1400                 1405                 1410             


Gly Thr  Gly Cys Thr Cys Ala  Cys Gly Cys Gly Cys  Gly Cys Thr 
    1415                 1420                 1425             


Gly Gly  Cys Thr Ala Cys Ala  Gly Cys Gly Gly Ala  Ala Thr Thr 
    1430                 1435                 1440             


Cys Ala  Ala Cys Gly Gly Thr  Ala Thr Gly Cys Gly  Gly Cys Gly 
    1445                 1450                 1455             


Gly Thr  Gly Thr Gly Gly Ala  Cys Gly Gly Gly Cys  Gly Ala Cys 
    1460                 1465                 1470             


Ala Ala  Cys Cys Gly Ala Ala  Gly Cys Thr Thr Thr  Thr Gly Gly 
    1475                 1480                 1485             


Gly Ala  Ala Cys Ala Thr Ala  Thr Gly Gly Cys Cys  Ala Thr Gly 
    1490                 1495                 1500             


Gly Cys  Cys Ala Thr Cys Cys  Cys Gly Ala Thr Gly  Gly Thr Gly 
    1505                 1510                 1515             


Cys Thr  Cys Ala Ala Cys Ala  Thr Gly Gly Gly Gly  Ala Thr Gly 
    1520                 1525                 1530             


Thr Cys  Cys Gly Gly Thr Ala  Thr Thr Cys Cys Gly  Cys Thr Cys 
    1535                 1540                 1545             


Gly Gly  Gly Gly Gly Cys Cys  Cys Ala Gly Ala Thr  Gly Thr Gly 
    1550                 1555                 1560             


Gly Gly  Cys Gly Gly Thr Thr  Thr Cys Gly Cys Thr  Cys Ala Thr 
    1565                 1570                 1575             


Cys Ala  Cys Gly Cys Thr Thr  Cys Ala Gly Gly Thr  Gly Ala Ala 
    1580                 1585                 1590             


Thr Thr  Gly Cys Thr Thr Gly  Cys Ala Cys Gly Ala  Thr Gly Gly 
    1595                 1600                 1605             


Ala Cys  Gly Cys Ala Ala Ala  Thr Gly Gly Gly Gly  Gly Cys Gly 
    1610                 1615                 1620             


Thr Thr  Cys Thr Thr Thr Cys  Cys Gly Thr Thr Cys  Thr Thr Thr 
    1625                 1630                 1635             


Cys Gly  Ala Ala Ala Thr Cys  Ala Cys Ala Gly Thr  Gly Cys Cys 
    1640                 1645                 1650             


Ala Thr  Gly Gly Gly Ala Ala  Cys Gly Cys Ala Thr  Cys Gly Ala 
    1655                 1660                 1665             


Cys Ala  Gly Gly Ala Ala Cys  Cys Thr Thr Gly Gly  Gly Cys Ala 
    1670                 1675                 1680             


Thr Thr  Cys Gly Gly Cys Cys  Cys Thr Ala Cys Gly  Thr Thr Cys 
    1685                 1690                 1695             


Gly Ala  Ala Gly Cys Cys Gly  Thr Cys Ala Thr Thr  Cys Gly Ala 
    1700                 1705                 1710             


Cys Gly  Thr Gly Cys Cys Ala  Thr Cys Cys Gly Gly  Cys Thr Cys 
    1715                 1720                 1725             


Cys Gly  Thr Thr Ala Thr Cys  Gly Thr Thr Thr Cys  Cys Thr Gly 
    1730                 1735                 1740             


Cys Cys  Thr Thr Ala Thr Cys  Thr Gly Thr Ala Cys  Ala Cys Gly 
    1745                 1750                 1755             


Cys Thr  Cys Gly Cys Ala Cys  Gly Gly Gly Ala Ala  Gly Cys Cys 
    1760                 1765                 1770             


Cys Ala  Thr Gly Ala Gly Ala  Cys Ala Gly Gly Thr  Thr Thr Ala 
    1775                 1780                 1785             


Cys Cys  Cys Ala Thr Gly Ala  Thr Gly Cys Gly Gly  Cys Cys Cys 
    1790                 1795                 1800             


Thr Thr  Gly Gly Thr Gly Thr  Thr Ala Gly Ala Gly  Thr Ala Thr 
    1805                 1810                 1815             


Cys Cys  Cys Gly Ala Cys Gly  Ala Thr Cys Cys Ala  Ala Ala Cys 
    1820                 1825                 1830             


Ala Cys  Gly Cys Ala Cys Cys  Ala Cys Gly Thr Cys  Gly Ala Thr 
    1835                 1840                 1845             


Gly Ala  Thr Cys Ala Gly Thr  Thr Cys Cys Thr Cys  Gly Thr Cys 
    1850                 1855                 1860             


Gly Gly  Thr Thr Cys Cys Gly  Ala Thr Cys Thr Thr  Cys Thr Cys 
    1865                 1870                 1875             


Gly Thr  Gly Gly Cys Ala Cys  Cys Cys Ala Thr Cys  Cys Thr Cys 
    1880                 1885                 1890             


Ala Ala  Gly Cys Cys Gly Gly  Gly Cys Ala Thr Gly  Gly Cys Cys 
    1895                 1900                 1905             


Cys Ala  Thr Ala Gly Ala Ala  Thr Gly Gly Thr Cys  Thr Ala Thr 
    1910                 1915                 1920             


Thr Thr  Gly Cys Cys Cys Gly  Ala Thr Gly Gly Ala  Gly Ala Ala 
    1925                 1930                 1935             


Thr Gly  Gly Ala Thr Thr Gly  Ala Thr Thr Ala Thr  Gly Ala Gly 
    1940                 1945                 1950             


Ala Cys  Gly Cys Gly Thr Gly  Ala Gly Cys Gly Ala  Thr Ala Cys 
    1955                 1960                 1965             


Cys Ala  Ala Gly Gly Gly Cys  Gly Thr Cys Ala Gly  Thr Ala Cys 
    1970                 1975                 1980             


Ala Thr  Cys Thr Thr Gly Ala  Cys Gly Thr Ala Thr  Gly Cys Gly 
    1985                 1990                 1995             


Cys Cys  Thr Cys Thr Cys Gly  Ala Thr Cys Gly Thr  Ala Thr Cys 
    2000                 2005                 2010             


Cys Cys  Thr Cys Thr Gly Thr  Ala Cys Gly Thr Gly  Ala Gly Gly 
    2015                 2020                 2025             


Gly Cys  Ala Gly Gly Gly Ala  Gly Cys Gly Cys Thr  Ala Thr Cys 
    2030                 2035                 2040             


Cys Cys  Cys Gly Thr Gly Ala  Ala Cys Cys Thr Cys  Thr Thr Gly 
    2045                 2050                 2055             


Gly Ala  Gly Cys Gly Gly Thr  Cys Gly Gly Gly Cys  Gly Ala Gly 
    2060                 2065                 2070             


Ala Cys  Cys Cys Ala Gly Cys  Thr Ala Gly Gly Ala  Thr Gly Gly 
    2075                 2080                 2085             


Gly Ala  Gly Ala Thr Cys Thr  Thr Cys Gly Thr Gly  Gly Ala Cys 
    2090                 2095                 2100             


Gly Cys  Cys Ala Ala Cys Gly  Gly Thr Cys Gly Ala  Gly Cys Cys 
    2105                 2110                 2115             


Thr Cys  Gly Gly Gly Thr Cys  Gly Ala Thr Gly Cys  Thr Ala Thr 
    2120                 2125                 2130             


Gly Ala  Gly Gly Ala Cys Gly  Ala Cys Gly Gly Cys  Gly Ala Gly 
    2135                 2140                 2145             


Ala Cys  Gly Thr Thr Thr Ala  Gly Cys Thr Ala Thr  Gly Ala Ala 
    2150                 2155                 2160             


Gly Ala  Cys Gly Gly Cys Gly  Cys Cys Thr Ala Cys  Thr Gly Thr 
    2165                 2170                 2175             


Gly Ala  Thr Cys Gly Cys Gly  Thr Gly Thr Thr Ala  Cys Ala Gly 
    2180                 2185                 2190             


Gly Cys  Cys Cys Thr Cys Gly  Cys Cys Ala Cys Cys  Thr Cys Gly 
    2195                 2200                 2205             


Gly Ala  Ala Gly Gly Ala Ala  Cys Ala Cys Thr Gly  Ala Thr Cys 
    2210                 2215                 2220             


Gly Ala  Ala Thr Gly Thr Cys  Ala Thr Cys Thr Thr  Gly Thr Thr 
    2225                 2230                 2235             


Cys Ala  Ala Gly Gly Ala Thr  Cys Ala Gly Gly Ala  Gly Ala Thr 
    2240                 2245                 2250             


Gly Gly  Thr Gly Gly Ala Ala  Gly Thr Cys Thr Cys  Gly Ala Gly 
    2255                 2260                 2265             


Ala Gly  Cys Gly Thr Thr Gly  Thr Thr Cys Gly Cys  Gly Thr Gly 
    2270                 2275                 2280             


Thr Thr  Cys Ala Cys Ala Cys  Cys Ala Gly Ala Thr  Gly Ala Cys 
    2285                 2290                 2295             


Gly Thr  Thr Cys Gly Thr Gly  Ala Gly Gly Cys Thr  Cys Gly Thr 
    2300                 2305                 2310             


Gly Cys  Gly Cys Ala Gly Gly  Gly Cys Ala Thr Ala  Thr Cys Gly 
    2315                 2320                 2325             


Thr Thr  Thr Thr Cys Cys Ala  Thr Cys Cys Ala Thr  Gly Thr Gly 
    2330                 2335                 2340             


Thr Gly  Ala 
    2345     


<210>  46
<211>  781
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:36 and encoded by SEQ ID NO:41

<400>  46

Met Gly Met Ile His Glu Gln Thr Asp Phe Thr Thr Ser Glu Ala Ile 
1               5                   10                  15      


Arg Pro Asp Thr Leu Ile Ser Pro Pro Asp Asp Trp Ala Phe Leu Gly 
            20                  25                  30          


Arg Pro Ser Arg Phe Asp Val Asp His Asp Gly Trp Ala Thr Leu Gln 
        35                  40                  45              


Tyr Asp Ala Gly Val Met Val Gly Val Ala Ala Leu Asp Asp Thr Val 
    50                  55                  60                  


Leu Arg Val Ala Tyr Cys Arg Ser Pro Gly Glu Trp Pro Thr Ser Thr 
65                  70                  75                  80  


Pro Ala Ile Val Glu Gln Met Ser Gln Arg His Ser Trp Arg Leu Val 
                85                  90                  95      


Gln Glu Glu Arg Arg Val Gln Leu Glu Cys Val Ala Gly Trp Gln Ile 
            100                 105                 110         


Gln Ile Asn Arg Asp Asp Gly Thr Trp Ser Ile Arg His Leu Gly Phe 
        115                 120                 125             


Gly Thr Ala Val Glu Ala Ile Thr Trp Tyr Lys Arg Lys Lys Gly Gly 
    130                 135                 140                 


Ala Leu Thr Phe Ala Ser Leu Asp Asn Ala Arg Phe Tyr Gly Leu Gly 
145                 150                 155                 160 


Glu Lys Pro Gly Pro Leu Asp Lys Arg His Glu Ala Tyr Thr Met Trp 
                165                 170                 175     


Asn Ser Asp Val Tyr Ala Pro His Val Pro Glu Met Glu Ala Leu Tyr 
            180                 185                 190         


Leu Ser Ile Pro Phe Phe Leu Arg Leu Gln Asp Gln Thr Ala Val Gly 
        195                 200                 205             


Ile Phe Val Asp Asn Pro Gly Arg Ser Arg Phe Asp Phe Arg Ser Arg 
    210                 215                 220                 


Tyr Pro Asp Val Glu Ile Ser Thr Glu Arg Gly Gly Leu Asp Val Tyr 
225                 230                 235                 240 


Phe Ile Phe Gly Ala Ser Leu Lys Asp Val Ile Arg Arg Tyr Thr Lys 
                245                 250                 255     


Leu Thr Gly Arg Met Pro Met Pro Pro Lys Trp Ala Leu Gly Tyr His 
            260                 265                 270         


Gln Ser Arg Tyr Ser Tyr Glu Thr Gln Ser Glu Val Leu Ser Val Ala 
        275                 280                 285             


Gln Thr Phe Val Glu Arg Asp Ile Pro Val Asp Ala Leu Tyr Leu Asp 
    290                 295                 300                 


Ile His Tyr Met Asp Gly Tyr Arg Val Phe Thr Phe Asp Glu Arg Arg 
305                 310                 315                 320 


Phe Pro Asp Pro Ala Arg Met Cys Asp Glu Leu Arg Lys Leu Gly Val 
                325                 330                 335     


Arg Val Val Pro Ile Val Asp Pro Gly Val Lys Gln Asp Pro Glu Tyr 
            340                 345                 350         


Pro Val Tyr Met Asp Gly Leu Ala His Asn His Phe Cys Gln Thr Ala 
        355                 360                 365             


Glu Gly Gln Val Tyr Leu Gly Glu Val Trp Pro Gly Leu Ser Ala Phe 
    370                 375                 380                 


Pro Asp Phe Ala Ser Glu Glu Val Arg Ala Trp Trp Gly Lys Trp His 
385                 390                 395                 400 


Arg Val Tyr Thr Gln Met Gly Ile Glu Gly Ile Trp Asn Asp Met Asn 
                405                 410                 415     


Glu Pro Ala Val Phe Asn Glu Thr Lys Thr Met Asp Val Asn Val Val 
            420                 425                 430         


His Arg Gly Asp Gly Arg Leu Tyr Thr His Gly Glu Val His Asn Leu 
        435                 440                 445             


Tyr Gly Phe Trp Met Ala Glu Ala Thr Tyr Arg Gly Leu Lys Ala Gln 
    450                 455                 460                 


Leu Ala Gly Lys Arg Pro Phe Val Leu Thr Arg Ala Gly Tyr Ser Gly 
465                 470                 475                 480 


Ile Gln Arg Tyr Ala Ala Val Trp Thr Gly Asp Asn Arg Ser Phe Trp 
                485                 490                 495     


Glu His Met Ala Met Ala Ile Pro Met Val Leu Asn Met Gly Met Ser 
            500                 505                 510         


Gly Ile Pro Leu Gly Gly Pro Asp Val Gly Gly Phe Ala His His Ala 
        515                 520                 525             


Ser Gly Glu Leu Leu Ala Arg Trp Thr Gln Met Gly Ala Phe Phe Pro 
    530                 535                 540                 


Phe Phe Arg Asn His Ser Ala Met Gly Thr His Arg Gln Glu Pro Trp 
545                 550                 555                 560 


Ala Phe Gly Pro Thr Phe Glu Ala Val Ile Arg Arg Ala Ile Arg Leu 
                565                 570                 575     


Arg Tyr Arg Phe Leu Pro Tyr Leu Tyr Thr Leu Ala Arg Glu Ala His 
            580                 585                 590         


Glu Thr Gly Leu Pro Met Met Arg Pro Leu Val Leu Glu Tyr Pro Asp 
        595                 600                 605             


Asp Pro Asn Thr His His Val Asp Asp Gln Phe Leu Val Gly Ser Asp 
    610                 615                 620                 


Leu Leu Val Ala Pro Ile Leu Lys Pro Gly Met Ala His Arg Met Val 
625                 630                 635                 640 


Tyr Leu Pro Asp Gly Glu Trp Ile Asp Tyr Glu Thr Arg Glu Arg Tyr 
                645                 650                 655     


Gln Gly Arg Gln Tyr Ile Leu Thr Tyr Ala Pro Leu Asp Arg Ile Pro 
            660                 665                 670         


Leu Tyr Val Arg Ala Gly Ser Ala Ile Pro Val Asn Leu Leu Glu Arg 
        675                 680                 685             


Ser Gly Glu Thr Gln Leu Gly Trp Glu Ile Phe Val Asp Ala Asn Gly 
    690                 695                 700                 


Arg Ala Ser Gly Arg Cys Tyr Glu Asp Asp Gly Glu Thr Phe Ser Tyr 
705                 710                 715                 720 


Glu Asp Gly Ala Tyr Cys Asp Arg Val Leu Gln Ala Leu Ala Thr Ser 
                725                 730                 735     


Glu Gly Thr Leu Ile Glu Cys His Leu Val Gln Gly Ser Gly Asp Gly 
            740                 745                 750         


Gly Ser Leu Glu Ser Val Val Arg Val Phe Thr Pro Asp Asp Val Arg 
        755                 760                 765             


Glu Ala Arg Ala Gln Gly Ile Ser Phe Ser Ile His Val 
    770                 775                 780     


<210>  47
<211>  781
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:36 and encoded by SEQ ID NO:42

<400>  47

Met Gly Met Ile His Glu Gln Thr Asp Phe Thr Thr Ser Glu Ala Ile 
1               5                   10                  15      


Arg Pro Asp Thr Leu Ile Ser Pro Pro Asp Asp Trp Ala Phe Leu Gly 
            20                  25                  30          


Arg Pro Ser Arg Phe Asp Val Asp His Asp Gly Trp Ala Thr Ile Gln 
        35                  40                  45              


Tyr Asp Ala Gly Val Met Val Gly Val Ala Ala Leu Asp Asp Thr Val 
    50                  55                  60                  


Leu Arg Val Ala Tyr Cys Arg Ser Pro Gly Glu Trp Pro Thr Ser Thr 
65                  70                  75                  80  


Pro Ala Ile Val Glu Gln Met Ser Gln Arg His Ser Trp Arg Leu Val 
                85                  90                  95      


Gln Glu Glu Arg Arg Val Gln Leu Glu Cys Val Ala Gly Trp Gln Ile 
            100                 105                 110         


Gln Ile Asn Arg Asp Asp Gly Thr Trp Ser Ile Arg His Leu Gly Phe 
        115                 120                 125             


Gly Thr Ala Val Glu Ala Ile Thr Trp Tyr Lys Arg Lys Lys Gly Gly 
    130                 135                 140                 


Ala Leu Thr Phe Ala Ser Leu Asp Asn Ala Arg Phe Tyr Gly Leu Gly 
145                 150                 155                 160 


Glu Lys Pro Gly Pro Leu Asp Lys Arg His Glu Ala Tyr Thr Met Trp 
                165                 170                 175     


Asn Ser Asp Val Tyr Ala Pro His Val Pro Glu Met Glu Ala Leu Tyr 
            180                 185                 190         


Leu Ser Ile Pro Phe Phe Leu Arg Leu Gln Asp Gln Thr Ala Val Gly 
        195                 200                 205             


Ile Phe Val Asp Asn Pro Gly Arg Ser Arg Phe Asp Phe Arg Ser Arg 
    210                 215                 220                 


Tyr Pro Asp Val Glu Ile Ser Thr Glu Arg Gly Gly Leu Asp Val Tyr 
225                 230                 235                 240 


Phe Ile Phe Gly Ala Ser Leu Lys Asp Val Ile Arg Arg Tyr Thr Lys 
                245                 250                 255     


Leu Thr Gly Arg Met Pro Met Pro Pro Lys Trp Ala Leu Gly Tyr His 
            260                 265                 270         


Gln Ser Arg Tyr Ser Tyr Glu Thr Gln Ser Glu Val Leu Ser Val Ala 
        275                 280                 285             


Gln Thr Phe Val Glu Arg Asp Ile Pro Val Asp Ala Leu Tyr Leu Asp 
    290                 295                 300                 


Ile His Tyr Met Asp Gly Tyr Arg Val Phe Thr Phe Asp Glu Arg Arg 
305                 310                 315                 320 


Phe Pro Asp Pro Ala Arg Met Cys Asp Glu Leu Arg Lys Leu Gly Val 
                325                 330                 335     


Arg Val Val Pro Ile Val Asp Pro Gly Val Lys Gln Asp Pro Glu Tyr 
            340                 345                 350         


Pro Val Tyr Met Asp Gly Leu Ala His Asn His Phe Cys Gln Thr Ala 
        355                 360                 365             


Glu Gly Gln Val Tyr Leu Gly Glu Val Trp Pro Gly Leu Ser Ala Phe 
    370                 375                 380                 


Pro Asp Phe Ala Ser Glu Glu Val Arg Ala Trp Trp Gly Lys Trp His 
385                 390                 395                 400 


Arg Val Tyr Thr Gln Met Gly Ile Glu Gly Ile Trp Asn Asp Met Asn 
                405                 410                 415     


Glu Pro Ala Val Phe Asn Glu Thr Lys Thr Met Asp Val Asn Val Val 
            420                 425                 430         


His Arg Gly Asp Gly Arg Leu Tyr Thr His Gly Glu Val His Asn Leu 
        435                 440                 445             


Tyr Gly Phe Trp Met Ala Glu Ala Thr Tyr Arg Gly Leu Lys Ala Gln 
    450                 455                 460                 


Leu Ala Gly Lys Arg Pro Phe Val Leu Thr Arg Ala Gly Tyr Ser Gly 
465                 470                 475                 480 


Ile Gln Arg Tyr Ala Ala Val Trp Thr Gly Asp Asn Arg Ser Phe Trp 
                485                 490                 495     


Glu His Met Ala Met Ala Ile Pro Met Val Leu Asn Met Gly Met Ser 
            500                 505                 510         


Gly Ile Pro Leu Gly Gly Pro Asp Val Gly Gly Phe Ala His His Ala 
        515                 520                 525             


Ser Gly Glu Leu Leu Ala Arg Trp Thr Gln Met Gly Ala Phe Phe Pro 
    530                 535                 540                 


Phe Phe Arg Asn His Ser Ala Met Gly Thr His Arg Gln Glu Pro Trp 
545                 550                 555                 560 


Ala Phe Gly Pro Thr Phe Glu Ala Val Ile Arg Arg Ala Ile Arg Leu 
                565                 570                 575     


Arg Tyr Arg Phe Leu Pro Tyr Leu Tyr Thr Leu Ala Arg Glu Ala His 
            580                 585                 590         


Glu Thr Gly Leu Pro Met Met Arg Pro Leu Val Leu Glu Tyr Pro Asp 
        595                 600                 605             


Asp Pro Asn Thr His His Val Asp Asp Gln Phe Leu Val Gly Ser Asp 
    610                 615                 620                 


Leu Leu Val Ala Pro Ile Leu Lys Pro Gly Met Ala His Arg Met Val 
625                 630                 635                 640 


Tyr Leu Pro Asp Gly Glu Trp Ile Asp Tyr Glu Thr Arg Glu Arg Tyr 
                645                 650                 655     


Gln Gly Arg Gln Tyr Ile Leu Thr Tyr Ala Pro Leu Asp Arg Ile Pro 
            660                 665                 670         


Leu Tyr Val Arg Ala Gly Ser Ala Ile Pro Val Asn Leu Leu Glu Arg 
        675                 680                 685             


Ser Gly Glu Thr Gln Leu Gly Trp Glu Ile Phe Val Asp Ala Asn Gly 
    690                 695                 700                 


Arg Ala Ser Gly Arg Cys Tyr Glu Asp Asp Gly Glu Thr Phe Ser Tyr 
705                 710                 715                 720 


Glu Asp Gly Ala Tyr Cys Asp Arg Val Leu Gln Ala Leu Ala Thr Ser 
                725                 730                 735     


Glu Gly Thr Leu Ile Glu Cys His Leu Val Gln Gly Ser Gly Asp Gly 
            740                 745                 750         


Gly Ser Leu Glu Ser Val Val Arg Val Phe Thr Pro Asp Asp Val Arg 
        755                 760                 765             


Glu Ala Arg Ala Gln Gly Ile Ser Phe Ser Ile His Val 
    770                 775                 780     


<210>  48
<211>  781
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:36 and encoded by SEQ ID NO:43

<400>  48

Met Gly Met Ile His Glu Gln Thr Asp Phe Thr Thr Ser Glu Ala Ile 
1               5                   10                  15      


Arg Pro Asp Thr Leu Ile Ser Pro Pro Asp Asp Trp Ala Phe Leu Gly 
            20                  25                  30          


Arg Pro Ser Arg Phe Asp Val Asp His Asp Gly Trp Ala Thr Val Asn 
        35                  40                  45              


Tyr Asp Ala Gly Val Met Val Gly Val Ala Ala Leu Asp Asp Thr Val 
    50                  55                  60                  


Leu Arg Val Ala Tyr Cys Arg Ser Pro Gly Glu Trp Pro Thr Ser Thr 
65                  70                  75                  80  


Pro Ala Ile Val Glu Gln Met Ser Gln Arg His Ser Trp Arg Leu Val 
                85                  90                  95      


Gln Glu Glu Arg Arg Val Gln Leu Glu Cys Val Ala Gly Trp Gln Ile 
            100                 105                 110         


Gln Ile Asn Arg Asp Asp Gly Thr Trp Ser Ile Arg His Leu Gly Phe 
        115                 120                 125             


Gly Thr Ala Val Glu Ala Ile Thr Trp Tyr Lys Arg Lys Lys Gly Gly 
    130                 135                 140                 


Ala Leu Thr Phe Ala Ser Leu Asp Asn Ala Arg Phe Tyr Gly Leu Gly 
145                 150                 155                 160 


Glu Lys Pro Gly Pro Leu Asp Lys Arg His Glu Ala Tyr Thr Met Trp 
                165                 170                 175     


Asn Ser Asp Val Tyr Ala Pro His Val Pro Glu Met Glu Ala Leu Tyr 
            180                 185                 190         


Leu Ser Ile Pro Phe Phe Leu Arg Leu Gln Asp Gln Thr Ala Val Gly 
        195                 200                 205             


Ile Phe Val Asp Asn Pro Gly Arg Ser Arg Phe Asp Phe Arg Ser Arg 
    210                 215                 220                 


Tyr Pro Asp Val Glu Ile Ser Thr Glu Arg Gly Gly Leu Asp Val Tyr 
225                 230                 235                 240 


Phe Ile Phe Gly Ala Ser Leu Lys Asp Val Ile Arg Arg Tyr Thr Lys 
                245                 250                 255     


Leu Thr Gly Arg Met Pro Met Pro Pro Lys Trp Ala Leu Gly Tyr His 
            260                 265                 270         


Gln Ser Arg Tyr Ser Tyr Glu Thr Gln Ser Glu Val Leu Ser Val Ala 
        275                 280                 285             


Gln Thr Phe Val Glu Arg Asp Ile Pro Val Asp Ala Leu Tyr Leu Asp 
    290                 295                 300                 


Ile His Tyr Met Asp Gly Tyr Arg Val Phe Thr Phe Asp Glu Arg Arg 
305                 310                 315                 320 


Phe Pro Asp Pro Ala Arg Met Cys Asp Glu Leu Arg Lys Leu Gly Val 
                325                 330                 335     


Arg Val Val Pro Ile Val Asp Pro Gly Val Lys Gln Asp Pro Glu Tyr 
            340                 345                 350         


Pro Val Tyr Met Asp Gly Leu Ala His Asn His Phe Cys Gln Thr Ala 
        355                 360                 365             


Glu Gly Gln Val Tyr Leu Gly Glu Val Trp Pro Gly Leu Ser Ala Phe 
    370                 375                 380                 


Pro Asp Phe Ala Ser Glu Glu Val Arg Ala Trp Trp Gly Lys Trp His 
385                 390                 395                 400 


Arg Val Tyr Thr Gln Met Gly Ile Glu Gly Ile Trp Asn Asp Met Asn 
                405                 410                 415     


Glu Pro Ala Val Phe Asn Glu Thr Lys Thr Met Asp Val Asn Val Val 
            420                 425                 430         


His Arg Gly Asp Gly Arg Leu Tyr Thr His Gly Glu Val His Asn Leu 
        435                 440                 445             


Tyr Gly Phe Trp Met Ala Glu Ala Thr Tyr Arg Gly Leu Lys Ala Gln 
    450                 455                 460                 


Leu Ala Gly Lys Arg Pro Phe Val Leu Thr Arg Ala Gly Tyr Ser Gly 
465                 470                 475                 480 


Ile Gln Arg Tyr Ala Ala Val Trp Thr Gly Asp Asn Arg Ser Phe Trp 
                485                 490                 495     


Glu His Met Ala Met Ala Ile Pro Met Val Leu Asn Met Gly Met Ser 
            500                 505                 510         


Gly Ile Pro Leu Gly Gly Pro Asp Val Gly Gly Phe Ala His His Ala 
        515                 520                 525             


Ser Gly Glu Leu Leu Ala Arg Trp Thr Gln Met Gly Ala Phe Phe Pro 
    530                 535                 540                 


Phe Phe Arg Asn His Ser Ala Met Gly Thr His Arg Gln Glu Pro Trp 
545                 550                 555                 560 


Ala Phe Gly Pro Thr Phe Glu Ala Val Ile Arg Arg Ala Ile Arg Leu 
                565                 570                 575     


Arg Tyr Arg Phe Leu Pro Tyr Leu Tyr Thr Leu Ala Arg Glu Ala His 
            580                 585                 590         


Glu Thr Gly Leu Pro Met Met Arg Pro Leu Val Leu Glu Tyr Pro Asp 
        595                 600                 605             


Asp Pro Asn Thr His His Val Asp Asp Gln Phe Leu Val Gly Ser Asp 
    610                 615                 620                 


Leu Leu Val Ala Pro Ile Leu Lys Pro Gly Met Ala His Arg Met Val 
625                 630                 635                 640 


Tyr Leu Pro Asp Gly Glu Trp Ile Asp Tyr Glu Thr Arg Glu Arg Tyr 
                645                 650                 655     


Gln Gly Arg Gln Tyr Ile Leu Thr Tyr Ala Pro Leu Asp Arg Ile Pro 
            660                 665                 670         


Leu Tyr Val Arg Ala Gly Ser Ala Ile Pro Val Asn Leu Leu Glu Arg 
        675                 680                 685             


Ser Gly Glu Thr Gln Leu Gly Trp Glu Ile Phe Val Asp Ala Asn Gly 
    690                 695                 700                 


Arg Ala Ser Gly Arg Cys Tyr Glu Asp Asp Gly Glu Thr Phe Ser Tyr 
705                 710                 715                 720 


Glu Asp Gly Ala Tyr Cys Asp Arg Val Leu Gln Ala Leu Ala Thr Ser 
                725                 730                 735     


Glu Gly Thr Leu Ile Glu Cys His Leu Val Gln Gly Ser Gly Asp Gly 
            740                 745                 750         


Gly Ser Leu Glu Ser Val Val Arg Val Phe Thr Pro Asp Asp Val Arg 
        755                 760                 765             


Glu Ala Arg Ala Gln Gly Ile Ser Phe Ser Ile His Val 
    770                 775                 780     


<210>  49
<211>  781
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:36 and encoded by SEQ ID NO:44

<400>  49

Met Gly Met Ile His Glu Gln Thr Asp Phe Thr Thr Ser Glu Ala Ile 
1               5                   10                  15      


Arg Pro Asp Thr Leu Ile Ser Pro Pro Asp Asp Trp Ala Phe Leu Gly 
            20                  25                  30          


Arg Pro Ser Arg Phe Asp Val Asp His Asp Gly Trp Ala Thr Val Gln 
        35                  40                  45              


Tyr Asp Ala Gly Leu Met Val Gly Val Ala Ala Leu Asp Asp Thr Val 
    50                  55                  60                  


Leu Arg Val Ala Tyr Cys Arg Ser Pro Gly Glu Trp Pro Thr Ser Thr 
65                  70                  75                  80  


Pro Ala Ile Val Glu Gln Met Ser Gln Arg His Ser Trp Arg Leu Val 
                85                  90                  95      


Gln Glu Glu Arg Arg Val Gln Leu Glu Cys Val Ala Gly Trp Gln Ile 
            100                 105                 110         


Gln Ile Asn Arg Asp Asp Gly Thr Trp Ser Ile Arg His Leu Gly Phe 
        115                 120                 125             


Gly Thr Ala Val Glu Ala Ile Thr Trp Tyr Lys Arg Lys Lys Gly Gly 
    130                 135                 140                 


Ala Leu Thr Phe Ala Ser Leu Asp Asn Ala Arg Phe Tyr Gly Leu Gly 
145                 150                 155                 160 


Glu Lys Pro Gly Pro Leu Asp Lys Arg His Glu Ala Tyr Thr Met Trp 
                165                 170                 175     


Asn Ser Asp Val Tyr Ala Pro His Val Pro Glu Met Glu Ala Leu Tyr 
            180                 185                 190         


Leu Ser Ile Pro Phe Phe Leu Arg Leu Gln Asp Gln Thr Ala Val Gly 
        195                 200                 205             


Ile Phe Val Asp Asn Pro Gly Arg Ser Arg Phe Asp Phe Arg Ser Arg 
    210                 215                 220                 


Tyr Pro Asp Val Glu Ile Ser Thr Glu Arg Gly Gly Leu Asp Val Tyr 
225                 230                 235                 240 


Phe Ile Phe Gly Ala Ser Leu Lys Asp Val Ile Arg Arg Tyr Thr Lys 
                245                 250                 255     


Leu Thr Gly Arg Met Pro Met Pro Pro Lys Trp Ala Leu Gly Tyr His 
            260                 265                 270         


Gln Ser Arg Tyr Ser Tyr Glu Thr Gln Ser Glu Val Leu Ser Val Ala 
        275                 280                 285             


Gln Thr Phe Val Glu Arg Asp Ile Pro Val Asp Ala Leu Tyr Leu Asp 
    290                 295                 300                 


Ile His Tyr Met Asp Gly Tyr Arg Val Phe Thr Phe Asp Glu Arg Arg 
305                 310                 315                 320 


Phe Pro Asp Pro Ala Arg Met Cys Asp Glu Leu Arg Lys Leu Gly Val 
                325                 330                 335     


Arg Val Val Pro Ile Val Asp Pro Gly Val Lys Gln Asp Pro Glu Tyr 
            340                 345                 350         


Pro Val Tyr Met Asp Gly Leu Ala His Asn His Phe Cys Gln Thr Ala 
        355                 360                 365             


Glu Gly Gln Val Tyr Leu Gly Glu Val Trp Pro Gly Leu Ser Ala Phe 
    370                 375                 380                 


Pro Asp Phe Ala Ser Glu Glu Val Arg Ala Trp Trp Gly Lys Trp His 
385                 390                 395                 400 


Arg Val Tyr Thr Gln Met Gly Ile Glu Gly Ile Trp Asn Asp Met Asn 
                405                 410                 415     


Glu Pro Ala Val Phe Asn Glu Thr Lys Thr Met Asp Val Asn Val Val 
            420                 425                 430         


His Arg Gly Asp Gly Arg Leu Tyr Thr His Gly Glu Val His Asn Leu 
        435                 440                 445             


Tyr Gly Phe Trp Met Ala Glu Ala Thr Tyr Arg Gly Leu Lys Ala Gln 
    450                 455                 460                 


Leu Ala Gly Lys Arg Pro Phe Val Leu Thr Arg Ala Gly Tyr Ser Gly 
465                 470                 475                 480 


Ile Gln Arg Tyr Ala Ala Val Trp Thr Gly Asp Asn Arg Ser Phe Trp 
                485                 490                 495     


Glu His Met Ala Met Ala Ile Pro Met Val Leu Asn Met Gly Met Ser 
            500                 505                 510         


Gly Ile Pro Leu Gly Gly Pro Asp Val Gly Gly Phe Ala His His Ala 
        515                 520                 525             


Ser Gly Glu Leu Leu Ala Arg Trp Thr Gln Met Gly Ala Phe Phe Pro 
    530                 535                 540                 


Phe Phe Arg Asn His Ser Ala Met Gly Thr His Arg Gln Glu Pro Trp 
545                 550                 555                 560 


Ala Phe Gly Pro Thr Phe Glu Ala Val Ile Arg Arg Ala Ile Arg Leu 
                565                 570                 575     


Arg Tyr Arg Phe Leu Pro Tyr Leu Tyr Thr Leu Ala Arg Glu Ala His 
            580                 585                 590         


Glu Thr Gly Leu Pro Met Met Arg Pro Leu Val Leu Glu Tyr Pro Asp 
        595                 600                 605             


Asp Pro Asn Thr His His Val Asp Asp Gln Phe Leu Val Gly Ser Asp 
    610                 615                 620                 


Leu Leu Val Ala Pro Ile Leu Lys Pro Gly Met Ala His Arg Met Val 
625                 630                 635                 640 


Tyr Leu Pro Asp Gly Glu Trp Ile Asp Tyr Glu Thr Arg Glu Arg Tyr 
                645                 650                 655     


Gln Gly Arg Gln Tyr Ile Leu Thr Tyr Ala Pro Leu Asp Arg Ile Pro 
            660                 665                 670         


Leu Tyr Val Arg Ala Gly Ser Ala Ile Pro Val Asn Leu Leu Glu Arg 
        675                 680                 685             


Ser Gly Glu Thr Gln Leu Gly Trp Glu Ile Phe Val Asp Ala Asn Gly 
    690                 695                 700                 


Arg Ala Ser Gly Arg Cys Tyr Glu Asp Asp Gly Glu Thr Phe Ser Tyr 
705                 710                 715                 720 


Glu Asp Gly Ala Tyr Cys Asp Arg Val Leu Gln Ala Leu Ala Thr Ser 
                725                 730                 735     


Glu Gly Thr Leu Ile Glu Cys His Leu Val Gln Gly Ser Gly Asp Gly 
            740                 745                 750         


Gly Ser Leu Glu Ser Val Val Arg Val Phe Thr Pro Asp Asp Val Arg 
        755                 760                 765             


Glu Ala Arg Ala Gln Gly Ile Ser Phe Ser Ile His Val 
    770                 775                 780     


<210>  50
<211>  781
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:36 and encoded by SEQ ID NO:45

<400>  50

Met Gly Met Ile His Glu Gln Thr Asp Phe Thr Thr Ser Glu Ala Ile 
1               5                   10                  15      


Arg Pro Asp Thr Leu Ile Ser Pro Pro Asp Asp Trp Ala Phe Leu Gly 
            20                  25                  30          


Arg Pro Ser Arg Phe Asp Val Asp His Asp Gly Trp Ala Thr Val Gln 
        35                  40                  45              


Tyr Asp Ala Gly Ile Met Val Gly Val Ala Ala Leu Asp Asp Thr Val 
    50                  55                  60                  


Leu Arg Val Ala Tyr Cys Arg Ser Pro Gly Glu Trp Pro Thr Ser Thr 
65                  70                  75                  80  


Pro Ala Ile Val Glu Gln Met Ser Gln Arg His Ser Trp Arg Leu Val 
                85                  90                  95      


Gln Glu Glu Arg Arg Val Gln Leu Glu Cys Val Ala Gly Trp Gln Ile 
            100                 105                 110         


Gln Ile Asn Arg Asp Asp Gly Thr Trp Ser Ile Arg His Leu Gly Phe 
        115                 120                 125             


Gly Thr Ala Val Glu Ala Ile Thr Trp Tyr Lys Arg Lys Lys Gly Gly 
    130                 135                 140                 


Ala Leu Thr Phe Ala Ser Leu Asp Asn Ala Arg Phe Tyr Gly Leu Gly 
145                 150                 155                 160 


Glu Lys Pro Gly Pro Leu Asp Lys Arg His Glu Ala Tyr Thr Met Trp 
                165                 170                 175     


Asn Ser Asp Val Tyr Ala Pro His Val Pro Glu Met Glu Ala Leu Tyr 
            180                 185                 190         


Leu Ser Ile Pro Phe Phe Leu Arg Leu Gln Asp Gln Thr Ala Val Gly 
        195                 200                 205             


Ile Phe Val Asp Asn Pro Gly Arg Ser Arg Phe Asp Phe Arg Ser Arg 
    210                 215                 220                 


Tyr Pro Asp Val Glu Ile Ser Thr Glu Arg Gly Gly Leu Asp Val Tyr 
225                 230                 235                 240 


Phe Ile Phe Gly Ala Ser Leu Lys Asp Val Ile Arg Arg Tyr Thr Lys 
                245                 250                 255     


Leu Thr Gly Arg Met Pro Met Pro Pro Lys Trp Ala Leu Gly Tyr His 
            260                 265                 270         


Gln Ser Arg Tyr Ser Tyr Glu Thr Gln Ser Glu Val Leu Ser Val Ala 
        275                 280                 285             


Gln Thr Phe Val Glu Arg Asp Ile Pro Val Asp Ala Leu Tyr Leu Asp 
    290                 295                 300                 


Ile His Tyr Met Asp Gly Tyr Arg Val Phe Thr Phe Asp Glu Arg Arg 
305                 310                 315                 320 


Phe Pro Asp Pro Ala Arg Met Cys Asp Glu Leu Arg Lys Leu Gly Val 
                325                 330                 335     


Arg Val Val Pro Ile Val Asp Pro Gly Val Lys Gln Asp Pro Glu Tyr 
            340                 345                 350         


Pro Val Tyr Met Asp Gly Leu Ala His Asn His Phe Cys Gln Thr Ala 
        355                 360                 365             


Glu Gly Gln Val Tyr Leu Gly Glu Val Trp Pro Gly Leu Ser Ala Phe 
    370                 375                 380                 


Pro Asp Phe Ala Ser Glu Glu Val Arg Ala Trp Trp Gly Lys Trp His 
385                 390                 395                 400 


Arg Val Tyr Thr Gln Met Gly Ile Glu Gly Ile Trp Asn Asp Met Asn 
                405                 410                 415     


Glu Pro Ala Val Phe Asn Glu Thr Lys Thr Met Asp Val Asn Val Val 
            420                 425                 430         


His Arg Gly Asp Gly Arg Leu Tyr Thr His Gly Glu Val His Asn Leu 
        435                 440                 445             


Tyr Gly Phe Trp Met Ala Glu Ala Thr Tyr Arg Gly Leu Lys Ala Gln 
    450                 455                 460                 


Leu Ala Gly Lys Arg Pro Phe Val Leu Thr Arg Ala Gly Tyr Ser Gly 
465                 470                 475                 480 


Ile Gln Arg Tyr Ala Ala Val Trp Thr Gly Asp Asn Arg Ser Phe Trp 
                485                 490                 495     


Glu His Met Ala Met Ala Ile Pro Met Val Leu Asn Met Gly Met Ser 
            500                 505                 510         


Gly Ile Pro Leu Gly Gly Pro Asp Val Gly Gly Phe Ala His His Ala 
        515                 520                 525             


Ser Gly Glu Leu Leu Ala Arg Trp Thr Gln Met Gly Ala Phe Phe Pro 
    530                 535                 540                 


Phe Phe Arg Asn His Ser Ala Met Gly Thr His Arg Gln Glu Pro Trp 
545                 550                 555                 560 


Ala Phe Gly Pro Thr Phe Glu Ala Val Ile Arg Arg Ala Ile Arg Leu 
                565                 570                 575     


Arg Tyr Arg Phe Leu Pro Tyr Leu Tyr Thr Leu Ala Arg Glu Ala His 
            580                 585                 590         


Glu Thr Gly Leu Pro Met Met Arg Pro Leu Val Leu Glu Tyr Pro Asp 
        595                 600                 605             


Asp Pro Asn Thr His His Val Asp Asp Gln Phe Leu Val Gly Ser Asp 
    610                 615                 620                 


Leu Leu Val Ala Pro Ile Leu Lys Pro Gly Met Ala His Arg Met Val 
625                 630                 635                 640 


Tyr Leu Pro Asp Gly Glu Trp Ile Asp Tyr Glu Thr Arg Glu Arg Tyr 
                645                 650                 655     


Gln Gly Arg Gln Tyr Ile Leu Thr Tyr Ala Pro Leu Asp Arg Ile Pro 
            660                 665                 670         


Leu Tyr Val Arg Ala Gly Ser Ala Ile Pro Val Asn Leu Leu Glu Arg 
        675                 680                 685             


Ser Gly Glu Thr Gln Leu Gly Trp Glu Ile Phe Val Asp Ala Asn Gly 
    690                 695                 700                 


Arg Ala Ser Gly Arg Cys Tyr Glu Asp Asp Gly Glu Thr Phe Ser Tyr 
705                 710                 715                 720 


Glu Asp Gly Ala Tyr Cys Asp Arg Val Leu Gln Ala Leu Ala Thr Ser 
                725                 730                 735     


Glu Gly Thr Leu Ile Glu Cys His Leu Val Gln Gly Ser Gly Asp Gly 
            740                 745                 750         


Gly Ser Leu Glu Ser Val Val Arg Val Phe Thr Pro Asp Asp Val Arg 
        755                 760                 765             


Glu Ala Arg Ala Gln Gly Ile Ser Phe Ser Ile His Val 
    770                 775                 780     


<210>  51
<211>  2340
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  51
atgaagttca ccgacggcaa ctggcttgtc cgcgaaggcg tctccattca tcccggcctc     60

gccgtgcagg aatggcggca agagggagac ggcgtcctct tcttcgtcgc gtgccgcccc    120

gtggcgcacc gcggccacat gctcgatggc cccatgctca cctgccgcat ctcctttccc    180

cggcctggta tggtgcgggt ggagcagcat cactttttcg gccggatgcc ccgcgggccc    240

catttcccgc ttgagctcaa acctcagccg tttgacgcgg cggagacgga ggacggtgtc    300

gtcctgcgcg ccggcgagat ggaggtgcgc gtgcggctgt ccccatggtc catcgcgttt    360

tacgagaacg gccgctttct caccgagagc ggccctcggt cgaccgcgta cgtcgtcgat    420

cacggccgcc cccacatgcg cggccaattg catctgtccg tgggtgaaaa cgtctatggc    480

cttggcgagc ggtttacggc gttcgtcaag aacggccagt ccctcgacat ctggaaccga    540

gacggcggga cgggatcgga ccaggcgtac aagaacgtac ccttctatct taccaaccgc    600

ggctacggcg tgttcgtgaa ccatcccgag cgcgtgtggt ttgaaatcgg gacggagttc    660

gtgtccaagg tgcagttcag cgtcgagggg gaggcgctcg attacgtggt cattggcggc    720

tgccatccga agggcgtgat cgagcgatac acggcgctca cggggcggcc ggcgctgccg    780

ccgatgtggt cgtttgggct gtggttgtcg acgtcgttca ccaccgacta tgacgaggag    840

acggtcagcc agtttgtcga cggcatggcg tctcgcggca ttccgctgag cgtattccac    900

ttcgactgtt tctggatgaa gccgtttgag tggtgcaact tcgcgtggga caccgcctgc    960

ttccccgatc cggcgggcat gctcgcgcgc ctcaaatccc gcgggttgcg catctgcgtc   1020

tggatcaacc cctacatcgc gcagaaatcg ccgcttttcc gcgaggcgat ggagcgcggc   1080

tacctgctca aacgcccgaa cggcgacgtg tggcagtggg acctgtggca gccgggcatg   1140

ggcatcgtcg acttcacaaa ccccgacgcc cgccgctggt accagtccca cctgcgtcgg   1200

ctgctcgaca tgggcgtcga tgcgttcaaa acggacttcg gcgagcggat tccgacggat   1260

gtggtgtacc acgacggatc ggacccgcaa aagatgcaca acttctacag ctacctgtac   1320

aacgaggctg tgtgggaagt cctccgcgag cggggaggcg gtgaagcatt ggtctttgcg   1380

cgatccgcca ccgctggcgg ccagcgcttc ccggtgcact ggggcggcga ctgccgggcc   1440

acgtacgaat ccatggcgga gacgcttcgc ggtggcctga gcctcgcctt gtccggcttc   1500

ggattctgga gccacgacat cggcgggttt gaggacacag cccccgccca cctgtacaag   1560

cgctggattg cctttgggct cttctcgagc cacagccgcc tgcacggaag cggatcgtac   1620

cgcgtgccgt ggctgttcga cgaggagtcg gtggacgttt tgcgccactt cacgcggtgg   1680

aagctccggc tcatgccata tctttggtcg tgcgccgtcg aggcgcaccg cacgggcgtg   1740

cccatgctgc gccccatgat gctcgaattt ccggacgatc cgacctgcga caccttggac   1800

cgccaatata tgctcggccc gtcgcttctc gtcgcgccgg tgttctcgga gacgggtgag   1860

gtcgtgtact atctcccgga agggcgctgg acgcacctgt tcaccggaga gacgaggcaa   1920

ggcggcagat ggtaccgcga acggtacgat ttcatgagcc tgcctgtgtt cgtgcgcgaa   1980

ggcagcatcc tggccatggg cgcggaaacg gaccggccta accaacccta ccaccgcgag   2040

gtggccatcc acgtctatcc catccggccg gaccatcgca gtgcgtgcac tctgtttgac   2100

gaacagggca acgaattggg cacatggcat gccttctggg atggagacca tctggtcctc   2160

accgcgcaag gtcggagcga ggcatggagc gccgtattgc acggtatcga cgatccggca   2220

aagctcgccg cgcagggcgc ggaatgccgc gtctcacccg agggagtcgt gatcagcccg   2280

caccatccac aggaggcggt gcgggtggca ggttgccggg agcaatggcg ggcggaatga   2340


<210>  52
<211>  779
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  52

Met Lys Phe Thr Asp Gly Asn Trp Leu Val Arg Glu Gly Val Ser Ile 
1               5                   10                  15      


His Pro Gly Leu Ala Val Gln Glu Trp Arg Gln Glu Gly Asp Gly Val 
            20                  25                  30          


Leu Phe Phe Val Ala Cys Arg Pro Val Ala His Arg Gly His Met Leu 
        35                  40                  45              


Asp Gly Pro Met Leu Thr Cys Arg Ile Ser Phe Pro Arg Pro Gly Met 
    50                  55                  60                  


Val Arg Val Glu Gln His His Phe Phe Gly Arg Met Pro Arg Gly Pro 
65                  70                  75                  80  


His Phe Pro Leu Glu Leu Lys Pro Gln Pro Phe Asp Ala Ala Glu Thr 
                85                  90                  95      


Glu Asp Gly Val Val Leu Arg Ala Gly Glu Met Glu Val Arg Val Arg 
            100                 105                 110         


Leu Ser Pro Trp Ser Ile Ala Phe Tyr Glu Asn Gly Arg Phe Leu Thr 
        115                 120                 125             


Glu Ser Gly Pro Arg Ser Thr Ala Tyr Val Val Asp His Gly Arg Pro 
    130                 135                 140                 


His Met Arg Gly Gln Leu His Leu Ser Val Gly Glu Asn Val Tyr Gly 
145                 150                 155                 160 


Leu Gly Glu Arg Phe Thr Ala Phe Val Lys Asn Gly Gln Ser Leu Asp 
                165                 170                 175     


Ile Trp Asn Arg Asp Gly Gly Thr Gly Ser Asp Gln Ala Tyr Lys Asn 
            180                 185                 190         


Val Pro Phe Tyr Leu Thr Asn Arg Gly Tyr Gly Val Phe Val Asn His 
        195                 200                 205             


Pro Glu Arg Val Trp Phe Glu Ile Gly Thr Glu Phe Val Ser Lys Val 
    210                 215                 220                 


Gln Phe Ser Val Glu Gly Glu Ala Leu Asp Tyr Val Val Ile Gly Gly 
225                 230                 235                 240 


Cys His Pro Lys Gly Val Ile Glu Arg Tyr Thr Ala Leu Thr Gly Arg 
                245                 250                 255     


Pro Ala Leu Pro Pro Met Trp Ser Phe Gly Leu Trp Leu Ser Thr Ser 
            260                 265                 270         


Phe Thr Thr Asp Tyr Asp Glu Glu Thr Val Ser Gln Phe Val Asp Gly 
        275                 280                 285             


Met Ala Ser Arg Gly Ile Pro Leu Ser Val Phe His Phe Asp Cys Phe 
    290                 295                 300                 


Trp Met Lys Pro Phe Glu Trp Cys Asn Phe Ala Trp Asp Thr Ala Cys 
305                 310                 315                 320 


Phe Pro Asp Pro Ala Gly Met Leu Ala Arg Leu Lys Ser Arg Gly Leu 
                325                 330                 335     


Arg Ile Cys Val Trp Ile Asn Pro Tyr Ile Ala Gln Lys Ser Pro Leu 
            340                 345                 350         


Phe Arg Glu Ala Met Glu Arg Gly Tyr Leu Leu Lys Arg Pro Asn Gly 
        355                 360                 365             


Asp Val Trp Gln Trp Asp Leu Trp Gln Pro Gly Met Gly Ile Val Asp 
    370                 375                 380                 


Phe Thr Asn Pro Asp Ala Arg Arg Trp Tyr Gln Ser His Leu Arg Arg 
385                 390                 395                 400 


Leu Leu Asp Met Gly Val Asp Ala Phe Lys Thr Asp Phe Gly Glu Arg 
                405                 410                 415     


Ile Pro Thr Asp Val Val Tyr His Asp Gly Ser Asp Pro Gln Lys Met 
            420                 425                 430         


His Asn Phe Tyr Ser Tyr Leu Tyr Asn Glu Ala Val Trp Glu Val Leu 
        435                 440                 445             


Arg Glu Arg Gly Gly Gly Glu Ala Leu Val Phe Ala Arg Ser Ala Thr 
    450                 455                 460                 


Ala Gly Gly Gln Arg Phe Pro Val His Trp Gly Gly Asp Cys Arg Ala 
465                 470                 475                 480 


Thr Tyr Glu Ser Met Ala Glu Thr Leu Arg Gly Gly Leu Ser Leu Ala 
                485                 490                 495     


Leu Ser Gly Phe Gly Phe Trp Ser His Asp Ile Gly Gly Phe Glu Asp 
            500                 505                 510         


Thr Ala Pro Ala His Leu Tyr Lys Arg Trp Ile Ala Phe Gly Leu Phe 
        515                 520                 525             


Ser Ser His Ser Arg Leu His Gly Ser Gly Ser Tyr Arg Val Pro Trp 
    530                 535                 540                 


Leu Phe Asp Glu Glu Ser Val Asp Val Leu Arg His Phe Thr Arg Trp 
545                 550                 555                 560 


Lys Leu Arg Leu Met Pro Tyr Leu Trp Ser Cys Ala Val Glu Ala His 
                565                 570                 575     


Arg Thr Gly Val Pro Met Leu Arg Pro Met Met Leu Glu Phe Pro Asp 
            580                 585                 590         


Asp Pro Thr Cys Asp Thr Leu Asp Arg Gln Tyr Met Leu Gly Pro Ser 
        595                 600                 605             


Leu Leu Val Ala Pro Val Phe Ser Glu Thr Gly Glu Val Val Tyr Tyr 
    610                 615                 620                 


Leu Pro Glu Gly Arg Trp Thr His Leu Phe Thr Gly Glu Thr Arg Gln 
625                 630                 635                 640 


Gly Gly Arg Trp Tyr Arg Glu Arg Tyr Asp Phe Met Ser Leu Pro Val 
                645                 650                 655     


Phe Val Arg Glu Gly Ser Ile Leu Ala Met Gly Ala Glu Thr Asp Arg 
            660                 665                 670         


Pro Asn Gln Pro Tyr His Arg Glu Val Ala Ile His Val Tyr Pro Ile 
        675                 680                 685             


Arg Pro Asp His Arg Ser Ala Cys Thr Leu Phe Asp Glu Gln Gly Asn 
    690                 695                 700                 


Glu Leu Gly Thr Trp His Ala Phe Trp Asp Gly Asp His Leu Val Leu 
705                 710                 715                 720 


Thr Ala Gln Gly Arg Ser Glu Ala Trp Ser Ala Val Leu His Gly Ile 
                725                 730                 735     


Asp Asp Pro Ala Lys Leu Ala Ala Gln Gly Ala Glu Cys Arg Val Ser 
            740                 745                 750         


Pro Glu Gly Val Val Ile Ser Pro His His Pro Gln Glu Ala Val Arg 
        755                 760                 765             


Val Ala Gly Cys Arg Glu Gln Trp Arg Ala Glu 
    770                 775                 


<210>  53
<211>  772
<212>  PRT
<213>  Escherichia coli 

<400>  53

Met Lys Ile Ser Asp Gly Asn Trp Leu Ile Gln Pro Gly Leu Asn Leu 
1               5                   10                  15      


Ile His Pro Leu Gln Val Phe Glu Val Glu Gln Gln Asp Asn Glu Met 
            20                  25                  30          


Val Val Tyr Ala Ala Pro Arg Asp Val Arg Glu Arg Thr Trp Gln Leu 
        35                  40                  45              


Asp Thr Pro Leu Phe Thr Leu Arg Phe Phe Ser Pro Gln Glu Gly Ile 
    50                  55                  60                  


Val Gly Val Arg Ile Glu His Phe Gln Gly Ala Leu Asn Asn Gly Pro 
65                  70                  75                  80  


His Tyr Pro Leu Asn Ile Leu Gln Asp Val Lys Val Thr Ile Glu Asn 
                85                  90                  95      


Thr Glu Arg Tyr Ala Glu Phe Lys Ser Gly Asn Leu Ser Ala Arg Val 
            100                 105                 110         


Ser Lys Gly Glu Phe Trp Ser Leu Asp Phe Leu Arg Asn Gly Glu Arg 
        115                 120                 125             


Ile Thr Gly Ser Gln Val Lys Asn Asn Gly Tyr Val Gln Asp Thr Asn 
    130                 135                 140                 


Asn Gln Arg Asn Tyr Met Phe Glu Arg Leu Asp Leu Gly Val Gly Glu 
145                 150                 155                 160 


Thr Val Tyr Gly Leu Gly Glu Arg Phe Thr Ala Leu Val Arg Asn Gly 
                165                 170                 175     


Gln Thr Val Glu Thr Trp Asn Arg Asp Gly Gly Thr Ser Thr Glu Gln 
            180                 185                 190         


Ala Tyr Lys Asn Ile Pro Phe Tyr Met Thr Asn Arg Gly Tyr Gly Val 
        195                 200                 205             


Leu Val Asn His Pro Gln Cys Val Ser Phe Glu Val Gly Ser Glu Lys 
    210                 215                 220                 


Val Ser Lys Val Gln Phe Ser Val Glu Ser Glu Tyr Leu Glu Tyr Phe 
225                 230                 235                 240 


Val Ile Asp Gly Pro Thr Pro Lys Ala Val Leu Asp Arg Tyr Thr Arg 
                245                 250                 255     


Phe Thr Gly Arg Pro Ala Leu Pro Pro Ala Trp Ser Phe Gly Leu Trp 
            260                 265                 270         


Leu Thr Thr Ser Phe Thr Thr Asn Tyr Asp Glu Ala Thr Val Asn Ser 
        275                 280                 285             


Phe Ile Asp Gly Met Ala Glu Arg Asn Leu Pro Leu His Val Phe His 
    290                 295                 300                 


Phe Asp Cys Phe Trp Met Lys Ala Phe Gln Trp Cys Asp Phe Glu Trp 
305                 310                 315                 320 


Asp Pro Leu Thr Phe Pro Asp Pro Glu Gly Met Ile Arg Arg Leu Lys 
                325                 330                 335     


Ala Lys Gly Leu Lys Ile Cys Val Trp Ile Asn Pro Tyr Ile Gly Gln 
            340                 345                 350         


Lys Ser Pro Val Phe Lys Glu Leu Gln Glu Lys Gly Tyr Leu Leu Lys 
        355                 360                 365             


Arg Pro Asp Gly Ser Leu Trp Gln Trp Asp Lys Trp Gln Pro Gly Leu 
    370                 375                 380                 


Ala Ile Tyr Asp Phe Thr Asn Pro Asp Ala Cys Lys Trp Tyr Ala Asp 
385                 390                 395                 400 


Lys Leu Lys Gly Leu Val Ala Met Gly Val Asp Cys Phe Lys Thr Asp 
                405                 410                 415     


Phe Gly Glu Arg Ile Pro Thr Asp Val Gln Trp Phe Asp Gly Ser Asp 
            420                 425                 430         


Pro Gln Lys Met His Asn His Tyr Ala Tyr Ile Tyr Asn Glu Leu Val 
        435                 440                 445             


Trp Asn Val Leu Lys Asp Thr Val Gly Glu Glu Glu Ala Val Leu Phe 
    450                 455                 460                 


Ala Arg Ser Ala Ser Val Gly Ala Gln Lys Phe Pro Val His Trp Gly 
465                 470                 475                 480 


Gly Asp Cys Tyr Ala Asn Tyr Glu Ser Met Ala Glu Ser Leu Arg Gly 
                485                 490                 495     


Gly Leu Ser Ile Gly Leu Ser Gly Phe Gly Phe Trp Ser His Asp Ile 
            500                 505                 510         


Gly Gly Phe Glu Asn Thr Ala Pro Ala His Val Tyr Lys Arg Trp Cys 
        515                 520                 525             


Ala Phe Gly Leu Leu Ser Ser His Ser Arg Leu His Gly Ser Lys Ser 
    530                 535                 540                 


Tyr Arg Val Pro Trp Ala Tyr Asp Asp Glu Ser Cys Asp Val Val Arg 
545                 550                 555                 560 


Phe Phe Thr Gln Leu Lys Cys Arg Met Met Pro Tyr Leu Tyr Arg Glu 
                565                 570                 575     


Ala Ala Arg Ala Asn Ala Arg Gly Thr Pro Met Met Arg Ala Met Met 
            580                 585                 590         


Met Glu Phe Pro Asp Asp Pro Ala Cys Asp Tyr Leu Asp Arg Gln Tyr 
        595                 600                 605             


Met Leu Gly Asp Asn Val Met Val Ala Pro Val Phe Thr Glu Ala Gly 
    610                 615                 620                 


Asp Val Gln Phe Tyr Leu Pro Glu Gly Arg Trp Thr His Leu Trp His 
625                 630                 635                 640 


Asn Asp Glu Leu Asp Gly Ser Arg Trp His Lys Gln Gln His Gly Phe 
                645                 650                 655     


Leu Ser Leu Pro Val Tyr Val Arg Asp Asn Thr Leu Leu Ala Leu Gly 
            660                 665                 670         


Asn Asn Asp Gln Arg Pro Asp Tyr Val Trp His Glu Gly Thr Ala Phe 
        675                 680                 685             


His Leu Phe Asn Leu Gln Asp Gly His Glu Ala Val Cys Glu Val Pro 
    690                 695                 700                 


Ala Ala Asp Gly Ser Val Ile Phe Thr Leu Lys Ala Ala Arg Thr Gly 
705                 710                 715                 720 


Asn Thr Ile Thr Val Thr Gly Ala Gly Glu Ala Lys Asn Trp Thr Leu 
                725                 730                 735     


Cys Leu Arg Asn Val Val Lys Val Asn Gly Leu Gln Asp Gly Ser Gln 
            740                 745                 750         


Ala Glu Ser Glu Gln Gly Leu Val Val Lys Pro Gln Gly Asn Ala Leu 
        755                 760                 765             


Thr Ile Thr Leu 
    770         


<210>  54
<211>  769
<212>  PRT
<213>  Bacillus licheniformis 

<400>  54

Met Lys Phe Ser Asp Gly Tyr Trp Leu Thr Arg Glu Gly Tyr His Ile 
1               5                   10                  15      


Asn Thr Pro Lys Glu Ala Tyr Asp Arg Met Ile Asp Gln Gln Ser Leu 
            20                  25                  30          


Thr Val Tyr Gly Pro Val Lys Ala Val Gln Lys Arg Gly Asp Thr Leu 
        35                  40                  45              


Asp Thr Arg Met Leu Thr Val Arg Phe Ser Ser Pro Leu Glu Asp Met 
    50                  55                  60                  


Ile Arg Val Gln Val Phe His Phe Gln Gly Glu Thr Pro Arg Lys Pro 
65                  70                  75                  80  


Asp Phe Gln Leu His Thr Ala Asp Val Glu Pro Val Ile Thr Glu His 
                85                  90                  95      


Asp Asp Ala Leu Thr Phe Gln Ser Gly Ser Leu Cys Val Glu Val Ser 
            100                 105                 110         


Lys Asn Gly Trp Gly Tyr Gln Phe Ser Arg Asp Gly Gln Ser Leu Thr 
        115                 120                 125             


Ala Ser Glu Ser Asn Ser Leu Ala Tyr Ile Thr Ser Asp Asp Gly Arg 
    130                 135                 140                 


Thr Phe Met Arg Glu Gln Leu Asn Ile Gly Val Gly Glu Leu Leu Tyr 
145                 150                 155                 160 


Gly Leu Gly Glu Arg Phe Thr Ala Phe Val Lys Asn Gly Gln Thr Val 
                165                 170                 175     


Asp Ile Trp Asn Gln Asp Gly Gly Thr Ser Thr Glu Gln Ala Tyr Lys 
            180                 185                 190         


Asn Val Pro Phe Tyr Leu Ser Asn Lys Gly Tyr Gly Val Phe Val Asn 
        195                 200                 205             


His Pro Glu Leu Val Ser Tyr Glu Ile Gly Ser Glu Val Val Ser Lys 
    210                 215                 220                 


Ala Gln Phe Ser Val Glu Gly Glu Ser Leu Asp Tyr Phe Val Ile Ser 
225                 230                 235                 240 


Gly Ala Glu Pro Lys Asp Val Leu Lys Arg Tyr Ala Ala Leu Thr Gly 
                245                 250                 255     


Lys Pro Ala Leu Pro Pro Ala Trp Ser Phe Gly Leu Trp Leu Ser Thr 
            260                 265                 270         


Ser Phe Thr Thr Asp Tyr Ser Glu Glu Thr Val Thr Arg Phe Ile Asp 
        275                 280                 285             


Gly Met Thr Glu Arg Gly Ile Pro Leu Ser Val Phe His Phe Asp Cys 
    290                 295                 300                 


Phe Trp Met Lys Glu Phe Glu Trp Cys Asn Phe Glu Trp Asp Glu Arg 
305                 310                 315                 320 


Tyr Phe Lys Gln Pro Glu Ala Met Leu Ser Arg Leu Lys Glu Lys Gly 
                325                 330                 335     


Leu Lys Ile Cys Val Trp Ile Asn Pro Tyr Ile Ala Gln Lys Ser Lys 
            340                 345                 350         


Leu Phe Gln Glu Gly Lys Glu Asn Gly Tyr Phe Leu Lys Asn Ser Arg 
        355                 360                 365             


Gly Asp Val Trp Gln Trp Asp Arg Trp Gln Ala Gly Met Ala Ile Val 
    370                 375                 380                 


Asp Phe Thr Asn Glu Lys Ala Arg Asp Trp Tyr Cys Ser Lys Leu Glu 
385                 390                 395                 400 


Ser Leu Leu Asp Met Gly Val Asp Cys Phe Lys Thr Asp Phe Gly Glu 
                405                 410                 415     


Arg Ile Pro Ser Asp Ala Val Tyr Phe Asp Gly Ser Asp Pro Glu Arg 
            420                 425                 430         


Met His Asn Tyr Tyr Ser Tyr Leu Tyr Asn Lys Thr Val Phe Asp Leu 
        435                 440                 445             


Leu Arg Gln Lys Arg Gly Glu Arg Glu Ala Val Val Phe Ala Arg Ser 
    450                 455                 460                 


Ala Thr Ala Gly Gly Gln Gln Phe Pro Val His Trp Gly Gly Asp Cys 
465                 470                 475                 480 


Phe Ala Ser Tyr Asp Ser Met Ala Glu Ser Leu Arg Gly Gly Leu Ser 
                485                 490                 495     


Leu Ser Leu Ser Gly Phe Gly Phe Trp Ser His Asp Ile Gly Gly Phe 
            500                 505                 510         


Glu Ser Thr Ala Thr Ala Asp Leu Tyr Lys Arg Trp Thr Ala Phe Gly 
        515                 520                 525             


Leu Leu Ser Thr His Ser Arg Leu His Gly Ser Glu Ser Tyr Arg Val 
    530                 535                 540                 


Pro Trp Leu Phe Asp Glu Glu Ala Ala Asp Val Met Arg Tyr Phe Val 
545                 550                 555                 560 


Lys Leu Lys His Arg Leu Met Pro Tyr Leu Tyr Ala Ala Ala His Glu 
                565                 570                 575     


Ala His Ala Glu Gly Ile Pro Met Met Arg Ala Met Leu Leu Glu Phe 
            580                 585                 590         


Pro Gly Asp Asn Thr Cys His Trp Leu Asp Arg Gln Tyr Met Leu Gly 
        595                 600                 605             


Gly Arg Leu Leu Val Ala Pro Val Phe Gln Glu Asp Gly Ala Val Arg 
    610                 615                 620                 


Tyr Tyr Leu Pro Lys Gly Thr Trp Thr His Leu Leu Thr Gly Lys Glu 
625                 630                 635                 640 


Thr Glu Gly Gly Glu Trp Lys Glu Glu Arg Tyr Gly Tyr Met Arg Leu 
                645                 650                 655     


Pro Leu Phe Val Arg Glu Asn Thr Leu Leu Pro Leu Gly Gln Glu Ser 
            660                 665                 670         


Gly Arg Pro Asp Tyr Asp Tyr Leu Asp Asp Val Thr Phe Cys Leu Tyr 
        675                 680                 685             


His Leu Lys Asp Gly Cys Thr Ala Glu Gln Thr Ile Tyr Asn Glu Lys 
    690                 695                 700                 


Gly Glu Ala Met Thr Leu Arg Ala Ser Arg His Gln Asn Thr Ile Ala 
705                 710                 715                 720 


Val Lys Thr Thr Gly Val Gln Lys Asn Trp Lys Leu Leu Leu Arg Gly 
                725                 730                 735     


Leu Ser Val Thr Ser Val Ile Asn Gly Ala Ala Glu Ala Leu Gln Glu 
            740                 745                 750         


Gly Thr Ala Val Gln Pro Lys Glu Lys Glu Arg Asp Val Phe Ile Tyr 
        755                 760                 765             


Phe 
    


<210>  55
<211>  769
<212>  PRT
<213>  Bacillus licheniformis 

<400>  55

Met Lys Phe Ser Asp Gly Tyr Trp Leu Thr Arg Glu Gly Tyr His Ile 
1               5                   10                  15      


Asn Thr Pro Lys Glu Ala Tyr Asp Arg Met Ile Asp Gln Gln Ser Leu 
            20                  25                  30          


Thr Val Tyr Gly Pro Val Lys Ala Val Gln Lys Arg Gly Asp Thr Leu 
        35                  40                  45              


Asp Thr Arg Met Leu Thr Val Arg Phe Ser Ser Pro Leu Glu Asp Met 
    50                  55                  60                  


Ile Arg Val Gln Val Phe His Phe Gln Gly Glu Thr Pro Arg Lys Pro 
65                  70                  75                  80  


Asp Phe Gln Leu His Thr Ala Asp Val Glu Pro Val Ile Thr Glu His 
                85                  90                  95      


Asp Asp Ala Leu Thr Phe Gln Ser Gly Ser Leu Cys Val Glu Val Ser 
            100                 105                 110         


Lys Asn Gly Trp Gly Tyr Gln Phe Ser Arg Asp Gly Gln Ser Leu Thr 
        115                 120                 125             


Ala Ser Glu Ser Asn Ser Leu Ala Tyr Ile Thr Ser Asp Asp Gly Arg 
    130                 135                 140                 


Thr Phe Met Arg Glu Gln Leu Asn Ile Gly Val Gly Glu Leu Leu Tyr 
145                 150                 155                 160 


Gly Leu Gly Glu Arg Phe Thr Ala Phe Val Lys Asn Gly Gln Thr Val 
                165                 170                 175     


Asp Ile Trp Asn Gln Asp Gly Gly Thr Ser Thr Glu Gln Ala Tyr Lys 
            180                 185                 190         


Asn Val Pro Phe Tyr Leu Ser Asn Lys Gly Tyr Gly Val Phe Val Asn 
        195                 200                 205             


His Pro Glu Leu Val Ser Tyr Glu Ile Gly Ser Glu Val Val Ser Lys 
    210                 215                 220                 


Ala Gln Phe Ser Val Glu Gly Glu Ser Leu Asp Tyr Phe Val Ile Ser 
225                 230                 235                 240 


Gly Ala Glu Pro Lys Asp Val Leu Lys Arg Tyr Ala Ala Leu Thr Gly 
                245                 250                 255     


Lys Pro Ala Leu Pro Pro Ala Trp Ser Phe Gly Leu Trp Leu Ser Thr 
            260                 265                 270         


Ser Phe Thr Thr Asp Tyr Ser Glu Glu Thr Val Thr Arg Phe Ile Asp 
        275                 280                 285             


Gly Met Thr Glu Arg Gly Ile Pro Leu Ser Val Phe His Phe Asp Cys 
    290                 295                 300                 


Phe Trp Met Lys Glu Phe Glu Trp Cys Asn Phe Glu Trp Asp Glu Arg 
305                 310                 315                 320 


Tyr Phe Lys Gln Pro Glu Ala Met Leu Ser Arg Leu Lys Glu Lys Gly 
                325                 330                 335     


Leu Lys Ile Cys Val Trp Ile Asn Pro Tyr Ile Ala Gln Lys Ser Lys 
            340                 345                 350         


Leu Phe Gln Glu Gly Lys Glu Asn Gly Tyr Phe Leu Lys Asn Ser Arg 
        355                 360                 365             


Gly Asp Val Trp Gln Trp Asp Arg Trp Gln Ala Gly Met Ala Ile Val 
    370                 375                 380                 


Asp Phe Thr Asn Glu Lys Ala Arg Asp Trp Tyr Cys Ser Lys Leu Glu 
385                 390                 395                 400 


Ser Leu Leu Asp Met Gly Val Asp Cys Phe Lys Thr Asp Phe Gly Glu 
                405                 410                 415     


Arg Ile Pro Ser Asp Ala Val Tyr Phe Asp Gly Ser Asp Pro Glu Arg 
            420                 425                 430         


Met His Asn Tyr Tyr Ser Tyr Leu Tyr Asn Lys Thr Val Phe Asp Leu 
        435                 440                 445             


Leu Arg Gln Lys Arg Gly Glu Arg Glu Ala Val Val Phe Ala Arg Ser 
    450                 455                 460                 


Ala Thr Ala Gly Gly Gln Gln Phe Pro Val His Trp Gly Gly Asp Cys 
465                 470                 475                 480 


Phe Ala Ser Tyr Asp Ser Met Ala Glu Ser Leu Arg Gly Gly Leu Ser 
                485                 490                 495     


Leu Ser Leu Ser Gly Phe Gly Phe Trp Ser His Asp Ile Gly Gly Phe 
            500                 505                 510         


Glu Ser Thr Ala Thr Ala Asp Leu Tyr Lys Arg Trp Thr Ala Phe Gly 
        515                 520                 525             


Leu Leu Ser Thr His Ser Arg Leu His Gly Ser Glu Ser Tyr Arg Val 
    530                 535                 540                 


Pro Trp Leu Phe Asp Glu Glu Ala Ala Asp Val Met Arg Tyr Phe Val 
545                 550                 555                 560 


Lys Leu Lys His Arg Leu Met Pro Tyr Leu Tyr Ala Ala Ala His Glu 
                565                 570                 575     


Ala His Ala Glu Gly Ile Pro Met Met Arg Ala Met Leu Leu Glu Phe 
            580                 585                 590         


Pro Gly Asp Asn Thr Cys His Trp Leu Asp Arg Gln Tyr Met Leu Gly 
        595                 600                 605             


Gly Arg Leu Leu Val Ala Pro Val Phe Gln Glu Asp Gly Ala Val Arg 
    610                 615                 620                 


Tyr Tyr Leu Pro Lys Gly Thr Trp Thr His Leu Leu Thr Gly Lys Glu 
625                 630                 635                 640 


Thr Glu Gly Gly Glu Trp Lys Glu Glu Arg Tyr Gly Tyr Met Arg Leu 
                645                 650                 655     


Pro Leu Phe Val Arg Glu Asn Thr Leu Leu Pro Leu Gly Gln Glu Ser 
            660                 665                 670         


Gly Arg Pro Asp Tyr Asp Tyr Leu Asp Asp Val Thr Phe Cys Leu Tyr 
        675                 680                 685             


His Leu Lys Asp Gly Cys Thr Ala Glu Gln Thr Ile Tyr Asn Glu Lys 
    690                 695                 700                 


Gly Glu Ala Met Thr Leu Arg Ala Ser Arg His Gln Asn Thr Ile Ala 
705                 710                 715                 720 


Val Lys Thr Thr Gly Val Gln Lys Asn Trp Lys Leu Leu Leu Arg Gly 
                725                 730                 735     


Leu Ser Val Thr Ser Val Ile Asn Gly Ala Ala Glu Ala Leu Gln Glu 
            740                 745                 750         


Gly Thr Ala Val Gln Pro Lys Glu Lys Glu Arg Asp Val Phe Ile Tyr 
        755                 760                 765             


Phe 
    


<210>  56
<211>  772
<212>  PRT
<213>  Salmonella enterica 

<400>  56

Met Lys Ile Ser Asp Gly Asn Trp Leu Ile Gln Pro Gly Leu Asn Leu 
1               5                   10                  15      


Ile His Pro Val Gln Val Phe Asp Val Glu Gln His Gly Asn Glu Met 
            20                  25                  30          


Val Val Tyr Ala Ala Pro Arg Asp Val Arg Glu Arg Thr Trp Gln Leu 
        35                  40                  45              


Asp Thr Pro Leu Phe Thr Leu Arg Phe Phe Ser Pro Gln Glu Gly Val 
    50                  55                  60                  


Ile Gly Val Arg Met Glu His Phe Gln Gly Ala Leu Asp Asn Gly Pro 
65                  70                  75                  80  


His Tyr Pro Leu Asn Val Leu Gln Asp Ile Asn Val Glu Met Gln Asn 
                85                  90                  95      


Asn Ala Glu Phe Ala Glu Leu Lys Ser Gly Ser Leu Ser Val Arg Val 
            100                 105                 110         


Thr Lys Gly Glu Leu Trp Ser Leu Asp Phe Leu Arg Asn Gly Val Arg 
        115                 120                 125             


Ile Thr Gly Ser Gln Leu Lys Asn Asn Gly Tyr Val Gln Asp Thr Asn 
    130                 135                 140                 


Ser Gly Arg Asn Tyr Met Phe Glu Arg Leu Asp Leu Gly Val Gly Glu 
145                 150                 155                 160 


Thr Val Tyr Gly Leu Gly Glu Arg Phe Thr Ala Leu Val Arg Asn Gly 
                165                 170                 175     


Gln Thr Val Glu Thr Trp Asn Arg Asp Gly Gly Thr Ser Thr Glu Gln 
            180                 185                 190         


Ser Tyr Lys Asn Ile Pro Phe Tyr Ile Thr Asn Arg Gly Tyr Gly Val 
        195                 200                 205             


Leu Val Asn His Pro Gln Cys Val Ser Phe Glu Ile Gly Ser Glu Lys 
    210                 215                 220                 


Val Ser Lys Val Gln Phe Ser Val Glu Ser Glu Tyr Leu Glu Tyr Phe 
225                 230                 235                 240 


Val Ile Asp Gly Pro Thr Pro Lys Asp Val Leu Asn Arg Tyr Thr Gln 
                245                 250                 255     


Phe Thr Gly Arg Pro Ala Leu Pro Pro Ala Trp Ser Phe Gly Leu Trp 
            260                 265                 270         


Leu Thr Thr Ser Phe Thr Thr Asn Tyr Asp Glu Ala Thr Val Asn Arg 
        275                 280                 285             


Phe Ile Asp Gly Met Ala Glu Arg Asn Leu Pro Leu His Val Phe His 
    290                 295                 300                 


Phe Asp Cys Phe Trp Met Lys Ala Phe Gln Trp Cys Asp Phe Glu Trp 
305                 310                 315                 320 


Asp Pro Val Thr Phe Pro Asp Pro Lys Gly Met Ile His Arg Leu Lys 
                325                 330                 335     


Ala Lys Gly Leu Lys Val Cys Val Trp Ile Asn Pro Tyr Ile Gly Gln 
            340                 345                 350         


Lys Ser Pro Val Phe Gln Glu Leu Lys Glu Lys Gly Tyr Leu Leu Lys 
        355                 360                 365             


Arg Pro Asp Gly Ser Leu Trp Gln Trp Asp Lys Trp Gln Pro Gly Leu 
    370                 375                 380                 


Ala Ile Tyr Asp Phe Thr Asn Pro Gln Ala Cys Glu Trp Tyr Ala Asp 
385                 390                 395                 400 


Lys Leu Lys Gly Leu Val Glu Met Gly Val Asp Cys Phe Lys Thr Asp 
                405                 410                 415     


Phe Gly Glu Arg Ile Pro Thr Asp Val Gln Trp Phe Asp Gly Ser Asp 
            420                 425                 430         


Pro Gln Lys Met His Asn His Tyr Ala Tyr Ile Tyr Asn Glu Leu Val 
        435                 440                 445             


Trp Asn Val Leu Lys Glu Thr Val Gly Val Glu Glu Ala Val Leu Phe 
    450                 455                 460                 


Ala Arg Ser Ala Ser Val Gly Ala Gln Gln Phe Pro Val His Trp Gly 
465                 470                 475                 480 


Gly Asp Cys Tyr Ala Asn Tyr Glu Ser Met Ala Glu Ser Leu Arg Gly 
                485                 490                 495     


Gly Leu Ser Ile Gly Leu Ser Gly Phe Gly Phe Trp Ser His Asp Ile 
            500                 505                 510         


Gly Gly Phe Glu Asn Thr Ala Pro Ala His Val Tyr Lys Arg Trp Cys 
        515                 520                 525             


Ala Phe Gly Leu Leu Ser Ser His Ser Arg Leu His Gly Ser Lys Ser 
    530                 535                 540                 


Tyr Arg Val Pro Trp Ala Tyr Asp Asp Glu Ser Cys Asp Val Val Arg 
545                 550                 555                 560 


Phe Phe Thr Glu Gln Lys Cys Arg Met Met Pro Tyr Leu Tyr Arg Glu 
                565                 570                 575     


Ala Ala Arg Ala Asn Glu Ala Gly Thr Pro Met Met Arg Ala Met Met 
            580                 585                 590         


Leu Glu Phe Pro Asp Asp Pro Ala Cys Asp Tyr Leu Asp Arg Gln Tyr 
        595                 600                 605             


Met Leu Gly Asp Ala Val Met Val Ala Pro Val Phe Ser Glu Ala Gly 
    610                 615                 620                 


Asp Val Glu Phe Tyr Leu Pro Glu Gly Arg Trp Thr His Leu Trp Arg 
625                 630                 635                 640 


Asn Asp Glu Val Gln Gly Ser Arg Trp His Lys Gln Gln His Asp Phe 
                645                 650                 655     


Leu Ser Leu Pro Val Tyr Val Arg Asp Asn Thr Leu Leu Ala Leu Gly 
            660                 665                 670         


Asn Asn Ser Gln Lys Pro Asp Tyr Ala Trp His Glu Gly Thr Ala Phe 
        675                 680                 685             


Gln Leu Phe His Leu Asp Asp Gly Cys Glu Ala Val Cys Glu Val Pro 
    690                 695                 700                 


Ala Thr Asp Gly Ser Thr Ile Phe Thr Leu Gln Ala Lys Arg Thr Gly 
705                 710                 715                 720 


Asn Thr Ile Thr Val Ser Gly Glu Gly Glu Ala Arg Asn Trp Thr Leu 
                725                 730                 735     


Cys Leu Arg Asn Ile Thr Gln Ile Ser Gly Thr Lys Cys Gly Ser Tyr 
            740                 745                 750         


Ala Gly Ser Glu Leu Gly Val Val Val Thr Pro Gln Gly Asn Glu Val 
        755                 760                 765             


Val Ile Thr Leu 
    770         


<210>  57
<211>  772
<212>  PRT
<213>  Salmonella typhimurium

<400>  57

Met Lys Ile Ser Asp Gly Asn Trp Leu Ile Gln Pro Gly Leu Asn Leu 
1               5                   10                  15      


Ile His Pro Val Gln Val Phe Asp Val Glu Gln His Gly Asn Glu Met 
            20                  25                  30          


Val Ile Tyr Ala Ala Pro Arg Asp Val Arg Glu Arg Thr Trp Gln Leu 
        35                  40                  45              


Asp Thr Pro Leu Phe Thr Leu Arg Phe Phe Ser Pro Gln Glu Gly Val 
    50                  55                  60                  


Ile Gly Val Arg Met Glu His Phe Gln Gly Ala Leu Asp Asn Gly Pro 
65                  70                  75                  80  


His Tyr Pro Leu Asn Val Leu Gln Asp Ile Asn Val Glu Met Gln Asn 
                85                  90                  95      


Asn Ala Glu Phe Ala Glu Leu Lys Ser Gly Ser Leu Ser Val Arg Val 
            100                 105                 110         


Thr Lys Gly Glu Ile Trp Ser Leu Asp Phe Leu Arg Asn Gly Val Arg 
        115                 120                 125             


Ile Thr Gly Ser Gln Leu Lys Asn Asn Gly Tyr Val Gln Asp Thr Asn 
    130                 135                 140                 


Ser Gly Arg Asn Tyr Met Phe Glu Arg Leu Asp Leu Gly Val Gly Asp 
145                 150                 155                 160 


Thr Val Tyr Gly Leu Gly Glu Arg Phe Thr Ala Leu Val Arg Asn Gly 
                165                 170                 175     


Gln Thr Val Glu Thr Trp Asn Arg Asp Gly Gly Thr Ser Thr Glu Gln 
            180                 185                 190         


Ser Tyr Lys Asn Ile Pro Phe Tyr Ile Thr Asn Arg Gly Tyr Gly Val 
        195                 200                 205             


Leu Val Asn His Pro Gln Cys Val Ser Phe Glu Ile Gly Ser Glu Lys 
    210                 215                 220                 


Val Ser Lys Val Gln Phe Ser Val Glu Ser Glu Tyr Leu Glu Tyr Phe 
225                 230                 235                 240 


Val Ile Asp Gly Pro Thr Pro Lys Asp Val Leu Asn Arg Tyr Thr Gln 
                245                 250                 255     


Phe Thr Gly Arg Pro Ala Leu Pro Pro Ala Trp Ser Phe Gly Leu Trp 
            260                 265                 270         


Leu Thr Thr Ser Phe Thr Thr Asn Tyr Asp Glu Ala Thr Val Asn Ser 
        275                 280                 285             


Phe Ile Asp Gly Met Ala Glu Arg Asn Leu Pro Leu His Val Phe His 
    290                 295                 300                 


Phe Asp Cys Phe Trp Met Lys Ala Phe Gln Trp Cys Asp Phe Glu Trp 
305                 310                 315                 320 


Asp Pro Val Thr Phe Pro Asp Pro Lys Gly Met Ile Arg Arg Leu Lys 
                325                 330                 335     


Ala Lys Gly Leu Lys Val Cys Val Trp Ile Asn Pro Tyr Ile Gly Gln 
            340                 345                 350         


Lys Ser Pro Val Phe Gln Glu Leu Lys Glu Lys Gly Tyr Leu Leu Lys 
        355                 360                 365             


Arg Pro Asp Gly Ser Leu Trp Gln Trp Asp Lys Trp Gln Pro Gly Leu 
    370                 375                 380                 


Ala Ile Tyr Asp Phe Thr Asn Pro Gln Ala Cys Glu Trp Tyr Ala Asp 
385                 390                 395                 400 


Lys Leu Lys Gly Leu Val Glu Met Gly Val Asp Cys Phe Lys Thr Asp 
                405                 410                 415     


Phe Gly Glu Arg Ile Pro Thr Asp Val Gln Trp Phe Asp Gly Ser Asp 
            420                 425                 430         


Pro Gln Lys Met His Asn His Tyr Ala Tyr Ile Tyr Asn Glu Leu Val 
        435                 440                 445             


Trp Asn Val Leu Lys Glu Thr Val Gly Val Glu Glu Ala Val Leu Phe 
    450                 455                 460                 


Ala Arg Ser Ala Ser Val Gly Ala Gln Gln Phe Pro Val His Trp Gly 
465                 470                 475                 480 


Gly Asp Cys Tyr Ala Asn Tyr Glu Ser Met Ala Glu Ser Leu Arg Gly 
                485                 490                 495     


Gly Leu Ser Ile Gly Leu Ser Gly Phe Gly Phe Trp Ser His Asp Ile 
            500                 505                 510         


Gly Gly Phe Glu Asn Thr Ala Pro Ala His Val Tyr Lys Arg Trp Cys 
        515                 520                 525             


Ala Phe Gly Leu Leu Ser Ser His Ser Arg Leu His Gly Ser Lys Ser 
    530                 535                 540                 


Tyr Arg Val Pro Trp Ala Tyr Asp Asp Glu Ser Cys Asp Val Val Arg 
545                 550                 555                 560 


Phe Phe Thr Glu Gln Lys Cys Arg Met Met Pro Tyr Leu Tyr Arg Glu 
                565                 570                 575     


Ala Ala Arg Ala Asn Glu Ala Gly Thr Pro Met Met Arg Ala Met Met 
            580                 585                 590         


Leu Glu Phe Pro Asp Asp Pro Ala Cys Asp Tyr Leu Asp Arg Gln Tyr 
        595                 600                 605             


Met Leu Gly Asp Ala Val Met Val Ala Pro Val Phe Ser Glu Ala Gly 
    610                 615                 620                 


Asp Val Glu Phe Tyr Leu Pro Glu Gly Arg Trp Thr His Leu Trp Arg 
625                 630                 635                 640 


Asn Asp Glu Val Gln Gly Ser Arg Trp His Lys Gln Gln His Asp Phe 
                645                 650                 655     


Leu Ser Leu Pro Val Tyr Val Arg Asp Asn Thr Leu Leu Ala Leu Gly 
            660                 665                 670         


Asn Asn Ser Gln Lys Pro Asp Tyr Ala Trp His Glu Gly Thr Ala Phe 
        675                 680                 685             


Gln Leu Phe His Leu Asp Asp Gly Cys Glu Ala Val Cys Glu Val Pro 
    690                 695                 700                 


Ala Thr Asp Gly Ser Thr Ile Phe Thr Leu Gln Ala Lys Arg Thr Gly 
705                 710                 715                 720 


Asn Thr Ile Thr Val Ser Gly Glu Gly Lys Ala Arg Asn Trp Thr Leu 
                725                 730                 735     


Cys Leu Arg Asn Ile Thr Gln Ile Ser Gly Thr Lys Cys Gly Ser Tyr 
            740                 745                 750         


Ala Gly Ser Glu Leu Gly Val Val Val Thr Pro Gln Gly Asn Glu Val 
        755                 760                 765             


Val Ile Thr Leu 
    770         


<210>  58
<211>  2340
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 51

<400>  58
atgaggttca ccgacggcaa ctggcttgtc cgcgaaggcg tctccattca tcccggcctc     60

gccgtgcagg aatggcggca agagggagac ggcgtcctct tcttcgtcgc gtgccgcccc    120

gtggcgcacc gcggccacat gctcgatggc cccatgctca cctgccgcat ctcctttccc    180

cggcctggta tggtgcgggt ggagcagcat cactttttcg gccggatgcc ccgcgggccc    240

catttcccgc ttgagctcaa acctcagccg tttgacgcgg cggagacgga ggacggtgtc    300

gtcctgcgcg ccggcgagat ggaggtgcgc gtgcggctgt ccccatggtc catcgcgttt    360

tacgagaacg gccgctttct caccgagagc ggccctcggt cgaccgcgta cgtcgtcgat    420

cacggccgcc cccacatgcg cggccaattg catctgtccg tgggtgaaaa cgtctatggc    480

cttggcgagc ggtttacggc gttcgtcaag aacggccagt ccctcgacat ctggaaccga    540

gacggcggga cgggatcgga ccaggcgtac aagaacgtac ccttctatct taccaaccgc    600

ggctacggcg tgttcgtgaa ccatcccgag cgcgtgtggt ttgaaatcgg gacggagttc    660

gtgtccaagg tgcagttcag cgtcgagggg gaggcgctcg attacgtggt cattggcggc    720

tgccatccga agggcgtgat cgagcgatac acggcgctca cggggcggcc ggcgctgccg    780

ccgatgtggt cgtttgggct gtggttgtcg acgtcgttca ccaccgacta tgacgaggag    840

acggtcagcc agtttgtcga cggcatggcg tctcgcggca ttccgctgag cgtattccac    900

ttcgactgtt tctggatgaa gccgtttgag tggtgcaact tcgcgtggga caccgcctgc    960

ttccccgatc cggcgggcat gctcgcgcgc ctcaaatccc gcgggttgcg catctgcgtc   1020

tggatcaacc cctacatcgc gcagaaatcg ccgcttttcc gcgaggcgat ggagcgcggc   1080

tacctgctca aacgcccgaa cggcgacgtg tggcagtggg acctgtggca gccgggcatg   1140

ggcatcgtcg acttcacaaa ccccgacgcc cgccgctggt accagtccca cctgcgtcgg   1200

ctgctcgaca tgggcgtcga tgcgttcaaa acggacttcg gcgagcggat tccgacggat   1260

gtggtgtacc acgacggatc ggacccgcaa aagatgcaca acttctacag ctacctgtac   1320

aacgaggctg tgtgggaagt cctccgcgag cggggaggcg gtgaagcatt ggtctttgcg   1380

cgatccgcca ccgctggcgg ccagcgcttc ccggtgcact ggggcggcga ctgccgggcc   1440

acgtacgaat ccatggcgga gacgcttcgc ggtggcctga gcctcgcctt gtccggcttc   1500

ggattctgga gccacgacat cggcgggttt gaggacacag cccccgccca cctgtacaag   1560

cgctggattg cctttgggct cttctcgagc cacagccgcc tgcacggaag cggatcgtac   1620

cgcgtgccgt ggctgttcga cgaggagtcg gtggacgttt tgcgccactt cacgcggtgg   1680

aagctccggc tcatgccata tctttggtcg tgcgccgtcg aggcgcaccg cacgggcgtg   1740

cccatgctgc gccccatgat gctcgaattt ccggacgatc cgacctgcga caccttggac   1800

cgccaatata tgctcggccc gtcgcttctc gtcgcgccgg tgttctcgga gacgggtgag   1860

gtcgtgtact atctcccgga agggcgctgg acgcacctgt tcaccggaga gacgaggcaa   1920

ggcggcagat ggtaccgcga acggtacgat ttcatgagcc tgcctgtgtt cgtgcgcgaa   1980

ggcagcatcc tggccatggg cgcggaaacg gaccggccta accaacccta ccaccgcgag   2040

gtggccatcc acgtctatcc catccggccg gaccatcgca gtgcgtgcac tctgtttgac   2100

gaacagggca acgaattggg cacatggcat gccttctggg atggagacca tctggtcctc   2160

accgcgcaag gtcggagcga ggcatggagc gccgtattgc acggtatcga cgatccggca   2220

aagctcgccg cgcagggcgc ggaatgccgc gtctcacccg agggagtcgt gatcagcccg   2280

caccatccac aggaggcggt gcgggtggca ggttgccggg agcaatggcg ggcggaatga   2340


<210>  59
<211>  2340
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 51

<400>  59
atgaagttca ccgaaggcaa ctggcttgtc cgcgaaggcg tctccattca tcccggcctc     60

gccgtgcagg aatggcggca agagggagac ggcgtcctct tcttcgtcgc gtgccgcccc    120

gtggcgcacc gcggccacat gctcgatggc cccatgctca cctgccgcat ctcctttccc    180

cggcctggta tggtgcgggt ggagcagcat cactttttcg gccggatgcc ccgcgggccc    240

catttcccgc ttgagctcaa acctcagccg tttgacgcgg cggagacgga ggacggtgtc    300

gtcctgcgcg ccggcgagat ggaggtgcgc gtgcggctgt ccccatggtc catcgcgttt    360

tacgagaacg gccgctttct caccgagagc ggccctcggt cgaccgcgta cgtcgtcgat    420

cacggccgcc cccacatgcg cggccaattg catctgtccg tgggtgaaaa cgtctatggc    480

cttggcgagc ggtttacggc gttcgtcaag aacggccagt ccctcgacat ctggaaccga    540

gacggcggga cgggatcgga ccaggcgtac aagaacgtac ccttctatct taccaaccgc    600

ggctacggcg tgttcgtgaa ccatcccgag cgcgtgtggt ttgaaatcgg gacggagttc    660

gtgtccaagg tgcagttcag cgtcgagggg gaggcgctcg attacgtggt cattggcggc    720

tgccatccga agggcgtgat cgagcgatac acggcgctca cggggcggcc ggcgctgccg    780

ccgatgtggt cgtttgggct gtggttgtcg acgtcgttca ccaccgacta tgacgaggag    840

acggtcagcc agtttgtcga cggcatggcg tctcgcggca ttccgctgag cgtattccac    900

ttcgactgtt tctggatgaa gccgtttgag tggtgcaact tcgcgtggga caccgcctgc    960

ttccccgatc cggcgggcat gctcgcgcgc ctcaaatccc gcgggttgcg catctgcgtc   1020

tggatcaacc cctacatcgc gcagaaatcg ccgcttttcc gcgaggcgat ggagcgcggc   1080

tacctgctca aacgcccgaa cggcgacgtg tggcagtggg acctgtggca gccgggcatg   1140

ggcatcgtcg acttcacaaa ccccgacgcc cgccgctggt accagtccca cctgcgtcgg   1200

ctgctcgaca tgggcgtcga tgcgttcaaa acggacttcg gcgagcggat tccgacggat   1260

gtggtgtacc acgacggatc ggacccgcaa aagatgcaca acttctacag ctacctgtac   1320

aacgaggctg tgtgggaagt cctccgcgag cggggaggcg gtgaagcatt ggtctttgcg   1380

cgatccgcca ccgctggcgg ccagcgcttc ccggtgcact ggggcggcga ctgccgggcc   1440

acgtacgaat ccatggcgga gacgcttcgc ggtggcctga gcctcgcctt gtccggcttc   1500

ggattctgga gccacgacat cggcgggttt gaggacacag cccccgccca cctgtacaag   1560

cgctggattg cctttgggct cttctcgagc cacagccgcc tgcacggaag cggatcgtac   1620

cgcgtgccgt ggctgttcga cgaggagtcg gtggacgttt tgcgccactt cacgcggtgg   1680

aagctccggc tcatgccata tctttggtcg tgcgccgtcg aggcgcaccg cacgggcgtg   1740

cccatgctgc gccccatgat gctcgaattt ccggacgatc cgacctgcga caccttggac   1800

cgccaatata tgctcggccc gtcgcttctc gtcgcgccgg tgttctcgga gacgggtgag   1860

gtcgtgtact atctcccgga agggcgctgg acgcacctgt tcaccggaga gacgaggcaa   1920

ggcggcagat ggtaccgcga acggtacgat ttcatgagcc tgcctgtgtt cgtgcgcgaa   1980

ggcagcatcc tggccatggg cgcggaaacg gaccggccta accaacccta ccaccgcgag   2040

gtggccatcc acgtctatcc catccggccg gaccatcgca gtgcgtgcac tctgtttgac   2100

gaacagggca acgaattggg cacatggcat gccttctggg atggagacca tctggtcctc   2160

accgcgcaag gtcggagcga ggcatggagc gccgtattgc acggtatcga cgatccggca   2220

aagctcgccg cgcagggcgc ggaatgccgc gtctcacccg agggagtcgt gatcagcccg   2280

caccatccac aggaggcggt gcgggtggca ggttgccggg agcaatggcg ggcggaatga   2340


<210>  60
<211>  2340
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 51

<400>  60
atgaagttca ccgacggcaa ctggattgtc cgcgaaggcg tctccattca tcccggcctc     60

gccgtgcagg aatggcggca agagggagac ggcgtcctct tcttcgtcgc gtgccgcccc    120

gtggcgcacc gcggccacat gctcgatggc cccatgctca cctgccgcat ctcctttccc    180

cggcctggta tggtgcgggt ggagcagcat cactttttcg gccggatgcc ccgcgggccc    240

catttcccgc ttgagctcaa acctcagccg tttgacgcgg cggagacgga ggacggtgtc    300

gtcctgcgcg ccggcgagat ggaggtgcgc gtgcggctgt ccccatggtc catcgcgttt    360

tacgagaacg gccgctttct caccgagagc ggccctcggt cgaccgcgta cgtcgtcgat    420

cacggccgcc cccacatgcg cggccaattg catctgtccg tgggtgaaaa cgtctatggc    480

cttggcgagc ggtttacggc gttcgtcaag aacggccagt ccctcgacat ctggaaccga    540

gacggcggga cgggatcgga ccaggcgtac aagaacgtac ccttctatct taccaaccgc    600

ggctacggcg tgttcgtgaa ccatcccgag cgcgtgtggt ttgaaatcgg gacggagttc    660

gtgtccaagg tgcagttcag cgtcgagggg gaggcgctcg attacgtggt cattggcggc    720

tgccatccga agggcgtgat cgagcgatac acggcgctca cggggcggcc ggcgctgccg    780

ccgatgtggt cgtttgggct gtggttgtcg acgtcgttca ccaccgacta tgacgaggag    840

acggtcagcc agtttgtcga cggcatggcg tctcgcggca ttccgctgag cgtattccac    900

ttcgactgtt tctggatgaa gccgtttgag tggtgcaact tcgcgtggga caccgcctgc    960

ttccccgatc cggcgggcat gctcgcgcgc ctcaaatccc gcgggttgcg catctgcgtc   1020

tggatcaacc cctacatcgc gcagaaatcg ccgcttttcc gcgaggcgat ggagcgcggc   1080

tacctgctca aacgcccgaa cggcgacgtg tggcagtggg acctgtggca gccgggcatg   1140

ggcatcgtcg acttcacaaa ccccgacgcc cgccgctggt accagtccca cctgcgtcgg   1200

ctgctcgaca tgggcgtcga tgcgttcaaa acggacttcg gcgagcggat tccgacggat   1260

gtggtgtacc acgacggatc ggacccgcaa aagatgcaca acttctacag ctacctgtac   1320

aacgaggctg tgtgggaagt cctccgcgag cggggaggcg gtgaagcatt ggtctttgcg   1380

cgatccgcca ccgctggcgg ccagcgcttc ccggtgcact ggggcggcga ctgccgggcc   1440

acgtacgaat ccatggcgga gacgcttcgc ggtggcctga gcctcgcctt gtccggcttc   1500

ggattctgga gccacgacat cggcgggttt gaggacacag cccccgccca cctgtacaag   1560

cgctggattg cctttgggct cttctcgagc cacagccgcc tgcacggaag cggatcgtac   1620

cgcgtgccgt ggctgttcga cgaggagtcg gtggacgttt tgcgccactt cacgcggtgg   1680

aagctccggc tcatgccata tctttggtcg tgcgccgtcg aggcgcaccg cacgggcgtg   1740

cccatgctgc gccccatgat gctcgaattt ccggacgatc cgacctgcga caccttggac   1800

cgccaatata tgctcggccc gtcgcttctc gtcgcgccgg tgttctcgga gacgggtgag   1860

gtcgtgtact atctcccgga agggcgctgg acgcacctgt tcaccggaga gacgaggcaa   1920

ggcggcagat ggtaccgcga acggtacgat ttcatgagcc tgcctgtgtt cgtgcgcgaa   1980

ggcagcatcc tggccatggg cgcggaaacg gaccggccta accaacccta ccaccgcgag   2040

gtggccatcc acgtctatcc catccggccg gaccatcgca gtgcgtgcac tctgtttgac   2100

gaacagggca acgaattggg cacatggcat gccttctggg atggagacca tctggtcctc   2160

accgcgcaag gtcggagcga ggcatggagc gccgtattgc acggtatcga cgatccggca   2220

aagctcgccg cgcagggcgc ggaatgccgc gtctcacccg agggagtcgt gatcagcccg   2280

caccatccac aggaggcggt gcgggtggca ggttgccggg agcaatggcg ggcggaatga   2340


<210>  61
<211>  2340
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 51

<400>  61
atgaagttca ccgacggcaa ctggcttctc cgcgaaggcg tctccattca tcccggcctc     60

gccgtgcagg aatggcggca agagggagac ggcgtcctct tcttcgtcgc gtgccgcccc    120

gtggcgcacc gcggccacat gctcgatggc cccatgctca cctgccgcat ctcctttccc    180

cggcctggta tggtgcgggt ggagcagcat cactttttcg gccggatgcc ccgcgggccc    240

catttcccgc ttgagctcaa acctcagccg tttgacgcgg cggagacgga ggacggtgtc    300

gtcctgcgcg ccggcgagat ggaggtgcgc gtgcggctgt ccccatggtc catcgcgttt    360

tacgagaacg gccgctttct caccgagagc ggccctcggt cgaccgcgta cgtcgtcgat    420

cacggccgcc cccacatgcg cggccaattg catctgtccg tgggtgaaaa cgtctatggc    480

cttggcgagc ggtttacggc gttcgtcaag aacggccagt ccctcgacat ctggaaccga    540

gacggcggga cgggatcgga ccaggcgtac aagaacgtac ccttctatct taccaaccgc    600

ggctacggcg tgttcgtgaa ccatcccgag cgcgtgtggt ttgaaatcgg gacggagttc    660

gtgtccaagg tgcagttcag cgtcgagggg gaggcgctcg attacgtggt cattggcggc    720

tgccatccga agggcgtgat cgagcgatac acggcgctca cggggcggcc ggcgctgccg    780

ccgatgtggt cgtttgggct gtggttgtcg acgtcgttca ccaccgacta tgacgaggag    840

acggtcagcc agtttgtcga cggcatggcg tctcgcggca ttccgctgag cgtattccac    900

ttcgactgtt tctggatgaa gccgtttgag tggtgcaact tcgcgtggga caccgcctgc    960

ttccccgatc cggcgggcat gctcgcgcgc ctcaaatccc gcgggttgcg catctgcgtc   1020

tggatcaacc cctacatcgc gcagaaatcg ccgcttttcc gcgaggcgat ggagcgcggc   1080

tacctgctca aacgcccgaa cggcgacgtg tggcagtggg acctgtggca gccgggcatg   1140

ggcatcgtcg acttcacaaa ccccgacgcc cgccgctggt accagtccca cctgcgtcgg   1200

ctgctcgaca tgggcgtcga tgcgttcaaa acggacttcg gcgagcggat tccgacggat   1260

gtggtgtacc acgacggatc ggacccgcaa aagatgcaca acttctacag ctacctgtac   1320

aacgaggctg tgtgggaagt cctccgcgag cggggaggcg gtgaagcatt ggtctttgcg   1380

cgatccgcca ccgctggcgg ccagcgcttc ccggtgcact ggggcggcga ctgccgggcc   1440

acgtacgaat ccatggcgga gacgcttcgc ggtggcctga gcctcgcctt gtccggcttc   1500

ggattctgga gccacgacat cggcgggttt gaggacacag cccccgccca cctgtacaag   1560

cgctggattg cctttgggct cttctcgagc cacagccgcc tgcacggaag cggatcgtac   1620

cgcgtgccgt ggctgttcga cgaggagtcg gtggacgttt tgcgccactt cacgcggtgg   1680

aagctccggc tcatgccata tctttggtcg tgcgccgtcg aggcgcaccg cacgggcgtg   1740

cccatgctgc gccccatgat gctcgaattt ccggacgatc cgacctgcga caccttggac   1800

cgccaatata tgctcggccc gtcgcttctc gtcgcgccgg tgttctcgga gacgggtgag   1860

gtcgtgtact atctcccgga agggcgctgg acgcacctgt tcaccggaga gacgaggcaa   1920

ggcggcagat ggtaccgcga acggtacgat ttcatgagcc tgcctgtgtt cgtgcgcgaa   1980

ggcagcatcc tggccatggg cgcggaaacg gaccggccta accaacccta ccaccgcgag   2040

gtggccatcc acgtctatcc catccggccg gaccatcgca gtgcgtgcac tctgtttgac   2100

gaacagggca acgaattggg cacatggcat gccttctggg atggagacca tctggtcctc   2160

accgcgcaag gtcggagcga ggcatggagc gccgtattgc acggtatcga cgatccggca   2220

aagctcgccg cgcagggcgc ggaatgccgc gtctcacccg agggagtcgt gatcagcccg   2280

caccatccac aggaggcggt gcgggtggca ggttgccggg agcaatggcg ggcggaatga   2340


<210>  62
<211>  2340
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 51

<400>  62
atgaagttca ccgacggcaa ctggcttatc cgcgaaggcg tctccattca tcccggcctc     60

gccgtgcagg aatggcggca agagggagac ggcgtcctct tcttcgtcgc gtgccgcccc    120

gtggcgcacc gcggccacat gctcgatggc cccatgctca cctgccgcat ctcctttccc    180

cggcctggta tggtgcgggt ggagcagcat cactttttcg gccggatgcc ccgcgggccc    240

catttcccgc ttgagctcaa acctcagccg tttgacgcgg cggagacgga ggacggtgtc    300

gtcctgcgcg ccggcgagat ggaggtgcgc gtgcggctgt ccccatggtc catcgcgttt    360

tacgagaacg gccgctttct caccgagagc ggccctcggt cgaccgcgta cgtcgtcgat    420

cacggccgcc cccacatgcg cggccaattg catctgtccg tgggtgaaaa cgtctatggc    480

cttggcgagc ggtttacggc gttcgtcaag aacggccagt ccctcgacat ctggaaccga    540

gacggcggga cgggatcgga ccaggcgtac aagaacgtac ccttctatct taccaaccgc    600

ggctacggcg tgttcgtgaa ccatcccgag cgcgtgtggt ttgaaatcgg gacggagttc    660

gtgtccaagg tgcagttcag cgtcgagggg gaggcgctcg attacgtggt cattggcggc    720

tgccatccga agggcgtgat cgagcgatac acggcgctca cggggcggcc ggcgctgccg    780

ccgatgtggt cgtttgggct gtggttgtcg acgtcgttca ccaccgacta tgacgaggag    840

acggtcagcc agtttgtcga cggcatggcg tctcgcggca ttccgctgag cgtattccac    900

ttcgactgtt tctggatgaa gccgtttgag tggtgcaact tcgcgtggga caccgcctgc    960

ttccccgatc cggcgggcat gctcgcgcgc ctcaaatccc gcgggttgcg catctgcgtc   1020

tggatcaacc cctacatcgc gcagaaatcg ccgcttttcc gcgaggcgat ggagcgcggc   1080

tacctgctca aacgcccgaa cggcgacgtg tggcagtggg acctgtggca gccgggcatg   1140

ggcatcgtcg acttcacaaa ccccgacgcc cgccgctggt accagtccca cctgcgtcgg   1200

ctgctcgaca tgggcgtcga tgcgttcaaa acggacttcg gcgagcggat tccgacggat   1260

gtggtgtacc acgacggatc ggacccgcaa aagatgcaca acttctacag ctacctgtac   1320

aacgaggctg tgtgggaagt cctccgcgag cggggaggcg gtgaagcatt ggtctttgcg   1380

cgatccgcca ccgctggcgg ccagcgcttc ccggtgcact ggggcggcga ctgccgggcc   1440

acgtacgaat ccatggcgga gacgcttcgc ggtggcctga gcctcgcctt gtccggcttc   1500

ggattctgga gccacgacat cggcgggttt gaggacacag cccccgccca cctgtacaag   1560

cgctggattg cctttgggct cttctcgagc cacagccgcc tgcacggaag cggatcgtac   1620

cgcgtgccgt ggctgttcga cgaggagtcg gtggacgttt tgcgccactt cacgcggtgg   1680

aagctccggc tcatgccata tctttggtcg tgcgccgtcg aggcgcaccg cacgggcgtg   1740

cccatgctgc gccccatgat gctcgaattt ccggacgatc cgacctgcga caccttggac   1800

cgccaatata tgctcggccc gtcgcttctc gtcgcgccgg tgttctcgga gacgggtgag   1860

gtcgtgtact atctcccgga agggcgctgg acgcacctgt tcaccggaga gacgaggcaa   1920

ggcggcagat ggtaccgcga acggtacgat ttcatgagcc tgcctgtgtt cgtgcgcgaa   1980

ggcagcatcc tggccatggg cgcggaaacg gaccggccta accaacccta ccaccgcgag   2040

gtggccatcc acgtctatcc catccggccg gaccatcgca gtgcgtgcac tctgtttgac   2100

gaacagggca acgaattggg cacatggcat gccttctggg atggagacca tctggtcctc   2160

accgcgcaag gtcggagcga ggcatggagc gccgtattgc acggtatcga cgatccggca   2220

aagctcgccg cgcagggcgc ggaatgccgc gtctcacccg agggagtcgt gatcagcccg   2280

caccatccac aggaggcggt gcgggtggca ggttgccggg agcaatggcg ggcggaatga   2340


<210>  63
<211>  779
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:52 and encoded by SEQ ID NO:58

<400>  63

Met Arg Phe Thr Asp Gly Asn Trp Leu Val Arg Glu Gly Val Ser Ile 
1               5                   10                  15      


His Pro Gly Leu Ala Val Gln Glu Trp Arg Gln Glu Gly Asp Gly Val 
            20                  25                  30          


Leu Phe Phe Val Ala Cys Arg Pro Val Ala His Arg Gly His Met Leu 
        35                  40                  45              


Asp Gly Pro Met Leu Thr Cys Arg Ile Ser Phe Pro Arg Pro Gly Met 
    50                  55                  60                  


Val Arg Val Glu Gln His His Phe Phe Gly Arg Met Pro Arg Gly Pro 
65                  70                  75                  80  


His Phe Pro Leu Glu Leu Lys Pro Gln Pro Phe Asp Ala Ala Glu Thr 
                85                  90                  95      


Glu Asp Gly Val Val Leu Arg Ala Gly Glu Met Glu Val Arg Val Arg 
            100                 105                 110         


Leu Ser Pro Trp Ser Ile Ala Phe Tyr Glu Asn Gly Arg Phe Leu Thr 
        115                 120                 125             


Glu Ser Gly Pro Arg Ser Thr Ala Tyr Val Val Asp His Gly Arg Pro 
    130                 135                 140                 


His Met Arg Gly Gln Leu His Leu Ser Val Gly Glu Asn Val Tyr Gly 
145                 150                 155                 160 


Leu Gly Glu Arg Phe Thr Ala Phe Val Lys Asn Gly Gln Ser Leu Asp 
                165                 170                 175     


Ile Trp Asn Arg Asp Gly Gly Thr Gly Ser Asp Gln Ala Tyr Lys Asn 
            180                 185                 190         


Val Pro Phe Tyr Leu Thr Asn Arg Gly Tyr Gly Val Phe Val Asn His 
        195                 200                 205             


Pro Glu Arg Val Trp Phe Glu Ile Gly Thr Glu Phe Val Ser Lys Val 
    210                 215                 220                 


Gln Phe Ser Val Glu Gly Glu Ala Leu Asp Tyr Val Val Ile Gly Gly 
225                 230                 235                 240 


Cys His Pro Lys Gly Val Ile Glu Arg Tyr Thr Ala Leu Thr Gly Arg 
                245                 250                 255     


Pro Ala Leu Pro Pro Met Trp Ser Phe Gly Leu Trp Leu Ser Thr Ser 
            260                 265                 270         


Phe Thr Thr Asp Tyr Asp Glu Glu Thr Val Ser Gln Phe Val Asp Gly 
        275                 280                 285             


Met Ala Ser Arg Gly Ile Pro Leu Ser Val Phe His Phe Asp Cys Phe 
    290                 295                 300                 


Trp Met Lys Pro Phe Glu Trp Cys Asn Phe Ala Trp Asp Thr Ala Cys 
305                 310                 315                 320 


Phe Pro Asp Pro Ala Gly Met Leu Ala Arg Leu Lys Ser Arg Gly Leu 
                325                 330                 335     


Arg Ile Cys Val Trp Ile Asn Pro Tyr Ile Ala Gln Lys Ser Pro Leu 
            340                 345                 350         


Phe Arg Glu Ala Met Glu Arg Gly Tyr Leu Leu Lys Arg Pro Asn Gly 
        355                 360                 365             


Asp Val Trp Gln Trp Asp Leu Trp Gln Pro Gly Met Gly Ile Val Asp 
    370                 375                 380                 


Phe Thr Asn Pro Asp Ala Arg Arg Trp Tyr Gln Ser His Leu Arg Arg 
385                 390                 395                 400 


Leu Leu Asp Met Gly Val Asp Ala Phe Lys Thr Asp Phe Gly Glu Arg 
                405                 410                 415     


Ile Pro Thr Asp Val Val Tyr His Asp Gly Ser Asp Pro Gln Lys Met 
            420                 425                 430         


His Asn Phe Tyr Ser Tyr Leu Tyr Asn Glu Ala Val Trp Glu Val Leu 
        435                 440                 445             


Arg Glu Arg Gly Gly Gly Glu Ala Leu Val Phe Ala Arg Ser Ala Thr 
    450                 455                 460                 


Ala Gly Gly Gln Arg Phe Pro Val His Trp Gly Gly Asp Cys Arg Ala 
465                 470                 475                 480 


Thr Tyr Glu Ser Met Ala Glu Thr Leu Arg Gly Gly Leu Ser Leu Ala 
                485                 490                 495     


Leu Ser Gly Phe Gly Phe Trp Ser His Asp Ile Gly Gly Phe Glu Asp 
            500                 505                 510         


Thr Ala Pro Ala His Leu Tyr Lys Arg Trp Ile Ala Phe Gly Leu Phe 
        515                 520                 525             


Ser Ser His Ser Arg Leu His Gly Ser Gly Ser Tyr Arg Val Pro Trp 
    530                 535                 540                 


Leu Phe Asp Glu Glu Ser Val Asp Val Leu Arg His Phe Thr Arg Trp 
545                 550                 555                 560 


Lys Leu Arg Leu Met Pro Tyr Leu Trp Ser Cys Ala Val Glu Ala His 
                565                 570                 575     


Arg Thr Gly Val Pro Met Leu Arg Pro Met Met Leu Glu Phe Pro Asp 
            580                 585                 590         


Asp Pro Thr Cys Asp Thr Leu Asp Arg Gln Tyr Met Leu Gly Pro Ser 
        595                 600                 605             


Leu Leu Val Ala Pro Val Phe Ser Glu Thr Gly Glu Val Val Tyr Tyr 
    610                 615                 620                 


Leu Pro Glu Gly Arg Trp Thr His Leu Phe Thr Gly Glu Thr Arg Gln 
625                 630                 635                 640 


Gly Gly Arg Trp Tyr Arg Glu Arg Tyr Asp Phe Met Ser Leu Pro Val 
                645                 650                 655     


Phe Val Arg Glu Gly Ser Ile Leu Ala Met Gly Ala Glu Thr Asp Arg 
            660                 665                 670         


Pro Asn Gln Pro Tyr His Arg Glu Val Ala Ile His Val Tyr Pro Ile 
        675                 680                 685             


Arg Pro Asp His Arg Ser Ala Cys Thr Leu Phe Asp Glu Gln Gly Asn 
    690                 695                 700                 


Glu Leu Gly Thr Trp His Ala Phe Trp Asp Gly Asp His Leu Val Leu 
705                 710                 715                 720 


Thr Ala Gln Gly Arg Ser Glu Ala Trp Ser Ala Val Leu His Gly Ile 
                725                 730                 735     


Asp Asp Pro Ala Lys Leu Ala Ala Gln Gly Ala Glu Cys Arg Val Ser 
            740                 745                 750         


Pro Glu Gly Val Val Ile Ser Pro His His Pro Gln Glu Ala Val Arg 
        755                 760                 765             


Val Ala Gly Cys Arg Glu Gln Trp Arg Ala Glu 
    770                 775                 


<210>  64
<211>  779
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:52 and encoded by SEQ ID NO:59

<400>  64

Met Lys Phe Thr Glu Gly Asn Trp Leu Val Arg Glu Gly Val Ser Ile 
1               5                   10                  15      


His Pro Gly Leu Ala Val Gln Glu Trp Arg Gln Glu Gly Asp Gly Val 
            20                  25                  30          


Leu Phe Phe Val Ala Cys Arg Pro Val Ala His Arg Gly His Met Leu 
        35                  40                  45              


Asp Gly Pro Met Leu Thr Cys Arg Ile Ser Phe Pro Arg Pro Gly Met 
    50                  55                  60                  


Val Arg Val Glu Gln His His Phe Phe Gly Arg Met Pro Arg Gly Pro 
65                  70                  75                  80  


His Phe Pro Leu Glu Leu Lys Pro Gln Pro Phe Asp Ala Ala Glu Thr 
                85                  90                  95      


Glu Asp Gly Val Val Leu Arg Ala Gly Glu Met Glu Val Arg Val Arg 
            100                 105                 110         


Leu Ser Pro Trp Ser Ile Ala Phe Tyr Glu Asn Gly Arg Phe Leu Thr 
        115                 120                 125             


Glu Ser Gly Pro Arg Ser Thr Ala Tyr Val Val Asp His Gly Arg Pro 
    130                 135                 140                 


His Met Arg Gly Gln Leu His Leu Ser Val Gly Glu Asn Val Tyr Gly 
145                 150                 155                 160 


Leu Gly Glu Arg Phe Thr Ala Phe Val Lys Asn Gly Gln Ser Leu Asp 
                165                 170                 175     


Ile Trp Asn Arg Asp Gly Gly Thr Gly Ser Asp Gln Ala Tyr Lys Asn 
            180                 185                 190         


Val Pro Phe Tyr Leu Thr Asn Arg Gly Tyr Gly Val Phe Val Asn His 
        195                 200                 205             


Pro Glu Arg Val Trp Phe Glu Ile Gly Thr Glu Phe Val Ser Lys Val 
    210                 215                 220                 


Gln Phe Ser Val Glu Gly Glu Ala Leu Asp Tyr Val Val Ile Gly Gly 
225                 230                 235                 240 


Cys His Pro Lys Gly Val Ile Glu Arg Tyr Thr Ala Leu Thr Gly Arg 
                245                 250                 255     


Pro Ala Leu Pro Pro Met Trp Ser Phe Gly Leu Trp Leu Ser Thr Ser 
            260                 265                 270         


Phe Thr Thr Asp Tyr Asp Glu Glu Thr Val Ser Gln Phe Val Asp Gly 
        275                 280                 285             


Met Ala Ser Arg Gly Ile Pro Leu Ser Val Phe His Phe Asp Cys Phe 
    290                 295                 300                 


Trp Met Lys Pro Phe Glu Trp Cys Asn Phe Ala Trp Asp Thr Ala Cys 
305                 310                 315                 320 


Phe Pro Asp Pro Ala Gly Met Leu Ala Arg Leu Lys Ser Arg Gly Leu 
                325                 330                 335     


Arg Ile Cys Val Trp Ile Asn Pro Tyr Ile Ala Gln Lys Ser Pro Leu 
            340                 345                 350         


Phe Arg Glu Ala Met Glu Arg Gly Tyr Leu Leu Lys Arg Pro Asn Gly 
        355                 360                 365             


Asp Val Trp Gln Trp Asp Leu Trp Gln Pro Gly Met Gly Ile Val Asp 
    370                 375                 380                 


Phe Thr Asn Pro Asp Ala Arg Arg Trp Tyr Gln Ser His Leu Arg Arg 
385                 390                 395                 400 


Leu Leu Asp Met Gly Val Asp Ala Phe Lys Thr Asp Phe Gly Glu Arg 
                405                 410                 415     


Ile Pro Thr Asp Val Val Tyr His Asp Gly Ser Asp Pro Gln Lys Met 
            420                 425                 430         


His Asn Phe Tyr Ser Tyr Leu Tyr Asn Glu Ala Val Trp Glu Val Leu 
        435                 440                 445             


Arg Glu Arg Gly Gly Gly Glu Ala Leu Val Phe Ala Arg Ser Ala Thr 
    450                 455                 460                 


Ala Gly Gly Gln Arg Phe Pro Val His Trp Gly Gly Asp Cys Arg Ala 
465                 470                 475                 480 


Thr Tyr Glu Ser Met Ala Glu Thr Leu Arg Gly Gly Leu Ser Leu Ala 
                485                 490                 495     


Leu Ser Gly Phe Gly Phe Trp Ser His Asp Ile Gly Gly Phe Glu Asp 
            500                 505                 510         


Thr Ala Pro Ala His Leu Tyr Lys Arg Trp Ile Ala Phe Gly Leu Phe 
        515                 520                 525             


Ser Ser His Ser Arg Leu His Gly Ser Gly Ser Tyr Arg Val Pro Trp 
    530                 535                 540                 


Leu Phe Asp Glu Glu Ser Val Asp Val Leu Arg His Phe Thr Arg Trp 
545                 550                 555                 560 


Lys Leu Arg Leu Met Pro Tyr Leu Trp Ser Cys Ala Val Glu Ala His 
                565                 570                 575     


Arg Thr Gly Val Pro Met Leu Arg Pro Met Met Leu Glu Phe Pro Asp 
            580                 585                 590         


Asp Pro Thr Cys Asp Thr Leu Asp Arg Gln Tyr Met Leu Gly Pro Ser 
        595                 600                 605             


Leu Leu Val Ala Pro Val Phe Ser Glu Thr Gly Glu Val Val Tyr Tyr 
    610                 615                 620                 


Leu Pro Glu Gly Arg Trp Thr His Leu Phe Thr Gly Glu Thr Arg Gln 
625                 630                 635                 640 


Gly Gly Arg Trp Tyr Arg Glu Arg Tyr Asp Phe Met Ser Leu Pro Val 
                645                 650                 655     


Phe Val Arg Glu Gly Ser Ile Leu Ala Met Gly Ala Glu Thr Asp Arg 
            660                 665                 670         


Pro Asn Gln Pro Tyr His Arg Glu Val Ala Ile His Val Tyr Pro Ile 
        675                 680                 685             


Arg Pro Asp His Arg Ser Ala Cys Thr Leu Phe Asp Glu Gln Gly Asn 
    690                 695                 700                 


Glu Leu Gly Thr Trp His Ala Phe Trp Asp Gly Asp His Leu Val Leu 
705                 710                 715                 720 


Thr Ala Gln Gly Arg Ser Glu Ala Trp Ser Ala Val Leu His Gly Ile 
                725                 730                 735     


Asp Asp Pro Ala Lys Leu Ala Ala Gln Gly Ala Glu Cys Arg Val Ser 
            740                 745                 750         


Pro Glu Gly Val Val Ile Ser Pro His His Pro Gln Glu Ala Val Arg 
        755                 760                 765             


Val Ala Gly Cys Arg Glu Gln Trp Arg Ala Glu 
    770                 775                 


<210>  65
<211>  779
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:52 and encoded by SEQ ID NO:60

<400>  65

Met Lys Phe Thr Asp Gly Asn Trp Ile Val Arg Glu Gly Val Ser Ile 
1               5                   10                  15      


His Pro Gly Leu Ala Val Gln Glu Trp Arg Gln Glu Gly Asp Gly Val 
            20                  25                  30          


Leu Phe Phe Val Ala Cys Arg Pro Val Ala His Arg Gly His Met Leu 
        35                  40                  45              


Asp Gly Pro Met Leu Thr Cys Arg Ile Ser Phe Pro Arg Pro Gly Met 
    50                  55                  60                  


Val Arg Val Glu Gln His His Phe Phe Gly Arg Met Pro Arg Gly Pro 
65                  70                  75                  80  


His Phe Pro Leu Glu Leu Lys Pro Gln Pro Phe Asp Ala Ala Glu Thr 
                85                  90                  95      


Glu Asp Gly Val Val Leu Arg Ala Gly Glu Met Glu Val Arg Val Arg 
            100                 105                 110         


Leu Ser Pro Trp Ser Ile Ala Phe Tyr Glu Asn Gly Arg Phe Leu Thr 
        115                 120                 125             


Glu Ser Gly Pro Arg Ser Thr Ala Tyr Val Val Asp His Gly Arg Pro 
    130                 135                 140                 


His Met Arg Gly Gln Leu His Leu Ser Val Gly Glu Asn Val Tyr Gly 
145                 150                 155                 160 


Leu Gly Glu Arg Phe Thr Ala Phe Val Lys Asn Gly Gln Ser Leu Asp 
                165                 170                 175     


Ile Trp Asn Arg Asp Gly Gly Thr Gly Ser Asp Gln Ala Tyr Lys Asn 
            180                 185                 190         


Val Pro Phe Tyr Leu Thr Asn Arg Gly Tyr Gly Val Phe Val Asn His 
        195                 200                 205             


Pro Glu Arg Val Trp Phe Glu Ile Gly Thr Glu Phe Val Ser Lys Val 
    210                 215                 220                 


Gln Phe Ser Val Glu Gly Glu Ala Leu Asp Tyr Val Val Ile Gly Gly 
225                 230                 235                 240 


Cys His Pro Lys Gly Val Ile Glu Arg Tyr Thr Ala Leu Thr Gly Arg 
                245                 250                 255     


Pro Ala Leu Pro Pro Met Trp Ser Phe Gly Leu Trp Leu Ser Thr Ser 
            260                 265                 270         


Phe Thr Thr Asp Tyr Asp Glu Glu Thr Val Ser Gln Phe Val Asp Gly 
        275                 280                 285             


Met Ala Ser Arg Gly Ile Pro Leu Ser Val Phe His Phe Asp Cys Phe 
    290                 295                 300                 


Trp Met Lys Pro Phe Glu Trp Cys Asn Phe Ala Trp Asp Thr Ala Cys 
305                 310                 315                 320 


Phe Pro Asp Pro Ala Gly Met Leu Ala Arg Leu Lys Ser Arg Gly Leu 
                325                 330                 335     


Arg Ile Cys Val Trp Ile Asn Pro Tyr Ile Ala Gln Lys Ser Pro Leu 
            340                 345                 350         


Phe Arg Glu Ala Met Glu Arg Gly Tyr Leu Leu Lys Arg Pro Asn Gly 
        355                 360                 365             


Asp Val Trp Gln Trp Asp Leu Trp Gln Pro Gly Met Gly Ile Val Asp 
    370                 375                 380                 


Phe Thr Asn Pro Asp Ala Arg Arg Trp Tyr Gln Ser His Leu Arg Arg 
385                 390                 395                 400 


Leu Leu Asp Met Gly Val Asp Ala Phe Lys Thr Asp Phe Gly Glu Arg 
                405                 410                 415     


Ile Pro Thr Asp Val Val Tyr His Asp Gly Ser Asp Pro Gln Lys Met 
            420                 425                 430         


His Asn Phe Tyr Ser Tyr Leu Tyr Asn Glu Ala Val Trp Glu Val Leu 
        435                 440                 445             


Arg Glu Arg Gly Gly Gly Glu Ala Leu Val Phe Ala Arg Ser Ala Thr 
    450                 455                 460                 


Ala Gly Gly Gln Arg Phe Pro Val His Trp Gly Gly Asp Cys Arg Ala 
465                 470                 475                 480 


Thr Tyr Glu Ser Met Ala Glu Thr Leu Arg Gly Gly Leu Ser Leu Ala 
                485                 490                 495     


Leu Ser Gly Phe Gly Phe Trp Ser His Asp Ile Gly Gly Phe Glu Asp 
            500                 505                 510         


Thr Ala Pro Ala His Leu Tyr Lys Arg Trp Ile Ala Phe Gly Leu Phe 
        515                 520                 525             


Ser Ser His Ser Arg Leu His Gly Ser Gly Ser Tyr Arg Val Pro Trp 
    530                 535                 540                 


Leu Phe Asp Glu Glu Ser Val Asp Val Leu Arg His Phe Thr Arg Trp 
545                 550                 555                 560 


Lys Leu Arg Leu Met Pro Tyr Leu Trp Ser Cys Ala Val Glu Ala His 
                565                 570                 575     


Arg Thr Gly Val Pro Met Leu Arg Pro Met Met Leu Glu Phe Pro Asp 
            580                 585                 590         


Asp Pro Thr Cys Asp Thr Leu Asp Arg Gln Tyr Met Leu Gly Pro Ser 
        595                 600                 605             


Leu Leu Val Ala Pro Val Phe Ser Glu Thr Gly Glu Val Val Tyr Tyr 
    610                 615                 620                 


Leu Pro Glu Gly Arg Trp Thr His Leu Phe Thr Gly Glu Thr Arg Gln 
625                 630                 635                 640 


Gly Gly Arg Trp Tyr Arg Glu Arg Tyr Asp Phe Met Ser Leu Pro Val 
                645                 650                 655     


Phe Val Arg Glu Gly Ser Ile Leu Ala Met Gly Ala Glu Thr Asp Arg 
            660                 665                 670         


Pro Asn Gln Pro Tyr His Arg Glu Val Ala Ile His Val Tyr Pro Ile 
        675                 680                 685             


Arg Pro Asp His Arg Ser Ala Cys Thr Leu Phe Asp Glu Gln Gly Asn 
    690                 695                 700                 


Glu Leu Gly Thr Trp His Ala Phe Trp Asp Gly Asp His Leu Val Leu 
705                 710                 715                 720 


Thr Ala Gln Gly Arg Ser Glu Ala Trp Ser Ala Val Leu His Gly Ile 
                725                 730                 735     


Asp Asp Pro Ala Lys Leu Ala Ala Gln Gly Ala Glu Cys Arg Val Ser 
            740                 745                 750         


Pro Glu Gly Val Val Ile Ser Pro His His Pro Gln Glu Ala Val Arg 
        755                 760                 765             


Val Ala Gly Cys Arg Glu Gln Trp Arg Ala Glu 
    770                 775                 


<210>  66
<211>  779
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:52 and encoded by SEQ ID NO:61

<400>  66

Met Lys Phe Thr Asp Gly Asn Trp Leu Leu Arg Glu Gly Val Ser Ile 
1               5                   10                  15      


His Pro Gly Leu Ala Val Gln Glu Trp Arg Gln Glu Gly Asp Gly Val 
            20                  25                  30          


Leu Phe Phe Val Ala Cys Arg Pro Val Ala His Arg Gly His Met Leu 
        35                  40                  45              


Asp Gly Pro Met Leu Thr Cys Arg Ile Ser Phe Pro Arg Pro Gly Met 
    50                  55                  60                  


Val Arg Val Glu Gln His His Phe Phe Gly Arg Met Pro Arg Gly Pro 
65                  70                  75                  80  


His Phe Pro Leu Glu Leu Lys Pro Gln Pro Phe Asp Ala Ala Glu Thr 
                85                  90                  95      


Glu Asp Gly Val Val Leu Arg Ala Gly Glu Met Glu Val Arg Val Arg 
            100                 105                 110         


Leu Ser Pro Trp Ser Ile Ala Phe Tyr Glu Asn Gly Arg Phe Leu Thr 
        115                 120                 125             


Glu Ser Gly Pro Arg Ser Thr Ala Tyr Val Val Asp His Gly Arg Pro 
    130                 135                 140                 


His Met Arg Gly Gln Leu His Leu Ser Val Gly Glu Asn Val Tyr Gly 
145                 150                 155                 160 


Leu Gly Glu Arg Phe Thr Ala Phe Val Lys Asn Gly Gln Ser Leu Asp 
                165                 170                 175     


Ile Trp Asn Arg Asp Gly Gly Thr Gly Ser Asp Gln Ala Tyr Lys Asn 
            180                 185                 190         


Val Pro Phe Tyr Leu Thr Asn Arg Gly Tyr Gly Val Phe Val Asn His 
        195                 200                 205             


Pro Glu Arg Val Trp Phe Glu Ile Gly Thr Glu Phe Val Ser Lys Val 
    210                 215                 220                 


Gln Phe Ser Val Glu Gly Glu Ala Leu Asp Tyr Val Val Ile Gly Gly 
225                 230                 235                 240 


Cys His Pro Lys Gly Val Ile Glu Arg Tyr Thr Ala Leu Thr Gly Arg 
                245                 250                 255     


Pro Ala Leu Pro Pro Met Trp Ser Phe Gly Leu Trp Leu Ser Thr Ser 
            260                 265                 270         


Phe Thr Thr Asp Tyr Asp Glu Glu Thr Val Ser Gln Phe Val Asp Gly 
        275                 280                 285             


Met Ala Ser Arg Gly Ile Pro Leu Ser Val Phe His Phe Asp Cys Phe 
    290                 295                 300                 


Trp Met Lys Pro Phe Glu Trp Cys Asn Phe Ala Trp Asp Thr Ala Cys 
305                 310                 315                 320 


Phe Pro Asp Pro Ala Gly Met Leu Ala Arg Leu Lys Ser Arg Gly Leu 
                325                 330                 335     


Arg Ile Cys Val Trp Ile Asn Pro Tyr Ile Ala Gln Lys Ser Pro Leu 
            340                 345                 350         


Phe Arg Glu Ala Met Glu Arg Gly Tyr Leu Leu Lys Arg Pro Asn Gly 
        355                 360                 365             


Asp Val Trp Gln Trp Asp Leu Trp Gln Pro Gly Met Gly Ile Val Asp 
    370                 375                 380                 


Phe Thr Asn Pro Asp Ala Arg Arg Trp Tyr Gln Ser His Leu Arg Arg 
385                 390                 395                 400 


Leu Leu Asp Met Gly Val Asp Ala Phe Lys Thr Asp Phe Gly Glu Arg 
                405                 410                 415     


Ile Pro Thr Asp Val Val Tyr His Asp Gly Ser Asp Pro Gln Lys Met 
            420                 425                 430         


His Asn Phe Tyr Ser Tyr Leu Tyr Asn Glu Ala Val Trp Glu Val Leu 
        435                 440                 445             


Arg Glu Arg Gly Gly Gly Glu Ala Leu Val Phe Ala Arg Ser Ala Thr 
    450                 455                 460                 


Ala Gly Gly Gln Arg Phe Pro Val His Trp Gly Gly Asp Cys Arg Ala 
465                 470                 475                 480 


Thr Tyr Glu Ser Met Ala Glu Thr Leu Arg Gly Gly Leu Ser Leu Ala 
                485                 490                 495     


Leu Ser Gly Phe Gly Phe Trp Ser His Asp Ile Gly Gly Phe Glu Asp 
            500                 505                 510         


Thr Ala Pro Ala His Leu Tyr Lys Arg Trp Ile Ala Phe Gly Leu Phe 
        515                 520                 525             


Ser Ser His Ser Arg Leu His Gly Ser Gly Ser Tyr Arg Val Pro Trp 
    530                 535                 540                 


Leu Phe Asp Glu Glu Ser Val Asp Val Leu Arg His Phe Thr Arg Trp 
545                 550                 555                 560 


Lys Leu Arg Leu Met Pro Tyr Leu Trp Ser Cys Ala Val Glu Ala His 
                565                 570                 575     


Arg Thr Gly Val Pro Met Leu Arg Pro Met Met Leu Glu Phe Pro Asp 
            580                 585                 590         


Asp Pro Thr Cys Asp Thr Leu Asp Arg Gln Tyr Met Leu Gly Pro Ser 
        595                 600                 605             


Leu Leu Val Ala Pro Val Phe Ser Glu Thr Gly Glu Val Val Tyr Tyr 
    610                 615                 620                 


Leu Pro Glu Gly Arg Trp Thr His Leu Phe Thr Gly Glu Thr Arg Gln 
625                 630                 635                 640 


Gly Gly Arg Trp Tyr Arg Glu Arg Tyr Asp Phe Met Ser Leu Pro Val 
                645                 650                 655     


Phe Val Arg Glu Gly Ser Ile Leu Ala Met Gly Ala Glu Thr Asp Arg 
            660                 665                 670         


Pro Asn Gln Pro Tyr His Arg Glu Val Ala Ile His Val Tyr Pro Ile 
        675                 680                 685             


Arg Pro Asp His Arg Ser Ala Cys Thr Leu Phe Asp Glu Gln Gly Asn 
    690                 695                 700                 


Glu Leu Gly Thr Trp His Ala Phe Trp Asp Gly Asp His Leu Val Leu 
705                 710                 715                 720 


Thr Ala Gln Gly Arg Ser Glu Ala Trp Ser Ala Val Leu His Gly Ile 
                725                 730                 735     


Asp Asp Pro Ala Lys Leu Ala Ala Gln Gly Ala Glu Cys Arg Val Ser 
            740                 745                 750         


Pro Glu Gly Val Val Ile Ser Pro His His Pro Gln Glu Ala Val Arg 
        755                 760                 765             


Val Ala Gly Cys Arg Glu Gln Trp Arg Ala Glu 
    770                 775                 


<210>  67
<211>  779
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:52 and encoded by SEQ ID NO:62

<400>  67

Met Lys Phe Thr Asp Gly Asn Trp Leu Ile Arg Glu Gly Val Ser Ile 
1               5                   10                  15      


His Pro Gly Leu Ala Val Gln Glu Trp Arg Gln Glu Gly Asp Gly Val 
            20                  25                  30          


Leu Phe Phe Val Ala Cys Arg Pro Val Ala His Arg Gly His Met Leu 
        35                  40                  45              


Asp Gly Pro Met Leu Thr Cys Arg Ile Ser Phe Pro Arg Pro Gly Met 
    50                  55                  60                  


Val Arg Val Glu Gln His His Phe Phe Gly Arg Met Pro Arg Gly Pro 
65                  70                  75                  80  


His Phe Pro Leu Glu Leu Lys Pro Gln Pro Phe Asp Ala Ala Glu Thr 
                85                  90                  95      


Glu Asp Gly Val Val Leu Arg Ala Gly Glu Met Glu Val Arg Val Arg 
            100                 105                 110         


Leu Ser Pro Trp Ser Ile Ala Phe Tyr Glu Asn Gly Arg Phe Leu Thr 
        115                 120                 125             


Glu Ser Gly Pro Arg Ser Thr Ala Tyr Val Val Asp His Gly Arg Pro 
    130                 135                 140                 


His Met Arg Gly Gln Leu His Leu Ser Val Gly Glu Asn Val Tyr Gly 
145                 150                 155                 160 


Leu Gly Glu Arg Phe Thr Ala Phe Val Lys Asn Gly Gln Ser Leu Asp 
                165                 170                 175     


Ile Trp Asn Arg Asp Gly Gly Thr Gly Ser Asp Gln Ala Tyr Lys Asn 
            180                 185                 190         


Val Pro Phe Tyr Leu Thr Asn Arg Gly Tyr Gly Val Phe Val Asn His 
        195                 200                 205             


Pro Glu Arg Val Trp Phe Glu Ile Gly Thr Glu Phe Val Ser Lys Val 
    210                 215                 220                 


Gln Phe Ser Val Glu Gly Glu Ala Leu Asp Tyr Val Val Ile Gly Gly 
225                 230                 235                 240 


Cys His Pro Lys Gly Val Ile Glu Arg Tyr Thr Ala Leu Thr Gly Arg 
                245                 250                 255     


Pro Ala Leu Pro Pro Met Trp Ser Phe Gly Leu Trp Leu Ser Thr Ser 
            260                 265                 270         


Phe Thr Thr Asp Tyr Asp Glu Glu Thr Val Ser Gln Phe Val Asp Gly 
        275                 280                 285             


Met Ala Ser Arg Gly Ile Pro Leu Ser Val Phe His Phe Asp Cys Phe 
    290                 295                 300                 


Trp Met Lys Pro Phe Glu Trp Cys Asn Phe Ala Trp Asp Thr Ala Cys 
305                 310                 315                 320 


Phe Pro Asp Pro Ala Gly Met Leu Ala Arg Leu Lys Ser Arg Gly Leu 
                325                 330                 335     


Arg Ile Cys Val Trp Ile Asn Pro Tyr Ile Ala Gln Lys Ser Pro Leu 
            340                 345                 350         


Phe Arg Glu Ala Met Glu Arg Gly Tyr Leu Leu Lys Arg Pro Asn Gly 
        355                 360                 365             


Asp Val Trp Gln Trp Asp Leu Trp Gln Pro Gly Met Gly Ile Val Asp 
    370                 375                 380                 


Phe Thr Asn Pro Asp Ala Arg Arg Trp Tyr Gln Ser His Leu Arg Arg 
385                 390                 395                 400 


Leu Leu Asp Met Gly Val Asp Ala Phe Lys Thr Asp Phe Gly Glu Arg 
                405                 410                 415     


Ile Pro Thr Asp Val Val Tyr His Asp Gly Ser Asp Pro Gln Lys Met 
            420                 425                 430         


His Asn Phe Tyr Ser Tyr Leu Tyr Asn Glu Ala Val Trp Glu Val Leu 
        435                 440                 445             


Arg Glu Arg Gly Gly Gly Glu Ala Leu Val Phe Ala Arg Ser Ala Thr 
    450                 455                 460                 


Ala Gly Gly Gln Arg Phe Pro Val His Trp Gly Gly Asp Cys Arg Ala 
465                 470                 475                 480 


Thr Tyr Glu Ser Met Ala Glu Thr Leu Arg Gly Gly Leu Ser Leu Ala 
                485                 490                 495     


Leu Ser Gly Phe Gly Phe Trp Ser His Asp Ile Gly Gly Phe Glu Asp 
            500                 505                 510         


Thr Ala Pro Ala His Leu Tyr Lys Arg Trp Ile Ala Phe Gly Leu Phe 
        515                 520                 525             


Ser Ser His Ser Arg Leu His Gly Ser Gly Ser Tyr Arg Val Pro Trp 
    530                 535                 540                 


Leu Phe Asp Glu Glu Ser Val Asp Val Leu Arg His Phe Thr Arg Trp 
545                 550                 555                 560 


Lys Leu Arg Leu Met Pro Tyr Leu Trp Ser Cys Ala Val Glu Ala His 
                565                 570                 575     


Arg Thr Gly Val Pro Met Leu Arg Pro Met Met Leu Glu Phe Pro Asp 
            580                 585                 590         


Asp Pro Thr Cys Asp Thr Leu Asp Arg Gln Tyr Met Leu Gly Pro Ser 
        595                 600                 605             


Leu Leu Val Ala Pro Val Phe Ser Glu Thr Gly Glu Val Val Tyr Tyr 
    610                 615                 620                 


Leu Pro Glu Gly Arg Trp Thr His Leu Phe Thr Gly Glu Thr Arg Gln 
625                 630                 635                 640 


Gly Gly Arg Trp Tyr Arg Glu Arg Tyr Asp Phe Met Ser Leu Pro Val 
                645                 650                 655     


Phe Val Arg Glu Gly Ser Ile Leu Ala Met Gly Ala Glu Thr Asp Arg 
            660                 665                 670         


Pro Asn Gln Pro Tyr His Arg Glu Val Ala Ile His Val Tyr Pro Ile 
        675                 680                 685             


Arg Pro Asp His Arg Ser Ala Cys Thr Leu Phe Asp Glu Gln Gly Asn 
    690                 695                 700                 


Glu Leu Gly Thr Trp His Ala Phe Trp Asp Gly Asp His Leu Val Leu 
705                 710                 715                 720 


Thr Ala Gln Gly Arg Ser Glu Ala Trp Ser Ala Val Leu His Gly Ile 
                725                 730                 735     


Asp Asp Pro Ala Lys Leu Ala Ala Gln Gly Ala Glu Cys Arg Val Ser 
            740                 745                 750         


Pro Glu Gly Val Val Ile Ser Pro His His Pro Gln Glu Ala Val Arg 
        755                 760                 765             


Val Ala Gly Cys Arg Glu Gln Trp Arg Ala Glu 
    770                 775                 


<210>  68
<211>  1506
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  68
atgtccaacc tgaaagcgcg catgaccatc gacccggcgt accgcctcgc ggagaccgac     60

cctcgcatct acgggtcctt cattgaacac ctcggccgcg ccgtctacgg cggcatctac    120

gatccgagcc atcccaccgc ggatgaggac ggattccgtc aggacgtgat cgatctcgtc    180

aaggagctca acgtccccat cgtccgctat ccaggcggca atttcgtctc gggctaccgt    240

tgggaagacg gcgtggggcc tgtggaacag cgccccgttc agctcgatct cgcctggcgc    300

agcctggagc cgaatcgcgt gggcctcaat gaattcgcac gctgggcgaa gaaggcgaac    360

agccaggtca tgatggccgt caacctcggc acccgcggca tcgaagaggc caagcagatt    420

gtcgaatatt gcaatcaccc cggaggaagc tactggagcg acctccgccg caagcacggt    480

atcgagcagc cgcacggcat ccgcgtctgg tgcctcggca acgagatgga cgggccttgg    540

cagatcggcc acaagacggc ggacgaatac ggccgcctcg cgcaggaggc cgccaaggtc    600

atgaagtggg tcgatccgtc catcgaactc gtcgcgtgcg gaagctccgg gtccaaaatg    660

gccacgttcc ccgattggga gcggattgtc ctcgagcacg cttacgacga ggtggactac    720

ctgtcgctgc acacgtacta cggcaaccgc gacggggatc tcgccaactt cctggcgtgt    780

tcgctggata tggacgcgtt cattcgcgcc gtcgtggcga catgcgactt cgttcgcgcg    840

aaaaagcgct ccaacaagac catctatctc tcgttcgacg aatggaacgt gtggttccac    900

tcgaacgagg cggacaaaca ggtcgagccg tggcaggtgg ggccgccgct cctcgaagac    960

gtgtacacca tggaagacgc gctcgtggtg ggctgcatgc tcatcacgct gctgaagcac   1020

gccgatcgcg tccggattgc gtgcctcgcg cagcttgtca acgtgattgc gcccatcatg   1080

acggaaaacg gcggcccgag ctggcggcag accatcttct atccgttcgc tcacgcctcg   1140

aacctcgcgc acggcgtggt gttgtatgcg ccagtggagt cgccgaaata cgacagcaag   1200

gacttcacgg acgtgccata cctcgaggcg gtgccggtgt ggaacgaggc ggcgggcgag   1260

atggtcctcc tggcggtgaa ccgcgccgag gagccgctcg cgctcgacgt ggacctgcgc   1320

ggtttcccca acgcccggtc cgaagagcac atcgtgctca cgcatccgaa tatgaaagcg   1380

gtcaatacga aagaacgtcc gaacgaggtt gtcccccaaa agcggtccat cggcgccgtg   1440

gacgcggggc gacttgcggt cgaacttcca gcgctgtcgt ggaacgtgat tcgcattcgc   1500

gtctga                                                              1506


<210>  69
<211>  501
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  69

Met Ser Asn Leu Lys Ala Arg Met Thr Ile Asp Pro Ala Tyr Arg Leu 
1               5                   10                  15      


Ala Glu Thr Asp Pro Arg Ile Tyr Gly Ser Phe Ile Glu His Leu Gly 
            20                  25                  30          


Arg Ala Val Tyr Gly Gly Ile Tyr Asp Pro Ser His Pro Thr Ala Asp 
        35                  40                  45              


Glu Asp Gly Phe Arg Gln Asp Val Ile Asp Leu Val Lys Glu Leu Asn 
    50                  55                  60                  


Val Pro Ile Val Arg Tyr Pro Gly Gly Asn Phe Val Ser Gly Tyr Arg 
65                  70                  75                  80  


Trp Glu Asp Gly Val Gly Pro Val Glu Gln Arg Pro Val Gln Leu Asp 
                85                  90                  95      


Leu Ala Trp Arg Ser Leu Glu Pro Asn Arg Val Gly Leu Asn Glu Phe 
            100                 105                 110         


Ala Arg Trp Ala Lys Lys Ala Asn Ser Gln Val Met Met Ala Val Asn 
        115                 120                 125             


Leu Gly Thr Arg Gly Ile Glu Glu Ala Lys Gln Ile Val Glu Tyr Cys 
    130                 135                 140                 


Asn His Pro Gly Gly Ser Tyr Trp Ser Asp Leu Arg Arg Lys His Gly 
145                 150                 155                 160 


Ile Glu Gln Pro His Gly Ile Arg Val Trp Cys Leu Gly Asn Glu Met 
                165                 170                 175     


Asp Gly Pro Trp Gln Ile Gly His Lys Thr Ala Asp Glu Tyr Gly Arg 
            180                 185                 190         


Leu Ala Gln Glu Ala Ala Lys Val Met Lys Trp Val Asp Pro Ser Ile 
        195                 200                 205             


Glu Leu Val Ala Cys Gly Ser Ser Gly Ser Lys Met Ala Thr Phe Pro 
    210                 215                 220                 


Asp Trp Glu Arg Ile Val Leu Glu His Ala Tyr Asp Glu Val Asp Tyr 
225                 230                 235                 240 


Leu Ser Leu His Thr Tyr Tyr Gly Asn Arg Asp Gly Asp Leu Ala Asn 
                245                 250                 255     


Phe Leu Ala Cys Ser Leu Asp Met Asp Ala Phe Ile Arg Ala Val Val 
            260                 265                 270         


Ala Thr Cys Asp Phe Val Arg Ala Lys Lys Arg Ser Asn Lys Thr Ile 
        275                 280                 285             


Tyr Leu Ser Phe Asp Glu Trp Asn Val Trp Phe His Ser Asn Glu Ala 
    290                 295                 300                 


Asp Lys Gln Val Glu Pro Trp Gln Val Gly Pro Pro Leu Leu Glu Asp 
305                 310                 315                 320 


Val Tyr Thr Met Glu Asp Ala Leu Val Val Gly Cys Met Leu Ile Thr 
                325                 330                 335     


Leu Leu Lys His Ala Asp Arg Val Arg Ile Ala Cys Leu Ala Gln Leu 
            340                 345                 350         


Val Asn Val Ile Ala Pro Ile Met Thr Glu Asn Gly Gly Pro Ser Trp 
        355                 360                 365             


Arg Gln Thr Ile Phe Tyr Pro Phe Ala His Ala Ser Asn Leu Ala His 
    370                 375                 380                 


Gly Val Val Leu Tyr Ala Pro Val Glu Ser Pro Lys Tyr Asp Ser Lys 
385                 390                 395                 400 


Asp Phe Thr Asp Val Pro Tyr Leu Glu Ala Val Pro Val Trp Asn Glu 
                405                 410                 415     


Ala Ala Gly Glu Met Val Leu Leu Ala Val Asn Arg Ala Glu Glu Pro 
            420                 425                 430         


Leu Ala Leu Asp Val Asp Leu Arg Gly Phe Pro Asn Ala Arg Ser Glu 
        435                 440                 445             


Glu His Ile Val Leu Thr His Pro Asn Met Lys Ala Val Asn Thr Lys 
    450                 455                 460                 


Glu Arg Pro Asn Glu Val Val Pro Gln Lys Arg Ser Ile Gly Ala Val 
465                 470                 475                 480 


Asp Ala Gly Arg Leu Ala Val Glu Leu Pro Ala Leu Ser Trp Asn Val 
                485                 490                 495     


Ile Arg Ile Arg Val 
            500     


<210>  70
<211>  500
<212>  PRT
<213>  Bacillus subtilis 

<400>  70

Met Lys Lys Ala Arg Met Ile Val Asp Lys Glu Tyr Lys Ile Gly Glu 
1               5                   10                  15      


Val Asp Lys Arg Ile Tyr Gly Ser Phe Ile Glu His Met Gly Arg Ala 
            20                  25                  30          


Val Tyr Glu Gly Ile Tyr Glu Pro Asp His Pro Glu Ala Asp Glu Asp 
        35                  40                  45              


Gly Phe Arg Lys Asp Val Gln Ser Leu Ile Lys Glu Leu Gln Val Pro 
    50                  55                  60                  


Ile Ile Arg Tyr Pro Gly Gly Asn Phe Leu Ser Gly Tyr Asn Trp Glu 
65                  70                  75                  80  


Asp Gly Val Gly Pro Val Glu Asn Arg Pro Arg Arg Leu Asp Leu Ala 
                85                  90                  95      


Trp Gln Thr Thr Glu Thr Asn Glu Val Gly Thr Asn Glu Phe Leu Ser 
            100                 105                 110         


Trp Pro Lys Lys Val Asn Thr Glu Val Asn Met Ala Val Asn Leu Gly 
        115                 120                 125             


Thr Arg Gly Ile Asp Ala Ala Arg Asn Leu Val Glu Tyr Cys Asn His 
    130                 135                 140                 


Pro Lys Gly Ser Tyr Trp Ser Asp Leu Arg Arg Ser His Gly Tyr Glu 
145                 150                 155                 160 


Gln Pro Tyr Gly Ile Lys Thr Trp Cys Leu Gly Asn Glu Met Asp Gly 
                165                 170                 175     


Pro Trp Gln Ile Gly His Lys Thr Ala Asp Glu Tyr Gly Arg Leu Ala 
            180                 185                 190         


Ala Glu Thr Ala Lys Val Met Lys Trp Val Asp Pro Ser Ile Glu Leu 
        195                 200                 205             


Val Ala Cys Gly Ser Ser Asn Ser Gly Met Pro Thr Phe Ile Asp Trp 
    210                 215                 220                 


Glu Ala Lys Val Leu Glu His Thr Tyr Glu His Val Asp Tyr Ile Ser 
225                 230                 235                 240 


Leu His Thr Tyr Tyr Gly Asn Arg Asp Asn Asn Leu Pro Asn Tyr Leu 
                245                 250                 255     


Ala Arg Ser Met Asp Leu Asp His Phe Ile Lys Ser Val Ala Ala Thr 
            260                 265                 270         


Cys Asp Tyr Val Lys Ala Lys Thr Arg Ser Lys Lys Thr Ile Asn Leu 
        275                 280                 285             


Ser Leu Asp Glu Trp Asn Val Trp Tyr His Ser Asn Glu Ala Asp Lys 
    290                 295                 300                 


Lys Val Glu Pro Trp Ile Thr Ala Arg Pro Ile Leu Glu Asp Ile Tyr 
305                 310                 315                 320 


Asn Phe Glu Asp Ala Leu Leu Val Gly Ser Leu Leu Ile Thr Met Leu 
                325                 330                 335     


Gln His Ala Asp Arg Val Lys Ile Ala Cys Leu Ala Gln Leu Val Asn 
            340                 345                 350         


Val Ile Ala Pro Ile Met Thr Glu Lys Gly Gly Glu Ala Trp Arg Gln 
        355                 360                 365             


Pro Ile Phe Tyr Pro Tyr Met His Ala Ser Val Tyr Gly Arg Gly Glu 
    370                 375                 380                 


Ser Leu Lys Pro Leu Ile Ser Ser Pro Lys Tyr Asp Cys Ser Asp Phe 
385                 390                 395                 400 


Thr Asp Val Pro Tyr Val Asp Ala Ala Val Val Tyr Ser Glu Glu Glu 
                405                 410                 415     


Glu Thr Leu Thr Ile Phe Ala Val Asn Lys Ala Glu Asp Gln Met Glu 
            420                 425                 430         


Thr Glu Ile Ser Leu Arg Gly Phe Glu Ser Tyr Gln Ile Ala Glu His 
        435                 440                 445             


Ile Val Leu Glu His Gln Asp Ile Lys Ala Thr Asn Gln His Asn Arg 
    450                 455                 460                 


Lys Asn Val Val Pro His Ser Asn Gly Ser Ser Ser Val Ser Glu Asn 
465                 470                 475                 480 


Gly Leu Thr Ala His Phe Thr Pro Leu Ser Trp Asn Val Ile Arg Leu 
                485                 490                 495     


Lys Lys Gln Ser 
            500 


<210>  71
<211>  506
<212>  PRT
<213>  Bacillus NRRL B-14911

<400>  71

Met Thr Leu Asn Ala His Lys Ala Lys Met Leu Ile Asp Lys Ser Phe 
1               5                   10                  15      


Arg Ile Ser Asp Ile Asp Pro Arg Ile Tyr Gly Ser Phe Ile Glu Gln 
            20                  25                  30          


Leu Gly Arg Ala Val Tyr Gly Gly Ile Tyr Glu Leu Ser His Ser Ser 
        35                  40                  45              


Ala Asp Glu Asp Gly Phe Arg Gln Asp Val Ile Glu Leu Val Lys Glu 
    50                  55                  60                  


Leu Arg Val Pro Ile Ile Arg Tyr Pro Gly Gly Asn Met Val Ser Ala 
65                  70                  75                  80  


Tyr Asn Trp Glu Asp Gly Ile Gly Pro Lys Glu Leu Arg Pro Lys Arg 
                85                  90                  95      


Leu Asp Leu Ala Trp Asn Ser Leu Glu Thr Asn Glu Val Gly Thr Asn 
            100                 105                 110         


Glu Phe Ala Ala Trp Ala Lys Lys Val Asn Ala Glu Val Met Met Ala 
        115                 120                 125             


Val Asn Leu Gly Thr Arg Gly Ile Asp Ala Ala Arg Asn Leu Val Glu 
    130                 135                 140                 


Tyr Cys Asn His Pro Gly Gly Thr Tyr Trp Ser Asp Leu Arg Lys Glu 
145                 150                 155                 160 


His Gly Tyr Thr Asp Pro His Asn Ile Lys Val Trp Cys Leu Gly Asn 
                165                 170                 175     


Glu Met Asp Gly Pro Trp Gln Ile Gly Met Lys Thr Ala Tyr Glu Tyr 
            180                 185                 190         


Gly Arg Leu Ala Ala Glu Thr Ala Lys Ala Met Lys Leu Val Asp Pro 
        195                 200                 205             


Ser Ile Glu Leu Val Ser Cys Gly Ser Ser Gly Ser Gly Met Pro Thr 
    210                 215                 220                 


Phe Pro Glu Trp Glu Ala Glu Thr Leu Glu His Thr Tyr Glu Ala Ala 
225                 230                 235                 240 


Asp Tyr Ile Ser Leu His Gln Tyr Tyr Gly Asn Arg Asp Asn Asp Ser 
                245                 250                 255     


Ala Asn Tyr Leu Ala Ser Thr Leu Asp Met Asp Ser Phe Ile Lys Thr 
            260                 265                 270         


Val Thr Ala Ala Cys Asp Tyr Met Lys Ala Lys Lys Arg Ser Lys Lys 
        275                 280                 285             


Thr Met Asn Leu Ser Phe Asp Glu Trp Asn Val Trp Phe His Ser Asn 
    290                 295                 300                 


Asp Gln Asp Lys Ala Ile Glu Pro Trp Ser Leu Ser Pro Pro Leu Leu 
305                 310                 315                 320 


Glu Asp Ile Tyr Thr Phe Glu Asp Ala Leu Leu Val Gly Ser Met Leu 
                325                 330                 335     


Asn Thr Leu Leu Lys His Ser Asp Arg Val Lys Ile Ala Cys Met Ala 
            340                 345                 350         


Gln Leu Val Asn Val Ile Ala Pro Ile Met Thr Glu Thr Gly Gly Gly 
        355                 360                 365             


Ile Trp Lys Gln Ser Ile Phe Tyr Pro Phe Tyr Tyr Thr Ser Val Tyr 
    370                 375                 380                 


Gly Arg Gly Thr Ala Leu His Ser Ile Val Asp Ser Pro Lys Tyr Asp 
385                 390                 395                 400 


Ser Lys Asp Phe Thr Asp Val Pro Phe Leu Asp Gln Ser Val Val Tyr 
                405                 410                 415     


Asn Glu Glu Ser Glu Glu Leu Val Ile Phe Ala Val Asn Arg Ser Leu 
            420                 425                 430         


Asp Thr Gln Leu Leu Val Asp Val Asp Ile Arg Ser Phe Glu Gly Tyr 
        435                 440                 445             


Lys Leu Ala Glu Gln Ile Val Leu Lys Asn Glu Asn Pro Lys Ala Val 
    450                 455                 460                 


Asn Ser Ile Asn Asp Glu Gln Val Lys Pro Glu Lys Gly Asn Asp Ser 
465                 470                 475                 480 


Tyr Ile Glu Asn Gly Thr Leu Thr Ala Val Leu Pro Lys Met Ser Trp 
                485                 490                 495     


Asn Met Phe Arg Leu Lys Lys Leu Glu Val 
            500                 505     


<210>  72
<211>  500
<212>  PRT
<213>  Bacillus halodurans

<400>  72

Met Thr Leu Thr Ala Thr Met Val Val Asp Lys Ser Phe Lys Ile Gly 
1               5                   10                  15      


Glu Ile Asp Lys Arg Ile Tyr Gly Ser Phe Ile Glu His Leu Gly Arg 
            20                  25                  30          


Ala Val Tyr Glu Gly Ile Tyr Glu Pro Gly His Pro Asp Gly Asp Glu 
        35                  40                  45              


Gln Gly Phe Arg Lys Asp Val Ile Arg Leu Val Gln Glu Leu Gln Val 
    50                  55                  60                  


Pro Leu Val Arg Tyr Pro Gly Gly Asn Phe Val Ser Gly Tyr Asn Trp 
65                  70                  75                  80  


Glu Asp Gly Val Gly Pro Val Ser Glu Arg Pro Lys Arg Leu Asp Leu 
                85                  90                  95      


Ala Trp Arg Thr Thr Glu Thr Asn Glu Ile Gly Thr Asn Glu Phe Val 
            100                 105                 110         


Asp Trp Ala Lys Lys Val Gly Ala Glu Val Asn Met Ala Val Asn Leu 
        115                 120                 125             


Gly Ser Arg Gly Val Asp Ala Ala Arg Asn Leu Val Glu Tyr Cys Asn 
    130                 135                 140                 


His Pro Ser Gly Ser Tyr Trp Ser Asp Leu Arg Ile Ser His Gly Tyr 
145                 150                 155                 160 


Lys Asp Pro His Asn Ile Lys Thr Trp Cys Leu Gly Asn Glu Met Asp 
                165                 170                 175     


Gly Pro Trp Gln Ile Gly Gln Lys Thr Ala Glu Glu Tyr Gly Arg Val 
            180                 185                 190         


Ala Ala Glu Ala Gly Lys Val Met Lys Leu Val Asp Pro Ser Ile Glu 
        195                 200                 205             


Leu Val Ala Cys Gly Ser Ser Asn Ser Lys Met Ala Thr Phe Ala Asp 
    210                 215                 220                 


Trp Glu Ala Thr Val Leu Asp His Thr Tyr Asp Tyr Val Asp Tyr Ile 
225                 230                 235                 240 


Ser Leu His Thr Tyr Tyr Gly Asn Arg Asp Asp Asp Leu Ala Asn Tyr 
                245                 250                 255     


Leu Ala Gln Ser Met Asp Met Asp Glu Phe Ile Arg Ser Val Ile Ala 
            260                 265                 270         


Ile Ala Asp Tyr Val Lys Ala Lys Lys Arg Ser Lys Lys Thr Ile His 
        275                 280                 285             


Leu Ser Phe Asp Glu Trp Asn Val Trp Phe His Ser Asn Glu Ala Asp 
    290                 295                 300                 


Arg Gln Ile Thr Pro Trp Ser Val Ala Pro Pro Leu Leu Glu Asp Ile 
305                 310                 315                 320 


Tyr Thr Phe Glu Asp Ala Leu Leu Val Gly Ser Met Leu Ile Thr Leu 
                325                 330                 335     


Leu Lys His Ala Asp Arg Val Lys Ile Ala Cys Leu Ala Gln Leu Val 
            340                 345                 350         


Asn Val Ile Ala Pro Ile Met Thr Glu Lys Gly Gly Pro Ala Trp Lys 
        355                 360                 365             


Gln Thr Ile Phe Tyr Pro Tyr Met His Ala Ser Val Tyr Gly Arg Gly 
    370                 375                 380                 


Val Ala Leu Gln Ala Gln Ile Ser Ser Pro Lys Tyr Asp Ser Lys Asp 
385                 390                 395                 400 


Phe Thr Asp Val Pro Tyr Leu Asp Ala Ala Val Val His Leu Glu Glu 
                405                 410                 415     


Ala Glu Glu Val Thr Ile Phe Ala Val Asn Lys His Gln Thr Glu Ser 
            420                 425                 430         


Leu Asn Leu Gln Cys Asp Met Arg Ser Phe Glu Gly Tyr His Val Leu 
        435                 440                 445             


Glu His Ile Val Leu Glu His Glu Asn Met Lys Ala Thr Asn Gln Gly 
    450                 455                 460                 


Arg Glu Gln Val Thr Pro His His Asn Gly Asp Ser Ala Ile Asp Gln 
465                 470                 475                 480 


Gly Arg Leu Thr Ala Asn Leu Ala Lys Leu Ser Trp Asn Val Ile Arg 
                485                 490                 495     


Leu Gly Lys Lys 
            500 


<210>  73
<211>  502
<212>  PRT
<213>  Bacillus licheniformis

<400>  73

Met Thr Val His Lys Ala Lys Met Thr Ile Asp Lys Glu Tyr Lys Val 
1               5                   10                  15      


Ala Glu Ile Asp Lys Arg Ile Tyr Gly Ser Phe Ile Glu His Leu Gly 
            20                  25                  30          


Arg Ala Val Tyr Glu Gly Ile Tyr Glu Pro Asp His Pro Glu Ala Asp 
        35                  40                  45              


Glu Ser Gly Phe Arg Lys Asp Val Ile Lys Leu Val Arg Glu Leu Lys 
    50                  55                  60                  


Val Pro Phe Ile Arg Tyr Pro Gly Gly Asn Phe Val Ser Gly Tyr Asn 
65                  70                  75                  80  


Trp Glu Asp Gly Val Gly Pro Val Glu Gln Arg Pro Thr Arg Leu Asp 
                85                  90                  95      


Leu Ala Trp Ala Thr Thr Glu Pro Asn Leu Ile Gly Thr Asn Glu Phe 
            100                 105                 110         


Met Asp Trp Ala Lys Leu Val Gly Ala Glu Val Asn Met Ala Val Asn 
        115                 120                 125             


Leu Gly Thr Arg Gly Ile Asp Ala Ala Arg Asn Leu Val Glu Tyr Cys 
    130                 135                 140                 


Asn His Pro Ser Gly Ser Tyr Tyr Ser Asp Leu Arg Lys Ser His Gly 
145                 150                 155                 160 


Tyr Lys Glu Pro His Lys Ile Lys Thr Trp Cys Leu Gly Asn Glu Met 
                165                 170                 175     


Asp Gly Pro Trp Gln Ile Gly His Lys Thr Ala Ala Glu Tyr Gly Arg 
            180                 185                 190         


Leu Ala Ala Glu Ala Ala Lys Val Met Lys Trp Thr Asp Pro Ser Ile 
        195                 200                 205             


Glu Leu Val Ala Cys Gly Ser Ser Gly Ser Gly Met Pro Thr Phe Ile 
    210                 215                 220                 


Asp Trp Glu Thr Thr Val Leu Asp His Thr Tyr Glu His Val Glu Tyr 
225                 230                 235                 240 


Ile Ser Leu His Ser Tyr Tyr Gly Asn Arg Asp Asn Asp Leu Pro Asn 
                245                 250                 255     


Tyr Leu Ala Arg Ser Leu Asp Met Asp His Phe Ile Lys Thr Val Ile 
            260                 265                 270         


Ser Val Cys Asp Tyr Met Lys Ala Lys Lys Lys Ser Lys Lys Thr Ile 
        275                 280                 285             


His Leu Ser Tyr Asp Glu Trp Asn Val Trp Tyr His Ser Asn Glu Lys 
    290                 295                 300                 


Asp Lys Glu Ala Glu Arg Trp Ala Lys Ala Pro His Leu Leu Glu Asp 
305                 310                 315                 320 


Ile Tyr Asn Phe Glu Asp Ala Leu Leu Val Gly Cys Met Leu Ile Thr 
                325                 330                 335     


Met Leu Lys His Ala Asp Arg Val Lys Ile Ala Cys Leu Ala Gln Leu 
            340                 345                 350         


Val Asn Val Ile Ala Pro Ile Met Thr Asp Lys Gly Gly Glu Ala Trp 
        355                 360                 365             


Arg Gln Thr Ile Phe Tyr Pro Phe Met His Ala Ser Val Tyr Gly Arg 
    370                 375                 380                 


Gly Thr Val Leu Gln Thr Ala Val Ser Ser Pro Lys Tyr Asp Ala Lys 
385                 390                 395                 400 


Asp Phe Thr Asp Val Pro Tyr Leu Glu Ser Val Ser Val Phe Asn Glu 
                405                 410                 415     


Glu Ala Glu Glu Leu Thr Val Phe Ala Val Asn Arg Ala Thr Asp Ala 
            420                 425                 430         


Gly Leu Glu Met Glu Ala Asp Met Arg Ser Phe Glu Gly Tyr Ser Val 
        435                 440                 445             


Ser Glu His Ile Val Leu Glu His Glu Asp His Lys Ala Thr Asn Glu 
    450                 455                 460                 


Lys Asp Arg Asn Asn Val Val Pro His Ser Gly Gly Asp Ala Lys Val 
465                 470                 475                 480 


Cys Asp Gly Arg Leu Thr Ala His Leu Pro Lys Leu Ser Trp Asn Val 
                485                 490                 495     


Ile Arg Met Lys Lys Gln 
            500         


<210>  74
<211>  502
<212>  PRT
<213>  Bacillus licheniformis

<400>  74

Met Thr Val His Lys Ala Lys Met Thr Ile Asp Lys Glu Tyr Lys Val 
1               5                   10                  15      


Ala Glu Ile Asp Lys Arg Ile Tyr Gly Ser Phe Ile Glu His Leu Gly 
            20                  25                  30          


Arg Ala Val Tyr Glu Gly Ile Tyr Glu Pro Asp His Pro Glu Ala Asp 
        35                  40                  45              


Glu Ser Gly Phe Arg Lys Asp Val Ile Lys Leu Val Arg Glu Leu Lys 
    50                  55                  60                  


Val Pro Phe Ile Arg Tyr Pro Gly Gly Asn Phe Val Ser Gly Tyr Asn 
65                  70                  75                  80  


Trp Glu Asp Gly Val Gly Pro Val Glu Gln Arg Pro Thr Arg Leu Asp 
                85                  90                  95      


Leu Ala Trp Ala Thr Thr Glu Pro Asn Leu Ile Gly Thr Asn Glu Phe 
            100                 105                 110         


Met Asp Trp Ala Lys Leu Val Gly Ala Glu Val Asn Met Ala Val Asn 
        115                 120                 125             


Leu Gly Thr Arg Gly Ile Asp Ala Ala Arg Asn Leu Val Glu Tyr Cys 
    130                 135                 140                 


Asn His Pro Ser Gly Ser Tyr Tyr Ser Asp Leu Arg Lys Ser His Gly 
145                 150                 155                 160 


Tyr Lys Glu Pro His Lys Ile Lys Thr Trp Cys Leu Gly Asn Glu Met 
                165                 170                 175     


Asp Gly Pro Trp Gln Ile Gly His Lys Thr Ala Ala Glu Tyr Gly Arg 
            180                 185                 190         


Leu Ala Ala Glu Ala Ala Lys Val Met Lys Trp Thr Asp Pro Ser Ile 
        195                 200                 205             


Glu Leu Val Ala Cys Gly Ser Ser Gly Ser Gly Met Pro Thr Phe Ile 
    210                 215                 220                 


Asp Trp Glu Thr Thr Val Leu Asp His Thr Tyr Glu His Val Glu Tyr 
225                 230                 235                 240 


Ile Ser Leu His Ser Tyr Tyr Gly Asn Arg Asp Asn Asp Leu Pro Asn 
                245                 250                 255     


Tyr Leu Ala Arg Ser Leu Asp Met Asp His Phe Ile Lys Thr Val Ile 
            260                 265                 270         


Ser Val Cys Asp Tyr Met Lys Ala Lys Lys Lys Ser Lys Lys Thr Ile 
        275                 280                 285             


His Leu Ser Tyr Asp Glu Trp Asn Val Trp Tyr His Ser Asn Glu Lys 
    290                 295                 300                 


Asp Lys Glu Ala Glu Arg Trp Ala Lys Ala Pro His Leu Leu Glu Asp 
305                 310                 315                 320 


Ile Tyr Asn Phe Glu Asp Ala Leu Leu Val Gly Cys Met Leu Ile Thr 
                325                 330                 335     


Met Leu Lys His Ala Asp Arg Val Lys Ile Ala Cys Leu Ala Gln Leu 
            340                 345                 350         


Val Asn Val Ile Ala Pro Ile Met Thr Asp Lys Gly Gly Glu Ala Trp 
        355                 360                 365             


Arg Gln Thr Ile Phe Tyr Pro Phe Met His Ala Ser Val Tyr Gly Arg 
    370                 375                 380                 


Gly Thr Val Leu Gln Thr Ala Val Ser Ser Pro Lys Tyr Asp Ala Lys 
385                 390                 395                 400 


Asp Phe Thr Asp Val Pro Tyr Leu Glu Ser Val Ser Val Phe Asn Glu 
                405                 410                 415     


Glu Ala Glu Glu Leu Thr Val Phe Ala Val Asn Arg Ala Thr Asp Ala 
            420                 425                 430         


Gly Leu Glu Met Glu Ala Asp Met Arg Ser Phe Glu Gly Tyr Ser Val 
        435                 440                 445             


Ser Glu His Ile Val Leu Glu His Glu Asp His Lys Ala Thr Asn Glu 
    450                 455                 460                 


Lys Asp Arg Asn Asn Val Val Pro His Ser Gly Gly Asp Ala Lys Val 
465                 470                 475                 480 


Cys Asp Gly Arg Leu Thr Ala His Leu Pro Lys Leu Ser Trp Asn Val 
                485                 490                 495     


Ile Arg Met Lys Lys Gln 
            500         


<210>  75
<211>  1506
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 68

<400>  75
atgtccaacc tgaaagcgaa aatgaccatc gacccggcgt accgcctcgc ggagaccgac     60

cctcgcatct acgggtcctt cattgaacac ctcggccgcg ccgtctacgg cggcatctac    120

gatccgagcc atcccaccgc ggatgaggac ggattccgtc aggacgtgat cgatctcgtc    180

aaggagctca acgtccccat cgtccgctat ccaggcggca atttcgtctc gggctaccgt    240

tgggaagacg gcgtggggcc tgtggaacag cgccccgttc agctcgatct cgcctggcgc    300

agcctggagc cgaatcgcgt gggcctcaat gaattcgcac gctgggcgaa gaaggcgaac    360

agccaggtca tgatggccgt caacctcggc acccgcggca tcgaagaggc caagcagatt    420

gtcgaatatt gcaatcaccc cggaggaagc tactggagcg acctccgccg caagcacggt    480

atcgagcagc cgcacggcat ccgcgtctgg tgcctcggca acgagatgga cgggccttgg    540

cagatcggcc acaagacggc ggacgaatac ggccgcctcg cgcaggaggc cgccaaggtc    600

atgaagtggg tcgatccgtc catcgaactc gtcgcgtgcg gaagctccgg gtccaaaatg    660

gccacgttcc ccgattggga gcggattgtc ctcgagcacg cttacgacga ggtggactac    720

ctgtcgctgc acacgtacta cggcaaccgc gacggggatc tcgccaactt cctggcgtgt    780

tcgctggata tggacgcgtt cattcgcgcc gtcgtggcga catgcgactt cgttcgcgcg    840

aaaaagcgct ccaacaagac catctatctc tcgttcgacg aatggaacgt gtggttccac    900

tcgaacgagg cggacaaaca ggtcgagccg tggcaggtgg ggccgccgct cctcgaagac    960

gtgtacacca tggaagacgc gctcgtggtg ggctgcatgc tcatcacgct gctgaagcac   1020

gccgatcgcg tccggattgc gtgcctcgcg cagcttgtca acgtgattgc gcccatcatg   1080

acggaaaacg gcggcccgag ctggcggcag accatcttct atccgttcgc tcacgcctcg   1140

aacctcgcgc acggcgtggt gttgtatgcg ccagtggagt cgccgaaata cgacagcaag   1200

gacttcacgg acgtgccata cctcgaggcg gtgccggtgt ggaacgaggc ggcgggcgag   1260

atggtcctcc tggcggtgaa ccgcgccgag gagccgctcg cgctcgacgt ggacctgcgc   1320

ggtttcccca acgcccggtc cgaagagcac atcgtgctca cgcatccgaa tatgaaagcg   1380

gtcaatacga aagaacgtcc gaacgaggtt gtcccccaaa agcggtccat cggcgccgtg   1440

gacgcggggc gacttgcggt cgaacttcca gcgctgtcgt ggaacgtgat tcgcattcgc   1500

gtctga                                                              1506


<210>  76
<211>  1506
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 68

<400>  76
atgtccaacc tgaaagcgcg catgaccatc gacccggcgt accgcatcgc ggagaccgac     60

cctcgcatct acgggtcctt cattgaacac ctcggccgcg ccgtctacgg cggcatctac    120

gatccgagcc atcccaccgc ggatgaggac ggattccgtc aggacgtgat cgatctcgtc    180

aaggagctca acgtccccat cgtccgctat ccaggcggca atttcgtctc gggctaccgt    240

tgggaagacg gcgtggggcc tgtggaacag cgccccgttc agctcgatct cgcctggcgc    300

agcctggagc cgaatcgcgt gggcctcaat gaattcgcac gctgggcgaa gaaggcgaac    360

agccaggtca tgatggccgt caacctcggc acccgcggca tcgaagaggc caagcagatt    420

gtcgaatatt gcaatcaccc cggaggaagc tactggagcg acctccgccg caagcacggt    480

atcgagcagc cgcacggcat ccgcgtctgg tgcctcggca acgagatgga cgggccttgg    540

cagatcggcc acaagacggc ggacgaatac ggccgcctcg cgcaggaggc cgccaaggtc    600

atgaagtggg tcgatccgtc catcgaactc gtcgcgtgcg gaagctccgg gtccaaaatg    660

gccacgttcc ccgattggga gcggattgtc ctcgagcacg cttacgacga ggtggactac    720

ctgtcgctgc acacgtacta cggcaaccgc gacggggatc tcgccaactt cctggcgtgt    780

tcgctggata tggacgcgtt cattcgcgcc gtcgtggcga catgcgactt cgttcgcgcg    840

aaaaagcgct ccaacaagac catctatctc tcgttcgacg aatggaacgt gtggttccac    900

tcgaacgagg cggacaaaca ggtcgagccg tggcaggtgg ggccgccgct cctcgaagac    960

gtgtacacca tggaagacgc gctcgtggtg ggctgcatgc tcatcacgct gctgaagcac   1020

gccgatcgcg tccggattgc gtgcctcgcg cagcttgtca acgtgattgc gcccatcatg   1080

acggaaaacg gcggcccgag ctggcggcag accatcttct atccgttcgc tcacgcctcg   1140

aacctcgcgc acggcgtggt gttgtatgcg ccagtggagt cgccgaaata cgacagcaag   1200

gacttcacgg acgtgccata cctcgaggcg gtgccggtgt ggaacgaggc ggcgggcgag   1260

atggtcctcc tggcggtgaa ccgcgccgag gagccgctcg cgctcgacgt ggacctgcgc   1320

ggtttcccca acgcccggtc cgaagagcac atcgtgctca cgcatccgaa tatgaaagcg   1380

gtcaatacga aagaacgtcc gaacgaggtt gtcccccaaa agcggtccat cggcgccgtg   1440

gacgcggggc gacttgcggt cgaacttcca gcgctgtcgt ggaacgtgat tcgcattcgc   1500

gtctga                                                              1506


<210>  77
<211>  1506
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 68

<400>  77
atgtccaacc tgaaagcgcg catgaccatc gacccggcgt accgcgtcgc ggagaccgac     60

cctcgcatct acgggtcctt cattgaacac ctcggccgcg ccgtctacgg cggcatctac    120

gatccgagcc atcccaccgc ggatgaggac ggattccgtc aggacgtgat cgatctcgtc    180

aaggagctca acgtccccat cgtccgctat ccaggcggca atttcgtctc gggctaccgt    240

tgggaagacg gcgtggggcc tgtggaacag cgccccgttc agctcgatct cgcctggcgc    300

agcctggagc cgaatcgcgt gggcctcaat gaattcgcac gctgggcgaa gaaggcgaac    360

agccaggtca tgatggccgt caacctcggc acccgcggca tcgaagaggc caagcagatt    420

gtcgaatatt gcaatcaccc cggaggaagc tactggagcg acctccgccg caagcacggt    480

atcgagcagc cgcacggcat ccgcgtctgg tgcctcggca acgagatgga cgggccttgg    540

cagatcggcc acaagacggc ggacgaatac ggccgcctcg cgcaggaggc cgccaaggtc    600

atgaagtggg tcgatccgtc catcgaactc gtcgcgtgcg gaagctccgg gtccaaaatg    660

gccacgttcc ccgattggga gcggattgtc ctcgagcacg cttacgacga ggtggactac    720

ctgtcgctgc acacgtacta cggcaaccgc gacggggatc tcgccaactt cctggcgtgt    780

tcgctggata tggacgcgtt cattcgcgcc gtcgtggcga catgcgactt cgttcgcgcg    840

aaaaagcgct ccaacaagac catctatctc tcgttcgacg aatggaacgt gtggttccac    900

tcgaacgagg cggacaaaca ggtcgagccg tggcaggtgg ggccgccgct cctcgaagac    960

gtgtacacca tggaagacgc gctcgtggtg ggctgcatgc tcatcacgct gctgaagcac   1020

gccgatcgcg tccggattgc gtgcctcgcg cagcttgtca acgtgattgc gcccatcatg   1080

acggaaaacg gcggcccgag ctggcggcag accatcttct atccgttcgc tcacgcctcg   1140

aacctcgcgc acggcgtggt gttgtatgcg ccagtggagt cgccgaaata cgacagcaag   1200

gacttcacgg acgtgccata cctcgaggcg gtgccggtgt ggaacgaggc ggcgggcgag   1260

atggtcctcc tggcggtgaa ccgcgccgag gagccgctcg cgctcgacgt ggacctgcgc   1320

ggtttcccca acgcccggtc cgaagagcac atcgtgctca cgcatccgaa tatgaaagcg   1380

gtcaatacga aagaacgtcc gaacgaggtt gtcccccaaa agcggtccat cggcgccgtg   1440

gacgcggggc gacttgcggt cgaacttcca gcgctgtcgt ggaacgtgat tcgcattcgc   1500

gtctga                                                              1506


<210>  78
<211>  1506
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 68

<400>  78
atgtccaacc tgaaagcgcg catgaccatc gacccggcgt accgcctcgc ggagaccgac     60

cctcgcatct acgggtcctt cattgaacac ctcggccgcg ccgtctacgg cggcatctac    120

gatccgagcc atcccaccgc ggatgaggac ggattccgtc aggacgtgat cgatctcgtc    180

agggagctca acgtccccat cgtccgctat ccaggcggca atttcgtctc gggctaccgt    240

tgggaagacg gcgtggggcc tgtggaacag cgccccgttc agctcgatct cgcctggcgc    300

agcctggagc cgaatcgcgt gggcctcaat gaattcgcac gctgggcgaa gaaggcgaac    360

agccaggtca tgatggccgt caacctcggc acccgcggca tcgaagaggc caagcagatt    420

gtcgaatatt gcaatcaccc cggaggaagc tactggagcg acctccgccg caagcacggt    480

atcgagcagc cgcacggcat ccgcgtctgg tgcctcggca acgagatgga cgggccttgg    540

cagatcggcc acaagacggc ggacgaatac ggccgcctcg cgcaggaggc cgccaaggtc    600

atgaagtggg tcgatccgtc catcgaactc gtcgcgtgcg gaagctccgg gtccaaaatg    660

gccacgttcc ccgattggga gcggattgtc ctcgagcacg cttacgacga ggtggactac    720

ctgtcgctgc acacgtacta cggcaaccgc gacggggatc tcgccaactt cctggcgtgt    780

tcgctggata tggacgcgtt cattcgcgcc gtcgtggcga catgcgactt cgttcgcgcg    840

aaaaagcgct ccaacaagac catctatctc tcgttcgacg aatggaacgt gtggttccac    900

tcgaacgagg cggacaaaca ggtcgagccg tggcaggtgg ggccgccgct cctcgaagac    960

gtgtacacca tggaagacgc gctcgtggtg ggctgcatgc tcatcacgct gctgaagcac   1020

gccgatcgcg tccggattgc gtgcctcgcg cagcttgtca acgtgattgc gcccatcatg   1080

acggaaaacg gcggcccgag ctggcggcag accatcttct atccgttcgc tcacgcctcg   1140

aacctcgcgc acggcgtggt gttgtatgcg ccagtggagt cgccgaaata cgacagcaag   1200

gacttcacgg acgtgccata cctcgaggcg gtgccggtgt ggaacgaggc ggcgggcgag   1260

atggtcctcc tggcggtgaa ccgcgccgag gagccgctcg cgctcgacgt ggacctgcgc   1320

ggtttcccca acgcccggtc cgaagagcac atcgtgctca cgcatccgaa tatgaaagcg   1380

gtcaatacga aagaacgtcc gaacgaggtt gtcccccaaa agcggtccat cggcgccgtg   1440

gacgcggggc gacttgcggt cgaacttcca gcgctgtcgt ggaacgtgat tcgcattcgc   1500

gtctga                                                              1506


<210>  79
<211>  1506
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 68

<400>  79
atgtccaacc tgaaagcgcg catgaccatc gacccggcgt accgcctcgc ggagaccgac     60

cctcgcatct acgggtcctt cattgaacac ctcggccgcg ccgtctacgg cggcatctac    120

gatccgagcc atcccaccgc ggatgaggac ggattccgtc aggacgtgat cgatctcgtc    180

aaggagctca acgtccccct cgtccgctat ccaggcggca atttcgtctc gggctaccgt    240

tgggaagacg gcgtggggcc tgtggaacag cgccccgttc agctcgatct cgcctggcgc    300

agcctggagc cgaatcgcgt gggcctcaat gaattcgcac gctgggcgaa gaaggcgaac    360

agccaggtca tgatggccgt caacctcggc acccgcggca tcgaagaggc caagcagatt    420

gtcgaatatt gcaatcaccc cggaggaagc tactggagcg acctccgccg caagcacggt    480

atcgagcagc cgcacggcat ccgcgtctgg tgcctcggca acgagatgga cgggccttgg    540

cagatcggcc acaagacggc ggacgaatac ggccgcctcg cgcaggaggc cgccaaggtc    600

atgaagtggg tcgatccgtc catcgaactc gtcgcgtgcg gaagctccgg gtccaaaatg    660

gccacgttcc ccgattggga gcggattgtc ctcgagcacg cttacgacga ggtggactac    720

ctgtcgctgc acacgtacta cggcaaccgc gacggggatc tcgccaactt cctggcgtgt    780

tcgctggata tggacgcgtt cattcgcgcc gtcgtggcga catgcgactt cgttcgcgcg    840

aaaaagcgct ccaacaagac catctatctc tcgttcgacg aatggaacgt gtggttccac    900

tcgaacgagg cggacaaaca ggtcgagccg tggcaggtgg ggccgccgct cctcgaagac    960

gtgtacacca tggaagacgc gctcgtggtg ggctgcatgc tcatcacgct gctgaagcac   1020

gccgatcgcg tccggattgc gtgcctcgcg cagcttgtca acgtgattgc gcccatcatg   1080

acggaaaacg gcggcccgag ctggcggcag accatcttct atccgttcgc tcacgcctcg   1140

aacctcgcgc acggcgtggt gttgtatgcg ccagtggagt cgccgaaata cgacagcaag   1200

gacttcacgg acgtgccata cctcgaggcg gtgccggtgt ggaacgaggc ggcgggcgag   1260

atggtcctcc tggcggtgaa ccgcgccgag gagccgctcg cgctcgacgt ggacctgcgc   1320

ggtttcccca acgcccggtc cgaagagcac atcgtgctca cgcatccgaa tatgaaagcg   1380

gtcaatacga aagaacgtcc gaacgaggtt gtcccccaaa agcggtccat cggcgccgtg   1440

gacgcggggc gacttgcggt cgaacttcca gcgctgtcgt ggaacgtgat tcgcattcgc   1500

gtctga                                                              1506


<210>  80
<211>  501
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:69 and encoded by SEQ ID NO:75

<400>  80

Met Ser Asn Leu Lys Ala Lys Met Thr Ile Asp Pro Ala Tyr Arg Leu 
1               5                   10                  15      


Ala Glu Thr Asp Pro Arg Ile Tyr Gly Ser Phe Ile Glu His Leu Gly 
            20                  25                  30          


Arg Ala Val Tyr Gly Gly Ile Tyr Asp Pro Ser His Pro Thr Ala Asp 
        35                  40                  45              


Glu Asp Gly Phe Arg Gln Asp Val Ile Asp Leu Val Lys Glu Leu Asn 
    50                  55                  60                  


Val Pro Ile Val Arg Tyr Pro Gly Gly Asn Phe Val Ser Gly Tyr Arg 
65                  70                  75                  80  


Trp Glu Asp Gly Val Gly Pro Val Glu Gln Arg Pro Val Gln Leu Asp 
                85                  90                  95      


Leu Ala Trp Arg Ser Leu Glu Pro Asn Arg Val Gly Leu Asn Glu Phe 
            100                 105                 110         


Ala Arg Trp Ala Lys Lys Ala Asn Ser Gln Val Met Met Ala Val Asn 
        115                 120                 125             


Leu Gly Thr Arg Gly Ile Glu Glu Ala Lys Gln Ile Val Glu Tyr Cys 
    130                 135                 140                 


Asn His Pro Gly Gly Ser Tyr Trp Ser Asp Leu Arg Arg Lys His Gly 
145                 150                 155                 160 


Ile Glu Gln Pro His Gly Ile Arg Val Trp Cys Leu Gly Asn Glu Met 
                165                 170                 175     


Asp Gly Pro Trp Gln Ile Gly His Lys Thr Ala Asp Glu Tyr Gly Arg 
            180                 185                 190         


Leu Ala Gln Glu Ala Ala Lys Val Met Lys Trp Val Asp Pro Ser Ile 
        195                 200                 205             


Glu Leu Val Ala Cys Gly Ser Ser Gly Ser Lys Met Ala Thr Phe Pro 
    210                 215                 220                 


Asp Trp Glu Arg Ile Val Leu Glu His Ala Tyr Asp Glu Val Asp Tyr 
225                 230                 235                 240 


Leu Ser Leu His Thr Tyr Tyr Gly Asn Arg Asp Gly Asp Leu Ala Asn 
                245                 250                 255     


Phe Leu Ala Cys Ser Leu Asp Met Asp Ala Phe Ile Arg Ala Val Val 
            260                 265                 270         


Ala Thr Cys Asp Phe Val Arg Ala Lys Lys Arg Ser Asn Lys Thr Ile 
        275                 280                 285             


Tyr Leu Ser Phe Asp Glu Trp Asn Val Trp Phe His Ser Asn Glu Ala 
    290                 295                 300                 


Asp Lys Gln Val Glu Pro Trp Gln Val Gly Pro Pro Leu Leu Glu Asp 
305                 310                 315                 320 


Val Tyr Thr Met Glu Asp Ala Leu Val Val Gly Cys Met Leu Ile Thr 
                325                 330                 335     


Leu Leu Lys His Ala Asp Arg Val Arg Ile Ala Cys Leu Ala Gln Leu 
            340                 345                 350         


Val Asn Val Ile Ala Pro Ile Met Thr Glu Asn Gly Gly Pro Ser Trp 
        355                 360                 365             


Arg Gln Thr Ile Phe Tyr Pro Phe Ala His Ala Ser Asn Leu Ala His 
    370                 375                 380                 


Gly Val Val Leu Tyr Ala Pro Val Glu Ser Pro Lys Tyr Asp Ser Lys 
385                 390                 395                 400 


Asp Phe Thr Asp Val Pro Tyr Leu Glu Ala Val Pro Val Trp Asn Glu 
                405                 410                 415     


Ala Ala Gly Glu Met Val Leu Leu Ala Val Asn Arg Ala Glu Glu Pro 
            420                 425                 430         


Leu Ala Leu Asp Val Asp Leu Arg Gly Phe Pro Asn Ala Arg Ser Glu 
        435                 440                 445             


Glu His Ile Val Leu Thr His Pro Asn Met Lys Ala Val Asn Thr Lys 
    450                 455                 460                 


Glu Arg Pro Asn Glu Val Val Pro Gln Lys Arg Ser Ile Gly Ala Val 
465                 470                 475                 480 


Asp Ala Gly Arg Leu Ala Val Glu Leu Pro Ala Leu Ser Trp Asn Val 
                485                 490                 495     


Ile Arg Ile Arg Val 
            500     


<210>  81
<211>  501
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:69 and encoded by SEQ ID NO:76

<400>  81

Met Ser Asn Leu Lys Ala Arg Met Thr Ile Asp Pro Ala Tyr Arg Ile 
1               5                   10                  15      


Ala Glu Thr Asp Pro Arg Ile Tyr Gly Ser Phe Ile Glu His Leu Gly 
            20                  25                  30          


Arg Ala Val Tyr Gly Gly Ile Tyr Asp Pro Ser His Pro Thr Ala Asp 
        35                  40                  45              


Glu Asp Gly Phe Arg Gln Asp Val Ile Asp Leu Val Lys Glu Leu Asn 
    50                  55                  60                  


Val Pro Ile Val Arg Tyr Pro Gly Gly Asn Phe Val Ser Gly Tyr Arg 
65                  70                  75                  80  


Trp Glu Asp Gly Val Gly Pro Val Glu Gln Arg Pro Val Gln Leu Asp 
                85                  90                  95      


Leu Ala Trp Arg Ser Leu Glu Pro Asn Arg Val Gly Leu Asn Glu Phe 
            100                 105                 110         


Ala Arg Trp Ala Lys Lys Ala Asn Ser Gln Val Met Met Ala Val Asn 
        115                 120                 125             


Leu Gly Thr Arg Gly Ile Glu Glu Ala Lys Gln Ile Val Glu Tyr Cys 
    130                 135                 140                 


Asn His Pro Gly Gly Ser Tyr Trp Ser Asp Leu Arg Arg Lys His Gly 
145                 150                 155                 160 


Ile Glu Gln Pro His Gly Ile Arg Val Trp Cys Leu Gly Asn Glu Met 
                165                 170                 175     


Asp Gly Pro Trp Gln Ile Gly His Lys Thr Ala Asp Glu Tyr Gly Arg 
            180                 185                 190         


Leu Ala Gln Glu Ala Ala Lys Val Met Lys Trp Val Asp Pro Ser Ile 
        195                 200                 205             


Glu Leu Val Ala Cys Gly Ser Ser Gly Ser Lys Met Ala Thr Phe Pro 
    210                 215                 220                 


Asp Trp Glu Arg Ile Val Leu Glu His Ala Tyr Asp Glu Val Asp Tyr 
225                 230                 235                 240 


Leu Ser Leu His Thr Tyr Tyr Gly Asn Arg Asp Gly Asp Leu Ala Asn 
                245                 250                 255     


Phe Leu Ala Cys Ser Leu Asp Met Asp Ala Phe Ile Arg Ala Val Val 
            260                 265                 270         


Ala Thr Cys Asp Phe Val Arg Ala Lys Lys Arg Ser Asn Lys Thr Ile 
        275                 280                 285             


Tyr Leu Ser Phe Asp Glu Trp Asn Val Trp Phe His Ser Asn Glu Ala 
    290                 295                 300                 


Asp Lys Gln Val Glu Pro Trp Gln Val Gly Pro Pro Leu Leu Glu Asp 
305                 310                 315                 320 


Val Tyr Thr Met Glu Asp Ala Leu Val Val Gly Cys Met Leu Ile Thr 
                325                 330                 335     


Leu Leu Lys His Ala Asp Arg Val Arg Ile Ala Cys Leu Ala Gln Leu 
            340                 345                 350         


Val Asn Val Ile Ala Pro Ile Met Thr Glu Asn Gly Gly Pro Ser Trp 
        355                 360                 365             


Arg Gln Thr Ile Phe Tyr Pro Phe Ala His Ala Ser Asn Leu Ala His 
    370                 375                 380                 


Gly Val Val Leu Tyr Ala Pro Val Glu Ser Pro Lys Tyr Asp Ser Lys 
385                 390                 395                 400 


Asp Phe Thr Asp Val Pro Tyr Leu Glu Ala Val Pro Val Trp Asn Glu 
                405                 410                 415     


Ala Ala Gly Glu Met Val Leu Leu Ala Val Asn Arg Ala Glu Glu Pro 
            420                 425                 430         


Leu Ala Leu Asp Val Asp Leu Arg Gly Phe Pro Asn Ala Arg Ser Glu 
        435                 440                 445             


Glu His Ile Val Leu Thr His Pro Asn Met Lys Ala Val Asn Thr Lys 
    450                 455                 460                 


Glu Arg Pro Asn Glu Val Val Pro Gln Lys Arg Ser Ile Gly Ala Val 
465                 470                 475                 480 


Asp Ala Gly Arg Leu Ala Val Glu Leu Pro Ala Leu Ser Trp Asn Val 
                485                 490                 495     


Ile Arg Ile Arg Val 
            500     


<210>  82
<211>  501
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:69 and encoded by SEQ ID NO:77

<400>  82

Met Ser Asn Leu Lys Ala Arg Met Thr Ile Asp Pro Ala Tyr Arg Val 
1               5                   10                  15      


Ala Glu Thr Asp Pro Arg Ile Tyr Gly Ser Phe Ile Glu His Leu Gly 
            20                  25                  30          


Arg Ala Val Tyr Gly Gly Ile Tyr Asp Pro Ser His Pro Thr Ala Asp 
        35                  40                  45              


Glu Asp Gly Phe Arg Gln Asp Val Ile Asp Leu Val Lys Glu Leu Asn 
    50                  55                  60                  


Val Pro Ile Val Arg Tyr Pro Gly Gly Asn Phe Val Ser Gly Tyr Arg 
65                  70                  75                  80  


Trp Glu Asp Gly Val Gly Pro Val Glu Gln Arg Pro Val Gln Leu Asp 
                85                  90                  95      


Leu Ala Trp Arg Ser Leu Glu Pro Asn Arg Val Gly Leu Asn Glu Phe 
            100                 105                 110         


Ala Arg Trp Ala Lys Lys Ala Asn Ser Gln Val Met Met Ala Val Asn 
        115                 120                 125             


Leu Gly Thr Arg Gly Ile Glu Glu Ala Lys Gln Ile Val Glu Tyr Cys 
    130                 135                 140                 


Asn His Pro Gly Gly Ser Tyr Trp Ser Asp Leu Arg Arg Lys His Gly 
145                 150                 155                 160 


Ile Glu Gln Pro His Gly Ile Arg Val Trp Cys Leu Gly Asn Glu Met 
                165                 170                 175     


Asp Gly Pro Trp Gln Ile Gly His Lys Thr Ala Asp Glu Tyr Gly Arg 
            180                 185                 190         


Leu Ala Gln Glu Ala Ala Lys Val Met Lys Trp Val Asp Pro Ser Ile 
        195                 200                 205             


Glu Leu Val Ala Cys Gly Ser Ser Gly Ser Lys Met Ala Thr Phe Pro 
    210                 215                 220                 


Asp Trp Glu Arg Ile Val Leu Glu His Ala Tyr Asp Glu Val Asp Tyr 
225                 230                 235                 240 


Leu Ser Leu His Thr Tyr Tyr Gly Asn Arg Asp Gly Asp Leu Ala Asn 
                245                 250                 255     


Phe Leu Ala Cys Ser Leu Asp Met Asp Ala Phe Ile Arg Ala Val Val 
            260                 265                 270         


Ala Thr Cys Asp Phe Val Arg Ala Lys Lys Arg Ser Asn Lys Thr Ile 
        275                 280                 285             


Tyr Leu Ser Phe Asp Glu Trp Asn Val Trp Phe His Ser Asn Glu Ala 
    290                 295                 300                 


Asp Lys Gln Val Glu Pro Trp Gln Val Gly Pro Pro Leu Leu Glu Asp 
305                 310                 315                 320 


Val Tyr Thr Met Glu Asp Ala Leu Val Val Gly Cys Met Leu Ile Thr 
                325                 330                 335     


Leu Leu Lys His Ala Asp Arg Val Arg Ile Ala Cys Leu Ala Gln Leu 
            340                 345                 350         


Val Asn Val Ile Ala Pro Ile Met Thr Glu Asn Gly Gly Pro Ser Trp 
        355                 360                 365             


Arg Gln Thr Ile Phe Tyr Pro Phe Ala His Ala Ser Asn Leu Ala His 
    370                 375                 380                 


Gly Val Val Leu Tyr Ala Pro Val Glu Ser Pro Lys Tyr Asp Ser Lys 
385                 390                 395                 400 


Asp Phe Thr Asp Val Pro Tyr Leu Glu Ala Val Pro Val Trp Asn Glu 
                405                 410                 415     


Ala Ala Gly Glu Met Val Leu Leu Ala Val Asn Arg Ala Glu Glu Pro 
            420                 425                 430         


Leu Ala Leu Asp Val Asp Leu Arg Gly Phe Pro Asn Ala Arg Ser Glu 
        435                 440                 445             


Glu His Ile Val Leu Thr His Pro Asn Met Lys Ala Val Asn Thr Lys 
    450                 455                 460                 


Glu Arg Pro Asn Glu Val Val Pro Gln Lys Arg Ser Ile Gly Ala Val 
465                 470                 475                 480 


Asp Ala Gly Arg Leu Ala Val Glu Leu Pro Ala Leu Ser Trp Asn Val 
                485                 490                 495     


Ile Arg Ile Arg Val 
            500     


<210>  83
<211>  501
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:69 and encoded by SEQ ID NO:78

<400>  83

Met Ser Asn Leu Lys Ala Arg Met Thr Ile Asp Pro Ala Tyr Arg Leu 
1               5                   10                  15      


Ala Glu Thr Asp Pro Arg Ile Tyr Gly Ser Phe Ile Glu His Leu Gly 
            20                  25                  30          


Arg Ala Val Tyr Gly Gly Ile Tyr Asp Pro Ser His Pro Thr Ala Asp 
        35                  40                  45              


Glu Asp Gly Phe Arg Gln Asp Val Ile Asp Leu Val Arg Glu Leu Asn 
    50                  55                  60                  


Val Pro Ile Val Arg Tyr Pro Gly Gly Asn Phe Val Ser Gly Tyr Arg 
65                  70                  75                  80  


Trp Glu Asp Gly Val Gly Pro Val Glu Gln Arg Pro Val Gln Leu Asp 
                85                  90                  95      


Leu Ala Trp Arg Ser Leu Glu Pro Asn Arg Val Gly Leu Asn Glu Phe 
            100                 105                 110         


Ala Arg Trp Ala Lys Lys Ala Asn Ser Gln Val Met Met Ala Val Asn 
        115                 120                 125             


Leu Gly Thr Arg Gly Ile Glu Glu Ala Lys Gln Ile Val Glu Tyr Cys 
    130                 135                 140                 


Asn His Pro Gly Gly Ser Tyr Trp Ser Asp Leu Arg Arg Lys His Gly 
145                 150                 155                 160 


Ile Glu Gln Pro His Gly Ile Arg Val Trp Cys Leu Gly Asn Glu Met 
                165                 170                 175     


Asp Gly Pro Trp Gln Ile Gly His Lys Thr Ala Asp Glu Tyr Gly Arg 
            180                 185                 190         


Leu Ala Gln Glu Ala Ala Lys Val Met Lys Trp Val Asp Pro Ser Ile 
        195                 200                 205             


Glu Leu Val Ala Cys Gly Ser Ser Gly Ser Lys Met Ala Thr Phe Pro 
    210                 215                 220                 


Asp Trp Glu Arg Ile Val Leu Glu His Ala Tyr Asp Glu Val Asp Tyr 
225                 230                 235                 240 


Leu Ser Leu His Thr Tyr Tyr Gly Asn Arg Asp Gly Asp Leu Ala Asn 
                245                 250                 255     


Phe Leu Ala Cys Ser Leu Asp Met Asp Ala Phe Ile Arg Ala Val Val 
            260                 265                 270         


Ala Thr Cys Asp Phe Val Arg Ala Lys Lys Arg Ser Asn Lys Thr Ile 
        275                 280                 285             


Tyr Leu Ser Phe Asp Glu Trp Asn Val Trp Phe His Ser Asn Glu Ala 
    290                 295                 300                 


Asp Lys Gln Val Glu Pro Trp Gln Val Gly Pro Pro Leu Leu Glu Asp 
305                 310                 315                 320 


Val Tyr Thr Met Glu Asp Ala Leu Val Val Gly Cys Met Leu Ile Thr 
                325                 330                 335     


Leu Leu Lys His Ala Asp Arg Val Arg Ile Ala Cys Leu Ala Gln Leu 
            340                 345                 350         


Val Asn Val Ile Ala Pro Ile Met Thr Glu Asn Gly Gly Pro Ser Trp 
        355                 360                 365             


Arg Gln Thr Ile Phe Tyr Pro Phe Ala His Ala Ser Asn Leu Ala His 
    370                 375                 380                 


Gly Val Val Leu Tyr Ala Pro Val Glu Ser Pro Lys Tyr Asp Ser Lys 
385                 390                 395                 400 


Asp Phe Thr Asp Val Pro Tyr Leu Glu Ala Val Pro Val Trp Asn Glu 
                405                 410                 415     


Ala Ala Gly Glu Met Val Leu Leu Ala Val Asn Arg Ala Glu Glu Pro 
            420                 425                 430         


Leu Ala Leu Asp Val Asp Leu Arg Gly Phe Pro Asn Ala Arg Ser Glu 
        435                 440                 445             


Glu His Ile Val Leu Thr His Pro Asn Met Lys Ala Val Asn Thr Lys 
    450                 455                 460                 


Glu Arg Pro Asn Glu Val Val Pro Gln Lys Arg Ser Ile Gly Ala Val 
465                 470                 475                 480 


Asp Ala Gly Arg Leu Ala Val Glu Leu Pro Ala Leu Ser Trp Asn Val 
                485                 490                 495     


Ile Arg Ile Arg Val 
            500     


<210>  84
<211>  501
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:69 and encoded by SEQ ID NO:79

<400>  84

Met Ser Asn Leu Lys Ala Arg Met Thr Ile Asp Pro Ala Tyr Arg Leu 
1               5                   10                  15      


Ala Glu Thr Asp Pro Arg Ile Tyr Gly Ser Phe Ile Glu His Leu Gly 
            20                  25                  30          


Arg Ala Val Tyr Gly Gly Ile Tyr Asp Pro Ser His Pro Thr Ala Asp 
        35                  40                  45              


Glu Asp Gly Phe Arg Gln Asp Val Ile Asp Leu Val Lys Glu Leu Asn 
    50                  55                  60                  


Val Pro Leu Val Arg Tyr Pro Gly Gly Asn Phe Val Ser Gly Tyr Arg 
65                  70                  75                  80  


Trp Glu Asp Gly Val Gly Pro Val Glu Gln Arg Pro Val Gln Leu Asp 
                85                  90                  95      


Leu Ala Trp Arg Ser Leu Glu Pro Asn Arg Val Gly Leu Asn Glu Phe 
            100                 105                 110         


Ala Arg Trp Ala Lys Lys Ala Asn Ser Gln Val Met Met Ala Val Asn 
        115                 120                 125             


Leu Gly Thr Arg Gly Ile Glu Glu Ala Lys Gln Ile Val Glu Tyr Cys 
    130                 135                 140                 


Asn His Pro Gly Gly Ser Tyr Trp Ser Asp Leu Arg Arg Lys His Gly 
145                 150                 155                 160 


Ile Glu Gln Pro His Gly Ile Arg Val Trp Cys Leu Gly Asn Glu Met 
                165                 170                 175     


Asp Gly Pro Trp Gln Ile Gly His Lys Thr Ala Asp Glu Tyr Gly Arg 
            180                 185                 190         


Leu Ala Gln Glu Ala Ala Lys Val Met Lys Trp Val Asp Pro Ser Ile 
        195                 200                 205             


Glu Leu Val Ala Cys Gly Ser Ser Gly Ser Lys Met Ala Thr Phe Pro 
    210                 215                 220                 


Asp Trp Glu Arg Ile Val Leu Glu His Ala Tyr Asp Glu Val Asp Tyr 
225                 230                 235                 240 


Leu Ser Leu His Thr Tyr Tyr Gly Asn Arg Asp Gly Asp Leu Ala Asn 
                245                 250                 255     


Phe Leu Ala Cys Ser Leu Asp Met Asp Ala Phe Ile Arg Ala Val Val 
            260                 265                 270         


Ala Thr Cys Asp Phe Val Arg Ala Lys Lys Arg Ser Asn Lys Thr Ile 
        275                 280                 285             


Tyr Leu Ser Phe Asp Glu Trp Asn Val Trp Phe His Ser Asn Glu Ala 
    290                 295                 300                 


Asp Lys Gln Val Glu Pro Trp Gln Val Gly Pro Pro Leu Leu Glu Asp 
305                 310                 315                 320 


Val Tyr Thr Met Glu Asp Ala Leu Val Val Gly Cys Met Leu Ile Thr 
                325                 330                 335     


Leu Leu Lys His Ala Asp Arg Val Arg Ile Ala Cys Leu Ala Gln Leu 
            340                 345                 350         


Val Asn Val Ile Ala Pro Ile Met Thr Glu Asn Gly Gly Pro Ser Trp 
        355                 360                 365             


Arg Gln Thr Ile Phe Tyr Pro Phe Ala His Ala Ser Asn Leu Ala His 
    370                 375                 380                 


Gly Val Val Leu Tyr Ala Pro Val Glu Ser Pro Lys Tyr Asp Ser Lys 
385                 390                 395                 400 


Asp Phe Thr Asp Val Pro Tyr Leu Glu Ala Val Pro Val Trp Asn Glu 
                405                 410                 415     


Ala Ala Gly Glu Met Val Leu Leu Ala Val Asn Arg Ala Glu Glu Pro 
            420                 425                 430         


Leu Ala Leu Asp Val Asp Leu Arg Gly Phe Pro Asn Ala Arg Ser Glu 
        435                 440                 445             


Glu His Ile Val Leu Thr His Pro Asn Met Lys Ala Val Asn Thr Lys 
    450                 455                 460                 


Glu Arg Pro Asn Glu Val Val Pro Gln Lys Arg Ser Ile Gly Ala Val 
465                 470                 475                 480 


Asp Ala Gly Arg Leu Ala Val Glu Leu Pro Ala Leu Ser Trp Asn Val 
                485                 490                 495     


Ile Arg Ile Arg Val 
            500     


<210>  85
<211>  1044
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  85
atgcctggcg ccgggatcgg gagagaccgg cgcatgggtt ctgggataaa ttgtgatgga     60

tgctttttct ctggtttcat ttacataaag gagtctccgc gtccacctcg aaatcgaaat    120

ttgtccaaaa ccttcgattt cgagaggatg gagagcatga gacgaccgag cgcctggatg    180

ttcaccaccc tgacgctcag cttcgccgcg cttggccatg ccacggttct cgcggccacc    240

gaacaacagc ccgccacgta cacggttcgc caaggcgaca cgctgtatcg tatcgccgag    300

gcggatcacc tgccgctcac ggccctggaa ctcgccaatc cccagctgtc caatccgaac    360

gagattgccg cagggcagaa ggttgcgctg ccgacagcct acacggttca gccgggcgac    420

accgtctatc tcatcgccaa ggcgcaccac ctcacgatat cggcgatcct gcaagcgaat    480

ccgggcatcc accccttgga tctcatcgtc ggccagaccc tgtacctgcc catccccgcg    540

tcgaacagca ccgcctccgc gcccccgaac acaagcggga cggctgcgag cgcgggtcag    600

cccacctcca cacagaccca ggtgagccgc gcacagcttc gccaggagat tctgacgtat    660

gcgaaatcgt tccttggcac gccgtactgc tggggcggtg actcgccgaa gacaggcttt    720

gactgctccg gtttcgtcga atatgtcttc ggacacttcg gaatccaact gccgagagag    780

tcgcacgatc aggccacggt cgggacgccc gtcagcccat ccaacctcca gcctggcgat    840

cttctcttct tcaccgacac agacagttac gcttcgctgt atcccaacca cgtgacgcac    900

gtgggcattt acacgggcaa cggggcgatg attgagtcct cgtccgccca caacggcgaa    960

ggcgtggtca ttgtgcaaaa cgtgtttcaa aatccgtact atgtctccca cttctatgga   1020

gcgcgagacg tgatcggccc ctga                                          1044


<210>  86
<211>  347
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  86

Met Pro Gly Ala Gly Ile Gly Arg Asp Arg Arg Met Gly Ser Gly Ile 
1               5                   10                  15      


Asn Cys Asp Gly Cys Phe Phe Ser Gly Phe Ile Tyr Ile Lys Glu Ser 
            20                  25                  30          


Pro Arg Pro Pro Arg Asn Arg Asn Leu Ser Lys Thr Phe Asp Phe Glu 
        35                  40                  45              


Arg Met Glu Ser Met Arg Arg Pro Ser Ala Trp Met Phe Thr Thr Leu 
    50                  55                  60                  


Thr Leu Ser Phe Ala Ala Leu Gly His Ala Thr Val Leu Ala Ala Thr 
65                  70                  75                  80  


Glu Gln Gln Pro Ala Thr Tyr Thr Val Arg Gln Gly Asp Thr Leu Tyr 
                85                  90                  95      


Arg Ile Ala Glu Ala Asp His Leu Pro Leu Thr Ala Leu Glu Leu Ala 
            100                 105                 110         


Asn Pro Gln Leu Ser Asn Pro Asn Glu Ile Ala Ala Gly Gln Lys Val 
        115                 120                 125             


Ala Leu Pro Thr Ala Tyr Thr Val Gln Pro Gly Asp Thr Val Tyr Leu 
    130                 135                 140                 


Ile Ala Lys Ala His His Leu Thr Ile Ser Ala Ile Leu Gln Ala Asn 
145                 150                 155                 160 


Pro Gly Ile His Pro Leu Asp Leu Ile Val Gly Gln Thr Leu Tyr Leu 
                165                 170                 175     


Pro Ile Pro Ala Ser Asn Ser Thr Ala Ser Ala Pro Pro Asn Thr Ser 
            180                 185                 190         


Gly Thr Ala Ala Ser Ala Gly Gln Pro Thr Ser Thr Gln Thr Gln Val 
        195                 200                 205             


Ser Arg Ala Gln Leu Arg Gln Glu Ile Leu Thr Tyr Ala Lys Ser Phe 
    210                 215                 220                 


Leu Gly Thr Pro Tyr Cys Trp Gly Gly Asp Ser Pro Lys Thr Gly Phe 
225                 230                 235                 240 


Asp Cys Ser Gly Phe Val Glu Tyr Val Phe Gly His Phe Gly Ile Gln 
                245                 250                 255     


Leu Pro Arg Glu Ser His Asp Gln Ala Thr Val Gly Thr Pro Val Ser 
            260                 265                 270         


Pro Ser Asn Leu Gln Pro Gly Asp Leu Leu Phe Phe Thr Asp Thr Asp 
        275                 280                 285             


Ser Tyr Ala Ser Leu Tyr Pro Asn His Val Thr His Val Gly Ile Tyr 
    290                 295                 300                 


Thr Gly Asn Gly Ala Met Ile Glu Ser Ser Ser Ala His Asn Gly Glu 
305                 310                 315                 320 


Gly Val Val Ile Val Gln Asn Val Phe Gln Asn Pro Tyr Tyr Val Ser 
                325                 330                 335     


His Phe Tyr Gly Ala Arg Asp Val Ile Gly Pro 
            340                 345         


<210>  87
<211>  371
<212>  PRT
<213>  Clostridium acetobutylicum 

<400>  87

Met His Arg Lys Phe Leu Thr Ala Leu Ile Ala Leu Gly Ile Thr Val 
1               5                   10                  15      


Ser Cys Ser Gly Asn Ile Val Phe Ala Ser Pro Leu Gln Asp Gln Tyr 
            20                  25                  30          


Asn Gln Ser Gln Gln Gln Tyr Gln Asn Ala Leu Lys Ser Val Gln Asp 
        35                  40                  45              


Ile Glu Asn Lys Ile Glu Ala Leu Asp Asn Gln Ile Gly Glu Leu Asn 
    50                  55                  60                  


Asn Ser Ile Asn Asp Thr Asp Lys Arg Ile Asn Glu Ser Lys Gln Asn 
65                  70                  75                  80  


Met Ala Ile Thr Gln Gly Lys Ile Asp Gln Ala Lys Gln Asn Ile Thr 
                85                  90                  95      


Asn Gln Gln Glu Ile Tyr Gly Glu Arg Leu Arg Ala Met Tyr Val Asn 
            100                 105                 110         


Gly Thr Thr Ala Gln Tyr Ile Gly Val Ile Leu Glu Ser Gln Ser Phe 
        115                 120                 125             


Ser Asp Leu Ile Ser Arg Leu Asp Ala Val Lys Asp Val Ile Asn Tyr 
    130                 135                 140                 


Asp Lys Gly Ile Ile Asn Asn Phe Lys Thr Gln Lys Gln Glu Val Glu 
145                 150                 155                 160 


Asn Gln Gln Lys Ile Leu Ala Asp Gln Asn Ser Lys Leu Val Ala Leu 
                165                 170                 175     


Gln Asn Glu Asn His Lys Lys Leu Asp Asp Leu Asn Asn Lys Lys Asn 
            180                 185                 190         


Thr Gln Asn Ser Leu Ile Val Ala Ala Lys Asp Glu Glu Ala Lys His 
        195                 200                 205             


Thr Asn Glu Met Gln Gln Ile Gln Lys Ala Met Asp Asp Glu Lys Lys 
    210                 215                 220                 


Lys Ile Glu Ala Leu Asn Val Ser Thr Asn Ile Gln Leu Lys Pro Val 
225                 230                 235                 240 


Ser Lys Thr Thr Ser Gln Asn Thr Thr Ile Gln Ser Ser Ser Thr Asn 
                245                 250                 255     


Gly Leu Ala Val Val Lys Tyr Ala Glu Thr Phe Leu Asn Thr Pro Tyr 
            260                 265                 270         


Val Trp Gly Gly Asn Lys Pro Gly Gly Phe Asp Cys Ser Gly Leu Val 
        275                 280                 285             


Gln Tyr Val Tyr Ala His Phe Gly Ile Asn Leu Pro Arg Thr Thr Tyr 
    290                 295                 300                 


Glu Gln Val Asn Gln Gly Asn Pro Val Thr Gly Asn Asn Leu Gln Pro 
305                 310                 315                 320 


Gly Asp Leu Leu Phe Phe Glu Pro Gly Ser Asn Gly Pro Glu His Val 
                325                 330                 335     


Gly Ile Tyr Val Gly Asp Gly Asn Phe Ile Glu Ala Pro His Thr Gly 
            340                 345                 350         


Ala Asn Val Arg Phe Ser Pro Leu Arg Ser Tyr Cys Ala Ala Arg Arg 
        355                 360                 365             


Ile Val Asn 
    370     


<210>  88
<211>  503
<212>  PRT
<213>  Clostridium acetobutylicum

<400>  88

Met Lys Lys Leu Phe Thr Asn Leu Leu Leu Leu Cys Ser Ile Val Phe 
1               5                   10                  15      


Leu Gly Ala Leu Leu Asn Gly His Asn Val Gln Ala Ser Asp Ser Phe 
            20                  25                  30          


Thr Tyr Pro Ser Ala Tyr Gly Trp Trp Ser Val Asp Asn Gly Tyr Asp 
        35                  40                  45              


Val Asn Asn Val Asn Ser Arg Met Val Ser Gly Asp Phe Asn Gly Asp 
    50                  55                  60                  


Gly Lys Ala Asp Val Ala Thr Phe Tyr Asp Tyr Gly Asn Gly Ala Ser 
65                  70                  75                  80  


Arg Ile His Val Phe Thr Ser Asn Gly Ser Ser Phe Asp Tyr Ala Ser 
                85                  90                  95      


Ala Tyr Gly Trp Trp Asn Thr Pro Ser Gly Tyr Asp Pro Lys Arg Ile 
            100                 105                 110         


Thr Ala Val Val Ala Gly Asp Phe Asn Gly Asp His Lys Asp Asp Ile 
        115                 120                 125             


Ala Val Ile Tyr Asn Tyr Gly Asn Ser Glu Thr Arg Ile His Val Phe 
    130                 135                 140                 


Ile Ser Thr Gly Ser Ser Phe Ser Tyr Thr Asp Cys Asn Gly Trp Trp 
145                 150                 155                 160 


Asn Ala Thr Gly Tyr Asp Ala Gly Arg Ile Thr Gly Ala Val Ala Gly 
                165                 170                 175     


Asp Phe Asn Gly Asp Gly Lys Ser Asp Ile Ala Thr Met Tyr Asp Tyr 
            180                 185                 190         


Gly Gly Gly Glu Thr Arg Ile His Val Phe Thr Ser Thr Gly Ser Ser 
        195                 200                 205             


Phe Thr Tyr Thr Gly Ala Asn Gly Trp Trp Asn Ser Thr Gly Tyr Asp 
    210                 215                 220                 


Ser Asn Arg Val Lys Gly Arg Val Val Ala Gly Asp Phe Asn Gly Asp 
225                 230                 235                 240 


Gly Lys Thr Asp Ile Ala Ala Met Tyr Asp Tyr Gly Gly Ser Glu Ser 
                245                 250                 255     


Arg Ile His Val Phe Leu Ser Thr Gly Asp Ser Phe Lys Tyr Thr Gly 
            260                 265                 270         


Ala Asn Gly Trp Trp Ser Thr Thr Gly Tyr Asp Ala Asn Lys Val Thr 
        275                 280                 285             


Gly Arg Leu Val Ala Gly Asp Phe Asn Gly Asp Gly Lys Ala Asp Ile 
    290                 295                 300                 


Ala Ala Met Tyr Asp Tyr Gly Asn Ala Glu Thr Arg Ile His Val Leu 
305                 310                 315                 320 


Thr Ser Asn Gly Asp Ser Phe Thr Tyr Thr Gly Ala Asn Gly Trp Trp 
                325                 330                 335     


Asn Thr Thr Gly Tyr Asp Ala Asn Arg Val Thr Gly Arg Val Val Ala 
            340                 345                 350         


Gly Asp Phe Asn Gly Asp His Lys Ala Asp Ile Ala Ala Phe Tyr Asp 
        355                 360                 365             


Tyr Gly Ser Ser Ala Ser Arg Ile His Val Phe Thr Ser Asn Ala Asp 
    370                 375                 380                 


Ser Pro Glu Ser Ser Lys Gly Ala Glu Leu Val Ala Tyr Ala Glu Ser 
385                 390                 395                 400 


Phe Leu Gly Val Pro Tyr Val Trp Gly Gly Ala Asp Pro Ser Gly Phe 
                405                 410                 415     


Asp Cys Ser Gly Leu Val Gln Tyr Cys Tyr Glu His Phe Gly Val Asp 
            420                 425                 430         


Leu Pro Arg Thr Thr Tyr Asp Gln Val Asn Cys Gly Thr Thr Val Thr 
        435                 440                 445             


Asp Asp Leu Gln Pro Gly Asp Leu Leu Phe Phe Gly Ser Ala Thr Ser 
    450                 455                 460                 


Pro Thr His Val Ala Ile Tyr Ala Gly Asn Ser Lys Met Val Glu Ala 
465                 470                 475                 480 


Pro His Thr Gly Ala Asn Val Arg Leu Val Asp Ile Arg Ser Tyr Phe 
                485                 490                 495     


Ile Ala Lys Arg Ile Phe Asn 
            500             


<210>  89
<211>  392
<212>  PRT
<213>  Clostridium acetobutylicum 

<400>  89

Met Tyr Ser Leu Phe Leu Trp Ala Ser Val Lys Ile Phe Thr Met Glu 
1               5                   10                  15      


Ser Arg Gly Arg Tyr Val Val His Lys Arg Ile Leu Ser Thr Val Val 
            20                  25                  30          


Ala Phe Gly Ile Val Ala Ser Met Gly Ser Thr Ser Val Phe Ala Ala 
        35                  40                  45              


Pro Leu Gln Asp Ala Gln Ser Lys Tyr Asp Ala Ser His Lys Asn Val 
    50                  55                  60                  


Gln Asn Leu Glu Glu Asp Ile Gln Lys Met Asp Asn Gln Ile Glu Thr 
65                  70                  75                  80  


Ile Met Ser Gln Arg Asp Ser Val Asp Lys Lys Ile Thr Gln Ser Gln 
                85                  90                  95      


Gln Asn Ile Asn Gln Ala Gln Asn Asp Ile Ala Val Ser Lys Glu Asn 
            100                 105                 110         


Ile Arg Glu Glu Lys Asp Lys Phe Ala Asp Arg Val Arg Ala Leu Tyr 
        115                 120                 125             


Ile Ser Gly Ser Thr Gln Ser Tyr Val Asp Ile Leu Leu Lys Ser Lys 
    130                 135                 140                 


Ser Phe Ser Asp Met Ile Ser Arg Ile Asp Ala Ile Lys Gln Ile Ser 
145                 150                 155                 160 


Asp Tyr Asp Gln Lys Leu Val Ser Asn Leu Lys Asp Ser Gln Gly Arg 
                165                 170                 175     


Ile Glu Ala Lys Lys Asp Lys Ile Val Ser Glu Lys Gln Gln Leu Glu 
            180                 185                 190         


Ala Leu Asn Lys Glu Asn Asp Thr Lys Leu Lys Gln Leu Asn Asp Glu 
        195                 200                 205             


Lys Ser Lys Gln Asn Val Leu Ile Ala Gln Ala Lys Ala Asp Glu Ser 
    210                 215                 220                 


Lys Asn Ala Ala Glu Val Lys Ala Glu Lys Asp Ala Glu Lys Ala Ala 
225                 230                 235                 240 


Ala Gln Ala Arg Leu Val Ala Ala Ala Asn Thr Ala Ala Ser Ser Ala 
                245                 250                 255     


Pro Ala Lys Ala Val Ala Lys Ala Gln Ala Pro Ile Pro Arg Gly Val 
            260                 265                 270         


Ser His Ser Ser Phe Ala Gly Ser Gly Asn Asp Val Val Ser Phe Ala 
        275                 280                 285             


Glu Ser Phe Ser Gly Leu Pro Tyr Ile Trp Gly Ala Glu Asp Pro Ser 
    290                 295                 300                 


Arg Gly Phe Asp Cys Ser Gly Leu Val Gln Tyr Val Tyr Gly His Phe 
305                 310                 315                 320 


Gly Val Ser Leu Gly Arg Thr Thr Tyr Glu Gln Val Asn Gln Gly Thr 
                325                 330                 335     


Thr Val Thr Ala Leu Gln Pro Gly Asp Leu Leu Phe Phe Gly Pro Ala 
            340                 345                 350         


Ser Ala Pro Tyr His Val Ala Ile Tyr Ala Gly Asn Asn Glu Met Val 
        355                 360                 365             


Glu Ala Pro Arg Thr Gly Glu Asn Val Arg Lys Thr Ala Val Arg Gly 
    370                 375                 380                 


Tyr Ser Ile Ala Lys Arg Val Arg 
385                 390         


<210>  90
<211>  379
<212>  PRT
<213>  Lactobacillus delbrueckii 

<400>  90

Met Lys Lys Lys Asn Leu Leu Met Thr Thr Leu Ala Thr Leu Ser Ala 
1               5                   10                  15      


Ser Gly Ala Leu Leu Thr Thr Gly Ala Ser Ala Leu Ala Asp Ser Tyr 
            20                  25                  30          


Thr Val Val Lys Asn Asp Thr Leu Trp Gly Leu Ser Lys Lys Tyr Gly 
        35                  40                  45              


Val Ser Val Ser Asp Leu Lys Lys Ala Asn Gly Val Ser Gly His Leu 
    50                  55                  60                  


Ile Tyr Val Gly Gln Lys Leu Gln Ile Pro Thr Lys Ser Thr Lys Ala 
65                  70                  75                  80  


Thr Lys Thr Ala Lys Thr Ser Thr Ser Thr Ser Thr Val Asp Thr Thr 
                85                  90                  95      


Ser Thr Thr His Thr Val Val Lys Gly Asp Thr Leu Trp Ser Leu Ala 
            100                 105                 110         


Lys Lys Tyr Gly Val Ser Val Ser Ala Leu Met Lys Ala Asn Asn Leu 
        115                 120                 125             


Ser Ser Ser Thr Ile Leu Ile Gly Gln Ser Leu Asn Leu Arg Ala Gly 
    130                 135                 140                 


Met Thr Thr Tyr Gly Val Asn Gly Val Thr Thr Gly Ser Ser Ser Thr 
145                 150                 155                 160 


Ala Ala Ser Ala Asn Thr Ala Ser Ser Thr Ser Thr Thr Ala Ser Ser 
                165                 170                 175     


Gln Ala Pro Lys Asp Lys Lys Thr Ala Thr Lys Ala Lys Ser Thr Thr 
            180                 185                 190         


Thr Asn Thr Ser Ser Asn Ser Asn Thr Ser Thr Ser Ala Asn Thr Gln 
        195                 200                 205             


Ser Gln Ser Thr Ala Ser Asn Ser Ser Ala Ser Thr Thr Thr Asn Thr 
    210                 215                 220                 


Asn Thr Val Ala Ser Asn Ala Asn Thr Thr Ser Ser Thr Asn Thr Ala 
225                 230                 235                 240 


Ala Ser Ser Ser Gln Ala Val Ser Gln Ala Pro Thr Ala Ser Thr Ala 
                245                 250                 255     


Thr Thr Thr Ala Ser Ala Ser Ala Ser Ala Ile Thr Ser Tyr Ala Leu 
            260                 265                 270         


Thr Phe Leu Gly Val Pro Tyr Val Trp Gly Gly Thr Thr Pro Ser Gly 
        275                 280                 285             


Phe Asp Cys Ser Gly Leu Val Gln Tyr Val Tyr Ser His Phe Gly Ile 
    290                 295                 300                 


Asn Leu Gly Arg Thr Thr Tyr Thr Gln Gln Tyr Ala Gly Thr Lys Ile 
305                 310                 315                 320 


Ser Val Ala Ser Ala Gln Ala Gly Asp Leu Tyr Phe Trp Gly Ser Tyr 
                325                 330                 335     


Gly Ser Ala Tyr His Val Ala Ile Ala Leu Gly Gly Gly Gln Tyr Val 
            340                 345                 350         


Met Ala Pro Ala Pro Gly Gln Asn Val Met Thr Gly Ser Val Ser Ser 
        355                 360                 365             


Tyr Thr Pro Ser Phe Ala Val Arg Val Leu Gly 
    370                 375                 


<210>  91
<211>  1044
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 85

<400>  91
atgcctggcg ccgggctcgg gagagaccgg cgcatgggtt ctgggataaa ttgtgatgga     60

tgctttttct ctggtttcat ttacataaag gagtctccgc gtccacctcg aaatcgaaat    120

ttgtccaaaa ccttcgattt cgagaggatg gagagcatga gacgaccgag cgcctggatg    180

ttcaccaccc tgacgctcag cttcgccgcg cttggccatg ccacggttct cgcggccacc    240

gaacaacagc ccgccacgta cacggttcgc caaggcgaca cgctgtatcg tatcgccgag    300

gcggatcacc tgccgctcac ggccctggaa ctcgccaatc cccagctgtc caatccgaac    360

gagattgccg cagggcagaa ggttgcgctg ccgacagcct acacggttca gccgggcgac    420

accgtctatc tcatcgccaa ggcgcaccac ctcacgatat cggcgatcct gcaagcgaat    480

ccgggcatcc accccttgga tctcatcgtc ggccagaccc tgtacctgcc catccccgcg    540

tcgaacagca ccgcctccgc gcccccgaac acaagcggga cggctgcgag cgcgggtcag    600

cccacctcca cacagaccca ggtgagccgc gcacagcttc gccaggagat tctgacgtat    660

gcgaaatcgt tccttggcac gccgtactgc tggggcggtg actcgccgaa gacaggcttt    720

gactgctccg gtttcgtcga atatgtcttc ggacacttcg gaatccaact gccgagagag    780

tcgcacgatc aggccacggt cgggacgccc gtcagcccat ccaacctcca gcctggcgat    840

cttctcttct tcaccgacac agacagttac gcttcgctgt atcccaacca cgtgacgcac    900

gtgggcattt acacgggcaa cggggcgatg attgagtcct cgtccgccca caacggcgaa    960

ggcgtggtca ttgtgcaaaa cgtgtttcaa aatccgtact atgtctccca cttctatgga   1020

gcgcgagacg tgatcggccc ctga                                          1044


<210>  92
<211>  1044
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 85

<400>  92
atgcctggcg ccggggtcgg gagagaccgg cgcatgggtt ctgggataaa ttgtgatgga     60

tgctttttct ctggtttcat ttacataaag gagtctccgc gtccacctcg aaatcgaaat    120

ttgtccaaaa ccttcgattt cgagaggatg gagagcatga gacgaccgag cgcctggatg    180

ttcaccaccc tgacgctcag cttcgccgcg cttggccatg ccacggttct cgcggccacc    240

gaacaacagc ccgccacgta cacggttcgc caaggcgaca cgctgtatcg tatcgccgag    300

gcggatcacc tgccgctcac ggccctggaa ctcgccaatc cccagctgtc caatccgaac    360

gagattgccg cagggcagaa ggttgcgctg ccgacagcct acacggttca gccgggcgac    420

accgtctatc tcatcgccaa ggcgcaccac ctcacgatat cggcgatcct gcaagcgaat    480

ccgggcatcc accccttgga tctcatcgtc ggccagaccc tgtacctgcc catccccgcg    540

tcgaacagca ccgcctccgc gcccccgaac acaagcggga cggctgcgag cgcgggtcag    600

cccacctcca cacagaccca ggtgagccgc gcacagcttc gccaggagat tctgacgtat    660

gcgaaatcgt tccttggcac gccgtactgc tggggcggtg actcgccgaa gacaggcttt    720

gactgctccg gtttcgtcga atatgtcttc ggacacttcg gaatccaact gccgagagag    780

tcgcacgatc aggccacggt cgggacgccc gtcagcccat ccaacctcca gcctggcgat    840

cttctcttct tcaccgacac agacagttac gcttcgctgt atcccaacca cgtgacgcac    900

gtgggcattt acacgggcaa cggggcgatg attgagtcct cgtccgccca caacggcgaa    960

ggcgtggtca ttgtgcaaaa cgtgtttcaa aatccgtact atgtctccca cttctatgga   1020

gcgcgagacg tgatcggccc ctga                                          1044


<210>  93
<211>  1044
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 85

<400>  93
atgcctggcg ccgggatcgg gaaagaccgg cgcatgggtt ctgggataaa ttgtgatgga     60

tgctttttct ctggtttcat ttacataaag gagtctccgc gtccacctcg aaatcgaaat    120

ttgtccaaaa ccttcgattt cgagaggatg gagagcatga gacgaccgag cgcctggatg    180

ttcaccaccc tgacgctcag cttcgccgcg cttggccatg ccacggttct cgcggccacc    240

gaacaacagc ccgccacgta cacggttcgc caaggcgaca cgctgtatcg tatcgccgag    300

gcggatcacc tgccgctcac ggccctggaa ctcgccaatc cccagctgtc caatccgaac    360

gagattgccg cagggcagaa ggttgcgctg ccgacagcct acacggttca gccgggcgac    420

accgtctatc tcatcgccaa ggcgcaccac ctcacgatat cggcgatcct gcaagcgaat    480

ccgggcatcc accccttgga tctcatcgtc ggccagaccc tgtacctgcc catccccgcg    540

tcgaacagca ccgcctccgc gcccccgaac acaagcggga cggctgcgag cgcgggtcag    600

cccacctcca cacagaccca ggtgagccgc gcacagcttc gccaggagat tctgacgtat    660

gcgaaatcgt tccttggcac gccgtactgc tggggcggtg actcgccgaa gacaggcttt    720

gactgctccg gtttcgtcga atatgtcttc ggacacttcg gaatccaact gccgagagag    780

tcgcacgatc aggccacggt cgggacgccc gtcagcccat ccaacctcca gcctggcgat    840

cttctcttct tcaccgacac agacagttac gcttcgctgt atcccaacca cgtgacgcac    900

gtgggcattt acacgggcaa cggggcgatg attgagtcct cgtccgccca caacggcgaa    960

ggcgtggtca ttgtgcaaaa cgtgtttcaa aatccgtact atgtctccca cttctatgga   1020

gcgcgagacg tgatcggccc ctga                                          1044


<210>  94
<211>  1044
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 85

<400>  94
atgcctggcg ccgggatcgg gagagacaag cgcatgggtt ctgggataaa ttgtgatgga     60

tgctttttct ctggtttcat ttacataaag gagtctccgc gtccacctcg aaatcgaaat    120

ttgtccaaaa ccttcgattt cgagaggatg gagagcatga gacgaccgag cgcctggatg    180

ttcaccaccc tgacgctcag cttcgccgcg cttggccatg ccacggttct cgcggccacc    240

gaacaacagc ccgccacgta cacggttcgc caaggcgaca cgctgtatcg tatcgccgag    300

gcggatcacc tgccgctcac ggccctggaa ctcgccaatc cccagctgtc caatccgaac    360

gagattgccg cagggcagaa ggttgcgctg ccgacagcct acacggttca gccgggcgac    420

accgtctatc tcatcgccaa ggcgcaccac ctcacgatat cggcgatcct gcaagcgaat    480

ccgggcatcc accccttgga tctcatcgtc ggccagaccc tgtacctgcc catccccgcg    540

tcgaacagca ccgcctccgc gcccccgaac acaagcggga cggctgcgag cgcgggtcag    600

cccacctcca cacagaccca ggtgagccgc gcacagcttc gccaggagat tctgacgtat    660

gcgaaatcgt tccttggcac gccgtactgc tggggcggtg actcgccgaa gacaggcttt    720

gactgctccg gtttcgtcga atatgtcttc ggacacttcg gaatccaact gccgagagag    780

tcgcacgatc aggccacggt cgggacgccc gtcagcccat ccaacctcca gcctggcgat    840

cttctcttct tcaccgacac agacagttac gcttcgctgt atcccaacca cgtgacgcac    900

gtgggcattt acacgggcaa cggggcgatg attgagtcct cgtccgccca caacggcgaa    960

ggcgtggtca ttgtgcaaaa cgtgtttcaa aatccgtact atgtctccca cttctatgga   1020

gcgcgagacg tgatcggccc ctga                                          1044


<210>  95
<211>  1044
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 85

<400>  95
atgcctggcg ccgggatcgg gagagaccgg aaaatgggtt ctgggataaa ttgtgatgga     60

tgctttttct ctggtttcat ttacataaag gagtctccgc gtccacctcg aaatcgaaat    120

ttgtccaaaa ccttcgattt cgagaggatg gagagcatga gacgaccgag cgcctggatg    180

ttcaccaccc tgacgctcag cttcgccgcg cttggccatg ccacggttct cgcggccacc    240

gaacaacagc ccgccacgta cacggttcgc caaggcgaca cgctgtatcg tatcgccgag    300

gcggatcacc tgccgctcac ggccctggaa ctcgccaatc cccagctgtc caatccgaac    360

gagattgccg cagggcagaa ggttgcgctg ccgacagcct acacggttca gccgggcgac    420

accgtctatc tcatcgccaa ggcgcaccac ctcacgatat cggcgatcct gcaagcgaat    480

ccgggcatcc accccttgga tctcatcgtc ggccagaccc tgtacctgcc catccccgcg    540

tcgaacagca ccgcctccgc gcccccgaac acaagcggga cggctgcgag cgcgggtcag    600

cccacctcca cacagaccca ggtgagccgc gcacagcttc gccaggagat tctgacgtat    660

gcgaaatcgt tccttggcac gccgtactgc tggggcggtg actcgccgaa gacaggcttt    720

gactgctccg gtttcgtcga atatgtcttc ggacacttcg gaatccaact gccgagagag    780

tcgcacgatc aggccacggt cgggacgccc gtcagcccat ccaacctcca gcctggcgat    840

cttctcttct tcaccgacac agacagttac gcttcgctgt atcccaacca cgtgacgcac    900

gtgggcattt acacgggcaa cggggcgatg attgagtcct cgtccgccca caacggcgaa    960

ggcgtggtca ttgtgcaaaa cgtgtttcaa aatccgtact atgtctccca cttctatgga   1020

gcgcgagacg tgatcggccc ctga                                          1044


<210>  96
<211>  347
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:86 and encoded by SEQ ID NO:91

<400>  96

Met Pro Gly Ala Gly Leu Gly Arg Asp Arg Arg Met Gly Ser Gly Ile 
1               5                   10                  15      


Asn Cys Asp Gly Cys Phe Phe Ser Gly Phe Ile Tyr Ile Lys Glu Ser 
            20                  25                  30          


Pro Arg Pro Pro Arg Asn Arg Asn Leu Ser Lys Thr Phe Asp Phe Glu 
        35                  40                  45              


Arg Met Glu Ser Met Arg Arg Pro Ser Ala Trp Met Phe Thr Thr Leu 
    50                  55                  60                  


Thr Leu Ser Phe Ala Ala Leu Gly His Ala Thr Val Leu Ala Ala Thr 
65                  70                  75                  80  


Glu Gln Gln Pro Ala Thr Tyr Thr Val Arg Gln Gly Asp Thr Leu Tyr 
                85                  90                  95      


Arg Ile Ala Glu Ala Asp His Leu Pro Leu Thr Ala Leu Glu Leu Ala 
            100                 105                 110         


Asn Pro Gln Leu Ser Asn Pro Asn Glu Ile Ala Ala Gly Gln Lys Val 
        115                 120                 125             


Ala Leu Pro Thr Ala Tyr Thr Val Gln Pro Gly Asp Thr Val Tyr Leu 
    130                 135                 140                 


Ile Ala Lys Ala His His Leu Thr Ile Ser Ala Ile Leu Gln Ala Asn 
145                 150                 155                 160 


Pro Gly Ile His Pro Leu Asp Leu Ile Val Gly Gln Thr Leu Tyr Leu 
                165                 170                 175     


Pro Ile Pro Ala Ser Asn Ser Thr Ala Ser Ala Pro Pro Asn Thr Ser 
            180                 185                 190         


Gly Thr Ala Ala Ser Ala Gly Gln Pro Thr Ser Thr Gln Thr Gln Val 
        195                 200                 205             


Ser Arg Ala Gln Leu Arg Gln Glu Ile Leu Thr Tyr Ala Lys Ser Phe 
    210                 215                 220                 


Leu Gly Thr Pro Tyr Cys Trp Gly Gly Asp Ser Pro Lys Thr Gly Phe 
225                 230                 235                 240 


Asp Cys Ser Gly Phe Val Glu Tyr Val Phe Gly His Phe Gly Ile Gln 
                245                 250                 255     


Leu Pro Arg Glu Ser His Asp Gln Ala Thr Val Gly Thr Pro Val Ser 
            260                 265                 270         


Pro Ser Asn Leu Gln Pro Gly Asp Leu Leu Phe Phe Thr Asp Thr Asp 
        275                 280                 285             


Ser Tyr Ala Ser Leu Tyr Pro Asn His Val Thr His Val Gly Ile Tyr 
    290                 295                 300                 


Thr Gly Asn Gly Ala Met Ile Glu Ser Ser Ser Ala His Asn Gly Glu 
305                 310                 315                 320 


Gly Val Val Ile Val Gln Asn Val Phe Gln Asn Pro Tyr Tyr Val Ser 
                325                 330                 335     


His Phe Tyr Gly Ala Arg Asp Val Ile Gly Pro 
            340                 345         


<210>  97
<211>  347
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:86 and encoded by SEQ ID NO:92

<400>  97

Met Pro Gly Ala Gly Val Gly Arg Asp Arg Arg Met Gly Ser Gly Ile 
1               5                   10                  15      


Asn Cys Asp Gly Cys Phe Phe Ser Gly Phe Ile Tyr Ile Lys Glu Ser 
            20                  25                  30          


Pro Arg Pro Pro Arg Asn Arg Asn Leu Ser Lys Thr Phe Asp Phe Glu 
        35                  40                  45              


Arg Met Glu Ser Met Arg Arg Pro Ser Ala Trp Met Phe Thr Thr Leu 
    50                  55                  60                  


Thr Leu Ser Phe Ala Ala Leu Gly His Ala Thr Val Leu Ala Ala Thr 
65                  70                  75                  80  


Glu Gln Gln Pro Ala Thr Tyr Thr Val Arg Gln Gly Asp Thr Leu Tyr 
                85                  90                  95      


Arg Ile Ala Glu Ala Asp His Leu Pro Leu Thr Ala Leu Glu Leu Ala 
            100                 105                 110         


Asn Pro Gln Leu Ser Asn Pro Asn Glu Ile Ala Ala Gly Gln Lys Val 
        115                 120                 125             


Ala Leu Pro Thr Ala Tyr Thr Val Gln Pro Gly Asp Thr Val Tyr Leu 
    130                 135                 140                 


Ile Ala Lys Ala His His Leu Thr Ile Ser Ala Ile Leu Gln Ala Asn 
145                 150                 155                 160 


Pro Gly Ile His Pro Leu Asp Leu Ile Val Gly Gln Thr Leu Tyr Leu 
                165                 170                 175     


Pro Ile Pro Ala Ser Asn Ser Thr Ala Ser Ala Pro Pro Asn Thr Ser 
            180                 185                 190         


Gly Thr Ala Ala Ser Ala Gly Gln Pro Thr Ser Thr Gln Thr Gln Val 
        195                 200                 205             


Ser Arg Ala Gln Leu Arg Gln Glu Ile Leu Thr Tyr Ala Lys Ser Phe 
    210                 215                 220                 


Leu Gly Thr Pro Tyr Cys Trp Gly Gly Asp Ser Pro Lys Thr Gly Phe 
225                 230                 235                 240 


Asp Cys Ser Gly Phe Val Glu Tyr Val Phe Gly His Phe Gly Ile Gln 
                245                 250                 255     


Leu Pro Arg Glu Ser His Asp Gln Ala Thr Val Gly Thr Pro Val Ser 
            260                 265                 270         


Pro Ser Asn Leu Gln Pro Gly Asp Leu Leu Phe Phe Thr Asp Thr Asp 
        275                 280                 285             


Ser Tyr Ala Ser Leu Tyr Pro Asn His Val Thr His Val Gly Ile Tyr 
    290                 295                 300                 


Thr Gly Asn Gly Ala Met Ile Glu Ser Ser Ser Ala His Asn Gly Glu 
305                 310                 315                 320 


Gly Val Val Ile Val Gln Asn Val Phe Gln Asn Pro Tyr Tyr Val Ser 
                325                 330                 335     


His Phe Tyr Gly Ala Arg Asp Val Ile Gly Pro 
            340                 345         


<210>  98
<211>  347
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:86 and encoded by SEQ ID NO:93

<400>  98

Met Pro Gly Ala Gly Ile Gly Lys Asp Arg Arg Met Gly Ser Gly Ile 
1               5                   10                  15      


Asn Cys Asp Gly Cys Phe Phe Ser Gly Phe Ile Tyr Ile Lys Glu Ser 
            20                  25                  30          


Pro Arg Pro Pro Arg Asn Arg Asn Leu Ser Lys Thr Phe Asp Phe Glu 
        35                  40                  45              


Arg Met Glu Ser Met Arg Arg Pro Ser Ala Trp Met Phe Thr Thr Leu 
    50                  55                  60                  


Thr Leu Ser Phe Ala Ala Leu Gly His Ala Thr Val Leu Ala Ala Thr 
65                  70                  75                  80  


Glu Gln Gln Pro Ala Thr Tyr Thr Val Arg Gln Gly Asp Thr Leu Tyr 
                85                  90                  95      


Arg Ile Ala Glu Ala Asp His Leu Pro Leu Thr Ala Leu Glu Leu Ala 
            100                 105                 110         


Asn Pro Gln Leu Ser Asn Pro Asn Glu Ile Ala Ala Gly Gln Lys Val 
        115                 120                 125             


Ala Leu Pro Thr Ala Tyr Thr Val Gln Pro Gly Asp Thr Val Tyr Leu 
    130                 135                 140                 


Ile Ala Lys Ala His His Leu Thr Ile Ser Ala Ile Leu Gln Ala Asn 
145                 150                 155                 160 


Pro Gly Ile His Pro Leu Asp Leu Ile Val Gly Gln Thr Leu Tyr Leu 
                165                 170                 175     


Pro Ile Pro Ala Ser Asn Ser Thr Ala Ser Ala Pro Pro Asn Thr Ser 
            180                 185                 190         


Gly Thr Ala Ala Ser Ala Gly Gln Pro Thr Ser Thr Gln Thr Gln Val 
        195                 200                 205             


Ser Arg Ala Gln Leu Arg Gln Glu Ile Leu Thr Tyr Ala Lys Ser Phe 
    210                 215                 220                 


Leu Gly Thr Pro Tyr Cys Trp Gly Gly Asp Ser Pro Lys Thr Gly Phe 
225                 230                 235                 240 


Asp Cys Ser Gly Phe Val Glu Tyr Val Phe Gly His Phe Gly Ile Gln 
                245                 250                 255     


Leu Pro Arg Glu Ser His Asp Gln Ala Thr Val Gly Thr Pro Val Ser 
            260                 265                 270         


Pro Ser Asn Leu Gln Pro Gly Asp Leu Leu Phe Phe Thr Asp Thr Asp 
        275                 280                 285             


Ser Tyr Ala Ser Leu Tyr Pro Asn His Val Thr His Val Gly Ile Tyr 
    290                 295                 300                 


Thr Gly Asn Gly Ala Met Ile Glu Ser Ser Ser Ala His Asn Gly Glu 
305                 310                 315                 320 


Gly Val Val Ile Val Gln Asn Val Phe Gln Asn Pro Tyr Tyr Val Ser 
                325                 330                 335     


His Phe Tyr Gly Ala Arg Asp Val Ile Gly Pro 
            340                 345         


<210>  99
<211>  347
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:86 and encoded by SEQ ID NO:94

<400>  99

Met Pro Gly Ala Gly Ile Gly Arg Asp Lys Arg Met Gly Ser Gly Ile 
1               5                   10                  15      


Asn Cys Asp Gly Cys Phe Phe Ser Gly Phe Ile Tyr Ile Lys Glu Ser 
            20                  25                  30          


Pro Arg Pro Pro Arg Asn Arg Asn Leu Ser Lys Thr Phe Asp Phe Glu 
        35                  40                  45              


Arg Met Glu Ser Met Arg Arg Pro Ser Ala Trp Met Phe Thr Thr Leu 
    50                  55                  60                  


Thr Leu Ser Phe Ala Ala Leu Gly His Ala Thr Val Leu Ala Ala Thr 
65                  70                  75                  80  


Glu Gln Gln Pro Ala Thr Tyr Thr Val Arg Gln Gly Asp Thr Leu Tyr 
                85                  90                  95      


Arg Ile Ala Glu Ala Asp His Leu Pro Leu Thr Ala Leu Glu Leu Ala 
            100                 105                 110         


Asn Pro Gln Leu Ser Asn Pro Asn Glu Ile Ala Ala Gly Gln Lys Val 
        115                 120                 125             


Ala Leu Pro Thr Ala Tyr Thr Val Gln Pro Gly Asp Thr Val Tyr Leu 
    130                 135                 140                 


Ile Ala Lys Ala His His Leu Thr Ile Ser Ala Ile Leu Gln Ala Asn 
145                 150                 155                 160 


Pro Gly Ile His Pro Leu Asp Leu Ile Val Gly Gln Thr Leu Tyr Leu 
                165                 170                 175     


Pro Ile Pro Ala Ser Asn Ser Thr Ala Ser Ala Pro Pro Asn Thr Ser 
            180                 185                 190         


Gly Thr Ala Ala Ser Ala Gly Gln Pro Thr Ser Thr Gln Thr Gln Val 
        195                 200                 205             


Ser Arg Ala Gln Leu Arg Gln Glu Ile Leu Thr Tyr Ala Lys Ser Phe 
    210                 215                 220                 


Leu Gly Thr Pro Tyr Cys Trp Gly Gly Asp Ser Pro Lys Thr Gly Phe 
225                 230                 235                 240 


Asp Cys Ser Gly Phe Val Glu Tyr Val Phe Gly His Phe Gly Ile Gln 
                245                 250                 255     


Leu Pro Arg Glu Ser His Asp Gln Ala Thr Val Gly Thr Pro Val Ser 
            260                 265                 270         


Pro Ser Asn Leu Gln Pro Gly Asp Leu Leu Phe Phe Thr Asp Thr Asp 
        275                 280                 285             


Ser Tyr Ala Ser Leu Tyr Pro Asn His Val Thr His Val Gly Ile Tyr 
    290                 295                 300                 


Thr Gly Asn Gly Ala Met Ile Glu Ser Ser Ser Ala His Asn Gly Glu 
305                 310                 315                 320 


Gly Val Val Ile Val Gln Asn Val Phe Gln Asn Pro Tyr Tyr Val Ser 
                325                 330                 335     


His Phe Tyr Gly Ala Arg Asp Val Ile Gly Pro 
            340                 345         


<210>  100
<211>  347
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:86 and encoded by SEQ ID NO:95

<400>  100

Met Pro Gly Ala Gly Ile Gly Arg Asp Arg Lys Met Gly Ser Gly Ile 
1               5                   10                  15      


Asn Cys Asp Gly Cys Phe Phe Ser Gly Phe Ile Tyr Ile Lys Glu Ser 
            20                  25                  30          


Pro Arg Pro Pro Arg Asn Arg Asn Leu Ser Lys Thr Phe Asp Phe Glu 
        35                  40                  45              


Arg Met Glu Ser Met Arg Arg Pro Ser Ala Trp Met Phe Thr Thr Leu 
    50                  55                  60                  


Thr Leu Ser Phe Ala Ala Leu Gly His Ala Thr Val Leu Ala Ala Thr 
65                  70                  75                  80  


Glu Gln Gln Pro Ala Thr Tyr Thr Val Arg Gln Gly Asp Thr Leu Tyr 
                85                  90                  95      


Arg Ile Ala Glu Ala Asp His Leu Pro Leu Thr Ala Leu Glu Leu Ala 
            100                 105                 110         


Asn Pro Gln Leu Ser Asn Pro Asn Glu Ile Ala Ala Gly Gln Lys Val 
        115                 120                 125             


Ala Leu Pro Thr Ala Tyr Thr Val Gln Pro Gly Asp Thr Val Tyr Leu 
    130                 135                 140                 


Ile Ala Lys Ala His His Leu Thr Ile Ser Ala Ile Leu Gln Ala Asn 
145                 150                 155                 160 


Pro Gly Ile His Pro Leu Asp Leu Ile Val Gly Gln Thr Leu Tyr Leu 
                165                 170                 175     


Pro Ile Pro Ala Ser Asn Ser Thr Ala Ser Ala Pro Pro Asn Thr Ser 
            180                 185                 190         


Gly Thr Ala Ala Ser Ala Gly Gln Pro Thr Ser Thr Gln Thr Gln Val 
        195                 200                 205             


Ser Arg Ala Gln Leu Arg Gln Glu Ile Leu Thr Tyr Ala Lys Ser Phe 
    210                 215                 220                 


Leu Gly Thr Pro Tyr Cys Trp Gly Gly Asp Ser Pro Lys Thr Gly Phe 
225                 230                 235                 240 


Asp Cys Ser Gly Phe Val Glu Tyr Val Phe Gly His Phe Gly Ile Gln 
                245                 250                 255     


Leu Pro Arg Glu Ser His Asp Gln Ala Thr Val Gly Thr Pro Val Ser 
            260                 265                 270         


Pro Ser Asn Leu Gln Pro Gly Asp Leu Leu Phe Phe Thr Asp Thr Asp 
        275                 280                 285             


Ser Tyr Ala Ser Leu Tyr Pro Asn His Val Thr His Val Gly Ile Tyr 
    290                 295                 300                 


Thr Gly Asn Gly Ala Met Ile Glu Ser Ser Ser Ala His Asn Gly Glu 
305                 310                 315                 320 


Gly Val Val Ile Val Gln Asn Val Phe Gln Asn Pro Tyr Tyr Val Ser 
                325                 330                 335     


His Phe Tyr Gly Ala Arg Asp Val Ile Gly Pro 
            340                 345         


<210>  101
<211>  1536
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  101
ttgcatgagg tgaacaggcg acaaaggagg cggttccgcg tggcgcccaa ggttttgcat     60

ctctcgccgg tcgacgatgt cgtggtggcg cttgaaccgc tcgacgtggg ggaggtcgtc    120

gagacccctt tcggccaggt gagcgctcga gcgcccattg cactgggcca caagctcgcc    180

gtcaagcctg tgaagtgcgg agaagcggtg cacaaatacg gttttcccat cggcgtcgca    240

acgcaggaca tcgagccggg cgaatgggtg cacacgcaca atctgcgcac ggcgctctcg    300

gagcgcggct cctacgtgta ccgaccgcac ggttctccgg cactcgtgct tgacgacggc    360

ctcacgttca tgggctatgt ccggtccgac ggacaggtcg gcgtgcgcaa cgagatttgg    420

atcctgaaca cggtcgggtg tgtgaacaaa gtggccgagc ggctagcggc gatggccgac    480

gccaaatggc gcggaggcgg gatcgacggc gtgtaccact tcgcgcatcc gtacgggtgt    540

tcacagctcg gggatgatct cgtctacacc caatctctgc tcgcggggct cgtccgacac    600

cccaacgccg ccggcgtgct tgtgattggg ctcggatgcg agaacaaccg gattgaggcg    660

tttcgggagc ggttggatca agcgtcgctg gagagggtgg cgttcctcga actccagcgc    720

accacggatg aattcgcgga cggcatgcgg ctgttggagg acctcgtcga gcgggcgcgc    780

gcattcgtcc gccagccggt gccagtggct cgtctgaaat tggggctgaa atgcggcgga    840

tccgacggtc tgtcaggcgt cacggcgaat ccactcgtgg gacaggtggc ggaccgcgtc    900

gtcgctcgcg gcggcacggc actcctgacc gaggtgcctg agatgttcgg cgcggagacg    960

gtgctcatgg atcgcgccga cagccctgag acgttcgcca aaatcgtaga tctgattcag   1020

tcgtggaagg attactacac gcgccacggc cagcccgttt atgaaaatcc ctcccccgga   1080

aacaaggcgg gcggcatcac cacactggaa gaaaagtcgc tcggtgccgt gcagaagggc   1140

gggcgccttt cccgggtggt ggacgtcctc ggctacggcg atccggccgt gaaacctggg   1200

ctcaacctga tctcggcgcc tgggaacgac atggtgtcgg tgagcgcgct cgcggcgagc   1260

ggcgcgcagc tgatcctgtt caccacaggc cggggcacgc ccttcggcgg gccggttcca   1320

acgctgaaga ttgcgagcaa ccaccagctt gcgtcgtcga aacctggctg gatcgacttc   1380

gacgcggggc ggatcgcgct cggggaatcg atgaacgatc tcgcggagga attgctgcac   1440

aaggtcattc gcgtggcgtc tggagaagaa ctcgcccgga acgaagtgaa cgggtatcgc   1500

gagatcgcca tcttcaagga cggcgtcacc ctttga                             1536


<210>  102
<211>  511
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  102

Met His Glu Val Asn Arg Arg Gln Arg Arg Arg Phe Arg Val Ala Pro 
1               5                   10                  15      


Lys Val Leu His Leu Ser Pro Val Asp Asp Val Val Val Ala Leu Glu 
            20                  25                  30          


Pro Leu Asp Val Gly Glu Val Val Glu Thr Pro Phe Gly Gln Val Ser 
        35                  40                  45              


Ala Arg Ala Pro Ile Ala Leu Gly His Lys Leu Ala Val Lys Pro Val 
    50                  55                  60                  


Lys Cys Gly Glu Ala Val His Lys Tyr Gly Phe Pro Ile Gly Val Ala 
65                  70                  75                  80  


Thr Gln Asp Ile Glu Pro Gly Glu Trp Val His Thr His Asn Leu Arg 
                85                  90                  95      


Thr Ala Leu Ser Glu Arg Gly Ser Tyr Val Tyr Arg Pro His Gly Ser 
            100                 105                 110         


Pro Ala Leu Val Leu Asp Asp Gly Leu Thr Phe Met Gly Tyr Val Arg 
        115                 120                 125             


Ser Asp Gly Gln Val Gly Val Arg Asn Glu Ile Trp Ile Leu Asn Thr 
    130                 135                 140                 


Val Gly Cys Val Asn Lys Val Ala Glu Arg Leu Ala Ala Met Ala Asp 
145                 150                 155                 160 


Ala Lys Trp Arg Gly Gly Gly Ile Asp Gly Val Tyr His Phe Ala His 
                165                 170                 175     


Pro Tyr Gly Cys Ser Gln Leu Gly Asp Asp Leu Val Tyr Thr Gln Ser 
            180                 185                 190         


Leu Leu Ala Gly Leu Val Arg His Pro Asn Ala Ala Gly Val Leu Val 
        195                 200                 205             


Ile Gly Leu Gly Cys Glu Asn Asn Arg Ile Glu Ala Phe Arg Glu Arg 
    210                 215                 220                 


Leu Asp Gln Ala Ser Leu Glu Arg Val Ala Phe Leu Glu Leu Gln Arg 
225                 230                 235                 240 


Thr Thr Asp Glu Phe Ala Asp Gly Met Arg Leu Leu Glu Asp Leu Val 
                245                 250                 255     


Glu Arg Ala Arg Ala Phe Val Arg Gln Pro Val Pro Val Ala Arg Leu 
            260                 265                 270         


Lys Leu Gly Leu Lys Cys Gly Gly Ser Asp Gly Leu Ser Gly Val Thr 
        275                 280                 285             


Ala Asn Pro Leu Val Gly Gln Val Ala Asp Arg Val Val Ala Arg Gly 
    290                 295                 300                 


Gly Thr Ala Leu Leu Thr Glu Val Pro Glu Met Phe Gly Ala Glu Thr 
305                 310                 315                 320 


Val Leu Met Asp Arg Ala Asp Ser Pro Glu Thr Phe Ala Lys Ile Val 
                325                 330                 335     


Asp Leu Ile Gln Ser Trp Lys Asp Tyr Tyr Thr Arg His Gly Gln Pro 
            340                 345                 350         


Val Tyr Glu Asn Pro Ser Pro Gly Asn Lys Ala Gly Gly Ile Thr Thr 
        355                 360                 365             


Leu Glu Glu Lys Ser Leu Gly Ala Val Gln Lys Gly Gly Arg Leu Ser 
    370                 375                 380                 


Arg Val Val Asp Val Leu Gly Tyr Gly Asp Pro Ala Val Lys Pro Gly 
385                 390                 395                 400 


Leu Asn Leu Ile Ser Ala Pro Gly Asn Asp Met Val Ser Val Ser Ala 
                405                 410                 415     


Leu Ala Ala Ser Gly Ala Gln Leu Ile Leu Phe Thr Thr Gly Arg Gly 
            420                 425                 430         


Thr Pro Phe Gly Gly Pro Val Pro Thr Leu Lys Ile Ala Ser Asn His 
        435                 440                 445             


Gln Leu Ala Ser Ser Lys Pro Gly Trp Ile Asp Phe Asp Ala Gly Arg 
    450                 455                 460                 


Ile Ala Leu Gly Glu Ser Met Asn Asp Leu Ala Glu Glu Leu Leu His 
465                 470                 475                 480 


Lys Val Ile Arg Val Ala Ser Gly Glu Glu Leu Ala Arg Asn Glu Val 
                485                 490                 495     


Asn Gly Tyr Arg Glu Ile Ala Ile Phe Lys Asp Gly Val Thr Leu 
            500                 505                 510     


<210>  103
<211>  497
<212>  PRT
<213>  Bacillus halodurans

<400>  103

Met Asn Glu Lys Phe Ala Tyr Ile His Glu Lys Asp Asn Val Ile Ile 
1               5                   10                  15      


Ala Leu Ser Pro Leu Glu Gln Gly Glu Val Leu Asn Val Asn Gly Leu 
            20                  25                  30          


Pro Ile Thr Leu Ser Glu Ser Ile Pro Arg Gly His Lys Val Ala Ile 
        35                  40                  45              


Val Thr Ile Glu Gln Gly Glu Asp Val Ile Lys Tyr Gly Phe Pro Ile 
    50                  55                  60                  


Gly Lys Ala Thr Thr Thr Ile Gln Pro Gly Ala Trp Val His Ser Gln 
65                  70                  75                  80  


Asn Met Lys Thr Lys Leu Glu Gly Val Gln Glu Tyr Asp Tyr Thr Pro 
                85                  90                  95      


Ser Thr Pro Ser Phe Arg Lys Gln Val Glu Lys Val Arg Thr Phe Gln 
            100                 105                 110         


Gly Tyr Val Arg Asp Asn Gly Asn Val Gly Ile Arg Asn Glu Ile Trp 
        115                 120                 125             


Ile Ile Asn Thr Val Gly Cys Ile Asn Lys Thr Ala Glu Arg Leu Ala 
    130                 135                 140                 


Ala Ile Ser Asn Glu Thr Cys Gly Ala Gly Val Asp Gly Val Tyr His 
145                 150                 155                 160 


Tyr Pro His Leu Phe Gly Cys Ser Gln Leu Gly Asp Asp Leu Leu Tyr 
                165                 170                 175     


Thr Gln Lys Ile Leu Arg Asn Leu Val Leu His Pro Asn Ala Ala Gly 
            180                 185                 190         


Val Leu Val Leu Gly Leu Gly Cys Glu Asn Asn His Ile Ala Ala Phe 
        195                 200                 205             


Lys Gln Val Leu Gly Asp Tyr Asp Asp Arg Arg Val Lys Phe Leu Ala 
    210                 215                 220                 


Val Gln Glu Ala Asp Asn Glu Met Glu Gln Gly Leu Ala Ile Ile Glu 
225                 230                 235                 240 


Glu Leu Ile Ser Tyr Ala Lys Thr Ala Lys Arg Glu Pro Ile Pro Leu 
                245                 250                 255     


Ser Lys Leu Lys Val Gly Leu Lys Cys Gly Gly Ser Asp Gly Phe Ser 
            260                 265                 270         


Gly Ile Thr Ala Asn Pro Leu Val Gly Ala Phe Ser Asp Lys Val Val 
        275                 280                 285             


Ala His Gly Gly Thr Thr Val Met Thr Glu Val Pro Glu Met Phe Gly 
    290                 295                 300                 


Ala Glu Thr Ile Leu Met Asn Arg Ala Lys Asp Gln Ala Thr Phe Glu 
305                 310                 315                 320 


Lys Met Val Arg Leu Ile Asn Asp Phe Lys Glu Tyr Phe Leu Arg His 
                325                 330                 335     


Asn Gln Pro Val Tyr Glu Asn Pro Ser Pro Gly Asn Lys Glu Gly Gly 
            340                 345                 350         


Ile Thr Thr Leu Glu Glu Lys Ser Leu Gly Cys Val Gln Lys Gly Gly 
        355                 360                 365             


Phe Ala Glu Val Val Asp Val Leu Pro Tyr Gly Glu Arg Leu Glu Lys 
    370                 375                 380                 


Pro Gly Leu Asn Leu Leu Gln Gly Pro Gly Asn Asp Leu Val Ser Val 
385                 390                 395                 400 


Thr Ala Leu Ala Ala Ala Gly Ala His Phe Val Leu Phe Thr Thr Gly 
                405                 410                 415     


Arg Gly Thr Pro Phe Gly Gly Pro Val Pro Thr Val Lys Ile Ser Thr 
            420                 425                 430         


Asn Thr Ser Leu Tyr Glu Arg Lys Lys His Trp Ile Asp Phe Asn Ala 
        435                 440                 445             


Gly Arg Leu Val Glu Gly Ala Thr Leu Asp Glu Val Ala Glu Glu Leu 
    450                 455                 460                 


Leu Asn Tyr Gly Val Lys Leu Ala Ser Gly Glu Val Arg Ala Lys Asn 
465                 470                 475                 480 


Glu Glu Tyr Gly Phe Lys Glu Ile Ser Ile Phe Lys Asp Gly Val Ile 
                485                 490                 495     


Leu 
    


<210>  104
<211>  495
<212>  PRT
<213>  Thermosinus carboxydivorans

<400>  104

Met Ala Leu Leu Lys Leu His Glu Arg Asp Asn Val Ala Val Ala Leu 
1               5                   10                  15      


Arg Asp Ile Arg Gln Gly Glu Thr Leu Ala Ala Asp Asn Ala Thr Val 
            20                  25                  30          


Thr Ala Arg Glu Asp Ile Pro Lys Gly His Lys Ile Ala Leu Cys Asp 
        35                  40                  45              


Leu Gln Pro Gly Glu His Val Ile Lys Tyr Gly Phe Pro Ile Gly His 
    50                  55                  60                  


Ala Thr Ser Ser Val Ala Ala Gly Gln Trp Leu His Ser His Asn Val 
65                  70                  75                  80  


Arg Thr Asn Leu Gly Glu Ile Leu Ala Tyr Glu Tyr Lys Pro Glu Pro 
                85                  90                  95      


Pro Ala Val Ser Pro Val Pro Cys Arg His Thr Phe Arg Gly Tyr Arg 
            100                 105                 110         


Arg Pro Asp Gly Arg Val Gly Val Arg Asn Glu Ile Trp Ile Ile Pro 
        115                 120                 125             


Thr Val Ser Cys Val Asn Arg Thr Ala Gln Leu Leu Ala Glu Arg Gly 
    130                 135                 140                 


Ser Ala Leu Ala Arg Asn Met Ala Asn Ile Asp Gly Val Phe Ala Phe 
145                 150                 155                 160 


Thr His Pro Tyr Gly Cys Ser Gln Leu Gly Asp Asp His Arg Ala Thr 
                165                 170                 175     


Gln Thr Ile Leu Ala Asp Leu Val Asn His Pro Asn Ala Gly Ala Val 
            180                 185                 190         


Leu Val Leu Gly Leu Gly Cys Glu Asn Asn Asn Val Pro Glu Phe Gln 
        195                 200                 205             


Lys Val Val Gly Ser Tyr Asn Ala Asp Arg Val Lys Phe Leu Val Ala 
    210                 215                 220                 


Gln Glu Val Glu Asp Glu Ile Ala Ala Gly Leu Glu Leu Leu Ser Asp 
225                 230                 235                 240 


Leu Ile Ala Tyr Ala Gly Gln Phe Leu Arg Glu Asp Cys Pro Ala Ser 
                245                 250                 255     


Glu Leu Val Val Gly Leu Lys Cys Gly Gly Ser Asp Ala Phe Ser Gly 
            260                 265                 270         


Ile Thr Ala Asn Pro Leu Val Gly Ala Phe Ser Asp Leu Leu Ile Ala 
        275                 280                 285             


Cys Gly Gly Ser Thr Val Leu Thr Glu Val Pro Glu Met Phe Gly Ala 
    290                 295                 300                 


Glu Thr Ile Leu Met Asn Arg Ala Gln Asp Lys Ala Val Phe Asp Lys 
305                 310                 315                 320 


Thr Val Arg Leu Ile Asn Asp Phe Lys Asn Tyr Phe Met Ala Tyr Asn 
                325                 330                 335     


Gln Pro Ile Tyr Glu Asn Pro Ser Pro Gly Asn Lys Lys Gly Gly Ile 
            340                 345                 350         


Thr Thr Leu Glu Glu Lys Ser Leu Gly Cys Thr Gln Lys Gly Gly Arg 
        355                 360                 365             


Ala Thr Val Val Asp Val Leu Gly Tyr Gly Glu Thr Val Thr Arg Lys 
    370                 375                 380                 


Gly Leu Asn Leu Leu Asn Gly Pro Gly Asn Asp Ala Val Ala Ala Thr 
385                 390                 395                 400 


Ala Leu Ala Ala Ala Gly Cys His Leu Val Leu Phe Thr Thr Gly Arg 
                405                 410                 415     


Gly Thr Pro Leu Gly Thr Ala Val Pro Thr Val Lys Ile Ala Thr Asn 
            420                 425                 430         


Ser Glu Leu Phe Arg Arg Lys Thr Thr Trp Met Asp Phe Asn Ala Gly 
        435                 440                 445             


Glu Leu Leu Glu Gly Lys Ser Leu Glu Ala Leu Ala Asp Glu Phe Phe 
    450                 455                 460                 


Ala Tyr Val Leu Ala Val Ala Ser Gly Arg Pro Thr Lys Ala Glu Glu 
465                 470                 475                 480 


Met Gly Phe Arg Glu Ile Ala Ile Phe Lys Asn Gly Val Thr Leu 
                485                 490                 495 


<210>  105
<211>  496
<212>  PRT
<213>  Bacillus licheniformis

<400>  105

Met Lys Asp Cys Leu Met Ile Asn Pro Gln Asp Asn Val Gly Ile Ala 
1               5                   10                  15      


Leu Arg Glu Leu Gln Thr Gly Glu Thr Val Thr Val Gly Glu Arg Thr 
            20                  25                  30          


Ile Val Ile Lys Glu Pro Ile Leu Lys Gly His Lys Phe Ala Leu Lys 
        35                  40                  45              


Asp Ile Ala Glu Asn Glu Asn Val Ile Lys Tyr Gly Phe Pro Ile Gly 
    50                  55                  60                  


His Ala Thr Glu Met Ile Gln Thr Gly Glu Trp Val His Thr Lys Asn 
65                  70                  75                  80  


Val Lys Thr Asn Leu Gly Gly Val Glu Glu Tyr Ser Tyr Lys Pro Lys 
                85                  90                  95      


Phe Thr Glu Asn Arg Tyr Gln Lys Glu Pro Leu Thr Phe Lys Gly Phe 
            100                 105                 110         


Lys Arg Lys Asp Gly Lys Thr Gly Ile Arg Asn Glu Leu Trp Ile Val 
        115                 120                 125             


Pro Thr Val Gly Cys Val Asn Gly Ile Ala Glu Leu Ile Ile Lys Glu 
    130                 135                 140                 


Phe Lys Ala Glu Val Gly Ser Ile Ala Pro Phe Glu Ser Val His Val 
145                 150                 155                 160 


Leu Lys His Gln Tyr Gly Cys Ser Gln Leu Gly Asp Asp His Ile Asn 
                165                 170                 175     


Thr Arg Thr Ile Leu Ala Asn Ala Val Asn His Pro Asn Ala Gly Gly 
            180                 185                 190         


Val Leu Val Leu Gly Leu Gly Cys Glu Asn Asn Ser Ile His Glu Phe 
        195                 200                 205             


Arg Glu Ala Leu Gly Asp Tyr Asp His Ser Arg Val Lys Phe Leu Leu 
    210                 215                 220                 


Ser Gln Glu Val Ser Asn Glu Val Thr Glu Gly Val Lys Leu Leu Lys 
225                 230                 235                 240 


Glu Ile Tyr Lys His Ala Lys Gly Asp His Arg Glu Asp Val Pro Leu 
                245                 250                 255     


Ser Glu Leu Lys Ile Gly Leu Lys Cys Gly Gly Ser Asp Gly Phe Ser 
            260                 265                 270         


Gly Ile Thr Ala Asn Pro Leu Leu Gly Arg Leu Ser Asp Phe Leu Ile 
        275                 280                 285             


Ala Gln Gly Gly Thr Ala Val Leu Thr Glu Val Pro Glu Met Phe Gly 
    290                 295                 300                 


Ala Glu Thr Leu Leu Met Glu Arg Ala Glu Asn Glu Glu Val Phe His 
305                 310                 315                 320 


Lys Ile Val Arg Leu Ile Asn Asp Phe Lys Gln Tyr Phe Ile Asp His 
                325                 330                 335     


Arg Gln Pro Val Tyr Glu Asn Pro Ser Pro Gly Asn Lys Ala Gly Gly 
            340                 345                 350         


Ile Thr Thr Leu Glu Asp Lys Ser Leu Gly Cys Thr Gln Lys Ala Gly 
        355                 360                 365             


Thr Ser Lys Val Ala Asp Val Leu Glu Tyr Gly Asp Val Leu Lys Lys 
    370                 375                 380                 


Lys Gly Leu Asn Leu Leu Ser Ala Pro Gly Asn Asp Leu Val Ala Ser 
385                 390                 395                 400 


Ser Ala Leu Ala Ala Ala Gly Cys Gln Ile Val Leu Phe Thr Thr Gly 
                405                 410                 415     


Arg Gly Thr Pro Phe Gly Thr Phe Val Pro Thr Met Lys Ile Ser Thr 
            420                 425                 430         


Asn Thr Ala Ile Tyr Glu Ala Lys Arg His Trp Ile Asp Phe Asn Ala 
        435                 440                 445             


Gly Lys Val Leu Glu Asp Arg Ser Glu Asp Asp Val Leu Lys Glu Leu 
    450                 455                 460                 


Thr Ala Tyr Leu Ile Glu Val Ala Ser Gly Arg Gln Leu Asn Asn Glu 
465                 470                 475                 480 


Ile Asn Asp Phe Arg Glu Leu Ala Ile Phe Lys Thr Gly Val Thr Leu 
                485                 490                 495     


<210>  106
<211>  496
<212>  PRT
<213>  Bacillus licheniformis 

<400>  106

Met Lys Asp Cys Leu Met Ile Asn Pro Gln Asp Asn Val Gly Ile Ala 
1               5                   10                  15      


Leu Arg Glu Leu Gln Thr Gly Glu Thr Val Thr Val Gly Glu Arg Thr 
            20                  25                  30          


Ile Val Ile Lys Glu Pro Ile Leu Lys Gly His Lys Phe Ala Leu Lys 
        35                  40                  45              


Asp Ile Ala Glu Asn Glu Asn Val Ile Lys Tyr Gly Phe Pro Ile Gly 
    50                  55                  60                  


His Ala Thr Glu Met Ile Gln Thr Gly Glu Trp Val His Thr Lys Asn 
65                  70                  75                  80  


Val Lys Thr Asn Leu Gly Gly Val Glu Glu Tyr Ser Tyr Lys Pro Lys 
                85                  90                  95      


Phe Thr Glu Asn Arg Tyr Gln Lys Glu Pro Leu Thr Phe Lys Gly Phe 
            100                 105                 110         


Lys Arg Lys Asp Gly Lys Thr Gly Ile Arg Asn Glu Leu Trp Ile Val 
        115                 120                 125             


Pro Thr Val Gly Cys Val Asn Gly Ile Ala Glu Leu Ile Ile Lys Glu 
    130                 135                 140                 


Phe Lys Ala Glu Val Gly Ser Ile Ala Pro Phe Glu Ser Val His Val 
145                 150                 155                 160 


Leu Lys His Gln Tyr Gly Cys Ser Gln Leu Gly Asp Asp His Ile Asn 
                165                 170                 175     


Thr Arg Thr Ile Leu Ala Asn Ala Val Asn His Pro Asn Ala Gly Gly 
            180                 185                 190         


Val Leu Val Leu Gly Leu Gly Cys Glu Asn Asn Ser Ile His Glu Phe 
        195                 200                 205             


Arg Glu Ala Leu Gly Asp Tyr Asp His Ser Arg Val Lys Phe Leu Leu 
    210                 215                 220                 


Ser Gln Glu Val Ser Asn Glu Val Thr Glu Gly Val Lys Leu Leu Lys 
225                 230                 235                 240 


Glu Ile Tyr Lys His Ala Lys Gly Asp His Arg Glu Asp Val Pro Leu 
                245                 250                 255     


Ser Glu Leu Lys Ile Gly Leu Lys Cys Gly Gly Ser Asp Gly Phe Ser 
            260                 265                 270         


Gly Ile Thr Ala Asn Pro Leu Leu Gly Arg Leu Ser Asp Phe Leu Ile 
        275                 280                 285             


Ala Gln Gly Gly Thr Ala Val Leu Thr Glu Val Pro Glu Met Phe Gly 
    290                 295                 300                 


Ala Glu Thr Leu Leu Met Glu Arg Ala Glu Asn Glu Glu Val Phe His 
305                 310                 315                 320 


Lys Ile Val Arg Leu Ile Asn Asp Phe Lys Gln Tyr Phe Ile Asp His 
                325                 330                 335     


Arg Gln Pro Val Tyr Glu Asn Pro Ser Pro Gly Asn Lys Ala Gly Gly 
            340                 345                 350         


Ile Thr Thr Leu Glu Asp Lys Ser Leu Gly Cys Thr Gln Lys Ala Gly 
        355                 360                 365             


Thr Ser Lys Val Ala Asp Val Leu Glu Tyr Gly Asp Val Leu Lys Lys 
    370                 375                 380                 


Lys Gly Leu Asn Leu Leu Ser Ala Pro Gly Asn Asp Leu Val Ala Ser 
385                 390                 395                 400 


Ser Ala Leu Ala Ala Ala Gly Cys Gln Ile Val Leu Phe Thr Thr Gly 
                405                 410                 415     


Arg Gly Thr Pro Phe Gly Thr Phe Val Pro Thr Met Lys Ile Ser Thr 
            420                 425                 430         


Asn Thr Ala Ile Tyr Glu Ala Lys Arg His Trp Ile Asp Phe Asn Ala 
        435                 440                 445             


Gly Lys Val Leu Glu Asp Arg Ser Glu Asp Asp Val Leu Lys Glu Leu 
    450                 455                 460                 


Thr Ala Tyr Leu Ile Glu Val Ala Ser Gly Arg Gln Leu Asn Asn Glu 
465                 470                 475                 480 


Ile Asn Asp Phe Arg Glu Leu Ala Ile Phe Lys Thr Gly Val Thr Leu 
                485                 490                 495     


<210>  107
<211>  492
<212>  PRT
<213>  Clostridium acetobutylicum

<400>  107

Met Lys Asn Val Ile Lys Ile Asn Glu Lys Asp Asn Val Val Val Ala 
1               5                   10                  15      


Leu Asn Asp Leu Asn Lys Gly Asp Val Ile Glu Ile Asp Gly Lys Val 
            20                  25                  30          


Ile Thr Ala Glu Glu Pro Val Lys Lys Gly His Lys Ile Ala Ile Thr 
        35                  40                  45              


Asp Ile Gln Lys Asn Ser Asn Ile Tyr Lys Tyr Gly Phe Pro Ile Gly 
    50                  55                  60                  


His Ala Leu Glu Glu Ile Lys Lys Gly Gln Trp Val His Thr His Asn 
65                  70                  75                  80  


Ile Lys Thr Asn Leu Asp Gly Ile Lys Asp Tyr Glu Tyr Asn Lys Gln 
                85                  90                  95      


Thr Phe Glu Asn Pro Phe Lys Asn Glu Asn Leu Thr Phe Lys Gly Tyr 
            100                 105                 110         


Arg Arg Glu Asp Gly Thr Val Gly Ile Arg Asn Glu Leu Trp Ile Val 
        115                 120                 125             


Pro Thr Val Gly Cys Val Asn Gly Thr Ala Asp Leu Ile Ala Glu Arg 
    130                 135                 140                 


Phe Lys Ser Glu Thr Glu Phe Lys Asp Val His Val Phe Lys His Asn 
145                 150                 155                 160 


Phe Gly Cys Ser Gln Leu Gly Asp Asp His Asn Asn Thr Arg Thr Ile 
                165                 170                 175     


Leu Gly Asn Ile Val Lys His Pro Asn Ala Gly Gly Val Leu Val Leu 
            180                 185                 190         


Gly Leu Gly Cys Glu Asn Asn Thr Met Glu Ser Phe Lys Glu Ser Leu 
        195                 200                 205             


His Ser Tyr Asn Lys Glu Arg Val Arg Phe Leu Ile Ala Gln Asp Val 
    210                 215                 220                 


Glu Asp Glu Ile Ser Ser Gly Cys Glu Leu Leu Lys Glu Leu Tyr Glu 
225                 230                 235                 240 


Lys Ile Gln Lys Asp Glu Arg Glu Glu Val Ser Ile Ser Glu Leu Lys 
                245                 250                 255     


Ile Gly Leu Lys Cys Gly Ala Ser Asp Gly Phe Ser Gly Ile Thr Ala 
            260                 265                 270         


Asn Pro Leu Leu Gly Lys Leu Ser Asp Phe Leu Ile Ala Gln Gly Gly 
        275                 280                 285             


Thr Thr Ile Leu Thr Glu Val Pro Glu Met Phe Gly Ala Glu Thr Ile 
    290                 295                 300                 


Leu Met Asn Arg Ala Lys Asp Glu Lys Val Phe Ala Lys Thr Val Asn 
305                 310                 315                 320 


Leu Ile Asn Asp Phe Lys Lys Tyr Phe Met Ser Tyr Asn Gln Pro Val 
                325                 330                 335     


Tyr Glu Asn Pro Ser Pro Gly Asn Lys Ala Gly Gly Ile Thr Thr Leu 
            340                 345                 350         


Glu Asp Lys Ser Leu Gly Cys Thr Gln Lys Ser Gly Ser Ser Glu Val 
        355                 360                 365             


Val Gly Val Leu Lys Tyr Gly Glu Thr Leu Glu Asn Lys Gly Leu Asn 
    370                 375                 380                 


Leu Leu Ser Ala Pro Gly Asn Asp Leu Val Ala Ser Thr Ala Leu Ala 
385                 390                 395                 400 


Ser Ala Gly Cys His Met Val Leu Phe Thr Thr Gly Arg Gly Thr Pro 
                405                 410                 415     


Phe Gly Thr Phe Val Pro Thr Val Lys Ile Ser Thr Asn Ser Asp Ile 
            420                 425                 430         


Tyr Asn Lys Lys Lys Asn Trp Ile Asp Phe Asn Ala Gly Ala Leu Leu 
        435                 440                 445             


Glu Asn Gln Ser Met Asp Gln Val Leu Lys Glu Phe Ile Asn Tyr Leu 
    450                 455                 460                 


Leu Gly Val Ala Asn Gly Asn Met Ala Asn Asn Glu Lys Asn Asn Ile 
465                 470                 475                 480 


Arg Glu Ile Ser Ile Phe Lys Asn Gly Val Thr Leu 
                485                 490         


<210>  108
<211>  1536
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 101

<400>  108
ttgcatgagg tgaacaggcg acaaaggagg cggttccgcg tggcgcccag ggttttgcat     60

ctctcgccgg tcgacgatgt cgtggtggcg cttgaaccgc tcgacgtggg ggaggtcgtc    120

gagacccctt tcggccaggt gagcgctcga gcgcccattg cactgggcca caagctcgcc    180

gtcaagcctg tgaagtgcgg agaagcggtg cacaaatacg gttttcccat cggcgtcgca    240

acgcaggaca tcgagccggg cgaatgggtg cacacgcaca atctgcgcac ggcgctctcg    300

gagcgcggct cctacgtgta ccgaccgcac ggttctccgg cactcgtgct tgacgacggc    360

ctcacgttca tgggctatgt ccggtccgac ggacaggtcg gcgtgcgcaa cgagatttgg    420

atcctgaaca cggtcgggtg tgtgaacaaa gtggccgagc ggctagcggc gatggccgac    480

gccaaatggc gcggaggcgg gatcgacggc gtgtaccact tcgcgcatcc gtacgggtgt    540

tcacagctcg gggatgatct cgtctacacc caatctctgc tcgcggggct cgtccgacac    600

cccaacgccg ccggcgtgct tgtgattggg ctcggatgcg agaacaaccg gattgaggcg    660

tttcgggagc ggttggatca agcgtcgctg gagagggtgg cgttcctcga actccagcgc    720

accacggatg aattcgcgga cggcatgcgg ctgttggagg acctcgtcga gcgggcgcgc    780

gcattcgtcc gccagccggt gccagtggct cgtctgaaat tggggctgaa atgcggcgga    840

tccgacggtc tgtcaggcgt cacggcgaat ccactcgtgg gacaggtggc ggaccgcgtc    900

gtcgctcgcg gcggcacggc actcctgacc gaggtgcctg agatgttcgg cgcggagacg    960

gtgctcatgg atcgcgccga cagccctgag acgttcgcca aaatcgtaga tctgattcag   1020

tcgtggaagg attactacac gcgccacggc cagcccgttt atgaaaatcc ctcccccgga   1080

aacaaggcgg gcggcatcac cacactggaa gaaaagtcgc tcggtgccgt gcagaagggc   1140

gggcgccttt cccgggtggt ggacgtcctc ggctacggcg atccggccgt gaaacctggg   1200

ctcaacctga tctcggcgcc tgggaacgac atggtgtcgg tgagcgcgct cgcggcgagc   1260

ggcgcgcagc tgatcctgtt caccacaggc cggggcacgc ccttcggcgg gccggttcca   1320

acgctgaaga ttgcgagcaa ccaccagctt gcgtcgtcga aacctggctg gatcgacttc   1380

gacgcggggc ggatcgcgct cggggaatcg atgaacgatc tcgcggagga attgctgcac   1440

aaggtcattc gcgtggcgtc tggagaagaa ctcgcccgga acgaagtgaa cgggtatcgc   1500

gagatcgcca tcttcaagga cggcgtcacc ctttga                             1536


<210>  109
<211>  1536
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 101

<400>  109
ttgcatgagg tgaacaggcg acaaaggagg cggttccgcg tggcgcccaa ggttttgcat     60

atctcgccgg tcgacgatgt cgtggtggcg cttgaaccgc tcgacgtggg ggaggtcgtc    120

gagacccctt tcggccaggt gagcgctcga gcgcccattg cactgggcca caagctcgcc    180

gtcaagcctg tgaagtgcgg agaagcggtg cacaaatacg gttttcccat cggcgtcgca    240

acgcaggaca tcgagccggg cgaatgggtg cacacgcaca atctgcgcac ggcgctctcg    300

gagcgcggct cctacgtgta ccgaccgcac ggttctccgg cactcgtgct tgacgacggc    360

ctcacgttca tgggctatgt ccggtccgac ggacaggtcg gcgtgcgcaa cgagatttgg    420

atcctgaaca cggtcgggtg tgtgaacaaa gtggccgagc ggctagcggc gatggccgac    480

gccaaatggc gcggaggcgg gatcgacggc gtgtaccact tcgcgcatcc gtacgggtgt    540

tcacagctcg gggatgatct cgtctacacc caatctctgc tcgcggggct cgtccgacac    600

cccaacgccg ccggcgtgct tgtgattggg ctcggatgcg agaacaaccg gattgaggcg    660

tttcgggagc ggttggatca agcgtcgctg gagagggtgg cgttcctcga actccagcgc    720

accacggatg aattcgcgga cggcatgcgg ctgttggagg acctcgtcga gcgggcgcgc    780

gcattcgtcc gccagccggt gccagtggct cgtctgaaat tggggctgaa atgcggcgga    840

tccgacggtc tgtcaggcgt cacggcgaat ccactcgtgg gacaggtggc ggaccgcgtc    900

gtcgctcgcg gcggcacggc actcctgacc gaggtgcctg agatgttcgg cgcggagacg    960

gtgctcatgg atcgcgccga cagccctgag acgttcgcca aaatcgtaga tctgattcag   1020

tcgtggaagg attactacac gcgccacggc cagcccgttt atgaaaatcc ctcccccgga   1080

aacaaggcgg gcggcatcac cacactggaa gaaaagtcgc tcggtgccgt gcagaagggc   1140

gggcgccttt cccgggtggt ggacgtcctc ggctacggcg atccggccgt gaaacctggg   1200

ctcaacctga tctcggcgcc tgggaacgac atggtgtcgg tgagcgcgct cgcggcgagc   1260

ggcgcgcagc tgatcctgtt caccacaggc cggggcacgc ccttcggcgg gccggttcca   1320

acgctgaaga ttgcgagcaa ccaccagctt gcgtcgtcga aacctggctg gatcgacttc   1380

gacgcggggc ggatcgcgct cggggaatcg atgaacgatc tcgcggagga attgctgcac   1440

aaggtcattc gcgtggcgtc tggagaagaa ctcgcccgga acgaagtgaa cgggtatcgc   1500

gagatcgcca tcttcaagga cggcgtcacc ctttga                             1536


<210>  110
<211>  1536
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 101

<400>  110
ttgcatgagg tgaacaggcg acaaaggagg cggttccgcg tggcgcccaa ggttttgcat     60

gtctcgccgg tcgacgatgt cgtggtggcg cttgaaccgc tcgacgtggg ggaggtcgtc    120

gagacccctt tcggccaggt gagcgctcga gcgcccattg cactgggcca caagctcgcc    180

gtcaagcctg tgaagtgcgg agaagcggtg cacaaatacg gttttcccat cggcgtcgca    240

acgcaggaca tcgagccggg cgaatgggtg cacacgcaca atctgcgcac ggcgctctcg    300

gagcgcggct cctacgtgta ccgaccgcac ggttctccgg cactcgtgct tgacgacggc    360

ctcacgttca tgggctatgt ccggtccgac ggacaggtcg gcgtgcgcaa cgagatttgg    420

atcctgaaca cggtcgggtg tgtgaacaaa gtggccgagc ggctagcggc gatggccgac    480

gccaaatggc gcggaggcgg gatcgacggc gtgtaccact tcgcgcatcc gtacgggtgt    540

tcacagctcg gggatgatct cgtctacacc caatctctgc tcgcggggct cgtccgacac    600

cccaacgccg ccggcgtgct tgtgattggg ctcggatgcg agaacaaccg gattgaggcg    660

tttcgggagc ggttggatca agcgtcgctg gagagggtgg cgttcctcga actccagcgc    720

accacggatg aattcgcgga cggcatgcgg ctgttggagg acctcgtcga gcgggcgcgc    780

gcattcgtcc gccagccggt gccagtggct cgtctgaaat tggggctgaa atgcggcgga    840

tccgacggtc tgtcaggcgt cacggcgaat ccactcgtgg gacaggtggc ggaccgcgtc    900

gtcgctcgcg gcggcacggc actcctgacc gaggtgcctg agatgttcgg cgcggagacg    960

gtgctcatgg atcgcgccga cagccctgag acgttcgcca aaatcgtaga tctgattcag   1020

tcgtggaagg attactacac gcgccacggc cagcccgttt atgaaaatcc ctcccccgga   1080

aacaaggcgg gcggcatcac cacactggaa gaaaagtcgc tcggtgccgt gcagaagggc   1140

gggcgccttt cccgggtggt ggacgtcctc ggctacggcg atccggccgt gaaacctggg   1200

ctcaacctga tctcggcgcc tgggaacgac atggtgtcgg tgagcgcgct cgcggcgagc   1260

ggcgcgcagc tgatcctgtt caccacaggc cggggcacgc ccttcggcgg gccggttcca   1320

acgctgaaga ttgcgagcaa ccaccagctt gcgtcgtcga aacctggctg gatcgacttc   1380

gacgcggggc ggatcgcgct cggggaatcg atgaacgatc tcgcggagga attgctgcac   1440

aaggtcattc gcgtggcgtc tggagaagaa ctcgcccgga acgaagtgaa cgggtatcgc   1500

gagatcgcca tcttcaagga cggcgtcacc ctttga                             1536


<210>  111
<211>  1536
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 101

<400>  111
ttgcatgagg tgaacaggcg acaaaggagg cggttccgcg tggcgcccaa ggttttgcat     60

ctctcgccgg tcgacgatgt catagtggcg cttgaaccgc tcgacgtggg ggaggtcgtc    120

gagacccctt tcggccaggt gagcgctcga gcgcccattg cactgggcca caagctcgcc    180

gtcaagcctg tgaagtgcgg agaagcggtg cacaaatacg gttttcccat cggcgtcgca    240

acgcaggaca tcgagccggg cgaatgggtg cacacgcaca atctgcgcac ggcgctctcg    300

gagcgcggct cctacgtgta ccgaccgcac ggttctccgg cactcgtgct tgacgacggc    360

ctcacgttca tgggctatgt ccggtccgac ggacaggtcg gcgtgcgcaa cgagatttgg    420

atcctgaaca cggtcgggtg tgtgaacaaa gtggccgagc ggctagcggc gatggccgac    480

gccaaatggc gcggaggcgg gatcgacggc gtgtaccact tcgcgcatcc gtacgggtgt    540

tcacagctcg gggatgatct cgtctacacc caatctctgc tcgcggggct cgtccgacac    600

cccaacgccg ccggcgtgct tgtgattggg ctcggatgcg agaacaaccg gattgaggcg    660

tttcgggagc ggttggatca agcgtcgctg gagagggtgg cgttcctcga actccagcgc    720

accacggatg aattcgcgga cggcatgcgg ctgttggagg acctcgtcga gcgggcgcgc    780

gcattcgtcc gccagccggt gccagtggct cgtctgaaat tggggctgaa atgcggcgga    840

tccgacggtc tgtcaggcgt cacggcgaat ccactcgtgg gacaggtggc ggaccgcgtc    900

gtcgctcgcg gcggcacggc actcctgacc gaggtgcctg agatgttcgg cgcggagacg    960

gtgctcatgg atcgcgccga cagccctgag acgttcgcca aaatcgtaga tctgattcag   1020

tcgtggaagg attactacac gcgccacggc cagcccgttt atgaaaatcc ctcccccgga   1080

aacaaggcgg gcggcatcac cacactggaa gaaaagtcgc tcggtgccgt gcagaagggc   1140

gggcgccttt cccgggtggt ggacgtcctc ggctacggcg atccggccgt gaaacctggg   1200

ctcaacctga tctcggcgcc tgggaacgac atggtgtcgg tgagcgcgct cgcggcgagc   1260

ggcgcgcagc tgatcctgtt caccacaggc cggggcacgc ccttcggcgg gccggttcca   1320

acgctgaaga ttgcgagcaa ccaccagctt gcgtcgtcga aacctggctg gatcgacttc   1380

gacgcggggc ggatcgcgct cggggaatcg atgaacgatc tcgcggagga attgctgcac   1440

aaggtcattc gcgtggcgtc tggagaagaa ctcgcccgga acgaagtgaa cgggtatcgc   1500

gagatcgcca tcttcaagga cggcgtcacc ctttga                             1536


<210>  112
<211>  1536
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 101

<400>  112
ttgcatgagg tgaacaggcg acaaaggagg cggttccgcg tggcgcccaa ggttttgcat     60

ctctcgccgg tcgacgatgt cctggtggcg cttgaaccgc tcgacgtggg ggaggtcgtc    120

gagacccctt tcggccaggt gagcgctcga gcgcccattg cactgggcca caagctcgcc    180

gtcaagcctg tgaagtgcgg agaagcggtg cacaaatacg gttttcccat cggcgtcgca    240

acgcaggaca tcgagccggg cgaatgggtg cacacgcaca atctgcgcac ggcgctctcg    300

gagcgcggct cctacgtgta ccgaccgcac ggttctccgg cactcgtgct tgacgacggc    360

ctcacgttca tgggctatgt ccggtccgac ggacaggtcg gcgtgcgcaa cgagatttgg    420

atcctgaaca cggtcgggtg tgtgaacaaa gtggccgagc ggctagcggc gatggccgac    480

gccaaatggc gcggaggcgg gatcgacggc gtgtaccact tcgcgcatcc gtacgggtgt    540

tcacagctcg gggatgatct cgtctacacc caatctctgc tcgcggggct cgtccgacac    600

cccaacgccg ccggcgtgct tgtgattggg ctcggatgcg agaacaaccg gattgaggcg    660

tttcgggagc ggttggatca agcgtcgctg gagagggtgg cgttcctcga actccagcgc    720

accacggatg aattcgcgga cggcatgcgg ctgttggagg acctcgtcga gcgggcgcgc    780

gcattcgtcc gccagccggt gccagtggct cgtctgaaat tggggctgaa atgcggcgga    840

tccgacggtc tgtcaggcgt cacggcgaat ccactcgtgg gacaggtggc ggaccgcgtc    900

gtcgctcgcg gcggcacggc actcctgacc gaggtgcctg agatgttcgg cgcggagacg    960

gtgctcatgg atcgcgccga cagccctgag acgttcgcca aaatcgtaga tctgattcag   1020

tcgtggaagg attactacac gcgccacggc cagcccgttt atgaaaatcc ctcccccgga   1080

aacaaggcgg gcggcatcac cacactggaa gaaaagtcgc tcggtgccgt gcagaagggc   1140

gggcgccttt cccgggtggt ggacgtcctc ggctacggcg atccggccgt gaaacctggg   1200

ctcaacctga tctcggcgcc tgggaacgac atggtgtcgg tgagcgcgct cgcggcgagc   1260

ggcgcgcagc tgatcctgtt caccacaggc cggggcacgc ccttcggcgg gccggttcca   1320

acgctgaaga ttgcgagcaa ccaccagctt gcgtcgtcga aacctggctg gatcgacttc   1380

gacgcggggc ggatcgcgct cggggaatcg atgaacgatc tcgcggagga attgctgcac   1440

aaggtcattc gcgtggcgtc tggagaagaa ctcgcccgga acgaagtgaa cgggtatcgc   1500

gagatcgcca tcttcaagga cggcgtcacc ctttga                             1536


<210>  113
<211>  511
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:102 and encoded by SEQ ID NO:108

<400>  113

Met His Glu Val Asn Arg Arg Gln Arg Arg Arg Phe Arg Val Ala Pro 
1               5                   10                  15      


Arg Val Leu His Leu Ser Pro Val Asp Asp Val Val Val Ala Leu Glu 
            20                  25                  30          


Pro Leu Asp Val Gly Glu Val Val Glu Thr Pro Phe Gly Gln Val Ser 
        35                  40                  45              


Ala Arg Ala Pro Ile Ala Leu Gly His Lys Leu Ala Val Lys Pro Val 
    50                  55                  60                  


Lys Cys Gly Glu Ala Val His Lys Tyr Gly Phe Pro Ile Gly Val Ala 
65                  70                  75                  80  


Thr Gln Asp Ile Glu Pro Gly Glu Trp Val His Thr His Asn Leu Arg 
                85                  90                  95      


Thr Ala Leu Ser Glu Arg Gly Ser Tyr Val Tyr Arg Pro His Gly Ser 
            100                 105                 110         


Pro Ala Leu Val Leu Asp Asp Gly Leu Thr Phe Met Gly Tyr Val Arg 
        115                 120                 125             


Ser Asp Gly Gln Val Gly Val Arg Asn Glu Ile Trp Ile Leu Asn Thr 
    130                 135                 140                 


Val Gly Cys Val Asn Lys Val Ala Glu Arg Leu Ala Ala Met Ala Asp 
145                 150                 155                 160 


Ala Lys Trp Arg Gly Gly Gly Ile Asp Gly Val Tyr His Phe Ala His 
                165                 170                 175     


Pro Tyr Gly Cys Ser Gln Leu Gly Asp Asp Leu Val Tyr Thr Gln Ser 
            180                 185                 190         


Leu Leu Ala Gly Leu Val Arg His Pro Asn Ala Ala Gly Val Leu Val 
        195                 200                 205             


Ile Gly Leu Gly Cys Glu Asn Asn Arg Ile Glu Ala Phe Arg Glu Arg 
    210                 215                 220                 


Leu Asp Gln Ala Ser Leu Glu Arg Val Ala Phe Leu Glu Leu Gln Arg 
225                 230                 235                 240 


Thr Thr Asp Glu Phe Ala Asp Gly Met Arg Leu Leu Glu Asp Leu Val 
                245                 250                 255     


Glu Arg Ala Arg Ala Phe Val Arg Gln Pro Val Pro Val Ala Arg Leu 
            260                 265                 270         


Lys Leu Gly Leu Lys Cys Gly Gly Ser Asp Gly Leu Ser Gly Val Thr 
        275                 280                 285             


Ala Asn Pro Leu Val Gly Gln Val Ala Asp Arg Val Val Ala Arg Gly 
    290                 295                 300                 


Gly Thr Ala Leu Leu Thr Glu Val Pro Glu Met Phe Gly Ala Glu Thr 
305                 310                 315                 320 


Val Leu Met Asp Arg Ala Asp Ser Pro Glu Thr Phe Ala Lys Ile Val 
                325                 330                 335     


Asp Leu Ile Gln Ser Trp Lys Asp Tyr Tyr Thr Arg His Gly Gln Pro 
            340                 345                 350         


Val Tyr Glu Asn Pro Ser Pro Gly Asn Lys Ala Gly Gly Ile Thr Thr 
        355                 360                 365             


Leu Glu Glu Lys Ser Leu Gly Ala Val Gln Lys Gly Gly Arg Leu Ser 
    370                 375                 380                 


Arg Val Val Asp Val Leu Gly Tyr Gly Asp Pro Ala Val Lys Pro Gly 
385                 390                 395                 400 


Leu Asn Leu Ile Ser Ala Pro Gly Asn Asp Met Val Ser Val Ser Ala 
                405                 410                 415     


Leu Ala Ala Ser Gly Ala Gln Leu Ile Leu Phe Thr Thr Gly Arg Gly 
            420                 425                 430         


Thr Pro Phe Gly Gly Pro Val Pro Thr Leu Lys Ile Ala Ser Asn His 
        435                 440                 445             


Gln Leu Ala Ser Ser Lys Pro Gly Trp Ile Asp Phe Asp Ala Gly Arg 
    450                 455                 460                 


Ile Ala Leu Gly Glu Ser Met Asn Asp Leu Ala Glu Glu Leu Leu His 
465                 470                 475                 480 


Lys Val Ile Arg Val Ala Ser Gly Glu Glu Leu Ala Arg Asn Glu Val 
                485                 490                 495     


Asn Gly Tyr Arg Glu Ile Ala Ile Phe Lys Asp Gly Val Thr Leu 
            500                 505                 510     


<210>  114
<211>  511
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:102 and encoded by SEQ ID NO:109

<400>  114

Met His Glu Val Asn Arg Arg Gln Arg Arg Arg Phe Arg Val Ala Pro 
1               5                   10                  15      


Lys Val Leu His Ile Ser Pro Val Asp Asp Val Val Val Ala Leu Glu 
            20                  25                  30          


Pro Leu Asp Val Gly Glu Val Val Glu Thr Pro Phe Gly Gln Val Ser 
        35                  40                  45              


Ala Arg Ala Pro Ile Ala Leu Gly His Lys Leu Ala Val Lys Pro Val 
    50                  55                  60                  


Lys Cys Gly Glu Ala Val His Lys Tyr Gly Phe Pro Ile Gly Val Ala 
65                  70                  75                  80  


Thr Gln Asp Ile Glu Pro Gly Glu Trp Val His Thr His Asn Leu Arg 
                85                  90                  95      


Thr Ala Leu Ser Glu Arg Gly Ser Tyr Val Tyr Arg Pro His Gly Ser 
            100                 105                 110         


Pro Ala Leu Val Leu Asp Asp Gly Leu Thr Phe Met Gly Tyr Val Arg 
        115                 120                 125             


Ser Asp Gly Gln Val Gly Val Arg Asn Glu Ile Trp Ile Leu Asn Thr 
    130                 135                 140                 


Val Gly Cys Val Asn Lys Val Ala Glu Arg Leu Ala Ala Met Ala Asp 
145                 150                 155                 160 


Ala Lys Trp Arg Gly Gly Gly Ile Asp Gly Val Tyr His Phe Ala His 
                165                 170                 175     


Pro Tyr Gly Cys Ser Gln Leu Gly Asp Asp Leu Val Tyr Thr Gln Ser 
            180                 185                 190         


Leu Leu Ala Gly Leu Val Arg His Pro Asn Ala Ala Gly Val Leu Val 
        195                 200                 205             


Ile Gly Leu Gly Cys Glu Asn Asn Arg Ile Glu Ala Phe Arg Glu Arg 
    210                 215                 220                 


Leu Asp Gln Ala Ser Leu Glu Arg Val Ala Phe Leu Glu Leu Gln Arg 
225                 230                 235                 240 


Thr Thr Asp Glu Phe Ala Asp Gly Met Arg Leu Leu Glu Asp Leu Val 
                245                 250                 255     


Glu Arg Ala Arg Ala Phe Val Arg Gln Pro Val Pro Val Ala Arg Leu 
            260                 265                 270         


Lys Leu Gly Leu Lys Cys Gly Gly Ser Asp Gly Leu Ser Gly Val Thr 
        275                 280                 285             


Ala Asn Pro Leu Val Gly Gln Val Ala Asp Arg Val Val Ala Arg Gly 
    290                 295                 300                 


Gly Thr Ala Leu Leu Thr Glu Val Pro Glu Met Phe Gly Ala Glu Thr 
305                 310                 315                 320 


Val Leu Met Asp Arg Ala Asp Ser Pro Glu Thr Phe Ala Lys Ile Val 
                325                 330                 335     


Asp Leu Ile Gln Ser Trp Lys Asp Tyr Tyr Thr Arg His Gly Gln Pro 
            340                 345                 350         


Val Tyr Glu Asn Pro Ser Pro Gly Asn Lys Ala Gly Gly Ile Thr Thr 
        355                 360                 365             


Leu Glu Glu Lys Ser Leu Gly Ala Val Gln Lys Gly Gly Arg Leu Ser 
    370                 375                 380                 


Arg Val Val Asp Val Leu Gly Tyr Gly Asp Pro Ala Val Lys Pro Gly 
385                 390                 395                 400 


Leu Asn Leu Ile Ser Ala Pro Gly Asn Asp Met Val Ser Val Ser Ala 
                405                 410                 415     


Leu Ala Ala Ser Gly Ala Gln Leu Ile Leu Phe Thr Thr Gly Arg Gly 
            420                 425                 430         


Thr Pro Phe Gly Gly Pro Val Pro Thr Leu Lys Ile Ala Ser Asn His 
        435                 440                 445             


Gln Leu Ala Ser Ser Lys Pro Gly Trp Ile Asp Phe Asp Ala Gly Arg 
    450                 455                 460                 


Ile Ala Leu Gly Glu Ser Met Asn Asp Leu Ala Glu Glu Leu Leu His 
465                 470                 475                 480 


Lys Val Ile Arg Val Ala Ser Gly Glu Glu Leu Ala Arg Asn Glu Val 
                485                 490                 495     


Asn Gly Tyr Arg Glu Ile Ala Ile Phe Lys Asp Gly Val Thr Leu 
            500                 505                 510     


<210>  115
<211>  511
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:102 and encoded by SEQ ID NO:110

<400>  115

Met His Glu Val Asn Arg Arg Gln Arg Arg Arg Phe Arg Val Ala Pro 
1               5                   10                  15      


Lys Val Leu His Val Ser Pro Val Asp Asp Val Val Val Ala Leu Glu 
            20                  25                  30          


Pro Leu Asp Val Gly Glu Val Val Glu Thr Pro Phe Gly Gln Val Ser 
        35                  40                  45              


Ala Arg Ala Pro Ile Ala Leu Gly His Lys Leu Ala Val Lys Pro Val 
    50                  55                  60                  


Lys Cys Gly Glu Ala Val His Lys Tyr Gly Phe Pro Ile Gly Val Ala 
65                  70                  75                  80  


Thr Gln Asp Ile Glu Pro Gly Glu Trp Val His Thr His Asn Leu Arg 
                85                  90                  95      


Thr Ala Leu Ser Glu Arg Gly Ser Tyr Val Tyr Arg Pro His Gly Ser 
            100                 105                 110         


Pro Ala Leu Val Leu Asp Asp Gly Leu Thr Phe Met Gly Tyr Val Arg 
        115                 120                 125             


Ser Asp Gly Gln Val Gly Val Arg Asn Glu Ile Trp Ile Leu Asn Thr 
    130                 135                 140                 


Val Gly Cys Val Asn Lys Val Ala Glu Arg Leu Ala Ala Met Ala Asp 
145                 150                 155                 160 


Ala Lys Trp Arg Gly Gly Gly Ile Asp Gly Val Tyr His Phe Ala His 
                165                 170                 175     


Pro Tyr Gly Cys Ser Gln Leu Gly Asp Asp Leu Val Tyr Thr Gln Ser 
            180                 185                 190         


Leu Leu Ala Gly Leu Val Arg His Pro Asn Ala Ala Gly Val Leu Val 
        195                 200                 205             


Ile Gly Leu Gly Cys Glu Asn Asn Arg Ile Glu Ala Phe Arg Glu Arg 
    210                 215                 220                 


Leu Asp Gln Ala Ser Leu Glu Arg Val Ala Phe Leu Glu Leu Gln Arg 
225                 230                 235                 240 


Thr Thr Asp Glu Phe Ala Asp Gly Met Arg Leu Leu Glu Asp Leu Val 
                245                 250                 255     


Glu Arg Ala Arg Ala Phe Val Arg Gln Pro Val Pro Val Ala Arg Leu 
            260                 265                 270         


Lys Leu Gly Leu Lys Cys Gly Gly Ser Asp Gly Leu Ser Gly Val Thr 
        275                 280                 285             


Ala Asn Pro Leu Val Gly Gln Val Ala Asp Arg Val Val Ala Arg Gly 
    290                 295                 300                 


Gly Thr Ala Leu Leu Thr Glu Val Pro Glu Met Phe Gly Ala Glu Thr 
305                 310                 315                 320 


Val Leu Met Asp Arg Ala Asp Ser Pro Glu Thr Phe Ala Lys Ile Val 
                325                 330                 335     


Asp Leu Ile Gln Ser Trp Lys Asp Tyr Tyr Thr Arg His Gly Gln Pro 
            340                 345                 350         


Val Tyr Glu Asn Pro Ser Pro Gly Asn Lys Ala Gly Gly Ile Thr Thr 
        355                 360                 365             


Leu Glu Glu Lys Ser Leu Gly Ala Val Gln Lys Gly Gly Arg Leu Ser 
    370                 375                 380                 


Arg Val Val Asp Val Leu Gly Tyr Gly Asp Pro Ala Val Lys Pro Gly 
385                 390                 395                 400 


Leu Asn Leu Ile Ser Ala Pro Gly Asn Asp Met Val Ser Val Ser Ala 
                405                 410                 415     


Leu Ala Ala Ser Gly Ala Gln Leu Ile Leu Phe Thr Thr Gly Arg Gly 
            420                 425                 430         


Thr Pro Phe Gly Gly Pro Val Pro Thr Leu Lys Ile Ala Ser Asn His 
        435                 440                 445             


Gln Leu Ala Ser Ser Lys Pro Gly Trp Ile Asp Phe Asp Ala Gly Arg 
    450                 455                 460                 


Ile Ala Leu Gly Glu Ser Met Asn Asp Leu Ala Glu Glu Leu Leu His 
465                 470                 475                 480 


Lys Val Ile Arg Val Ala Ser Gly Glu Glu Leu Ala Arg Asn Glu Val 
                485                 490                 495     


Asn Gly Tyr Arg Glu Ile Ala Ile Phe Lys Asp Gly Val Thr Leu 
            500                 505                 510     


<210>  116
<211>  511
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:102 and encoded by SEQ ID NO:111

<400>  116

Met His Glu Val Asn Arg Arg Gln Arg Arg Arg Phe Arg Val Ala Pro 
1               5                   10                  15      


Lys Val Leu His Leu Ser Pro Val Asp Asp Val Ile Val Ala Leu Glu 
            20                  25                  30          


Pro Leu Asp Val Gly Glu Val Val Glu Thr Pro Phe Gly Gln Val Ser 
        35                  40                  45              


Ala Arg Ala Pro Ile Ala Leu Gly His Lys Leu Ala Val Lys Pro Val 
    50                  55                  60                  


Lys Cys Gly Glu Ala Val His Lys Tyr Gly Phe Pro Ile Gly Val Ala 
65                  70                  75                  80  


Thr Gln Asp Ile Glu Pro Gly Glu Trp Val His Thr His Asn Leu Arg 
                85                  90                  95      


Thr Ala Leu Ser Glu Arg Gly Ser Tyr Val Tyr Arg Pro His Gly Ser 
            100                 105                 110         


Pro Ala Leu Val Leu Asp Asp Gly Leu Thr Phe Met Gly Tyr Val Arg 
        115                 120                 125             


Ser Asp Gly Gln Val Gly Val Arg Asn Glu Ile Trp Ile Leu Asn Thr 
    130                 135                 140                 


Val Gly Cys Val Asn Lys Val Ala Glu Arg Leu Ala Ala Met Ala Asp 
145                 150                 155                 160 


Ala Lys Trp Arg Gly Gly Gly Ile Asp Gly Val Tyr His Phe Ala His 
                165                 170                 175     


Pro Tyr Gly Cys Ser Gln Leu Gly Asp Asp Leu Val Tyr Thr Gln Ser 
            180                 185                 190         


Leu Leu Ala Gly Leu Val Arg His Pro Asn Ala Ala Gly Val Leu Val 
        195                 200                 205             


Ile Gly Leu Gly Cys Glu Asn Asn Arg Ile Glu Ala Phe Arg Glu Arg 
    210                 215                 220                 


Leu Asp Gln Ala Ser Leu Glu Arg Val Ala Phe Leu Glu Leu Gln Arg 
225                 230                 235                 240 


Thr Thr Asp Glu Phe Ala Asp Gly Met Arg Leu Leu Glu Asp Leu Val 
                245                 250                 255     


Glu Arg Ala Arg Ala Phe Val Arg Gln Pro Val Pro Val Ala Arg Leu 
            260                 265                 270         


Lys Leu Gly Leu Lys Cys Gly Gly Ser Asp Gly Leu Ser Gly Val Thr 
        275                 280                 285             


Ala Asn Pro Leu Val Gly Gln Val Ala Asp Arg Val Val Ala Arg Gly 
    290                 295                 300                 


Gly Thr Ala Leu Leu Thr Glu Val Pro Glu Met Phe Gly Ala Glu Thr 
305                 310                 315                 320 


Val Leu Met Asp Arg Ala Asp Ser Pro Glu Thr Phe Ala Lys Ile Val 
                325                 330                 335     


Asp Leu Ile Gln Ser Trp Lys Asp Tyr Tyr Thr Arg His Gly Gln Pro 
            340                 345                 350         


Val Tyr Glu Asn Pro Ser Pro Gly Asn Lys Ala Gly Gly Ile Thr Thr 
        355                 360                 365             


Leu Glu Glu Lys Ser Leu Gly Ala Val Gln Lys Gly Gly Arg Leu Ser 
    370                 375                 380                 


Arg Val Val Asp Val Leu Gly Tyr Gly Asp Pro Ala Val Lys Pro Gly 
385                 390                 395                 400 


Leu Asn Leu Ile Ser Ala Pro Gly Asn Asp Met Val Ser Val Ser Ala 
                405                 410                 415     


Leu Ala Ala Ser Gly Ala Gln Leu Ile Leu Phe Thr Thr Gly Arg Gly 
            420                 425                 430         


Thr Pro Phe Gly Gly Pro Val Pro Thr Leu Lys Ile Ala Ser Asn His 
        435                 440                 445             


Gln Leu Ala Ser Ser Lys Pro Gly Trp Ile Asp Phe Asp Ala Gly Arg 
    450                 455                 460                 


Ile Ala Leu Gly Glu Ser Met Asn Asp Leu Ala Glu Glu Leu Leu His 
465                 470                 475                 480 


Lys Val Ile Arg Val Ala Ser Gly Glu Glu Leu Ala Arg Asn Glu Val 
                485                 490                 495     


Asn Gly Tyr Arg Glu Ile Ala Ile Phe Lys Asp Gly Val Thr Leu 
            500                 505                 510     


<210>  117
<211>  511
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:102 and encoded by SEQ ID NO:112

<400>  117

Met His Glu Val Asn Arg Arg Gln Arg Arg Arg Phe Arg Val Ala Pro 
1               5                   10                  15      


Lys Val Leu His Leu Ser Pro Val Asp Asp Val Leu Val Ala Leu Glu 
            20                  25                  30          


Pro Leu Asp Val Gly Glu Val Val Glu Thr Pro Phe Gly Gln Val Ser 
        35                  40                  45              


Ala Arg Ala Pro Ile Ala Leu Gly His Lys Leu Ala Val Lys Pro Val 
    50                  55                  60                  


Lys Cys Gly Glu Ala Val His Lys Tyr Gly Phe Pro Ile Gly Val Ala 
65                  70                  75                  80  


Thr Gln Asp Ile Glu Pro Gly Glu Trp Val His Thr His Asn Leu Arg 
                85                  90                  95      


Thr Ala Leu Ser Glu Arg Gly Ser Tyr Val Tyr Arg Pro His Gly Ser 
            100                 105                 110         


Pro Ala Leu Val Leu Asp Asp Gly Leu Thr Phe Met Gly Tyr Val Arg 
        115                 120                 125             


Ser Asp Gly Gln Val Gly Val Arg Asn Glu Ile Trp Ile Leu Asn Thr 
    130                 135                 140                 


Val Gly Cys Val Asn Lys Val Ala Glu Arg Leu Ala Ala Met Ala Asp 
145                 150                 155                 160 


Ala Lys Trp Arg Gly Gly Gly Ile Asp Gly Val Tyr His Phe Ala His 
                165                 170                 175     


Pro Tyr Gly Cys Ser Gln Leu Gly Asp Asp Leu Val Tyr Thr Gln Ser 
            180                 185                 190         


Leu Leu Ala Gly Leu Val Arg His Pro Asn Ala Ala Gly Val Leu Val 
        195                 200                 205             


Ile Gly Leu Gly Cys Glu Asn Asn Arg Ile Glu Ala Phe Arg Glu Arg 
    210                 215                 220                 


Leu Asp Gln Ala Ser Leu Glu Arg Val Ala Phe Leu Glu Leu Gln Arg 
225                 230                 235                 240 


Thr Thr Asp Glu Phe Ala Asp Gly Met Arg Leu Leu Glu Asp Leu Val 
                245                 250                 255     


Glu Arg Ala Arg Ala Phe Val Arg Gln Pro Val Pro Val Ala Arg Leu 
            260                 265                 270         


Lys Leu Gly Leu Lys Cys Gly Gly Ser Asp Gly Leu Ser Gly Val Thr 
        275                 280                 285             


Ala Asn Pro Leu Val Gly Gln Val Ala Asp Arg Val Val Ala Arg Gly 
    290                 295                 300                 


Gly Thr Ala Leu Leu Thr Glu Val Pro Glu Met Phe Gly Ala Glu Thr 
305                 310                 315                 320 


Val Leu Met Asp Arg Ala Asp Ser Pro Glu Thr Phe Ala Lys Ile Val 
                325                 330                 335     


Asp Leu Ile Gln Ser Trp Lys Asp Tyr Tyr Thr Arg His Gly Gln Pro 
            340                 345                 350         


Val Tyr Glu Asn Pro Ser Pro Gly Asn Lys Ala Gly Gly Ile Thr Thr 
        355                 360                 365             


Leu Glu Glu Lys Ser Leu Gly Ala Val Gln Lys Gly Gly Arg Leu Ser 
    370                 375                 380                 


Arg Val Val Asp Val Leu Gly Tyr Gly Asp Pro Ala Val Lys Pro Gly 
385                 390                 395                 400 


Leu Asn Leu Ile Ser Ala Pro Gly Asn Asp Met Val Ser Val Ser Ala 
                405                 410                 415     


Leu Ala Ala Ser Gly Ala Gln Leu Ile Leu Phe Thr Thr Gly Arg Gly 
            420                 425                 430         


Thr Pro Phe Gly Gly Pro Val Pro Thr Leu Lys Ile Ala Ser Asn His 
        435                 440                 445             


Gln Leu Ala Ser Ser Lys Pro Gly Trp Ile Asp Phe Asp Ala Gly Arg 
    450                 455                 460                 


Ile Ala Leu Gly Glu Ser Met Asn Asp Leu Ala Glu Glu Leu Leu His 
465                 470                 475                 480 


Lys Val Ile Arg Val Ala Ser Gly Glu Glu Leu Ala Arg Asn Glu Val 
                485                 490                 495     


Asn Gly Tyr Arg Glu Ile Ala Ile Phe Lys Asp Gly Val Thr Leu 
            500                 505                 510     


<210>  118
<211>  1086
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  118
gtgcggtatg aggaggtgtc tccattgtcc aagtacgtga gcgtgttcaa gcagttgctc     60

gaagcgcacg gcgggccagg cttcgaggag gacgtgcgca acctcattct ccctcatcta    120

tcggaatacg cgacggagat gtggaccgac gcgctcggca acctcatcgg cctcgtcccg    180

ggtgtgggag aagggcggcg gccgcgggtg ctcgtgtccg cacacatcga cgaaattgca    240

ctggtcgtca cccgcatcga atcgggcgga tttctgcgtc tcgcgcaggc ggggggattc    300

gatccgcgga cgctcgtcgg ccaagaggtc gtggttcacg cccaaagcgg ccgggtctgg    360

ggcgtcatcg gggccaaacc gccgcacctc acgcctcctt ccgagcggtc gaaagccgcg    420

aaactcgaag atctgtacgt cgatctcgcc ctccctgagg aggaggtgcg cgcgcgcgtc    480

cgggtgggcg atcgcgtcac gcttcgccgc tcgcccgtcg atctgctcaa cggccggatc    540

gcgggcaaat cggtcgacaa ccgggcgagt gcagccgttc tgttggaggc gctcgccttg    600

ctgaagggca tggtgcacag cgcggatctc tacgccgtgt ttacggtgca ggaggaggtc    660

ggcctgcggg gggccagaac ggctggattt ggcctggcgc ccgacatcgc cattgccgtg    720

gacgtcacct tcggggcgtt tcccgggcag gcgccggatg agtcgtttcc gctcgaaggc    780

ggtgtcgcca tctccttcgg ccccaacctc caccggcggg tgtttcggcg cctcgtggac    840

tgcgccgaca ggcatcgcat cccgtatcag atcgagctgt cgcaggggcc ggtgggcgcg    900

gacgccaacg catttcaaat tgccggcccc ggcctcgcgg cggcgctcat cggtccgccg    960

attcggtaca tgcacacgtc ggtcgaaacc gtcgcttacg acgacatttg gcagtgcgcg   1020

cgactcctcg cccattactt ggcggaggtc gacgccgcgc aggtggagga gttgacatgt   1080

tactga                                                              1086


<210>  119
<211>  361
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  119

Met Arg Tyr Glu Glu Val Ser Pro Leu Ser Lys Tyr Val Ser Val Phe 
1               5                   10                  15      


Lys Gln Leu Leu Glu Ala His Gly Gly Pro Gly Phe Glu Glu Asp Val 
            20                  25                  30          


Arg Asn Leu Ile Leu Pro His Leu Ser Glu Tyr Ala Thr Glu Met Trp 
        35                  40                  45              


Thr Asp Ala Leu Gly Asn Leu Ile Gly Leu Val Pro Gly Val Gly Glu 
    50                  55                  60                  


Gly Arg Arg Pro Arg Val Leu Val Ser Ala His Ile Asp Glu Ile Ala 
65                  70                  75                  80  


Leu Val Val Thr Arg Ile Glu Ser Gly Gly Phe Leu Arg Leu Ala Gln 
                85                  90                  95      


Ala Gly Gly Phe Asp Pro Arg Thr Leu Val Gly Gln Glu Val Val Val 
            100                 105                 110         


His Ala Gln Ser Gly Arg Val Trp Gly Val Ile Gly Ala Lys Pro Pro 
        115                 120                 125             


His Leu Thr Pro Pro Ser Glu Arg Ser Lys Ala Ala Lys Leu Glu Asp 
    130                 135                 140                 


Leu Tyr Val Asp Leu Ala Leu Pro Glu Glu Glu Val Arg Ala Arg Val 
145                 150                 155                 160 


Arg Val Gly Asp Arg Val Thr Leu Arg Arg Ser Pro Val Asp Leu Leu 
                165                 170                 175     


Asn Gly Arg Ile Ala Gly Lys Ser Val Asp Asn Arg Ala Ser Ala Ala 
            180                 185                 190         


Val Leu Leu Glu Ala Leu Ala Leu Leu Lys Gly Met Val His Ser Ala 
        195                 200                 205             


Asp Leu Tyr Ala Val Phe Thr Val Gln Glu Glu Val Gly Leu Arg Gly 
    210                 215                 220                 


Ala Arg Thr Ala Gly Phe Gly Leu Ala Pro Asp Ile Ala Ile Ala Val 
225                 230                 235                 240 


Asp Val Thr Phe Gly Ala Phe Pro Gly Gln Ala Pro Asp Glu Ser Phe 
                245                 250                 255     


Pro Leu Glu Gly Gly Val Ala Ile Ser Phe Gly Pro Asn Leu His Arg 
            260                 265                 270         


Arg Val Phe Arg Arg Leu Val Asp Cys Ala Asp Arg His Arg Ile Pro 
        275                 280                 285             


Tyr Gln Ile Glu Leu Ser Gln Gly Pro Val Gly Ala Asp Ala Asn Ala 
    290                 295                 300                 


Phe Gln Ile Ala Gly Pro Gly Leu Ala Ala Ala Leu Ile Gly Pro Pro 
305                 310                 315                 320 


Ile Arg Tyr Met His Thr Ser Val Glu Thr Val Ala Tyr Asp Asp Ile 
                325                 330                 335     


Trp Gln Cys Ala Arg Leu Leu Ala His Tyr Leu Ala Glu Val Asp Ala 
            340                 345                 350         


Ala Gln Val Glu Glu Leu Thr Cys Tyr 
        355                 360     


<210>  120
<211>  349
<212>  PRT
<213>  Clostridium thermocellum

<400>  120

Met Asp Tyr Ile Asn Ile Leu Lys Asp Leu Ser Thr Tyr Pro Gly Val 
1               5                   10                  15      


Ser Gly Gln Glu Asp Lys Leu Ser Gly Tyr Ile Ala Lys Leu Phe Glu 
            20                  25                  30          


Lys Tyr Cys Asp Ser Val Glu Ile Asp Glu Phe Tyr Asn Val Ile Gly 
        35                  40                  45              


Ile Lys Lys Gly Ile Gly Gly Ser Gly Gly Arg Arg Ile Met Val Thr 
    50                  55                  60                  


Ala His Leu Asp Glu Ile Gly Leu Met Val Lys Ser Ile Asp Glu Lys 
65                  70                  75                  80  


Gly Phe Ile Thr Val Ser Asn Ile Gly Gly Val Asp Ser Lys Val Leu 
                85                  90                  95      


Leu Ala Gln Glu Val Val Ile His Gly Lys Lys Glu Ile Tyr Gly Ile 
            100                 105                 110         


Ile Gly Ala Lys Pro Pro His Leu Leu Thr Pro Glu Glu Ile Lys Lys 
        115                 120                 125             


Ala Val Lys Met Glu Asp Leu Val Ile Asp Thr Gly Leu Ser Ala Glu 
    130                 135                 140                 


Glu Val Arg Lys Tyr Val Ser Val Gly Asp Ile Val Thr Phe Lys Val 
145                 150                 155                 160 


Glu Pro Leu Val Leu Gln Asn Asn Arg Phe Ser Ser Lys Ser Leu Asp 
                165                 170                 175     


Asn Arg Ala Gly Val Val Ala Leu Leu Asp Ile Met Glu Asn Leu Thr 
            180                 185                 190         


Leu Leu Asn His Lys Asp Asp Val Trp Phe Val Ala Thr Val Gln Glu 
        195                 200                 205             


Glu Val Gly Leu Arg Gly Ala Asn Ile Ala Ala Tyr Asn Ile Asn Pro 
    210                 215                 220                 


Asp Leu Ala Ile Val Ile Asp Val Cys His Gly Gln Ile Pro Gly Thr 
225                 230                 235                 240 


Pro Lys Glu Ser Val Phe Pro Val Gly Lys Gly Pro Ala Val Ala Val 
                245                 250                 255     


Gly Pro Asn Leu His Arg Lys Tyr Thr Lys Lys Met Ile Glu Leu Ala 
            260                 265                 270         


Lys Glu Glu Asn Ile Pro Tyr Gln Ile Asp Val Glu Pro Gly Asp Thr 
        275                 280                 285             


Gly Thr Glu Ala Trp Ala Val Gln Val Ser Arg Glu Gly Ile Pro Thr 
    290                 295                 300                 


Leu Leu Val Ser Ile Pro Leu Lys Tyr Met His Thr Val Ile Glu Thr 
305                 310                 315                 320 


Leu Ser Ile Asp Asp Ile Lys Asn Thr Gly Arg Leu Ile Ala Arg Phe 
                325                 330                 335     


Ile Ser Met Thr Gly Asn Glu Met Glu Glu Gly Leu Cys 
            340                 345                 


<210>  121
<211>  346
<212>  PRT
<213>  Thermoanaerobacter ethanolicus

<400>  121

Met Asp Tyr Lys Asp Leu Leu Lys Lys Leu Ser Glu Asn His Gly Val 
1               5                   10                  15      


Ser Gly His Glu Arg Gly Ile Tyr Asp Leu Leu Lys Lys Glu Phe Glu 
            20                  25                  30          


Pro Ile Ser Asp Glu Val Lys Glu Asp Asn Phe Gly Asn Leu Ile Phe 
        35                  40                  45              


Lys Lys Lys Gly Thr Lys Gly Lys Tyr Lys Val Met Leu Ala Ala His 
    50                  55                  60                  


Leu Asp Glu Ile Gly Leu Met Val Lys Asp Ile Asp Glu Lys Gly Phe 
65                  70                  75                  80  


Ile Lys Phe Thr Pro Val Gly Gly Val Asp Gln Arg Thr Leu Pro Ser 
                85                  90                  95      


Gln Glu Val Ile Val His Gly Lys Lys Glu Leu Leu Gly Val Ile Gly 
            100                 105                 110         


Ser Lys Pro Pro His Leu Leu Ser Ser Glu Asp Met Lys Lys Ala Ile 
        115                 120                 125             


Lys Ile Asp Asp Met Tyr Val Asp Val Gly Leu Pro Lys Glu Glu Val 
    130                 135                 140                 


Glu Lys Leu Val Ser Ile Gly Asp Ile Ile Thr Val Lys Arg Glu Phe 
145                 150                 155                 160 


Lys Glu Leu Leu Asn Glu Asn Val Ser Gly Lys Ala Leu Asp Asp Arg 
                165                 170                 175     


Ala Gly Val Val Val Met Ala Val Cys Leu Glu Glu Leu Lys Lys Val 
            180                 185                 190         


Tyr His Tyr His Asp Val Tyr Ala Val Val Thr Leu Gln Glu Glu Val 
        195                 200                 205             


Gly Val Arg Gly Ala Thr Thr Ser Ser Tyr Asn Ile Glu Pro Asp Ile 
    210                 215                 220                 


Ala Ile Ala Ile Asp Val Thr His Ala Lys Ala Arg Gly Val Ser Arg 
225                 230                 235                 240 


Asp Ile Glu Ile Gly Lys Gly Pro Ala Ile Gly Lys Gly Pro Asn Ile 
                245                 250                 255     


His Pro Ala Val Tyr Lys Gly Leu Val Asp Ile Ala Lys Lys Tyr Asn 
            260                 265                 270         


Ile Asn Tyr Gln Ile Glu Pro Leu Pro Gly His Ser Gly Thr Asp Ala 
        275                 280                 285             


Trp Ala Ile Gln Val Ser Lys Lys Gly Val Pro Thr Gly Leu Val Ser 
    290                 295                 300                 


Ile Pro Leu Lys Tyr Met His Thr Ser Val Glu Thr Ala Asn Met Lys 
305                 310                 315                 320 


Asp Ile Ile Glu Ser Gly Arg Leu Leu Ala His Tyr Ile Ala Asn Leu 
                325                 330                 335     


Pro Glu Glu Leu Glu Gly His Leu Cys Tyr 
            340                 345     


<210>  122
<211>  346
<212>  PRT
<213>  Thermoanaerobacter tengcongensis 

<400>  122

Met Asp Tyr Lys Glu Leu Leu Lys Lys Leu Ser Glu Ser His Gly Val 
1               5                   10                  15      


Ser Gly His Glu Arg Gly Ile Tyr Gln Leu Leu Lys Lys Glu Phe Glu 
            20                  25                  30          


Glu Ile Ser Asp Glu Val Leu Glu Asp Asn Phe Gly Asn Leu Ile Phe 
        35                  40                  45              


Lys Lys Lys Gly Leu Lys Gly Lys Tyr Lys Val Met Leu Ala Ala His 
    50                  55                  60                  


Leu Asp Glu Ile Gly Leu Met Val Lys Asp Ile Asp Glu Lys Gly Phe 
65                  70                  75                  80  


Ile Lys Phe Thr Pro Val Gly Gly Val Asp Gln Arg Thr Leu Pro Ser 
                85                  90                  95      


Gln Glu Val Ile Val His Gly Lys Lys Glu Leu Leu Gly Val Ile Gly 
            100                 105                 110         


Ser Lys Pro Pro His Leu Leu Ser Ser Glu Asp Met Glu Lys Ala Ile 
        115                 120                 125             


Lys Ile Asp Asp Met Tyr Val Asp Val Gly Leu Pro Lys Glu Glu Val 
    130                 135                 140                 


Glu Lys Leu Val Ser Ile Gly Asp Ile Ile Thr Val Lys Arg Glu Phe 
145                 150                 155                 160 


Arg Glu Leu Leu Asn Asp Asn Val Ser Gly Lys Ala Leu Asp Asp Arg 
                165                 170                 175     


Ala Gly Val Val Val Met Ala Val Cys Leu Asp Glu Leu Arg Lys Met 
            180                 185                 190         


Tyr His Tyr His Asp Val Tyr Ala Val Ala Thr Leu Gln Glu Glu Val 
        195                 200                 205             


Gly Val Arg Gly Ala Ile Thr Ser Ser Tyr Asn Ile Glu Pro Asp Ile 
    210                 215                 220                 


Ala Ile Ala Ile Asp Val Thr His Ala Lys Ala Arg Gly Val Ser Arg 
225                 230                 235                 240 


Asp Ile Glu Ile Gly Lys Gly Pro Ala Ile Gly Lys Gly Pro Asn Ile 
                245                 250                 255     


His Pro Ala Val Tyr Lys Gly Leu Val Asp Ile Ala Lys Lys Tyr Asn 
            260                 265                 270         


Ile Asn Tyr Gln Ile Glu Pro Leu Pro Gly His Ser Gly Thr Asp Ala 
        275                 280                 285             


Trp Ala Ile Gln Val Ser Lys Lys Gly Val Pro Thr Gly Leu Val Ser 
    290                 295                 300                 


Ile Pro Leu Lys Tyr Met His Thr Ser Val Glu Thr Ala Asn Met Lys 
305                 310                 315                 320 


Asp Ile Ile Glu Ser Gly Arg Leu Leu Ala His Tyr Ile Ala Asn Leu 
                325                 330                 335     


Pro Glu Glu Leu Glu Gly His Leu Cys Tyr 
            340                 345     


<210>  123
<211>  346
<212>  PRT
<213>  Thermoanaerobacter ethanolicus

<400>  123

Met Asp Tyr Lys Asp Leu Leu Lys Lys Leu Ser Glu Ser Tyr Gly Val 
1               5                   10                  15      


Ser Gly His Glu Arg Gly Ile Tyr Asp Leu Leu Lys Lys Glu Phe Glu 
            20                  25                  30          


Pro Ile Ser Asp Glu Val Lys Glu Asp Asn Phe Gly Asn Leu Ile Phe 
        35                  40                  45              


Lys Lys Lys Gly Thr Lys Gly Lys Tyr Lys Val Met Leu Ala Ala His 
    50                  55                  60                  


Leu Asp Glu Ile Gly Leu Met Val Lys Asp Ile Asp Glu Lys Gly Phe 
65                  70                  75                  80  


Ile Lys Phe Thr Thr Val Gly Gly Val Asp Gln Arg Thr Leu Pro Ser 
                85                  90                  95      


Gln Glu Val Ile Val His Gly Lys Lys Asp Leu Leu Gly Val Ile Gly 
            100                 105                 110         


Ser Lys Pro Pro His Leu Leu Ser Ser Glu Asp Met Glu Lys Ala Ile 
        115                 120                 125             


Lys Ile Asp Asp Met Tyr Val Asp Val Gly Leu Pro Lys Lys Glu Val 
    130                 135                 140                 


Glu Glu Leu Val Lys Ile Gly Asp Ile Ile Thr Ile Lys Arg Asp Phe 
145                 150                 155                 160 


Arg Glu Leu Leu Asn Asp Tyr Val Ser Gly Lys Ala Leu Asp Asp Arg 
                165                 170                 175     


Ala Gly Ile Val Val Met Ala Val Cys Leu Asp Glu Leu Lys Lys Leu 
            180                 185                 190         


Tyr His Tyr His Asp Val Tyr Ala Val Val Thr Leu Gln Glu Glu Val 
        195                 200                 205             


Gly Val Arg Gly Ala Thr Thr Ser Ala Tyr Asn Val Glu Pro Asp Ile 
    210                 215                 220                 


Ala Ile Ala Ile Asp Val Thr His Gly Lys Ala Arg Gly Val Ser Leu 
225                 230                 235                 240 


Glu Ile Glu Leu Gly Lys Gly Pro Ala Ile Gly Lys Gly Pro Asn Ile 
                245                 250                 255     


His Pro Ala Val Tyr Lys Gly Leu Val Glu Ala Ala Lys Asn Tyr Asn 
            260                 265                 270         


Ile Asn Tyr Gln Val Glu Pro Leu Pro Gly Pro Ser Gly Thr Asp Ala 
        275                 280                 285             


Trp Ala Ile Gln Val Ser Arg Glu Gly Val Pro Thr Gly Leu Val Ser 
    290                 295                 300                 


Ile Pro Leu Arg Tyr Met His Thr Ser Val Glu Thr Ala Asn Met Lys 
305                 310                 315                 320 


Asp Val Ile Ser Ser Gly Lys Leu Leu Ala Tyr Tyr Ile Ala Asn Leu 
                325                 330                 335     


Pro Glu Glu Leu Glu Gly His Leu Cys Tyr 
            340                 345     


<210>  124
<211>  346
<212>  PRT
<213>  Thermoanaerobacter ethanolicus 

<400>  124

Met Asp Tyr Lys Asn Leu Leu Lys Lys Leu Cys Glu Ser His Gly Val 
1               5                   10                  15      


Ser Gly His Glu Arg Gly Ile Tyr Asp Leu Val Lys Glu Glu Phe Ala 
            20                  25                  30          


Gln Ile Ser Asp Glu Val Thr Glu Asp Lys Phe Gly Asn Leu Phe Phe 
        35                  40                  45              


Leu Lys Lys Gly Thr Lys Gly Lys Tyr Lys Val Met Leu Ala Ala His 
    50                  55                  60                  


Leu Asp Glu Ile Gly Leu Ile Val Lys Asp Ile Asp Asp Lys Gly Phe 
65                  70                  75                  80  


Ile Lys Phe Thr Thr Val Gly Gly Ile Asp Gln Arg Thr Leu Pro Ser 
                85                  90                  95      


Gln Glu Val Ile Val His Gly Lys Lys Asp Ile Leu Gly Val Ile Gly 
            100                 105                 110         


Ser Lys Pro Pro His Leu Leu Ser Leu Gly Asp Met Glu Lys Ala Ile 
        115                 120                 125             


Lys Ile Glu Asp Met Tyr Ile Asp Val Gly Met Ser Lys Lys Glu Val 
    130                 135                 140                 


Glu Glu Leu Val Lys Ile Gly Asp Val Ile Thr Ile Lys Arg Glu Phe 
145                 150                 155                 160 


Arg Glu Leu Leu Asn Asp Tyr Val Ser Gly Lys Ala Leu Asp Asp Arg 
                165                 170                 175     


Ala Gly Ile Ala Val Met Ala Val Cys Leu Glu Glu Leu Asn Lys Leu 
            180                 185                 190         


Tyr His Tyr His Asp Val Tyr Ala Val Ala Thr Leu Gln Glu Glu Val 
        195                 200                 205             


Gly Val Arg Gly Ala Ile Thr Ser Ala Tyr Asn Val Glu Pro Asp Ile 
    210                 215                 220                 


Ala Ile Ala Ile Asp Val Thr His Gly Lys Ala Arg Gly Leu Ser Ile 
225                 230                 235                 240 


Glu Ile Glu Leu Gly Lys Gly Pro Ala Ile Gly Lys Gly Pro Asn Met 
                245                 250                 255     


His Pro Ala Val Tyr Lys Gly Leu Val Glu Ala Ala Lys Ser Tyr Asn 
            260                 265                 270         


Ile Asn Tyr Gln Val Glu Pro Leu Pro Gly Pro Ser Gly Thr Asp Ala 
        275                 280                 285             


Trp Ala Ile Gln Ile Ser Lys Asp Gly Val Pro Thr Gly Leu Val Ser 
    290                 295                 300                 


Ile Pro Leu Arg Tyr Met His Thr Ser Val Glu Thr Ala Asn Met Lys 
305                 310                 315                 320 


Asp Ile Ile Asn Ser Gly Lys Leu Leu Ala Tyr Tyr Ile Ala Asn Leu 
                325                 330                 335     


Pro Glu Glu Leu Glu Gly His Leu Cys Tyr 
            340                 345     


<210>  125
<211>  1086
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 118

<400>  125
gtgaagtatg aggaggtgtc tccattgtcc aagtacgtga gcgtgttcaa gcagttgctc     60

gaagcgcacg gcgggccagg cttcgaggag gacgtgcgca acctcattct ccctcatcta    120

tcggaatacg cgacggagat gtggaccgac gcgctcggca acctcatcgg cctcgtcccg    180

ggtgtgggag aagggcggcg gccgcgggtg ctcgtgtccg cacacatcga cgaaattgca    240

ctggtcgtca cccgcatcga atcgggcgga tttctgcgtc tcgcgcaggc ggggggattc    300

gatccgcgga cgctcgtcgg ccaagaggtc gtggttcacg cccaaagcgg ccgggtctgg    360

ggcgtcatcg gggccaaacc gccgcacctc acgcctcctt ccgagcggtc gaaagccgcg    420

aaactcgaag atctgtacgt cgatctcgcc ctccctgagg aggaggtgcg cgcgcgcgtc    480

cgggtgggcg atcgcgtcac gcttcgccgc tcgcccgtcg atctgctcaa cggccggatc    540

gcgggcaaat cggtcgacaa ccgggcgagt gcagccgttc tgttggaggc gctcgccttg    600

ctgaagggca tggtgcacag cgcggatctc tacgccgtgt ttacggtgca ggaggaggtc    660

ggcctgcggg gggccagaac ggctggattt ggcctggcgc ccgacatcgc cattgccgtg    720

gacgtcacct tcggggcgtt tcccgggcag gcgccggatg agtcgtttcc gctcgaaggc    780

ggtgtcgcca tctccttcgg ccccaacctc caccggcggg tgtttcggcg cctcgtggac    840

tgcgccgaca ggcatcgcat cccgtatcag atcgagctgt cgcaggggcc ggtgggcgcg    900

gacgccaacg catttcaaat tgccggcccc ggcctcgcgg cggcgctcat cggtccgccg    960

attcggtaca tgcacacgtc ggtcgaaacc gtcgcttacg acgacatttg gcagtgcgcg   1020

cgactcctcg cccattactt ggcggaggtc gacgccgcgc aggtggagga gttgacatgt   1080

tactga                                                              1086


<210>  126
<211>  1080
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 118

<400>  126
gtgcggtatg aggagatatc tccattgtcc aagtacgtga gcgtgttcaa gcagttgctc     60

gaagcgcacg gcgggccagg cttcgaggag gacgtgcgca acctcattct ccctcatcta    120

tcggaatacg cgacggagat gtggaccgac gcgctcggca acctcatcgg cctcgtcccg    180

ggtgtgggag aagggcggcg gccgcgggtg ctcgtgtccg cacacatcga cgaaattgca    240

ctggtcgtca cccgcatcga atcgggcgga tttctgcgtc tcgcgcaggc ggggggattc    300

gatccgcgga cgctcgtcgg ccaagaggtc gtggttcacg cccaaagcgg ccgggtctgg    360

ggcgtcatcg gggccaaacc gccgcacctc acgcctcctt ccgagcggtc gaaagccgcg    420

aaactcgaag atctgtacgt cgatctcgcc ctccctgagg aggaggtgcg cgcgcgcgtc    480

cgggtgggcg atcgcgtcac gcttcgccgc tcgcccgtcg atctgctcaa cggccggatc    540

gcgggcaaat cggtcgacaa ccgggcgagt gcagccgttc tgttggaggc gctcgccttg    600

ctgaagggca tggtgcacag cgcggatctc tacgccgtgt ttacggtgca ggaggaggtc    660

ggcctgcggg gggccagaac ggctggattt ggcctggcgc ccgacatcgc cattgccgtg    720

gacgtcacct tcggggcgtt tcccgggcag gcgccggatg agtcgtttcc gctcgaaggc    780

ggtgtcgcca tctccttcgg ccccaacctc caccggcggg tgtttcggcg cctcgtggac    840

tgcgccgaca ggcatcgcat cccgtatcag atcgagctgt cgcaggggcc ggtgggcgcg    900

gacgccaacg catttcaaat tgccggcccc ggcctcgcgg cggcgctcat cggtccgccg    960

attcggtaca tgcacacgtc ggtcgaaacc gtcgcttacg acgacatttg gcagtgcgcg   1020

cgactcctcg cccattactt ggcggaggtc gacgccgcgc aggtggagga gttgacatgt   1080


<210>  127
<211>  1086
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 118

<400>  127
gtgcggtatg aggagctgtc tccattgtcc aagtacgtga gcgtgttcaa gcagttgctc     60

gaagcgcacg gcgggccagg cttcgaggag gacgtgcgca acctcattct ccctcatcta    120

tcggaatacg cgacggagat gtggaccgac gcgctcggca acctcatcgg cctcgtcccg    180

ggtgtgggag aagggcggcg gccgcgggtg ctcgtgtccg cacacatcga cgaaattgca    240

ctggtcgtca cccgcatcga atcgggcgga tttctgcgtc tcgcgcaggc ggggggattc    300

gatccgcgga cgctcgtcgg ccaagaggtc gtggttcacg cccaaagcgg ccgggtctgg    360

ggcgtcatcg gggccaaacc gccgcacctc acgcctcctt ccgagcggtc gaaagccgcg    420

aaactcgaag atctgtacgt cgatctcgcc ctccctgagg aggaggtgcg cgcgcgcgtc    480

cgggtgggcg atcgcgtcac gcttcgccgc tcgcccgtcg atctgctcaa cggccggatc    540

gcgggcaaat cggtcgacaa ccgggcgagt gcagccgttc tgttggaggc gctcgccttg    600

ctgaagggca tggtgcacag cgcggatctc tacgccgtgt ttacggtgca ggaggaggtc    660

ggcctgcggg gggccagaac ggctggattt ggcctggcgc ccgacatcgc cattgccgtg    720

gacgtcacct tcggggcgtt tcccgggcag gcgccggatg agtcgtttcc gctcgaaggc    780

ggtgtcgcca tctccttcgg ccccaacctc caccggcggg tgtttcggcg cctcgtggac    840

tgcgccgaca ggcatcgcat cccgtatcag atcgagctgt cgcaggggcc ggtgggcgcg    900

gacgccaacg catttcaaat tgccggcccc ggcctcgcgg cggcgctcat cggtccgccg    960

attcggtaca tgcacacgtc ggtcgaaacc gtcgcttacg acgacatttg gcagtgcgcg   1020

cgactcctcg cccattactt ggcggaggtc gacgccgcgc aggtggagga gttgacatgt   1080

tactga                                                              1086


<210>  128
<211>  1086
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 118

<400>  128
gtgcggtatg aggaggtgtc tccaatatcc aagtacgtga gcgtgttcaa gcagttgctc     60

gaagcgcacg gcgggccagg cttcgaggag gacgtgcgca acctcattct ccctcatcta    120

tcggaatacg cgacggagat gtggaccgac gcgctcggca acctcatcgg cctcgtcccg    180

ggtgtgggag aagggcggcg gccgcgggtg ctcgtgtccg cacacatcga cgaaattgca    240

ctggtcgtca cccgcatcga atcgggcgga tttctgcgtc tcgcgcaggc ggggggattc    300

gatccgcgga cgctcgtcgg ccaagaggtc gtggttcacg cccaaagcgg ccgggtctgg    360

ggcgtcatcg gggccaaacc gccgcacctc acgcctcctt ccgagcggtc gaaagccgcg    420

aaactcgaag atctgtacgt cgatctcgcc ctccctgagg aggaggtgcg cgcgcgcgtc    480

cgggtgggcg atcgcgtcac gcttcgccgc tcgcccgtcg atctgctcaa cggccggatc    540

gcgggcaaat cggtcgacaa ccgggcgagt gcagccgttc tgttggaggc gctcgccttg    600

ctgaagggca tggtgcacag cgcggatctc tacgccgtgt ttacggtgca ggaggaggtc    660

ggcctgcggg gggccagaac ggctggattt ggcctggcgc ccgacatcgc cattgccgtg    720

gacgtcacct tcggggcgtt tcccgggcag gcgccggatg agtcgtttcc gctcgaaggc    780

ggtgtcgcca tctccttcgg ccccaacctc caccggcggg tgtttcggcg cctcgtggac    840

tgcgccgaca ggcatcgcat cccgtatcag atcgagctgt cgcaggggcc ggtgggcgcg    900

gacgccaacg catttcaaat tgccggcccc ggcctcgcgg cggcgctcat cggtccgccg    960

attcggtaca tgcacacgtc ggtcgaaacc gtcgcttacg acgacatttg gcagtgcgcg   1020

cgactcctcg cccattactt ggcggaggtc gacgccgcgc aggtggagga gttgacatgt   1080

tactga                                                              1086


<210>  129
<211>  1086
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 118

<400>  129
gtgcggtatg aggaggtgtc tccagtgtcc aagtacgtga gcgtgttcaa gcagttgctc     60

gaagcgcacg gcgggccagg cttcgaggag gacgtgcgca acctcattct ccctcatcta    120

tcggaatacg cgacggagat gtggaccgac gcgctcggca acctcatcgg cctcgtcccg    180

ggtgtgggag aagggcggcg gccgcgggtg ctcgtgtccg cacacatcga cgaaattgca    240

ctggtcgtca cccgcatcga atcgggcgga tttctgcgtc tcgcgcaggc ggggggattc    300

gatccgcgga cgctcgtcgg ccaagaggtc gtggttcacg cccaaagcgg ccgggtctgg    360

ggcgtcatcg gggccaaacc gccgcacctc acgcctcctt ccgagcggtc gaaagccgcg    420

aaactcgaag atctgtacgt cgatctcgcc ctccctgagg aggaggtgcg cgcgcgcgtc    480

cgggtgggcg atcgcgtcac gcttcgccgc tcgcccgtcg atctgctcaa cggccggatc    540

gcgggcaaat cggtcgacaa ccgggcgagt gcagccgttc tgttggaggc gctcgccttg    600

ctgaagggca tggtgcacag cgcggatctc tacgccgtgt ttacggtgca ggaggaggtc    660

ggcctgcggg gggccagaac ggctggattt ggcctggcgc ccgacatcgc cattgccgtg    720

gacgtcacct tcggggcgtt tcccgggcag gcgccggatg agtcgtttcc gctcgaaggc    780

ggtgtcgcca tctccttcgg ccccaacctc caccggcggg tgtttcggcg cctcgtggac    840

tgcgccgaca ggcatcgcat cccgtatcag atcgagctgt cgcaggggcc ggtgggcgcg    900

gacgccaacg catttcaaat tgccggcccc ggcctcgcgg cggcgctcat cggtccgccg    960

attcggtaca tgcacacgtc ggtcgaaacc gtcgcttacg acgacatttg gcagtgcgcg   1020

cgactcctcg cccattactt ggcggaggtc gacgccgcgc aggtggagga gttgacatgt   1080

tactga                                                              1086


<210>  130
<211>  361
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:119 and encoded by SEQ ID NO:125

<400>  130

Met Lys Tyr Glu Glu Val Ser Pro Leu Ser Lys Tyr Val Ser Val Phe 
1               5                   10                  15      


Lys Gln Leu Leu Glu Ala His Gly Gly Pro Gly Phe Glu Glu Asp Val 
            20                  25                  30          


Arg Asn Leu Ile Leu Pro His Leu Ser Glu Tyr Ala Thr Glu Met Trp 
        35                  40                  45              


Thr Asp Ala Leu Gly Asn Leu Ile Gly Leu Val Pro Gly Val Gly Glu 
    50                  55                  60                  


Gly Arg Arg Pro Arg Val Leu Val Ser Ala His Ile Asp Glu Ile Ala 
65                  70                  75                  80  


Leu Val Val Thr Arg Ile Glu Ser Gly Gly Phe Leu Arg Leu Ala Gln 
                85                  90                  95      


Ala Gly Gly Phe Asp Pro Arg Thr Leu Val Gly Gln Glu Val Val Val 
            100                 105                 110         


His Ala Gln Ser Gly Arg Val Trp Gly Val Ile Gly Ala Lys Pro Pro 
        115                 120                 125             


His Leu Thr Pro Pro Ser Glu Arg Ser Lys Ala Ala Lys Leu Glu Asp 
    130                 135                 140                 


Leu Tyr Val Asp Leu Ala Leu Pro Glu Glu Glu Val Arg Ala Arg Val 
145                 150                 155                 160 


Arg Val Gly Asp Arg Val Thr Leu Arg Arg Ser Pro Val Asp Leu Leu 
                165                 170                 175     


Asn Gly Arg Ile Ala Gly Lys Ser Val Asp Asn Arg Ala Ser Ala Ala 
            180                 185                 190         


Val Leu Leu Glu Ala Leu Ala Leu Leu Lys Gly Met Val His Ser Ala 
        195                 200                 205             


Asp Leu Tyr Ala Val Phe Thr Val Gln Glu Glu Val Gly Leu Arg Gly 
    210                 215                 220                 


Ala Arg Thr Ala Gly Phe Gly Leu Ala Pro Asp Ile Ala Ile Ala Val 
225                 230                 235                 240 


Asp Val Thr Phe Gly Ala Phe Pro Gly Gln Ala Pro Asp Glu Ser Phe 
                245                 250                 255     


Pro Leu Glu Gly Gly Val Ala Ile Ser Phe Gly Pro Asn Leu His Arg 
            260                 265                 270         


Arg Val Phe Arg Arg Leu Val Asp Cys Ala Asp Arg His Arg Ile Pro 
        275                 280                 285             


Tyr Gln Ile Glu Leu Ser Gln Gly Pro Val Gly Ala Asp Ala Asn Ala 
    290                 295                 300                 


Phe Gln Ile Ala Gly Pro Gly Leu Ala Ala Ala Leu Ile Gly Pro Pro 
305                 310                 315                 320 


Ile Arg Tyr Met His Thr Ser Val Glu Thr Val Ala Tyr Asp Asp Ile 
                325                 330                 335     


Trp Gln Cys Ala Arg Leu Leu Ala His Tyr Leu Ala Glu Val Asp Ala 
            340                 345                 350         


Ala Gln Val Glu Glu Leu Thr Cys Tyr 
        355                 360     


<210>  131
<211>  361
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:119 and encoded by SEQ ID NO:126

<400>  131

Met Arg Tyr Glu Glu Ile Ser Pro Leu Ser Lys Tyr Val Ser Val Phe 
1               5                   10                  15      


Lys Gln Leu Leu Glu Ala His Gly Gly Pro Gly Phe Glu Glu Asp Val 
            20                  25                  30          


Arg Asn Leu Ile Leu Pro His Leu Ser Glu Tyr Ala Thr Glu Met Trp 
        35                  40                  45              


Thr Asp Ala Leu Gly Asn Leu Ile Gly Leu Val Pro Gly Val Gly Glu 
    50                  55                  60                  


Gly Arg Arg Pro Arg Val Leu Val Ser Ala His Ile Asp Glu Ile Ala 
65                  70                  75                  80  


Leu Val Val Thr Arg Ile Glu Ser Gly Gly Phe Leu Arg Leu Ala Gln 
                85                  90                  95      


Ala Gly Gly Phe Asp Pro Arg Thr Leu Val Gly Gln Glu Val Val Val 
            100                 105                 110         


His Ala Gln Ser Gly Arg Val Trp Gly Val Ile Gly Ala Lys Pro Pro 
        115                 120                 125             


His Leu Thr Pro Pro Ser Glu Arg Ser Lys Ala Ala Lys Leu Glu Asp 
    130                 135                 140                 


Leu Tyr Val Asp Leu Ala Leu Pro Glu Glu Glu Val Arg Ala Arg Val 
145                 150                 155                 160 


Arg Val Gly Asp Arg Val Thr Leu Arg Arg Ser Pro Val Asp Leu Leu 
                165                 170                 175     


Asn Gly Arg Ile Ala Gly Lys Ser Val Asp Asn Arg Ala Ser Ala Ala 
            180                 185                 190         


Val Leu Leu Glu Ala Leu Ala Leu Leu Lys Gly Met Val His Ser Ala 
        195                 200                 205             


Asp Leu Tyr Ala Val Phe Thr Val Gln Glu Glu Val Gly Leu Arg Gly 
    210                 215                 220                 


Ala Arg Thr Ala Gly Phe Gly Leu Ala Pro Asp Ile Ala Ile Ala Val 
225                 230                 235                 240 


Asp Val Thr Phe Gly Ala Phe Pro Gly Gln Ala Pro Asp Glu Ser Phe 
                245                 250                 255     


Pro Leu Glu Gly Gly Val Ala Ile Ser Phe Gly Pro Asn Leu His Arg 
            260                 265                 270         


Arg Val Phe Arg Arg Leu Val Asp Cys Ala Asp Arg His Arg Ile Pro 
        275                 280                 285             


Tyr Gln Ile Glu Leu Ser Gln Gly Pro Val Gly Ala Asp Ala Asn Ala 
    290                 295                 300                 


Phe Gln Ile Ala Gly Pro Gly Leu Ala Ala Ala Leu Ile Gly Pro Pro 
305                 310                 315                 320 


Ile Arg Tyr Met His Thr Ser Val Glu Thr Val Ala Tyr Asp Asp Ile 
                325                 330                 335     


Trp Gln Cys Ala Arg Leu Leu Ala His Tyr Leu Ala Glu Val Asp Ala 
            340                 345                 350         


Ala Gln Val Glu Glu Leu Thr Cys Tyr 
        355                 360     


<210>  132
<211>  361
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:119 and encoded by SEQ ID NO:127

<400>  132

Met Arg Tyr Glu Glu Leu Ser Pro Leu Ser Lys Tyr Val Ser Val Phe 
1               5                   10                  15      


Lys Gln Leu Leu Glu Ala His Gly Gly Pro Gly Phe Glu Glu Asp Val 
            20                  25                  30          


Arg Asn Leu Ile Leu Pro His Leu Ser Glu Tyr Ala Thr Glu Met Trp 
        35                  40                  45              


Thr Asp Ala Leu Gly Asn Leu Ile Gly Leu Val Pro Gly Val Gly Glu 
    50                  55                  60                  


Gly Arg Arg Pro Arg Val Leu Val Ser Ala His Ile Asp Glu Ile Ala 
65                  70                  75                  80  


Leu Val Val Thr Arg Ile Glu Ser Gly Gly Phe Leu Arg Leu Ala Gln 
                85                  90                  95      


Ala Gly Gly Phe Asp Pro Arg Thr Leu Val Gly Gln Glu Val Val Val 
            100                 105                 110         


His Ala Gln Ser Gly Arg Val Trp Gly Val Ile Gly Ala Lys Pro Pro 
        115                 120                 125             


His Leu Thr Pro Pro Ser Glu Arg Ser Lys Ala Ala Lys Leu Glu Asp 
    130                 135                 140                 


Leu Tyr Val Asp Leu Ala Leu Pro Glu Glu Glu Val Arg Ala Arg Val 
145                 150                 155                 160 


Arg Val Gly Asp Arg Val Thr Leu Arg Arg Ser Pro Val Asp Leu Leu 
                165                 170                 175     


Asn Gly Arg Ile Ala Gly Lys Ser Val Asp Asn Arg Ala Ser Ala Ala 
            180                 185                 190         


Val Leu Leu Glu Ala Leu Ala Leu Leu Lys Gly Met Val His Ser Ala 
        195                 200                 205             


Asp Leu Tyr Ala Val Phe Thr Val Gln Glu Glu Val Gly Leu Arg Gly 
    210                 215                 220                 


Ala Arg Thr Ala Gly Phe Gly Leu Ala Pro Asp Ile Ala Ile Ala Val 
225                 230                 235                 240 


Asp Val Thr Phe Gly Ala Phe Pro Gly Gln Ala Pro Asp Glu Ser Phe 
                245                 250                 255     


Pro Leu Glu Gly Gly Val Ala Ile Ser Phe Gly Pro Asn Leu His Arg 
            260                 265                 270         


Arg Val Phe Arg Arg Leu Val Asp Cys Ala Asp Arg His Arg Ile Pro 
        275                 280                 285             


Tyr Gln Ile Glu Leu Ser Gln Gly Pro Val Gly Ala Asp Ala Asn Ala 
    290                 295                 300                 


Phe Gln Ile Ala Gly Pro Gly Leu Ala Ala Ala Leu Ile Gly Pro Pro 
305                 310                 315                 320 


Ile Arg Tyr Met His Thr Ser Val Glu Thr Val Ala Tyr Asp Asp Ile 
                325                 330                 335     


Trp Gln Cys Ala Arg Leu Leu Ala His Tyr Leu Ala Glu Val Asp Ala 
            340                 345                 350         


Ala Gln Val Glu Glu Leu Thr Cys Tyr 
        355                 360     


<210>  133
<211>  361
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:119 and encoded by SEQ ID NO:128

<400>  133

Met Arg Tyr Glu Glu Val Ser Pro Ile Ser Lys Tyr Val Ser Val Phe 
1               5                   10                  15      


Lys Gln Leu Leu Glu Ala His Gly Gly Pro Gly Phe Glu Glu Asp Val 
            20                  25                  30          


Arg Asn Leu Ile Leu Pro His Leu Ser Glu Tyr Ala Thr Glu Met Trp 
        35                  40                  45              


Thr Asp Ala Leu Gly Asn Leu Ile Gly Leu Val Pro Gly Val Gly Glu 
    50                  55                  60                  


Gly Arg Arg Pro Arg Val Leu Val Ser Ala His Ile Asp Glu Ile Ala 
65                  70                  75                  80  


Leu Val Val Thr Arg Ile Glu Ser Gly Gly Phe Leu Arg Leu Ala Gln 
                85                  90                  95      


Ala Gly Gly Phe Asp Pro Arg Thr Leu Val Gly Gln Glu Val Val Val 
            100                 105                 110         


His Ala Gln Ser Gly Arg Val Trp Gly Val Ile Gly Ala Lys Pro Pro 
        115                 120                 125             


His Leu Thr Pro Pro Ser Glu Arg Ser Lys Ala Ala Lys Leu Glu Asp 
    130                 135                 140                 


Leu Tyr Val Asp Leu Ala Leu Pro Glu Glu Glu Val Arg Ala Arg Val 
145                 150                 155                 160 


Arg Val Gly Asp Arg Val Thr Leu Arg Arg Ser Pro Val Asp Leu Leu 
                165                 170                 175     


Asn Gly Arg Ile Ala Gly Lys Ser Val Asp Asn Arg Ala Ser Ala Ala 
            180                 185                 190         


Val Leu Leu Glu Ala Leu Ala Leu Leu Lys Gly Met Val His Ser Ala 
        195                 200                 205             


Asp Leu Tyr Ala Val Phe Thr Val Gln Glu Glu Val Gly Leu Arg Gly 
    210                 215                 220                 


Ala Arg Thr Ala Gly Phe Gly Leu Ala Pro Asp Ile Ala Ile Ala Val 
225                 230                 235                 240 


Asp Val Thr Phe Gly Ala Phe Pro Gly Gln Ala Pro Asp Glu Ser Phe 
                245                 250                 255     


Pro Leu Glu Gly Gly Val Ala Ile Ser Phe Gly Pro Asn Leu His Arg 
            260                 265                 270         


Arg Val Phe Arg Arg Leu Val Asp Cys Ala Asp Arg His Arg Ile Pro 
        275                 280                 285             


Tyr Gln Ile Glu Leu Ser Gln Gly Pro Val Gly Ala Asp Ala Asn Ala 
    290                 295                 300                 


Phe Gln Ile Ala Gly Pro Gly Leu Ala Ala Ala Leu Ile Gly Pro Pro 
305                 310                 315                 320 


Ile Arg Tyr Met His Thr Ser Val Glu Thr Val Ala Tyr Asp Asp Ile 
                325                 330                 335     


Trp Gln Cys Ala Arg Leu Leu Ala His Tyr Leu Ala Glu Val Asp Ala 
            340                 345                 350         


Ala Gln Val Glu Glu Leu Thr Cys Tyr 
        355                 360     


<210>  134
<211>  361
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:119 and encoded by SEQ ID NO:129

<400>  134

Met Arg Tyr Glu Glu Val Ser Pro Val Ser Lys Tyr Val Ser Val Phe 
1               5                   10                  15      


Lys Gln Leu Leu Glu Ala His Gly Gly Pro Gly Phe Glu Glu Asp Val 
            20                  25                  30          


Arg Asn Leu Ile Leu Pro His Leu Ser Glu Tyr Ala Thr Glu Met Trp 
        35                  40                  45              


Thr Asp Ala Leu Gly Asn Leu Ile Gly Leu Val Pro Gly Val Gly Glu 
    50                  55                  60                  


Gly Arg Arg Pro Arg Val Leu Val Ser Ala His Ile Asp Glu Ile Ala 
65                  70                  75                  80  


Leu Val Val Thr Arg Ile Glu Ser Gly Gly Phe Leu Arg Leu Ala Gln 
                85                  90                  95      


Ala Gly Gly Phe Asp Pro Arg Thr Leu Val Gly Gln Glu Val Val Val 
            100                 105                 110         


His Ala Gln Ser Gly Arg Val Trp Gly Val Ile Gly Ala Lys Pro Pro 
        115                 120                 125             


His Leu Thr Pro Pro Ser Glu Arg Ser Lys Ala Ala Lys Leu Glu Asp 
    130                 135                 140                 


Leu Tyr Val Asp Leu Ala Leu Pro Glu Glu Glu Val Arg Ala Arg Val 
145                 150                 155                 160 


Arg Val Gly Asp Arg Val Thr Leu Arg Arg Ser Pro Val Asp Leu Leu 
                165                 170                 175     


Asn Gly Arg Ile Ala Gly Lys Ser Val Asp Asn Arg Ala Ser Ala Ala 
            180                 185                 190         


Val Leu Leu Glu Ala Leu Ala Leu Leu Lys Gly Met Val His Ser Ala 
        195                 200                 205             


Asp Leu Tyr Ala Val Phe Thr Val Gln Glu Glu Val Gly Leu Arg Gly 
    210                 215                 220                 


Ala Arg Thr Ala Gly Phe Gly Leu Ala Pro Asp Ile Ala Ile Ala Val 
225                 230                 235                 240 


Asp Val Thr Phe Gly Ala Phe Pro Gly Gln Ala Pro Asp Glu Ser Phe 
                245                 250                 255     


Pro Leu Glu Gly Gly Val Ala Ile Ser Phe Gly Pro Asn Leu His Arg 
            260                 265                 270         


Arg Val Phe Arg Arg Leu Val Asp Cys Ala Asp Arg His Arg Ile Pro 
        275                 280                 285             


Tyr Gln Ile Glu Leu Ser Gln Gly Pro Val Gly Ala Asp Ala Asn Ala 
    290                 295                 300                 


Phe Gln Ile Ala Gly Pro Gly Leu Ala Ala Ala Leu Ile Gly Pro Pro 
305                 310                 315                 320 


Ile Arg Tyr Met His Thr Ser Val Glu Thr Val Ala Tyr Asp Asp Ile 
                325                 330                 335     


Trp Gln Cys Ala Arg Leu Leu Ala His Tyr Leu Ala Glu Val Asp Ala 
            340                 345                 350         


Ala Gln Val Glu Glu Leu Thr Cys Tyr 
        355                 360     


<210>  135
<211>  1110
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  135
ttggcagtgc gcgcgactcc tcgcccatta cttggcggag gtcgacgccg cgcaggtgga     60

ggagttgaca tgttactgaa ggagctgacg gaggccttcg gcccgacggg ctttgaggac    120

gaggtgcgcg gcatcgtccg ccgcgaactc gacgccatgg gtttatcggt gcgcacggac    180

gtcctgggga acgtgatcgc gtccacagga gaacatcatc ccggcccgcg ggtgatgctc    240

gatgcgcaca tggacgaggt gggtctcatg gtgacccata tcggggaagg gcgagaggag    300

ggcgggctgc tccggttccg accgctcggc ggcgtggatc cccgggtgct cgtgtccaag    360

ccggtgctca ttggggagcg gcgcattccg ggcgtcatcg gcgccaaacc ggttcacctg    420

cagcagccga gcgagcggga gaagcccatc ccgatggaga aactctacat cgacatcggc    480

gcccgcgacg cagacgacgc caggcgccac gtgaagccgg gcgacccggt ggtgttcgcc    540

accgcgtacc aagagcttcc gcatcggatg gcgaaggcga agtcgttcga cgatcgcgtc    600

ggctgctaca tcctgctcga ggcgctgcgc cggtggaagg gtgctctgcc ggtgtttggc    660

gcgtttaccg tgcaggagga aatcggtctg cgcggcgcac acgcggccgc gtaccagatt    720

gagcccgaca tcgccatcgc gctcgaaggc accgtggccc acgacgtcgt cggcacgccc    780

tcgcacggtc agtcgacggt ggtgggcaag ggcccggcca tcaccgtgca ggacggacag    840

accgtggcga atcggcgctt cgccgagttc ctctgggaaa cggcgaaggc gcgcaacatt    900

ccggtccagt ggcgcagggt caagggtgga accaacgatt tcggcgccat tcaccgcgtc    960

ggcaaagggg tgctgggcgg cgccatctcg gtgcctgtgc ggtacatcca cgctccgacg   1020

caggtggtgt cgctcgacga cgtgagtcat gccatcgatc tcgtggtcgc ggtgctcgac   1080

gagatcgcaa agggaggatt tcgcccatga                                    1110


<210>  136
<211>  369
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  136

Met Ala Val Arg Ala Thr Pro Arg Pro Leu Leu Gly Gly Gly Arg Arg 
1               5                   10                  15      


Arg Ala Gly Gly Gly Val Asp Met Leu Leu Lys Glu Leu Thr Glu Ala 
            20                  25                  30          


Phe Gly Pro Thr Gly Phe Glu Asp Glu Val Arg Gly Ile Val Arg Arg 
        35                  40                  45              


Glu Leu Asp Ala Met Gly Leu Ser Val Arg Thr Asp Val Leu Gly Asn 
    50                  55                  60                  


Val Ile Ala Ser Thr Gly Glu His His Pro Gly Pro Arg Val Met Leu 
65                  70                  75                  80  


Asp Ala His Met Asp Glu Val Gly Leu Met Val Thr His Ile Gly Glu 
                85                  90                  95      


Gly Arg Glu Glu Gly Gly Leu Leu Arg Phe Arg Pro Leu Gly Gly Val 
            100                 105                 110         


Asp Pro Arg Val Leu Val Ser Lys Pro Val Leu Ile Gly Glu Arg Arg 
        115                 120                 125             


Ile Pro Gly Val Ile Gly Ala Lys Pro Val His Leu Gln Gln Pro Ser 
    130                 135                 140                 


Glu Arg Glu Lys Pro Ile Pro Met Glu Lys Leu Tyr Ile Asp Ile Gly 
145                 150                 155                 160 


Ala Arg Asp Ala Asp Asp Ala Arg Arg His Val Lys Pro Gly Asp Pro 
                165                 170                 175     


Val Val Phe Ala Thr Ala Tyr Gln Glu Leu Pro His Arg Met Ala Lys 
            180                 185                 190         


Ala Lys Ser Phe Asp Asp Arg Val Gly Cys Tyr Ile Leu Leu Glu Ala 
        195                 200                 205             


Leu Arg Arg Trp Lys Gly Ala Leu Pro Val Phe Gly Ala Phe Thr Val 
    210                 215                 220                 


Gln Glu Glu Ile Gly Leu Arg Gly Ala His Ala Ala Ala Tyr Gln Ile 
225                 230                 235                 240 


Glu Pro Asp Ile Ala Ile Ala Leu Glu Gly Thr Val Ala His Asp Val 
                245                 250                 255     


Val Gly Thr Pro Ser His Gly Gln Ser Thr Val Val Gly Lys Gly Pro 
            260                 265                 270         


Ala Ile Thr Val Gln Asp Gly Gln Thr Val Ala Asn Arg Arg Phe Ala 
        275                 280                 285             


Glu Phe Leu Trp Glu Thr Ala Lys Ala Arg Asn Ile Pro Val Gln Trp 
    290                 295                 300                 


Arg Arg Val Lys Gly Gly Thr Asn Asp Phe Gly Ala Ile His Arg Val 
305                 310                 315                 320 


Gly Lys Gly Val Leu Gly Gly Ala Ile Ser Val Pro Val Arg Tyr Ile 
                325                 330                 335     


His Ala Pro Thr Gln Val Val Ser Leu Asp Asp Val Ser His Ala Ile 
            340                 345                 350         


Asp Leu Val Val Ala Val Leu Asp Glu Ile Ala Lys Gly Gly Phe Arg 
        355                 360                 365             


Pro 
    


<210>  137
<211>  349
<212>  PRT
<213>  Clostridium thermocellum

<400>  137

Met Leu Ile Lys Glu Leu Thr Glu Leu Asn Gly Val Ser Gly Asn Glu 
1               5                   10                  15      


Asp Glu Val Arg Lys Phe Ile Lys Glu Glu Ala Gln Lys Tyr Ala Asp 
            20                  25                  30          


Ser Ile Thr Glu Asp Ser Met Gly Asn Leu Ile Cys Tyr Lys Lys Gly 
        35                  40                  45              


Gly Ser Ser Lys Tyr Arg Val Met Leu Ser Ala His Met Asp Glu Val 
    50                  55                  60                  


Gly Phe Met Val Thr Gly Tyr Asp Asp Gly Leu Ile Lys Phe Ala Ser 
65                  70                  75                  80  


Ile Gly Gly Ile Asp Glu Arg Ile Leu Pro Gly Lys Arg Val Leu Val 
                85                  90                  95      


Gly Glu Lys Arg Ile Pro Gly Val Ile Gly Ser Lys Pro Ile His Leu 
            100                 105                 110         


Gln Glu Lys Ala Glu Arg Gly Asn Asn Ile Lys Leu Lys Asn Met Tyr 
        115                 120                 125             


Ile Asp Ile Gly Ala Glu Lys Lys Glu Glu Ala Glu Lys Leu Ala Pro 
    130                 135                 140                 


Leu Gly Glu Tyr Ile Ala Phe Tyr Ser Met Tyr Thr Glu Phe Gly Asp 
145                 150                 155                 160 


Gly Cys Ile Lys Ala Lys Ala Leu Asp Asp Arg Val Gly Cys Ala Ile 
                165                 170                 175     


Leu Leu Glu Ile Leu Lys Glu Arg Tyr Gly Phe Asp Leu Tyr Val Cys 
            180                 185                 190         


Phe Thr Val Gln Glu Glu Ile Gly Leu Arg Gly Ala Gly Val Ala Ala 
        195                 200                 205             


Phe Arg Val Asn Pro Asp Ile Ala Ile Val Val Glu Gly Thr Thr Cys 
    210                 215                 220                 


Ser Asp Val Pro Gly Ala Arg Glu His Glu Tyr Ser Thr Val Met Gly 
225                 230                 235                 240 


Asn Gly Ala Ala Leu Thr Ile Met Asp Arg Thr Ser Tyr Ser Asn Lys 
                245                 250                 255     


Lys Leu Val Asp Phe Met Tyr Lys Thr Ala Lys Asp Lys Asn Ile Pro 
            260                 265                 270         


Val Gln Tyr Lys Gln Thr Ala Thr Gly Gly Asn Asp Ala Gly Lys Ile 
        275                 280                 285             


Gln Leu Thr Arg Glu Gly Val Val Val Ala Ser Val Ser Val Pro Cys 
    290                 295                 300                 


Arg Tyr Ile His Ser Pro Val Ser Val Met Asn Arg Arg Asp Tyr Glu 
305                 310                 315                 320 


Ser Cys Leu Asn Leu Val Lys Ala Val Leu Glu Glu Phe Asp Asn Asn 
                325                 330                 335     


Glu Ser Leu Ile Glu Ser Phe Lys Leu His Asn Val Lys 
            340                 345                 


<210>  138
<211>  339
<212>  PRT
<213>  Thermoanaerobacter tengcongensis

<400>  138

Met Leu Leu Lys Glu Leu Thr Glu Leu Leu Gly Ala Ser Gly Asp Glu 
1               5                   10                  15      


Lys Glu Val Arg Glu Lys Ile Lys Glu Ile Val Lys Pro Tyr Val Asp 
            20                  25                  30          


Glu Leu Tyr Val Asp Arg Ile Gly Asn Leu Ile Ala Cys Lys Lys Gly 
        35                  40                  45              


Lys Lys Glu Lys Pro Lys Val Met Leu Ala Ala His Met Asp Glu Val 
    50                  55                  60                  


Ala Leu Met Val Lys Ser Val Asn Glu Asp Gly Thr Leu Ser Phe Ser 
65                  70                  75                  80  


Pro Val Gly Gly Val Asp Asn Arg Ile Leu Val Ala Lys Ala Val Lys 
                85                  90                  95      


Val Gly Glu Lys Lys Ile Asn Gly Val Ile Gly Ala Lys Pro Ile His 
            100                 105                 110         


Leu Gln Lys Lys Gly Glu Gln Glu Lys Pro Leu Asp Phe Asp Glu Leu 
        115                 120                 125             


Tyr Ile Asp Ile Gly Ala Ala Ser Lys Glu Glu Ala Leu Lys His Ile 
    130                 135                 140                 


Ser Pro Gly Asp Tyr Val Tyr Phe Glu Ser Asn Phe Glu Ile Leu Gly 
145                 150                 155                 160 


Asp Gly Tyr Val Lys Ala Lys Ala Leu Asp Asp Arg Ile Gly Cys Asn 
                165                 170                 175     


Val Leu Ile Glu Ile Leu Lys Asn Thr Tyr Glu Tyr Pro Val Cys Ala 
            180                 185                 190         


Ala Phe Thr Val Gln Glu Glu Val Gly Leu Arg Gly Ala Gly Val Ala 
        195                 200                 205             


Ala Tyr Asn Val Glu Pro Asp Phe Ala Leu Val Val Glu Gly Thr Val 
    210                 215                 220                 


Ala Ala Asp Val Val Asp Ser Glu Pro His Leu Val Ser Thr Glu Leu 
225                 230                 235                 240 


Gly Lys Gly Pro Ala Ile Ser Leu Met Asp Arg Thr Thr Leu Tyr Asp 
                245                 250                 255     


Arg Lys Ile Ile Asp Lys Ile Val Arg Ile Ala Glu Glu Asn Asn Val 
            260                 265                 270         


Pro Tyr Gln Phe Arg Arg Ile Ala Ser Gly Gly Asn Asp Ala Gly Lys 
        275                 280                 285             


Ile His Leu Thr Lys Gly Gly Ile Lys Thr Val Ala Ile Ser Val Pro 
    290                 295                 300                 


Cys Arg Tyr Ile His Ser Phe Asn Ser Val Ala Lys Leu Ser Asp Phe 
305                 310                 315                 320 


Glu Asn Thr Val Lys Leu Val Asp Leu Val Ile Lys Asn Ile Glu Glu 
                325                 330                 335     


Val Leu Lys 
            


<210>  139
<211>  339
<212>  PRT
<213>  Thermoanaerobacter ethanolicus

<400>  139

Met Leu Leu Lys Glu Leu Thr Glu Leu Leu Gly Ala Ser Gly Asp Glu 
1               5                   10                  15      


Lys Glu Val Arg Glu Lys Ile Lys Glu Ile Val Lys Pro Tyr Val Asp 
            20                  25                  30          


Glu Leu Tyr Val Asp Arg Ile Gly Asn Leu Ile Ala Cys Lys Lys Gly 
        35                  40                  45              


Lys Lys Glu Lys Pro Lys Val Met Leu Ala Ala His Met Asp Glu Val 
    50                  55                  60                  


Ala Leu Met Val Lys Ser Val Asn Glu Asp Gly Thr Leu Ser Phe Ser 
65                  70                  75                  80  


Pro Val Gly Gly Val Asp Asn Arg Ile Leu Val Ala Lys Ala Val Lys 
                85                  90                  95      


Val Gly Glu Lys Lys Ile Asn Gly Val Ile Gly Ala Lys Pro Ile His 
            100                 105                 110         


Leu Gln Lys Lys Gly Glu Gln Glu Lys Pro Leu Asp Phe Asp Glu Leu 
        115                 120                 125             


Tyr Ile Asp Ile Gly Ala Ala Ser Lys Glu Glu Ala Leu Lys His Val 
    130                 135                 140                 


Ser Pro Gly Asp Tyr Val Tyr Phe Glu Ser Asn Phe Glu Leu Leu Gly 
145                 150                 155                 160 


Asp Gly Tyr Val Lys Ala Lys Ala Leu Asp Asp Arg Ile Gly Cys Asn 
                165                 170                 175     


Val Leu Ile Glu Ile Leu Lys Asn Thr Tyr Glu Tyr Pro Val Cys Ala 
            180                 185                 190         


Ala Phe Thr Val Gln Glu Glu Val Gly Leu Arg Gly Ala Gly Val Ala 
        195                 200                 205             


Ala Tyr Asn Val Asp Pro Asp Phe Ala Ile Val Val Glu Gly Thr Val 
    210                 215                 220                 


Ala Ala Asp Val Val Asp Ser Glu Pro His Leu Val Ser Thr Glu Leu 
225                 230                 235                 240 


Gly Lys Gly Pro Ala Ile Ser Leu Met Asp Arg Thr Thr Leu Tyr Asp 
                245                 250                 255     


Arg Lys Ile Ile Asp Lys Ile Val Lys Ile Ala Glu Lys Asn Lys Ile 
            260                 265                 270         


Pro Tyr Gln Phe Arg Arg Ile Ala Ser Gly Gly Asn Asp Ala Gly Lys 
        275                 280                 285             


Ile His Leu Thr Lys Gly Gly Ile Lys Thr Val Ala Ile Ser Val Pro 
    290                 295                 300                 


Cys Arg Tyr Ile His Ser Phe Asn Ser Val Ala Lys Leu Ser Asp Phe 
305                 310                 315                 320 


Glu Asn Thr Val Lys Leu Val Asp Leu Val Ile Lys Asn Ile Glu Glu 
                325                 330                 335     


Val Leu Lys 
            


<210>  140
<211>  340
<212>  PRT
<213>  Thermoanaerobacter ethanolicus

<400>  140

Met Leu Leu Lys Glu Leu Thr Glu Ile Met Gly Ala Ser Gly Asp Glu 
1               5                   10                  15      


Lys Glu Ile Arg Glu Lys Ile Lys Ser Ile Val Glu Pro Tyr Val Asp 
            20                  25                  30          


Asn Val Tyr Val Asp Lys Ile Gly Asn Leu Ile Ala Cys Lys Lys Gly 
        35                  40                  45              


Lys Lys Asp Lys Pro Lys Ile Met Leu Ala Ala His Met Asp Glu Val 
    50                  55                  60                  


Gly Leu Met Val Lys Ser Val Asn Glu Asp Gly Thr Leu Ser Phe Phe 
65                  70                  75                  80  


Pro Val Gly Gly Val Asp Asn Arg Ile Leu Val Ala Lys Thr Val Lys 
                85                  90                  95      


Val Gly Glu Lys Gly Ile Asn Gly Val Ile Gly Ala Lys Pro Ile His 
            100                 105                 110         


Leu Gln Lys Arg Asp Glu Gln Gln Lys Pro Leu Asp Phe Asp Ser Leu 
        115                 120                 125             


Tyr Ile Asp Ile Gly Ala Thr Ser Lys Glu Glu Ala Leu Lys His Val 
    130                 135                 140                 


Ser Pro Gly Asp Tyr Val Tyr Phe Asp Ser Asn Phe Glu Ile Leu Gly 
145                 150                 155                 160 


Asn Gly Tyr Val Lys Ala Lys Ala Leu Asp Asp Arg Ile Gly Cys Asn 
                165                 170                 175     


Val Leu Ile Glu Asn Leu Lys Asn Glu Tyr Glu Tyr Thr Val Cys Ala 
            180                 185                 190         


Ala Phe Thr Val Glu Glu Glu Val Gly Leu Arg Gly Ala Gly Val Ala 
        195                 200                 205             


Ala Tyr Asn Val Glu Pro Asp Phe Ala Ile Ile Val Glu Gly Thr Val 
    210                 215                 220                 


Ala Ala Asp Val Thr Asp Ser Val Pro His Leu Val Ser Thr Glu Leu 
225                 230                 235                 240 


Gly Lys Gly Pro Ala Ile Ser Leu Met Asp Arg Thr Thr Leu Tyr Asp 
                245                 250                 255     


Lys Lys Leu Ile Asp Lys Ile Ala Lys Ile Ala Asp Glu Asn Lys Val 
            260                 265                 270         


Pro Tyr Gln Phe Arg Arg Ile Ala Ser Gly Gly Asn Asp Ala Gly Lys 
        275                 280                 285             


Ile His Leu Thr Lys Gly Gly Ile Lys Thr Ile Ala Val Ser Val Pro 
    290                 295                 300                 


Cys Arg Tyr Ile His Ser Phe Asn Ser Val Ala Phe Leu Glu Asp Phe 
305                 310                 315                 320 


Asn Asn Thr Val Lys Leu Val Asp Leu Ile Ile Lys Asn Ile Glu Lys 
                325                 330                 335     


Glu Ala Leu Ile 
            340 


<210>  141
<211>  336
<212>  PRT
<213>  Clostridium acetobutylicum 

<400>  141

Met Leu Leu Asp Lys Leu Cys Asn Ala Ala Gly Pro Ser Ser Phe Glu 
1               5                   10                  15      


Gly Asp Val Arg Ala Ile Ile Lys Lys Glu Ile Lys Ala Phe Val Asp 
            20                  25                  30          


Glu Ile Lys Val Asp Arg Met Gly Asn Ile Ile Ala His Lys Lys Gly 
        35                  40                  45              


Ser Gly Lys Lys Ile Met Leu Asp Ala His Met Asp Glu Val Gly Phe 
    50                  55                  60                  


Ile Ile Thr Ser Ile Asn Glu Asp Gly Thr Ile Lys Phe Ala Ser Ile 
65                  70                  75                  80  


Gly Gly Ile Asn Gly Lys Ile Ile Pro Ser Lys Val Val Tyr Ile Gly 
                85                  90                  95      


Glu Asn Lys Ile Pro Gly Val Ile Gly Ile Lys Pro Ile His Leu Gln 
            100                 105                 110         


Ser Ala Glu Glu Arg Lys Gly Ser Ala Ser Tyr Asp Asn Cys Phe Ile 
        115                 120                 125             


Asp Ile Gly Ser Lys Ser Lys Glu Glu Thr Lys Lys Tyr Val Ser Leu 
    130                 135                 140                 


Gly Asp Tyr Ala Val Phe Ser Thr Glu Tyr Gly Glu Phe Gly Glu Gly 
145                 150                 155                 160 


Phe Ile Lys Ala Lys Ala Leu Asp Asp Arg Val Gly Cys Ala Val Leu 
                165                 170                 175     


Ile Glu Leu Leu Lys Glu Asn Tyr Glu Cys Asp Leu Tyr Ala Val Phe 
            180                 185                 190         


Asn Val Gln Glu Glu Val Gly Glu Arg Gly Ala Tyr Val Ser Ala Phe 
        195                 200                 205             


Gln Val Arg Pro Asp Ile Gly Ile Ala Leu Glu Gly Thr Val Cys Ala 
    210                 215                 220                 


Asp Met Pro Asn Val Pro Glu Tyr Leu Arg Ala Thr Glu Leu Gly Lys 
225                 230                 235                 240 


Gly Pro Ala Ile Ser Ile Met Asp Lys Ser Ser Ile Tyr Asn Glu Glu 
                245                 250                 255     


Ile Thr Leu Glu Leu Ile Lys Ile Ala Lys Glu Asn Asn Leu Ala His 
            260                 265                 270         


Gln Met Arg Lys Ser Thr Ser Gly Gly Asn Asp Ala Gly Ala Ile Ala 
        275                 280                 285             


Ser Thr Gly Glu Gly Ala Lys Val Ala Ala Val Ser Val Pro Cys Arg 
    290                 295                 300                 


Tyr Ile His Ser Ser Val Ser Val Ala Ser Leu Lys Asp Ile Glu Asn 
305                 310                 315                 320 


Thr Ile Glu Leu Leu Lys Lys Tyr Leu Leu Ser Phe Lys Gly Gly Lys 
                325                 330                 335     


<210>  142
<211>  1110
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 135

<400>  142
ttggcagtgc gcgcgactcc tcgcccatta cttggcggag gtcgacgccg cgcaggtgga     60

ggagttgaca tgttactgaa ggagctgacg gaggccttcg gcccgacggg ctttgaggac    120

gaggtgcgcg gcatcctccg ccgcgaactc gacgccatgg gtttatcggt gcgcacggac    180

gtcctgggga acgtgatcgc gtccacagga gaacatcatc ccggcccgcg ggtgatgctc    240

gatgcgcaca tggacgaggt gggtctcatg gtgacccata tcggggaagg gcgagaggag    300

ggcgggctgc tccggttccg accgctcggc ggcgtggatc cccgggtgct cgtgtccaag    360

ccggtgctca ttggggagcg gcgcattccg ggcgtcatcg gcgccaaacc ggttcacctg    420

cagcagccga gcgagcggga gaagcccatc ccgatggaga aactctacat cgacatcggc    480

gcccgcgacg cagacgacgc caggcgccac gtgaagccgg gcgacccggt ggtgttcgcc    540

accgcgtacc aagagcttcc gcatcggatg gcgaaggcga agtcgttcga cgatcgcgtc    600

ggctgctaca tcctgctcga ggcgctgcgc cggtggaagg gtgctctgcc ggtgtttggc    660

gcgtttaccg tgcaggagga aatcggtctg cgcggcgcac acgcggccgc gtaccagatt    720

gagcccgaca tcgccatcgc gctcgaaggc accgtggccc acgacgtcgt cggcacgccc    780

tcgcacggtc agtcgacggt ggtgggcaag ggcccggcca tcaccgtgca ggacggacag    840

accgtggcga atcggcgctt cgccgagttc ctctgggaaa cggcgaaggc gcgcaacatt    900

ccggtccagt ggcgcagggt caagggtgga accaacgatt tcggcgccat tcaccgcgtc    960

ggcaaagggg tgctgggcgg cgccatctcg gtgcctgtgc ggtacatcca cgctccgacg   1020

caggtggtgt cgctcgacga cgtgagtcat gccatcgatc tcgtggtcgc ggtgctcgac   1080

gagatcgcaa agggaggatt tcgcccatga                                    1110


<210>  143
<211>  1110
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 135

<400>  143
ttggcagtgc gcgcgactcc tcgcccatta cttggcggag gtcgacgccg cgcaggtgga     60

ggagttgaca tgttactgaa ggagctgacg gaggccttcg gcccgacggg ctttgaggac    120

gaggtgcgcg gcatcgtcaa gcgcgaactc gacgccatgg gtttatcggt gcgcacggac    180

gtcctgggga acgtgatcgc gtccacagga gaacatcatc ccggcccgcg ggtgatgctc    240

gatgcgcaca tggacgaggt gggtctcatg gtgacccata tcggggaagg gcgagaggag    300

ggcgggctgc tccggttccg accgctcggc ggcgtggatc cccgggtgct cgtgtccaag    360

ccggtgctca ttggggagcg gcgcattccg ggcgtcatcg gcgccaaacc ggttcacctg    420

cagcagccga gcgagcggga gaagcccatc ccgatggaga aactctacat cgacatcggc    480

gcccgcgacg cagacgacgc caggcgccac gtgaagccgg gcgacccggt ggtgttcgcc    540

accgcgtacc aagagcttcc gcatcggatg gcgaaggcga agtcgttcga cgatcgcgtc    600

ggctgctaca tcctgctcga ggcgctgcgc cggtggaagg gtgctctgcc ggtgtttggc    660

gcgtttaccg tgcaggagga aatcggtctg cgcggcgcac acgcggccgc gtaccagatt    720

gagcccgaca tcgccatcgc gctcgaaggc accgtggccc acgacgtcgt cggcacgccc    780

tcgcacggtc agtcgacggt ggtgggcaag ggcccggcca tcaccgtgca ggacggacag    840

accgtggcga atcggcgctt cgccgagttc ctctgggaaa cggcgaaggc gcgcaacatt    900

ccggtccagt ggcgcagggt caagggtgga accaacgatt tcggcgccat tcaccgcgtc    960

ggcaaagggg tgctgggcgg cgccatctcg gtgcctgtgc ggtacatcca cgctccgacg   1020

caggtggtgt cgctcgacga cgtgagtcat gccatcgatc tcgtggtcgc ggtgctcgac   1080

gagatcgcaa agggaggatt tcgcccatga                                    1110


<210>  144
<211>  1110
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 135

<400>  144
ttggcagtgc gcgcgactcc tcgcccatta cttggcggag gtcgacgccg cgcaggtgga     60

ggagttgaca tgttactgaa ggagctgacg gaggccttcg gcccgacggg ctttgaggac    120

gaggtgcgcg gcatcgtccg ccgcgaactc gacgccatgg gtttatcgct gcgcacggac    180

gtcctgggga acgtgatcgc gtccacagga gaacatcatc ccggcccgcg ggtgatgctc    240

gatgcgcaca tggacgaggt gggtctcatg gtgacccata tcggggaagg gcgagaggag    300

ggcgggctgc tccggttccg accgctcggc ggcgtggatc cccgggtgct cgtgtccaag    360

ccggtgctca ttggggagcg gcgcattccg ggcgtcatcg gcgccaaacc ggttcacctg    420

cagcagccga gcgagcggga gaagcccatc ccgatggaga aactctacat cgacatcggc    480

gcccgcgacg cagacgacgc caggcgccac gtgaagccgg gcgacccggt ggtgttcgcc    540

accgcgtacc aagagcttcc gcatcggatg gcgaaggcga agtcgttcga cgatcgcgtc    600

ggctgctaca tcctgctcga ggcgctgcgc cggtggaagg gtgctctgcc ggtgtttggc    660

gcgtttaccg tgcaggagga aatcggtctg cgcggcgcac acgcggccgc gtaccagatt    720

gagcccgaca tcgccatcgc gctcgaaggc accgtggccc acgacgtcgt cggcacgccc    780

tcgcacggtc agtcgacggt ggtgggcaag ggcccggcca tcaccgtgca ggacggacag    840

accgtggcga atcggcgctt cgccgagttc ctctgggaaa cggcgaaggc gcgcaacatt    900

ccggtccagt ggcgcagggt caagggtgga accaacgatt tcggcgccat tcaccgcgtc    960

ggcaaagggg tgctgggcgg cgccatctcg gtgcctgtgc ggtacatcca cgctccgacg   1020

caggtggtgt cgctcgacga cgtgagtcat gccatcgatc tcgtggtcgc ggtgctcgac   1080

gagatcgcaa agggaggatt tcgcccatga                                    1110


<210>  145
<211>  1110
<212>  DNA
<213>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 135

<400>  145
ttggcagtgc gcgcgactcc tcgcccatta cttggcggag gtcgacgccg cgcaggtgga     60

ggagttgaca tgttactgaa ggagctgacg gaggccttcg gcccgacggg ctttgaggac    120

gaggtgcgcg gcatcctccg ccgcgaactc gacgccatgg gtttatcggt gcgcacggac    180

gtcctgggga acgtgatcgc gtccacagga gaacatcatc ccggcccgcg ggtgatgctc    240

gatgcgcaca tggacgaggt gggtctcatg gtgacccata tcggggaagg gcgagaggag    300

ggcgggctgc tccggttccg accgctcggc ggcgtggatc cccgggtgct cgtgtccaag    360

ccggtgctca ttggggagcg gcgcattccg ggcgtcatcg gcgccaaacc ggttcacctg    420

cagcagccga gcgagcggga gaagcccatc ccgatggaga aactctacat cgacatcggc    480

gcccgcgacg cagacgacgc caggcgccac gtgaagccgg gcgacccggt ggtgttcgcc    540

accgcgtacc aagagcttcc gcatcggatg gcgaaggcga agtcgttcga cgatcgcgtc    600

ggctgctaca tcctgctcga ggcgctgcgc cggtggaagg gtgctctgcc ggtgtttggc    660

gcgtttaccg tgcaggagga aatcggtctg cgcggcgcac acgcggccgc gtaccagatt    720

gagcccgaca tcgccatcgc gctcgaaggc accgtggccc acgacgtcgt cggcacgccc    780

tcgcacggtc agtcgacggt ggtgggcaag ggcccggcca tcaccgtgca ggacggacag    840

accgtggcga atcggcgctt cgccgagttc ctctgggaaa cggcgaaggc gcgcaacatt    900

ccggtccagt ggcgcagggt caagggtgga accaacgatt tcggcgccat tcaccgcgtc    960

ggcaaagggg tgctgggcgg cgccatctcg gtgcctgtgc ggtacatcca cgctccgacg   1020

caggtggtgt cgctcgacga cgtgagtcat gccatcgatc tcgtggtcgc ggtgctcgac   1080

gagatcgcaa agggaggatt tcgcccatga                                    1110


<210>  146
<211>  1110
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 135

<400>  146
ttggcagtgc gcgcgactcc tcgcccatta cttggcggag gtcgacgccg cgcaggtgga     60

ggagttgaca tgttactgaa ggagctgacg gaggccttcg gcccgacggg ctttgaggac    120

gaggtgcgcg gcatcgtccg ccgcgaactc gacgccatgg gtttatcggt gcgcacggac    180

gtcctgggga acgtgatcgc gtccacagga gaacatcatc ccggcccgcg ggtgatgctc    240

gatgcgcaca tggacgaggt gggtctcatg gtgacccata tcggggaagg gcgagaggag    300

ggcggggtac tccggttccg accgctcggc ggcgtggatc cccgggtgct cgtgtccaag    360

ccggtgctca ttggggagcg gcgcattccg ggcgtcatcg gcgccaaacc ggttcacctg    420

cagcagccga gcgagcggga gaagcccatc ccgatggaga aactctacat cgacatcggc    480

gcccgcgacg cagacgacgc caggcgccac gtgaagccgg gcgacccggt ggtgttcgcc    540

accgcgtacc aagagcttcc gcatcggatg gcgaaggcga agtcgttcga cgatcgcgtc    600

ggctgctaca tcctgctcga ggcgctgcgc cggtggaagg gtgctctgcc ggtgtttggc    660

gcgtttaccg tgcaggagga aatcggtctg cgcggcgcac acgcggccgc gtaccagatt    720

gagcccgaca tcgccatcgc gctcgaaggc accgtggccc acgacgtcgt cggcacgccc    780

tcgcacggtc agtcgacggt ggtgggcaag ggcccggcca tcaccgtgca ggacggacag    840

accgtggcga atcggcgctt cgccgagttc ctctgggaaa cggcgaaggc gcgcaacatt    900

ccggtccagt ggcgcagggt caagggtgga accaacgatt tcggcgccat tcaccgcgtc    960

ggcaaagggg tgctgggcgg cgccatctcg gtgcctgtgc ggtacatcca cgctccgacg   1020

caggtggtgt cgctcgacga cgtgagtcat gccatcgatc tcgtggtcgc ggtgctcgac   1080

gagatcgcaa agggaggatt tcgcccatga                                    1110


<210>  147
<211>  369
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:136 and encoded by SEQ ID NO:142

<400>  147

Met Ala Val Arg Ala Thr Pro Arg Pro Leu Leu Gly Gly Gly Arg Arg 
1               5                   10                  15      


Arg Ala Gly Gly Gly Val Asp Met Leu Leu Lys Glu Leu Thr Glu Ala 
            20                  25                  30          


Phe Gly Pro Thr Gly Phe Glu Asp Glu Val Arg Gly Leu Val Arg Arg 
        35                  40                  45              


Glu Leu Asp Ala Met Gly Leu Ser Val Arg Thr Asp Val Leu Gly Asn 
    50                  55                  60                  


Val Ile Ala Ser Thr Gly Glu His His Pro Gly Pro Arg Val Met Leu 
65                  70                  75                  80  


Asp Ala His Met Asp Glu Val Gly Leu Met Val Thr His Ile Gly Glu 
                85                  90                  95      


Gly Arg Glu Glu Gly Gly Leu Leu Arg Phe Arg Pro Leu Gly Gly Val 
            100                 105                 110         


Asp Pro Arg Val Leu Val Ser Lys Pro Val Leu Ile Gly Glu Arg Arg 
        115                 120                 125             


Ile Pro Gly Val Ile Gly Ala Lys Pro Val His Leu Gln Gln Pro Ser 
    130                 135                 140                 


Glu Arg Glu Lys Pro Ile Pro Met Glu Lys Leu Tyr Ile Asp Ile Gly 
145                 150                 155                 160 


Ala Arg Asp Ala Asp Asp Ala Arg Arg His Val Lys Pro Gly Asp Pro 
                165                 170                 175     


Val Val Phe Ala Thr Ala Tyr Gln Glu Leu Pro His Arg Met Ala Lys 
            180                 185                 190         


Ala Lys Ser Phe Asp Asp Arg Val Gly Cys Tyr Ile Leu Leu Glu Ala 
        195                 200                 205             


Leu Arg Arg Trp Lys Gly Ala Leu Pro Val Phe Gly Ala Phe Thr Val 
    210                 215                 220                 


Gln Glu Glu Ile Gly Leu Arg Gly Ala His Ala Ala Ala Tyr Gln Ile 
225                 230                 235                 240 


Glu Pro Asp Ile Ala Ile Ala Leu Glu Gly Thr Val Ala His Asp Val 
                245                 250                 255     


Val Gly Thr Pro Ser His Gly Gln Ser Thr Val Val Gly Lys Gly Pro 
            260                 265                 270         


Ala Ile Thr Val Gln Asp Gly Gln Thr Val Ala Asn Arg Arg Phe Ala 
        275                 280                 285             


Glu Phe Leu Trp Glu Thr Ala Lys Ala Arg Asn Ile Pro Val Gln Trp 
    290                 295                 300                 


Arg Arg Val Lys Gly Gly Thr Asn Asp Phe Gly Ala Ile His Arg Val 
305                 310                 315                 320 


Gly Lys Gly Val Leu Gly Gly Ala Ile Ser Val Pro Val Arg Tyr Ile 
                325                 330                 335     


His Ala Pro Thr Gln Val Val Ser Leu Asp Asp Val Ser His Ala Ile 
            340                 345                 350         


Asp Leu Val Val Ala Val Leu Asp Glu Ile Ala Lys Gly Gly Phe Arg 
        355                 360                 365             


Pro 
    


<210>  148
<211>  369
<212>  PRT
<213>  artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:136 and encoded by SEQ ID NO:143

<400>  148

Met Ala Val Arg Ala Thr Pro Arg Pro Leu Leu Gly Gly Gly Arg Arg 
1               5                   10                  15      


Arg Ala Gly Gly Gly Val Asp Met Leu Leu Lys Glu Leu Thr Glu Ala 
            20                  25                  30          


Phe Gly Pro Thr Gly Phe Glu Asp Glu Val Arg Gly Ile Val Lys Arg 
        35                  40                  45              


Glu Leu Asp Ala Met Gly Leu Ser Val Arg Thr Asp Val Leu Gly Asn 
    50                  55                  60                  


Val Ile Ala Ser Thr Gly Glu His His Pro Gly Pro Arg Val Met Leu 
65                  70                  75                  80  


Asp Ala His Met Asp Glu Val Gly Leu Met Val Thr His Ile Gly Glu 
                85                  90                  95      


Gly Arg Glu Glu Gly Gly Leu Leu Arg Phe Arg Pro Leu Gly Gly Val 
            100                 105                 110         


Asp Pro Arg Val Leu Val Ser Lys Pro Val Leu Ile Gly Glu Arg Arg 
        115                 120                 125             


Ile Pro Gly Val Ile Gly Ala Lys Pro Val His Leu Gln Gln Pro Ser 
    130                 135                 140                 


Glu Arg Glu Lys Pro Ile Pro Met Glu Lys Leu Tyr Ile Asp Ile Gly 
145                 150                 155                 160 


Ala Arg Asp Ala Asp Asp Ala Arg Arg His Val Lys Pro Gly Asp Pro 
                165                 170                 175     


Val Val Phe Ala Thr Ala Tyr Gln Glu Leu Pro His Arg Met Ala Lys 
            180                 185                 190         


Ala Lys Ser Phe Asp Asp Arg Val Gly Cys Tyr Ile Leu Leu Glu Ala 
        195                 200                 205             


Leu Arg Arg Trp Lys Gly Ala Leu Pro Val Phe Gly Ala Phe Thr Val 
    210                 215                 220                 


Gln Glu Glu Ile Gly Leu Arg Gly Ala His Ala Ala Ala Tyr Gln Ile 
225                 230                 235                 240 


Glu Pro Asp Ile Ala Ile Ala Leu Glu Gly Thr Val Ala His Asp Val 
                245                 250                 255     


Val Gly Thr Pro Ser His Gly Gln Ser Thr Val Val Gly Lys Gly Pro 
            260                 265                 270         


Ala Ile Thr Val Gln Asp Gly Gln Thr Val Ala Asn Arg Arg Phe Ala 
        275                 280                 285             


Glu Phe Leu Trp Glu Thr Ala Lys Ala Arg Asn Ile Pro Val Gln Trp 
    290                 295                 300                 


Arg Arg Val Lys Gly Gly Thr Asn Asp Phe Gly Ala Ile His Arg Val 
305                 310                 315                 320 


Gly Lys Gly Val Leu Gly Gly Ala Ile Ser Val Pro Val Arg Tyr Ile 
                325                 330                 335     


His Ala Pro Thr Gln Val Val Ser Leu Asp Asp Val Ser His Ala Ile 
            340                 345                 350         


Asp Leu Val Val Ala Val Leu Asp Glu Ile Ala Lys Gly Gly Phe Arg 
        355                 360                 365             


Pro 
    


<210>  149
<211>  369
<212>  PRT
<213>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:136 and encoded by SEQ ID NO:144

<400>  149

Met Ala Val Arg Ala Thr Pro Arg Pro Leu Leu Gly Gly Gly Arg Arg 
1               5                   10                  15      


Arg Ala Gly Gly Gly Val Asp Met Leu Leu Lys Glu Leu Thr Glu Ala 
            20                  25                  30          


Phe Gly Pro Thr Gly Phe Glu Asp Glu Val Arg Gly Ile Val Arg Arg 
        35                  40                  45              


Glu Leu Asp Ala Met Gly Leu Ser Leu Arg Thr Asp Val Leu Gly Asn 
    50                  55                  60                  


Val Ile Ala Ser Thr Gly Glu His His Pro Gly Pro Arg Val Met Leu 
65                  70                  75                  80  


Asp Ala His Met Asp Glu Val Gly Leu Met Val Thr His Ile Gly Glu 
                85                  90                  95      


Gly Arg Glu Glu Gly Gly Leu Leu Arg Phe Arg Pro Leu Gly Gly Val 
            100                 105                 110         


Asp Pro Arg Val Leu Val Ser Lys Pro Val Leu Ile Gly Glu Arg Arg 
        115                 120                 125             


Ile Pro Gly Val Ile Gly Ala Lys Pro Val His Leu Gln Gln Pro Ser 
    130                 135                 140                 


Glu Arg Glu Lys Pro Ile Pro Met Glu Lys Leu Tyr Ile Asp Ile Gly 
145                 150                 155                 160 


Ala Arg Asp Ala Asp Asp Ala Arg Arg His Val Lys Pro Gly Asp Pro 
                165                 170                 175     


Val Val Phe Ala Thr Ala Tyr Gln Glu Leu Pro His Arg Met Ala Lys 
            180                 185                 190         


Ala Lys Ser Phe Asp Asp Arg Val Gly Cys Tyr Ile Leu Leu Glu Ala 
        195                 200                 205             


Leu Arg Arg Trp Lys Gly Ala Leu Pro Val Phe Gly Ala Phe Thr Val 
    210                 215                 220                 


Gln Glu Glu Ile Gly Leu Arg Gly Ala His Ala Ala Ala Tyr Gln Ile 
225                 230                 235                 240 


Glu Pro Asp Ile Ala Ile Ala Leu Glu Gly Thr Val Ala His Asp Val 
                245                 250                 255     


Val Gly Thr Pro Ser His Gly Gln Ser Thr Val Val Gly Lys Gly Pro 
            260                 265                 270         


Ala Ile Thr Val Gln Asp Gly Gln Thr Val Ala Asn Arg Arg Phe Ala 
        275                 280                 285             


Glu Phe Leu Trp Glu Thr Ala Lys Ala Arg Asn Ile Pro Val Gln Trp 
    290                 295                 300                 


Arg Arg Val Lys Gly Gly Thr Asn Asp Phe Gly Ala Ile His Arg Val 
305                 310                 315                 320 


Gly Lys Gly Val Leu Gly Gly Ala Ile Ser Val Pro Val Arg Tyr Ile 
                325                 330                 335     


His Ala Pro Thr Gln Val Val Ser Leu Asp Asp Val Ser His Ala Ile 
            340                 345                 350         


Asp Leu Val Val Ala Val Leu Asp Glu Ile Ala Lys Gly Gly Phe Arg 
        355                 360                 365             


Pro 
    


<210>  150
<211>  369
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:136 and encoded by SEQ ID NO:145

<400>  150

Met Ala Val Arg Ala Thr Pro Arg Pro Leu Leu Gly Gly Gly Arg Arg 
1               5                   10                  15      


Arg Ala Gly Gly Gly Val Asp Met Leu Leu Lys Glu Leu Thr Glu Ala 
            20                  25                  30          


Phe Gly Pro Thr Gly Phe Glu Asp Glu Val Arg Gly Ile Ile Arg Arg 
        35                  40                  45              


Glu Leu Asp Ala Met Gly Leu Ser Val Arg Thr Asp Val Leu Gly Asn 
    50                  55                  60                  


Val Ile Ala Ser Thr Gly Glu His His Pro Gly Pro Arg Val Met Leu 
65                  70                  75                  80  


Asp Ala His Met Asp Glu Val Gly Leu Met Val Thr His Ile Gly Glu 
                85                  90                  95      


Gly Arg Glu Glu Gly Gly Leu Leu Arg Phe Arg Pro Leu Gly Gly Val 
            100                 105                 110         


Asp Pro Arg Val Leu Val Ser Lys Pro Val Leu Ile Gly Glu Arg Arg 
        115                 120                 125             


Ile Pro Gly Val Ile Gly Ala Lys Pro Val His Leu Gln Gln Pro Ser 
    130                 135                 140                 


Glu Arg Glu Lys Pro Ile Pro Met Glu Lys Leu Tyr Ile Asp Ile Gly 
145                 150                 155                 160 


Ala Arg Asp Ala Asp Asp Ala Arg Arg His Val Lys Pro Gly Asp Pro 
                165                 170                 175     


Val Val Phe Ala Thr Ala Tyr Gln Glu Leu Pro His Arg Met Ala Lys 
            180                 185                 190         


Ala Lys Ser Phe Asp Asp Arg Val Gly Cys Tyr Ile Leu Leu Glu Ala 
        195                 200                 205             


Leu Arg Arg Trp Lys Gly Ala Leu Pro Val Phe Gly Ala Phe Thr Val 
    210                 215                 220                 


Gln Glu Glu Ile Gly Leu Arg Gly Ala His Ala Ala Ala Tyr Gln Ile 
225                 230                 235                 240 


Glu Pro Asp Ile Ala Ile Ala Leu Glu Gly Thr Val Ala His Asp Val 
                245                 250                 255     


Val Gly Thr Pro Ser His Gly Gln Ser Thr Val Val Gly Lys Gly Pro 
            260                 265                 270         


Ala Ile Thr Val Gln Asp Gly Gln Thr Val Ala Asn Arg Arg Phe Ala 
        275                 280                 285             


Glu Phe Leu Trp Glu Thr Ala Lys Ala Arg Asn Ile Pro Val Gln Trp 
    290                 295                 300                 


Arg Arg Val Lys Gly Gly Thr Asn Asp Phe Gly Ala Ile His Arg Val 
305                 310                 315                 320 


Gly Lys Gly Val Leu Gly Gly Ala Ile Ser Val Pro Val Arg Tyr Ile 
                325                 330                 335     


His Ala Pro Thr Gln Val Val Ser Leu Asp Asp Val Ser His Ala Ile 
            340                 345                 350         


Asp Leu Val Val Ala Val Leu Asp Glu Ile Ala Lys Gly Gly Phe Arg 
        355                 360                 365             


Pro 
    


<210>  151
<211>  369
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:136 and encoded by SEQ ID NO:146

<400>  151

Met Ala Val Arg Ala Thr Pro Arg Pro Leu Leu Gly Gly Gly Arg Arg 
1               5                   10                  15      


Arg Ala Gly Gly Gly Val Asp Met Leu Leu Lys Glu Leu Thr Glu Ala 
            20                  25                  30          


Phe Gly Pro Thr Gly Phe Glu Asp Glu Val Arg Gly Ile Val Arg Arg 
        35                  40                  45              


Glu Leu Asp Ala Met Gly Leu Ser Val Arg Thr Asp Val Leu Gly Asn 
    50                  55                  60                  


Val Ile Ala Ser Thr Gly Glu His His Pro Gly Pro Arg Val Met Leu 
65                  70                  75                  80  


Asp Ala His Met Asp Glu Val Gly Leu Met Val Thr His Ile Gly Glu 
                85                  90                  95      


Gly Arg Glu Glu Gly Gly Val Leu Arg Phe Arg Pro Leu Gly Gly Val 
            100                 105                 110         


Asp Pro Arg Val Leu Val Ser Lys Pro Val Leu Ile Gly Glu Arg Arg 
        115                 120                 125             


Ile Pro Gly Val Ile Gly Ala Lys Pro Val His Leu Gln Gln Pro Ser 
    130                 135                 140                 


Glu Arg Glu Lys Pro Ile Pro Met Glu Lys Leu Tyr Ile Asp Ile Gly 
145                 150                 155                 160 


Ala Arg Asp Ala Asp Asp Ala Arg Arg His Val Lys Pro Gly Asp Pro 
                165                 170                 175     


Val Val Phe Ala Thr Ala Tyr Gln Glu Leu Pro His Arg Met Ala Lys 
            180                 185                 190         


Ala Lys Ser Phe Asp Asp Arg Val Gly Cys Tyr Ile Leu Leu Glu Ala 
        195                 200                 205             


Leu Arg Arg Trp Lys Gly Ala Leu Pro Val Phe Gly Ala Phe Thr Val 
    210                 215                 220                 


Gln Glu Glu Ile Gly Leu Arg Gly Ala His Ala Ala Ala Tyr Gln Ile 
225                 230                 235                 240 


Glu Pro Asp Ile Ala Ile Ala Leu Glu Gly Thr Val Ala His Asp Val 
                245                 250                 255     


Val Gly Thr Pro Ser His Gly Gln Ser Thr Val Val Gly Lys Gly Pro 
            260                 265                 270         


Ala Ile Thr Val Gln Asp Gly Gln Thr Val Ala Asn Arg Arg Phe Ala 
        275                 280                 285             


Glu Phe Leu Trp Glu Thr Ala Lys Ala Arg Asn Ile Pro Val Gln Trp 
    290                 295                 300                 


Arg Arg Val Lys Gly Gly Thr Asn Asp Phe Gly Ala Ile His Arg Val 
305                 310                 315                 320 


Gly Lys Gly Val Leu Gly Gly Ala Ile Ser Val Pro Val Arg Tyr Ile 
                325                 330                 335     


His Ala Pro Thr Gln Val Val Ser Leu Asp Asp Val Ser His Ala Ile 
            340                 345                 350         


Asp Leu Val Val Ala Val Leu Asp Glu Ile Ala Lys Gly Gly Phe Arg 
        355                 360                 365             


Pro 
    


<210>  152
<211>  984
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  152
atgagggact gggtgatgcg gttgatcgac ttcgtcgcgc cgagcgggag cgaggaggcc     60

gtggtccaat cgctgttgga tcacgtccgg gaagcggcgg acgaaatctg ggtggacgcg    120

ctcggcaacg ggatcgcgcg aaagcggggc gaggggcctc acctcatgtt ggccgcgcac    180

gtcgacgagc cgggtgtcat ggtcattgac atcgacgacc gcggctatct ccgcgtggtc    240

tccgtcggag aggtgcacgc gcgcgagtgc gttggacagg aggtccgttt cacaaacggc    300

gcagtcggcc tcgtccacgc agatccggcg aagcagggcg atctcgactt cgacgcgctc    360

gtggtcgacg tcggggcgcg atcgcgcgaa gatgccgagc gcatggcgcc catcggcacg    420

gccggcgcgg tgcacgttcc cgctgcgaca tggggggaaa gcgtcgtgac gggccgagcc    480

ttggacaacc ggctgggatg cgccgtcgcc gcggaggtgt tccgcaacct cgccgctcga    540

gggttgaacg tgagcgtcgc gttcacggcg cagaacgccg tcggggcgag ggccgcgcag    600

gctgcggcgt ttcagctgga gccgcggtat gccctcgtga tcgacggggc gaccgcggac    660

gacgtgttca accatcagac ggtcctttcc ttgggcaagg ggcccgtcct gaaggtgatg    720

gaccgcggga ccgtggtgcc gctcgagggc aagcgcgccg tggagaaggc ggcggatcgg    780

ttgaaccttc tccttcagta cgaggtgtcg cgggaagcct ggagcgacac aggcgcgatt    840

caactcgcca gggcggggtg tgtggcggtc gcgctcgggt atcccgtgcg ccgcgcaggc    900

gcgttcgcga tgaccgcaga catctcggac gccgagcggc tggtggacct cgccgtggcg    960

acggtggaga cgctgttggg ctga                                           984


<210>  153
<211>  327
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  153

Met Arg Asp Trp Val Met Arg Leu Ile Asp Phe Val Ala Pro Ser Gly 
1               5                   10                  15      


Ser Glu Glu Ala Val Val Gln Ser Leu Leu Asp His Val Arg Glu Ala 
            20                  25                  30          


Ala Asp Glu Ile Trp Val Asp Ala Leu Gly Asn Gly Ile Ala Arg Lys 
        35                  40                  45              


Arg Gly Glu Gly Pro His Leu Met Leu Ala Ala His Val Asp Glu Pro 
    50                  55                  60                  


Gly Val Met Val Ile Asp Ile Asp Asp Arg Gly Tyr Leu Arg Val Val 
65                  70                  75                  80  


Ser Val Gly Glu Val His Ala Arg Glu Cys Val Gly Gln Glu Val Arg 
                85                  90                  95      


Phe Thr Asn Gly Ala Val Gly Leu Val His Ala Asp Pro Ala Lys Gln 
            100                 105                 110         


Gly Asp Leu Asp Phe Asp Ala Leu Val Val Asp Val Gly Ala Arg Ser 
        115                 120                 125             


Arg Glu Asp Ala Glu Arg Met Ala Pro Ile Gly Thr Ala Gly Ala Val 
    130                 135                 140                 


His Val Pro Ala Ala Thr Trp Gly Glu Ser Val Val Thr Gly Arg Ala 
145                 150                 155                 160 


Leu Asp Asn Arg Leu Gly Cys Ala Val Ala Ala Glu Val Phe Arg Asn 
                165                 170                 175     


Leu Ala Ala Arg Gly Leu Asn Val Ser Val Ala Phe Thr Ala Gln Asn 
            180                 185                 190         


Ala Val Gly Ala Arg Ala Ala Gln Ala Ala Ala Phe Gln Leu Glu Pro 
        195                 200                 205             


Arg Tyr Ala Leu Val Ile Asp Gly Ala Thr Ala Asp Asp Val Phe Asn 
    210                 215                 220                 


His Gln Thr Val Leu Ser Leu Gly Lys Gly Pro Val Leu Lys Val Met 
225                 230                 235                 240 


Asp Arg Gly Thr Val Val Pro Leu Glu Gly Lys Arg Ala Val Glu Lys 
                245                 250                 255     


Ala Ala Asp Arg Leu Asn Leu Leu Leu Gln Tyr Glu Val Ser Arg Glu 
            260                 265                 270         


Ala Trp Ser Asp Thr Gly Ala Ile Gln Leu Ala Arg Ala Gly Cys Val 
        275                 280                 285             


Ala Val Ala Leu Gly Tyr Pro Val Arg Arg Ala Gly Ala Phe Ala Met 
    290                 295                 300                 


Thr Ala Asp Ile Ser Asp Ala Glu Arg Leu Val Asp Leu Ala Val Ala 
305                 310                 315                 320 


Thr Val Glu Thr Leu Leu Gly 
                325         


<210>  154
<211>  327
<212>  PRT
<213>  Thermoanaerobacter tengcongensis

<400>  154

Met Ser Val Asn Val Glu Leu Ile Lys Lys Leu Thr Gln Ala Phe Gly 
1               5                   10                  15      


Pro Ser Gly Ser Glu Glu Lys Val Phe Glu Ile Ile Arg Glu Glu Val 
            20                  25                  30          


Lys Gly Phe Cys Asp Glu Ile Thr His Asp Ala Met Gly Asn Met Ile 
        35                  40                  45              


Cys Val Lys Lys Gly Lys Gly Lys Lys Ile Met Val Ala Ala His Ala 
    50                  55                  60                  


Asp Glu Ile Gly Ile Met Val Thr His Ile Glu Glu Glu Gly Phe Leu 
65                  70                  75                  80  


Arg Phe Thr Thr Ile Gly Gly Val Tyr Val Glu His Leu Val Gly Arg 
                85                  90                  95      


Arg Val Lys Phe Lys Asn Gly Thr Val Gly Val Ile Gly Val Glu His 
            100                 105                 110         


Leu Glu Asp Lys Lys Asp Phe Lys Leu Glu Lys Leu Tyr Ile Asp Ile 
        115                 120                 125             


Gly Ala Lys Asp Lys Lys Glu Ala Glu Glu Leu Val Lys Ile Gly Glu 
    130                 135                 140                 


Ser Gly Ser Phe Val Gly Glu Phe Val Glu Ala Gly Asp Arg Leu Ile 
145                 150                 155                 160 


Ser Lys Ala Phe Asp Asp Arg Ile Gly Cys Tyr Val Ala Ile Glu Ala 
                165                 170                 175     


Leu Lys Asn Val Lys Thr Glu Asn Glu Leu Tyr Phe Val Phe Thr Val 
            180                 185                 190         


Gln Glu Glu Val Gly Leu Arg Gly Ala Thr Thr Ala Ala Tyr Ser Ile 
        195                 200                 205             


Asn Pro Asp Phe Ala Ile Ala Val Asp Val Thr Ala Thr Gly Asp Thr 
    210                 215                 220                 


Pro Lys Ala Lys Lys Met Ala Val Ala Leu Gly Lys Gly Ala Ala Ile 
225                 230                 235                 240 


Lys Val Met Asp Arg Ser Ile Ile Val Ser Pro Ser Val Arg Asp Met 
                245                 250                 255     


Met Ile Glu Val Ala Lys Glu Asn Ser Ile Pro Tyr Gln Leu Glu Ile 
            260                 265                 270         


Leu Glu Phe Gly Gly Thr Asp Ala Gly Ala Ile His Leu Ser Arg Gly 
        275                 280                 285             


Gly Val Pro Ser Gly Val Ile Ser Ile Pro Thr Arg Tyr Val His Ser 
    290                 295                 300                 


Val Ser Glu Met Val Asp Lys Lys Asp Val Glu Ala Ser Ile Asn Leu 
305                 310                 315                 320 


Leu Ile Lys Ile Leu Glu Lys 
                325         


<210>  155
<211>  327
<212>  PRT
<213>  Thermoanaerobacter ethanolicus 

<400>  155

Met Ser Val Asn Val Glu Leu Ile Lys Lys Leu Thr Gln Ala Phe Gly 
1               5                   10                  15      


Pro Ser Gly Ser Glu Glu Lys Val Phe Glu Ile Ile Arg Glu Glu Val 
            20                  25                  30          


Lys Gly Phe Cys Asp Glu Ile Thr His Asp Ala Met Gly Asn Met Ile 
        35                  40                  45              


Cys Val Lys Lys Gly Lys Gly Lys Lys Ile Met Val Ala Ala His Ala 
    50                  55                  60                  


Asp Glu Ile Gly Ile Met Val Thr His Ile Glu Glu Glu Gly Phe Leu 
65                  70                  75                  80  


Arg Phe Thr Thr Ile Gly Gly Val Tyr Val Glu His Leu Val Gly Arg 
                85                  90                  95      


Arg Val Val Phe Lys Asn Gly Thr Val Gly Val Ile Gly Val Glu His 
            100                 105                 110         


Leu Glu Asp Lys Lys Asp Phe Lys Leu Glu Lys Leu Tyr Ile Asp Ile 
        115                 120                 125             


Gly Ala Lys Asp Lys Lys Glu Ala Glu Glu Leu Val Arg Ile Gly Asp 
    130                 135                 140                 


Ser Gly Ala Phe Val Gly Glu Phe Val Glu Ala Gly Asp Arg Leu Val 
145                 150                 155                 160 


Ser Lys Ala Phe Asp Asp Arg Ile Gly Cys Tyr Val Ala Ile Glu Ala 
                165                 170                 175     


Leu Lys Asn Val Lys Thr Glu Asn Glu Leu Tyr Phe Val Phe Thr Val 
            180                 185                 190         


Gln Glu Glu Val Gly Leu Arg Gly Ala Thr Thr Ala Ala Tyr Ser Ile 
        195                 200                 205             


Asn Pro Asp Phe Ala Ile Ala Val Asp Val Thr Ala Thr Gly Asp Thr 
    210                 215                 220                 


Pro Lys Ala Lys Lys Met Ala Val Ala Leu Gly Lys Gly Ala Ala Ile 
225                 230                 235                 240 


Lys Val Met Asp Arg Ser Ile Ile Val Ser Pro Ser Val Arg Asp Met 
                245                 250                 255     


Met Ile Glu Val Ala Lys Glu Asn Asn Ile Pro Tyr Gln Leu Glu Ile 
            260                 265                 270         


Leu Glu Phe Gly Gly Thr Asp Ala Gly Ala Ile His Leu Ser Arg Gly 
        275                 280                 285             


Gly Val Pro Ser Gly Val Ile Ser Ile Pro Thr Arg Tyr Val His Ser 
    290                 295                 300                 


Val Ser Glu Met Val Asp Lys Asn Asp Val Glu Ala Ser Ile Asn Leu 
305                 310                 315                 320 


Leu Ile Lys Ile Leu Glu Lys 
                325         


<210>  156
<211>  325
<212>  PRT
<213>  Clostridium thermocellum 

<400>  156

Met Phe Asp Leu Leu Lys Lys Phe Thr Gly Ile Val Gly Val Ser Gly 
1               5                   10                  15      


Asn Glu Glu Glu Ile Arg Glu Ala Ile Ile Glu Glu Ile Lys Glu Cys 
            20                  25                  30          


Val Asp Glu Ile Lys Val Asp Thr Leu Gly Asn Leu Ile Ala Val Lys 
        35                  40                  45              


Lys Gly Lys Gly Lys Lys Ile Met Val Ala Ala His Met Asp Glu Ile 
    50                  55                  60                  


Gly Val Met Val Thr Tyr Ile Asp Asp Lys Gly Phe Leu Arg Phe Ser 
65                  70                  75                  80  


Ala Val Gly Gly Val Ser Arg Tyr Asp Cys Ile Gly Gln Arg Val Lys 
                85                  90                  95      


Phe Lys Asn Gly Val Val Gly Ala Val Tyr Tyr Glu Glu Lys Leu Glu 
            100                 105                 110         


Asp Met Lys Asn Leu Gln Leu Ser Lys Met Tyr Ile Asp Ile Gly Ala 
        115                 120                 125             


Arg Ser Arg Glu Glu Ala Leu Lys Met Val Asn Ile Gly Asp Val Ala 
    130                 135                 140                 


Cys Phe Val Gly Asp Ala Val Leu Gln Gly Asp Thr Val Ile Ser Lys 
145                 150                 155                 160 


Ala Leu Asp Asn Arg Ser Gly Cys Ala Val Val Val Lys Ala Ile Lys 
                165                 170                 175     


Glu Leu Lys Lys Thr Asp Asn Glu Ile Tyr Phe Val Phe Thr Val Gln 
            180                 185                 190         


Glu Glu Val Gly Leu Arg Gly Ala Lys Thr Ala Ala Phe Ser Ile Lys 
        195                 200                 205             


Pro Asp Ile Ala Ile Ala Val Asp Val Thr Met Thr Gly Asp Thr Pro 
    210                 215                 220                 


Glu Ser His Pro Met Glu Val Lys Cys Gly Gly Gly Pro Ala Ile Lys 
225                 230                 235                 240 


Val Lys Asp Arg Ser Val Ile Cys His Pro Glu Val Arg Lys Leu Leu 
                245                 250                 255     


Glu Glu Ser Ala Lys Arg Asn Asn Ile Pro Tyr Gln Leu Glu Ile Leu 
            260                 265                 270         


Glu Ala Gly Gly Ser Asp Pro Gly Ser Ile His Leu Thr Ala Gly Gly 
        275                 280                 285             


Ile Pro Ser Gly Ala Ile Ser Ile Pro Val Arg Tyr Val His Ser Pro 
    290                 295                 300                 


Val Glu Thr Ala Ser Met Ser Asp Ile Asn Asn Ala Val Lys Leu Leu 
305                 310                 315                 320 


Val Glu Ala Ile Cys 
                325 


<210>  157
<211>  984
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 152

<400>  157
atgagggact ggctgatgcg gttgatcgac ttcgtcgcgc cgagcgggag cgaggaggcc     60

gtggtccaat cgctgttgga tcacgtccgg gaagcggcgg acgaaatctg ggtggacgcg    120

ctcggcaacg ggatcgcgcg aaagcggggc gaggggcctc acctcatgtt ggccgcgcac    180

gtcgacgagc cgggtgtcat ggtcattgac atcgacgacc gcggctatct ccgcgtggtc    240

tccgtcggag aggtgcacgc gcgcgagtgc gttggacagg aggtccgttt cacaaacggc    300

gcagtcggcc tcgtccacgc agatccggcg aagcagggcg atctcgactt cgacgcgctc    360

gtggtcgacg tcggggcgcg atcgcgcgaa gatgccgagc gcatggcgcc catcggcacg    420

gccggcgcgg tgcacgttcc cgctgcgaca tggggggaaa gcgtcgtgac gggccgagcc    480

ttggacaacc ggctgggatg cgccgtcgcc gcggaggtgt tccgcaacct cgccgctcga    540

gggttgaacg tgagcgtcgc gttcacggcg cagaacgccg tcggggcgag ggccgcgcag    600

gctgcggcgt ttcagctgga gccgcggtat gccctcgtga tcgacggggc gaccgcggac    660

gacgtgttca accatcagac ggtcctttcc ttgggcaagg ggcccgtcct gaaggtgatg    720

gaccgcggga ccgtggtgcc gctcgagggc aagcgcgccg tggagaaggc ggcggatcgg    780

ttgaaccttc tccttcagta cgaggtgtcg cgggaagcct ggagcgacac aggcgcgatt    840

caactcgcca gggcggggtg tgtggcggtc gcgctcgggt atcccgtgcg ccgcgcaggc    900

gcgttcgcga tgaccgcaga catctcggac gccgagcggc tggtggacct cgccgtggcg    960

acggtggaga cgctgttggg ctga                                           984


<210>  158
<211>  984
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 152

<400>  158
atgagggact ggataatgcg gttgatcgac ttcgtcgcgc cgagcgggag cgaggaggcc     60

gtggtccaat cgctgttgga tcacgtccgg gaagcggcgg acgaaatctg ggtggacgcg    120

ctcggcaacg ggatcgcgcg aaagcggggc gaggggcctc acctcatgtt ggccgcgcac    180

gtcgacgagc cgggtgtcat ggtcattgac atcgacgacc gcggctatct ccgcgtggtc    240

tccgtcggag aggtgcacgc gcgcgagtgc gttggacagg aggtccgttt cacaaacggc    300

gcagtcggcc tcgtccacgc agatccggcg aagcagggcg atctcgactt cgacgcgctc    360

gtggtcgacg tcggggcgcg atcgcgcgaa gatgccgagc gcatggcgcc catcggcacg    420

gccggcgcgg tgcacgttcc cgctgcgaca tggggggaaa gcgtcgtgac gggccgagcc    480

ttggacaacc ggctgggatg cgccgtcgcc gcggaggtgt tccgcaacct cgccgctcga    540

gggttgaacg tgagcgtcgc gttcacggcg cagaacgccg tcggggcgag ggccgcgcag    600

gctgcggcgt ttcagctgga gccgcggtat gccctcgtga tcgacggggc gaccgcggac    660

gacgtgttca accatcagac ggtcctttcc ttgggcaagg ggcccgtcct gaaggtgatg    720

gaccgcggga ccgtggtgcc gctcgagggc aagcgcgccg tggagaaggc ggcggatcgg    780

ttgaaccttc tccttcagta cgaggtgtcg cgggaagcct ggagcgacac aggcgcgatt    840

caactcgcca gggcggggtg tgtggcggtc gcgctcgggt atcccgtgcg ccgcgcaggc    900

gcgttcgcga tgaccgcaga catctcggac gccgagcggc tggtggacct cgccgtggcg    960

acggtggaga cgctgttggg ctga                                           984


<210>  159
<211>  984
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 152

<400>  159
atgagggact ggctgatgcg gttgctcgac ttcgtcgcgc cgagcgggag cgaggaggcc     60

gtggtccaat cgctgttgga tcacgtccgg gaagcggcgg acgaaatctg ggtggacgcg    120

ctcggcaacg ggatcgcgcg aaagcggggc gaggggcctc acctcatgtt ggccgcgcac    180

gtcgacgagc cgggtgtcat ggtcattgac atcgacgacc gcggctatct ccgcgtggtc    240

tccgtcggag aggtgcacgc gcgcgagtgc gttggacagg aggtccgttt cacaaacggc    300

gcagtcggcc tcgtccacgc agatccggcg aagcagggcg atctcgactt cgacgcgctc    360

gtggtcgacg tcggggcgcg atcgcgcgaa gatgccgagc gcatggcgcc catcggcacg    420

gccggcgcgg tgcacgttcc cgctgcgaca tggggggaaa gcgtcgtgac gggccgagcc    480

ttggacaacc ggctgggatg cgccgtcgcc gcggaggtgt tccgcaacct cgccgctcga    540

gggttgaacg tgagcgtcgc gttcacggcg cagaacgccg tcggggcgag ggccgcgcag    600

gctgcggcgt ttcagctgga gccgcggtat gccctcgtga tcgacggggc gaccgcggac    660

gacgtgttca accatcagac ggtcctttcc ttgggcaagg ggcccgtcct gaaggtgatg    720

gaccgcggga ccgtggtgcc gctcgagggc aagcgcgccg tggagaaggc ggcggatcgg    780

ttgaaccttc tccttcagta cgaggtgtcg cgggaagcct ggagcgacac aggcgcgatt    840

caactcgcca gggcggggtg tgtggcggtc gcgctcgggt atcccgtgcg ccgcgcaggc    900

gcgttcgcga tgaccgcaga catctcggac gccgagcggc tggtggacct cgccgtggcg    960

acggtggaga cgctgttggg ctga                                           984


<210>  160
<211>  984
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 152

<400>  160
atgagggact gggtgatgcg gttggtcgac ttcgtcgcgc cgagcgggag cgaggaggcc     60

gtggtccaat cgctgttgga tcacgtccgg gaagcggcgg acgaaatctg ggtggacgcg    120

ctcggcaacg ggatcgcgcg aaagcggggc gaggggcctc acctcatgtt ggccgcgcac    180

gtcgacgagc cgggtgtcat ggtcattgac atcgacgacc gcggctatct ccgcgtggtc    240

tccgtcggag aggtgcacgc gcgcgagtgc gttggacagg aggtccgttt cacaaacggc    300

gcagtcggcc tcgtccacgc agatccggcg aagcagggcg atctcgactt cgacgcgctc    360

gtggtcgacg tcggggcgcg atcgcgcgaa gatgccgagc gcatggcgcc catcggcacg    420

gccggcgcgg tgcacgttcc cgctgcgaca tggggggaaa gcgtcgtgac gggccgagcc    480

ttggacaacc ggctgggatg cgccgtcgcc gcggaggtgt tccgcaacct cgccgctcga    540

gggttgaacg tgagcgtcgc gttcacggcg cagaacgccg tcggggcgag ggccgcgcag    600

gctgcggcgt ttcagctgga gccgcggtat gccctcgtga tcgacggggc gaccgcggac    660

gacgtgttca accatcagac ggtcctttcc ttgggcaagg ggcccgtcct gaaggtgatg    720

gaccgcggga ccgtggtgcc gctcgagggc aagcgcgccg tggagaaggc ggcggatcgg    780

ttgaaccttc tccttcagta cgaggtgtcg cgggaagcct ggagcgacac aggcgcgatt    840

caactcgcca gggcggggtg tgtggcggtc gcgctcgggt atcccgtgcg ccgcgcaggc    900

gcgttcgcga tgaccgcaga catctcggac gccgagcggc tggtggacct cgccgtggcg    960

acggtggaga cgctgttggg ctga                                           984


<210>  161
<211>  984
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 152

<400>  161
atgagggact gggtgatgcg gttggtcgac ttcgtcgcgc cgagcgggag cgaggaggcc     60

gtggtcaact cgctgttgga tcacgtccgg gaagcggcgg acgaaatctg ggtggacgcg    120

ctcggcaacg ggatcgcgcg aaagcggggc gaggggcctc acctcatgtt ggccgcgcac    180

gtcgacgagc cgggtgtcat ggtcattgac atcgacgacc gcggctatct ccgcgtggtc    240

tccgtcggag aggtgcacgc gcgcgagtgc gttggacagg aggtccgttt cacaaacggc    300

gcagtcggcc tcgtccacgc agatccggcg aagcagggcg atctcgactt cgacgcgctc    360

gtggtcgacg tcggggcgcg atcgcgcgaa gatgccgagc gcatggcgcc catcggcacg    420

gccggcgcgg tgcacgttcc cgctgcgaca tggggggaaa gcgtcgtgac gggccgagcc    480

ttggacaacc ggctgggatg cgccgtcgcc gcggaggtgt tccgcaacct cgccgctcga    540

gggttgaacg tgagcgtcgc gttcacggcg cagaacgccg tcggggcgag ggccgcgcag    600

gctgcggcgt ttcagctgga gccgcggtat gccctcgtga tcgacggggc gaccgcggac    660

gacgtgttca accatcagac ggtcctttcc ttgggcaagg ggcccgtcct gaaggtgatg    720

gaccgcggga ccgtggtgcc gctcgagggc aagcgcgccg tggagaaggc ggcggatcgg    780

ttgaaccttc tccttcagta cgaggtgtcg cgggaagcct ggagcgacac aggcgcgatt    840

caactcgcca gggcggggtg tgtggcggtc gcgctcgggt atcccgtgcg ccgcgcaggc    900

gcgttcgcga tgaccgcaga catctcggac gccgagcggc tggtggacct cgccgtggcg    960

acggtggaga cgctgttggg ctga                                           984


<210>  162
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:153 and encoded by SEQ ID NO:157

<400>  162

Met Arg Asp Trp Leu Met Arg Leu Ile Asp Phe Val Ala Pro Ser Gly 
1               5                   10                  15      


Ser Glu Glu Ala Val Val Gln Ser Leu Leu Asp His Val Arg Glu Ala 
            20                  25                  30          


Ala Asp Glu Ile Trp Val Asp Ala Leu Gly Asn Gly Ile Ala Arg Lys 
        35                  40                  45              


Arg Gly Glu Gly Pro His Leu Met Leu Ala Ala His Val Asp Glu Pro 
    50                  55                  60                  


Gly Val Met Val Ile Asp Ile Asp Asp Arg Gly Tyr Leu Arg Val Val 
65                  70                  75                  80  


Ser Val Gly Glu Val His Ala Arg Glu Cys Val Gly Gln Glu Val Arg 
                85                  90                  95      


Phe Thr Asn Gly Ala Val Gly Leu Val His Ala Asp Pro Ala Lys Gln 
            100                 105                 110         


Gly Asp Leu Asp Phe Asp Ala Leu Val Val Asp Val Gly Ala Arg Ser 
        115                 120                 125             


Arg Glu Asp Ala Glu Arg Met Ala Pro Ile Gly Thr Ala Gly Ala Val 
    130                 135                 140                 


His Val Pro Ala Ala Thr Trp Gly Glu Ser Val Val Thr Gly Arg Ala 
145                 150                 155                 160 


Leu Asp Asn Arg Leu Gly Cys Ala Val Ala Ala Glu Val Phe Arg Asn 
                165                 170                 175     


Leu Ala Ala Arg Gly Leu Asn Val Ser Val Ala Phe Thr Ala Gln Asn 
            180                 185                 190         


Ala Val Gly Ala Arg Ala Ala Gln Ala Ala Ala Phe Gln Leu Glu Pro 
        195                 200                 205             


Arg Tyr Ala Leu Val Ile Asp Gly Ala Thr Ala Asp Asp Val Phe Asn 
    210                 215                 220                 


His Gln Thr Val Leu Ser Leu Gly Lys Gly Pro Val Leu Lys Val Met 
225                 230                 235                 240 


Asp Arg Gly Thr Val Val Pro Leu Glu Gly Lys Arg Ala Val Glu Lys 
                245                 250                 255     


Ala Ala Asp Arg Leu Asn Leu Leu Leu Gln Tyr Glu Val Ser Arg Glu 
            260                 265                 270         


Ala Trp Ser Asp Thr Gly Ala Ile Gln Leu Ala Arg Ala Gly Cys Val 
        275                 280                 285             


Ala Val Ala Leu Gly Tyr Pro Val Arg Arg Ala Gly Ala Phe Ala Met 
    290                 295                 300                 


Thr Ala Asp Ile Ser Asp Ala Glu Arg Leu Val Asp Leu Ala Val Ala 
305                 310                 315                 320 


Thr Val Glu Thr Leu Leu Gly 
                325         


<210>  163
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:153 and encoded by SEQ ID NO:158

<400>  163

Met Arg Asp Trp Ile Met Arg Leu Ile Asp Phe Val Ala Pro Ser Gly 
1               5                   10                  15      


Ser Glu Glu Ala Val Val Gln Ser Leu Leu Asp His Val Arg Glu Ala 
            20                  25                  30          


Ala Asp Glu Ile Trp Val Asp Ala Leu Gly Asn Gly Ile Ala Arg Lys 
        35                  40                  45              


Arg Gly Glu Gly Pro His Leu Met Leu Ala Ala His Val Asp Glu Pro 
    50                  55                  60                  


Gly Val Met Val Ile Asp Ile Asp Asp Arg Gly Tyr Leu Arg Val Val 
65                  70                  75                  80  


Ser Val Gly Glu Val His Ala Arg Glu Cys Val Gly Gln Glu Val Arg 
                85                  90                  95      


Phe Thr Asn Gly Ala Val Gly Leu Val His Ala Asp Pro Ala Lys Gln 
            100                 105                 110         


Gly Asp Leu Asp Phe Asp Ala Leu Val Val Asp Val Gly Ala Arg Ser 
        115                 120                 125             


Arg Glu Asp Ala Glu Arg Met Ala Pro Ile Gly Thr Ala Gly Ala Val 
    130                 135                 140                 


His Val Pro Ala Ala Thr Trp Gly Glu Ser Val Val Thr Gly Arg Ala 
145                 150                 155                 160 


Leu Asp Asn Arg Leu Gly Cys Ala Val Ala Ala Glu Val Phe Arg Asn 
                165                 170                 175     


Leu Ala Ala Arg Gly Leu Asn Val Ser Val Ala Phe Thr Ala Gln Asn 
            180                 185                 190         


Ala Val Gly Ala Arg Ala Ala Gln Ala Ala Ala Phe Gln Leu Glu Pro 
        195                 200                 205             


Arg Tyr Ala Leu Val Ile Asp Gly Ala Thr Ala Asp Asp Val Phe Asn 
    210                 215                 220                 


His Gln Thr Val Leu Ser Leu Gly Lys Gly Pro Val Leu Lys Val Met 
225                 230                 235                 240 


Asp Arg Gly Thr Val Val Pro Leu Glu Gly Lys Arg Ala Val Glu Lys 
                245                 250                 255     


Ala Ala Asp Arg Leu Asn Leu Leu Leu Gln Tyr Glu Val Ser Arg Glu 
            260                 265                 270         


Ala Trp Ser Asp Thr Gly Ala Ile Gln Leu Ala Arg Ala Gly Cys Val 
        275                 280                 285             


Ala Val Ala Leu Gly Tyr Pro Val Arg Arg Ala Gly Ala Phe Ala Met 
    290                 295                 300                 


Thr Ala Asp Ile Ser Asp Ala Glu Arg Leu Val Asp Leu Ala Val Ala 
305                 310                 315                 320 


Thr Val Glu Thr Leu Leu Gly 
                325         


<210>  164
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:153 and encoded by SEQ ID NO:159

<400>  164

Met Arg Asp Trp Val Met Arg Leu Leu Asp Phe Val Ala Pro Ser Gly 
1               5                   10                  15      


Ser Glu Glu Ala Val Val Gln Ser Leu Leu Asp His Val Arg Glu Ala 
            20                  25                  30          


Ala Asp Glu Ile Trp Val Asp Ala Leu Gly Asn Gly Ile Ala Arg Lys 
        35                  40                  45              


Arg Gly Glu Gly Pro His Leu Met Leu Ala Ala His Val Asp Glu Pro 
    50                  55                  60                  


Gly Val Met Val Ile Asp Ile Asp Asp Arg Gly Tyr Leu Arg Val Val 
65                  70                  75                  80  


Ser Val Gly Glu Val His Ala Arg Glu Cys Val Gly Gln Glu Val Arg 
                85                  90                  95      


Phe Thr Asn Gly Ala Val Gly Leu Val His Ala Asp Pro Ala Lys Gln 
            100                 105                 110         


Gly Asp Leu Asp Phe Asp Ala Leu Val Val Asp Val Gly Ala Arg Ser 
        115                 120                 125             


Arg Glu Asp Ala Glu Arg Met Ala Pro Ile Gly Thr Ala Gly Ala Val 
    130                 135                 140                 


His Val Pro Ala Ala Thr Trp Gly Glu Ser Val Val Thr Gly Arg Ala 
145                 150                 155                 160 


Leu Asp Asn Arg Leu Gly Cys Ala Val Ala Ala Glu Val Phe Arg Asn 
                165                 170                 175     


Leu Ala Ala Arg Gly Leu Asn Val Ser Val Ala Phe Thr Ala Gln Asn 
            180                 185                 190         


Ala Val Gly Ala Arg Ala Ala Gln Ala Ala Ala Phe Gln Leu Glu Pro 
        195                 200                 205             


Arg Tyr Ala Leu Val Ile Asp Gly Ala Thr Ala Asp Asp Val Phe Asn 
    210                 215                 220                 


His Gln Thr Val Leu Ser Leu Gly Lys Gly Pro Val Leu Lys Val Met 
225                 230                 235                 240 


Asp Arg Gly Thr Val Val Pro Leu Glu Gly Lys Arg Ala Val Glu Lys 
                245                 250                 255     


Ala Ala Asp Arg Leu Asn Leu Leu Leu Gln Tyr Glu Val Ser Arg Glu 
            260                 265                 270         


Ala Trp Ser Asp Thr Gly Ala Ile Gln Leu Ala Arg Ala Gly Cys Val 
        275                 280                 285             


Ala Val Ala Leu Gly Tyr Pro Val Arg Arg Ala Gly Ala Phe Ala Met 
    290                 295                 300                 


Thr Ala Asp Ile Ser Asp Ala Glu Arg Leu Val Asp Leu Ala Val Ala 
305                 310                 315                 320 


Thr Val Glu Thr Leu Leu Gly 
                325         


<210>  165
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:153 and encoded by SEQ ID NO:160

<400>  165

Met Arg Asp Trp Val Met Arg Leu Val Asp Phe Val Ala Pro Ser Gly 
1               5                   10                  15      


Ser Glu Glu Ala Val Val Gln Ser Leu Leu Asp His Val Arg Glu Ala 
            20                  25                  30          


Ala Asp Glu Ile Trp Val Asp Ala Leu Gly Asn Gly Ile Ala Arg Lys 
        35                  40                  45              


Arg Gly Glu Gly Pro His Leu Met Leu Ala Ala His Val Asp Glu Pro 
    50                  55                  60                  


Gly Val Met Val Ile Asp Ile Asp Asp Arg Gly Tyr Leu Arg Val Val 
65                  70                  75                  80  


Ser Val Gly Glu Val His Ala Arg Glu Cys Val Gly Gln Glu Val Arg 
                85                  90                  95      


Phe Thr Asn Gly Ala Val Gly Leu Val His Ala Asp Pro Ala Lys Gln 
            100                 105                 110         


Gly Asp Leu Asp Phe Asp Ala Leu Val Val Asp Val Gly Ala Arg Ser 
        115                 120                 125             


Arg Glu Asp Ala Glu Arg Met Ala Pro Ile Gly Thr Ala Gly Ala Val 
    130                 135                 140                 


His Val Pro Ala Ala Thr Trp Gly Glu Ser Val Val Thr Gly Arg Ala 
145                 150                 155                 160 


Leu Asp Asn Arg Leu Gly Cys Ala Val Ala Ala Glu Val Phe Arg Asn 
                165                 170                 175     


Leu Ala Ala Arg Gly Leu Asn Val Ser Val Ala Phe Thr Ala Gln Asn 
            180                 185                 190         


Ala Val Gly Ala Arg Ala Ala Gln Ala Ala Ala Phe Gln Leu Glu Pro 
        195                 200                 205             


Arg Tyr Ala Leu Val Ile Asp Gly Ala Thr Ala Asp Asp Val Phe Asn 
    210                 215                 220                 


His Gln Thr Val Leu Ser Leu Gly Lys Gly Pro Val Leu Lys Val Met 
225                 230                 235                 240 


Asp Arg Gly Thr Val Val Pro Leu Glu Gly Lys Arg Ala Val Glu Lys 
                245                 250                 255     


Ala Ala Asp Arg Leu Asn Leu Leu Leu Gln Tyr Glu Val Ser Arg Glu 
            260                 265                 270         


Ala Trp Ser Asp Thr Gly Ala Ile Gln Leu Ala Arg Ala Gly Cys Val 
        275                 280                 285             


Ala Val Ala Leu Gly Tyr Pro Val Arg Arg Ala Gly Ala Phe Ala Met 
    290                 295                 300                 


Thr Ala Asp Ile Ser Asp Ala Glu Arg Leu Val Asp Leu Ala Val Ala 
305                 310                 315                 320 


Thr Val Glu Thr Leu Leu Gly 
                325         


<210>  166
<211>  327
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:153 and encoded by SEQ ID NO:161

<400>  166

Met Arg Asp Trp Val Met Arg Leu Ile Asp Phe Val Ala Pro Ser Gly 
1               5                   10                  15      


Ser Glu Glu Ala Val Val Asn Ser Leu Leu Asp His Val Arg Glu Ala 
            20                  25                  30          


Ala Asp Glu Ile Trp Val Asp Ala Leu Gly Asn Gly Ile Ala Arg Lys 
        35                  40                  45              


Arg Gly Glu Gly Pro His Leu Met Leu Ala Ala His Val Asp Glu Pro 
    50                  55                  60                  


Gly Val Met Val Ile Asp Ile Asp Asp Arg Gly Tyr Leu Arg Val Val 
65                  70                  75                  80  


Ser Val Gly Glu Val His Ala Arg Glu Cys Val Gly Gln Glu Val Arg 
                85                  90                  95      


Phe Thr Asn Gly Ala Val Gly Leu Val His Ala Asp Pro Ala Lys Gln 
            100                 105                 110         


Gly Asp Leu Asp Phe Asp Ala Leu Val Val Asp Val Gly Ala Arg Ser 
        115                 120                 125             


Arg Glu Asp Ala Glu Arg Met Ala Pro Ile Gly Thr Ala Gly Ala Val 
    130                 135                 140                 


His Val Pro Ala Ala Thr Trp Gly Glu Ser Val Val Thr Gly Arg Ala 
145                 150                 155                 160 


Leu Asp Asn Arg Leu Gly Cys Ala Val Ala Ala Glu Val Phe Arg Asn 
                165                 170                 175     


Leu Ala Ala Arg Gly Leu Asn Val Ser Val Ala Phe Thr Ala Gln Asn 
            180                 185                 190         


Ala Val Gly Ala Arg Ala Ala Gln Ala Ala Ala Phe Gln Leu Glu Pro 
        195                 200                 205             


Arg Tyr Ala Leu Val Ile Asp Gly Ala Thr Ala Asp Asp Val Phe Asn 
    210                 215                 220                 


His Gln Thr Val Leu Ser Leu Gly Lys Gly Pro Val Leu Lys Val Met 
225                 230                 235                 240 


Asp Arg Gly Thr Val Val Pro Leu Glu Gly Lys Arg Ala Val Glu Lys 
                245                 250                 255     


Ala Ala Asp Arg Leu Asn Leu Leu Leu Gln Tyr Glu Val Ser Arg Glu 
            260                 265                 270         


Ala Trp Ser Asp Thr Gly Ala Ile Gln Leu Ala Arg Ala Gly Cys Val 
        275                 280                 285             


Ala Val Ala Leu Gly Tyr Pro Val Arg Arg Ala Gly Ala Phe Ala Met 
    290                 295                 300                 


Thr Ala Asp Ile Ser Asp Ala Glu Arg Leu Val Asp Leu Ala Val Ala 
305                 310                 315                 320 


Thr Val Glu Thr Leu Leu Gly 
                325         


<210>  167
<211>  1536
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  167
gtgacatgcg tgcacaggtg gaaacgtggt ctgtcggcag gcgcaagcct cgcgctggtc     60

gcggcagccg ccaccggttg gaccgttcac gcgcgcttcg cgcacgccga caacgtggtc    120

gatctcgtcg cgcagacggg cgatctcgac gcttctctcg cccaggtcct gcacggcgcg    180

ccgtttgcca tgcccatccc gtcgttgccg gacatcgtgc cccgcgtcta cgacatcacc    240

gagtacggcg cgaagccggg catcggccag gtgaacacac aggccattca ggcggccatc    300

gacgcggcaa gccaacacgg cggtggcatc gtcgacattc cgccggggta ttgggtcacc    360

ggtcccatcg tgctcaagag ccacgtcgat ctgaacgtgg agtccggcgc ccaactccag    420

ttttcgggcg atcacgacct gtatccgctc gttccgagcg ggaattccta catcgttcaa    480

tcgcccatca gcgcgacaaa cgcggtggat gtcgccatca cgggtcacgg cgtcatcgac    540

ggcgccggca atacgtggcg gcccgtggag aagtcgaagc tttcggcgga tcagtggaat    600

gcgctcgtgg cgtcgggtgg cgtggtgtcg ccggacggca gcacctggtg gccgacggcg    660

cagggtgcga acgcccaggc gtatatcaag gcgcatccga acatgacgta tcaggacgac    720

ttgcaggtga aggactacct gcggccgtac atggtgtact tccagggatg tcaacgcgtg    780

tggctccagg gcgtgacgtt tgaaaattcg ccgtttgcga ccgtgaaggt gaacacctcc    840

aaggacgtcg tcatcgacga cgtcaacatc cgcaacccgt ggtacgggca gaacacggac    900

ggaatcgacg tgtcggccga tgagaatgtc gtcttgtatc gcgacgtgat cgacacgggc    960

gacgacggca tcgcattgga gtcgagcggg aacgacgcgg cgggggtgtt caacgagcag   1020

gacgtcgtcg tggcggactg catcgtgcac aacggccaca gcggtttcgc cgtcggcagt   1080

tacacagacg gcggcatccg ggacgtgtgg gtgacgggtg acgtgtacga cggcacggag   1140

tcgggcctgc gcttcaagag cggcgtgggc aagggcggac tggtggagga catcgacatg   1200

gaccacatcg tcatgcggga catcagtgga gccgccatca ccttcgacga cgggtacgtg   1260

gacaacggag cggacacatc atcgcttcaa gcgcccgggc caaactcgta cgtgccgcag   1320

tttgagaaca tgaccatctc gaacgtgagt tgcgagtacg cgggccagtc catctacatg   1380

aacggcctgc cgaacgcccc tatctcgaac atcatgctgg acgacgtcaa catcacggcc   1440

aataagccgc cgcagattca gaacacctcg aaccttgtgg agaatcaggt gcagatccag   1500

tcgggcgtga ccatgctcgg cgagattccg cactga                             1536


<210>  168
<211>  511
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  168

Met Thr Cys Val His Arg Trp Lys Arg Gly Leu Ser Ala Gly Ala Ser 
1               5                   10                  15      


Leu Ala Leu Val Ala Ala Ala Ala Thr Gly Trp Thr Val His Ala Arg 
            20                  25                  30          


Phe Ala His Ala Asp Asn Val Val Asp Leu Val Ala Gln Thr Gly Asp 
        35                  40                  45              


Leu Asp Ala Ser Leu Ala Gln Val Leu His Gly Ala Pro Phe Ala Met 
    50                  55                  60                  


Pro Ile Pro Ser Leu Pro Asp Ile Val Pro Arg Val Tyr Asp Ile Thr 
65                  70                  75                  80  


Glu Tyr Gly Ala Lys Pro Gly Ile Gly Gln Val Asn Thr Gln Ala Ile 
                85                  90                  95      


Gln Ala Ala Ile Asp Ala Ala Ser Gln His Gly Gly Gly Ile Val Asp 
            100                 105                 110         


Ile Pro Pro Gly Tyr Trp Val Thr Gly Pro Ile Val Leu Lys Ser His 
        115                 120                 125             


Val Asp Leu Asn Val Glu Ser Gly Ala Gln Leu Gln Phe Ser Gly Asp 
    130                 135                 140                 


His Asp Leu Tyr Pro Leu Val Pro Ser Gly Asn Ser Tyr Ile Val Gln 
145                 150                 155                 160 


Ser Pro Ile Ser Ala Thr Asn Ala Val Asp Val Ala Ile Thr Gly His 
                165                 170                 175     


Gly Val Ile Asp Gly Ala Gly Asn Thr Trp Arg Pro Val Glu Lys Ser 
            180                 185                 190         


Lys Leu Ser Ala Asp Gln Trp Asn Ala Leu Val Ala Ser Gly Gly Val 
        195                 200                 205             


Val Ser Pro Asp Gly Ser Thr Trp Trp Pro Thr Ala Gln Gly Ala Asn 
    210                 215                 220                 


Ala Gln Ala Tyr Ile Lys Ala His Pro Asn Met Thr Tyr Gln Asp Asp 
225                 230                 235                 240 


Leu Gln Val Lys Asp Tyr Leu Arg Pro Tyr Met Val Tyr Phe Gln Gly 
                245                 250                 255     


Cys Gln Arg Val Trp Leu Gln Gly Val Thr Phe Glu Asn Ser Pro Phe 
            260                 265                 270         


Ala Thr Val Lys Val Asn Thr Ser Lys Asp Val Val Ile Asp Asp Val 
        275                 280                 285             


Asn Ile Arg Asn Pro Trp Tyr Gly Gln Asn Thr Asp Gly Ile Asp Val 
    290                 295                 300                 


Ser Ala Asp Glu Asn Val Val Leu Tyr Arg Asp Val Ile Asp Thr Gly 
305                 310                 315                 320 


Asp Asp Gly Ile Ala Leu Glu Ser Ser Gly Asn Asp Ala Ala Gly Val 
                325                 330                 335     


Phe Asn Glu Gln Asp Val Val Val Ala Asp Cys Ile Val His Asn Gly 
            340                 345                 350         


His Ser Gly Phe Ala Val Gly Ser Tyr Thr Asp Gly Gly Ile Arg Asp 
        355                 360                 365             


Val Trp Val Thr Gly Asp Val Tyr Asp Gly Thr Glu Ser Gly Leu Arg 
    370                 375                 380                 


Phe Lys Ser Gly Val Gly Lys Gly Gly Leu Val Glu Asp Ile Asp Met 
385                 390                 395                 400 


Asp His Ile Val Met Arg Asp Ile Ser Gly Ala Ala Ile Thr Phe Asp 
                405                 410                 415     


Asp Gly Tyr Val Asp Asn Gly Ala Asp Thr Ser Ser Leu Gln Ala Pro 
            420                 425                 430         


Gly Pro Asn Ser Tyr Val Pro Gln Phe Glu Asn Met Thr Ile Ser Asn 
        435                 440                 445             


Val Ser Cys Glu Tyr Ala Gly Gln Ser Ile Tyr Met Asn Gly Leu Pro 
    450                 455                 460                 


Asn Ala Pro Ile Ser Asn Ile Met Leu Asp Asp Val Asn Ile Thr Ala 
465                 470                 475                 480 


Asn Lys Pro Pro Gln Ile Gln Asn Thr Ser Asn Leu Val Glu Asn Gln 
                485                 490                 495     


Val Gln Ile Gln Ser Gly Val Thr Met Leu Gly Glu Ile Pro His 
            500                 505                 510     


<210>  169
<211>  443
<212>  PRT
<213>  Bacillus NRRL B-14911

<400>  169

Met Ala Val Tyr His Ile Ser Glu Tyr Leu Lys Gly Asn Ala Gly Leu 
1               5                   10                  15      


Ala Thr Glu Gly Ile Gln Lys Ala Ile Asp Glu Ala Tyr Gln Asn Gly 
            20                  25                  30          


Gly Gly Lys Val Val Ile Pro Ala Gly Glu Phe Leu Thr Gly Pro Leu 
        35                  40                  45              


Phe Leu Lys Asp Asn Ile Glu Leu His Leu Glu Asn Gly Ala His Leu 
    50                  55                  60                  


Lys Phe Ser Asp Lys Gln Glu Asp Tyr Pro Val Val Thr Ser Arg Trp 
65                  70                  75                  80  


Glu Gly Val Lys Arg Lys Val Tyr Ala Ser Cys Leu Phe Ala Glu Gly 
                85                  90                  95      


Ala Arg Asn Ile Ala Val Thr Gly Phe Gly Thr Ile Asp Gly Asn Gly 
            100                 105                 110         


Met Glu Trp Trp Asp Val Phe Arg Asn Arg Arg Glu Glu Leu Lys Tyr 
        115                 120                 125             


Pro Arg Pro Lys Leu Ile Ser Phe Asp His Cys Glu His Ile Thr Leu 
    130                 135                 140                 


Arg Asp Val Arg Leu Ile Asn Ser Pro Ser Trp Thr Val Asn Pro Ile 
145                 150                 155                 160 


Cys Cys Arg Asp Ile Thr Val Asp Asn Val Ser Ile Leu Asn Pro Ala 
                165                 170                 175     


Asp Ser Pro Asn Thr Asp Gly Ile Asp Pro Glu Ser Cys Arg Asn Val 
            180                 185                 190         


Arg Ile Ser Asn Cys His Ile Asp Val Gly Asp Asp Cys Ile Ala Ile 
        195                 200                 205             


Lys Ser Gly Thr Glu Asp Thr Glu Glu Arg Val Ala Cys Glu Asn Ile 
    210                 215                 220                 


Thr Ile Thr Asn Cys Thr Met Val His Gly His Gly Ala Val Val Phe 
225                 230                 235                 240 


Gly Ser Glu Met Ser Gly Asp Ile Arg Asn Val Thr Ile Ser Asn Cys 
                245                 250                 255     


Val Phe Gln Asp Thr Asp Arg Gly Ile Arg Phe Lys Ser Arg Arg Gly 
            260                 265                 270         


Arg Gly Gly Val Val Glu Asp Val Arg Val Asp Asn Ile Val Met Glu 
        275                 280                 285             


Gly Val Ile Cys Pro Phe Ile Ile Asn Leu Tyr Tyr Phe Cys Gly Pro 
    290                 295                 300                 


Arg Gly Lys Asp Gln Tyr Val Trp Asp Lys Asn Pro Tyr Pro Val Thr 
305                 310                 315                 320 


Ala Glu Thr Pro Met Phe Arg Arg Leu His Phe Ala Asn Ile Thr Ala 
                325                 330                 335     


Arg Asn Val His Ala Ser Ala Gly Tyr Ile Tyr Gly Leu Ala Glu Gln 
            340                 345                 350         


Tyr Ala Thr Asp Ile Thr Phe Ser Gln Ile Asp Ile Ser Leu Ala Lys 
        355                 360                 365             


Asn Ala Val Pro Gly Lys Pro Ala Met Met Ala Gly Ile Glu Asp Met 
    370                 375                 380                 


Ala Asn Arg Gly Phe Tyr Val Gly Phe Ala Lys Asp Val Leu Phe Ser 
385                 390                 395                 400 


Arg Val Thr Ile Glu Asn His Glu Gly Pro Ala Phe His Ile Glu His 
                405                 410                 415     


Ser Glu Asp Val Glu Val Ile Ser Cys Lys Ser Arg Asn Thr Lys Glu 
            420                 425                 430         


Gly Glu Glu Leu Val Arg Glu Val Ala Ala Lys 
        435                 440             


<210>  170
<211>  446
<212>  PRT
<213>  Solibacter usitatus 

<400>  170

Met Lys Ser Thr Cys Arg Val Ala Leu Val Gly Leu Leu Ala Ala Cys 
1               5                   10                  15      


Ala Trp Ser Ala Glu Phe Asp Val Lys Thr Phe Gly Ala Ala Gly Asp 
            20                  25                  30          


Gly Lys Lys Lys Asp Thr Ala Ala Ile Ala Arg Ala Ile Asp Ala Ala 
        35                  40                  45              


Ala Lys Ala Gly Gly Gly Thr Val Val Val Ser Pro Gly Arg Tyr Leu 
    50                  55                  60                  


Thr Gly Ala Leu Thr Leu Lys Ser Asn Val Thr Leu Asp Val Glu Ala 
65                  70                  75                  80  


Gly Ala Thr Leu Leu Gly Ser Pro Asp Pro Glu Asp Tyr Pro Leu Arg 
                85                  90                  95      


Glu Asn Val Trp Gly Glu Lys Lys Glu Tyr Ser Ser Leu Ile Tyr Ala 
            100                 105                 110         


Asp Gly Ala Val His Ile Thr Ile Arg Gly Arg Gly Thr Ile Asp Gly 
        115                 120                 125             


Gln Gly Gln Ala Trp Trp Lys Arg Met Gly Trp Pro Asp Arg Arg Lys 
    130                 135                 140                 


Ile Ala Pro Glu Gln Arg Thr Ala Ala Glu Arg Ala Glu Leu Ala Lys 
145                 150                 155                 160 


Leu Glu Tyr Gly Arg Pro His Met Ile Lys Leu Val Arg Ser Lys His 
                165                 170                 175     


Val Val Ile Glu Gly Leu His Leu Ile Asn Ser Ala Ser Trp Thr Val 
            180                 185                 190         


Asn Pro Leu Leu Cys Glu Phe Val Arg Ile Asp Gly Ile Thr Ile Glu 
        195                 200                 205             


Asn Pro Val Pro Ser Pro Asn Thr Asp Gly Ile Asn Pro Glu Ser Cys 
    210                 215                 220                 


Arg Asn Val Gln Ile Leu Asn Ser Arg Ile Asp Val Gly Asp Asp Cys 
225                 230                 235                 240 


Val Thr Leu Lys Ser Gly Lys Asp Glu Ala Gly Arg Arg Val Gly Arg 
                245                 250                 255     


Pro Asp Glu Asn Ile Thr Ile Thr Asn Cys Val Met Leu Lys Gly His 
            260                 265                 270         


Gly Ala Val Thr Ile Gly Ser Glu Met Ser Gly Gly Val Arg Asn Val 
        275                 280                 285             


Val Val Ser Asn Cys Val Phe Gln Gly Thr Asp Val Gly Ile Arg Val 
    290                 295                 300                 


Lys Ser Gln Arg Gly Arg Gly Gly Ile Val Glu Gly Phe Val Val Ser 
305                 310                 315                 320 


Asn Val Val Met Gln Asp Val Ala Ser Ala Phe Thr Leu Thr Ser Phe 
                325                 330                 335     


Tyr Ala Gly Thr Asp Lys Pro Gly Asp Leu Phe Pro Val Gly Glu Gly 
            340                 345                 350         


Thr Pro Arg Leu Arg Asp Phe Arg Phe Ser Asn Ile Thr Ala Arg Gly 
        355                 360                 365             


Ser Lys Thr Ala Gly Gln Ile Thr Gly Leu Lys Glu Met Pro Ile Glu 
    370                 375                 380                 


Asn Ile Thr Phe Thr Gly Val Arg Ile Gln Ala Glu Thr Gly Met Lys 
385                 390                 395                 400 


Ile Thr Asn Ala Lys Asp Val Thr Phe Gln Asp Val Ile Ile Glu Ala 
                405                 410                 415     


Ala Lys Gly Asp Ala Val Ser Val Val Asp Ser Val Gly Ile Glu Leu 
            420                 425                 430         


Gly Arg Leu Lys Gly Arg Ala Ala Thr Val Arg Glu Arg Pro 
        435                 440                 445     


<210>  171
<211>  436
<212>  PRT
<213>  Bacillus licheniformis

<400>  171

Met Ser Leu Gln Lys Ile Lys Glu Glu Ile Val Lys Lys Leu Lys Val 
1               5                   10                  15      


Pro Val Phe Pro Asn Arg Ser Phe Asp Val Thr Ser Phe Gly Ala Asp 
            20                  25                  30          


Glu Asn Gly Lys Asn Asp Ser Thr Glu Ala Ile Gln Lys Ala Ile Asp 
        35                  40                  45              


Gln Ala His Gln Ala Gly Gly Gly Arg Val Thr Val Pro Glu Gly Val 
    50                  55                  60                  


Phe Leu Ser Gly Ala Leu Arg Leu Lys Ser Asn Val Asp Leu His Ile 
65                  70                  75                  80  


Ala Lys Gly Ala Val Ile Lys Phe Ser Gln Asn Pro Glu Asp Tyr Leu 
                85                  90                  95      


Pro Val Val Leu Thr Arg Phe Glu Gly Val Glu Leu Tyr Asn Tyr Ser 
            100                 105                 110         


Pro Leu Ile Tyr Ala Tyr Glu Ala Asp Asn Ile Ala Ile Thr Gly Lys 
        115                 120                 125             


Gly Thr Leu Asp Gly Gln Gly Asp Asp Glu His Trp Trp Pro Trp Lys 
    130                 135                 140                 


Arg Gly Thr Asn Gly Gln Pro Ser Gln Glu Lys Asp Arg Asn Ala Leu 
145                 150                 155                 160 


Phe Glu Met Ala Glu Arg Gly Ile Pro Val Thr Glu Arg Gln Phe Gly 
                165                 170                 175     


Lys Gly His Tyr Leu Arg Pro Asn Phe Ile Gln Pro Tyr Arg Cys Lys 
            180                 185                 190         


His Ile Leu Ile Gln Gly Val Thr Val Leu Asn Ser Pro Met Trp Gln 
        195                 200                 205             


Val His Pro Val Leu Cys Glu Asn Val Thr Val Asp Gly Ile Lys Val 
    210                 215                 220                 


Ile Gly His Gly Pro Asn Thr Asp Gly Val Asn Pro Glu Ser Cys Lys 
225                 230                 235                 240 


Asn Val Val Ile Lys Gly Cys His Phe Asp Asn Gly Asp Asp Cys Ile 
                245                 250                 255     


Ala Val Lys Ser Gly Arg Asn Ala Asp Gly Arg Arg Ile Asn Ile Pro 
            260                 265                 270         


Ser Glu Asn Ile Val Ile Glu His Asn Glu Met Lys Asp Gly His Gly 
        275                 280                 285             


Gly Val Thr Ile Gly Ser Glu Ile Ser Gly Gly Val Lys Asn Val Ile 
    290                 295                 300                 


Ala Glu Gly Asn Leu Met Asp Ser Pro Asn Leu Asp Arg Ala Leu Arg 
305                 310                 315                 320 


Ile Lys Thr Asn Ser Val Arg Gly Gly Val Leu Glu Asn Ile Tyr Phe 
                325                 330                 335     


His Lys Asn Thr Val Lys Ser Leu Lys Arg Glu Val Ile Ala Ile Asp 
            340                 345                 350         


Met Glu Tyr Glu Glu Gly Asp Ala Gly Asp Phe Lys Pro Val Val Arg 
        355                 360                 365             


Thr Val Asp Val Lys Gln Leu Lys Ser Met Gly Gly Gln Tyr Gly Ile 
    370                 375                 380                 


Arg Val Leu Ala Tyr Asp His Ser Pro Val Thr Gly Leu Lys Val Ala 
385                 390                 395                 400 


Asp Ser Glu Ile Asp Gly Val Asp Val Pro Met Glu Leu Lys His Val 
                405                 410                 415     


Lys Asp Pro Val Phe Ser Asn Leu Tyr Ile Asn Gly Lys Arg Tyr Asp 
            420                 425                 430         


Ser His Lys Ala 
        435     


<210>  172
<211>  436
<212>  PRT
<213>  Bacillus licheniformis 

<400>  172

Met Ser Leu Gln Lys Ile Lys Glu Glu Ile Val Lys Lys Leu Lys Val 
1               5                   10                  15      


Pro Val Phe Pro Asn Arg Ser Phe Asp Val Thr Ser Phe Gly Ala Asp 
            20                  25                  30          


Glu Asn Gly Lys Asn Asp Ser Thr Glu Ala Ile Gln Lys Ala Ile Asp 
        35                  40                  45              


Gln Ala His Gln Ala Gly Gly Gly Arg Val Thr Val Pro Glu Gly Val 
    50                  55                  60                  


Phe Leu Ser Gly Ala Leu Arg Leu Lys Ser Asn Val Asp Leu His Ile 
65                  70                  75                  80  


Ala Lys Gly Ala Val Ile Lys Phe Ser Gln Asn Pro Glu Asp Tyr Leu 
                85                  90                  95      


Pro Val Val Leu Thr Arg Phe Glu Gly Val Glu Leu Tyr Asn Tyr Ser 
            100                 105                 110         


Pro Leu Ile Tyr Ala Tyr Glu Ala Asp Asn Ile Ala Ile Thr Gly Lys 
        115                 120                 125             


Gly Thr Leu Asp Gly Gln Gly Asp Asp Glu His Trp Trp Pro Trp Lys 
    130                 135                 140                 


Arg Gly Thr Asn Gly Gln Pro Ser Gln Glu Lys Asp Arg Asn Ala Leu 
145                 150                 155                 160 


Phe Glu Met Ala Glu Arg Gly Ile Pro Val Thr Glu Arg Gln Phe Gly 
                165                 170                 175     


Lys Gly His Tyr Leu Arg Pro Asn Phe Ile Gln Pro Tyr Arg Cys Lys 
            180                 185                 190         


His Ile Leu Ile Gln Gly Val Thr Val Leu Asn Ser Pro Met Trp Gln 
        195                 200                 205             


Val His Pro Val Leu Cys Glu Asn Val Thr Val Asp Gly Ile Lys Val 
    210                 215                 220                 


Ile Gly His Gly Pro Asn Thr Asp Gly Val Asn Pro Glu Ser Cys Lys 
225                 230                 235                 240 


Asn Val Val Ile Lys Gly Cys His Phe Asp Asn Gly Asp Asp Cys Ile 
                245                 250                 255     


Ala Val Lys Ser Gly Arg Asn Ala Asp Gly Arg Arg Ile Asn Ile Pro 
            260                 265                 270         


Ser Glu Asn Ile Val Ile Glu His Asn Glu Met Lys Asp Gly His Gly 
        275                 280                 285             


Gly Val Thr Ile Gly Ser Glu Ile Ser Gly Gly Val Lys Asn Val Ile 
    290                 295                 300                 


Ala Glu Gly Asn Leu Met Asp Ser Pro Asn Leu Asp Arg Ala Leu Arg 
305                 310                 315                 320 


Ile Lys Thr Asn Ser Val Arg Gly Gly Val Leu Glu Asn Ile Tyr Phe 
                325                 330                 335     


His Lys Asn Thr Val Lys Ser Leu Lys Arg Glu Val Ile Ala Ile Asp 
            340                 345                 350         


Met Glu Tyr Glu Glu Gly Asp Ala Gly Asp Phe Lys Pro Val Val Arg 
        355                 360                 365             


Thr Val Asp Val Lys Gln Leu Lys Ser Met Gly Gly Gln Tyr Gly Ile 
    370                 375                 380                 


Arg Val Leu Ala Tyr Asp His Ser Pro Val Thr Gly Leu Lys Val Ala 
385                 390                 395                 400 


Asp Ser Glu Ile Asp Gly Val Asp Val Pro Met Glu Leu Lys His Val 
                405                 410                 415     


Lys Asp Pro Val Phe Ser Asn Leu Tyr Ile Asn Gly Lys Arg Tyr Asp 
            420                 425                 430         


Ser His Lys Ala 
        435     


<210>  173
<211>  436
<212>  PRT
<213>  Solibacter usitatus

<400>  173

Met Arg Val Leu Leu Leu Leu Ile Ala Ala Leu Ala Leu Arg Ala Ala 
1               5                   10                  15      


Glu Phe Arg Val Thr Asp Tyr Gly Ala Lys Ala Asp Gly Lys Thr Val 
            20                  25                  30          


Asn Thr Val Ala Leu Gln Lys Ala Ile Asp Ala Ala Ala Lys Ala Gly 
        35                  40                  45              


Lys Gly Val Val Val Phe Ala Pro Gly Val Tyr Leu Ser Gly Ala Leu 
    50                  55                  60                  


Phe Leu Lys Ser Asn Met Glu Leu Arg Leu Asp Glu Gly Val Glu Ile 
65                  70                  75                  80  


Arg Gly Val Gln Asp Leu Ala Ala Tyr Pro Leu Met Gln Thr Arg Val 
                85                  90                  95      


Ala Gly Ile Glu Met Lys Trp Pro Ala Ala Leu Leu Asn Val Tyr Glu 
            100                 105                 110         


Gln Ser Asn Val Arg Leu Ser Gly Lys Gly Thr Val Asp Gly Asp Gly 
        115                 120                 125             


Lys Ile Trp Trp Asp Leu Tyr Trp Lys Met Arg Arg Glu Glu Tyr Glu 
    130                 135                 140                 


Pro Lys Gly Leu Arg Trp Ala Val Asp Tyr Asp Cys Arg Arg Pro Arg 
145                 150                 155                 160 


Leu Ile Gln Ile Tyr Lys Ser Gln Gly Val Asp Leu Val Ser Leu Thr 
                165                 170                 175     


Leu Lys Arg Pro Gly Phe Trp Thr Val His Ile Cys Tyr Ser Glu Arg 
            180                 185                 190         


Val Thr Val Asp Gly Leu Thr Ile Arg Asn Asn Thr Asp Gly Lys Gly 
        195                 200                 205             


Pro Ser Thr Asp Gly Ile Asp Ile Asp Ser Ser Ser Asp Val Leu Val 
    210                 215                 220                 


Ala His Cys Asp Ile Asp Cys Asn Asp Asp Ala Ile Cys Leu Lys Ala 
225                 230                 235                 240 


Gly Arg Asp Ala Asp Gly Leu Arg Val Asn Leu Pro Thr Glu Arg Val 
                245                 250                 255     


Arg Ile Thr Asp Asn Val Val Arg Gly Gly Ala Ala Gly Val Thr Ile 
            260                 265                 270         


Gly Ser Glu Thr Ser Gly Gly Ile Arg His Ile Glu Val Asp His Leu 
        275                 280                 285             


Thr Val Met Ser Ala Val Pro Ala Gly Ile Leu Phe Lys Ser Ala Ser 
    290                 295                 300                 


Thr Arg Gly Gly Thr Ile Glu Asp Ile Ala Ile Arg Asn Val Ile Thr 
305                 310                 315                 320 


Val Gly Val Ala Thr Pro Val Ser Ile Thr Leu Asn Trp Asn Pro Ala 
                325                 330                 335     


Tyr Ser Tyr Ala Lys Leu Pro Glu Gly Val Lys Asp Met Pro Asp Tyr 
            340                 345                 350         


Trp Arg Val Leu Thr Glu Val Val Pro Pro Gly Lys Gly Ile Pro His 
        355                 360                 365             


Phe Arg Asp Val Arg Ile Ser Arg Val Lys Ser Thr Gly Ala Gln Arg 
    370                 375                 380                 


Ala Phe Ala Val Ser Ser Tyr Ala Glu Ser Pro Leu Val Asp Phe Gln 
385                 390                 395                 400 


Phe Lys Asp Ile Asp Ile Glu Ala Lys Thr Ala Gly Ser Ile Ala Asn 
                405                 410                 415     


Thr Gln Gly Trp Lys Phe Glu Asn Met Thr Ile Lys Thr Ala Asp Gly 
            420                 425                 430         


Thr Thr Val Lys 
        435     


<210>  174
<211>  1536
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 167

<400>  174
gtgacatgcg tgcacaagtg gaaacgtggt ctgtcggcag gcgcaagcct cgcgctggtc     60

gcggcagccg ccaccggttg gaccgttcac gcgcgcttcg cgcacgccga caacgtggtc    120

gatctcgtcg cgcagacggg cgatctcgac gcttctctcg cccaggtcct gcacggcgcg    180

ccgtttgcca tgcccatccc gtcgttgccg gacatcgtgc cccgcgtcta cgacatcacc    240

gagtacggcg cgaagccggg catcggccag gtgaacacac aggccattca ggcggccatc    300

gacgcggcaa gccaacacgg cggtggcatc gtcgacattc cgccggggta ttgggtcacc    360

ggtcccatcg tgctcaagag ccacgtcgat ctgaacgtgg agtccggcgc ccaactccag    420

ttttcgggcg atcacgacct gtatccgctc gttccgagcg ggaattccta catcgttcaa    480

tcgcccatca gcgcgacaaa cgcggtggat gtcgccatca cgggtcacgg cgtcatcgac    540

ggcgccggca atacgtggcg gcccgtggag aagtcgaagc tttcggcgga tcagtggaat    600

gcgctcgtgg cgtcgggtgg cgtggtgtcg ccggacggca gcacctggtg gccgacggcg    660

cagggtgcga acgcccaggc gtatatcaag gcgcatccga acatgacgta tcaggacgac    720

ttgcaggtga aggactacct gcggccgtac atggtgtact tccagggatg tcaacgcgtg    780

tggctccagg gcgtgacgtt tgaaaattcg ccgtttgcga ccgtgaaggt gaacacctcc    840

aaggacgtcg tcatcgacga cgtcaacatc cgcaacccgt ggtacgggca gaacacggac    900

ggaatcgacg tgtcggccga tgagaatgtc gtcttgtatc gcgacgtgat cgacacgggc    960

gacgacggca tcgcattgga gtcgagcggg aacgacgcgg cgggggtgtt caacgagcag   1020

gacgtcgtcg tggcggactg catcgtgcac aacggccaca gcggtttcgc cgtcggcagt   1080

tacacagacg gcggcatccg ggacgtgtgg gtgacgggtg acgtgtacga cggcacggag   1140

tcgggcctgc gcttcaagag cggcgtgggc aagggcggac tggtggagga catcgacatg   1200

gaccacatcg tcatgcggga catcagtgga gccgccatca ccttcgacga cgggtacgtg   1260

gacaacggag cggacacatc atcgcttcaa gcgcccgggc caaactcgta cgtgccgcag   1320

tttgagaaca tgaccatctc gaacgtgagt tgcgagtacg cgggccagtc catctacatg   1380

aacggcctgc cgaacgcccc tatctcgaac atcatgctgg acgacgtcaa catcacggcc   1440

aataagccgc cgcagattca gaacacctcg aaccttgtgg agaatcaggt gcagatccag   1500

tcgggcgtga ccatgctcgg cgagattccg cactga                             1536


<210>  175
<211>  1536
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 167

<400>  175
gtgacatgcg tgcacaggtg gagacgtggt ctgtcggcag gcgcaagcct cgcgctggtc     60

gcggcagccg ccaccggttg gaccgttcac gcgcgcttcg cgcacgccga caacgtggtc    120

gatctcgtcg cgcagacggg cgatctcgac gcttctctcg cccaggtcct gcacggcgcg    180

ccgtttgcca tgcccatccc gtcgttgccg gacatcgtgc cccgcgtcta cgacatcacc    240

gagtacggcg cgaagccggg catcggccag gtgaacacac aggccattca ggcggccatc    300

gacgcggcaa gccaacacgg cggtggcatc gtcgacattc cgccggggta ttgggtcacc    360

ggtcccatcg tgctcaagag ccacgtcgat ctgaacgtgg agtccggcgc ccaactccag    420

ttttcgggcg atcacgacct gtatccgctc gttccgagcg ggaattccta catcgttcaa    480

tcgcccatca gcgcgacaaa cgcggtggat gtcgccatca cgggtcacgg cgtcatcgac    540

ggcgccggca atacgtggcg gcccgtggag aagtcgaagc tttcggcgga tcagtggaat    600

gcgctcgtgg cgtcgggtgg cgtggtgtcg ccggacggca gcacctggtg gccgacggcg    660

cagggtgcga acgcccaggc gtatatcaag gcgcatccga acatgacgta tcaggacgac    720

ttgcaggtga aggactacct gcggccgtac atggtgtact tccagggatg tcaacgcgtg    780

tggctccagg gcgtgacgtt tgaaaattcg ccgtttgcga ccgtgaaggt gaacacctcc    840

aaggacgtcg tcatcgacga cgtcaacatc cgcaacccgt ggtacgggca gaacacggac    900

ggaatcgacg tgtcggccga tgagaatgtc gtcttgtatc gcgacgtgat cgacacgggc    960

gacgacggca tcgcattgga gtcgagcggg aacgacgcgg cgggggtgtt caacgagcag   1020

gacgtcgtcg tggcggactg catcgtgcac aacggccaca gcggtttcgc cgtcggcagt   1080

tacacagacg gcggcatccg ggacgtgtgg gtgacgggtg acgtgtacga cggcacggag   1140

tcgggcctgc gcttcaagag cggcgtgggc aagggcggac tggtggagga catcgacatg   1200

gaccacatcg tcatgcggga catcagtgga gccgccatca ccttcgacga cgggtacgtg   1260

gacaacggag cggacacatc atcgcttcaa gcgcccgggc caaactcgta cgtgccgcag   1320

tttgagaaca tgaccatctc gaacgtgagt tgcgagtacg cgggccagtc catctacatg   1380

aacggcctgc cgaacgcccc tatctcgaac atcatgctgg acgacgtcaa catcacggcc   1440

aataagccgc cgcagattca gaacacctcg aaccttgtgg agaatcaggt gcagatccag   1500

tcgggcgtga ccatgctcgg cgagattccg cactga                             1536


<210>  176
<211>  1500
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 167

<400>  176
gtgacatgcg tgcacaggtg gaaaaaaggt ctgtcggcag gcgcaagcct cgcgctggtc     60

gcggcagccg ccaccggttg gaccgttcac gcgcgcttcg cgcacgccga caacgtggtc    120

gatctcgtcg cgcagacggg cgatctcgac gcttctctcg cccaggtcct gcacggcgcg    180

ccgtttgcca tgcccatccc gtcgttgccg gacatcgtgc cccgcgtcta cgacatcacc    240

gagtacggcg cgaagccggg catcggccag gtgaacacac aggccattca ggcggccatc    300

gacgcggcaa gccaacacgg cggtggcatc gtcgacattc cgccggggta ttgggtcacc    360

ggtcccatcg tgctcaagag ccacgtcgat ctgaacgtgg agtccggcgc ccaactccag    420

ttttcgggcg atcacgacct gtatccgctc gttccgagcg ggaattccta catcgttcaa    480

tcgcccatca gcgcgacaaa cgcggtggat gtcgccatca cgggtcacgg cgtcatcgac    540

ggcgccggca atacgtggcg gcccgtggag aagtcgaagc tttcggcgga tcagtggaat    600

gcgctcgtgg cgtcgggtgg cgtggtgtcg ccggacggca gcacctggtg gccgacggcg    660

cagggtgcga acgcccaggc gtatatcaag gcgcatccga acatgacgta tcaggacgac    720

ttgcaggtga aggactacct gcggccgtac atggtgtact tccagggatg tcaacgcgtg    780

tggctccagg gcgtgacgtt tgaaaattcg ccgtttgcga ccgtgaaggt gaacacctcc    840

aaggacgtcg tcatcgacga cgtcaacatc cgcaacccgt ggtacgggca gaacacggac    900

ggaatcgacg tgtcggccga tgagaatgtc gtcttgtatc gcgacgtgat cgacacgggc    960

gacgacggca tcgcattgga gtcgagcggg aacgacgcgg cgggggtgtt caacgagcag   1020

gacgtcgtcg tggcggactg catcgtgcac aacggccaca gcggtttcgc cgtcggcagt   1080

tacacagacg gcggcatccg ggacgtgtgg gtgacgggtg acgtgtacga cggcacggag   1140

tcgggcctgc gcttcaagag cggcgtgggc aagggcggac tggtggagga catcgacatg   1200

gaccacatcg tcatgcggga catcagtgga gccgccatca ccttcgacga cgggtacgtg   1260

gacaacggag cggacacatc atcgcttcaa gcgcccgggc caaactcgta cgtgccgcag   1320

tttgagaaca tgaccatctc gaacgtgagt tgcgagtacg cgggccagtc catctacatg   1380

aacggcctgc cgaacgcccc tatctcgaac atcatgctgg acgacgtcaa catcacggcc   1440

aataagccgc cgcagattca gaacacctcg aaccttgtgg agaatcaggt gcagatccag   1500


<210>  177
<211>  1536
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 167

<400>  177
gtgacatgcg tgcacaggtg gaaacgtggt atatcggcag gcgcaagcct cgcgctggtc     60

gcggcagccg ccaccggttg gaccgttcac gcgcgcttcg cgcacgccga caacgtggtc    120

gatctcgtcg cgcagacggg cgatctcgac gcttctctcg cccaggtcct gcacggcgcg    180

ccgtttgcca tgcccatccc gtcgttgccg gacatcgtgc cccgcgtcta cgacatcacc    240

gagtacggcg cgaagccggg catcggccag gtgaacacac aggccattca ggcggccatc    300

gacgcggcaa gccaacacgg cggtggcatc gtcgacattc cgccggggta ttgggtcacc    360

ggtcccatcg tgctcaagag ccacgtcgat ctgaacgtgg agtccggcgc ccaactccag    420

ttttcgggcg atcacgacct gtatccgctc gttccgagcg ggaattccta catcgttcaa    480

tcgcccatca gcgcgacaaa cgcggtggat gtcgccatca cgggtcacgg cgtcatcgac    540

ggcgccggca atacgtggcg gcccgtggag aagtcgaagc tttcggcgga tcagtggaat    600

gcgctcgtgg cgtcgggtgg cgtggtgtcg ccggacggca gcacctggtg gccgacggcg    660

cagggtgcga acgcccaggc gtatatcaag gcgcatccga acatgacgta tcaggacgac    720

ttgcaggtga aggactacct gcggccgtac atggtgtact tccagggatg tcaacgcgtg    780

tggctccagg gcgtgacgtt tgaaaattcg ccgtttgcga ccgtgaaggt gaacacctcc    840

aaggacgtcg tcatcgacga cgtcaacatc cgcaacccgt ggtacgggca gaacacggac    900

ggaatcgacg tgtcggccga tgagaatgtc gtcttgtatc gcgacgtgat cgacacgggc    960

gacgacggca tcgcattgga gtcgagcggg aacgacgcgg cgggggtgtt caacgagcag   1020

gacgtcgtcg tggcggactg catcgtgcac aacggccaca gcggtttcgc cgtcggcagt   1080

tacacagacg gcggcatccg ggacgtgtgg gtgacgggtg acgtgtacga cggcacggag   1140

tcgggcctgc gcttcaagag cggcgtgggc aagggcggac tggtggagga catcgacatg   1200

gaccacatcg tcatgcggga catcagtgga gccgccatca ccttcgacga cgggtacgtg   1260

gacaacggag cggacacatc atcgcttcaa gcgcccgggc caaactcgta cgtgccgcag   1320

tttgagaaca tgaccatctc gaacgtgagt tgcgagtacg cgggccagtc catctacatg   1380

aacggcctgc cgaacgcccc tatctcgaac atcatgctgg acgacgtcaa catcacggcc   1440

aataagccgc cgcagattca gaacacctcg aaccttgtgg agaatcaggt gcagatccag   1500

tcgggcgtga ccatgctcgg cgagattccg cactga                             1536


<210>  178
<211>  1536
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 167

<400>  178
gtgacatgcg tgcacaggtg gaaacgtggt gtgtcggcag gcgcaagcct cgcgctggtc     60

gcggcagccg ccaccggttg gaccgttcac gcgcgcttcg cgcacgccga caacgtggtc    120

gatctcgtcg cgcagacggg cgatctcgac gcttctctcg cccaggtcct gcacggcgcg    180

ccgtttgcca tgcccatccc gtcgttgccg gacatcgtgc cccgcgtcta cgacatcacc    240

gagtacggcg cgaagccggg catcggccag gtgaacacac aggccattca ggcggccatc    300

gacgcggcaa gccaacacgg cggtggcatc gtcgacattc cgccggggta ttgggtcacc    360

ggtcccatcg tgctcaagag ccacgtcgat ctgaacgtgg agtccggcgc ccaactccag    420

ttttcgggcg atcacgacct gtatccgctc gttccgagcg ggaattccta catcgttcaa    480

tcgcccatca gcgcgacaaa cgcggtggat gtcgccatca cgggtcacgg cgtcatcgac    540

ggcgccggca atacgtggcg gcccgtggag aagtcgaagc tttcggcgga tcagtggaat    600

gcgctcgtgg cgtcgggtgg cgtggtgtcg ccggacggca gcacctggtg gccgacggcg    660

cagggtgcga acgcccaggc gtatatcaag gcgcatccga acatgacgta tcaggacgac    720

ttgcaggtga aggactacct gcggccgtac atggtgtact tccagggatg tcaacgcgtg    780

tggctccagg gcgtgacgtt tgaaaattcg ccgtttgcga ccgtgaaggt gaacacctcc    840

aaggacgtcg tcatcgacga cgtcaacatc cgcaacccgt ggtacgggca gaacacggac    900

ggaatcgacg tgtcggccga tgagaatgtc gtcttgtatc gcgacgtgat cgacacgggc    960

gacgacggca tcgcattgga gtcgagcggg aacgacgcgg cgggggtgtt caacgagcag   1020

gacgtcgtcg tggcggactg catcgtgcac aacggccaca gcggtttcgc cgtcggcagt   1080

tacacagacg gcggcatccg ggacgtgtgg gtgacgggtg acgtgtacga cggcacggag   1140

tcgggcctgc gcttcaagag cggcgtgggc aagggcggac tggtggagga catcgacatg   1200

gaccacatcg tcatgcggga catcagtgga gccgccatca ccttcgacga cgggtacgtg   1260

gacaacggag cggacacatc atcgcttcaa gcgcccgggc caaactcgta cgtgccgcag   1320

tttgagaaca tgaccatctc gaacgtgagt tgcgagtacg cgggccagtc catctacatg   1380

aacggcctgc cgaacgcccc tatctcgaac atcatgctgg acgacgtcaa catcacggcc   1440

aataagccgc cgcagattca gaacacctcg aaccttgtgg agaatcaggt gcagatccag   1500

tcgggcgtga ccatgctcgg cgagattccg cactga                             1536


<210>  179
<211>  511
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:168 and encoded by SEQ ID NO:174

<400>  179

Met Thr Cys Val His Lys Trp Lys Arg Gly Leu Ser Ala Gly Ala Ser 
1               5                   10                  15      


Leu Ala Leu Val Ala Ala Ala Ala Thr Gly Trp Thr Val His Ala Arg 
            20                  25                  30          


Phe Ala His Ala Asp Asn Val Val Asp Leu Val Ala Gln Thr Gly Asp 
        35                  40                  45              


Leu Asp Ala Ser Leu Ala Gln Val Leu His Gly Ala Pro Phe Ala Met 
    50                  55                  60                  


Pro Ile Pro Ser Leu Pro Asp Ile Val Pro Arg Val Tyr Asp Ile Thr 
65                  70                  75                  80  


Glu Tyr Gly Ala Lys Pro Gly Ile Gly Gln Val Asn Thr Gln Ala Ile 
                85                  90                  95      


Gln Ala Ala Ile Asp Ala Ala Ser Gln His Gly Gly Gly Ile Val Asp 
            100                 105                 110         


Ile Pro Pro Gly Tyr Trp Val Thr Gly Pro Ile Val Leu Lys Ser His 
        115                 120                 125             


Val Asp Leu Asn Val Glu Ser Gly Ala Gln Leu Gln Phe Ser Gly Asp 
    130                 135                 140                 


His Asp Leu Tyr Pro Leu Val Pro Ser Gly Asn Ser Tyr Ile Val Gln 
145                 150                 155                 160 


Ser Pro Ile Ser Ala Thr Asn Ala Val Asp Val Ala Ile Thr Gly His 
                165                 170                 175     


Gly Val Ile Asp Gly Ala Gly Asn Thr Trp Arg Pro Val Glu Lys Ser 
            180                 185                 190         


Lys Leu Ser Ala Asp Gln Trp Asn Ala Leu Val Ala Ser Gly Gly Val 
        195                 200                 205             


Val Ser Pro Asp Gly Ser Thr Trp Trp Pro Thr Ala Gln Gly Ala Asn 
    210                 215                 220                 


Ala Gln Ala Tyr Ile Lys Ala His Pro Asn Met Thr Tyr Gln Asp Asp 
225                 230                 235                 240 


Leu Gln Val Lys Asp Tyr Leu Arg Pro Tyr Met Val Tyr Phe Gln Gly 
                245                 250                 255     


Cys Gln Arg Val Trp Leu Gln Gly Val Thr Phe Glu Asn Ser Pro Phe 
            260                 265                 270         


Ala Thr Val Lys Val Asn Thr Ser Lys Asp Val Val Ile Asp Asp Val 
        275                 280                 285             


Asn Ile Arg Asn Pro Trp Tyr Gly Gln Asn Thr Asp Gly Ile Asp Val 
    290                 295                 300                 


Ser Ala Asp Glu Asn Val Val Leu Tyr Arg Asp Val Ile Asp Thr Gly 
305                 310                 315                 320 


Asp Asp Gly Ile Ala Leu Glu Ser Ser Gly Asn Asp Ala Ala Gly Val 
                325                 330                 335     


Phe Asn Glu Gln Asp Val Val Val Ala Asp Cys Ile Val His Asn Gly 
            340                 345                 350         


His Ser Gly Phe Ala Val Gly Ser Tyr Thr Asp Gly Gly Ile Arg Asp 
        355                 360                 365             


Val Trp Val Thr Gly Asp Val Tyr Asp Gly Thr Glu Ser Gly Leu Arg 
    370                 375                 380                 


Phe Lys Ser Gly Val Gly Lys Gly Gly Leu Val Glu Asp Ile Asp Met 
385                 390                 395                 400 


Asp His Ile Val Met Arg Asp Ile Ser Gly Ala Ala Ile Thr Phe Asp 
                405                 410                 415     


Asp Gly Tyr Val Asp Asn Gly Ala Asp Thr Ser Ser Leu Gln Ala Pro 
            420                 425                 430         


Gly Pro Asn Ser Tyr Val Pro Gln Phe Glu Asn Met Thr Ile Ser Asn 
        435                 440                 445             


Val Ser Cys Glu Tyr Ala Gly Gln Ser Ile Tyr Met Asn Gly Leu Pro 
    450                 455                 460                 


Asn Ala Pro Ile Ser Asn Ile Met Leu Asp Asp Val Asn Ile Thr Ala 
465                 470                 475                 480 


Asn Lys Pro Pro Gln Ile Gln Asn Thr Ser Asn Leu Val Glu Asn Gln 
                485                 490                 495     


Val Gln Ile Gln Ser Gly Val Thr Met Leu Gly Glu Ile Pro His 
            500                 505                 510     


<210>  180
<211>  511
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:168 and encoded by SEQ ID NO:175

<400>  180

Met Thr Cys Val His Arg Trp Arg Arg Gly Leu Ser Ala Gly Ala Ser 
1               5                   10                  15      


Leu Ala Leu Val Ala Ala Ala Ala Thr Gly Trp Thr Val His Ala Arg 
            20                  25                  30          


Phe Ala His Ala Asp Asn Val Val Asp Leu Val Ala Gln Thr Gly Asp 
        35                  40                  45              


Leu Asp Ala Ser Leu Ala Gln Val Leu His Gly Ala Pro Phe Ala Met 
    50                  55                  60                  


Pro Ile Pro Ser Leu Pro Asp Ile Val Pro Arg Val Tyr Asp Ile Thr 
65                  70                  75                  80  


Glu Tyr Gly Ala Lys Pro Gly Ile Gly Gln Val Asn Thr Gln Ala Ile 
                85                  90                  95      


Gln Ala Ala Ile Asp Ala Ala Ser Gln His Gly Gly Gly Ile Val Asp 
            100                 105                 110         


Ile Pro Pro Gly Tyr Trp Val Thr Gly Pro Ile Val Leu Lys Ser His 
        115                 120                 125             


Val Asp Leu Asn Val Glu Ser Gly Ala Gln Leu Gln Phe Ser Gly Asp 
    130                 135                 140                 


His Asp Leu Tyr Pro Leu Val Pro Ser Gly Asn Ser Tyr Ile Val Gln 
145                 150                 155                 160 


Ser Pro Ile Ser Ala Thr Asn Ala Val Asp Val Ala Ile Thr Gly His 
                165                 170                 175     


Gly Val Ile Asp Gly Ala Gly Asn Thr Trp Arg Pro Val Glu Lys Ser 
            180                 185                 190         


Lys Leu Ser Ala Asp Gln Trp Asn Ala Leu Val Ala Ser Gly Gly Val 
        195                 200                 205             


Val Ser Pro Asp Gly Ser Thr Trp Trp Pro Thr Ala Gln Gly Ala Asn 
    210                 215                 220                 


Ala Gln Ala Tyr Ile Lys Ala His Pro Asn Met Thr Tyr Gln Asp Asp 
225                 230                 235                 240 


Leu Gln Val Lys Asp Tyr Leu Arg Pro Tyr Met Val Tyr Phe Gln Gly 
                245                 250                 255     


Cys Gln Arg Val Trp Leu Gln Gly Val Thr Phe Glu Asn Ser Pro Phe 
            260                 265                 270         


Ala Thr Val Lys Val Asn Thr Ser Lys Asp Val Val Ile Asp Asp Val 
        275                 280                 285             


Asn Ile Arg Asn Pro Trp Tyr Gly Gln Asn Thr Asp Gly Ile Asp Val 
    290                 295                 300                 


Ser Ala Asp Glu Asn Val Val Leu Tyr Arg Asp Val Ile Asp Thr Gly 
305                 310                 315                 320 


Asp Asp Gly Ile Ala Leu Glu Ser Ser Gly Asn Asp Ala Ala Gly Val 
                325                 330                 335     


Phe Asn Glu Gln Asp Val Val Val Ala Asp Cys Ile Val His Asn Gly 
            340                 345                 350         


His Ser Gly Phe Ala Val Gly Ser Tyr Thr Asp Gly Gly Ile Arg Asp 
        355                 360                 365             


Val Trp Val Thr Gly Asp Val Tyr Asp Gly Thr Glu Ser Gly Leu Arg 
    370                 375                 380                 


Phe Lys Ser Gly Val Gly Lys Gly Gly Leu Val Glu Asp Ile Asp Met 
385                 390                 395                 400 


Asp His Ile Val Met Arg Asp Ile Ser Gly Ala Ala Ile Thr Phe Asp 
                405                 410                 415     


Asp Gly Tyr Val Asp Asn Gly Ala Asp Thr Ser Ser Leu Gln Ala Pro 
            420                 425                 430         


Gly Pro Asn Ser Tyr Val Pro Gln Phe Glu Asn Met Thr Ile Ser Asn 
        435                 440                 445             


Val Ser Cys Glu Tyr Ala Gly Gln Ser Ile Tyr Met Asn Gly Leu Pro 
    450                 455                 460                 


Asn Ala Pro Ile Ser Asn Ile Met Leu Asp Asp Val Asn Ile Thr Ala 
465                 470                 475                 480 


Asn Lys Pro Pro Gln Ile Gln Asn Thr Ser Asn Leu Val Glu Asn Gln 
                485                 490                 495     


Val Gln Ile Gln Ser Gly Val Thr Met Leu Gly Glu Ile Pro His 
            500                 505                 510     


<210>  181
<211>  511
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:168 and encoded by SEQ ID NO:176

<400>  181

Met Thr Cys Val His Arg Trp Lys Lys Gly Leu Ser Ala Gly Ala Ser 
1               5                   10                  15      


Leu Ala Leu Val Ala Ala Ala Ala Thr Gly Trp Thr Val His Ala Arg 
            20                  25                  30          


Phe Ala His Ala Asp Asn Val Val Asp Leu Val Ala Gln Thr Gly Asp 
        35                  40                  45              


Leu Asp Ala Ser Leu Ala Gln Val Leu His Gly Ala Pro Phe Ala Met 
    50                  55                  60                  


Pro Ile Pro Ser Leu Pro Asp Ile Val Pro Arg Val Tyr Asp Ile Thr 
65                  70                  75                  80  


Glu Tyr Gly Ala Lys Pro Gly Ile Gly Gln Val Asn Thr Gln Ala Ile 
                85                  90                  95      


Gln Ala Ala Ile Asp Ala Ala Ser Gln His Gly Gly Gly Ile Val Asp 
            100                 105                 110         


Ile Pro Pro Gly Tyr Trp Val Thr Gly Pro Ile Val Leu Lys Ser His 
        115                 120                 125             


Val Asp Leu Asn Val Glu Ser Gly Ala Gln Leu Gln Phe Ser Gly Asp 
    130                 135                 140                 


His Asp Leu Tyr Pro Leu Val Pro Ser Gly Asn Ser Tyr Ile Val Gln 
145                 150                 155                 160 


Ser Pro Ile Ser Ala Thr Asn Ala Val Asp Val Ala Ile Thr Gly His 
                165                 170                 175     


Gly Val Ile Asp Gly Ala Gly Asn Thr Trp Arg Pro Val Glu Lys Ser 
            180                 185                 190         


Lys Leu Ser Ala Asp Gln Trp Asn Ala Leu Val Ala Ser Gly Gly Val 
        195                 200                 205             


Val Ser Pro Asp Gly Ser Thr Trp Trp Pro Thr Ala Gln Gly Ala Asn 
    210                 215                 220                 


Ala Gln Ala Tyr Ile Lys Ala His Pro Asn Met Thr Tyr Gln Asp Asp 
225                 230                 235                 240 


Leu Gln Val Lys Asp Tyr Leu Arg Pro Tyr Met Val Tyr Phe Gln Gly 
                245                 250                 255     


Cys Gln Arg Val Trp Leu Gln Gly Val Thr Phe Glu Asn Ser Pro Phe 
            260                 265                 270         


Ala Thr Val Lys Val Asn Thr Ser Lys Asp Val Val Ile Asp Asp Val 
        275                 280                 285             


Asn Ile Arg Asn Pro Trp Tyr Gly Gln Asn Thr Asp Gly Ile Asp Val 
    290                 295                 300                 


Ser Ala Asp Glu Asn Val Val Leu Tyr Arg Asp Val Ile Asp Thr Gly 
305                 310                 315                 320 


Asp Asp Gly Ile Ala Leu Glu Ser Ser Gly Asn Asp Ala Ala Gly Val 
                325                 330                 335     


Phe Asn Glu Gln Asp Val Val Val Ala Asp Cys Ile Val His Asn Gly 
            340                 345                 350         


His Ser Gly Phe Ala Val Gly Ser Tyr Thr Asp Gly Gly Ile Arg Asp 
        355                 360                 365             


Val Trp Val Thr Gly Asp Val Tyr Asp Gly Thr Glu Ser Gly Leu Arg 
    370                 375                 380                 


Phe Lys Ser Gly Val Gly Lys Gly Gly Leu Val Glu Asp Ile Asp Met 
385                 390                 395                 400 


Asp His Ile Val Met Arg Asp Ile Ser Gly Ala Ala Ile Thr Phe Asp 
                405                 410                 415     


Asp Gly Tyr Val Asp Asn Gly Ala Asp Thr Ser Ser Leu Gln Ala Pro 
            420                 425                 430         


Gly Pro Asn Ser Tyr Val Pro Gln Phe Glu Asn Met Thr Ile Ser Asn 
        435                 440                 445             


Val Ser Cys Glu Tyr Ala Gly Gln Ser Ile Tyr Met Asn Gly Leu Pro 
    450                 455                 460                 


Asn Ala Pro Ile Ser Asn Ile Met Leu Asp Asp Val Asn Ile Thr Ala 
465                 470                 475                 480 


Asn Lys Pro Pro Gln Ile Gln Asn Thr Ser Asn Leu Val Glu Asn Gln 
                485                 490                 495     


Val Gln Ile Gln Ser Gly Val Thr Met Leu Gly Glu Ile Pro His 
            500                 505                 510     


<210>  182
<211>  511
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:168 and encoded by SEQ ID NO:177

<400>  182

Met Thr Cys Val His Arg Trp Lys Arg Gly Ile Ser Ala Gly Ala Ser 
1               5                   10                  15      


Leu Ala Leu Val Ala Ala Ala Ala Thr Gly Trp Thr Val His Ala Arg 
            20                  25                  30          


Phe Ala His Ala Asp Asn Val Val Asp Leu Val Ala Gln Thr Gly Asp 
        35                  40                  45              


Leu Asp Ala Ser Leu Ala Gln Val Leu His Gly Ala Pro Phe Ala Met 
    50                  55                  60                  


Pro Ile Pro Ser Leu Pro Asp Ile Val Pro Arg Val Tyr Asp Ile Thr 
65                  70                  75                  80  


Glu Tyr Gly Ala Lys Pro Gly Ile Gly Gln Val Asn Thr Gln Ala Ile 
                85                  90                  95      


Gln Ala Ala Ile Asp Ala Ala Ser Gln His Gly Gly Gly Ile Val Asp 
            100                 105                 110         


Ile Pro Pro Gly Tyr Trp Val Thr Gly Pro Ile Val Leu Lys Ser His 
        115                 120                 125             


Val Asp Leu Asn Val Glu Ser Gly Ala Gln Leu Gln Phe Ser Gly Asp 
    130                 135                 140                 


His Asp Leu Tyr Pro Leu Val Pro Ser Gly Asn Ser Tyr Ile Val Gln 
145                 150                 155                 160 


Ser Pro Ile Ser Ala Thr Asn Ala Val Asp Val Ala Ile Thr Gly His 
                165                 170                 175     


Gly Val Ile Asp Gly Ala Gly Asn Thr Trp Arg Pro Val Glu Lys Ser 
            180                 185                 190         


Lys Leu Ser Ala Asp Gln Trp Asn Ala Leu Val Ala Ser Gly Gly Val 
        195                 200                 205             


Val Ser Pro Asp Gly Ser Thr Trp Trp Pro Thr Ala Gln Gly Ala Asn 
    210                 215                 220                 


Ala Gln Ala Tyr Ile Lys Ala His Pro Asn Met Thr Tyr Gln Asp Asp 
225                 230                 235                 240 


Leu Gln Val Lys Asp Tyr Leu Arg Pro Tyr Met Val Tyr Phe Gln Gly 
                245                 250                 255     


Cys Gln Arg Val Trp Leu Gln Gly Val Thr Phe Glu Asn Ser Pro Phe 
            260                 265                 270         


Ala Thr Val Lys Val Asn Thr Ser Lys Asp Val Val Ile Asp Asp Val 
        275                 280                 285             


Asn Ile Arg Asn Pro Trp Tyr Gly Gln Asn Thr Asp Gly Ile Asp Val 
    290                 295                 300                 


Ser Ala Asp Glu Asn Val Val Leu Tyr Arg Asp Val Ile Asp Thr Gly 
305                 310                 315                 320 


Asp Asp Gly Ile Ala Leu Glu Ser Ser Gly Asn Asp Ala Ala Gly Val 
                325                 330                 335     


Phe Asn Glu Gln Asp Val Val Val Ala Asp Cys Ile Val His Asn Gly 
            340                 345                 350         


His Ser Gly Phe Ala Val Gly Ser Tyr Thr Asp Gly Gly Ile Arg Asp 
        355                 360                 365             


Val Trp Val Thr Gly Asp Val Tyr Asp Gly Thr Glu Ser Gly Leu Arg 
    370                 375                 380                 


Phe Lys Ser Gly Val Gly Lys Gly Gly Leu Val Glu Asp Ile Asp Met 
385                 390                 395                 400 


Asp His Ile Val Met Arg Asp Ile Ser Gly Ala Ala Ile Thr Phe Asp 
                405                 410                 415     


Asp Gly Tyr Val Asp Asn Gly Ala Asp Thr Ser Ser Leu Gln Ala Pro 
            420                 425                 430         


Gly Pro Asn Ser Tyr Val Pro Gln Phe Glu Asn Met Thr Ile Ser Asn 
        435                 440                 445             


Val Ser Cys Glu Tyr Ala Gly Gln Ser Ile Tyr Met Asn Gly Leu Pro 
    450                 455                 460                 


Asn Ala Pro Ile Ser Asn Ile Met Leu Asp Asp Val Asn Ile Thr Ala 
465                 470                 475                 480 


Asn Lys Pro Pro Gln Ile Gln Asn Thr Ser Asn Leu Val Glu Asn Gln 
                485                 490                 495     


Val Gln Ile Gln Ser Gly Val Thr Met Leu Gly Glu Ile Pro His 
            500                 505                 510     


<210>  183
<211>  511
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:168 and encoded by SEQ ID NO:178

<400>  183

Met Thr Cys Val His Arg Trp Lys Arg Gly Val Ser Ala Gly Ala Ser 
1               5                   10                  15      


Leu Ala Leu Val Ala Ala Ala Ala Thr Gly Trp Thr Val His Ala Arg 
            20                  25                  30          


Phe Ala His Ala Asp Asn Val Val Asp Leu Val Ala Gln Thr Gly Asp 
        35                  40                  45              


Leu Asp Ala Ser Leu Ala Gln Val Leu His Gly Ala Pro Phe Ala Met 
    50                  55                  60                  


Pro Ile Pro Ser Leu Pro Asp Ile Val Pro Arg Val Tyr Asp Ile Thr 
65                  70                  75                  80  


Glu Tyr Gly Ala Lys Pro Gly Ile Gly Gln Val Asn Thr Gln Ala Ile 
                85                  90                  95      


Gln Ala Ala Ile Asp Ala Ala Ser Gln His Gly Gly Gly Ile Val Asp 
            100                 105                 110         


Ile Pro Pro Gly Tyr Trp Val Thr Gly Pro Ile Val Leu Lys Ser His 
        115                 120                 125             


Val Asp Leu Asn Val Glu Ser Gly Ala Gln Leu Gln Phe Ser Gly Asp 
    130                 135                 140                 


His Asp Leu Tyr Pro Leu Val Pro Ser Gly Asn Ser Tyr Ile Val Gln 
145                 150                 155                 160 


Ser Pro Ile Ser Ala Thr Asn Ala Val Asp Val Ala Ile Thr Gly His 
                165                 170                 175     


Gly Val Ile Asp Gly Ala Gly Asn Thr Trp Arg Pro Val Glu Lys Ser 
            180                 185                 190         


Lys Leu Ser Ala Asp Gln Trp Asn Ala Leu Val Ala Ser Gly Gly Val 
        195                 200                 205             


Val Ser Pro Asp Gly Ser Thr Trp Trp Pro Thr Ala Gln Gly Ala Asn 
    210                 215                 220                 


Ala Gln Ala Tyr Ile Lys Ala His Pro Asn Met Thr Tyr Gln Asp Asp 
225                 230                 235                 240 


Leu Gln Val Lys Asp Tyr Leu Arg Pro Tyr Met Val Tyr Phe Gln Gly 
                245                 250                 255     


Cys Gln Arg Val Trp Leu Gln Gly Val Thr Phe Glu Asn Ser Pro Phe 
            260                 265                 270         


Ala Thr Val Lys Val Asn Thr Ser Lys Asp Val Val Ile Asp Asp Val 
        275                 280                 285             


Asn Ile Arg Asn Pro Trp Tyr Gly Gln Asn Thr Asp Gly Ile Asp Val 
    290                 295                 300                 


Ser Ala Asp Glu Asn Val Val Leu Tyr Arg Asp Val Ile Asp Thr Gly 
305                 310                 315                 320 


Asp Asp Gly Ile Ala Leu Glu Ser Ser Gly Asn Asp Ala Ala Gly Val 
                325                 330                 335     


Phe Asn Glu Gln Asp Val Val Val Ala Asp Cys Ile Val His Asn Gly 
            340                 345                 350         


His Ser Gly Phe Ala Val Gly Ser Tyr Thr Asp Gly Gly Ile Arg Asp 
        355                 360                 365             


Val Trp Val Thr Gly Asp Val Tyr Asp Gly Thr Glu Ser Gly Leu Arg 
    370                 375                 380                 


Phe Lys Ser Gly Val Gly Lys Gly Gly Leu Val Glu Asp Ile Asp Met 
385                 390                 395                 400 


Asp His Ile Val Met Arg Asp Ile Ser Gly Ala Ala Ile Thr Phe Asp 
                405                 410                 415     


Asp Gly Tyr Val Asp Asn Gly Ala Asp Thr Ser Ser Leu Gln Ala Pro 
            420                 425                 430         


Gly Pro Asn Ser Tyr Val Pro Gln Phe Glu Asn Met Thr Ile Ser Asn 
        435                 440                 445             


Val Ser Cys Glu Tyr Ala Gly Gln Ser Ile Tyr Met Asn Gly Leu Pro 
    450                 455                 460                 


Asn Ala Pro Ile Ser Asn Ile Met Leu Asp Asp Val Asn Ile Thr Ala 
465                 470                 475                 480 


Asn Lys Pro Pro Gln Ile Gln Asn Thr Ser Asn Leu Val Glu Asn Gln 
                485                 490                 495     


Val Gln Ile Gln Ser Gly Val Thr Met Leu Gly Glu Ile Pro His 
            500                 505                 510     


<210>  184
<211>  2232
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  184
gtggcgattg ggaaaggacg accttcgatg cccatcatct ttcactcgga tgagcgcctg     60

tttcacctga tgacgccgag atcgagctac gtgtttcgcg tcggccatga cggcttattg    120

gaacacgtct actggggcgc caggttggaa gacgcgtcgg acctggtccg cctggcgcgc    180

gcttgccagc ggctcgatgc gcggccggag cacatgcgcg ccatcgacat cggctcgctt    240

cgcctcgagt acccctcatt cgggacgggc gaccaccgcg atcctgccta cgaggtcttg    300

cagccttcgg gcagccacgc gtcccagctc gtgtacgaat cccaccagat ccgacctggc    360

aagccgccgc ttccgggcct gcctgcgttt tacgtcgaat ccgatttcga agcggacacg    420

ctcgagattt cgctggtcga tccggccatc tcgctgcgcg tgatcctctc ctacaccgcc    480

taccgcgact tcgatctcgt ctgccgccac gcgcgcttgg agaatgcggg taccgaaccg    540

ctcgtcctgc gccgggcgct ctccgcatct gtcgatctcg acctgcggga ggcggacttc    600

gtccaactct ccggcgcctg gatccgcgag cggttcatcc aacggacgcc gctttcgcct    660

gggcggcatg agatcatgag ccgctccggc gcgagcggtc acaagcacaa cccgttcttc    720

gccctcgcgg cgccgcatac gacggaggaa ggcggcgagg tgcgcgcgtt cgctctcgtg    780

tacagcggca attttctcgg cgcctgcgag atggagccca tgcggcaaaa cgtgcgcgcg    840

cagatcggca tccacccttc cgatttctcc tggcgcctcg aacccggcga gcggtttgtc    900

acgcccgagg cggcgctcgt ctactcggac gagggatggg gcggtatgtc gcgcacgttc    960

caccgcgcca ttcgaaagag gctgtgccga gggacctatc gcgatcgcgt ccgccccgtg   1020

ctcatcaaca attgggaagc gacgtacttc catttcgacg aggaagatct cgtcgagatc   1080

gcagagcaag cccgcgatct cggcgcggag atgttcgtcc tcgacgacgg ctggttcggc   1140

cagcgcgacg acgatcacac gtcgctcggc gactggtggc cgcacccgcg caaactgccg   1200

aacgggctgc gccatctcgc cgatcgcatc cacgcgctcg ggcttcgctt cggcatctgg   1260

atggagccgg agatggtgtc gccgaagagc gagctgtatc gtgagcatcc ggattggtgc   1320

ctgcacgtgg cggatcggcc gagatcggag cgaaggcatc agctgatgct cgacctcacg   1380

cgcgaggatg tgcgcgcctt cgtggtgaac gcggtgtcgc gcgtgatcga agaaggggcc   1440

gtcgattaca tcaagtggga catgaatcgg ccgatgaccg aggtcggatc ggccgcgctt   1500

ccgcctgagc gccagcgcga ggtcgcgcac cgctacgtgc tcgggctgta cgagatcctg   1560

gagacgctca cgagccgatt cccgaacgtg ctatttgaaa actgcgcctc gggcgggggc   1620

aggttcgaac tcggcatgct ccactacatg ccgcagacgt ggacgagcga caacacggac   1680

gccgtctccc ggctgaagat ccagcacggc acgagcctcg tctatccgcc agtcgcgatg   1740

ggcgcgcacg tgtcggccgt tccaaaccac cagatggggc gcgtcacgcc gttcgccctc   1800

cgcgccggcg tcgccatgtg cggcaacttc ggcttcgagc tcgatccgcg gcgcctttcg   1860

gacgcggagc ggcgcgaggc gcgtcaggcg gtggagcggt acaaagcgct tcgacacctc   1920

gtgcagttcg gcgacttcta ccggctgctg tccccgtttg acgggcccga ggcggcctgg   1980

atgttcgctg tcgaggatgg cagcgaggcg ctcgtcgcct atttctgcac gtatccggat   2040

cccttggatc cgccggcgcg cgtggtcctg cgcggcctgc ggcccgaggc gcgctatagg   2100

tgtgaggcgc tcggcgagag cttccgcggc gacgcactga tgcgccacgg cctcgtcatt   2160

ccgcgccagg tgggcgacgg gcaggccgtg ctcattcatc tcaagcaaat cggggaaggt   2220

gatcgcccgt ga                                                       2232


<210>  185
<211>  743
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  185

Met Ala Ile Gly Lys Gly Arg Pro Ser Met Pro Ile Ile Phe His Ser 
1               5                   10                  15      


Asp Glu Arg Leu Phe His Leu Met Thr Pro Arg Ser Ser Tyr Val Phe 
            20                  25                  30          


Arg Val Gly His Asp Gly Leu Leu Glu His Val Tyr Trp Gly Ala Arg 
        35                  40                  45              


Leu Glu Asp Ala Ser Asp Leu Val Arg Leu Ala Arg Ala Cys Gln Arg 
    50                  55                  60                  


Leu Asp Ala Arg Pro Glu His Met Arg Ala Ile Asp Ile Gly Ser Leu 
65                  70                  75                  80  


Arg Leu Glu Tyr Pro Ser Phe Gly Thr Gly Asp His Arg Asp Pro Ala 
                85                  90                  95      


Tyr Glu Val Leu Gln Pro Ser Gly Ser His Ala Ser Gln Leu Val Tyr 
            100                 105                 110         


Glu Ser His Gln Ile Arg Pro Gly Lys Pro Pro Leu Pro Gly Leu Pro 
        115                 120                 125             


Ala Phe Tyr Val Glu Ser Asp Phe Glu Ala Asp Thr Leu Glu Ile Ser 
    130                 135                 140                 


Leu Val Asp Pro Ala Ile Ser Leu Arg Val Ile Leu Ser Tyr Thr Ala 
145                 150                 155                 160 


Tyr Arg Asp Phe Asp Leu Val Cys Arg His Ala Arg Leu Glu Asn Ala 
                165                 170                 175     


Gly Thr Glu Pro Leu Val Leu Arg Arg Ala Leu Ser Ala Ser Val Asp 
            180                 185                 190         


Leu Asp Leu Arg Glu Ala Asp Phe Val Gln Leu Ser Gly Ala Trp Ile 
        195                 200                 205             


Arg Glu Arg Phe Ile Gln Arg Thr Pro Leu Ser Pro Gly Arg His Glu 
    210                 215                 220                 


Ile Met Ser Arg Ser Gly Ala Ser Gly His Lys His Asn Pro Phe Phe 
225                 230                 235                 240 


Ala Leu Ala Ala Pro His Thr Thr Glu Glu Gly Gly Glu Val Arg Ala 
                245                 250                 255     


Phe Ala Leu Val Tyr Ser Gly Asn Phe Leu Gly Ala Cys Glu Met Glu 
            260                 265                 270         


Pro Met Arg Gln Asn Val Arg Ala Gln Ile Gly Ile His Pro Ser Asp 
        275                 280                 285             


Phe Ser Trp Arg Leu Glu Pro Gly Glu Arg Phe Val Thr Pro Glu Ala 
    290                 295                 300                 


Ala Leu Val Tyr Ser Asp Glu Gly Trp Gly Gly Met Ser Arg Thr Phe 
305                 310                 315                 320 


His Arg Ala Ile Arg Lys Arg Leu Cys Arg Gly Thr Tyr Arg Asp Arg 
                325                 330                 335     


Val Arg Pro Val Leu Ile Asn Asn Trp Glu Ala Thr Tyr Phe His Phe 
            340                 345                 350         


Asp Glu Glu Asp Leu Val Glu Ile Ala Glu Gln Ala Arg Asp Leu Gly 
        355                 360                 365             


Ala Glu Met Phe Val Leu Asp Asp Gly Trp Phe Gly Gln Arg Asp Asp 
    370                 375                 380                 


Asp His Thr Ser Leu Gly Asp Trp Trp Pro His Pro Arg Lys Leu Pro 
385                 390                 395                 400 


Asn Gly Leu Arg His Leu Ala Asp Arg Ile His Ala Leu Gly Leu Arg 
                405                 410                 415     


Phe Gly Ile Trp Met Glu Pro Glu Met Val Ser Pro Lys Ser Glu Leu 
            420                 425                 430         


Tyr Arg Glu His Pro Asp Trp Cys Leu His Val Ala Asp Arg Pro Arg 
        435                 440                 445             


Ser Glu Arg Arg His Gln Leu Met Leu Asp Leu Thr Arg Glu Asp Val 
    450                 455                 460                 


Arg Ala Phe Val Val Asn Ala Val Ser Arg Val Ile Glu Glu Gly Ala 
465                 470                 475                 480 


Val Asp Tyr Ile Lys Trp Asp Met Asn Arg Pro Met Thr Glu Val Gly 
                485                 490                 495     


Ser Ala Ala Leu Pro Pro Glu Arg Gln Arg Glu Val Ala His Arg Tyr 
            500                 505                 510         


Val Leu Gly Leu Tyr Glu Ile Leu Glu Thr Leu Thr Ser Arg Phe Pro 
        515                 520                 525             


Asn Val Leu Phe Glu Asn Cys Ala Ser Gly Gly Gly Arg Phe Glu Leu 
    530                 535                 540                 


Gly Met Leu His Tyr Met Pro Gln Thr Trp Thr Ser Asp Asn Thr Asp 
545                 550                 555                 560 


Ala Val Ser Arg Leu Lys Ile Gln His Gly Thr Ser Leu Val Tyr Pro 
                565                 570                 575     


Pro Val Ala Met Gly Ala His Val Ser Ala Val Pro Asn His Gln Met 
            580                 585                 590         


Gly Arg Val Thr Pro Phe Ala Leu Arg Ala Gly Val Ala Met Cys Gly 
        595                 600                 605             


Asn Phe Gly Phe Glu Leu Asp Pro Arg Arg Leu Ser Asp Ala Glu Arg 
    610                 615                 620                 


Arg Glu Ala Arg Gln Ala Val Glu Arg Tyr Lys Ala Leu Arg His Leu 
625                 630                 635                 640 


Val Gln Phe Gly Asp Phe Tyr Arg Leu Leu Ser Pro Phe Asp Gly Pro 
                645                 650                 655     


Glu Ala Ala Trp Met Phe Ala Val Glu Asp Gly Ser Glu Ala Leu Val 
            660                 665                 670         


Ala Tyr Phe Cys Thr Tyr Pro Asp Pro Leu Asp Pro Pro Ala Arg Val 
        675                 680                 685             


Val Leu Arg Gly Leu Arg Pro Glu Ala Arg Tyr Arg Cys Glu Ala Leu 
    690                 695                 700                 


Gly Glu Ser Phe Arg Gly Asp Ala Leu Met Arg His Gly Leu Val Ile 
705                 710                 715                 720 


Pro Arg Gln Val Gly Asp Gly Gln Ala Val Leu Ile His Leu Lys Gln 
                725                 730                 735     


Ile Gly Glu Gly Asp Arg Pro 
            740             


<210>  186
<211>  748
<212>  PRT
<213>  Bacillus halodurans

<400>  186

Met Pro Ile Phe Tyr Thr Glu Gln Thr Lys Glu Phe His Leu Gln Thr 
1               5                   10                  15      


Lys Gly Ser Ser Tyr Ile Phe Thr Val Leu Asp Asn Gln Gln Leu Gly 
            20                  25                  30          


His Leu Tyr Tyr Gly Lys Lys Ile Glu His Arg Asp Ser Phe Thr His 
        35                  40                  45              


Leu Leu Arg Phe Gln Arg Arg Ala Thr Ser Ser Cys Val Phe Glu Gly 
    50                  55                  60                  


Asn Leu Glu Phe Ser Leu Asp Leu Ile Lys Gln Glu Phe Pro Ser Tyr 
65                  70                  75                  80  


Gly Thr Thr Asp Tyr Arg Glu Pro Ala Phe Gln Ile Leu Gln Glu Asn 
                85                  90                  95      


Gly Ser Arg Ile Thr Asn Phe Glu Tyr Lys Asn His Val Ile Ser Ser 
            100                 105                 110         


Gly Lys Lys Pro Leu Lys Gly Leu Pro Ala Thr Tyr Val Glu Ser Glu 
        115                 120                 125             


Glu Glu Ala Ala Thr Leu Glu Val Phe Leu Tyr Asp Ser Leu Ile Asp 
    130                 135                 140                 


Val Glu Leu Val Leu Thr Tyr Thr Val Phe Ala Glu Thr Asn Val Ile 
145                 150                 155                 160 


Thr Arg His Ala Arg Phe Ile Asn His His Ser Ser Pro Val Gln Leu 
                165                 170                 175     


Met Arg Ala Leu Ser Met Ser Val Asp Leu Pro Asp Ala Asp Phe Gln 
            180                 185                 190         


Met Leu Gln Leu Ser Gly Ser Trp Ser Arg Glu Arg Tyr Val Lys Glu 
        195                 200                 205             


Arg Ala Leu Val Pro Gly Ile His Gln Ile Ser Ser Thr Arg Gly Ala 
    210                 215                 220                 


Ser Ser Ser Gln Gln Asn Pro Phe Ile Ala Leu Lys Arg Pro Gln Thr 
225                 230                 235                 240 


Thr Glu Phe His Gly Glu Val Tyr Gly Phe Ser Leu Val Tyr Ser Gly 
                245                 250                 255     


Asn Phe Leu Ala Gln Val Glu Val Asp Gln Tyr Asp Val Ser Arg Val 
            260                 265                 270         


Gln Met Gly Ile His Pro Phe Asp Phe Gln Trp Leu Leu Glu Ala Gly 
        275                 280                 285             


Glu Ser Phe Gln Thr Pro Glu Val Val Met Val Tyr Thr Asp Gln Gly 
    290                 295                 300                 


Leu Asn His Leu Ser Gln Leu Tyr His Ser Leu Tyr Arg Ser Arg Leu 
305                 310                 315                 320 


Val Arg Gly Asn Trp Arg Asp Arg Pro Arg Pro Ile Leu Leu Asn Ser 
                325                 330                 335     


Trp Glu Ala Thr Tyr Phe Asp Phe Thr Glu Asp Ser Leu Val Glu Phe 
            340                 345                 350         


Ala Lys Glu Gly Lys Lys Leu Gly Val Glu Leu Phe Val Leu Asp Asp 
        355                 360                 365             


Gly Trp Phe Gly Thr Arg Asn Asp Asp Thr Thr Ser Leu Gly Asp Trp 
    370                 375                 380                 


Phe Val Asn Ser Glu Lys Leu Pro Asn Gly Ile Glu Gly Leu Ala Glu 
385                 390                 395                 400 


Lys Ile Glu Ala Leu Gly Leu Ala Phe Gly Leu Trp Phe Glu Pro Glu 
                405                 410                 415     


Met Val Asn Lys Glu Ser Glu Leu Phe Lys Lys His Pro Asp Trp Ile 
            420                 425                 430         


Ile His Val Glu Gly Arg Ser Gln Ser His Gly Arg Asn Gln Tyr Val 
        435                 440                 445             


Leu Asp Phe Ser Arg Ala Glu Val Val Asp Ala Ile Tyr Glu Met Met 
    450                 455                 460                 


Ala Glu Leu Leu Arg Lys Ala Pro Ile Ser Tyr Ile Lys Trp Asp Met 
465                 470                 475                 480 


Asn Arg His Leu Thr Glu Ile Gly Ser Pro Ala Trp Pro Lys Glu Arg 
                485                 490                 495     


Gln Gln Glu Ile Ala His Arg Tyr Ile Leu Gly Val Tyr Asp Leu Tyr 
            500                 505                 510         


Glu Arg Leu Val Ser Glu Phe Pro Asp Val Leu Phe Glu Ser Cys Ala 
        515                 520                 525             


Ser Gly Gly Cys Arg Phe Asp Pro Gly Met Leu Tyr Tyr Ala Pro Gln 
    530                 535                 540                 


Thr Trp Thr Ser Asp Asp Thr Asp Ala Ile Glu Arg Leu Lys Ile Gln 
545                 550                 555                 560 


Tyr Gly Thr Ser Met Val Tyr Pro Leu Ser Ser Ile Gly Ala His Val 
                565                 570                 575     


Ser Ala Val Pro Asn His Gln Val Arg Arg Val Thr Ser Leu Glu Thr 
            580                 585                 590         


Arg Gly Asn Val Ala Phe Phe Gly Ala Phe Gly Tyr Glu Leu Asp Val 
        595                 600                 605             


Thr Gln Leu Thr Asp Glu Glu Lys Glu Asn Met Lys Lys Gln Ile Ala 
    610                 615                 620                 


Phe Tyr Lys Glu His Arg Glu Leu Ile Met Phe Gly Thr Phe Tyr Arg 
625                 630                 635                 640 


Leu Arg Ser Pro Phe Val Gly Asp Gly Asn Val Thr Ser Trp Ile Val 
                645                 650                 655     


Val Ser Glu Asp Gln Ser Glu Ala Leu Val Gly Tyr Tyr Gln Thr Leu 
            660                 665                 670         


Ala Lys Val Asn Ala Gly Phe Arg Gln Leu Lys Leu Thr Gly Leu Gln 
        675                 680                 685             


Glu Cys Gly Leu Tyr Gln Ile Asp Gly Met Ile Gly Thr Tyr Gly Gly 
    690                 695                 700                 


Asp Glu Leu Met His Ser Gly Leu Gln Leu Pro Asn Glu Phe Ser Gly 
705                 710                 715                 720 


Ala Ser Ala Leu Arg Glu Asp Glu Gln Ser Gly Asp Phe Gln Ser Tyr 
                725                 730                 735     


Val Phe Lys Leu Lys Arg Ile Glu Ser Asp Arg His 
            740                 745             


<210>  187
<211>  745
<212>  PRT
<213>  Lactobacillus salivarius

<400>  187

Met Pro Ile Thr Tyr Asn Glu Gln Ser Arg Glu Phe His Leu Tyr Asn 
1               5                   10                  15      


Asn Lys Ile Ser Tyr Leu Ile Lys Ile Leu Ala Asn Glu Gln Leu Gly 
            20                  25                  30          


Gln Leu Tyr Phe Gly Lys Arg Ile Pro Asn Arg Gly Asn His Asp Tyr 
        35                  40                  45              


Leu Val Glu Asn Thr Tyr Arg Pro Val Thr Ser Tyr Val Phe Asp Asp 
    50                  55                  60                  


Asp Tyr Ser Phe Ser Leu Gly Asn Val Lys Gln Glu Tyr Pro Ala Tyr 
65                  70                  75                  80  


Gly Thr Thr Asp Gln Arg Arg Pro Ala Leu Asp Ile Lys Gln Pro Asn 
                85                  90                  95      


Gly Ser Arg Ile Thr Asp Phe Lys Tyr Val Ser His Lys Ile Tyr Ala 
            100                 105                 110         


Gly Lys Arg Lys Leu Thr Gly Leu Pro Ala Thr Tyr Val Glu Asp Glu 
        115                 120                 125             


Ser Glu Ala Thr Thr Leu Glu Ile Asn Leu Tyr Asp Glu Leu Ile Gln 
    130                 135                 140                 


Val Thr Leu Cys Leu Gln Tyr Thr Ile Phe Glu Asn Ser Ala Ala Ile 
145                 150                 155                 160 


Ala Arg Ser Val Lys Phe Ser Asn Asn Ser Asp Gln Lys Tyr Gln Leu 
                165                 170                 175     


Lys Thr Ala Leu Ser Leu Asn Leu Asp Leu Pro Asp Ala Asn Tyr Glu 
            180                 185                 190         


Trp Leu Gln Phe Ser Gly Ala Trp Gly Arg Glu Arg His Leu His Lys 
        195                 200                 205             


Thr Pro Leu Arg Pro Gly Ile Gln Ala Ile Asn Ser Ala Arg Gly Ala 
    210                 215                 220                 


Ser Ser His Met Gln Asn Pro Phe Val Ile Leu Lys Arg Pro Phe Thr 
225                 230                 235                 240 


Thr Glu Glu Gln Gly Glu Ala Leu Gly Val Ser Phe Val Tyr Ser Gly 
                245                 250                 255     


Asn Phe Leu Ala Gln Ala Glu Val Asp Glu Tyr Ser Val Thr Arg Leu 
            260                 265                 270         


Gln Ile Gly Ile Asp Pro Phe Gln Phe Ser Trp Cys Leu Lys Pro Asn 
        275                 280                 285             


Glu Thr Phe Gln Thr Pro Glu Ala Ile Leu Ala Tyr Thr Ser Glu Gly 
    290                 295                 300                 


Leu Asn Gln Leu Ser Gln Thr Phe Gln Lys Leu Tyr Thr Thr Arg Leu 
305                 310                 315                 320 


Ala Arg Gly Tyr Trp Arg Asp Lys Glu Arg Pro Ile Leu Ile Asn Asn 
                325                 330                 335     


Trp Glu Ala Thr Tyr Phe Asp Phe Thr Glu Glu Lys Leu Leu Ser Ile 
            340                 345                 350         


Ala Lys Lys Ala Lys Glu Leu Gly Ile Glu Leu Phe Val Leu Asp Asp 
        355                 360                 365             


Gly Trp Phe Gly Glu Arg Thr Lys Glu Thr Ala Gly Leu Gly Asp Trp 
    370                 375                 380                 


Tyr Val Asn Arg Asn Arg Leu Lys Asn Gly Ile Ser Gly Leu Ser Arg 
385                 390                 395                 400 


Lys Ile His Asp Leu Gly Met Met Phe Gly Leu Trp Phe Glu Pro Glu 
                405                 410                 415     


Met Val Asn Lys Asp Ser Asp Leu Tyr Arg Lys His Pro Asp Tyr Ile 
            420                 425                 430         


Ile Glu Thr Pro Lys Arg His Ala Ser His Gly Arg Lys Gln Tyr Val 
        435                 440                 445             


Leu Asp Phe Ser Arg Lys Glu Val Val Asp Asn Ile Tyr Glu Gln Leu 
    450                 455                 460                 


Val Lys Ile Leu Asp Glu Gly Glu Ile Asp Tyr Ile Lys Trp Asp Met 
465                 470                 475                 480 


Asn Arg Asn Ile Thr Glu Cys Tyr Ser Ile Ala Tyr Pro Pro Glu Gln 
                485                 490                 495     


Gln Gly Glu Ile Met His Arg Tyr Ile Leu Gly Val Tyr Asp Leu Tyr 
            500                 505                 510         


Glu Arg Leu Ile Glu Arg Tyr Pro Lys Ile Leu Phe Glu Ser Cys Ala 
        515                 520                 525             


Ser Gly Gly Gly Arg Phe Asp Ala Gly Met Leu Tyr Tyr Ala Pro Gln 
    530                 535                 540                 


Ala Trp Thr Ser Asp Asp Ser Asp Ala Ile Glu Arg Leu Lys Ile Gln 
545                 550                 555                 560 


Tyr Gly Thr Ser Phe Gly Tyr Pro Gln Ser Met Met Gly Ala His Val 
                565                 570                 575     


Ser Ala Ser Pro Asn Glu Gln Leu Gly Arg Asn Thr Pro Leu Lys Ile 
            580                 585                 590         


Arg Gly Asp Val Ala Phe Phe Gly Ala Phe Gly Tyr Glu Leu Asp Leu 
        595                 600                 605             


Asp Lys Leu Ser Ser Thr Glu Leu Ala Ser Ile Lys Lys Gln Ile Glu 
    610                 615                 620                 


Leu Met Lys Lys Tyr Arg Ser Ile Phe Gln Tyr Gly Thr Phe Tyr Arg 
625                 630                 635                 640 


Leu Lys Ser Pro Phe Glu Gly Asn Ile Val Ser Trp Met Val Val Ser 
                645                 650                 655     


Glu Asp Lys Ser Gln Ala Ile Val Gly Tyr Tyr Lys Ile Leu Asn Asp 
            660                 665                 670         


Val Asn Cys Glu Tyr Arg Arg Leu Cys Leu Pro Gly Leu Asp Ala Asp 
        675                 680                 685             


Thr Leu Tyr Asn Val Gln Glu Glu Leu Gly Ser Tyr Leu Gly Asn Phe 
    690                 695                 700                 


Thr Gly Asp Glu Leu Ala Asn Ile Gly Leu Val Thr Thr Asp Ala Ser 
705                 710                 715                 720 


Ala Gly Gln Asn Gln Glu Thr Thr Asp Phe Tyr Ser Lys Leu Phe Ile 
                725                 730                 735     


Leu Glu Arg Cys Gly Glu Leu Ser Asp 
            740                 745 


<210>  188
<211>  729
<212>  PRT
<213>  Lactobacillus reuteri

<400>  188

Met Ile Thr Phe Asp Glu Gln Gln Arg Val Phe His Leu Lys Asn Lys 
1               5                   10                  15      


Glu Ile Ser Tyr Leu Phe Ser Val Glu Glu Gly Asn Ile Leu Ser His 
            20                  25                  30          


Leu Tyr Phe Gly Pro Ala Ile Arg Asn Tyr His Gly Glu Arg Arg Tyr 
        35                  40                  45              


Pro Arg Val Asp Arg Gly Phe Ser Gly Asn Leu Pro Gly Ser Met Asp 
    50                  55                  60                  


Arg Thr Tyr Ser Lys Asp Asp Leu Leu Gln Glu Tyr Ser Gly Asn Asn 
65                  70                  75                  80  


Thr Gly Asp Tyr Arg Val Pro Ala Ile Ile Ile Lys Thr Glu Asn Gly 
                85                  90                  95      


Ser Arg Leu Thr Asp Phe Arg Tyr Lys Ser Tyr Lys Ile Leu Pro Gly 
            100                 105                 110         


Lys Pro Lys Leu Ala Gly Leu Pro Ala Ser Tyr Val Lys Ser Asp Lys 
        115                 120                 125             


Glu Ala Glu Thr Leu Glu Val Ile Leu Val Asp Glu Thr Ile Gly Ala 
    130                 135                 140                 


Gln Leu Ile Leu Ser Tyr Thr Ile Tyr Asn Glu Arg Pro Val Ile Thr 
145                 150                 155                 160 


Arg Asn Ala Arg Leu Val Asn Thr Ser Asn Gln Glu Leu Arg Ile Glu 
                165                 170                 175     


Lys Ile Ala Ser Met Gln Leu Asp Leu Thr Lys His Asp Tyr Asp Val 
            180                 185                 190         


Ile Ser Val Pro Gly Gln Tyr Ala Leu Glu Arg Gln Pro Glu Arg Gln 
        195                 200                 205             


Glu Leu Arg Arg Gly Ile Thr Glu Phe Ser Ser Arg Arg Asn Ser Ser 
    210                 215                 220                 


Ser His His Met Asn Pro Phe Val Ala Leu Val Asp Lys Asn Thr Asp 
225                 230                 235                 240 


Glu Phe Gln Gly Asn Ala Leu Gly Val Leu Leu Val Tyr Ser Gly Asn 
                245                 250                 255     


His Gln Phe Thr Leu Glu Lys Asp Gln Ile Asp Gln Ile Arg Leu Ile 
            260                 265                 270         


Thr Gly Ile Asn Asp Tyr Asp Phe Glu Trp Val Leu Glu Pro Gly Lys 
        275                 280                 285             


Asp Phe Gln Thr Pro Glu Ala Ile Met Gly Phe Ser Gln Gln Gly Leu 
    290                 295                 300                 


Asn Gly Met Ser Gln Val Phe His Lys Leu Leu Arg Asp Arg Val Ala 
305                 310                 315                 320 


Arg Gly Lys Tyr Gln Tyr Ala Asp Arg Pro Ile Val Ile Asn Asn Trp 
                325                 330                 335     


Glu Ala Thr Phe Phe Asp Phe Asp Asp Lys Lys Leu Asp Gln Ile Ile 
            340                 345                 350         


Asp Glu Ala Lys Pro Leu Gly Ile Glu Met Phe Val Leu Asp Asp Gly 
        355                 360                 365             


Trp Phe Gly His Arg Asn Asp Asp Asn Ser Ser Leu Gly Asp Trp Phe 
    370                 375                 380                 


Val Asn Gln Asp Lys Leu Thr Gly Gly Leu Lys Arg Val Ala Asp Arg 
385                 390                 395                 400 


Thr His Glu His Gly Met Lys Phe Gly Leu Trp Phe Glu Pro Glu Met 
                405                 410                 415     


Ile Ser Val Asp Ser Lys Leu Tyr Lys Glu His Pro Asp Tyr Ala Leu 
            420                 425                 430         


His Glu Pro Asn Arg Gly Met Thr Leu Ser Arg Asn Gln Leu Val Leu 
        435                 440                 445             


Asp Phe Ser Arg Lys Glu Val Val Asp Asn Ile Tyr Asn Gln Met Cys 
    450                 455                 460                 


Leu Ile Leu Asp Lys Val Leu Leu Asp Tyr Ile Lys Trp Asp Phe Asn 
465                 470                 475                 480 


Arg Asn Leu Thr Glu Val Phe Ser Ser Ala Ala Asp Ala Asp His Gln 
                485                 490                 495     


Gly Glu Ile Ser His Arg Tyr Val Leu Gly Leu Tyr Asp Leu Met Glu 
            500                 505                 510         


Arg Leu Val Thr Arg Tyr Pro Asn Ile Leu Phe Glu Gly Cys Ser Gly 
        515                 520                 525             


Gly Gly Gly Arg Phe Asp Ala Gly Ile Leu Tyr Tyr Met Pro Gln Ser 
    530                 535                 540                 


Trp Pro Ser Asp Asp Thr Asp Ala Val Glu Arg Leu Lys Ile Gln Tyr 
545                 550                 555                 560 


Gly Thr Ser Leu Thr Tyr Pro Ile Ser Ser Met Thr Ala His Val Ser 
                565                 570                 575     


Val Ser Pro Asn Gln Gln Thr Gly Arg Ser Thr Ser Phe Lys Met Arg 
            580                 585                 590         


Gly Asp Val Ala Met Ser Gly Val Phe Gly Tyr Glu Leu Asp Leu Ala 
        595                 600                 605             


Asp Leu Thr Glu Glu Asp Arg Gln Met Val Lys Glu Gln Ile Lys Phe 
    610                 615                 620                 


Tyr Lys Ala His Arg His Leu Ile Gln Tyr Gly Ala Phe Ile Arg Leu 
625                 630                 635                 640 


Glu Ser Pro Phe Asp Ser Asn Thr Val Ala Trp Glu Phe Val Ser Pro 
                645                 650                 655     


Asp Lys Ser Glu Ala Leu Leu Phe Met Phe Lys Gln Leu His Thr Asn 
            660                 665                 670         


Arg Phe Glu Ile Asn Asn Thr Lys Met Ala Gly Leu Asp Pro Thr Ile 
        675                 680                 685             


Asp Tyr His Asp Glu Met Thr Asp Lys Thr Tyr Gly Gly Asp Glu Leu 
    690                 695                 700                 


Met Asn Val Gly Leu Phe Arg Asp Pro Thr His Thr Gly Asp Phe Ile 
705                 710                 715                 720 


Ser Glu Val His Tyr Phe Lys Gly Glu 
                725                 


<210>  189
<211>  729
<212>  PRT
<213>  Thermoanaerobacter ethanolicus 

<400>  189

Met Pro Ile His Phe Asn Asp Lys Thr Arg Thr Phe His Leu Thr Ala 
1               5                   10                  15      


Lys Asp Thr Ser Tyr Ile Ile His Val Leu Lys Asn Asp Ala Val Leu 
            20                  25                  30          


His Ala Tyr Phe Gly Lys Lys Ile Lys Asn Ala Asn Ile Tyr His Val 
        35                  40                  45              


Leu Lys Leu Ser His Val Ser Ile Asp Thr Asp Asn Ile Asn Phe Gly 
    50                  55                  60                  


Asn Tyr Leu Met Leu Asp Phe Leu Pro Gln Glu Tyr Pro Ala Tyr Gly 
65                  70                  75                  80  


Asn Thr Asp Phe Arg Ser Pro Ala Tyr Gln Ile Gln Leu Glu Asn Gly 
                85                  90                  95      


Ser Thr Val Ser Asp Leu Arg Tyr Leu Ser His Lys Ile Tyr Lys Gly 
            100                 105                 110         


Lys Pro Lys Leu Glu Gly Leu Pro Ala Thr Tyr Val Glu Asn Glu Asp 
        115                 120                 125             


Glu Ala Asp Thr Leu Glu Ile Glu Leu Tyr Asp Lys Val Ala Asn Leu 
    130                 135                 140                 


Lys Val Thr Leu Ile Tyr Thr Ala Phe Arg Asp Tyr Asp Val Ile Thr 
145                 150                 155                 160 


Arg Ser Val Arg Phe Glu Asn Met Gly Lys Glu Asp Ile Lys Leu Leu 
                165                 170                 175     


Arg Ala Leu Ser Met Asn Val Asp Phe Asn Asp Asp Lys Phe Asp Met 
            180                 185                 190         


Leu Gln Leu Ser Gly Ala Trp Ala Arg Glu Arg His Val Ile Arg Arg 
        195                 200                 205             


Pro Leu Thr Pro Gly Val Gln Ser Ile Glu Ser Arg Arg Gly Ala Ser 
    210                 215                 220                 


Ser His Gln Gln Asn Pro Phe Ile Ala Leu Leu Arg Lys Asp Ala Asp 
225                 230                 235                 240 


Glu Trp His Gly Asp Val Tyr Gly Phe Ser Leu Val Tyr Ser Gly Asn 
                245                 250                 255     


Phe Leu Ala Gln Val Glu Val Asp Gln Tyr Lys Met Ala Arg Val Ser 
            260                 265                 270         


Met Gly Ile Asn Pro Phe Asp Phe Ser Trp Leu Leu Lys Pro Gly Glu 
        275                 280                 285             


Thr Phe Gln Thr Pro Glu Val Val Met Val Tyr Ser Asp Ser Gly Leu 
    290                 295                 300                 


Asn Lys Met Ser Asn Thr Tyr His Lys Leu Tyr Arg Asn Arg Leu Met 
305                 310                 315                 320 


Arg Ser Lys Phe Lys Asp Lys Glu Arg Pro Ile Leu Ile Asn Asn Trp 
                325                 330                 335     


Glu Ala Thr Tyr Phe Asp Phe Thr Glu Glu Lys Leu Lys Glu Leu Ala 
            340                 345                 350         


Lys Glu Ala Lys Asp Leu Gly Ile Glu Leu Phe Val Leu Asp Asp Gly 
        355                 360                 365             


Trp Phe Gly Lys Arg Asn Ser Asp Asn Ser Ser Leu Gly Asp Trp Phe 
    370                 375                 380                 


Val Asn Lys Glu Lys Ile Pro Ser Gly Leu Asp Gly Leu Ala Lys Gly 
385                 390                 395                 400 


Ile Asn Ser Leu Gly Leu Lys Phe Gly Leu Trp Met Glu Pro Glu Met 
                405                 410                 415     


Val Ser Pro Asp Ser Asp Leu Tyr Arg Glu His Pro Asn Trp Cys Ile 
            420                 425                 430         


His Val Pro Asn Arg Pro Arg Ser Glu Ser Arg Asn Gln Leu Val Leu 
        435                 440                 445             


Asp Leu Ser Arg Lys Asp Val Gln Asp Tyr Ile Ile Lys Val Val Ser 
    450                 455                 460                 


Asp Ile Leu Glu Ser Ala Asn Ile Ser Tyr Val Lys Trp Asp Met Asn 
465                 470                 475                 480 


Arg Asn Met Thr Glu Ile Gly Ser Ala Leu Leu Pro Pro Glu Arg Gln 
                485                 490                 495     


Arg Glu Thr Ala His Arg Tyr Ile Leu Gly Leu Tyr Arg Ile Leu Glu 
            500                 505                 510         


Glu Ile Thr Thr Arg Phe Pro Asp Val Leu Phe Glu Ser Cys Ala Gly 
        515                 520                 525             


Gly Gly Gly Arg Phe Asp Pro Gly Met Leu Tyr Tyr Met Pro Gln Thr 
    530                 535                 540                 


Trp Thr Ser Asp Asn Thr Asp Ala Val Glu Arg Leu Lys Ile Gln Tyr 
545                 550                 555                 560 


Gly Thr Ser Ile Val Tyr Pro Leu Ile Ser Met Gly Ser His Val Ser 
                565                 570                 575     


Ala Val Pro Asn His Gln Val His Arg Ile Thr Pro Leu Lys Thr Arg 
            580                 585                 590         


Leu Asp Val Ala Ile Ser Gly Asn Phe Gly Phe Glu Leu Asp Leu Thr 
        595                 600                 605             


Lys Leu Ser Glu Glu Glu Lys Asp Leu Ala Lys Lys Tyr Val Lys Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Arg Lys Leu Ile Gln Phe Gly Asp Phe Tyr Arg Leu 
625                 630                 635                 640 


Leu Ser Pro Phe Glu Gly Asn Glu Thr Ala Trp Met Phe Ile Asn Glu 
                645                 650                 655     


Glu Lys Thr Glu Phe Val Ala Phe Tyr Phe Lys Val Leu Ala Thr Pro 
            660                 665                 670         


Asn Asp Thr Ile Lys Arg Ile Tyr Leu Lys Ala Leu Asn Pro Asp Tyr 
        675                 680                 685             


Lys Tyr Ala Leu Gln Asp Thr Gly Glu Val Tyr Gly Gly Asp Glu Leu 
    690                 695                 700                 


Met Tyr Ala Gly Ile Ala Ile Pro Gln Leu Glu Gly Asp Phe Gln Ser 
705                 710                 715                 720 


Val Met Met His Phe Lys Lys Glu Ala 
                725                 


<210>  190
<211>  733
<212>  PRT
<213>  Thermoanaerobacter ethanolicus

<400>  190

Met Ser Ile His Phe Asn Asp Lys Thr Lys Thr Phe Tyr Leu Thr Ala 
1               5                   10                  15      


Lys Asp Thr Ser Tyr Val Ile Tyr Val Leu Lys Asn Gly Ala Val Leu 
            20                  25                  30          


His Ala Tyr Phe Gly Lys Ile Ile Lys Thr Pro Asn Ile Tyr His Leu 
        35                  40                  45              


Leu Lys Leu Pro His Ile Ser Ile Asp Asn Asp Ile Ile Asn Phe Gly 
    50                  55                  60                  


Asn Gln Leu Met Leu Asp Phe Leu Pro Gln Glu Tyr Pro Ala Tyr Gly 
65                  70                  75                  80  


Asn Thr Asp Phe Arg Ser Pro Ala Tyr Gln Ile Gln Leu Glu Asn Gly 
                85                  90                  95      


Ser Thr Val Ser Asp Leu Arg Tyr Leu Ser His Lys Ile Tyr Lys Gly 
            100                 105                 110         


Lys Pro Lys Leu Glu Gly Leu Pro Ala Thr Tyr Val Glu Asn Glu Asp 
        115                 120                 125             


Glu Ala Asp Thr Leu Glu Leu Glu Leu Tyr Asp Lys Val Ala Asn Leu 
    130                 135                 140                 


Lys Val Thr Leu Ile Tyr Thr Ala Phe Arg Asp Tyr Asp Val Ile Thr 
145                 150                 155                 160 


Arg Ser Val Arg Phe Glu Asn Met Gly Lys Glu Asp Ile Lys Leu Leu 
                165                 170                 175     


Arg Ala Leu Ser Met Asn Val Asp Phe Asn Asp Ser Asn Phe Asp Met 
            180                 185                 190         


Leu Gln Leu Ser Gly Ala Trp Ala Arg Glu Arg His Val Ile Arg Arg 
        195                 200                 205             


Pro Leu Val Pro Gly Ala Gln Ser Ile Glu Ser Arg Arg Gly Ala Ser 
    210                 215                 220                 


Ser His Gln Gln Asn Pro Phe Ile Ala Leu Leu Arg Asn Asp Ala Asp 
225                 230                 235                 240 


Glu Trp His Gly Asp Val Tyr Gly Phe Ser Leu Val Tyr Ser Gly Asn 
                245                 250                 255     


Phe Leu Ala Gln Val Glu Val Asp Gln Tyr Asn Met Ala Arg Val Ser 
            260                 265                 270         


Met Gly Ile Asn Pro Phe Asp Phe Ser Trp Leu Leu Lys Pro Gly Glu 
        275                 280                 285             


Thr Phe Gln Thr Pro Glu Val Val Met Val Tyr Ser Asp Gly Gly Leu 
    290                 295                 300                 


Asn Lys Met Ser Asn Thr Tyr His Lys Leu Tyr Arg Asn Arg Leu Met 
305                 310                 315                 320 


Arg Ser Lys Phe Lys Asp Arg Glu Thr Pro Ile Leu Ile Asn Asn Trp 
                325                 330                 335     


Glu Ala Thr Tyr Phe Asp Phe Thr Glu Glu Lys Leu Lys Glu Leu Ala 
            340                 345                 350         


Lys Glu Ala Lys Asp Leu Gly Ile Glu Leu Phe Val Leu Asp Asp Gly 
        355                 360                 365             


Trp Phe Gly Lys Arg Asn Ser Asp Asn Ser Ser Leu Gly Asp Trp Phe 
    370                 375                 380                 


Val Asn Lys Glu Lys Ile Pro Ser Gly Leu Asp Gly Leu Ala Lys Gly 
385                 390                 395                 400 


Ile Asn Ser Leu Gly Leu Lys Phe Gly Leu Trp Met Glu Pro Glu Met 
                405                 410                 415     


Val Ser Pro Asp Ser Asp Leu Tyr Arg Glu His Pro Asp Trp Cys Ile 
            420                 425                 430         


His Val Pro Asn Arg Ser Arg Ser Glu Ser Arg Asn Gln Leu Val Leu 
        435                 440                 445             


Asp Leu Ser Arg Lys Asp Val Gln Asp Tyr Ile Ile Lys Val Val Ser 
    450                 455                 460                 


Asp Ile Leu Glu Ser Ala Asn Ile Ser Tyr Val Lys Trp Asp Met Asn 
465                 470                 475                 480 


Arg Asn Met Thr Glu Ile Gly Ser Ala Leu Leu Pro Pro Glu Arg Gln 
                485                 490                 495     


Arg Glu Thr Ala His Arg Tyr Ile Leu Gly Leu Tyr Arg Ile Leu Glu 
            500                 505                 510         


Glu Ile Thr Thr Arg Phe Pro Asp Val Leu Phe Glu Ser Cys Ala Gly 
        515                 520                 525             


Gly Gly Gly Arg Phe Asp Pro Gly Met Leu Tyr Tyr Met Pro Gln Thr 
    530                 535                 540                 


Trp Thr Ser Asp Asp Thr Asp Ala Ile Glu Arg Leu Lys Ile Gln Tyr 
545                 550                 555                 560 


Gly Thr Ser Ile Val Tyr Pro Leu Ile Ser Met Gly Ser His Ile Ser 
                565                 570                 575     


Ala Val Pro Asn His Gln Val His Arg Ile Thr Pro Leu Lys Ile Arg 
            580                 585                 590         


Ala His Val Ala Met Ser Ala Asn Phe Gly Phe Glu Leu Asp Leu Thr 
        595                 600                 605             


Lys Leu Ser Ser Glu Glu Lys Asp Glu Ile Lys Lys Tyr Val Glu Lys 
    610                 615                 620                 


Tyr Lys Glu Ile Arg Lys Leu Val Gln Phe Gly Asp Phe Tyr Arg Leu 
625                 630                 635                 640 


Leu Ser Pro Phe Glu Gly Asn Glu Thr Ala Trp Leu Ile Val Ser Glu 
                645                 650                 655     


Asp Lys Arg Glu Phe Leu Leu Tyr Tyr Phe Arg Val Leu Gly Gly Ala 
            660                 665                 670         


Asn Glu Pro Ile Lys Arg Leu Arg Leu Lys Gly Ile Asn Pro Asp Phe 
        675                 680                 685             


Asn Tyr Val Leu Glu Asp Asp Gly Ser Glu Tyr Ser Gly Asp Glu Leu 
    690                 695                 700                 


Met Tyr Ala Gly Lys Val Ile Pro Glu Leu Lys Gly Asp Phe Gln Ser 
705                 710                 715                 720 


Ile Met Met His Phe Lys Glu Glu Ser Ile Lys Asp Gly 
                725                 730             


<210>  191
<211>  2244
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 184

<400>  191
gtggcgattg ggaaaggacg accttcgatg cccatcatct ttcactcgga tgagcgcctg     60

tttcacctga tgacgccgag atcgagctac atatttcgcg tcggccatga cggcttattg    120

gaacacgtct actggggcgc caggttggaa gacgcgtcgg acctggtccg cctggcgcgc    180

gcttgccagc ggctcgatgc gcggccggag cacatgcgcg ccatcgacat cggctcgctt    240

cgcctcgagt acccctcatt cgggacgggc gaccaccgcg atcctgccta cgaggtcttg    300

cagccttcgg gcagccacgc gtcccagctc gtgtacgaat cccaccagat ccgacctggc    360

aagccgccgc ttccgggcct gcctgcgttt tacgtcgaat ccgatttcga agcggacacg    420

ctcgagattt cgctggtcga tccggccatc tcgctgcgcg tgatcctctc ctacaccgcc    480

taccgcgact tcgatctcgt ctgccgccac gcgcgcttgg agaatgcggg taccgaaccg    540

ctcgtcctgc gccgggcgct ctccgcatct gtcgatctcg acctgcggga ggcggacttc    600

gtccaactct ccggcgcctg gatccgcgag cggttcatcc aacggacgcc gctttcgcct    660

gggcggcatg agatcatgag ccgctccggc gcgagcggtc acaagcacaa cccgttcttc    720

gccctcgcgg cgccgcatac gacggaggaa ggcggcgagg tgcgcgcgtt cgctctcgtg    780

tacagcggca attttctcgg cgcctgcgag atggagccca tgcggcaaaa cgtgcgcgcg    840

cagatcggca tccacccttc cgatttctcc tggcgcctcg aacccggcga gcggtttgtc    900

acgcccgagg cggcgctcgt ctactcggac gagggatggg gcggtatgtc gcgcacgttc    960

caccgcgcca ttcgaaagag gctgtgccga gggacctatc gcgatcgcgt ccgccccgtg   1020

ctcatcaaca attgggaagc gacgtacttc catttcgacg aggaagatct cgtcgagatc   1080

gcagagcaag cccgcgatct cggcgcggag atgttcgtcc tcgacgacgg ctggttcggc   1140

cagcgcgacg acgatcacac gtcgctcggc gactggtggc cgcacccgcg caaactgccg   1200

aacgggctgc gccatctcgc cgatcgcatc cacgcgctcg ggcttcgctt cggcatctgg   1260

atggagccgg agatggtgtc gccgaagagc gagctgtatc gtgagcatcc ggattggtgc   1320

ctgcacgtgg cggatcggcc gagatcggag cgaaggcatc agctgatgct cgacctcacg   1380

cgcgaggatg tgcgcgcctt cgtggtgaac gcggtgtcgc gcgtgatcga agaaggggcc   1440

gtcgattaca tcaagtggga catgaatcgg ccgatgaccg aggtcggatc ggccgcgctt   1500

ccgcctgagc gccagcgcga ggtcgcgcac cgctacgtgc tcgggctgta cgagatcctg   1560

gagacgctca cgagccgatt cccgaacgtg ctatttgaaa actgcgcctc gggcgggggc   1620

aggttcgaac tcggcatgct ccactacatg ccgcagacgt ggacgagcga caacacggac   1680

gccgtctccc ggctgaagat ccagcacggc acgagcctcg tctatccgcc agtcgcgatg   1740

ggcgcgcacg tgtcggccgt tccaaaccac cagatggggc gcgtcacgcc gttcgccctc   1800

cgcgccggcg tcgccatgtg cggcaacttc ggcttcgagc tcgatccgcg gcgcctttcg   1860

gacgcggagc ggcgcgaggc gcgtcaggcg gtggagcggt acaaagcgct tcgacacctc   1920

gtgcagttcg gcgacttcta ccggctgctg tccccgtttg acgggcccga ggcggcctgg   1980

atgttcgctg tcgaggatgg cagcgaggcg ctcgtcgcct atttctgcac gtatccggat   2040

cccttggatc cgccggcgcg cgtggtcctg cgcggcctgc ggcccgaggc gcgctatagg   2100

tgtgaggcgc tcggcgagag cttccgcggc gacgcactga tgcgccacgg cctcgtcatt   2160

ccgcgccagg tgggcgacgg gcaggccgtg ctcattcatc tcaagcaaat cggggaaggt   2220

gatcgcccgt gagatcgccc gtga                                          2244


<210>  192
<211>  2232
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 184

<400>  192
gtggcgattg ggaaaggacg accttcgatg cccatcatct ttcactcgga tgagcgcctg     60

tttcacctga tgacgccgag atcgagctac ctgtttcgcg tcggccatga cggcttattg    120

gaacacgtct actggggcgc caggttggaa gacgcgtcgg acctggtccg cctggcgcgc    180

gcttgccagc ggctcgatgc gcggccggag cacatgcgcg ccatcgacat cggctcgctt    240

cgcctcgagt acccctcatt cgggacgggc gaccaccgcg atcctgccta cgaggtcttg    300

cagccttcgg gcagccacgc gtcccagctc gtgtacgaat cccaccagat ccgacctggc    360

aagccgccgc ttccgggcct gcctgcgttt tacgtcgaat ccgatttcga agcggacacg    420

ctcgagattt cgctggtcga tccggccatc tcgctgcgcg tgatcctctc ctacaccgcc    480

taccgcgact tcgatctcgt ctgccgccac gcgcgcttgg agaatgcggg taccgaaccg    540

ctcgtcctgc gccgggcgct ctccgcatct gtcgatctcg acctgcggga ggcggacttc    600

gtccaactct ccggcgcctg gatccgcgag cggttcatcc aacggacgcc gctttcgcct    660

gggcggcatg agatcatgag ccgctccggc gcgagcggtc acaagcacaa cccgttcttc    720

gccctcgcgg cgccgcatac gacggaggaa ggcggcgagg tgcgcgcgtt cgctctcgtg    780

tacagcggca attttctcgg cgcctgcgag atggagccca tgcggcaaaa cgtgcgcgcg    840

cagatcggca tccacccttc cgatttctcc tggcgcctcg aacccggcga gcggtttgtc    900

acgcccgagg cggcgctcgt ctactcggac gagggatggg gcggtatgtc gcgcacgttc    960

caccgcgcca ttcgaaagag gctgtgccga gggacctatc gcgatcgcgt ccgccccgtg   1020

ctcatcaaca attgggaagc gacgtacttc catttcgacg aggaagatct cgtcgagatc   1080

gcagagcaag cccgcgatct cggcgcggag atgttcgtcc tcgacgacgg ctggttcggc   1140

cagcgcgacg acgatcacac gtcgctcggc gactggtggc cgcacccgcg caaactgccg   1200

aacgggctgc gccatctcgc cgatcgcatc cacgcgctcg ggcttcgctt cggcatctgg   1260

atggagccgg agatggtgtc gccgaagagc gagctgtatc gtgagcatcc ggattggtgc   1320

ctgcacgtgg cggatcggcc gagatcggag cgaaggcatc agctgatgct cgacctcacg   1380

cgcgaggatg tgcgcgcctt cgtggtgaac gcggtgtcgc gcgtgatcga agaaggggcc   1440

gtcgattaca tcaagtggga catgaatcgg ccgatgaccg aggtcggatc ggccgcgctt   1500

ccgcctgagc gccagcgcga ggtcgcgcac cgctacgtgc tcgggctgta cgagatcctg   1560

gagacgctca cgagccgatt cccgaacgtg ctatttgaaa actgcgcctc gggcgggggc   1620

aggttcgaac tcggcatgct ccactacatg ccgcagacgt ggacgagcga caacacggac   1680

gccgtctccc ggctgaagat ccagcacggc acgagcctcg tctatccgcc agtcgcgatg   1740

ggcgcgcacg tgtcggccgt tccaaaccac cagatggggc gcgtcacgcc gttcgccctc   1800

cgcgccggcg tcgccatgtg cggcaacttc ggcttcgagc tcgatccgcg gcgcctttcg   1860

gacgcggagc ggcgcgaggc gcgtcaggcg gtggagcggt acaaagcgct tcgacacctc   1920

gtgcagttcg gcgacttcta ccggctgctg tccccgtttg acgggcccga ggcggcctgg   1980

atgttcgctg tcgaggatgg cagcgaggcg ctcgtcgcct atttctgcac gtatccggat   2040

cccttggatc cgccggcgcg cgtggtcctg cgcggcctgc ggcccgaggc gcgctatagg   2100

tgtgaggcgc tcggcgagag cttccgcggc gacgcactga tgcgccacgg cctcgtcatt   2160

ccgcgccagg tgggcgacgg gcaggccgtg ctcattcatc tcaagcaaat cggggaaggt   2220

gatcgcccgt ga                                                       2232


<210>  193
<211>  2232
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 184

<400>  193
gtggcgattg ggaaaggacg accttcgatg cccatcatct ttcactcgga tgagcgcctg     60

tttcacctga tgacgccgag atcgagctac gtgtttaaag tcggccatga cggcttattg    120

gaacacgtct actggggcgc caggttggaa gacgcgtcgg acctggtccg cctggcgcgc    180

gcttgccagc ggctcgatgc gcggccggag cacatgcgcg ccatcgacat cggctcgctt    240

cgcctcgagt acccctcatt cgggacgggc gaccaccgcg atcctgccta cgaggtcttg    300

cagccttcgg gcagccacgc gtcccagctc gtgtacgaat cccaccagat ccgacctggc    360

aagccgccgc ttccgggcct gcctgcgttt tacgtcgaat ccgatttcga agcggacacg    420

ctcgagattt cgctggtcga tccggccatc tcgctgcgcg tgatcctctc ctacaccgcc    480

taccgcgact tcgatctcgt ctgccgccac gcgcgcttgg agaatgcggg taccgaaccg    540

ctcgtcctgc gccgggcgct ctccgcatct gtcgatctcg acctgcggga ggcggacttc    600

gtccaactct ccggcgcctg gatccgcgag cggttcatcc aacggacgcc gctttcgcct    660

gggcggcatg agatcatgag ccgctccggc gcgagcggtc acaagcacaa cccgttcttc    720

gccctcgcgg cgccgcatac gacggaggaa ggcggcgagg tgcgcgcgtt cgctctcgtg    780

tacagcggca attttctcgg cgcctgcgag atggagccca tgcggcaaaa cgtgcgcgcg    840

cagatcggca tccacccttc cgatttctcc tggcgcctcg aacccggcga gcggtttgtc    900

acgcccgagg cggcgctcgt ctactcggac gagggatggg gcggtatgtc gcgcacgttc    960

caccgcgcca ttcgaaagag gctgtgccga gggacctatc gcgatcgcgt ccgccccgtg   1020

ctcatcaaca attgggaagc gacgtacttc catttcgacg aggaagatct cgtcgagatc   1080

gcagagcaag cccgcgatct cggcgcggag atgttcgtcc tcgacgacgg ctggttcggc   1140

cagcgcgacg acgatcacac gtcgctcggc gactggtggc cgcacccgcg caaactgccg   1200

aacgggctgc gccatctcgc cgatcgcatc cacgcgctcg ggcttcgctt cggcatctgg   1260

atggagccgg agatggtgtc gccgaagagc gagctgtatc gtgagcatcc ggattggtgc   1320

ctgcacgtgg cggatcggcc gagatcggag cgaaggcatc agctgatgct cgacctcacg   1380

cgcgaggatg tgcgcgcctt cgtggtgaac gcggtgtcgc gcgtgatcga agaaggggcc   1440

gtcgattaca tcaagtggga catgaatcgg ccgatgaccg aggtcggatc ggccgcgctt   1500

ccgcctgagc gccagcgcga ggtcgcgcac cgctacgtgc tcgggctgta cgagatcctg   1560

gagacgctca cgagccgatt cccgaacgtg ctatttgaaa actgcgcctc gggcgggggc   1620

aggttcgaac tcggcatgct ccactacatg ccgcagacgt ggacgagcga caacacggac   1680

gccgtctccc ggctgaagat ccagcacggc acgagcctcg tctatccgcc agtcgcgatg   1740

ggcgcgcacg tgtcggccgt tccaaaccac cagatggggc gcgtcacgcc gttcgccctc   1800

cgcgccggcg tcgccatgtg cggcaacttc ggcttcgagc tcgatccgcg gcgcctttcg   1860

gacgcggagc ggcgcgaggc gcgtcaggcg gtggagcggt acaaagcgct tcgacacctc   1920

gtgcagttcg gcgacttcta ccggctgctg tccccgtttg acgggcccga ggcggcctgg   1980

atgttcgctg tcgaggatgg cagcgaggcg ctcgtcgcct atttctgcac gtatccggat   2040

cccttggatc cgccggcgcg cgtggtcctg cgcggcctgc ggcccgaggc gcgctatagg   2100

tgtgaggcgc tcggcgagag cttccgcggc gacgcactga tgcgccacgg cctcgtcatt   2160

ccgcgccagg tgggcgacgg gcaggccgtg ctcattcatc tcaagcaaat cggggaaggt   2220

gatcgcccgt ga                                                       2232


<210>  194
<211>  2232
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 184

<400>  194
gtggcgattg ggaaaggacg accttcgatg cccatcatct ttcactcgga tgagcgcctg     60

tttcacctga tgacgccgag atcgagctac gtgtttcgcg tcggccatga cggcatattg    120

gaacacgtct actggggcgc caggttggaa gacgcgtcgg acctggtccg cctggcgcgc    180

gcttgccagc ggctcgatgc gcggccggag cacatgcgcg ccatcgacat cggctcgctt    240

cgcctcgagt acccctcatt cgggacgggc gaccaccgcg atcctgccta cgaggtcttg    300

cagccttcgg gcagccacgc gtcccagctc gtgtacgaat cccaccagat ccgacctggc    360

aagccgccgc ttccgggcct gcctgcgttt tacgtcgaat ccgatttcga agcggacacg    420

ctcgagattt cgctggtcga tccggccatc tcgctgcgcg tgatcctctc ctacaccgcc    480

taccgcgact tcgatctcgt ctgccgccac gcgcgcttgg agaatgcggg taccgaaccg    540

ctcgtcctgc gccgggcgct ctccgcatct gtcgatctcg acctgcggga ggcggacttc    600

gtccaactct ccggcgcctg gatccgcgag cggttcatcc aacggacgcc gctttcgcct    660

gggcggcatg agatcatgag ccgctccggc gcgagcggtc acaagcacaa cccgttcttc    720

gccctcgcgg cgccgcatac gacggaggaa ggcggcgagg tgcgcgcgtt cgctctcgtg    780

tacagcggca attttctcgg cgcctgcgag atggagccca tgcggcaaaa cgtgcgcgcg    840

cagatcggca tccacccttc cgatttctcc tggcgcctcg aacccggcga gcggtttgtc    900

acgcccgagg cggcgctcgt ctactcggac gagggatggg gcggtatgtc gcgcacgttc    960

caccgcgcca ttcgaaagag gctgtgccga gggacctatc gcgatcgcgt ccgccccgtg   1020

ctcatcaaca attgggaagc gacgtacttc catttcgacg aggaagatct cgtcgagatc   1080

gcagagcaag cccgcgatct cggcgcggag atgttcgtcc tcgacgacgg ctggttcggc   1140

cagcgcgacg acgatcacac gtcgctcggc gactggtggc cgcacccgcg caaactgccg   1200

aacgggctgc gccatctcgc cgatcgcatc cacgcgctcg ggcttcgctt cggcatctgg   1260

atggagccgg agatggtgtc gccgaagagc gagctgtatc gtgagcatcc ggattggtgc   1320

ctgcacgtgg cggatcggcc gagatcggag cgaaggcatc agctgatgct cgacctcacg   1380

cgcgaggatg tgcgcgcctt cgtggtgaac gcggtgtcgc gcgtgatcga agaaggggcc   1440

gtcgattaca tcaagtggga catgaatcgg ccgatgaccg aggtcggatc ggccgcgctt   1500

ccgcctgagc gccagcgcga ggtcgcgcac cgctacgtgc tcgggctgta cgagatcctg   1560

gagacgctca cgagccgatt cccgaacgtg ctatttgaaa actgcgcctc gggcgggggc   1620

aggttcgaac tcggcatgct ccactacatg ccgcagacgt ggacgagcga caacacggac   1680

gccgtctccc ggctgaagat ccagcacggc acgagcctcg tctatccgcc agtcgcgatg   1740

ggcgcgcacg tgtcggccgt tccaaaccac cagatggggc gcgtcacgcc gttcgccctc   1800

cgcgccggcg tcgccatgtg cggcaacttc ggcttcgagc tcgatccgcg gcgcctttcg   1860

gacgcggagc ggcgcgaggc gcgtcaggcg gtggagcggt acaaagcgct tcgacacctc   1920

gtgcagttcg gcgacttcta ccggctgctg tccccgtttg acgggcccga ggcggcctgg   1980

atgttcgctg tcgaggatgg cagcgaggcg ctcgtcgcct atttctgcac gtatccggat   2040

cccttggatc cgccggcgcg cgtggtcctg cgcggcctgc ggcccgaggc gcgctatagg   2100

tgtgaggcgc tcggcgagag cttccgcggc gacgcactga tgcgccacgg cctcgtcatt   2160

ccgcgccagg tgggcgacgg gcaggccgtg ctcattcatc tcaagcaaat cggggaaggt   2220

gatcgcccgt ga                                                       2232


<210>  195
<211>  2232
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 184

<400>  195
gtggcgattg ggaaaggacg accttcgatg cccatcatct ttcactcgca agagcgcctg     60

tttcacctga tgacgccgag atcgagctac gtgtttcgcg tcggccatga cggcttattg    120

gaacacgtct actggggcgc caggttggaa gacgcgtcgg acctggtccg cctggcgcgc    180

gcttgccagc ggctcgatgc gcggccggag cacatgcgcg ccatcgacat cggctcgctt    240

cgcctcgagt acccctcatt cgggacgggc gaccaccgcg atcctgccta cgaggtcttg    300

cagccttcgg gcagccacgc gtcccagctc gtgtacgaat cccaccagat ccgacctggc    360

aagccgccgc ttccgggcct gcctgcgttt tacgtcgaat ccgatttcga agcggacacg    420

ctcgagattt cgctggtcga tccggccatc tcgctgcgcg tgatcctctc ctacaccgcc    480

taccgcgact tcgatctcgt ctgccgccac gcgcgcttgg agaatgcggg taccgaaccg    540

ctcgtcctgc gccgggcgct ctccgcatct gtcgatctcg acctgcggga ggcggacttc    600

gtccaactct ccggcgcctg gatccgcgag cggttcatcc aacggacgcc gctttcgcct    660

gggcggcatg agatcatgag ccgctccggc gcgagcggtc acaagcacaa cccgttcttc    720

gccctcgcgg cgccgcatac gacggaggaa ggcggcgagg tgcgcgcgtt cgctctcgtg    780

tacagcggca attttctcgg cgcctgcgag atggagccca tgcggcaaaa cgtgcgcgcg    840

cagatcggca tccacccttc cgatttctcc tggcgcctcg aacccggcga gcggtttgtc    900

acgcccgagg cggcgctcgt ctactcggac gagggatggg gcggtatgtc gcgcacgttc    960

caccgcgcca ttcgaaagag gctgtgccga gggacctatc gcgatcgcgt ccgccccgtg   1020

ctcatcaaca attgggaagc gacgtacttc catttcgacg aggaagatct cgtcgagatc   1080

gcagagcaag cccgcgatct cggcgcggag atgttcgtcc tcgacgacgg ctggttcggc   1140

cagcgcgacg acgatcacac gtcgctcggc gactggtggc cgcacccgcg caaactgccg   1200

aacgggctgc gccatctcgc cgatcgcatc cacgcgctcg ggcttcgctt cggcatctgg   1260

atggagccgg agatggtgtc gccgaagagc gagctgtatc gtgagcatcc ggattggtgc   1320

ctgcacgtgg cggatcggcc gagatcggag cgaaggcatc agctgatgct cgacctcacg   1380

cgcgaggatg tgcgcgcctt cgtggtgaac gcggtgtcgc gcgtgatcga agaaggggcc   1440

gtcgattaca tcaagtggga catgaatcgg ccgatgaccg aggtcggatc ggccgcgctt   1500

ccgcctgagc gccagcgcga ggtcgcgcac cgctacgtgc tcgggctgta cgagatcctg   1560

gagacgctca cgagccgatt cccgaacgtg ctatttgaaa actgcgcctc gggcgggggc   1620

aggttcgaac tcggcatgct ccactacatg ccgcagacgt ggacgagcga caacacggac   1680

gccgtctccc ggctgaagat ccagcacggc acgagcctcg tctatccgcc agtcgcgatg   1740

ggcgcgcacg tgtcggccgt tccaaaccac cagatggggc gcgtcacgcc gttcgccctc   1800

cgcgccggcg tcgccatgtg cggcaacttc ggcttcgagc tcgatccgcg gcgcctttcg   1860

gacgcggagc ggcgcgaggc gcgtcaggcg gtggagcggt acaaagcgct tcgacacctc   1920

gtgcagttcg gcgacttcta ccggctgctg tccccgtttg acgggcccga ggcggcctgg   1980

atgttcgctg tcgaggatgg cagcgaggcg ctcgtcgcct atttctgcac gtatccggat   2040

cccttggatc cgccggcgcg cgtggtcctg cgcggcctgc ggcccgaggc gcgctatagg   2100

tgtgaggcgc tcggcgagag cttccgcggc gacgcactga tgcgccacgg cctcgtcatt   2160

ccgcgccagg tgggcgacgg gcaggccgtg ctcattcatc tcaagcaaat cggggaaggt   2220

gatcgcccgt ga                                                       2232


<210>  196
<211>  743
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:185 and encoded by SEQ ID NO:191

<400>  196

Met Ala Ile Gly Lys Gly Arg Pro Ser Met Pro Ile Ile Phe His Ser 
1               5                   10                  15      


Asp Glu Arg Leu Phe His Leu Met Thr Pro Arg Ser Ser Tyr Ile Phe 
            20                  25                  30          


Arg Val Gly His Asp Gly Leu Leu Glu His Val Tyr Trp Gly Ala Arg 
        35                  40                  45              


Leu Glu Asp Ala Ser Asp Leu Val Arg Leu Ala Arg Ala Cys Gln Arg 
    50                  55                  60                  


Leu Asp Ala Arg Pro Glu His Met Arg Ala Ile Asp Ile Gly Ser Leu 
65                  70                  75                  80  


Arg Leu Glu Tyr Pro Ser Phe Gly Thr Gly Asp His Arg Asp Pro Ala 
                85                  90                  95      


Tyr Glu Val Leu Gln Pro Ser Gly Ser His Ala Ser Gln Leu Val Tyr 
            100                 105                 110         


Glu Ser His Gln Ile Arg Pro Gly Lys Pro Pro Leu Pro Gly Leu Pro 
        115                 120                 125             


Ala Phe Tyr Val Glu Ser Asp Phe Glu Ala Asp Thr Leu Glu Ile Ser 
    130                 135                 140                 


Leu Val Asp Pro Ala Ile Ser Leu Arg Val Ile Leu Ser Tyr Thr Ala 
145                 150                 155                 160 


Tyr Arg Asp Phe Asp Leu Val Cys Arg His Ala Arg Leu Glu Asn Ala 
                165                 170                 175     


Gly Thr Glu Pro Leu Val Leu Arg Arg Ala Leu Ser Ala Ser Val Asp 
            180                 185                 190         


Leu Asp Leu Arg Glu Ala Asp Phe Val Gln Leu Ser Gly Ala Trp Ile 
        195                 200                 205             


Arg Glu Arg Phe Ile Gln Arg Thr Pro Leu Ser Pro Gly Arg His Glu 
    210                 215                 220                 


Ile Met Ser Arg Ser Gly Ala Ser Gly His Lys His Asn Pro Phe Phe 
225                 230                 235                 240 


Ala Leu Ala Ala Pro His Thr Thr Glu Glu Gly Gly Glu Val Arg Ala 
                245                 250                 255     


Phe Ala Leu Val Tyr Ser Gly Asn Phe Leu Gly Ala Cys Glu Met Glu 
            260                 265                 270         


Pro Met Arg Gln Asn Val Arg Ala Gln Ile Gly Ile His Pro Ser Asp 
        275                 280                 285             


Phe Ser Trp Arg Leu Glu Pro Gly Glu Arg Phe Val Thr Pro Glu Ala 
    290                 295                 300                 


Ala Leu Val Tyr Ser Asp Glu Gly Trp Gly Gly Met Ser Arg Thr Phe 
305                 310                 315                 320 


His Arg Ala Ile Arg Lys Arg Leu Cys Arg Gly Thr Tyr Arg Asp Arg 
                325                 330                 335     


Val Arg Pro Val Leu Ile Asn Asn Trp Glu Ala Thr Tyr Phe His Phe 
            340                 345                 350         


Asp Glu Glu Asp Leu Val Glu Ile Ala Glu Gln Ala Arg Asp Leu Gly 
        355                 360                 365             


Ala Glu Met Phe Val Leu Asp Asp Gly Trp Phe Gly Gln Arg Asp Asp 
    370                 375                 380                 


Asp His Thr Ser Leu Gly Asp Trp Trp Pro His Pro Arg Lys Leu Pro 
385                 390                 395                 400 


Asn Gly Leu Arg His Leu Ala Asp Arg Ile His Ala Leu Gly Leu Arg 
                405                 410                 415     


Phe Gly Ile Trp Met Glu Pro Glu Met Val Ser Pro Lys Ser Glu Leu 
            420                 425                 430         


Tyr Arg Glu His Pro Asp Trp Cys Leu His Val Ala Asp Arg Pro Arg 
        435                 440                 445             


Ser Glu Arg Arg His Gln Leu Met Leu Asp Leu Thr Arg Glu Asp Val 
    450                 455                 460                 


Arg Ala Phe Val Val Asn Ala Val Ser Arg Val Ile Glu Glu Gly Ala 
465                 470                 475                 480 


Val Asp Tyr Ile Lys Trp Asp Met Asn Arg Pro Met Thr Glu Val Gly 
                485                 490                 495     


Ser Ala Ala Leu Pro Pro Glu Arg Gln Arg Glu Val Ala His Arg Tyr 
            500                 505                 510         


Val Leu Gly Leu Tyr Glu Ile Leu Glu Thr Leu Thr Ser Arg Phe Pro 
        515                 520                 525             


Asn Val Leu Phe Glu Asn Cys Ala Ser Gly Gly Gly Arg Phe Glu Leu 
    530                 535                 540                 


Gly Met Leu His Tyr Met Pro Gln Thr Trp Thr Ser Asp Asn Thr Asp 
545                 550                 555                 560 


Ala Val Ser Arg Leu Lys Ile Gln His Gly Thr Ser Leu Val Tyr Pro 
                565                 570                 575     


Pro Val Ala Met Gly Ala His Val Ser Ala Val Pro Asn His Gln Met 
            580                 585                 590         


Gly Arg Val Thr Pro Phe Ala Leu Arg Ala Gly Val Ala Met Cys Gly 
        595                 600                 605             


Asn Phe Gly Phe Glu Leu Asp Pro Arg Arg Leu Ser Asp Ala Glu Arg 
    610                 615                 620                 


Arg Glu Ala Arg Gln Ala Val Glu Arg Tyr Lys Ala Leu Arg His Leu 
625                 630                 635                 640 


Val Gln Phe Gly Asp Phe Tyr Arg Leu Leu Ser Pro Phe Asp Gly Pro 
                645                 650                 655     


Glu Ala Ala Trp Met Phe Ala Val Glu Asp Gly Ser Glu Ala Leu Val 
            660                 665                 670         


Ala Tyr Phe Cys Thr Tyr Pro Asp Pro Leu Asp Pro Pro Ala Arg Val 
        675                 680                 685             


Val Leu Arg Gly Leu Arg Pro Glu Ala Arg Tyr Arg Cys Glu Ala Leu 
    690                 695                 700                 


Gly Glu Ser Phe Arg Gly Asp Ala Leu Met Arg His Gly Leu Val Ile 
705                 710                 715                 720 


Pro Arg Gln Val Gly Asp Gly Gln Ala Val Leu Ile His Leu Lys Gln 
                725                 730                 735     


Ile Gly Glu Gly Asp Arg Pro 
            740             


<210>  197
<211>  743
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:185 and encoded by SEQ ID NO:192

<400>  197

Met Ala Ile Gly Lys Gly Arg Pro Ser Met Pro Ile Ile Phe His Ser 
1               5                   10                  15      


Asp Glu Arg Leu Phe His Leu Met Thr Pro Arg Ser Ser Tyr Leu Phe 
            20                  25                  30          


Arg Val Gly His Asp Gly Leu Leu Glu His Val Tyr Trp Gly Ala Arg 
        35                  40                  45              


Leu Glu Asp Ala Ser Asp Leu Val Arg Leu Ala Arg Ala Cys Gln Arg 
    50                  55                  60                  


Leu Asp Ala Arg Pro Glu His Met Arg Ala Ile Asp Ile Gly Ser Leu 
65                  70                  75                  80  


Arg Leu Glu Tyr Pro Ser Phe Gly Thr Gly Asp His Arg Asp Pro Ala 
                85                  90                  95      


Tyr Glu Val Leu Gln Pro Ser Gly Ser His Ala Ser Gln Leu Val Tyr 
            100                 105                 110         


Glu Ser His Gln Ile Arg Pro Gly Lys Pro Pro Leu Pro Gly Leu Pro 
        115                 120                 125             


Ala Phe Tyr Val Glu Ser Asp Phe Glu Ala Asp Thr Leu Glu Ile Ser 
    130                 135                 140                 


Leu Val Asp Pro Ala Ile Ser Leu Arg Val Ile Leu Ser Tyr Thr Ala 
145                 150                 155                 160 


Tyr Arg Asp Phe Asp Leu Val Cys Arg His Ala Arg Leu Glu Asn Ala 
                165                 170                 175     


Gly Thr Glu Pro Leu Val Leu Arg Arg Ala Leu Ser Ala Ser Val Asp 
            180                 185                 190         


Leu Asp Leu Arg Glu Ala Asp Phe Val Gln Leu Ser Gly Ala Trp Ile 
        195                 200                 205             


Arg Glu Arg Phe Ile Gln Arg Thr Pro Leu Ser Pro Gly Arg His Glu 
    210                 215                 220                 


Ile Met Ser Arg Ser Gly Ala Ser Gly His Lys His Asn Pro Phe Phe 
225                 230                 235                 240 


Ala Leu Ala Ala Pro His Thr Thr Glu Glu Gly Gly Glu Val Arg Ala 
                245                 250                 255     


Phe Ala Leu Val Tyr Ser Gly Asn Phe Leu Gly Ala Cys Glu Met Glu 
            260                 265                 270         


Pro Met Arg Gln Asn Val Arg Ala Gln Ile Gly Ile His Pro Ser Asp 
        275                 280                 285             


Phe Ser Trp Arg Leu Glu Pro Gly Glu Arg Phe Val Thr Pro Glu Ala 
    290                 295                 300                 


Ala Leu Val Tyr Ser Asp Glu Gly Trp Gly Gly Met Ser Arg Thr Phe 
305                 310                 315                 320 


His Arg Ala Ile Arg Lys Arg Leu Cys Arg Gly Thr Tyr Arg Asp Arg 
                325                 330                 335     


Val Arg Pro Val Leu Ile Asn Asn Trp Glu Ala Thr Tyr Phe His Phe 
            340                 345                 350         


Asp Glu Glu Asp Leu Val Glu Ile Ala Glu Gln Ala Arg Asp Leu Gly 
        355                 360                 365             


Ala Glu Met Phe Val Leu Asp Asp Gly Trp Phe Gly Gln Arg Asp Asp 
    370                 375                 380                 


Asp His Thr Ser Leu Gly Asp Trp Trp Pro His Pro Arg Lys Leu Pro 
385                 390                 395                 400 


Asn Gly Leu Arg His Leu Ala Asp Arg Ile His Ala Leu Gly Leu Arg 
                405                 410                 415     


Phe Gly Ile Trp Met Glu Pro Glu Met Val Ser Pro Lys Ser Glu Leu 
            420                 425                 430         


Tyr Arg Glu His Pro Asp Trp Cys Leu His Val Ala Asp Arg Pro Arg 
        435                 440                 445             


Ser Glu Arg Arg His Gln Leu Met Leu Asp Leu Thr Arg Glu Asp Val 
    450                 455                 460                 


Arg Ala Phe Val Val Asn Ala Val Ser Arg Val Ile Glu Glu Gly Ala 
465                 470                 475                 480 


Val Asp Tyr Ile Lys Trp Asp Met Asn Arg Pro Met Thr Glu Val Gly 
                485                 490                 495     


Ser Ala Ala Leu Pro Pro Glu Arg Gln Arg Glu Val Ala His Arg Tyr 
            500                 505                 510         


Val Leu Gly Leu Tyr Glu Ile Leu Glu Thr Leu Thr Ser Arg Phe Pro 
        515                 520                 525             


Asn Val Leu Phe Glu Asn Cys Ala Ser Gly Gly Gly Arg Phe Glu Leu 
    530                 535                 540                 


Gly Met Leu His Tyr Met Pro Gln Thr Trp Thr Ser Asp Asn Thr Asp 
545                 550                 555                 560 


Ala Val Ser Arg Leu Lys Ile Gln His Gly Thr Ser Leu Val Tyr Pro 
                565                 570                 575     


Pro Val Ala Met Gly Ala His Val Ser Ala Val Pro Asn His Gln Met 
            580                 585                 590         


Gly Arg Val Thr Pro Phe Ala Leu Arg Ala Gly Val Ala Met Cys Gly 
        595                 600                 605             


Asn Phe Gly Phe Glu Leu Asp Pro Arg Arg Leu Ser Asp Ala Glu Arg 
    610                 615                 620                 


Arg Glu Ala Arg Gln Ala Val Glu Arg Tyr Lys Ala Leu Arg His Leu 
625                 630                 635                 640 


Val Gln Phe Gly Asp Phe Tyr Arg Leu Leu Ser Pro Phe Asp Gly Pro 
                645                 650                 655     


Glu Ala Ala Trp Met Phe Ala Val Glu Asp Gly Ser Glu Ala Leu Val 
            660                 665                 670         


Ala Tyr Phe Cys Thr Tyr Pro Asp Pro Leu Asp Pro Pro Ala Arg Val 
        675                 680                 685             


Val Leu Arg Gly Leu Arg Pro Glu Ala Arg Tyr Arg Cys Glu Ala Leu 
    690                 695                 700                 


Gly Glu Ser Phe Arg Gly Asp Ala Leu Met Arg His Gly Leu Val Ile 
705                 710                 715                 720 


Pro Arg Gln Val Gly Asp Gly Gln Ala Val Leu Ile His Leu Lys Gln 
                725                 730                 735     


Ile Gly Glu Gly Asp Arg Pro 
            740             


<210>  198
<211>  743
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:185 and encoded by SEQ ID NO:193

<400>  198

Met Ala Ile Gly Lys Gly Arg Pro Ser Met Pro Ile Ile Phe His Ser 
1               5                   10                  15      


Asp Glu Arg Leu Phe His Leu Met Thr Pro Arg Ser Ser Tyr Val Phe 
            20                  25                  30          


Lys Val Gly His Asp Gly Leu Leu Glu His Val Tyr Trp Gly Ala Arg 
        35                  40                  45              


Leu Glu Asp Ala Ser Asp Leu Val Arg Leu Ala Arg Ala Cys Gln Arg 
    50                  55                  60                  


Leu Asp Ala Arg Pro Glu His Met Arg Ala Ile Asp Ile Gly Ser Leu 
65                  70                  75                  80  


Arg Leu Glu Tyr Pro Ser Phe Gly Thr Gly Asp His Arg Asp Pro Ala 
                85                  90                  95      


Tyr Glu Val Leu Gln Pro Ser Gly Ser His Ala Ser Gln Leu Val Tyr 
            100                 105                 110         


Glu Ser His Gln Ile Arg Pro Gly Lys Pro Pro Leu Pro Gly Leu Pro 
        115                 120                 125             


Ala Phe Tyr Val Glu Ser Asp Phe Glu Ala Asp Thr Leu Glu Ile Ser 
    130                 135                 140                 


Leu Val Asp Pro Ala Ile Ser Leu Arg Val Ile Leu Ser Tyr Thr Ala 
145                 150                 155                 160 


Tyr Arg Asp Phe Asp Leu Val Cys Arg His Ala Arg Leu Glu Asn Ala 
                165                 170                 175     


Gly Thr Glu Pro Leu Val Leu Arg Arg Ala Leu Ser Ala Ser Val Asp 
            180                 185                 190         


Leu Asp Leu Arg Glu Ala Asp Phe Val Gln Leu Ser Gly Ala Trp Ile 
        195                 200                 205             


Arg Glu Arg Phe Ile Gln Arg Thr Pro Leu Ser Pro Gly Arg His Glu 
    210                 215                 220                 


Ile Met Ser Arg Ser Gly Ala Ser Gly His Lys His Asn Pro Phe Phe 
225                 230                 235                 240 


Ala Leu Ala Ala Pro His Thr Thr Glu Glu Gly Gly Glu Val Arg Ala 
                245                 250                 255     


Phe Ala Leu Val Tyr Ser Gly Asn Phe Leu Gly Ala Cys Glu Met Glu 
            260                 265                 270         


Pro Met Arg Gln Asn Val Arg Ala Gln Ile Gly Ile His Pro Ser Asp 
        275                 280                 285             


Phe Ser Trp Arg Leu Glu Pro Gly Glu Arg Phe Val Thr Pro Glu Ala 
    290                 295                 300                 


Ala Leu Val Tyr Ser Asp Glu Gly Trp Gly Gly Met Ser Arg Thr Phe 
305                 310                 315                 320 


His Arg Ala Ile Arg Lys Arg Leu Cys Arg Gly Thr Tyr Arg Asp Arg 
                325                 330                 335     


Val Arg Pro Val Leu Ile Asn Asn Trp Glu Ala Thr Tyr Phe His Phe 
            340                 345                 350         


Asp Glu Glu Asp Leu Val Glu Ile Ala Glu Gln Ala Arg Asp Leu Gly 
        355                 360                 365             


Ala Glu Met Phe Val Leu Asp Asp Gly Trp Phe Gly Gln Arg Asp Asp 
    370                 375                 380                 


Asp His Thr Ser Leu Gly Asp Trp Trp Pro His Pro Arg Lys Leu Pro 
385                 390                 395                 400 


Asn Gly Leu Arg His Leu Ala Asp Arg Ile His Ala Leu Gly Leu Arg 
                405                 410                 415     


Phe Gly Ile Trp Met Glu Pro Glu Met Val Ser Pro Lys Ser Glu Leu 
            420                 425                 430         


Tyr Arg Glu His Pro Asp Trp Cys Leu His Val Ala Asp Arg Pro Arg 
        435                 440                 445             


Ser Glu Arg Arg His Gln Leu Met Leu Asp Leu Thr Arg Glu Asp Val 
    450                 455                 460                 


Arg Ala Phe Val Val Asn Ala Val Ser Arg Val Ile Glu Glu Gly Ala 
465                 470                 475                 480 


Val Asp Tyr Ile Lys Trp Asp Met Asn Arg Pro Met Thr Glu Val Gly 
                485                 490                 495     


Ser Ala Ala Leu Pro Pro Glu Arg Gln Arg Glu Val Ala His Arg Tyr 
            500                 505                 510         


Val Leu Gly Leu Tyr Glu Ile Leu Glu Thr Leu Thr Ser Arg Phe Pro 
        515                 520                 525             


Asn Val Leu Phe Glu Asn Cys Ala Ser Gly Gly Gly Arg Phe Glu Leu 
    530                 535                 540                 


Gly Met Leu His Tyr Met Pro Gln Thr Trp Thr Ser Asp Asn Thr Asp 
545                 550                 555                 560 


Ala Val Ser Arg Leu Lys Ile Gln His Gly Thr Ser Leu Val Tyr Pro 
                565                 570                 575     


Pro Val Ala Met Gly Ala His Val Ser Ala Val Pro Asn His Gln Met 
            580                 585                 590         


Gly Arg Val Thr Pro Phe Ala Leu Arg Ala Gly Val Ala Met Cys Gly 
        595                 600                 605             


Asn Phe Gly Phe Glu Leu Asp Pro Arg Arg Leu Ser Asp Ala Glu Arg 
    610                 615                 620                 


Arg Glu Ala Arg Gln Ala Val Glu Arg Tyr Lys Ala Leu Arg His Leu 
625                 630                 635                 640 


Val Gln Phe Gly Asp Phe Tyr Arg Leu Leu Ser Pro Phe Asp Gly Pro 
                645                 650                 655     


Glu Ala Ala Trp Met Phe Ala Val Glu Asp Gly Ser Glu Ala Leu Val 
            660                 665                 670         


Ala Tyr Phe Cys Thr Tyr Pro Asp Pro Leu Asp Pro Pro Ala Arg Val 
        675                 680                 685             


Val Leu Arg Gly Leu Arg Pro Glu Ala Arg Tyr Arg Cys Glu Ala Leu 
    690                 695                 700                 


Gly Glu Ser Phe Arg Gly Asp Ala Leu Met Arg His Gly Leu Val Ile 
705                 710                 715                 720 


Pro Arg Gln Val Gly Asp Gly Gln Ala Val Leu Ile His Leu Lys Gln 
                725                 730                 735     


Ile Gly Glu Gly Asp Arg Pro 
            740             


<210>  199
<211>  743
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:185 and encoded by SEQ ID NO:194

<400>  199

Met Ala Ile Gly Lys Gly Arg Pro Ser Met Pro Ile Ile Phe His Ser 
1               5                   10                  15      


Asp Glu Arg Leu Phe His Leu Met Thr Pro Arg Ser Ser Tyr Val Phe 
            20                  25                  30          


Arg Val Gly His Asp Gly Ile Leu Glu His Val Tyr Trp Gly Ala Arg 
        35                  40                  45              


Leu Glu Asp Ala Ser Asp Leu Val Arg Leu Ala Arg Ala Cys Gln Arg 
    50                  55                  60                  


Leu Asp Ala Arg Pro Glu His Met Arg Ala Ile Asp Ile Gly Ser Leu 
65                  70                  75                  80  


Arg Leu Glu Tyr Pro Ser Phe Gly Thr Gly Asp His Arg Asp Pro Ala 
                85                  90                  95      


Tyr Glu Val Leu Gln Pro Ser Gly Ser His Ala Ser Gln Leu Val Tyr 
            100                 105                 110         


Glu Ser His Gln Ile Arg Pro Gly Lys Pro Pro Leu Pro Gly Leu Pro 
        115                 120                 125             


Ala Phe Tyr Val Glu Ser Asp Phe Glu Ala Asp Thr Leu Glu Ile Ser 
    130                 135                 140                 


Leu Val Asp Pro Ala Ile Ser Leu Arg Val Ile Leu Ser Tyr Thr Ala 
145                 150                 155                 160 


Tyr Arg Asp Phe Asp Leu Val Cys Arg His Ala Arg Leu Glu Asn Ala 
                165                 170                 175     


Gly Thr Glu Pro Leu Val Leu Arg Arg Ala Leu Ser Ala Ser Val Asp 
            180                 185                 190         


Leu Asp Leu Arg Glu Ala Asp Phe Val Gln Leu Ser Gly Ala Trp Ile 
        195                 200                 205             


Arg Glu Arg Phe Ile Gln Arg Thr Pro Leu Ser Pro Gly Arg His Glu 
    210                 215                 220                 


Ile Met Ser Arg Ser Gly Ala Ser Gly His Lys His Asn Pro Phe Phe 
225                 230                 235                 240 


Ala Leu Ala Ala Pro His Thr Thr Glu Glu Gly Gly Glu Val Arg Ala 
                245                 250                 255     


Phe Ala Leu Val Tyr Ser Gly Asn Phe Leu Gly Ala Cys Glu Met Glu 
            260                 265                 270         


Pro Met Arg Gln Asn Val Arg Ala Gln Ile Gly Ile His Pro Ser Asp 
        275                 280                 285             


Phe Ser Trp Arg Leu Glu Pro Gly Glu Arg Phe Val Thr Pro Glu Ala 
    290                 295                 300                 


Ala Leu Val Tyr Ser Asp Glu Gly Trp Gly Gly Met Ser Arg Thr Phe 
305                 310                 315                 320 


His Arg Ala Ile Arg Lys Arg Leu Cys Arg Gly Thr Tyr Arg Asp Arg 
                325                 330                 335     


Val Arg Pro Val Leu Ile Asn Asn Trp Glu Ala Thr Tyr Phe His Phe 
            340                 345                 350         


Asp Glu Glu Asp Leu Val Glu Ile Ala Glu Gln Ala Arg Asp Leu Gly 
        355                 360                 365             


Ala Glu Met Phe Val Leu Asp Asp Gly Trp Phe Gly Gln Arg Asp Asp 
    370                 375                 380                 


Asp His Thr Ser Leu Gly Asp Trp Trp Pro His Pro Arg Lys Leu Pro 
385                 390                 395                 400 


Asn Gly Leu Arg His Leu Ala Asp Arg Ile His Ala Leu Gly Leu Arg 
                405                 410                 415     


Phe Gly Ile Trp Met Glu Pro Glu Met Val Ser Pro Lys Ser Glu Leu 
            420                 425                 430         


Tyr Arg Glu His Pro Asp Trp Cys Leu His Val Ala Asp Arg Pro Arg 
        435                 440                 445             


Ser Glu Arg Arg His Gln Leu Met Leu Asp Leu Thr Arg Glu Asp Val 
    450                 455                 460                 


Arg Ala Phe Val Val Asn Ala Val Ser Arg Val Ile Glu Glu Gly Ala 
465                 470                 475                 480 


Val Asp Tyr Ile Lys Trp Asp Met Asn Arg Pro Met Thr Glu Val Gly 
                485                 490                 495     


Ser Ala Ala Leu Pro Pro Glu Arg Gln Arg Glu Val Ala His Arg Tyr 
            500                 505                 510         


Val Leu Gly Leu Tyr Glu Ile Leu Glu Thr Leu Thr Ser Arg Phe Pro 
        515                 520                 525             


Asn Val Leu Phe Glu Asn Cys Ala Ser Gly Gly Gly Arg Phe Glu Leu 
    530                 535                 540                 


Gly Met Leu His Tyr Met Pro Gln Thr Trp Thr Ser Asp Asn Thr Asp 
545                 550                 555                 560 


Ala Val Ser Arg Leu Lys Ile Gln His Gly Thr Ser Leu Val Tyr Pro 
                565                 570                 575     


Pro Val Ala Met Gly Ala His Val Ser Ala Val Pro Asn His Gln Met 
            580                 585                 590         


Gly Arg Val Thr Pro Phe Ala Leu Arg Ala Gly Val Ala Met Cys Gly 
        595                 600                 605             


Asn Phe Gly Phe Glu Leu Asp Pro Arg Arg Leu Ser Asp Ala Glu Arg 
    610                 615                 620                 


Arg Glu Ala Arg Gln Ala Val Glu Arg Tyr Lys Ala Leu Arg His Leu 
625                 630                 635                 640 


Val Gln Phe Gly Asp Phe Tyr Arg Leu Leu Ser Pro Phe Asp Gly Pro 
                645                 650                 655     


Glu Ala Ala Trp Met Phe Ala Val Glu Asp Gly Ser Glu Ala Leu Val 
            660                 665                 670         


Ala Tyr Phe Cys Thr Tyr Pro Asp Pro Leu Asp Pro Pro Ala Arg Val 
        675                 680                 685             


Val Leu Arg Gly Leu Arg Pro Glu Ala Arg Tyr Arg Cys Glu Ala Leu 
    690                 695                 700                 


Gly Glu Ser Phe Arg Gly Asp Ala Leu Met Arg His Gly Leu Val Ile 
705                 710                 715                 720 


Pro Arg Gln Val Gly Asp Gly Gln Ala Val Leu Ile His Leu Lys Gln 
                725                 730                 735     


Ile Gly Glu Gly Asp Arg Pro 
            740             


<210>  200
<211>  743
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:185 and encoded by SEQ ID NO:195

<400>  200

Met Ala Ile Gly Lys Gly Arg Pro Ser Met Pro Ile Ile Phe His Ser 
1               5                   10                  15      


Gln Glu Arg Leu Phe His Leu Met Thr Pro Arg Ser Ser Tyr Val Phe 
            20                  25                  30          


Arg Val Gly His Asp Gly Leu Leu Glu His Val Tyr Trp Gly Ala Arg 
        35                  40                  45              


Leu Glu Asp Ala Ser Asp Leu Val Arg Leu Ala Arg Ala Cys Gln Arg 
    50                  55                  60                  


Leu Asp Ala Arg Pro Glu His Met Arg Ala Ile Asp Ile Gly Ser Leu 
65                  70                  75                  80  


Arg Leu Glu Tyr Pro Ser Phe Gly Thr Gly Asp His Arg Asp Pro Ala 
                85                  90                  95      


Tyr Glu Val Leu Gln Pro Ser Gly Ser His Ala Ser Gln Leu Val Tyr 
            100                 105                 110         


Glu Ser His Gln Ile Arg Pro Gly Lys Pro Pro Leu Pro Gly Leu Pro 
        115                 120                 125             


Ala Phe Tyr Val Glu Ser Asp Phe Glu Ala Asp Thr Leu Glu Ile Ser 
    130                 135                 140                 


Leu Val Asp Pro Ala Ile Ser Leu Arg Val Ile Leu Ser Tyr Thr Ala 
145                 150                 155                 160 


Tyr Arg Asp Phe Asp Leu Val Cys Arg His Ala Arg Leu Glu Asn Ala 
                165                 170                 175     


Gly Thr Glu Pro Leu Val Leu Arg Arg Ala Leu Ser Ala Ser Val Asp 
            180                 185                 190         


Leu Asp Leu Arg Glu Ala Asp Phe Val Gln Leu Ser Gly Ala Trp Ile 
        195                 200                 205             


Arg Glu Arg Phe Ile Gln Arg Thr Pro Leu Ser Pro Gly Arg His Glu 
    210                 215                 220                 


Ile Met Ser Arg Ser Gly Ala Ser Gly His Lys His Asn Pro Phe Phe 
225                 230                 235                 240 


Ala Leu Ala Ala Pro His Thr Thr Glu Glu Gly Gly Glu Val Arg Ala 
                245                 250                 255     


Phe Ala Leu Val Tyr Ser Gly Asn Phe Leu Gly Ala Cys Glu Met Glu 
            260                 265                 270         


Pro Met Arg Gln Asn Val Arg Ala Gln Ile Gly Ile His Pro Ser Asp 
        275                 280                 285             


Phe Ser Trp Arg Leu Glu Pro Gly Glu Arg Phe Val Thr Pro Glu Ala 
    290                 295                 300                 


Ala Leu Val Tyr Ser Asp Glu Gly Trp Gly Gly Met Ser Arg Thr Phe 
305                 310                 315                 320 


His Arg Ala Ile Arg Lys Arg Leu Cys Arg Gly Thr Tyr Arg Asp Arg 
                325                 330                 335     


Val Arg Pro Val Leu Ile Asn Asn Trp Glu Ala Thr Tyr Phe His Phe 
            340                 345                 350         


Asp Glu Glu Asp Leu Val Glu Ile Ala Glu Gln Ala Arg Asp Leu Gly 
        355                 360                 365             


Ala Glu Met Phe Val Leu Asp Asp Gly Trp Phe Gly Gln Arg Asp Asp 
    370                 375                 380                 


Asp His Thr Ser Leu Gly Asp Trp Trp Pro His Pro Arg Lys Leu Pro 
385                 390                 395                 400 


Asn Gly Leu Arg His Leu Ala Asp Arg Ile His Ala Leu Gly Leu Arg 
                405                 410                 415     


Phe Gly Ile Trp Met Glu Pro Glu Met Val Ser Pro Lys Ser Glu Leu 
            420                 425                 430         


Tyr Arg Glu His Pro Asp Trp Cys Leu His Val Ala Asp Arg Pro Arg 
        435                 440                 445             


Ser Glu Arg Arg His Gln Leu Met Leu Asp Leu Thr Arg Glu Asp Val 
    450                 455                 460                 


Arg Ala Phe Val Val Asn Ala Val Ser Arg Val Ile Glu Glu Gly Ala 
465                 470                 475                 480 


Val Asp Tyr Ile Lys Trp Asp Met Asn Arg Pro Met Thr Glu Val Gly 
                485                 490                 495     


Ser Ala Ala Leu Pro Pro Glu Arg Gln Arg Glu Val Ala His Arg Tyr 
            500                 505                 510         


Val Leu Gly Leu Tyr Glu Ile Leu Glu Thr Leu Thr Ser Arg Phe Pro 
        515                 520                 525             


Asn Val Leu Phe Glu Asn Cys Ala Ser Gly Gly Gly Arg Phe Glu Leu 
    530                 535                 540                 


Gly Met Leu His Tyr Met Pro Gln Thr Trp Thr Ser Asp Asn Thr Asp 
545                 550                 555                 560 


Ala Val Ser Arg Leu Lys Ile Gln His Gly Thr Ser Leu Val Tyr Pro 
                565                 570                 575     


Pro Val Ala Met Gly Ala His Val Ser Ala Val Pro Asn His Gln Met 
            580                 585                 590         


Gly Arg Val Thr Pro Phe Ala Leu Arg Ala Gly Val Ala Met Cys Gly 
        595                 600                 605             


Asn Phe Gly Phe Glu Leu Asp Pro Arg Arg Leu Ser Asp Ala Glu Arg 
    610                 615                 620                 


Arg Glu Ala Arg Gln Ala Val Glu Arg Tyr Lys Ala Leu Arg His Leu 
625                 630                 635                 640 


Val Gln Phe Gly Asp Phe Tyr Arg Leu Leu Ser Pro Phe Asp Gly Pro 
                645                 650                 655     


Glu Ala Ala Trp Met Phe Ala Val Glu Asp Gly Ser Glu Ala Leu Val 
            660                 665                 670         


Ala Tyr Phe Cys Thr Tyr Pro Asp Pro Leu Asp Pro Pro Ala Arg Val 
        675                 680                 685             


Val Leu Arg Gly Leu Arg Pro Glu Ala Arg Tyr Arg Cys Glu Ala Leu 
    690                 695                 700                 


Gly Glu Ser Phe Arg Gly Asp Ala Leu Met Arg His Gly Leu Val Ile 
705                 710                 715                 720 


Pro Arg Gln Val Gly Asp Gly Gln Ala Val Leu Ile His Leu Lys Gln 
                725                 730                 735     


Ile Gly Glu Gly Asp Arg Pro 
            740             


<210>  201
<211>  8151
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  201
atggcgttcg acacagagct cgagaggcgc gcgcatgcat tggcgctgac gcaagacatc     60

agttcgacgc gcggcggggg atccgacctg tggcccatct tgcgccgaaa ggcggcccgg    120

gtgcggaatc tcgccaccag gctcgagcga gagcctgcgg cgtgttctga gcccgcgcac    180

gagtggctga tcgatcacgc cgcctatctc gaactccagg cgatgttggc ggagcgcctg    240

tggccgaacg ccgtggtgcg gaaactgccg aggatggccg agaccgggga gccccgcgtg    300

gtgaccctcg ccgcggccta cctcgatgcg acgcgcggac acgtcgaagc cgagacgctc    360

atccggtttg tcgaggcgta ccaggacgtc caggttctga cgacgcacga gtgtcaccag    420

ctggccaacg gcctgcgcgt cgcgatcctc acgcggctcg ccgaagcgag cgatgagata    480

cagcatcggt acgagacgtg tcgcgcggtc ggccgcttgc tcgacgagat cgagcgggga    540

gacgggccag tggccgtgcg ccgcgccatc gaccgctttt ctaagggacg tgggcttggc    600

gccgtggagg tggtgcatct cgtgcatcac ctgtccgagt gggagccgga cagccaggag    660

ctgcgcgagt ggctggcggc gcacgtcgcc aactcttccg agagcatcga gcggctgacg    720

acgtacgagg ccgagtggca cgccgaaatc caggtgctca tcggcaatct ggtgcagagc    780

ctgcacgcgc tggagcgcat gtcctggcag cccatcgcct cgcgcatctc ccgggtggag    840

tcctgcctgc ggcaagaacc gacgggcgac tacctgcggc tcgatccgac gagccagaac    900

gtgctcacgc agcaggtcag ctggctcagc gaggccttcc gcctgcccga ggcgatgatc    960

gccgagaccg ccgtctcgtt ggcgcgagag gcctgggaga aggccggatc gcccaccgcc   1020

tcgagcgacc tgccgcggga ggcgtttgtc gcgtactatc tgtgcgatcc cgacgggatg   1080

cacgcgcttc accgatcgct caaggagcgc gcgaagccga gatcagttcc gcagattgca   1140

cttcgccgcc gtccccttcg ttcgtacctc cttggtgtgg cgtttctgtt cgcggccatc   1200

ctgtgggcgg tgctcggggg gttcacgggc ggatttcgcg cgccccttgg ggcgacgctg   1260

gcgcttgccg tcctgctcgc gcttcccgtc agcgaatggg tcatttcgct cgtgcacgag   1320

gggatacgcc gcgccgttcg gcctgtgcct ctcctgcgcc tcgacttcag cgaggggatt   1380

ccggaggacg cgcgcaccct gatcgtgctc cccgtcattt gggcgagcga ggccgacgtc   1440

gacgaggcgt ttgacaagat cgagcttcac cacctgacga accgcggggc ccatctctac   1500

ttcgcggtgc tctcggacct ccgggacgcc gacgcgccgc acctgccgga ggacgagcct   1560

ttgctcgccc gggcgcgcgc gcgcctggag gcgctgcggc acaagtacgg agccgctcgc   1620

ttcttttggt tccaccgcga tcgcgtcctc aaccgcgcgg acggcgtcta catgggctgg   1680

gagcgaaagc gaggcaagct ggtggagttt gtcgagctgc ttcgcggcaa gcgcgacacg   1740

accttccgcg tgaaagacgg cgatctcgcc gtgctgccga cgattcgcta cgtgttcacc   1800

gcggatctcg acaccgaact gcccattggc accgtgcagc gccttgtcgg caccatgcac   1860

ctgccataca accggccgcg gctcaacgcc cgtggcacgc gggtggacca gggctacggc   1920

gtgctccagc cggccgtcgc cgtcagcccg cgctcgaccc aggcctcccg attcgcgcgc   1980

ctctggtcgg gcgagacggg cgtggatccg tacgcgttcg ccatctccaa cccttatcag   2040

gattggttcg ggcgcggcct gttcgtcggc aaggggctta tccacgtcga cgcgtttcac   2100

accgtgctgt gcgatcgcat cccggacaac cgggtcttaa gccacgacat cctcgaaggc   2160

gggtttttgc gcgccggcct cgtggcggac gtggaggtgg tcgagagcca gccggcgacg   2220

ctgcgcgcct acatgcgccg cgcccatcgg tgggtgcgtg gagactggca gctgacgtat   2280

tggttgcgcc gggtgtgtcg cgatcggcgc ggggagacgc agcctgtgga tttgtgcggc   2340

ttcacgcgct ggaacatcgt cgatcacgtc cggcacagcc tggtcaaccc cgcgctcgtc   2400

ctgctcatgg gctccggcat gtcagggctt ttgcccggcc cagcgtacgc atacggcgcc   2460

gtgctcctta tcaccgtgtt tttgcccttt ttgcgccagc ttgagtccat ccggcccggc   2520

gaatgggact ggaggagcgc cgcgacggcg cttggccaga gcctggtcat gctcgtgacg   2580

ctgccgttca tggcggtggt cgaggcggac gccagcctgc gcgctctgta tcggatgctc   2640

gtcagccgac ggcggctgct cgagtggatc ccctcctctc acgcggaccg gtcggacgga   2700

tcgcccgcgc ctcttctcta cgagccggcg ggttacgcgg tcgcgctggc gtgttcggtg   2760

cctgggctct tcggcacgtg ggaacaggcg ctctcgagca ccctcgcgct cgcggtgtgg   2820

ctgccggcgc acgccgtggc acgctttctg gcgaagcccg cgggagaagc gcgcgtcgcg   2880

gcgcccgatc ctgcactctc cgcgcacctg cgcgaggtgg ccacggcgat gtggcggttt   2940

tacgagcggt acgtcggcga agaagatcat cacctgccgc cggacaacgt gcagtttgag   3000

cccgtggagc ggatcgcgca ccgcacgtcg ccgaccaaca tcgggctcta tctcttgtgc   3060

gtcgccgcgg cggcggatct cgagatcatc ccgaaggaag gcgccatcgc ccgcctcgag   3120

cgaaccctgg cgacgctcac gtccctggat cgatggcatg ggcacctgtt caactggtac   3180

gacacgcgca cgctcaggcc cctcgcgccg aggtacgtct cgaccgtgga ctctggcaat   3240

ctggtctgcg cgatgctcgc cttggggcag gccctgcgcg aatgggcggc atccgacgcg   3300

gacatcgccc ctcgcgcgcg ccgccttgcg gacgcgatgg agggcttcgc gcgggagatc   3360

gattttcgtc ctttgtatcg cccggatctc aggctttttt cgttgggctt tcacgcggat   3420

cgaaacgagc tcgagaacat cgtctacgat ctcctcgcct ccgaggcgcg ccaggcaagc   3480

ttcatcgcca ttgcgagcgg ccaggtgccc gcgtcgcact ggttcgcgct gtcccgcacc   3540

atgacgcgcg cgggccggta ccagccgctt ttgtcctggt ccgggacgat gttcgaatat   3600

ctcatgcccg cgctcctgat gcgccatctc cctcacacgc tgtgggagga gacctaccgt   3660

ggtgtcgtgt ggagacagat cgcctacgcg cgagagcgcg gcgtcccgtt cggcatctcg   3720

gagagcggct tctacgcgtt cgatcgcgac ctcaactacc aataccgggc gtttggcgtg   3780

ccggggctcg ggctggaccg cggcctggag caacacctcg tggtggcgcc gtatgcgacc   3840

atgctggcgc ttcccttcgc ccctgaacag gtggccgagg cgctccggca attgcgggaa   3900

cttggagcgc tgggaccgta cggctattac gaggccgtcg acttcacggc gagccggctt   3960

ccgccgggag accggtacaa ggtggtgcag agcttcatgg cgcaccacca gggcatggcg   4020

ttcatcgcca tcgccaacta cctgaatcgc aacctttggg tggagcggtt ccatcgcctg   4080

ccgctggtgc gcgcggccga gtacatgctg tacgagcgta tgccgaagcg gcccgcgctg   4140

ctcctcaagc cggttcacgc cgcgcacgcg cccaacttcg atcgcccggt ctacgcgcgc   4200

cggcgaagtg gagacgatgt ggcctggaac gcggtctcca acggcagcct gacgagtttc   4260

gctgacgcgc gcggcgaggg cgggatcgcc tggcgcggca tcgcggtgac gcgctaccgg   4320

ccggatcggc acctgcccta tcgcggaccg gtcatgtacg tgcgagatgt cgatcgcggc   4380

ggcgtctttc gcaccaccct gcacggtggc ggcggacacg tagaggcgga gtttcgcccg   4440

gacaagtcga gttggaagcg cgtggtggac gggatcgaga gcgagtggtc ggtcctcgtg   4500

gccccggatc gagacgtgga gattcggacg ttggtccttc agaacctcgg ggaggacgtt   4560

cgccggctcg aggtgaccta tttcgccgaa ctcgcgcttg cgaagccggc tgcggacatc   4620

gcgcatccgt cgtttcagcg cctgttcgtc gagacgggat gggacgatgc gcgccaggtg   4680

ctgtgggccc agcgcaggcc cgagtcggac gatcagccag acgtgtacgc ggcgtttcac   4740

ctcgtcgcag acgaggaagc gccagcgccg gtggagtggg actcccatcg ggcgcggttc   4800

gtcggccgcg gcggcagcct cgcggcgccg cgggggctct ggcgccgtct gcgtggcgaa   4860

ggggtggccg atccggccgc gattctccgc acggccgtga ccctcgcacc cggggaaaag   4920

cgcgcgctct atgtcatcac cgcgctcggc gaggcgcggg acgaggtcgt ggagacggcg   4980

tttgaaatgc gccagccttc ggcccgatcg cgcgcggcgc agctcgcgtg gatgcgcgcg   5040

cagatcgatc tccgccagct gcacctttcg ccggacgatg tcgaggacgc catggaactt   5100

ctgtcgcggt tcttgtcccg gcacgcgttt tcgcccgagc ggcgggcggc cattctgcag   5160

aacgagcttg gccaatccgg gctctgggcg cacgggattt ccggcgatcg acccatcgtc   5220

gccgtccggc tcgcctccgc ggcggaggtc ccgtttgtcg cgaagctcgc gcggctcacg   5280

cagtatcttg cgcacatggg cttcgcgagc gatctcgtcg tgatcgacga gacgatatcc   5340

agctatcgag acgagatgcg ggatcggatc cgggcggaga tggcgcgccg cggcgtgcac   5400

gacgcggcga ccctcgccgt ggtgaaggcg gatcagcttt cgagcgccga gcgggcgctc   5460

atggaatcgg tggctgtcgc gacgttgcgg gccggtgggc cgagcgtcgg cgcgcagctc   5520

acgggcggac gggtgcggcg cgaggaatcg gcgagactcg cgtcggaccg cctggagccg   5580

gagccgaaac gcgcgccgcg cgatgcgggg caggtggagg gagagtttgc gaacggctat   5640

ggcgcgttcg tcgacgacgg tcgcgcgtac cgcatgcgtg tgacgcgcgc caagcggccc   5700

ccgcggccct ggtcgaacgt gcttgccaat cccaacttcg gcgcgctcgt gactgagctc   5760

ggcaccggct acacctggtg gcgcaacagc cgcgagttca agctcacgcc ctggcacaac   5820

gatgccgcct tcgacccgcc cggcgaggcc gtgtacatcg ccgatctcga ccgcggaatc   5880

atcgcgagcg ccaccccttc gcccgccggc gatgaacgga cgtacgacgt gacgcatcgg   5940

cccggcgtca ccacgtttga aagcgacgtg gagggcgtcc gcgtcacgct tcatgtgttc   6000

gtcgattctg ccgagcccgc gaagtggatg cgggtgcggc ttcgcaacca aagcggggag   6060

gagcgcagaa tccgcgtggc cccgtatgcc gaatgggtgc tcggcgtgga tccgttctcg   6120

aacacgcccc tcgtcgtggt gcggaagatg ggcgaagcgg atgccatcgc tgcggaaaac   6180

cggtatcagg aggcgtttcg cggcgccttg ggctttctgg ccgtgggcgg cgccggacgg   6240

acaacggggt ggttgggaga caagacgcgc ttcctcggcg acggatcgta tgctcggccc   6300

gacgcgctgc tcgaggacgc gtggcgcggg ggagacggcc ccacgccgac gccctgcgcc   6360

gtccttgcgc gcgatctcga ccttgggccg catgaggagg ccgaggtggt catcctcctt   6420

ggcgcggcgc ctgacgaaca cgaggccgcg aggctcgccc ggctcgccga cccggccgcg   6480

gcggatcgcg cgcttcgcga ggtcactaga ttctgggatg atcttcttgg gcgtgtccaa   6540

atccgcacac cggatcgcgc cttcgacatc ctgatgaacg gctggctcgt gtaccaggcc   6600

ctcgcctgcc gcctctgggc ccgcacggcc ttttaccagg ccggcggcgc gttcggcttt   6660

cgcgatcagc tgcaggacgc cctcgcgctg attcacgctc gacccgacat cctgcgcgat   6720

cagatcctgc gggcggcgcg ccatcagtac gtcgagggcg acgtgcagca ctggtggcat   6780

gaggagttgg gcaaaggcat ccgcacgcgc ttttcggacg atttgctttg gcttccgtac   6840

gcggtctcgc gttacctcga ggcgacgggc gatgccgcgc tcctcgatga acgcgcgccg   6900

tatctcgtga gcgccccgct tggcgacggc gaactcgagc gatacgagga cagcgtctgg   6960

agccaggagg aaggcaccct cgcggaacac gtcgcgcggg ctgtggagcg cgcgcttcac   7020

ttcggcgatc acggcctccc gctcatcggc atcggcgact ggaacgacgg cctgagccga   7080

gtcggcgcca agggccgggg cgagagcgtg tggctggcgt ggtttttggc ggatgtggtg   7140

cggcgggtgg ccgagatcga ccatccggag ttcgcgcaac accgtgcgcg ctggcttgcg   7200

atgcgcgagc gggttctcgc ggcggcgaac gagtcggcgt gggatggaca gtggtaccgg   7260

cgcgccatca cggacgatgg gctgtggctg ggatcggccg cctcgcccgc gtgccgggtg   7320

gacgccatcg cgcagtcgtg ggcggtcatc tcgggaggag ctccgccgga tcgggccgtg   7380

cgcgccatgg agtcgttcga tcgggaactc gtggaccggc ggctcggtgt ggctcatctc   7440

ctccagccag catttcgaga tctgcgcccg agtcctggct acatccaagg ctatccgccg   7500

ggaatccgcg agaacggtgg gcagtacaca cacggggtca tctggagtgt catcgcgtgg   7560

acgcggcttg ggagggcaga cgaggcgtat gaactgttct ccatgctgaa cccgattcat   7620

cacgccgaca cgccgcgcga agtggagcgg tacgggaacg aaccgtatgt gatgtcggcg   7680

gacgtctaca cggcggaacc gaacgtgggg cagggcggct ggtcctggta cacaggcgcc   7740

gcctcgtgga tgtaccaggc gggactggag gccatcctcg gcatacggag gcatgggacg   7800

aggttgctcg tggagccgtg cgtccccgcg cattggcctg gctttgaggt ggcgtatcgg   7860

tacggttcaa cgctgtaccg cattcgcgtg gagcgagcgc cacaaggcgc ggaggcgcgc   7920

gacagcgcgc tcacagtgga aggcgtggct ccggccgaga tcgatctcgt cgacgatggt   7980

caggaacacc acgtggttgt gtggctcgcg gccgaagggg ctgaggtctt aagcgatgtt   8040

cagacggtgg cggctaggcc gcgcgagggc gcccggcggt accgcatgtc gagcggcgcg   8100

cgcgcgttcc ccgcgagcgc ggcgtaccga aagcgcgacc cacaaccgta a            8151


<210>  202
<211>  2716
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  202

Met Ala Phe Asp Thr Glu Leu Glu Arg Arg Ala His Ala Leu Ala Leu 
1               5                   10                  15      


Thr Gln Asp Ile Ser Ser Thr Arg Gly Gly Gly Ser Asp Leu Trp Pro 
            20                  25                  30          


Ile Leu Arg Arg Lys Ala Ala Arg Val Arg Asn Leu Ala Thr Arg Leu 
        35                  40                  45              


Glu Arg Glu Pro Ala Ala Cys Ser Glu Pro Ala His Glu Trp Leu Ile 
    50                  55                  60                  


Asp His Ala Ala Tyr Leu Glu Leu Gln Ala Met Leu Ala Glu Arg Leu 
65                  70                  75                  80  


Trp Pro Asn Ala Val Val Arg Lys Leu Pro Arg Met Ala Glu Thr Gly 
                85                  90                  95      


Glu Pro Arg Val Val Thr Leu Ala Ala Ala Tyr Leu Asp Ala Thr Arg 
            100                 105                 110         


Gly His Val Glu Ala Glu Thr Leu Ile Arg Phe Val Glu Ala Tyr Gln 
        115                 120                 125             


Asp Val Gln Val Leu Thr Thr His Glu Cys His Gln Leu Ala Asn Gly 
    130                 135                 140                 


Leu Arg Val Ala Ile Leu Thr Arg Leu Ala Glu Ala Ser Asp Glu Ile 
145                 150                 155                 160 


Gln His Arg Tyr Glu Thr Cys Arg Ala Val Gly Arg Leu Leu Asp Glu 
                165                 170                 175     


Ile Glu Arg Gly Asp Gly Pro Val Ala Val Arg Arg Ala Ile Asp Arg 
            180                 185                 190         


Phe Ser Lys Gly Arg Gly Leu Gly Ala Val Glu Val Val His Leu Val 
        195                 200                 205             


His His Leu Ser Glu Trp Glu Pro Asp Ser Gln Glu Leu Arg Glu Trp 
    210                 215                 220                 


Leu Ala Ala His Val Ala Asn Ser Ser Glu Ser Ile Glu Arg Leu Thr 
225                 230                 235                 240 


Thr Tyr Glu Ala Glu Trp His Ala Glu Ile Gln Val Leu Ile Gly Asn 
                245                 250                 255     


Leu Val Gln Ser Leu His Ala Leu Glu Arg Met Ser Trp Gln Pro Ile 
            260                 265                 270         


Ala Ser Arg Ile Ser Arg Val Glu Ser Cys Leu Arg Gln Glu Pro Thr 
        275                 280                 285             


Gly Asp Tyr Leu Arg Leu Asp Pro Thr Ser Gln Asn Val Leu Thr Gln 
    290                 295                 300                 


Gln Val Ser Trp Leu Ser Glu Ala Phe Arg Leu Pro Glu Ala Met Ile 
305                 310                 315                 320 


Ala Glu Thr Ala Val Ser Leu Ala Arg Glu Ala Trp Glu Lys Ala Gly 
                325                 330                 335     


Ser Pro Thr Ala Ser Ser Asp Leu Pro Arg Glu Ala Phe Val Ala Tyr 
            340                 345                 350         


Tyr Leu Cys Asp Pro Asp Gly Met His Ala Leu His Arg Ser Leu Lys 
        355                 360                 365             


Glu Arg Ala Lys Pro Arg Ser Val Pro Gln Ile Ala Leu Arg Arg Arg 
    370                 375                 380                 


Pro Leu Arg Ser Tyr Leu Leu Gly Val Ala Phe Leu Phe Ala Ala Ile 
385                 390                 395                 400 


Leu Trp Ala Val Leu Gly Gly Phe Thr Gly Gly Phe Arg Ala Pro Leu 
                405                 410                 415     


Gly Ala Thr Leu Ala Leu Ala Val Leu Leu Ala Leu Pro Val Ser Glu 
            420                 425                 430         


Trp Val Ile Ser Leu Val His Glu Gly Ile Arg Arg Ala Val Arg Pro 
        435                 440                 445             


Val Pro Leu Leu Arg Leu Asp Phe Ser Glu Gly Ile Pro Glu Asp Ala 
    450                 455                 460                 


Arg Thr Leu Ile Val Leu Pro Val Ile Trp Ala Ser Glu Ala Asp Val 
465                 470                 475                 480 


Asp Glu Ala Phe Asp Lys Ile Glu Leu His His Leu Thr Asn Arg Gly 
                485                 490                 495     


Ala His Leu Tyr Phe Ala Val Leu Ser Asp Leu Arg Asp Ala Asp Ala 
            500                 505                 510         


Pro His Leu Pro Glu Asp Glu Pro Leu Leu Ala Arg Ala Arg Ala Arg 
        515                 520                 525             


Leu Glu Ala Leu Arg His Lys Tyr Gly Ala Ala Arg Phe Phe Trp Phe 
    530                 535                 540                 


His Arg Asp Arg Val Leu Asn Arg Ala Asp Gly Val Tyr Met Gly Trp 
545                 550                 555                 560 


Glu Arg Lys Arg Gly Lys Leu Val Glu Phe Val Glu Leu Leu Arg Gly 
                565                 570                 575     


Lys Arg Asp Thr Thr Phe Arg Val Lys Asp Gly Asp Leu Ala Val Leu 
            580                 585                 590         


Pro Thr Ile Arg Tyr Val Phe Thr Ala Asp Leu Asp Thr Glu Leu Pro 
        595                 600                 605             


Ile Gly Thr Val Gln Arg Leu Val Gly Thr Met His Leu Pro Tyr Asn 
    610                 615                 620                 


Arg Pro Arg Leu Asn Ala Arg Gly Thr Arg Val Asp Gln Gly Tyr Gly 
625                 630                 635                 640 


Val Leu Gln Pro Ala Val Ala Val Ser Pro Arg Ser Thr Gln Ala Ser 
                645                 650                 655     


Arg Phe Ala Arg Leu Trp Ser Gly Glu Thr Gly Val Asp Pro Tyr Ala 
            660                 665                 670         


Phe Ala Ile Ser Asn Pro Tyr Gln Asp Trp Phe Gly Arg Gly Leu Phe 
        675                 680                 685             


Val Gly Lys Gly Leu Ile His Val Asp Ala Phe His Thr Val Leu Cys 
    690                 695                 700                 


Asp Arg Ile Pro Asp Asn Arg Val Leu Ser His Asp Ile Leu Glu Gly 
705                 710                 715                 720 


Gly Phe Leu Arg Ala Gly Leu Val Ala Asp Val Glu Val Val Glu Ser 
                725                 730                 735     


Gln Pro Ala Thr Leu Arg Ala Tyr Met Arg Arg Ala His Arg Trp Val 
            740                 745                 750         


Arg Gly Asp Trp Gln Leu Thr Tyr Trp Leu Arg Arg Val Cys Arg Asp 
        755                 760                 765             


Arg Arg Gly Glu Thr Gln Pro Val Asp Leu Cys Gly Phe Thr Arg Trp 
    770                 775                 780                 


Asn Ile Val Asp His Val Arg His Ser Leu Val Asn Pro Ala Leu Val 
785                 790                 795                 800 


Leu Leu Met Gly Ser Gly Met Ser Gly Leu Leu Pro Gly Pro Ala Tyr 
                805                 810                 815     


Ala Tyr Gly Ala Val Leu Leu Ile Thr Val Phe Leu Pro Phe Leu Arg 
            820                 825                 830         


Gln Leu Glu Ser Ile Arg Pro Gly Glu Trp Asp Trp Arg Ser Ala Ala 
        835                 840                 845             


Thr Ala Leu Gly Gln Ser Leu Val Met Leu Val Thr Leu Pro Phe Met 
    850                 855                 860                 


Ala Val Val Glu Ala Asp Ala Ser Leu Arg Ala Leu Tyr Arg Met Leu 
865                 870                 875                 880 


Val Ser Arg Arg Arg Leu Leu Glu Trp Ile Pro Ser Ser His Ala Asp 
                885                 890                 895     


Arg Ser Asp Gly Ser Pro Ala Pro Leu Leu Tyr Glu Pro Ala Gly Tyr 
            900                 905                 910         


Ala Val Ala Leu Ala Cys Ser Val Pro Gly Leu Phe Gly Thr Trp Glu 
        915                 920                 925             


Gln Ala Leu Ser Ser Thr Leu Ala Leu Ala Val Trp Leu Pro Ala His 
    930                 935                 940                 


Ala Val Ala Arg Phe Leu Ala Lys Pro Ala Gly Glu Ala Arg Val Ala 
945                 950                 955                 960 


Ala Pro Asp Pro Ala Leu Ser Ala His Leu Arg Glu Val Ala Thr Ala 
                965                 970                 975     


Met Trp Arg Phe Tyr Glu Arg Tyr Val Gly Glu Glu Asp His His Leu 
            980                 985                 990         


Pro Pro Asp Asn Val Gln Phe Glu  Pro Val Glu Arg Ile  Ala His Arg 
        995                 1000                 1005             


Thr Ser  Pro Thr Asn Ile Gly  Leu Tyr Leu Leu Cys  Val Ala Ala 
    1010                 1015                 1020             


Ala Ala  Asp Leu Glu Ile Ile  Pro Lys Glu Gly Ala  Ile Ala Arg 
    1025                 1030                 1035             


Leu Glu  Arg Thr Leu Ala Thr  Leu Thr Ser Leu Asp  Arg Trp His 
    1040                 1045                 1050             


Gly His  Leu Phe Asn Trp Tyr  Asp Thr Arg Thr Leu  Arg Pro Leu 
    1055                 1060                 1065             


Ala Pro  Arg Tyr Val Ser Thr  Val Asp Ser Gly Asn  Leu Val Cys 
    1070                 1075                 1080             


Ala Met  Leu Ala Leu Gly Gln  Ala Leu Arg Glu Trp  Ala Ala Ser 
    1085                 1090                 1095             


Asp Ala  Asp Ile Ala Pro Arg  Ala Arg Arg Leu Ala  Asp Ala Met 
    1100                 1105                 1110             


Glu Gly  Phe Ala Arg Glu Ile  Asp Phe Arg Pro Leu  Tyr Arg Pro 
    1115                 1120                 1125             


Asp Leu  Arg Leu Phe Ser Leu  Gly Phe His Ala Asp  Arg Asn Glu 
    1130                 1135                 1140             


Leu Glu  Asn Ile Val Tyr Asp  Leu Leu Ala Ser Glu  Ala Arg Gln 
    1145                 1150                 1155             


Ala Ser  Phe Ile Ala Ile Ala  Ser Gly Gln Val Pro  Ala Ser His 
    1160                 1165                 1170             


Trp Phe  Ala Leu Ser Arg Thr  Met Thr Arg Ala Gly  Arg Tyr Gln 
    1175                 1180                 1185             


Pro Leu  Leu Ser Trp Ser Gly  Thr Met Phe Glu Tyr  Leu Met Pro 
    1190                 1195                 1200             


Ala Leu  Leu Met Arg His Leu  Pro His Thr Leu Trp  Glu Glu Thr 
    1205                 1210                 1215             


Tyr Arg  Gly Val Val Trp Arg  Gln Ile Ala Tyr Ala  Arg Glu Arg 
    1220                 1225                 1230             


Gly Val  Pro Phe Gly Ile Ser  Glu Ser Gly Phe Tyr  Ala Phe Asp 
    1235                 1240                 1245             


Arg Asp  Leu Asn Tyr Gln Tyr  Arg Ala Phe Gly Val  Pro Gly Leu 
    1250                 1255                 1260             


Gly Leu  Asp Arg Gly Leu Glu  Gln His Leu Val Val  Ala Pro Tyr 
    1265                 1270                 1275             


Ala Thr  Met Leu Ala Leu Pro  Phe Ala Pro Glu Gln  Val Ala Glu 
    1280                 1285                 1290             


Ala Leu  Arg Gln Leu Arg Glu  Leu Gly Ala Leu Gly  Pro Tyr Gly 
    1295                 1300                 1305             


Tyr Tyr  Glu Ala Val Asp Phe  Thr Ala Ser Arg Leu  Pro Pro Gly 
    1310                 1315                 1320             


Asp Arg  Tyr Lys Val Val Gln  Ser Phe Met Ala His  His Gln Gly 
    1325                 1330                 1335             


Met Ala  Phe Ile Ala Ile Ala  Asn Tyr Leu Asn Arg  Asn Leu Trp 
    1340                 1345                 1350             


Val Glu  Arg Phe His Arg Leu  Pro Leu Val Arg Ala  Ala Glu Tyr 
    1355                 1360                 1365             


Met Leu  Tyr Glu Arg Met Pro  Lys Arg Pro Ala Leu  Leu Leu Lys 
    1370                 1375                 1380             


Pro Val  His Ala Ala His Ala  Pro Asn Phe Asp Arg  Pro Val Tyr 
    1385                 1390                 1395             


Ala Arg  Arg Arg Ser Gly Asp  Asp Val Ala Trp Asn  Ala Val Ser 
    1400                 1405                 1410             


Asn Gly  Ser Leu Thr Ser Phe  Ala Asp Ala Arg Gly  Glu Gly Gly 
    1415                 1420                 1425             


Ile Ala  Trp Arg Gly Ile Ala  Val Thr Arg Tyr Arg  Pro Asp Arg 
    1430                 1435                 1440             


His Leu  Pro Tyr Arg Gly Pro  Val Met Tyr Val Arg  Asp Val Asp 
    1445                 1450                 1455             


Arg Gly  Gly Val Phe Arg Thr  Thr Leu His Gly Gly  Gly Gly His 
    1460                 1465                 1470             


Val Glu  Ala Glu Phe Arg Pro  Asp Lys Ser Ser Trp  Lys Arg Val 
    1475                 1480                 1485             


Val Asp  Gly Ile Glu Ser Glu  Trp Ser Val Leu Val  Ala Pro Asp 
    1490                 1495                 1500             


Arg Asp  Val Glu Ile Arg Thr  Leu Val Leu Gln Asn  Leu Gly Glu 
    1505                 1510                 1515             


Asp Val  Arg Arg Leu Glu Val  Thr Tyr Phe Ala Glu  Leu Ala Leu 
    1520                 1525                 1530             


Ala Lys  Pro Ala Ala Asp Ile  Ala His Pro Ser Phe  Gln Arg Leu 
    1535                 1540                 1545             


Phe Val  Glu Thr Gly Trp Asp  Asp Ala Arg Gln Val  Leu Trp Ala 
    1550                 1555                 1560             


Gln Arg  Arg Pro Glu Ser Asp  Asp Gln Pro Asp Val  Tyr Ala Ala 
    1565                 1570                 1575             


Phe His  Leu Val Ala Asp Glu  Glu Ala Pro Ala Pro  Val Glu Trp 
    1580                 1585                 1590             


Asp Ser  His Arg Ala Arg Phe  Val Gly Arg Gly Gly  Ser Leu Ala 
    1595                 1600                 1605             


Ala Pro  Arg Gly Leu Trp Arg  Arg Leu Arg Gly Glu  Gly Val Ala 
    1610                 1615                 1620             


Asp Pro  Ala Ala Ile Leu Arg  Thr Ala Val Thr Leu  Ala Pro Gly 
    1625                 1630                 1635             


Glu Lys  Arg Ala Leu Tyr Val  Ile Thr Ala Leu Gly  Glu Ala Arg 
    1640                 1645                 1650             


Asp Glu  Val Val Glu Thr Ala  Phe Glu Met Arg Gln  Pro Ser Ala 
    1655                 1660                 1665             


Arg Ser  Arg Ala Ala Gln Leu  Ala Trp Met Arg Ala  Gln Ile Asp 
    1670                 1675                 1680             


Leu Arg  Gln Leu His Leu Ser  Pro Asp Asp Val Glu  Asp Ala Met 
    1685                 1690                 1695             


Glu Leu  Leu Ser Arg Phe Leu  Ser Arg His Ala Phe  Ser Pro Glu 
    1700                 1705                 1710             


Arg Arg  Ala Ala Ile Leu Gln  Asn Glu Leu Gly Gln  Ser Gly Leu 
    1715                 1720                 1725             


Trp Ala  His Gly Ile Ser Gly  Asp Arg Pro Ile Val  Ala Val Arg 
    1730                 1735                 1740             


Leu Ala  Ser Ala Ala Glu Val  Pro Phe Val Ala Lys  Leu Ala Arg 
    1745                 1750                 1755             


Leu Thr  Gln Tyr Leu Ala His  Met Gly Phe Ala Ser  Asp Leu Val 
    1760                 1765                 1770             


Val Ile  Asp Glu Thr Ile Ser  Ser Tyr Arg Asp Glu  Met Arg Asp 
    1775                 1780                 1785             


Arg Ile  Arg Ala Glu Met Ala  Arg Arg Gly Val His  Asp Ala Ala 
    1790                 1795                 1800             


Thr Leu  Ala Val Val Lys Ala  Asp Gln Leu Ser Ser  Ala Glu Arg 
    1805                 1810                 1815             


Ala Leu  Met Glu Ser Val Ala  Val Ala Thr Leu Arg  Ala Gly Gly 
    1820                 1825                 1830             


Pro Ser  Val Gly Ala Gln Leu  Thr Gly Gly Arg Val  Arg Arg Glu 
    1835                 1840                 1845             


Glu Ser  Ala Arg Leu Ala Ser  Asp Arg Leu Glu Pro  Glu Pro Lys 
    1850                 1855                 1860             


Arg Ala  Pro Arg Asp Ala Gly  Gln Val Glu Gly Glu  Phe Ala Asn 
    1865                 1870                 1875             


Gly Tyr  Gly Ala Phe Val Asp  Asp Gly Arg Ala Tyr  Arg Met Arg 
    1880                 1885                 1890             


Val Thr  Arg Ala Lys Arg Pro  Pro Arg Pro Trp Ser  Asn Val Leu 
    1895                 1900                 1905             


Ala Asn  Pro Asn Phe Gly Ala  Leu Val Thr Glu Leu  Gly Thr Gly 
    1910                 1915                 1920             


Tyr Thr  Trp Trp Arg Asn Ser  Arg Glu Phe Lys Leu  Thr Pro Trp 
    1925                 1930                 1935             


His Asn  Asp Ala Ala Phe Asp  Pro Pro Gly Glu Ala  Val Tyr Ile 
    1940                 1945                 1950             


Ala Asp  Leu Asp Arg Gly Ile  Ile Ala Ser Ala Thr  Pro Ser Pro 
    1955                 1960                 1965             


Ala Gly  Asp Glu Arg Thr Tyr  Asp Val Thr His Arg  Pro Gly Val 
    1970                 1975                 1980             


Thr Thr  Phe Glu Ser Asp Val  Glu Gly Val Arg Val  Thr Leu His 
    1985                 1990                 1995             


Val Phe  Val Asp Ser Ala Glu  Pro Ala Lys Trp Met  Arg Val Arg 
    2000                 2005                 2010             


Leu Arg  Asn Gln Ser Gly Glu  Glu Arg Arg Ile Arg  Val Ala Pro 
    2015                 2020                 2025             


Tyr Ala  Glu Trp Val Leu Gly  Val Asp Pro Phe Ser  Asn Thr Pro 
    2030                 2035                 2040             


Leu Val  Val Val Arg Lys Met  Gly Glu Ala Asp Ala  Ile Ala Ala 
    2045                 2050                 2055             


Glu Asn  Arg Tyr Gln Glu Ala  Phe Arg Gly Ala Leu  Gly Phe Leu 
    2060                 2065                 2070             


Ala Val  Gly Gly Ala Gly Arg  Thr Thr Gly Trp Leu  Gly Asp Lys 
    2075                 2080                 2085             


Thr Arg  Phe Leu Gly Asp Gly  Ser Tyr Ala Arg Pro  Asp Ala Leu 
    2090                 2095                 2100             


Leu Glu  Asp Ala Trp Arg Gly  Gly Asp Gly Pro Thr  Pro Thr Pro 
    2105                 2110                 2115             


Cys Ala  Val Leu Ala Arg Asp  Leu Asp Leu Gly Pro  His Glu Glu 
    2120                 2125                 2130             


Ala Glu  Val Val Ile Leu Leu  Gly Ala Ala Pro Asp  Glu His Glu 
    2135                 2140                 2145             


Ala Ala  Arg Leu Ala Arg Leu  Ala Asp Pro Ala Ala  Ala Asp Arg 
    2150                 2155                 2160             


Ala Leu  Arg Glu Val Thr Arg  Phe Trp Asp Asp Leu  Leu Gly Arg 
    2165                 2170                 2175             


Val Gln  Ile Arg Thr Pro Asp  Arg Ala Phe Asp Ile  Leu Met Asn 
    2180                 2185                 2190             


Gly Trp  Leu Val Tyr Gln Ala  Leu Ala Cys Arg Leu  Trp Ala Arg 
    2195                 2200                 2205             


Thr Ala  Phe Tyr Gln Ala Gly  Gly Ala Phe Gly Phe  Arg Asp Gln 
    2210                 2215                 2220             


Leu Gln  Asp Ala Leu Ala Leu  Ile His Ala Arg Pro  Asp Ile Leu 
    2225                 2230                 2235             


Arg Asp  Gln Ile Leu Arg Ala  Ala Arg His Gln Tyr  Val Glu Gly 
    2240                 2245                 2250             


Asp Val  Gln His Trp Trp His  Glu Glu Leu Gly Lys  Gly Ile Arg 
    2255                 2260                 2265             


Thr Arg  Phe Ser Asp Asp Leu  Leu Trp Leu Pro Tyr  Ala Val Ser 
    2270                 2275                 2280             


Arg Tyr  Leu Glu Ala Thr Gly  Asp Ala Ala Leu Leu  Asp Glu Arg 
    2285                 2290                 2295             


Ala Pro  Tyr Leu Val Ser Ala  Pro Leu Gly Asp Gly  Glu Leu Glu 
    2300                 2305                 2310             


Arg Tyr  Glu Asp Ser Val Trp  Ser Gln Glu Glu Gly  Thr Leu Ala 
    2315                 2320                 2325             


Glu His  Val Ala Arg Ala Val  Glu Arg Ala Leu His  Phe Gly Asp 
    2330                 2335                 2340             


His Gly  Leu Pro Leu Ile Gly  Ile Gly Asp Trp Asn  Asp Gly Leu 
    2345                 2350                 2355             


Ser Arg  Val Gly Ala Lys Gly  Arg Gly Glu Ser Val  Trp Leu Ala 
    2360                 2365                 2370             


Trp Phe  Leu Ala Asp Val Val  Arg Arg Val Ala Glu  Ile Asp His 
    2375                 2380                 2385             


Pro Glu  Phe Ala Gln His Arg  Ala Arg Trp Leu Ala  Met Arg Glu 
    2390                 2395                 2400             


Arg Val  Leu Ala Ala Ala Asn  Glu Ser Ala Trp Asp  Gly Gln Trp 
    2405                 2410                 2415             


Tyr Arg  Arg Ala Ile Thr Asp  Asp Gly Leu Trp Leu  Gly Ser Ala 
    2420                 2425                 2430             


Ala Ser  Pro Ala Cys Arg Val  Asp Ala Ile Ala Gln  Ser Trp Ala 
    2435                 2440                 2445             


Val Ile  Ser Gly Gly Ala Pro  Pro Asp Arg Ala Val  Arg Ala Met 
    2450                 2455                 2460             


Glu Ser  Phe Asp Arg Glu Leu  Val Asp Arg Arg Leu  Gly Val Ala 
    2465                 2470                 2475             


His Leu  Leu Gln Pro Ala Phe  Arg Asp Leu Arg Pro  Ser Pro Gly 
    2480                 2485                 2490             


Tyr Ile  Gln Gly Tyr Pro Pro  Gly Ile Arg Glu Asn  Gly Gly Gln 
    2495                 2500                 2505             


Tyr Thr  His Gly Val Ile Trp  Ser Val Ile Ala Trp  Thr Arg Leu 
    2510                 2515                 2520             


Gly Arg  Ala Asp Glu Ala Tyr  Glu Leu Phe Ser Met  Leu Asn Pro 
    2525                 2530                 2535             


Ile His  His Ala Asp Thr Pro  Arg Glu Val Glu Arg  Tyr Gly Asn 
    2540                 2545                 2550             


Glu Pro  Tyr Val Met Ser Ala  Asp Val Tyr Thr Ala  Glu Pro Asn 
    2555                 2560                 2565             


Val Gly  Gln Gly Gly Trp Ser  Trp Tyr Thr Gly Ala  Ala Ser Trp 
    2570                 2575                 2580             


Met Tyr  Gln Ala Gly Leu Glu  Ala Ile Leu Gly Ile  Arg Arg His 
    2585                 2590                 2595             


Gly Thr  Arg Leu Leu Val Glu  Pro Cys Val Pro Ala  His Trp Pro 
    2600                 2605                 2610             


Gly Phe  Glu Val Ala Tyr Arg  Tyr Gly Ser Thr Leu  Tyr Arg Ile 
    2615                 2620                 2625             


Arg Val  Glu Arg Ala Pro Gln  Gly Ala Glu Ala Arg  Asp Ser Ala 
    2630                 2635                 2640             


Leu Thr  Val Glu Gly Val Ala  Pro Ala Glu Ile Asp  Leu Val Asp 
    2645                 2650                 2655             


Asp Gly  Gln Glu His His Val  Val Val Trp Leu Ala  Ala Glu Gly 
    2660                 2665                 2670             


Ala Glu  Val Leu Ser Asp Val  Gln Thr Val Ala Ala  Arg Pro Arg 
    2675                 2680                 2685             


Glu Gly  Ala Arg Arg Tyr Arg  Met Ser Ser Gly Ala  Arg Ala Phe 
    2690                 2695                 2700             


Pro Ala  Ser Ala Ala Tyr Arg  Lys Arg Asp Pro Gln  Pro 
    2705                 2710                 2715     


<210>  203
<211>  2922
<212>  PRT
<213>  Clostridium thermocellum 

<400>  203

Met Gln Met Gln Leu Tyr Ile Leu Tyr Leu Leu Gly Leu Phe Gly Ile 
1               5                   10                  15      


Leu Leu Cys Leu Phe Leu Leu Ala Ile Phe Ser Asn Cys Asn Glu Arg 
            20                  25                  30          


Gln Arg Gln Leu Lys Val Gln Asp Ala Ser Leu Thr Phe Asp Glu Leu 
        35                  40                  45              


Glu Ala Tyr Ala Lys Glu Ile Ala Ile Glu His Ser Val Ser Gly Lys 
    50                  55                  60                  


Lys Ser Met Phe Ser Trp Pro Ile Pro Arg Met Asn Asp Asn Tyr Arg 
65                  70                  75                  80  


Tyr Ile Met Ser Val Tyr Lys Glu Met Asn Glu Asp Val Gln Lys Gly 
                85                  90                  95      


Ile Ser Thr Thr Pro Ala Ala Glu Trp Leu Leu Asp Asn Phe Tyr Ile 
            100                 105                 110         


Ile Glu Glu Gln Val Lys Ser Leu Arg Arg Asp Leu Thr Lys Glu Val 
        115                 120                 125             


Tyr Ala Lys Leu Pro Val Leu Asp Ser Gly His Leu Lys Gly Tyr Ala 
    130                 135                 140                 


Arg Ile Tyr Ser Ile Ala Leu Glu Leu Leu Ser His Thr Asp Gly Arg 
145                 150                 155                 160 


Ile Asp Glu Lys Val Leu Val Asn Tyr Ile Lys Ala Tyr Gln Ser Asn 
                165                 170                 175     


Asn Val Leu Thr Gly Arg Glu Leu Trp Ala Phe Pro Ile Met Leu Lys 
            180                 185                 190         


Leu Val Leu Ile Glu Lys Thr Arg Tyr Ile Cys Glu Lys Ile Ala Lys 
        195                 200                 205             


Ala Gln Glu Gln Arg Arg Lys Val Glu Glu Ile Leu Lys Ala Phe Asp 
    210                 215                 220                 


Glu Asn Ile Glu Asn Thr Thr Gln Leu Ile Thr Ala Ile Asp Asn Glu 
225                 230                 235                 240 


Leu Lys Gly Lys Tyr Glu Val Asn Ser Ala Phe Ile Glu Tyr Leu Ala 
                245                 250                 255     


Tyr Lys Phe Arg Lys Met Gly Arg Ala Tyr Thr His Val Leu Arg Tyr 
            260                 265                 270         


Ile Asp Glu Arg Leu Gly Glu Ser Gly Thr Thr Val Asp Asp Ile Thr 
        275                 280                 285             


Gln Lys Glu His Asn Glu Gln Thr Ala Ser Lys Ala Ser Ile Gly Asn 
    290                 295                 300                 


Cys Ile Met Ser Leu Lys Phe Ile Ser Thr Val Asn Trp Val Asp Ile 
305                 310                 315                 320 


Phe Glu Gln Leu Ser Lys Val Glu Gln Ile Leu Arg Glu Asp Pro Ser 
                325                 330                 335     


Gly Phe Tyr Ser Leu Met Asp Phe Asp Ser Arg Asn Tyr Tyr Arg Asn 
            340                 345                 350         


Arg Val Glu Lys Leu Ala Leu Lys Tyr Lys Val Ser Glu Ser His Val 
        355                 360                 365             


Ala Lys Lys Ala Val Glu Leu Ala Arg Asn Ala Val Glu Asn Gly Asn 
    370                 375                 380                 


Leu Thr Asp Lys Arg Leu Thr His Val Gly Tyr Tyr Leu Val Gly Lys 
385                 390                 395                 400 


Gly Ile Cys Glu Leu Glu Lys Glu Ile Gly Tyr Glu Lys Ser Phe Asn 
                405                 410                 415     


Gln Arg Met Phe Glu Arg Ile Lys Glu His Pro Ala Cys Leu Tyr Phe 
            420                 425                 430         


Gly Phe Ile Gly Phe Ile Thr Val Leu Leu Leu Leu Cys Val Thr Lys 
        435                 440                 445             


Tyr Ser Leu Phe Arg Ala Glu Lys Tyr Gly Ile Ala Leu Ser Ile Ile 
    450                 455                 460                 


Ala Val Leu Ala Thr Ile Ile Pro Ala Thr Asp Ile Ala Val Asn Phe 
465                 470                 475                 480 


Val Asn Trp Val Leu Cys Lys Met Ile Lys Pro Ser Leu Leu Pro Lys 
                485                 490                 495     


Leu Asp Phe Glu Asn Gly Ile Pro Glu Glu Tyr Ala Thr Met Val Val 
            500                 505                 510         


Ile Pro Ala Leu Leu Pro Asp Glu Asn Arg Ala Arg Glu Leu Ile Asp 
        515                 520                 525             


Asn Leu Glu Val Tyr Tyr Leu Ala Asn Arg Glu Lys Asn Leu Tyr Phe 
    530                 535                 540                 


Ser Ile Ala Gly Asp Phe Lys Asp Ala Pro Asn Lys Glu Met Ala Gly 
545                 550                 555                 560 


Asp Lys Lys Ile Ile Glu Thr Ala Leu Gly Arg Ile Ala Glu Leu Asn 
                565                 570                 575     


Glu Lys Tyr Gly Arg Lys Asn Glu Gly Gly Glu Lys Asp Ser Arg Asp 
            580                 585                 590         


Ile Phe Tyr Tyr Phe His Arg His Arg Gln Phe Asn Glu Lys Gln Asn 
        595                 600                 605             


Lys Trp Met Gly Trp Glu Arg Lys Arg Gly Ala Leu Leu Glu Phe Asn 
    610                 615                 620                 


Glu Val Leu Leu Gly Ser Arg Thr Thr Ser Tyr Ser Ile Met Ser His 
625                 630                 635                 640 


Asp Val Ser Gln Leu Pro Lys Ile Lys Tyr Val Ile Thr Leu Asp Ala 
                645                 650                 655     


Asp Thr Ile Leu Pro Leu Gly Ala Ala Arg Lys Leu Ile Gly Thr Met 
            660                 665                 670         


Ala His Pro Leu His Arg Pro Val Ile Asp Glu Gln Lys Gly Ile Val 
        675                 680                 685             


Thr Glu Gly Tyr Gly Leu Leu Gln Pro Arg Ile Gly Phe Asp Ile Glu 
    690                 695                 700                 


Ser Val Asn Lys Ser Leu Phe Ser Arg Ile Phe Ala Gly Glu Glu Gly 
705                 710                 715                 720 


Ile Asp Pro Tyr Ala Ser Ala Ile Ser Asp Val Tyr Gln Asp Leu Phe 
                725                 730                 735     


Gly Glu Gly Ile Phe Thr Gly Lys Gly Ile Tyr Asp Leu Glu Val Phe 
            740                 745                 750         


Gln Lys Leu Leu Lys Asp Ala Ile Pro Asp Asn Thr Val Leu Ser His 
        755                 760                 765             


Asp Leu Leu Glu Gly Ser Tyr Val Arg Ala Gly Leu Val Thr Asp Ile 
    770                 775                 780                 


Glu Phe Ile Asp Gly Tyr Pro Ser Lys Leu Asn Ser Tyr Ala Met Arg 
785                 790                 795                 800 


Leu His Arg Trp Val Arg Gly Asp Trp Gln Leu Leu Pro Trp Leu Arg 
                805                 810                 815     


Gly Lys Thr Lys Asp Arg Lys Gly Asn Val Ile Lys Asn Pro Leu Ser 
            820                 825                 830         


Leu Ile Ser Arg Trp Lys Ile Leu Asp Asn Leu Arg Arg Ser Ile Val 
        835                 840                 845             


Ala Pro Ser Ile Thr Leu Leu Ile Ala Leu Gly Phe Ser Ile Leu Pro 
    850                 855                 860                 


Gly Ser Ser Leu Phe Trp Leu Gly Ala Ser Leu Leu Thr Ile Tyr Phe 
865                 870                 875                 880 


Pro Leu Ile Thr Gly Thr Ile Asp Tyr Ile Ala Ser Lys Pro Leu Gly 
                885                 890                 895     


Ala Ile Thr Ser Lys Arg Tyr Lys Pro Ala Ile Cys Gly Leu Lys Ala 
            900                 905                 910         


Ser Phe Leu Gln Met Thr Leu Gln Phe Val Phe Leu Pro Tyr Asn Ala 
        915                 920                 925             


Trp Leu Met Val His Ala Ala Val Leu Ser Leu Val Arg Val Leu Phe 
    930                 935                 940                 


Thr Lys Arg Asn Met Leu Glu Trp Val Thr Ala Leu Asp Ala Glu Arg 
945                 950                 955                 960 


Gly Leu Lys Asn Ser Leu Lys Gly Tyr Val Ile Lys Met Lys Ala Ala 
                965                 970                 975     


Ala Phe Gln Ala Leu Val Val Val Val Leu Ala Phe Ala Phe Lys Thr 
            980                 985                 990         


Gly Phe Ser Ala Ala Val Ser Val  Leu Pro Phe Ala Val  Trp Val Ser 
        995                 1000                 1005             


Ser Pro  Phe Ile Ala Tyr Trp  Ile Ser Lys Glu Thr  Val Tyr Lys 
    1010                 1015                 1020             


Thr Glu  Thr Leu Ser Asp Glu  Glu Asn Leu Glu Leu  Arg Arg Ile 
    1025                 1030                 1035             


Ala Arg  Lys Thr Trp Arg Tyr  Tyr Glu Glu Phe Val  Asn Arg Arg 
    1040                 1045                 1050             


Asn Asn  Tyr Leu Ala Pro Asp  Asn Phe Gln Glu Asp  Pro Pro Asn 
    1055                 1060                 1065             


Gly Ile  Ala Tyr Arg Thr Ser  Pro Thr Asn Ile Gly  Leu Gly Met 
    1070                 1075                 1080             


Leu Ala  Ala Leu Thr Ala Arg  Asp Leu Gly Tyr Ile  Gly Thr Leu 
    1085                 1090                 1095             


Glu Leu  Cys Asp Ile Ile Ser  Arg Thr Met Ser Thr  Val Glu Lys 
    1100                 1105                 1110             


Met Glu  Lys Trp Asn Gly His  Leu Tyr Asn Trp Tyr  Asp Thr Arg 
    1115                 1120                 1125             


Thr Leu  Glu Thr Leu Arg Pro  Arg Tyr Ile Ser Thr  Val Asp Ser 
    1130                 1135                 1140             


Gly Asn  Phe Val Cys Tyr Leu  Ile Thr Leu Lys Glu  Gly Leu Ala 
    1145                 1150                 1155             


Glu Tyr  Leu Asn Arg Pro Leu  Glu Asp Arg Ala Phe  Ile Asp Gly 
    1160                 1165                 1170             


Ile Arg  Asp Thr Ala Ser Leu  Ile Ala Asp Glu Asn  Glu Asn Pro 
    1175                 1180                 1185             


Tyr Lys  Asp Ile Ser Cys Leu  Lys Glu Cys Ile Val  Ile Ser Glu 
    1190                 1195                 1200             


Gly Arg  Ser Tyr Val Asp Ile  Pro Gln Met Met Lys  Ala Leu Thr 
    1205                 1210                 1215             


Lys Leu  Ser Glu Asp Gly Asn  Lys Met Lys Asp Ser  Lys Asp Val 
    1220                 1225                 1230             


Trp Lys  Ala Lys Val Asp Ser  Met Ile Glu Met Leu  Lys Ile Glu 
    1235                 1240                 1245             


Leu Tyr  Thr Tyr Met Pro Trp  Cys Asp Met Ile Asp  Glu Leu Thr 
    1250                 1255                 1260             


Glu Ala  Phe Glu Lys Ser Glu  Ala Asp Ile Lys Glu  Ala Phe His 
    1265                 1270                 1275             


Gly Ile  Ile Arg Lys Leu Asn  Ser Asp Tyr Ser Leu  Lys Ala Met 
    1280                 1285                 1290             


Pro Val  Val Tyr Arg Glu Thr  Ile Lys Gln Ile Glu  Lys Leu Arg 
    1295                 1300                 1305             


Lys Lys  Leu Lys Asp Gly Gln  Gln Lys Asn Ile Glu  Gly Leu Asp 
    1310                 1315                 1320             


Arg Leu  Lys Glu Ala Leu Glu  Gly Ala Thr Glu Ser  Ala Asp Lys 
    1325                 1330                 1335             


Leu Val  Lys Arg Tyr Val Asp  Leu Ile Asn Arg Ile  Cys Arg Ile 
    1340                 1345                 1350             


Ala Asp  Glu Thr Glu Phe Val  His Leu Tyr Asp Lys  Lys Lys Gln 
    1355                 1360                 1365             


Leu Phe  Ser Ile Gly Tyr Asn  Ile Glu Glu Asn Ser  Leu Thr Asn 
    1370                 1375                 1380             


Ser Tyr  Tyr Asp Leu Leu Ala  Ser Glu Ala Arg Gln  Thr Ser Tyr 
    1385                 1390                 1395             


Ile Ala  Ile Ala Arg Gly Glu  Val Asp Gln Gln His  Trp Phe Lys 
    1400                 1405                 1410             


Leu Gly  Arg Thr Leu Thr Gln  Ile Asp Arg Tyr Lys  Gly Met Val 
    1415                 1420                 1425             


Ser Trp  Ser Gly Thr Met Phe  Glu Tyr Phe Met Pro  Leu Leu Ile 
    1430                 1435                 1440             


Met Lys  Ser His Lys Asn Thr  Leu Leu Asp Glu Thr  Tyr Ser Phe 
    1445                 1450                 1455             


Val Val  Arg Ser Gln Lys Lys  Tyr Gly Lys Gln Arg  Asn Leu Pro 
    1460                 1465                 1470             


Trp Gly  Ile Ser Glu Ser Gly  Phe Tyr Ser Phe Asp  Ile Asn Leu 
    1475                 1480                 1485             


Asp Tyr  Gln Tyr Lys Ala Phe  Gly Val Pro Trp Leu  Gly Leu Lys 
    1490                 1495                 1500             


Arg Gly  Leu Val Glu Asp Met  Val Val Ser Pro Tyr  Ala Thr Met 
    1505                 1510                 1515             


Leu Val  Leu Pro Leu Val Pro  Arg Asp Ala Met Asp  Asn Leu Lys 
    1520                 1525                 1530             


Arg Leu  Ile Ala Glu Gly Ala  Tyr Gly His Tyr Gly  Met Tyr Glu 
    1535                 1540                 1545             


Ala Ile  Asp Tyr Thr Pro Glu  Arg Ile Pro Leu Gly  Glu Lys Lys 
    1550                 1555                 1560             


Gly Ile  Val Lys Ser Tyr Met  Ala His His Gln Gly  Met Ser Ile 
    1565                 1570                 1575             


Leu Ala  Leu Asn Asn Tyr Phe  Asn Asp Asn Ile Met  Gln Lys Arg 
    1580                 1585                 1590             


Phe His  Ala Asp Pro Val Val  Asp Ala Ala Lys Leu  Leu Leu Met 
    1595                 1600                 1605             


Glu Lys  Val Pro Ser Asn Ile  Val Phe Thr Lys Glu  Asn Lys Glu 
    1610                 1615                 1620             


Lys Ile  Leu Pro Phe Lys Asp  Val Val Tyr Asp Glu  Lys Asp Phe 
    1625                 1630                 1635             


Leu Arg  Glu Cys Gly Met Pro  Asp Pro Val Leu Pro  Lys Ala His 
    1640                 1645                 1650             


Ile Leu  Ser Asn Gly Asn Tyr  Ser Val Met Val Thr  Asp Arg Gly 
    1655                 1660                 1665             


Thr Gly  Tyr Ser Arg Trp Lys  Asn Leu Asp Val Thr  Arg Trp Arg 
    1670                 1675                 1680             


Glu Asp  Val Thr Leu Asp Asn  Tyr Gly Met Phe Phe  Tyr Ile Arg 
    1685                 1690                 1695             


Asp Val  Gln Asn Asp Glu Val  Trp Thr Ser Thr Phe  Ala Pro Gly 
    1700                 1705                 1710             


Arg Lys  Lys Pro Asp Glu Tyr  Lys Val Glu Phe Thr  Ser Gly Lys 
    1715                 1720                 1725             


Ala Lys  Tyr Tyr Arg Lys Asp  Gly Asp Ile Asp Thr  Leu Thr Glu 
    1730                 1735                 1740             


Ile Val  Val Cys Ala Gly Glu  Asn Ala Glu Ile Arg  Ser Ile Thr 
    1745                 1750                 1755             


Leu Ala  Asn His Gly Gln Glu  Ser Cys Val Met Glu  Ile Thr Ser 
    1760                 1765                 1770             


Tyr Phe  Glu Pro Val Leu Ser  His His Gly Ala Asp  Ile Ala His 
    1775                 1780                 1785             


Pro Ala  Phe Gly Asn Leu Phe  Ile Arg Thr Glu Phe  Leu Ala Glu 
    1790                 1795                 1800             


His Asn  Cys Leu Ile Ala Gly  Arg Arg Pro Arg Ser  Glu Lys Glu 
    1805                 1810                 1815             


Lys Pro  Val Trp Ile Met Asn  Thr Val Val Leu Glu  Gly Glu Gly 
    1820                 1825                 1830             


Val Gly  Ser Leu Gln Tyr Glu  Thr Asp Arg Met Gln  Phe Ile Gly 
    1835                 1840                 1845             


Arg Gly  Arg Asn Val Ser Glu  Pro Val Ala Leu Glu  Pro His Arg 
    1850                 1855                 1860             


Pro Leu  Thr Asn Ser Val Gly  Ala Val Leu Asp Pro  Val Met Ser 
    1865                 1870                 1875             


Phe Arg  Gln Ile Val Arg Val  Glu Pro Gly Lys Ser  Val Lys Ile 
    1880                 1885                 1890             


Ser Phe  Val Thr Ala Val Ala  Asn Ser Arg Glu Asp  Val Val Glu 
    1895                 1900                 1905             


Met Ala  Thr Lys Phe Lys Ser  Pro Gln Val Ile Lys  Asp Glu Leu 
    1910                 1915                 1920             


Gly Met  Ala Val Thr Lys Ser  Arg Val Glu Ala Arg  Tyr Leu Asn 
    1925                 1930                 1935             


Leu Asp  Thr Glu Glu Ile Glu  Leu Tyr Gln Asp Met  Ile Ser His 
    1940                 1945                 1950             


Ile Leu  Phe Ile Ser Pro Leu  Gln Arg Gln Lys Gln  Lys Trp Val 
    1955                 1960                 1965             


Met Asn  Asn Lys Lys Gly Gln  Pro Gly Leu Trp Pro  Tyr Gly Ile 
    1970                 1975                 1980             


Ser Gly  Asp Ile Pro Ile Val  Leu Val Met Leu Asp  Lys Thr Asp 
    1985                 1990                 1995             


Asp Ile  Asp Ile Val Arg Glu  Val Leu Lys Ala His  Glu Tyr Trp 
    2000                 2005                 2010             


Arg Leu  Lys Lys Leu Ala Val  Asp Leu Val Ile Leu  Asn Glu Glu 
    2015                 2020                 2025             


Glu Asn  Ser Tyr Thr Asn Pro  Val Asn Ser Leu Leu  Met Asp Ile 
    2030                 2035                 2040             


Ile Ala  Glu Ser His Ala His  Asp Leu Ile Asn Lys  Pro Gly Gly 
    2045                 2050                 2055             


Val Phe  Ile Leu Lys Lys Ser  Asn Met Pro Pro Glu  Asp Ile Asp 
    2060                 2065                 2070             


Leu Ile  Cys Ser Val Ser Arg  Ile Ile Leu Lys Gly  Asp Ala Gly 
    2075                 2080                 2085             


Asp Leu  Lys Asp Gln Val Lys  Tyr Ala Arg Ser Ile  Ala Leu Ala 
    2090                 2095                 2100             


Glu Phe  Lys Gln Phe Glu Lys  Lys Pro Ala Ser Tyr  Asp Ser Lys 
    2105                 2110                 2115             


Leu Ala  Lys Asp Leu Glu Leu  Asn Phe Tyr Asn Gly  Leu Gly Gly 
    2120                 2125                 2130             


Phe Gly  Lys Asp Gly Lys Glu  Tyr Val Ile Phe Leu  Glu Asn Gly 
    2135                 2140                 2145             


Gln Asn  Thr Pro Leu Pro Trp  Ile Asn Val Ile Ser  Asn Gln Arg 
    2150                 2155                 2160             


Phe Gly  Phe Ile Val Thr Glu  Ser Gly Ser Gly Tyr  Thr Trp Phe 
    2165                 2170                 2175             


Glu Asn  Ser Arg Glu Asn Lys  Leu Thr Pro Trp Ser  Asn Asp Pro 
    2180                 2185                 2190             


Val Ser  Asp Thr Pro Gly Glu  Ile Leu Tyr Val Met  Asp Glu His 
    2195                 2200                 2205             


Ala Gly  Asp Val Trp Ser Val  Thr Pro Leu Pro Val  Arg Glu Lys 
    2210                 2215                 2220             


Glu Pro  Tyr Met Ile Arg His  Gly Phe Gly Tyr Thr  Val Phe Ser 
    2225                 2230                 2235             


His Ala  Ser His Gly Ile Glu  Gln Glu Met Val Gln  Phe Val Pro 
    2240                 2245                 2250             


Val Asp  Asp Ser Val Lys Ile  Ser Ile Leu Lys Leu  Lys Asn Gln 
    2255                 2260                 2265             


Ser Gln  Glu Asn Arg Gly Leu  Ser Leu Thr Tyr Tyr  Ile Arg Pro 
    2270                 2275                 2280             


Val Leu  Gly Val Ser Asp Gln  Phe Thr Ala Met His  Ile Asn Thr 
    2285                 2290                 2295             


Lys Ala  Asp Asn Gly Met Ile  Val Ile Lys Asn Asn  Tyr Asn Asp 
    2300                 2305                 2310             


Glu Phe  Pro Gly Arg Val Ala  Phe Ile Asp Ser Ser  Leu Lys Val 
    2315                 2320                 2325             


Asn Ser  Leu Thr Cys Asp Arg  Lys Glu Phe Phe Gly  Ala Gly Asp 
    2330                 2335                 2340             


Ile Ala  Asn Pro Glu Gly Ile  Lys Arg Thr Ser Leu  Ser Gly Thr 
    2345                 2350                 2355             


Thr Gly  Ala Gly Phe Asp Pro  Cys Ala Ala Ile Ser  Val Ser Val 
    2360                 2365                 2370             


Asn Leu  Lys Pro Asp Glu Glu  Lys Glu Ile Ile Phe  Leu Leu Gly 
    2375                 2380                 2385             


Ala Gly  Arg Asp Glu Glu Glu  Ala Arg Gln Leu Ser  Ala Lys Tyr 
    2390                 2395                 2400             


Lys Lys  Leu Glu Glu Ala Lys  Lys Ala Leu Gly Glu  Val Lys Lys 
    2405                 2410                 2415             


Phe Trp  Glu Leu Lys Leu Gly  Ala Leu Gln Phe Glu  Thr Pro Asn 
    2420                 2425                 2430             


Thr Ala  Met Asp Ile Leu Leu  Asn Gly Trp Leu Leu  Tyr Gln Val 
    2435                 2440                 2445             


Val Ser  Cys Arg Leu Trp Thr  Arg Ser Gly Phe Tyr  Gln Ser Gly 
    2450                 2455                 2460             


Gly Ala  Tyr Gly Phe Arg Asp  Gln Leu Gln Asp Ser  Ile Ser Leu 
    2465                 2470                 2475             


Thr His  Ile Trp Pro Glu Ala  Thr Arg Asn Gln Ile  Leu Leu His 
    2480                 2485                 2490             


Ser Arg  His Gln Phe Ile Glu  Gly Asp Val Gln His  Trp Trp His 
    2495                 2500                 2505             


Glu Glu  Lys Tyr Lys Gly Thr  Arg Thr Lys Phe Ser  Asp Asp Leu 
    2510                 2515                 2520             


Leu Trp  Met Pro Tyr Ala Thr  Ile Glu Tyr Ile Arg  Ile Thr Gly 
    2525                 2530                 2535             


Asp Tyr  Asp Ile Leu Tyr Glu  Glu Thr Pro Phe Leu  Glu Asp Glu 
    2540                 2545                 2550             


Pro Leu  Lys Glu Phe Glu Asp  Glu Ala Tyr Arg Val  Pro Arg Ile 
    2555                 2560                 2565             


Ser His  Thr Val Ser Thr Leu  Tyr Asp His Cys Ile  Arg Ala Ile 
    2570                 2575                 2580             


Asn Arg  Ser Leu Lys Phe Gly  Glu His Gly Ile Pro  Leu Ile Gly 
    2585                 2590                 2595             


Ser Gly  Asp Trp Asn Asp Gly  Met Asn Thr Val Gly  Asn Lys Gly 
    2600                 2605                 2610             


Lys Gly  Glu Ser Val Trp Leu  Gly Trp Phe Leu Tyr  Ser Ile Leu 
    2615                 2620                 2625             


Lys Asn  Phe Ala Pro Leu Cys  Glu Arg Met Gly Asp  Asn Glu Leu 
    2630                 2635                 2640             


Ala Lys  Arg Tyr Leu Asp Thr  Ala Asp Arg Ile Val  Glu Asn Ile 
    2645                 2650                 2655             


Glu Lys  Asn Ala Trp Asp Gly  Lys Trp Tyr Arg Arg  Ala Tyr Phe 
    2660                 2665                 2670             


Asp Asn  Gly Val Pro Leu Gly  Ser Ile Gln Asn Ser  Glu Cys Gln 
    2675                 2680                 2685             


Ile Asp  Ser Leu Ala Gln Ser  Trp Ala Val Ile Ser  Glu Gly Gly 
    2690                 2695                 2700             


Asp Lys  Glu Arg Ile Ala Glu  Ala Met Ser Ala Leu  Glu Asn Tyr 
    2705                 2710                 2715             


Leu Val  Lys Arg Asp Glu Gly  Leu Ile Lys Leu Leu  Thr Pro Pro 
    2720                 2725                 2730             


Phe Asp  Glu Gly Asp Leu Glu  Pro Gly Tyr Ile Lys  Ser Tyr Val 
    2735                 2740                 2745             


Pro Gly  Val Arg Glu Asn Gly  Gly Gln Tyr Thr His  Ala Ala Ala 
    2750                 2755                 2760             


Trp Val  Val Met Ala Phe Ala  Lys Met Gly Asp Gly  Glu Lys Ala 
    2765                 2770                 2775             


Met Glu  Leu Phe Asp Leu Leu  Asn Pro Ile Asn His  Ser Arg Thr 
    2780                 2785                 2790             


His Ile  Glu Tyr Ser Arg Tyr  Lys Val Glu Pro Tyr  Val Met Ala 
    2795                 2800                 2805             


Ala Asp  Val Tyr Ser Val Pro  Pro His Thr Gly Arg  Gly Gly Trp 
    2810                 2815                 2820             


Thr Trp  Tyr Thr Gly Ser Ala  Gly Trp Ile Tyr Arg  Val Gly Phe 
    2825                 2830                 2835             


Glu Tyr  Ile Leu Gly Phe Lys  Lys Arg Gly Glu Thr  Leu Glu Ile 
    2840                 2845                 2850             


Asp Pro  Cys Ile Pro Gly Lys  Trp Thr Asp Phe Thr  Ile Lys Tyr 
    2855                 2860                 2865             


Arg Tyr  Tyr Asp Thr Asp Tyr  Ile Ile Glu Val Lys  Asn Pro Glu 
    2870                 2875                 2880             


Gly Val  Asn Thr Gly Val Lys  Lys Val Ile Val Asp  Gly Lys Val 
    2885                 2890                 2895             


Cys Asp  Asp Gly Lys Val Gln  Leu Val Asn Asp Lys  Asp Thr His 
    2900                 2905                 2910             


Lys Val  Glu Val Tyr Met Gly  Lys Lys 
    2915                 2920         


<210>  204
<211>  2887
<212>  PRT
<213>  Thermoanaerobacter ethanolicus

<400>  204

Met Trp Tyr Ile Val Ala Leu Val Leu Leu Leu Ile Ala Thr Ser Ile 
1               5                   10                  15      


Val His Ile Ser Lys Asn Gln Arg Leu Ser Arg Glu Asp Ser Ile Arg 
            20                  25                  30          


Asp Phe Asp Asp Ile Ile Leu Asn Ser Glu Glu Met Glu Lys His Ala 
        35                  40                  45              


Ala Glu Ile Ala Gln Asn His Asn Ile Met Lys Arg Thr Lys Leu Ser 
    50                  55                  60                  


Tyr Leu Leu Ile Pro Arg Met Asn Lys Asn Tyr Asn Tyr Ile Lys Asn 
65                  70                  75                  80  


Val Tyr Arg Asn Leu Asn Ser Ile Leu Lys Glu Glu Asp Val Tyr Ile 
                85                  90                  95      


Ser Gln Glu Glu Glu Trp Leu Leu Asp Asn Phe Tyr Ile Ile Glu Glu 
            100                 105                 110         


Gln Val Lys Glu Ile Arg Lys Ser Leu Ser Lys Ser Tyr Tyr Ser Gly 
        115                 120                 125             


Leu Pro Gly Leu Lys Asn Gly Leu Phe Lys Gly Tyr Pro Arg Ile Tyr 
    130                 135                 140                 


Ala Ile Ala Phe Glu Leu Val Leu His Thr Asp Gly Lys Ile Asp Glu 
145                 150                 155                 160 


Lys Ala Ile Ile Asn Phe Ile Lys Ala Tyr Gln Thr Lys Ala Leu Leu 
                165                 170                 175     


Ser Ser Ser Glu Leu Trp Ala Leu Ser Leu Met Ile Arg Ile Ala Leu 
            180                 185                 190         


Val Glu Lys Ile Lys Lys Ile Cys Glu Lys Ile Val Glu Thr Arg His 
        195                 200                 205             


Gln Arg Glu Lys Ala Glu Lys Ile Leu Thr Leu Leu Leu Glu Lys Glu 
    210                 215                 220                 


Met Lys Tyr Glu Glu Val Lys Lys Leu Ile Arg Asn Asn Ile Asn Val 
225                 230                 235                 240 


Ala Asp Arg Phe Pro Leu Gln Phe Ile Glu His Leu Val Ser Arg Leu 
                245                 250                 255     


Arg Lys Glu Gly Ser Asn Ser Val Asn Val Ile Gln Ser Ile Glu Lys 
            260                 265                 270         


Ile Leu Met Glu Tyr Asp Thr Ser Ile Asn Asp Val Ala Glu Lys Ala 
        275                 280                 285             


His Gln Ile Gln Ala Lys Arg Gln Ile Ser Ile Gly Asn Ala Ile Thr 
    290                 295                 300                 


Ser Leu Lys Thr Val Ser Ser Leu Asp Trp Ala Gln Ile Phe Glu Ser 
305                 310                 315                 320 


Leu Ser Ser Val Glu Gln Val Leu Arg Gln Asp Pro Asp Gly Thr Tyr 
                325                 330                 335     


Pro Lys Met Asp Phe Glu Ser Arg Asp Tyr Tyr Arg His Glu Ile Glu 
            340                 345                 350         


Lys Ile Ala Lys Tyr Tyr Asn Thr Ser Glu Thr Tyr Val Ala Lys Lys 
        355                 360                 365             


Ala Ile Glu Cys Ala Lys Glu Val Thr Glu Gln Glu Gly Lys Leu Gly 
    370                 375                 380                 


Tyr Ile Asn His Val Gly Phe Tyr Leu Val Gly Lys Gly Arg Ser Ile 
385                 390                 395                 400 


Leu Glu Asn Lys Leu Ser Asn Lys Ser Lys Arg Thr Ile Ser Trp Arg 
                405                 410                 415     


Lys Ile Ala Lys Lys Ser Pro Glu Thr Leu Tyr Val Gly Leu Ile Leu 
            420                 425                 430         


Ile Phe Leu Leu Val Glu Glu Phe Phe Ala Leu Lys Tyr Ile Ala Asn 
        435                 440                 445             


Phe Ser Asn Lys Trp Gly Leu Leu Phe Ile Ser Gly Val Ile Leu Leu 
    450                 455                 460                 


Ile Pro Phe Ser Glu Met Ser Val Gln Leu Val Asn Trp Ile Leu Val 
465                 470                 475                 480 


His Ile Phe Lys Pro Val Val Leu Pro Lys Ile Glu Leu Lys Glu Gly 
                485                 490                 495     


Ile Pro Glu Asp Ala Lys Thr Met Val Val Ile Ser Ser Leu Leu Pro 
            500                 505                 510         


Asp Glu Lys Arg Thr Lys Glu Leu Ile Glu Asn Leu Glu Val Tyr Tyr 
        515                 520                 525             


His Ala Asn Arg Glu Lys Asn Leu Tyr Phe Gly Leu Leu Gly Asp Phe 
    530                 535                 540                 


Lys Asp Ala Pro Phe Glu Val Met Ser Glu Asp Glu Lys Ile Val Lys 
545                 550                 555                 560 


Cys Ala Leu Glu Gln Ile Glu Lys Leu Asn Glu Lys Tyr Ser Lys Asn 
                565                 570                 575     


Gly Glu Lys Ile Phe Tyr Tyr Phe His Arg Lys Arg Lys Tyr Asn Gln 
            580                 585                 590         


Met Gln Lys Ser Trp Met Gly Trp Glu Arg Lys Arg Gly Ala Leu Val 
        595                 600                 605             


Glu Phe Asn Glu Leu Leu Arg Gly Lys Glu Asp Thr Ser Phe Tyr Val 
    610                 615                 620                 


Val Ser Gly Asp Val Ala Lys Leu Asn Ile Lys Tyr Val Ile Thr Leu 
625                 630                 635                 640 


Asp Ala Asp Thr Asn Leu Pro Ile Asp Thr Ala Lys Lys Leu Val Gly 
                645                 650                 655     


Thr Met Leu His Pro Leu Asn Lys Ala Val Ile Asp Arg Asp Tyr Gly 
            660                 665                 670         


Val Val Val Glu Gly Tyr Gly Leu Leu Gln Pro Arg Ile Gly Ile Asp 
        675                 680                 685             


Ile Glu Ser Ala Asn Ala Thr Leu Phe Ser Lys Ile Tyr Ala Gly Glu 
    690                 695                 700                 


Gly Gly Ile Asp Pro Tyr Thr Thr Ala Val Ser Asp Val Tyr Gln Asp 
705                 710                 715                 720 


Leu Phe Gly Glu Gly Ile Tyr Thr Gly Lys Gly Ile Tyr Asp Val Asp 
                725                 730                 735     


Val Phe Arg Glu Leu Leu Arg Asp Thr Ile Pro Asp Asn Ser Ile Leu 
            740                 745                 750         


Ser His Asp Leu Leu Glu Gly Ser Phe Val Arg Thr Gly Leu Val Ser 
        755                 760                 765             


Asp Ile Glu Leu Ile Asp Gly Tyr Pro Ala Lys Tyr Asn Ser Tyr Ile 
    770                 775                 780                 


Met Arg Leu His Arg Trp Val Arg Gly Asp Trp Gln Leu Leu Pro Tyr 
785                 790                 795                 800 


Leu Lys Ser Lys Ile Lys Asn Arg Lys Gly Glu Met Val Lys Asn Pro 
                805                 810                 815     


Leu Ser Leu Ile Thr Lys Trp Lys Ile Ile Asp Asn Leu Arg Arg Ser 
            820                 825                 830         


Val Val Ser Val Ala Leu Met Leu Met Leu Phe Leu Gly Phe Ser Leu 
        835                 840                 845             


Leu Pro Gly Ser Ser Phe Leu Trp Leu Gly Val Ala Ile Leu Thr Val 
    850                 855                 860                 


Phe Phe Pro Ile Leu Pro Ala Leu Val Asp Thr Ile Phe Lys Gly Gln 
865                 870                 875                 880 


Phe Arg His Tyr Trp Glu Lys Arg His Lys Ala Val Ile Thr Ser Ile 
                885                 890                 895     


Glu Ala Ala Phe Tyr Gln Ser Leu Leu Asn Phe Ala Phe Leu Pro Tyr 
            900                 905                 910         


Gln Ala Tyr Met Met Ala Asp Ala Ile Val Arg Thr Leu Thr Arg Leu 
        915                 920                 925             


Tyr Ile Thr Arg Lys Asn Leu Leu Glu Trp Val Thr Ala Ala Asp Met 
    930                 935                 940                 


Glu Lys Arg Leu Arg Asn Asp Phe Ala Ser Phe Phe Lys Arg Met Trp 
945                 950                 955                 960 


Ile Val Leu Val Glu Gly Leu Ala Leu Val Ala Leu Val Met Tyr Phe 
                965                 970                 975     


Lys Pro Gln Asp Leu Ile Gly Ala Ile Val Leu Phe Phe Leu Trp Ala 
            980                 985                 990         


Ile Ser Pro Tyr Ile Ala Phe Tyr  Ile Ser Gln Pro Ile  Ile Ser Lys 
        995                 1000                 1005             


Glu Lys  Thr Val Ser Gln Glu  Glu Met Glu Glu Leu  Arg Leu Ile 
    1010                 1015                 1020             


Ala Arg  Lys Thr Trp Arg Phe  Phe Glu Asp Phe Val  Thr Glu Ser 
    1025                 1030                 1035             


Gln Asn  Tyr Leu Pro Pro Asp  Asn Phe Gln Glu Asp  Pro Pro Asn 
    1040                 1045                 1050             


Gly Ile  Ala Glu Arg Thr Ser  Pro Thr Asn Ile Gly  Leu Tyr Leu 
    1055                 1060                 1065             


Val Ser  Val Val Gly Ala Arg  Asp Leu Gly Tyr Ile  Thr Thr Thr 
    1070                 1075                 1080             


Glu Met  Val Glu Arg Ile Lys  Lys Thr Leu Thr Thr  Ile Gly Lys 
    1085                 1090                 1095             


Met Glu  Lys Trp Asn Gly His  Leu Tyr Asn Trp Tyr  Asn Thr Arg 
    1100                 1105                 1110             


Thr Leu  Glu Pro Leu Arg Pro  Tyr Tyr Val Ser Thr  Val Asp Ser 
    1115                 1120                 1125             


Gly Asn  Leu Val Gly Tyr Leu  Ile Thr Val Lys Glu  Ala Ile Gly 
    1130                 1135                 1140             


Glu Phe  Leu Asn Lys Pro Leu  Ile Asp Ile Glu Leu  Ala Lys Gly 
    1145                 1150                 1155             


Leu Lys  Asp Thr Ile Lys Met  Leu Asn Ile Glu Gly  Ile Thr Glu 
    1160                 1165                 1170             


Asp Ile  Phe Arg Asn Ile Leu  Asn Lys Lys Thr Leu  Met Pro Ser 
    1175                 1180                 1185             


Asp Trp  Glu Val Phe Leu Ser  Lys Ile Ser Glu Lys  Leu Ser Ser 
    1190                 1195                 1200             


Thr Glu  Asp Glu Val Gly Asn  Ile Glu Arg Leu Lys  Asn Ile Ile 
    1205                 1210                 1215             


Gly Ala  Leu Lys Arg Glu Met  Lys Glu Phe Leu Ala  Trp Thr Glu 
    1220                 1225                 1230             


Phe Asp  Glu Arg Gln Lys Glu  Gln Glu Ile Phe Lys  Arg Tyr Lys 
    1235                 1240                 1245             


Glu Val  Phe Glu Glu His Ser  Ser Pro Lys Glu Leu  Glu Lys Val 
    1250                 1255                 1260             


Tyr Lys  Asn Tyr Leu Leu Glu  Ile Glu Glu Val Phe  Glu Lys Ala 
    1265                 1270                 1275             


Thr Glu  Glu Glu Lys Ala Leu  Leu Lys Ser Gln Lys  Asp Lys Val 
    1280                 1285                 1290             


Ala Arg  Ala Leu Glu Lys Ile  Lys Asn Leu Glu Ala  Glu Ile Glu 
    1295                 1300                 1305             


Asn Ile  Lys Ser Ile Ile Glu  Asn Leu Val Glu Lys  Thr Glu Phe 
    1310                 1315                 1320             


Arg His  Leu Tyr Asp Glu Lys  Arg Gln Leu Phe Ser  Ile Gly Tyr 
    1325                 1330                 1335             


Asn Val  Glu Glu Glu Lys Leu  Thr Lys Ser Tyr Tyr  Asp Leu Leu 
    1340                 1345                 1350             


Ala Ser  Glu Ala Arg Gln Ala  Ser Phe Ile Ala Ile  Ala Lys Arg 
    1355                 1360                 1365             


Glu Ile  Asp Lys Lys His Trp  Phe Lys Leu Gly Arg  Met Leu Ala 
    1370                 1375                 1380             


Ile Glu  Asn Arg Tyr Lys Gly  Leu Val Ser Trp Ser  Gly Thr Met 
    1385                 1390                 1395             


Phe Glu  Tyr Phe Met Pro Leu  Leu Ile Met Lys Asn  Tyr Gln Asn 
    1400                 1405                 1410             


Thr Leu  Leu Asp Glu Thr Tyr  Ala Phe Ala Val Arg  Val Gln Lys 
    1415                 1420                 1425             


Asn Tyr  Ala Lys Glu Leu Gly  Ile Pro Trp Gly Ile  Ser Glu Ser 
    1430                 1435                 1440             


Gly Phe  Tyr Ala Phe Asp Ile  Asn Leu Asn Tyr Gln  Tyr Lys Ala 
    1445                 1450                 1455             


Phe Gly  Val Pro Ser Leu Gly  Leu Lys Arg Gly Leu  Ser His Asp 
    1460                 1465                 1470             


Lys Val  Val Ala Pro Tyr Gly  Ser Leu Leu Ala Ile  Gly Val Asp 
    1475                 1480                 1485             


Val Glu  Gly Val Leu Gln Asn  Ile Arg Phe Leu Lys  Lys Glu Gly 
    1490                 1495                 1500             


Val Glu  Gly Lys Tyr Gly Phe  Tyr Glu Ala Ile Asp  Tyr Thr Pro 
    1505                 1510                 1515             


Glu Arg  Phe Pro Phe Gly Lys  Lys Ser Ala Ile Val  Lys Ser Phe 
    1520                 1525                 1530             


Met Ala  His His Gln Gly Met  Val Phe Val Ala Leu  Asp Asn Phe 
    1535                 1540                 1545             


Ile Asn  Asn Asn Val Met Gln  Lys Arg Phe His Lys  Asp Pro Arg 
    1550                 1555                 1560             


Ile Lys  Ala Ala Gln Ile Leu  Leu Gln Glu Lys Met  Pro Met Tyr 
    1565                 1570                 1575             


Leu Asp  Ile Thr Arg Glu Glu  Arg Glu Glu Ala Arg  Lys Ile Gln 
    1580                 1585                 1590             


Lys Val  Arg Lys Glu Asp Gly  Asp Phe Val Arg Ile  Leu Gly Glu 
    1595                 1600                 1605             


Ser Lys  Thr Trp Leu Pro Glu  Val His Ile Leu Ser  Ser Gly Arg 
    1610                 1615                 1620             


Tyr Phe  Val Met Leu Thr Glu  Lys Gly Thr Gly Tyr  Ser Lys Asn 
    1625                 1630                 1635             


Ser Arg  Gly Ile Phe Leu Thr  Arg Trp Arg Lys Asp  Leu Ala Gln 
    1640                 1645                 1650             


Asp Phe  Gly Thr Phe Ile Phe  Val Gln Asn Ile Asn  Ser Asn Thr 
    1655                 1660                 1665             


Val Trp  Ser Val Thr Tyr Ala  Pro Phe Tyr Glu Lys  Gly Gln Asn 
    1670                 1675                 1680             


Tyr Arg  Val Val Phe Ser Ala  Asp Lys Ala Glu Tyr  Phe Lys Arg 
    1685                 1690                 1695             


Val Gly  Asn Ile Asp Thr His  Leu Glu Ile Val Ile  Ser Pro Glu 
    1700                 1705                 1710             


Asp Asp  Val Glu Ile Arg Arg  Leu Thr Leu Lys Asn  His Ser Lys 
    1715                 1720                 1725             


His Pro  Arg Ile Leu Glu Val  Thr Ser Phe Gly Glu  Ile Ser Leu 
    1730                 1735                 1740             


Ile Asp  Leu Pro Thr Asp Val  Ala His Pro Ala Phe  Asn Lys Leu 
    1745                 1750                 1755             


Phe Val  Lys Thr Glu Phe Leu  Lys Glu Glu Asp Ala  Ile Leu Val 
    1760                 1765                 1770             


Cys Arg  Lys Pro Arg Glu Gln  Gly Lys Asn Lys Leu  Trp Ala Val 
    1775                 1780                 1785             


His Lys  Val Ala Val Leu Ser  Gly Glu Ile Val Gly  Asp Thr Gln 
    1790                 1795                 1800             


Phe Glu  Thr Asp Arg Ala Lys  Phe Ile Gly Arg Gly  Arg Ser Leu 
    1805                 1810                 1815             


Lys Asn  Pro Ile Ala Leu Glu  Ala Asp Gln Pro Leu  Ser Asn Thr 
    1820                 1825                 1830             


Glu Gly  Ala Val Leu Asp Pro  Ile Val Ser Leu Arg  Lys Arg Val 
    1835                 1840                 1845             


Lys Val  Met Pro Gly Glu Val  Ala Lys Val Val Tyr  Ile Ser Ala 
    1850                 1855                 1860             


Ile Thr  Glu Thr Lys Glu Glu  Ala Ile Lys Ile Ala  Ala Lys Tyr 
    1865                 1870                 1875             


Lys Glu  Glu Asn Val Val Glu  Arg Asp Phe Glu Met  Ser Trp Thr 
    1880                 1885                 1890             


Arg Ser  Arg Val Glu Leu Asp  Tyr Leu Asn Leu Lys  Pro Arg Glu 
    1895                 1900                 1905             


Leu Gly  Leu Leu Gln Arg Met  Leu Ala His Ile Leu  Phe Val Ser 
    1910                 1915                 1920             


Pro Gln  Arg Arg Tyr Arg Glu  Glu Met Ile Leu Lys  Asn Val Lys 
    1925                 1930                 1935             


Gly Gln  Ser Gly Leu Trp Ala  Tyr Gly Ile Ser Gly  Asp Leu Pro 
    1940                 1945                 1950             


Ile Val  Leu Val Glu Ile Glu  Lys Met Glu Glu Ile  Glu Met Val 
    1955                 1960                 1965             


Lys Trp  Phe Leu Lys Ala Tyr  Glu Tyr Trp Lys Met  Lys Gly Ile 
    1970                 1975                 1980             


Asn Ile  Asp Leu Val Ile Leu  Asn Lys Asp Lys Ser  Gly Tyr Leu 
    1985                 1990                 1995             


Gln Pro  Leu His Asp Lys Ile  Lys Glu Leu Ile Asn  Thr Thr Phe 
    2000                 2005                 2010             


Ser Tyr  Asp Ile Phe Gly Lys  Tyr Gly Gly Val Tyr  Leu Leu Gln 
    2015                 2020                 2025             


Gln Asn  Asn Leu Lys Glu Glu  Asp Val Tyr Leu Leu  Asn Thr Val 
    2030                 2035                 2040             


Val Ala  Leu Lys Phe Glu Gly  Gly Asn Glu Ser Ile  Tyr Asp Gln 
    2045                 2050                 2055             


Ile Met  Ile Lys Glu Thr Lys  Asn Ala Pro Lys Leu  Lys Asn Trp 
    2060                 2065                 2070             


Val Lys  Lys Val Gln Asn Phe  Glu Glu Ile Lys Leu  Glu Glu Leu 
    2075                 2080                 2085             


Pro Leu  Asp Tyr Tyr Asn Gly  Phe Gly Gly Phe Ser  Tyr Asp Gly 
    2090                 2095                 2100             


Lys Glu  Tyr Ile Ile Lys Trp  Glu Gly Lys Ser Thr  Pro Ala Pro 
    2105                 2110                 2115             


Trp Ile  Asn Val Ile Ser Asn  Pro Ser Phe Gly Phe  Gln Val Ser 
    2120                 2125                 2130             


Glu Thr  Gly Ala Gly Tyr Thr  Trp Ala Glu Asn Ser  Arg Glu Tyr 
    2135                 2140                 2145             


Lys Leu  Thr Pro Trp Tyr Asn  Asp Pro Val Leu Asp  Pro His Gly 
    2150                 2155                 2160             


Glu Val  Ile Tyr Leu Thr Asp  Glu Glu Thr Gly Asp  Arg Trp Ser 
    2165                 2170                 2175             


Ile Thr  Pro Leu Pro Ala Gly  Lys Ala Lys Val His  Tyr Ile Lys 
    2180                 2185                 2190             


His Gly  Phe Gly Tyr Thr Ser  Phe Glu Thr Ile Cys  Cys Gly Leu 
    2195                 2200                 2205             


Ser Gln  His Leu Lys Met Phe  Val Ala Lys Glu Asp  Ser Ile Lys 
    2210                 2215                 2220             


Ile Asn  Leu Val Thr Ile Lys  Asn Leu Gly Asn Glu  Asn Arg Lys 
    2225                 2230                 2235             


Leu Thr  Val Ser Tyr Tyr Ile  Arg Pro Val Leu Gly  Val Thr Asp 
    2240                 2245                 2250             


Glu Ile  Thr Ser Pro Tyr Leu  Phe Thr Lys Tyr Asp  Glu Lys Ile 
    2255                 2260                 2265             


Gly Ala  Leu Met Ile Lys Asn  Val Tyr Asn Glu Asp  Phe Thr Asn 
    2270                 2275                 2280             


Arg Leu  Ala Phe Leu Ser Ala  Ser Glu Lys Ile Asn  Ser Phe Thr 
    2285                 2290                 2295             


Cys Asp  Arg Ser Glu Phe Ile  Gly Val Ala Ser Ser  Leu Thr Ser 
    2300                 2305                 2310             


Pro Gln  Ala Leu Glu Tyr Glu  Thr Leu Ser Asn Ser  Thr Gly Ile 
    2315                 2320                 2325             


Ser Leu  Asp Pro Cys Ala Ala  Ile Gln Phe His Val  Glu Val Lys 
    2330                 2335                 2340             


Ala Tyr  Glu Glu Lys Gln Phe  Ala Ile Leu Leu Gly  His Gly Lys 
    2345                 2350                 2355             


Asn Glu  Glu Glu Val Ala Arg  Leu Ile Ser Lys Tyr  Thr Asn Val 
    2360                 2365                 2370             


Glu Asn  Cys Lys Asn Glu Leu  Gln Arg Val Lys Glu  Phe Trp Gln 
    2375                 2380                 2385             


Tyr Leu  Leu Gly Arg Ile Gln  Val Lys Thr Pro Asp  Arg Ser Met 
    2390                 2395                 2400             


Asp Leu  Leu Val Asn Gly Trp  Leu Pro Tyr Gln Thr  Ile Ala Cys 
    2405                 2410                 2415             


Arg Leu  Trp Ala Arg Ser Ala  Phe Tyr Gln Ser Gly  Gly Ala Tyr 
    2420                 2425                 2430             


Gly Phe  Arg Asp Gln Leu Gln  Asp Ala Met Asn Met  Val Tyr Leu 
    2435                 2440                 2445             


Glu Pro  Glu Phe Thr Lys Asn  Gln Ile Val Asn Ala  Cys Gln His 
    2450                 2455                 2460             


Gln Phe  Val Glu Gly Asp Val  Gln His Trp Trp His  Pro Val Leu 
    2465                 2470                 2475             


Asn Lys  Gly Ile Arg Thr Lys  Phe Ala Asp Asp Leu  Leu Trp Leu 
    2480                 2485                 2490             


Pro Tyr  Val Thr Ala Asp Tyr  Ile Glu Lys Thr Gly  Asp Trp Pro 
    2495                 2500                 2505             


Ile Leu  Asp Ile Glu Val Asn  Tyr Leu Glu Asp Leu  Arg Leu Lys 
    2510                 2515                 2520             


Glu Glu  Glu Glu Glu Arg Tyr  Ser Thr Pro Arg Ile  Ser Glu Thr 
    2525                 2530                 2535             


Lys Gly  Thr Val Tyr Glu His  Cys Ile Arg Ala Ile  Asp Tyr Ser 
    2540                 2545                 2550             


Leu Lys  Phe Gly Glu His Gly  Leu Pro Leu Met Gly  Ala Gly Asp 
    2555                 2560                 2565             


Trp Asn  Asp Gly Met Asn Lys  Val Gly Asn Lys Gly  Lys Gly Glu 
    2570                 2575                 2580             


Ser Val  Trp Leu Gly Trp Phe  Leu Tyr Thr Ile Leu  Gln Lys Phe 
    2585                 2590                 2595             


Ser Pro  Ile Cys Gln Thr Lys  Lys Asp Glu Glu His  Ala Lys Lys 
    2600                 2605                 2610             


Tyr Gln  Glu Ile Ala Asn Lys  Leu Ile Lys Ala Ile  Glu Glu Asn 
    2615                 2620                 2625             


Ala Trp  Asp Gly Ser Trp Tyr  Arg Arg Ala Tyr Phe  Asp Asp Gly 
    2630                 2635                 2640             


Thr Pro  Leu Gly Ser Val Asp  Asn Ser Glu Cys Lys  Ile Asp Ser 
    2645                 2650                 2655             


Ile Ser  Gln Ser Trp Ser Val  Ile Ser Lys Ala Gly  Lys Glu Val 
    2660                 2665                 2670             


Arg Val  Lys Glu Ala Met Lys  Ala Val Val Asn Tyr  Leu Val Asn 
    2675                 2680                 2685             


Glu Glu  Glu Gly Ile Ile Lys  Leu Leu Thr Pro Pro  Phe Asp Asn 
    2690                 2695                 2700             


Gly Asp  Leu Asn Pro Gly Tyr  Ile Lys Gly Tyr Val  Pro Gly Val 
    2705                 2710                 2715             


Arg Glu  Asn Gly Gly Gln Tyr  Thr His Ala Ala Ala  Trp Val Ile 
    2720                 2725                 2730             


Leu Ala  Phe Ala Glu Leu Gly  Glu Gly Asp Arg Ala  Trp Gln Leu 
    2735                 2740                 2745             


Tyr Asn  Met Val Asn Pro Ile  Asn His Thr Arg Thr  Pro Ile Glu 
    2750                 2755                 2760             


Cys Met  Lys Tyr Lys Val Glu  Pro Tyr Val Met Ala  Ala Asp Val 
    2765                 2770                 2775             


Tyr Ala  Val Glu Pro His Val  Gly Arg Gly Gly Trp  Thr Trp Tyr 
    2780                 2785                 2790             


Thr Gly  Ala Ala Gly Trp Met  Tyr Arg Ile Ala Ile  Glu Asn Leu 
    2795                 2800                 2805             


Leu Gly  Leu Lys Lys Tyr Gly  Glu Lys Leu Ile Ile  Asp Pro Cys 
    2810                 2815                 2820             


Ile Pro  Lys Asn Trp Asp Lys  Tyr Val Ile Glu Tyr  Asn Tyr Lys 
    2825                 2830                 2835             


Asn Thr  Lys Tyr Leu Ile Glu  Val Arg Asn Pro Glu  Gly Val Asn 
    2840                 2845                 2850             


Lys Gly  Val Lys Glu Val Tyr  Ile Asp Gly Glu Leu  Val Thr Asp 
    2855                 2860                 2865             


Lys Thr  Ile Asp Leu Thr Lys  Glu Gly Asn Gly His  Gln Val Leu 
    2870                 2875                 2880             


Val Ile  Met Gly 
    2885         


<210>  205
<211>  2862
<212>  PRT
<213>  Thermoanaerobacter tengcongensis

<400>  205

Met Trp Tyr Ala Val Phe Val Leu Ile Leu Leu Leu Ala Gly Ile Tyr 
1               5                   10                  15      


Leu Lys Ser Lys Lys Ile Glu Val Asp Asp Ser Met Arg Glu Phe Asp 
            20                  25                  30          


Asp Ile Ile Leu Ser Ser Glu Glu Met Glu Lys His Ala Glu Glu Leu 
        35                  40                  45              


Ala Gln Asn His Val Ile Ala Asn Arg Asn Arg Ala Ser Phe Leu Leu 
    50                  55                  60                  


Ile Pro Arg Met Asn Lys Asn Tyr Glu Tyr Ile Lys Ser Val Tyr Arg 
65                  70                  75                  80  


Ser Leu Asn Asn Leu Leu Lys Glu Lys Asp Thr Tyr Ile Ser Gln Glu 
                85                  90                  95      


Glu Glu Trp Leu Leu Asp Asn Phe Tyr Ile Ile Glu Glu Gln Val Lys 
            100                 105                 110         


Glu Ile Arg Lys Ser Leu Ser Lys Lys Tyr Tyr Ala Gly Leu Pro Val 
        115                 120                 125             


Leu Lys Asn Gly Ala Phe Arg Gly Tyr Pro Arg Val Tyr Ala Leu Ala 
    130                 135                 140                 


Phe Glu Leu Val Leu His Thr Asp Gly Lys Ile Glu Glu Lys Gly Ile 
145                 150                 155                 160 


Ile Asn Phe Ile Lys Ala Tyr Gln Lys Lys Ala Leu Leu Thr Thr Ser 
                165                 170                 175     


Glu Leu Trp Ala Leu Ser Leu Met Ile Arg Ile Ala Leu Ile Glu Lys 
            180                 185                 190         


Ile Lys Lys Val Cys Glu Glu Ile Val Glu Ser Arg Leu Gln Arg Glu 
        195                 200                 205             


Lys Ala Glu Lys Met Leu Ser Ala Leu Met Glu Lys Glu Met Ser Tyr 
    210                 215                 220                 


Glu Glu Val Lys Lys Leu Ile Lys Ser Asn Ile Lys Val Val Asp Arg 
225                 230                 235                 240 


Phe Pro Leu Gln Phe Val Glu Tyr Leu Val Ser Arg Ile Lys Arg Glu 
                245                 250                 255     


Gly Ser Asn Ser Ser Asp Ile Leu Lys Thr Leu Glu Lys Ile Leu Met 
            260                 265                 270         


Glu Tyr Asp Ser Ser Ile Asn Asp Ile Ala Glu Lys Ala His Tyr Phe 
        275                 280                 285             


Gln Ala Lys Arg Gln Val Ser Ile Gly Asn Ala Ile Val Ser Leu Lys 
    290                 295                 300                 


Thr Val Ser Ser Leu Asp Trp Ala Glu Ile Phe Glu Thr Leu Ser Pro 
305                 310                 315                 320 


Val Glu Gln Val Leu Lys Gln Asp Pro Asp Gly Thr Tyr Pro Lys Met 
                325                 330                 335     


Asp Phe Glu Ser Lys Asp Tyr Tyr Arg His Glu Ile Glu Lys Leu Ala 
            340                 345                 350         


Arg Tyr Tyr Asn Val Ser Glu Thr Tyr Val Ala Lys Lys Ala Val Glu 
        355                 360                 365             


Cys Ala Arg Glu Val Ala Asp Gln Gly Glu Asn Leu Gly Tyr Ile Asn 
    370                 375                 380                 


His Val Gly Phe Tyr Leu Ile Gly Lys Gly Arg Ser Ile Leu Glu Ser 
385                 390                 395                 400 


Lys Leu Asn Asn Lys Lys Arg Arg Phe Phe Asp Phe Tyr Arg Ile Arg 
                405                 410                 415     


Gln Lys Asn Pro Ala Thr Val Tyr Phe Gly Leu Ile Ile Leu Phe Phe 
            420                 425                 430         


Ala Leu Gly Glu Ile Ile Ser Leu Gly Tyr Leu Arg His Phe Thr Gly 
        435                 440                 445             


Ser Phe Trp Asn Leu Phe Ala Ser Ser Leu Val Leu Ala Ile Pro Leu 
    450                 455                 460                 


Ser Glu Ile Ser Ile Gln Met Thr Asn Trp Val Leu Met His Ile Phe 
465                 470                 475                 480 


Lys Pro Val Met Leu Pro Lys Ile Glu Leu Lys Asp Gly Ile Pro Asp 
                485                 490                 495     


Asp Ala Lys Thr Phe Val Val Ile Ser Ser Leu Leu Pro Asp Glu Lys 
            500                 505                 510         


Lys Ala Lys Glu Leu Val Glu Asn Leu Glu Val Tyr Tyr His Ala Asn 
        515                 520                 525             


Arg Glu Arg Asn Leu Tyr Phe Gly Ile Leu Gly Asp Phe Lys Asp Ala 
    530                 535                 540                 


Pro Leu Glu Val Met Pro Glu Asp Glu Lys Ile Val Lys Ala Thr Leu 
545                 550                 555                 560 


Glu Glu Ile Glu Lys Leu Asn Glu Lys Tyr Ala Glu Asn Gly Glu Lys 
                565                 570                 575     


Val Phe Tyr Tyr Phe His Arg Lys Arg Ile Tyr Asn Glu Met Gln Lys 
            580                 585                 590         


Ser Trp Met Gly Trp Glu Arg Lys Arg Gly Ala Leu Met Glu Phe Val 
        595                 600                 605             


Asp Leu Leu Arg Gly Glu Lys Asp Thr Thr Phe Tyr Ile Val Ser Asp 
    610                 615                 620                 


Asp Val Ser Lys Leu Gly Ile Lys Tyr Val Ile Thr Leu Asp Ala Asp 
625                 630                 635                 640 


Thr Asn Leu Pro Ile Asp Thr Ala Lys Lys Leu Val Gly Ala Met Leu 
                645                 650                 655     


His Pro Leu Asn Arg Ala Ile Ile Asp Arg Asp Glu Gly Ile Val Val 
            660                 665                 670         


Glu Gly Tyr Gly Leu Leu Gln Pro Arg Ile Gly Val Asp Ile Glu Ser 
        675                 680                 685             


Ala Asn Ala Ser Leu Phe Ser Lys Ile Tyr Gly Gly Glu Gly Gly Ile 
    690                 695                 700                 


Asp Pro Tyr Thr Thr Ala Thr Ser Asp Ile Tyr Gln Asp Leu Phe Gly 
705                 710                 715                 720 


Glu Gly Ile Tyr Thr Gly Lys Gly Ile Phe Asp Val Asp Val Phe Arg 
                725                 730                 735     


Glu Leu Leu Lys Asp Thr Ile Pro Asp Asn Ser Ile Leu Ser His Asp 
            740                 745                 750         


Leu Leu Glu Gly Ser Phe Val Arg Thr Gly Leu Val Thr Asp Ile Glu 
        755                 760                 765             


Leu Ile Asp Gly Phe Pro Ala Lys Tyr Asn Ser Tyr Met Met Arg Leu 
    770                 775                 780                 


His Arg Trp Val Arg Gly Asp Trp Gln Leu Leu Pro Tyr Leu Arg Ser 
785                 790                 795                 800 


Lys Ile Arg Asn Arg Arg Gly Glu Leu Ile Arg Asn Pro Leu Ser Leu 
                805                 810                 815     


Ile Thr Lys Trp Lys Ile Met Asp Asn Leu Arg Arg Ser Leu Ile Ser 
            820                 825                 830         


Ile Ser Leu Ile Val Met Leu Phe Leu Gly Phe Ser Ala Leu Pro Ala 
        835                 840                 845             


Ser Ala Leu Phe Trp Val Ala Val Ala Ala Leu Thr Val Phe Phe Pro 
    850                 855                 860                 


Val Met Pro Ala Leu Phe Asp Leu Ile Phe Arg Gly Gln Leu Arg Gln 
865                 870                 875                 880 


Tyr Leu Glu Lys Arg His Arg Ala Val Ile Thr Gly Val Glu Val Ala 
                885                 890                 895     


Phe Tyr Gln Ala Leu Leu Asn Phe Ile Phe Leu Pro Tyr Asn Ala Tyr 
            900                 905                 910         


Ile Met Ala Asp Ala Ile Ile Arg Thr Ile Ser Arg Met Tyr Ile Thr 
        915                 920                 925             


Lys Arg Asn Leu Leu Glu Trp Val Thr Ala Ala Asp Met Glu Lys Arg 
    930                 935                 940                 


Leu Lys Asn Asp Phe Ile Ser Phe Val Lys Arg Met Trp Val Val Leu 
945                 950                 955                 960 


Leu Lys Gly Val Val Leu Ile Leu Leu Thr Ala Tyr Phe Lys Pro Gly 
                965                 970                 975     


Ala Leu Ile Phe Ala Val Gly Val Phe Phe Leu Trp Ala Phe Ser Pro 
            980                 985                 990         


Tyr Val Ala Phe Tyr Ile Ser Gln  Pro Val Leu Leu Lys  Ile Lys Phe 
        995                 1000                 1005             


Ile Leu  Asp Glu Asp Ile Glu  Glu Val Arg Leu Ile  Ala Arg Lys 
    1010                 1015                 1020             


Thr Trp  Lys Phe Phe Glu Asp  Thr Val Thr Glu Ala  Gln Asn Tyr 
    1025                 1030                 1035             


Leu Pro  Pro Asp Asn Phe Gln  Glu Asp Pro Pro Asn  Gly Ile Ala 
    1040                 1045                 1050             


Glu Arg  Thr Ser Pro Thr Asn  Ile Gly Leu Tyr Leu  Val Ser Thr 
    1055                 1060                 1065             


Val Gly  Ala Arg Asp Leu Gly  Tyr Ile Thr Thr Ser  Glu Met Val 
    1070                 1075                 1080             


Asp Arg  Ile Glu Asn Thr Ile  Asn Thr Ile Lys Lys  Met Glu Lys 
    1085                 1090                 1095             


Trp Asn  Gly His Leu Phe Asn  Trp Tyr Asp Thr Arg  Thr Leu Lys 
    1100                 1105                 1110             


Pro Leu  Arg Pro Tyr Tyr Val  Ser Thr Val Asp Ser  Gly Asn Leu 
    1115                 1120                 1125             


Val Gly  Tyr Leu Ile Thr Val  Lys Glu Ala Leu Glu  Glu Phe Leu 
    1130                 1135                 1140             


Asp Lys  Pro Val Ile Asp Leu  Glu Phe Leu Arg Gly  Leu Lys Asp 
    1145                 1150                 1155             


Thr Val  Arg Met Leu Lys Ile  Glu Arg Ile Asp Lys  Ser Leu Phe 
    1160                 1165                 1170             


Glu Glu  Phe Leu Lys Lys Gly  Asp Ile Asp Pro Leu  Ala Trp Lys 
    1175                 1180                 1185             


Lys Ile  Leu Asp Asp Leu Glu  Glu Val Glu Glu Glu  Arg Leu Arg 
    1190                 1195                 1200             


Asp Ile  Val Lys Lys Phe Lys  Asn Glu Ile Arg Glu  Phe Met Pro 
    1205                 1210                 1215             


Trp Leu  Glu Phe Glu Asp Ala  Glu Gly Gly Tyr Gly  Glu Ile Phe 
    1220                 1225                 1230             


Asn Glu  Cys Asn Ser Phe Glu  Glu Leu Lys Lys Val  Tyr Glu Lys 
    1235                 1240                 1245             


Tyr Leu  Glu Glu Thr Phe Arg  Ala Lys Lys Glu Gly  Leu Pro Glu 
    1250                 1255                 1260             


Phe Lys  Ile Lys Gln Ile Gln  Arg Ala Val Glu Lys  Ile Glu Glu 
    1265                 1270                 1275             


Leu Lys  Glu Arg Ile Leu Lys  Leu Lys Gln Glu Ile  Glu Asp Ile 
    1280                 1285                 1290             


Ile Glu  Lys Thr Glu Phe Lys  His Leu Tyr Asp Glu  Lys Arg Gln 
    1295                 1300                 1305             


Leu Phe  Ser Ile Gly Tyr Asn  Val Glu Glu Glu Lys  Leu Thr Lys 
    1310                 1315                 1320             


Ser Tyr  Tyr Asp Leu Leu Ala  Ser Glu Ala Arg Gln  Ala Ser Phe 
    1325                 1330                 1335             


Ile Ala  Ile Ala Lys Arg Glu  Val Asp Lys Lys His  Trp Phe Lys 
    1340                 1345                 1350             


Leu Gly  Arg Met Leu Thr Arg  Ala Asn Arg Ser Lys  Gly Leu Val 
    1355                 1360                 1365             


Ser Trp  Ser Gly Thr Met Phe  Glu Tyr Phe Met Pro  Leu Leu Ile 
    1370                 1375                 1380             


Met Lys  Asn Tyr Glu Asn Thr  Leu Leu Asp Glu Thr  Tyr Ser Phe 
    1385                 1390                 1395             


Ala Ala  Lys Val Gln Lys Glu  Tyr Gly Val Lys Leu  Gly Ile Pro 
    1400                 1405                 1410             


Trp Gly  Ile Ser Glu Ser Gly  Phe Tyr Ala Phe Asp  Met Ser Leu 
    1415                 1420                 1425             


Asn Tyr  Gln Tyr Lys Ala Phe  Gly Val Pro Ile Leu  Gly Leu Lys 
    1430                 1435                 1440             


Arg Gly  Leu Ser His Asp Lys  Val Val Ala Pro Tyr  Gly Ser Ile 
    1445                 1450                 1455             


Leu Ala  Ile Ser Val Asp Pro  Glu Gly Val Met Lys  Asn Ile Glu 
    1460                 1465                 1470             


Phe Leu  Lys Lys Glu Gly Ala  Glu Gly Glu Tyr Gly  Leu Tyr Glu 
    1475                 1480                 1485             


Ala Ile  Asp Tyr Thr Pro Glu  Arg Val Pro Phe Gly  Lys Lys Asn 
    1490                 1495                 1500             


Ala Ile  Val Lys Ser Phe Met  Ala His His Gln Gly  Met Ile Phe 
    1505                 1510                 1515             


Val Ala  Ile Asp Asn Phe Ile  His Glu Asn Ile Met  Gln Lys Arg 
    1520                 1525                 1530             


Phe His  Arg Asp Pro Arg Val  Lys Ala Thr Gln Ile  Leu Leu Gln 
    1535                 1540                 1545             


Glu Lys  Ala Pro Ile Tyr Leu  Asp Met Thr Arg Glu  Glu Arg Glu 
    1550                 1555                 1560             


Glu Pro  Arg Lys Ile Gln Lys  Ile Arg Lys Glu Asp  Leu Asp Phe 
    1565                 1570                 1575             


Val Arg  Val Leu Gly Glu Ser  Arg Ser Trp Ile Pro  Glu Val His 
    1580                 1585                 1590             


Ile Val  Ser Ser Gly Lys Tyr  Phe Val Met Leu Thr  Glu Lys Gly 
    1595                 1600                 1605             


Thr Gly  Tyr Ser Lys Asn Ile  Lys Gly Ile Phe Leu  Asn Arg Trp 
    1610                 1615                 1620             


Arg Lys  Asp Ile Ala Gln Asp  Tyr Gly Thr Phe Ile  Phe Ile Arg 
    1625                 1630                 1635             


Asn Val  Asp Ser Asn Glu Val  Trp Ser Ala Thr Phe  Ala Pro Phe 
    1640                 1645                 1650             


Tyr Gln  Lys Gly Gln His Tyr  Arg Val Val Phe Ser  Ala Asp Lys 
    1655                 1660                 1665             


Ala Glu  Tyr Phe Lys Arg Val  Gly Gly Ile Asp Ser  Tyr Leu Glu 
    1670                 1675                 1680             


Ile Thr  Val Ser Pro Glu Asp  Asp Val Glu Ile Arg  Arg Leu Thr 
    1685                 1690                 1695             


Leu Lys  Asn His Ser Lys Tyr  Pro Gln Ile Leu Glu  Ile Thr Ser 
    1700                 1705                 1710             


Phe Ser  Glu Ile Ser Leu Met  Asp Leu Pro Ser Asp  Val Ala His 
    1715                 1720                 1725             


Pro Ala  Phe Asn Lys Leu Phe  Val Lys Thr Glu Phe  Leu Lys Asp 
    1730                 1735                 1740             


Glu Asp  Ala Ile Ile Val Cys  Arg Arg Pro Arg Asp  Pro Glu Lys 
    1745                 1750                 1755             


Ser Arg  Leu Trp Ala Leu His  Lys Val Val Val Leu  Ser Gly Glu 
    1760                 1765                 1770             


Ala Met  Gly Asp Thr Gln Phe  Glu Thr Asp Arg Leu  Lys Phe Ile 
    1775                 1780                 1785             


Gly Arg  Gly Arg Ser Val Arg  Lys Pro Leu Ala Leu  Glu Pro Asp 
    1790                 1795                 1800             


Gln Pro  Leu Ser Asn Thr Glu  Gly Ala Val Leu Asp  Pro Ile Val 
    1805                 1810                 1815             


Ser Leu  Arg Lys Arg Ile Arg  Ile Met Pro Gly Gly  Val Ala Lys 
    1820                 1825                 1830             


Ile Ala  Tyr Ile Ser Ala Ile  Thr Glu Thr Lys Glu  Glu Ala Val 
    1835                 1840                 1845             


Lys Ile  Val Ser Lys Tyr Lys  Glu Glu Asn Ala Ile  Glu Arg Ala 
    1850                 1855                 1860             


Phe Glu  Met Ser Trp Thr Arg  Ser Arg Val Glu Leu  Glu Tyr Ile 
    1865                 1870                 1875             


Asn Leu  Lys Pro Arg Glu Leu  Gly Leu Phe Gln Arg  Met Leu Pro 
    1880                 1885                 1890             


Tyr Leu  Ile Phe Ala Ser Pro  Gln Arg Lys Met Arg  Glu Glu Met 
    1895                 1900                 1905             


Ile Leu  Lys Asn Thr Lys Gly  Gln Ser Gly Leu Trp  Ala His Gly 
    1910                 1915                 1920             


Ile Ser  Gly Asp Leu Pro Ile  Val Leu Leu Glu Val  Glu Lys Met 
    1925                 1930                 1935             


Glu Glu  Ile Glu Leu Val Lys  Trp Phe Leu Lys Ala  Tyr Glu Tyr 
    1940                 1945                 1950             


Trp Arg  Met Lys Gly Ile Asn  Ile Asp Leu Val Ile  Val Asn Lys 
    1955                 1960                 1965             


Asp Lys  Ser Gly Tyr Leu Gln  Pro Leu Asn Asp Lys  Ile Lys Glu 
    1970                 1975                 1980             


Val Ile  Asn Thr Thr Phe Ala  Tyr Asp Val Phe Gly  Lys Tyr Gly 
    1985                 1990                 1995             


Gly Val  Tyr Leu Leu Gln Glu  Asn Asn Leu Lys Glu  Asp Asp Phe 
    2000                 2005                 2010             


Tyr Leu  Leu Asn Ala Val Ala  Ala Leu Lys Phe Asp  Gly Lys Asn 
    2015                 2020                 2025             


Glu Ser  Ile Tyr Asp Gln Ile  Met Val Lys Val His  Lys Lys Ala 
    2030                 2035                 2040             


Leu Lys  Pro Arg Ser Phe Gln  Glu Lys Val Ser Ser  Cys Arg Asp 
    2045                 2050                 2055             


Asp Gly  Leu Glu Glu Ile Glu  Leu Gln Tyr Tyr Asn  Gly Phe Gly 
    2060                 2065                 2070             


Gly Phe  Thr Pro Asp Gly Lys  Glu Tyr Val Ile Lys  Trp Glu Gly 
    2075                 2080                 2085             


Lys Ser  Ser Pro Ala Pro Trp  Ile Asn Ile Ile Ser  Asn Pro Asn 
    2090                 2095                 2100             


Phe Gly  Phe Gln Val Ser Glu  Val Gly Ala Gly Tyr  Thr Trp Ala 
    2105                 2110                 2115             


Glu Asn  Ser Arg Glu Tyr Lys  Leu Thr Pro Trp Tyr  Asn Asp Pro 
    2120                 2125                 2130             


Val Leu  Asp Pro His Gly Glu  Val Ile Tyr Leu Ile  Asp Glu Ile 
    2135                 2140                 2145             


Thr Gly  Glu Lys Trp Thr Ile  Thr Pro His Pro Ala  Gly Asn Ser 
    2150                 2155                 2160             


Gly Ile  Tyr Tyr Ile Arg His  Gly Phe Gly Tyr Ser  Thr Phe Glu 
    2165                 2170                 2175             


Ser Ala  Ser Cys Glu Leu Lys  Ser Arg Leu Thr Met  Phe Val Pro 
    2180                 2185                 2190             


Lys Glu  Asp Ser Val Lys Ile  Asn Leu Ile Lys Leu  Lys Asn Thr 
    2195                 2200                 2205             


Ser Lys  Asn Ser Arg Lys Ile  Gln Ile Val Tyr Tyr  Ile Arg Pro 
    2210                 2215                 2220             


Val Leu  Gly Val Thr Asp Glu  Ala Thr Ser Gln Tyr  Ile Ala Ser 
    2225                 2230                 2235             


Glu Phe  Asp Lys Glu Glu Arg  Ile Leu Tyr Ile Arg  Asn Val Tyr 
    2240                 2245                 2250             


Asn Glu  Asp Phe Val Asn Arg  Ile Ala Phe Leu Ala  Thr Ser Glu 
    2255                 2260                 2265             


Gly Ile  Asn Ser Tyr Glu Ser  Glu Arg Gly Glu Phe  Ile Gly Val 
    2270                 2275                 2280             


Gly Phe  Asp Leu Ser Ser Pro  Gln Ala Leu Ser Tyr  Glu Thr Leu 
    2285                 2290                 2295             


Ser Asn  Ser Glu Gly Leu Ala  Val Asp Pro Cys Ser  Ala Ile Glu 
    2300                 2305                 2310             


Phe Ser  Val Glu Ile Gly Pro  Gly Glu Glu Lys Glu  Ile Ser Ile 
    2315                 2320                 2325             


Leu Leu  Gly His Ala Lys Glu  Lys Lys Glu Ala Lys  Asp Leu Val 
    2330                 2335                 2340             


Leu Lys  Tyr Leu Lys Val Glu  Asn Cys Lys Lys Glu  Leu Glu Lys 
    2345                 2350                 2355             


Val Lys  Gly Phe Trp Gly Glu  Ile Leu Gly Lys Leu  Thr Val Asn 
    2360                 2365                 2370             


Thr Pro  Asp Lys Ser Leu Asp  Leu Leu Val Asn Gly  Trp Leu Pro 
    2375                 2380                 2385             


Tyr Gln  Thr Ile Ala Cys Arg  Leu Trp Ala Arg Ser  Ala Phe Tyr 
    2390                 2395                 2400             


Gln Ser  Gly Gly Ala Tyr Gly  Phe Arg Asp Gln Leu  Gln Asp Ala 
    2405                 2410                 2415             


Met Asn  Met Val Leu Leu Asn  Pro Glu Phe Thr Lys  Arg Gln Ile 
    2420                 2425                 2430             


Ile Asn  Ala Cys Glu His Gln  Phe Ile Glu Gly Asp  Val Gln His 
    2435                 2440                 2445             


Trp Trp  His Pro Val Leu Asn  Lys Gly Ile Arg Thr  Lys Phe Ser 
    2450                 2455                 2460             


Asp Asp  Leu Leu Trp Leu Pro  Tyr Val Val Ala Asp  Tyr Leu Glu 
    2465                 2470                 2475             


Lys Thr  Glu Asp Trp Ala Ile  Leu Glu Glu Lys Ala  Gly Tyr Leu 
    2480                 2485                 2490             


Glu Asp  Leu Pro Leu Lys Glu  Glu Glu Glu Glu Arg  Tyr Ser Val 
    2495                 2500                 2505             


Pro Ser  Ile Ser Ser His Lys  Gly Thr Val Tyr Glu  His Cys Val 
    2510                 2515                 2520             


Lys Ala  Ile Asp Tyr Ala Leu  Lys Phe Gly Glu His  Gly Leu Pro 
    2525                 2530                 2535             


Leu Ile  Gly Thr Gly Asp Trp  Asn Asp Gly Met Asn  Lys Val Gly 
    2540                 2545                 2550             


His Arg  Gly Lys Gly Glu Ser  Val Trp Leu Gly Trp  Phe Leu Tyr 
    2555                 2560                 2565             


Thr Val  Leu Lys Lys Phe Ala  Ser Ile Ser Glu Lys  Met Gly Asp 
    2570                 2575                 2580             


Ile Glu  Arg Lys Glu Lys Tyr  Ile Lys Glu Ala Glu  Arg Leu Leu 
    2585                 2590                 2595             


Lys Ser  Ile Glu Glu Asn Ala  Trp Asp Gly Ser Trp  Tyr Lys Arg 
    2600                 2605                 2610             


Ala Tyr  Phe Asp Asp Gly Thr  Pro Leu Gly Ser Ile  Asn Asn Leu 
    2615                 2620                 2625             


Glu Cys  Lys Ile Asp Ser Ile  Ser Gln Ser Trp Ala  Leu Ile Ser 
    2630                 2635                 2640             


Lys Gly  Gly Arg Ile Glu Arg  Ala Lys Glu Ala Met  Lys Ala Val 
    2645                 2650                 2655             


Val Asn  Tyr Leu Val Asn Glu  Glu Glu Gly Ile Ile  Lys Leu Leu 
    2660                 2665                 2670             


Thr Pro  Pro Phe Asp Ser Gly  Asp Leu Asn Pro Gly  Tyr Ile Lys 
    2675                 2680                 2685             


Gly Tyr  Val Pro Gly Val Arg  Glu Asn Gly Gly Gln  Tyr Thr His 
    2690                 2695                 2700             


Ala Ala  Ala Trp Val Ile Leu  Ala Phe Thr Glu Leu  Gly Asp Gly 
    2705                 2710                 2715             


Asp Thr  Ala Trp Lys Leu Tyr  Asn Met Ile Asn Pro  Ile Asn His 
    2720                 2725                 2730             


Thr Arg  Thr Pro Ile Glu Cys  Met Lys Tyr Lys Val  Glu Pro Tyr 
    2735                 2740                 2745             


Val Met  Ala Ala Asp Val Tyr  Ala Val Asp Pro His  Ala Gly Arg 
    2750                 2755                 2760             


Gly Gly  Trp Thr Trp Tyr Thr  Gly Ala Ala Gly Trp  Met Tyr Arg 
    2765                 2770                 2775             


Val Ala  Val Glu His Ile Leu  Gly Leu Lys Lys Tyr  Gly Asp Lys 
    2780                 2785                 2790             


Phe Thr  Val Asp Pro Cys Val  Pro Arg Asn Trp Glu  Ser Phe Val 
    2795                 2800                 2805             


Ile Glu  Tyr Ala His Gly His  Ser Lys Tyr Val Ile  Lys Val Ile 
    2810                 2815                 2820             


Asn Pro  Asp Arg Val Asn Lys  Gly Val Arg Glu Ile  Tyr Leu Asp 
    2825                 2830                 2835             


Gly Glu  Pro Val Asp Lys Phe  Val Pro Leu Lys Asp  Glu Asn Lys 
    2840                 2845                 2850             


Val Phe  Arg Val Leu Val Val  Met Gly 
    2855                 2860         


<210>  206
<211>  1549
<212>  PRT
<213>  Thermoanaerobacter ethanolicus 

<400>  206

Met Leu Lys Arg Lys Asn Leu Gln Ser Leu Ile Met Ile Cys Trp Leu 
1               5                   10                  15      


Arg Lys Gln Gly Lys Gln Val Leu Leu Leu Leu Gln Lys Glu Lys Leu 
            20                  25                  30          


Ile Lys Lys His Trp Phe Lys Leu Gly Arg Met Leu Ala Ile Glu Asn 
        35                  40                  45              


Arg Tyr Lys Gly Leu Val Ser Trp Ser Gly Thr Met Phe Glu Tyr Phe 
    50                  55                  60                  


Met Pro Leu Leu Ile Met Lys Asn Tyr Gln Asn Thr Leu Leu Asp Glu 
65                  70                  75                  80  


Thr Tyr Ala Phe Ala Val Arg Val Gln Lys Asn Tyr Ala Lys Glu Leu 
                85                  90                  95      


Gly Ile Pro Trp Gly Ile Ser Glu Ser Gly Phe Tyr Ala Phe Asp Ile 
            100                 105                 110         


Asn Leu Asn Tyr Gln Tyr Lys Ala Phe Gly Val Pro Ser Leu Gly Leu 
        115                 120                 125             


Lys Arg Gly Leu Ser His Asp Lys Val Val Ala Pro Tyr Gly Ser Leu 
    130                 135                 140                 


Leu Ala Ile Gly Val Asp Val Glu Gly Val Leu Gln Asn Ile Arg Phe 
145                 150                 155                 160 


Leu Lys Lys Glu Gly Val Glu Gly Lys Tyr Gly Phe Tyr Glu Ala Ile 
                165                 170                 175     


Asp Tyr Thr Pro Glu Arg Phe Pro Phe Gly Lys Lys Ser Ala Ile Val 
            180                 185                 190         


Lys Ser Phe Met Ala His His Gln Gly Met Ala Phe Val Ala Leu Asp 
        195                 200                 205             


Asn Phe Ile Asn Asn Asn Ile Met Gln Lys Arg Phe His Lys Asp Pro 
    210                 215                 220                 


Ser Ile Lys Ala Ile Gln Ile Leu Leu Gln Glu Lys Met Pro Met Tyr 
225                 230                 235                 240 


Leu Asp Ile Thr Arg Glu Glu Arg Glu Glu Ala Arg Lys Ile Gln Lys 
                245                 250                 255     


Val Arg Lys Glu Asp Gly Asp Phe Val Arg Val Leu Gly Glu Ser Lys 
            260                 265                 270         


Thr Trp Leu Pro Glu Val His Ile Leu Ser Ser Gly Arg Tyr Phe Val 
        275                 280                 285             


Met Leu Thr Glu Lys Gly Thr Gly Tyr Ser Lys Asn Asn Lys Gly Ile 
    290                 295                 300                 


Phe Leu Thr Arg Trp Arg Lys Asp Leu Ala Gln Asp Phe Gly Thr Phe 
305                 310                 315                 320 


Ile Phe Val Gln Asn Ile Asn Ser Asn Thr Val Trp Ser Ala Thr Tyr 
                325                 330                 335     


Ala Pro Phe Tyr Glu Lys Gly Gln Asn Tyr Arg Val Val Phe Ser Ala 
            340                 345                 350         


Asp Lys Ala Glu Tyr Phe Lys Arg Val Gly Asn Ile Asp Thr His Leu 
        355                 360                 365             


Glu Ile Val Val Ser Pro Glu Asp Asp Val Glu Ile Arg Arg Leu Thr 
    370                 375                 380                 


Leu Lys Asn His Ser Lys His Pro Arg Ile Leu Glu Ile Thr Ser Phe 
385                 390                 395                 400 


Gly Glu Ile Ser Leu Ile Asp Leu Pro Thr Asp Val Ala His Pro Ala 
                405                 410                 415     


Phe Asn Lys Leu Phe Val Lys Thr Glu Phe Leu Lys Glu Glu Asp Ala 
            420                 425                 430         


Ile Leu Val Cys Arg Lys Pro Arg Glu Gln Gly Lys Asn Lys Leu Trp 
        435                 440                 445             


Ala Val His Lys Val Ala Val Leu Ser Gly Glu Ile Val Gly Asp Thr 
    450                 455                 460                 


Gln Phe Glu Thr Asp Arg Ala Lys Phe Ile Gly Arg Gly Arg Ser Leu 
465                 470                 475                 480 


Lys Asn Pro Ile Ala Leu Glu Ala Asp Gln Pro Leu Ser Asn Thr Glu 
                485                 490                 495     


Gly Ala Val Leu Asp Pro Ile Val Ser Leu Arg Lys Arg Val Lys Val 
            500                 505                 510         


Met Pro Gly Glu Val Ala Lys Val Val Tyr Ile Ser Ala Ile Thr Glu 
        515                 520                 525             


Thr Lys Glu Lys Ala Ile Lys Ile Ala Ala Lys Tyr Lys Glu Glu Asn 
    530                 535                 540                 


Val Val Glu Arg Asp Phe Glu Met Ser Trp Thr Arg Ser Arg Val Glu 
545                 550                 555                 560 


Leu Asp Tyr Leu Asn Leu Lys Pro Arg Glu Leu Gly Leu Leu Gln Arg 
                565                 570                 575     


Met Leu Ala His Ile Leu Phe Val Ser Pro Gln Arg Arg Tyr Arg Glu 
            580                 585                 590         


Glu Met Ile Leu Lys Asn Val Lys Gly Gln Ser Gly Leu Trp Ala Tyr 
        595                 600                 605             


Gly Ile Ser Gly Asp Leu Pro Ile Val Leu Val Glu Ile Glu Lys Met 
    610                 615                 620                 


Glu Glu Ile Glu Met Val Lys Trp Phe Leu Lys Ala Tyr Glu Tyr Trp 
625                 630                 635                 640 


Lys Met Lys Gly Ile Asn Ile Asp Leu Val Ile Leu Asn Lys Asp Lys 
                645                 650                 655     


Ser Gly Tyr Leu Gln Pro Leu His Asp Lys Ile Lys Glu Leu Ile Asn 
            660                 665                 670         


Thr Thr Phe Ser Tyr Asp Ile Phe Gly Lys Tyr Gly Gly Val Tyr Leu 
        675                 680                 685             


Leu Gln Gln Asn Asn Leu Lys Glu Glu Asp Val Tyr Leu Leu Asn Thr 
    690                 695                 700                 


Val Val Ala Leu Lys Phe Glu Gly Gly Asn Glu Ser Ile Tyr Asp Gln 
705                 710                 715                 720 


Ile Met Ile Lys Glu Thr Lys Asn Ala Pro Lys Leu Lys Asn Trp Val 
                725                 730                 735     


Lys Lys Val Gln Asn Phe Glu Glu Ile Lys Leu Glu Glu Leu Pro Leu 
            740                 745                 750         


Asp Tyr Tyr Asn Gly Phe Gly Gly Phe Ser Tyr Asp Gly Lys Glu Tyr 
        755                 760                 765             


Ile Ile Lys Trp Glu Gly Lys Ser Thr Pro Ala Pro Trp Ile Asn Val 
    770                 775                 780                 


Ile Ser Asn Pro Ser Phe Gly Phe Gln Val Ser Glu Thr Gly Ala Gly 
785                 790                 795                 800 


Tyr Thr Trp Ala Glu Asn Ser Arg Glu Tyr Lys Leu Thr Pro Trp Tyr 
                805                 810                 815     


Asn Asp Pro Val Leu Asp Pro His Gly Glu Val Ile Tyr Leu Thr Asp 
            820                 825                 830         


Glu Glu Thr Gly Asp Arg Trp Ser Ile Thr Pro Leu Pro Ala Gly Lys 
        835                 840                 845             


Ala Lys Val His Tyr Ile Lys His Gly Phe Gly Tyr Thr Ser Phe Glu 
    850                 855                 860                 


Thr Ile Cys Cys Gly Leu Ser Gln His Leu Lys Met Phe Val Ala Lys 
865                 870                 875                 880 


Glu Asp Ser Ile Lys Ile Asn Leu Val Thr Ile Lys Asn Leu Gly Asn 
                885                 890                 895     


Glu Asn Arg Lys Leu Thr Val Ser Tyr Tyr Ile Arg Pro Val Leu Gly 
            900                 905                 910         


Val Thr Asp Glu Ile Thr Phe Pro Tyr Leu Phe Thr Lys Tyr Asp Glu 
        915                 920                 925             


Lys Ile Gly Ala Leu Met Ile Lys Asn Val Tyr Asn Glu Asp Phe Ala 
    930                 935                 940                 


Asn Arg Leu Ala Phe Leu Ser Ala Ser Glu Lys Ile Asn Ser Phe Thr 
945                 950                 955                 960 


Gly Asp Arg Ala Glu Phe Ile Gly Val Ala Ser Ser Leu Thr Leu Pro 
                965                 970                 975     


Gln Ala Leu Glu Tyr Glu Thr Leu Ser Asn Ser Thr Gly Ile Ser Leu 
            980                 985                 990         


Asp Pro Cys Ala Ala Ile Gln Phe  His Val Glu Val Lys  Ala Lys Glu 
        995                 1000                 1005             


Glu Lys  Gln Phe Thr Ile Leu  Leu Gly His Gly Lys  Asn Glu Glu 
    1010                 1015                 1020             


Glu Val  Lys Arg Leu Ile Leu  Lys Tyr Thr Asn Val  Glu Asn Cys 
    1025                 1030                 1035             


Gln Asn  Glu Leu Gln Arg Val  Gln Glu Phe Trp Gln  Glu Leu Leu 
    1040                 1045                 1050             


Arg Arg  Ile Gln Ile Lys Thr  Pro Asp Lys Ser Met  Asp Leu Leu 
    1055                 1060                 1065             


Val Asn  Gly Trp Leu Pro Tyr  Gln Thr Ile Ala Cys  Arg Leu Trp 
    1070                 1075                 1080             


Ala Arg  Ser Ala Phe Tyr Gln  Ser Gly Gly Ala Tyr  Gly Phe Arg 
    1085                 1090                 1095             


Asp Gln  Leu Gln Asp Ala Met  Asn Met Val Tyr Leu  Glu Pro Glu 
    1100                 1105                 1110             


Phe Thr  Lys Asn Gln Ile Val  Asn Ala Cys Gln His  Gln Phe Val 
    1115                 1120                 1125             


Glu Gly  Asp Val Gln His Trp  Trp His Pro Val Leu  Asn Lys Gly 
    1130                 1135                 1140             


Ile Arg  Thr Lys Phe Ala Asp  Asp Leu Leu Trp Leu  Pro Tyr Val 
    1145                 1150                 1155             


Thr Ala  Asp Tyr Ile Glu Lys  Thr Gly Asp Trp Pro  Ile Leu Asp 
    1160                 1165                 1170             


Ile Glu  Val Asn Tyr Leu Glu  Asp Leu Arg Leu Lys  Glu Glu Glu 
    1175                 1180                 1185             


Glu Glu  Arg Tyr Ser Thr Pro  Arg Ile Ser Glu Thr  Lys Gly Thr 
    1190                 1195                 1200             


Val Tyr  Glu His Cys Ile Arg  Ala Ile Asp Tyr Ser  Leu Lys Phe 
    1205                 1210                 1215             


Gly Glu  His Gly Leu Pro Leu  Met Gly Ala Gly Asp  Trp Asn Asp 
    1220                 1225                 1230             


Gly Met  Asn Lys Val Gly Asn  Lys Gly Lys Gly Glu  Ser Val Trp 
    1235                 1240                 1245             


Leu Gly  Trp Phe Leu Tyr Thr  Ile Leu Gln Lys Phe  Ser Pro Ile 
    1250                 1255                 1260             


Cys Gln  Thr Lys Lys Asp Glu  Glu His Ala Lys Lys  Tyr Gln Glu 
    1265                 1270                 1275             


Ile Ala  Asn Lys Leu Ile Lys  Ala Ile Glu Glu Asn  Ala Trp Asp 
    1280                 1285                 1290             


Gly Ser  Trp Tyr Arg Arg Ala  Tyr Phe Asp Asp Gly  Thr Pro Leu 
    1295                 1300                 1305             


Gly Ser  Val Asp Asn Ser Glu  Cys Lys Ile Asp Ser  Ile Ser Gln 
    1310                 1315                 1320             


Ser Trp  Ser Val Ile Ser Lys  Ala Gly Lys Glu Val  Arg Val Lys 
    1325                 1330                 1335             


Glu Ala  Met Lys Ala Val Val  Asn Tyr Leu Val Asn  Glu Glu Glu 
    1340                 1345                 1350             


Gly Ile  Ile Lys Leu Leu Thr  Pro Pro Phe Asp Asn  Gly Asp Leu 
    1355                 1360                 1365             


Asn Pro  Gly Tyr Ile Lys Gly  Tyr Val Pro Gly Val  Arg Glu Asn 
    1370                 1375                 1380             


Gly Gly  Gln Tyr Thr His Ala  Ala Ala Trp Val Ile  Leu Ala Phe 
    1385                 1390                 1395             


Ala Glu  Leu Gly Glu Gly Asp  Arg Ala Trp Gln Leu  Tyr Asn Met 
    1400                 1405                 1410             


Ile Asn  Pro Ile Asn His Thr  Arg Thr Pro Ile Glu  Cys Met Lys 
    1415                 1420                 1425             


Tyr Lys  Val Glu Pro Tyr Val  Met Ala Ala Asp Val  Tyr Ala Val 
    1430                 1435                 1440             


Glu Pro  His Val Gly Arg Gly  Gly Trp Thr Trp Tyr  Thr Gly Ala 
    1445                 1450                 1455             


Ala Gly  Trp Met Tyr Arg Ile  Ala Ile Glu Asn Leu  Leu Gly Leu 
    1460                 1465                 1470             


Lys Lys  Tyr Gly Glu Lys Leu  Ile Ile Asp Pro Cys  Ile Pro Lys 
    1475                 1480                 1485             


Asn Trp  Asp Lys Tyr Val Ile  Glu Tyr Asn Tyr Lys  Asn Thr Lys 
    1490                 1495                 1500             


Tyr Leu  Ile Glu Val Arg Asn  Pro Glu Gly Val Asn  Lys Gly Val 
    1505                 1510                 1515             


Lys Glu  Val Tyr Ile Asp Gly  Glu Leu Val Thr Asp  Lys Thr Ile 
    1520                 1525                 1530             


Asp Leu  Thr Lys Glu Gly Asn  Gly His Gln Val Leu  Val Ile Met 
    1535                 1540                 1545             


Gly 
    


<210>  207
<211>  2823
<212>  PRT
<213>  Clostridium cellulolyticum 

<400>  207

Met Asn Asn Ile Leu Ile Leu Leu Ile Ile Thr Leu Ile Ala Ile Val 
1               5                   10                  15      


Ala Ala Leu Ile Gly Ile Val Leu Lys Asn Arg Pro Ser Tyr Glu Val 
            20                  25                  30          


Gln Ile Glu Asp Val Phe Leu Asn Ser Asp Asp Leu Met Arg His Ala 
        35                  40                  45              


Glu Gln Leu Ala Lys Thr Gln Thr Thr Asp Lys Arg Lys Leu Gly Ile 
    50                  55                  60                  


Arg Arg Val Arg Glu Arg Ile Glu Arg Asn Phe His Arg Val Leu Glu 
65                  70                  75                  80  


Met Tyr Gln Lys Phe Asn Leu Asp Ile Ser Ala Ser Phe Pro Val Pro 
                85                  90                  95      


Pro Ala Ala Glu Trp Leu Leu Asp Asn Phe Tyr Ile Ile Glu Glu Gln 
            100                 105                 110         


Lys Ser Met Leu Met Lys Glu Leu Ser Glu Val Lys Gln Ala Leu Pro 
        115                 120                 125             


Val Ile Ser Glu Gly Thr Tyr Ala Gly Tyr Pro Arg Val Phe Ala Ile 
    130                 135                 140                 


Ala Ala Asp Leu Val Ser His Cys Asp Gly Asn Val Asn Glu Lys Ile 
145                 150                 155                 160 


Ile Arg Asp Phe Ile Ala Ala Tyr Gln Lys His Thr Phe Leu Ser Ile 
                165                 170                 175     


Gln Glu Leu Trp Met Leu Ser Thr Met Leu Lys Ala Ala Leu Leu Glu 
            180                 185                 190         


Lys Leu Trp Ala Val Cys Asp Arg Met Phe Thr Asn Arg Gln Asp Trp 
        195                 200                 205             


Tyr Arg Ala Glu Gly Ile Val Asn Gly Ile Arg His Asn Asn Glu Asn 
    210                 215                 220                 


Cys Asp Asp Phe Arg Arg His Ile Asp Gln Leu Glu Glu Ile Thr Pro 
225                 230                 235                 240 


Ala Phe Ala Glu His Leu Ile Lys Lys Leu Arg Lys Asp Gly Ala Lys 
                245                 250                 255     


Thr Leu Trp Met Ile Glu Cys Leu Asp Ser Ile Leu Val Gln Lys Ser 
            260                 265                 270         


Thr Ser Thr Asp Ser Leu Ile Ser Glu Asp His Phe Asn Gln Ala Thr 
        275                 280                 285             


Leu Gln Val Ser Thr Gly Asn Val Ile Asn Ser Phe Arg Ala Leu Ser 
    290                 295                 300                 


Gly Phe Asp Asn Thr Val Leu Phe Glu Gln Leu Ser Glu Val Glu Arg 
305                 310                 315                 320 


Leu Leu Lys Leu Asp Pro Cys Gly Ile Tyr Pro Gln Met Asp Phe Asp 
                325                 330                 335     


Ser Arg Asn Tyr Tyr Arg Asp Ile Val Met Asn Leu Gly Ser Lys Tyr 
            340                 345                 350         


Asp Thr Thr Glu Ile Asn Ile Ala Arg Leu Cys Leu Asp Leu Ala Arg 
        355                 360                 365             


Glu Lys Tyr Asp Glu Asn Pro Ser Ile Thr Ala Glu Thr His Val Gly 
    370                 375                 380                 


Tyr Tyr Leu Ala Gly Lys Gly Arg Ser Ala Phe Ser Asn Lys Ile Gly 
385                 390                 395                 400 


Lys Tyr Lys Glu His Ser Phe Lys Asn Cys Glu Lys Trp Tyr Ile Thr 
                405                 410                 415     


Ala Ile Val Leu Phe Ser Val Val Ile Ala Leu Ile Pro Thr Val Asn 
            420                 425                 430         


Ser Phe Ser Arg Glu Asn Gly Arg Leu Ala Phe Ile Val Leu Leu Thr 
        435                 440                 445             


Gly Ile Leu Ser Ile Ile Pro Ala Ser Glu Ile Val Val Ser Val Leu 
    450                 455                 460                 


Asn Ser Cys Ile Ser Arg Ile Val Lys Pro Ala Arg Leu Pro Lys Leu 
465                 470                 475                 480 


Glu Leu Asn Asp Gly Ile Pro Glu Asp Trp Ala Thr Met Val Ile Ile 
                485                 490                 495     


Pro Thr Leu Ile Pro Asn Val Lys Arg Thr Val Glu Leu Ile Asp Asn 
            500                 505                 510         


Leu Glu Val Phe Tyr Leu Ala Asn Lys Gly Ser Asn Ile Tyr Phe Ser 
        515                 520                 525             


Leu Ala Gly Asp Phe Lys Asp Ser Asp Asp Glu Thr Leu Ser Asp Asp 
    530                 535                 540                 


Asn Glu Ile Val Glu Ala Ala Ile Lys Arg Val Gln Asp Leu Asn Arg 
545                 550                 555                 560 


Lys Tyr Cys Lys Asp Ala Lys Pro Ile Phe Tyr Phe Phe Cys Arg Lys 
                565                 570                 575     


Arg Arg Tyr Asn Glu Lys Gln Lys Lys Trp Leu Gly Trp Glu Arg Lys 
            580                 585                 590         


Arg Gly Ala Ile Leu Glu Phe Asn Arg Leu Leu Arg Arg Asp Arg Asn 
        595                 600                 605             


Thr Asp Tyr Val Phe Asn Ser Ala Thr Ile Asp Ser Leu Pro Asn Ile 
    610                 615                 620                 


Lys Tyr Val Ile Thr Leu Asp Ala Asp Thr Gln Leu Pro Leu Asp Thr 
625                 630                 635                 640 


Ala Lys Gln Met Val Gly Ala Met Ala His Pro Leu Asn Lys Ala Tyr 
                645                 650                 655     


Phe Asp Lys Glu Lys Gly Val Val Thr Lys Gly Tyr Gly Ile Met Gln 
            660                 665                 670         


Pro Arg Val Asp Val Asn Ile Glu Ser Ala Val Lys Ser Leu Phe Thr 
        675                 680                 685             


Arg Val Phe Ala Gly Gln Gly Gly Ile Asp Pro Tyr Thr Thr Thr Val 
    690                 695                 700                 


Ser Asp Val Tyr Gln Asp Ala Phe Gly Glu Gly Ile Phe Thr Gly Lys 
705                 710                 715                 720 


Gly Ile Tyr Asp Val Asp Ile Phe Thr Thr Ala Leu Asp Lys Thr Ile 
                725                 730                 735     


Pro Glu Asn Ser Val Leu Ser His Asp Leu Leu Glu Gly Ser Phe Leu 
            740                 745                 750         


Arg Thr Ala Leu Val Thr Asp Ile Glu Leu Ile Asp Gly Tyr Pro Ala 
        755                 760                 765             


Lys Tyr Asn Ser Phe Met Met Arg Leu His Arg Trp Thr Arg Gly Asp 
    770                 775                 780                 


Trp Gln Leu Leu Pro Trp Ile Leu Gly Lys Asn Pro Leu Ser Met Leu 
785                 790                 795                 800 


Ser Arg Trp Lys Met Ile Asp Asn Leu Arg Arg Ser Leu Val Gln Pro 
                805                 810                 815     


Val Leu Ala Leu Ile Ala Leu Leu Ala Val Trp Leu Phe Arg Asn Ser 
            820                 825                 830         


Tyr Arg Glu Trp Leu Ile Leu Ala Leu Ile Ser Leu Cys Ser Pro Val 
        835                 840                 845             


Leu Asn Tyr Phe Val Gln Leu Leu Ile Ala Gly Asn Tyr Lys Ile Tyr 
    850                 855                 860                 


Ile Ala Lys Arg Arg Thr Thr Ile Ile Thr Gly Phe Lys Ala Ile Leu 
865                 870                 875                 880 


Leu Gln Leu Gly Leu Leu Leu Thr Phe Leu Pro Tyr Gln Ala Glu Leu 
                885                 890                 895     


Met Val Asn Ala Val Ser Lys Ser Ile Phe Arg Val Tyr Ile Thr Lys 
            900                 905                 910         


Lys Asn Leu Leu Glu Trp Val Thr Ala Ala Asp Met Glu Met Ser Leu 
        915                 920                 925             


Lys Asn Gly Val Gly Ser Tyr Tyr Arg Arg Met Trp Phe Cys Pro Val 
    930                 935                 940                 


Tyr Gly Ala Val Ile Leu Leu Leu Ser Ile Leu Tyr Arg Gln Ser Phe 
945                 950                 955                 960 


Val Pro Val Ala Ser Leu Leu Phe Val Leu Trp Val Leu Ser Pro Trp 
                965                 970                 975     


Ile Ala Tyr Tyr Ile Ser Val Pro Thr Glu Lys Asn Arg Val Val Leu 
            980                 985                 990         


Asp Ser Ala Gly Val Glu Glu Val  Arg Leu Leu Ala Arg  Arg Thr Trp 
        995                 1000                 1005             


Cys Tyr  Phe Asp Glu Phe Ala  Gly Pro Glu Glu Asn  Tyr Leu Pro 
    1010                 1015                 1020             


Ala Asp  Asn Tyr Gln Glu Glu  Pro Tyr Lys Gly Ala  Ala His Arg 
    1025                 1030                 1035             


Thr Ser  Pro Thr Asn Ile Gly  Leu Leu Leu Val Ser  Asn Leu Ala 
    1040                 1045                 1050             


Ala Arg  Asp Met Gly Tyr Ile  Asn Thr Leu Asp Phe  Leu Ala Arg 
    1055                 1060                 1065             


Ile Glu  Asn Thr Ile Ser Thr  Val Glu Lys Met Asp  Lys Trp Asn 
    1070                 1075                 1080             


Gly His  Leu Tyr Asn Trp Tyr  Asn Thr Val Thr Leu  Glu Val Leu 
    1085                 1090                 1095             


Arg Pro  Lys Phe Ile Ser Thr  Val Asp Ser Gly Asn  Phe Ile Gly 
    1100                 1105                 1110             


Tyr Leu  Met Val Leu His Glu  Gly Leu Ser Gly Leu  Met Glu Ser 
    1115                 1120                 1125             


Pro Ile  Tyr Asp Phe Ser Thr  Ile Glu Gly Leu Phe  Asp Leu Leu 
    1130                 1135                 1140             


Glu Ile  Cys Asn Ser Glu Ile  Glu Gly Ser Lys Ala  Tyr Phe Asp 
    1145                 1150                 1155             


Thr Glu  Leu Leu Lys Lys Leu  Thr Asp Ser Asp Asn  Ile Glu Glu 
    1160                 1165                 1170             


Ser Phe  Lys Asn Leu Leu Pro  Ala Val Leu Lys Leu  Val Asp Glu 
    1175                 1180                 1185             


Leu Asp  Lys Ser Lys Arg Thr  Gly Tyr Trp Phe Lys  Lys Leu Asp 
    1190                 1195                 1200             


Ser Asn  Ile Asn Thr Phe Asn  Ser Glu Tyr Thr Lys  Tyr Arg Gly 
    1205                 1210                 1215             


Ile Leu  Phe Ala Pro Leu Lys  Asn Val Pro Gln Glu  Leu Lys Arg 
    1220                 1225                 1230             


Ile Gln  Gln Leu Gln Thr Lys  Val Gln Gln Leu Ile  Asp Ala Met 
    1235                 1240                 1245             


Glu Phe  Lys Tyr Leu Phe Asp  Pro Ala Arg Asn Leu  Phe Thr Ile 
    1250                 1255                 1260             


Gly Phe  Asp Val Glu Asp Gly  His Ala Ser Lys Ser  Tyr Tyr Asp 
    1265                 1270                 1275             


Leu Phe  Ala Ser Glu Ala Arg  Gln Thr Ser Leu Val  Ala Ile Ala 
    1280                 1285                 1290             


Arg Gly  Glu Ala Gly Arg Gln  His Trp Phe Lys Leu  Gly Arg Lys 
    1295                 1300                 1305             


Leu Val  Arg Val Asn Gly Met  Lys Gly Leu Ala Ser  Trp Thr Gly 
    1310                 1315                 1320             


Thr Met  Phe Glu Tyr Leu Met  Pro Arg Leu Leu Ile  Lys Ser Tyr 
    1325                 1330                 1335             


Ser Asn  Thr Leu Ile Asp Lys  Thr Tyr Glu Phe Val  Val Lys Thr 
    1340                 1345                 1350             


Gln Ile  Lys Tyr Gly Leu Ala  Asn Lys Ala Pro Trp  Gly Ile Ser 
    1355                 1360                 1365             


Glu Ser  Cys Tyr Tyr Ala Phe  Asp Ile Gly Leu Asn  Tyr Gln Tyr 
    1370                 1375                 1380             


Arg Ala  Phe Gly Val Pro His  Leu Gly Leu Lys Arg  Gly Leu Ala 
    1385                 1390                 1395             


Asn Asp  Phe Val Ala Ala Pro  Tyr Ala Thr Val Met  Ala Leu Asp 
    1400                 1405                 1410             


Ile Ala  Pro Gln Glu Cys Leu  Glu Asn Ile His Arg  Phe Lys Glu 
    1415                 1420                 1425             


Ile Gly  Ala Phe Gly Asn Phe  Gly Leu Tyr Glu Ala  Val Asp Phe 
    1430                 1435                 1440             


Thr Asn  Ser Arg Ile Ser Lys  Asp Gln Ser Tyr Ala  Val Val Lys 
    1445                 1450                 1455             


Cys Tyr  Met Val His His Gln  Gly Met Ser Met Leu  Ala Leu Val 
    1460                 1465                 1470             


Asn Phe  Phe Lys Asn Asn Ile  Met Gln Glu Arg Phe  His Gly Asn 
    1475                 1480                 1485             


Pro Leu  Ile Lys Ala Val Asp  Ser Leu Leu Gln Glu  Lys Phe Pro 
    1490                 1495                 1500             


Ala Ala  Ala Met Ile Thr Lys  Glu Tyr Arg Glu Gln  Pro Val Gly 
    1505                 1510                 1515             


Gly Met  Arg Lys Asn Val Asn  His Lys Asp Thr Val  Ile Arg Glu 
    1520                 1525                 1530             


Tyr Asn  Lys Leu Ser Pro Tyr  Pro Gly Ile His Leu  Leu Ser Asn 
    1535                 1540                 1545             


Gly Asn  Tyr Tyr Leu Met Ile  Thr Asp Lys Gly Ser  Gly Tyr Ala 
    1550                 1555                 1560             


Lys Tyr  His Ser Met Ala Val  Tyr Arg Trp Ile Asn  Asp Tyr Met 
    1565                 1570                 1575             


Gln Ser  Ser Gly Ala Phe Ile  Tyr Ile Arg Asn Leu  Asn Ser Asn 
    1580                 1585                 1590             


Glu Phe  Trp Ser Thr Thr Tyr  Asn Pro Thr Asn Thr  Lys Pro Glu 
    1595                 1600                 1605             


Ala Tyr  Lys Val Ile Phe Ala  Pro His Lys Ala Glu  Phe Val Arg 
    1610                 1615                 1620             


Arg Glu  Gly Asn Ile Glu Thr  Asn Thr Glu Val Ile  Ile Ser Ser 
    1625                 1630                 1635             


Glu Asp  Asn Thr Glu Val Arg  Arg Val Ser Ile His  Asn His Ser 
    1640                 1645                 1650             


Ser Ser  Lys Arg Ile Ile Glu  Leu Thr Ser Tyr Met  Glu Val Val 
    1655                 1660                 1665             


Leu Thr  Gln His Glu Ala Asp  Ser Ala His Pro Ala  Phe Ser Lys 
    1670                 1675                 1680             


Leu Phe  Val Lys Thr Glu Tyr  Val Asp Glu Tyr Asn  Gly Leu Leu 
    1685                 1690                 1695             


Ala Met  Arg Arg Lys Arg Asp  Asp Ile Lys Gln Thr  Ser Trp Gly 
    1700                 1705                 1710             


Tyr His  Ile Ala Ser Thr Asn  Gly Lys Ala Tyr Gly  His Val Glu 
    1715                 1720                 1725             


Tyr Glu  Thr Asp Arg Ser Leu  Phe Ile Gly Arg Asn  Arg Asn Leu 
    1730                 1735                 1740             


Ala Tyr  Pro Arg Ala Met Glu  Pro Asp Arg Pro Leu  Ser Asn Ser 
    1745                 1750                 1755             


Val Gly  Ser Val Ile Asp Pro  Val Phe Ser Leu Arg  Ile Arg Val 
    1760                 1765                 1770             


Thr Val  Glu Pro Gly Glu Ser  Thr Ile Val Asn Phe  Cys Met Gly 
    1775                 1780                 1785             


Ala Cys  Asp Asn Arg Lys Thr  Ala Val Glu Met Leu  Ala Lys Tyr 
    1790                 1795                 1800             


Ser Asp  Pro Ala Ala Ala Asp  Arg Val Ile Asp Met  Ala Trp Thr 
    1805                 1810                 1815             


Arg Ser  Ile Val Glu Glu Gly  Phe Ile Asn Val Asp  Ala Asp Glu 
    1820                 1825                 1830             


Glu Lys  Ala Tyr Ile Lys Leu  Leu Pro Arg Leu Ile  Phe Gly Ile 
    1835                 1840                 1845             


Asp Arg  Arg Glu Gln Ala Glu  Tyr Ile Leu Ser Asn  Ser Leu Ser 
    1850                 1855                 1860             


Gln Ser  Asp Leu Trp Pro Phe  Gly Ile Ser Gly Asp  Leu Pro Ile 
    1865                 1870                 1875             


Val Leu  Val Thr Val Lys Ser  Arg Asp Ser Phe Glu  Glu Ile Asp 
    1880                 1885                 1890             


Trp Ala  Leu Lys Leu His Asp  Phe Tyr Arg Ile Lys  Gly Val Val 
    1895                 1900                 1905             


Phe Asp  Leu Val Ile Leu Leu  Thr Asp Glu Glu Ser  Tyr Ile Gln 
    1910                 1915                 1920             


Pro Ile  Phe Glu Met Ile Arg  Asp Met Ala Val Ser  Gly Arg Ser 
    1925                 1930                 1935             


Tyr Glu  Leu Leu Asp Lys Arg  Gly Gly Ile Phe Ile  Arg Asn Ser 
    1940                 1945                 1950             


Arg Gln  Met Lys Val Glu Gln  Lys Asn Leu Leu Phe  Ala Ser Ala 
    1955                 1960                 1965             


Lys Ile  Ile Leu Asp Ala Asp  Glu Gly Ile Pro Ser  Leu Met Glu 
    1970                 1975                 1980             


Ile Ile  Glu Gly Ile Glu Lys  Ser Met Asp Val Glu  Ile His Thr 
    1985                 1990                 1995             


Pro Leu  Glu Pro Ser Glu Glu  Ser Ser Ala Pro Ser  Leu Val Ser 
    2000                 2005                 2010             


Glu Ser  Glu Tyr Ser Gly Lys  Asp Val Val Thr Ala  Ala Glu Leu 
    2015                 2020                 2025             


Leu Phe  Phe Asn Gly Phe Gly  Gly Phe Thr Lys Asp  Gly Arg Glu 
    2030                 2035                 2040             


Tyr Val  Ile Gln Leu Ser Asp  Gly Met Ser Thr Pro  Ala Pro Trp 
    2045                 2050                 2055             


Val Asn  Val Ile Ala Asn Glu  Arg Phe Gly Phe Ile  Cys Thr Glu 
    2060                 2065                 2070             


Ser Gly  Gly Gly Tyr Ile Trp  His Leu Asn Ser Ser  Gln Asn Lys 
    2075                 2080                 2085             


Leu Thr  Ser Trp Ile Asn Asp  Pro Ile Thr Asp Thr  Pro Ser Glu 
    2090                 2095                 2100             


Ile Ile  Tyr Ile Cys Asn Thr  Gln Asn Gly Lys Val  Trp Ser Cys 
    2105                 2110                 2115             


Thr Pro  Leu Pro Val Arg Glu  Ala Glu Pro Tyr Thr  Ile Arg His 
    2120                 2125                 2130             


Gly Phe  Gly Tyr Thr Cys Phe  Gly His Lys Ser Asn  Gly Ile Asn 
    2135                 2140                 2145             


Gln Thr  Leu Thr Gln Phe Ala  Ala Thr Glu Ala Ala  Val Lys Phe 
    2150                 2155                 2160             


Ser Ile  Leu Lys Leu Glu Asn  Ile Thr Thr Ser Glu  Met Leu Leu 
    2165                 2170                 2175             


Glu Thr  Ala Tyr Tyr Phe Arg  Pro Leu Leu Gly Thr  Glu Phe Pro 
    2180                 2185                 2190             


Gln Thr  Ser Pro Tyr Ile Val  Thr Glu Phe Asp Glu  Thr Ser Asn 
    2195                 2200                 2205             


Ala Ile  Ile Ile Asp Asn Val  Tyr Ser Ala Asp Phe  Arg Gly Leu 
    2210                 2215                 2220             


Arg Ala  Phe Leu Ala Cys Ser  Glu Ser Gly Val Ser  Tyr Thr Gly 
    2225                 2230                 2235             


Ser Arg  Leu Lys Phe Phe Gly  Pro Gly Met Glu Ile  Ser Asn Pro 
    2240                 2245                 2250             


Ala Gly  Met Arg Glu Glu Leu  Asp Ser Ile Thr Gly  Ala Gly Ile 
    2255                 2260                 2265             


Asp Ala  Cys Ala Ala Leu Lys  Ala Ser Ile Arg Leu  Arg Pro Gly 
    2270                 2275                 2280             


Glu Thr  Lys Glu Ile Leu Phe  Ile Val Gly Gln Glu  Lys Ser Glu 
    2285                 2290                 2295             


Lys Val  Thr Glu Val Ile Ser  Ala Phe Arg Asn Ile  Glu Asn Ala 
    2300                 2305                 2310             


Lys Asn  Glu Met Glu Lys Val  Lys Asp Ser Trp Asn  Arg Arg Leu 
    2315                 2320                 2325             


Gly Gln  Ile Gln Val Lys Thr  Pro Asp Asp Ser Ile  Asn Leu Met 
    2330                 2335                 2340             


Leu Asn  Gly Trp Leu Gln Tyr  Gln Val Leu Ser Cys  Arg Ile Trp 
    2345                 2350                 2355             


Ala Arg  Thr Gly Phe Tyr Gln  Ala Gly Gly Ala Phe  Gly Phe Arg 
    2360                 2365                 2370             


Asp Gln  Leu Gln Asp Val Met  Ala Val Val Tyr Ser  Leu Pro Glu 
    2375                 2380                 2385             


Leu Thr  Lys Asn Gln Ile Leu  Leu His Cys Arg His  Gln Phe Val 
    2390                 2395                 2400             


Glu Gly  Asp Val Gln His Trp  Trp His Asn Gln Lys  Met Asn Gly 
    2405                 2410                 2415             


Ile Arg  Thr Arg Tyr Ser Asp  Asp Leu Leu Trp Leu  Pro Tyr Val 
    2420                 2425                 2430             


Thr Cys  Asp Tyr Ile Asn Ala  Thr Gly Asp Phe Glu  Ile Leu Asn 
    2435                 2440                 2445             


Leu Glu  Glu Arg Tyr Ile Thr  Ser Pro Thr Leu Asn  Glu Asn Glu 
    2450                 2455                 2460             


His Glu  Arg Tyr Glu Val Pro  Ser Asp Ser Gly Leu  Lys Gly Thr 
    2465                 2470                 2475             


Val Tyr  Asp His Cys Ile Arg  Ala Ile Asp Lys Gly  Leu Lys Phe 
    2480                 2485                 2490             


Gly Ile  His Gly Ile Pro Leu  Met Gly Gly Gly Asp  Trp Asn Asp 
    2495                 2500                 2505             


Gly Met  Asn Leu Val Gly Val  Gln Gly Lys Gly Glu  Ser Ile Trp 
    2510                 2515                 2520             


Leu Gly  Trp Phe Met Tyr Cys  Val Leu Leu Arg Met  Ile Pro Ile 
    2525                 2530                 2535             


Cys Asn  Lys Met Gly Asp Val  Glu Arg Ala Glu Asn  Tyr Lys Thr 
    2540                 2545                 2550             


Lys Ala  Asp Ala Ile Ile Glu  Ala Ile Glu Arg Glu  Ala Trp Asp 
    2555                 2560                 2565             


Gly Ser  Trp Tyr Arg Arg Ala  Tyr Phe Asp Asp Gly  Thr Pro Leu 
    2570                 2575                 2580             


Gly Ser  Met Glu Asn Asp Glu  Cys Lys Ile Asp Ser  Leu Ser Gln 
    2585                 2590                 2595             


Ser Trp  Ala Ala Ile Thr Gly  Ala Ala Lys Asn Ser  Arg Val Glu 
    2600                 2605                 2610             


Glu Ala  Met Ser Ala Val Glu  Lys Tyr Leu Val Asp  Arg Arg Asn 
    2615                 2620                 2625             


Gly Leu  Ile Lys Leu Leu Thr  Pro Pro Phe Tyr Asp  Ser Glu Leu 
    2630                 2635                 2640             


Asn Pro  Gly Tyr Ile Lys Gly  Tyr Leu Pro Gly Val  Arg Glu Asn 
    2645                 2650                 2655             


Gly Gly  Gln Tyr Thr His Ala  Ala Thr Trp Val Val  Tyr Ala Phe 
    2660                 2665                 2670             


Cys Lys  Leu Gly Asp Gly Glu  Arg Ala Trp Glu Leu  Phe Ser Met 
    2675                 2680                 2685             


Ile Asn  Pro Val Asn His Ala  Arg Thr Lys Ser Glu  Ser Met Thr 
    2690                 2695                 2700             


Tyr Lys  Val Glu Pro Tyr Val  Met Ala Ala Asp Val  Tyr Ala Val 
    2705                 2710                 2715             


Tyr Pro  Asn Glu Gly Arg Gly  Gly Trp Thr Trp Tyr  Thr Gly Ala 
    2720                 2725                 2730             


Ala Gly  Trp Met Tyr Arg Ile  Gly Ile Asp His Leu  Leu Gly Ile 
    2735                 2740                 2745             


Lys Lys  Gln Gly Asn Ser Ile  Leu Leu Asn Pro Cys  Ile Pro Gln 
    2750                 2755                 2760             


Asn Met  Asn Glu Tyr Ser Val  Arg Tyr Val Tyr Gly  Ser Ser Val 
    2765                 2770                 2775             


Tyr Asn  Ile Thr Val Lys Asn  Pro Gly His Lys Asn  Thr Thr Val 
    2780                 2785                 2790             


Glu Arg  Ile Thr Ile Asp Gly  Lys Thr Thr Glu Thr  Asn Arg Ile 
    2795                 2800                 2805             


Glu Leu  Ile Asp Asp Gly Arg  Thr His Glu Val Glu  Ala Val Met 
    2810                 2815                 2820             


<210>  208
<211>  8151
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 201

<400>  208
atggcgttcg acacagagat cgagaggcgc gcgcatgcat tggcgctgac gcaagacatc     60

agttcgacgc gcggcggggg atccgacctg tggcccatct tgcgccgaaa ggcggcccgg    120

gtgcggaatc tcgccaccag gctcgagcga gagcctgcgg cgtgttctga gcccgcgcac    180

gagtggctga tcgatcacgc cgcctatctc gaactccagg cgatgttggc ggagcgcctg    240

tggccgaacg ccgtggtgcg gaaactgccg aggatggccg agaccgggga gccccgcgtg    300

gtgaccctcg ccgcggccta cctcgatgcg acgcgcggac acgtcgaagc cgagacgctc    360

atccggtttg tcgaggcgta ccaggacgtc caggttctga cgacgcacga gtgtcaccag    420

ctggccaacg gcctgcgcgt cgcgatcctc acgcggctcg ccgaagcgag cgatgagata    480

cagcatcggt acgagacgtg tcgcgcggtc ggccgcttgc tcgacgagat cgagcgggga    540

gacgggccag tggccgtgcg ccgcgccatc gaccgctttt ctaagggacg tgggcttggc    600

gccgtggagg tggtgcatct cgtgcatcac ctgtccgagt gggagccgga cagccaggag    660

ctgcgcgagt ggctggcggc gcacgtcgcc aactcttccg agagcatcga gcggctgacg    720

acgtacgagg ccgagtggca cgccgaaatc caggtgctca tcggcaatct ggtgcagagc    780

ctgcacgcgc tggagcgcat gtcctggcag cccatcgcct cgcgcatctc ccgggtggag    840

tcctgcctgc ggcaagaacc gacgggcgac tacctgcggc tcgatccgac gagccagaac    900

gtgctcacgc agcaggtcag ctggctcagc gaggccttcc gcctgcccga ggcgatgatc    960

gccgagaccg ccgtctcgtt ggcgcgagag gcctgggaga aggccggatc gcccaccgcc   1020

tcgagcgacc tgccgcggga ggcgtttgtc gcgtactatc tgtgcgatcc cgacgggatg   1080

cacgcgcttc accgatcgct caaggagcgc gcgaagccga gatcagttcc gcagattgca   1140

cttcgccgcc gtccccttcg ttcgtacctc cttggtgtgg cgtttctgtt cgcggccatc   1200

ctgtgggcgg tgctcggggg gttcacgggc ggatttcgcg cgccccttgg ggcgacgctg   1260

gcgcttgccg tcctgctcgc gcttcccgtc agcgaatggg tcatttcgct cgtgcacgag   1320

gggatacgcc gcgccgttcg gcctgtgcct ctcctgcgcc tcgacttcag cgaggggatt   1380

ccggaggacg cgcgcaccct gatcgtgctc cccgtcattt gggcgagcga ggccgacgtc   1440

gacgaggcgt ttgacaagat cgagcttcac cacctgacga accgcggggc ccatctctac   1500

ttcgcggtgc tctcggacct ccgggacgcc gacgcgccgc acctgccgga ggacgagcct   1560

ttgctcgccc gggcgcgcgc gcgcctggag gcgctgcggc acaagtacgg agccgctcgc   1620

ttcttttggt tccaccgcga tcgcgtcctc aaccgcgcgg acggcgtcta catgggctgg   1680

gagcgaaagc gaggcaagct ggtggagttt gtcgagctgc ttcgcggcaa gcgcgacacg   1740

accttccgcg tgaaagacgg cgatctcgcc gtgctgccga cgattcgcta cgtgttcacc   1800

gcggatctcg acaccgaact gcccattggc accgtgcagc gccttgtcgg caccatgcac   1860

ctgccataca accggccgcg gctcaacgcc cgtggcacgc gggtggacca gggctacggc   1920

gtgctccagc cggccgtcgc cgtcagcccg cgctcgaccc aggcctcccg attcgcgcgc   1980

ctctggtcgg gcgagacggg cgtggatccg tacgcgttcg ccatctccaa cccttatcag   2040

gattggttcg ggcgcggcct gttcgtcggc aaggggctta tccacgtcga cgcgtttcac   2100

accgtgctgt gcgatcgcat cccggacaac cgggtcttaa gccacgacat cctcgaaggc   2160

gggtttttgc gcgccggcct cgtggcggac gtggaggtgg tcgagagcca gccggcgacg   2220

ctgcgcgcct acatgcgccg cgcccatcgg tgggtgcgtg gagactggca gctgacgtat   2280

tggttgcgcc gggtgtgtcg cgatcggcgc ggggagacgc agcctgtgga tttgtgcggc   2340

ttcacgcgct ggaacatcgt cgatcacgtc cggcacagcc tggtcaaccc cgcgctcgtc   2400

ctgctcatgg gctccggcat gtcagggctt ttgcccggcc cagcgtacgc atacggcgcc   2460

gtgctcctta tcaccgtgtt tttgcccttt ttgcgccagc ttgagtccat ccggcccggc   2520

gaatgggact ggaggagcgc cgcgacggcg cttggccaga gcctggtcat gctcgtgacg   2580

ctgccgttca tggcggtggt cgaggcggac gccagcctgc gcgctctgta tcggatgctc   2640

gtcagccgac ggcggctgct cgagtggatc ccctcctctc acgcggaccg gtcggacgga   2700

tcgcccgcgc ctcttctcta cgagccggcg ggttacgcgg tcgcgctggc gtgttcggtg   2760

cctgggctct tcggcacgtg ggaacaggcg ctctcgagca ccctcgcgct cgcggtgtgg   2820

ctgccggcgc acgccgtggc acgctttctg gcgaagcccg cgggagaagc gcgcgtcgcg   2880

gcgcccgatc ctgcactctc cgcgcacctg cgcgaggtgg ccacggcgat gtggcggttt   2940

tacgagcggt acgtcggcga agaagatcat cacctgccgc cggacaacgt gcagtttgag   3000

cccgtggagc ggatcgcgca ccgcacgtcg ccgaccaaca tcgggctcta tctcttgtgc   3060

gtcgccgcgg cggcggatct cgagatcatc ccgaaggaag gcgccatcgc ccgcctcgag   3120

cgaaccctgg cgacgctcac gtccctggat cgatggcatg ggcacctgtt caactggtac   3180

gacacgcgca cgctcaggcc cctcgcgccg aggtacgtct cgaccgtgga ctctggcaat   3240

ctggtctgcg cgatgctcgc cttggggcag gccctgcgcg aatgggcggc atccgacgcg   3300

gacatcgccc ctcgcgcgcg ccgccttgcg gacgcgatgg agggcttcgc gcgggagatc   3360

gattttcgtc ctttgtatcg cccggatctc aggctttttt cgttgggctt tcacgcggat   3420

cgaaacgagc tcgagaacat cgtctacgat ctcctcgcct ccgaggcgcg ccaggcaagc   3480

ttcatcgcca ttgcgagcgg ccaggtgccc gcgtcgcact ggttcgcgct gtcccgcacc   3540

atgacgcgcg cgggccggta ccagccgctt ttgtcctggt ccgggacgat gttcgaatat   3600

ctcatgcccg cgctcctgat gcgccatctc cctcacacgc tgtgggagga gacctaccgt   3660

ggtgtcgtgt ggagacagat cgcctacgcg cgagagcgcg gcgtcccgtt cggcatctcg   3720

gagagcggct tctacgcgtt cgatcgcgac ctcaactacc aataccgggc gtttggcgtg   3780

ccggggctcg ggctggaccg cggcctggag caacacctcg tggtggcgcc gtatgcgacc   3840

atgctggcgc ttcccttcgc ccctgaacag gtggccgagg cgctccggca attgcgggaa   3900

cttggagcgc tgggaccgta cggctattac gaggccgtcg acttcacggc gagccggctt   3960

ccgccgggag accggtacaa ggtggtgcag agcttcatgg cgcaccacca gggcatggcg   4020

ttcatcgcca tcgccaacta cctgaatcgc aacctttggg tggagcggtt ccatcgcctg   4080

ccgctggtgc gcgcggccga gtacatgctg tacgagcgta tgccgaagcg gcccgcgctg   4140

ctcctcaagc cggttcacgc cgcgcacgcg cccaacttcg atcgcccggt ctacgcgcgc   4200

cggcgaagtg gagacgatgt ggcctggaac gcggtctcca acggcagcct gacgagtttc   4260

gctgacgcgc gcggcgaggg cgggatcgcc tggcgcggca tcgcggtgac gcgctaccgg   4320

ccggatcggc acctgcccta tcgcggaccg gtcatgtacg tgcgagatgt cgatcgcggc   4380

ggcgtctttc gcaccaccct gcacggtggc ggcggacacg tagaggcgga gtttcgcccg   4440

gacaagtcga gttggaagcg cgtggtggac gggatcgaga gcgagtggtc ggtcctcgtg   4500

gccccggatc gagacgtgga gattcggacg ttggtccttc agaacctcgg ggaggacgtt   4560

cgccggctcg aggtgaccta tttcgccgaa ctcgcgcttg cgaagccggc tgcggacatc   4620

gcgcatccgt cgtttcagcg cctgttcgtc gagacgggat gggacgatgc gcgccaggtg   4680

ctgtgggccc agcgcaggcc cgagtcggac gatcagccag acgtgtacgc ggcgtttcac   4740

ctcgtcgcag acgaggaagc gccagcgccg gtggagtggg actcccatcg ggcgcggttc   4800

gtcggccgcg gcggcagcct cgcggcgccg cgggggctct ggcgccgtct gcgtggcgaa   4860

ggggtggccg atccggccgc gattctccgc acggccgtga ccctcgcacc cggggaaaag   4920

cgcgcgctct atgtcatcac cgcgctcggc gaggcgcggg acgaggtcgt ggagacggcg   4980

tttgaaatgc gccagccttc ggcccgatcg cgcgcggcgc agctcgcgtg gatgcgcgcg   5040

cagatcgatc tccgccagct gcacctttcg ccggacgatg tcgaggacgc catggaactt   5100

ctgtcgcggt tcttgtcccg gcacgcgttt tcgcccgagc ggcgggcggc cattctgcag   5160

aacgagcttg gccaatccgg gctctgggcg cacgggattt ccggcgatcg acccatcgtc   5220

gccgtccggc tcgcctccgc ggcggaggtc ccgtttgtcg cgaagctcgc gcggctcacg   5280

cagtatcttg cgcacatggg cttcgcgagc gatctcgtcg tgatcgacga gacgatatcc   5340

agctatcgag acgagatgcg ggatcggatc cgggcggaga tggcgcgccg cggcgtgcac   5400

gacgcggcga ccctcgccgt ggtgaaggcg gatcagcttt cgagcgccga gcgggcgctc   5460

atggaatcgg tggctgtcgc gacgttgcgg gccggtgggc cgagcgtcgg cgcgcagctc   5520

acgggcggac gggtgcggcg cgaggaatcg gcgagactcg cgtcggaccg cctggagccg   5580

gagccgaaac gcgcgccgcg cgatgcgggg caggtggagg gagagtttgc gaacggctat   5640

ggcgcgttcg tcgacgacgg tcgcgcgtac cgcatgcgtg tgacgcgcgc caagcggccc   5700

ccgcggccct ggtcgaacgt gcttgccaat cccaacttcg gcgcgctcgt gactgagctc   5760

ggcaccggct acacctggtg gcgcaacagc cgcgagttca agctcacgcc ctggcacaac   5820

gatgccgcct tcgacccgcc cggcgaggcc gtgtacatcg ccgatctcga ccgcggaatc   5880

atcgcgagcg ccaccccttc gcccgccggc gatgaacgga cgtacgacgt gacgcatcgg   5940

cccggcgtca ccacgtttga aagcgacgtg gagggcgtcc gcgtcacgct tcatgtgttc   6000

gtcgattctg ccgagcccgc gaagtggatg cgggtgcggc ttcgcaacca aagcggggag   6060

gagcgcagaa tccgcgtggc cccgtatgcc gaatgggtgc tcggcgtgga tccgttctcg   6120

aacacgcccc tcgtcgtggt gcggaagatg ggcgaagcgg atgccatcgc tgcggaaaac   6180

cggtatcagg aggcgtttcg cggcgccttg ggctttctgg ccgtgggcgg cgccggacgg   6240

acaacggggt ggttgggaga caagacgcgc ttcctcggcg acggatcgta tgctcggccc   6300

gacgcgctgc tcgaggacgc gtggcgcggg ggagacggcc ccacgccgac gccctgcgcc   6360

gtccttgcgc gcgatctcga ccttgggccg catgaggagg ccgaggtggt catcctcctt   6420

ggcgcggcgc ctgacgaaca cgaggccgcg aggctcgccc ggctcgccga cccggccgcg   6480

gcggatcgcg cgcttcgcga ggtcactaga ttctgggatg atcttcttgg gcgtgtccaa   6540

atccgcacac cggatcgcgc cttcgacatc ctgatgaacg gctggctcgt gtaccaggcc   6600

ctcgcctgcc gcctctgggc ccgcacggcc ttttaccagg ccggcggcgc gttcggcttt   6660

cgcgatcagc tgcaggacgc cctcgcgctg attcacgctc gacccgacat cctgcgcgat   6720

cagatcctgc gggcggcgcg ccatcagtac gtcgagggcg acgtgcagca ctggtggcat   6780

gaggagttgg gcaaaggcat ccgcacgcgc ttttcggacg atttgctttg gcttccgtac   6840

gcggtctcgc gttacctcga ggcgacgggc gatgccgcgc tcctcgatga acgcgcgccg   6900

tatctcgtga gcgccccgct tggcgacggc gaactcgagc gatacgagga cagcgtctgg   6960

agccaggagg aaggcaccct cgcggaacac gtcgcgcggg ctgtggagcg cgcgcttcac   7020

ttcggcgatc acggcctccc gctcatcggc atcggcgact ggaacgacgg cctgagccga   7080

gtcggcgcca agggccgggg cgagagcgtg tggctggcgt ggtttttggc ggatgtggtg   7140

cggcgggtgg ccgagatcga ccatccggag ttcgcgcaac accgtgcgcg ctggcttgcg   7200

atgcgcgagc gggttctcgc ggcggcgaac gagtcggcgt gggatggaca gtggtaccgg   7260

cgcgccatca cggacgatgg gctgtggctg ggatcggccg cctcgcccgc gtgccgggtg   7320

gacgccatcg cgcagtcgtg ggcggtcatc tcgggaggag ctccgccgga tcgggccgtg   7380

cgcgccatgg agtcgttcga tcgggaactc gtggaccggc ggctcggtgt ggctcatctc   7440

ctccagccag catttcgaga tctgcgcccg agtcctggct acatccaagg ctatccgccg   7500

ggaatccgcg agaacggtgg gcagtacaca cacggggtca tctggagtgt catcgcgtgg   7560

acgcggcttg ggagggcaga cgaggcgtat gaactgttct ccatgctgaa cccgattcat   7620

cacgccgaca cgccgcgcga agtggagcgg tacgggaacg aaccgtatgt gatgtcggcg   7680

gacgtctaca cggcggaacc gaacgtgggg cagggcggct ggtcctggta cacaggcgcc   7740

gcctcgtgga tgtaccaggc gggactggag gccatcctcg gcatacggag gcatgggacg   7800

aggttgctcg tggagccgtg cgtccccgcg cattggcctg gctttgaggt ggcgtatcgg   7860

tacggttcaa cgctgtaccg cattcgcgtg gagcgagcgc cacaaggcgc ggaggcgcgc   7920

gacagcgcgc tcacagtgga aggcgtggct ccggccgaga tcgatctcgt cgacgatggt   7980

caggaacacc acgtggttgt gtggctcgcg gccgaagggg ctgaggtctt aagcgatgtt   8040

cagacggtgg cggctaggcc gcgcgagggc gcccggcggt accgcatgtc gagcggcgcg   8100

cgcgcgttcc ccgcgagcgc ggcgtaccga aagcgcgacc cacaaccgta a            8151


<210>  209
<211>  8151
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 201

<400>  209
atggcgttcg acacagaggt cgagaggcgc gcgcatgcat tggcgctgac gcaagacatc     60

agttcgacgc gcggcggggg atccgacctg tggcccatct tgcgccgaaa ggcggcccgg    120

gtgcggaatc tcgccaccag gctcgagcga gagcctgcgg cgtgttctga gcccgcgcac    180

gagtggctga tcgatcacgc cgcctatctc gaactccagg cgatgttggc ggagcgcctg    240

tggccgaacg ccgtggtgcg gaaactgccg aggatggccg agaccgggga gccccgcgtg    300

gtgaccctcg ccgcggccta cctcgatgcg acgcgcggac acgtcgaagc cgagacgctc    360

atccggtttg tcgaggcgta ccaggacgtc caggttctga cgacgcacga gtgtcaccag    420

ctggccaacg gcctgcgcgt cgcgatcctc acgcggctcg ccgaagcgag cgatgagata    480

cagcatcggt acgagacgtg tcgcgcggtc ggccgcttgc tcgacgagat cgagcgggga    540

gacgggccag tggccgtgcg ccgcgccatc gaccgctttt ctaagggacg tgggcttggc    600

gccgtggagg tggtgcatct cgtgcatcac ctgtccgagt gggagccgga cagccaggag    660

ctgcgcgagt ggctggcggc gcacgtcgcc aactcttccg agagcatcga gcggctgacg    720

acgtacgagg ccgagtggca cgccgaaatc caggtgctca tcggcaatct ggtgcagagc    780

ctgcacgcgc tggagcgcat gtcctggcag cccatcgcct cgcgcatctc ccgggtggag    840

tcctgcctgc ggcaagaacc gacgggcgac tacctgcggc tcgatccgac gagccagaac    900

gtgctcacgc agcaggtcag ctggctcagc gaggccttcc gcctgcccga ggcgatgatc    960

gccgagaccg ccgtctcgtt ggcgcgagag gcctgggaga aggccggatc gcccaccgcc   1020

tcgagcgacc tgccgcggga ggcgtttgtc gcgtactatc tgtgcgatcc cgacgggatg   1080

cacgcgcttc accgatcgct caaggagcgc gcgaagccga gatcagttcc gcagattgca   1140

cttcgccgcc gtccccttcg ttcgtacctc cttggtgtgg cgtttctgtt cgcggccatc   1200

ctgtgggcgg tgctcggggg gttcacgggc ggatttcgcg cgccccttgg ggcgacgctg   1260

gcgcttgccg tcctgctcgc gcttcccgtc agcgaatggg tcatttcgct cgtgcacgag   1320

gggatacgcc gcgccgttcg gcctgtgcct ctcctgcgcc tcgacttcag cgaggggatt   1380

ccggaggacg cgcgcaccct gatcgtgctc cccgtcattt gggcgagcga ggccgacgtc   1440

gacgaggcgt ttgacaagat cgagcttcac cacctgacga accgcggggc ccatctctac   1500

ttcgcggtgc tctcggacct ccgggacgcc gacgcgccgc acctgccgga ggacgagcct   1560

ttgctcgccc gggcgcgcgc gcgcctggag gcgctgcggc acaagtacgg agccgctcgc   1620

ttcttttggt tccaccgcga tcgcgtcctc aaccgcgcgg acggcgtcta catgggctgg   1680

gagcgaaagc gaggcaagct ggtggagttt gtcgagctgc ttcgcggcaa gcgcgacacg   1740

accttccgcg tgaaagacgg cgatctcgcc gtgctgccga cgattcgcta cgtgttcacc   1800

gcggatctcg acaccgaact gcccattggc accgtgcagc gccttgtcgg caccatgcac   1860

ctgccataca accggccgcg gctcaacgcc cgtggcacgc gggtggacca gggctacggc   1920

gtgctccagc cggccgtcgc cgtcagcccg cgctcgaccc aggcctcccg attcgcgcgc   1980

ctctggtcgg gcgagacggg cgtggatccg tacgcgttcg ccatctccaa cccttatcag   2040

gattggttcg ggcgcggcct gttcgtcggc aaggggctta tccacgtcga cgcgtttcac   2100

accgtgctgt gcgatcgcat cccggacaac cgggtcttaa gccacgacat cctcgaaggc   2160

gggtttttgc gcgccggcct cgtggcggac gtggaggtgg tcgagagcca gccggcgacg   2220

ctgcgcgcct acatgcgccg cgcccatcgg tgggtgcgtg gagactggca gctgacgtat   2280

tggttgcgcc gggtgtgtcg cgatcggcgc ggggagacgc agcctgtgga tttgtgcggc   2340

ttcacgcgct ggaacatcgt cgatcacgtc cggcacagcc tggtcaaccc cgcgctcgtc   2400

ctgctcatgg gctccggcat gtcagggctt ttgcccggcc cagcgtacgc atacggcgcc   2460

gtgctcctta tcaccgtgtt tttgcccttt ttgcgccagc ttgagtccat ccggcccggc   2520

gaatgggact ggaggagcgc cgcgacggcg cttggccaga gcctggtcat gctcgtgacg   2580

ctgccgttca tggcggtggt cgaggcggac gccagcctgc gcgctctgta tcggatgctc   2640

gtcagccgac ggcggctgct cgagtggatc ccctcctctc acgcggaccg gtcggacgga   2700

tcgcccgcgc ctcttctcta cgagccggcg ggttacgcgg tcgcgctggc gtgttcggtg   2760

cctgggctct tcggcacgtg ggaacaggcg ctctcgagca ccctcgcgct cgcggtgtgg   2820

ctgccggcgc acgccgtggc acgctttctg gcgaagcccg cgggagaagc gcgcgtcgcg   2880

gcgcccgatc ctgcactctc cgcgcacctg cgcgaggtgg ccacggcgat gtggcggttt   2940

tacgagcggt acgtcggcga agaagatcat cacctgccgc cggacaacgt gcagtttgag   3000

cccgtggagc ggatcgcgca ccgcacgtcg ccgaccaaca tcgggctcta tctcttgtgc   3060

gtcgccgcgg cggcggatct cgagatcatc ccgaaggaag gcgccatcgc ccgcctcgag   3120

cgaaccctgg cgacgctcac gtccctggat cgatggcatg ggcacctgtt caactggtac   3180

gacacgcgca cgctcaggcc cctcgcgccg aggtacgtct cgaccgtgga ctctggcaat   3240

ctggtctgcg cgatgctcgc cttggggcag gccctgcgcg aatgggcggc atccgacgcg   3300

gacatcgccc ctcgcgcgcg ccgccttgcg gacgcgatgg agggcttcgc gcgggagatc   3360

gattttcgtc ctttgtatcg cccggatctc aggctttttt cgttgggctt tcacgcggat   3420

cgaaacgagc tcgagaacat cgtctacgat ctcctcgcct ccgaggcgcg ccaggcaagc   3480

ttcatcgcca ttgcgagcgg ccaggtgccc gcgtcgcact ggttcgcgct gtcccgcacc   3540

atgacgcgcg cgggccggta ccagccgctt ttgtcctggt ccgggacgat gttcgaatat   3600

ctcatgcccg cgctcctgat gcgccatctc cctcacacgc tgtgggagga gacctaccgt   3660

ggtgtcgtgt ggagacagat cgcctacgcg cgagagcgcg gcgtcccgtt cggcatctcg   3720

gagagcggct tctacgcgtt cgatcgcgac ctcaactacc aataccgggc gtttggcgtg   3780

ccggggctcg ggctggaccg cggcctggag caacacctcg tggtggcgcc gtatgcgacc   3840

atgctggcgc ttcccttcgc ccctgaacag gtggccgagg cgctccggca attgcgggaa   3900

cttggagcgc tgggaccgta cggctattac gaggccgtcg acttcacggc gagccggctt   3960

ccgccgggag accggtacaa ggtggtgcag agcttcatgg cgcaccacca gggcatggcg   4020

ttcatcgcca tcgccaacta cctgaatcgc aacctttggg tggagcggtt ccatcgcctg   4080

ccgctggtgc gcgcggccga gtacatgctg tacgagcgta tgccgaagcg gcccgcgctg   4140

ctcctcaagc cggttcacgc cgcgcacgcg cccaacttcg atcgcccggt ctacgcgcgc   4200

cggcgaagtg gagacgatgt ggcctggaac gcggtctcca acggcagcct gacgagtttc   4260

gctgacgcgc gcggcgaggg cgggatcgcc tggcgcggca tcgcggtgac gcgctaccgg   4320

ccggatcggc acctgcccta tcgcggaccg gtcatgtacg tgcgagatgt cgatcgcggc   4380

ggcgtctttc gcaccaccct gcacggtggc ggcggacacg tagaggcgga gtttcgcccg   4440

gacaagtcga gttggaagcg cgtggtggac gggatcgaga gcgagtggtc ggtcctcgtg   4500

gccccggatc gagacgtgga gattcggacg ttggtccttc agaacctcgg ggaggacgtt   4560

cgccggctcg aggtgaccta tttcgccgaa ctcgcgcttg cgaagccggc tgcggacatc   4620

gcgcatccgt cgtttcagcg cctgttcgtc gagacgggat gggacgatgc gcgccaggtg   4680

ctgtgggccc agcgcaggcc cgagtcggac gatcagccag acgtgtacgc ggcgtttcac   4740

ctcgtcgcag acgaggaagc gccagcgccg gtggagtggg actcccatcg ggcgcggttc   4800

gtcggccgcg gcggcagcct cgcggcgccg cgggggctct ggcgccgtct gcgtggcgaa   4860

ggggtggccg atccggccgc gattctccgc acggccgtga ccctcgcacc cggggaaaag   4920

cgcgcgctct atgtcatcac cgcgctcggc gaggcgcggg acgaggtcgt ggagacggcg   4980

tttgaaatgc gccagccttc ggcccgatcg cgcgcggcgc agctcgcgtg gatgcgcgcg   5040

cagatcgatc tccgccagct gcacctttcg ccggacgatg tcgaggacgc catggaactt   5100

ctgtcgcggt tcttgtcccg gcacgcgttt tcgcccgagc ggcgggcggc cattctgcag   5160

aacgagcttg gccaatccgg gctctgggcg cacgggattt ccggcgatcg acccatcgtc   5220

gccgtccggc tcgcctccgc ggcggaggtc ccgtttgtcg cgaagctcgc gcggctcacg   5280

cagtatcttg cgcacatggg cttcgcgagc gatctcgtcg tgatcgacga gacgatatcc   5340

agctatcgag acgagatgcg ggatcggatc cgggcggaga tggcgcgccg cggcgtgcac   5400

gacgcggcga ccctcgccgt ggtgaaggcg gatcagcttt cgagcgccga gcgggcgctc   5460

atggaatcgg tggctgtcgc gacgttgcgg gccggtgggc cgagcgtcgg cgcgcagctc   5520

acgggcggac gggtgcggcg cgaggaatcg gcgagactcg cgtcggaccg cctggagccg   5580

gagccgaaac gcgcgccgcg cgatgcgggg caggtggagg gagagtttgc gaacggctat   5640

ggcgcgttcg tcgacgacgg tcgcgcgtac cgcatgcgtg tgacgcgcgc caagcggccc   5700

ccgcggccct ggtcgaacgt gcttgccaat cccaacttcg gcgcgctcgt gactgagctc   5760

ggcaccggct acacctggtg gcgcaacagc cgcgagttca agctcacgcc ctggcacaac   5820

gatgccgcct tcgacccgcc cggcgaggcc gtgtacatcg ccgatctcga ccgcggaatc   5880

atcgcgagcg ccaccccttc gcccgccggc gatgaacgga cgtacgacgt gacgcatcgg   5940

cccggcgtca ccacgtttga aagcgacgtg gagggcgtcc gcgtcacgct tcatgtgttc   6000

gtcgattctg ccgagcccgc gaagtggatg cgggtgcggc ttcgcaacca aagcggggag   6060

gagcgcagaa tccgcgtggc cccgtatgcc gaatgggtgc tcggcgtgga tccgttctcg   6120

aacacgcccc tcgtcgtggt gcggaagatg ggcgaagcgg atgccatcgc tgcggaaaac   6180

cggtatcagg aggcgtttcg cggcgccttg ggctttctgg ccgtgggcgg cgccggacgg   6240

acaacggggt ggttgggaga caagacgcgc ttcctcggcg acggatcgta tgctcggccc   6300

gacgcgctgc tcgaggacgc gtggcgcggg ggagacggcc ccacgccgac gccctgcgcc   6360

gtccttgcgc gcgatctcga ccttgggccg catgaggagg ccgaggtggt catcctcctt   6420

ggcgcggcgc ctgacgaaca cgaggccgcg aggctcgccc ggctcgccga cccggccgcg   6480

gcggatcgcg cgcttcgcga ggtcactaga ttctgggatg atcttcttgg gcgtgtccaa   6540

atccgcacac cggatcgcgc cttcgacatc ctgatgaacg gctggctcgt gtaccaggcc   6600

ctcgcctgcc gcctctgggc ccgcacggcc ttttaccagg ccggcggcgc gttcggcttt   6660

cgcgatcagc tgcaggacgc cctcgcgctg attcacgctc gacccgacat cctgcgcgat   6720

cagatcctgc gggcggcgcg ccatcagtac gtcgagggcg acgtgcagca ctggtggcat   6780

gaggagttgg gcaaaggcat ccgcacgcgc ttttcggacg atttgctttg gcttccgtac   6840

gcggtctcgc gttacctcga ggcgacgggc gatgccgcgc tcctcgatga acgcgcgccg   6900

tatctcgtga gcgccccgct tggcgacggc gaactcgagc gatacgagga cagcgtctgg   6960

agccaggagg aaggcaccct cgcggaacac gtcgcgcggg ctgtggagcg cgcgcttcac   7020

ttcggcgatc acggcctccc gctcatcggc atcggcgact ggaacgacgg cctgagccga   7080

gtcggcgcca agggccgggg cgagagcgtg tggctggcgt ggtttttggc ggatgtggtg   7140

cggcgggtgg ccgagatcga ccatccggag ttcgcgcaac accgtgcgcg ctggcttgcg   7200

atgcgcgagc gggttctcgc ggcggcgaac gagtcggcgt gggatggaca gtggtaccgg   7260

cgcgccatca cggacgatgg gctgtggctg ggatcggccg cctcgcccgc gtgccgggtg   7320

gacgccatcg cgcagtcgtg ggcggtcatc tcgggaggag ctccgccgga tcgggccgtg   7380

cgcgccatgg agtcgttcga tcgggaactc gtggaccggc ggctcggtgt ggctcatctc   7440

ctccagccag catttcgaga tctgcgcccg agtcctggct acatccaagg ctatccgccg   7500

ggaatccgcg agaacggtgg gcagtacaca cacggggtca tctggagtgt catcgcgtgg   7560

acgcggcttg ggagggcaga cgaggcgtat gaactgttct ccatgctgaa cccgattcat   7620

cacgccgaca cgccgcgcga agtggagcgg tacgggaacg aaccgtatgt gatgtcggcg   7680

gacgtctaca cggcggaacc gaacgtgggg cagggcggct ggtcctggta cacaggcgcc   7740

gcctcgtgga tgtaccaggc gggactggag gccatcctcg gcatacggag gcatgggacg   7800

aggttgctcg tggagccgtg cgtccccgcg cattggcctg gctttgaggt ggcgtatcgg   7860

tacggttcaa cgctgtaccg cattcgcgtg gagcgagcgc cacaaggcgc ggaggcgcgc   7920

gacagcgcgc tcacagtgga aggcgtggct ccggccgaga tcgatctcgt cgacgatggt   7980

caggaacacc acgtggttgt gtggctcgcg gccgaagggg ctgaggtctt aagcgatgtt   8040

cagacggtgg cggctaggcc gcgcgagggc gcccggcggt accgcatgtc gagcggcgcg   8100

cgcgcgttcc ccgcgagcgc ggcgtaccga aagcgcgacc cacaaccgta a            8151


<210>  210
<211>  8151
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 201

<400>  210
atggcgttcg acacagagct cgagaagcgc gcgcatgcat tggcgctgac gcaagacatc     60

agttcgacgc gcggcggggg atccgacctg tggcccatct tgcgccgaaa ggcggcccgg    120

gtgcggaatc tcgccaccag gctcgagcga gagcctgcgg cgtgttctga gcccgcgcac    180

gagtggctga tcgatcacgc cgcctatctc gaactccagg cgatgttggc ggagcgcctg    240

tggccgaacg ccgtggtgcg gaaactgccg aggatggccg agaccgggga gccccgcgtg    300

gtgaccctcg ccgcggccta cctcgatgcg acgcgcggac acgtcgaagc cgagacgctc    360

atccggtttg tcgaggcgta ccaggacgtc caggttctga cgacgcacga gtgtcaccag    420

ctggccaacg gcctgcgcgt cgcgatcctc acgcggctcg ccgaagcgag cgatgagata    480

cagcatcggt acgagacgtg tcgcgcggtc ggccgcttgc tcgacgagat cgagcgggga    540

gacgggccag tggccgtgcg ccgcgccatc gaccgctttt ctaagggacg tgggcttggc    600

gccgtggagg tggtgcatct cgtgcatcac ctgtccgagt gggagccgga cagccaggag    660

ctgcgcgagt ggctggcggc gcacgtcgcc aactcttccg agagcatcga gcggctgacg    720

acgtacgagg ccgagtggca cgccgaaatc caggtgctca tcggcaatct ggtgcagagc    780

ctgcacgcgc tggagcgcat gtcctggcag cccatcgcct cgcgcatctc ccgggtggag    840

tcctgcctgc ggcaagaacc gacgggcgac tacctgcggc tcgatccgac gagccagaac    900

gtgctcacgc agcaggtcag ctggctcagc gaggccttcc gcctgcccga ggcgatgatc    960

gccgagaccg ccgtctcgtt ggcgcgagag gcctgggaga aggccggatc gcccaccgcc   1020

tcgagcgacc tgccgcggga ggcgtttgtc gcgtactatc tgtgcgatcc cgacgggatg   1080

cacgcgcttc accgatcgct caaggagcgc gcgaagccga gatcagttcc gcagattgca   1140

cttcgccgcc gtccccttcg ttcgtacctc cttggtgtgg cgtttctgtt cgcggccatc   1200

ctgtgggcgg tgctcggggg gttcacgggc ggatttcgcg cgccccttgg ggcgacgctg   1260

gcgcttgccg tcctgctcgc gcttcccgtc agcgaatggg tcatttcgct cgtgcacgag   1320

gggatacgcc gcgccgttcg gcctgtgcct ctcctgcgcc tcgacttcag cgaggggatt   1380

ccggaggacg cgcgcaccct gatcgtgctc cccgtcattt gggcgagcga ggccgacgtc   1440

gacgaggcgt ttgacaagat cgagcttcac cacctgacga accgcggggc ccatctctac   1500

ttcgcggtgc tctcggacct ccgggacgcc gacgcgccgc acctgccgga ggacgagcct   1560

ttgctcgccc gggcgcgcgc gcgcctggag gcgctgcggc acaagtacgg agccgctcgc   1620

ttcttttggt tccaccgcga tcgcgtcctc aaccgcgcgg acggcgtcta catgggctgg   1680

gagcgaaagc gaggcaagct ggtggagttt gtcgagctgc ttcgcggcaa gcgcgacacg   1740

accttccgcg tgaaagacgg cgatctcgcc gtgctgccga cgattcgcta cgtgttcacc   1800

gcggatctcg acaccgaact gcccattggc accgtgcagc gccttgtcgg caccatgcac   1860

ctgccataca accggccgcg gctcaacgcc cgtggcacgc gggtggacca gggctacggc   1920

gtgctccagc cggccgtcgc cgtcagcccg cgctcgaccc aggcctcccg attcgcgcgc   1980

ctctggtcgg gcgagacggg cgtggatccg tacgcgttcg ccatctccaa cccttatcag   2040

gattggttcg ggcgcggcct gttcgtcggc aaggggctta tccacgtcga cgcgtttcac   2100

accgtgctgt gcgatcgcat cccggacaac cgggtcttaa gccacgacat cctcgaaggc   2160

gggtttttgc gcgccggcct cgtggcggac gtggaggtgg tcgagagcca gccggcgacg   2220

ctgcgcgcct acatgcgccg cgcccatcgg tgggtgcgtg gagactggca gctgacgtat   2280

tggttgcgcc gggtgtgtcg cgatcggcgc ggggagacgc agcctgtgga tttgtgcggc   2340

ttcacgcgct ggaacatcgt cgatcacgtc cggcacagcc tggtcaaccc cgcgctcgtc   2400

ctgctcatgg gctccggcat gtcagggctt ttgcccggcc cagcgtacgc atacggcgcc   2460

gtgctcctta tcaccgtgtt tttgcccttt ttgcgccagc ttgagtccat ccggcccggc   2520

gaatgggact ggaggagcgc cgcgacggcg cttggccaga gcctggtcat gctcgtgacg   2580

ctgccgttca tggcggtggt cgaggcggac gccagcctgc gcgctctgta tcggatgctc   2640

gtcagccgac ggcggctgct cgagtggatc ccctcctctc acgcggaccg gtcggacgga   2700

tcgcccgcgc ctcttctcta cgagccggcg ggttacgcgg tcgcgctggc gtgttcggtg   2760

cctgggctct tcggcacgtg ggaacaggcg ctctcgagca ccctcgcgct cgcggtgtgg   2820

ctgccggcgc acgccgtggc acgctttctg gcgaagcccg cgggagaagc gcgcgtcgcg   2880

gcgcccgatc ctgcactctc cgcgcacctg cgcgaggtgg ccacggcgat gtggcggttt   2940

tacgagcggt acgtcggcga agaagatcat cacctgccgc cggacaacgt gcagtttgag   3000

cccgtggagc ggatcgcgca ccgcacgtcg ccgaccaaca tcgggctcta tctcttgtgc   3060

gtcgccgcgg cggcggatct cgagatcatc ccgaaggaag gcgccatcgc ccgcctcgag   3120

cgaaccctgg cgacgctcac gtccctggat cgatggcatg ggcacctgtt caactggtac   3180

gacacgcgca cgctcaggcc cctcgcgccg aggtacgtct cgaccgtgga ctctggcaat   3240

ctggtctgcg cgatgctcgc cttggggcag gccctgcgcg aatgggcggc atccgacgcg   3300

gacatcgccc ctcgcgcgcg ccgccttgcg gacgcgatgg agggcttcgc gcgggagatc   3360

gattttcgtc ctttgtatcg cccggatctc aggctttttt cgttgggctt tcacgcggat   3420

cgaaacgagc tcgagaacat cgtctacgat ctcctcgcct ccgaggcgcg ccaggcaagc   3480

ttcatcgcca ttgcgagcgg ccaggtgccc gcgtcgcact ggttcgcgct gtcccgcacc   3540

atgacgcgcg cgggccggta ccagccgctt ttgtcctggt ccgggacgat gttcgaatat   3600

ctcatgcccg cgctcctgat gcgccatctc cctcacacgc tgtgggagga gacctaccgt   3660

ggtgtcgtgt ggagacagat cgcctacgcg cgagagcgcg gcgtcccgtt cggcatctcg   3720

gagagcggct tctacgcgtt cgatcgcgac ctcaactacc aataccgggc gtttggcgtg   3780

ccggggctcg ggctggaccg cggcctggag caacacctcg tggtggcgcc gtatgcgacc   3840

atgctggcgc ttcccttcgc ccctgaacag gtggccgagg cgctccggca attgcgggaa   3900

cttggagcgc tgggaccgta cggctattac gaggccgtcg acttcacggc gagccggctt   3960

ccgccgggag accggtacaa ggtggtgcag agcttcatgg cgcaccacca gggcatggcg   4020

ttcatcgcca tcgccaacta cctgaatcgc aacctttggg tggagcggtt ccatcgcctg   4080

ccgctggtgc gcgcggccga gtacatgctg tacgagcgta tgccgaagcg gcccgcgctg   4140

ctcctcaagc cggttcacgc cgcgcacgcg cccaacttcg atcgcccggt ctacgcgcgc   4200

cggcgaagtg gagacgatgt ggcctggaac gcggtctcca acggcagcct gacgagtttc   4260

gctgacgcgc gcggcgaggg cgggatcgcc tggcgcggca tcgcggtgac gcgctaccgg   4320

ccggatcggc acctgcccta tcgcggaccg gtcatgtacg tgcgagatgt cgatcgcggc   4380

ggcgtctttc gcaccaccct gcacggtggc ggcggacacg tagaggcgga gtttcgcccg   4440

gacaagtcga gttggaagcg cgtggtggac gggatcgaga gcgagtggtc ggtcctcgtg   4500

gccccggatc gagacgtgga gattcggacg ttggtccttc agaacctcgg ggaggacgtt   4560

cgccggctcg aggtgaccta tttcgccgaa ctcgcgcttg cgaagccggc tgcggacatc   4620

gcgcatccgt cgtttcagcg cctgttcgtc gagacgggat gggacgatgc gcgccaggtg   4680

ctgtgggccc agcgcaggcc cgagtcggac gatcagccag acgtgtacgc ggcgtttcac   4740

ctcgtcgcag acgaggaagc gccagcgccg gtggagtggg actcccatcg ggcgcggttc   4800

gtcggccgcg gcggcagcct cgcggcgccg cgggggctct ggcgccgtct gcgtggcgaa   4860

ggggtggccg atccggccgc gattctccgc acggccgtga ccctcgcacc cggggaaaag   4920

cgcgcgctct atgtcatcac cgcgctcggc gaggcgcggg acgaggtcgt ggagacggcg   4980

tttgaaatgc gccagccttc ggcccgatcg cgcgcggcgc agctcgcgtg gatgcgcgcg   5040

cagatcgatc tccgccagct gcacctttcg ccggacgatg tcgaggacgc catggaactt   5100

ctgtcgcggt tcttgtcccg gcacgcgttt tcgcccgagc ggcgggcggc cattctgcag   5160

aacgagcttg gccaatccgg gctctgggcg cacgggattt ccggcgatcg acccatcgtc   5220

gccgtccggc tcgcctccgc ggcggaggtc ccgtttgtcg cgaagctcgc gcggctcacg   5280

cagtatcttg cgcacatggg cttcgcgagc gatctcgtcg tgatcgacga gacgatatcc   5340

agctatcgag acgagatgcg ggatcggatc cgggcggaga tggcgcgccg cggcgtgcac   5400

gacgcggcga ccctcgccgt ggtgaaggcg gatcagcttt cgagcgccga gcgggcgctc   5460

atggaatcgg tggctgtcgc gacgttgcgg gccggtgggc cgagcgtcgg cgcgcagctc   5520

acgggcggac gggtgcggcg cgaggaatcg gcgagactcg cgtcggaccg cctggagccg   5580

gagccgaaac gcgcgccgcg cgatgcgggg caggtggagg gagagtttgc gaacggctat   5640

ggcgcgttcg tcgacgacgg tcgcgcgtac cgcatgcgtg tgacgcgcgc caagcggccc   5700

ccgcggccct ggtcgaacgt gcttgccaat cccaacttcg gcgcgctcgt gactgagctc   5760

ggcaccggct acacctggtg gcgcaacagc cgcgagttca agctcacgcc ctggcacaac   5820

gatgccgcct tcgacccgcc cggcgaggcc gtgtacatcg ccgatctcga ccgcggaatc   5880

atcgcgagcg ccaccccttc gcccgccggc gatgaacgga cgtacgacgt gacgcatcgg   5940

cccggcgtca ccacgtttga aagcgacgtg gagggcgtcc gcgtcacgct tcatgtgttc   6000

gtcgattctg ccgagcccgc gaagtggatg cgggtgcggc ttcgcaacca aagcggggag   6060

gagcgcagaa tccgcgtggc cccgtatgcc gaatgggtgc tcggcgtgga tccgttctcg   6120

aacacgcccc tcgtcgtggt gcggaagatg ggcgaagcgg atgccatcgc tgcggaaaac   6180

cggtatcagg aggcgtttcg cggcgccttg ggctttctgg ccgtgggcgg cgccggacgg   6240

acaacggggt ggttgggaga caagacgcgc ttcctcggcg acggatcgta tgctcggccc   6300

gacgcgctgc tcgaggacgc gtggcgcggg ggagacggcc ccacgccgac gccctgcgcc   6360

gtccttgcgc gcgatctcga ccttgggccg catgaggagg ccgaggtggt catcctcctt   6420

ggcgcggcgc ctgacgaaca cgaggccgcg aggctcgccc ggctcgccga cccggccgcg   6480

gcggatcgcg cgcttcgcga ggtcactaga ttctgggatg atcttcttgg gcgtgtccaa   6540

atccgcacac cggatcgcgc cttcgacatc ctgatgaacg gctggctcgt gtaccaggcc   6600

ctcgcctgcc gcctctgggc ccgcacggcc ttttaccagg ccggcggcgc gttcggcttt   6660

cgcgatcagc tgcaggacgc cctcgcgctg attcacgctc gacccgacat cctgcgcgat   6720

cagatcctgc gggcggcgcg ccatcagtac gtcgagggcg acgtgcagca ctggtggcat   6780

gaggagttgg gcaaaggcat ccgcacgcgc ttttcggacg atttgctttg gcttccgtac   6840

gcggtctcgc gttacctcga ggcgacgggc gatgccgcgc tcctcgatga acgcgcgccg   6900

tatctcgtga gcgccccgct tggcgacggc gaactcgagc gatacgagga cagcgtctgg   6960

agccaggagg aaggcaccct cgcggaacac gtcgcgcggg ctgtggagcg cgcgcttcac   7020

ttcggcgatc acggcctccc gctcatcggc atcggcgact ggaacgacgg cctgagccga   7080

gtcggcgcca agggccgggg cgagagcgtg tggctggcgt ggtttttggc ggatgtggtg   7140

cggcgggtgg ccgagatcga ccatccggag ttcgcgcaac accgtgcgcg ctggcttgcg   7200

atgcgcgagc gggttctcgc ggcggcgaac gagtcggcgt gggatggaca gtggtaccgg   7260

cgcgccatca cggacgatgg gctgtggctg ggatcggccg cctcgcccgc gtgccgggtg   7320

gacgccatcg cgcagtcgtg ggcggtcatc tcgggaggag ctccgccgga tcgggccgtg   7380

cgcgccatgg agtcgttcga tcgggaactc gtggaccggc ggctcggtgt ggctcatctc   7440

ctccagccag catttcgaga tctgcgcccg agtcctggct acatccaagg ctatccgccg   7500

ggaatccgcg agaacggtgg gcagtacaca cacggggtca tctggagtgt catcgcgtgg   7560

acgcggcttg ggagggcaga cgaggcgtat gaactgttct ccatgctgaa cccgattcat   7620

cacgccgaca cgccgcgcga agtggagcgg tacgggaacg aaccgtatgt gatgtcggcg   7680

gacgtctaca cggcggaacc gaacgtgggg cagggcggct ggtcctggta cacaggcgcc   7740

gcctcgtgga tgtaccaggc gggactggag gccatcctcg gcatacggag gcatgggacg   7800

aggttgctcg tggagccgtg cgtccccgcg cattggcctg gctttgaggt ggcgtatcgg   7860

tacggttcaa cgctgtaccg cattcgcgtg gagcgagcgc cacaaggcgc ggaggcgcgc   7920

gacagcgcgc tcacagtgga aggcgtggct ccggccgaga tcgatctcgt cgacgatggt   7980

caggaacacc acgtggttgt gtggctcgcg gccgaagggg ctgaggtctt aagcgatgtt   8040

cagacggtgg cggctaggcc gcgcgagggc gcccggcggt accgcatgtc gagcggcgcg   8100

cgcgcgttcc ccgcgagcgc ggcgtaccga aagcgcgacc cacaaccgta a            8151


<210>  211
<211>  8151
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 201

<400>  211
atggcgttcg acacagagct cgagaggaaa gcgcatgcat tggcgctgac gcaagacatc     60

agttcgacgc gcggcggggg atccgacctg tggcccatct tgcgccgaaa ggcggcccgg    120

gtgcggaatc tcgccaccag gctcgagcga gagcctgcgg cgtgttctga gcccgcgcac    180

gagtggctga tcgatcacgc cgcctatctc gaactccagg cgatgttggc ggagcgcctg    240

tggccgaacg ccgtggtgcg gaaactgccg aggatggccg agaccgggga gccccgcgtg    300

gtgaccctcg ccgcggccta cctcgatgcg acgcgcggac acgtcgaagc cgagacgctc    360

atccggtttg tcgaggcgta ccaggacgtc caggttctga cgacgcacga gtgtcaccag    420

ctggccaacg gcctgcgcgt cgcgatcctc acgcggctcg ccgaagcgag cgatgagata    480

cagcatcggt acgagacgtg tcgcgcggtc ggccgcttgc tcgacgagat cgagcgggga    540

gacgggccag tggccgtgcg ccgcgccatc gaccgctttt ctaagggacg tgggcttggc    600

gccgtggagg tggtgcatct cgtgcatcac ctgtccgagt gggagccgga cagccaggag    660

ctgcgcgagt ggctggcggc gcacgtcgcc aactcttccg agagcatcga gcggctgacg    720

acgtacgagg ccgagtggca cgccgaaatc caggtgctca tcggcaatct ggtgcagagc    780

ctgcacgcgc tggagcgcat gtcctggcag cccatcgcct cgcgcatctc ccgggtggag    840

tcctgcctgc ggcaagaacc gacgggcgac tacctgcggc tcgatccgac gagccagaac    900

gtgctcacgc agcaggtcag ctggctcagc gaggccttcc gcctgcccga ggcgatgatc    960

gccgagaccg ccgtctcgtt ggcgcgagag gcctgggaga aggccggatc gcccaccgcc   1020

tcgagcgacc tgccgcggga ggcgtttgtc gcgtactatc tgtgcgatcc cgacgggatg   1080

cacgcgcttc accgatcgct caaggagcgc gcgaagccga gatcagttcc gcagattgca   1140

cttcgccgcc gtccccttcg ttcgtacctc cttggtgtgg cgtttctgtt cgcggccatc   1200

ctgtgggcgg tgctcggggg gttcacgggc ggatttcgcg cgccccttgg ggcgacgctg   1260

gcgcttgccg tcctgctcgc gcttcccgtc agcgaatggg tcatttcgct cgtgcacgag   1320

gggatacgcc gcgccgttcg gcctgtgcct ctcctgcgcc tcgacttcag cgaggggatt   1380

ccggaggacg cgcgcaccct gatcgtgctc cccgtcattt gggcgagcga ggccgacgtc   1440

gacgaggcgt ttgacaagat cgagcttcac cacctgacga accgcggggc ccatctctac   1500

ttcgcggtgc tctcggacct ccgggacgcc gacgcgccgc acctgccgga ggacgagcct   1560

ttgctcgccc gggcgcgcgc gcgcctggag gcgctgcggc acaagtacgg agccgctcgc   1620

ttcttttggt tccaccgcga tcgcgtcctc aaccgcgcgg acggcgtcta catgggctgg   1680

gagcgaaagc gaggcaagct ggtggagttt gtcgagctgc ttcgcggcaa gcgcgacacg   1740

accttccgcg tgaaagacgg cgatctcgcc gtgctgccga cgattcgcta cgtgttcacc   1800

gcggatctcg acaccgaact gcccattggc accgtgcagc gccttgtcgg caccatgcac   1860

ctgccataca accggccgcg gctcaacgcc cgtggcacgc gggtggacca gggctacggc   1920

gtgctccagc cggccgtcgc cgtcagcccg cgctcgaccc aggcctcccg attcgcgcgc   1980

ctctggtcgg gcgagacggg cgtggatccg tacgcgttcg ccatctccaa cccttatcag   2040

gattggttcg ggcgcggcct gttcgtcggc aaggggctta tccacgtcga cgcgtttcac   2100

accgtgctgt gcgatcgcat cccggacaac cgggtcttaa gccacgacat cctcgaaggc   2160

gggtttttgc gcgccggcct cgtggcggac gtggaggtgg tcgagagcca gccggcgacg   2220

ctgcgcgcct acatgcgccg cgcccatcgg tgggtgcgtg gagactggca gctgacgtat   2280

tggttgcgcc gggtgtgtcg cgatcggcgc ggggagacgc agcctgtgga tttgtgcggc   2340

ttcacgcgct ggaacatcgt cgatcacgtc cggcacagcc tggtcaaccc cgcgctcgtc   2400

ctgctcatgg gctccggcat gtcagggctt ttgcccggcc cagcgtacgc atacggcgcc   2460

gtgctcctta tcaccgtgtt tttgcccttt ttgcgccagc ttgagtccat ccggcccggc   2520

gaatgggact ggaggagcgc cgcgacggcg cttggccaga gcctggtcat gctcgtgacg   2580

ctgccgttca tggcggtggt cgaggcggac gccagcctgc gcgctctgta tcggatgctc   2640

gtcagccgac ggcggctgct cgagtggatc ccctcctctc acgcggaccg gtcggacgga   2700

tcgcccgcgc ctcttctcta cgagccggcg ggttacgcgg tcgcgctggc gtgttcggtg   2760

cctgggctct tcggcacgtg ggaacaggcg ctctcgagca ccctcgcgct cgcggtgtgg   2820

ctgccggcgc acgccgtggc acgctttctg gcgaagcccg cgggagaagc gcgcgtcgcg   2880

gcgcccgatc ctgcactctc cgcgcacctg cgcgaggtgg ccacggcgat gtggcggttt   2940

tacgagcggt acgtcggcga agaagatcat cacctgccgc cggacaacgt gcagtttgag   3000

cccgtggagc ggatcgcgca ccgcacgtcg ccgaccaaca tcgggctcta tctcttgtgc   3060

gtcgccgcgg cggcggatct cgagatcatc ccgaaggaag gcgccatcgc ccgcctcgag   3120

cgaaccctgg cgacgctcac gtccctggat cgatggcatg ggcacctgtt caactggtac   3180

gacacgcgca cgctcaggcc cctcgcgccg aggtacgtct cgaccgtgga ctctggcaat   3240

ctggtctgcg cgatgctcgc cttggggcag gccctgcgcg aatgggcggc atccgacgcg   3300

gacatcgccc ctcgcgcgcg ccgccttgcg gacgcgatgg agggcttcgc gcgggagatc   3360

gattttcgtc ctttgtatcg cccggatctc aggctttttt cgttgggctt tcacgcggat   3420

cgaaacgagc tcgagaacat cgtctacgat ctcctcgcct ccgaggcgcg ccaggcaagc   3480

ttcatcgcca ttgcgagcgg ccaggtgccc gcgtcgcact ggttcgcgct gtcccgcacc   3540

atgacgcgcg cgggccggta ccagccgctt ttgtcctggt ccgggacgat gttcgaatat   3600

ctcatgcccg cgctcctgat gcgccatctc cctcacacgc tgtgggagga gacctaccgt   3660

ggtgtcgtgt ggagacagat cgcctacgcg cgagagcgcg gcgtcccgtt cggcatctcg   3720

gagagcggct tctacgcgtt cgatcgcgac ctcaactacc aataccgggc gtttggcgtg   3780

ccggggctcg ggctggaccg cggcctggag caacacctcg tggtggcgcc gtatgcgacc   3840

atgctggcgc ttcccttcgc ccctgaacag gtggccgagg cgctccggca attgcgggaa   3900

cttggagcgc tgggaccgta cggctattac gaggccgtcg acttcacggc gagccggctt   3960

ccgccgggag accggtacaa ggtggtgcag agcttcatgg cgcaccacca gggcatggcg   4020

ttcatcgcca tcgccaacta cctgaatcgc aacctttggg tggagcggtt ccatcgcctg   4080

ccgctggtgc gcgcggccga gtacatgctg tacgagcgta tgccgaagcg gcccgcgctg   4140

ctcctcaagc cggttcacgc cgcgcacgcg cccaacttcg atcgcccggt ctacgcgcgc   4200

cggcgaagtg gagacgatgt ggcctggaac gcggtctcca acggcagcct gacgagtttc   4260

gctgacgcgc gcggcgaggg cgggatcgcc tggcgcggca tcgcggtgac gcgctaccgg   4320

ccggatcggc acctgcccta tcgcggaccg gtcatgtacg tgcgagatgt cgatcgcggc   4380

ggcgtctttc gcaccaccct gcacggtggc ggcggacacg tagaggcgga gtttcgcccg   4440

gacaagtcga gttggaagcg cgtggtggac gggatcgaga gcgagtggtc ggtcctcgtg   4500

gccccggatc gagacgtgga gattcggacg ttggtccttc agaacctcgg ggaggacgtt   4560

cgccggctcg aggtgaccta tttcgccgaa ctcgcgcttg cgaagccggc tgcggacatc   4620

gcgcatccgt cgtttcagcg cctgttcgtc gagacgggat gggacgatgc gcgccaggtg   4680

ctgtgggccc agcgcaggcc cgagtcggac gatcagccag acgtgtacgc ggcgtttcac   4740

ctcgtcgcag acgaggaagc gccagcgccg gtggagtggg actcccatcg ggcgcggttc   4800

gtcggccgcg gcggcagcct cgcggcgccg cgggggctct ggcgccgtct gcgtggcgaa   4860

ggggtggccg atccggccgc gattctccgc acggccgtga ccctcgcacc cggggaaaag   4920

cgcgcgctct atgtcatcac cgcgctcggc gaggcgcggg acgaggtcgt ggagacggcg   4980

tttgaaatgc gccagccttc ggcccgatcg cgcgcggcgc agctcgcgtg gatgcgcgcg   5040

cagatcgatc tccgccagct gcacctttcg ccggacgatg tcgaggacgc catggaactt   5100

ctgtcgcggt tcttgtcccg gcacgcgttt tcgcccgagc ggcgggcggc cattctgcag   5160

aacgagcttg gccaatccgg gctctgggcg cacgggattt ccggcgatcg acccatcgtc   5220

gccgtccggc tcgcctccgc ggcggaggtc ccgtttgtcg cgaagctcgc gcggctcacg   5280

cagtatcttg cgcacatggg cttcgcgagc gatctcgtcg tgatcgacga gacgatatcc   5340

agctatcgag acgagatgcg ggatcggatc cgggcggaga tggcgcgccg cggcgtgcac   5400

gacgcggcga ccctcgccgt ggtgaaggcg gatcagcttt cgagcgccga gcgggcgctc   5460

atggaatcgg tggctgtcgc gacgttgcgg gccggtgggc cgagcgtcgg cgcgcagctc   5520

acgggcggac gggtgcggcg cgaggaatcg gcgagactcg cgtcggaccg cctggagccg   5580

gagccgaaac gcgcgccgcg cgatgcgggg caggtggagg gagagtttgc gaacggctat   5640

ggcgcgttcg tcgacgacgg tcgcgcgtac cgcatgcgtg tgacgcgcgc caagcggccc   5700

ccgcggccct ggtcgaacgt gcttgccaat cccaacttcg gcgcgctcgt gactgagctc   5760

ggcaccggct acacctggtg gcgcaacagc cgcgagttca agctcacgcc ctggcacaac   5820

gatgccgcct tcgacccgcc cggcgaggcc gtgtacatcg ccgatctcga ccgcggaatc   5880

atcgcgagcg ccaccccttc gcccgccggc gatgaacgga cgtacgacgt gacgcatcgg   5940

cccggcgtca ccacgtttga aagcgacgtg gagggcgtcc gcgtcacgct tcatgtgttc   6000

gtcgattctg ccgagcccgc gaagtggatg cgggtgcggc ttcgcaacca aagcggggag   6060

gagcgcagaa tccgcgtggc cccgtatgcc gaatgggtgc tcggcgtgga tccgttctcg   6120

aacacgcccc tcgtcgtggt gcggaagatg ggcgaagcgg atgccatcgc tgcggaaaac   6180

cggtatcagg aggcgtttcg cggcgccttg ggctttctgg ccgtgggcgg cgccggacgg   6240

acaacggggt ggttgggaga caagacgcgc ttcctcggcg acggatcgta tgctcggccc   6300

gacgcgctgc tcgaggacgc gtggcgcggg ggagacggcc ccacgccgac gccctgcgcc   6360

gtccttgcgc gcgatctcga ccttgggccg catgaggagg ccgaggtggt catcctcctt   6420

ggcgcggcgc ctgacgaaca cgaggccgcg aggctcgccc ggctcgccga cccggccgcg   6480

gcggatcgcg cgcttcgcga ggtcactaga ttctgggatg atcttcttgg gcgtgtccaa   6540

atccgcacac cggatcgcgc cttcgacatc ctgatgaacg gctggctcgt gtaccaggcc   6600

ctcgcctgcc gcctctgggc ccgcacggcc ttttaccagg ccggcggcgc gttcggcttt   6660

cgcgatcagc tgcaggacgc cctcgcgctg attcacgctc gacccgacat cctgcgcgat   6720

cagatcctgc gggcggcgcg ccatcagtac gtcgagggcg acgtgcagca ctggtggcat   6780

gaggagttgg gcaaaggcat ccgcacgcgc ttttcggacg atttgctttg gcttccgtac   6840

gcggtctcgc gttacctcga ggcgacgggc gatgccgcgc tcctcgatga acgcgcgccg   6900

tatctcgtga gcgccccgct tggcgacggc gaactcgagc gatacgagga cagcgtctgg   6960

agccaggagg aaggcaccct cgcggaacac gtcgcgcggg ctgtggagcg cgcgcttcac   7020

ttcggcgatc acggcctccc gctcatcggc atcggcgact ggaacgacgg cctgagccga   7080

gtcggcgcca agggccgggg cgagagcgtg tggctggcgt ggtttttggc ggatgtggtg   7140

cggcgggtgg ccgagatcga ccatccggag ttcgcgcaac accgtgcgcg ctggcttgcg   7200

atgcgcgagc gggttctcgc ggcggcgaac gagtcggcgt gggatggaca gtggtaccgg   7260

cgcgccatca cggacgatgg gctgtggctg ggatcggccg cctcgcccgc gtgccgggtg   7320

gacgccatcg cgcagtcgtg ggcggtcatc tcgggaggag ctccgccgga tcgggccgtg   7380

cgcgccatgg agtcgttcga tcgggaactc gtggaccggc ggctcggtgt ggctcatctc   7440

ctccagccag catttcgaga tctgcgcccg agtcctggct acatccaagg ctatccgccg   7500

ggaatccgcg agaacggtgg gcagtacaca cacggggtca tctggagtgt catcgcgtgg   7560

acgcggcttg ggagggcaga cgaggcgtat gaactgttct ccatgctgaa cccgattcat   7620

cacgccgaca cgccgcgcga agtggagcgg tacgggaacg aaccgtatgt gatgtcggcg   7680

gacgtctaca cggcggaacc gaacgtgggg cagggcggct ggtcctggta cacaggcgcc   7740

gcctcgtgga tgtaccaggc gggactggag gccatcctcg gcatacggag gcatgggacg   7800

aggttgctcg tggagccgtg cgtccccgcg cattggcctg gctttgaggt ggcgtatcgg   7860

tacggttcaa cgctgtaccg cattcgcgtg gagcgagcgc cacaaggcgc ggaggcgcgc   7920

gacagcgcgc tcacagtgga aggcgtggct ccggccgaga tcgatctcgt cgacgatggt   7980

caggaacacc acgtggttgt gtggctcgcg gccgaagggg ctgaggtctt aagcgatgtt   8040

cagacggtgg cggctaggcc gcgcgagggc gcccggcggt accgcatgtc gagcggcgcg   8100

cgcgcgttcc ccgcgagcgc ggcgtaccga aagcgcgacc cacaaccgta a            8151


<210>  212
<211>  8151
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 201

<400>  212
atggcgttcg acacagagct cgagaggcgc gcgcatgcaa tagcgctgac gcaagacatc     60

agttcgacgc gcggcggggg atccgacctg tggcccatct tgcgccgaaa ggcggcccgg    120

gtgcggaatc tcgccaccag gctcgagcga gagcctgcgg cgtgttctga gcccgcgcac    180

gagtggctga tcgatcacgc cgcctatctc gaactccagg cgatgttggc ggagcgcctg    240

tggccgaacg ccgtggtgcg gaaactgccg aggatggccg agaccgggga gccccgcgtg    300

gtgaccctcg ccgcggccta cctcgatgcg acgcgcggac acgtcgaagc cgagacgctc    360

atccggtttg tcgaggcgta ccaggacgtc caggttctga cgacgcacga gtgtcaccag    420

ctggccaacg gcctgcgcgt cgcgatcctc acgcggctcg ccgaagcgag cgatgagata    480

cagcatcggt acgagacgtg tcgcgcggtc ggccgcttgc tcgacgagat cgagcgggga    540

gacgggccag tggccgtgcg ccgcgccatc gaccgctttt ctaagggacg tgggcttggc    600

gccgtggagg tggtgcatct cgtgcatcac ctgtccgagt gggagccgga cagccaggag    660

ctgcgcgagt ggctggcggc gcacgtcgcc aactcttccg agagcatcga gcggctgacg    720

acgtacgagg ccgagtggca cgccgaaatc caggtgctca tcggcaatct ggtgcagagc    780

ctgcacgcgc tggagcgcat gtcctggcag cccatcgcct cgcgcatctc ccgggtggag    840

tcctgcctgc ggcaagaacc gacgggcgac tacctgcggc tcgatccgac gagccagaac    900

gtgctcacgc agcaggtcag ctggctcagc gaggccttcc gcctgcccga ggcgatgatc    960

gccgagaccg ccgtctcgtt ggcgcgagag gcctgggaga aggccggatc gcccaccgcc   1020

tcgagcgacc tgccgcggga ggcgtttgtc gcgtactatc tgtgcgatcc cgacgggatg   1080

cacgcgcttc accgatcgct caaggagcgc gcgaagccga gatcagttcc gcagattgca   1140

cttcgccgcc gtccccttcg ttcgtacctc cttggtgtgg cgtttctgtt cgcggccatc   1200

ctgtgggcgg tgctcggggg gttcacgggc ggatttcgcg cgccccttgg ggcgacgctg   1260

gcgcttgccg tcctgctcgc gcttcccgtc agcgaatggg tcatttcgct cgtgcacgag   1320

gggatacgcc gcgccgttcg gcctgtgcct ctcctgcgcc tcgacttcag cgaggggatt   1380

ccggaggacg cgcgcaccct gatcgtgctc cccgtcattt gggcgagcga ggccgacgtc   1440

gacgaggcgt ttgacaagat cgagcttcac cacctgacga accgcggggc ccatctctac   1500

ttcgcggtgc tctcggacct ccgggacgcc gacgcgccgc acctgccgga ggacgagcct   1560

ttgctcgccc gggcgcgcgc gcgcctggag gcgctgcggc acaagtacgg agccgctcgc   1620

ttcttttggt tccaccgcga tcgcgtcctc aaccgcgcgg acggcgtcta catgggctgg   1680

gagcgaaagc gaggcaagct ggtggagttt gtcgagctgc ttcgcggcaa gcgcgacacg   1740

accttccgcg tgaaagacgg cgatctcgcc gtgctgccga cgattcgcta cgtgttcacc   1800

gcggatctcg acaccgaact gcccattggc accgtgcagc gccttgtcgg caccatgcac   1860

ctgccataca accggccgcg gctcaacgcc cgtggcacgc gggtggacca gggctacggc   1920

gtgctccagc cggccgtcgc cgtcagcccg cgctcgaccc aggcctcccg attcgcgcgc   1980

ctctggtcgg gcgagacggg cgtggatccg tacgcgttcg ccatctccaa cccttatcag   2040

gattggttcg ggcgcggcct gttcgtcggc aaggggctta tccacgtcga cgcgtttcac   2100

accgtgctgt gcgatcgcat cccggacaac cgggtcttaa gccacgacat cctcgaaggc   2160

gggtttttgc gcgccggcct cgtggcggac gtggaggtgg tcgagagcca gccggcgacg   2220

ctgcgcgcct acatgcgccg cgcccatcgg tgggtgcgtg gagactggca gctgacgtat   2280

tggttgcgcc gggtgtgtcg cgatcggcgc ggggagacgc agcctgtgga tttgtgcggc   2340

ttcacgcgct ggaacatcgt cgatcacgtc cggcacagcc tggtcaaccc cgcgctcgtc   2400

ctgctcatgg gctccggcat gtcagggctt ttgcccggcc cagcgtacgc atacggcgcc   2460

gtgctcctta tcaccgtgtt tttgcccttt ttgcgccagc ttgagtccat ccggcccggc   2520

gaatgggact ggaggagcgc cgcgacggcg cttggccaga gcctggtcat gctcgtgacg   2580

ctgccgttca tggcggtggt cgaggcggac gccagcctgc gcgctctgta tcggatgctc   2640

gtcagccgac ggcggctgct cgagtggatc ccctcctctc acgcggaccg gtcggacgga   2700

tcgcccgcgc ctcttctcta cgagccggcg ggttacgcgg tcgcgctggc gtgttcggtg   2760

cctgggctct tcggcacgtg ggaacaggcg ctctcgagca ccctcgcgct cgcggtgtgg   2820

ctgccggcgc acgccgtggc acgctttctg gcgaagcccg cgggagaagc gcgcgtcgcg   2880

gcgcccgatc ctgcactctc cgcgcacctg cgcgaggtgg ccacggcgat gtggcggttt   2940

tacgagcggt acgtcggcga agaagatcat cacctgccgc cggacaacgt gcagtttgag   3000

cccgtggagc ggatcgcgca ccgcacgtcg ccgaccaaca tcgggctcta tctcttgtgc   3060

gtcgccgcgg cggcggatct cgagatcatc ccgaaggaag gcgccatcgc ccgcctcgag   3120

cgaaccctgg cgacgctcac gtccctggat cgatggcatg ggcacctgtt caactggtac   3180

gacacgcgca cgctcaggcc cctcgcgccg aggtacgtct cgaccgtgga ctctggcaat   3240

ctggtctgcg cgatgctcgc cttggggcag gccctgcgcg aatgggcggc atccgacgcg   3300

gacatcgccc ctcgcgcgcg ccgccttgcg gacgcgatgg agggcttcgc gcgggagatc   3360

gattttcgtc ctttgtatcg cccggatctc aggctttttt cgttgggctt tcacgcggat   3420

cgaaacgagc tcgagaacat cgtctacgat ctcctcgcct ccgaggcgcg ccaggcaagc   3480

ttcatcgcca ttgcgagcgg ccaggtgccc gcgtcgcact ggttcgcgct gtcccgcacc   3540

atgacgcgcg cgggccggta ccagccgctt ttgtcctggt ccgggacgat gttcgaatat   3600

ctcatgcccg cgctcctgat gcgccatctc cctcacacgc tgtgggagga gacctaccgt   3660

ggtgtcgtgt ggagacagat cgcctacgcg cgagagcgcg gcgtcccgtt cggcatctcg   3720

gagagcggct tctacgcgtt cgatcgcgac ctcaactacc aataccgggc gtttggcgtg   3780

ccggggctcg ggctggaccg cggcctggag caacacctcg tggtggcgcc gtatgcgacc   3840

atgctggcgc ttcccttcgc ccctgaacag gtggccgagg cgctccggca attgcgggaa   3900

cttggagcgc tgggaccgta cggctattac gaggccgtcg acttcacggc gagccggctt   3960

ccgccgggag accggtacaa ggtggtgcag agcttcatgg cgcaccacca gggcatggcg   4020

ttcatcgcca tcgccaacta cctgaatcgc aacctttggg tggagcggtt ccatcgcctg   4080

ccgctggtgc gcgcggccga gtacatgctg tacgagcgta tgccgaagcg gcccgcgctg   4140

ctcctcaagc cggttcacgc cgcgcacgcg cccaacttcg atcgcccggt ctacgcgcgc   4200

cggcgaagtg gagacgatgt ggcctggaac gcggtctcca acggcagcct gacgagtttc   4260

gctgacgcgc gcggcgaggg cgggatcgcc tggcgcggca tcgcggtgac gcgctaccgg   4320

ccggatcggc acctgcccta tcgcggaccg gtcatgtacg tgcgagatgt cgatcgcggc   4380

ggcgtctttc gcaccaccct gcacggtggc ggcggacacg tagaggcgga gtttcgcccg   4440

gacaagtcga gttggaagcg cgtggtggac gggatcgaga gcgagtggtc ggtcctcgtg   4500

gccccggatc gagacgtgga gattcggacg ttggtccttc agaacctcgg ggaggacgtt   4560

cgccggctcg aggtgaccta tttcgccgaa ctcgcgcttg cgaagccggc tgcggacatc   4620

gcgcatccgt cgtttcagcg cctgttcgtc gagacgggat gggacgatgc gcgccaggtg   4680

ctgtgggccc agcgcaggcc cgagtcggac gatcagccag acgtgtacgc ggcgtttcac   4740

ctcgtcgcag acgaggaagc gccagcgccg gtggagtggg actcccatcg ggcgcggttc   4800

gtcggccgcg gcggcagcct cgcggcgccg cgggggctct ggcgccgtct gcgtggcgaa   4860

ggggtggccg atccggccgc gattctccgc acggccgtga ccctcgcacc cggggaaaag   4920

cgcgcgctct atgtcatcac cgcgctcggc gaggcgcggg acgaggtcgt ggagacggcg   4980

tttgaaatgc gccagccttc ggcccgatcg cgcgcggcgc agctcgcgtg gatgcgcgcg   5040

cagatcgatc tccgccagct gcacctttcg ccggacgatg tcgaggacgc catggaactt   5100

ctgtcgcggt tcttgtcccg gcacgcgttt tcgcccgagc ggcgggcggc cattctgcag   5160

aacgagcttg gccaatccgg gctctgggcg cacgggattt ccggcgatcg acccatcgtc   5220

gccgtccggc tcgcctccgc ggcggaggtc ccgtttgtcg cgaagctcgc gcggctcacg   5280

cagtatcttg cgcacatggg cttcgcgagc gatctcgtcg tgatcgacga gacgatatcc   5340

agctatcgag acgagatgcg ggatcggatc cgggcggaga tggcgcgccg cggcgtgcac   5400

gacgcggcga ccctcgccgt ggtgaaggcg gatcagcttt cgagcgccga gcgggcgctc   5460

atggaatcgg tggctgtcgc gacgttgcgg gccggtgggc cgagcgtcgg cgcgcagctc   5520

acgggcggac gggtgcggcg cgaggaatcg gcgagactcg cgtcggaccg cctggagccg   5580

gagccgaaac gcgcgccgcg cgatgcgggg caggtggagg gagagtttgc gaacggctat   5640

ggcgcgttcg tcgacgacgg tcgcgcgtac cgcatgcgtg tgacgcgcgc caagcggccc   5700

ccgcggccct ggtcgaacgt gcttgccaat cccaacttcg gcgcgctcgt gactgagctc   5760

ggcaccggct acacctggtg gcgcaacagc cgcgagttca agctcacgcc ctggcacaac   5820

gatgccgcct tcgacccgcc cggcgaggcc gtgtacatcg ccgatctcga ccgcggaatc   5880

atcgcgagcg ccaccccttc gcccgccggc gatgaacgga cgtacgacgt gacgcatcgg   5940

cccggcgtca ccacgtttga aagcgacgtg gagggcgtcc gcgtcacgct tcatgtgttc   6000

gtcgattctg ccgagcccgc gaagtggatg cgggtgcggc ttcgcaacca aagcggggag   6060

gagcgcagaa tccgcgtggc cccgtatgcc gaatgggtgc tcggcgtgga tccgttctcg   6120

aacacgcccc tcgtcgtggt gcggaagatg ggcgaagcgg atgccatcgc tgcggaaaac   6180

cggtatcagg aggcgtttcg cggcgccttg ggctttctgg ccgtgggcgg cgccggacgg   6240

acaacggggt ggttgggaga caagacgcgc ttcctcggcg acggatcgta tgctcggccc   6300

gacgcgctgc tcgaggacgc gtggcgcggg ggagacggcc ccacgccgac gccctgcgcc   6360

gtccttgcgc gcgatctcga ccttgggccg catgaggagg ccgaggtggt catcctcctt   6420

ggcgcggcgc ctgacgaaca cgaggccgcg aggctcgccc ggctcgccga cccggccgcg   6480

gcggatcgcg cgcttcgcga ggtcactaga ttctgggatg atcttcttgg gcgtgtccaa   6540

atccgcacac cggatcgcgc cttcgacatc ctgatgaacg gctggctcgt gtaccaggcc   6600

ctcgcctgcc gcctctgggc ccgcacggcc ttttaccagg ccggcggcgc gttcggcttt   6660

cgcgatcagc tgcaggacgc cctcgcgctg attcacgctc gacccgacat cctgcgcgat   6720

cagatcctgc gggcggcgcg ccatcagtac gtcgagggcg acgtgcagca ctggtggcat   6780

gaggagttgg gcaaaggcat ccgcacgcgc ttttcggacg atttgctttg gcttccgtac   6840

gcggtctcgc gttacctcga ggcgacgggc gatgccgcgc tcctcgatga acgcgcgccg   6900

tatctcgtga gcgccccgct tggcgacggc gaactcgagc gatacgagga cagcgtctgg   6960

agccaggagg aaggcaccct cgcggaacac gtcgcgcggg ctgtggagcg cgcgcttcac   7020

ttcggcgatc acggcctccc gctcatcggc atcggcgact ggaacgacgg cctgagccga   7080

gtcggcgcca agggccgggg cgagagcgtg tggctggcgt ggtttttggc ggatgtggtg   7140

cggcgggtgg ccgagatcga ccatccggag ttcgcgcaac accgtgcgcg ctggcttgcg   7200

atgcgcgagc gggttctcgc ggcggcgaac gagtcggcgt gggatggaca gtggtaccgg   7260

cgcgccatca cggacgatgg gctgtggctg ggatcggccg cctcgcccgc gtgccgggtg   7320

gacgccatcg cgcagtcgtg ggcggtcatc tcgggaggag ctccgccgga tcgggccgtg   7380

cgcgccatgg agtcgttcga tcgggaactc gtggaccggc ggctcggtgt ggctcatctc   7440

ctccagccag catttcgaga tctgcgcccg agtcctggct acatccaagg ctatccgccg   7500

ggaatccgcg agaacggtgg gcagtacaca cacggggtca tctggagtgt catcgcgtgg   7560

acgcggcttg ggagggcaga cgaggcgtat gaactgttct ccatgctgaa cccgattcat   7620

cacgccgaca cgccgcgcga agtggagcgg tacgggaacg aaccgtatgt gatgtcggcg   7680

gacgtctaca cggcggaacc gaacgtgggg cagggcggct ggtcctggta cacaggcgcc   7740

gcctcgtgga tgtaccaggc gggactggag gccatcctcg gcatacggag gcatgggacg   7800

aggttgctcg tggagccgtg cgtccccgcg cattggcctg gctttgaggt ggcgtatcgg   7860

tacggttcaa cgctgtaccg cattcgcgtg gagcgagcgc cacaaggcgc ggaggcgcgc   7920

gacagcgcgc tcacagtgga aggcgtggct ccggccgaga tcgatctcgt cgacgatggt   7980

caggaacacc acgtggttgt gtggctcgcg gccgaagggg ctgaggtctt aagcgatgtt   8040

cagacggtgg cggctaggcc gcgcgagggc gcccggcggt accgcatgtc gagcggcgcg   8100

cgcgcgttcc ccgcgagcgc ggcgtaccga aagcgcgacc cacaaccgta a            8151


<210>  213
<211>  2716
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:202 and encoded by SEQ ID NO:208

<400>  213

Met Ala Phe Asp Thr Glu Ile Glu Arg Arg Ala His Ala Leu Ala Leu 
1               5                   10                  15      


Thr Gln Asp Ile Ser Ser Thr Arg Gly Gly Gly Ser Asp Leu Trp Pro 
            20                  25                  30          


Ile Leu Arg Arg Lys Ala Ala Arg Val Arg Asn Leu Ala Thr Arg Leu 
        35                  40                  45              


Glu Arg Glu Pro Ala Ala Cys Ser Glu Pro Ala His Glu Trp Leu Ile 
    50                  55                  60                  


Asp His Ala Ala Tyr Leu Glu Leu Gln Ala Met Leu Ala Glu Arg Leu 
65                  70                  75                  80  


Trp Pro Asn Ala Val Val Arg Lys Leu Pro Arg Met Ala Glu Thr Gly 
                85                  90                  95      


Glu Pro Arg Val Val Thr Leu Ala Ala Ala Tyr Leu Asp Ala Thr Arg 
            100                 105                 110         


Gly His Val Glu Ala Glu Thr Leu Ile Arg Phe Val Glu Ala Tyr Gln 
        115                 120                 125             


Asp Val Gln Val Leu Thr Thr His Glu Cys His Gln Leu Ala Asn Gly 
    130                 135                 140                 


Leu Arg Val Ala Ile Leu Thr Arg Leu Ala Glu Ala Ser Asp Glu Ile 
145                 150                 155                 160 


Gln His Arg Tyr Glu Thr Cys Arg Ala Val Gly Arg Leu Leu Asp Glu 
                165                 170                 175     


Ile Glu Arg Gly Asp Gly Pro Val Ala Val Arg Arg Ala Ile Asp Arg 
            180                 185                 190         


Phe Ser Lys Gly Arg Gly Leu Gly Ala Val Glu Val Val His Leu Val 
        195                 200                 205             


His His Leu Ser Glu Trp Glu Pro Asp Ser Gln Glu Leu Arg Glu Trp 
    210                 215                 220                 


Leu Ala Ala His Val Ala Asn Ser Ser Glu Ser Ile Glu Arg Leu Thr 
225                 230                 235                 240 


Thr Tyr Glu Ala Glu Trp His Ala Glu Ile Gln Val Leu Ile Gly Asn 
                245                 250                 255     


Leu Val Gln Ser Leu His Ala Leu Glu Arg Met Ser Trp Gln Pro Ile 
            260                 265                 270         


Ala Ser Arg Ile Ser Arg Val Glu Ser Cys Leu Arg Gln Glu Pro Thr 
        275                 280                 285             


Gly Asp Tyr Leu Arg Leu Asp Pro Thr Ser Gln Asn Val Leu Thr Gln 
    290                 295                 300                 


Gln Val Ser Trp Leu Ser Glu Ala Phe Arg Leu Pro Glu Ala Met Ile 
305                 310                 315                 320 


Ala Glu Thr Ala Val Ser Leu Ala Arg Glu Ala Trp Glu Lys Ala Gly 
                325                 330                 335     


Ser Pro Thr Ala Ser Ser Asp Leu Pro Arg Glu Ala Phe Val Ala Tyr 
            340                 345                 350         


Tyr Leu Cys Asp Pro Asp Gly Met His Ala Leu His Arg Ser Leu Lys 
        355                 360                 365             


Glu Arg Ala Lys Pro Arg Ser Val Pro Gln Ile Ala Leu Arg Arg Arg 
    370                 375                 380                 


Pro Leu Arg Ser Tyr Leu Leu Gly Val Ala Phe Leu Phe Ala Ala Ile 
385                 390                 395                 400 


Leu Trp Ala Val Leu Gly Gly Phe Thr Gly Gly Phe Arg Ala Pro Leu 
                405                 410                 415     


Gly Ala Thr Leu Ala Leu Ala Val Leu Leu Ala Leu Pro Val Ser Glu 
            420                 425                 430         


Trp Val Ile Ser Leu Val His Glu Gly Ile Arg Arg Ala Val Arg Pro 
        435                 440                 445             


Val Pro Leu Leu Arg Leu Asp Phe Ser Glu Gly Ile Pro Glu Asp Ala 
    450                 455                 460                 


Arg Thr Leu Ile Val Leu Pro Val Ile Trp Ala Ser Glu Ala Asp Val 
465                 470                 475                 480 


Asp Glu Ala Phe Asp Lys Ile Glu Leu His His Leu Thr Asn Arg Gly 
                485                 490                 495     


Ala His Leu Tyr Phe Ala Val Leu Ser Asp Leu Arg Asp Ala Asp Ala 
            500                 505                 510         


Pro His Leu Pro Glu Asp Glu Pro Leu Leu Ala Arg Ala Arg Ala Arg 
        515                 520                 525             


Leu Glu Ala Leu Arg His Lys Tyr Gly Ala Ala Arg Phe Phe Trp Phe 
    530                 535                 540                 


His Arg Asp Arg Val Leu Asn Arg Ala Asp Gly Val Tyr Met Gly Trp 
545                 550                 555                 560 


Glu Arg Lys Arg Gly Lys Leu Val Glu Phe Val Glu Leu Leu Arg Gly 
                565                 570                 575     


Lys Arg Asp Thr Thr Phe Arg Val Lys Asp Gly Asp Leu Ala Val Leu 
            580                 585                 590         


Pro Thr Ile Arg Tyr Val Phe Thr Ala Asp Leu Asp Thr Glu Leu Pro 
        595                 600                 605             


Ile Gly Thr Val Gln Arg Leu Val Gly Thr Met His Leu Pro Tyr Asn 
    610                 615                 620                 


Arg Pro Arg Leu Asn Ala Arg Gly Thr Arg Val Asp Gln Gly Tyr Gly 
625                 630                 635                 640 


Val Leu Gln Pro Ala Val Ala Val Ser Pro Arg Ser Thr Gln Ala Ser 
                645                 650                 655     


Arg Phe Ala Arg Leu Trp Ser Gly Glu Thr Gly Val Asp Pro Tyr Ala 
            660                 665                 670         


Phe Ala Ile Ser Asn Pro Tyr Gln Asp Trp Phe Gly Arg Gly Leu Phe 
        675                 680                 685             


Val Gly Lys Gly Leu Ile His Val Asp Ala Phe His Thr Val Leu Cys 
    690                 695                 700                 


Asp Arg Ile Pro Asp Asn Arg Val Leu Ser His Asp Ile Leu Glu Gly 
705                 710                 715                 720 


Gly Phe Leu Arg Ala Gly Leu Val Ala Asp Val Glu Val Val Glu Ser 
                725                 730                 735     


Gln Pro Ala Thr Leu Arg Ala Tyr Met Arg Arg Ala His Arg Trp Val 
            740                 745                 750         


Arg Gly Asp Trp Gln Leu Thr Tyr Trp Leu Arg Arg Val Cys Arg Asp 
        755                 760                 765             


Arg Arg Gly Glu Thr Gln Pro Val Asp Leu Cys Gly Phe Thr Arg Trp 
    770                 775                 780                 


Asn Ile Val Asp His Val Arg His Ser Leu Val Asn Pro Ala Leu Val 
785                 790                 795                 800 


Leu Leu Met Gly Ser Gly Met Ser Gly Leu Leu Pro Gly Pro Ala Tyr 
                805                 810                 815     


Ala Tyr Gly Ala Val Leu Leu Ile Thr Val Phe Leu Pro Phe Leu Arg 
            820                 825                 830         


Gln Leu Glu Ser Ile Arg Pro Gly Glu Trp Asp Trp Arg Ser Ala Ala 
        835                 840                 845             


Thr Ala Leu Gly Gln Ser Leu Val Met Leu Val Thr Leu Pro Phe Met 
    850                 855                 860                 


Ala Val Val Glu Ala Asp Ala Ser Leu Arg Ala Leu Tyr Arg Met Leu 
865                 870                 875                 880 


Val Ser Arg Arg Arg Leu Leu Glu Trp Ile Pro Ser Ser His Ala Asp 
                885                 890                 895     


Arg Ser Asp Gly Ser Pro Ala Pro Leu Leu Tyr Glu Pro Ala Gly Tyr 
            900                 905                 910         


Ala Val Ala Leu Ala Cys Ser Val Pro Gly Leu Phe Gly Thr Trp Glu 
        915                 920                 925             


Gln Ala Leu Ser Ser Thr Leu Ala Leu Ala Val Trp Leu Pro Ala His 
    930                 935                 940                 


Ala Val Ala Arg Phe Leu Ala Lys Pro Ala Gly Glu Ala Arg Val Ala 
945                 950                 955                 960 


Ala Pro Asp Pro Ala Leu Ser Ala His Leu Arg Glu Val Ala Thr Ala 
                965                 970                 975     


Met Trp Arg Phe Tyr Glu Arg Tyr Val Gly Glu Glu Asp His His Leu 
            980                 985                 990         


Pro Pro Asp Asn Val Gln Phe Glu  Pro Val Glu Arg Ile  Ala His Arg 
        995                 1000                 1005             


Thr Ser  Pro Thr Asn Ile Gly  Leu Tyr Leu Leu Cys  Val Ala Ala 
    1010                 1015                 1020             


Ala Ala  Asp Leu Glu Ile Ile  Pro Lys Glu Gly Ala  Ile Ala Arg 
    1025                 1030                 1035             


Leu Glu  Arg Thr Leu Ala Thr  Leu Thr Ser Leu Asp  Arg Trp His 
    1040                 1045                 1050             


Gly His  Leu Phe Asn Trp Tyr  Asp Thr Arg Thr Leu  Arg Pro Leu 
    1055                 1060                 1065             


Ala Pro  Arg Tyr Val Ser Thr  Val Asp Ser Gly Asn  Leu Val Cys 
    1070                 1075                 1080             


Ala Met  Leu Ala Leu Gly Gln  Ala Leu Arg Glu Trp  Ala Ala Ser 
    1085                 1090                 1095             


Asp Ala  Asp Ile Ala Pro Arg  Ala Arg Arg Leu Ala  Asp Ala Met 
    1100                 1105                 1110             


Glu Gly  Phe Ala Arg Glu Ile  Asp Phe Arg Pro Leu  Tyr Arg Pro 
    1115                 1120                 1125             


Asp Leu  Arg Leu Phe Ser Leu  Gly Phe His Ala Asp  Arg Asn Glu 
    1130                 1135                 1140             


Leu Glu  Asn Ile Val Tyr Asp  Leu Leu Ala Ser Glu  Ala Arg Gln 
    1145                 1150                 1155             


Ala Ser  Phe Ile Ala Ile Ala  Ser Gly Gln Val Pro  Ala Ser His 
    1160                 1165                 1170             


Trp Phe  Ala Leu Ser Arg Thr  Met Thr Arg Ala Gly  Arg Tyr Gln 
    1175                 1180                 1185             


Pro Leu  Leu Ser Trp Ser Gly  Thr Met Phe Glu Tyr  Leu Met Pro 
    1190                 1195                 1200             


Ala Leu  Leu Met Arg His Leu  Pro His Thr Leu Trp  Glu Glu Thr 
    1205                 1210                 1215             


Tyr Arg  Gly Val Val Trp Arg  Gln Ile Ala Tyr Ala  Arg Glu Arg 
    1220                 1225                 1230             


Gly Val  Pro Phe Gly Ile Ser  Glu Ser Gly Phe Tyr  Ala Phe Asp 
    1235                 1240                 1245             


Arg Asp  Leu Asn Tyr Gln Tyr  Arg Ala Phe Gly Val  Pro Gly Leu 
    1250                 1255                 1260             


Gly Leu  Asp Arg Gly Leu Glu  Gln His Leu Val Val  Ala Pro Tyr 
    1265                 1270                 1275             


Ala Thr  Met Leu Ala Leu Pro  Phe Ala Pro Glu Gln  Val Ala Glu 
    1280                 1285                 1290             


Ala Leu  Arg Gln Leu Arg Glu  Leu Gly Ala Leu Gly  Pro Tyr Gly 
    1295                 1300                 1305             


Tyr Tyr  Glu Ala Val Asp Phe  Thr Ala Ser Arg Leu  Pro Pro Gly 
    1310                 1315                 1320             


Asp Arg  Tyr Lys Val Val Gln  Ser Phe Met Ala His  His Gln Gly 
    1325                 1330                 1335             


Met Ala  Phe Ile Ala Ile Ala  Asn Tyr Leu Asn Arg  Asn Leu Trp 
    1340                 1345                 1350             


Val Glu  Arg Phe His Arg Leu  Pro Leu Val Arg Ala  Ala Glu Tyr 
    1355                 1360                 1365             


Met Leu  Tyr Glu Arg Met Pro  Lys Arg Pro Ala Leu  Leu Leu Lys 
    1370                 1375                 1380             


Pro Val  His Ala Ala His Ala  Pro Asn Phe Asp Arg  Pro Val Tyr 
    1385                 1390                 1395             


Ala Arg  Arg Arg Ser Gly Asp  Asp Val Ala Trp Asn  Ala Val Ser 
    1400                 1405                 1410             


Asn Gly  Ser Leu Thr Ser Phe  Ala Asp Ala Arg Gly  Glu Gly Gly 
    1415                 1420                 1425             


Ile Ala  Trp Arg Gly Ile Ala  Val Thr Arg Tyr Arg  Pro Asp Arg 
    1430                 1435                 1440             


His Leu  Pro Tyr Arg Gly Pro  Val Met Tyr Val Arg  Asp Val Asp 
    1445                 1450                 1455             


Arg Gly  Gly Val Phe Arg Thr  Thr Leu His Gly Gly  Gly Gly His 
    1460                 1465                 1470             


Val Glu  Ala Glu Phe Arg Pro  Asp Lys Ser Ser Trp  Lys Arg Val 
    1475                 1480                 1485             


Val Asp  Gly Ile Glu Ser Glu  Trp Ser Val Leu Val  Ala Pro Asp 
    1490                 1495                 1500             


Arg Asp  Val Glu Ile Arg Thr  Leu Val Leu Gln Asn  Leu Gly Glu 
    1505                 1510                 1515             


Asp Val  Arg Arg Leu Glu Val  Thr Tyr Phe Ala Glu  Leu Ala Leu 
    1520                 1525                 1530             


Ala Lys  Pro Ala Ala Asp Ile  Ala His Pro Ser Phe  Gln Arg Leu 
    1535                 1540                 1545             


Phe Val  Glu Thr Gly Trp Asp  Asp Ala Arg Gln Val  Leu Trp Ala 
    1550                 1555                 1560             


Gln Arg  Arg Pro Glu Ser Asp  Asp Gln Pro Asp Val  Tyr Ala Ala 
    1565                 1570                 1575             


Phe His  Leu Val Ala Asp Glu  Glu Ala Pro Ala Pro  Val Glu Trp 
    1580                 1585                 1590             


Asp Ser  His Arg Ala Arg Phe  Val Gly Arg Gly Gly  Ser Leu Ala 
    1595                 1600                 1605             


Ala Pro  Arg Gly Leu Trp Arg  Arg Leu Arg Gly Glu  Gly Val Ala 
    1610                 1615                 1620             


Asp Pro  Ala Ala Ile Leu Arg  Thr Ala Val Thr Leu  Ala Pro Gly 
    1625                 1630                 1635             


Glu Lys  Arg Ala Leu Tyr Val  Ile Thr Ala Leu Gly  Glu Ala Arg 
    1640                 1645                 1650             


Asp Glu  Val Val Glu Thr Ala  Phe Glu Met Arg Gln  Pro Ser Ala 
    1655                 1660                 1665             


Arg Ser  Arg Ala Ala Gln Leu  Ala Trp Met Arg Ala  Gln Ile Asp 
    1670                 1675                 1680             


Leu Arg  Gln Leu His Leu Ser  Pro Asp Asp Val Glu  Asp Ala Met 
    1685                 1690                 1695             


Glu Leu  Leu Ser Arg Phe Leu  Ser Arg His Ala Phe  Ser Pro Glu 
    1700                 1705                 1710             


Arg Arg  Ala Ala Ile Leu Gln  Asn Glu Leu Gly Gln  Ser Gly Leu 
    1715                 1720                 1725             


Trp Ala  His Gly Ile Ser Gly  Asp Arg Pro Ile Val  Ala Val Arg 
    1730                 1735                 1740             


Leu Ala  Ser Ala Ala Glu Val  Pro Phe Val Ala Lys  Leu Ala Arg 
    1745                 1750                 1755             


Leu Thr  Gln Tyr Leu Ala His  Met Gly Phe Ala Ser  Asp Leu Val 
    1760                 1765                 1770             


Val Ile  Asp Glu Thr Ile Ser  Ser Tyr Arg Asp Glu  Met Arg Asp 
    1775                 1780                 1785             


Arg Ile  Arg Ala Glu Met Ala  Arg Arg Gly Val His  Asp Ala Ala 
    1790                 1795                 1800             


Thr Leu  Ala Val Val Lys Ala  Asp Gln Leu Ser Ser  Ala Glu Arg 
    1805                 1810                 1815             


Ala Leu  Met Glu Ser Val Ala  Val Ala Thr Leu Arg  Ala Gly Gly 
    1820                 1825                 1830             


Pro Ser  Val Gly Ala Gln Leu  Thr Gly Gly Arg Val  Arg Arg Glu 
    1835                 1840                 1845             


Glu Ser  Ala Arg Leu Ala Ser  Asp Arg Leu Glu Pro  Glu Pro Lys 
    1850                 1855                 1860             


Arg Ala  Pro Arg Asp Ala Gly  Gln Val Glu Gly Glu  Phe Ala Asn 
    1865                 1870                 1875             


Gly Tyr  Gly Ala Phe Val Asp  Asp Gly Arg Ala Tyr  Arg Met Arg 
    1880                 1885                 1890             


Val Thr  Arg Ala Lys Arg Pro  Pro Arg Pro Trp Ser  Asn Val Leu 
    1895                 1900                 1905             


Ala Asn  Pro Asn Phe Gly Ala  Leu Val Thr Glu Leu  Gly Thr Gly 
    1910                 1915                 1920             


Tyr Thr  Trp Trp Arg Asn Ser  Arg Glu Phe Lys Leu  Thr Pro Trp 
    1925                 1930                 1935             


His Asn  Asp Ala Ala Phe Asp  Pro Pro Gly Glu Ala  Val Tyr Ile 
    1940                 1945                 1950             


Ala Asp  Leu Asp Arg Gly Ile  Ile Ala Ser Ala Thr  Pro Ser Pro 
    1955                 1960                 1965             


Ala Gly  Asp Glu Arg Thr Tyr  Asp Val Thr His Arg  Pro Gly Val 
    1970                 1975                 1980             


Thr Thr  Phe Glu Ser Asp Val  Glu Gly Val Arg Val  Thr Leu His 
    1985                 1990                 1995             


Val Phe  Val Asp Ser Ala Glu  Pro Ala Lys Trp Met  Arg Val Arg 
    2000                 2005                 2010             


Leu Arg  Asn Gln Ser Gly Glu  Glu Arg Arg Ile Arg  Val Ala Pro 
    2015                 2020                 2025             


Tyr Ala  Glu Trp Val Leu Gly  Val Asp Pro Phe Ser  Asn Thr Pro 
    2030                 2035                 2040             


Leu Val  Val Val Arg Lys Met  Gly Glu Ala Asp Ala  Ile Ala Ala 
    2045                 2050                 2055             


Glu Asn  Arg Tyr Gln Glu Ala  Phe Arg Gly Ala Leu  Gly Phe Leu 
    2060                 2065                 2070             


Ala Val  Gly Gly Ala Gly Arg  Thr Thr Gly Trp Leu  Gly Asp Lys 
    2075                 2080                 2085             


Thr Arg  Phe Leu Gly Asp Gly  Ser Tyr Ala Arg Pro  Asp Ala Leu 
    2090                 2095                 2100             


Leu Glu  Asp Ala Trp Arg Gly  Gly Asp Gly Pro Thr  Pro Thr Pro 
    2105                 2110                 2115             


Cys Ala  Val Leu Ala Arg Asp  Leu Asp Leu Gly Pro  His Glu Glu 
    2120                 2125                 2130             


Ala Glu  Val Val Ile Leu Leu  Gly Ala Ala Pro Asp  Glu His Glu 
    2135                 2140                 2145             


Ala Ala  Arg Leu Ala Arg Leu  Ala Asp Pro Ala Ala  Ala Asp Arg 
    2150                 2155                 2160             


Ala Leu  Arg Glu Val Thr Arg  Phe Trp Asp Asp Leu  Leu Gly Arg 
    2165                 2170                 2175             


Val Gln  Ile Arg Thr Pro Asp  Arg Ala Phe Asp Ile  Leu Met Asn 
    2180                 2185                 2190             


Gly Trp  Leu Val Tyr Gln Ala  Leu Ala Cys Arg Leu  Trp Ala Arg 
    2195                 2200                 2205             


Thr Ala  Phe Tyr Gln Ala Gly  Gly Ala Phe Gly Phe  Arg Asp Gln 
    2210                 2215                 2220             


Leu Gln  Asp Ala Leu Ala Leu  Ile His Ala Arg Pro  Asp Ile Leu 
    2225                 2230                 2235             


Arg Asp  Gln Ile Leu Arg Ala  Ala Arg His Gln Tyr  Val Glu Gly 
    2240                 2245                 2250             


Asp Val  Gln His Trp Trp His  Glu Glu Leu Gly Lys  Gly Ile Arg 
    2255                 2260                 2265             


Thr Arg  Phe Ser Asp Asp Leu  Leu Trp Leu Pro Tyr  Ala Val Ser 
    2270                 2275                 2280             


Arg Tyr  Leu Glu Ala Thr Gly  Asp Ala Ala Leu Leu  Asp Glu Arg 
    2285                 2290                 2295             


Ala Pro  Tyr Leu Val Ser Ala  Pro Leu Gly Asp Gly  Glu Leu Glu 
    2300                 2305                 2310             


Arg Tyr  Glu Asp Ser Val Trp  Ser Gln Glu Glu Gly  Thr Leu Ala 
    2315                 2320                 2325             


Glu His  Val Ala Arg Ala Val  Glu Arg Ala Leu His  Phe Gly Asp 
    2330                 2335                 2340             


His Gly  Leu Pro Leu Ile Gly  Ile Gly Asp Trp Asn  Asp Gly Leu 
    2345                 2350                 2355             


Ser Arg  Val Gly Ala Lys Gly  Arg Gly Glu Ser Val  Trp Leu Ala 
    2360                 2365                 2370             


Trp Phe  Leu Ala Asp Val Val  Arg Arg Val Ala Glu  Ile Asp His 
    2375                 2380                 2385             


Pro Glu  Phe Ala Gln His Arg  Ala Arg Trp Leu Ala  Met Arg Glu 
    2390                 2395                 2400             


Arg Val  Leu Ala Ala Ala Asn  Glu Ser Ala Trp Asp  Gly Gln Trp 
    2405                 2410                 2415             


Tyr Arg  Arg Ala Ile Thr Asp  Asp Gly Leu Trp Leu  Gly Ser Ala 
    2420                 2425                 2430             


Ala Ser  Pro Ala Cys Arg Val  Asp Ala Ile Ala Gln  Ser Trp Ala 
    2435                 2440                 2445             


Val Ile  Ser Gly Gly Ala Pro  Pro Asp Arg Ala Val  Arg Ala Met 
    2450                 2455                 2460             


Glu Ser  Phe Asp Arg Glu Leu  Val Asp Arg Arg Leu  Gly Val Ala 
    2465                 2470                 2475             


His Leu  Leu Gln Pro Ala Phe  Arg Asp Leu Arg Pro  Ser Pro Gly 
    2480                 2485                 2490             


Tyr Ile  Gln Gly Tyr Pro Pro  Gly Ile Arg Glu Asn  Gly Gly Gln 
    2495                 2500                 2505             


Tyr Thr  His Gly Val Ile Trp  Ser Val Ile Ala Trp  Thr Arg Leu 
    2510                 2515                 2520             


Gly Arg  Ala Asp Glu Ala Tyr  Glu Leu Phe Ser Met  Leu Asn Pro 
    2525                 2530                 2535             


Ile His  His Ala Asp Thr Pro  Arg Glu Val Glu Arg  Tyr Gly Asn 
    2540                 2545                 2550             


Glu Pro  Tyr Val Met Ser Ala  Asp Val Tyr Thr Ala  Glu Pro Asn 
    2555                 2560                 2565             


Val Gly  Gln Gly Gly Trp Ser  Trp Tyr Thr Gly Ala  Ala Ser Trp 
    2570                 2575                 2580             


Met Tyr  Gln Ala Gly Leu Glu  Ala Ile Leu Gly Ile  Arg Arg His 
    2585                 2590                 2595             


Gly Thr  Arg Leu Leu Val Glu  Pro Cys Val Pro Ala  His Trp Pro 
    2600                 2605                 2610             


Gly Phe  Glu Val Ala Tyr Arg  Tyr Gly Ser Thr Leu  Tyr Arg Ile 
    2615                 2620                 2625             


Arg Val  Glu Arg Ala Pro Gln  Gly Ala Glu Ala Arg  Asp Ser Ala 
    2630                 2635                 2640             


Leu Thr  Val Glu Gly Val Ala  Pro Ala Glu Ile Asp  Leu Val Asp 
    2645                 2650                 2655             


Asp Gly  Gln Glu His His Val  Val Val Trp Leu Ala  Ala Glu Gly 
    2660                 2665                 2670             


Ala Glu  Val Leu Ser Asp Val  Gln Thr Val Ala Ala  Arg Pro Arg 
    2675                 2680                 2685             


Glu Gly  Ala Arg Arg Tyr Arg  Met Ser Ser Gly Ala  Arg Ala Phe 
    2690                 2695                 2700             


Pro Ala  Ser Ala Ala Tyr Arg  Lys Arg Asp Pro Gln  Pro 
    2705                 2710                 2715     


<210>  214
<211>  2716
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:202 and encoded by SEQ ID NO:209

<400>  214

Met Ala Phe Asp Thr Glu Val Glu Arg Arg Ala His Ala Leu Ala Leu 
1               5                   10                  15      


Thr Gln Asp Ile Ser Ser Thr Arg Gly Gly Gly Ser Asp Leu Trp Pro 
            20                  25                  30          


Ile Leu Arg Arg Lys Ala Ala Arg Val Arg Asn Leu Ala Thr Arg Leu 
        35                  40                  45              


Glu Arg Glu Pro Ala Ala Cys Ser Glu Pro Ala His Glu Trp Leu Ile 
    50                  55                  60                  


Asp His Ala Ala Tyr Leu Glu Leu Gln Ala Met Leu Ala Glu Arg Leu 
65                  70                  75                  80  


Trp Pro Asn Ala Val Val Arg Lys Leu Pro Arg Met Ala Glu Thr Gly 
                85                  90                  95      


Glu Pro Arg Val Val Thr Leu Ala Ala Ala Tyr Leu Asp Ala Thr Arg 
            100                 105                 110         


Gly His Val Glu Ala Glu Thr Leu Ile Arg Phe Val Glu Ala Tyr Gln 
        115                 120                 125             


Asp Val Gln Val Leu Thr Thr His Glu Cys His Gln Leu Ala Asn Gly 
    130                 135                 140                 


Leu Arg Val Ala Ile Leu Thr Arg Leu Ala Glu Ala Ser Asp Glu Ile 
145                 150                 155                 160 


Gln His Arg Tyr Glu Thr Cys Arg Ala Val Gly Arg Leu Leu Asp Glu 
                165                 170                 175     


Ile Glu Arg Gly Asp Gly Pro Val Ala Val Arg Arg Ala Ile Asp Arg 
            180                 185                 190         


Phe Ser Lys Gly Arg Gly Leu Gly Ala Val Glu Val Val His Leu Val 
        195                 200                 205             


His His Leu Ser Glu Trp Glu Pro Asp Ser Gln Glu Leu Arg Glu Trp 
    210                 215                 220                 


Leu Ala Ala His Val Ala Asn Ser Ser Glu Ser Ile Glu Arg Leu Thr 
225                 230                 235                 240 


Thr Tyr Glu Ala Glu Trp His Ala Glu Ile Gln Val Leu Ile Gly Asn 
                245                 250                 255     


Leu Val Gln Ser Leu His Ala Leu Glu Arg Met Ser Trp Gln Pro Ile 
            260                 265                 270         


Ala Ser Arg Ile Ser Arg Val Glu Ser Cys Leu Arg Gln Glu Pro Thr 
        275                 280                 285             


Gly Asp Tyr Leu Arg Leu Asp Pro Thr Ser Gln Asn Val Leu Thr Gln 
    290                 295                 300                 


Gln Val Ser Trp Leu Ser Glu Ala Phe Arg Leu Pro Glu Ala Met Ile 
305                 310                 315                 320 


Ala Glu Thr Ala Val Ser Leu Ala Arg Glu Ala Trp Glu Lys Ala Gly 
                325                 330                 335     


Ser Pro Thr Ala Ser Ser Asp Leu Pro Arg Glu Ala Phe Val Ala Tyr 
            340                 345                 350         


Tyr Leu Cys Asp Pro Asp Gly Met His Ala Leu His Arg Ser Leu Lys 
        355                 360                 365             


Glu Arg Ala Lys Pro Arg Ser Val Pro Gln Ile Ala Leu Arg Arg Arg 
    370                 375                 380                 


Pro Leu Arg Ser Tyr Leu Leu Gly Val Ala Phe Leu Phe Ala Ala Ile 
385                 390                 395                 400 


Leu Trp Ala Val Leu Gly Gly Phe Thr Gly Gly Phe Arg Ala Pro Leu 
                405                 410                 415     


Gly Ala Thr Leu Ala Leu Ala Val Leu Leu Ala Leu Pro Val Ser Glu 
            420                 425                 430         


Trp Val Ile Ser Leu Val His Glu Gly Ile Arg Arg Ala Val Arg Pro 
        435                 440                 445             


Val Pro Leu Leu Arg Leu Asp Phe Ser Glu Gly Ile Pro Glu Asp Ala 
    450                 455                 460                 


Arg Thr Leu Ile Val Leu Pro Val Ile Trp Ala Ser Glu Ala Asp Val 
465                 470                 475                 480 


Asp Glu Ala Phe Asp Lys Ile Glu Leu His His Leu Thr Asn Arg Gly 
                485                 490                 495     


Ala His Leu Tyr Phe Ala Val Leu Ser Asp Leu Arg Asp Ala Asp Ala 
            500                 505                 510         


Pro His Leu Pro Glu Asp Glu Pro Leu Leu Ala Arg Ala Arg Ala Arg 
        515                 520                 525             


Leu Glu Ala Leu Arg His Lys Tyr Gly Ala Ala Arg Phe Phe Trp Phe 
    530                 535                 540                 


His Arg Asp Arg Val Leu Asn Arg Ala Asp Gly Val Tyr Met Gly Trp 
545                 550                 555                 560 


Glu Arg Lys Arg Gly Lys Leu Val Glu Phe Val Glu Leu Leu Arg Gly 
                565                 570                 575     


Lys Arg Asp Thr Thr Phe Arg Val Lys Asp Gly Asp Leu Ala Val Leu 
            580                 585                 590         


Pro Thr Ile Arg Tyr Val Phe Thr Ala Asp Leu Asp Thr Glu Leu Pro 
        595                 600                 605             


Ile Gly Thr Val Gln Arg Leu Val Gly Thr Met His Leu Pro Tyr Asn 
    610                 615                 620                 


Arg Pro Arg Leu Asn Ala Arg Gly Thr Arg Val Asp Gln Gly Tyr Gly 
625                 630                 635                 640 


Val Leu Gln Pro Ala Val Ala Val Ser Pro Arg Ser Thr Gln Ala Ser 
                645                 650                 655     


Arg Phe Ala Arg Leu Trp Ser Gly Glu Thr Gly Val Asp Pro Tyr Ala 
            660                 665                 670         


Phe Ala Ile Ser Asn Pro Tyr Gln Asp Trp Phe Gly Arg Gly Leu Phe 
        675                 680                 685             


Val Gly Lys Gly Leu Ile His Val Asp Ala Phe His Thr Val Leu Cys 
    690                 695                 700                 


Asp Arg Ile Pro Asp Asn Arg Val Leu Ser His Asp Ile Leu Glu Gly 
705                 710                 715                 720 


Gly Phe Leu Arg Ala Gly Leu Val Ala Asp Val Glu Val Val Glu Ser 
                725                 730                 735     


Gln Pro Ala Thr Leu Arg Ala Tyr Met Arg Arg Ala His Arg Trp Val 
            740                 745                 750         


Arg Gly Asp Trp Gln Leu Thr Tyr Trp Leu Arg Arg Val Cys Arg Asp 
        755                 760                 765             


Arg Arg Gly Glu Thr Gln Pro Val Asp Leu Cys Gly Phe Thr Arg Trp 
    770                 775                 780                 


Asn Ile Val Asp His Val Arg His Ser Leu Val Asn Pro Ala Leu Val 
785                 790                 795                 800 


Leu Leu Met Gly Ser Gly Met Ser Gly Leu Leu Pro Gly Pro Ala Tyr 
                805                 810                 815     


Ala Tyr Gly Ala Val Leu Leu Ile Thr Val Phe Leu Pro Phe Leu Arg 
            820                 825                 830         


Gln Leu Glu Ser Ile Arg Pro Gly Glu Trp Asp Trp Arg Ser Ala Ala 
        835                 840                 845             


Thr Ala Leu Gly Gln Ser Leu Val Met Leu Val Thr Leu Pro Phe Met 
    850                 855                 860                 


Ala Val Val Glu Ala Asp Ala Ser Leu Arg Ala Leu Tyr Arg Met Leu 
865                 870                 875                 880 


Val Ser Arg Arg Arg Leu Leu Glu Trp Ile Pro Ser Ser His Ala Asp 
                885                 890                 895     


Arg Ser Asp Gly Ser Pro Ala Pro Leu Leu Tyr Glu Pro Ala Gly Tyr 
            900                 905                 910         


Ala Val Ala Leu Ala Cys Ser Val Pro Gly Leu Phe Gly Thr Trp Glu 
        915                 920                 925             


Gln Ala Leu Ser Ser Thr Leu Ala Leu Ala Val Trp Leu Pro Ala His 
    930                 935                 940                 


Ala Val Ala Arg Phe Leu Ala Lys Pro Ala Gly Glu Ala Arg Val Ala 
945                 950                 955                 960 


Ala Pro Asp Pro Ala Leu Ser Ala His Leu Arg Glu Val Ala Thr Ala 
                965                 970                 975     


Met Trp Arg Phe Tyr Glu Arg Tyr Val Gly Glu Glu Asp His His Leu 
            980                 985                 990         


Pro Pro Asp Asn Val Gln Phe Glu  Pro Val Glu Arg Ile  Ala His Arg 
        995                 1000                 1005             


Thr Ser  Pro Thr Asn Ile Gly  Leu Tyr Leu Leu Cys  Val Ala Ala 
    1010                 1015                 1020             


Ala Ala  Asp Leu Glu Ile Ile  Pro Lys Glu Gly Ala  Ile Ala Arg 
    1025                 1030                 1035             


Leu Glu  Arg Thr Leu Ala Thr  Leu Thr Ser Leu Asp  Arg Trp His 
    1040                 1045                 1050             


Gly His  Leu Phe Asn Trp Tyr  Asp Thr Arg Thr Leu  Arg Pro Leu 
    1055                 1060                 1065             


Ala Pro  Arg Tyr Val Ser Thr  Val Asp Ser Gly Asn  Leu Val Cys 
    1070                 1075                 1080             


Ala Met  Leu Ala Leu Gly Gln  Ala Leu Arg Glu Trp  Ala Ala Ser 
    1085                 1090                 1095             


Asp Ala  Asp Ile Ala Pro Arg  Ala Arg Arg Leu Ala  Asp Ala Met 
    1100                 1105                 1110             


Glu Gly  Phe Ala Arg Glu Ile  Asp Phe Arg Pro Leu  Tyr Arg Pro 
    1115                 1120                 1125             


Asp Leu  Arg Leu Phe Ser Leu  Gly Phe His Ala Asp  Arg Asn Glu 
    1130                 1135                 1140             


Leu Glu  Asn Ile Val Tyr Asp  Leu Leu Ala Ser Glu  Ala Arg Gln 
    1145                 1150                 1155             


Ala Ser  Phe Ile Ala Ile Ala  Ser Gly Gln Val Pro  Ala Ser His 
    1160                 1165                 1170             


Trp Phe  Ala Leu Ser Arg Thr  Met Thr Arg Ala Gly  Arg Tyr Gln 
    1175                 1180                 1185             


Pro Leu  Leu Ser Trp Ser Gly  Thr Met Phe Glu Tyr  Leu Met Pro 
    1190                 1195                 1200             


Ala Leu  Leu Met Arg His Leu  Pro His Thr Leu Trp  Glu Glu Thr 
    1205                 1210                 1215             


Tyr Arg  Gly Val Val Trp Arg  Gln Ile Ala Tyr Ala  Arg Glu Arg 
    1220                 1225                 1230             


Gly Val  Pro Phe Gly Ile Ser  Glu Ser Gly Phe Tyr  Ala Phe Asp 
    1235                 1240                 1245             


Arg Asp  Leu Asn Tyr Gln Tyr  Arg Ala Phe Gly Val  Pro Gly Leu 
    1250                 1255                 1260             


Gly Leu  Asp Arg Gly Leu Glu  Gln His Leu Val Val  Ala Pro Tyr 
    1265                 1270                 1275             


Ala Thr  Met Leu Ala Leu Pro  Phe Ala Pro Glu Gln  Val Ala Glu 
    1280                 1285                 1290             


Ala Leu  Arg Gln Leu Arg Glu  Leu Gly Ala Leu Gly  Pro Tyr Gly 
    1295                 1300                 1305             


Tyr Tyr  Glu Ala Val Asp Phe  Thr Ala Ser Arg Leu  Pro Pro Gly 
    1310                 1315                 1320             


Asp Arg  Tyr Lys Val Val Gln  Ser Phe Met Ala His  His Gln Gly 
    1325                 1330                 1335             


Met Ala  Phe Ile Ala Ile Ala  Asn Tyr Leu Asn Arg  Asn Leu Trp 
    1340                 1345                 1350             


Val Glu  Arg Phe His Arg Leu  Pro Leu Val Arg Ala  Ala Glu Tyr 
    1355                 1360                 1365             


Met Leu  Tyr Glu Arg Met Pro  Lys Arg Pro Ala Leu  Leu Leu Lys 
    1370                 1375                 1380             


Pro Val  His Ala Ala His Ala  Pro Asn Phe Asp Arg  Pro Val Tyr 
    1385                 1390                 1395             


Ala Arg  Arg Arg Ser Gly Asp  Asp Val Ala Trp Asn  Ala Val Ser 
    1400                 1405                 1410             


Asn Gly  Ser Leu Thr Ser Phe  Ala Asp Ala Arg Gly  Glu Gly Gly 
    1415                 1420                 1425             


Ile Ala  Trp Arg Gly Ile Ala  Val Thr Arg Tyr Arg  Pro Asp Arg 
    1430                 1435                 1440             


His Leu  Pro Tyr Arg Gly Pro  Val Met Tyr Val Arg  Asp Val Asp 
    1445                 1450                 1455             


Arg Gly  Gly Val Phe Arg Thr  Thr Leu His Gly Gly  Gly Gly His 
    1460                 1465                 1470             


Val Glu  Ala Glu Phe Arg Pro  Asp Lys Ser Ser Trp  Lys Arg Val 
    1475                 1480                 1485             


Val Asp  Gly Ile Glu Ser Glu  Trp Ser Val Leu Val  Ala Pro Asp 
    1490                 1495                 1500             


Arg Asp  Val Glu Ile Arg Thr  Leu Val Leu Gln Asn  Leu Gly Glu 
    1505                 1510                 1515             


Asp Val  Arg Arg Leu Glu Val  Thr Tyr Phe Ala Glu  Leu Ala Leu 
    1520                 1525                 1530             


Ala Lys  Pro Ala Ala Asp Ile  Ala His Pro Ser Phe  Gln Arg Leu 
    1535                 1540                 1545             


Phe Val  Glu Thr Gly Trp Asp  Asp Ala Arg Gln Val  Leu Trp Ala 
    1550                 1555                 1560             


Gln Arg  Arg Pro Glu Ser Asp  Asp Gln Pro Asp Val  Tyr Ala Ala 
    1565                 1570                 1575             


Phe His  Leu Val Ala Asp Glu  Glu Ala Pro Ala Pro  Val Glu Trp 
    1580                 1585                 1590             


Asp Ser  His Arg Ala Arg Phe  Val Gly Arg Gly Gly  Ser Leu Ala 
    1595                 1600                 1605             


Ala Pro  Arg Gly Leu Trp Arg  Arg Leu Arg Gly Glu  Gly Val Ala 
    1610                 1615                 1620             


Asp Pro  Ala Ala Ile Leu Arg  Thr Ala Val Thr Leu  Ala Pro Gly 
    1625                 1630                 1635             


Glu Lys  Arg Ala Leu Tyr Val  Ile Thr Ala Leu Gly  Glu Ala Arg 
    1640                 1645                 1650             


Asp Glu  Val Val Glu Thr Ala  Phe Glu Met Arg Gln  Pro Ser Ala 
    1655                 1660                 1665             


Arg Ser  Arg Ala Ala Gln Leu  Ala Trp Met Arg Ala  Gln Ile Asp 
    1670                 1675                 1680             


Leu Arg  Gln Leu His Leu Ser  Pro Asp Asp Val Glu  Asp Ala Met 
    1685                 1690                 1695             


Glu Leu  Leu Ser Arg Phe Leu  Ser Arg His Ala Phe  Ser Pro Glu 
    1700                 1705                 1710             


Arg Arg  Ala Ala Ile Leu Gln  Asn Glu Leu Gly Gln  Ser Gly Leu 
    1715                 1720                 1725             


Trp Ala  His Gly Ile Ser Gly  Asp Arg Pro Ile Val  Ala Val Arg 
    1730                 1735                 1740             


Leu Ala  Ser Ala Ala Glu Val  Pro Phe Val Ala Lys  Leu Ala Arg 
    1745                 1750                 1755             


Leu Thr  Gln Tyr Leu Ala His  Met Gly Phe Ala Ser  Asp Leu Val 
    1760                 1765                 1770             


Val Ile  Asp Glu Thr Ile Ser  Ser Tyr Arg Asp Glu  Met Arg Asp 
    1775                 1780                 1785             


Arg Ile  Arg Ala Glu Met Ala  Arg Arg Gly Val His  Asp Ala Ala 
    1790                 1795                 1800             


Thr Leu  Ala Val Val Lys Ala  Asp Gln Leu Ser Ser  Ala Glu Arg 
    1805                 1810                 1815             


Ala Leu  Met Glu Ser Val Ala  Val Ala Thr Leu Arg  Ala Gly Gly 
    1820                 1825                 1830             


Pro Ser  Val Gly Ala Gln Leu  Thr Gly Gly Arg Val  Arg Arg Glu 
    1835                 1840                 1845             


Glu Ser  Ala Arg Leu Ala Ser  Asp Arg Leu Glu Pro  Glu Pro Lys 
    1850                 1855                 1860             


Arg Ala  Pro Arg Asp Ala Gly  Gln Val Glu Gly Glu  Phe Ala Asn 
    1865                 1870                 1875             


Gly Tyr  Gly Ala Phe Val Asp  Asp Gly Arg Ala Tyr  Arg Met Arg 
    1880                 1885                 1890             


Val Thr  Arg Ala Lys Arg Pro  Pro Arg Pro Trp Ser  Asn Val Leu 
    1895                 1900                 1905             


Ala Asn  Pro Asn Phe Gly Ala  Leu Val Thr Glu Leu  Gly Thr Gly 
    1910                 1915                 1920             


Tyr Thr  Trp Trp Arg Asn Ser  Arg Glu Phe Lys Leu  Thr Pro Trp 
    1925                 1930                 1935             


His Asn  Asp Ala Ala Phe Asp  Pro Pro Gly Glu Ala  Val Tyr Ile 
    1940                 1945                 1950             


Ala Asp  Leu Asp Arg Gly Ile  Ile Ala Ser Ala Thr  Pro Ser Pro 
    1955                 1960                 1965             


Ala Gly  Asp Glu Arg Thr Tyr  Asp Val Thr His Arg  Pro Gly Val 
    1970                 1975                 1980             


Thr Thr  Phe Glu Ser Asp Val  Glu Gly Val Arg Val  Thr Leu His 
    1985                 1990                 1995             


Val Phe  Val Asp Ser Ala Glu  Pro Ala Lys Trp Met  Arg Val Arg 
    2000                 2005                 2010             


Leu Arg  Asn Gln Ser Gly Glu  Glu Arg Arg Ile Arg  Val Ala Pro 
    2015                 2020                 2025             


Tyr Ala  Glu Trp Val Leu Gly  Val Asp Pro Phe Ser  Asn Thr Pro 
    2030                 2035                 2040             


Leu Val  Val Val Arg Lys Met  Gly Glu Ala Asp Ala  Ile Ala Ala 
    2045                 2050                 2055             


Glu Asn  Arg Tyr Gln Glu Ala  Phe Arg Gly Ala Leu  Gly Phe Leu 
    2060                 2065                 2070             


Ala Val  Gly Gly Ala Gly Arg  Thr Thr Gly Trp Leu  Gly Asp Lys 
    2075                 2080                 2085             


Thr Arg  Phe Leu Gly Asp Gly  Ser Tyr Ala Arg Pro  Asp Ala Leu 
    2090                 2095                 2100             


Leu Glu  Asp Ala Trp Arg Gly  Gly Asp Gly Pro Thr  Pro Thr Pro 
    2105                 2110                 2115             


Cys Ala  Val Leu Ala Arg Asp  Leu Asp Leu Gly Pro  His Glu Glu 
    2120                 2125                 2130             


Ala Glu  Val Val Ile Leu Leu  Gly Ala Ala Pro Asp  Glu His Glu 
    2135                 2140                 2145             


Ala Ala  Arg Leu Ala Arg Leu  Ala Asp Pro Ala Ala  Ala Asp Arg 
    2150                 2155                 2160             


Ala Leu  Arg Glu Val Thr Arg  Phe Trp Asp Asp Leu  Leu Gly Arg 
    2165                 2170                 2175             


Val Gln  Ile Arg Thr Pro Asp  Arg Ala Phe Asp Ile  Leu Met Asn 
    2180                 2185                 2190             


Gly Trp  Leu Val Tyr Gln Ala  Leu Ala Cys Arg Leu  Trp Ala Arg 
    2195                 2200                 2205             


Thr Ala  Phe Tyr Gln Ala Gly  Gly Ala Phe Gly Phe  Arg Asp Gln 
    2210                 2215                 2220             


Leu Gln  Asp Ala Leu Ala Leu  Ile His Ala Arg Pro  Asp Ile Leu 
    2225                 2230                 2235             


Arg Asp  Gln Ile Leu Arg Ala  Ala Arg His Gln Tyr  Val Glu Gly 
    2240                 2245                 2250             


Asp Val  Gln His Trp Trp His  Glu Glu Leu Gly Lys  Gly Ile Arg 
    2255                 2260                 2265             


Thr Arg  Phe Ser Asp Asp Leu  Leu Trp Leu Pro Tyr  Ala Val Ser 
    2270                 2275                 2280             


Arg Tyr  Leu Glu Ala Thr Gly  Asp Ala Ala Leu Leu  Asp Glu Arg 
    2285                 2290                 2295             


Ala Pro  Tyr Leu Val Ser Ala  Pro Leu Gly Asp Gly  Glu Leu Glu 
    2300                 2305                 2310             


Arg Tyr  Glu Asp Ser Val Trp  Ser Gln Glu Glu Gly  Thr Leu Ala 
    2315                 2320                 2325             


Glu His  Val Ala Arg Ala Val  Glu Arg Ala Leu His  Phe Gly Asp 
    2330                 2335                 2340             


His Gly  Leu Pro Leu Ile Gly  Ile Gly Asp Trp Asn  Asp Gly Leu 
    2345                 2350                 2355             


Ser Arg  Val Gly Ala Lys Gly  Arg Gly Glu Ser Val  Trp Leu Ala 
    2360                 2365                 2370             


Trp Phe  Leu Ala Asp Val Val  Arg Arg Val Ala Glu  Ile Asp His 
    2375                 2380                 2385             


Pro Glu  Phe Ala Gln His Arg  Ala Arg Trp Leu Ala  Met Arg Glu 
    2390                 2395                 2400             


Arg Val  Leu Ala Ala Ala Asn  Glu Ser Ala Trp Asp  Gly Gln Trp 
    2405                 2410                 2415             


Tyr Arg  Arg Ala Ile Thr Asp  Asp Gly Leu Trp Leu  Gly Ser Ala 
    2420                 2425                 2430             


Ala Ser  Pro Ala Cys Arg Val  Asp Ala Ile Ala Gln  Ser Trp Ala 
    2435                 2440                 2445             


Val Ile  Ser Gly Gly Ala Pro  Pro Asp Arg Ala Val  Arg Ala Met 
    2450                 2455                 2460             


Glu Ser  Phe Asp Arg Glu Leu  Val Asp Arg Arg Leu  Gly Val Ala 
    2465                 2470                 2475             


His Leu  Leu Gln Pro Ala Phe  Arg Asp Leu Arg Pro  Ser Pro Gly 
    2480                 2485                 2490             


Tyr Ile  Gln Gly Tyr Pro Pro  Gly Ile Arg Glu Asn  Gly Gly Gln 
    2495                 2500                 2505             


Tyr Thr  His Gly Val Ile Trp  Ser Val Ile Ala Trp  Thr Arg Leu 
    2510                 2515                 2520             


Gly Arg  Ala Asp Glu Ala Tyr  Glu Leu Phe Ser Met  Leu Asn Pro 
    2525                 2530                 2535             


Ile His  His Ala Asp Thr Pro  Arg Glu Val Glu Arg  Tyr Gly Asn 
    2540                 2545                 2550             


Glu Pro  Tyr Val Met Ser Ala  Asp Val Tyr Thr Ala  Glu Pro Asn 
    2555                 2560                 2565             


Val Gly  Gln Gly Gly Trp Ser  Trp Tyr Thr Gly Ala  Ala Ser Trp 
    2570                 2575                 2580             


Met Tyr  Gln Ala Gly Leu Glu  Ala Ile Leu Gly Ile  Arg Arg His 
    2585                 2590                 2595             


Gly Thr  Arg Leu Leu Val Glu  Pro Cys Val Pro Ala  His Trp Pro 
    2600                 2605                 2610             


Gly Phe  Glu Val Ala Tyr Arg  Tyr Gly Ser Thr Leu  Tyr Arg Ile 
    2615                 2620                 2625             


Arg Val  Glu Arg Ala Pro Gln  Gly Ala Glu Ala Arg  Asp Ser Ala 
    2630                 2635                 2640             


Leu Thr  Val Glu Gly Val Ala  Pro Ala Glu Ile Asp  Leu Val Asp 
    2645                 2650                 2655             


Asp Gly  Gln Glu His His Val  Val Val Trp Leu Ala  Ala Glu Gly 
    2660                 2665                 2670             


Ala Glu  Val Leu Ser Asp Val  Gln Thr Val Ala Ala  Arg Pro Arg 
    2675                 2680                 2685             


Glu Gly  Ala Arg Arg Tyr Arg  Met Ser Ser Gly Ala  Arg Ala Phe 
    2690                 2695                 2700             


Pro Ala  Ser Ala Ala Tyr Arg  Lys Arg Asp Pro Gln  Pro 
    2705                 2710                 2715     


<210>  215
<211>  2716
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:202 and encoded by SEQ ID NO:210

<400>  215

Met Ala Phe Asp Thr Glu Leu Glu Lys Arg Ala His Ala Leu Ala Leu 
1               5                   10                  15      


Thr Gln Asp Ile Ser Ser Thr Arg Gly Gly Gly Ser Asp Leu Trp Pro 
            20                  25                  30          


Ile Leu Arg Arg Lys Ala Ala Arg Val Arg Asn Leu Ala Thr Arg Leu 
        35                  40                  45              


Glu Arg Glu Pro Ala Ala Cys Ser Glu Pro Ala His Glu Trp Leu Ile 
    50                  55                  60                  


Asp His Ala Ala Tyr Leu Glu Leu Gln Ala Met Leu Ala Glu Arg Leu 
65                  70                  75                  80  


Trp Pro Asn Ala Val Val Arg Lys Leu Pro Arg Met Ala Glu Thr Gly 
                85                  90                  95      


Glu Pro Arg Val Val Thr Leu Ala Ala Ala Tyr Leu Asp Ala Thr Arg 
            100                 105                 110         


Gly His Val Glu Ala Glu Thr Leu Ile Arg Phe Val Glu Ala Tyr Gln 
        115                 120                 125             


Asp Val Gln Val Leu Thr Thr His Glu Cys His Gln Leu Ala Asn Gly 
    130                 135                 140                 


Leu Arg Val Ala Ile Leu Thr Arg Leu Ala Glu Ala Ser Asp Glu Ile 
145                 150                 155                 160 


Gln His Arg Tyr Glu Thr Cys Arg Ala Val Gly Arg Leu Leu Asp Glu 
                165                 170                 175     


Ile Glu Arg Gly Asp Gly Pro Val Ala Val Arg Arg Ala Ile Asp Arg 
            180                 185                 190         


Phe Ser Lys Gly Arg Gly Leu Gly Ala Val Glu Val Val His Leu Val 
        195                 200                 205             


His His Leu Ser Glu Trp Glu Pro Asp Ser Gln Glu Leu Arg Glu Trp 
    210                 215                 220                 


Leu Ala Ala His Val Ala Asn Ser Ser Glu Ser Ile Glu Arg Leu Thr 
225                 230                 235                 240 


Thr Tyr Glu Ala Glu Trp His Ala Glu Ile Gln Val Leu Ile Gly Asn 
                245                 250                 255     


Leu Val Gln Ser Leu His Ala Leu Glu Arg Met Ser Trp Gln Pro Ile 
            260                 265                 270         


Ala Ser Arg Ile Ser Arg Val Glu Ser Cys Leu Arg Gln Glu Pro Thr 
        275                 280                 285             


Gly Asp Tyr Leu Arg Leu Asp Pro Thr Ser Gln Asn Val Leu Thr Gln 
    290                 295                 300                 


Gln Val Ser Trp Leu Ser Glu Ala Phe Arg Leu Pro Glu Ala Met Ile 
305                 310                 315                 320 


Ala Glu Thr Ala Val Ser Leu Ala Arg Glu Ala Trp Glu Lys Ala Gly 
                325                 330                 335     


Ser Pro Thr Ala Ser Ser Asp Leu Pro Arg Glu Ala Phe Val Ala Tyr 
            340                 345                 350         


Tyr Leu Cys Asp Pro Asp Gly Met His Ala Leu His Arg Ser Leu Lys 
        355                 360                 365             


Glu Arg Ala Lys Pro Arg Ser Val Pro Gln Ile Ala Leu Arg Arg Arg 
    370                 375                 380                 


Pro Leu Arg Ser Tyr Leu Leu Gly Val Ala Phe Leu Phe Ala Ala Ile 
385                 390                 395                 400 


Leu Trp Ala Val Leu Gly Gly Phe Thr Gly Gly Phe Arg Ala Pro Leu 
                405                 410                 415     


Gly Ala Thr Leu Ala Leu Ala Val Leu Leu Ala Leu Pro Val Ser Glu 
            420                 425                 430         


Trp Val Ile Ser Leu Val His Glu Gly Ile Arg Arg Ala Val Arg Pro 
        435                 440                 445             


Val Pro Leu Leu Arg Leu Asp Phe Ser Glu Gly Ile Pro Glu Asp Ala 
    450                 455                 460                 


Arg Thr Leu Ile Val Leu Pro Val Ile Trp Ala Ser Glu Ala Asp Val 
465                 470                 475                 480 


Asp Glu Ala Phe Asp Lys Ile Glu Leu His His Leu Thr Asn Arg Gly 
                485                 490                 495     


Ala His Leu Tyr Phe Ala Val Leu Ser Asp Leu Arg Asp Ala Asp Ala 
            500                 505                 510         


Pro His Leu Pro Glu Asp Glu Pro Leu Leu Ala Arg Ala Arg Ala Arg 
        515                 520                 525             


Leu Glu Ala Leu Arg His Lys Tyr Gly Ala Ala Arg Phe Phe Trp Phe 
    530                 535                 540                 


His Arg Asp Arg Val Leu Asn Arg Ala Asp Gly Val Tyr Met Gly Trp 
545                 550                 555                 560 


Glu Arg Lys Arg Gly Lys Leu Val Glu Phe Val Glu Leu Leu Arg Gly 
                565                 570                 575     


Lys Arg Asp Thr Thr Phe Arg Val Lys Asp Gly Asp Leu Ala Val Leu 
            580                 585                 590         


Pro Thr Ile Arg Tyr Val Phe Thr Ala Asp Leu Asp Thr Glu Leu Pro 
        595                 600                 605             


Ile Gly Thr Val Gln Arg Leu Val Gly Thr Met His Leu Pro Tyr Asn 
    610                 615                 620                 


Arg Pro Arg Leu Asn Ala Arg Gly Thr Arg Val Asp Gln Gly Tyr Gly 
625                 630                 635                 640 


Val Leu Gln Pro Ala Val Ala Val Ser Pro Arg Ser Thr Gln Ala Ser 
                645                 650                 655     


Arg Phe Ala Arg Leu Trp Ser Gly Glu Thr Gly Val Asp Pro Tyr Ala 
            660                 665                 670         


Phe Ala Ile Ser Asn Pro Tyr Gln Asp Trp Phe Gly Arg Gly Leu Phe 
        675                 680                 685             


Val Gly Lys Gly Leu Ile His Val Asp Ala Phe His Thr Val Leu Cys 
    690                 695                 700                 


Asp Arg Ile Pro Asp Asn Arg Val Leu Ser His Asp Ile Leu Glu Gly 
705                 710                 715                 720 


Gly Phe Leu Arg Ala Gly Leu Val Ala Asp Val Glu Val Val Glu Ser 
                725                 730                 735     


Gln Pro Ala Thr Leu Arg Ala Tyr Met Arg Arg Ala His Arg Trp Val 
            740                 745                 750         


Arg Gly Asp Trp Gln Leu Thr Tyr Trp Leu Arg Arg Val Cys Arg Asp 
        755                 760                 765             


Arg Arg Gly Glu Thr Gln Pro Val Asp Leu Cys Gly Phe Thr Arg Trp 
    770                 775                 780                 


Asn Ile Val Asp His Val Arg His Ser Leu Val Asn Pro Ala Leu Val 
785                 790                 795                 800 


Leu Leu Met Gly Ser Gly Met Ser Gly Leu Leu Pro Gly Pro Ala Tyr 
                805                 810                 815     


Ala Tyr Gly Ala Val Leu Leu Ile Thr Val Phe Leu Pro Phe Leu Arg 
            820                 825                 830         


Gln Leu Glu Ser Ile Arg Pro Gly Glu Trp Asp Trp Arg Ser Ala Ala 
        835                 840                 845             


Thr Ala Leu Gly Gln Ser Leu Val Met Leu Val Thr Leu Pro Phe Met 
    850                 855                 860                 


Ala Val Val Glu Ala Asp Ala Ser Leu Arg Ala Leu Tyr Arg Met Leu 
865                 870                 875                 880 


Val Ser Arg Arg Arg Leu Leu Glu Trp Ile Pro Ser Ser His Ala Asp 
                885                 890                 895     


Arg Ser Asp Gly Ser Pro Ala Pro Leu Leu Tyr Glu Pro Ala Gly Tyr 
            900                 905                 910         


Ala Val Ala Leu Ala Cys Ser Val Pro Gly Leu Phe Gly Thr Trp Glu 
        915                 920                 925             


Gln Ala Leu Ser Ser Thr Leu Ala Leu Ala Val Trp Leu Pro Ala His 
    930                 935                 940                 


Ala Val Ala Arg Phe Leu Ala Lys Pro Ala Gly Glu Ala Arg Val Ala 
945                 950                 955                 960 


Ala Pro Asp Pro Ala Leu Ser Ala His Leu Arg Glu Val Ala Thr Ala 
                965                 970                 975     


Met Trp Arg Phe Tyr Glu Arg Tyr Val Gly Glu Glu Asp His His Leu 
            980                 985                 990         


Pro Pro Asp Asn Val Gln Phe Glu  Pro Val Glu Arg Ile  Ala His Arg 
        995                 1000                 1005             


Thr Ser  Pro Thr Asn Ile Gly  Leu Tyr Leu Leu Cys  Val Ala Ala 
    1010                 1015                 1020             


Ala Ala  Asp Leu Glu Ile Ile  Pro Lys Glu Gly Ala  Ile Ala Arg 
    1025                 1030                 1035             


Leu Glu  Arg Thr Leu Ala Thr  Leu Thr Ser Leu Asp  Arg Trp His 
    1040                 1045                 1050             


Gly His  Leu Phe Asn Trp Tyr  Asp Thr Arg Thr Leu  Arg Pro Leu 
    1055                 1060                 1065             


Ala Pro  Arg Tyr Val Ser Thr  Val Asp Ser Gly Asn  Leu Val Cys 
    1070                 1075                 1080             


Ala Met  Leu Ala Leu Gly Gln  Ala Leu Arg Glu Trp  Ala Ala Ser 
    1085                 1090                 1095             


Asp Ala  Asp Ile Ala Pro Arg  Ala Arg Arg Leu Ala  Asp Ala Met 
    1100                 1105                 1110             


Glu Gly  Phe Ala Arg Glu Ile  Asp Phe Arg Pro Leu  Tyr Arg Pro 
    1115                 1120                 1125             


Asp Leu  Arg Leu Phe Ser Leu  Gly Phe His Ala Asp  Arg Asn Glu 
    1130                 1135                 1140             


Leu Glu  Asn Ile Val Tyr Asp  Leu Leu Ala Ser Glu  Ala Arg Gln 
    1145                 1150                 1155             


Ala Ser  Phe Ile Ala Ile Ala  Ser Gly Gln Val Pro  Ala Ser His 
    1160                 1165                 1170             


Trp Phe  Ala Leu Ser Arg Thr  Met Thr Arg Ala Gly  Arg Tyr Gln 
    1175                 1180                 1185             


Pro Leu  Leu Ser Trp Ser Gly  Thr Met Phe Glu Tyr  Leu Met Pro 
    1190                 1195                 1200             


Ala Leu  Leu Met Arg His Leu  Pro His Thr Leu Trp  Glu Glu Thr 
    1205                 1210                 1215             


Tyr Arg  Gly Val Val Trp Arg  Gln Ile Ala Tyr Ala  Arg Glu Arg 
    1220                 1225                 1230             


Gly Val  Pro Phe Gly Ile Ser  Glu Ser Gly Phe Tyr  Ala Phe Asp 
    1235                 1240                 1245             


Arg Asp  Leu Asn Tyr Gln Tyr  Arg Ala Phe Gly Val  Pro Gly Leu 
    1250                 1255                 1260             


Gly Leu  Asp Arg Gly Leu Glu  Gln His Leu Val Val  Ala Pro Tyr 
    1265                 1270                 1275             


Ala Thr  Met Leu Ala Leu Pro  Phe Ala Pro Glu Gln  Val Ala Glu 
    1280                 1285                 1290             


Ala Leu  Arg Gln Leu Arg Glu  Leu Gly Ala Leu Gly  Pro Tyr Gly 
    1295                 1300                 1305             


Tyr Tyr  Glu Ala Val Asp Phe  Thr Ala Ser Arg Leu  Pro Pro Gly 
    1310                 1315                 1320             


Asp Arg  Tyr Lys Val Val Gln  Ser Phe Met Ala His  His Gln Gly 
    1325                 1330                 1335             


Met Ala  Phe Ile Ala Ile Ala  Asn Tyr Leu Asn Arg  Asn Leu Trp 
    1340                 1345                 1350             


Val Glu  Arg Phe His Arg Leu  Pro Leu Val Arg Ala  Ala Glu Tyr 
    1355                 1360                 1365             


Met Leu  Tyr Glu Arg Met Pro  Lys Arg Pro Ala Leu  Leu Leu Lys 
    1370                 1375                 1380             


Pro Val  His Ala Ala His Ala  Pro Asn Phe Asp Arg  Pro Val Tyr 
    1385                 1390                 1395             


Ala Arg  Arg Arg Ser Gly Asp  Asp Val Ala Trp Asn  Ala Val Ser 
    1400                 1405                 1410             


Asn Gly  Ser Leu Thr Ser Phe  Ala Asp Ala Arg Gly  Glu Gly Gly 
    1415                 1420                 1425             


Ile Ala  Trp Arg Gly Ile Ala  Val Thr Arg Tyr Arg  Pro Asp Arg 
    1430                 1435                 1440             


His Leu  Pro Tyr Arg Gly Pro  Val Met Tyr Val Arg  Asp Val Asp 
    1445                 1450                 1455             


Arg Gly  Gly Val Phe Arg Thr  Thr Leu His Gly Gly  Gly Gly His 
    1460                 1465                 1470             


Val Glu  Ala Glu Phe Arg Pro  Asp Lys Ser Ser Trp  Lys Arg Val 
    1475                 1480                 1485             


Val Asp  Gly Ile Glu Ser Glu  Trp Ser Val Leu Val  Ala Pro Asp 
    1490                 1495                 1500             


Arg Asp  Val Glu Ile Arg Thr  Leu Val Leu Gln Asn  Leu Gly Glu 
    1505                 1510                 1515             


Asp Val  Arg Arg Leu Glu Val  Thr Tyr Phe Ala Glu  Leu Ala Leu 
    1520                 1525                 1530             


Ala Lys  Pro Ala Ala Asp Ile  Ala His Pro Ser Phe  Gln Arg Leu 
    1535                 1540                 1545             


Phe Val  Glu Thr Gly Trp Asp  Asp Ala Arg Gln Val  Leu Trp Ala 
    1550                 1555                 1560             


Gln Arg  Arg Pro Glu Ser Asp  Asp Gln Pro Asp Val  Tyr Ala Ala 
    1565                 1570                 1575             


Phe His  Leu Val Ala Asp Glu  Glu Ala Pro Ala Pro  Val Glu Trp 
    1580                 1585                 1590             


Asp Ser  His Arg Ala Arg Phe  Val Gly Arg Gly Gly  Ser Leu Ala 
    1595                 1600                 1605             


Ala Pro  Arg Gly Leu Trp Arg  Arg Leu Arg Gly Glu  Gly Val Ala 
    1610                 1615                 1620             


Asp Pro  Ala Ala Ile Leu Arg  Thr Ala Val Thr Leu  Ala Pro Gly 
    1625                 1630                 1635             


Glu Lys  Arg Ala Leu Tyr Val  Ile Thr Ala Leu Gly  Glu Ala Arg 
    1640                 1645                 1650             


Asp Glu  Val Val Glu Thr Ala  Phe Glu Met Arg Gln  Pro Ser Ala 
    1655                 1660                 1665             


Arg Ser  Arg Ala Ala Gln Leu  Ala Trp Met Arg Ala  Gln Ile Asp 
    1670                 1675                 1680             


Leu Arg  Gln Leu His Leu Ser  Pro Asp Asp Val Glu  Asp Ala Met 
    1685                 1690                 1695             


Glu Leu  Leu Ser Arg Phe Leu  Ser Arg His Ala Phe  Ser Pro Glu 
    1700                 1705                 1710             


Arg Arg  Ala Ala Ile Leu Gln  Asn Glu Leu Gly Gln  Ser Gly Leu 
    1715                 1720                 1725             


Trp Ala  His Gly Ile Ser Gly  Asp Arg Pro Ile Val  Ala Val Arg 
    1730                 1735                 1740             


Leu Ala  Ser Ala Ala Glu Val  Pro Phe Val Ala Lys  Leu Ala Arg 
    1745                 1750                 1755             


Leu Thr  Gln Tyr Leu Ala His  Met Gly Phe Ala Ser  Asp Leu Val 
    1760                 1765                 1770             


Val Ile  Asp Glu Thr Ile Ser  Ser Tyr Arg Asp Glu  Met Arg Asp 
    1775                 1780                 1785             


Arg Ile  Arg Ala Glu Met Ala  Arg Arg Gly Val His  Asp Ala Ala 
    1790                 1795                 1800             


Thr Leu  Ala Val Val Lys Ala  Asp Gln Leu Ser Ser  Ala Glu Arg 
    1805                 1810                 1815             


Ala Leu  Met Glu Ser Val Ala  Val Ala Thr Leu Arg  Ala Gly Gly 
    1820                 1825                 1830             


Pro Ser  Val Gly Ala Gln Leu  Thr Gly Gly Arg Val  Arg Arg Glu 
    1835                 1840                 1845             


Glu Ser  Ala Arg Leu Ala Ser  Asp Arg Leu Glu Pro  Glu Pro Lys 
    1850                 1855                 1860             


Arg Ala  Pro Arg Asp Ala Gly  Gln Val Glu Gly Glu  Phe Ala Asn 
    1865                 1870                 1875             


Gly Tyr  Gly Ala Phe Val Asp  Asp Gly Arg Ala Tyr  Arg Met Arg 
    1880                 1885                 1890             


Val Thr  Arg Ala Lys Arg Pro  Pro Arg Pro Trp Ser  Asn Val Leu 
    1895                 1900                 1905             


Ala Asn  Pro Asn Phe Gly Ala  Leu Val Thr Glu Leu  Gly Thr Gly 
    1910                 1915                 1920             


Tyr Thr  Trp Trp Arg Asn Ser  Arg Glu Phe Lys Leu  Thr Pro Trp 
    1925                 1930                 1935             


His Asn  Asp Ala Ala Phe Asp  Pro Pro Gly Glu Ala  Val Tyr Ile 
    1940                 1945                 1950             


Ala Asp  Leu Asp Arg Gly Ile  Ile Ala Ser Ala Thr  Pro Ser Pro 
    1955                 1960                 1965             


Ala Gly  Asp Glu Arg Thr Tyr  Asp Val Thr His Arg  Pro Gly Val 
    1970                 1975                 1980             


Thr Thr  Phe Glu Ser Asp Val  Glu Gly Val Arg Val  Thr Leu His 
    1985                 1990                 1995             


Val Phe  Val Asp Ser Ala Glu  Pro Ala Lys Trp Met  Arg Val Arg 
    2000                 2005                 2010             


Leu Arg  Asn Gln Ser Gly Glu  Glu Arg Arg Ile Arg  Val Ala Pro 
    2015                 2020                 2025             


Tyr Ala  Glu Trp Val Leu Gly  Val Asp Pro Phe Ser  Asn Thr Pro 
    2030                 2035                 2040             


Leu Val  Val Val Arg Lys Met  Gly Glu Ala Asp Ala  Ile Ala Ala 
    2045                 2050                 2055             


Glu Asn  Arg Tyr Gln Glu Ala  Phe Arg Gly Ala Leu  Gly Phe Leu 
    2060                 2065                 2070             


Ala Val  Gly Gly Ala Gly Arg  Thr Thr Gly Trp Leu  Gly Asp Lys 
    2075                 2080                 2085             


Thr Arg  Phe Leu Gly Asp Gly  Ser Tyr Ala Arg Pro  Asp Ala Leu 
    2090                 2095                 2100             


Leu Glu  Asp Ala Trp Arg Gly  Gly Asp Gly Pro Thr  Pro Thr Pro 
    2105                 2110                 2115             


Cys Ala  Val Leu Ala Arg Asp  Leu Asp Leu Gly Pro  His Glu Glu 
    2120                 2125                 2130             


Ala Glu  Val Val Ile Leu Leu  Gly Ala Ala Pro Asp  Glu His Glu 
    2135                 2140                 2145             


Ala Ala  Arg Leu Ala Arg Leu  Ala Asp Pro Ala Ala  Ala Asp Arg 
    2150                 2155                 2160             


Ala Leu  Arg Glu Val Thr Arg  Phe Trp Asp Asp Leu  Leu Gly Arg 
    2165                 2170                 2175             


Val Gln  Ile Arg Thr Pro Asp  Arg Ala Phe Asp Ile  Leu Met Asn 
    2180                 2185                 2190             


Gly Trp  Leu Val Tyr Gln Ala  Leu Ala Cys Arg Leu  Trp Ala Arg 
    2195                 2200                 2205             


Thr Ala  Phe Tyr Gln Ala Gly  Gly Ala Phe Gly Phe  Arg Asp Gln 
    2210                 2215                 2220             


Leu Gln  Asp Ala Leu Ala Leu  Ile His Ala Arg Pro  Asp Ile Leu 
    2225                 2230                 2235             


Arg Asp  Gln Ile Leu Arg Ala  Ala Arg His Gln Tyr  Val Glu Gly 
    2240                 2245                 2250             


Asp Val  Gln His Trp Trp His  Glu Glu Leu Gly Lys  Gly Ile Arg 
    2255                 2260                 2265             


Thr Arg  Phe Ser Asp Asp Leu  Leu Trp Leu Pro Tyr  Ala Val Ser 
    2270                 2275                 2280             


Arg Tyr  Leu Glu Ala Thr Gly  Asp Ala Ala Leu Leu  Asp Glu Arg 
    2285                 2290                 2295             


Ala Pro  Tyr Leu Val Ser Ala  Pro Leu Gly Asp Gly  Glu Leu Glu 
    2300                 2305                 2310             


Arg Tyr  Glu Asp Ser Val Trp  Ser Gln Glu Glu Gly  Thr Leu Ala 
    2315                 2320                 2325             


Glu His  Val Ala Arg Ala Val  Glu Arg Ala Leu His  Phe Gly Asp 
    2330                 2335                 2340             


His Gly  Leu Pro Leu Ile Gly  Ile Gly Asp Trp Asn  Asp Gly Leu 
    2345                 2350                 2355             


Ser Arg  Val Gly Ala Lys Gly  Arg Gly Glu Ser Val  Trp Leu Ala 
    2360                 2365                 2370             


Trp Phe  Leu Ala Asp Val Val  Arg Arg Val Ala Glu  Ile Asp His 
    2375                 2380                 2385             


Pro Glu  Phe Ala Gln His Arg  Ala Arg Trp Leu Ala  Met Arg Glu 
    2390                 2395                 2400             


Arg Val  Leu Ala Ala Ala Asn  Glu Ser Ala Trp Asp  Gly Gln Trp 
    2405                 2410                 2415             


Tyr Arg  Arg Ala Ile Thr Asp  Asp Gly Leu Trp Leu  Gly Ser Ala 
    2420                 2425                 2430             


Ala Ser  Pro Ala Cys Arg Val  Asp Ala Ile Ala Gln  Ser Trp Ala 
    2435                 2440                 2445             


Val Ile  Ser Gly Gly Ala Pro  Pro Asp Arg Ala Val  Arg Ala Met 
    2450                 2455                 2460             


Glu Ser  Phe Asp Arg Glu Leu  Val Asp Arg Arg Leu  Gly Val Ala 
    2465                 2470                 2475             


His Leu  Leu Gln Pro Ala Phe  Arg Asp Leu Arg Pro  Ser Pro Gly 
    2480                 2485                 2490             


Tyr Ile  Gln Gly Tyr Pro Pro  Gly Ile Arg Glu Asn  Gly Gly Gln 
    2495                 2500                 2505             


Tyr Thr  His Gly Val Ile Trp  Ser Val Ile Ala Trp  Thr Arg Leu 
    2510                 2515                 2520             


Gly Arg  Ala Asp Glu Ala Tyr  Glu Leu Phe Ser Met  Leu Asn Pro 
    2525                 2530                 2535             


Ile His  His Ala Asp Thr Pro  Arg Glu Val Glu Arg  Tyr Gly Asn 
    2540                 2545                 2550             


Glu Pro  Tyr Val Met Ser Ala  Asp Val Tyr Thr Ala  Glu Pro Asn 
    2555                 2560                 2565             


Val Gly  Gln Gly Gly Trp Ser  Trp Tyr Thr Gly Ala  Ala Ser Trp 
    2570                 2575                 2580             


Met Tyr  Gln Ala Gly Leu Glu  Ala Ile Leu Gly Ile  Arg Arg His 
    2585                 2590                 2595             


Gly Thr  Arg Leu Leu Val Glu  Pro Cys Val Pro Ala  His Trp Pro 
    2600                 2605                 2610             


Gly Phe  Glu Val Ala Tyr Arg  Tyr Gly Ser Thr Leu  Tyr Arg Ile 
    2615                 2620                 2625             


Arg Val  Glu Arg Ala Pro Gln  Gly Ala Glu Ala Arg  Asp Ser Ala 
    2630                 2635                 2640             


Leu Thr  Val Glu Gly Val Ala  Pro Ala Glu Ile Asp  Leu Val Asp 
    2645                 2650                 2655             


Asp Gly  Gln Glu His His Val  Val Val Trp Leu Ala  Ala Glu Gly 
    2660                 2665                 2670             


Ala Glu  Val Leu Ser Asp Val  Gln Thr Val Ala Ala  Arg Pro Arg 
    2675                 2680                 2685             


Glu Gly  Ala Arg Arg Tyr Arg  Met Ser Ser Gly Ala  Arg Ala Phe 
    2690                 2695                 2700             


Pro Ala  Ser Ala Ala Tyr Arg  Lys Arg Asp Pro Gln  Pro 
    2705                 2710                 2715     


<210>  216
<211>  2716
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:202 and encoded by SEQ ID NO:211

<400>  216

Met Ala Phe Asp Thr Glu Leu Glu Arg Lys Ala His Ala Leu Ala Leu 
1               5                   10                  15      


Thr Gln Asp Ile Ser Ser Thr Arg Gly Gly Gly Ser Asp Leu Trp Pro 
            20                  25                  30          


Ile Leu Arg Arg Lys Ala Ala Arg Val Arg Asn Leu Ala Thr Arg Leu 
        35                  40                  45              


Glu Arg Glu Pro Ala Ala Cys Ser Glu Pro Ala His Glu Trp Leu Ile 
    50                  55                  60                  


Asp His Ala Ala Tyr Leu Glu Leu Gln Ala Met Leu Ala Glu Arg Leu 
65                  70                  75                  80  


Trp Pro Asn Ala Val Val Arg Lys Leu Pro Arg Met Ala Glu Thr Gly 
                85                  90                  95      


Glu Pro Arg Val Val Thr Leu Ala Ala Ala Tyr Leu Asp Ala Thr Arg 
            100                 105                 110         


Gly His Val Glu Ala Glu Thr Leu Ile Arg Phe Val Glu Ala Tyr Gln 
        115                 120                 125             


Asp Val Gln Val Leu Thr Thr His Glu Cys His Gln Leu Ala Asn Gly 
    130                 135                 140                 


Leu Arg Val Ala Ile Leu Thr Arg Leu Ala Glu Ala Ser Asp Glu Ile 
145                 150                 155                 160 


Gln His Arg Tyr Glu Thr Cys Arg Ala Val Gly Arg Leu Leu Asp Glu 
                165                 170                 175     


Ile Glu Arg Gly Asp Gly Pro Val Ala Val Arg Arg Ala Ile Asp Arg 
            180                 185                 190         


Phe Ser Lys Gly Arg Gly Leu Gly Ala Val Glu Val Val His Leu Val 
        195                 200                 205             


His His Leu Ser Glu Trp Glu Pro Asp Ser Gln Glu Leu Arg Glu Trp 
    210                 215                 220                 


Leu Ala Ala His Val Ala Asn Ser Ser Glu Ser Ile Glu Arg Leu Thr 
225                 230                 235                 240 


Thr Tyr Glu Ala Glu Trp His Ala Glu Ile Gln Val Leu Ile Gly Asn 
                245                 250                 255     


Leu Val Gln Ser Leu His Ala Leu Glu Arg Met Ser Trp Gln Pro Ile 
            260                 265                 270         


Ala Ser Arg Ile Ser Arg Val Glu Ser Cys Leu Arg Gln Glu Pro Thr 
        275                 280                 285             


Gly Asp Tyr Leu Arg Leu Asp Pro Thr Ser Gln Asn Val Leu Thr Gln 
    290                 295                 300                 


Gln Val Ser Trp Leu Ser Glu Ala Phe Arg Leu Pro Glu Ala Met Ile 
305                 310                 315                 320 


Ala Glu Thr Ala Val Ser Leu Ala Arg Glu Ala Trp Glu Lys Ala Gly 
                325                 330                 335     


Ser Pro Thr Ala Ser Ser Asp Leu Pro Arg Glu Ala Phe Val Ala Tyr 
            340                 345                 350         


Tyr Leu Cys Asp Pro Asp Gly Met His Ala Leu His Arg Ser Leu Lys 
        355                 360                 365             


Glu Arg Ala Lys Pro Arg Ser Val Pro Gln Ile Ala Leu Arg Arg Arg 
    370                 375                 380                 


Pro Leu Arg Ser Tyr Leu Leu Gly Val Ala Phe Leu Phe Ala Ala Ile 
385                 390                 395                 400 


Leu Trp Ala Val Leu Gly Gly Phe Thr Gly Gly Phe Arg Ala Pro Leu 
                405                 410                 415     


Gly Ala Thr Leu Ala Leu Ala Val Leu Leu Ala Leu Pro Val Ser Glu 
            420                 425                 430         


Trp Val Ile Ser Leu Val His Glu Gly Ile Arg Arg Ala Val Arg Pro 
        435                 440                 445             


Val Pro Leu Leu Arg Leu Asp Phe Ser Glu Gly Ile Pro Glu Asp Ala 
    450                 455                 460                 


Arg Thr Leu Ile Val Leu Pro Val Ile Trp Ala Ser Glu Ala Asp Val 
465                 470                 475                 480 


Asp Glu Ala Phe Asp Lys Ile Glu Leu His His Leu Thr Asn Arg Gly 
                485                 490                 495     


Ala His Leu Tyr Phe Ala Val Leu Ser Asp Leu Arg Asp Ala Asp Ala 
            500                 505                 510         


Pro His Leu Pro Glu Asp Glu Pro Leu Leu Ala Arg Ala Arg Ala Arg 
        515                 520                 525             


Leu Glu Ala Leu Arg His Lys Tyr Gly Ala Ala Arg Phe Phe Trp Phe 
    530                 535                 540                 


His Arg Asp Arg Val Leu Asn Arg Ala Asp Gly Val Tyr Met Gly Trp 
545                 550                 555                 560 


Glu Arg Lys Arg Gly Lys Leu Val Glu Phe Val Glu Leu Leu Arg Gly 
                565                 570                 575     


Lys Arg Asp Thr Thr Phe Arg Val Lys Asp Gly Asp Leu Ala Val Leu 
            580                 585                 590         


Pro Thr Ile Arg Tyr Val Phe Thr Ala Asp Leu Asp Thr Glu Leu Pro 
        595                 600                 605             


Ile Gly Thr Val Gln Arg Leu Val Gly Thr Met His Leu Pro Tyr Asn 
    610                 615                 620                 


Arg Pro Arg Leu Asn Ala Arg Gly Thr Arg Val Asp Gln Gly Tyr Gly 
625                 630                 635                 640 


Val Leu Gln Pro Ala Val Ala Val Ser Pro Arg Ser Thr Gln Ala Ser 
                645                 650                 655     


Arg Phe Ala Arg Leu Trp Ser Gly Glu Thr Gly Val Asp Pro Tyr Ala 
            660                 665                 670         


Phe Ala Ile Ser Asn Pro Tyr Gln Asp Trp Phe Gly Arg Gly Leu Phe 
        675                 680                 685             


Val Gly Lys Gly Leu Ile His Val Asp Ala Phe His Thr Val Leu Cys 
    690                 695                 700                 


Asp Arg Ile Pro Asp Asn Arg Val Leu Ser His Asp Ile Leu Glu Gly 
705                 710                 715                 720 


Gly Phe Leu Arg Ala Gly Leu Val Ala Asp Val Glu Val Val Glu Ser 
                725                 730                 735     


Gln Pro Ala Thr Leu Arg Ala Tyr Met Arg Arg Ala His Arg Trp Val 
            740                 745                 750         


Arg Gly Asp Trp Gln Leu Thr Tyr Trp Leu Arg Arg Val Cys Arg Asp 
        755                 760                 765             


Arg Arg Gly Glu Thr Gln Pro Val Asp Leu Cys Gly Phe Thr Arg Trp 
    770                 775                 780                 


Asn Ile Val Asp His Val Arg His Ser Leu Val Asn Pro Ala Leu Val 
785                 790                 795                 800 


Leu Leu Met Gly Ser Gly Met Ser Gly Leu Leu Pro Gly Pro Ala Tyr 
                805                 810                 815     


Ala Tyr Gly Ala Val Leu Leu Ile Thr Val Phe Leu Pro Phe Leu Arg 
            820                 825                 830         


Gln Leu Glu Ser Ile Arg Pro Gly Glu Trp Asp Trp Arg Ser Ala Ala 
        835                 840                 845             


Thr Ala Leu Gly Gln Ser Leu Val Met Leu Val Thr Leu Pro Phe Met 
    850                 855                 860                 


Ala Val Val Glu Ala Asp Ala Ser Leu Arg Ala Leu Tyr Arg Met Leu 
865                 870                 875                 880 


Val Ser Arg Arg Arg Leu Leu Glu Trp Ile Pro Ser Ser His Ala Asp 
                885                 890                 895     


Arg Ser Asp Gly Ser Pro Ala Pro Leu Leu Tyr Glu Pro Ala Gly Tyr 
            900                 905                 910         


Ala Val Ala Leu Ala Cys Ser Val Pro Gly Leu Phe Gly Thr Trp Glu 
        915                 920                 925             


Gln Ala Leu Ser Ser Thr Leu Ala Leu Ala Val Trp Leu Pro Ala His 
    930                 935                 940                 


Ala Val Ala Arg Phe Leu Ala Lys Pro Ala Gly Glu Ala Arg Val Ala 
945                 950                 955                 960 


Ala Pro Asp Pro Ala Leu Ser Ala His Leu Arg Glu Val Ala Thr Ala 
                965                 970                 975     


Met Trp Arg Phe Tyr Glu Arg Tyr Val Gly Glu Glu Asp His His Leu 
            980                 985                 990         


Pro Pro Asp Asn Val Gln Phe Glu  Pro Val Glu Arg Ile  Ala His Arg 
        995                 1000                 1005             


Thr Ser  Pro Thr Asn Ile Gly  Leu Tyr Leu Leu Cys  Val Ala Ala 
    1010                 1015                 1020             


Ala Ala  Asp Leu Glu Ile Ile  Pro Lys Glu Gly Ala  Ile Ala Arg 
    1025                 1030                 1035             


Leu Glu  Arg Thr Leu Ala Thr  Leu Thr Ser Leu Asp  Arg Trp His 
    1040                 1045                 1050             


Gly His  Leu Phe Asn Trp Tyr  Asp Thr Arg Thr Leu  Arg Pro Leu 
    1055                 1060                 1065             


Ala Pro  Arg Tyr Val Ser Thr  Val Asp Ser Gly Asn  Leu Val Cys 
    1070                 1075                 1080             


Ala Met  Leu Ala Leu Gly Gln  Ala Leu Arg Glu Trp  Ala Ala Ser 
    1085                 1090                 1095             


Asp Ala  Asp Ile Ala Pro Arg  Ala Arg Arg Leu Ala  Asp Ala Met 
    1100                 1105                 1110             


Glu Gly  Phe Ala Arg Glu Ile  Asp Phe Arg Pro Leu  Tyr Arg Pro 
    1115                 1120                 1125             


Asp Leu  Arg Leu Phe Ser Leu  Gly Phe His Ala Asp  Arg Asn Glu 
    1130                 1135                 1140             


Leu Glu  Asn Ile Val Tyr Asp  Leu Leu Ala Ser Glu  Ala Arg Gln 
    1145                 1150                 1155             


Ala Ser  Phe Ile Ala Ile Ala  Ser Gly Gln Val Pro  Ala Ser His 
    1160                 1165                 1170             


Trp Phe  Ala Leu Ser Arg Thr  Met Thr Arg Ala Gly  Arg Tyr Gln 
    1175                 1180                 1185             


Pro Leu  Leu Ser Trp Ser Gly  Thr Met Phe Glu Tyr  Leu Met Pro 
    1190                 1195                 1200             


Ala Leu  Leu Met Arg His Leu  Pro His Thr Leu Trp  Glu Glu Thr 
    1205                 1210                 1215             


Tyr Arg  Gly Val Val Trp Arg  Gln Ile Ala Tyr Ala  Arg Glu Arg 
    1220                 1225                 1230             


Gly Val  Pro Phe Gly Ile Ser  Glu Ser Gly Phe Tyr  Ala Phe Asp 
    1235                 1240                 1245             


Arg Asp  Leu Asn Tyr Gln Tyr  Arg Ala Phe Gly Val  Pro Gly Leu 
    1250                 1255                 1260             


Gly Leu  Asp Arg Gly Leu Glu  Gln His Leu Val Val  Ala Pro Tyr 
    1265                 1270                 1275             


Ala Thr  Met Leu Ala Leu Pro  Phe Ala Pro Glu Gln  Val Ala Glu 
    1280                 1285                 1290             


Ala Leu  Arg Gln Leu Arg Glu  Leu Gly Ala Leu Gly  Pro Tyr Gly 
    1295                 1300                 1305             


Tyr Tyr  Glu Ala Val Asp Phe  Thr Ala Ser Arg Leu  Pro Pro Gly 
    1310                 1315                 1320             


Asp Arg  Tyr Lys Val Val Gln  Ser Phe Met Ala His  His Gln Gly 
    1325                 1330                 1335             


Met Ala  Phe Ile Ala Ile Ala  Asn Tyr Leu Asn Arg  Asn Leu Trp 
    1340                 1345                 1350             


Val Glu  Arg Phe His Arg Leu  Pro Leu Val Arg Ala  Ala Glu Tyr 
    1355                 1360                 1365             


Met Leu  Tyr Glu Arg Met Pro  Lys Arg Pro Ala Leu  Leu Leu Lys 
    1370                 1375                 1380             


Pro Val  His Ala Ala His Ala  Pro Asn Phe Asp Arg  Pro Val Tyr 
    1385                 1390                 1395             


Ala Arg  Arg Arg Ser Gly Asp  Asp Val Ala Trp Asn  Ala Val Ser 
    1400                 1405                 1410             


Asn Gly  Ser Leu Thr Ser Phe  Ala Asp Ala Arg Gly  Glu Gly Gly 
    1415                 1420                 1425             


Ile Ala  Trp Arg Gly Ile Ala  Val Thr Arg Tyr Arg  Pro Asp Arg 
    1430                 1435                 1440             


His Leu  Pro Tyr Arg Gly Pro  Val Met Tyr Val Arg  Asp Val Asp 
    1445                 1450                 1455             


Arg Gly  Gly Val Phe Arg Thr  Thr Leu His Gly Gly  Gly Gly His 
    1460                 1465                 1470             


Val Glu  Ala Glu Phe Arg Pro  Asp Lys Ser Ser Trp  Lys Arg Val 
    1475                 1480                 1485             


Val Asp  Gly Ile Glu Ser Glu  Trp Ser Val Leu Val  Ala Pro Asp 
    1490                 1495                 1500             


Arg Asp  Val Glu Ile Arg Thr  Leu Val Leu Gln Asn  Leu Gly Glu 
    1505                 1510                 1515             


Asp Val  Arg Arg Leu Glu Val  Thr Tyr Phe Ala Glu  Leu Ala Leu 
    1520                 1525                 1530             


Ala Lys  Pro Ala Ala Asp Ile  Ala His Pro Ser Phe  Gln Arg Leu 
    1535                 1540                 1545             


Phe Val  Glu Thr Gly Trp Asp  Asp Ala Arg Gln Val  Leu Trp Ala 
    1550                 1555                 1560             


Gln Arg  Arg Pro Glu Ser Asp  Asp Gln Pro Asp Val  Tyr Ala Ala 
    1565                 1570                 1575             


Phe His  Leu Val Ala Asp Glu  Glu Ala Pro Ala Pro  Val Glu Trp 
    1580                 1585                 1590             


Asp Ser  His Arg Ala Arg Phe  Val Gly Arg Gly Gly  Ser Leu Ala 
    1595                 1600                 1605             


Ala Pro  Arg Gly Leu Trp Arg  Arg Leu Arg Gly Glu  Gly Val Ala 
    1610                 1615                 1620             


Asp Pro  Ala Ala Ile Leu Arg  Thr Ala Val Thr Leu  Ala Pro Gly 
    1625                 1630                 1635             


Glu Lys  Arg Ala Leu Tyr Val  Ile Thr Ala Leu Gly  Glu Ala Arg 
    1640                 1645                 1650             


Asp Glu  Val Val Glu Thr Ala  Phe Glu Met Arg Gln  Pro Ser Ala 
    1655                 1660                 1665             


Arg Ser  Arg Ala Ala Gln Leu  Ala Trp Met Arg Ala  Gln Ile Asp 
    1670                 1675                 1680             


Leu Arg  Gln Leu His Leu Ser  Pro Asp Asp Val Glu  Asp Ala Met 
    1685                 1690                 1695             


Glu Leu  Leu Ser Arg Phe Leu  Ser Arg His Ala Phe  Ser Pro Glu 
    1700                 1705                 1710             


Arg Arg  Ala Ala Ile Leu Gln  Asn Glu Leu Gly Gln  Ser Gly Leu 
    1715                 1720                 1725             


Trp Ala  His Gly Ile Ser Gly  Asp Arg Pro Ile Val  Ala Val Arg 
    1730                 1735                 1740             


Leu Ala  Ser Ala Ala Glu Val  Pro Phe Val Ala Lys  Leu Ala Arg 
    1745                 1750                 1755             


Leu Thr  Gln Tyr Leu Ala His  Met Gly Phe Ala Ser  Asp Leu Val 
    1760                 1765                 1770             


Val Ile  Asp Glu Thr Ile Ser  Ser Tyr Arg Asp Glu  Met Arg Asp 
    1775                 1780                 1785             


Arg Ile  Arg Ala Glu Met Ala  Arg Arg Gly Val His  Asp Ala Ala 
    1790                 1795                 1800             


Thr Leu  Ala Val Val Lys Ala  Asp Gln Leu Ser Ser  Ala Glu Arg 
    1805                 1810                 1815             


Ala Leu  Met Glu Ser Val Ala  Val Ala Thr Leu Arg  Ala Gly Gly 
    1820                 1825                 1830             


Pro Ser  Val Gly Ala Gln Leu  Thr Gly Gly Arg Val  Arg Arg Glu 
    1835                 1840                 1845             


Glu Ser  Ala Arg Leu Ala Ser  Asp Arg Leu Glu Pro  Glu Pro Lys 
    1850                 1855                 1860             


Arg Ala  Pro Arg Asp Ala Gly  Gln Val Glu Gly Glu  Phe Ala Asn 
    1865                 1870                 1875             


Gly Tyr  Gly Ala Phe Val Asp  Asp Gly Arg Ala Tyr  Arg Met Arg 
    1880                 1885                 1890             


Val Thr  Arg Ala Lys Arg Pro  Pro Arg Pro Trp Ser  Asn Val Leu 
    1895                 1900                 1905             


Ala Asn  Pro Asn Phe Gly Ala  Leu Val Thr Glu Leu  Gly Thr Gly 
    1910                 1915                 1920             


Tyr Thr  Trp Trp Arg Asn Ser  Arg Glu Phe Lys Leu  Thr Pro Trp 
    1925                 1930                 1935             


His Asn  Asp Ala Ala Phe Asp  Pro Pro Gly Glu Ala  Val Tyr Ile 
    1940                 1945                 1950             


Ala Asp  Leu Asp Arg Gly Ile  Ile Ala Ser Ala Thr  Pro Ser Pro 
    1955                 1960                 1965             


Ala Gly  Asp Glu Arg Thr Tyr  Asp Val Thr His Arg  Pro Gly Val 
    1970                 1975                 1980             


Thr Thr  Phe Glu Ser Asp Val  Glu Gly Val Arg Val  Thr Leu His 
    1985                 1990                 1995             


Val Phe  Val Asp Ser Ala Glu  Pro Ala Lys Trp Met  Arg Val Arg 
    2000                 2005                 2010             


Leu Arg  Asn Gln Ser Gly Glu  Glu Arg Arg Ile Arg  Val Ala Pro 
    2015                 2020                 2025             


Tyr Ala  Glu Trp Val Leu Gly  Val Asp Pro Phe Ser  Asn Thr Pro 
    2030                 2035                 2040             


Leu Val  Val Val Arg Lys Met  Gly Glu Ala Asp Ala  Ile Ala Ala 
    2045                 2050                 2055             


Glu Asn  Arg Tyr Gln Glu Ala  Phe Arg Gly Ala Leu  Gly Phe Leu 
    2060                 2065                 2070             


Ala Val  Gly Gly Ala Gly Arg  Thr Thr Gly Trp Leu  Gly Asp Lys 
    2075                 2080                 2085             


Thr Arg  Phe Leu Gly Asp Gly  Ser Tyr Ala Arg Pro  Asp Ala Leu 
    2090                 2095                 2100             


Leu Glu  Asp Ala Trp Arg Gly  Gly Asp Gly Pro Thr  Pro Thr Pro 
    2105                 2110                 2115             


Cys Ala  Val Leu Ala Arg Asp  Leu Asp Leu Gly Pro  His Glu Glu 
    2120                 2125                 2130             


Ala Glu  Val Val Ile Leu Leu  Gly Ala Ala Pro Asp  Glu His Glu 
    2135                 2140                 2145             


Ala Ala  Arg Leu Ala Arg Leu  Ala Asp Pro Ala Ala  Ala Asp Arg 
    2150                 2155                 2160             


Ala Leu  Arg Glu Val Thr Arg  Phe Trp Asp Asp Leu  Leu Gly Arg 
    2165                 2170                 2175             


Val Gln  Ile Arg Thr Pro Asp  Arg Ala Phe Asp Ile  Leu Met Asn 
    2180                 2185                 2190             


Gly Trp  Leu Val Tyr Gln Ala  Leu Ala Cys Arg Leu  Trp Ala Arg 
    2195                 2200                 2205             


Thr Ala  Phe Tyr Gln Ala Gly  Gly Ala Phe Gly Phe  Arg Asp Gln 
    2210                 2215                 2220             


Leu Gln  Asp Ala Leu Ala Leu  Ile His Ala Arg Pro  Asp Ile Leu 
    2225                 2230                 2235             


Arg Asp  Gln Ile Leu Arg Ala  Ala Arg His Gln Tyr  Val Glu Gly 
    2240                 2245                 2250             


Asp Val  Gln His Trp Trp His  Glu Glu Leu Gly Lys  Gly Ile Arg 
    2255                 2260                 2265             


Thr Arg  Phe Ser Asp Asp Leu  Leu Trp Leu Pro Tyr  Ala Val Ser 
    2270                 2275                 2280             


Arg Tyr  Leu Glu Ala Thr Gly  Asp Ala Ala Leu Leu  Asp Glu Arg 
    2285                 2290                 2295             


Ala Pro  Tyr Leu Val Ser Ala  Pro Leu Gly Asp Gly  Glu Leu Glu 
    2300                 2305                 2310             


Arg Tyr  Glu Asp Ser Val Trp  Ser Gln Glu Glu Gly  Thr Leu Ala 
    2315                 2320                 2325             


Glu His  Val Ala Arg Ala Val  Glu Arg Ala Leu His  Phe Gly Asp 
    2330                 2335                 2340             


His Gly  Leu Pro Leu Ile Gly  Ile Gly Asp Trp Asn  Asp Gly Leu 
    2345                 2350                 2355             


Ser Arg  Val Gly Ala Lys Gly  Arg Gly Glu Ser Val  Trp Leu Ala 
    2360                 2365                 2370             


Trp Phe  Leu Ala Asp Val Val  Arg Arg Val Ala Glu  Ile Asp His 
    2375                 2380                 2385             


Pro Glu  Phe Ala Gln His Arg  Ala Arg Trp Leu Ala  Met Arg Glu 
    2390                 2395                 2400             


Arg Val  Leu Ala Ala Ala Asn  Glu Ser Ala Trp Asp  Gly Gln Trp 
    2405                 2410                 2415             


Tyr Arg  Arg Ala Ile Thr Asp  Asp Gly Leu Trp Leu  Gly Ser Ala 
    2420                 2425                 2430             


Ala Ser  Pro Ala Cys Arg Val  Asp Ala Ile Ala Gln  Ser Trp Ala 
    2435                 2440                 2445             


Val Ile  Ser Gly Gly Ala Pro  Pro Asp Arg Ala Val  Arg Ala Met 
    2450                 2455                 2460             


Glu Ser  Phe Asp Arg Glu Leu  Val Asp Arg Arg Leu  Gly Val Ala 
    2465                 2470                 2475             


His Leu  Leu Gln Pro Ala Phe  Arg Asp Leu Arg Pro  Ser Pro Gly 
    2480                 2485                 2490             


Tyr Ile  Gln Gly Tyr Pro Pro  Gly Ile Arg Glu Asn  Gly Gly Gln 
    2495                 2500                 2505             


Tyr Thr  His Gly Val Ile Trp  Ser Val Ile Ala Trp  Thr Arg Leu 
    2510                 2515                 2520             


Gly Arg  Ala Asp Glu Ala Tyr  Glu Leu Phe Ser Met  Leu Asn Pro 
    2525                 2530                 2535             


Ile His  His Ala Asp Thr Pro  Arg Glu Val Glu Arg  Tyr Gly Asn 
    2540                 2545                 2550             


Glu Pro  Tyr Val Met Ser Ala  Asp Val Tyr Thr Ala  Glu Pro Asn 
    2555                 2560                 2565             


Val Gly  Gln Gly Gly Trp Ser  Trp Tyr Thr Gly Ala  Ala Ser Trp 
    2570                 2575                 2580             


Met Tyr  Gln Ala Gly Leu Glu  Ala Ile Leu Gly Ile  Arg Arg His 
    2585                 2590                 2595             


Gly Thr  Arg Leu Leu Val Glu  Pro Cys Val Pro Ala  His Trp Pro 
    2600                 2605                 2610             


Gly Phe  Glu Val Ala Tyr Arg  Tyr Gly Ser Thr Leu  Tyr Arg Ile 
    2615                 2620                 2625             


Arg Val  Glu Arg Ala Pro Gln  Gly Ala Glu Ala Arg  Asp Ser Ala 
    2630                 2635                 2640             


Leu Thr  Val Glu Gly Val Ala  Pro Ala Glu Ile Asp  Leu Val Asp 
    2645                 2650                 2655             


Asp Gly  Gln Glu His His Val  Val Val Trp Leu Ala  Ala Glu Gly 
    2660                 2665                 2670             


Ala Glu  Val Leu Ser Asp Val  Gln Thr Val Ala Ala  Arg Pro Arg 
    2675                 2680                 2685             


Glu Gly  Ala Arg Arg Tyr Arg  Met Ser Ser Gly Ala  Arg Ala Phe 
    2690                 2695                 2700             


Pro Ala  Ser Ala Ala Tyr Arg  Lys Arg Asp Pro Gln  Pro 
    2705                 2710                 2715     


<210>  217
<211>  2716
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:202 and encoded by SEQ ID NO:212

<400>  217

Met Ala Phe Asp Thr Glu Leu Glu Arg Arg Ala His Ala Ile Ala Leu 
1               5                   10                  15      


Thr Gln Asp Ile Ser Ser Thr Arg Gly Gly Gly Ser Asp Leu Trp Pro 
            20                  25                  30          


Ile Leu Arg Arg Lys Ala Ala Arg Val Arg Asn Leu Ala Thr Arg Leu 
        35                  40                  45              


Glu Arg Glu Pro Ala Ala Cys Ser Glu Pro Ala His Glu Trp Leu Ile 
    50                  55                  60                  


Asp His Ala Ala Tyr Leu Glu Leu Gln Ala Met Leu Ala Glu Arg Leu 
65                  70                  75                  80  


Trp Pro Asn Ala Val Val Arg Lys Leu Pro Arg Met Ala Glu Thr Gly 
                85                  90                  95      


Glu Pro Arg Val Val Thr Leu Ala Ala Ala Tyr Leu Asp Ala Thr Arg 
            100                 105                 110         


Gly His Val Glu Ala Glu Thr Leu Ile Arg Phe Val Glu Ala Tyr Gln 
        115                 120                 125             


Asp Val Gln Val Leu Thr Thr His Glu Cys His Gln Leu Ala Asn Gly 
    130                 135                 140                 


Leu Arg Val Ala Ile Leu Thr Arg Leu Ala Glu Ala Ser Asp Glu Ile 
145                 150                 155                 160 


Gln His Arg Tyr Glu Thr Cys Arg Ala Val Gly Arg Leu Leu Asp Glu 
                165                 170                 175     


Ile Glu Arg Gly Asp Gly Pro Val Ala Val Arg Arg Ala Ile Asp Arg 
            180                 185                 190         


Phe Ser Lys Gly Arg Gly Leu Gly Ala Val Glu Val Val His Leu Val 
        195                 200                 205             


His His Leu Ser Glu Trp Glu Pro Asp Ser Gln Glu Leu Arg Glu Trp 
    210                 215                 220                 


Leu Ala Ala His Val Ala Asn Ser Ser Glu Ser Ile Glu Arg Leu Thr 
225                 230                 235                 240 


Thr Tyr Glu Ala Glu Trp His Ala Glu Ile Gln Val Leu Ile Gly Asn 
                245                 250                 255     


Leu Val Gln Ser Leu His Ala Leu Glu Arg Met Ser Trp Gln Pro Ile 
            260                 265                 270         


Ala Ser Arg Ile Ser Arg Val Glu Ser Cys Leu Arg Gln Glu Pro Thr 
        275                 280                 285             


Gly Asp Tyr Leu Arg Leu Asp Pro Thr Ser Gln Asn Val Leu Thr Gln 
    290                 295                 300                 


Gln Val Ser Trp Leu Ser Glu Ala Phe Arg Leu Pro Glu Ala Met Ile 
305                 310                 315                 320 


Ala Glu Thr Ala Val Ser Leu Ala Arg Glu Ala Trp Glu Lys Ala Gly 
                325                 330                 335     


Ser Pro Thr Ala Ser Ser Asp Leu Pro Arg Glu Ala Phe Val Ala Tyr 
            340                 345                 350         


Tyr Leu Cys Asp Pro Asp Gly Met His Ala Leu His Arg Ser Leu Lys 
        355                 360                 365             


Glu Arg Ala Lys Pro Arg Ser Val Pro Gln Ile Ala Leu Arg Arg Arg 
    370                 375                 380                 


Pro Leu Arg Ser Tyr Leu Leu Gly Val Ala Phe Leu Phe Ala Ala Ile 
385                 390                 395                 400 


Leu Trp Ala Val Leu Gly Gly Phe Thr Gly Gly Phe Arg Ala Pro Leu 
                405                 410                 415     


Gly Ala Thr Leu Ala Leu Ala Val Leu Leu Ala Leu Pro Val Ser Glu 
            420                 425                 430         


Trp Val Ile Ser Leu Val His Glu Gly Ile Arg Arg Ala Val Arg Pro 
        435                 440                 445             


Val Pro Leu Leu Arg Leu Asp Phe Ser Glu Gly Ile Pro Glu Asp Ala 
    450                 455                 460                 


Arg Thr Leu Ile Val Leu Pro Val Ile Trp Ala Ser Glu Ala Asp Val 
465                 470                 475                 480 


Asp Glu Ala Phe Asp Lys Ile Glu Leu His His Leu Thr Asn Arg Gly 
                485                 490                 495     


Ala His Leu Tyr Phe Ala Val Leu Ser Asp Leu Arg Asp Ala Asp Ala 
            500                 505                 510         


Pro His Leu Pro Glu Asp Glu Pro Leu Leu Ala Arg Ala Arg Ala Arg 
        515                 520                 525             


Leu Glu Ala Leu Arg His Lys Tyr Gly Ala Ala Arg Phe Phe Trp Phe 
    530                 535                 540                 


His Arg Asp Arg Val Leu Asn Arg Ala Asp Gly Val Tyr Met Gly Trp 
545                 550                 555                 560 


Glu Arg Lys Arg Gly Lys Leu Val Glu Phe Val Glu Leu Leu Arg Gly 
                565                 570                 575     


Lys Arg Asp Thr Thr Phe Arg Val Lys Asp Gly Asp Leu Ala Val Leu 
            580                 585                 590         


Pro Thr Ile Arg Tyr Val Phe Thr Ala Asp Leu Asp Thr Glu Leu Pro 
        595                 600                 605             


Ile Gly Thr Val Gln Arg Leu Val Gly Thr Met His Leu Pro Tyr Asn 
    610                 615                 620                 


Arg Pro Arg Leu Asn Ala Arg Gly Thr Arg Val Asp Gln Gly Tyr Gly 
625                 630                 635                 640 


Val Leu Gln Pro Ala Val Ala Val Ser Pro Arg Ser Thr Gln Ala Ser 
                645                 650                 655     


Arg Phe Ala Arg Leu Trp Ser Gly Glu Thr Gly Val Asp Pro Tyr Ala 
            660                 665                 670         


Phe Ala Ile Ser Asn Pro Tyr Gln Asp Trp Phe Gly Arg Gly Leu Phe 
        675                 680                 685             


Val Gly Lys Gly Leu Ile His Val Asp Ala Phe His Thr Val Leu Cys 
    690                 695                 700                 


Asp Arg Ile Pro Asp Asn Arg Val Leu Ser His Asp Ile Leu Glu Gly 
705                 710                 715                 720 


Gly Phe Leu Arg Ala Gly Leu Val Ala Asp Val Glu Val Val Glu Ser 
                725                 730                 735     


Gln Pro Ala Thr Leu Arg Ala Tyr Met Arg Arg Ala His Arg Trp Val 
            740                 745                 750         


Arg Gly Asp Trp Gln Leu Thr Tyr Trp Leu Arg Arg Val Cys Arg Asp 
        755                 760                 765             


Arg Arg Gly Glu Thr Gln Pro Val Asp Leu Cys Gly Phe Thr Arg Trp 
    770                 775                 780                 


Asn Ile Val Asp His Val Arg His Ser Leu Val Asn Pro Ala Leu Val 
785                 790                 795                 800 


Leu Leu Met Gly Ser Gly Met Ser Gly Leu Leu Pro Gly Pro Ala Tyr 
                805                 810                 815     


Ala Tyr Gly Ala Val Leu Leu Ile Thr Val Phe Leu Pro Phe Leu Arg 
            820                 825                 830         


Gln Leu Glu Ser Ile Arg Pro Gly Glu Trp Asp Trp Arg Ser Ala Ala 
        835                 840                 845             


Thr Ala Leu Gly Gln Ser Leu Val Met Leu Val Thr Leu Pro Phe Met 
    850                 855                 860                 


Ala Val Val Glu Ala Asp Ala Ser Leu Arg Ala Leu Tyr Arg Met Leu 
865                 870                 875                 880 


Val Ser Arg Arg Arg Leu Leu Glu Trp Ile Pro Ser Ser His Ala Asp 
                885                 890                 895     


Arg Ser Asp Gly Ser Pro Ala Pro Leu Leu Tyr Glu Pro Ala Gly Tyr 
            900                 905                 910         


Ala Val Ala Leu Ala Cys Ser Val Pro Gly Leu Phe Gly Thr Trp Glu 
        915                 920                 925             


Gln Ala Leu Ser Ser Thr Leu Ala Leu Ala Val Trp Leu Pro Ala His 
    930                 935                 940                 


Ala Val Ala Arg Phe Leu Ala Lys Pro Ala Gly Glu Ala Arg Val Ala 
945                 950                 955                 960 


Ala Pro Asp Pro Ala Leu Ser Ala His Leu Arg Glu Val Ala Thr Ala 
                965                 970                 975     


Met Trp Arg Phe Tyr Glu Arg Tyr Val Gly Glu Glu Asp His His Leu 
            980                 985                 990         


Pro Pro Asp Asn Val Gln Phe Glu  Pro Val Glu Arg Ile  Ala His Arg 
        995                 1000                 1005             


Thr Ser  Pro Thr Asn Ile Gly  Leu Tyr Leu Leu Cys  Val Ala Ala 
    1010                 1015                 1020             


Ala Ala  Asp Leu Glu Ile Ile  Pro Lys Glu Gly Ala  Ile Ala Arg 
    1025                 1030                 1035             


Leu Glu  Arg Thr Leu Ala Thr  Leu Thr Ser Leu Asp  Arg Trp His 
    1040                 1045                 1050             


Gly His  Leu Phe Asn Trp Tyr  Asp Thr Arg Thr Leu  Arg Pro Leu 
    1055                 1060                 1065             


Ala Pro  Arg Tyr Val Ser Thr  Val Asp Ser Gly Asn  Leu Val Cys 
    1070                 1075                 1080             


Ala Met  Leu Ala Leu Gly Gln  Ala Leu Arg Glu Trp  Ala Ala Ser 
    1085                 1090                 1095             


Asp Ala  Asp Ile Ala Pro Arg  Ala Arg Arg Leu Ala  Asp Ala Met 
    1100                 1105                 1110             


Glu Gly  Phe Ala Arg Glu Ile  Asp Phe Arg Pro Leu  Tyr Arg Pro 
    1115                 1120                 1125             


Asp Leu  Arg Leu Phe Ser Leu  Gly Phe His Ala Asp  Arg Asn Glu 
    1130                 1135                 1140             


Leu Glu  Asn Ile Val Tyr Asp  Leu Leu Ala Ser Glu  Ala Arg Gln 
    1145                 1150                 1155             


Ala Ser  Phe Ile Ala Ile Ala  Ser Gly Gln Val Pro  Ala Ser His 
    1160                 1165                 1170             


Trp Phe  Ala Leu Ser Arg Thr  Met Thr Arg Ala Gly  Arg Tyr Gln 
    1175                 1180                 1185             


Pro Leu  Leu Ser Trp Ser Gly  Thr Met Phe Glu Tyr  Leu Met Pro 
    1190                 1195                 1200             


Ala Leu  Leu Met Arg His Leu  Pro His Thr Leu Trp  Glu Glu Thr 
    1205                 1210                 1215             


Tyr Arg  Gly Val Val Trp Arg  Gln Ile Ala Tyr Ala  Arg Glu Arg 
    1220                 1225                 1230             


Gly Val  Pro Phe Gly Ile Ser  Glu Ser Gly Phe Tyr  Ala Phe Asp 
    1235                 1240                 1245             


Arg Asp  Leu Asn Tyr Gln Tyr  Arg Ala Phe Gly Val  Pro Gly Leu 
    1250                 1255                 1260             


Gly Leu  Asp Arg Gly Leu Glu  Gln His Leu Val Val  Ala Pro Tyr 
    1265                 1270                 1275             


Ala Thr  Met Leu Ala Leu Pro  Phe Ala Pro Glu Gln  Val Ala Glu 
    1280                 1285                 1290             


Ala Leu  Arg Gln Leu Arg Glu  Leu Gly Ala Leu Gly  Pro Tyr Gly 
    1295                 1300                 1305             


Tyr Tyr  Glu Ala Val Asp Phe  Thr Ala Ser Arg Leu  Pro Pro Gly 
    1310                 1315                 1320             


Asp Arg  Tyr Lys Val Val Gln  Ser Phe Met Ala His  His Gln Gly 
    1325                 1330                 1335             


Met Ala  Phe Ile Ala Ile Ala  Asn Tyr Leu Asn Arg  Asn Leu Trp 
    1340                 1345                 1350             


Val Glu  Arg Phe His Arg Leu  Pro Leu Val Arg Ala  Ala Glu Tyr 
    1355                 1360                 1365             


Met Leu  Tyr Glu Arg Met Pro  Lys Arg Pro Ala Leu  Leu Leu Lys 
    1370                 1375                 1380             


Pro Val  His Ala Ala His Ala  Pro Asn Phe Asp Arg  Pro Val Tyr 
    1385                 1390                 1395             


Ala Arg  Arg Arg Ser Gly Asp  Asp Val Ala Trp Asn  Ala Val Ser 
    1400                 1405                 1410             


Asn Gly  Ser Leu Thr Ser Phe  Ala Asp Ala Arg Gly  Glu Gly Gly 
    1415                 1420                 1425             


Ile Ala  Trp Arg Gly Ile Ala  Val Thr Arg Tyr Arg  Pro Asp Arg 
    1430                 1435                 1440             


His Leu  Pro Tyr Arg Gly Pro  Val Met Tyr Val Arg  Asp Val Asp 
    1445                 1450                 1455             


Arg Gly  Gly Val Phe Arg Thr  Thr Leu His Gly Gly  Gly Gly His 
    1460                 1465                 1470             


Val Glu  Ala Glu Phe Arg Pro  Asp Lys Ser Ser Trp  Lys Arg Val 
    1475                 1480                 1485             


Val Asp  Gly Ile Glu Ser Glu  Trp Ser Val Leu Val  Ala Pro Asp 
    1490                 1495                 1500             


Arg Asp  Val Glu Ile Arg Thr  Leu Val Leu Gln Asn  Leu Gly Glu 
    1505                 1510                 1515             


Asp Val  Arg Arg Leu Glu Val  Thr Tyr Phe Ala Glu  Leu Ala Leu 
    1520                 1525                 1530             


Ala Lys  Pro Ala Ala Asp Ile  Ala His Pro Ser Phe  Gln Arg Leu 
    1535                 1540                 1545             


Phe Val  Glu Thr Gly Trp Asp  Asp Ala Arg Gln Val  Leu Trp Ala 
    1550                 1555                 1560             


Gln Arg  Arg Pro Glu Ser Asp  Asp Gln Pro Asp Val  Tyr Ala Ala 
    1565                 1570                 1575             


Phe His  Leu Val Ala Asp Glu  Glu Ala Pro Ala Pro  Val Glu Trp 
    1580                 1585                 1590             


Asp Ser  His Arg Ala Arg Phe  Val Gly Arg Gly Gly  Ser Leu Ala 
    1595                 1600                 1605             


Ala Pro  Arg Gly Leu Trp Arg  Arg Leu Arg Gly Glu  Gly Val Ala 
    1610                 1615                 1620             


Asp Pro  Ala Ala Ile Leu Arg  Thr Ala Val Thr Leu  Ala Pro Gly 
    1625                 1630                 1635             


Glu Lys  Arg Ala Leu Tyr Val  Ile Thr Ala Leu Gly  Glu Ala Arg 
    1640                 1645                 1650             


Asp Glu  Val Val Glu Thr Ala  Phe Glu Met Arg Gln  Pro Ser Ala 
    1655                 1660                 1665             


Arg Ser  Arg Ala Ala Gln Leu  Ala Trp Met Arg Ala  Gln Ile Asp 
    1670                 1675                 1680             


Leu Arg  Gln Leu His Leu Ser  Pro Asp Asp Val Glu  Asp Ala Met 
    1685                 1690                 1695             


Glu Leu  Leu Ser Arg Phe Leu  Ser Arg His Ala Phe  Ser Pro Glu 
    1700                 1705                 1710             


Arg Arg  Ala Ala Ile Leu Gln  Asn Glu Leu Gly Gln  Ser Gly Leu 
    1715                 1720                 1725             


Trp Ala  His Gly Ile Ser Gly  Asp Arg Pro Ile Val  Ala Val Arg 
    1730                 1735                 1740             


Leu Ala  Ser Ala Ala Glu Val  Pro Phe Val Ala Lys  Leu Ala Arg 
    1745                 1750                 1755             


Leu Thr  Gln Tyr Leu Ala His  Met Gly Phe Ala Ser  Asp Leu Val 
    1760                 1765                 1770             


Val Ile  Asp Glu Thr Ile Ser  Ser Tyr Arg Asp Glu  Met Arg Asp 
    1775                 1780                 1785             


Arg Ile  Arg Ala Glu Met Ala  Arg Arg Gly Val His  Asp Ala Ala 
    1790                 1795                 1800             


Thr Leu  Ala Val Val Lys Ala  Asp Gln Leu Ser Ser  Ala Glu Arg 
    1805                 1810                 1815             


Ala Leu  Met Glu Ser Val Ala  Val Ala Thr Leu Arg  Ala Gly Gly 
    1820                 1825                 1830             


Pro Ser  Val Gly Ala Gln Leu  Thr Gly Gly Arg Val  Arg Arg Glu 
    1835                 1840                 1845             


Glu Ser  Ala Arg Leu Ala Ser  Asp Arg Leu Glu Pro  Glu Pro Lys 
    1850                 1855                 1860             


Arg Ala  Pro Arg Asp Ala Gly  Gln Val Glu Gly Glu  Phe Ala Asn 
    1865                 1870                 1875             


Gly Tyr  Gly Ala Phe Val Asp  Asp Gly Arg Ala Tyr  Arg Met Arg 
    1880                 1885                 1890             


Val Thr  Arg Ala Lys Arg Pro  Pro Arg Pro Trp Ser  Asn Val Leu 
    1895                 1900                 1905             


Ala Asn  Pro Asn Phe Gly Ala  Leu Val Thr Glu Leu  Gly Thr Gly 
    1910                 1915                 1920             


Tyr Thr  Trp Trp Arg Asn Ser  Arg Glu Phe Lys Leu  Thr Pro Trp 
    1925                 1930                 1935             


His Asn  Asp Ala Ala Phe Asp  Pro Pro Gly Glu Ala  Val Tyr Ile 
    1940                 1945                 1950             


Ala Asp  Leu Asp Arg Gly Ile  Ile Ala Ser Ala Thr  Pro Ser Pro 
    1955                 1960                 1965             


Ala Gly  Asp Glu Arg Thr Tyr  Asp Val Thr His Arg  Pro Gly Val 
    1970                 1975                 1980             


Thr Thr  Phe Glu Ser Asp Val  Glu Gly Val Arg Val  Thr Leu His 
    1985                 1990                 1995             


Val Phe  Val Asp Ser Ala Glu  Pro Ala Lys Trp Met  Arg Val Arg 
    2000                 2005                 2010             


Leu Arg  Asn Gln Ser Gly Glu  Glu Arg Arg Ile Arg  Val Ala Pro 
    2015                 2020                 2025             


Tyr Ala  Glu Trp Val Leu Gly  Val Asp Pro Phe Ser  Asn Thr Pro 
    2030                 2035                 2040             


Leu Val  Val Val Arg Lys Met  Gly Glu Ala Asp Ala  Ile Ala Ala 
    2045                 2050                 2055             


Glu Asn  Arg Tyr Gln Glu Ala  Phe Arg Gly Ala Leu  Gly Phe Leu 
    2060                 2065                 2070             


Ala Val  Gly Gly Ala Gly Arg  Thr Thr Gly Trp Leu  Gly Asp Lys 
    2075                 2080                 2085             


Thr Arg  Phe Leu Gly Asp Gly  Ser Tyr Ala Arg Pro  Asp Ala Leu 
    2090                 2095                 2100             


Leu Glu  Asp Ala Trp Arg Gly  Gly Asp Gly Pro Thr  Pro Thr Pro 
    2105                 2110                 2115             


Cys Ala  Val Leu Ala Arg Asp  Leu Asp Leu Gly Pro  His Glu Glu 
    2120                 2125                 2130             


Ala Glu  Val Val Ile Leu Leu  Gly Ala Ala Pro Asp  Glu His Glu 
    2135                 2140                 2145             


Ala Ala  Arg Leu Ala Arg Leu  Ala Asp Pro Ala Ala  Ala Asp Arg 
    2150                 2155                 2160             


Ala Leu  Arg Glu Val Thr Arg  Phe Trp Asp Asp Leu  Leu Gly Arg 
    2165                 2170                 2175             


Val Gln  Ile Arg Thr Pro Asp  Arg Ala Phe Asp Ile  Leu Met Asn 
    2180                 2185                 2190             


Gly Trp  Leu Val Tyr Gln Ala  Leu Ala Cys Arg Leu  Trp Ala Arg 
    2195                 2200                 2205             


Thr Ala  Phe Tyr Gln Ala Gly  Gly Ala Phe Gly Phe  Arg Asp Gln 
    2210                 2215                 2220             


Leu Gln  Asp Ala Leu Ala Leu  Ile His Ala Arg Pro  Asp Ile Leu 
    2225                 2230                 2235             


Arg Asp  Gln Ile Leu Arg Ala  Ala Arg His Gln Tyr  Val Glu Gly 
    2240                 2245                 2250             


Asp Val  Gln His Trp Trp His  Glu Glu Leu Gly Lys  Gly Ile Arg 
    2255                 2260                 2265             


Thr Arg  Phe Ser Asp Asp Leu  Leu Trp Leu Pro Tyr  Ala Val Ser 
    2270                 2275                 2280             


Arg Tyr  Leu Glu Ala Thr Gly  Asp Ala Ala Leu Leu  Asp Glu Arg 
    2285                 2290                 2295             


Ala Pro  Tyr Leu Val Ser Ala  Pro Leu Gly Asp Gly  Glu Leu Glu 
    2300                 2305                 2310             


Arg Tyr  Glu Asp Ser Val Trp  Ser Gln Glu Glu Gly  Thr Leu Ala 
    2315                 2320                 2325             


Glu His  Val Ala Arg Ala Val  Glu Arg Ala Leu His  Phe Gly Asp 
    2330                 2335                 2340             


His Gly  Leu Pro Leu Ile Gly  Ile Gly Asp Trp Asn  Asp Gly Leu 
    2345                 2350                 2355             


Ser Arg  Val Gly Ala Lys Gly  Arg Gly Glu Ser Val  Trp Leu Ala 
    2360                 2365                 2370             


Trp Phe  Leu Ala Asp Val Val  Arg Arg Val Ala Glu  Ile Asp His 
    2375                 2380                 2385             


Pro Glu  Phe Ala Gln His Arg  Ala Arg Trp Leu Ala  Met Arg Glu 
    2390                 2395                 2400             


Arg Val  Leu Ala Ala Ala Asn  Glu Ser Ala Trp Asp  Gly Gln Trp 
    2405                 2410                 2415             


Tyr Arg  Arg Ala Ile Thr Asp  Asp Gly Leu Trp Leu  Gly Ser Ala 
    2420                 2425                 2430             


Ala Ser  Pro Ala Cys Arg Val  Asp Ala Ile Ala Gln  Ser Trp Ala 
    2435                 2440                 2445             


Val Ile  Ser Gly Gly Ala Pro  Pro Asp Arg Ala Val  Arg Ala Met 
    2450                 2455                 2460             


Glu Ser  Phe Asp Arg Glu Leu  Val Asp Arg Arg Leu  Gly Val Ala 
    2465                 2470                 2475             


His Leu  Leu Gln Pro Ala Phe  Arg Asp Leu Arg Pro  Ser Pro Gly 
    2480                 2485                 2490             


Tyr Ile  Gln Gly Tyr Pro Pro  Gly Ile Arg Glu Asn  Gly Gly Gln 
    2495                 2500                 2505             


Tyr Thr  His Gly Val Ile Trp  Ser Val Ile Ala Trp  Thr Arg Leu 
    2510                 2515                 2520             


Gly Arg  Ala Asp Glu Ala Tyr  Glu Leu Phe Ser Met  Leu Asn Pro 
    2525                 2530                 2535             


Ile His  His Ala Asp Thr Pro  Arg Glu Val Glu Arg  Tyr Gly Asn 
    2540                 2545                 2550             


Glu Pro  Tyr Val Met Ser Ala  Asp Val Tyr Thr Ala  Glu Pro Asn 
    2555                 2560                 2565             


Val Gly  Gln Gly Gly Trp Ser  Trp Tyr Thr Gly Ala  Ala Ser Trp 
    2570                 2575                 2580             


Met Tyr  Gln Ala Gly Leu Glu  Ala Ile Leu Gly Ile  Arg Arg His 
    2585                 2590                 2595             


Gly Thr  Arg Leu Leu Val Glu  Pro Cys Val Pro Ala  His Trp Pro 
    2600                 2605                 2610             


Gly Phe  Glu Val Ala Tyr Arg  Tyr Gly Ser Thr Leu  Tyr Arg Ile 
    2615                 2620                 2625             


Arg Val  Glu Arg Ala Pro Gln  Gly Ala Glu Ala Arg  Asp Ser Ala 
    2630                 2635                 2640             


Leu Thr  Val Glu Gly Val Ala  Pro Ala Glu Ile Asp  Leu Val Asp 
    2645                 2650                 2655             


Asp Gly  Gln Glu His His Val  Val Val Trp Leu Ala  Ala Glu Gly 
    2660                 2665                 2670             


Ala Glu  Val Leu Ser Asp Val  Gln Thr Val Ala Ala  Arg Pro Arg 
    2675                 2680                 2685             


Glu Gly  Ala Arg Arg Tyr Arg  Met Ser Ser Gly Ala  Arg Ala Phe 
    2690                 2695                 2700             


Pro Ala  Ser Ala Ala Tyr Arg  Lys Arg Asp Pro Gln  Pro 
    2705                 2710                 2715     


<210>  218
<211>  2376
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  218
atgagatggg ctgcgaagcg gccaagatgc tcgtccatat gctgcagaag ggcgagatgc     60

catcaggcac gctgttgccg ccgcaactcg tcgtgcgcga gacggcctga gcacttcaac    120

tgggggagag gcatcatgca tggatgggtc atcaaagaaa acgacctgtt ttggtacgga    180

gacgcagagg gtctgagcgc gcacggagtt gaaaacgttt ccggtcacgg gctttacacc    240

agagacacgc gcgtgctctc agcgctcgtt tggcgcatcg agcccgacgt gtgggtggca    300

ttggacgccc ttgcggagtc cggctcggaa tcggtgtacc gttacaccaa tcgccctccg    360

cgggccgatc acgagcctcc gcgcgagagc ctgctggtgg agcgccggca gcgcgtggac    420

ggacattgct ttcaagaaag cggtatcgtg cgcaattttg gcgatcgcgc cgtgcgcctc    480

gcggtgatct acgaggtcgc ggcggacttc gcggacatgt tcgaagttcg ggggttccag    540

gtcgaggcgc ccgcgagagc gattcgttca cgggtgtccg gaaacgtttg cggtttttct    600

tattcgtcct ccgacgggcg gacttgggag acgcgcgtcc agctcgctgc gcatccgagt    660

cacgcgggtg agatgacgcc cgttcggtgg accgagtcgg ccggcgtggg ccgggcggag    720

ttgctgatca cggtggacgc cggaggtgcc gcggagtgga cgctcaccgt tcgaccggag    780

gtgcgcggag gcacggaatt ccccgccgca ggagaaacag ggatcggctt gtctgtttcc    840

gaaaacgttt ccagtcatcc gcgtggaaac gccgccgagg gcttgaggtc caggccagca    900

cggaacgctg aagatgacgc gtcctcagcg cggggatggt tgaatggcgc gccgacggtt    960

tccgggcatg aagcattcgg ccgctggtac gagcagggca tgcgggacat tcgcatgctc   1020

cagtccgact ttgggtttgg gccgtttctc gtggcggggg taccgtggta cgcagtcccg   1080

ttcggaaggg acagcttgat tgccgcccgg cagatccttt ccgcggcgcc ggaggtcgcg   1140

cgaggcactc tcgccacgct ggcccatttc cagggcgaac gtgtggacac ggagcgggat   1200

gagcagcctg ggaagattct gcacgaactc agggacggcg aactcgcgcg cagcggcaag   1260

gttccattcc gcccgtacta cggcagcatc gacgccacgc cgctctttct catcctcttg   1320

gcggactact ggcgcttcac aggcgacacg ccgttcctca cgcggatgct tccccatgcg   1380

gagcgggcgc ttgcgtggat ggcggattac ggcgatcgcg acggagacgg gttcatcgag   1440

tattggcgcg aggccgaggg cgggatcgcc aatcagggat ggaaggattc gggggactcg   1500

atggtccacg ccgacggcag cttggcgcaa ggccccatcg cgctcgcgga ggtccaggcg   1560

tacgcgtaca tggcgtacgt ggcttggcgt gagatttacc gcgagctcgg cgaacccgaa   1620

gaagcggagc ggctggcgag actcgcggat gggctgcgat ctcgcttcct gcagcacttc   1680

tggctggagg agaggaatga aatcgcaatg gcgcttgacg gaaacaagcg accgctttgc   1740

gtggcctcgt ccaacatggg ccaagtgctg tggagcgaca tcctgccgtc cgaagtggcc   1800

gagcgcgtcg caaagcgcct gctgcagccc gacctgttct cgggatttgg cattcgcacg   1860

ctctctgcga aggagctccg ctacaatccg atgagctatc acaacggttc ggtctggccg   1920

cacgatacca gcctcgtctt cgccgggctg gtgaggcacg gggcctggga ggaagccgag   1980

cagatcttcg aggggctcat gagggcgcag gcgcaatttc cgcaccatcg gctgccggag   2040

ttgttctgcg ggttttcccg tgaggaaagc cctcggcctg tcccgtaccc ggtttcatgc   2100

tcgccccagg cgtgggcggc ggcggttccg gccattgtgc tggagaacct gctgggtctc   2160

cgcccggacg cgcctcgggg agaattgacg attttcccgc gattgccggc gagcatgcag   2220

gagctgaagg tgcacgggct acggctcggc cgcgggaagc tgtcggtcga gatcgcgcgt   2280

cgggacggat gtgtcttggt cgacgtggtg gaaaacacca cgggcttgcg ggtggacgtg   2340

atggacggcg cgaaggaggt gatgtccgcc agctga                             2376


<210>  219
<211>  791
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  219

Met Arg Trp Ala Ala Lys Arg Pro Arg Cys Ser Ser Ile Cys Cys Arg 
1               5                   10                  15      


Arg Ala Arg Cys His Gln Ala Arg Cys Cys Arg Arg Asn Ser Ser Cys 
            20                  25                  30          


Ala Arg Arg Pro Glu His Phe Asn Trp Gly Arg Gly Ile Met His Gly 
        35                  40                  45              


Trp Val Ile Lys Glu Asn Asp Leu Phe Trp Tyr Gly Asp Ala Glu Gly 
    50                  55                  60                  


Leu Ser Ala His Gly Val Glu Asn Val Ser Gly His Gly Leu Tyr Thr 
65                  70                  75                  80  


Arg Asp Thr Arg Val Leu Ser Ala Leu Val Trp Arg Ile Glu Pro Asp 
                85                  90                  95      


Val Trp Val Ala Leu Asp Ala Leu Ala Glu Ser Gly Ser Glu Ser Val 
            100                 105                 110         


Tyr Arg Tyr Thr Asn Arg Pro Pro Arg Ala Asp His Glu Pro Pro Arg 
        115                 120                 125             


Glu Ser Leu Leu Val Glu Arg Arg Gln Arg Val Asp Gly His Cys Phe 
    130                 135                 140                 


Gln Glu Ser Gly Ile Val Arg Asn Phe Gly Asp Arg Ala Val Arg Leu 
145                 150                 155                 160 


Ala Val Ile Tyr Glu Val Ala Ala Asp Phe Ala Asp Met Phe Glu Val 
                165                 170                 175     


Arg Gly Phe Gln Val Glu Ala Pro Ala Arg Ala Ile Arg Ser Arg Val 
            180                 185                 190         


Ser Gly Asn Val Cys Gly Phe Ser Tyr Ser Ser Ser Asp Gly Arg Thr 
        195                 200                 205             


Trp Glu Thr Arg Val Gln Leu Ala Ala His Pro Ser His Ala Gly Glu 
    210                 215                 220                 


Met Thr Pro Val Arg Trp Thr Glu Ser Ala Gly Val Gly Arg Ala Glu 
225                 230                 235                 240 


Leu Leu Ile Thr Val Asp Ala Gly Gly Ala Ala Glu Trp Thr Leu Thr 
                245                 250                 255     


Val Arg Pro Glu Val Arg Gly Gly Thr Glu Phe Pro Ala Ala Gly Glu 
            260                 265                 270         


Thr Gly Ile Gly Leu Ser Val Ser Glu Asn Val Ser Ser His Pro Arg 
        275                 280                 285             


Gly Asn Ala Ala Glu Gly Leu Arg Ser Arg Pro Ala Arg Asn Ala Glu 
    290                 295                 300                 


Asp Asp Ala Ser Ser Ala Arg Gly Trp Leu Asn Gly Ala Pro Thr Val 
305                 310                 315                 320 


Ser Gly His Glu Ala Phe Gly Arg Trp Tyr Glu Gln Gly Met Arg Asp 
                325                 330                 335     


Ile Arg Met Leu Gln Ser Asp Phe Gly Phe Gly Pro Phe Leu Val Ala 
            340                 345                 350         


Gly Val Pro Trp Tyr Ala Val Pro Phe Gly Arg Asp Ser Leu Ile Ala 
        355                 360                 365             


Ala Arg Gln Ile Leu Ser Ala Ala Pro Glu Val Ala Arg Gly Thr Leu 
    370                 375                 380                 


Ala Thr Leu Ala His Phe Gln Gly Glu Arg Val Asp Thr Glu Arg Asp 
385                 390                 395                 400 


Glu Gln Pro Gly Lys Ile Leu His Glu Leu Arg Asp Gly Glu Leu Ala 
                405                 410                 415     


Arg Ser Gly Lys Val Pro Phe Arg Pro Tyr Tyr Gly Ser Ile Asp Ala 
            420                 425                 430         


Thr Pro Leu Phe Leu Ile Leu Leu Ala Asp Tyr Trp Arg Phe Thr Gly 
        435                 440                 445             


Asp Thr Pro Phe Leu Thr Arg Met Leu Pro His Ala Glu Arg Ala Leu 
    450                 455                 460                 


Ala Trp Met Ala Asp Tyr Gly Asp Arg Asp Gly Asp Gly Phe Ile Glu 
465                 470                 475                 480 


Tyr Trp Arg Glu Ala Glu Gly Gly Ile Ala Asn Gln Gly Trp Lys Asp 
                485                 490                 495     


Ser Gly Asp Ser Met Val His Ala Asp Gly Ser Leu Ala Gln Gly Pro 
            500                 505                 510         


Ile Ala Leu Ala Glu Val Gln Ala Tyr Ala Tyr Met Ala Tyr Val Ala 
        515                 520                 525             


Trp Arg Glu Ile Tyr Arg Glu Leu Gly Glu Pro Glu Glu Ala Glu Arg 
    530                 535                 540                 


Leu Ala Arg Leu Ala Asp Gly Leu Arg Ser Arg Phe Leu Gln His Phe 
545                 550                 555                 560 


Trp Leu Glu Glu Arg Asn Glu Ile Ala Met Ala Leu Asp Gly Asn Lys 
                565                 570                 575     


Arg Pro Leu Cys Val Ala Ser Ser Asn Met Gly Gln Val Leu Trp Ser 
            580                 585                 590         


Asp Ile Leu Pro Ser Glu Val Ala Glu Arg Val Ala Lys Arg Leu Leu 
        595                 600                 605             


Gln Pro Asp Leu Phe Ser Gly Phe Gly Ile Arg Thr Leu Ser Ala Lys 
    610                 615                 620                 


Glu Leu Arg Tyr Asn Pro Met Ser Tyr His Asn Gly Ser Val Trp Pro 
625                 630                 635                 640 


His Asp Thr Ser Leu Val Phe Ala Gly Leu Val Arg His Gly Ala Trp 
                645                 650                 655     


Glu Glu Ala Glu Gln Ile Phe Glu Gly Leu Met Arg Ala Gln Ala Gln 
            660                 665                 670         


Phe Pro His His Arg Leu Pro Glu Leu Phe Cys Gly Phe Ser Arg Glu 
        675                 680                 685             


Glu Ser Pro Arg Pro Val Pro Tyr Pro Val Ser Cys Ser Pro Gln Ala 
    690                 695                 700                 


Trp Ala Ala Ala Val Pro Ala Ile Val Leu Glu Asn Leu Leu Gly Leu 
705                 710                 715                 720 


Arg Pro Asp Ala Pro Arg Gly Glu Leu Thr Ile Phe Pro Arg Leu Pro 
                725                 730                 735     


Ala Ser Met Gln Glu Leu Lys Val His Gly Leu Arg Leu Gly Arg Gly 
            740                 745                 750         


Lys Leu Ser Val Glu Ile Ala Arg Arg Asp Gly Cys Val Leu Val Asp 
        755                 760                 765             


Val Val Glu Asn Thr Thr Gly Leu Arg Val Asp Val Met Asp Gly Ala 
    770                 775                 780                 


Lys Glu Val Met Ser Ala Ser 
785                 790     


<210>  220
<211>  702
<212>  PRT
<213>  Bacillus halodurans 

<400>  220

Met Asp Tyr Arg Val Ile Lys Glu Asn Asp Val Phe Leu Leu Thr Asp 
1               5                   10                  15      


Glu Lys Gly Asn Ile Pro Glu Asn His Ser Tyr Gly Ala Gly Leu Tyr 
            20                  25                  30          


Thr Lys Asp Thr Arg Phe Leu Ser Lys Leu Asp Leu Arg Ile Asn Gly 
        35                  40                  45              


Glu Glu Pro Ile Leu Leu Asn Ser Glu Ala Gln Asn Ala Tyr Met Ala 
    50                  55                  60                  


Ser Ile Leu Leu Thr Asn Pro His Met Glu Lys Asp Gly Asp Leu Ile 
65                  70                  75                  80  


Leu Trp Arg Glu Ser Val Glu Leu Glu Arg Lys Arg Phe Ile Ala Asn 
                85                  90                  95      


Asp Val Val Tyr Glu Lys Ile Arg Ala Lys Asn Tyr Phe Pro Lys Pro 
            100                 105                 110         


Val Thr Phe Thr Val Asn Leu His Phe Asp Cys Asp Phe Gln Asp Met 
        115                 120                 125             


Phe Val Val Arg Gly Phe Gln His Gly Asp Val Gly Lys Arg Thr Gly 
    130                 135                 140                 


Gln Ser Val Thr Asp Asn Glu Met Arg Phe His Tyr Glu Gly Ala Asp 
145                 150                 155                 160 


Glu Ile Gln Arg Thr Thr Leu Ile Ser Trp Asp Gln Thr Ala Gln Thr 
                165                 170                 175     


Val Ser Asp Ala Gly Tyr Leu Asp Phe Thr Cys Thr Leu Gly His Glu 
            180                 185                 190         


Glu Ser Gln Glu Ile Val Leu Thr Ile Ala Pro Ile Leu Asn Gly Glu 
        195                 200                 205             


Glu Pro Thr Ile Leu Pro Phe Asp Val Ala Leu Glu Gln Val Lys Glu 
    210                 215                 220                 


Ser Tyr Arg Ala Trp Asn Glu Gly Val Thr Lys Val Lys Thr Asp His 
225                 230                 235                 240 


Pro Arg Leu Gln Arg Leu Leu Asp Gln Gly Ile Thr Asp Leu Arg Val 
                245                 250                 255     


Leu Leu Thr Asp Leu Gly Tyr Gly Ser Phe Pro Val Ala Gly Leu Pro 
            260                 265                 270         


Trp Phe Ala Val Pro Phe Gly Arg Asp Ser Leu Ile Ala Ala Leu Gln 
        275                 280                 285             


Met Leu Pro Phe Gln Pro Glu Val Ala Lys Gly Thr Ile Arg Thr Met 
    290                 295                 300                 


Ala Ala Tyr Gln Gly Thr Lys Arg Asp Pro Trp Arg Asp Glu Glu Pro 
305                 310                 315                 320 


Gly Lys Ile Met His Glu Leu Arg Ser Gly Glu Leu Ala Asn Thr Lys 
                325                 330                 335     


Gln Val Pro Phe Ser Pro Tyr Tyr Gly Thr Ile Asp Ala Thr Pro Leu 
            340                 345                 350         


Tyr Leu Met Leu Ile Val Glu Tyr Val Lys Trp Thr Gly Asp Thr Thr 
        355                 360                 365             


Leu Leu Glu Glu Leu Asp Ser Ser Ile Glu Ala Ala Leu Arg Trp Ile 
    370                 375                 380                 


Asp Lys Phe Gly Asp Arg Asp Gly Asp Gly Phe Val Glu Tyr Tyr Gln 
385                 390                 395                 400 


Glu Ala Ala Lys Gly Ile Ala Asn Gln Gly Trp Lys Asp Ser Gly Asp 
                405                 410                 415     


Ser Ile Val His Arg Asn Gly Asp Tyr Ala Lys Thr Pro Ile Ala Leu 
            420                 425                 430         


Ala Glu Val Gln Gly Tyr Val Tyr Gln Ala Lys Thr Gly Leu Ala Glu 
        435                 440                 445             


Leu Tyr Glu Gly Leu Asn Arg Ile Asp Leu Ala Arg Lys Leu Ser Glu 
    450                 455                 460                 


Glu Ala Gln Gln Leu Ser Glu Arg Phe Glu Gln Ala Phe Trp Met Glu 
465                 470                 475                 480 


Asp Val Gly Phe Tyr Ala Ile Ala Leu Asp Gln Glu Lys Lys Gln Val 
                485                 490                 495     


Gly Thr Ile Thr Ser Asn Pro Gly His Leu Leu Phe Ser Asn Met Leu 
            500                 505                 510         


Ser Lys Glu Arg Ala Lys Gln Val Ser Asp Gln Leu Val Ser Asn Lys 
        515                 520                 525             


Leu Phe Ser Gly Tyr Gly Ile Arg Thr Met Ala Glu Gly Glu Ala Gly 
    530                 535                 540                 


Tyr Asn Pro Met Ser Tyr His Asp Gly Ser Val Trp Pro His Asp Asn 
545                 550                 555                 560 


Ser Ile Ile Leu Leu Gly Met Gly Arg Leu Gly His His Glu Gln Ala 
                565                 570                 575     


Asn Arg Val Ile Asn Gly Leu Ile Asp Ser Ala Ser Ser Phe Glu Tyr 
            580                 585                 590         


Asp Arg Leu Pro Glu Leu Phe Cys Gly Tyr Glu Lys Gly Glu Arg Ala 
        595                 600                 605             


Val Lys Tyr Pro Val Ala Cys Ser Pro Gln Ala Trp Ala Ala Gly Thr 
    610                 615                 620                 


Pro Leu Val Phe Ile Gln Thr Ile Leu Gly Leu Glu Pro Asn Val Pro 
625                 630                 635                 640 


Lys Gly Lys Ile Phe Phe Ser Pro Ser Leu Pro Asp Gly Met Lys Glu 
                645                 650                 655     


Leu Thr Val Glu Asn Met Lys Val Gly Lys Gly Thr Ile Ser Leu Thr 
            660                 665                 670         


Leu Lys Lys Lys Gly Gln Gln Thr Gln Leu Asp Val Met Ser Asn Thr 
        675                 680                 685             


Thr Gly Leu Asp Val Gln Cys Ala Ser Val Ile Ser Gln Gly 
    690                 695                 700         


<210>  221
<211>  712
<212>  PRT
<213>  Bacillus NRRL B-14911

<400>  221

Met His Phe Asn Arg Asn Val Ser Glu Arg Gln Glu Asp Leu Met Asp 
1               5                   10                  15      


Tyr Arg Val Ile Lys Glu Asn Asp Leu Phe Leu Leu Thr Asp Ser Lys 
            20                  25                  30          


Gly Asn Ile Pro Glu Asn His Ser Tyr Gly Leu Gly Leu Tyr Thr Lys 
        35                  40                  45              


Asp Thr Arg Phe Leu Ser Arg Leu Asp Ile Arg Ile Asn Gly Glu Glu 
    50                  55                  60                  


Pro Ile Leu Leu Ser Ser Asp Ala Asp Glu Asn Tyr Met Ala Lys Ile 
65                  70                  75                  80  


Leu Leu Thr Asn Pro His Met Glu Lys Asp Gly Glu Leu Ile Leu Trp 
                85                  90                  95      


Arg Glu Ser Val Glu Ile Glu Arg Val Arg Phe Ile Tyr Glu Glu Val 
            100                 105                 110         


Leu Tyr Glu Thr Val Lys Leu Lys Asn Tyr Phe Pro Lys Glu Ile Glu 
        115                 120                 125             


Phe Asn Phe Ser Leu Arg Ala Asp Ala Asp Phe Ala Asp Met Phe Ile 
    130                 135                 140                 


Val Arg Gly Phe Gln Asn Gly Asp Ile Gly Lys Arg Thr Gly Gln Thr 
145                 150                 155                 160 


Cys Gly Arg Gln Asn Leu Ser Phe His Tyr Glu Gly Ala Asp Gly Leu 
                165                 170                 175     


Glu Arg Arg Thr Arg Ile Ser Trp Asp Lys Glu Gly Ala Glu Val Glu 
            180                 185                 190         


Ser Ser Gly Glu Val Ser Phe Arg Phe Lys Leu Gln His Leu Glu Glu 
        195                 200                 205             


Glu Ala Val Thr Phe Val Ile Glu Pro Gln Thr Gly Gln Glu Ala Thr 
    210                 215                 220                 


Lys Glu Ile Gln Pro Ala Glu Lys Ala Lys Glu Leu Leu Arg Asp Ser 
225                 230                 235                 240 


Tyr Gln Lys Trp Asn Asp Glu Thr Thr Lys Val Glu Thr Asp Tyr Glu 
                245                 250                 255     


Pro Leu Gln Arg Leu Val Asp Arg Gly Ile Asp Asp Leu Arg Val Leu 
            260                 265                 270         


Leu Thr Asp Leu Gly His Gly Glu Phe Pro Val Ala Gly Leu Pro Trp 
        275                 280                 285             


Phe Gly Val Pro Phe Gly Arg Asp Ser Leu Ile Ala Ala Leu Gln Met 
    290                 295                 300                 


Leu Ala Phe Cys Pro Glu Val Ala Lys Gly Thr Leu Arg Thr Met Ala 
305                 310                 315                 320 


Ser Arg Gln Gly Asp Lys Leu Asp Pro Trp Arg Asp Glu Gln Pro Gly 
                325                 330                 335     


Lys Ile Met His Glu Leu Arg Phe Gly Glu Leu Ala Asn Thr Gly Gln 
            340                 345                 350         


Ile Pro Phe Thr Pro Tyr Tyr Gly Thr Ile Asp Ala Thr Pro Leu Phe 
        355                 360                 365             


Leu Met Leu Leu Thr Glu Tyr Val Lys Trp Thr Gly Asp Ile Thr Ile 
    370                 375                 380                 


Ala Asp Glu Leu Gly Glu Asn Ile Glu Ala Ala Leu Asn Trp Ile Asp 
385                 390                 395                 400 


Glu His Gly Asp Arg Asp Gly Asp Leu Phe Val Glu Tyr His Gln Glu 
                405                 410                 415     


Ser Ser Lys Gly Ile Ala Asn Gln Gly Trp Lys Asp Ser Gly Asp Ser 
            420                 425                 430         


Ile Val His Arg Asn Gly Glu Tyr Ala Lys Thr Pro Ile Ala Leu Ser 
        435                 440                 445             


Glu Val Gln Gly Tyr Val Tyr Gln Ala Lys Arg Gly Ile Ala Ser Ile 
    450                 455                 460                 


Tyr Glu Gln Leu Gly Lys Glu Ala Glu Ala Val Lys Leu Arg Asn Gln 
465                 470                 475                 480 


Ala Glu Lys Leu Lys Glu Lys Phe Asn Glu Ala Phe Trp Met Glu Asp 
                485                 490                 495     


Gln Gln Phe Tyr Ala Ile Ala Leu Asp Glu Lys Lys Gln Gln Val Gly 
            500                 505                 510         


Thr Ile Thr Ser Asn Pro Gly His Thr Leu Phe Ser Gly Ile Val Glu 
        515                 520                 525             


Gly Glu Arg Ala Asp Ala Val Ser Asp Met Leu Val Ser Pro Lys Met 
    530                 535                 540                 


Tyr Ser Gly Phe Gly Val Arg Thr Met Gly Glu Gly Glu Ala Gly Tyr 
545                 550                 555                 560 


Asn Pro Met Ser Tyr His Asp Gly Ser Ile Trp Pro His Asp Asn Ser 
                565                 570                 575     


Met Ile Leu Leu Gly Met Ser Lys Leu Gly Lys Thr Ala His Ala Ser 
            580                 585                 590         


Gln Val Met Glu Gly Leu Ile Lys Ala Ser Ala Ser Phe Glu Tyr Asp 
        595                 600                 605             


Arg Leu Pro Glu Leu Phe Cys Gly Tyr Asp Ala Ser Arg Gly Lys Ala 
    610                 615                 620                 


Val Lys Tyr Pro Val Ala Cys Ser Pro Gln Ala Trp Ala Ala Gly Thr 
625                 630                 635                 640 


Pro Leu Val Phe Ile Gln Ala Leu Leu Gly Leu Phe Pro Asp Ser Leu 
                645                 650                 655     


Lys Glu Glu Val Arg Met Ser Pro Ser Leu Leu Glu Gly Met Asn Lys 
            660                 665                 670         


Leu Thr Val Arg Asn Ile Lys Ile Gly Lys Gly Leu Leu Ser Leu Gln 
        675                 680                 685             


Ala Ala Arg Thr Glu Ser Gly Val Lys Leu Glu Ile Thr Glu Asn Thr 
    690                 695                 700                 


Thr Gly Tyr Gln Ile Asn Ile His 
705                 710         


<210>  222
<211>  761
<212>  PRT
<213>  Nostoc muscorum

<400>  222

Met Thr Pro Asp Thr Leu Thr Asn Pro Asp Lys Ile Phe Leu Asp Gly 
1               5                   10                  15      


Lys Thr Phe Ile Pro Ala Asp Gln Leu Pro Ile Pro Glu Trp Pro Cys 
            20                  25                  30          


Val Val Ser Glu Arg Pro Gln Pro Thr Leu Thr Val Lys Asp Asp Asp 
        35                  40                  45              


Leu Phe Leu Val Thr Asp Thr Ile Gly Asn Ile Ser Gly Cys Ser Leu 
    50                  55                  60                  


Ser Glu Gly Asn Pro Ser Met Gly Leu Phe Cys Cys Asp Thr Arg Phe 
65                  70                  75                  80  


Leu Asn Arg Leu Glu Leu Gln Ile Asp Gly Arg Ser Pro Val Leu Leu 
                85                  90                  95      


Ser Ser Thr Ala Glu Lys Gly Phe Ala Leu Ser Val Leu Cys Thr Asn 
            100                 105                 110         


Pro Arg Ile Asp Glu Arg Met Lys Ala Asp Ser Val Ser Ile Arg Arg 
        115                 120                 125             


Glu Leu Val Leu Asn Gly Ala Leu Phe Glu Glu Ile Glu Val Ala Asn 
    130                 135                 140                 


Tyr Ser Thr Thr Thr Val Ala Phe Glu Leu Ser Ile Ser Phe Asp Ala 
145                 150                 155                 160 


Asp Phe Val Asp Leu Phe Glu Val Arg Gly Tyr Asn Arg Asp Lys Arg 
                165                 170                 175     


Gly Lys Leu Leu Arg Leu Val Glu Pro Ile Ala Glu Asp Gly Leu Val 
            180                 185                 190         


Asp Gly Asp Gly Ala Ala Val His Thr Gln His Phe Ala His Lys Glu 
        195                 200                 205             


Gln Ser Leu Thr Leu Ala Tyr Gln Gly Leu Asp Gly Ser Val Met Glu 
    210                 215                 220                 


Ser Arg Ile Gln Phe Gln His Arg Gln Pro Asp Asp Phe Lys Gly Tyr 
225                 230                 235                 240 


Thr Ala Ile Trp Arg Leu Glu Leu Pro Ser His Ser Thr Gln Lys Leu 
                245                 250                 255     


Gly Tyr Arg Val Asn Met Phe Thr Asn Asn Asn Ser Ser Ser Arg Val 
            260                 265                 270         


Ser Ala Ala Val Thr Leu Val Gln Ala Lys Ala Ser Glu Met Met Glu 
        275                 280                 285             


Glu Gln Asn Trp Val Gln Lys Ile Thr Asn Ile Arg Ala Asp Lys Ser 
    290                 295                 300                 


Ile Phe Asn Leu Val Ile Glu Arg Ala Glu Gln Asp Met Tyr Leu Leu 
305                 310                 315                 320 


Arg Gln Ser Phe Asp Lys Tyr Lys Thr Val Ser Ala Gly Val Pro Trp 
                325                 330                 335     


Phe Ser Ala Leu Phe Gly Arg Asp Ser Leu Ile Thr Ala Ser Gln Thr 
            340                 345                 350         


Leu Met Leu Asn Pro Glu Ile Ala Lys Glu Thr Leu Met Leu Leu Ala 
        355                 360                 365             


Ala Tyr Gln Gly Lys His Glu Asp Glu Trp Arg Glu Glu Ala Pro Gly 
    370                 375                 380                 


Lys Ile Leu His Glu Leu Arg Leu Gly Glu Met Ala Arg Cys Gln Glu 
385                 390                 395                 400 


Ile Pro His Thr Pro Tyr Tyr Gly Thr Val Asp Ala Thr Pro Leu Trp 
                405                 410                 415     


Leu Met Leu Tyr Ser Glu Tyr Tyr Ser Trp Thr His Asp Arg Glu Thr 
            420                 425                 430         


Leu Glu Gln Leu Trp Pro His Ala Leu Ala Ala Met Asp Trp Ile Asp 
        435                 440                 445             


Arg Asn Met Gln Pro Ser Gly Tyr Leu Thr Tyr His Arg Lys Ser Lys 
    450                 455                 460                 


Arg Gly Leu Asp Asn Gln Gly Trp Lys Asp Ser Gly Asp Cys Ile Val 
465                 470                 475                 480 


Asp Arg Lys Gly Asp Leu Ala Asn Gly Ser Ile Ala Leu Ser Glu Val 
                485                 490                 495     


Gln Ala Tyr Val Tyr Ala Ala Lys Thr Arg Leu Ala Glu Ile Ala Arg 
            500                 505                 510         


Met Lys Lys Arg Leu Asp Leu Phe Glu Arg Trp Gln Glu Glu Ala Arg 
        515                 520                 525             


Ser Leu Lys Glu Arg Phe Asn Gln Asp Phe Trp Ile Glu Asp Gln Asp 
    530                 535                 540                 


Phe Cys Ala Leu Ala Leu Asp Gly Ala Gly Lys Gln Val Asp Ser Ile 
545                 550                 555                 560 


Thr Ser Asn Pro Gly His Cys Leu Leu Leu Gly Ile Phe Thr Pro Glu 
                565                 570                 575     


Arg Ala Tyr Ser Val Ala Glu Arg Leu Arg Ala Pro Asp Met Phe Asn 
            580                 585                 590         


Gly Trp Gly Ile Arg Thr Leu Ser Ser Leu Ser Pro Ala Tyr Asn Pro 
        595                 600                 605             


Met Gly Tyr His Ile Gly Ser Val Trp Pro His Asp Asn Ser Leu Ile 
    610                 615                 620                 


Ala Met Gly Leu Arg Ser Leu Gly Leu Ile Asp Gln Ala Leu Glu Ile 
625                 630                 635                 640 


Phe Gln Gly Leu Leu Asp Met Thr Ser Gln Gln Pro Tyr Gln Arg Pro 
                645                 650                 655     


Pro Glu Leu Phe Cys Gly Tyr Glu Arg Asn Gly Asp Arg Ser Pro Val 
            660                 665                 670         


Gln Tyr Pro Val Ala Cys Thr Pro Gln Ala Trp Ala Thr Gly Ser Ile 
        675                 680                 685             


Phe Gln Leu Ile Gln Met Ile Val Asn Leu Val Pro Asp Ala Pro Asn 
    690                 695                 700                 


Asn Cys Leu Arg Ile Ile Asp Pro Ala Leu Pro Glu Ser Ile Ser Arg 
705                 710                 715                 720 


Leu Ser Leu His Asn Leu Gln Val Gly Thr Thr Val Leu Asp Leu Glu 
                725                 730                 735     


Phe Glu Arg Ser Gly Gly Thr Thr Ala Cys Arg Val Ala Arg Lys Arg 
            740                 745                 750         


Gly Asn Leu Arg Val Val Ile Glu Ala 
        755                 760     


<210>  223
<211>  712
<212>  PRT
<213>  Thermobifida fusca

<400>  223

Met Lys Val Trp Asn Ile Ser Thr Gly Thr Ser Gly Glu Gly Ser Gly 
1               5                   10                  15      


Ala Val Thr Ile Val Glu Gly Thr Ser Phe Ala Ile Ser Ala Gly Asp 
            20                  25                  30          


Gly Ser Met Leu Pro Asp His Pro His Gly Val Phe Tyr Asp Asp Ile 
        35                  40                  45              


Arg Ile Val Ser Lys Trp Glu Phe Ser Val Asp Asn Gln Ala Leu Glu 
    50                  55                  60                  


Pro Leu Thr Val Ile Val His Asp Gln Pro Tyr Gln Ala Val Phe Leu 
65                  70                  75                  80  


Ala Arg Ala Arg Arg Gly Gly Arg Thr Ser Asn Thr Ile Phe Val Glu 
                85                  90                  95      


Arg Glu Arg Arg Val Gly Thr Gly Met Arg Glu Asp Ile Thr Leu Arg 
            100                 105                 110         


Asn Met Gly Arg Glu Pro Ala Ala Cys Thr Val Thr Leu Val Val Asp 
        115                 120                 125             


Ala Asp Phe Ala Asp Leu Phe Glu Val Lys Lys Gly Glu Pro Gln Asn 
    130                 135                 140                 


Asp Gly His Tyr Val Phe Arg Ser Glu Gly Thr Arg Ile Ile Val Glu 
145                 150                 155                 160 


Arg Trp Trp Arg Gly Met Gln Arg Gly Val Ile Ile Gln Ala Asp Asp 
                165                 170                 175     


Ala Thr Ser Val Ala His Asp Arg Ile Thr Phe Arg Ala Val Val Pro 
            180                 185                 190         


Glu Arg Gly Gln Trp Ser Thr Thr Val Leu Val Arg Pro Val Val Asp 
        195                 200                 205             


Gly Glu Asp Leu Arg Pro Arg Phe Pro Lys Glu Gln Pro Val Asp Glu 
    210                 215                 220                 


Ser Glu Pro Ala Arg Arg Leu Arg Glu Trp Gln Ser Asn Thr Pro Val 
225                 230                 235                 240 


Val Ser Thr Asp Asn Asp Ala Leu Leu Ala Val Leu Arg Arg Ser Gln 
                245                 250                 255     


Gln Asp Val Gly Ala Leu Arg Ile Phe Asp Ser Arg His Pro Gln Arg 
            260                 265                 270         


Ser Ile Val Ala Ala Gly Ala Pro Trp Phe Met Ala Leu Phe Gly Arg 
        275                 280                 285             


Asp Ser Leu Leu Thr Ala Tyr Met Ala Leu Pro Leu Asp Pro Ser Leu 
    290                 295                 300                 


Ala Leu Gly Thr Leu Gln Thr Leu Ala Asp Arg Gln Gly Val Glu Glu 
305                 310                 315                 320 


Asn Ile Leu Thr Glu Glu Glu Pro Gly Arg Ile Leu His Glu Ser Arg 
                325                 330                 335     


Leu Gly Lys Glu Ser Gly Leu Trp Leu Gly Asp Gly Thr Val Tyr Tyr 
            340                 345                 350         


Gly Thr Ala Asp Ala Thr Pro Leu Phe Val Ile Leu Leu Gly Glu Leu 
        355                 360                 365             


Ser Arg Trp Gly Ala Asp Pro Ala Glu Ile Glu Lys Leu Leu Pro His 
    370                 375                 380                 


Ala Asp Arg Ala Leu Glu Trp Ile Glu Arg Tyr Gly Asp Arg Asp Gly 
385                 390                 395                 400 


Asp Gly Phe Val Glu Tyr Arg Arg Arg Thr Asp Gln Gly Leu Val Asn 
                405                 410                 415     


Gln Gly Trp Lys Asp Ser Trp Asp Gly Ile Asn Phe Ala Asp Gly Arg 
            420                 425                 430         


Ile Ala Glu Ala Pro Ile Ala Leu Cys Glu Val Gln Gly Tyr Val Tyr 
        435                 440                 445             


Ala Ala Tyr Leu Ala Arg Ala Tyr Leu Ala His Gln Thr Gly Asp Asp 
    450                 455                 460                 


Gln Arg Ala Arg Tyr Trp Thr Glu Arg Ala Ala Asp Leu Lys Lys Ala 
465                 470                 475                 480 


Phe Asn Glu Arg Phe Trp Gln Pro Glu Leu Gly Tyr Tyr Ala Val Ala 
                485                 490                 495     


Leu Asp His Glu Lys Lys Pro Val Asp Ala Cys Thr Ser Asn Met Gly 
            500                 505                 510         


His Cys Leu Trp Ser Gly Ile Val Asp Glu Asp Lys Ala Pro Tyr Val 
        515                 520                 525             


Ala Asp Arg Leu Leu Ser Pro Thr Met Phe Ser Gly Trp Gly Ile Arg 
    530                 535                 540                 


Thr Leu Ala Thr Asp Met Gly Ala Tyr Asp Pro Val Ser Tyr His Asn 
545                 550                 555                 560 


Gly Ser Val Trp Pro His Asp Asn Ala Ile Ile Ala Ser Gly Leu Met 
                565                 570                 575     


Arg Tyr Gly Phe Thr Glu His Ala Gln Arg Val Ala Thr Ala Leu Phe 
            580                 585                 590         


Glu Ala Ala Glu His Phe Gly Tyr Arg Leu Pro Glu Leu Phe Cys Gly 
        595                 600                 605             


Phe Asp Arg Thr Asp Tyr Pro Lys Pro Val Pro Tyr Pro Thr Ser Cys 
    610                 615                 620                 


Ser Pro Gln Ala Trp Ala Ala Ala Thr Pro Ile His Leu Leu Arg Thr 
625                 630                 635                 640 


Leu Leu Arg Phe Asp Pro Trp Val Pro Arg Gly Glu Leu Arg Leu Ala 
                645                 650                 655     


Pro Ser Leu Pro Pro Gly Tyr Thr Arg Leu Arg Ile Glu Arg Leu Pro 
            660                 665                 670         


Ile Ala Gly Ser Gln Leu Thr Val Asp Val Thr Gly Asp Glu Val Ser 
        675                 680                 685             


Val Glu Gly Leu Pro Glu Gly Leu Arg Leu Val Ser Glu Pro Arg Glu 
    690                 695                 700                 


Leu Asp Ser Leu Ser Leu Val Glu 
705                 710         


<210>  224
<211>  660
<212>  PRT
<213>  Mesorhizobium loti

<400>  224

Met Leu Ser Glu Phe Arg Leu Thr Val Gly Gly Arg Ser Thr Ser Leu 
1               5                   10                  15      


Leu Gly Ala Ser Leu Ser Gln Asp Asn Val Leu Phe Thr Thr Asn Leu 
            20                  25                  30          


Thr Asn Leu Pro Ile Glu Ser Ala Ala Gly Arg Gln Ile Pro Gln Gly 
        35                  40                  45              


Ala Met His Ile Glu Arg Val Arg Leu Leu Trp Glu Glu Arg Leu Tyr 
    50                  55                  60                  


Glu Arg Ile Thr Leu Ser Asn Tyr Ser Arg Glu His Ser Thr Ile Leu 
65                  70                  75                  80  


Leu Ser Leu Arg Phe Ala Ala Asp Phe Arg Asp Met Phe Glu Val Arg 
                85                  90                  95      


Gly Ser Thr Arg Leu Lys Arg Gly Thr Ala Asp Thr Ala Glu Ile Ala 
            100                 105                 110         


Gly Asn Ala Val Val Leu Arg Tyr Glu Gly Leu Asp Lys Val Val Arg 
        115                 120                 125             


Thr Ser Ala Ile Ser Phe Ser Gln Thr Pro Asp Gln Leu Thr Ser Glu 
    130                 135                 140                 


Arg Ala Asp Phe Val Ile Ala Val Thr Lys Arg Ser Ser Gln Thr Leu 
145                 150                 155                 160 


Tyr Val Glu Val Gly Asn Ala Thr Asp Asp Arg Pro Glu Ser Arg Arg 
                165                 170                 175     


Phe Arg Ala Ala Ala Ala Arg Ala Arg Phe Gly Met Arg Ala Lys Arg 
            180                 185                 190         


Arg His Gly Ala Thr Leu His Ser Ser Gly Arg Val Phe Asn Asp Trp 
        195                 200                 205             


Met Glu Arg Ala Arg Ala Asp Val Ala Leu Leu Thr Thr Glu Leu Ala 
    210                 215                 220                 


Thr Gly Pro Tyr Pro Tyr Ala Gly Ile Pro Trp Phe Ser Thr Ala Phe 
225                 230                 235                 240 


Gly Arg Asp Gly Val Ile Ser Ala Leu Gln Met Leu Trp Leu Asn Pro 
                245                 250                 255     


Gly Leu Ala Arg Gly Val Leu Ala Phe Leu Ala Gln His Gln Ala Thr 
            260                 265                 270         


Glu Thr Ser Pro Phe Ser Asp Ser Glu Pro Gly Lys Ile Met His Glu 
        275                 280                 285             


Thr Arg Lys Gly Glu Met Val Ala Leu Ser Glu Leu Pro Phe Gly Arg 
    290                 295                 300                 


Tyr Tyr Gly Gly Val Asp Thr Thr Pro Leu Tyr Ile His Leu Ala Cys 
305                 310                 315                 320 


Ala Tyr Ala Asp Arg Thr Gly Asp Thr Ala Phe Ile Asp Thr Leu Trp 
                325                 330                 335     


Pro Ser Leu Cys Ala Ala Ala Glu Trp Ile Glu Thr Ala Ser Arg Ser 
            340                 345                 350         


Thr Gly Phe Leu Thr Tyr Gln Arg Ala Ala Glu Ser Gly Leu Ala Asn 
        355                 360                 365             


Gln Gly Trp Lys Asp Ser Phe Asp Ser Val Phe His Ala Asp Gly Arg 
    370                 375                 380                 


Ile Pro Lys Gly Pro Ile Ala Leu Val Glu Val Gln Gly Tyr Val Phe 
385                 390                 395                 400 


Ala Ala Phe Gln Gly Leu Ala Lys Leu Ala Arg Leu Arg Gly Glu Ala 
                405                 410                 415     


Glu Arg Ala Glu Ser Trp Glu Ile Arg Ala Asp Ala Ile Arg Gln Lys 
            420                 425                 430         


Val Glu Arg His Phe Trp Met Glu Asp Leu Gly Tyr Tyr Ala Leu Ala 
        435                 440                 445             


Leu Asp Gly Asp Gly Leu Pro Cys Lys Val Arg Thr Ser Asn Ala Gly 
    450                 455                 460                 


His Leu Leu Tyr Val Gly Leu Pro Gly Pro Asp Arg Ala Arg Met Val 
465                 470                 475                 480 


Ala Asp Gln Leu Leu Ser Ala Ser Phe His Ser Gly Trp Gly Leu Arg 
                485                 490                 495     


Thr Leu Ala Asp Asp Ala Ile Phe Phe Asn Pro Met Ser Tyr His Asn 
            500                 505                 510         


Gly Ser Ile Trp Pro His Asp Thr Ala Ile Cys Ala Ala Gly Leu Ala 
        515                 520                 525             


Arg Tyr Gly Ser Arg Asp Ser Val Val Arg Leu Met Ser Gly Thr Phe 
    530                 535                 540                 


Glu Ser Ala Val His Phe Asn Met Arg Leu Pro Glu Leu Phe Cys Gly 
545                 550                 555                 560 


Phe Thr Arg Ala Ala Gly Glu Ala Pro Ile Ala Tyr Pro Val Ala Cys 
                565                 570                 575     


Leu Pro Gln Ala Trp Ser Ala Gly Ser Ala Phe Met Leu Met Gln Ser 
            580                 585                 590         


Cys Leu Gly Leu Gln Ile Asp Gly Trp Thr Gly Glu Ile His Val Thr 
        595                 600                 605             


Arg Pro Arg Leu Pro Ile Gly Ile Asp Asn Leu Val Ile Arg His Leu 
    610                 615                 620                 


Ser Val Gly Gln Ala Ala Val Asp Leu Thr Phe Gln Arg Val Gly Asp 
625                 630                 635                 640 


Arg Val Gly Ala Phe Leu Ala Glu Pro His Glu Gly Leu Val Pro Leu 
                645                 650                 655     


Val Val Arg Ser 
            660 


<210>  225
<211>  2376
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 218

<400>  225
atgaaatggg ctgcgaagcg gccaagatgc tcgtccatat gctgcagaag ggcgagatgc     60

catcaggcac gctgttgccg ccgcaactcg tcgtgcgcga gacggcctga gcacttcaac    120

tgggggagag gcatcatgca tggatgggtc atcaaagaaa acgacctgtt ttggtacgga    180

gacgcagagg gtctgagcgc gcacggagtt gaaaacgttt ccggtcacgg gctttacacc    240

agagacacgc gcgtgctctc agcgctcgtt tggcgcatcg agcccgacgt gtgggtggca    300

ttggacgccc ttgcggagtc cggctcggaa tcggtgtacc gttacaccaa tcgccctccg    360

cgggccgatc acgagcctcc gcgcgagagc ctgctggtgg agcgccggca gcgcgtggac    420

ggacattgct ttcaagaaag cggtatcgtg cgcaattttg gcgatcgcgc cgtgcgcctc    480

gcggtgatct acgaggtcgc ggcggacttc gcggacatgt tcgaagttcg ggggttccag    540

gtcgaggcgc ccgcgagagc gattcgttca cgggtgtccg gaaacgtttg cggtttttct    600

tattcgtcct ccgacgggcg gacttgggag acgcgcgtcc agctcgctgc gcatccgagt    660

cacgcgggtg agatgacgcc cgttcggtgg accgagtcgg ccggcgtggg ccgggcggag    720

ttgctgatca cggtggacgc cggaggtgcc gcggagtgga cgctcaccgt tcgaccggag    780

gtgcgcggag gcacggaatt ccccgccgca ggagaaacag ggatcggctt gtctgtttcc    840

gaaaacgttt ccagtcatcc gcgtggaaac gccgccgagg gcttgaggtc caggccagca    900

cggaacgctg aagatgacgc gtcctcagcg cggggatggt tgaatggcgc gccgacggtt    960

tccgggcatg aagcattcgg ccgctggtac gagcagggca tgcgggacat tcgcatgctc   1020

cagtccgact ttgggtttgg gccgtttctc gtggcggggg taccgtggta cgcagtcccg   1080

ttcggaaggg acagcttgat tgccgcccgg cagatccttt ccgcggcgcc ggaggtcgcg   1140

cgaggcactc tcgccacgct ggcccatttc cagggcgaac gtgtggacac ggagcgggat   1200

gagcagcctg ggaagattct gcacgaactc agggacggcg aactcgcgcg cagcggcaag   1260

gttccattcc gcccgtacta cggcagcatc gacgccacgc cgctctttct catcctcttg   1320

gcggactact ggcgcttcac aggcgacacg ccgttcctca cgcggatgct tccccatgcg   1380

gagcgggcgc ttgcgtggat ggcggattac ggcgatcgcg acggagacgg gttcatcgag   1440

tattggcgcg aggccgaggg cgggatcgcc aatcagggat ggaaggattc gggggactcg   1500

atggtccacg ccgacggcag cttggcgcaa ggccccatcg cgctcgcgga ggtccaggcg   1560

tacgcgtaca tggcgtacgt ggcttggcgt gagatttacc gcgagctcgg cgaacccgaa   1620

gaagcggagc ggctggcgag actcgcggat gggctgcgat ctcgcttcct gcagcacttc   1680

tggctggagg agaggaatga aatcgcaatg gcgcttgacg gaaacaagcg accgctttgc   1740

gtggcctcgt ccaacatggg ccaagtgctg tggagcgaca tcctgccgtc cgaagtggcc   1800

gagcgcgtcg caaagcgcct gctgcagccc gacctgttct cgggatttgg cattcgcacg   1860

ctctctgcga aggagctccg ctacaatccg atgagctatc acaacggttc ggtctggccg   1920

cacgatacca gcctcgtctt cgccgggctg gtgaggcacg gggcctggga ggaagccgag   1980

cagatcttcg aggggctcat gagggcgcag gcgcaatttc cgcaccatcg gctgccggag   2040

ttgttctgcg ggttttcccg tgaggaaagc cctcggcctg tcccgtaccc ggtttcatgc   2100

tcgccccagg cgtgggcggc ggcggttccg gccattgtgc tggagaacct gctgggtctc   2160

cgcccggacg cgcctcgggg agaattgacg attttcccgc gattgccggc gagcatgcag   2220

gagctgaagg tgcacgggct acggctcggc cgcgggaagc tgtcggtcga gatcgcgcgt   2280

cgggacggat gtgtcttggt cgacgtggtg gaaaacacca cgggcttgcg ggtggacgtg   2340

atggacggcg cgaaggaggt gatgtccgcc agctga                             2376


<210>  226
<211>  2376
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 218

<400>  226
atgagatggg ctgcgaggcg gccaagatgc tcgtccatat gctgcagaag ggcgagatgc     60

catcaggcac gctgttgccg ccgcaactcg tcgtgcgcga gacggcctga gcacttcaac    120

tgggggagag gcatcatgca tggatgggtc atcaaagaaa acgacctgtt ttggtacgga    180

gacgcagagg gtctgagcgc gcacggagtt gaaaacgttt ccggtcacgg gctttacacc    240

agagacacgc gcgtgctctc agcgctcgtt tggcgcatcg agcccgacgt gtgggtggca    300

ttggacgccc ttgcggagtc cggctcggaa tcggtgtacc gttacaccaa tcgccctccg    360

cgggccgatc acgagcctcc gcgcgagagc ctgctggtgg agcgccggca gcgcgtggac    420

ggacattgct ttcaagaaag cggtatcgtg cgcaattttg gcgatcgcgc cgtgcgcctc    480

gcggtgatct acgaggtcgc ggcggacttc gcggacatgt tcgaagttcg ggggttccag    540

gtcgaggcgc ccgcgagagc gattcgttca cgggtgtccg gaaacgtttg cggtttttct    600

tattcgtcct ccgacgggcg gacttgggag acgcgcgtcc agctcgctgc gcatccgagt    660

cacgcgggtg agatgacgcc cgttcggtgg accgagtcgg ccggcgtggg ccgggcggag    720

ttgctgatca cggtggacgc cggaggtgcc gcggagtgga cgctcaccgt tcgaccggag    780

gtgcgcggag gcacggaatt ccccgccgca ggagaaacag ggatcggctt gtctgtttcc    840

gaaaacgttt ccagtcatcc gcgtggaaac gccgccgagg gcttgaggtc caggccagca    900

cggaacgctg aagatgacgc gtcctcagcg cggggatggt tgaatggcgc gccgacggtt    960

tccgggcatg aagcattcgg ccgctggtac gagcagggca tgcgggacat tcgcatgctc   1020

cagtccgact ttgggtttgg gccgtttctc gtggcggggg taccgtggta cgcagtcccg   1080

ttcggaaggg acagcttgat tgccgcccgg cagatccttt ccgcggcgcc ggaggtcgcg   1140

cgaggcactc tcgccacgct ggcccatttc cagggcgaac gtgtggacac ggagcgggat   1200

gagcagcctg ggaagattct gcacgaactc agggacggcg aactcgcgcg cagcggcaag   1260

gttccattcc gcccgtacta cggcagcatc gacgccacgc cgctctttct catcctcttg   1320

gcggactact ggcgcttcac aggcgacacg ccgttcctca cgcggatgct tccccatgcg   1380

gagcgggcgc ttgcgtggat ggcggattac ggcgatcgcg acggagacgg gttcatcgag   1440

tattggcgcg aggccgaggg cgggatcgcc aatcagggat ggaaggattc gggggactcg   1500

atggtccacg ccgacggcag cttggcgcaa ggccccatcg cgctcgcgga ggtccaggcg   1560

tacgcgtaca tggcgtacgt ggcttggcgt gagatttacc gcgagctcgg cgaacccgaa   1620

gaagcggagc ggctggcgag actcgcggat gggctgcgat ctcgcttcct gcagcacttc   1680

tggctggagg agaggaatga aatcgcaatg gcgcttgacg gaaacaagcg accgctttgc   1740

gtggcctcgt ccaacatggg ccaagtgctg tggagcgaca tcctgccgtc cgaagtggcc   1800

gagcgcgtcg caaagcgcct gctgcagccc gacctgttct cgggatttgg cattcgcacg   1860

ctctctgcga aggagctccg ctacaatccg atgagctatc acaacggttc ggtctggccg   1920

cacgatacca gcctcgtctt cgccgggctg gtgaggcacg gggcctggga ggaagccgag   1980

cagatcttcg aggggctcat gagggcgcag gcgcaatttc cgcaccatcg gctgccggag   2040

ttgttctgcg ggttttcccg tgaggaaagc cctcggcctg tcccgtaccc ggtttcatgc   2100

tcgccccagg cgtgggcggc ggcggttccg gccattgtgc tggagaacct gctgggtctc   2160

cgcccggacg cgcctcgggg agaattgacg attttcccgc gattgccggc gagcatgcag   2220

gagctgaagg tgcacgggct acggctcggc cgcgggaagc tgtcggtcga gatcgcgcgt   2280

cgggacggat gtgtcttggt cgacgtggtg gaaaacacca cgggcttgcg ggtggacgtg   2340

atggacggcg cgaaggaggt gatgtccgcc agctga                             2376


<210>  227
<211>  2376
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 218

<400>  227
atgagatggg ctgcgaagaa gccaagatgc tcgtccatat gctgcagaag ggcgagatgc     60

catcaggcac gctgttgccg ccgcaactcg tcgtgcgcga gacggcctga gcacttcaac    120

tgggggagag gcatcatgca tggatgggtc atcaaagaaa acgacctgtt ttggtacgga    180

gacgcagagg gtctgagcgc gcacggagtt gaaaacgttt ccggtcacgg gctttacacc    240

agagacacgc gcgtgctctc agcgctcgtt tggcgcatcg agcccgacgt gtgggtggca    300

ttggacgccc ttgcggagtc cggctcggaa tcggtgtacc gttacaccaa tcgccctccg    360

cgggccgatc acgagcctcc gcgcgagagc ctgctggtgg agcgccggca gcgcgtggac    420

ggacattgct ttcaagaaag cggtatcgtg cgcaattttg gcgatcgcgc cgtgcgcctc    480

gcggtgatct acgaggtcgc ggcggacttc gcggacatgt tcgaagttcg ggggttccag    540

gtcgaggcgc ccgcgagagc gattcgttca cgggtgtccg gaaacgtttg cggtttttct    600

tattcgtcct ccgacgggcg gacttgggag acgcgcgtcc agctcgctgc gcatccgagt    660

cacgcgggtg agatgacgcc cgttcggtgg accgagtcgg ccggcgtggg ccgggcggag    720

ttgctgatca cggtggacgc cggaggtgcc gcggagtgga cgctcaccgt tcgaccggag    780

gtgcgcggag gcacggaatt ccccgccgca ggagaaacag ggatcggctt gtctgtttcc    840

gaaaacgttt ccagtcatcc gcgtggaaac gccgccgagg gcttgaggtc caggccagca    900

cggaacgctg aagatgacgc gtcctcagcg cggggatggt tgaatggcgc gccgacggtt    960

tccgggcatg aagcattcgg ccgctggtac gagcagggca tgcgggacat tcgcatgctc   1020

cagtccgact ttgggtttgg gccgtttctc gtggcggggg taccgtggta cgcagtcccg   1080

ttcggaaggg acagcttgat tgccgcccgg cagatccttt ccgcggcgcc ggaggtcgcg   1140

cgaggcactc tcgccacgct ggcccatttc cagggcgaac gtgtggacac ggagcgggat   1200

gagcagcctg ggaagattct gcacgaactc agggacggcg aactcgcgcg cagcggcaag   1260

gttccattcc gcccgtacta cggcagcatc gacgccacgc cgctctttct catcctcttg   1320

gcggactact ggcgcttcac aggcgacacg ccgttcctca cgcggatgct tccccatgcg   1380

gagcgggcgc ttgcgtggat ggcggattac ggcgatcgcg acggagacgg gttcatcgag   1440

tattggcgcg aggccgaggg cgggatcgcc aatcagggat ggaaggattc gggggactcg   1500

atggtccacg ccgacggcag cttggcgcaa ggccccatcg cgctcgcgga ggtccaggcg   1560

tacgcgtaca tggcgtacgt ggcttggcgt gagatttacc gcgagctcgg cgaacccgaa   1620

gaagcggagc ggctggcgag actcgcggat gggctgcgat ctcgcttcct gcagcacttc   1680

tggctggagg agaggaatga aatcgcaatg gcgcttgacg gaaacaagcg accgctttgc   1740

gtggcctcgt ccaacatggg ccaagtgctg tggagcgaca tcctgccgtc cgaagtggcc   1800

gagcgcgtcg caaagcgcct gctgcagccc gacctgttct cgggatttgg cattcgcacg   1860

ctctctgcga aggagctccg ctacaatccg atgagctatc acaacggttc ggtctggccg   1920

cacgatacca gcctcgtctt cgccgggctg gtgaggcacg gggcctggga ggaagccgag   1980

cagatcttcg aggggctcat gagggcgcag gcgcaatttc cgcaccatcg gctgccggag   2040

ttgttctgcg ggttttcccg tgaggaaagc cctcggcctg tcccgtaccc ggtttcatgc   2100

tcgccccagg cgtgggcggc ggcggttccg gccattgtgc tggagaacct gctgggtctc   2160

cgcccggacg cgcctcgggg agaattgacg attttcccgc gattgccggc gagcatgcag   2220

gagctgaagg tgcacgggct acggctcggc cgcgggaagc tgtcggtcga gatcgcgcgt   2280

cgggacggat gtgtcttggt cgacgtggtg gaaaacacca cgggcttgcg ggtggacgtg   2340

atggacggcg cgaaggaggt gatgtccgcc agctga                             2376


<210>  228
<211>  2376
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 218

<400>  228
atgagatggg ctgcgaagcg gccaaaatgc tcgtccatat gctgcagaag ggcgagatgc     60

catcaggcac gctgttgccg ccgcaactcg tcgtgcgcga gacggcctga gcacttcaac    120

tgggggagag gcatcatgca tggatgggtc atcaaagaaa acgacctgtt ttggtacgga    180

gacgcagagg gtctgagcgc gcacggagtt gaaaacgttt ccggtcacgg gctttacacc    240

agagacacgc gcgtgctctc agcgctcgtt tggcgcatcg agcccgacgt gtgggtggca    300

ttggacgccc ttgcggagtc cggctcggaa tcggtgtacc gttacaccaa tcgccctccg    360

cgggccgatc acgagcctcc gcgcgagagc ctgctggtgg agcgccggca gcgcgtggac    420

ggacattgct ttcaagaaag cggtatcgtg cgcaattttg gcgatcgcgc cgtgcgcctc    480

gcggtgatct acgaggtcgc ggcggacttc gcggacatgt tcgaagttcg ggggttccag    540

gtcgaggcgc ccgcgagagc gattcgttca cgggtgtccg gaaacgtttg cggtttttct    600

tattcgtcct ccgacgggcg gacttgggag acgcgcgtcc agctcgctgc gcatccgagt    660

cacgcgggtg agatgacgcc cgttcggtgg accgagtcgg ccggcgtggg ccgggcggag    720

ttgctgatca cggtggacgc cggaggtgcc gcggagtgga cgctcaccgt tcgaccggag    780

gtgcgcggag gcacggaatt ccccgccgca ggagaaacag ggatcggctt gtctgtttcc    840

gaaaacgttt ccagtcatcc gcgtggaaac gccgccgagg gcttgaggtc caggccagca    900

cggaacgctg aagatgacgc gtcctcagcg cggggatggt tgaatggcgc gccgacggtt    960

tccgggcatg aagcattcgg ccgctggtac gagcagggca tgcgggacat tcgcatgctc   1020

cagtccgact ttgggtttgg gccgtttctc gtggcggggg taccgtggta cgcagtcccg   1080

ttcggaaggg acagcttgat tgccgcccgg cagatccttt ccgcggcgcc ggaggtcgcg   1140

cgaggcactc tcgccacgct ggcccatttc cagggcgaac gtgtggacac ggagcgggat   1200

gagcagcctg ggaagattct gcacgaactc agggacggcg aactcgcgcg cagcggcaag   1260

gttccattcc gcccgtacta cggcagcatc gacgccacgc cgctctttct catcctcttg   1320

gcggactact ggcgcttcac aggcgacacg ccgttcctca cgcggatgct tccccatgcg   1380

gagcgggcgc ttgcgtggat ggcggattac ggcgatcgcg acggagacgg gttcatcgag   1440

tattggcgcg aggccgaggg cgggatcgcc aatcagggat ggaaggattc gggggactcg   1500

atggtccacg ccgacggcag cttggcgcaa ggccccatcg cgctcgcgga ggtccaggcg   1560

tacgcgtaca tggcgtacgt ggcttggcgt gagatttacc gcgagctcgg cgaacccgaa   1620

gaagcggagc ggctggcgag actcgcggat gggctgcgat ctcgcttcct gcagcacttc   1680

tggctggagg agaggaatga aatcgcaatg gcgcttgacg gaaacaagcg accgctttgc   1740

gtggcctcgt ccaacatggg ccaagtgctg tggagcgaca tcctgccgtc cgaagtggcc   1800

gagcgcgtcg caaagcgcct gctgcagccc gacctgttct cgggatttgg cattcgcacg   1860

ctctctgcga aggagctccg ctacaatccg atgagctatc acaacggttc ggtctggccg   1920

cacgatacca gcctcgtctt cgccgggctg gtgaggcacg gggcctggga ggaagccgag   1980

cagatcttcg aggggctcat gagggcgcag gcgcaatttc cgcaccatcg gctgccggag   2040

ttgttctgcg ggttttcccg tgaggaaagc cctcggcctg tcccgtaccc ggtttcatgc   2100

tcgccccagg cgtgggcggc ggcggttccg gccattgtgc tggagaacct gctgggtctc   2160

cgcccggacg cgcctcgggg agaattgacg attttcccgc gattgccggc gagcatgcag   2220

gagctgaagg tgcacgggct acggctcggc cgcgggaagc tgtcggtcga gatcgcgcgt   2280

cgggacggat gtgtcttggt cgacgtggtg gaaaacacca cgggcttgcg ggtggacgtg   2340

atggacggcg cgaaggaggt gatgtccgcc agctga                             2376


<210>  229
<211>  2376
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 218

<400>  229
atgagatggg ctgcgaagcg gccaagatgc tcgtccatat gctgcaaaag ggcgagatgc     60

catcaggcac gctgttgccg ccgcaactcg tcgtgcgcga gacggcctga gcacttcaac    120

tgggggagag gcatcatgca tggatgggtc atcaaagaaa acgacctgtt ttggtacgga    180

gacgcagagg gtctgagcgc gcacggagtt gaaaacgttt ccggtcacgg gctttacacc    240

agagacacgc gcgtgctctc agcgctcgtt tggcgcatcg agcccgacgt gtgggtggca    300

ttggacgccc ttgcggagtc cggctcggaa tcggtgtacc gttacaccaa tcgccctccg    360

cgggccgatc acgagcctcc gcgcgagagc ctgctggtgg agcgccggca gcgcgtggac    420

ggacattgct ttcaagaaag cggtatcgtg cgcaattttg gcgatcgcgc cgtgcgcctc    480

gcggtgatct acgaggtcgc ggcggacttc gcggacatgt tcgaagttcg ggggttccag    540

gtcgaggcgc ccgcgagagc gattcgttca cgggtgtccg gaaacgtttg cggtttttct    600

tattcgtcct ccgacgggcg gacttgggag acgcgcgtcc agctcgctgc gcatccgagt    660

cacgcgggtg agatgacgcc cgttcggtgg accgagtcgg ccggcgtggg ccgggcggag    720

ttgctgatca cggtggacgc cggaggtgcc gcggagtgga cgctcaccgt tcgaccggag    780

gtgcgcggag gcacggaatt ccccgccgca ggagaaacag ggatcggctt gtctgtttcc    840

gaaaacgttt ccagtcatcc gcgtggaaac gccgccgagg gcttgaggtc caggccagca    900

cggaacgctg aagatgacgc gtcctcagcg cggggatggt tgaatggcgc gccgacggtt    960

tccgggcatg aagcattcgg ccgctggtac gagcagggca tgcgggacat tcgcatgctc   1020

cagtccgact ttgggtttgg gccgtttctc gtggcggggg taccgtggta cgcagtcccg   1080

ttcggaaggg acagcttgat tgccgcccgg cagatccttt ccgcggcgcc ggaggtcgcg   1140

cgaggcactc tcgccacgct ggcccatttc cagggcgaac gtgtggacac ggagcgggat   1200

gagcagcctg ggaagattct gcacgaactc agggacggcg aactcgcgcg cagcggcaag   1260

gttccattcc gcccgtacta cggcagcatc gacgccacgc cgctctttct catcctcttg   1320

gcggactact ggcgcttcac aggcgacacg ccgttcctca cgcggatgct tccccatgcg   1380

gagcgggcgc ttgcgtggat ggcggattac ggcgatcgcg acggagacgg gttcatcgag   1440

tattggcgcg aggccgaggg cgggatcgcc aatcagggat ggaaggattc gggggactcg   1500

atggtccacg ccgacggcag cttggcgcaa ggccccatcg cgctcgcgga ggtccaggcg   1560

tacgcgtaca tggcgtacgt ggcttggcgt gagatttacc gcgagctcgg cgaacccgaa   1620

gaagcggagc ggctggcgag actcgcggat gggctgcgat ctcgcttcct gcagcacttc   1680

tggctggagg agaggaatga aatcgcaatg gcgcttgacg gaaacaagcg accgctttgc   1740

gtggcctcgt ccaacatggg ccaagtgctg tggagcgaca tcctgccgtc cgaagtggcc   1800

gagcgcgtcg caaagcgcct gctgcagccc gacctgttct cgggatttgg cattcgcacg   1860

ctctctgcga aggagctccg ctacaatccg atgagctatc acaacggttc ggtctggccg   1920

cacgatacca gcctcgtctt cgccgggctg gtgaggcacg gggcctggga ggaagccgag   1980

cagatcttcg aggggctcat gagggcgcag gcgcaatttc cgcaccatcg gctgccggag   2040

ttgttctgcg ggttttcccg tgaggaaagc cctcggcctg tcccgtaccc ggtttcatgc   2100

tcgccccagg cgtgggcggc ggcggttccg gccattgtgc tggagaacct gctgggtctc   2160

cgcccggacg cgcctcgggg agaattgacg attttcccgc gattgccggc gagcatgcag   2220

gagctgaagg tgcacgggct acggctcggc cgcgggaagc tgtcggtcga gatcgcgcgt   2280

cgggacggat gtgtcttggt cgacgtggtg gaaaacacca cgggcttgcg ggtggacgtg   2340

atggacggcg cgaaggaggt gatgtccgcc agctga                             2376


<210>  230
<211>  791
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:219 and encoded by SEQ ID NO:225

<400>  230

Met Lys Trp Ala Ala Lys Arg Pro Arg Cys Ser Ser Ile Cys Cys Arg 
1               5                   10                  15      


Arg Ala Arg Cys His Gln Ala Arg Cys Cys Arg Arg Asn Ser Ser Cys 
            20                  25                  30          


Ala Arg Arg Pro Glu His Phe Asn Trp Gly Arg Gly Ile Met His Gly 
        35                  40                  45              


Trp Val Ile Lys Glu Asn Asp Leu Phe Trp Tyr Gly Asp Ala Glu Gly 
    50                  55                  60                  


Leu Ser Ala His Gly Val Glu Asn Val Ser Gly His Gly Leu Tyr Thr 
65                  70                  75                  80  


Arg Asp Thr Arg Val Leu Ser Ala Leu Val Trp Arg Ile Glu Pro Asp 
                85                  90                  95      


Val Trp Val Ala Leu Asp Ala Leu Ala Glu Ser Gly Ser Glu Ser Val 
            100                 105                 110         


Tyr Arg Tyr Thr Asn Arg Pro Pro Arg Ala Asp His Glu Pro Pro Arg 
        115                 120                 125             


Glu Ser Leu Leu Val Glu Arg Arg Gln Arg Val Asp Gly His Cys Phe 
    130                 135                 140                 


Gln Glu Ser Gly Ile Val Arg Asn Phe Gly Asp Arg Ala Val Arg Leu 
145                 150                 155                 160 


Ala Val Ile Tyr Glu Val Ala Ala Asp Phe Ala Asp Met Phe Glu Val 
                165                 170                 175     


Arg Gly Phe Gln Val Glu Ala Pro Ala Arg Ala Ile Arg Ser Arg Val 
            180                 185                 190         


Ser Gly Asn Val Cys Gly Phe Ser Tyr Ser Ser Ser Asp Gly Arg Thr 
        195                 200                 205             


Trp Glu Thr Arg Val Gln Leu Ala Ala His Pro Ser His Ala Gly Glu 
    210                 215                 220                 


Met Thr Pro Val Arg Trp Thr Glu Ser Ala Gly Val Gly Arg Ala Glu 
225                 230                 235                 240 


Leu Leu Ile Thr Val Asp Ala Gly Gly Ala Ala Glu Trp Thr Leu Thr 
                245                 250                 255     


Val Arg Pro Glu Val Arg Gly Gly Thr Glu Phe Pro Ala Ala Gly Glu 
            260                 265                 270         


Thr Gly Ile Gly Leu Ser Val Ser Glu Asn Val Ser Ser His Pro Arg 
        275                 280                 285             


Gly Asn Ala Ala Glu Gly Leu Arg Ser Arg Pro Ala Arg Asn Ala Glu 
    290                 295                 300                 


Asp Asp Ala Ser Ser Ala Arg Gly Trp Leu Asn Gly Ala Pro Thr Val 
305                 310                 315                 320 


Ser Gly His Glu Ala Phe Gly Arg Trp Tyr Glu Gln Gly Met Arg Asp 
                325                 330                 335     


Ile Arg Met Leu Gln Ser Asp Phe Gly Phe Gly Pro Phe Leu Val Ala 
            340                 345                 350         


Gly Val Pro Trp Tyr Ala Val Pro Phe Gly Arg Asp Ser Leu Ile Ala 
        355                 360                 365             


Ala Arg Gln Ile Leu Ser Ala Ala Pro Glu Val Ala Arg Gly Thr Leu 
    370                 375                 380                 


Ala Thr Leu Ala His Phe Gln Gly Glu Arg Val Asp Thr Glu Arg Asp 
385                 390                 395                 400 


Glu Gln Pro Gly Lys Ile Leu His Glu Leu Arg Asp Gly Glu Leu Ala 
                405                 410                 415     


Arg Ser Gly Lys Val Pro Phe Arg Pro Tyr Tyr Gly Ser Ile Asp Ala 
            420                 425                 430         


Thr Pro Leu Phe Leu Ile Leu Leu Ala Asp Tyr Trp Arg Phe Thr Gly 
        435                 440                 445             


Asp Thr Pro Phe Leu Thr Arg Met Leu Pro His Ala Glu Arg Ala Leu 
    450                 455                 460                 


Ala Trp Met Ala Asp Tyr Gly Asp Arg Asp Gly Asp Gly Phe Ile Glu 
465                 470                 475                 480 


Tyr Trp Arg Glu Ala Glu Gly Gly Ile Ala Asn Gln Gly Trp Lys Asp 
                485                 490                 495     


Ser Gly Asp Ser Met Val His Ala Asp Gly Ser Leu Ala Gln Gly Pro 
            500                 505                 510         


Ile Ala Leu Ala Glu Val Gln Ala Tyr Ala Tyr Met Ala Tyr Val Ala 
        515                 520                 525             


Trp Arg Glu Ile Tyr Arg Glu Leu Gly Glu Pro Glu Glu Ala Glu Arg 
    530                 535                 540                 


Leu Ala Arg Leu Ala Asp Gly Leu Arg Ser Arg Phe Leu Gln His Phe 
545                 550                 555                 560 


Trp Leu Glu Glu Arg Asn Glu Ile Ala Met Ala Leu Asp Gly Asn Lys 
                565                 570                 575     


Arg Pro Leu Cys Val Ala Ser Ser Asn Met Gly Gln Val Leu Trp Ser 
            580                 585                 590         


Asp Ile Leu Pro Ser Glu Val Ala Glu Arg Val Ala Lys Arg Leu Leu 
        595                 600                 605             


Gln Pro Asp Leu Phe Ser Gly Phe Gly Ile Arg Thr Leu Ser Ala Lys 
    610                 615                 620                 


Glu Leu Arg Tyr Asn Pro Met Ser Tyr His Asn Gly Ser Val Trp Pro 
625                 630                 635                 640 


His Asp Thr Ser Leu Val Phe Ala Gly Leu Val Arg His Gly Ala Trp 
                645                 650                 655     


Glu Glu Ala Glu Gln Ile Phe Glu Gly Leu Met Arg Ala Gln Ala Gln 
            660                 665                 670         


Phe Pro His His Arg Leu Pro Glu Leu Phe Cys Gly Phe Ser Arg Glu 
        675                 680                 685             


Glu Ser Pro Arg Pro Val Pro Tyr Pro Val Ser Cys Ser Pro Gln Ala 
    690                 695                 700                 


Trp Ala Ala Ala Val Pro Ala Ile Val Leu Glu Asn Leu Leu Gly Leu 
705                 710                 715                 720 


Arg Pro Asp Ala Pro Arg Gly Glu Leu Thr Ile Phe Pro Arg Leu Pro 
                725                 730                 735     


Ala Ser Met Gln Glu Leu Lys Val His Gly Leu Arg Leu Gly Arg Gly 
            740                 745                 750         


Lys Leu Ser Val Glu Ile Ala Arg Arg Asp Gly Cys Val Leu Val Asp 
        755                 760                 765             


Val Val Glu Asn Thr Thr Gly Leu Arg Val Asp Val Met Asp Gly Ala 
    770                 775                 780                 


Lys Glu Val Met Ser Ala Ser 
785                 790     


<210>  231
<211>  791
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:219 and encoded by SEQ ID NO:226

<400>  231

Met Arg Trp Ala Ala Arg Arg Pro Arg Cys Ser Ser Ile Cys Cys Arg 
1               5                   10                  15      


Arg Ala Arg Cys His Gln Ala Arg Cys Cys Arg Arg Asn Ser Ser Cys 
            20                  25                  30          


Ala Arg Arg Pro Glu His Phe Asn Trp Gly Arg Gly Ile Met His Gly 
        35                  40                  45              


Trp Val Ile Lys Glu Asn Asp Leu Phe Trp Tyr Gly Asp Ala Glu Gly 
    50                  55                  60                  


Leu Ser Ala His Gly Val Glu Asn Val Ser Gly His Gly Leu Tyr Thr 
65                  70                  75                  80  


Arg Asp Thr Arg Val Leu Ser Ala Leu Val Trp Arg Ile Glu Pro Asp 
                85                  90                  95      


Val Trp Val Ala Leu Asp Ala Leu Ala Glu Ser Gly Ser Glu Ser Val 
            100                 105                 110         


Tyr Arg Tyr Thr Asn Arg Pro Pro Arg Ala Asp His Glu Pro Pro Arg 
        115                 120                 125             


Glu Ser Leu Leu Val Glu Arg Arg Gln Arg Val Asp Gly His Cys Phe 
    130                 135                 140                 


Gln Glu Ser Gly Ile Val Arg Asn Phe Gly Asp Arg Ala Val Arg Leu 
145                 150                 155                 160 


Ala Val Ile Tyr Glu Val Ala Ala Asp Phe Ala Asp Met Phe Glu Val 
                165                 170                 175     


Arg Gly Phe Gln Val Glu Ala Pro Ala Arg Ala Ile Arg Ser Arg Val 
            180                 185                 190         


Ser Gly Asn Val Cys Gly Phe Ser Tyr Ser Ser Ser Asp Gly Arg Thr 
        195                 200                 205             


Trp Glu Thr Arg Val Gln Leu Ala Ala His Pro Ser His Ala Gly Glu 
    210                 215                 220                 


Met Thr Pro Val Arg Trp Thr Glu Ser Ala Gly Val Gly Arg Ala Glu 
225                 230                 235                 240 


Leu Leu Ile Thr Val Asp Ala Gly Gly Ala Ala Glu Trp Thr Leu Thr 
                245                 250                 255     


Val Arg Pro Glu Val Arg Gly Gly Thr Glu Phe Pro Ala Ala Gly Glu 
            260                 265                 270         


Thr Gly Ile Gly Leu Ser Val Ser Glu Asn Val Ser Ser His Pro Arg 
        275                 280                 285             


Gly Asn Ala Ala Glu Gly Leu Arg Ser Arg Pro Ala Arg Asn Ala Glu 
    290                 295                 300                 


Asp Asp Ala Ser Ser Ala Arg Gly Trp Leu Asn Gly Ala Pro Thr Val 
305                 310                 315                 320 


Ser Gly His Glu Ala Phe Gly Arg Trp Tyr Glu Gln Gly Met Arg Asp 
                325                 330                 335     


Ile Arg Met Leu Gln Ser Asp Phe Gly Phe Gly Pro Phe Leu Val Ala 
            340                 345                 350         


Gly Val Pro Trp Tyr Ala Val Pro Phe Gly Arg Asp Ser Leu Ile Ala 
        355                 360                 365             


Ala Arg Gln Ile Leu Ser Ala Ala Pro Glu Val Ala Arg Gly Thr Leu 
    370                 375                 380                 


Ala Thr Leu Ala His Phe Gln Gly Glu Arg Val Asp Thr Glu Arg Asp 
385                 390                 395                 400 


Glu Gln Pro Gly Lys Ile Leu His Glu Leu Arg Asp Gly Glu Leu Ala 
                405                 410                 415     


Arg Ser Gly Lys Val Pro Phe Arg Pro Tyr Tyr Gly Ser Ile Asp Ala 
            420                 425                 430         


Thr Pro Leu Phe Leu Ile Leu Leu Ala Asp Tyr Trp Arg Phe Thr Gly 
        435                 440                 445             


Asp Thr Pro Phe Leu Thr Arg Met Leu Pro His Ala Glu Arg Ala Leu 
    450                 455                 460                 


Ala Trp Met Ala Asp Tyr Gly Asp Arg Asp Gly Asp Gly Phe Ile Glu 
465                 470                 475                 480 


Tyr Trp Arg Glu Ala Glu Gly Gly Ile Ala Asn Gln Gly Trp Lys Asp 
                485                 490                 495     


Ser Gly Asp Ser Met Val His Ala Asp Gly Ser Leu Ala Gln Gly Pro 
            500                 505                 510         


Ile Ala Leu Ala Glu Val Gln Ala Tyr Ala Tyr Met Ala Tyr Val Ala 
        515                 520                 525             


Trp Arg Glu Ile Tyr Arg Glu Leu Gly Glu Pro Glu Glu Ala Glu Arg 
    530                 535                 540                 


Leu Ala Arg Leu Ala Asp Gly Leu Arg Ser Arg Phe Leu Gln His Phe 
545                 550                 555                 560 


Trp Leu Glu Glu Arg Asn Glu Ile Ala Met Ala Leu Asp Gly Asn Lys 
                565                 570                 575     


Arg Pro Leu Cys Val Ala Ser Ser Asn Met Gly Gln Val Leu Trp Ser 
            580                 585                 590         


Asp Ile Leu Pro Ser Glu Val Ala Glu Arg Val Ala Lys Arg Leu Leu 
        595                 600                 605             


Gln Pro Asp Leu Phe Ser Gly Phe Gly Ile Arg Thr Leu Ser Ala Lys 
    610                 615                 620                 


Glu Leu Arg Tyr Asn Pro Met Ser Tyr His Asn Gly Ser Val Trp Pro 
625                 630                 635                 640 


His Asp Thr Ser Leu Val Phe Ala Gly Leu Val Arg His Gly Ala Trp 
                645                 650                 655     


Glu Glu Ala Glu Gln Ile Phe Glu Gly Leu Met Arg Ala Gln Ala Gln 
            660                 665                 670         


Phe Pro His His Arg Leu Pro Glu Leu Phe Cys Gly Phe Ser Arg Glu 
        675                 680                 685             


Glu Ser Pro Arg Pro Val Pro Tyr Pro Val Ser Cys Ser Pro Gln Ala 
    690                 695                 700                 


Trp Ala Ala Ala Val Pro Ala Ile Val Leu Glu Asn Leu Leu Gly Leu 
705                 710                 715                 720 


Arg Pro Asp Ala Pro Arg Gly Glu Leu Thr Ile Phe Pro Arg Leu Pro 
                725                 730                 735     


Ala Ser Met Gln Glu Leu Lys Val His Gly Leu Arg Leu Gly Arg Gly 
            740                 745                 750         


Lys Leu Ser Val Glu Ile Ala Arg Arg Asp Gly Cys Val Leu Val Asp 
        755                 760                 765             


Val Val Glu Asn Thr Thr Gly Leu Arg Val Asp Val Met Asp Gly Ala 
    770                 775                 780                 


Lys Glu Val Met Ser Ala Ser 
785                 790     


<210>  232
<211>  791
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:219 and encoded by SEQ ID NO:227

<400>  232

Met Arg Trp Ala Ala Lys Lys Pro Arg Cys Ser Ser Ile Cys Cys Arg 
1               5                   10                  15      


Arg Ala Arg Cys His Gln Ala Arg Cys Cys Arg Arg Asn Ser Ser Cys 
            20                  25                  30          


Ala Arg Arg Pro Glu His Phe Asn Trp Gly Arg Gly Ile Met His Gly 
        35                  40                  45              


Trp Val Ile Lys Glu Asn Asp Leu Phe Trp Tyr Gly Asp Ala Glu Gly 
    50                  55                  60                  


Leu Ser Ala His Gly Val Glu Asn Val Ser Gly His Gly Leu Tyr Thr 
65                  70                  75                  80  


Arg Asp Thr Arg Val Leu Ser Ala Leu Val Trp Arg Ile Glu Pro Asp 
                85                  90                  95      


Val Trp Val Ala Leu Asp Ala Leu Ala Glu Ser Gly Ser Glu Ser Val 
            100                 105                 110         


Tyr Arg Tyr Thr Asn Arg Pro Pro Arg Ala Asp His Glu Pro Pro Arg 
        115                 120                 125             


Glu Ser Leu Leu Val Glu Arg Arg Gln Arg Val Asp Gly His Cys Phe 
    130                 135                 140                 


Gln Glu Ser Gly Ile Val Arg Asn Phe Gly Asp Arg Ala Val Arg Leu 
145                 150                 155                 160 


Ala Val Ile Tyr Glu Val Ala Ala Asp Phe Ala Asp Met Phe Glu Val 
                165                 170                 175     


Arg Gly Phe Gln Val Glu Ala Pro Ala Arg Ala Ile Arg Ser Arg Val 
            180                 185                 190         


Ser Gly Asn Val Cys Gly Phe Ser Tyr Ser Ser Ser Asp Gly Arg Thr 
        195                 200                 205             


Trp Glu Thr Arg Val Gln Leu Ala Ala His Pro Ser His Ala Gly Glu 
    210                 215                 220                 


Met Thr Pro Val Arg Trp Thr Glu Ser Ala Gly Val Gly Arg Ala Glu 
225                 230                 235                 240 


Leu Leu Ile Thr Val Asp Ala Gly Gly Ala Ala Glu Trp Thr Leu Thr 
                245                 250                 255     


Val Arg Pro Glu Val Arg Gly Gly Thr Glu Phe Pro Ala Ala Gly Glu 
            260                 265                 270         


Thr Gly Ile Gly Leu Ser Val Ser Glu Asn Val Ser Ser His Pro Arg 
        275                 280                 285             


Gly Asn Ala Ala Glu Gly Leu Arg Ser Arg Pro Ala Arg Asn Ala Glu 
    290                 295                 300                 


Asp Asp Ala Ser Ser Ala Arg Gly Trp Leu Asn Gly Ala Pro Thr Val 
305                 310                 315                 320 


Ser Gly His Glu Ala Phe Gly Arg Trp Tyr Glu Gln Gly Met Arg Asp 
                325                 330                 335     


Ile Arg Met Leu Gln Ser Asp Phe Gly Phe Gly Pro Phe Leu Val Ala 
            340                 345                 350         


Gly Val Pro Trp Tyr Ala Val Pro Phe Gly Arg Asp Ser Leu Ile Ala 
        355                 360                 365             


Ala Arg Gln Ile Leu Ser Ala Ala Pro Glu Val Ala Arg Gly Thr Leu 
    370                 375                 380                 


Ala Thr Leu Ala His Phe Gln Gly Glu Arg Val Asp Thr Glu Arg Asp 
385                 390                 395                 400 


Glu Gln Pro Gly Lys Ile Leu His Glu Leu Arg Asp Gly Glu Leu Ala 
                405                 410                 415     


Arg Ser Gly Lys Val Pro Phe Arg Pro Tyr Tyr Gly Ser Ile Asp Ala 
            420                 425                 430         


Thr Pro Leu Phe Leu Ile Leu Leu Ala Asp Tyr Trp Arg Phe Thr Gly 
        435                 440                 445             


Asp Thr Pro Phe Leu Thr Arg Met Leu Pro His Ala Glu Arg Ala Leu 
    450                 455                 460                 


Ala Trp Met Ala Asp Tyr Gly Asp Arg Asp Gly Asp Gly Phe Ile Glu 
465                 470                 475                 480 


Tyr Trp Arg Glu Ala Glu Gly Gly Ile Ala Asn Gln Gly Trp Lys Asp 
                485                 490                 495     


Ser Gly Asp Ser Met Val His Ala Asp Gly Ser Leu Ala Gln Gly Pro 
            500                 505                 510         


Ile Ala Leu Ala Glu Val Gln Ala Tyr Ala Tyr Met Ala Tyr Val Ala 
        515                 520                 525             


Trp Arg Glu Ile Tyr Arg Glu Leu Gly Glu Pro Glu Glu Ala Glu Arg 
    530                 535                 540                 


Leu Ala Arg Leu Ala Asp Gly Leu Arg Ser Arg Phe Leu Gln His Phe 
545                 550                 555                 560 


Trp Leu Glu Glu Arg Asn Glu Ile Ala Met Ala Leu Asp Gly Asn Lys 
                565                 570                 575     


Arg Pro Leu Cys Val Ala Ser Ser Asn Met Gly Gln Val Leu Trp Ser 
            580                 585                 590         


Asp Ile Leu Pro Ser Glu Val Ala Glu Arg Val Ala Lys Arg Leu Leu 
        595                 600                 605             


Gln Pro Asp Leu Phe Ser Gly Phe Gly Ile Arg Thr Leu Ser Ala Lys 
    610                 615                 620                 


Glu Leu Arg Tyr Asn Pro Met Ser Tyr His Asn Gly Ser Val Trp Pro 
625                 630                 635                 640 


His Asp Thr Ser Leu Val Phe Ala Gly Leu Val Arg His Gly Ala Trp 
                645                 650                 655     


Glu Glu Ala Glu Gln Ile Phe Glu Gly Leu Met Arg Ala Gln Ala Gln 
            660                 665                 670         


Phe Pro His His Arg Leu Pro Glu Leu Phe Cys Gly Phe Ser Arg Glu 
        675                 680                 685             


Glu Ser Pro Arg Pro Val Pro Tyr Pro Val Ser Cys Ser Pro Gln Ala 
    690                 695                 700                 


Trp Ala Ala Ala Val Pro Ala Ile Val Leu Glu Asn Leu Leu Gly Leu 
705                 710                 715                 720 


Arg Pro Asp Ala Pro Arg Gly Glu Leu Thr Ile Phe Pro Arg Leu Pro 
                725                 730                 735     


Ala Ser Met Gln Glu Leu Lys Val His Gly Leu Arg Leu Gly Arg Gly 
            740                 745                 750         


Lys Leu Ser Val Glu Ile Ala Arg Arg Asp Gly Cys Val Leu Val Asp 
        755                 760                 765             


Val Val Glu Asn Thr Thr Gly Leu Arg Val Asp Val Met Asp Gly Ala 
    770                 775                 780                 


Lys Glu Val Met Ser Ala Ser 
785                 790     


<210>  233
<211>  791
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:219 and encoded by SEQ ID NO:228

<400>  233

Met Arg Trp Ala Ala Lys Arg Pro Lys Cys Ser Ser Ile Cys Cys Arg 
1               5                   10                  15      


Arg Ala Arg Cys His Gln Ala Arg Cys Cys Arg Arg Asn Ser Ser Cys 
            20                  25                  30          


Ala Arg Arg Pro Glu His Phe Asn Trp Gly Arg Gly Ile Met His Gly 
        35                  40                  45              


Trp Val Ile Lys Glu Asn Asp Leu Phe Trp Tyr Gly Asp Ala Glu Gly 
    50                  55                  60                  


Leu Ser Ala His Gly Val Glu Asn Val Ser Gly His Gly Leu Tyr Thr 
65                  70                  75                  80  


Arg Asp Thr Arg Val Leu Ser Ala Leu Val Trp Arg Ile Glu Pro Asp 
                85                  90                  95      


Val Trp Val Ala Leu Asp Ala Leu Ala Glu Ser Gly Ser Glu Ser Val 
            100                 105                 110         


Tyr Arg Tyr Thr Asn Arg Pro Pro Arg Ala Asp His Glu Pro Pro Arg 
        115                 120                 125             


Glu Ser Leu Leu Val Glu Arg Arg Gln Arg Val Asp Gly His Cys Phe 
    130                 135                 140                 


Gln Glu Ser Gly Ile Val Arg Asn Phe Gly Asp Arg Ala Val Arg Leu 
145                 150                 155                 160 


Ala Val Ile Tyr Glu Val Ala Ala Asp Phe Ala Asp Met Phe Glu Val 
                165                 170                 175     


Arg Gly Phe Gln Val Glu Ala Pro Ala Arg Ala Ile Arg Ser Arg Val 
            180                 185                 190         


Ser Gly Asn Val Cys Gly Phe Ser Tyr Ser Ser Ser Asp Gly Arg Thr 
        195                 200                 205             


Trp Glu Thr Arg Val Gln Leu Ala Ala His Pro Ser His Ala Gly Glu 
    210                 215                 220                 


Met Thr Pro Val Arg Trp Thr Glu Ser Ala Gly Val Gly Arg Ala Glu 
225                 230                 235                 240 


Leu Leu Ile Thr Val Asp Ala Gly Gly Ala Ala Glu Trp Thr Leu Thr 
                245                 250                 255     


Val Arg Pro Glu Val Arg Gly Gly Thr Glu Phe Pro Ala Ala Gly Glu 
            260                 265                 270         


Thr Gly Ile Gly Leu Ser Val Ser Glu Asn Val Ser Ser His Pro Arg 
        275                 280                 285             


Gly Asn Ala Ala Glu Gly Leu Arg Ser Arg Pro Ala Arg Asn Ala Glu 
    290                 295                 300                 


Asp Asp Ala Ser Ser Ala Arg Gly Trp Leu Asn Gly Ala Pro Thr Val 
305                 310                 315                 320 


Ser Gly His Glu Ala Phe Gly Arg Trp Tyr Glu Gln Gly Met Arg Asp 
                325                 330                 335     


Ile Arg Met Leu Gln Ser Asp Phe Gly Phe Gly Pro Phe Leu Val Ala 
            340                 345                 350         


Gly Val Pro Trp Tyr Ala Val Pro Phe Gly Arg Asp Ser Leu Ile Ala 
        355                 360                 365             


Ala Arg Gln Ile Leu Ser Ala Ala Pro Glu Val Ala Arg Gly Thr Leu 
    370                 375                 380                 


Ala Thr Leu Ala His Phe Gln Gly Glu Arg Val Asp Thr Glu Arg Asp 
385                 390                 395                 400 


Glu Gln Pro Gly Lys Ile Leu His Glu Leu Arg Asp Gly Glu Leu Ala 
                405                 410                 415     


Arg Ser Gly Lys Val Pro Phe Arg Pro Tyr Tyr Gly Ser Ile Asp Ala 
            420                 425                 430         


Thr Pro Leu Phe Leu Ile Leu Leu Ala Asp Tyr Trp Arg Phe Thr Gly 
        435                 440                 445             


Asp Thr Pro Phe Leu Thr Arg Met Leu Pro His Ala Glu Arg Ala Leu 
    450                 455                 460                 


Ala Trp Met Ala Asp Tyr Gly Asp Arg Asp Gly Asp Gly Phe Ile Glu 
465                 470                 475                 480 


Tyr Trp Arg Glu Ala Glu Gly Gly Ile Ala Asn Gln Gly Trp Lys Asp 
                485                 490                 495     


Ser Gly Asp Ser Met Val His Ala Asp Gly Ser Leu Ala Gln Gly Pro 
            500                 505                 510         


Ile Ala Leu Ala Glu Val Gln Ala Tyr Ala Tyr Met Ala Tyr Val Ala 
        515                 520                 525             


Trp Arg Glu Ile Tyr Arg Glu Leu Gly Glu Pro Glu Glu Ala Glu Arg 
    530                 535                 540                 


Leu Ala Arg Leu Ala Asp Gly Leu Arg Ser Arg Phe Leu Gln His Phe 
545                 550                 555                 560 


Trp Leu Glu Glu Arg Asn Glu Ile Ala Met Ala Leu Asp Gly Asn Lys 
                565                 570                 575     


Arg Pro Leu Cys Val Ala Ser Ser Asn Met Gly Gln Val Leu Trp Ser 
            580                 585                 590         


Asp Ile Leu Pro Ser Glu Val Ala Glu Arg Val Ala Lys Arg Leu Leu 
        595                 600                 605             


Gln Pro Asp Leu Phe Ser Gly Phe Gly Ile Arg Thr Leu Ser Ala Lys 
    610                 615                 620                 


Glu Leu Arg Tyr Asn Pro Met Ser Tyr His Asn Gly Ser Val Trp Pro 
625                 630                 635                 640 


His Asp Thr Ser Leu Val Phe Ala Gly Leu Val Arg His Gly Ala Trp 
                645                 650                 655     


Glu Glu Ala Glu Gln Ile Phe Glu Gly Leu Met Arg Ala Gln Ala Gln 
            660                 665                 670         


Phe Pro His His Arg Leu Pro Glu Leu Phe Cys Gly Phe Ser Arg Glu 
        675                 680                 685             


Glu Ser Pro Arg Pro Val Pro Tyr Pro Val Ser Cys Ser Pro Gln Ala 
    690                 695                 700                 


Trp Ala Ala Ala Val Pro Ala Ile Val Leu Glu Asn Leu Leu Gly Leu 
705                 710                 715                 720 


Arg Pro Asp Ala Pro Arg Gly Glu Leu Thr Ile Phe Pro Arg Leu Pro 
                725                 730                 735     


Ala Ser Met Gln Glu Leu Lys Val His Gly Leu Arg Leu Gly Arg Gly 
            740                 745                 750         


Lys Leu Ser Val Glu Ile Ala Arg Arg Asp Gly Cys Val Leu Val Asp 
        755                 760                 765             


Val Val Glu Asn Thr Thr Gly Leu Arg Val Asp Val Met Asp Gly Ala 
    770                 775                 780                 


Lys Glu Val Met Ser Ala Ser 
785                 790     


<210>  234
<211>  791
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:219 and encoded by SEQ ID NO:229

<400>  234

Met Arg Trp Ala Ala Lys Arg Pro Arg Cys Ser Ser Ile Cys Cys Lys 
1               5                   10                  15      


Arg Ala Arg Cys His Gln Ala Arg Cys Cys Arg Arg Asn Ser Ser Cys 
            20                  25                  30          


Ala Arg Arg Pro Glu His Phe Asn Trp Gly Arg Gly Ile Met His Gly 
        35                  40                  45              


Trp Val Ile Lys Glu Asn Asp Leu Phe Trp Tyr Gly Asp Ala Glu Gly 
    50                  55                  60                  


Leu Ser Ala His Gly Val Glu Asn Val Ser Gly His Gly Leu Tyr Thr 
65                  70                  75                  80  


Arg Asp Thr Arg Val Leu Ser Ala Leu Val Trp Arg Ile Glu Pro Asp 
                85                  90                  95      


Val Trp Val Ala Leu Asp Ala Leu Ala Glu Ser Gly Ser Glu Ser Val 
            100                 105                 110         


Tyr Arg Tyr Thr Asn Arg Pro Pro Arg Ala Asp His Glu Pro Pro Arg 
        115                 120                 125             


Glu Ser Leu Leu Val Glu Arg Arg Gln Arg Val Asp Gly His Cys Phe 
    130                 135                 140                 


Gln Glu Ser Gly Ile Val Arg Asn Phe Gly Asp Arg Ala Val Arg Leu 
145                 150                 155                 160 


Ala Val Ile Tyr Glu Val Ala Ala Asp Phe Ala Asp Met Phe Glu Val 
                165                 170                 175     


Arg Gly Phe Gln Val Glu Ala Pro Ala Arg Ala Ile Arg Ser Arg Val 
            180                 185                 190         


Ser Gly Asn Val Cys Gly Phe Ser Tyr Ser Ser Ser Asp Gly Arg Thr 
        195                 200                 205             


Trp Glu Thr Arg Val Gln Leu Ala Ala His Pro Ser His Ala Gly Glu 
    210                 215                 220                 


Met Thr Pro Val Arg Trp Thr Glu Ser Ala Gly Val Gly Arg Ala Glu 
225                 230                 235                 240 


Leu Leu Ile Thr Val Asp Ala Gly Gly Ala Ala Glu Trp Thr Leu Thr 
                245                 250                 255     


Val Arg Pro Glu Val Arg Gly Gly Thr Glu Phe Pro Ala Ala Gly Glu 
            260                 265                 270         


Thr Gly Ile Gly Leu Ser Val Ser Glu Asn Val Ser Ser His Pro Arg 
        275                 280                 285             


Gly Asn Ala Ala Glu Gly Leu Arg Ser Arg Pro Ala Arg Asn Ala Glu 
    290                 295                 300                 


Asp Asp Ala Ser Ser Ala Arg Gly Trp Leu Asn Gly Ala Pro Thr Val 
305                 310                 315                 320 


Ser Gly His Glu Ala Phe Gly Arg Trp Tyr Glu Gln Gly Met Arg Asp 
                325                 330                 335     


Ile Arg Met Leu Gln Ser Asp Phe Gly Phe Gly Pro Phe Leu Val Ala 
            340                 345                 350         


Gly Val Pro Trp Tyr Ala Val Pro Phe Gly Arg Asp Ser Leu Ile Ala 
        355                 360                 365             


Ala Arg Gln Ile Leu Ser Ala Ala Pro Glu Val Ala Arg Gly Thr Leu 
    370                 375                 380                 


Ala Thr Leu Ala His Phe Gln Gly Glu Arg Val Asp Thr Glu Arg Asp 
385                 390                 395                 400 


Glu Gln Pro Gly Lys Ile Leu His Glu Leu Arg Asp Gly Glu Leu Ala 
                405                 410                 415     


Arg Ser Gly Lys Val Pro Phe Arg Pro Tyr Tyr Gly Ser Ile Asp Ala 
            420                 425                 430         


Thr Pro Leu Phe Leu Ile Leu Leu Ala Asp Tyr Trp Arg Phe Thr Gly 
        435                 440                 445             


Asp Thr Pro Phe Leu Thr Arg Met Leu Pro His Ala Glu Arg Ala Leu 
    450                 455                 460                 


Ala Trp Met Ala Asp Tyr Gly Asp Arg Asp Gly Asp Gly Phe Ile Glu 
465                 470                 475                 480 


Tyr Trp Arg Glu Ala Glu Gly Gly Ile Ala Asn Gln Gly Trp Lys Asp 
                485                 490                 495     


Ser Gly Asp Ser Met Val His Ala Asp Gly Ser Leu Ala Gln Gly Pro 
            500                 505                 510         


Ile Ala Leu Ala Glu Val Gln Ala Tyr Ala Tyr Met Ala Tyr Val Ala 
        515                 520                 525             


Trp Arg Glu Ile Tyr Arg Glu Leu Gly Glu Pro Glu Glu Ala Glu Arg 
    530                 535                 540                 


Leu Ala Arg Leu Ala Asp Gly Leu Arg Ser Arg Phe Leu Gln His Phe 
545                 550                 555                 560 


Trp Leu Glu Glu Arg Asn Glu Ile Ala Met Ala Leu Asp Gly Asn Lys 
                565                 570                 575     


Arg Pro Leu Cys Val Ala Ser Ser Asn Met Gly Gln Val Leu Trp Ser 
            580                 585                 590         


Asp Ile Leu Pro Ser Glu Val Ala Glu Arg Val Ala Lys Arg Leu Leu 
        595                 600                 605             


Gln Pro Asp Leu Phe Ser Gly Phe Gly Ile Arg Thr Leu Ser Ala Lys 
    610                 615                 620                 


Glu Leu Arg Tyr Asn Pro Met Ser Tyr His Asn Gly Ser Val Trp Pro 
625                 630                 635                 640 


His Asp Thr Ser Leu Val Phe Ala Gly Leu Val Arg His Gly Ala Trp 
                645                 650                 655     


Glu Glu Ala Glu Gln Ile Phe Glu Gly Leu Met Arg Ala Gln Ala Gln 
            660                 665                 670         


Phe Pro His His Arg Leu Pro Glu Leu Phe Cys Gly Phe Ser Arg Glu 
        675                 680                 685             


Glu Ser Pro Arg Pro Val Pro Tyr Pro Val Ser Cys Ser Pro Gln Ala 
    690                 695                 700                 


Trp Ala Ala Ala Val Pro Ala Ile Val Leu Glu Asn Leu Leu Gly Leu 
705                 710                 715                 720 


Arg Pro Asp Ala Pro Arg Gly Glu Leu Thr Ile Phe Pro Arg Leu Pro 
                725                 730                 735     


Ala Ser Met Gln Glu Leu Lys Val His Gly Leu Arg Leu Gly Arg Gly 
            740                 745                 750         


Lys Leu Ser Val Glu Ile Ala Arg Arg Asp Gly Cys Val Leu Val Asp 
        755                 760                 765             


Val Val Glu Asn Thr Thr Gly Leu Arg Val Asp Val Met Asp Gly Ala 
    770                 775                 780                 


Lys Glu Val Met Ser Ala Ser 
785                 790     


<210>  235
<211>  1083
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  235
atgcatccac atgtcgaagt cttgcgcgat ctctgcgacg cccatggaat ctcgggctac     60

gaatccggcg tccgcaagct gttcgaagag cgcctcaggc cgctttccga ggaactgttg    120

cgcgatcgca ccggcggtgt ggtcggacgc aagacgggcg atccgaatgg acccaaggtg    180

ctcatcgctg gccacctcga tgaaatcggc ttcatggtca cgcacatcac ctccgagggg    240

ttcctgaagt tccagcccat cggcgggtgg tggtcgcagg tcgtgctggc gcagcgcgtc    300

atcgtgcaaa cgcgcaaggg accgctgctc ggggtgacgg gttcgaaacc tccccacatt    360

ttgccggcgg acgagcgaaa gaaggtggtc gagctcaagg acgtgttcgt ggacatcggg    420

gccacgagca aggagcacgc agaggaaatg ggcgtgcgcc cgggcgacgc catcgtcccg    480

tactccccgt tcacgcagct cggcaatccg aagatgtacg tgtcgaaggc gctcgacaac    540

cggctcggct gcgccaccgc gctctgcgtg ttgaaggaac tgcaagggca ggcccatccg    600

aacatcgtgt ttgcaggcgc cacggcccag gaggaggtcg gcctgcgcgg cgcgaaaacg    660

ctcgtccatc tggtcgatcc ggacatcgcg atctcgatcg acgtcggcgt ggccggcgac    720

acgcccggga ttgagagcgg ggagcgccag cacctcggcg acgcgggcaa ggggccgctg    780

ctcatgattt acgatcactc catgatcccg aacaaccgct tccgcgattt cgtgctggac    840

atcgccgcga cggaaaacat ccccgtccaa ctcagcagcc tggccggcgg aggtacggac    900

gcgggatcgt tccacctgca cggcatcggc gtgccgagcg tcaacatcgg cttcgcgacg    960

cgctacatcc acagccacaa cggtgtcgtg cacgaggacg actatctcca ggcgattcgg   1020

cttgtcaccg ccatggtgaa ggcgctggac aaggatatgg tcaccgaaat tcaggcgtgg   1080

taa                                                                 1083


<210>  236
<211>  360
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  236

Met His Pro His Val Glu Val Leu Arg Asp Leu Cys Asp Ala His Gly 
1               5                   10                  15      


Ile Ser Gly Tyr Glu Ser Gly Val Arg Lys Leu Phe Glu Glu Arg Leu 
            20                  25                  30          


Arg Pro Leu Ser Glu Glu Leu Leu Arg Asp Arg Thr Gly Gly Val Val 
        35                  40                  45              


Gly Arg Lys Thr Gly Asp Pro Asn Gly Pro Lys Val Leu Ile Ala Gly 
    50                  55                  60                  


His Leu Asp Glu Ile Gly Phe Met Val Thr His Ile Thr Ser Glu Gly 
65                  70                  75                  80  


Phe Leu Lys Phe Gln Pro Ile Gly Gly Trp Trp Ser Gln Val Val Leu 
                85                  90                  95      


Ala Gln Arg Val Ile Val Gln Thr Arg Lys Gly Pro Leu Leu Gly Val 
            100                 105                 110         


Thr Gly Ser Lys Pro Pro His Ile Leu Pro Ala Asp Glu Arg Lys Lys 
        115                 120                 125             


Val Val Glu Leu Lys Asp Val Phe Val Asp Ile Gly Ala Thr Ser Lys 
    130                 135                 140                 


Glu His Ala Glu Glu Met Gly Val Arg Pro Gly Asp Ala Ile Val Pro 
145                 150                 155                 160 


Tyr Ser Pro Phe Thr Gln Leu Gly Asn Pro Lys Met Tyr Val Ser Lys 
                165                 170                 175     


Ala Leu Asp Asn Arg Leu Gly Cys Ala Thr Ala Leu Cys Val Leu Lys 
            180                 185                 190         


Glu Leu Gln Gly Gln Ala His Pro Asn Ile Val Phe Ala Gly Ala Thr 
        195                 200                 205             


Ala Gln Glu Glu Val Gly Leu Arg Gly Ala Lys Thr Leu Val His Leu 
    210                 215                 220                 


Val Asp Pro Asp Ile Ala Ile Ser Ile Asp Val Gly Val Ala Gly Asp 
225                 230                 235                 240 


Thr Pro Gly Ile Glu Ser Gly Glu Arg Gln His Leu Gly Asp Ala Gly 
                245                 250                 255     


Lys Gly Pro Leu Leu Met Ile Tyr Asp His Ser Met Ile Pro Asn Asn 
            260                 265                 270         


Arg Phe Arg Asp Phe Val Leu Asp Ile Ala Ala Thr Glu Asn Ile Pro 
        275                 280                 285             


Val Gln Leu Ser Ser Leu Ala Gly Gly Gly Thr Asp Ala Gly Ser Phe 
    290                 295                 300                 


His Leu His Gly Ile Gly Val Pro Ser Val Asn Ile Gly Phe Ala Thr 
305                 310                 315                 320 


Arg Tyr Ile His Ser His Asn Gly Val Val His Glu Asp Asp Tyr Leu 
                325                 330                 335     


Gln Ala Ile Arg Leu Val Thr Ala Met Val Lys Ala Leu Asp Lys Asp 
            340                 345                 350         


Met Val Thr Glu Ile Gln Ala Trp 
        355                 360 


<210>  237
<211>  361
<212>  PRT
<213>  Bacillus licheniformis

<400>  237

Met Ala Lys Leu Asp Glu Thr Leu Met Met Leu Lys Glu Leu Thr Asp 
1               5                   10                  15      


Ala Lys Gly Ile Pro Ala Asn Glu Lys Glu Pro Arg Gln Val Met Lys 
            20                  25                  30          


Ser Tyr Ile Glu Pro Phe Ala Asp Glu Val Thr Thr Asp Arg Leu Gly 
        35                  40                  45              


Ser Leu Ile Ala Lys Lys Thr Gly Gln Ala Asp Gly Pro Lys Ile Met 
    50                  55                  60                  


Ile Ala Gly His Leu Asp Glu Val Gly Phe Met Val Thr Arg Ile Asp 
65                  70                  75                  80  


Asp Arg Gly Tyr Leu Arg Phe Gln Thr Val Gly Gly Trp Trp Ser Gln 
                85                  90                  95      


Val Met Leu Ala Gln Arg Val Thr Val Val Thr Lys Lys Gly Asp Ile 
            100                 105                 110         


Thr Gly Ile Ile Gly Ser Lys Pro Pro His Val Leu Ser Gln Glu Ala 
        115                 120                 125             


Arg Lys Lys Ser Val Asp Ile Lys Asp Met Phe Ile Asp Ile Gly Ala 
    130                 135                 140                 


Ser Ser Arg Glu Glu Ala Met Glu Trp Gly Val Leu Pro Gly Asp Gln 
145                 150                 155                 160 


Val Val Pro Tyr Phe Glu Phe Thr Val Met Asn Asn Glu Lys Met Leu 
                165                 170                 175     


Leu Ala Lys Ala Trp Asp Asn Arg Ile Gly Cys Ala Ile Ala Ile Asp 
            180                 185                 190         


Val Leu Lys Asn Leu Lys Gly Ala Asp His Pro Asn Val Val Tyr Gly 
        195                 200                 205             


Val Gly Thr Val Gln Glu Glu Val Gly Leu Arg Gly Ala Lys Thr Ala 
    210                 215                 220                 


Ala His Thr Ile Lys Pro Asp Ile Ala Phe Gly Val Asp Val Gly Ile 
225                 230                 235                 240 


Ala Gly Asp Thr Pro Gly Ile Thr Glu Lys Glu Ser Ala Ser Lys Met 
                245                 250                 255     


Gly Lys Gly Pro Gln Ile Ile Leu Tyr Asp Ala Ser Met Val Ser His 
            260                 265                 270         


Lys Gly Leu Arg Asp Phe Val Thr Asn Val Ala Asp Glu Ala Gly Ile 
        275                 280                 285             


Pro Tyr Gln Phe Asp Ala Leu Ser Gly Gly Gly Thr Asp Ser Gly Ser 
    290                 295                 300                 


Ile His Leu Thr Ala Asn Gly Val Pro Ala Leu Ser Ile Thr Ile Ala 
305                 310                 315                 320 


Thr Arg Tyr Ile His Thr His Ala Ala Met Leu His Arg Asp Asp Tyr 
                325                 330                 335     


Glu His Ala Val Lys Leu Ile Thr Glu Val Ile Lys Arg Leu Asp Lys 
            340                 345                 350         


Glu Thr Val Gln Asn Ile Thr Phe Asp 
        355                 360     


<210>  238
<211>  361
<212>  PRT
<213>  Bacillus coagulans

<400>  238

Met Ala Lys Leu Asp Glu Thr Leu Ser Met Leu Lys Asp Leu Thr Asp 
1               5                   10                  15      


Ala Lys Gly Ile Ala Gly Asn Glu Ala Glu Val Arg Ala Val Val Lys 
            20                  25                  30          


Lys Tyr Ile Glu Pro Tyr Ala Asp Glu Leu Asp Thr Asp Gly Leu Gly 
        35                  40                  45              


Ser Leu Ile Ala Lys Lys Thr Gly Gln Ala Asp Gly Pro Lys Ile Met 
    50                  55                  60                  


Ile Ala Gly His Met Asp Glu Val Gly Phe Met Val Thr Gln Ile Asp 
65                  70                  75                  80  


Glu Ser Gly Phe Leu Arg Phe Gln Thr Ile Gly Gly Trp Trp Ser Gln 
                85                  90                  95      


Val Met Leu Ala Gln Arg Val Thr Val Val Thr Asp Lys Gly Asp Val 
            100                 105                 110         


Thr Gly Val Ile Gly Ser Lys Pro Pro His Ile Leu Ser Pro Asp Ala 
        115                 120                 125             


Arg Lys Lys Ser Tyr Glu Ile Lys Asp Met Phe Ile Asp Ile Gly Ala 
    130                 135                 140                 


Thr Ser Arg Glu Glu Ala Leu Glu Trp Gly Val Lys Pro Gly Asp Met 
145                 150                 155                 160 


Val Val Pro Tyr Phe Glu Phe Thr Val Met Lys Asn Glu Lys Met Leu 
                165                 170                 175     


Leu Ala Lys Ala Trp Asp Asn Arg Ile Gly Cys Ala Val Val Ile Asp 
            180                 185                 190         


Val Leu Lys Asn Leu His Lys Glu Asn His Pro Asn Ile Val Tyr Gly 
        195                 200                 205             


Val Thr Asn Val Gln Glu Glu Val Gly Leu Arg Gly Ala Lys Thr Ala 
    210                 215                 220                 


Ala Ser Lys Val Lys Pro Asp Ile Ala Phe Ala Leu Asp Val Gly Ile 
225                 230                 235                 240 


Ala Gly Asp Thr Pro Gly Ile Ser Glu Lys Glu Ala Leu Ser Lys Met 
                245                 250                 255     


Gly Lys Gly Pro Gln Ile Val Ile Tyr Asp Ala Ser Met Val Ala His 
            260                 265                 270         


Lys Gly Leu Arg Asp Thr Val Val Lys Val Ala Glu Glu Leu Asn Ile 
        275                 280                 285             


Pro Tyr Gln Phe Glu Ser Ile Pro Gly Gly Gly Thr Asp Ala Gly Ser 
    290                 295                 300                 


Ile His Leu Thr Gly Ser Gly Ile Pro Ser Leu Ala Ile Thr Ile Ala 
305                 310                 315                 320 


Thr Arg Tyr Ile His Ser His Ala Gly Ile Leu His Arg Asp Asp Tyr 
                325                 330                 335     


Glu Asn Thr Val Lys Leu Ile Thr Glu Val Ile Lys Arg Leu Asp Arg 
            340                 345                 350         


Lys Thr Val Asn His Ile Ile Phe Asp 
        355                 360     


<210>  239
<211>  361
<212>  PRT
<213>  Bacillus NRRL B-14911

<400>  239

Met Ala Lys Leu Asp Glu Thr Leu Thr Met Leu Lys Glu Leu Thr Asp 
1               5                   10                  15      


Ala Lys Gly Ile Pro Gly Asn Glu Arg Glu Val Arg Glu Val Met Lys 
            20                  25                  30          


Lys Tyr Ile Thr Glu Phe Ala Asp Glu Val Thr Thr Asp Gly Leu Gly 
        35                  40                  45              


Ser Leu Val Ala Lys Lys Thr Gly Lys Glu Gly Gly Pro Lys Ile Met 
    50                  55                  60                  


Val Ala Gly His Leu Asp Glu Val Gly Phe Met Ile Thr Ser Ile Asp 
65                  70                  75                  80  


Asp Lys Gly Phe Leu Arg Phe Gln Thr Val Gly Gly Trp Trp Ser Gln 
                85                  90                  95      


Val Met Leu Ala Gln Arg Val Thr Ile Val Thr Ser Lys Gly Asp Val 
            100                 105                 110         


Thr Gly Ile Ile Gly Ser Lys Pro Pro His Ile Leu Pro Pro Glu Ala 
        115                 120                 125             


Arg Lys Lys Pro Val Asp Ile Lys Asp Met Phe Ile Asp Ile Gly Ala 
    130                 135                 140                 


Ser Ser Arg Glu Glu Ala Met Glu Trp Gly Val Lys Pro Gly Asp Met 
145                 150                 155                 160 


Ala Val Pro Tyr Phe Glu Phe Thr Val Met Asn Asn Glu Lys Met Leu 
                165                 170                 175     


Leu Ala Lys Ala Trp Asp Asn Arg Ile Gly Cys Ala Ile Ala Ile Asp 
            180                 185                 190         


Val Leu Lys Gln Leu Lys Asp Ala Glu His Pro Asn Val Val Tyr Gly 
        195                 200                 205             


Val Gly Thr Val Gln Glu Glu Val Gly Leu Arg Gly Ala Lys Thr Ala 
    210                 215                 220                 


Ala Asn Leu Ile Glu Pro Asp Ile Gly Phe Gly Val Asp Val Gly Ile 
225                 230                 235                 240 


Ala Gly Asp Thr Pro Gly Ile Ser Glu Lys Glu Ala Leu Ser Lys Met 
                245                 250                 255     


Gly Lys Gly Pro Gln Ile Ile Leu Tyr Asp Ala Ser Leu Val Ser His 
            260                 265                 270         


Lys Gly Leu Arg Asp Leu Val Thr Asp Thr Ala Asp Glu Met Asn Ile 
        275                 280                 285             


Pro Tyr Gln Phe Asp Ser Ile Ala Gly Gly Gly Ala Asp Ser Gly Ala 
    290                 295                 300                 


Ile His Leu Ser His Asn Gly Val Pro Ser Leu Ala Ile Thr Ile Ala 
305                 310                 315                 320 


Thr Arg Tyr Ile His Ser His Ala Ala Met Leu His Arg Asp Asp Tyr 
                325                 330                 335     


Glu Asn Ala Val Lys Leu Ile Val Glu Val Ile Lys Arg Leu Asp Lys 
            340                 345                 350         


Glu Thr Val Asp Arg Ile Thr Phe Asp 
        355                 360     


<210>  240
<211>  357
<212>  PRT
<213>  Thermosinus carboxydivorans

<400>  240

Met Asp Lys Thr Leu Ala Trp Leu Lys Glu Ile Ser Glu Ala Pro Gly 
1               5                   10                  15      


Val Ser Gly Phe Glu Gln Pro Ile Arg Thr Leu Leu Thr Gln Lys Leu 
            20                  25                  30          


Ser Ser Ile Ala Glu Val Ser Ser Asp Asn Leu Gly Ser Val Ile Phe 
        35                  40                  45              


Lys Lys Arg Gly Gly Ser Asp Thr Pro Lys Ile Met Ile Ala Ala His 
    50                  55                  60                  


Met Asp Glu Ile Gly Phe Met Val Lys Tyr Ile Thr Lys Glu Gly Phe 
65                  70                  75                  80  


Leu Lys Phe Thr Thr Leu Gly Gly Trp Trp Glu Gln Val Met Leu Gly 
                85                  90                  95      


Gln Arg Val Thr Val His Thr Thr Lys Gly Ala Ile Pro Gly Val Ile 
            100                 105                 110         


Gly Ser Lys Pro Pro His Ile Leu Ser Pro Glu Glu Arg Lys Lys Val 
        115                 120                 125             


Val Gln Lys Lys Asp Met Tyr Ile Asp Ile Gly Ala Glu Asp Glu Lys 
    130                 135                 140                 


Glu Ala Lys Glu Arg Phe Gly Val Arg Pro Gly Asn Pro Val Thr Pro 
145                 150                 155                 160 


Phe Ser Pro Phe Thr Thr Leu Ala Asn Glu Arg Leu Leu Met Gly Lys 
                165                 170                 175     


Ala Trp Asp Asn Arg Ile Gly Cys Ala Ile Met Ala Glu Val Met Glu 
            180                 185                 190         


Lys Leu Gln His Glu Met His Ala Asn Thr Val Tyr Gly Val Gly Thr 
        195                 200                 205             


Val Gln Glu Glu Val Gly Leu Arg Gly Ala Lys Thr Ser Ala Gly Val 
    210                 215                 220                 


Ile His Pro Asp Ile Ala Phe Ala Val Asp Thr Cys Val Ala Gly Asp 
225                 230                 235                 240 


Thr Pro Gly Val Thr Ser Asp Gln Ala Ser Ser Lys Leu Gly Lys Gly 
                245                 250                 255     


Val Ala Ile Ser Ile Tyr Asp Ser Ser Leu Ile Pro His Thr Gly Leu 
            260                 265                 270         


Arg Asp Phe Val Val Glu Val Ala Glu Gln Asn His Ile Pro Tyr Gln 
        275                 280                 285             


Leu Glu Phe Thr Glu Gly Gly Gly Thr Asp Ala Gly Arg Ile His Leu 
    290                 295                 300                 


His Ala Gln Gly Val Pro Ser Leu Val Leu Ser Ile Pro Thr Arg Tyr 
305                 310                 315                 320 


Ile His Ser His Asn Ser Ile Val His Arg Asp Asp Tyr Asp Ala Ala 
                325                 330                 335     


Val Arg Leu Leu Val Ala Val Ile Lys Gln Leu Asp Gln Asn Lys Tyr 
            340                 345                 350         


Gln Glu Leu Val Lys 
        355         


<210>  241
<211>  357
<212>  PRT
<213>  Bacillus halodurans

<400>  241

Met Asn Gln Glu Thr Gln Ser Leu Phe Lys Thr Leu Thr Glu Leu Gln 
1               5                   10                  15      


Gly Ala Pro Gly Phe Glu His His Ile Arg Arg Phe Val Arg Gly Glu 
            20                  25                  30          


Leu Glu Lys Tyr Thr Asn Glu Ile Val Gln Asp Arg Leu Gly Ser Ile 
        35                  40                  45              


Phe Gly Val Lys Arg Gly Asn Glu Gln Gly Pro Lys Val Met Val Ala 
    50                  55                  60                  


Gly His Met Asp Glu Val Gly Phe Met Val Thr Ser Ile Asn Glu Lys 
65                  70                  75                  80  


Gly Leu Ile Arg Phe Gln Thr Leu Gly Gly Trp Trp Ser Gln Val Leu 
                85                  90                  95      


Leu Ala Gln Arg Val Gln Ile Met Thr Asp Glu Gly Pro Val Ile Gly 
            100                 105                 110         


Val Ile Gly Ser Thr Pro Pro His Leu Leu Glu Glu Ala Gln Arg Lys 
        115                 120                 125             


Lys Pro Met Asp Val Lys Asn Met Tyr Ile Asp Ile Gly Ala Asp Asp 
    130                 135                 140                 


Lys Glu Asp Ala Gln Lys Ile Gly Ile Lys Pro Gly Gln Gln Ile Val 
145                 150                 155                 160 


Pro Ile Cys Pro Phe Thr Pro Leu Ala Asn Glu Lys Lys Ile Met Ala 
                165                 170                 175     


Lys Ala Trp Asp Asn Arg Tyr Gly Val Gly Leu Ala Ile Glu Leu Leu 
            180                 185                 190         


Lys Glu Leu Gln Gly Glu Thr Thr Pro Asn Ile Leu Tyr Ser Gly Ala 
        195                 200                 205             


Thr Val Gln Glu Glu Val Gly Leu Arg Gly Ala Ala Thr Ser Ala Gln 
    210                 215                 220                 


Met Ile Glu Pro Asp Ile Phe Tyr Ala Leu Asp Ala Ser Pro Ala Asn 
225                 230                 235                 240 


Asp Ala Thr Ala Gly Lys Asp Ala Phe Gly Gln Leu Gly Lys Gly Ala 
                245                 250                 255     


Leu Val Arg Ile Tyr Asp Arg Thr Met Val Thr His Arg Gly Ile Arg 
            260                 265                 270         


Asp Phe Val Leu Asp Thr Ala Glu Thr Glu Asn Ile Pro Tyr Gln Phe 
        275                 280                 285             


Phe Ile Ser Gln Gly Gly Thr Asp Ala Gly Arg Val His Leu Ser Gly 
    290                 295                 300                 


Asn Gly Val Pro Ser Ala Val Ile Gly Ile Cys Ser Arg Tyr Ile His 
305                 310                 315                 320 


Thr Ala Ala Ser Ile Ile His Val Asp Asp Tyr Ala Ala Ala Lys Ala 
                325                 330                 335     


Leu Leu Val Lys Leu Val Lys Thr Thr Asp Lys Ala Ala Val Glu Thr 
            340                 345                 350         


Ile Leu Ala Asn Gly 
        355         


<210>  242
<211>  1083
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 235

<400>  242
atgcatccac atatcgaagt cttgcgcgat ctctgcgacg cccatggaat ctcgggctac     60

gaatccggcg tccgcaagct gttcgaagag cgcctcaggc cgctttccga ggaactgttg    120

cgcgatcgca ccggcggtgt ggtcggacgc aagacgggcg atccgaatgg acccaaggtg    180

ctcatcgctg gccacctcga tgaaatcggc ttcatggtca cgcacatcac ctccgagggg    240

ttcctgaagt tccagcccat cggcgggtgg tggtcgcagg tcgtgctggc gcagcgcgtc    300

atcgtgcaaa cgcgcaaggg accgctgctc ggggtgacgg gttcgaaacc tccccacatt    360

ttgccggcgg acgagcgaaa gaaggtggtc gagctcaagg acgtgttcgt ggacatcggg    420

gccacgagca aggagcacgc agaggaaatg ggcgtgcgcc cgggcgacgc catcgtcccg    480

tactccccgt tcacgcagct cggcaatccg aagatgtacg tgtcgaaggc gctcgacaac    540

cggctcggct gcgccaccgc gctctgcgtg ttgaaggaac tgcaagggca ggcccatccg    600

aacatcgtgt ttgcaggcgc cacggcccag gaggaggtcg gcctgcgcgg cgcgaaaacg    660

ctcgtccatc tggtcgatcc ggacatcgcg atctcgatcg acgtcggcgt ggccggcgac    720

acgcccggga ttgagagcgg ggagcgccag cacctcggcg acgcgggcaa ggggccgctg    780

ctcatgattt acgatcactc catgatcccg aacaaccgct tccgcgattt cgtgctggac    840

atcgccgcga cggaaaacat ccccgtccaa ctcagcagcc tggccggcgg aggtacggac    900

gcgggatcgt tccacctgca cggcatcggc gtgccgagcg tcaacatcgg cttcgcgacg    960

cgctacatcc acagccacaa cggtgtcgtg cacgaggacg actatctcca ggcgattcgg   1020

cttgtcaccg ccatggtgaa ggcgctggac aaggatatgg tcaccgaaat tcaggcgtgg   1080

taa                                                                 1083


<210>  243
<211>  1083
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 235

<400>  243
atgcatccac atctcgaagt cttgcgcgat ctctgcgacg cccatggaat ctcgggctac     60

gaatccggcg tccgcaagct gttcgaagag cgcctcaggc cgctttccga ggaactgttg    120

cgcgatcgca ccggcggtgt ggtcggacgc aagacgggcg atccgaatgg acccaaggtg    180

ctcatcgctg gccacctcga tgaaatcggc ttcatggtca cgcacatcac ctccgagggg    240

ttcctgaagt tccagcccat cggcgggtgg tggtcgcagg tcgtgctggc gcagcgcgtc    300

atcgtgcaaa cgcgcaaggg accgctgctc ggggtgacgg gttcgaaacc tccccacatt    360

ttgccggcgg acgagcgaaa gaaggtggtc gagctcaagg acgtgttcgt ggacatcggg    420

gccacgagca aggagcacgc agaggaaatg ggcgtgcgcc cgggcgacgc catcgtcccg    480

tactccccgt tcacgcagct cggcaatccg aagatgtacg tgtcgaaggc gctcgacaac    540

cggctcggct gcgccaccgc gctctgcgtg ttgaaggaac tgcaagggca ggcccatccg    600

aacatcgtgt ttgcaggcgc cacggcccag gaggaggtcg gcctgcgcgg cgcgaaaacg    660

ctcgtccatc tggtcgatcc ggacatcgcg atctcgatcg acgtcggcgt ggccggcgac    720

acgcccggga ttgagagcgg ggagcgccag cacctcggcg acgcgggcaa ggggccgctg    780

ctcatgattt acgatcactc catgatcccg aacaaccgct tccgcgattt cgtgctggac    840

atcgccgcga cggaaaacat ccccgtccaa ctcagcagcc tggccggcgg aggtacggac    900

gcgggatcgt tccacctgca cggcatcggc gtgccgagcg tcaacatcgg cttcgcgacg    960

cgctacatcc acagccacaa cggtgtcgtg cacgaggacg actatctcca ggcgattcgg   1020

cttgtcaccg ccatggtgaa ggcgctggac aaggatatgg tcaccgaaat tcaggcgtgg   1080

taa                                                                 1083


<210>  244
<211>  1083
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 235

<400>  244
atgcatccac atgtcgaaat cttgcgcgat ctctgcgacg cccatggaat ctcgggctac     60

gaatccggcg tccgcaagct gttcgaagag cgcctcaggc cgctttccga ggaactgttg    120

cgcgatcgca ccggcggtgt ggtcggacgc aagacgggcg atccgaatgg acccaaggtg    180

ctcatcgctg gccacctcga tgaaatcggc ttcatggtca cgcacatcac ctccgagggg    240

ttcctgaagt tccagcccat cggcgggtgg tggtcgcagg tcgtgctggc gcagcgcgtc    300

atcgtgcaaa cgcgcaaggg accgctgctc ggggtgacgg gttcgaaacc tccccacatt    360

ttgccggcgg acgagcgaaa gaaggtggtc gagctcaagg acgtgttcgt ggacatcggg    420

gccacgagca aggagcacgc agaggaaatg ggcgtgcgcc cgggcgacgc catcgtcccg    480

tactccccgt tcacgcagct cggcaatccg aagatgtacg tgtcgaaggc gctcgacaac    540

cggctcggct gcgccaccgc gctctgcgtg ttgaaggaac tgcaagggca ggcccatccg    600

aacatcgtgt ttgcaggcgc cacggcccag gaggaggtcg gcctgcgcgg cgcgaaaacg    660

ctcgtccatc tggtcgatcc ggacatcgcg atctcgatcg acgtcggcgt ggccggcgac    720

acgcccggga ttgagagcgg ggagcgccag cacctcggcg acgcgggcaa ggggccgctg    780

ctcatgattt acgatcactc catgatcccg aacaaccgct tccgcgattt cgtgctggac    840

atcgccgcga cggaaaacat ccccgtccaa ctcagcagcc tggccggcgg aggtacggac    900

gcgggatcgt tccacctgca cggcatcggc gtgccgagcg tcaacatcgg cttcgcgacg    960

cgctacatcc acagccacaa cggtgtcgtg cacgaggacg actatctcca ggcgattcgg   1020

cttgtcaccg ccatggtgaa ggcgctggac aaggatatgg tcaccgaaat tcaggcgtgg   1080

taa                                                                 1083


<210>  245
<211>  1083
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 235

<400>  245
atgcatccac atgtcgaact cttgcgcgat ctctgcgacg cccatggaat ctcgggctac     60

gaatccggcg tccgcaagct gttcgaagag cgcctcaggc cgctttccga ggaactgttg    120

cgcgatcgca ccggcggtgt ggtcggacgc aagacgggcg atccgaatgg acccaaggtg    180

ctcatcgctg gccacctcga tgaaatcggc ttcatggtca cgcacatcac ctccgagggg    240

ttcctgaagt tccagcccat cggcgggtgg tggtcgcagg tcgtgctggc gcagcgcgtc    300

atcgtgcaaa cgcgcaaggg accgctgctc ggggtgacgg gttcgaaacc tccccacatt    360

ttgccggcgg acgagcgaaa gaaggtggtc gagctcaagg acgtgttcgt ggacatcggg    420

gccacgagca aggagcacgc agaggaaatg ggcgtgcgcc cgggcgacgc catcgtcccg    480

tactccccgt tcacgcagct cggcaatccg aagatgtacg tgtcgaaggc gctcgacaac    540

cggctcggct gcgccaccgc gctctgcgtg ttgaaggaac tgcaagggca ggcccatccg    600

aacatcgtgt ttgcaggcgc cacggcccag gaggaggtcg gcctgcgcgg cgcgaaaacg    660

ctcgtccatc tggtcgatcc ggacatcgcg atctcgatcg acgtcggcgt ggccggcgac    720

acgcccggga ttgagagcgg ggagcgccag cacctcggcg acgcgggcaa ggggccgctg    780

ctcatgattt acgatcactc catgatcccg aacaaccgct tccgcgattt cgtgctggac    840

atcgccgcga cggaaaacat ccccgtccaa ctcagcagcc tggccggcgg aggtacggac    900

gcgggatcgt tccacctgca cggcatcggc gtgccgagcg tcaacatcgg cttcgcgacg    960

cgctacatcc acagccacaa cggtgtcgtg cacgaggacg actatctcca ggcgattcgg   1020

cttgtcaccg ccatggtgaa ggcgctggac aaggatatgg tcaccgaaat tcaggcgtgg   1080

taa                                                                 1083


<210>  246
<211>  1059
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 235

<400>  246
atgcatccac atgtcgaagt cttgaaagat ctctgcgacg cccatggaat ctcgggctac     60

gaatccggcg tccgcaagct gttcgaagag cgcctcaggc cgctttccga ggaactgttg    120

cgcgatcgca ccggcggtgt ggtcggacgc aagacgggcg atccgaatgg acccaaggtg    180

ctcatcgctg gccacctcga tgaaatcggc ttcatggtca cgcacatcac ctccgagggg    240

ttcctgaagt tccagcccat cggcgggtgg tggtcgcagg tcgtgctggc gcagcgcgtc    300

atcgtgcaaa cgcgcaaggg accgctgctc ggggtgacgg gttcgaaacc tccccacatt    360

ttgccggcgg acgagcgaaa gaaggtggtc gagctcaagg acgtgttcgt ggacatcggg    420

gccacgagca aggagcacgc agaggaaatg ggcgtgcgcc cgggcgacgc catcgtcccg    480

tactccccgt tcacgcagct cggcaatccg aagatgtacg tgtcgaaggc gctcgacaac    540

cggctcggct gcgccaccgc gctctgcgtg ttgaaggaac tgcaagggca ggcccatccg    600

aacatcgtgt ttgcaggcgc cacggcccag gaggaggtcg gcctgcgcgg cgcgaaaacg    660

ctcgtccatc tggtcgatcc ggacatcgcg atctcgatcg acgtcggcgt ggccggcgac    720

acgcccggga ttgagagcgg ggagcgccag cacctcggcg acgcgggcaa ggggccgctg    780

ctcatgattt acgatcactc catgatcccg aacaaccgct tccgcgattt cgtgctggac    840

atcgccgcga cggaaaacat ccccgtccaa ctcagcagcc tggccggcgg aggtacggac    900

gcgggatcgt tccacctgca cggcatcggc gtgccgagcg tcaacatcgg cttcgcgacg    960

cgctacatcc acagccacaa cggtgtcgtg cacgaggacg actatctcca ggcgattcgg   1020

cttgtcaccg ccatggtgaa ggcgctggac aaggatatg                          1059


<210>  247
<211>  360
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:236 and encoded by SEQ ID NO:242

<400>  247

Met His Pro His Ile Glu Val Leu Arg Asp Leu Cys Asp Ala His Gly 
1               5                   10                  15      


Ile Ser Gly Tyr Glu Ser Gly Val Arg Lys Leu Phe Glu Glu Arg Leu 
            20                  25                  30          


Arg Pro Leu Ser Glu Glu Leu Leu Arg Asp Arg Thr Gly Gly Val Val 
        35                  40                  45              


Gly Arg Lys Thr Gly Asp Pro Asn Gly Pro Lys Val Leu Ile Ala Gly 
    50                  55                  60                  


His Leu Asp Glu Ile Gly Phe Met Val Thr His Ile Thr Ser Glu Gly 
65                  70                  75                  80  


Phe Leu Lys Phe Gln Pro Ile Gly Gly Trp Trp Ser Gln Val Val Leu 
                85                  90                  95      


Ala Gln Arg Val Ile Val Gln Thr Arg Lys Gly Pro Leu Leu Gly Val 
            100                 105                 110         


Thr Gly Ser Lys Pro Pro His Ile Leu Pro Ala Asp Glu Arg Lys Lys 
        115                 120                 125             


Val Val Glu Leu Lys Asp Val Phe Val Asp Ile Gly Ala Thr Ser Lys 
    130                 135                 140                 


Glu His Ala Glu Glu Met Gly Val Arg Pro Gly Asp Ala Ile Val Pro 
145                 150                 155                 160 


Tyr Ser Pro Phe Thr Gln Leu Gly Asn Pro Lys Met Tyr Val Ser Lys 
                165                 170                 175     


Ala Leu Asp Asn Arg Leu Gly Cys Ala Thr Ala Leu Cys Val Leu Lys 
            180                 185                 190         


Glu Leu Gln Gly Gln Ala His Pro Asn Ile Val Phe Ala Gly Ala Thr 
        195                 200                 205             


Ala Gln Glu Glu Val Gly Leu Arg Gly Ala Lys Thr Leu Val His Leu 
    210                 215                 220                 


Val Asp Pro Asp Ile Ala Ile Ser Ile Asp Val Gly Val Ala Gly Asp 
225                 230                 235                 240 


Thr Pro Gly Ile Glu Ser Gly Glu Arg Gln His Leu Gly Asp Ala Gly 
                245                 250                 255     


Lys Gly Pro Leu Leu Met Ile Tyr Asp His Ser Met Ile Pro Asn Asn 
            260                 265                 270         


Arg Phe Arg Asp Phe Val Leu Asp Ile Ala Ala Thr Glu Asn Ile Pro 
        275                 280                 285             


Val Gln Leu Ser Ser Leu Ala Gly Gly Gly Thr Asp Ala Gly Ser Phe 
    290                 295                 300                 


His Leu His Gly Ile Gly Val Pro Ser Val Asn Ile Gly Phe Ala Thr 
305                 310                 315                 320 


Arg Tyr Ile His Ser His Asn Gly Val Val His Glu Asp Asp Tyr Leu 
                325                 330                 335     


Gln Ala Ile Arg Leu Val Thr Ala Met Val Lys Ala Leu Asp Lys Asp 
            340                 345                 350         


Met Val Thr Glu Ile Gln Ala Trp 
        355                 360 


<210>  248
<211>  360
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:236 and encoded by SEQ ID NO:243

<400>  248

Met His Pro His Leu Glu Val Leu Arg Asp Leu Cys Asp Ala His Gly 
1               5                   10                  15      


Ile Ser Gly Tyr Glu Ser Gly Val Arg Lys Leu Phe Glu Glu Arg Leu 
            20                  25                  30          


Arg Pro Leu Ser Glu Glu Leu Leu Arg Asp Arg Thr Gly Gly Val Val 
        35                  40                  45              


Gly Arg Lys Thr Gly Asp Pro Asn Gly Pro Lys Val Leu Ile Ala Gly 
    50                  55                  60                  


His Leu Asp Glu Ile Gly Phe Met Val Thr His Ile Thr Ser Glu Gly 
65                  70                  75                  80  


Phe Leu Lys Phe Gln Pro Ile Gly Gly Trp Trp Ser Gln Val Val Leu 
                85                  90                  95      


Ala Gln Arg Val Ile Val Gln Thr Arg Lys Gly Pro Leu Leu Gly Val 
            100                 105                 110         


Thr Gly Ser Lys Pro Pro His Ile Leu Pro Ala Asp Glu Arg Lys Lys 
        115                 120                 125             


Val Val Glu Leu Lys Asp Val Phe Val Asp Ile Gly Ala Thr Ser Lys 
    130                 135                 140                 


Glu His Ala Glu Glu Met Gly Val Arg Pro Gly Asp Ala Ile Val Pro 
145                 150                 155                 160 


Tyr Ser Pro Phe Thr Gln Leu Gly Asn Pro Lys Met Tyr Val Ser Lys 
                165                 170                 175     


Ala Leu Asp Asn Arg Leu Gly Cys Ala Thr Ala Leu Cys Val Leu Lys 
            180                 185                 190         


Glu Leu Gln Gly Gln Ala His Pro Asn Ile Val Phe Ala Gly Ala Thr 
        195                 200                 205             


Ala Gln Glu Glu Val Gly Leu Arg Gly Ala Lys Thr Leu Val His Leu 
    210                 215                 220                 


Val Asp Pro Asp Ile Ala Ile Ser Ile Asp Val Gly Val Ala Gly Asp 
225                 230                 235                 240 


Thr Pro Gly Ile Glu Ser Gly Glu Arg Gln His Leu Gly Asp Ala Gly 
                245                 250                 255     


Lys Gly Pro Leu Leu Met Ile Tyr Asp His Ser Met Ile Pro Asn Asn 
            260                 265                 270         


Arg Phe Arg Asp Phe Val Leu Asp Ile Ala Ala Thr Glu Asn Ile Pro 
        275                 280                 285             


Val Gln Leu Ser Ser Leu Ala Gly Gly Gly Thr Asp Ala Gly Ser Phe 
    290                 295                 300                 


His Leu His Gly Ile Gly Val Pro Ser Val Asn Ile Gly Phe Ala Thr 
305                 310                 315                 320 


Arg Tyr Ile His Ser His Asn Gly Val Val His Glu Asp Asp Tyr Leu 
                325                 330                 335     


Gln Ala Ile Arg Leu Val Thr Ala Met Val Lys Ala Leu Asp Lys Asp 
            340                 345                 350         


Met Val Thr Glu Ile Gln Ala Trp 
        355                 360 


<210>  249
<211>  360
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:236 and encoded by SEQ ID NO:244

<400>  249

Met His Pro His Val Glu Ile Leu Arg Asp Leu Cys Asp Ala His Gly 
1               5                   10                  15      


Ile Ser Gly Tyr Glu Ser Gly Val Arg Lys Leu Phe Glu Glu Arg Leu 
            20                  25                  30          


Arg Pro Leu Ser Glu Glu Leu Leu Arg Asp Arg Thr Gly Gly Val Val 
        35                  40                  45              


Gly Arg Lys Thr Gly Asp Pro Asn Gly Pro Lys Val Leu Ile Ala Gly 
    50                  55                  60                  


His Leu Asp Glu Ile Gly Phe Met Val Thr His Ile Thr Ser Glu Gly 
65                  70                  75                  80  


Phe Leu Lys Phe Gln Pro Ile Gly Gly Trp Trp Ser Gln Val Val Leu 
                85                  90                  95      


Ala Gln Arg Val Ile Val Gln Thr Arg Lys Gly Pro Leu Leu Gly Val 
            100                 105                 110         


Thr Gly Ser Lys Pro Pro His Ile Leu Pro Ala Asp Glu Arg Lys Lys 
        115                 120                 125             


Val Val Glu Leu Lys Asp Val Phe Val Asp Ile Gly Ala Thr Ser Lys 
    130                 135                 140                 


Glu His Ala Glu Glu Met Gly Val Arg Pro Gly Asp Ala Ile Val Pro 
145                 150                 155                 160 


Tyr Ser Pro Phe Thr Gln Leu Gly Asn Pro Lys Met Tyr Val Ser Lys 
                165                 170                 175     


Ala Leu Asp Asn Arg Leu Gly Cys Ala Thr Ala Leu Cys Val Leu Lys 
            180                 185                 190         


Glu Leu Gln Gly Gln Ala His Pro Asn Ile Val Phe Ala Gly Ala Thr 
        195                 200                 205             


Ala Gln Glu Glu Val Gly Leu Arg Gly Ala Lys Thr Leu Val His Leu 
    210                 215                 220                 


Val Asp Pro Asp Ile Ala Ile Ser Ile Asp Val Gly Val Ala Gly Asp 
225                 230                 235                 240 


Thr Pro Gly Ile Glu Ser Gly Glu Arg Gln His Leu Gly Asp Ala Gly 
                245                 250                 255     


Lys Gly Pro Leu Leu Met Ile Tyr Asp His Ser Met Ile Pro Asn Asn 
            260                 265                 270         


Arg Phe Arg Asp Phe Val Leu Asp Ile Ala Ala Thr Glu Asn Ile Pro 
        275                 280                 285             


Val Gln Leu Ser Ser Leu Ala Gly Gly Gly Thr Asp Ala Gly Ser Phe 
    290                 295                 300                 


His Leu His Gly Ile Gly Val Pro Ser Val Asn Ile Gly Phe Ala Thr 
305                 310                 315                 320 


Arg Tyr Ile His Ser His Asn Gly Val Val His Glu Asp Asp Tyr Leu 
                325                 330                 335     


Gln Ala Ile Arg Leu Val Thr Ala Met Val Lys Ala Leu Asp Lys Asp 
            340                 345                 350         


Met Val Thr Glu Ile Gln Ala Trp 
        355                 360 


<210>  250
<211>  360
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:236 and encoded by SEQ ID NO:245

<400>  250

Met His Pro His Val Glu Leu Leu Arg Asp Leu Cys Asp Ala His Gly 
1               5                   10                  15      


Ile Ser Gly Tyr Glu Ser Gly Val Arg Lys Leu Phe Glu Glu Arg Leu 
            20                  25                  30          


Arg Pro Leu Ser Glu Glu Leu Leu Arg Asp Arg Thr Gly Gly Val Val 
        35                  40                  45              


Gly Arg Lys Thr Gly Asp Pro Asn Gly Pro Lys Val Leu Ile Ala Gly 
    50                  55                  60                  


His Leu Asp Glu Ile Gly Phe Met Val Thr His Ile Thr Ser Glu Gly 
65                  70                  75                  80  


Phe Leu Lys Phe Gln Pro Ile Gly Gly Trp Trp Ser Gln Val Val Leu 
                85                  90                  95      


Ala Gln Arg Val Ile Val Gln Thr Arg Lys Gly Pro Leu Leu Gly Val 
            100                 105                 110         


Thr Gly Ser Lys Pro Pro His Ile Leu Pro Ala Asp Glu Arg Lys Lys 
        115                 120                 125             


Val Val Glu Leu Lys Asp Val Phe Val Asp Ile Gly Ala Thr Ser Lys 
    130                 135                 140                 


Glu His Ala Glu Glu Met Gly Val Arg Pro Gly Asp Ala Ile Val Pro 
145                 150                 155                 160 


Tyr Ser Pro Phe Thr Gln Leu Gly Asn Pro Lys Met Tyr Val Ser Lys 
                165                 170                 175     


Ala Leu Asp Asn Arg Leu Gly Cys Ala Thr Ala Leu Cys Val Leu Lys 
            180                 185                 190         


Glu Leu Gln Gly Gln Ala His Pro Asn Ile Val Phe Ala Gly Ala Thr 
        195                 200                 205             


Ala Gln Glu Glu Val Gly Leu Arg Gly Ala Lys Thr Leu Val His Leu 
    210                 215                 220                 


Val Asp Pro Asp Ile Ala Ile Ser Ile Asp Val Gly Val Ala Gly Asp 
225                 230                 235                 240 


Thr Pro Gly Ile Glu Ser Gly Glu Arg Gln His Leu Gly Asp Ala Gly 
                245                 250                 255     


Lys Gly Pro Leu Leu Met Ile Tyr Asp His Ser Met Ile Pro Asn Asn 
            260                 265                 270         


Arg Phe Arg Asp Phe Val Leu Asp Ile Ala Ala Thr Glu Asn Ile Pro 
        275                 280                 285             


Val Gln Leu Ser Ser Leu Ala Gly Gly Gly Thr Asp Ala Gly Ser Phe 
    290                 295                 300                 


His Leu His Gly Ile Gly Val Pro Ser Val Asn Ile Gly Phe Ala Thr 
305                 310                 315                 320 


Arg Tyr Ile His Ser His Asn Gly Val Val His Glu Asp Asp Tyr Leu 
                325                 330                 335     


Gln Ala Ile Arg Leu Val Thr Ala Met Val Lys Ala Leu Asp Lys Asp 
            340                 345                 350         


Met Val Thr Glu Ile Gln Ala Trp 
        355                 360 


<210>  251
<211>  360
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:236 and encoded by SEQ ID NO:246

<400>  251

Met His Pro His Val Glu Val Leu Lys Asp Leu Cys Asp Ala His Gly 
1               5                   10                  15      


Ile Ser Gly Tyr Glu Ser Gly Val Arg Lys Leu Phe Glu Glu Arg Leu 
            20                  25                  30          


Arg Pro Leu Ser Glu Glu Leu Leu Arg Asp Arg Thr Gly Gly Val Val 
        35                  40                  45              


Gly Arg Lys Thr Gly Asp Pro Asn Gly Pro Lys Val Leu Ile Ala Gly 
    50                  55                  60                  


His Leu Asp Glu Ile Gly Phe Met Val Thr His Ile Thr Ser Glu Gly 
65                  70                  75                  80  


Phe Leu Lys Phe Gln Pro Ile Gly Gly Trp Trp Ser Gln Val Val Leu 
                85                  90                  95      


Ala Gln Arg Val Ile Val Gln Thr Arg Lys Gly Pro Leu Leu Gly Val 
            100                 105                 110         


Thr Gly Ser Lys Pro Pro His Ile Leu Pro Ala Asp Glu Arg Lys Lys 
        115                 120                 125             


Val Val Glu Leu Lys Asp Val Phe Val Asp Ile Gly Ala Thr Ser Lys 
    130                 135                 140                 


Glu His Ala Glu Glu Met Gly Val Arg Pro Gly Asp Ala Ile Val Pro 
145                 150                 155                 160 


Tyr Ser Pro Phe Thr Gln Leu Gly Asn Pro Lys Met Tyr Val Ser Lys 
                165                 170                 175     


Ala Leu Asp Asn Arg Leu Gly Cys Ala Thr Ala Leu Cys Val Leu Lys 
            180                 185                 190         


Glu Leu Gln Gly Gln Ala His Pro Asn Ile Val Phe Ala Gly Ala Thr 
        195                 200                 205             


Ala Gln Glu Glu Val Gly Leu Arg Gly Ala Lys Thr Leu Val His Leu 
    210                 215                 220                 


Val Asp Pro Asp Ile Ala Ile Ser Ile Asp Val Gly Val Ala Gly Asp 
225                 230                 235                 240 


Thr Pro Gly Ile Glu Ser Gly Glu Arg Gln His Leu Gly Asp Ala Gly 
                245                 250                 255     


Lys Gly Pro Leu Leu Met Ile Tyr Asp His Ser Met Ile Pro Asn Asn 
            260                 265                 270         


Arg Phe Arg Asp Phe Val Leu Asp Ile Ala Ala Thr Glu Asn Ile Pro 
        275                 280                 285             


Val Gln Leu Ser Ser Leu Ala Gly Gly Gly Thr Asp Ala Gly Ser Phe 
    290                 295                 300                 


His Leu His Gly Ile Gly Val Pro Ser Val Asn Ile Gly Phe Ala Thr 
305                 310                 315                 320 


Arg Tyr Ile His Ser His Asn Gly Val Val His Glu Asp Asp Tyr Leu 
                325                 330                 335     


Gln Ala Ile Arg Leu Val Thr Ala Met Val Lys Ala Leu Asp Lys Asp 
            340                 345                 350         


Met Val Thr Glu Ile Gln Ala Trp 
        355                 360 


<210>  252
<211>  897
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  252
atgcctagcc tacaggctct ttccgttcga tcgatgttgc agcaaatgcg cgcatcgcag     60

aacctggcag aacaaagcct ggaagtgcag cgagctggcc tggatcaaat gggccgaacc    120

attcccaagc ccgaaaacgt gaaggtggag cgaacctcct tcggcggcgt gcccggcgaa    180

tggattgcga tggccgatga gcccacagcg cgcgtcatcc tgtatctgca cggcggagcg    240

tactacatgg ggagctgtga atcccaccga agcctcgcat ggcggctcgc tcaagcgtcg    300

ggatcgcgcg tcgccctcat cgagtaccga cttgcccccg agcacaagtt tccagccaca    360

gtcgaggacg ccgtgaaagc gtacgagtcc cttctcgcac aaggcatcgc accagaccga    420

atcgctatcg ccggagactc cgccggaggc ggcctgacga tggccacgct catctcgctg    480

cgcgacgcgg gcaaaccact cccagcgtgc gccgcactcc tctcgccttg gacggatttg    540

gcaggtacgg gtccgtccat ggaatcgcga gccgcacacg acccctggct tgatccagaa    600

gggatccgca aggcgccgct tttgtactgc agcgcggaac agctgacgca tccgctcgtg    660

tcgcctctct acgccgatct cgccggattg ccaccgatcc tcattcacgt gggccacgac    720

gagtgcctgc tcgacgactc cgtgagactg cacgaaaagc tccggcaggc cggtgtcgat    780

gcacgattgc atgtctggga ggacatgtgg cacgtgtttc acagcttccc aataccggag    840

gcggacgagg cgctgaaaga aatcggagat ttcatgaagg agaagattcc ggattaa       897


<210>  253
<211>  298
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  253

Met Pro Ser Leu Gln Ala Leu Ser Val Arg Ser Met Leu Gln Gln Met 
1               5                   10                  15      


Arg Ala Ser Gln Asn Leu Ala Glu Gln Ser Leu Glu Val Gln Arg Ala 
            20                  25                  30          


Gly Leu Asp Gln Met Gly Arg Thr Ile Pro Lys Pro Glu Asn Val Lys 
        35                  40                  45              


Val Glu Arg Thr Ser Phe Gly Gly Val Pro Gly Glu Trp Ile Ala Met 
    50                  55                  60                  


Ala Asp Glu Pro Thr Ala Arg Val Ile Leu Tyr Leu His Gly Gly Ala 
65                  70                  75                  80  


Tyr Tyr Met Gly Ser Cys Glu Ser His Arg Ser Leu Ala Trp Arg Leu 
                85                  90                  95      


Ala Gln Ala Ser Gly Ser Arg Val Ala Leu Ile Glu Tyr Arg Leu Ala 
            100                 105                 110         


Pro Glu His Lys Phe Pro Ala Thr Val Glu Asp Ala Val Lys Ala Tyr 
        115                 120                 125             


Glu Ser Leu Leu Ala Gln Gly Ile Ala Pro Asp Arg Ile Ala Ile Ala 
    130                 135                 140                 


Gly Asp Ser Ala Gly Gly Gly Leu Thr Met Ala Thr Leu Ile Ser Leu 
145                 150                 155                 160 


Arg Asp Ala Gly Lys Pro Leu Pro Ala Cys Ala Ala Leu Leu Ser Pro 
                165                 170                 175     


Trp Thr Asp Leu Ala Gly Thr Gly Pro Ser Met Glu Ser Arg Ala Ala 
            180                 185                 190         


His Asp Pro Trp Leu Asp Pro Glu Gly Ile Arg Lys Ala Pro Leu Leu 
        195                 200                 205             


Tyr Cys Ser Ala Glu Gln Leu Thr His Pro Leu Val Ser Pro Leu Tyr 
    210                 215                 220                 


Ala Asp Leu Ala Gly Leu Pro Pro Ile Leu Ile His Val Gly His Asp 
225                 230                 235                 240 


Glu Cys Leu Leu Asp Asp Ser Val Arg Leu His Glu Lys Leu Arg Gln 
                245                 250                 255     


Ala Gly Val Asp Ala Arg Leu His Val Trp Glu Asp Met Trp His Val 
            260                 265                 270         


Phe His Ser Phe Pro Ile Pro Glu Ala Asp Glu Ala Leu Lys Glu Ile 
        275                 280                 285             


Gly Asp Phe Met Lys Glu Lys Ile Pro Asp 
    290                 295             


<210>  254
<211>  266
<212>  PRT
<213>  Streptomyces coelicolor 

<400>  254

Met Val Ser Arg Arg Thr Val Leu Gly Gly Arg Pro Ala Leu Glu Leu 
1               5                   10                  15      


Ala Pro Asp Thr Ala Ser Gly Pro Gly Arg Leu Leu Tyr Leu His Gly 
            20                  25                  30          


Gly Gly Tyr Leu Ala Gly Ser Pro Asp Thr His Ala Gly Leu Ala Gly 
        35                  40                  45              


Glu Leu Ala Arg Arg Ala Gly Leu Arg Ala Val Ser Val Asp Tyr Arg 
    50                  55                  60                  


Leu Ala Pro Glu His Pro Phe Pro Ala Ala Val Asp Asp Gly Leu Ala 
65                  70                  75                  80  


Ala Tyr Arg Glu Leu Leu Ser Thr Gly Thr Asp Pro Gln Asp Leu Val 
                85                  90                  95      


Leu Ala Gly Asp Ser Ala Gly Gly Gly Leu Gly Ile Ala Thr Leu Leu 
            100                 105                 110         


Ala Ala Arg Glu Ala Gly Leu Pro Gln Pro Ala Ala Val Ala Leu Phe 
        115                 120                 125             


Ser Pro Trp Val Asp Leu Thr Leu Thr Gly Gly Ser Ile Arg Ser Lys 
    130                 135                 140                 


Glu Gly Ala Asp Pro Ile Phe Thr Glu Ala Asp Val Arg Ala Tyr Ala 
145                 150                 155                 160 


Asp Leu Tyr Val Gly Ala Gly Asp Arg Ala Ala Pro Leu Ala Ser Pro 
                165                 170                 175     


Val Phe Ala Asp Leu Ala Gly Leu Pro Pro Leu Leu Val Gln Ala Gly 
            180                 185                 190         


Ala Asn Glu Val Leu Leu Asp Asp Ala Val Arg Leu Ala Gly Arg Ala 
        195                 200                 205             


Gly Ala Asp Asp Val Glu Val Thr Leu Glu Val Gly Pro Gly Leu Pro 
    210                 215                 220                 


His Val Tyr Gln Leu His Tyr Gly Arg Leu Glu Glu Ala Asp Ala Ala 
225                 230                 235                 240 


Leu Asp Arg Ala Ala Arg Phe Leu Thr Ala His Leu Gly Ala Gly His 
                245                 250                 255     


Pro Asp Ala Gly Arg Leu Ala Pro Val Arg 
            260                 265     


<210>  255
<211>  316
<212>  PRT
<213>  Mesorhizobium loti 

<400>  255

Met Met Thr Ile His Pro Leu Ser Pro Glu Asp Ala Pro Ala Leu Ala 
1               5                   10                  15      


Ala Met Arg Gln Ala Ala Ser Ala His Lys Gly Glu Lys Leu Gly Pro 
            20                  25                  30          


Glu Ala Arg Pro Met Phe Asp Ala Met Phe Ala Ala Thr Pro Ala Ala 
        35                  40                  45              


Ala Asp Val Gln Val Glu Ala Ala Thr Ala Gly Gly Ile Ala Gly Phe 
    50                  55                  60                  


Trp Leu Arg Pro Val Ser Ala Arg Ser Gly Ala His Ile Leu Tyr Leu 
65                  70                  75                  80  


His Gly Gly Gly Tyr Val Leu Gly Ser Ala Gly Ala Leu Thr Asn Phe 
                85                  90                  95      


Ala Gly Gln Ile Ala Ser Arg Val Gly Ala Asp Thr Phe Val Pro Asp 
            100                 105                 110         


Tyr Arg Leu Ala Pro Glu His Pro Phe Pro Ala Ala Ile Asp Asp Ala 
        115                 120                 125             


Val Ala Ala Tyr Arg Gly Leu Val Ala Asp Gly Ala Glu Arg Ile Val 
    130                 135                 140                 


Val Val Gly Asp Ser Ala Gly Gly Gly Leu Thr Leu Ser Leu Leu Ser 
145                 150                 155                 160 


Ala Leu Ala Ala Asp Lys Thr Asn Gly Met Val Gln Pro Val Gly Ala 
                165                 170                 175     


Ala Val Met Ser Pro Trp Thr Asp Leu Ala Leu Thr Gly Asp Ser Leu 
            180                 185                 190         


Gly Thr Arg Ala Glu Ala Asp Pro Ile Phe Thr Gly Gly Val Leu Gln 
        195                 200                 205             


Gly Phe Ala Asp Met Tyr Leu Gln Gly Gln Asp Ala Lys Asn Pro Lys 
    210                 215                 220                 


Ala Ser Pro Leu Tyr Ala Arg Leu Asn Gly Leu Pro Pro Ile Arg Ile 
225                 230                 235                 240 


Asp Val Gly Asp Asp Glu Leu Leu Leu Ala Asp Ser Val Arg Tyr Ala 
                245                 250                 255     


Asp Arg Ala Arg Ala Ala Gly Val Glu Val Thr Leu Ser Val Trp Gln 
            260                 265                 270         


Gly Met Pro His Val Phe Gln Ser Ser Leu Gly His Phe Leu Ala Ala 
        275                 280                 285             


Glu Arg Ser Val Asp Ala Ile Val Asp Phe Leu Arg Gln Arg Leu Val 
    290                 295                 300                 


Gly Thr Ser Pro Ser Asn Ser Thr Ala Ser Glu Ala 
305                 310                 315     


<210>  256
<211>  316
<212>  PRT
<213>  Mesorhizobium loti

<400>  256

Met Ala Ser Ile Glu Ser Glu Ala Asn Arg Asn His Tyr Ala Ala Ile 
1               5                   10                  15      


Gly Ala Asn Ala Gly Lys Leu Ser Pro Gln Ala Phe Val Glu Phe Asn 
            20                  25                  30          


Asp Ser Ser Trp Thr Ala Leu Thr Gly Glu Pro Gly Gly Val Asp Tyr 
        35                  40                  45              


Ile Glu Val Asp Ala Gly Gly Val Pro Gly Leu Trp Val Val Pro Lys 
    50                  55                  60                  


Gly Ala Asp Glu Arg Arg Val Leu Phe Tyr Ala His Gly Gly Gly Phe 
65                  70                  75                  80  


Leu Gly Gly Ser Ile Tyr Thr His Arg Lys Leu Val Gly His Leu Ala 
                85                  90                  95      


Lys Ala Val Gly Cys Arg Ala Leu Leu Tyr Gly Tyr Pro Leu Ala Ser 
            100                 105                 110         


Gln Ala Lys Tyr Pro Ala Gln Leu Glu Ala Ala Met Ala Ala Trp Asp 
        115                 120                 125             


Trp Leu Ile Asp Gln Asp Phe Asp Thr Arg Arg Ile Ala Leu Ala Ala 
    130                 135                 140                 


Asp Ser Cys Gly Ala Val Leu Thr Tyr Gly Val Leu Gln Arg Leu Arg 
145                 150                 155                 160 


Ala Gln Glu Arg Pro Leu Pro Ala Ala Thr Leu Ile Ile Ser Gly Trp 
                165                 170                 175     


Phe Asp Met Ala Leu Thr Ala Ala Ser Tyr Glu Thr Asn Arg Glu Lys 
            180                 185                 190         


Asp Pro Phe Phe Ala Lys Gly Gly Val Asp Trp Leu Val Thr Ser Phe 
        195                 200                 205             


Ile Gly Asp Tyr Asp Arg Leu Asp Pro Glu Val Ser Pro Leu Tyr Ala 
    210                 215                 220                 


Asp Leu Ser Gly Phe Pro Pro Val Phe Leu Gln Ala Gly Ala Asp Glu 
225                 230                 235                 240 


Thr Leu Val Asp Glu Ser Arg Met Phe Ala Glu Arg Ala Arg Gln Ala 
                245                 250                 255     


Gly Val Glu Thr Arg Leu Asp Ile Phe Asp Asp Met Leu His Ser Phe 
            260                 265                 270         


Gln Met Met Ala Gly Arg Ala Pro Glu Ala Asp Asp Ala Ile Gly Arg 
        275                 280                 285             


Leu Ala Ala Trp Val Arg Pro Arg Leu Gly Leu Pro Asp Ala Gly Asp 
    290                 295                 300                 


Asn Ala Val Ser Asp Lys Val Ala Gly Arg Ala Ala 
305                 310                 315     


<210>  257
<211>  331
<212>  PRT
<213>  Synechocystis PCC6803

<400>  257

Met Val Tyr Ala Pro Arg Pro Leu Pro Ser Arg Ser Leu Pro Val Pro 
1               5                   10                  15      


Ala Ser Val Ser Pro Ala Leu Lys Lys Ala Ile Ala Gln Ser Leu Gln 
            20                  25                  30          


Gly Ala Met Glu Ala Ile Lys Asn Ile Pro Pro Leu Glu Asp Lys Pro 
        35                  40                  45              


Ala Trp Gln Thr Leu Ile Ala Ala Tyr Asp Gln Ala Ser Gln Val Leu 
    50                  55                  60                  


Trp Gln Lys Leu Arg Gln Gln Phe Pro Val Thr Leu Thr Lys Lys Ser 
65                  70                  75                  80  


Ile Ala Gly Val Asn Val Tyr Arg Val Thr Pro Pro Ile Ile Ser Pro 
                85                  90                  95      


Glu Asn Ser Gln Arg Ile Trp Val His Leu His Gly Gly Gly Tyr Ala 
            100                 105                 110         


Leu Ala Gly Gly Glu Leu Gly Thr Gly Glu Ala Val Leu Ala Ala His 
        115                 120                 125             


Tyr Gly Gln Val Gly Val Ile Ser Ile Asp Tyr Arg Gln Pro Pro Asn 
    130                 135                 140                 


Tyr Pro Phe Pro Ala Ala Leu Glu Asp Ala Leu Val Met Trp Gln Glu 
145                 150                 155                 160 


Leu Val Lys Thr His Asp Val Asn Arg Leu Ala Leu Phe Gly Thr Ser 
                165                 170                 175     


Ala Gly Gly Gly Leu Leu Leu Ala Leu Val Cys Gln Leu Arg Gln Leu 
            180                 185                 190         


Asn Leu Pro Leu Pro Ala Ala Ile Ala Pro Leu Ser Pro Trp Val Asp 
        195                 200                 205             


Leu Thr Lys Thr Gly Asp Thr His Phe Thr Asn Glu Tyr Val Asp Arg 
    210                 215                 220                 


Thr Ala Ile Ser Tyr Asp Gly Leu Ile Glu Gly Leu Ala Arg Leu Tyr 
225                 230                 235                 240 


Ala Gly Glu Leu Pro Leu Thr His Pro Leu Ile Ser Pro Ile Tyr Asn 
                245                 250                 255     


Asp Leu Ala Gly Leu Pro Pro Thr Leu Leu Ile Ser Gly Thr Arg Asp 
            260                 265                 270         


Leu Leu Leu Ser Asp Thr Ala Arg Leu Gln Arg Lys Leu Arg Gln Asn 
        275                 280                 285             


Lys Val Pro Val Asp Leu Gln Leu Phe Glu Gly Leu Ser His Ala Glu 
    290                 295                 300                 


Tyr Leu Tyr Glu Phe Asp Thr Pro Glu Ser Ala Glu Val Phe Arg Glu 
305                 310                 315                 320 


Leu Ser Gln Phe Phe Asn Arg His Leu Gln Lys 
                325                 330     


<210>  258
<211>  331
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  258

Met Ala Ala Lys Tyr Pro Leu Ser Pro Ala Met Trp Arg Phe Val Glu 
1               5                   10                  15      


His Ser Arg Ala Phe Ala Ser Asp Ser Pro Arg Leu Asp Ala Gln Arg 
            20                  25                  30          


Ala Ala Tyr Ala Arg Met Cys Gln Ala Phe Ala Pro Pro Arg Pro Ala 
        35                  40                  45              


Gly Leu Arg Val Leu Asp Ser Cys Leu Pro Ala Ala Pro Pro Val Arg 
    50                  55                  60                  


Val Arg Arg Tyr Arg Pro Asp Arg Pro Ala Pro Pro Gly Gly Trp Pro 
65                  70                  75                  80  


Ala Leu Leu Tyr Leu His Gly Gly Gly Trp Met Leu Gly Gly Leu Asp 
                85                  90                  95      


Ser His Asp Phe Ile Cys Ala Asp Leu Ala Ala Arg Leu Gly Leu Leu 
            100                 105                 110         


Val Leu Ala Val Asp Tyr Arg Leu Ala Pro Glu His Pro Phe Pro Ala 
        115                 120                 125             


Ala Leu Gln Asp Cys Leu Arg Ala Trp Gln Ala Leu Ser Leu Gly Glu 
    130                 135                 140                 


Leu Asp Glu Ala Leu Asp Gly Arg Arg Leu Leu Val Ala Gly Asp Ser 
145                 150                 155                 160 


Ala Gly Gly Asn Leu Ala Ala Ala Leu Cys Leu Ala Leu Arg Asp Gly 
                165                 170                 175     


Gly Ala Pro Ser Pro Ala Ala Gln Ile Leu Leu Tyr Pro Leu Leu Ser 
            180                 185                 190         


Ala Ala Pro Ser Pro Ser Arg Ile Asp Cys Ala Asp Ala Pro Leu Leu 
        195                 200                 205             


Gly Leu Gly Asp Val Gln Ala Cys Leu Asp Ala Tyr Leu Pro Leu Ala 
    210                 215                 220                 


Ala Leu His Arg Gln Pro Leu Ala Leu Pro Leu Glu Ala Ala Asp Phe 
225                 230                 235                 240 


Thr Gly Leu Pro Pro Ala Phe Val Ala Val Ala Glu Phe Asp Pro Leu 
                245                 250                 255     


Arg Asp Asp Gly Glu Arg Tyr Gly Ala Ala Leu Arg Ala Ala Gly Gly 
            260                 265                 270         


Glu Ala Gly Phe Tyr Pro Gly Ser Gly Leu Val His Gly Cys Leu Arg 
        275                 280                 285             


Gly His Gly Ile Asp Glu Val Glu Ala Leu His Glu Ala Leu Arg Arg 
    290                 295                 300                 


Ala Val Gln Gly Phe Leu Ala Glu Asp Ser Gly Glu Arg Gln Ala Gly 
305                 310                 315                 320 


Glu Glu Ser Thr Ala Glu His Gln Pro Gly Glu 
                325                 330     


<210>  259
<211>  897
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 252

<400>  259
atgcctagca tacaggctct ttccgttcga tcgatgttgc agcaaatgcg cgcatcgcag     60

aacctggcag aacaaagcct ggaagtgcag cgagctggcc tggatcaaat gggccgaacc    120

attcccaagc ccgaaaacgt gaaggtggag cgaacctcct tcggcggcgt gcccggcgaa    180

tggattgcga tggccgatga gcccacagcg cgcgtcatcc tgtatctgca cggcggagcg    240

tactacatgg ggagctgtga atcccaccga agcctcgcat ggcggctcgc tcaagcgtcg    300

ggatcgcgcg tcgccctcat cgagtaccga cttgcccccg agcacaagtt tccagccaca    360

gtcgaggacg ccgtgaaagc gtacgagtcc cttctcgcac aaggcatcgc accagaccga    420

atcgctatcg ccggagactc cgccggaggc ggcctgacga tggccacgct catctcgctg    480

cgcgacgcgg gcaaaccact cccagcgtgc gccgcactcc tctcgccttg gacggatttg    540

gcaggtacgg gtccgtccat ggaatcgcga gccgcacacg acccctggct tgatccagaa    600

gggatccgca aggcgccgct tttgtactgc agcgcggaac agctgacgca tccgctcgtg    660

tcgcctctct acgccgatct cgccggattg ccaccgatcc tcattcacgt gggccacgac    720

gagtgcctgc tcgacgactc cgtgagactg cacgaaaagc tccggcaggc cggtgtcgat    780

gcacgattgc atgtctggga ggacatgtgg cacgtgtttc acagcttccc aataccggag    840

gcggacgagg cgctgaaaga aatcggagat ttcatgaagg agaagattcc ggattaa       897


<210>  260
<211>  897
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 252

<400>  260
atgcctagcg tacaggctct ttccgttcga tcgatgttgc agcaaatgcg cgcatcgcag     60

aacctggcag aacaaagcct ggaagtgcag cgagctggcc tggatcaaat gggccgaacc    120

attcccaagc ccgaaaacgt gaaggtggag cgaacctcct tcggcggcgt gcccggcgaa    180

tggattgcga tggccgatga gcccacagcg cgcgtcatcc tgtatctgca cggcggagcg    240

tactacatgg ggagctgtga atcccaccga agcctcgcat ggcggctcgc tcaagcgtcg    300

ggatcgcgcg tcgccctcat cgagtaccga cttgcccccg agcacaagtt tccagccaca    360

gtcgaggacg ccgtgaaagc gtacgagtcc cttctcgcac aaggcatcgc accagaccga    420

atcgctatcg ccggagactc cgccggaggc ggcctgacga tggccacgct catctcgctg    480

cgcgacgcgg gcaaaccact cccagcgtgc gccgcactcc tctcgccttg gacggatttg    540

gcaggtacgg gtccgtccat ggaatcgcga gccgcacacg acccctggct tgatccagaa    600

gggatccgca aggcgccgct tttgtactgc agcgcggaac agctgacgca tccgctcgtg    660

tcgcctctct acgccgatct cgccggattg ccaccgatcc tcattcacgt gggccacgac    720

gagtgcctgc tcgacgactc cgtgagactg cacgaaaagc tccggcaggc cggtgtcgat    780

gcacgattgc atgtctggga ggacatgtgg cacgtgtttc acagcttccc aataccggag    840

gcggacgagg cgctgaaaga aatcggagat ttcatgaagg agaagattcc ggattaa       897


<210>  261
<211>  897
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 252

<400>  261
atgcctagcc tacaggctct ttccattcga tcgatgttgc agcaaatgcg cgcatcgcag     60

aacctggcag aacaaagcct ggaagtgcag cgagctggcc tggatcaaat gggccgaacc    120

attcccaagc ccgaaaacgt gaaggtggag cgaacctcct tcggcggcgt gcccggcgaa    180

tggattgcga tggccgatga gcccacagcg cgcgtcatcc tgtatctgca cggcggagcg    240

tactacatgg ggagctgtga atcccaccga agcctcgcat ggcggctcgc tcaagcgtcg    300

ggatcgcgcg tcgccctcat cgagtaccga cttgcccccg agcacaagtt tccagccaca    360

gtcgaggacg ccgtgaaagc gtacgagtcc cttctcgcac aaggcatcgc accagaccga    420

atcgctatcg ccggagactc cgccggaggc ggcctgacga tggccacgct catctcgctg    480

cgcgacgcgg gcaaaccact cccagcgtgc gccgcactcc tctcgccttg gacggatttg    540

gcaggtacgg gtccgtccat ggaatcgcga gccgcacacg acccctggct tgatccagaa    600

gggatccgca aggcgccgct tttgtactgc agcgcggaac agctgacgca tccgctcgtg    660

tcgcctctct acgccgatct cgccggattg ccaccgatcc tcattcacgt gggccacgac    720

gagtgcctgc tcgacgactc cgtgagactg cacgaaaagc tccggcaggc cggtgtcgat    780

gcacgattgc atgtctggga ggacatgtgg cacgtgtttc acagcttccc aataccggag    840

gcggacgagg cgctgaaaga aatcggagat ttcatgaagg agaagattcc ggattaa       897


<210>  262
<211>  897
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 252

<400>  262
atgcctagcc tacaggctct ttcccttcga tcgatgttgc agcaaatgcg cgcatcgcag     60

aacctggcag aacaaagcct ggaagtgcag cgagctggcc tggatcaaat gggccgaacc    120

attcccaagc ccgaaaacgt gaaggtggag cgaacctcct tcggcggcgt gcccggcgaa    180

tggattgcga tggccgatga gcccacagcg cgcgtcatcc tgtatctgca cggcggagcg    240

tactacatgg ggagctgtga atcccaccga agcctcgcat ggcggctcgc tcaagcgtcg    300

ggatcgcgcg tcgccctcat cgagtaccga cttgcccccg agcacaagtt tccagccaca    360

gtcgaggacg ccgtgaaagc gtacgagtcc cttctcgcac aaggcatcgc accagaccga    420

atcgctatcg ccggagactc cgccggaggc ggcctgacga tggccacgct catctcgctg    480

cgcgacgcgg gcaaaccact cccagcgtgc gccgcactcc tctcgccttg gacggatttg    540

gcaggtacgg gtccgtccat ggaatcgcga gccgcacacg acccctggct tgatccagaa    600

gggatccgca aggcgccgct tttgtactgc agcgcggaac agctgacgca tccgctcgtg    660

tcgcctctct acgccgatct cgccggattg ccaccgatcc tcattcacgt gggccacgac    720

gagtgcctgc tcgacgactc cgtgagactg cacgaaaagc tccggcaggc cggtgtcgat    780

gcacgattgc atgtctggga ggacatgtgg cacgtgtttc acagcttccc aataccggag    840

gcggacgagg cgctgaaaga aatcggagat ttcatgaagg agaagattcc ggattaa       897


<210>  263
<211>  897
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 252

<400>  263
atgcctagcc tacaggctct ttccgttaaa tcgatgttgc agcaaatgcg cgcatcgcag     60

aacctggcag aacaaagcct ggaagtgcag cgagctggcc tggatcaaat gggccgaacc    120

attcccaagc ccgaaaacgt gaaggtggag cgaacctcct tcggcggcgt gcccggcgaa    180

tggattgcga tggccgatga gcccacagcg cgcgtcatcc tgtatctgca cggcggagcg    240

tactacatgg ggagctgtga atcccaccga agcctcgcat ggcggctcgc tcaagcgtcg    300

ggatcgcgcg tcgccctcat cgagtaccga cttgcccccg agcacaagtt tccagccaca    360

gtcgaggacg ccgtgaaagc gtacgagtcc cttctcgcac aaggcatcgc accagaccga    420

atcgctatcg ccggagactc cgccggaggc ggcctgacga tggccacgct catctcgctg    480

cgcgacgcgg gcaaaccact cccagcgtgc gccgcactcc tctcgccttg gacggatttg    540

gcaggtacgg gtccgtccat ggaatcgcga gccgcacacg acccctggct tgatccagaa    600

gggatccgca aggcgccgct tttgtactgc agcgcggaac agctgacgca tccgctcgtg    660

tcgcctctct acgccgatct cgccggattg ccaccgatcc tcattcacgt gggccacgac    720

gagtgcctgc tcgacgactc cgtgagactg cacgaaaagc tccggcaggc cggtgtcgat    780

gcacgattgc atgtctggga ggacatgtgg cacgtgtttc acagcttccc aataccggag    840

gcggacgagg cgctgaaaga aatcggagat ttcatgaagg agaagattcc ggattaa       897


<210>  264
<211>  298
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:253 and encoded by SEQ ID NO:259

<400>  264

Met Pro Ser Ile Gln Ala Leu Ser Val Arg Ser Met Leu Gln Gln Met 
1               5                   10                  15      


Arg Ala Ser Gln Asn Leu Ala Glu Gln Ser Leu Glu Val Gln Arg Ala 
            20                  25                  30          


Gly Leu Asp Gln Met Gly Arg Thr Ile Pro Lys Pro Glu Asn Val Lys 
        35                  40                  45              


Val Glu Arg Thr Ser Phe Gly Gly Val Pro Gly Glu Trp Ile Ala Met 
    50                  55                  60                  


Ala Asp Glu Pro Thr Ala Arg Val Ile Leu Tyr Leu His Gly Gly Ala 
65                  70                  75                  80  


Tyr Tyr Met Gly Ser Cys Glu Ser His Arg Ser Leu Ala Trp Arg Leu 
                85                  90                  95      


Ala Gln Ala Ser Gly Ser Arg Val Ala Leu Ile Glu Tyr Arg Leu Ala 
            100                 105                 110         


Pro Glu His Lys Phe Pro Ala Thr Val Glu Asp Ala Val Lys Ala Tyr 
        115                 120                 125             


Glu Ser Leu Leu Ala Gln Gly Ile Ala Pro Asp Arg Ile Ala Ile Ala 
    130                 135                 140                 


Gly Asp Ser Ala Gly Gly Gly Leu Thr Met Ala Thr Leu Ile Ser Leu 
145                 150                 155                 160 


Arg Asp Ala Gly Lys Pro Leu Pro Ala Cys Ala Ala Leu Leu Ser Pro 
                165                 170                 175     


Trp Thr Asp Leu Ala Gly Thr Gly Pro Ser Met Glu Ser Arg Ala Ala 
            180                 185                 190         


His Asp Pro Trp Leu Asp Pro Glu Gly Ile Arg Lys Ala Pro Leu Leu 
        195                 200                 205             


Tyr Cys Ser Ala Glu Gln Leu Thr His Pro Leu Val Ser Pro Leu Tyr 
    210                 215                 220                 


Ala Asp Leu Ala Gly Leu Pro Pro Ile Leu Ile His Val Gly His Asp 
225                 230                 235                 240 


Glu Cys Leu Leu Asp Asp Ser Val Arg Leu His Glu Lys Leu Arg Gln 
                245                 250                 255     


Ala Gly Val Asp Ala Arg Leu His Val Trp Glu Asp Met Trp His Val 
            260                 265                 270         


Phe His Ser Phe Pro Ile Pro Glu Ala Asp Glu Ala Leu Lys Glu Ile 
        275                 280                 285             


Gly Asp Phe Met Lys Glu Lys Ile Pro Asp 
    290                 295             


<210>  265
<211>  298
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:253 and encoded by SEQ ID NO:260

<400>  265

Met Pro Ser Val Gln Ala Leu Ser Val Arg Ser Met Leu Gln Gln Met 
1               5                   10                  15      


Arg Ala Ser Gln Asn Leu Ala Glu Gln Ser Leu Glu Val Gln Arg Ala 
            20                  25                  30          


Gly Leu Asp Gln Met Gly Arg Thr Ile Pro Lys Pro Glu Asn Val Lys 
        35                  40                  45              


Val Glu Arg Thr Ser Phe Gly Gly Val Pro Gly Glu Trp Ile Ala Met 
    50                  55                  60                  


Ala Asp Glu Pro Thr Ala Arg Val Ile Leu Tyr Leu His Gly Gly Ala 
65                  70                  75                  80  


Tyr Tyr Met Gly Ser Cys Glu Ser His Arg Ser Leu Ala Trp Arg Leu 
                85                  90                  95      


Ala Gln Ala Ser Gly Ser Arg Val Ala Leu Ile Glu Tyr Arg Leu Ala 
            100                 105                 110         


Pro Glu His Lys Phe Pro Ala Thr Val Glu Asp Ala Val Lys Ala Tyr 
        115                 120                 125             


Glu Ser Leu Leu Ala Gln Gly Ile Ala Pro Asp Arg Ile Ala Ile Ala 
    130                 135                 140                 


Gly Asp Ser Ala Gly Gly Gly Leu Thr Met Ala Thr Leu Ile Ser Leu 
145                 150                 155                 160 


Arg Asp Ala Gly Lys Pro Leu Pro Ala Cys Ala Ala Leu Leu Ser Pro 
                165                 170                 175     


Trp Thr Asp Leu Ala Gly Thr Gly Pro Ser Met Glu Ser Arg Ala Ala 
            180                 185                 190         


His Asp Pro Trp Leu Asp Pro Glu Gly Ile Arg Lys Ala Pro Leu Leu 
        195                 200                 205             


Tyr Cys Ser Ala Glu Gln Leu Thr His Pro Leu Val Ser Pro Leu Tyr 
    210                 215                 220                 


Ala Asp Leu Ala Gly Leu Pro Pro Ile Leu Ile His Val Gly His Asp 
225                 230                 235                 240 


Glu Cys Leu Leu Asp Asp Ser Val Arg Leu His Glu Lys Leu Arg Gln 
                245                 250                 255     


Ala Gly Val Asp Ala Arg Leu His Val Trp Glu Asp Met Trp His Val 
            260                 265                 270         


Phe His Ser Phe Pro Ile Pro Glu Ala Asp Glu Ala Leu Lys Glu Ile 
        275                 280                 285             


Gly Asp Phe Met Lys Glu Lys Ile Pro Asp 
    290                 295             


<210>  266
<211>  298
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:253 and encoded by SEQ ID NO:261

<400>  266

Met Pro Ser Leu Gln Ala Leu Ser Ile Arg Ser Met Leu Gln Gln Met 
1               5                   10                  15      


Arg Ala Ser Gln Asn Leu Ala Glu Gln Ser Leu Glu Val Gln Arg Ala 
            20                  25                  30          


Gly Leu Asp Gln Met Gly Arg Thr Ile Pro Lys Pro Glu Asn Val Lys 
        35                  40                  45              


Val Glu Arg Thr Ser Phe Gly Gly Val Pro Gly Glu Trp Ile Ala Met 
    50                  55                  60                  


Ala Asp Glu Pro Thr Ala Arg Val Ile Leu Tyr Leu His Gly Gly Ala 
65                  70                  75                  80  


Tyr Tyr Met Gly Ser Cys Glu Ser His Arg Ser Leu Ala Trp Arg Leu 
                85                  90                  95      


Ala Gln Ala Ser Gly Ser Arg Val Ala Leu Ile Glu Tyr Arg Leu Ala 
            100                 105                 110         


Pro Glu His Lys Phe Pro Ala Thr Val Glu Asp Ala Val Lys Ala Tyr 
        115                 120                 125             


Glu Ser Leu Leu Ala Gln Gly Ile Ala Pro Asp Arg Ile Ala Ile Ala 
    130                 135                 140                 


Gly Asp Ser Ala Gly Gly Gly Leu Thr Met Ala Thr Leu Ile Ser Leu 
145                 150                 155                 160 


Arg Asp Ala Gly Lys Pro Leu Pro Ala Cys Ala Ala Leu Leu Ser Pro 
                165                 170                 175     


Trp Thr Asp Leu Ala Gly Thr Gly Pro Ser Met Glu Ser Arg Ala Ala 
            180                 185                 190         


His Asp Pro Trp Leu Asp Pro Glu Gly Ile Arg Lys Ala Pro Leu Leu 
        195                 200                 205             


Tyr Cys Ser Ala Glu Gln Leu Thr His Pro Leu Val Ser Pro Leu Tyr 
    210                 215                 220                 


Ala Asp Leu Ala Gly Leu Pro Pro Ile Leu Ile His Val Gly His Asp 
225                 230                 235                 240 


Glu Cys Leu Leu Asp Asp Ser Val Arg Leu His Glu Lys Leu Arg Gln 
                245                 250                 255     


Ala Gly Val Asp Ala Arg Leu His Val Trp Glu Asp Met Trp His Val 
            260                 265                 270         


Phe His Ser Phe Pro Ile Pro Glu Ala Asp Glu Ala Leu Lys Glu Ile 
        275                 280                 285             


Gly Asp Phe Met Lys Glu Lys Ile Pro Asp 
    290                 295             


<210>  267
<211>  298
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:253 and encoded by SEQ ID NO:262

<400>  267

Met Pro Ser Leu Gln Ala Leu Ser Leu Arg Ser Met Leu Gln Gln Met 
1               5                   10                  15      


Arg Ala Ser Gln Asn Leu Ala Glu Gln Ser Leu Glu Val Gln Arg Ala 
            20                  25                  30          


Gly Leu Asp Gln Met Gly Arg Thr Ile Pro Lys Pro Glu Asn Val Lys 
        35                  40                  45              


Val Glu Arg Thr Ser Phe Gly Gly Val Pro Gly Glu Trp Ile Ala Met 
    50                  55                  60                  


Ala Asp Glu Pro Thr Ala Arg Val Ile Leu Tyr Leu His Gly Gly Ala 
65                  70                  75                  80  


Tyr Tyr Met Gly Ser Cys Glu Ser His Arg Ser Leu Ala Trp Arg Leu 
                85                  90                  95      


Ala Gln Ala Ser Gly Ser Arg Val Ala Leu Ile Glu Tyr Arg Leu Ala 
            100                 105                 110         


Pro Glu His Lys Phe Pro Ala Thr Val Glu Asp Ala Val Lys Ala Tyr 
        115                 120                 125             


Glu Ser Leu Leu Ala Gln Gly Ile Ala Pro Asp Arg Ile Ala Ile Ala 
    130                 135                 140                 


Gly Asp Ser Ala Gly Gly Gly Leu Thr Met Ala Thr Leu Ile Ser Leu 
145                 150                 155                 160 


Arg Asp Ala Gly Lys Pro Leu Pro Ala Cys Ala Ala Leu Leu Ser Pro 
                165                 170                 175     


Trp Thr Asp Leu Ala Gly Thr Gly Pro Ser Met Glu Ser Arg Ala Ala 
            180                 185                 190         


His Asp Pro Trp Leu Asp Pro Glu Gly Ile Arg Lys Ala Pro Leu Leu 
        195                 200                 205             


Tyr Cys Ser Ala Glu Gln Leu Thr His Pro Leu Val Ser Pro Leu Tyr 
    210                 215                 220                 


Ala Asp Leu Ala Gly Leu Pro Pro Ile Leu Ile His Val Gly His Asp 
225                 230                 235                 240 


Glu Cys Leu Leu Asp Asp Ser Val Arg Leu His Glu Lys Leu Arg Gln 
                245                 250                 255     


Ala Gly Val Asp Ala Arg Leu His Val Trp Glu Asp Met Trp His Val 
            260                 265                 270         


Phe His Ser Phe Pro Ile Pro Glu Ala Asp Glu Ala Leu Lys Glu Ile 
        275                 280                 285             


Gly Asp Phe Met Lys Glu Lys Ile Pro Asp 
    290                 295             


<210>  268
<211>  298
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:253 and encoded by SEQ ID NO:263

<400>  268

Met Pro Ser Leu Gln Ala Leu Ser Val Lys Ser Met Leu Gln Gln Met 
1               5                   10                  15      


Arg Ala Ser Gln Asn Leu Ala Glu Gln Ser Leu Glu Val Gln Arg Ala 
            20                  25                  30          


Gly Leu Asp Gln Met Gly Arg Thr Ile Pro Lys Pro Glu Asn Val Lys 
        35                  40                  45              


Val Glu Arg Thr Ser Phe Gly Gly Val Pro Gly Glu Trp Ile Ala Met 
    50                  55                  60                  


Ala Asp Glu Pro Thr Ala Arg Val Ile Leu Tyr Leu His Gly Gly Ala 
65                  70                  75                  80  


Tyr Tyr Met Gly Ser Cys Glu Ser His Arg Ser Leu Ala Trp Arg Leu 
                85                  90                  95      


Ala Gln Ala Ser Gly Ser Arg Val Ala Leu Ile Glu Tyr Arg Leu Ala 
            100                 105                 110         


Pro Glu His Lys Phe Pro Ala Thr Val Glu Asp Ala Val Lys Ala Tyr 
        115                 120                 125             


Glu Ser Leu Leu Ala Gln Gly Ile Ala Pro Asp Arg Ile Ala Ile Ala 
    130                 135                 140                 


Gly Asp Ser Ala Gly Gly Gly Leu Thr Met Ala Thr Leu Ile Ser Leu 
145                 150                 155                 160 


Arg Asp Ala Gly Lys Pro Leu Pro Ala Cys Ala Ala Leu Leu Ser Pro 
                165                 170                 175     


Trp Thr Asp Leu Ala Gly Thr Gly Pro Ser Met Glu Ser Arg Ala Ala 
            180                 185                 190         


His Asp Pro Trp Leu Asp Pro Glu Gly Ile Arg Lys Ala Pro Leu Leu 
        195                 200                 205             


Tyr Cys Ser Ala Glu Gln Leu Thr His Pro Leu Val Ser Pro Leu Tyr 
    210                 215                 220                 


Ala Asp Leu Ala Gly Leu Pro Pro Ile Leu Ile His Val Gly His Asp 
225                 230                 235                 240 


Glu Cys Leu Leu Asp Asp Ser Val Arg Leu His Glu Lys Leu Arg Gln 
                245                 250                 255     


Ala Gly Val Asp Ala Arg Leu His Val Trp Glu Asp Met Trp His Val 
            260                 265                 270         


Phe His Ser Phe Pro Ile Pro Glu Ala Asp Glu Ala Leu Lys Glu Ile 
        275                 280                 285             


Gly Asp Phe Met Lys Glu Lys Ile Pro Asp 
    290                 295             


<210>  269
<211>  1017
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  269
atgacggatc aagcgccgtc tctgaaagaa gcgtacgctt cccgctttcg cgtgggcgct     60

gcggtcaacg cggcgaccgt tcacacgcac gcccatctcc tggcgcgcca cttcagcagt    120

gtgacgccgg agaacgagat gaagtgggag cgcatccacc ctgccgaaga cacgtattct    180

ttttctgctg ctgaccaaat cgttttattc gcccgcgatc acggcatgtt cgtgcgcggc    240

cacacgctcg tgtggcacaa ccagacgcct tcttgggtgt tcctggactc tctcggccaa    300

cccgcgcccg cgaagctcgt cgaggcaagg ctcgagcagc acatcgccga ggtcgtgggt    360

cactaccgcg gcgccgcctt gtgctgggac gtggtgaacg aggccgtgat cgaccaaggg    420

gacggctggc tgcgcccgag cccatggcgg caggcgctgg gggacgacta catcgagatg    480

gcgtttcgct tggcgcatca ggcggatccc ggcgcgctac tcttctacaa cgactacaac    540

gagacgaagc ccgataagcg ggaccgcatc ctgcggctgc tcgagcacct gttggaccgc    600

ggagtgcccg tgcatggcgt ggggctgcag atgcacgtct ccctggacga tccgcccatc    660

gaggagatgg aggaggccat cgagcggtac cgggcgctcg gccttcggct gcacgtcacg    720

gagctcgatg tgagcgtgta cccgtgggtg cacgagccgg accgcccaca ggcgcctgcg    780

cggccgtacg acgatgagct ggccgagcgg ctcgcggcgc gctacgaggc cctgtttgcg    840

ctctatttgc ggcatcagga cgccatcgac aacgtgacgc tctggggcgt cgcggacgac    900

tcgacgtggc gagacgactt ccccgtcaag ggcaggaagg actggccgct tctcttcgac    960

gtccatcacc gcccgaagga ggcgttctgg cgggtggtgc gcctcgccca aaactga      1017


<210>  270
<211>  338
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  270

Met Thr Asp Gln Ala Pro Ser Leu Lys Glu Ala Tyr Ala Ser Arg Phe 
1               5                   10                  15      


Arg Val Gly Ala Ala Val Asn Ala Ala Thr Val His Thr His Ala His 
            20                  25                  30          


Leu Leu Ala Arg His Phe Ser Ser Val Thr Pro Glu Asn Glu Met Lys 
        35                  40                  45              


Trp Glu Arg Ile His Pro Ala Glu Asp Thr Tyr Ser Phe Ser Ala Ala 
    50                  55                  60                  


Asp Gln Ile Val Leu Phe Ala Arg Asp His Gly Met Phe Val Arg Gly 
65                  70                  75                  80  


His Thr Leu Val Trp His Asn Gln Thr Pro Ser Trp Val Phe Leu Asp 
                85                  90                  95      


Ser Leu Gly Gln Pro Ala Pro Ala Lys Leu Val Glu Ala Arg Leu Glu 
            100                 105                 110         


Gln His Ile Ala Glu Val Val Gly His Tyr Arg Gly Ala Ala Leu Cys 
        115                 120                 125             


Trp Asp Val Val Asn Glu Ala Val Ile Asp Gln Gly Asp Gly Trp Leu 
    130                 135                 140                 


Arg Pro Ser Pro Trp Arg Gln Ala Leu Gly Asp Asp Tyr Ile Glu Met 
145                 150                 155                 160 


Ala Phe Arg Leu Ala His Gln Ala Asp Pro Gly Ala Leu Leu Phe Tyr 
                165                 170                 175     


Asn Asp Tyr Asn Glu Thr Lys Pro Asp Lys Arg Asp Arg Ile Leu Arg 
            180                 185                 190         


Leu Leu Glu His Leu Leu Asp Arg Gly Val Pro Val His Gly Val Gly 
        195                 200                 205             


Leu Gln Met His Val Ser Leu Asp Asp Pro Pro Ile Glu Glu Met Glu 
    210                 215                 220                 


Glu Ala Ile Glu Arg Tyr Arg Ala Leu Gly Leu Arg Leu His Val Thr 
225                 230                 235                 240 


Glu Leu Asp Val Ser Val Tyr Pro Trp Val His Glu Pro Asp Arg Pro 
                245                 250                 255     


Gln Ala Pro Ala Arg Pro Tyr Asp Asp Glu Leu Ala Glu Arg Leu Ala 
            260                 265                 270         


Ala Arg Tyr Glu Ala Leu Phe Ala Leu Tyr Leu Arg His Gln Asp Ala 
        275                 280                 285             


Ile Asp Asn Val Thr Leu Trp Gly Val Ala Asp Asp Ser Thr Trp Arg 
    290                 295                 300                 


Asp Asp Phe Pro Val Lys Gly Arg Lys Asp Trp Pro Leu Leu Phe Asp 
305                 310                 315                 320 


Val His His Arg Pro Lys Glu Ala Phe Trp Arg Val Val Arg Leu Ala 
                325                 330                 335     


Gln Asn 
        


<210>  271
<211>  339
<212>  PRT
<213>  Geobacillus stearothermophilus

<400>  271

Met Val Gly Gly Gly Gly Met Lys Met Asn Ser Ser Leu Pro Ser Leu 
1               5                   10                  15      


Arg Asp Val Phe Ala Asn Asp Phe Arg Ile Gly Ala Ala Val Asn Pro 
            20                  25                  30          


Val Thr Ile Glu Met Gln Lys Gln Leu Leu Ile Asp His Val Asn Ser 
        35                  40                  45              


Ile Thr Ala Glu Asn His Met Lys Phe Glu His Leu Gln Pro Glu Glu 
    50                  55                  60                  


Gly Lys Phe Thr Phe Gln Glu Ala Asp Arg Ile Val Asp Phe Ala Cys 
65                  70                  75                  80  


Ser His Arg Met Ala Val Arg Gly His Thr Leu Val Trp His Asn Gln 
                85                  90                  95      


Thr Pro Asp Trp Val Phe Gln Asp Gly Gln Gly His Phe Val Ser Arg 
            100                 105                 110         


Asp Val Leu Leu Glu Arg Met Lys Cys His Ile Ser Thr Val Val Arg 
        115                 120                 125             


Arg Tyr Lys Gly Lys Ile Tyr Cys Trp Asp Val Ile Asn Glu Ala Val 
    130                 135                 140                 


Ala Asp Glu Gly Asn Glu Leu Leu Arg Pro Ser Lys Trp Arg Gln Ile 
145                 150                 155                 160 


Ile Gly Asp Asp Phe Met Glu Gln Ala Phe Leu Tyr Ala Tyr Glu Ala 
                165                 170                 175     


Asp Pro Asp Ala Leu Leu Phe Tyr Asn Asp Tyr Asn Glu Cys Phe Pro 
            180                 185                 190         


Glu Lys Arg Glu Lys Ile Phe Ala Leu Val Lys Ser Leu Arg Asp Lys 
        195                 200                 205             


Gly Ile Pro Ile His Gly Ile Gly Met Gln Ala His Trp Ser Leu Thr 
    210                 215                 220                 


Arg Pro Ser Leu Asp Glu Ile Arg Ala Ala Ile Glu Arg Tyr Ala Ser 
225                 230                 235                 240 


Leu Gly Val Val Leu His Ile Thr Glu Leu Asp Val Ser Met Phe Glu 
                245                 250                 255     


Phe His Asp Arg Arg Thr Asp Leu Ala Ala Pro Thr Ser Glu Met Ile 
            260                 265                 270         


Glu Arg Gln Ala Glu Arg Tyr Gly Gln Ile Phe Ala Leu Phe Lys Glu 
        275                 280                 285             


Tyr Arg Asp Val Ile Gln Ser Val Thr Phe Trp Gly Ile Ala Asp Asp 
    290                 295                 300                 


His Thr Trp Leu Asp Asn Phe Pro Val His Gly Arg Lys Asn Trp Pro 
305                 310                 315                 320 


Leu Leu Phe Asp Glu Gln His Lys Pro Lys Pro Ala Phe Trp Arg Ala 
                325                 330                 335     


Val Ser Val 
            


<210>  272
<211>  333
<212>  PRT
<213>  Geobacillus thermodenitrificans

<400>  272

Met Ser Val Ser Gln Ser Leu Pro Ser Leu Arg Glu Val Phe Ala Asn 
1               5                   10                  15      


Asp Phe Arg Ile Gly Ala Ala Val Asn Pro Val Thr Ile Glu Ser Gln 
            20                  25                  30          


Lys Gln Leu Leu Ile Ser His Val Asn Ser Leu Thr Ala Glu Asn His 
        35                  40                  45              


Met Lys Phe Glu His Leu Gln Pro Glu Glu Gly Arg Phe Thr Phe Asp 
    50                  55                  60                  


Ile Ala Asp Arg Ile Val Asp Phe Ala Arg Ser His His Met Ala Val 
65                  70                  75                  80  


Arg Gly His Thr Leu Val Trp His Asn Gln Thr Pro Asp Trp Val Phe 
                85                  90                  95      


Gln Asp Gly Gln Gly His Phe Ile Ser Arg Asp Val Leu Leu Glu Arg 
            100                 105                 110         


Met Lys Ser His Ile Ser Ala Val Val Arg Arg Tyr Lys Gly Lys Val 
        115                 120                 125             


Tyr Cys Trp Asp Val Val Asn Glu Ala Val Ala Asp Glu Gly Ser Glu 
    130                 135                 140                 


Trp Leu Arg Ser Ser Lys Trp Arg Gln Ile Ile Gly Asp Asp Phe Ile 
145                 150                 155                 160 


Glu Gln Ala Phe Leu Cys Ala His Glu Ala Asp Pro Asp Ala Leu Leu 
                165                 170                 175     


Phe Tyr Asn Asp Tyr Asn Glu Cys Phe Pro Lys Lys Arg Glu Lys Ile 
            180                 185                 190         


Tyr Thr Leu Val Lys Ser Leu Arg Asp Lys Gly Ile Pro Ile His Gly 
        195                 200                 205             


Ile Gly Met Gln Ala His Trp Ser Leu Thr Arg Pro Ser Leu Asp Glu 
    210                 215                 220                 


Ile Arg Ala Ala Ile Glu Arg Tyr Ala Ser Leu Asp Val Val Leu His 
225                 230                 235                 240 


Ile Thr Glu Leu Asp Val Ser Met Phe Glu Phe His Asp His Arg Lys 
                245                 250                 255     


Asp Leu Ala Ala Pro Thr Asn Glu Met Ile Glu Arg Gln Ala Glu Arg 
            260                 265                 270         


Tyr Glu Gln Ile Phe Thr Leu Phe Lys Glu Tyr Arg Asp Val Ile Glu 
        275                 280                 285             


Ser Val Thr Phe Trp Gly Met Ala Asp Asp Tyr Thr Trp Leu Asp His 
    290                 295                 300                 


Phe Pro Val Gln Gly Arg Lys Asn Trp Pro Phe Leu Phe Asp Glu Gln 
305                 310                 315                 320 


His Glu Pro Lys Ser Ala Phe Trp Arg Val Ala Ser Ile 
                325                 330             


<210>  273
<211>  331
<212>  PRT
<213>  Geobacillus stearothermophilus

<400>  273

Met Asn Ser Ser Leu Pro Ser Leu Arg Asp Val Phe Ala Asn Asp Phe 
1               5                   10                  15      


Arg Ile Gly Ala Ala Val Asn Pro Val Thr Ile Glu Met Gln Lys Gln 
            20                  25                  30          


Leu Leu Ile Asp His Val Asn Ser Ile Thr Ala Glu Asn His Met Lys 
        35                  40                  45              


Phe Glu His Leu Gln Pro Glu Glu Gly Lys Phe Thr Phe Gln Glu Ala 
    50                  55                  60                  


Asp Arg Ile Val Asp Phe Ala Cys Ser His Arg Met Ala Val Arg Gly 
65                  70                  75                  80  


His Thr Leu Val Trp His Asn Gln Thr Pro Asp Trp Val Phe Gln Asp 
                85                  90                  95      


Gly Gln Gly His Phe Val Ser Arg Asp Val Leu Leu Glu Arg Met Lys 
            100                 105                 110         


Cys His Ile Ser Thr Val Val Arg Arg Tyr Lys Gly Lys Ile Tyr Cys 
        115                 120                 125             


Trp Asp Val Ile Asn Glu Ala Val Ala Asp Glu Gly Asp Glu Leu Leu 
    130                 135                 140                 


Arg Pro Ser Lys Trp Arg Gln Ile Ile Gly Asp Asp Phe Met Glu Gln 
145                 150                 155                 160 


Ala Phe Leu Tyr Ala Tyr Glu Ala Asp Pro Asp Ala Leu Leu Phe Tyr 
                165                 170                 175     


Asn Asp Tyr Asn Glu Cys Phe Pro Glu Lys Arg Glu Lys Ile Phe Ala 
            180                 185                 190         


Leu Val Lys Ser Leu Arg Asp Lys Gly Ile Pro Ile His Gly Ile Gly 
        195                 200                 205             


Met Gln Ala His Trp Ser Leu Thr Arg Pro Ser Leu Asp Glu Ile Arg 
    210                 215                 220                 


Ala Ala Ile Glu Arg Tyr Ala Ser Leu Gly Val Val Leu His Ile Thr 
225                 230                 235                 240 


Glu Leu Asp Val Ser Met Phe Glu Phe His Asp Arg Arg Thr Asp Leu 
                245                 250                 255     


Ala Ala Pro Thr Ser Glu Met Ile Glu Arg Gln Ala Glu Arg Tyr Gly 
            260                 265                 270         


Gln Ile Phe Ala Leu Phe Lys Glu Tyr Arg Asp Val Ile Gln Ser Val 
        275                 280                 285             


Thr Phe Trp Gly Ile Ala Asp Asp His Thr Trp Leu Asp Asn Phe Pro 
    290                 295                 300                 


Val His Gly Arg Lys Asn Trp Pro Leu Leu Phe Asp Glu Gln His Lys 
305                 310                 315                 320 


Pro Lys Pro Ala Phe Trp Arg Ala Val Ser Val 
                325                 330     


<210>  274
<211>  333
<212>  PRT
<213>  Aeromonas punctata

<400>  274

Met Pro Thr Glu Ile Pro Ser Leu His Ala Ala Tyr Ala Asn Thr Phe 
1               5                   10                  15      


Lys Ile Gly Ala Ala Val His Thr Arg Met Leu Gln Ser Glu Gly Glu 
            20                  25                  30          


Phe Ile Ala Lys His Phe Asn Ser Ile Thr Ala Glu Asn Gln Met Lys 
        35                  40                  45              


Phe Glu Glu Ile His Pro Glu Glu Asp Arg Tyr Ser Phe Glu Ala Ala 
    50                  55                  60                  


Asp Gln Ile Val Asp Phe Ala Val Ala Gln Gly Ile Gly Val Arg Gly 
65                  70                  75                  80  


His Thr Leu Val Trp His Asn Gln Thr Ser Lys Trp Val Phe Glu Asp 
                85                  90                  95      


Thr Ser Gly Ala Pro Ala Ser Arg Glu Leu Leu Leu Ser Arg Leu Lys 
            100                 105                 110         


Gln His Ile Asp Thr Val Val Gly Arg Tyr Lys Gly Gln Ile Tyr Ala 
        115                 120                 125             


Trp Asp Val Val Asn Glu Ala Val Glu Asp Lys Thr Asp Leu Phe Met 
    130                 135                 140                 


Arg Asp Thr Lys Trp Leu Glu Leu Val Gly Glu Asp Tyr Leu Leu Gln 
145                 150                 155                 160 


Ala Phe Ser Met Ala His Glu Ala Asp Pro Asn Ala Leu Leu Phe Tyr 
                165                 170                 175     


Asn Asp Tyr Asn Glu Thr Asp Pro Val Lys Arg Glu Lys Ile Tyr Asn 
            180                 185                 190         


Leu Val Arg Ser Leu Leu Asp Lys Gly Ala Pro Val His Gly Ile Gly 
        195                 200                 205             


Leu Gln Gly His Trp Asn Ile His Gly Pro Ser Ile Glu Glu Ile Arg 
    210                 215                 220                 


Met Ala Ile Glu Arg Tyr Ala Ser Leu Asp Val Gln Leu His Val Thr 
225                 230                 235                 240 


Glu Leu Asp Met Ser Val Phe Arg His Glu Asp Arg Arg Thr Asp Leu 
                245                 250                 255     


Thr Ala Pro Thr Ser Glu Met Ala Glu Leu Gln Glu Leu Arg Tyr Glu 
            260                 265                 270         


Glu Ile Phe Asn Leu Phe Arg Glu Tyr Lys Ser Ser Ile Thr Ser Val 
        275                 280                 285             


Thr Phe Trp Gly Val Ala Asp Asn Tyr Thr Trp Leu Asp His Phe Pro 
    290                 295                 300                 


Val Arg Gly Arg Lys Asn Trp Pro Phe Val Phe Asp Gln Gln Leu Gln 
305                 310                 315                 320 


Pro Lys Val Ser Phe Trp Arg Ile Ile Asn Ser Met Ser 
                325                 330             


<210>  275
<211>  332
<212>  PRT
<213>  Bacillus BP-23

<400>  275

Met Ser Thr Glu Ile Pro Ser Leu Ser Ala Ser Tyr Ala Asn Ser Phe 
1               5                   10                  15      


Lys Ile Gly Ala Ala Val His Thr Arg Met Leu Gln Thr Glu Gly Glu 
            20                  25                  30          


Phe Ile Ala Lys His Tyr Asn Ser Val Thr Ala Glu Asn Gln Met Lys 
        35                  40                  45              


Phe Glu Glu Val His Pro Arg Glu His Glu Tyr Thr Phe Glu Ala Ala 
    50                  55                  60                  


Asp Glu Ile Val Asp Phe Ala Val Ala Arg Gly Ile Gly Val Arg Gly 
65                  70                  75                  80  


His Thr Leu Val Trp His Asn Gln Thr Pro Ala Trp Met Phe Glu Asp 
                85                  90                  95      


Ala Ser Gly Gly Thr Ala Ser Arg Glu Met Met Leu Ser Arg Leu Lys 
            100                 105                 110         


Gln His Ile Asp Thr Val Val Gly Arg Tyr Lys Asp Gln Ile Tyr Ala 
        115                 120                 125             


Trp Asp Val Val Asn Glu Ala Ile Glu Asp Lys Thr Asp Leu Ile Met 
    130                 135                 140                 


Arg Asp Thr Lys Trp Leu Arg Leu Leu Gly Glu Asp Tyr Leu Val Gln 
145                 150                 155                 160 


Ala Phe Asn Met Ala His Glu Ala Asp Pro Asn Ala Leu Leu Phe Tyr 
                165                 170                 175     


Asn Asp Tyr Asn Glu Thr Asp Pro Val Lys Arg Glu Lys Ile Tyr Asn 
            180                 185                 190         


Leu Val Arg Ser Leu Leu Asp Gln Gly Ala Pro Val His Gly Ile Gly 
        195                 200                 205             


Met Gln Gly His Trp Asn Ile His Gly Pro Ser Met Asp Glu Ile Arg 
    210                 215                 220                 


Gln Ala Ile Glu Arg Tyr Ala Ser Leu Asp Val Gln Leu His Val Thr 
225                 230                 235                 240 


Glu Leu Asp Leu Ser Val Phe Arg His Glu Asp Gln Arg Thr Asp Leu 
                245                 250                 255     


Thr Glu Pro Thr Ala Glu Met Ala Glu Leu Gln Gln Lys Arg Tyr Glu 
            260                 265                 270         


Asp Ile Phe Gly Leu Phe Arg Glu Tyr Arg Ser Asn Ile Thr Ser Val 
        275                 280                 285             


Thr Phe Trp Gly Val Ala Asp Asn Tyr Thr Trp Leu Asp Asn Phe Pro 
    290                 295                 300                 


Val Arg Gly Arg Lys Asn Trp Pro Phe Val Phe Asp Thr Glu Leu Gln 
305                 310                 315                 320 


Pro Lys Asp Ser Phe Trp Arg Ile Ile Gly Gln Asp 
                325                 330         


<210>  276
<211>  1017
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 269

<400>  276
atgacggaac aagcgccgtc tctgaaagaa gcgtacgctt cccgctttcg cgtgggcgct     60

gcggtcaacg cggcgaccgt tcacacgcac gcccatctcc tggcgcgcca cttcagcagt    120

gtgacgccgg agaacgagat gaagtgggag cgcatccacc ctgccgaaga cacgtattct    180

ttttctgctg ctgaccaaat cgttttattc gcccgcgatc acggcatgtt cgtgcgcggc    240

cacacgctcg tgtggcacaa ccagacgcct tcttgggtgt tcctggactc tctcggccaa    300

cccgcgcccg cgaagctcgt cgaggcaagg ctcgagcagc acatcgccga ggtcgtgggt    360

cactaccgcg gcgccgcctt gtgctgggac gtggtgaacg aggccgtgat cgaccaaggg    420

gacggctggc tgcgcccgag cccatggcgg caggcgctgg gggacgacta catcgagatg    480

gcgtttcgct tggcgcatca ggcggatccc ggcgcgctac tcttctacaa cgactacaac    540

gagacgaagc ccgataagcg ggaccgcatc ctgcggctgc tcgagcacct gttggaccgc    600

ggagtgcccg tgcatggcgt ggggctgcag atgcacgtct ccctggacga tccgcccatc    660

gaggagatgg aggaggccat cgagcggtac cgggcgctcg gccttcggct gcacgtcacg    720

gagctcgatg tgagcgtgta cccgtgggtg cacgagccgg accgcccaca ggcgcctgcg    780

cggccgtacg acgatgagct ggccgagcgg ctcgcggcgc gctacgaggc cctgtttgcg    840

ctctatttgc ggcatcagga cgccatcgac aacgtgacgc tctggggcgt cgcggacgac    900

tcgacgtggc gagacgactt ccccgtcaag ggcaggaagg actggccgct tctcttcgac    960

gtccatcacc gcccgaagga ggcgttctgg cgggtggtgc gcctcgccca aaactga      1017


<210>  277
<211>  1017
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 269

<400>  277
atgacggata acgcgccgtc tctgaaagaa gcgtacgctt cccgctttcg cgtgggcgct     60

gcggtcaacg cggcgaccgt tcacacgcac gcccatctcc tggcgcgcca cttcagcagt    120

gtgacgccgg agaacgagat gaagtgggag cgcatccacc ctgccgaaga cacgtattct    180

ttttctgctg ctgaccaaat cgttttattc gcccgcgatc acggcatgtt cgtgcgcggc    240

cacacgctcg tgtggcacaa ccagacgcct tcttgggtgt tcctggactc tctcggccaa    300

cccgcgcccg cgaagctcgt cgaggcaagg ctcgagcagc acatcgccga ggtcgtgggt    360

cactaccgcg gcgccgcctt gtgctgggac gtggtgaacg aggccgtgat cgaccaaggg    420

gacggctggc tgcgcccgag cccatggcgg caggcgctgg gggacgacta catcgagatg    480

gcgtttcgct tggcgcatca ggcggatccc ggcgcgctac tcttctacaa cgactacaac    540

gagacgaagc ccgataagcg ggaccgcatc ctgcggctgc tcgagcacct gttggaccgc    600

ggagtgcccg tgcatggcgt ggggctgcag atgcacgtct ccctggacga tccgcccatc    660

gaggagatgg aggaggccat cgagcggtac cgggcgctcg gccttcggct gcacgtcacg    720

gagctcgatg tgagcgtgta cccgtgggtg cacgagccgg accgcccaca ggcgcctgcg    780

cggccgtacg acgatgagct ggccgagcgg ctcgcggcgc gctacgaggc cctgtttgcg    840

ctctatttgc ggcatcagga cgccatcgac aacgtgacgc tctggggcgt cgcggacgac    900

tcgacgtggc gagacgactt ccccgtcaag ggcaggaagg actggccgct tctcttcgac    960

gtccatcacc gcccgaagga ggcgttctgg cgggtggtgc gcctcgccca aaactga      1017


<210>  278
<211>  1017
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 269

<400>  278
atgacggatc aagcgccgtc tctgagagaa gcgtacgctt cccgctttcg cgtgggcgct     60

gcggtcaacg cggcgaccgt tcacacgcac gcccatctcc tggcgcgcca cttcagcagt    120

gtgacgccgg agaacgagat gaagtgggag cgcatccacc ctgccgaaga cacgtattct    180

ttttctgctg ctgaccaaat cgttttattc gcccgcgatc acggcatgtt cgtgcgcggc    240

cacacgctcg tgtggcacaa ccagacgcct tcttgggtgt tcctggactc tctcggccaa    300

cccgcgcccg cgaagctcgt cgaggcaagg ctcgagcagc acatcgccga ggtcgtgggt    360

cactaccgcg gcgccgcctt gtgctgggac gtggtgaacg aggccgtgat cgaccaaggg    420

gacggctggc tgcgcccgag cccatggcgg caggcgctgg gggacgacta catcgagatg    480

gcgtttcgct tggcgcatca ggcggatccc ggcgcgctac tcttctacaa cgactacaac    540

gagacgaagc ccgataagcg ggaccgcatc ctgcggctgc tcgagcacct gttggaccgc    600

ggagtgcccg tgcatggcgt ggggctgcag atgcacgtct ccctggacga tccgcccatc    660

gaggagatgg aggaggccat cgagcggtac cgggcgctcg gccttcggct gcacgtcacg    720

gagctcgatg tgagcgtgta cccgtgggtg cacgagccgg accgcccaca ggcgcctgcg    780

cggccgtacg acgatgagct ggccgagcgg ctcgcggcgc gctacgaggc cctgtttgcg    840

ctctatttgc ggcatcagga cgccatcgac aacgtgacgc tctggggcgt cgcggacgac    900

tcgacgtggc gagacgactt ccccgtcaag ggcaggaagg actggccgct tctcttcgac    960

gtccatcacc gcccgaagga ggcgttctgg cgggtggtgc gcctcgccca aaactga      1017


<210>  279
<211>  1017
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 269

<400>  279
atgacggatc aagcgccgtc tctgaaagac gcgtacgctt cccgctttcg cgtgggcgct     60

gcggtcaacg cggcgaccgt tcacacgcac gcccatctcc tggcgcgcca cttcagcagt    120

gtgacgccgg agaacgagat gaagtgggag cgcatccacc ctgccgaaga cacgtattct    180

ttttctgctg ctgaccaaat cgttttattc gcccgcgatc acggcatgtt cgtgcgcggc    240

cacacgctcg tgtggcacaa ccagacgcct tcttgggtgt tcctggactc tctcggccaa    300

cccgcgcccg cgaagctcgt cgaggcaagg ctcgagcagc acatcgccga ggtcgtgggt    360

cactaccgcg gcgccgcctt gtgctgggac gtggtgaacg aggccgtgat cgaccaaggg    420

gacggctggc tgcgcccgag cccatggcgg caggcgctgg gggacgacta catcgagatg    480

gcgtttcgct tggcgcatca ggcggatccc ggcgcgctac tcttctacaa cgactacaac    540

gagacgaagc ccgataagcg ggaccgcatc ctgcggctgc tcgagcacct gttggaccgc    600

ggagtgcccg tgcatggcgt ggggctgcag atgcacgtct ccctggacga tccgcccatc    660

gaggagatgg aggaggccat cgagcggtac cgggcgctcg gccttcggct gcacgtcacg    720

gagctcgatg tgagcgtgta cccgtgggtg cacgagccgg accgcccaca ggcgcctgcg    780

cggccgtacg acgatgagct ggccgagcgg ctcgcggcgc gctacgaggc cctgtttgcg    840

ctctatttgc ggcatcagga cgccatcgac aacgtgacgc tctggggcgt cgcggacgac    900

tcgacgtggc gagacgactt ccccgtcaag ggcaggaagg actggccgct tctcttcgac    960

gtccatcacc gcccgaagga ggcgttctgg cgggtggtgc gcctcgccca aaactga      1017


<210>  280
<211>  1017
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 269

<400>  280
atgacggatc aagcgccgtc tctgaaagaa gcgtacgctt ccaaatttcg cgtgggcgct     60

gcggtcaacg cggcgaccgt tcacacgcac gcccatctcc tggcgcgcca cttcagcagt    120

gtgacgccgg agaacgagat gaagtgggag cgcatccacc ctgccgaaga cacgtattct    180

ttttctgctg ctgaccaaat cgttttattc gcccgcgatc acggcatgtt cgtgcgcggc    240

cacacgctcg tgtggcacaa ccagacgcct tcttgggtgt tcctggactc tctcggccaa    300

cccgcgcccg cgaagctcgt cgaggcaagg ctcgagcagc acatcgccga ggtcgtgggt    360

cactaccgcg gcgccgcctt gtgctgggac gtggtgaacg aggccgtgat cgaccaaggg    420

gacggctggc tgcgcccgag cccatggcgg caggcgctgg gggacgacta catcgagatg    480

gcgtttcgct tggcgcatca ggcggatccc ggcgcgctac tcttctacaa cgactacaac    540

gagacgaagc ccgataagcg ggaccgcatc ctgcggctgc tcgagcacct gttggaccgc    600

ggagtgcccg tgcatggcgt ggggctgcag atgcacgtct ccctggacga tccgcccatc    660

gaggagatgg aggaggccat cgagcggtac cgggcgctcg gccttcggct gcacgtcacg    720

gagctcgatg tgagcgtgta cccgtgggtg cacgagccgg accgcccaca ggcgcctgcg    780

cggccgtacg acgatgagct ggccgagcgg ctcgcggcgc gctacgaggc cctgtttgcg    840

ctctatttgc ggcatcagga cgccatcgac aacgtgacgc tctggggcgt cgcggacgac    900

tcgacgtggc gagacgactt ccccgtcaag ggcaggaagg actggccgct tctcttcgac    960

gtccatcacc gcccgaagga ggcgttctgg cgggtggtgc gcctcgccca aaactga      1017


<210>  281
<211>  338
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:270 and encoded by SEQ ID NO:276

<400>  281

Met Thr Glu Gln Ala Pro Ser Leu Lys Glu Ala Tyr Ala Ser Arg Phe 
1               5                   10                  15      


Arg Val Gly Ala Ala Val Asn Ala Ala Thr Val His Thr His Ala His 
            20                  25                  30          


Leu Leu Ala Arg His Phe Ser Ser Val Thr Pro Glu Asn Glu Met Lys 
        35                  40                  45              


Trp Glu Arg Ile His Pro Ala Glu Asp Thr Tyr Ser Phe Ser Ala Ala 
    50                  55                  60                  


Asp Gln Ile Val Leu Phe Ala Arg Asp His Gly Met Phe Val Arg Gly 
65                  70                  75                  80  


His Thr Leu Val Trp His Asn Gln Thr Pro Ser Trp Val Phe Leu Asp 
                85                  90                  95      


Ser Leu Gly Gln Pro Ala Pro Ala Lys Leu Val Glu Ala Arg Leu Glu 
            100                 105                 110         


Gln His Ile Ala Glu Val Val Gly His Tyr Arg Gly Ala Ala Leu Cys 
        115                 120                 125             


Trp Asp Val Val Asn Glu Ala Val Ile Asp Gln Gly Asp Gly Trp Leu 
    130                 135                 140                 


Arg Pro Ser Pro Trp Arg Gln Ala Leu Gly Asp Asp Tyr Ile Glu Met 
145                 150                 155                 160 


Ala Phe Arg Leu Ala His Gln Ala Asp Pro Gly Ala Leu Leu Phe Tyr 
                165                 170                 175     


Asn Asp Tyr Asn Glu Thr Lys Pro Asp Lys Arg Asp Arg Ile Leu Arg 
            180                 185                 190         


Leu Leu Glu His Leu Leu Asp Arg Gly Val Pro Val His Gly Val Gly 
        195                 200                 205             


Leu Gln Met His Val Ser Leu Asp Asp Pro Pro Ile Glu Glu Met Glu 
    210                 215                 220                 


Glu Ala Ile Glu Arg Tyr Arg Ala Leu Gly Leu Arg Leu His Val Thr 
225                 230                 235                 240 


Glu Leu Asp Val Ser Val Tyr Pro Trp Val His Glu Pro Asp Arg Pro 
                245                 250                 255     


Gln Ala Pro Ala Arg Pro Tyr Asp Asp Glu Leu Ala Glu Arg Leu Ala 
            260                 265                 270         


Ala Arg Tyr Glu Ala Leu Phe Ala Leu Tyr Leu Arg His Gln Asp Ala 
        275                 280                 285             


Ile Asp Asn Val Thr Leu Trp Gly Val Ala Asp Asp Ser Thr Trp Arg 
    290                 295                 300                 


Asp Asp Phe Pro Val Lys Gly Arg Lys Asp Trp Pro Leu Leu Phe Asp 
305                 310                 315                 320 


Val His His Arg Pro Lys Glu Ala Phe Trp Arg Val Val Arg Leu Ala 
                325                 330                 335     


Gln Asn 
        


<210>  282
<211>  338
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:270 and encoded by SEQ ID NO:277

<400>  282

Met Thr Asp Asn Ala Pro Ser Leu Lys Glu Ala Tyr Ala Ser Arg Phe 
1               5                   10                  15      


Arg Val Gly Ala Ala Val Asn Ala Ala Thr Val His Thr His Ala His 
            20                  25                  30          


Leu Leu Ala Arg His Phe Ser Ser Val Thr Pro Glu Asn Glu Met Lys 
        35                  40                  45              


Trp Glu Arg Ile His Pro Ala Glu Asp Thr Tyr Ser Phe Ser Ala Ala 
    50                  55                  60                  


Asp Gln Ile Val Leu Phe Ala Arg Asp His Gly Met Phe Val Arg Gly 
65                  70                  75                  80  


His Thr Leu Val Trp His Asn Gln Thr Pro Ser Trp Val Phe Leu Asp 
                85                  90                  95      


Ser Leu Gly Gln Pro Ala Pro Ala Lys Leu Val Glu Ala Arg Leu Glu 
            100                 105                 110         


Gln His Ile Ala Glu Val Val Gly His Tyr Arg Gly Ala Ala Leu Cys 
        115                 120                 125             


Trp Asp Val Val Asn Glu Ala Val Ile Asp Gln Gly Asp Gly Trp Leu 
    130                 135                 140                 


Arg Pro Ser Pro Trp Arg Gln Ala Leu Gly Asp Asp Tyr Ile Glu Met 
145                 150                 155                 160 


Ala Phe Arg Leu Ala His Gln Ala Asp Pro Gly Ala Leu Leu Phe Tyr 
                165                 170                 175     


Asn Asp Tyr Asn Glu Thr Lys Pro Asp Lys Arg Asp Arg Ile Leu Arg 
            180                 185                 190         


Leu Leu Glu His Leu Leu Asp Arg Gly Val Pro Val His Gly Val Gly 
        195                 200                 205             


Leu Gln Met His Val Ser Leu Asp Asp Pro Pro Ile Glu Glu Met Glu 
    210                 215                 220                 


Glu Ala Ile Glu Arg Tyr Arg Ala Leu Gly Leu Arg Leu His Val Thr 
225                 230                 235                 240 


Glu Leu Asp Val Ser Val Tyr Pro Trp Val His Glu Pro Asp Arg Pro 
                245                 250                 255     


Gln Ala Pro Ala Arg Pro Tyr Asp Asp Glu Leu Ala Glu Arg Leu Ala 
            260                 265                 270         


Ala Arg Tyr Glu Ala Leu Phe Ala Leu Tyr Leu Arg His Gln Asp Ala 
        275                 280                 285             


Ile Asp Asn Val Thr Leu Trp Gly Val Ala Asp Asp Ser Thr Trp Arg 
    290                 295                 300                 


Asp Asp Phe Pro Val Lys Gly Arg Lys Asp Trp Pro Leu Leu Phe Asp 
305                 310                 315                 320 


Val His His Arg Pro Lys Glu Ala Phe Trp Arg Val Val Arg Leu Ala 
                325                 330                 335     


Gln Asn 
        


<210>  283
<211>  338
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:270 and encoded by SEQ ID NO:278

<400>  283

Met Thr Asp Gln Ala Pro Ser Leu Arg Glu Ala Tyr Ala Ser Arg Phe 
1               5                   10                  15      


Arg Val Gly Ala Ala Val Asn Ala Ala Thr Val His Thr His Ala His 
            20                  25                  30          


Leu Leu Ala Arg His Phe Ser Ser Val Thr Pro Glu Asn Glu Met Lys 
        35                  40                  45              


Trp Glu Arg Ile His Pro Ala Glu Asp Thr Tyr Ser Phe Ser Ala Ala 
    50                  55                  60                  


Asp Gln Ile Val Leu Phe Ala Arg Asp His Gly Met Phe Val Arg Gly 
65                  70                  75                  80  


His Thr Leu Val Trp His Asn Gln Thr Pro Ser Trp Val Phe Leu Asp 
                85                  90                  95      


Ser Leu Gly Gln Pro Ala Pro Ala Lys Leu Val Glu Ala Arg Leu Glu 
            100                 105                 110         


Gln His Ile Ala Glu Val Val Gly His Tyr Arg Gly Ala Ala Leu Cys 
        115                 120                 125             


Trp Asp Val Val Asn Glu Ala Val Ile Asp Gln Gly Asp Gly Trp Leu 
    130                 135                 140                 


Arg Pro Ser Pro Trp Arg Gln Ala Leu Gly Asp Asp Tyr Ile Glu Met 
145                 150                 155                 160 


Ala Phe Arg Leu Ala His Gln Ala Asp Pro Gly Ala Leu Leu Phe Tyr 
                165                 170                 175     


Asn Asp Tyr Asn Glu Thr Lys Pro Asp Lys Arg Asp Arg Ile Leu Arg 
            180                 185                 190         


Leu Leu Glu His Leu Leu Asp Arg Gly Val Pro Val His Gly Val Gly 
        195                 200                 205             


Leu Gln Met His Val Ser Leu Asp Asp Pro Pro Ile Glu Glu Met Glu 
    210                 215                 220                 


Glu Ala Ile Glu Arg Tyr Arg Ala Leu Gly Leu Arg Leu His Val Thr 
225                 230                 235                 240 


Glu Leu Asp Val Ser Val Tyr Pro Trp Val His Glu Pro Asp Arg Pro 
                245                 250                 255     


Gln Ala Pro Ala Arg Pro Tyr Asp Asp Glu Leu Ala Glu Arg Leu Ala 
            260                 265                 270         


Ala Arg Tyr Glu Ala Leu Phe Ala Leu Tyr Leu Arg His Gln Asp Ala 
        275                 280                 285             


Ile Asp Asn Val Thr Leu Trp Gly Val Ala Asp Asp Ser Thr Trp Arg 
    290                 295                 300                 


Asp Asp Phe Pro Val Lys Gly Arg Lys Asp Trp Pro Leu Leu Phe Asp 
305                 310                 315                 320 


Val His His Arg Pro Lys Glu Ala Phe Trp Arg Val Val Arg Leu Ala 
                325                 330                 335     


Gln Asn 
        


<210>  284
<211>  338
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:270 and encoded by SEQ ID NO:279

<400>  284

Met Thr Asp Gln Ala Pro Ser Leu Lys Asp Ala Tyr Ala Ser Arg Phe 
1               5                   10                  15      


Arg Val Gly Ala Ala Val Asn Ala Ala Thr Val His Thr His Ala His 
            20                  25                  30          


Leu Leu Ala Arg His Phe Ser Ser Val Thr Pro Glu Asn Glu Met Lys 
        35                  40                  45              


Trp Glu Arg Ile His Pro Ala Glu Asp Thr Tyr Ser Phe Ser Ala Ala 
    50                  55                  60                  


Asp Gln Ile Val Leu Phe Ala Arg Asp His Gly Met Phe Val Arg Gly 
65                  70                  75                  80  


His Thr Leu Val Trp His Asn Gln Thr Pro Ser Trp Val Phe Leu Asp 
                85                  90                  95      


Ser Leu Gly Gln Pro Ala Pro Ala Lys Leu Val Glu Ala Arg Leu Glu 
            100                 105                 110         


Gln His Ile Ala Glu Val Val Gly His Tyr Arg Gly Ala Ala Leu Cys 
        115                 120                 125             


Trp Asp Val Val Asn Glu Ala Val Ile Asp Gln Gly Asp Gly Trp Leu 
    130                 135                 140                 


Arg Pro Ser Pro Trp Arg Gln Ala Leu Gly Asp Asp Tyr Ile Glu Met 
145                 150                 155                 160 


Ala Phe Arg Leu Ala His Gln Ala Asp Pro Gly Ala Leu Leu Phe Tyr 
                165                 170                 175     


Asn Asp Tyr Asn Glu Thr Lys Pro Asp Lys Arg Asp Arg Ile Leu Arg 
            180                 185                 190         


Leu Leu Glu His Leu Leu Asp Arg Gly Val Pro Val His Gly Val Gly 
        195                 200                 205             


Leu Gln Met His Val Ser Leu Asp Asp Pro Pro Ile Glu Glu Met Glu 
    210                 215                 220                 


Glu Ala Ile Glu Arg Tyr Arg Ala Leu Gly Leu Arg Leu His Val Thr 
225                 230                 235                 240 


Glu Leu Asp Val Ser Val Tyr Pro Trp Val His Glu Pro Asp Arg Pro 
                245                 250                 255     


Gln Ala Pro Ala Arg Pro Tyr Asp Asp Glu Leu Ala Glu Arg Leu Ala 
            260                 265                 270         


Ala Arg Tyr Glu Ala Leu Phe Ala Leu Tyr Leu Arg His Gln Asp Ala 
        275                 280                 285             


Ile Asp Asn Val Thr Leu Trp Gly Val Ala Asp Asp Ser Thr Trp Arg 
    290                 295                 300                 


Asp Asp Phe Pro Val Lys Gly Arg Lys Asp Trp Pro Leu Leu Phe Asp 
305                 310                 315                 320 


Val His His Arg Pro Lys Glu Ala Phe Trp Arg Val Val Arg Leu Ala 
                325                 330                 335     


Gln Asn 
        


<210>  285
<211>  338
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:270 and encoded by SEQ ID NO:280

<400>  285

Met Thr Asp Gln Ala Pro Ser Leu Lys Glu Ala Tyr Ala Ser Lys Phe 
1               5                   10                  15      


Arg Val Gly Ala Ala Val Asn Ala Ala Thr Val His Thr His Ala His 
            20                  25                  30          


Leu Leu Ala Arg His Phe Ser Ser Val Thr Pro Glu Asn Glu Met Lys 
        35                  40                  45              


Trp Glu Arg Ile His Pro Ala Glu Asp Thr Tyr Ser Phe Ser Ala Ala 
    50                  55                  60                  


Asp Gln Ile Val Leu Phe Ala Arg Asp His Gly Met Phe Val Arg Gly 
65                  70                  75                  80  


His Thr Leu Val Trp His Asn Gln Thr Pro Ser Trp Val Phe Leu Asp 
                85                  90                  95      


Ser Leu Gly Gln Pro Ala Pro Ala Lys Leu Val Glu Ala Arg Leu Glu 
            100                 105                 110         


Gln His Ile Ala Glu Val Val Gly His Tyr Arg Gly Ala Ala Leu Cys 
        115                 120                 125             


Trp Asp Val Val Asn Glu Ala Val Ile Asp Gln Gly Asp Gly Trp Leu 
    130                 135                 140                 


Arg Pro Ser Pro Trp Arg Gln Ala Leu Gly Asp Asp Tyr Ile Glu Met 
145                 150                 155                 160 


Ala Phe Arg Leu Ala His Gln Ala Asp Pro Gly Ala Leu Leu Phe Tyr 
                165                 170                 175     


Asn Asp Tyr Asn Glu Thr Lys Pro Asp Lys Arg Asp Arg Ile Leu Arg 
            180                 185                 190         


Leu Leu Glu His Leu Leu Asp Arg Gly Val Pro Val His Gly Val Gly 
        195                 200                 205             


Leu Gln Met His Val Ser Leu Asp Asp Pro Pro Ile Glu Glu Met Glu 
    210                 215                 220                 


Glu Ala Ile Glu Arg Tyr Arg Ala Leu Gly Leu Arg Leu His Val Thr 
225                 230                 235                 240 


Glu Leu Asp Val Ser Val Tyr Pro Trp Val His Glu Pro Asp Arg Pro 
                245                 250                 255     


Gln Ala Pro Ala Arg Pro Tyr Asp Asp Glu Leu Ala Glu Arg Leu Ala 
            260                 265                 270         


Ala Arg Tyr Glu Ala Leu Phe Ala Leu Tyr Leu Arg His Gln Asp Ala 
        275                 280                 285             


Ile Asp Asn Val Thr Leu Trp Gly Val Ala Asp Asp Ser Thr Trp Arg 
    290                 295                 300                 


Asp Asp Phe Pro Val Lys Gly Arg Lys Asp Trp Pro Leu Leu Phe Asp 
305                 310                 315                 320 


Val His His Arg Pro Lys Glu Ala Phe Trp Arg Val Val Arg Leu Ala 
                325                 330                 335     


Gln Asn 
        


<210>  286
<211>  837
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  286
gtgcggaaac tgtcccattc ggggaaatcc atggcgattc cgccaaggga gcgtgttggg     60

atgcagagag ccgtcgagct cgaggtggac ggtctcgtcc ttcgcggcat ggagcacgtg    120

ccggacgagg cagcgaaccg ccccgtgcct gccgccattc tgtttcacgg cttcacgggc    180

acacacatcg aacctcatca gctgtttgtc aagttgagcc gcgcgctcga ggccgagggg    240

gtggcggcgt ttcgcttcga tttcgccgga agcggggact ccgacggcga gtttcaggac    300

atgacagctt cttcggagat tcgagacgcg aaggcgattt tggactgggt gcggcgagat    360

ccccgcattg acccagaccg cgtgagcctc atcggcctca gcatgggagg ttacgtggcg    420

tccatcgtgg ccggggacga gccggacaag gtggacaggc tcgtgctgct tgcgccggcg    480

ggcaacatgg ccgacatcgc ggagaagcag gcggaggcgc tcggcgcggc ggccgacgcc    540

gacgtggtgg atctcggcgg gaacctcgtg ggccgcgggc tgtacgagga tctgaagcag    600

attgacgcat tcgagcgggc gaagccgttt cgcggcaagg tgctcatcat ccacgggatg    660

gaggatcagg ccgtcccgta cgaggtgtcg ctgaagtacc agaacgaggt ctacggcgaa    720

cgcgcgcggc ttcatctgat tgaagaggcg gatcacacgt tcaacaatcg gcactgggag    780

tccgaggtca ttcgggaaac cgtgcggttt ttgacggacg tggaccggtc gcaatga       837


<210>  287
<211>  278
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  287

Met Arg Lys Leu Ser His Ser Gly Lys Ser Met Ala Ile Pro Pro Arg 
1               5                   10                  15      


Glu Arg Val Gly Met Gln Arg Ala Val Glu Leu Glu Val Asp Gly Leu 
            20                  25                  30          


Val Leu Arg Gly Met Glu His Val Pro Asp Glu Ala Ala Asn Arg Pro 
        35                  40                  45              


Val Pro Ala Ala Ile Leu Phe His Gly Phe Thr Gly Thr His Ile Glu 
    50                  55                  60                  


Pro His Gln Leu Phe Val Lys Leu Ser Arg Ala Leu Glu Ala Glu Gly 
65                  70                  75                  80  


Val Ala Ala Phe Arg Phe Asp Phe Ala Gly Ser Gly Asp Ser Asp Gly 
                85                  90                  95      


Glu Phe Gln Asp Met Thr Ala Ser Ser Glu Ile Arg Asp Ala Lys Ala 
            100                 105                 110         


Ile Leu Asp Trp Val Arg Arg Asp Pro Arg Ile Asp Pro Asp Arg Val 
        115                 120                 125             


Ser Leu Ile Gly Leu Ser Met Gly Gly Tyr Val Ala Ser Ile Val Ala 
    130                 135                 140                 


Gly Asp Glu Pro Asp Lys Val Asp Arg Leu Val Leu Leu Ala Pro Ala 
145                 150                 155                 160 


Gly Asn Met Ala Asp Ile Ala Glu Lys Gln Ala Glu Ala Leu Gly Ala 
                165                 170                 175     


Ala Ala Asp Ala Asp Val Val Asp Leu Gly Gly Asn Leu Val Gly Arg 
            180                 185                 190         


Gly Leu Tyr Glu Asp Leu Lys Gln Ile Asp Ala Phe Glu Arg Ala Lys 
        195                 200                 205             


Pro Phe Arg Gly Lys Val Leu Ile Ile His Gly Met Glu Asp Gln Ala 
    210                 215                 220                 


Val Pro Tyr Glu Val Ser Leu Lys Tyr Gln Asn Glu Val Tyr Gly Glu 
225                 230                 235                 240 


Arg Ala Arg Leu His Leu Ile Glu Glu Ala Asp His Thr Phe Asn Asn 
                245                 250                 255     


Arg His Trp Glu Ser Glu Val Ile Arg Glu Thr Val Arg Phe Leu Thr 
            260                 265                 270         


Asp Val Asp Arg Ser Gln 
        275             


<210>  288
<211>  259
<212>  PRT
<213>  Thermoanaerobacter ethanolicus 

<400>  288

Met Gln Lys Ala Val Glu Ile Thr Tyr Asn Gly Lys Thr Leu Arg Gly 
1               5                   10                  15      


Met Met His Leu Pro Asp Asp Val Lys Gly Lys Val Pro Met Val Ile 
            20                  25                  30          


Met Phe His Gly Phe Thr Gly Asn Lys Val Glu Ser His Phe Ile Phe 
        35                  40                  45              


Val Lys Met Ser Arg Ala Leu Glu Lys Val Gly Ile Gly Ser Val Arg 
    50                  55                  60                  


Phe Asp Phe Tyr Gly Ser Gly Glu Ser Asp Gly Asp Phe Ser Glu Met 
65                  70                  75                  80  


Thr Phe Ser Ser Glu Leu Glu Asp Ala Arg Gln Ile Leu Lys Phe Val 
                85                  90                  95      


Lys Glu Gln Pro Thr Thr Asp Pro Glu Arg Ile Gly Leu Leu Gly Leu 
            100                 105                 110         


Ser Met Gly Gly Ala Ile Ala Gly Ile Val Ala Arg Glu Tyr Lys Asp 
        115                 120                 125             


Glu Ile Lys Ala Leu Val Leu Trp Ala Pro Ala Phe Asn Met Pro Glu 
    130                 135                 140                 


Leu Ile Met His Glu Ser Val Lys Gln Tyr Gly Ala Ile Met Glu Gln 
145                 150                 155                 160 


Leu Gly Phe Val Asp Ile Gly Gly His Lys Leu Ser Lys Asp Phe Val 
                165                 170                 175     


Glu Asp Ile Ser Lys Leu Asn Ile Phe Glu Leu Ser Lys Gly Tyr Asp 
            180                 185                 190         


Lys Lys Val Leu Ile Val His Gly Thr Asn Asp Glu Ala Val Glu Tyr 
        195                 200                 205             


Lys Val Ser Asp Arg Ile Leu Lys Glu Val Tyr Gly Asp Asn Ala Thr 
    210                 215                 220                 


Arg Val Thr Ile Glu Asn Ala Asp His Thr Phe Lys Ser Leu Glu Trp 
225                 230                 235                 240 


Glu Lys Lys Ala Ile Glu Glu Ser Val Glu Phe Phe Lys Lys Glu Leu 
                245                 250                 255     


Leu Lys Gly 
            


<210>  289
<211>  261
<212>  PRT
<213>  Thermoanaerobacter ethanolicus

<400>  289

Met Gln Lys His Val Glu Phe Thr Tyr Asn Gly Lys Thr Leu Arg Gly 
1               5                   10                  15      


Met Met His Leu Pro Asp Gly Ile His Gly Lys Val Pro Met Val Ala 
            20                  25                  30          


Ile Phe His Gly Phe Thr Gly Asn Lys Met Glu Pro His Phe Ile Phe 
        35                  40                  45              


Val Lys Leu Ser Arg Gln Leu Glu Lys Val Gly Ile Gly Ser Val Arg 
    50                  55                  60                  


Phe Asp Phe Tyr Gly Ser Gly Glu Ser Asp Gly Asp Phe Ser Glu Met 
65                  70                  75                  80  


Thr Phe Ser Gly Glu Leu Glu Asp Ala Arg Gln Ile Ile Lys Phe Ile 
                85                  90                  95      


Lys Asn Glu Pro Met Ala Asp Val Glu Asn Ile Gly Ile Leu Gly Leu 
            100                 105                 110         


Ser Met Gly Gly Ala Val Ala Gly Val Ile Ala Ser Glu Leu Lys Glu 
        115                 120                 125             


Glu Ile Lys Ala Leu Ala Leu Trp Ala Pro Ala Phe Asn Met Pro Glu 
    130                 135                 140                 


Leu Ile Leu Glu Gln Ser Lys Ser Ala Asp Glu Lys Met Leu Gly Met 
145                 150                 155                 160 


Leu Glu Arg Glu Gly Ile Ile Asp Ile Gly Gly Leu Ala Leu Ser Lys 
                165                 170                 175     


Glu Phe Ile Asp Asp Leu Ile Lys Leu Asn Ile Phe Glu Phe Ser Lys 
            180                 185                 190         


Gly Tyr Asp Lys Pro Val Leu Ile Val His Gly Thr Glu Asp Ala Ala 
        195                 200                 205             


Val Lys Tyr Glu Val Ser Asp Lys Ile Leu Glu Glu Val Tyr Arg Gly 
    210                 215                 220                 


Asn Ala Lys Arg Ile Thr Ile Glu Gly Ala Asp His Thr Phe Asn Lys 
225                 230                 235                 240 


Leu Glu Trp Glu Lys Lys Ala Ile Glu Glu Ser Ile Asn Phe Phe Lys 
                245                 250                 255     


Glu Asn Leu Lys Gly 
            260     


<210>  290
<211>  265
<212>  PRT
<213>  Clostridium acetobutylicum 

<400>  290

Met Trp Gly Lys Ile Ile Met Gln Lys Ser Val Glu Ile Lys Ser Lys 
1               5                   10                  15      


Ser Leu Thr Leu Arg Gly Val Leu His Met Pro Leu Glu Ala Arg Glu 
            20                  25                  30          


Lys Leu Pro Ile Val Val Ile Tyr His Gly Phe Cys Gly Asn Lys Met 
        35                  40                  45              


Gly Pro His Phe Ile Phe Val Lys Leu Ala Arg Glu Leu Glu Lys Leu 
    50                  55                  60                  


Gly Ile Ala Thr Ile Arg Phe Asp Phe Ala Gly Thr Gly Glu Ser Asp 
65                  70                  75                  80  


Gly Glu Phe Val Asp Met Thr Phe Ser Asn Glu Val Tyr Asp Ala Asn 
                85                  90                  95      


Val Ile Leu Asp Tyr Val Lys Thr Leu Glu Phe Val Asp Lys Asp Arg 
            100                 105                 110         


Ile Ser Ile Leu Gly Phe Ser Met Gly Gly Ala Ile Ala Ser Val Ile 
        115                 120                 125             


Ala Gly Asp Arg Lys Asp Glu Ile Asn Thr Leu Cys Leu Trp Ala Pro 
    130                 135                 140                 


Ala Gly Asn Met Glu Gln Ile Ile Leu Ser Asp Thr Tyr Ile Gly Asp 
145                 150                 155                 160 


Lys Tyr Asp Glu Ile Met Glu Lys Gly Ile Tyr Asp Val Glu Gly Leu 
                165                 170                 175     


Leu Leu Gly Lys Lys Phe Leu Glu Asp Ile Lys Lys Val Asn Ile Phe 
            180                 185                 190         


Asp Arg Ala Ser Ala Tyr Asn Lys Gln Ser Leu Ile Ile His Gly Thr 
        195                 200                 205             


Ser Asp Glu Ile Val Pro Leu Ser Thr Ser Glu Arg Tyr Leu Glu Met 
    210                 215                 220                 


Tyr Gly Glu Asn Thr Ser Leu Glu Leu Val Glu Gly Ala Asn His Ile 
225                 230                 235                 240 


Phe Glu Lys Asn Ser Trp Glu Asn Arg Val Ile Asp Leu Thr Lys Lys 
                245                 250                 255     


Tyr Phe Ser Gly Lys Leu Val Lys Phe 
            260                 265 


<210>  291
<211>  236
<212>  PRT
<213>  Deinococcus radiodurans

<400>  291

Met Glu Met Phe Ala Gln Phe Ser Val Glu Gly Gln Arg Met Tyr Gly 
1               5                   10                  15      


Met Leu His Thr Pro Asp Gly Ser Ala Thr Gly Gln Gln Ala Pro Pro 
            20                  25                  30          


Gln Gly Trp Pro Ser Val Val Ile Val His Gly Phe Thr Gly Asp Lys 
        35                  40                  45              


Val Ser Ser His Arg Leu Leu Val Leu Leu Ala Arg Arg Leu Thr Ala 
    50                  55                  60                  


Ala Gly Ile Ala Ala Leu Arg Phe Asp Cys Arg Gly Ser Gly Glu Ser 
65                  70                  75                  80  


Gln Gly Asp Phe Ser Glu Met Thr Val Gly Arg Glu Val Gln Asp Val 
                85                  90                  95      


Glu Ala Ala Phe Asp Tyr Val Arg His Gln Pro Gly Leu Asp Pro Glu 
            100                 105                 110         


Arg Val Met Leu Leu Gly Tyr Ser Met Gly Gly Leu Val Ser Ala Leu 
        115                 120                 125             


Ala Ala Glu Lys Val Arg Pro His Arg Phe Ala Leu Trp Ser Pro Ala 
    130                 135                 140                 


Leu Pro Glu Leu Trp Leu Arg His Leu Arg Gly Gly Leu Leu Pro Pro 
145                 150                 155                 160 


Val Ile Ser Asp Tyr Gly Gly Trp Pro Leu Gly Arg Ala Phe Leu Gln 
                165                 170                 175     


Glu Val Val Gln Thr Arg Pro Leu Glu Ala Ala Ala Arg Trp Gly Gly 
            180                 185                 190         


Val Ala His Val Phe His Gly Asp Arg Asp Gln Thr Cys Pro Val Glu 
        195                 200                 205             


Trp Gly Val Arg Thr Pro Lys Pro Cys Ala Ala Thr Pro Pro Arg Phe 
    210                 215                 220                 


Pro Ala Arg Gly Thr Arg Met Thr Arg Ser Asn Arg 
225                 230                 235     


<210>  292
<211>  187
<212>  PRT
<213>  Lactobacillus acidophilus

<400>  292

Asp Phe Asn Gly His Gly Glu Ser Asp Gly Ala Phe Glu Asp Met Thr 
1               5                   10                  15      


Val Cys Asn Glu Ile Ala Asp Ala Gln Lys Ile Leu Glu Tyr Val Arg 
            20                  25                  30          


Thr Asp Pro His Val Arg Asn Ile Phe Leu Val Gly His Ser Gln Gly 
        35                  40                  45              


Gly Val Val Ala Ser Met Leu Ala Gly Leu Tyr Pro Asp Ile Val Lys 
    50                  55                  60                  


Lys Val Val Leu Leu Ala Pro Ala Ala Gln Leu Lys Asp Asp Ala Leu 
65                  70                  75                  80  


Asn Gly Asp Thr Gln Gly Ala Thr Tyr Asn Pro Glu His Ile Pro Ala 
                85                  90                  95      


Ala Ile Pro Phe His Gly Lys Lys Leu Gly Gly Phe Tyr Leu Arg Thr 
            100                 105                 110         


Ala Gln Val Leu Pro Ile Tyr Glu Ile Ala Lys His Tyr Thr Asn Pro 
        115                 120                 125             


Val Ser Ile Ile Val Gly Ser Asn Asp Gln Val Val Ala Pro Lys Tyr 
    130                 135                 140                 


Ser Lys Lys Tyr Asp Glu Val Tyr Glu Asn Ser Glu Leu His Met Val 
145                 150                 155                 160 


Pro Asp Ala Asp His Ser Phe Thr Gly Gln Tyr Lys Asp Ser Ala Val 
                165                 170                 175     


Asp Leu Thr Ala Glu Phe Leu Lys Pro Leu Phe 
            180                 185         


<210>  293
<211>  837
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 286

<400>  293
gtgcggaaac tgtcccattc ggggaaatcc atggcgattc cgccaaggga gcgtgttggg     60

atgcagaaag ccgtcgagct cgaggtggac ggtctcgtcc ttcgcggcat ggagcacgtg    120

ccggacgagg cagcgaaccg ccccgtgcct gccgccattc tgtttcacgg cttcacgggc    180

acacacatcg aacctcatca gctgtttgtc aagttgagcc gcgcgctcga ggccgagggg    240

gtggcggcgt ttcgcttcga tttcgccgga agcggggact ccgacggcga gtttcaggac    300

atgacagctt cttcggagat tcgagacgcg aaggcgattt tggactgggt gcggcgagat    360

ccccgcattg acccagaccg cgtgagcctc atcggcctca gcatgggagg ttacgtggcg    420

tccatcgtgg ccggggacga gccggacaag gtggacaggc tcgtgctgct tgcgccggcg    480

ggcaacatgg ccgacatcgc ggagaagcag gcggaggcgc tcggcgcggc ggccgacgcc    540

gacgtggtgg atctcggcgg gaacctcgtg ggccgcgggc tgtacgagga tctgaagcag    600

attgacgcat tcgagcgggc gaagccgttt cgcggcaagg tgctcatcat ccacgggatg    660

gaggatcagg ccgtcccgta cgaggtgtcg ctgaagtacc agaacgaggt ctacggcgaa    720

cgcgcgcggc ttcatctgat tgaagaggcg gatcacacgt tcaacaatcg gcactgggag    780

tccgaggtca ttcgggaaac cgtgcggttt ttgacggacg tggaccggtc gcaatga       837


<210>  294
<211>  837
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 286

<400>  294
gtgcggaaac tgtcccattc ggggaaatcc atggcgattc cgccaaggga gcgtgttggg     60

atgcagagag ccgtcgagat cgaggtggac ggtctcgtcc ttcgcggcat ggagcacgtg    120

ccggacgagg cagcgaaccg ccccgtgcct gccgccattc tgtttcacgg cttcacgggc    180

acacacatcg aacctcatca gctgtttgtc aagttgagcc gcgcgctcga ggccgagggg    240

gtggcggcgt ttcgcttcga tttcgccgga agcggggact ccgacggcga gtttcaggac    300

atgacagctt cttcggagat tcgagacgcg aaggcgattt tggactgggt gcggcgagat    360

ccccgcattg acccagaccg cgtgagcctc atcggcctca gcatgggagg ttacgtggcg    420

tccatcgtgg ccggggacga gccggacaag gtggacaggc tcgtgctgct tgcgccggcg    480

ggcaacatgg ccgacatcgc ggagaagcag gcggaggcgc tcggcgcggc ggccgacgcc    540

gacgtggtgg atctcggcgg gaacctcgtg ggccgcgggc tgtacgagga tctgaagcag    600

attgacgcat tcgagcgggc gaagccgttt cgcggcaagg tgctcatcat ccacgggatg    660

gaggatcagg ccgtcccgta cgaggtgtcg ctgaagtacc agaacgaggt ctacggcgaa    720

cgcgcgcggc ttcatctgat tgaagaggcg gatcacacgt tcaacaatcg gcactgggag    780

tccgaggtca ttcgggaaac cgtgcggttt ttgacggacg tggaccggtc gcaatga       837


<210>  295
<211>  837
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 286

<400>  295
gtgcggaaac tgtcccattc ggggaaatcc atggcgattc cgccaaggga gcgtgttggg     60

atgcagagag ccgtcgaggt cgaggtggac ggtctcgtcc ttcgcggcat ggagcacgtg    120

ccggacgagg cagcgaaccg ccccgtgcct gccgccattc tgtttcacgg cttcacgggc    180

acacacatcg aacctcatca gctgtttgtc aagttgagcc gcgcgctcga ggccgagggg    240

gtggcggcgt ttcgcttcga tttcgccgga agcggggact ccgacggcga gtttcaggac    300

atgacagctt cttcggagat tcgagacgcg aaggcgattt tggactgggt gcggcgagat    360

ccccgcattg acccagaccg cgtgagcctc atcggcctca gcatgggagg ttacgtggcg    420

tccatcgtgg ccggggacga gccggacaag gtggacaggc tcgtgctgct tgcgccggcg    480

ggcaacatgg ccgacatcgc ggagaagcag gcggaggcgc tcggcgcggc ggccgacgcc    540

gacgtggtgg atctcggcgg gaacctcgtg ggccgcgggc tgtacgagga tctgaagcag    600

attgacgcat tcgagcgggc gaagccgttt cgcggcaagg tgctcatcat ccacgggatg    660

gaggatcagg ccgtcccgta cgaggtgtcg ctgaagtacc agaacgaggt ctacggcgaa    720

cgcgcgcggc ttcatctgat tgaagaggcg gatcacacgt tcaacaatcg gcactgggag    780

tccgaggtca ttcgggaaac cgtgcggttt ttgacggacg tggaccggtc gcaatga       837


<210>  296
<211>  837
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 286

<400>  296
gtgcggaaac tgtcccattc ggggaaatcc atggcgattc cgccaaggga gcgtgttggg     60

atgcagagag ccgtcgagct cgagatagac ggtctcgtcc ttcgcggcat ggagcacgtg    120

ccggacgagg cagcgaaccg ccccgtgcct gccgccattc tgtttcacgg cttcacgggc    180

acacacatcg aacctcatca gctgtttgtc aagttgagcc gcgcgctcga ggccgagggg    240

gtggcggcgt ttcgcttcga tttcgccgga agcggggact ccgacggcga gtttcaggac    300

atgacagctt cttcggagat tcgagacgcg aaggcgattt tggactgggt gcggcgagat    360

ccccgcattg acccagaccg cgtgagcctc atcggcctca gcatgggagg ttacgtggcg    420

tccatcgtgg ccggggacga gccggacaag gtggacaggc tcgtgctgct tgcgccggcg    480

ggcaacatgg ccgacatcgc ggagaagcag gcggaggcgc tcggcgcggc ggccgacgcc    540

gacgtggtgg atctcggcgg gaacctcgtg ggccgcgggc tgtacgagga tctgaagcag    600

attgacgcat tcgagcgggc gaagccgttt cgcggcaagg tgctcatcat ccacgggatg    660

gaggatcagg ccgtcccgta cgaggtgtcg ctgaagtacc agaacgaggt ctacggcgaa    720

cgcgcgcggc ttcatctgat tgaagaggcg gatcacacgt tcaacaatcg gcactgggag    780

tccgaggtca ttcgggaaac cgtgcggttt ttgacggacg tggaccggtc gcaatga       837


<210>  297
<211>  837
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 286

<400>  297
gtgcggaaac tgtcccattc ggggaaatcc atggcgattc cgccaaggga gcgtgttggg     60

atgcagagag ccgtcgagct cgagctggac ggtctcgtcc ttcgcggcat ggagcacgtg    120

ccggacgagg cagcgaaccg ccccgtgcct gccgccattc tgtttcacgg cttcacgggc    180

acacacatcg aacctcatca gctgtttgtc aagttgagcc gcgcgctcga ggccgagggg    240

gtggcggcgt ttcgcttcga tttcgccgga agcggggact ccgacggcga gtttcaggac    300

atgacagctt cttcggagat tcgagacgcg aaggcgattt tggactgggt gcggcgagat    360

ccccgcattg acccagaccg cgtgagcctc atcggcctca gcatgggagg ttacgtggcg    420

tccatcgtgg ccggggacga gccggacaag gtggacaggc tcgtgctgct tgcgccggcg    480

ggcaacatgg ccgacatcgc ggagaagcag gcggaggcgc tcggcgcggc ggccgacgcc    540

gacgtggtgg atctcggcgg gaacctcgtg ggccgcgggc tgtacgagga tctgaagcag    600

attgacgcat tcgagcgggc gaagccgttt cgcggcaagg tgctcatcat ccacgggatg    660

gaggatcagg ccgtcccgta cgaggtgtcg ctgaagtacc agaacgaggt ctacggcgaa    720

cgcgcgcggc ttcatctgat tgaagaggcg gatcacacgt tcaacaatcg gcactgggag    780

tccgaggtca ttcgggaaac cgtgcggttt ttgacggacg tggaccggtc gcaatga       837


<210>  298
<211>  278
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:287 and encoded by SEQ ID NO:293

<400>  298

Met Arg Lys Leu Ser His Ser Gly Lys Ser Met Ala Ile Pro Pro Arg 
1               5                   10                  15      


Glu Arg Val Gly Met Gln Lys Ala Val Glu Leu Glu Val Asp Gly Leu 
            20                  25                  30          


Val Leu Arg Gly Met Glu His Val Pro Asp Glu Ala Ala Asn Arg Pro 
        35                  40                  45              


Val Pro Ala Ala Ile Leu Phe His Gly Phe Thr Gly Thr His Ile Glu 
    50                  55                  60                  


Pro His Gln Leu Phe Val Lys Leu Ser Arg Ala Leu Glu Ala Glu Gly 
65                  70                  75                  80  


Val Ala Ala Phe Arg Phe Asp Phe Ala Gly Ser Gly Asp Ser Asp Gly 
                85                  90                  95      


Glu Phe Gln Asp Met Thr Ala Ser Ser Glu Ile Arg Asp Ala Lys Ala 
            100                 105                 110         


Ile Leu Asp Trp Val Arg Arg Asp Pro Arg Ile Asp Pro Asp Arg Val 
        115                 120                 125             


Ser Leu Ile Gly Leu Ser Met Gly Gly Tyr Val Ala Ser Ile Val Ala 
    130                 135                 140                 


Gly Asp Glu Pro Asp Lys Val Asp Arg Leu Val Leu Leu Ala Pro Ala 
145                 150                 155                 160 


Gly Asn Met Ala Asp Ile Ala Glu Lys Gln Ala Glu Ala Leu Gly Ala 
                165                 170                 175     


Ala Ala Asp Ala Asp Val Val Asp Leu Gly Gly Asn Leu Val Gly Arg 
            180                 185                 190         


Gly Leu Tyr Glu Asp Leu Lys Gln Ile Asp Ala Phe Glu Arg Ala Lys 
        195                 200                 205             


Pro Phe Arg Gly Lys Val Leu Ile Ile His Gly Met Glu Asp Gln Ala 
    210                 215                 220                 


Val Pro Tyr Glu Val Ser Leu Lys Tyr Gln Asn Glu Val Tyr Gly Glu 
225                 230                 235                 240 


Arg Ala Arg Leu His Leu Ile Glu Glu Ala Asp His Thr Phe Asn Asn 
                245                 250                 255     


Arg His Trp Glu Ser Glu Val Ile Arg Glu Thr Val Arg Phe Leu Thr 
            260                 265                 270         


Asp Val Asp Arg Ser Gln 
        275             


<210>  299
<211>  278
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:287 and encoded by SEQ ID NO:294

<400>  299

Met Arg Lys Leu Ser His Ser Gly Lys Ser Met Ala Ile Pro Pro Arg 
1               5                   10                  15      


Glu Arg Val Gly Met Gln Arg Ala Val Glu Ile Glu Val Asp Gly Leu 
            20                  25                  30          


Val Leu Arg Gly Met Glu His Val Pro Asp Glu Ala Ala Asn Arg Pro 
        35                  40                  45              


Val Pro Ala Ala Ile Leu Phe His Gly Phe Thr Gly Thr His Ile Glu 
    50                  55                  60                  


Pro His Gln Leu Phe Val Lys Leu Ser Arg Ala Leu Glu Ala Glu Gly 
65                  70                  75                  80  


Val Ala Ala Phe Arg Phe Asp Phe Ala Gly Ser Gly Asp Ser Asp Gly 
                85                  90                  95      


Glu Phe Gln Asp Met Thr Ala Ser Ser Glu Ile Arg Asp Ala Lys Ala 
            100                 105                 110         


Ile Leu Asp Trp Val Arg Arg Asp Pro Arg Ile Asp Pro Asp Arg Val 
        115                 120                 125             


Ser Leu Ile Gly Leu Ser Met Gly Gly Tyr Val Ala Ser Ile Val Ala 
    130                 135                 140                 


Gly Asp Glu Pro Asp Lys Val Asp Arg Leu Val Leu Leu Ala Pro Ala 
145                 150                 155                 160 


Gly Asn Met Ala Asp Ile Ala Glu Lys Gln Ala Glu Ala Leu Gly Ala 
                165                 170                 175     


Ala Ala Asp Ala Asp Val Val Asp Leu Gly Gly Asn Leu Val Gly Arg 
            180                 185                 190         


Gly Leu Tyr Glu Asp Leu Lys Gln Ile Asp Ala Phe Glu Arg Ala Lys 
        195                 200                 205             


Pro Phe Arg Gly Lys Val Leu Ile Ile His Gly Met Glu Asp Gln Ala 
    210                 215                 220                 


Val Pro Tyr Glu Val Ser Leu Lys Tyr Gln Asn Glu Val Tyr Gly Glu 
225                 230                 235                 240 


Arg Ala Arg Leu His Leu Ile Glu Glu Ala Asp His Thr Phe Asn Asn 
                245                 250                 255     


Arg His Trp Glu Ser Glu Val Ile Arg Glu Thr Val Arg Phe Leu Thr 
            260                 265                 270         


Asp Val Asp Arg Ser Gln 
        275             


<210>  300
<211>  278
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:287 and encoded by SEQ ID NO:295

<400>  300

Met Arg Lys Leu Ser His Ser Gly Lys Ser Met Ala Ile Pro Pro Arg 
1               5                   10                  15      


Glu Arg Val Gly Met Gln Arg Ala Val Glu Val Glu Val Asp Gly Leu 
            20                  25                  30          


Val Leu Arg Gly Met Glu His Val Pro Asp Glu Ala Ala Asn Arg Pro 
        35                  40                  45              


Val Pro Ala Ala Ile Leu Phe His Gly Phe Thr Gly Thr His Ile Glu 
    50                  55                  60                  


Pro His Gln Leu Phe Val Lys Leu Ser Arg Ala Leu Glu Ala Glu Gly 
65                  70                  75                  80  


Val Ala Ala Phe Arg Phe Asp Phe Ala Gly Ser Gly Asp Ser Asp Gly 
                85                  90                  95      


Glu Phe Gln Asp Met Thr Ala Ser Ser Glu Ile Arg Asp Ala Lys Ala 
            100                 105                 110         


Ile Leu Asp Trp Val Arg Arg Asp Pro Arg Ile Asp Pro Asp Arg Val 
        115                 120                 125             


Ser Leu Ile Gly Leu Ser Met Gly Gly Tyr Val Ala Ser Ile Val Ala 
    130                 135                 140                 


Gly Asp Glu Pro Asp Lys Val Asp Arg Leu Val Leu Leu Ala Pro Ala 
145                 150                 155                 160 


Gly Asn Met Ala Asp Ile Ala Glu Lys Gln Ala Glu Ala Leu Gly Ala 
                165                 170                 175     


Ala Ala Asp Ala Asp Val Val Asp Leu Gly Gly Asn Leu Val Gly Arg 
            180                 185                 190         


Gly Leu Tyr Glu Asp Leu Lys Gln Ile Asp Ala Phe Glu Arg Ala Lys 
        195                 200                 205             


Pro Phe Arg Gly Lys Val Leu Ile Ile His Gly Met Glu Asp Gln Ala 
    210                 215                 220                 


Val Pro Tyr Glu Val Ser Leu Lys Tyr Gln Asn Glu Val Tyr Gly Glu 
225                 230                 235                 240 


Arg Ala Arg Leu His Leu Ile Glu Glu Ala Asp His Thr Phe Asn Asn 
                245                 250                 255     


Arg His Trp Glu Ser Glu Val Ile Arg Glu Thr Val Arg Phe Leu Thr 
            260                 265                 270         


Asp Val Asp Arg Ser Gln 
        275             


<210>  301
<211>  278
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:287 and encoded by SEQ ID NO:296

<400>  301

Met Arg Lys Leu Ser His Ser Gly Lys Ser Met Ala Ile Pro Pro Arg 
1               5                   10                  15      


Glu Arg Val Gly Met Gln Arg Ala Val Glu Leu Glu Ile Asp Gly Leu 
            20                  25                  30          


Val Leu Arg Gly Met Glu His Val Pro Asp Glu Ala Ala Asn Arg Pro 
        35                  40                  45              


Val Pro Ala Ala Ile Leu Phe His Gly Phe Thr Gly Thr His Ile Glu 
    50                  55                  60                  


Pro His Gln Leu Phe Val Lys Leu Ser Arg Ala Leu Glu Ala Glu Gly 
65                  70                  75                  80  


Val Ala Ala Phe Arg Phe Asp Phe Ala Gly Ser Gly Asp Ser Asp Gly 
                85                  90                  95      


Glu Phe Gln Asp Met Thr Ala Ser Ser Glu Ile Arg Asp Ala Lys Ala 
            100                 105                 110         


Ile Leu Asp Trp Val Arg Arg Asp Pro Arg Ile Asp Pro Asp Arg Val 
        115                 120                 125             


Ser Leu Ile Gly Leu Ser Met Gly Gly Tyr Val Ala Ser Ile Val Ala 
    130                 135                 140                 


Gly Asp Glu Pro Asp Lys Val Asp Arg Leu Val Leu Leu Ala Pro Ala 
145                 150                 155                 160 


Gly Asn Met Ala Asp Ile Ala Glu Lys Gln Ala Glu Ala Leu Gly Ala 
                165                 170                 175     


Ala Ala Asp Ala Asp Val Val Asp Leu Gly Gly Asn Leu Val Gly Arg 
            180                 185                 190         


Gly Leu Tyr Glu Asp Leu Lys Gln Ile Asp Ala Phe Glu Arg Ala Lys 
        195                 200                 205             


Pro Phe Arg Gly Lys Val Leu Ile Ile His Gly Met Glu Asp Gln Ala 
    210                 215                 220                 


Val Pro Tyr Glu Val Ser Leu Lys Tyr Gln Asn Glu Val Tyr Gly Glu 
225                 230                 235                 240 


Arg Ala Arg Leu His Leu Ile Glu Glu Ala Asp His Thr Phe Asn Asn 
                245                 250                 255     


Arg His Trp Glu Ser Glu Val Ile Arg Glu Thr Val Arg Phe Leu Thr 
            260                 265                 270         


Asp Val Asp Arg Ser Gln 
        275             


<210>  302
<211>  278
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:287 and encoded by SEQ ID NO:297

<400>  302

Met Arg Lys Leu Ser His Ser Gly Lys Ser Met Ala Ile Pro Pro Arg 
1               5                   10                  15      


Glu Arg Val Gly Met Gln Arg Ala Val Glu Leu Glu Leu Asp Gly Leu 
            20                  25                  30          


Val Leu Arg Gly Met Glu His Val Pro Asp Glu Ala Ala Asn Arg Pro 
        35                  40                  45              


Val Pro Ala Ala Ile Leu Phe His Gly Phe Thr Gly Thr His Ile Glu 
    50                  55                  60                  


Pro His Gln Leu Phe Val Lys Leu Ser Arg Ala Leu Glu Ala Glu Gly 
65                  70                  75                  80  


Val Ala Ala Phe Arg Phe Asp Phe Ala Gly Ser Gly Asp Ser Asp Gly 
                85                  90                  95      


Glu Phe Gln Asp Met Thr Ala Ser Ser Glu Ile Arg Asp Ala Lys Ala 
            100                 105                 110         


Ile Leu Asp Trp Val Arg Arg Asp Pro Arg Ile Asp Pro Asp Arg Val 
        115                 120                 125             


Ser Leu Ile Gly Leu Ser Met Gly Gly Tyr Val Ala Ser Ile Val Ala 
    130                 135                 140                 


Gly Asp Glu Pro Asp Lys Val Asp Arg Leu Val Leu Leu Ala Pro Ala 
145                 150                 155                 160 


Gly Asn Met Ala Asp Ile Ala Glu Lys Gln Ala Glu Ala Leu Gly Ala 
                165                 170                 175     


Ala Ala Asp Ala Asp Val Val Asp Leu Gly Gly Asn Leu Val Gly Arg 
            180                 185                 190         


Gly Leu Tyr Glu Asp Leu Lys Gln Ile Asp Ala Phe Glu Arg Ala Lys 
        195                 200                 205             


Pro Phe Arg Gly Lys Val Leu Ile Ile His Gly Met Glu Asp Gln Ala 
    210                 215                 220                 


Val Pro Tyr Glu Val Ser Leu Lys Tyr Gln Asn Glu Val Tyr Gly Glu 
225                 230                 235                 240 


Arg Ala Arg Leu His Leu Ile Glu Glu Ala Asp His Thr Phe Asn Asn 
                245                 250                 255     


Arg His Trp Glu Ser Glu Val Ile Arg Glu Thr Val Arg Phe Leu Thr 
            260                 265                 270         


Asp Val Asp Arg Ser Gln 
        275             


<210>  303
<211>  1473
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  303
atggacgtga tcgtcgagac gcgatacggc aaggtgatgg ggcgagaaga ggatggggtt     60

cgcgtgtttt taggcgtccc gtacgcgaag gcgccgcagg gcgaacggag attcttgccg    120

ccggagccgg tcgagccatg ggccgacgtg ctggatgcgc gcgcacacgg gcccatctgt    180

ccacaggtgg ccaatccgct gaaccctgtc gacggtttcg tgcagtccga ggattgcctg    240

cggttgaaca tctacgcgcc agccgagggg acgggccacc ctgtgatggt ctggatccac    300

ggcggcgcgt tcgtgtttgg atcgggccag tctccgtggt acgacgggcg cgcgtttgcg    360

agagacggcg tggtgctcgt gagcatcaac taccgcctcg gcccgctcgg ctttctgcac    420

ctcgcccacc tcggcggcga agcctatgcg agctcgggca acgcgggcat tttggaccag    480

gttgccgcgc tcacgtttgt gcgcgacacg attgaggcgt ttgggggcga cccgaaccgg    540

gtgacggtag cgggcgaatc ggccggcgcg tggagcgtcg gcacgctttt ggtgatggaa    600

tcggcgcgag ggttgttcca gcaggccatt ctgcagagcg gcattccgtt tgcgtatcgg    660

acgcccgagt ttgcggagtg gtggaccact cagctgctcg atgcgctcgg catcaaccag    720

gcgtcgtggc atcgcctctt cgacgttccc gccgccgatc tcgtcgcggc cgcagcacgc    780

attcccgcgc gggatgggct gaatctgcgc ccggtcttgg acggcgtgac gctcacgcgg    840

tcattctggg atgcgctgcg agaagggcag gccgcgcacg tgcccaccct cgccggatcg    900

aatcgggagg agctgatgtt gtggatggcc cgcgatcccg agtggcgcac gctttccgac    960

gaggaacgca tcgcgcgcgt ggatcgcatg tgggggccac tcggcgatcg cgcccgagac   1020

tactacgtgg atggccgcac gggcgacgaa ctggaaacgt ggctcgtccg attcgcctcc   1080

atgcggagtt tcacgtatcc gaccatccgc gcggccgaga ttcagagcga atacgccccc   1140

gtctatctgt accggtttga ctacaggccc agtcagctgg gcgcggccca cgcgctcgaa   1200

atcccgttcg tgttcggcac gtatgcccat ccgtcggcgc gggtgctcgt cggagaccgg   1260

ccttcgcatg ccgccgtctc ggacgcgatg cacgcggctt gggtggcgtt cgtccgccat   1320

ggaagcccgc aggcgccgca cctcccggag tggccgacct acgacccgaa gcgccgctcg   1380

accatgattt tcgacgaaac gtctcgcgtc gaggaggatc ccgataccgc cgagcgcgag   1440

ctctggtccg agatgatgag cctgtcgatg tga                                1473


<210>  304
<211>  490
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  304

Met Asp Val Ile Val Glu Thr Arg Tyr Gly Lys Val Met Gly Arg Glu 
1               5                   10                  15      


Glu Asp Gly Val Arg Val Phe Leu Gly Val Pro Tyr Ala Lys Ala Pro 
            20                  25                  30          


Gln Gly Glu Arg Arg Phe Leu Pro Pro Glu Pro Val Glu Pro Trp Ala 
        35                  40                  45              


Asp Val Leu Asp Ala Arg Ala His Gly Pro Ile Cys Pro Gln Val Ala 
    50                  55                  60                  


Asn Pro Leu Asn Pro Val Asp Gly Phe Val Gln Ser Glu Asp Cys Leu 
65                  70                  75                  80  


Arg Leu Asn Ile Tyr Ala Pro Ala Glu Gly Thr Gly His Pro Val Met 
                85                  90                  95      


Val Trp Ile His Gly Gly Ala Phe Val Phe Gly Ser Gly Gln Ser Pro 
            100                 105                 110         


Trp Tyr Asp Gly Arg Ala Phe Ala Arg Asp Gly Val Val Leu Val Ser 
        115                 120                 125             


Ile Asn Tyr Arg Leu Gly Pro Leu Gly Phe Leu His Leu Ala His Leu 
    130                 135                 140                 


Gly Gly Glu Ala Tyr Ala Ser Ser Gly Asn Ala Gly Ile Leu Asp Gln 
145                 150                 155                 160 


Val Ala Ala Leu Thr Phe Val Arg Asp Thr Ile Glu Ala Phe Gly Gly 
                165                 170                 175     


Asp Pro Asn Arg Val Thr Val Ala Gly Glu Ser Ala Gly Ala Trp Ser 
            180                 185                 190         


Val Gly Thr Leu Leu Val Met Glu Ser Ala Arg Gly Leu Phe Gln Gln 
        195                 200                 205             


Ala Ile Leu Gln Ser Gly Ile Pro Phe Ala Tyr Arg Thr Pro Glu Phe 
    210                 215                 220                 


Ala Glu Trp Trp Thr Thr Gln Leu Leu Asp Ala Leu Gly Ile Asn Gln 
225                 230                 235                 240 


Ala Ser Trp His Arg Leu Phe Asp Val Pro Ala Ala Asp Leu Val Ala 
                245                 250                 255     


Ala Ala Ala Arg Ile Pro Ala Arg Asp Gly Leu Asn Leu Arg Pro Val 
            260                 265                 270         


Leu Asp Gly Val Thr Leu Thr Arg Ser Phe Trp Asp Ala Leu Arg Glu 
        275                 280                 285             


Gly Gln Ala Ala His Val Pro Thr Leu Ala Gly Ser Asn Arg Glu Glu 
    290                 295                 300                 


Leu Met Leu Trp Met Ala Arg Asp Pro Glu Trp Arg Thr Leu Ser Asp 
305                 310                 315                 320 


Glu Glu Arg Ile Ala Arg Val Asp Arg Met Trp Gly Pro Leu Gly Asp 
                325                 330                 335     


Arg Ala Arg Asp Tyr Tyr Val Asp Gly Arg Thr Gly Asp Glu Leu Glu 
            340                 345                 350         


Thr Trp Leu Val Arg Phe Ala Ser Met Arg Ser Phe Thr Tyr Pro Thr 
        355                 360                 365             


Ile Arg Ala Ala Glu Ile Gln Ser Glu Tyr Ala Pro Val Tyr Leu Tyr 
    370                 375                 380                 


Arg Phe Asp Tyr Arg Pro Ser Gln Leu Gly Ala Ala His Ala Leu Glu 
385                 390                 395                 400 


Ile Pro Phe Val Phe Gly Thr Tyr Ala His Pro Ser Ala Arg Val Leu 
                405                 410                 415     


Val Gly Asp Arg Pro Ser His Ala Ala Val Ser Asp Ala Met His Ala 
            420                 425                 430         


Ala Trp Val Ala Phe Val Arg His Gly Ser Pro Gln Ala Pro His Leu 
        435                 440                 445             


Pro Glu Trp Pro Thr Tyr Asp Pro Lys Arg Arg Ser Thr Met Ile Phe 
    450                 455                 460                 


Asp Glu Thr Ser Arg Val Glu Glu Asp Pro Asp Thr Ala Glu Arg Glu 
465                 470                 475                 480 


Leu Trp Ser Glu Met Met Ser Leu Ser Met 
                485                 490 


<210>  305
<211>  499
<212>  PRT
<213>  Geobacillus kaustophilus

<400>  305

Met Glu Arg Thr Val Val Glu Thr Arg Tyr Gly Arg Leu Arg Gly Val 
1               5                   10                  15      


Val Asn Gly Ser Val Phe Val Trp Lys Gly Ile Pro Tyr Ala Lys Ala 
            20                  25                  30          


Pro Val Gly Glu Arg Arg Phe Leu Pro Pro Glu Pro Pro Asp Ala Trp 
        35                  40                  45              


Asp Gly Val Arg Glu Ala Ala Ala Phe Gly Pro Val Val Met Gln Pro 
    50                  55                  60                  


Ser Asp Pro Ile Phe Ser Gly Leu Leu Gly Arg Met Ser Glu Ala Pro 
65                  70                  75                  80  


Ser Glu Asp Gly Leu Tyr Leu Asn Ile Trp Ser Pro Ala Ala Asp Gly 
                85                  90                  95      


Lys Lys Arg Pro Val Leu Phe Trp Ile His Gly Gly Ala Phe Leu Phe 
            100                 105                 110         


Gly Ser Gly Ser Ser Pro Trp Tyr Asp Gly Thr Ala Leu Ala Lys His 
        115                 120                 125             


Gly Asp Val Val Val Val Thr Ile Asn Tyr Arg Met Asn Val Phe Gly 
    130                 135                 140                 


Phe Leu His Leu Gly Asp Leu Phe Gly Glu Ala Tyr Ala Gln Ala Gly 
145                 150                 155                 160 


Asn Leu Gly Ile Leu Asp Gln Val Ala Ala Leu Arg Trp Val Lys Glu 
                165                 170                 175     


Asn Ile Glu Ala Phe Gly Gly Asp Pro Asp Asn Ile Thr Ile Phe Gly 
            180                 185                 190         


Glu Ser Ala Gly Ala Ala Ser Val Gly Val Leu Leu Ser Leu Ser Glu 
        195                 200                 205             


Ala Ser Gly Leu Phe Arg Arg Ala Ile Leu Gln Ser Gly Ser Gly Ala 
    210                 215                 220                 


Leu Leu Leu Arg Ser Pro Lys Thr Ala Met Ala Met Thr Glu Arg Ile 
225                 230                 235                 240 


Leu Glu Arg Ala Gly Ile Arg Pro Gly Asp Arg Gly Arg Leu Leu Ser 
                245                 250                 255     


Ile Pro Ala Glu Glu Leu Leu Arg Ser Ala Leu Ser Leu Gly Pro Gly 
            260                 265                 270         


Ile Met Tyr Gly Pro Val Val Asp Gly Arg Val Leu Arg Arg His Pro 
        275                 280                 285             


Ile Glu Ala Leu Cys Asp Gly Ala Ala Ser Gly Ile Pro Ile Leu Ile 
    290                 295                 300                 


Gly Val Thr Lys Asp Glu Tyr Asn Leu Phe Thr Leu Thr Asp Pro Ser 
305                 310                 315                 320 


Trp Met Lys Leu Gly Glu His Glu Leu Leu Asp Arg Ile Asn Arg Glu 
                325                 330                 335     


Val Gly Pro Val Pro Glu Ala Ala Ile Arg Tyr Tyr Ala Glu Thr Ala 
            340                 345                 350         


Glu Pro Ser Ala Pro Asp Trp Gln Thr Trp Leu Arg Ile Met Thr Tyr 
        355                 360                 365             


Arg Val Phe Val Glu Gly Met Leu Arg Thr Ala Asp Ala Gln Ala Ala 
    370                 375                 380                 


His Gly Ala Asp Val Tyr Met Tyr Arg Phe Asp Tyr Glu Thr Pro Val 
385                 390                 395                 400 


Phe Gly Gly Gln Leu Lys Ala Cys His Ala Leu Glu Leu Pro Phe Val 
                405                 410                 415     


Phe His Asn Leu His Gln Pro Gly Val Ala Asn Phe Val Gly Asn Arg 
            420                 425                 430         


Pro Glu Arg Glu Ala Ile Ala Asn Glu Met His Tyr Ala Trp Leu Ser 
        435                 440                 445             


Phe Ala Arg Thr Gly Asp Pro Asn Gly Ala His Leu Pro Glu Lys Trp 
    450                 455                 460                 


Pro Ile Tyr Thr Asn Glu Arg Lys Pro Val Phe Val Phe Ser Ala Ala 
465                 470                 475                 480 


Ser His Val Glu Asp Asp Pro Phe Gly Cys Glu Arg Ala Ala Trp Met 
                485                 490                 495     


Thr Arg Ala 
            


<210>  306
<211>  498
<212>  PRT
<213>  Geobacillus stearothermophilus

<400>  306

Met Glu Arg Thr Val Val Glu Thr Arg Tyr Gly Arg Leu Arg Gly Glu 
1               5                   10                  15      


Met Asn Glu Gly Val Phe Val Trp Lys Gly Ile Pro Tyr Ala Lys Ala 
            20                  25                  30          


Pro Val Gly Glu Arg Arg Phe Leu Pro Pro Glu Pro Pro Asp Ala Trp 
        35                  40                  45              


Asp Gly Val Arg Glu Ala Thr Ser Phe Gly Pro Val Val Met Gln Pro 
    50                  55                  60                  


Ser Asp Pro Ile Phe Ser Gly Leu Leu Gly Arg Met Ser Glu Ala Pro 
65                  70                  75                  80  


Ser Glu Asp Gly Leu Tyr Leu Asn Ile Trp Ser Pro Ala Ala Asp Gly 
                85                  90                  95      


Lys Lys Arg Pro Val Leu Phe Trp Ile His Gly Gly Ala Phe Leu Phe 
            100                 105                 110         


Gly Ser Gly Ser Ser Pro Trp Tyr Asp Gly Thr Ala Phe Ala Lys His 
        115                 120                 125             


Gly Asp Val Val Val Val Thr Ile Asn Tyr Arg Met Asn Val Phe Gly 
    130                 135                 140                 


Phe Leu His Leu Gly Asp Ser Phe Gly Glu Ala Tyr Ala Gln Ala Gly 
145                 150                 155                 160 


Asn Leu Gly Ile Leu Asp Gln Val Ala Ala Leu Arg Trp Val Lys Glu 
                165                 170                 175     


Asn Ile Ala Ala Phe Gly Gly Asp Pro Asp Asn Ile Thr Ile Phe Gly 
            180                 185                 190         


Glu Ser Ala Gly Ala Ala Ser Val Gly Val Leu Leu Ser Leu Pro Glu 
        195                 200                 205             


Ala Ser Gly Leu Phe Arg Arg Ala Met Leu Gln Ser Gly Ser Gly Ser 
    210                 215                 220                 


Leu Leu Leu Arg Ser Pro Glu Thr Ala Met Ala Met Thr Glu Arg Ile 
225                 230                 235                 240 


Leu Asp Lys Ala Gly Ile Arg Pro Gly Asp Arg Glu Arg Leu Leu Ser 
                245                 250                 255     


Ile Pro Ala Glu Glu Leu Leu Arg Ala Ala Leu Ser Leu Gly Pro Gly 
            260                 265                 270         


Val Met Tyr Gly Pro Val Val Asp Gly Arg Val Leu Arg Arg His Pro 
        275                 280                 285             


Ile Glu Ala Leu Arg Tyr Gly Ala Ala Ser Gly Ile Pro Ile Leu Ile 
    290                 295                 300                 


Gly Val Thr Lys Asp Glu Tyr Asn Leu Phe Thr Leu Thr Asp Pro Ser 
305                 310                 315                 320 


Trp Thr Lys Leu Gly Glu Lys Glu Leu Leu Asp Arg Ile Asn Arg Glu 
                325                 330                 335     


Val Gly Pro Val Pro Glu Glu Ala Ile Arg Tyr Tyr Lys Glu Thr Ala 
            340                 345                 350         


Glu Pro Ser Ala Pro Thr Trp Gln Thr Trp Leu Arg Ile Met Thr Tyr 
        355                 360                 365             


Arg Val Phe Val Glu Gly Met Leu Arg Thr Ala Asp Ala Gln Ala Ala 
    370                 375                 380                 


Gln Gly Ala Asp Val Tyr Met Tyr Arg Phe Asp Tyr Glu Thr Pro Val 
385                 390                 395                 400 


Phe Gly Gly Gln Leu Lys Ala Cys His Ala Leu Glu Leu Pro Phe Val 
                405                 410                 415     


Phe His Asn Leu His Gln Pro Gly Val Ala Asn Phe Val Gly Asn Arg 
            420                 425                 430         


Pro Glu Arg Glu Ala Ile Ala Asn Glu Met His Tyr Ala Trp Leu Ser 
        435                 440                 445             


Phe Ala Arg Thr Gly Asp Pro Asn Gly Ala His Leu Pro Glu Ala Trp 
    450                 455                 460                 


Pro Ala Tyr Thr Asn Glu Arg Lys Ala Ala Phe Val Phe Ser Ala Ala 
465                 470                 475                 480 


Ser His Val Glu Asp Asp Pro Phe Gly Arg Glu Arg Ala Ala Trp Gln 
                485                 490                 495     


Gly Arg 
        


<210>  307
<211>  491
<212>  PRT
<213>  Bacillus coagulans

<400>  307

Met Lys Thr Ala Ile Val Glu Thr Val Phe Gly Lys Ala Arg Gly Tyr 
1               5                   10                  15      


Glu Glu Lys Gly Val Gln Ile Trp Lys Gly Ile Pro Tyr Ala Lys Pro 
            20                  25                  30          


Pro Ile Gly Pro Leu Arg Phe Arg Pro Pro Glu Leu Pro Glu Pro Trp 
        35                  40                  45              


Ala Gly Val Lys Asp Cys Thr Gln Phe Gly Pro Ile Ala Trp Gln Pro 
    50                  55                  60                  


Pro Val Glu Leu Met Asp Phe Leu Gly Asn Pro Ala Glu Asn Met Asp 
65                  70                  75                  80  


Glu Asp Cys Leu Asn Leu Asn Ile Trp Thr Pro Gly Ala Asp Gly Glu 
                85                  90                  95      


Arg Arg Pro Val Met Val Trp Ile His Gly Gly Ala Phe Ala Asn Gly 
            100                 105                 110         


Ala Gly Ser Ala Pro Ser Tyr Asp Gly Ser Ala Phe Ala Lys Asn Gly 
        115                 120                 125             


Asp Val Val Val Val Thr Ile Asn Tyr Arg Leu Gly Ala Leu Gly Phe 
    130                 135                 140                 


Leu Tyr Leu Gly Glu Met Gly Gly Glu Tyr Glu Ala Ser Gly Asn Cys 
145                 150                 155                 160 


Gly Ile Leu Asp Gln Ile Ala Ala Leu Lys Trp Val Lys Glu Asn Ile 
                165                 170                 175     


Ala Ala Phe Gly Gly Asp Pro Asp Cys Val Thr Ile Phe Gly Glu Ser 
            180                 185                 190         


Ala Gly Ala Met Ser Val Ala Ala Leu Leu Ser Ser Pro Ala Ala Ser 
        195                 200                 205             


Gly Leu Phe His Lys Ala Ile Leu Glu Ser Gly Ala Ala Asn Phe Thr 
    210                 215                 220                 


Ala Thr Pro Glu Arg Ala Ala Lys Asn Ala Arg Arg Ile Leu Glu Thr 
225                 230                 235                 240 


Leu Gly Leu Glu Lys Lys Asp Val Ala Lys Leu Ala Glu Val Pro Ala 
                245                 250                 255     


Lys Asn Leu Ala Glu Ala Val Asn Ser Leu Pro Phe Met Ser Leu Leu 
            260                 265                 270         


Pro Val Thr Asp Gly Ile Val Leu Pro Glu His Pro Glu Arg Ala Leu 
        275                 280                 285             


Glu Asn Ala Ala Lys Asp Ile Pro Val Leu Ile Gly Thr Asn Lys Asp 
    290                 295                 300                 


Glu Tyr Arg Leu Phe Thr Val Phe Asp Pro Val Trp Lys Arg Gln Asp 
305                 310                 315                 320 


Pro Lys Glu Met Gln Asp Val Phe Gln Lys Thr Phe Ala Lys Tyr Trp 
                325                 330                 335     


Asp Ala Leu Ser Ala Lys Ile Thr Asp Pro Ser Ala Phe Thr Gln Glu 
            340                 345                 350         


Leu Tyr Asp Arg Ile Met Thr Tyr Phe Val Phe Thr Gly Pro Ala Leu 
        355                 360                 365             


Lys Leu Ala Asp Thr Arg Ala Gln Thr Gly Glu Lys Val Trp Met Tyr 
    370                 375                 380                 


Gln Phe Asp Trp Glu Ser Pro Val Tyr Asn Gly Thr Leu Lys Ala Cys 
385                 390                 395                 400 


His Ala Leu Glu Ile Pro Phe Val Trp His Thr Leu Glu Gln Pro Gly 
                405                 410                 415     


Thr Glu Asn Leu Thr Gly Asn Ala Pro Gly Arg His Ala Leu Ala Asp 
            420                 425                 430         


Gln Met His Gln Ala Trp Ile Ala Phe Ala Gln Asn Gly Asp Pro Asn 
        435                 440                 445             


Cys Ser Leu Leu Pro Glu Trp Pro Pro Tyr Asn Thr Arg Gln Arg Pro 
    450                 455                 460                 


Ala Met Ile Phe Gly Gln Asp Cys Arg Val Glu Lys Asp Pro His Gln 
465                 470                 475                 480 


Ala Glu Arg Ala Leu Trp Gly Gly Leu Gly Glu 
                485                 490     


<210>  308
<211>  495
<212>  PRT
<213>  Bacillus niacini

<400>  308

Met Thr Lys Thr Ile Val Gly Ser Val Tyr Gly Lys Leu Gln Gly Glu 
1               5                   10                  15      


Gln Val Asp Gly Val Cys Ser Trp Lys Gly Val Pro Tyr Ala Lys Pro 
            20                  25                  30          


Pro Val Gly Ala Leu Arg Phe Arg Ala Pro Glu Arg Pro Asp Ser Trp 
        35                  40                  45              


Glu Gly Val Arg Gln Ala Thr Ser Phe Ser Pro Val Ala Pro Gln Thr 
    50                  55                  60                  


Gln Arg Glu Ile Met Glu Phe Phe Gly Asn Asp Ile Ser Asn Met Asn 
65                  70                  75                  80  


Glu Asp Cys Leu Tyr Leu Asn Val Trp Ser Pro Gly Ala Asp Asp Lys 
                85                  90                  95      


Lys Arg Pro Val Met Val Trp Ile His Gly Gly Ala Phe Val Ser Gly 
            100                 105                 110         


Ser Gly Ser Ser Ser Trp Tyr Asp Gly Ala Ser Phe Ala Ala Gln Gly 
        115                 120                 125             


Asp Val Val Val Val Thr Ile Asn Tyr Arg Leu Gly Ile Leu Gly Phe 
    130                 135                 140                 


Leu His Leu Gly Glu Ile Gly Gly Glu Glu Tyr Ala Thr Ser Gly Asn 
145                 150                 155                 160 


Cys Gly Ile Leu Asp Gln Val Ala Ala Leu Gln Trp Val Gln Glu Asn 
                165                 170                 175     


Ile Ala Ser Phe Gly Gly Asp Pro Asn Asn Val Thr Val Phe Gly Glu 
            180                 185                 190         


Ser Ala Gly Ala Met Ser Ile Gly Val Leu Leu Gly Phe Pro Ser Ala 
        195                 200                 205             


Gln Gly Leu Phe His Asn Ala Ile Leu Gln Ser Gly Ala Ala Ala Asn 
    210                 215                 220                 


Val His Ser Ser Glu Thr Ala Thr Lys Val Ala Gly His Leu Leu Ala 
225                 230                 235                 240 


Ala Leu Gln Val Glu Pro Thr Asn Leu Ser Lys Leu Glu Glu Leu Ser 
                245                 250                 255     


Val Glu Gln Leu Ile Gln Val Ala Asp Leu Val Pro Pro Met Ser Leu 
            260                 265                 270         


Gly Pro Val Ile Asp Gly Val Ser Leu Pro Lys His Pro Gln Glu Ala 
        275                 280                 285             


Ile Ala Asp Gly Ser Ala Lys Asp Val Ser Ile Leu Val Gly Thr Asn 
    290                 295                 300                 


Lys Asp Glu Tyr Asn Ile Phe Ser Val Phe Asp Pro Glu Trp Lys Asn 
305                 310                 315                 320 


Ala Asp Glu Ala Lys Val Thr Ala Leu Phe Glu Lys Thr Phe Gly Pro 
                325                 330                 335     


Leu Val Gln Val Ile Ser Lys Phe Ile Pro Gly Gly Leu Asn Gln Asp 
            340                 345                 350         


Leu Phe Asn Lys Leu Leu Thr Asp Thr Ile Phe Thr Asn Pro Ala Gln 
        355                 360                 365             


Lys Leu Ala Glu Leu Gln Val Asn Gln Gly Thr Pro Val Trp Met Tyr 
    370                 375                 380                 


Arg Phe Asp Trp Glu Thr Pro Val Phe Gly Gly Ala Leu Lys Ser Thr 
385                 390                 395                 400 


His Ala Leu Glu Ile Pro Phe Val Phe Asn Thr Leu Arg Thr Pro Asn 
                405                 410                 415     


Thr Glu Asn Phe Thr Gly Ser Ser Pro Glu Arg Gln Gln Ile Ala Asp 
            420                 425                 430         


Gln Met His Gln Arg Trp Ile Asn Phe Ala Lys Ser Gly His Pro Asn 
        435                 440                 445             


Ser Asp Arg Leu Leu Glu Trp Pro Ser Tyr Asp Met Asn Asn Arg Ser 
    450                 455                 460                 


Thr Met Ile Phe Asn Asn Glu Ser Ile Val Val Asn Asp Pro Asn Arg 
465                 470                 475                 480 


Glu Asp Arg Leu Lys Trp Glu Gln Leu Ser Met Val Met Lys Gly 
                485                 490                 495 


<210>  309
<211>  499
<212>  PRT
<213>  Geobacillus thermodenitrificans

<400>  309

Met Gly Thr Val Ile Val Glu Thr Lys Tyr Gly Arg Leu Arg Gly Gly 
1               5                   10                  15      


Thr Asn Glu Gly Val Phe Tyr Trp Lys Gly Ile Pro Tyr Ala Lys Ala 
            20                  25                  30          


Pro Val Gly Glu Arg Arg Phe Leu Pro Pro Glu Pro Pro Asp Ala Trp 
        35                  40                  45              


Asp Gly Val Arg Glu Ala Thr Ser Phe Gly Pro Val Val Met Gln Pro 
    50                  55                  60                  


Ser Asp Ser Met Phe Ser Gln Leu Leu Gly Arg Met Asn Glu Pro Met 
65                  70                  75                  80  


Ser Glu Asp Gly Leu Tyr Leu Asn Ile Trp Ser Pro Ala Ala Asp Gly 
                85                  90                  95      


Lys Lys Arg Pro Val Leu Phe Trp Ile His Gly Gly Ala Phe Leu Phe 
            100                 105                 110         


Gly Ser Gly Ser Phe Pro Trp Tyr Asp Gly Thr Ala Phe Ala Lys His 
        115                 120                 125             


Gly Asp Val Val Val Val Thr Ile Asn Tyr Arg Met Ser Val Phe Gly 
    130                 135                 140                 


Phe Leu Tyr Leu Gly Asp Ala Phe Gly Glu Thr Tyr Ala Gln Ala Gly 
145                 150                 155                 160 


Asn Leu Gly Ile Leu Asp Gln Val Ala Ala Leu Arg Trp Val Lys Glu 
                165                 170                 175     


Asn Ile Glu Ala Phe Gly Gly Asp Pro Asp Asn Ile Thr Ile Phe Gly 
            180                 185                 190         


Glu Ser Ala Gly Ala Ala Ser Val Gly Val Leu Leu Ser Leu Pro Glu 
        195                 200                 205             


Ala Ser Gly Leu Phe Arg Arg Ala Ile Leu Gln Ser Gly Ser Gly Ser 
    210                 215                 220                 


Leu Leu Leu Arg Ser Pro Glu Thr Ala Met Ala Leu Thr Glu Arg Ile 
225                 230                 235                 240 


Leu Glu Arg Ala Gly Ile Arg Pro Gly Asp Arg Asp Arg Leu Leu Ser 
                245                 250                 255     


Ile Pro Ala Ala Glu Leu Leu Gln Ala Ala Met Ser Leu Gly Pro Gly 
            260                 265                 270         


Ile Thr Tyr Gly Pro Val Val Asp Gly His Val Leu Arg Arg His Pro 
        275                 280                 285             


Ile Glu Ala Leu His Asp Gly Ala Ala Ser Asp Ile Pro Ile Leu Ile 
    290                 295                 300                 


Gly Val Thr Lys Asp Glu Tyr Asn Leu Phe Ser Leu Thr Asp Pro Ser 
305                 310                 315                 320 


Leu Thr Arg Leu Glu Glu Lys Glu Leu Leu Asp Arg Met Asn Arg Glu 
                325                 330                 335     


Val Gly Pro Ile Pro Glu Glu Ala Val Arg Tyr Tyr Ala Glu Thr Ala 
            340                 345                 350         


Asp Arg Ser Ala Pro Ala Trp Gln Thr Trp Leu Arg Ile Met Thr Tyr 
        355                 360                 365             


Leu Val Phe Val Asp Gly Met Leu Arg Thr Ala Asp Ala Gln Ala Ala 
    370                 375                 380                 


Gln Gly Ala Asn Val Tyr Met Tyr Arg Phe Asp Tyr Glu Thr Pro Ala 
385                 390                 395                 400 


Phe Gly Gly Gln Leu Lys Ala Cys His Thr Leu Glu Leu Pro Phe Val 
                405                 410                 415     


Phe His Asn Leu His Gln Pro Gly Val Glu Asn Phe Val Gly Asn Arg 
            420                 425                 430         


Pro Glu Arg Glu Ala Ile Ala Ser Glu Met His Gly Ala Trp Leu Ser 
        435                 440                 445             


Phe Ala Arg Thr Gly Asn Pro Asn Gly Ala His Leu Pro Glu Lys Trp 
    450                 455                 460                 


Pro Val Tyr Thr Lys Glu His Lys Pro Val Phe Val Phe Ser Ala Ala 
465                 470                 475                 480 


Ser His Val Glu Asp Asp Pro Phe Gly Arg Glu Arg Glu Ala Trp Gln 
                485                 490                 495     


Gly Arg Leu 
            


<210>  310
<211>  1473
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 303

<400>  310
atggacgtga tcgtcgagac gcgatacggc agggtgatgg ggcgagaaga ggatggggtt     60

cgcgtgtttt taggcgtccc gtacgcgaag gcgccgcagg gcgaacggag attcttgccg    120

ccggagccgg tcgagccatg ggccgacgtg ctggatgcgc gcgcacacgg gcccatctgt    180

ccacaggtgg ccaatccgct gaaccctgtc gacggtttcg tgcagtccga ggattgcctg    240

cggttgaaca tctacgcgcc agccgagggg acgggccacc ctgtgatggt ctggatccac    300

ggcggcgcgt tcgtgtttgg atcgggccag tctccgtggt acgacgggcg cgcgtttgcg    360

agagacggcg tggtgctcgt gagcatcaac taccgcctcg gcccgctcgg ctttctgcac    420

ctcgcccacc tcggcggcga agcctatgcg agctcgggca acgcgggcat tttggaccag    480

gttgccgcgc tcacgtttgt gcgcgacacg attgaggcgt ttgggggcga cccgaaccgg    540

gtgacggtag cgggcgaatc ggccggcgcg tggagcgtcg gcacgctttt ggtgatggaa    600

tcggcgcgag ggttgttcca gcaggccatt ctgcagagcg gcattccgtt tgcgtatcgg    660

acgcccgagt ttgcggagtg gtggaccact cagctgctcg atgcgctcgg catcaaccag    720

gcgtcgtggc atcgcctctt cgacgttccc gccgccgatc tcgtcgcggc cgcagcacgc    780

attcccgcgc gggatgggct gaatctgcgc ccggtcttgg acggcgtgac gctcacgcgg    840

tcattctggg atgcgctgcg agaagggcag gccgcgcacg tgcccaccct cgccggatcg    900

aatcgggagg agctgatgtt gtggatggcc cgcgatcccg agtggcgcac gctttccgac    960

gaggaacgca tcgcgcgcgt ggatcgcatg tgggggccac tcggcgatcg cgcccgagac   1020

tactacgtgg atggccgcac gggcgacgaa ctggaaacgt ggctcgtccg attcgcctcc   1080

atgcggagtt tcacgtatcc gaccatccgc gcggccgaga ttcagagcga atacgccccc   1140

gtctatctgt accggtttga ctacaggccc agtcagctgg gcgcggccca cgcgctcgaa   1200

atcccgttcg tgttcggcac gtatgcccat ccgtcggcgc gggtgctcgt cggagaccgg   1260

ccttcgcatg ccgccgtctc ggacgcgatg cacgcggctt gggtggcgtt cgtccgccat   1320

ggaagcccgc aggcgccgca cctcccggag tggccgacct acgacccgaa gcgccgctcg   1380

accatgattt tcgacgaaac gtctcgcgtc gaggaggatc ccgataccgc cgagcgcgag   1440

ctctggtccg agatgatgag cctgtcgatg tga                                1473


<210>  311
<211>  1473
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 303

<400>  311
atggacgtga tcgtcgagac gcgatacggc aagataatgg ggcgagaaga ggatggggtt     60

cgcgtgtttt taggcgtccc gtacgcgaag gcgccgcagg gcgaacggag attcttgccg    120

ccggagccgg tcgagccatg ggccgacgtg ctggatgcgc gcgcacacgg gcccatctgt    180

ccacaggtgg ccaatccgct gaaccctgtc gacggtttcg tgcagtccga ggattgcctg    240

cggttgaaca tctacgcgcc agccgagggg acgggccacc ctgtgatggt ctggatccac    300

ggcggcgcgt tcgtgtttgg atcgggccag tctccgtggt acgacgggcg cgcgtttgcg    360

agagacggcg tggtgctcgt gagcatcaac taccgcctcg gcccgctcgg ctttctgcac    420

ctcgcccacc tcggcggcga agcctatgcg agctcgggca acgcgggcat tttggaccag    480

gttgccgcgc tcacgtttgt gcgcgacacg attgaggcgt ttgggggcga cccgaaccgg    540

gtgacggtag cgggcgaatc ggccggcgcg tggagcgtcg gcacgctttt ggtgatggaa    600

tcggcgcgag ggttgttcca gcaggccatt ctgcagagcg gcattccgtt tgcgtatcgg    660

acgcccgagt ttgcggagtg gtggaccact cagctgctcg atgcgctcgg catcaaccag    720

gcgtcgtggc atcgcctctt cgacgttccc gccgccgatc tcgtcgcggc cgcagcacgc    780

attcccgcgc gggatgggct gaatctgcgc ccggtcttgg acggcgtgac gctcacgcgg    840

tcattctggg atgcgctgcg agaagggcag gccgcgcacg tgcccaccct cgccggatcg    900

aatcgggagg agctgatgtt gtggatggcc cgcgatcccg agtggcgcac gctttccgac    960

gaggaacgca tcgcgcgcgt ggatcgcatg tgggggccac tcggcgatcg cgcccgagac   1020

tactacgtgg atggccgcac gggcgacgaa ctggaaacgt ggctcgtccg attcgcctcc   1080

atgcggagtt tcacgtatcc gaccatccgc gcggccgaga ttcagagcga atacgccccc   1140

gtctatctgt accggtttga ctacaggccc agtcagctgg gcgcggccca cgcgctcgaa   1200

atcccgttcg tgttcggcac gtatgcccat ccgtcggcgc gggtgctcgt cggagaccgg   1260

ccttcgcatg ccgccgtctc ggacgcgatg cacgcggctt gggtggcgtt cgtccgccat   1320

ggaagcccgc aggcgccgca cctcccggag tggccgacct acgacccgaa gcgccgctcg   1380

accatgattt tcgacgaaac gtctcgcgtc gaggaggatc ccgataccgc cgagcgcgag   1440

ctctggtccg agatgatgag cctgtcgatg tga                                1473


<210>  312
<211>  1473
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 303

<400>  312
atggacgtga tcgtcgagac gcgatacggc aagctgatgg ggcgagaaga ggatggggtt     60

cgcgtgtttt taggcgtccc gtacgcgaag gcgccgcagg gcgaacggag attcttgccg    120

ccggagccgg tcgagccatg ggccgacgtg ctggatgcgc gcgcacacgg gcccatctgt    180

ccacaggtgg ccaatccgct gaaccctgtc gacggtttcg tgcagtccga ggattgcctg    240

cggttgaaca tctacgcgcc agccgagggg acgggccacc ctgtgatggt ctggatccac    300

ggcggcgcgt tcgtgtttgg atcgggccag tctccgtggt acgacgggcg cgcgtttgcg    360

agagacggcg tggtgctcgt gagcatcaac taccgcctcg gcccgctcgg ctttctgcac    420

ctcgcccacc tcggcggcga agcctatgcg agctcgggca acgcgggcat tttggaccag    480

gttgccgcgc tcacgtttgt gcgcgacacg attgaggcgt ttgggggcga cccgaaccgg    540

gtgacggtag cgggcgaatc ggccggcgcg tggagcgtcg gcacgctttt ggtgatggaa    600

tcggcgcgag ggttgttcca gcaggccatt ctgcagagcg gcattccgtt tgcgtatcgg    660

acgcccgagt ttgcggagtg gtggaccact cagctgctcg atgcgctcgg catcaaccag    720

gcgtcgtggc atcgcctctt cgacgttccc gccgccgatc tcgtcgcggc cgcagcacgc    780

attcccgcgc gggatgggct gaatctgcgc ccggtcttgg acggcgtgac gctcacgcgg    840

tcattctggg atgcgctgcg agaagggcag gccgcgcacg tgcccaccct cgccggatcg    900

aatcgggagg agctgatgtt gtggatggcc cgcgatcccg agtggcgcac gctttccgac    960

gaggaacgca tcgcgcgcgt ggatcgcatg tgggggccac tcggcgatcg cgcccgagac   1020

tactacgtgg atggccgcac gggcgacgaa ctggaaacgt ggctcgtccg attcgcctcc   1080

atgcggagtt tcacgtatcc gaccatccgc gcggccgaga ttcagagcga atacgccccc   1140

gtctatctgt accggtttga ctacaggccc agtcagctgg gcgcggccca cgcgctcgaa   1200

atcccgttcg tgttcggcac gtatgcccat ccgtcggcgc gggtgctcgt cggagaccgg   1260

ccttcgcatg ccgccgtctc ggacgcgatg cacgcggctt gggtggcgtt cgtccgccat   1320

ggaagcccgc aggcgccgca cctcccggag tggccgacct acgacccgaa gcgccgctcg   1380

accatgattt tcgacgaaac gtctcgcgtc gaggaggatc ccgataccgc cgagcgcgag   1440

ctctggtccg agatgatgag cctgtcgatg tga                                1473


<210>  313
<211>  1473
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 303

<400>  313
atggacgtga tcgtcgagac gcgatacggc aaggtgatgg ggaaagaaga ggatggggtt     60

cgcgtgtttt taggcgtccc gtacgcgaag gcgccgcagg gcgaacggag attcttgccg    120

ccggagccgg tcgagccatg ggccgacgtg ctggatgcgc gcgcacacgg gcccatctgt    180

ccacaggtgg ccaatccgct gaaccctgtc gacggtttcg tgcagtccga ggattgcctg    240

cggttgaaca tctacgcgcc agccgagggg acgggccacc ctgtgatggt ctggatccac    300

ggcggcgcgt tcgtgtttgg atcgggccag tctccgtggt acgacgggcg cgcgtttgcg    360

agagacggcg tggtgctcgt gagcatcaac taccgcctcg gcccgctcgg ctttctgcac    420

ctcgcccacc tcggcggcga agcctatgcg agctcgggca acgcgggcat tttggaccag    480

gttgccgcgc tcacgtttgt gcgcgacacg attgaggcgt ttgggggcga cccgaaccgg    540

gtgacggtag cgggcgaatc ggccggcgcg tggagcgtcg gcacgctttt ggtgatggaa    600

tcggcgcgag ggttgttcca gcaggccatt ctgcagagcg gcattccgtt tgcgtatcgg    660

acgcccgagt ttgcggagtg gtggaccact cagctgctcg atgcgctcgg catcaaccag    720

gcgtcgtggc atcgcctctt cgacgttccc gccgccgatc tcgtcgcggc cgcagcacgc    780

attcccgcgc gggatgggct gaatctgcgc ccggtcttgg acggcgtgac gctcacgcgg    840

tcattctggg atgcgctgcg agaagggcag gccgcgcacg tgcccaccct cgccggatcg    900

aatcgggagg agctgatgtt gtggatggcc cgcgatcccg agtggcgcac gctttccgac    960

gaggaacgca tcgcgcgcgt ggatcgcatg tgggggccac tcggcgatcg cgcccgagac   1020

tactacgtgg atggccgcac gggcgacgaa ctggaaacgt ggctcgtccg attcgcctcc   1080

atgcggagtt tcacgtatcc gaccatccgc gcggccgaga ttcagagcga atacgccccc   1140

gtctatctgt accggtttga ctacaggccc agtcagctgg gcgcggccca cgcgctcgaa   1200

atcccgttcg tgttcggcac gtatgcccat ccgtcggcgc gggtgctcgt cggagaccgg   1260

ccttcgcatg ccgccgtctc ggacgcgatg cacgcggctt gggtggcgtt cgtccgccat   1320

ggaagcccgc aggcgccgca cctcccggag tggccgacct acgacccgaa gcgccgctcg   1380

accatgattt tcgacgaaac gtctcgcgtc gaggaggatc ccgataccgc cgagcgcgag   1440

ctctggtccg agatgatgag cctgtcgatg tga                                1473


<210>  314
<211>  1473
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 303

<400>  314
atggacgtga tcgtcgagac gcgatacggc aaggtgatgg ggcgagaaga ggaaggggtt     60

cgcgtgtttt taggcgtccc gtacgcgaag gcgccgcagg gcgaacggag attcttgccg    120

ccggagccgg tcgagccatg ggccgacgtg ctggatgcgc gcgcacacgg gcccatctgt    180

ccacaggtgg ccaatccgct gaaccctgtc gacggtttcg tgcagtccga ggattgcctg    240

cggttgaaca tctacgcgcc agccgagggg acgggccacc ctgtgatggt ctggatccac    300

ggcggcgcgt tcgtgtttgg atcgggccag tctccgtggt acgacgggcg cgcgtttgcg    360

agagacggcg tggtgctcgt gagcatcaac taccgcctcg gcccgctcgg ctttctgcac    420

ctcgcccacc tcggcggcga agcctatgcg agctcgggca acgcgggcat tttggaccag    480

gttgccgcgc tcacgtttgt gcgcgacacg attgaggcgt ttgggggcga cccgaaccgg    540

gtgacggtag cgggcgaatc ggccggcgcg tggagcgtcg gcacgctttt ggtgatggaa    600

tcggcgcgag ggttgttcca gcaggccatt ctgcagagcg gcattccgtt tgcgtatcgg    660

acgcccgagt ttgcggagtg gtggaccact cagctgctcg atgcgctcgg catcaaccag    720

gcgtcgtggc atcgcctctt cgacgttccc gccgccgatc tcgtcgcggc cgcagcacgc    780

attcccgcgc gggatgggct gaatctgcgc ccggtcttgg acggcgtgac gctcacgcgg    840

tcattctggg atgcgctgcg agaagggcag gccgcgcacg tgcccaccct cgccggatcg    900

aatcgggagg agctgatgtt gtggatggcc cgcgatcccg agtggcgcac gctttccgac    960

gaggaacgca tcgcgcgcgt ggatcgcatg tgggggccac tcggcgatcg cgcccgagac   1020

tactacgtgg atggccgcac gggcgacgaa ctggaaacgt ggctcgtccg attcgcctcc   1080

atgcggagtt tcacgtatcc gaccatccgc gcggccgaga ttcagagcga atacgccccc   1140

gtctatctgt accggtttga ctacaggccc agtcagctgg gcgcggccca cgcgctcgaa   1200

atcccgttcg tgttcggcac gtatgcccat ccgtcggcgc gggtgctcgt cggagaccgg   1260

ccttcgcatg ccgccgtctc ggacgcgatg cacgcggctt gggtggcgtt cgtccgccat   1320

ggaagcccgc aggcgccgca cctcccggag tggccgacct acgacccgaa gcgccgctcg   1380

accatgattt tcgacgaaac gtctcgcgtc gaggaggatc ccgataccgc cgagcgcgag   1440

ctctggtccg agatgatgag cctgtcgatg tga                                1473


<210>  315
<211>  490
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:304 and encoded by SEQ ID NO:310

<400>  315

Met Asp Val Ile Val Glu Thr Arg Tyr Gly Arg Val Met Gly Arg Glu 
1               5                   10                  15      


Glu Asp Gly Val Arg Val Phe Leu Gly Val Pro Tyr Ala Lys Ala Pro 
            20                  25                  30          


Gln Gly Glu Arg Arg Phe Leu Pro Pro Glu Pro Val Glu Pro Trp Ala 
        35                  40                  45              


Asp Val Leu Asp Ala Arg Ala His Gly Pro Ile Cys Pro Gln Val Ala 
    50                  55                  60                  


Asn Pro Leu Asn Pro Val Asp Gly Phe Val Gln Ser Glu Asp Cys Leu 
65                  70                  75                  80  


Arg Leu Asn Ile Tyr Ala Pro Ala Glu Gly Thr Gly His Pro Val Met 
                85                  90                  95      


Val Trp Ile His Gly Gly Ala Phe Val Phe Gly Ser Gly Gln Ser Pro 
            100                 105                 110         


Trp Tyr Asp Gly Arg Ala Phe Ala Arg Asp Gly Val Val Leu Val Ser 
        115                 120                 125             


Ile Asn Tyr Arg Leu Gly Pro Leu Gly Phe Leu His Leu Ala His Leu 
    130                 135                 140                 


Gly Gly Glu Ala Tyr Ala Ser Ser Gly Asn Ala Gly Ile Leu Asp Gln 
145                 150                 155                 160 


Val Ala Ala Leu Thr Phe Val Arg Asp Thr Ile Glu Ala Phe Gly Gly 
                165                 170                 175     


Asp Pro Asn Arg Val Thr Val Ala Gly Glu Ser Ala Gly Ala Trp Ser 
            180                 185                 190         


Val Gly Thr Leu Leu Val Met Glu Ser Ala Arg Gly Leu Phe Gln Gln 
        195                 200                 205             


Ala Ile Leu Gln Ser Gly Ile Pro Phe Ala Tyr Arg Thr Pro Glu Phe 
    210                 215                 220                 


Ala Glu Trp Trp Thr Thr Gln Leu Leu Asp Ala Leu Gly Ile Asn Gln 
225                 230                 235                 240 


Ala Ser Trp His Arg Leu Phe Asp Val Pro Ala Ala Asp Leu Val Ala 
                245                 250                 255     


Ala Ala Ala Arg Ile Pro Ala Arg Asp Gly Leu Asn Leu Arg Pro Val 
            260                 265                 270         


Leu Asp Gly Val Thr Leu Thr Arg Ser Phe Trp Asp Ala Leu Arg Glu 
        275                 280                 285             


Gly Gln Ala Ala His Val Pro Thr Leu Ala Gly Ser Asn Arg Glu Glu 
    290                 295                 300                 


Leu Met Leu Trp Met Ala Arg Asp Pro Glu Trp Arg Thr Leu Ser Asp 
305                 310                 315                 320 


Glu Glu Arg Ile Ala Arg Val Asp Arg Met Trp Gly Pro Leu Gly Asp 
                325                 330                 335     


Arg Ala Arg Asp Tyr Tyr Val Asp Gly Arg Thr Gly Asp Glu Leu Glu 
            340                 345                 350         


Thr Trp Leu Val Arg Phe Ala Ser Met Arg Ser Phe Thr Tyr Pro Thr 
        355                 360                 365             


Ile Arg Ala Ala Glu Ile Gln Ser Glu Tyr Ala Pro Val Tyr Leu Tyr 
    370                 375                 380                 


Arg Phe Asp Tyr Arg Pro Ser Gln Leu Gly Ala Ala His Ala Leu Glu 
385                 390                 395                 400 


Ile Pro Phe Val Phe Gly Thr Tyr Ala His Pro Ser Ala Arg Val Leu 
                405                 410                 415     


Val Gly Asp Arg Pro Ser His Ala Ala Val Ser Asp Ala Met His Ala 
            420                 425                 430         


Ala Trp Val Ala Phe Val Arg His Gly Ser Pro Gln Ala Pro His Leu 
        435                 440                 445             


Pro Glu Trp Pro Thr Tyr Asp Pro Lys Arg Arg Ser Thr Met Ile Phe 
    450                 455                 460                 


Asp Glu Thr Ser Arg Val Glu Glu Asp Pro Asp Thr Ala Glu Arg Glu 
465                 470                 475                 480 


Leu Trp Ser Glu Met Met Ser Leu Ser Met 
                485                 490 


<210>  316
<211>  490
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:304 and encoded by SEQ ID NO:311

<400>  316

Met Asp Val Ile Val Glu Thr Arg Tyr Gly Lys Ile Met Gly Arg Glu 
1               5                   10                  15      


Glu Asp Gly Val Arg Val Phe Leu Gly Val Pro Tyr Ala Lys Ala Pro 
            20                  25                  30          


Gln Gly Glu Arg Arg Phe Leu Pro Pro Glu Pro Val Glu Pro Trp Ala 
        35                  40                  45              


Asp Val Leu Asp Ala Arg Ala His Gly Pro Ile Cys Pro Gln Val Ala 
    50                  55                  60                  


Asn Pro Leu Asn Pro Val Asp Gly Phe Val Gln Ser Glu Asp Cys Leu 
65                  70                  75                  80  


Arg Leu Asn Ile Tyr Ala Pro Ala Glu Gly Thr Gly His Pro Val Met 
                85                  90                  95      


Val Trp Ile His Gly Gly Ala Phe Val Phe Gly Ser Gly Gln Ser Pro 
            100                 105                 110         


Trp Tyr Asp Gly Arg Ala Phe Ala Arg Asp Gly Val Val Leu Val Ser 
        115                 120                 125             


Ile Asn Tyr Arg Leu Gly Pro Leu Gly Phe Leu His Leu Ala His Leu 
    130                 135                 140                 


Gly Gly Glu Ala Tyr Ala Ser Ser Gly Asn Ala Gly Ile Leu Asp Gln 
145                 150                 155                 160 


Val Ala Ala Leu Thr Phe Val Arg Asp Thr Ile Glu Ala Phe Gly Gly 
                165                 170                 175     


Asp Pro Asn Arg Val Thr Val Ala Gly Glu Ser Ala Gly Ala Trp Ser 
            180                 185                 190         


Val Gly Thr Leu Leu Val Met Glu Ser Ala Arg Gly Leu Phe Gln Gln 
        195                 200                 205             


Ala Ile Leu Gln Ser Gly Ile Pro Phe Ala Tyr Arg Thr Pro Glu Phe 
    210                 215                 220                 


Ala Glu Trp Trp Thr Thr Gln Leu Leu Asp Ala Leu Gly Ile Asn Gln 
225                 230                 235                 240 


Ala Ser Trp His Arg Leu Phe Asp Val Pro Ala Ala Asp Leu Val Ala 
                245                 250                 255     


Ala Ala Ala Arg Ile Pro Ala Arg Asp Gly Leu Asn Leu Arg Pro Val 
            260                 265                 270         


Leu Asp Gly Val Thr Leu Thr Arg Ser Phe Trp Asp Ala Leu Arg Glu 
        275                 280                 285             


Gly Gln Ala Ala His Val Pro Thr Leu Ala Gly Ser Asn Arg Glu Glu 
    290                 295                 300                 


Leu Met Leu Trp Met Ala Arg Asp Pro Glu Trp Arg Thr Leu Ser Asp 
305                 310                 315                 320 


Glu Glu Arg Ile Ala Arg Val Asp Arg Met Trp Gly Pro Leu Gly Asp 
                325                 330                 335     


Arg Ala Arg Asp Tyr Tyr Val Asp Gly Arg Thr Gly Asp Glu Leu Glu 
            340                 345                 350         


Thr Trp Leu Val Arg Phe Ala Ser Met Arg Ser Phe Thr Tyr Pro Thr 
        355                 360                 365             


Ile Arg Ala Ala Glu Ile Gln Ser Glu Tyr Ala Pro Val Tyr Leu Tyr 
    370                 375                 380                 


Arg Phe Asp Tyr Arg Pro Ser Gln Leu Gly Ala Ala His Ala Leu Glu 
385                 390                 395                 400 


Ile Pro Phe Val Phe Gly Thr Tyr Ala His Pro Ser Ala Arg Val Leu 
                405                 410                 415     


Val Gly Asp Arg Pro Ser His Ala Ala Val Ser Asp Ala Met His Ala 
            420                 425                 430         


Ala Trp Val Ala Phe Val Arg His Gly Ser Pro Gln Ala Pro His Leu 
        435                 440                 445             


Pro Glu Trp Pro Thr Tyr Asp Pro Lys Arg Arg Ser Thr Met Ile Phe 
    450                 455                 460                 


Asp Glu Thr Ser Arg Val Glu Glu Asp Pro Asp Thr Ala Glu Arg Glu 
465                 470                 475                 480 


Leu Trp Ser Glu Met Met Ser Leu Ser Met 
                485                 490 


<210>  317
<211>  490
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:304 and encoded by SEQ ID NO:312

<400>  317

Met Asp Val Ile Val Glu Thr Arg Tyr Gly Lys Leu Met Gly Arg Glu 
1               5                   10                  15      


Glu Asp Gly Val Arg Val Phe Leu Gly Val Pro Tyr Ala Lys Ala Pro 
            20                  25                  30          


Gln Gly Glu Arg Arg Phe Leu Pro Pro Glu Pro Val Glu Pro Trp Ala 
        35                  40                  45              


Asp Val Leu Asp Ala Arg Ala His Gly Pro Ile Cys Pro Gln Val Ala 
    50                  55                  60                  


Asn Pro Leu Asn Pro Val Asp Gly Phe Val Gln Ser Glu Asp Cys Leu 
65                  70                  75                  80  


Arg Leu Asn Ile Tyr Ala Pro Ala Glu Gly Thr Gly His Pro Val Met 
                85                  90                  95      


Val Trp Ile His Gly Gly Ala Phe Val Phe Gly Ser Gly Gln Ser Pro 
            100                 105                 110         


Trp Tyr Asp Gly Arg Ala Phe Ala Arg Asp Gly Val Val Leu Val Ser 
        115                 120                 125             


Ile Asn Tyr Arg Leu Gly Pro Leu Gly Phe Leu His Leu Ala His Leu 
    130                 135                 140                 


Gly Gly Glu Ala Tyr Ala Ser Ser Gly Asn Ala Gly Ile Leu Asp Gln 
145                 150                 155                 160 


Val Ala Ala Leu Thr Phe Val Arg Asp Thr Ile Glu Ala Phe Gly Gly 
                165                 170                 175     


Asp Pro Asn Arg Val Thr Val Ala Gly Glu Ser Ala Gly Ala Trp Ser 
            180                 185                 190         


Val Gly Thr Leu Leu Val Met Glu Ser Ala Arg Gly Leu Phe Gln Gln 
        195                 200                 205             


Ala Ile Leu Gln Ser Gly Ile Pro Phe Ala Tyr Arg Thr Pro Glu Phe 
    210                 215                 220                 


Ala Glu Trp Trp Thr Thr Gln Leu Leu Asp Ala Leu Gly Ile Asn Gln 
225                 230                 235                 240 


Ala Ser Trp His Arg Leu Phe Asp Val Pro Ala Ala Asp Leu Val Ala 
                245                 250                 255     


Ala Ala Ala Arg Ile Pro Ala Arg Asp Gly Leu Asn Leu Arg Pro Val 
            260                 265                 270         


Leu Asp Gly Val Thr Leu Thr Arg Ser Phe Trp Asp Ala Leu Arg Glu 
        275                 280                 285             


Gly Gln Ala Ala His Val Pro Thr Leu Ala Gly Ser Asn Arg Glu Glu 
    290                 295                 300                 


Leu Met Leu Trp Met Ala Arg Asp Pro Glu Trp Arg Thr Leu Ser Asp 
305                 310                 315                 320 


Glu Glu Arg Ile Ala Arg Val Asp Arg Met Trp Gly Pro Leu Gly Asp 
                325                 330                 335     


Arg Ala Arg Asp Tyr Tyr Val Asp Gly Arg Thr Gly Asp Glu Leu Glu 
            340                 345                 350         


Thr Trp Leu Val Arg Phe Ala Ser Met Arg Ser Phe Thr Tyr Pro Thr 
        355                 360                 365             


Ile Arg Ala Ala Glu Ile Gln Ser Glu Tyr Ala Pro Val Tyr Leu Tyr 
    370                 375                 380                 


Arg Phe Asp Tyr Arg Pro Ser Gln Leu Gly Ala Ala His Ala Leu Glu 
385                 390                 395                 400 


Ile Pro Phe Val Phe Gly Thr Tyr Ala His Pro Ser Ala Arg Val Leu 
                405                 410                 415     


Val Gly Asp Arg Pro Ser His Ala Ala Val Ser Asp Ala Met His Ala 
            420                 425                 430         


Ala Trp Val Ala Phe Val Arg His Gly Ser Pro Gln Ala Pro His Leu 
        435                 440                 445             


Pro Glu Trp Pro Thr Tyr Asp Pro Lys Arg Arg Ser Thr Met Ile Phe 
    450                 455                 460                 


Asp Glu Thr Ser Arg Val Glu Glu Asp Pro Asp Thr Ala Glu Arg Glu 
465                 470                 475                 480 


Leu Trp Ser Glu Met Met Ser Leu Ser Met 
                485                 490 


<210>  318
<211>  490
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:304 and encoded by SEQ ID NO:313

<400>  318

Met Asp Val Ile Val Glu Thr Arg Tyr Gly Lys Val Met Gly Lys Glu 
1               5                   10                  15      


Glu Asp Gly Val Arg Val Phe Leu Gly Val Pro Tyr Ala Lys Ala Pro 
            20                  25                  30          


Gln Gly Glu Arg Arg Phe Leu Pro Pro Glu Pro Val Glu Pro Trp Ala 
        35                  40                  45              


Asp Val Leu Asp Ala Arg Ala His Gly Pro Ile Cys Pro Gln Val Ala 
    50                  55                  60                  


Asn Pro Leu Asn Pro Val Asp Gly Phe Val Gln Ser Glu Asp Cys Leu 
65                  70                  75                  80  


Arg Leu Asn Ile Tyr Ala Pro Ala Glu Gly Thr Gly His Pro Val Met 
                85                  90                  95      


Val Trp Ile His Gly Gly Ala Phe Val Phe Gly Ser Gly Gln Ser Pro 
            100                 105                 110         


Trp Tyr Asp Gly Arg Ala Phe Ala Arg Asp Gly Val Val Leu Val Ser 
        115                 120                 125             


Ile Asn Tyr Arg Leu Gly Pro Leu Gly Phe Leu His Leu Ala His Leu 
    130                 135                 140                 


Gly Gly Glu Ala Tyr Ala Ser Ser Gly Asn Ala Gly Ile Leu Asp Gln 
145                 150                 155                 160 


Val Ala Ala Leu Thr Phe Val Arg Asp Thr Ile Glu Ala Phe Gly Gly 
                165                 170                 175     


Asp Pro Asn Arg Val Thr Val Ala Gly Glu Ser Ala Gly Ala Trp Ser 
            180                 185                 190         


Val Gly Thr Leu Leu Val Met Glu Ser Ala Arg Gly Leu Phe Gln Gln 
        195                 200                 205             


Ala Ile Leu Gln Ser Gly Ile Pro Phe Ala Tyr Arg Thr Pro Glu Phe 
    210                 215                 220                 


Ala Glu Trp Trp Thr Thr Gln Leu Leu Asp Ala Leu Gly Ile Asn Gln 
225                 230                 235                 240 


Ala Ser Trp His Arg Leu Phe Asp Val Pro Ala Ala Asp Leu Val Ala 
                245                 250                 255     


Ala Ala Ala Arg Ile Pro Ala Arg Asp Gly Leu Asn Leu Arg Pro Val 
            260                 265                 270         


Leu Asp Gly Val Thr Leu Thr Arg Ser Phe Trp Asp Ala Leu Arg Glu 
        275                 280                 285             


Gly Gln Ala Ala His Val Pro Thr Leu Ala Gly Ser Asn Arg Glu Glu 
    290                 295                 300                 


Leu Met Leu Trp Met Ala Arg Asp Pro Glu Trp Arg Thr Leu Ser Asp 
305                 310                 315                 320 


Glu Glu Arg Ile Ala Arg Val Asp Arg Met Trp Gly Pro Leu Gly Asp 
                325                 330                 335     


Arg Ala Arg Asp Tyr Tyr Val Asp Gly Arg Thr Gly Asp Glu Leu Glu 
            340                 345                 350         


Thr Trp Leu Val Arg Phe Ala Ser Met Arg Ser Phe Thr Tyr Pro Thr 
        355                 360                 365             


Ile Arg Ala Ala Glu Ile Gln Ser Glu Tyr Ala Pro Val Tyr Leu Tyr 
    370                 375                 380                 


Arg Phe Asp Tyr Arg Pro Ser Gln Leu Gly Ala Ala His Ala Leu Glu 
385                 390                 395                 400 


Ile Pro Phe Val Phe Gly Thr Tyr Ala His Pro Ser Ala Arg Val Leu 
                405                 410                 415     


Val Gly Asp Arg Pro Ser His Ala Ala Val Ser Asp Ala Met His Ala 
            420                 425                 430         


Ala Trp Val Ala Phe Val Arg His Gly Ser Pro Gln Ala Pro His Leu 
        435                 440                 445             


Pro Glu Trp Pro Thr Tyr Asp Pro Lys Arg Arg Ser Thr Met Ile Phe 
    450                 455                 460                 


Asp Glu Thr Ser Arg Val Glu Glu Asp Pro Asp Thr Ala Glu Arg Glu 
465                 470                 475                 480 


Leu Trp Ser Glu Met Met Ser Leu Ser Met 
                485                 490 


<210>  319
<211>  490
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:304 and encoded by SEQ ID NO:314

<400>  319

Met Asp Val Ile Val Glu Thr Arg Tyr Gly Lys Val Met Gly Arg Glu 
1               5                   10                  15      


Glu Glu Gly Val Arg Val Phe Leu Gly Val Pro Tyr Ala Lys Ala Pro 
            20                  25                  30          


Gln Gly Glu Arg Arg Phe Leu Pro Pro Glu Pro Val Glu Pro Trp Ala 
        35                  40                  45              


Asp Val Leu Asp Ala Arg Ala His Gly Pro Ile Cys Pro Gln Val Ala 
    50                  55                  60                  


Asn Pro Leu Asn Pro Val Asp Gly Phe Val Gln Ser Glu Asp Cys Leu 
65                  70                  75                  80  


Arg Leu Asn Ile Tyr Ala Pro Ala Glu Gly Thr Gly His Pro Val Met 
                85                  90                  95      


Val Trp Ile His Gly Gly Ala Phe Val Phe Gly Ser Gly Gln Ser Pro 
            100                 105                 110         


Trp Tyr Asp Gly Arg Ala Phe Ala Arg Asp Gly Val Val Leu Val Ser 
        115                 120                 125             


Ile Asn Tyr Arg Leu Gly Pro Leu Gly Phe Leu His Leu Ala His Leu 
    130                 135                 140                 


Gly Gly Glu Ala Tyr Ala Ser Ser Gly Asn Ala Gly Ile Leu Asp Gln 
145                 150                 155                 160 


Val Ala Ala Leu Thr Phe Val Arg Asp Thr Ile Glu Ala Phe Gly Gly 
                165                 170                 175     


Asp Pro Asn Arg Val Thr Val Ala Gly Glu Ser Ala Gly Ala Trp Ser 
            180                 185                 190         


Val Gly Thr Leu Leu Val Met Glu Ser Ala Arg Gly Leu Phe Gln Gln 
        195                 200                 205             


Ala Ile Leu Gln Ser Gly Ile Pro Phe Ala Tyr Arg Thr Pro Glu Phe 
    210                 215                 220                 


Ala Glu Trp Trp Thr Thr Gln Leu Leu Asp Ala Leu Gly Ile Asn Gln 
225                 230                 235                 240 


Ala Ser Trp His Arg Leu Phe Asp Val Pro Ala Ala Asp Leu Val Ala 
                245                 250                 255     


Ala Ala Ala Arg Ile Pro Ala Arg Asp Gly Leu Asn Leu Arg Pro Val 
            260                 265                 270         


Leu Asp Gly Val Thr Leu Thr Arg Ser Phe Trp Asp Ala Leu Arg Glu 
        275                 280                 285             


Gly Gln Ala Ala His Val Pro Thr Leu Ala Gly Ser Asn Arg Glu Glu 
    290                 295                 300                 


Leu Met Leu Trp Met Ala Arg Asp Pro Glu Trp Arg Thr Leu Ser Asp 
305                 310                 315                 320 


Glu Glu Arg Ile Ala Arg Val Asp Arg Met Trp Gly Pro Leu Gly Asp 
                325                 330                 335     


Arg Ala Arg Asp Tyr Tyr Val Asp Gly Arg Thr Gly Asp Glu Leu Glu 
            340                 345                 350         


Thr Trp Leu Val Arg Phe Ala Ser Met Arg Ser Phe Thr Tyr Pro Thr 
        355                 360                 365             


Ile Arg Ala Ala Glu Ile Gln Ser Glu Tyr Ala Pro Val Tyr Leu Tyr 
    370                 375                 380                 


Arg Phe Asp Tyr Arg Pro Ser Gln Leu Gly Ala Ala His Ala Leu Glu 
385                 390                 395                 400 


Ile Pro Phe Val Phe Gly Thr Tyr Ala His Pro Ser Ala Arg Val Leu 
                405                 410                 415     


Val Gly Asp Arg Pro Ser His Ala Ala Val Ser Asp Ala Met His Ala 
            420                 425                 430         


Ala Trp Val Ala Phe Val Arg His Gly Ser Pro Gln Ala Pro His Leu 
        435                 440                 445             


Pro Glu Trp Pro Thr Tyr Asp Pro Lys Arg Arg Ser Thr Met Ile Phe 
    450                 455                 460                 


Asp Glu Thr Ser Arg Val Glu Glu Asp Pro Asp Thr Ala Glu Arg Glu 
465                 470                 475                 480 


Leu Trp Ser Glu Met Met Ser Leu Ser Met 
                485                 490 


<210>  320
<211>  3141
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  320
atggaggtaa tgcgagtgga acagaaatat gtcgagagct tctaccctcc ttcggactat     60

cggttgcccc ctcgtgcgtt cttcataccg cactcgacag agcgagaagc gctcgcacgc    120

ggattctacc gtgcgtcgac acaagtgtta ccattagaag gaaagtggaa gtttcgcctg    180

tttgacaatc ctcgcgctgt gccgacggac gtgacttgga tcgatttcga cgactcctca    240

tgggaagaaa tacacgtgcc gtcgaactgg cagatggagg gctatggacg gccacactac    300

acaaacgtga tgtacccctt tcctgttgac ccgccccggg ttccttcgga aaacccgacg    360

ggttgttaca gaaccaaatt ttttctgaca catcacgatg taggcagggt acacttgagg    420

tttgaagggg tcgacggatt gtatcaagtt tacgtgaacg gtcatgatat cggtttcgga    480

tatggtagcc gattgccctc ggaatttgat attacggact ttgttcatgc cggtgacaat    540

gtacttgtcg tggttgtgtg tcagtggtca gctcagtctt atcttgaaga tcaggacatg    600

tggtggttgt ctgggatttt tagagacgta tacattctga agagacctca gatctattta    660

tccgatgttc gggttcgagc actcttgggg actgacggac ggacagggtg tttacatgta    720

gaagtggaga ttgggggaat tttatcacgc gataagcctg ttcccttgag gtttaagctg    780

attgatagca taggggatag tgaaatcctt gaaaacacga tgttgtccga tggattcgcg    840

acttacgagg ccgagatccc taacgtacga ccgtggacag cggaaacgcc caacctgtat    900

acgttgctgg tatcaataga tccggattcc ttgtacgcgg aacatgttgc gttacaagta    960

ggatttagga gaattgagat tgccgatggg cagctgaaga tcaatggagt ccctattgtg   1020

ctcaaaggag taaacaggca tgagcacgac gcccgtctgg gccgagcttt gacgctggat   1080

gtgatgattc gcgatgtgca gatgatgaaa cagaacaaca ttaatgccgt tcgtaccagt   1140

cattaccctc accatcctgt gttctatgat ctgtgtgatc gctacggttt gtatgttcta   1200

gacgaagctg atctcgagtg ccacggcttc gcattgacag ggaactggga ccgattgagt   1260

gacgacccgc agttggaaca ggcgtacgtt gatcgcctgg agcggatgat ctgccgcgac   1320

cgcaatcatg cgtgtgtaat tatgtggtct cttggtaatg agtctgggta tggtcgtaac   1380

catagagcca tggcagaacg ggcaagggcc atagacccga cgagacccgt acactacgaa   1440

ggtgaaacaa ggaggctgct agagcttggt tctgatttac aacacgccgt gatggatgtg   1500

tacagcacaa tgtacacatc cgtcgatgaa ttgagcaggc ttggggaatt ggagcttcct   1560

aaaccacata tattatgtga atttgcccat gcgatgggga acgggccagg tggtcttaag   1620

gagtacgttg agctatttta tcaacagcga aggttgcagg gtgggtttgt atgggagtgg   1680

attgatcacg gaattctggc ctatacatct gatggcagac cgtacttcgc gtacggcggt   1740

gattttggag atgttccgaa cgacttaaat ttcgttattg acggactgtt atttcctgac   1800

cgaactcctt cgccggggct tttcgagtac aagaaagcaa ttgagccggt aagagttctt   1860

gagttcgatc gttcatcagg gatcatcaag gtccagaacc gctatgattt tctctgtctc   1920

gattgcctag tagcggagtg gtcgcttcag gatgaacagt cagtgttggc cggtggcata   1980

cttgaactag agccagtacc acccaggagc attggacaaa taagggtacc atgcgccgaa   2040

atccttaatc ggcacagaga tcggtgcttg actctgactg taagattcct tttgcgccac   2100

ccaaccgact atgcgccagc gttccacgaa gttgcgagtt tttgcgagta tgttgaacgc   2160

agttgccaga atgcaagcat cgacatatat cggccggtta caagatttga aatcgtagaa   2220

aagggtagta gtctatgcat ctatgacgat tcgttctccg ttgagttcga tttgctacgg   2280

gggaggatct ctggggtagg atatcgtggc tcacaaatca ttatgtcacc gctctcaatg   2340

tcgttttgga gagcgcctac agataatgac gatccaccga atcgagaaat gttttcggtt   2400

gccaaagtat ggcgcgatta cggtgtcgat cggctctcag agtccgtgtc aaacatagaa   2460

atcaaaaaac atgacaacgt cgtgcgcgct ctagttgagt cgcgtgtcgc gcctgccggg   2520

ctctcctggg gtatggcgtt gcagtatgag tacattttct tacgcggtgg gttggtcatg   2580

gtacgaattt gcggtaaacc cgaaggagct tatcctccaa ccttgcctcg tataggactg   2640

ttaacgacca ttcacctcga cttcgaatac gtgagttggt ttggacgagg acccggtgag   2700

agttaccgcg attctaagga gtcacaactc attgggagat ataggaggtt ggctgatgaa   2760

ctttataccc cgtatgtgta tccgcaagag aacggtaatc ggacagatgt gtattggatc   2820

tcgattacaa ataaatacat ggagggtctg ttcataacag gcccacaacc tttgaatttt   2880

caagtgagca gattcagtgt ggaggacctc gagcgcgctc ggcatccata tgagttagaa   2940

gaaagtcctt ggagatacct ccgaattgac ttttctcacc atgggcttgg cagcgcgagt   3000

tgtggtcctg gtcctcttcc tgagcatcaa ttgcgtactg agccattcga atggactctg   3060

tgcttcgcac ccctcgcgcg acacgagatc gatgagtcga tcctccatca agtggtcacg   3120

gaaaggttga agttcattta g                                             3141


<210>  321
<211>  1046
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  321

Met Glu Val Met Arg Val Glu Gln Lys Tyr Val Glu Ser Phe Tyr Pro 
1               5                   10                  15      


Pro Ser Asp Tyr Arg Leu Pro Pro Arg Ala Phe Phe Ile Pro His Ser 
            20                  25                  30          


Thr Glu Arg Glu Ala Leu Ala Arg Gly Phe Tyr Arg Ala Ser Thr Gln 
        35                  40                  45              


Val Leu Pro Leu Glu Gly Lys Trp Lys Phe Arg Leu Phe Asp Asn Pro 
    50                  55                  60                  


Arg Ala Val Pro Thr Asp Val Thr Trp Ile Asp Phe Asp Asp Ser Ser 
65                  70                  75                  80  


Trp Glu Glu Ile His Val Pro Ser Asn Trp Gln Met Glu Gly Tyr Gly 
                85                  90                  95      


Arg Pro His Tyr Thr Asn Val Met Tyr Pro Phe Pro Val Asp Pro Pro 
            100                 105                 110         


Arg Val Pro Ser Glu Asn Pro Thr Gly Cys Tyr Arg Thr Lys Phe Phe 
        115                 120                 125             


Leu Thr His His Asp Val Gly Arg Val His Leu Arg Phe Glu Gly Val 
    130                 135                 140                 


Asp Gly Leu Tyr Gln Val Tyr Val Asn Gly His Asp Ile Gly Phe Gly 
145                 150                 155                 160 


Tyr Gly Ser Arg Leu Pro Ser Glu Phe Asp Ile Thr Asp Phe Val His 
                165                 170                 175     


Ala Gly Asp Asn Val Leu Val Val Val Val Cys Gln Trp Ser Ala Gln 
            180                 185                 190         


Ser Tyr Leu Glu Asp Gln Asp Met Trp Trp Leu Ser Gly Ile Phe Arg 
        195                 200                 205             


Asp Val Tyr Ile Leu Lys Arg Pro Gln Ile Tyr Leu Ser Asp Val Arg 
    210                 215                 220                 


Val Arg Ala Leu Leu Gly Thr Asp Gly Arg Thr Gly Cys Leu His Val 
225                 230                 235                 240 


Glu Val Glu Ile Gly Gly Ile Leu Ser Arg Asp Lys Pro Val Pro Leu 
                245                 250                 255     


Arg Phe Lys Leu Ile Asp Ser Ile Gly Asp Ser Glu Ile Leu Glu Asn 
            260                 265                 270         


Thr Met Leu Ser Asp Gly Phe Ala Thr Tyr Glu Ala Glu Ile Pro Asn 
        275                 280                 285             


Val Arg Pro Trp Thr Ala Glu Thr Pro Asn Leu Tyr Thr Leu Leu Val 
    290                 295                 300                 


Ser Ile Asp Pro Asp Ser Leu Tyr Ala Glu His Val Ala Leu Gln Val 
305                 310                 315                 320 


Gly Phe Arg Arg Ile Glu Ile Ala Asp Gly Gln Leu Lys Ile Asn Gly 
                325                 330                 335     


Val Pro Ile Val Leu Lys Gly Val Asn Arg His Glu His Asp Ala Arg 
            340                 345                 350         


Leu Gly Arg Ala Leu Thr Leu Asp Val Met Ile Arg Asp Val Gln Met 
        355                 360                 365             


Met Lys Gln Asn Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro His 
    370                 375                 380                 


His Pro Val Phe Tyr Asp Leu Cys Asp Arg Tyr Gly Leu Tyr Val Leu 
385                 390                 395                 400 


Asp Glu Ala Asp Leu Glu Cys His Gly Phe Ala Leu Thr Gly Asn Trp 
                405                 410                 415     


Asp Arg Leu Ser Asp Asp Pro Gln Leu Glu Gln Ala Tyr Val Asp Arg 
            420                 425                 430         


Leu Glu Arg Met Ile Cys Arg Asp Arg Asn His Ala Cys Val Ile Met 
        435                 440                 445             


Trp Ser Leu Gly Asn Glu Ser Gly Tyr Gly Arg Asn His Arg Ala Met 
    450                 455                 460                 


Ala Glu Arg Ala Arg Ala Ile Asp Pro Thr Arg Pro Val His Tyr Glu 
465                 470                 475                 480 


Gly Glu Thr Arg Arg Leu Leu Glu Leu Gly Ser Asp Leu Gln His Ala 
                485                 490                 495     


Val Met Asp Val Tyr Ser Thr Met Tyr Thr Ser Val Asp Glu Leu Ser 
            500                 505                 510         


Arg Leu Gly Glu Leu Glu Leu Pro Lys Pro His Ile Leu Cys Glu Phe 
        515                 520                 525             


Ala His Ala Met Gly Asn Gly Pro Gly Gly Leu Lys Glu Tyr Val Glu 
    530                 535                 540                 


Leu Phe Tyr Gln Gln Arg Arg Leu Gln Gly Gly Phe Val Trp Glu Trp 
545                 550                 555                 560 


Ile Asp His Gly Ile Leu Ala Tyr Thr Ser Asp Gly Arg Pro Tyr Phe 
                565                 570                 575     


Ala Tyr Gly Gly Asp Phe Gly Asp Val Pro Asn Asp Leu Asn Phe Val 
            580                 585                 590         


Ile Asp Gly Leu Leu Phe Pro Asp Arg Thr Pro Ser Pro Gly Leu Phe 
        595                 600                 605             


Glu Tyr Lys Lys Ala Ile Glu Pro Val Arg Val Leu Glu Phe Asp Arg 
    610                 615                 620                 


Ser Ser Gly Ile Ile Lys Val Gln Asn Arg Tyr Asp Phe Leu Cys Leu 
625                 630                 635                 640 


Asp Cys Leu Val Ala Glu Trp Ser Leu Gln Asp Glu Gln Ser Val Leu 
                645                 650                 655     


Ala Gly Gly Ile Leu Glu Leu Glu Pro Val Pro Pro Arg Ser Ile Gly 
            660                 665                 670         


Gln Ile Arg Val Pro Cys Ala Glu Ile Leu Asn Arg His Arg Asp Arg 
        675                 680                 685             


Cys Leu Thr Leu Thr Val Arg Phe Leu Leu Arg His Pro Thr Asp Tyr 
    690                 695                 700                 


Ala Pro Ala Phe His Glu Val Ala Ser Phe Cys Glu Tyr Val Glu Arg 
705                 710                 715                 720 


Ser Cys Gln Asn Ala Ser Ile Asp Ile Tyr Arg Pro Val Thr Arg Phe 
                725                 730                 735     


Glu Ile Val Glu Lys Gly Ser Ser Leu Cys Ile Tyr Asp Asp Ser Phe 
            740                 745                 750         


Ser Val Glu Phe Asp Leu Leu Arg Gly Arg Ile Ser Gly Val Gly Tyr 
        755                 760                 765             


Arg Gly Ser Gln Ile Ile Met Ser Pro Leu Ser Met Ser Phe Trp Arg 
    770                 775                 780                 


Ala Pro Thr Asp Asn Asp Asp Pro Pro Asn Arg Glu Met Phe Ser Val 
785                 790                 795                 800 


Ala Lys Val Trp Arg Asp Tyr Gly Val Asp Arg Leu Ser Glu Ser Val 
                805                 810                 815     


Ser Asn Ile Glu Ile Lys Lys His Asp Asn Val Val Arg Ala Leu Val 
            820                 825                 830         


Glu Ser Arg Val Ala Pro Ala Gly Leu Ser Trp Gly Met Ala Leu Gln 
        835                 840                 845             


Tyr Glu Tyr Ile Phe Leu Arg Gly Gly Leu Val Met Val Arg Ile Cys 
    850                 855                 860                 


Gly Lys Pro Glu Gly Ala Tyr Pro Pro Thr Leu Pro Arg Ile Gly Leu 
865                 870                 875                 880 


Leu Thr Thr Ile His Leu Asp Phe Glu Tyr Val Ser Trp Phe Gly Arg 
                885                 890                 895     


Gly Pro Gly Glu Ser Tyr Arg Asp Ser Lys Glu Ser Gln Leu Ile Gly 
            900                 905                 910         


Arg Tyr Arg Arg Leu Ala Asp Glu Leu Tyr Thr Pro Tyr Val Tyr Pro 
        915                 920                 925             


Gln Glu Asn Gly Asn Arg Thr Asp Val Tyr Trp Ile Ser Ile Thr Asn 
    930                 935                 940                 


Lys Tyr Met Glu Gly Leu Phe Ile Thr Gly Pro Gln Pro Leu Asn Phe 
945                 950                 955                 960 


Gln Val Ser Arg Phe Ser Val Glu Asp Leu Glu Arg Ala Arg His Pro 
                965                 970                 975     


Tyr Glu Leu Glu Glu Ser Pro Trp Arg Tyr Leu Arg Ile Asp Phe Ser 
            980                 985                 990         


His His Gly Leu Gly Ser Ala Ser  Cys Gly Pro Gly Pro  Leu Pro Glu 
        995                 1000                 1005             


His Gln  Leu Arg Thr Glu Pro  Phe Glu Trp Thr Leu  Cys Phe Ala 
    1010                 1015                 1020             


Pro Leu  Ala Arg His Glu Ile  Asp Glu Ser Ile Leu  His Gln Val 
    1025                 1030                 1035             


Val Thr  Glu Arg Leu Lys Phe  Ile 
    1040                 1045     


<210>  322
<211>  1025
<212>  PRT
<213>  Enterococcus faecalis

<400>  322

Met Lys Thr Trp Glu Asn Tyr Lys Val Asp Ser Ile Asn Arg Leu Pro 
1               5                   10                  15      


Gly Arg Ala His Phe Ser Ser Phe Pro Ser Lys Glu Thr Ala Leu Leu 
            20                  25                  30          


Asn Glu Asn Lys Tyr Thr Gln Ala Tyr Lys Asn Leu Asn Gly Cys Trp 
        35                  40                  45              


His Phe Leu Phe Leu Glu Ala Pro Glu Tyr Ser Pro Glu Asn Phe Phe 
    50                  55                  60                  


Ala Thr Asp Phe Asp Thr Ser Gln Met Asp Gln Ile Thr Val Pro Gly 
65                  70                  75                  80  


Asn Trp Gln Val Gln Gly Tyr Gly Lys Met His Tyr Ser Asp Leu Trp 
                85                  90                  95      


Tyr Asn Phe Pro Ile Asn Pro Pro Tyr Val Pro Thr Glu Asn Pro Thr 
            100                 105                 110         


Gly Ile Tyr Lys Arg Thr Phe Ala Ile Asp Glu Thr Phe His Asp Lys 
        115                 120                 125             


Lys Ile Ile Leu Arg Phe Cys Gly Val Asp Ser Ala Tyr His Val Trp 
    130                 135                 140                 


Val Asn Gly His Glu Val Gly Tyr Ser Lys Gly Ala Arg Asn Glu Ala 
145                 150                 155                 160 


Glu Phe Asp Ile Thr Pro Tyr Ala Lys Ile Gly Glu Thr Asn Asp Leu 
                165                 170                 175     


Thr Val Arg Val Tyr Gln Trp Ser Asp Gly Thr Tyr Leu Glu Asp Gln 
            180                 185                 190         


Asp Met Trp Trp Leu Ser Gly Ile Phe Arg Asp Val Glu Leu Leu Gly 
        195                 200                 205             


Val Pro Glu Asn Gly Leu Glu Asp Phe Phe Ile Ile Ser Asp Leu Asp 
    210                 215                 220                 


Asp Ser Tyr Gln Asn Gly His Leu Ala Ile Thr Gly Lys Phe Trp Gln 
225                 230                 235                 240 


Asp Lys Gly Gln Gln Val Gln Leu Glu Leu Met Asp Gln Gln Gly Lys 
                245                 250                 255     


Thr Val Leu Lys Glu Thr Val Ala Gly Asn Gln Gly Thr Val Glu Phe 
            260                 265                 270         


Ser Ala Ser Leu Pro Ser Val Thr Ala Trp Ser Ala Glu Lys Pro Tyr 
        275                 280                 285             


Leu Tyr Gln Leu Phe Ile Thr Val Phe Ser Glu Gly Glu Val Val Glu 
    290                 295                 300                 


Val Ile Pro Gln Lys Val Gly Phe Arg Asn Ile His Val Ser Gly Glu 
305                 310                 315                 320 


Thr Phe Leu Val Asn Gly Val Ala Ile Lys Leu Lys Gly Met Asn Arg 
                325                 330                 335     


His Asp Tyr Asn Pro Lys Asn Gly Arg Val Val Ser Arg Glu Glu Ile 
            340                 345                 350         


Glu Lys Asp Ile Arg Leu Met Lys Gln Phe Asn Ile Asn Ala Ile Arg 
        355                 360                 365             


Thr Ser His Tyr Pro Ala Ser Ala Tyr Phe Tyr Asp Leu Cys Asp Glu 
    370                 375                 380                 


Tyr Gly Met Tyr Val Ile Asp Glu Thr Asp Leu Glu Cys His Gly Phe 
385                 390                 395                 400 


Glu Leu Thr Gly Glu Tyr Asp Trp Ile Ser Asn Asp Pro Glu Trp Glu 
                405                 410                 415     


Thr Ala Tyr Val Ser Arg Met Val Arg Met Ile Gln Arg Asp Lys Asn 
            420                 425                 430         


His Pro Ser Ile Leu Phe Trp Ser Leu Gly Asn Glu Ser Ala Phe Gly 
        435                 440                 445             


His Asn Phe Ile Glu Met Ala Arg Ile Ala Lys Glu Met Asp Pro Thr 
    450                 455                 460                 


Arg Leu Val His Tyr Glu Gly Asp Phe Glu Ala Glu Val Thr Asp Val 
465                 470                 475                 480 


Tyr Ser Thr Met Tyr Thr Trp Leu Glu His Pro Thr Arg Glu Leu Leu 
                485                 490                 495     


Met Asn Thr Ile Ile Glu Asn Ser Lys Lys Pro His Ile Leu Cys Glu 
            500                 505                 510         


Tyr Cys His Ala Met Gly Asn Gly Pro Gly Asn Leu Lys Glu Tyr Gln 
        515                 520                 525             


Glu Leu Phe Tyr Ala His Asp Lys Leu Gln Gly Gly Phe Ile Trp Glu 
    530                 535                 540                 


Trp Phe Asp His Gly Ile Glu Ser Val Thr Asp Asn Gly Glu Val Tyr 
545                 550                 555                 560 


Tyr Arg Tyr Gly Gly Asp Phe Gly Asp Asp Pro Ser Asn Lys Asp Phe 
                565                 570                 575     


Cys Ile Asp Gly Met Leu Met Pro Asp Arg Thr Pro Ser Pro Ser Leu 
            580                 585                 590         


Tyr Glu Tyr Lys Lys Val Ile Glu Pro Ile Thr Thr Ser Ala Ile Asp 
        595                 600                 605             


Val Leu Ser Gly Glu Phe Ser Leu Leu Ser Arg Phe Asp Phe Glu Asn 
    610                 615                 620                 


Leu Ala Ile Phe Lys Leu Val Tyr Thr Ile Thr Glu Asp Gln Thr Val 
625                 630                 635                 640 


Ile Gln Ser Gly Thr Val Ala Val Pro Ala Ile Ala Ala Arg Ala Glu 
                645                 650                 655     


Gly Arg Leu His Leu Pro Tyr His Leu Asp Phe Pro Lys Lys Ala Gly 
            660                 665                 670         


Ala Ala Tyr Tyr Leu Thr Leu Ser Tyr Gln Leu Lys Glu Thr Thr Ala 
        675                 680                 685             


Tyr Ala Ser Ala Gly His Glu Leu Ala Thr Ala Gln Phe Glu Leu Pro 
    690                 695                 700                 


Ile Ala Thr Pro Gly Ile Glu Ile Thr Pro Val Gly Ser Leu Met Ala 
705                 710                 715                 720 


Lys Glu Ile Gly Pro His Leu Tyr Ile Glu Gly Pro Asn Phe Ser Ile 
                725                 730                 735     


Asn Phe Asp Lys Val Lys Gly Ala Leu Thr Asn Val Thr Arg Asp Gly 
            740                 745                 750         


Lys Lys Leu Leu His Lys Gly Pro Lys Phe Thr Phe Trp Arg Ala Pro 
        755                 760                 765             


Ile Ser Asn Asp Met Glu Ile Ile Asp Glu Met Lys Lys Lys Tyr Phe 
    770                 775                 780                 


Leu His Leu Glu His Glu Ile Val Arg Ser Phe Glu Trp Lys Lys Val 
785                 790                 795                 800 


Asp Asp Phe Ile Gln Val Ile Val Lys Thr Ile Asn Gly Thr Thr Asn 
                805                 810                 815     


Ser Ala Trp His Tyr Gln Cys Thr Tyr Gln Tyr Leu Ile Ala Pro Asn 
            820                 825                 830         


Gly Glu Ile Phe Phe Asp Leu Lys Gly Ser Pro Ala Gly Lys Ile Glu 
        835                 840                 845             


Asn Ala Pro Asp Met Leu Pro Arg Leu Gly Val Thr Leu His Leu Asp 
    850                 855                 860                 


Lys Ser Leu Ser Glu Val Lys Tyr Phe Gly Lys Gly Pro Arg Glu Asn 
865                 870                 875                 880 


Tyr Val Asp Ser Gln Glu Ala Gly Leu Leu Gly Val Tyr Asp Ala Thr 
                885                 890                 895     


Val Ala Glu Met Phe Thr Asn Tyr Val Val Pro Gln Ala Asn Gly Asn 
            900                 905                 910         


His Met Ala Thr Lys Trp Ser Ala Phe Thr Asp Asp Arg Gly Gln Gly 
        915                 920                 925             


Val Val Ala Thr Ala Ala Asp Ser Tyr Asn Phe Ser Val Ser Tyr Phe 
    930                 935                 940                 


Glu Glu Gln Ala Leu Asp Val Ala Lys His Thr Asn Glu Leu Gln Glu 
945                 950                 955                 960 


Ser Glu Tyr Val Val Leu Asn Ile Asp Tyr Lys Gln Asn Ala Leu Gly 
                965                 970                 975     


Ser Tyr Ser Cys Gly Gln Trp Gln Leu Glu Lys Tyr Arg Thr Thr Phe 
            980                 985                 990         


Glu Glu Phe Gln Leu Ala Phe Arg  Leu Thr Pro Phe Asn  Asn Lys Glu 
        995                 1000                 1005             


Ile Gln  Ala Ala Asp Val Ala  His Glu Arg Val Lys  Arg Pro Thr 
    1010                 1015                 1020             


Ile Ser  
    1025 


<210>  323
<211>  992
<212>  PRT
<213>  Lactobacillus casei

<400>  323

Met Thr Thr Ala Lys Leu Trp Glu Lys Pro Glu Leu Thr Asp Ile Asn 
1               5                   10                  15      


Arg Met Ala Pro Arg Ser His Phe Gln Thr Phe Phe Pro Gly Glu Asn 
            20                  25                  30          


Arg Gln Pro Arg His Tyr Gln Leu Leu Asn Gly Thr Trp Gln Phe Lys 
        35                  40                  45              


Phe Leu Asp Ala Pro Glu Tyr Ala Pro Glu Asp Phe Met Ala Val Asp 
    50                  55                  60                  


Phe Asn Asp Gln Asp Trp Asp Gln Ile Pro Val Pro Ser Asn Trp Gln 
65                  70                  75                  80  


Leu Gln Gly Tyr Gly Lys Met His Tyr Ser Asp Leu Trp Tyr Asn Phe 
                85                  90                  95      


Pro Ile Asn Pro Pro Phe Val Pro Ser Glu Asn Pro Thr Gly Leu Tyr 
            100                 105                 110         


Arg Arg Thr Phe Thr Val Asp Glu Val Ala Val Asn Glu Gln Tyr Ile 
        115                 120                 125             


Ile Gly Phe Asp Gly Ala Asp Ser Ala Phe Lys Leu Tyr Leu Asn Gly 
    130                 135                 140                 


Asp Phe Ile Gly Cys Ser Lys Gly Ala Arg Leu Pro Ser Glu Phe Asp 
145                 150                 155                 160 


Val Thr Lys Ala Leu Lys Gln Gly Thr Asn Thr Ile Ala Val Glu Val 
                165                 170                 175     


Val Gln Trp Ser Asp Gly Thr Tyr Leu Glu Asp Gln Asp Met Trp Trp 
            180                 185                 190         


Leu Ser Gly Leu Phe Arg Asp Val Ser Leu Tyr Ser Arg Pro Gln Asn 
        195                 200                 205             


Gly Leu Tyr Asp Val Arg Val Arg Thr Tyr Leu Leu Lys Asp Tyr Arg 
    210                 215                 220                 


Ala Gly Glu Leu Val Val Thr Pro Thr Leu Ser Gly Ala Val Pro Ser 
225                 230                 235                 240 


Lys Ile His Tyr Glu Leu Thr Lys Asp Gly Ala Thr Leu Ile Asp Gln 
                245                 250                 255     


Thr Leu Ser Thr Asp Val Ser Leu Asp Val Thr Leu Asn Asp Ile Gln 
            260                 265                 270         


Ala Trp Ser Ala Glu Ala Pro Asn Leu Tyr Asp Leu Thr Met Thr Val 
        275                 280                 285             


Leu Gln Asn Asp Ala Pro Leu Glu Val Val Arg Gln Arg Ile Gly Phe 
    290                 295                 300                 


Arg Gln Ile Glu Leu Asn Gly Lys Thr Phe Leu Val Asn Gly Lys Ala 
305                 310                 315                 320 


Ile Lys Phe Lys Gly Val Asn Met His Asp Tyr Ser Ala Thr Glu Gly 
                325                 330                 335     


Arg Val Met Ser Glu Ala Asp Phe Lys Lys Asn Ile Ile Ser Met Lys 
            340                 345                 350         


Arg Asn Asn Ile Asn Ala Ile Arg Thr Ala His Tyr Pro Lys Ala Pro 
        355                 360                 365             


Tyr Phe Tyr Asp Leu Cys Asp Glu Leu Gly Met Tyr Val Ile Asp Glu 
    370                 375                 380                 


Thr Asp Leu Glu Cys His Gly Phe Glu Leu Thr Glu Arg Tyr Asp Trp 
385                 390                 395                 400 


Ile Thr Asp Asp Pro Arg Trp Lys Thr Ala Tyr Val Asp Arg Met Arg 
                405                 410                 415     


Arg Thr Leu Gln Arg Asp Lys Asn His Pro Ala Ile Ile Met Trp Ser 
            420                 425                 430         


Leu Gly Asn Glu Ser Asp Phe Gly Asp Asn Phe Arg Ala Met Ala Ala 
        435                 440                 445             


Tyr Cys Lys Ala Glu Asp Pro Thr Arg Leu Val His Tyr Glu Gly Asp 
    450                 455                 460                 


Phe Glu Ala Glu Val Ser Asp Val Tyr Ser Thr Met Tyr Thr Trp Leu 
465                 470                 475                 480 


Glu His Asp Thr Lys Met Thr Met Ala Asp Val Leu Gln Lys Thr Gln 
                485                 490                 495     


Lys Pro His Ile Leu Cys Glu Tyr Ala His Ser Met Gly Asn Gly Pro 
            500                 505                 510         


Gly Asn Leu Lys Glu Tyr Gln Asp Leu Phe Tyr Gly His Gln Gln Leu 
        515                 520                 525             


Gln Gly Gly Phe Ile Trp Glu Trp Phe Asp Gln Gly Val Ala Ala Gln 
    530                 535                 540                 


Gln Gly Asp Gln Thr Tyr Tyr Arg Tyr Gly Gly Asp Phe Gly Asp Gln 
545                 550                 555                 560 


Pro Asn Asn Ser Asn Phe Cys Ile Asp Gly Leu Ile Arg Pro Asp Gly 
                565                 570                 575     


Gln Pro Ser Thr Ala Leu Thr Glu Val Lys Lys Thr Phe Glu Pro Phe 
            580                 585                 590         


Gln Met Thr Val Arg Asp Leu Pro Thr Gln Thr Ile Thr Val Thr Asn 
        595                 600                 605             


Arg Leu Asp Phe Leu Ser Ser Asp Gln Phe Asn Phe Gly Tyr Glu Leu 
    610                 615                 620                 


Glu Ala Asp Gly Lys Leu Met Ala Thr Gly Lys Ile Asp Leu Pro Thr 
625                 630                 635                 640 


Ile Met Ala Gly Thr Thr Lys Thr Ile Lys Leu Asp Ile Glu Leu Pro 
                645                 650                 655     


Lys Leu Asp Pro Glu Val Ile Tyr Asn Leu His Val Leu Thr Glu Leu 
            660                 665                 670         


Lys Asn Gln Thr Ser Trp Ala Asp Ala Gly Thr Val Leu Ser Gln Thr 
        675                 680                 685             


Val Val Asn Leu Gln Arg Pro Gln His His Met Thr His Gln Gln Thr 
    690                 695                 700                 


Thr Ala Leu Gln Ala Ser Glu Asn Ala Thr Thr Ile Met Val Thr Gly 
705                 710                 715                 720 


Gly Gln Asn Glu Tyr Arg Phe Asp Lys Ile Lys Gly Thr Phe Ser Leu 
                725                 730                 735     


Thr His Asp Gly His Lys Leu Ile Ala Asp Gly Ile Lys Met Asn Phe 
            740                 745                 750         


Trp Arg Ala Pro Ile Asp Asn Asp Met Tyr Leu Leu Asp Asp Tyr Tyr 
        755                 760                 765             


Asn Lys Tyr Phe Leu Asn Leu Trp His Glu Ser Thr Arg Glu Val Gln 
    770                 775                 780                 


Leu His Pro Gln Thr Asn Gly Asp Tyr Val Val Asn Leu Thr Lys Gln 
785                 790                 795                 800 


Val Gly Thr Thr Asn Ser Gly Trp Tyr Tyr Leu Ile Gln Gln Gln Tyr 
                805                 810                 815     


Thr Met His Gln Asp Gly Ser Phe Asp Leu Asp Val Ile Gly Lys Ala 
            820                 825                 830         


Ser Gly Lys Arg Asp Met Ala Pro Glu Met Leu Pro Arg Ile Gly Val 
        835                 840                 845             


Lys Met Thr Leu Pro Lys Ala Tyr Gln Gln Val Ser Tyr Asp Gly Leu 
    850                 855                 860                 


Gly Pro Thr Glu Asn Tyr Ser Asp Ser His Gln Ala Ala Tyr Tyr Ser 
865                 870                 875                 880 


His Phe Thr Ser Ser Val Asp Asp Leu Phe Val Asn Tyr Val Lys Pro 
                885                 890                 895     


Gln Glu Asn Gly Asn His Met Asp Thr Asp Gln Ile Ala Leu Thr Asp 
            900                 905                 910         


Gly Gln Asp Gln Leu Thr Val Thr Met Ala Lys Pro Leu Asn Phe Ser 
        915                 920                 925             


Val Ser Asn Tyr Ala Asp Glu Thr Leu Glu Ala Ala Lys His Thr Ile 
    930                 935                 940                 


Asp Leu Lys Lys Ser Asp Ala Leu Asn Leu Tyr Leu Asp Phe Arg Gln 
945                 950                 955                 960 


Asn Gly Leu Gly Thr Asn Ser Cys Gly Gln Asn Gln Leu Lys Arg His 
                965                 970                 975     


Arg Cys Lys Phe Asp Asp Phe Glu Leu Gly Phe Asn Phe Lys Val Asn 
            980                 985                 990         


<210>  324
<211>  1023
<212>  PRT
<213>  Aspergillus nidulans 

<400>  324

Met Ala Ser Leu Ser Ala Val Ser Gly Trp Pro Thr Tyr Leu Pro Asp 
1               5                   10                  15      


Trp Ser Asn Leu Asn Val Leu His Arg Asn Thr Leu Pro Pro Arg Ala 
            20                  25                  30          


His Phe Tyr Ser Tyr Pro Asn Glu Glu Ala Ala Leu Thr Phe Asn Arg 
        35                  40                  45              


Asp Glu Gly Leu Phe Gln Ser Leu Asn Gly Thr Trp Lys Phe His Tyr 
    50                  55                  60                  


Asp Ala Ser Pro Phe Glu Ala Pro Ile Trp Asn Thr Ala Asn Thr Thr 
65                  70                  75                  80  


Glu Trp Asp Asp Ile Ile Val Pro Gly Val Trp Gln Met Gln Gly Tyr 
                85                  90                  95      


Gly Arg Pro Gln Tyr Thr Asn Ile His Tyr Pro Ile Pro Val Thr Pro 
            100                 105                 110         


Pro Asn Val Ser Tyr Met Asn Pro Thr Gly Ser Tyr Trp Arg Glu Phe 
        115                 120                 125             


Asp Val Pro Ala Asp Trp Asp Gly Gln Gln Ile Arg Leu Arg Tyr Glu 
    130                 135                 140                 


Gly Val Asp Ser Ala Phe His Val Trp Val Asn Gly Glu Glu Val Gly 
145                 150                 155                 160 


Tyr Ser Gln Gly Ser Arg Asn Pro Ser Glu Phe Asp Ile Thr Gly Tyr 
                165                 170                 175     


Leu Ser Ser Glu Gly Thr Asn Thr Leu Ala Thr Arg Val Tyr Gln Trp 
            180                 185                 190         


Ser Asp Gly Thr Tyr Leu Glu Asp Gln Asp Gln Trp Trp Leu Ser Gly 
        195                 200                 205             


Ile Phe Arg Asp Val Tyr Leu Val Pro Phe Pro Ser Ser Ala Ile Thr 
    210                 215                 220                 


Asp Phe Phe Ile Gln Pro Glu Val Asp Asp Gly Phe Ala Ser Gly Thr 
225                 230                 235                 240 


Leu Lys Val Asn Val Thr Ile Gln Gly Glu His Gly Asn Leu Ser Val 
                245                 250                 255     


Lys Val Leu Ser Pro Gly Gly Asn Val Val Asp Glu Trp Thr Gly Ser 
            260                 265                 270         


Ser Ser Thr Ile Tyr Ser Lys Asp Ile Lys Gly Asp Asp Phe Leu Leu 
        275                 280                 285             


Trp Ser Ala Glu Thr Pro Asn Leu Tyr Thr Val Leu Ile Glu Phe Asn 
    290                 295                 300                 


Gly Arg Thr Ile Ser Gln Lys Val Gly Phe Arg Arg Val Glu Met Ser 
305                 310                 315                 320 


Gly Ser Asn Phe Leu Val Asn Gly Gln Pro Ile Ile Ile Tyr Gly Val 
                325                 330                 335     


Asn Arg His Glu His Asn Tyr Thr Ser Gly Arg Thr Val Pro Tyr Glu 
            340                 345                 350         


Ser Met Arg Ala Asp Leu Ile Arg Met Lys Gln Ser Asn Ile Asn Ala 
        355                 360                 365             


Ile Arg Thr Ala His Tyr Pro Gln His Pro Ser Phe Tyr Asp Val Ala 
    370                 375                 380                 


Asp Glu Leu Gly Phe Tyr Val Ile Thr Glu Ala Asp Leu Glu Cys His 
385                 390                 395                 400 


Gly Phe Arg Asp Ile Ala Gly Ser Glu Glu Asn Ala Ala Ala Trp Thr 
                405                 410                 415     


Ser Asp Asn Pro Glu Trp Thr His Ala Tyr Leu Asp Arg Ala Glu Gln 
            420                 425                 430         


Leu Val Glu Arg Tyr Lys Asn His Pro Ser Val Ile Met Trp Ser Leu 
        435                 440                 445             


Gly Asn Glu Cys Gln Tyr Gly Gln Asn Gln Ala Ala Met Tyr Lys Trp 
    450                 455                 460                 


Ile Lys Glu Arg Asp Pro Ser Arg Leu Val His Tyr Glu Gln Asp His 
465                 470                 475                 480 


Asn Ala Glu Thr Ala Asp Ile Tyr Ser Gln Met Tyr Ser Ser Pro Asp 
                485                 490                 495     


Thr Met Leu Glu His Met Ala Asn His Thr Asp Lys Pro Leu Ile Leu 
            500                 505                 510         


Cys Glu Phe Ala His Ala Met Gly Asn Gly Pro Gly Gly Leu Lys Glu 
        515                 520                 525             


Tyr Ile Glu Leu Phe Arg Ser His Pro Leu Ser Gln Gly Gly Leu Val 
    530                 535                 540                 


Trp Glu Phe Asn Asn His Gly Leu Leu Lys Lys Glu Gly Asp Leu Glu 
545                 550                 555                 560 


Tyr Tyr Ala Tyr Gly Gly Asp Phe Gly Asp Glu Pro Asn Asp Ala Asp 
                565                 570                 575     


Phe Val Met Asp Gly Leu Thr Leu Ser Asp His Thr Pro Met Pro Ser 
            580                 585                 590         


Leu Leu Glu Tyr Ala Lys Ile Ile Gln Pro Val Ser Val Asn Leu Thr 
        595                 600                 605             


Asp Asp Ser Ser Ser Met Val Ile Thr Asn His Tyr Ala Phe Val Asp 
    610                 615                 620                 


Leu Ser Gly Leu Asp Val Ser Trp His Ile Val Gln Asp Gly Glu Thr 
625                 630                 635                 640 


Thr Glu Ala Gln Glu Leu Asp Leu Pro Pro Val Pro Ala Gly Glu Ser 
                645                 650                 655     


Arg Thr Val Asp Leu Pro Leu Asp Pro Ser Ser Leu Ser Lys Glu Thr 
            660                 665                 670         


Trp Leu Thr Ile Glu Phe Lys Leu Lys Glu Asp Lys Ala Trp Ala Val 
        675                 680                 685             


Arg Gly His Val Val Ala Trp Asp Gln Leu Tyr Phe Pro Gly Ser Ser 
    690                 695                 700                 


Ala Ser Thr Ser Ser Ser Lys Arg Ser Thr Pro Ile Ser Arg Gln Thr 
705                 710                 715                 720 


Ser Gly Gly Leu Glu Val Lys Gln Asn Gln Thr Ser Leu Arg Ile Ile 
                725                 730                 735     


Thr Gly Thr Ser Ile Phe Gly Phe Asn Leu Ile Gln Gly Asn Val Thr 
            740                 745                 750         


Trp Glu Ala Asn Gly Ala Ser Leu Phe Gln Arg Gly Pro Glu Leu Ser 
        755                 760                 765             


Phe Ile Arg Ala Met Thr Gln Asn Asp Glu Gly Gln Ser Gly Asn Glu 
    770                 775                 780                 


Ala Glu Trp Asp Asp Ala Trp Val Gly Thr Met His Thr Gln Val Arg 
785                 790                 795                 800 


Asp Val Thr Trp Arg Ser Ser Asp Thr Glu Ala Ile Val His Phe Lys 
                805                 810                 815     


Val Arg Val Ala Pro Gln Val Leu Glu Trp Gly Val Glu Ala Asp Leu 
            820                 825                 830         


Ile Tyr Thr Ile Ser Thr Glu Asp Ser Val Pro Thr Leu His Ile His 
        835                 840                 845             


Ala Thr Gly Glu Phe Val Gly Thr Asn Thr Pro Ser Val Val Pro Arg 
    850                 855                 860                 


Ile Gly Leu Gln Thr Ile Leu Pro Ser Ser Phe Asn Phe Val Arg Trp 
865                 870                 875                 880 


Leu Gly Arg Gly Pro Gly Glu Asn Tyr Lys Asp Ser Lys Gln Ala Cys 
                885                 890                 895     


Arg Ile Gly Glu Tyr Ser Ala Thr Val Glu Glu Leu Phe Thr His Tyr 
            900                 905                 910         


Asp Tyr Pro Gln Glu Asn Gly Asn Arg Glu Asp Leu Arg Trp Leu Gln 
        915                 920                 925             


Ile Ser Asp Pro Gly Thr Gly Val Thr Leu Asp Ala Arg Arg Ala Asp 
    930                 935                 940                 


Ala Ser Thr Asn Gln Thr Ala Val Glu Val Phe Ser Phe Thr Ala Ser 
945                 950                 955                 960 


Gln Tyr Met Pro Ile Asp Leu Asn Asn Ala Lys His Pro Phe Asp Leu 
                965                 970                 975     


Lys Pro Leu Asp Met Thr Ile Leu Trp Leu Asp Tyr Asp Asn His Gly 
            980                 985                 990         


Leu Gly Ser Ala Ser Val Gly Pro  Gln Pro Phe Glu Gln  Tyr Arg Cys 
        995                 1000                 1005             


Lys Thr  Glu Pro Phe Asp Phe  Ala Phe Glu Leu Ser  Leu Leu Ser 
    1010                 1015                 1020             


<210>  325
<211>  1030
<212>  PRT
<213>  Escherichia coli

<400>  325

Met Asn Arg Trp Glu Asn Ile Gln Leu Thr His Glu Asn Arg Leu Ala 
1               5                   10                  15      


Pro Arg Ala Tyr Phe Phe Ser Tyr Asp Ser Val Ala Gln Ala Arg Thr 
            20                  25                  30          


Phe Ala Arg Glu Thr Ser Ser Leu Phe Leu Pro Leu Ser Gly Gln Trp 
        35                  40                  45              


Asn Phe His Phe Phe Asp His Pro Leu Gln Val Pro Glu Ala Phe Thr 
    50                  55                  60                  


Ser Glu Leu Met Ala Asp Trp Gly His Ile Thr Val Pro Ala Met Trp 
65                  70                  75                  80  


Gln Met Glu Gly His Gly Lys Leu Gln Tyr Thr Asp Glu Gly Phe Pro 
                85                  90                  95      


Phe Pro Ile Asp Val Pro Phe Val Pro Ser Asp Asn Pro Thr Gly Ala 
            100                 105                 110         


Tyr Gln Arg Ile Phe Thr Leu Ser Asp Gly Trp Gln Gly Lys Gln Thr 
        115                 120                 125             


Leu Ile Lys Phe Asp Gly Val Glu Thr Tyr Phe Glu Val Tyr Val Asn 
    130                 135                 140                 


Gly Gln Tyr Val Gly Phe Ser Lys Gly Ser Arg Leu Thr Ala Glu Phe 
145                 150                 155                 160 


Asp Ile Ser Ala Met Val Lys Thr Gly Asp Asn Leu Leu Cys Val Arg 
                165                 170                 175     


Val Met Gln Trp Ala Asp Ser Thr Tyr Val Glu Asp Gln Asp Met Trp 
            180                 185                 190         


Trp Ser Ala Gly Ile Phe Arg Asp Val Tyr Leu Val Gly Lys His Leu 
        195                 200                 205             


Thr His Ile Asn Asp Phe Thr Val Arg Thr Asp Phe Asp Glu Ala Tyr 
    210                 215                 220                 


Cys Asp Ala Thr Leu Ser Cys Glu Val Val Leu Glu Asn Leu Ala Ala 
225                 230                 235                 240 


Ser Pro Val Val Thr Thr Leu Glu Tyr Thr Leu Phe Asp Gly Glu Arg 
                245                 250                 255     


Val Val His Ser Ser Ala Ile Asp His Leu Ala Ile Glu Lys Leu Thr 
            260                 265                 270         


Ser Ala Ser Phe Ala Phe Thr Val Glu Gln Pro Gln Gln Trp Ser Ala 
        275                 280                 285             


Glu Ser Pro Tyr Leu Tyr His Leu Val Met Thr Leu Lys Asp Ala Asn 
    290                 295                 300                 


Gly Asn Val Leu Glu Val Val Pro Gln Arg Val Gly Phe Arg Asp Ile 
305                 310                 315                 320 


Lys Val Arg Asp Gly Leu Phe Trp Ile Asn Asn Arg Tyr Val Met Leu 
                325                 330                 335     


His Gly Val Asn Arg His Asp Asn Asp His Arg Lys Gly Arg Ala Val 
            340                 345                 350         


Gly Met Asp Arg Val Glu Lys Asp Leu Gln Leu Met Lys Gln His Asn 
        355                 360                 365             


Ile Asn Ser Val Arg Thr Ala His Tyr Pro Asn Asp Pro Arg Phe Tyr 
    370                 375                 380                 


Glu Leu Cys Asp Ile Tyr Gly Leu Phe Val Met Ala Glu Thr Asp Val 
385                 390                 395                 400 


Glu Ser His Gly Phe Ala Asn Val Gly Asp Ile Ser Arg Ile Thr Asp 
                405                 410                 415     


Asp Pro Gln Trp Glu Lys Val Tyr Val Glu Arg Ile Val Arg His Ile 
            420                 425                 430         


His Ala Gln Lys Asn His Pro Ser Ile Ile Ile Trp Ser Leu Gly Asn 
        435                 440                 445             


Glu Ser Gly Tyr Gly Cys Asn Ile Arg Ala Met Tyr His Ala Ala Lys 
    450                 455                 460                 


Ala Leu Asp Asp Thr Arg Leu Val His Tyr Glu Glu Asp Arg Asp Ala 
465                 470                 475                 480 


Glu Val Val Asp Ile Ile Ser Thr Met Tyr Thr Arg Val Pro Leu Met 
                485                 490                 495     


Asn Glu Phe Gly Glu Tyr Pro His Pro Lys Pro Arg Ile Ile Cys Glu 
            500                 505                 510         


Tyr Ala His Ala Met Gly Asn Gly Pro Gly Gly Leu Thr Glu Tyr Gln 
        515                 520                 525             


Asn Val Phe Tyr Lys His Asp Cys Ile Gln Gly His Tyr Val Trp Glu 
    530                 535                 540                 


Trp Cys Asp His Gly Ile Gln Ala Gln Asp Asp His Gly Asn Val Trp 
545                 550                 555                 560 


Tyr Lys Phe Gly Gly Asp Tyr Gly Asp Tyr Pro Asn Asn Tyr Asn Phe 
                565                 570                 575     


Cys Leu Asp Gly Leu Ile Tyr Ser Asp Gln Thr Pro Gly Pro Gly Leu 
            580                 585                 590         


Lys Glu Tyr Lys Gln Val Ile Ala Pro Val Lys Ile His Ala Arg Asp 
        595                 600                 605             


Leu Thr Arg Gly Glu Leu Lys Val Glu Asn Lys Leu Trp Phe Thr Thr 
    610                 615                 620                 


Leu Asp Asp Tyr Thr Leu His Ala Glu Val Arg Ala Glu Gly Glu Thr 
625                 630                 635                 640 


Leu Ala Thr Gln Gln Ile Lys Leu Arg Asp Val Ala Pro Asn Ser Glu 
                645                 650                 655     


Ala Pro Leu Gln Ile Thr Leu Pro Gln Leu Asp Ala Arg Glu Ala Phe 
            660                 665                 670         


Leu Asn Ile Thr Val Thr Lys Asp Ser Arg Thr Arg Tyr Ser Glu Ala 
        675                 680                 685             


Gly His Pro Ile Ala Thr Tyr Gln Phe Pro Leu Lys Glu Asn Thr Ala 
    690                 695                 700                 


Gln Pro Val Pro Phe Ala Pro Asn Asn Ala Arg Pro Leu Thr Leu Glu 
705                 710                 715                 720 


Asp Asp Arg Leu Ser Cys Thr Val Arg Gly Tyr Asn Phe Ala Ile Thr 
                725                 730                 735     


Phe Ser Lys Met Ser Gly Lys Pro Thr Ser Trp Gln Val Asn Gly Glu 
            740                 745                 750         


Ser Leu Leu Thr Arg Glu Pro Lys Ile Asn Phe Phe Lys Pro Met Ile 
        755                 760                 765             


Asp Asn His Lys Gln Glu Tyr Glu Gly Leu Trp Gln Pro Asn His Leu 
    770                 775                 780                 


Gln Ile Met Gln Glu His Leu Arg Asp Phe Ala Val Glu Gln Ser Asp 
785                 790                 795                 800 


Gly Glu Val Leu Ile Ile Ser Arg Thr Val Ile Ala Pro Pro Val Phe 
                805                 810                 815     


Asp Phe Gly Met Arg Cys Thr Tyr Ile Trp Arg Ile Ala Ala Asp Gly 
            820                 825                 830         


Gln Val Asn Val Ala Leu Ser Gly Glu Arg Tyr Gly Asp Tyr Pro His 
        835                 840                 845             


Ile Ile Pro Cys Ile Gly Phe Thr Met Gly Ile Asn Gly Glu Tyr Asp 
    850                 855                 860                 


Gln Val Ala Tyr Tyr Gly Arg Gly Pro Gly Glu Asn Tyr Ala Asp Ser 
865                 870                 875                 880 


Gln Gln Ala Asn Ile Ile Asp Ile Trp Arg Ser Thr Val Asp Ala Met 
                885                 890                 895     


Phe Glu Asn Tyr Pro Phe Pro Gln Asn Asn Gly Asn Arg Gln His Val 
            900                 905                 910         


Arg Trp Thr Ala Leu Thr Asn Arg His Gly Asn Gly Leu Leu Val Val 
        915                 920                 925             


Pro Gln Arg Pro Ile Asn Phe Ser Ala Trp His Tyr Thr Gln Glu Asn 
    930                 935                 940                 


Ile His Ala Ala Gln His Cys Asn Glu Leu Gln Arg Ser Asp Asp Ile 
945                 950                 955                 960 


Thr Leu Asn Leu Asp His Gln Leu Leu Gly Leu Gly Ser Asn Ser Trp 
                965                 970                 975     


Gly Ser Glu Val Leu Asp Ser Trp Arg Val Trp Phe Arg Asp Phe Ser 
            980                 985                 990         


Tyr Gly Phe Thr Leu Leu Pro Val  Ser Gly Gly Glu Ala  Thr Ala Gln 
        995                 1000                 1005             


Ser Leu  Ala Ser Tyr Glu Phe  Gly Ala Gly Phe Phe  Ser Thr Asn 
    1010                 1015                 1020             


Leu His  Ser Glu Asn Lys Gln  
    1025                 1030 


<210>  326
<211>  3141
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 320

<400>  326
atggaggtaa tgaaagtgga acagaaatat gtcgagagct tctaccctcc ttcggactat     60

cggttgcccc ctcgtgcgtt cttcataccg cactcgacag agcgagaagc gctcgcacgc    120

ggattctacc gtgcgtcgac acaagtgtta ccattagaag gaaagtggaa gtttcgcctg    180

tttgacaatc ctcgcgctgt gccgacggac gtgacttgga tcgatttcga cgactcctca    240

tgggaagaaa tacacgtgcc gtcgaactgg cagatggagg gctatggacg gccacactac    300

acaaacgtga tgtacccctt tcctgttgac ccgccccggg ttccttcgga aaacccgacg    360

ggttgttaca gaaccaaatt ttttctgaca catcacgatg taggcagggt acacttgagg    420

tttgaagggg tcgacggatt gtatcaagtt tacgtgaacg gtcatgatat cggtttcgga    480

tatggtagcc gattgccctc ggaatttgat attacggact ttgttcatgc cggtgacaat    540

gtacttgtcg tggttgtgtg tcagtggtca gctcagtctt atcttgaaga tcaggacatg    600

tggtggttgt ctgggatttt tagagacgta tacattctga agagacctca gatctattta    660

tccgatgttc gggttcgagc actcttgggg actgacggac ggacagggtg tttacatgta    720

gaagtggaga ttgggggaat tttatcacgc gataagcctg ttcccttgag gtttaagctg    780

attgatagca taggggatag tgaaatcctt gaaaacacga tgttgtccga tggattcgcg    840

acttacgagg ccgagatccc taacgtacga ccgtggacag cggaaacgcc caacctgtat    900

acgttgctgg tatcaataga tccggattcc ttgtacgcgg aacatgttgc gttacaagta    960

ggatttagga gaattgagat tgccgatggg cagctgaaga tcaatggagt ccctattgtg   1020

ctcaaaggag taaacaggca tgagcacgac gcccgtctgg gccgagcttt gacgctggat   1080

gtgatgattc gcgatgtgca gatgatgaaa cagaacaaca ttaatgccgt tcgtaccagt   1140

cattaccctc accatcctgt gttctatgat ctgtgtgatc gctacggttt gtatgttcta   1200

gacgaagctg atctcgagtg ccacggcttc gcattgacag ggaactggga ccgattgagt   1260

gacgacccgc agttggaaca ggcgtacgtt gatcgcctgg agcggatgat ctgccgcgac   1320

cgcaatcatg cgtgtgtaat tatgtggtct cttggtaatg agtctgggta tggtcgtaac   1380

catagagcca tggcagaacg ggcaagggcc atagacccga cgagacccgt acactacgaa   1440

ggtgaaacaa ggaggctgct agagcttggt tctgatttac aacacgccgt gatggatgtg   1500

tacagcacaa tgtacacatc cgtcgatgaa ttgagcaggc ttggggaatt ggagcttcct   1560

aaaccacata tattatgtga atttgcccat gcgatgggga acgggccagg tggtcttaag   1620

gagtacgttg agctatttta tcaacagcga aggttgcagg gtgggtttgt atgggagtgg   1680

attgatcacg gaattctggc ctatacatct gatggcagac cgtacttcgc gtacggcggt   1740

gattttggag atgttccgaa cgacttaaat ttcgttattg acggactgtt atttcctgac   1800

cgaactcctt cgccggggct tttcgagtac aagaaagcaa ttgagccggt aagagttctt   1860

gagttcgatc gttcatcagg gatcatcaag gtccagaacc gctatgattt tctctgtctc   1920

gattgcctag tagcggagtg gtcgcttcag gatgaacagt cagtgttggc cggtggcata   1980

cttgaactag agccagtacc acccaggagc attggacaaa taagggtacc atgcgccgaa   2040

atccttaatc ggcacagaga tcggtgcttg actctgactg taagattcct tttgcgccac   2100

ccaaccgact atgcgccagc gttccacgaa gttgcgagtt tttgcgagta tgttgaacgc   2160

agttgccaga atgcaagcat cgacatatat cggccggtta caagatttga aatcgtagaa   2220

aagggtagta gtctatgcat ctatgacgat tcgttctccg ttgagttcga tttgctacgg   2280

gggaggatct ctggggtagg atatcgtggc tcacaaatca ttatgtcacc gctctcaatg   2340

tcgttttgga gagcgcctac agataatgac gatccaccga atcgagaaat gttttcggtt   2400

gccaaagtat ggcgcgatta cggtgtcgat cggctctcag agtccgtgtc aaacatagaa   2460

atcaaaaaac atgacaacgt cgtgcgcgct ctagttgagt cgcgtgtcgc gcctgccggg   2520

ctctcctggg gtatggcgtt gcagtatgag tacattttct tacgcggtgg gttggtcatg   2580

gtacgaattt gcggtaaacc cgaaggagct tatcctccaa ccttgcctcg tataggactg   2640

ttaacgacca ttcacctcga cttcgaatac gtgagttggt ttggacgagg acccggtgag   2700

agttaccgcg attctaagga gtcacaactc attgggagat ataggaggtt ggctgatgaa   2760

ctttataccc cgtatgtgta tccgcaagag aacggtaatc ggacagatgt gtattggatc   2820

tcgattacaa ataaatacat ggagggtctg ttcataacag gcccacaacc tttgaatttt   2880

caagtgagca gattcagtgt ggaggacctc gagcgcgctc ggcatccata tgagttagaa   2940

gaaagtcctt ggagatacct ccgaattgac ttttctcacc atgggcttgg cagcgcgagt   3000

tgtggtcctg gtcctcttcc tgagcatcaa ttgcgtactg agccattcga atggactctg   3060

tgcttcgcac ccctcgcgcg acacgagatc gatgagtcga tcctccatca agtggtcacg   3120

gaaaggttga agttcattta g                                             3141


<210>  327
<211>  3141
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 320

<400>  327
atggaggtaa tgcgaataga acagaaatat gtcgagagct tctaccctcc ttcggactat     60

cggttgcccc ctcgtgcgtt cttcataccg cactcgacag agcgagaagc gctcgcacgc    120

ggattctacc gtgcgtcgac acaagtgtta ccattagaag gaaagtggaa gtttcgcctg    180

tttgacaatc ctcgcgctgt gccgacggac gtgacttgga tcgatttcga cgactcctca    240

tgggaagaaa tacacgtgcc gtcgaactgg cagatggagg gctatggacg gccacactac    300

acaaacgtga tgtacccctt tcctgttgac ccgccccggg ttccttcgga aaacccgacg    360

ggttgttaca gaaccaaatt ttttctgaca catcacgatg taggcagggt acacttgagg    420

tttgaagggg tcgacggatt gtatcaagtt tacgtgaacg gtcatgatat cggtttcgga    480

tatggtagcc gattgccctc ggaatttgat attacggact ttgttcatgc cggtgacaat    540

gtacttgtcg tggttgtgtg tcagtggtca gctcagtctt atcttgaaga tcaggacatg    600

tggtggttgt ctgggatttt tagagacgta tacattctga agagacctca gatctattta    660

tccgatgttc gggttcgagc actcttgggg actgacggac ggacagggtg tttacatgta    720

gaagtggaga ttgggggaat tttatcacgc gataagcctg ttcccttgag gtttaagctg    780

attgatagca taggggatag tgaaatcctt gaaaacacga tgttgtccga tggattcgcg    840

acttacgagg ccgagatccc taacgtacga ccgtggacag cggaaacgcc caacctgtat    900

acgttgctgg tatcaataga tccggattcc ttgtacgcgg aacatgttgc gttacaagta    960

ggatttagga gaattgagat tgccgatggg cagctgaaga tcaatggagt ccctattgtg   1020

ctcaaaggag taaacaggca tgagcacgac gcccgtctgg gccgagcttt gacgctggat   1080

gtgatgattc gcgatgtgca gatgatgaaa cagaacaaca ttaatgccgt tcgtaccagt   1140

cattaccctc accatcctgt gttctatgat ctgtgtgatc gctacggttt gtatgttcta   1200

gacgaagctg atctcgagtg ccacggcttc gcattgacag ggaactggga ccgattgagt   1260

gacgacccgc agttggaaca ggcgtacgtt gatcgcctgg agcggatgat ctgccgcgac   1320

cgcaatcatg cgtgtgtaat tatgtggtct cttggtaatg agtctgggta tggtcgtaac   1380

catagagcca tggcagaacg ggcaagggcc atagacccga cgagacccgt acactacgaa   1440

ggtgaaacaa ggaggctgct agagcttggt tctgatttac aacacgccgt gatggatgtg   1500

tacagcacaa tgtacacatc cgtcgatgaa ttgagcaggc ttggggaatt ggagcttcct   1560

aaaccacata tattatgtga atttgcccat gcgatgggga acgggccagg tggtcttaag   1620

gagtacgttg agctatttta tcaacagcga aggttgcagg gtgggtttgt atgggagtgg   1680

attgatcacg gaattctggc ctatacatct gatggcagac cgtacttcgc gtacggcggt   1740

gattttggag atgttccgaa cgacttaaat ttcgttattg acggactgtt atttcctgac   1800

cgaactcctt cgccggggct tttcgagtac aagaaagcaa ttgagccggt aagagttctt   1860

gagttcgatc gttcatcagg gatcatcaag gtccagaacc gctatgattt tctctgtctc   1920

gattgcctag tagcggagtg gtcgcttcag gatgaacagt cagtgttggc cggtggcata   1980

cttgaactag agccagtacc acccaggagc attggacaaa taagggtacc atgcgccgaa   2040

atccttaatc ggcacagaga tcggtgcttg actctgactg taagattcct tttgcgccac   2100

ccaaccgact atgcgccagc gttccacgaa gttgcgagtt tttgcgagta tgttgaacgc   2160

agttgccaga atgcaagcat cgacatatat cggccggtta caagatttga aatcgtagaa   2220

aagggtagta gtctatgcat ctatgacgat tcgttctccg ttgagttcga tttgctacgg   2280

gggaggatct ctggggtagg atatcgtggc tcacaaatca ttatgtcacc gctctcaatg   2340

tcgttttgga gagcgcctac agataatgac gatccaccga atcgagaaat gttttcggtt   2400

gccaaagtat ggcgcgatta cggtgtcgat cggctctcag agtccgtgtc aaacatagaa   2460

atcaaaaaac atgacaacgt cgtgcgcgct ctagttgagt cgcgtgtcgc gcctgccggg   2520

ctctcctggg gtatggcgtt gcagtatgag tacattttct tacgcggtgg gttggtcatg   2580

gtacgaattt gcggtaaacc cgaaggagct tatcctccaa ccttgcctcg tataggactg   2640

ttaacgacca ttcacctcga cttcgaatac gtgagttggt ttggacgagg acccggtgag   2700

agttaccgcg attctaagga gtcacaactc attgggagat ataggaggtt ggctgatgaa   2760

ctttataccc cgtatgtgta tccgcaagag aacggtaatc ggacagatgt gtattggatc   2820

tcgattacaa ataaatacat ggagggtctg ttcataacag gcccacaacc tttgaatttt   2880

caagtgagca gattcagtgt ggaggacctc gagcgcgctc ggcatccata tgagttagaa   2940

gaaagtcctt ggagatacct ccgaattgac ttttctcacc atgggcttgg cagcgcgagt   3000

tgtggtcctg gtcctcttcc tgagcatcaa ttgcgtactg agccattcga atggactctg   3060

tgcttcgcac ccctcgcgcg acacgagatc gatgagtcga tcctccatca agtggtcacg   3120

gaaaggttga agttcattta g                                             3141


<210>  328
<211>  3141
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 320

<400>  328
atggaggtaa tgcgactgga acagaaatat gtcgagagct tctaccctcc ttcggactat     60

cggttgcccc ctcgtgcgtt cttcataccg cactcgacag agcgagaagc gctcgcacgc    120

ggattctacc gtgcgtcgac acaagtgtta ccattagaag gaaagtggaa gtttcgcctg    180

tttgacaatc ctcgcgctgt gccgacggac gtgacttgga tcgatttcga cgactcctca    240

tgggaagaaa tacacgtgcc gtcgaactgg cagatggagg gctatggacg gccacactac    300

acaaacgtga tgtacccctt tcctgttgac ccgccccggg ttccttcgga aaacccgacg    360

ggttgttaca gaaccaaatt ttttctgaca catcacgatg taggcagggt acacttgagg    420

tttgaagggg tcgacggatt gtatcaagtt tacgtgaacg gtcatgatat cggtttcgga    480

tatggtagcc gattgccctc ggaatttgat attacggact ttgttcatgc cggtgacaat    540

gtacttgtcg tggttgtgtg tcagtggtca gctcagtctt atcttgaaga tcaggacatg    600

tggtggttgt ctgggatttt tagagacgta tacattctga agagacctca gatctattta    660

tccgatgttc gggttcgagc actcttgggg actgacggac ggacagggtg tttacatgta    720

gaagtggaga ttgggggaat tttatcacgc gataagcctg ttcccttgag gtttaagctg    780

attgatagca taggggatag tgaaatcctt gaaaacacga tgttgtccga tggattcgcg    840

acttacgagg ccgagatccc taacgtacga ccgtggacag cggaaacgcc caacctgtat    900

acgttgctgg tatcaataga tccggattcc ttgtacgcgg aacatgttgc gttacaagta    960

ggatttagga gaattgagat tgccgatggg cagctgaaga tcaatggagt ccctattgtg   1020

ctcaaaggag taaacaggca tgagcacgac gcccgtctgg gccgagcttt gacgctggat   1080

gtgatgattc gcgatgtgca gatgatgaaa cagaacaaca ttaatgccgt tcgtaccagt   1140

cattaccctc accatcctgt gttctatgat ctgtgtgatc gctacggttt gtatgttcta   1200

gacgaagctg atctcgagtg ccacggcttc gcattgacag ggaactggga ccgattgagt   1260

gacgacccgc agttggaaca ggcgtacgtt gatcgcctgg agcggatgat ctgccgcgac   1320

cgcaatcatg cgtgtgtaat tatgtggtct cttggtaatg agtctgggta tggtcgtaac   1380

catagagcca tggcagaacg ggcaagggcc atagacccga cgagacccgt acactacgaa   1440

ggtgaaacaa ggaggctgct agagcttggt tctgatttac aacacgccgt gatggatgtg   1500

tacagcacaa tgtacacatc cgtcgatgaa ttgagcaggc ttggggaatt ggagcttcct   1560

aaaccacata tattatgtga atttgcccat gcgatgggga acgggccagg tggtcttaag   1620

gagtacgttg agctatttta tcaacagcga aggttgcagg gtgggtttgt atgggagtgg   1680

attgatcacg gaattctggc ctatacatct gatggcagac cgtacttcgc gtacggcggt   1740

gattttggag atgttccgaa cgacttaaat ttcgttattg acggactgtt atttcctgac   1800

cgaactcctt cgccggggct tttcgagtac aagaaagcaa ttgagccggt aagagttctt   1860

gagttcgatc gttcatcagg gatcatcaag gtccagaacc gctatgattt tctctgtctc   1920

gattgcctag tagcggagtg gtcgcttcag gatgaacagt cagtgttggc cggtggcata   1980

cttgaactag agccagtacc acccaggagc attggacaaa taagggtacc atgcgccgaa   2040

atccttaatc ggcacagaga tcggtgcttg actctgactg taagattcct tttgcgccac   2100

ccaaccgact atgcgccagc gttccacgaa gttgcgagtt tttgcgagta tgttgaacgc   2160

agttgccaga atgcaagcat cgacatatat cggccggtta caagatttga aatcgtagaa   2220

aagggtagta gtctatgcat ctatgacgat tcgttctccg ttgagttcga tttgctacgg   2280

gggaggatct ctggggtagg atatcgtggc tcacaaatca ttatgtcacc gctctcaatg   2340

tcgttttgga gagcgcctac agataatgac gatccaccga atcgagaaat gttttcggtt   2400

gccaaagtat ggcgcgatta cggtgtcgat cggctctcag agtccgtgtc aaacatagaa   2460

atcaaaaaac atgacaacgt cgtgcgcgct ctagttgagt cgcgtgtcgc gcctgccggg   2520

ctctcctggg gtatggcgtt gcagtatgag tacattttct tacgcggtgg gttggtcatg   2580

gtacgaattt gcggtaaacc cgaaggagct tatcctccaa ccttgcctcg tataggactg   2640

ttaacgacca ttcacctcga cttcgaatac gtgagttggt ttggacgagg acccggtgag   2700

agttaccgcg attctaagga gtcacaactc attgggagat ataggaggtt ggctgatgaa   2760

ctttataccc cgtatgtgta tccgcaagag aacggtaatc ggacagatgt gtattggatc   2820

tcgattacaa ataaatacat ggagggtctg ttcataacag gcccacaacc tttgaatttt   2880

caagtgagca gattcagtgt ggaggacctc gagcgcgctc ggcatccata tgagttagaa   2940

gaaagtcctt ggagatacct ccgaattgac ttttctcacc atgggcttgg cagcgcgagt   3000

tgtggtcctg gtcctcttcc tgagcatcaa ttgcgtactg agccattcga atggactctg   3060

tgcttcgcac ccctcgcgcg acacgagatc gatgagtcga tcctccatca agtggtcacg   3120

gaaaggttga agttcattta g                                             3141


<210>  329
<211>  3141
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 320

<400>  329
atggaggtaa tgcgagtgga aaacaaatat gtcgagagct tctaccctcc ttcggactat     60

cggttgcccc ctcgtgcgtt cttcataccg cactcgacag agcgagaagc gctcgcacgc    120

ggattctacc gtgcgtcgac acaagtgtta ccattagaag gaaagtggaa gtttcgcctg    180

tttgacaatc ctcgcgctgt gccgacggac gtgacttgga tcgatttcga cgactcctca    240

tgggaagaaa tacacgtgcc gtcgaactgg cagatggagg gctatggacg gccacactac    300

acaaacgtga tgtacccctt tcctgttgac ccgccccggg ttccttcgga aaacccgacg    360

ggttgttaca gaaccaaatt ttttctgaca catcacgatg taggcagggt acacttgagg    420

tttgaagggg tcgacggatt gtatcaagtt tacgtgaacg gtcatgatat cggtttcgga    480

tatggtagcc gattgccctc ggaatttgat attacggact ttgttcatgc cggtgacaat    540

gtacttgtcg tggttgtgtg tcagtggtca gctcagtctt atcttgaaga tcaggacatg    600

tggtggttgt ctgggatttt tagagacgta tacattctga agagacctca gatctattta    660

tccgatgttc gggttcgagc actcttgggg actgacggac ggacagggtg tttacatgta    720

gaagtggaga ttgggggaat tttatcacgc gataagcctg ttcccttgag gtttaagctg    780

attgatagca taggggatag tgaaatcctt gaaaacacga tgttgtccga tggattcgcg    840

acttacgagg ccgagatccc taacgtacga ccgtggacag cggaaacgcc caacctgtat    900

acgttgctgg tatcaataga tccggattcc ttgtacgcgg aacatgttgc gttacaagta    960

ggatttagga gaattgagat tgccgatggg cagctgaaga tcaatggagt ccctattgtg   1020

ctcaaaggag taaacaggca tgagcacgac gcccgtctgg gccgagcttt gacgctggat   1080

gtgatgattc gcgatgtgca gatgatgaaa cagaacaaca ttaatgccgt tcgtaccagt   1140

cattaccctc accatcctgt gttctatgat ctgtgtgatc gctacggttt gtatgttcta   1200

gacgaagctg atctcgagtg ccacggcttc gcattgacag ggaactggga ccgattgagt   1260

gacgacccgc agttggaaca ggcgtacgtt gatcgcctgg agcggatgat ctgccgcgac   1320

cgcaatcatg cgtgtgtaat tatgtggtct cttggtaatg agtctgggta tggtcgtaac   1380

catagagcca tggcagaacg ggcaagggcc atagacccga cgagacccgt acactacgaa   1440

ggtgaaacaa ggaggctgct agagcttggt tctgatttac aacacgccgt gatggatgtg   1500

tacagcacaa tgtacacatc cgtcgatgaa ttgagcaggc ttggggaatt ggagcttcct   1560

aaaccacata tattatgtga atttgcccat gcgatgggga acgggccagg tggtcttaag   1620

gagtacgttg agctatttta tcaacagcga aggttgcagg gtgggtttgt atgggagtgg   1680

attgatcacg gaattctggc ctatacatct gatggcagac cgtacttcgc gtacggcggt   1740

gattttggag atgttccgaa cgacttaaat ttcgttattg acggactgtt atttcctgac   1800

cgaactcctt cgccggggct tttcgagtac aagaaagcaa ttgagccggt aagagttctt   1860

gagttcgatc gttcatcagg gatcatcaag gtccagaacc gctatgattt tctctgtctc   1920

gattgcctag tagcggagtg gtcgcttcag gatgaacagt cagtgttggc cggtggcata   1980

cttgaactag agccagtacc acccaggagc attggacaaa taagggtacc atgcgccgaa   2040

atccttaatc ggcacagaga tcggtgcttg actctgactg taagattcct tttgcgccac   2100

ccaaccgact atgcgccagc gttccacgaa gttgcgagtt tttgcgagta tgttgaacgc   2160

agttgccaga atgcaagcat cgacatatat cggccggtta caagatttga aatcgtagaa   2220

aagggtagta gtctatgcat ctatgacgat tcgttctccg ttgagttcga tttgctacgg   2280

gggaggatct ctggggtagg atatcgtggc tcacaaatca ttatgtcacc gctctcaatg   2340

tcgttttgga gagcgcctac agataatgac gatccaccga atcgagaaat gttttcggtt   2400

gccaaagtat ggcgcgatta cggtgtcgat cggctctcag agtccgtgtc aaacatagaa   2460

atcaaaaaac atgacaacgt cgtgcgcgct ctagttgagt cgcgtgtcgc gcctgccggg   2520

ctctcctggg gtatggcgtt gcagtatgag tacattttct tacgcggtgg gttggtcatg   2580

gtacgaattt gcggtaaacc cgaaggagct tatcctccaa ccttgcctcg tataggactg   2640

ttaacgacca ttcacctcga cttcgaatac gtgagttggt ttggacgagg acccggtgag   2700

agttaccgcg attctaagga gtcacaactc attgggagat ataggaggtt ggctgatgaa   2760

ctttataccc cgtatgtgta tccgcaagag aacggtaatc ggacagatgt gtattggatc   2820

tcgattacaa ataaatacat ggagggtctg ttcataacag gcccacaacc tttgaatttt   2880

caagtgagca gattcagtgt ggaggacctc gagcgcgctc ggcatccata tgagttagaa   2940

gaaagtcctt ggagatacct ccgaattgac ttttctcacc atgggcttgg cagcgcgagt   3000

tgtggtcctg gtcctcttcc tgagcatcaa ttgcgtactg agccattcga atggactctg   3060

tgcttcgcac ccctcgcgcg acacgagatc gatgagtcga tcctccatca agtggtcacg   3120

gaaaggttga agttcattta g                                             3141


<210>  330
<211>  3141
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 320

<400>  330
atggaggtaa tgcgagtgga acagagatat gtcgagagct tctaccctcc ttcggactat     60

cggttgcccc ctcgtgcgtt cttcataccg cactcgacag agcgagaagc gctcgcacgc    120

ggattctacc gtgcgtcgac acaagtgtta ccattagaag gaaagtggaa gtttcgcctg    180

tttgacaatc ctcgcgctgt gccgacggac gtgacttgga tcgatttcga cgactcctca    240

tgggaagaaa tacacgtgcc gtcgaactgg cagatggagg gctatggacg gccacactac    300

acaaacgtga tgtacccctt tcctgttgac ccgccccggg ttccttcgga aaacccgacg    360

ggttgttaca gaaccaaatt ttttctgaca catcacgatg taggcagggt acacttgagg    420

tttgaagggg tcgacggatt gtatcaagtt tacgtgaacg gtcatgatat cggtttcgga    480

tatggtagcc gattgccctc ggaatttgat attacggact ttgttcatgc cggtgacaat    540

gtacttgtcg tggttgtgtg tcagtggtca gctcagtctt atcttgaaga tcaggacatg    600

tggtggttgt ctgggatttt tagagacgta tacattctga agagacctca gatctattta    660

tccgatgttc gggttcgagc actcttgggg actgacggac ggacagggtg tttacatgta    720

gaagtggaga ttgggggaat tttatcacgc gataagcctg ttcccttgag gtttaagctg    780

attgatagca taggggatag tgaaatcctt gaaaacacga tgttgtccga tggattcgcg    840

acttacgagg ccgagatccc taacgtacga ccgtggacag cggaaacgcc caacctgtat    900

acgttgctgg tatcaataga tccggattcc ttgtacgcgg aacatgttgc gttacaagta    960

ggatttagga gaattgagat tgccgatggg cagctgaaga tcaatggagt ccctattgtg   1020

ctcaaaggag taaacaggca tgagcacgac gcccgtctgg gccgagcttt gacgctggat   1080

gtgatgattc gcgatgtgca gatgatgaaa cagaacaaca ttaatgccgt tcgtaccagt   1140

cattaccctc accatcctgt gttctatgat ctgtgtgatc gctacggttt gtatgttcta   1200

gacgaagctg atctcgagtg ccacggcttc gcattgacag ggaactggga ccgattgagt   1260

gacgacccgc agttggaaca ggcgtacgtt gatcgcctgg agcggatgat ctgccgcgac   1320

cgcaatcatg cgtgtgtaat tatgtggtct cttggtaatg agtctgggta tggtcgtaac   1380

catagagcca tggcagaacg ggcaagggcc atagacccga cgagacccgt acactacgaa   1440

ggtgaaacaa ggaggctgct agagcttggt tctgatttac aacacgccgt gatggatgtg   1500

tacagcacaa tgtacacatc cgtcgatgaa ttgagcaggc ttggggaatt ggagcttcct   1560

aaaccacata tattatgtga atttgcccat gcgatgggga acgggccagg tggtcttaag   1620

gagtacgttg agctatttta tcaacagcga aggttgcagg gtgggtttgt atgggagtgg   1680

attgatcacg gaattctggc ctatacatct gatggcagac cgtacttcgc gtacggcggt   1740

gattttggag atgttccgaa cgacttaaat ttcgttattg acggactgtt atttcctgac   1800

cgaactcctt cgccggggct tttcgagtac aagaaagcaa ttgagccggt aagagttctt   1860

gagttcgatc gttcatcagg gatcatcaag gtccagaacc gctatgattt tctctgtctc   1920

gattgcctag tagcggagtg gtcgcttcag gatgaacagt cagtgttggc cggtggcata   1980

cttgaactag agccagtacc acccaggagc attggacaaa taagggtacc atgcgccgaa   2040

atccttaatc ggcacagaga tcggtgcttg actctgactg taagattcct tttgcgccac   2100

ccaaccgact atgcgccagc gttccacgaa gttgcgagtt tttgcgagta tgttgaacgc   2160

agttgccaga atgcaagcat cgacatatat cggccggtta caagatttga aatcgtagaa   2220

aagggtagta gtctatgcat ctatgacgat tcgttctccg ttgagttcga tttgctacgg   2280

gggaggatct ctggggtagg atatcgtggc tcacaaatca ttatgtcacc gctctcaatg   2340

tcgttttgga gagcgcctac agataatgac gatccaccga atcgagaaat gttttcggtt   2400

gccaaagtat ggcgcgatta cggtgtcgat cggctctcag agtccgtgtc aaacatagaa   2460

atcaaaaaac atgacaacgt cgtgcgcgct ctagttgagt cgcgtgtcgc gcctgccggg   2520

ctctcctggg gtatggcgtt gcagtatgag tacattttct tacgcggtgg gttggtcatg   2580

gtacgaattt gcggtaaacc cgaaggagct tatcctccaa ccttgcctcg tataggactg   2640

ttaacgacca ttcacctcga cttcgaatac gtgagttggt ttggacgagg acccggtgag   2700

agttaccgcg attctaagga gtcacaactc attgggagat ataggaggtt ggctgatgaa   2760

ctttataccc cgtatgtgta tccgcaagag aacggtaatc ggacagatgt gtattggatc   2820

tcgattacaa ataaatacat ggagggtctg ttcataacag gcccacaacc tttgaatttt   2880

caagtgagca gattcagtgt ggaggacctc gagcgcgctc ggcatccata tgagttagaa   2940

gaaagtcctt ggagatacct ccgaattgac ttttctcacc atgggcttgg cagcgcgagt   3000

tgtggtcctg gtcctcttcc tgagcatcaa ttgcgtactg agccattcga atggactctg   3060

tgcttcgcac ccctcgcgcg acacgagatc gatgagtcga tcctccatca agtggtcacg   3120

gaaaggttga agttcattta g                                             3141


<210>  331
<211>  1046
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:321 and encoded by SEQ ID NO:326

<400>  331

Met Glu Val Met Lys Val Glu Gln Lys Tyr Val Glu Ser Phe Tyr Pro 
1               5                   10                  15      


Pro Ser Asp Tyr Arg Leu Pro Pro Arg Ala Phe Phe Ile Pro His Ser 
            20                  25                  30          


Thr Glu Arg Glu Ala Leu Ala Arg Gly Phe Tyr Arg Ala Ser Thr Gln 
        35                  40                  45              


Val Leu Pro Leu Glu Gly Lys Trp Lys Phe Arg Leu Phe Asp Asn Pro 
    50                  55                  60                  


Arg Ala Val Pro Thr Asp Val Thr Trp Ile Asp Phe Asp Asp Ser Ser 
65                  70                  75                  80  


Trp Glu Glu Ile His Val Pro Ser Asn Trp Gln Met Glu Gly Tyr Gly 
                85                  90                  95      


Arg Pro His Tyr Thr Asn Val Met Tyr Pro Phe Pro Val Asp Pro Pro 
            100                 105                 110         


Arg Val Pro Ser Glu Asn Pro Thr Gly Cys Tyr Arg Thr Lys Phe Phe 
        115                 120                 125             


Leu Thr His His Asp Val Gly Arg Val His Leu Arg Phe Glu Gly Val 
    130                 135                 140                 


Asp Gly Leu Tyr Gln Val Tyr Val Asn Gly His Asp Ile Gly Phe Gly 
145                 150                 155                 160 


Tyr Gly Ser Arg Leu Pro Ser Glu Phe Asp Ile Thr Asp Phe Val His 
                165                 170                 175     


Ala Gly Asp Asn Val Leu Val Val Val Val Cys Gln Trp Ser Ala Gln 
            180                 185                 190         


Ser Tyr Leu Glu Asp Gln Asp Met Trp Trp Leu Ser Gly Ile Phe Arg 
        195                 200                 205             


Asp Val Tyr Ile Leu Lys Arg Pro Gln Ile Tyr Leu Ser Asp Val Arg 
    210                 215                 220                 


Val Arg Ala Leu Leu Gly Thr Asp Gly Arg Thr Gly Cys Leu His Val 
225                 230                 235                 240 


Glu Val Glu Ile Gly Gly Ile Leu Ser Arg Asp Lys Pro Val Pro Leu 
                245                 250                 255     


Arg Phe Lys Leu Ile Asp Ser Ile Gly Asp Ser Glu Ile Leu Glu Asn 
            260                 265                 270         


Thr Met Leu Ser Asp Gly Phe Ala Thr Tyr Glu Ala Glu Ile Pro Asn 
        275                 280                 285             


Val Arg Pro Trp Thr Ala Glu Thr Pro Asn Leu Tyr Thr Leu Leu Val 
    290                 295                 300                 


Ser Ile Asp Pro Asp Ser Leu Tyr Ala Glu His Val Ala Leu Gln Val 
305                 310                 315                 320 


Gly Phe Arg Arg Ile Glu Ile Ala Asp Gly Gln Leu Lys Ile Asn Gly 
                325                 330                 335     


Val Pro Ile Val Leu Lys Gly Val Asn Arg His Glu His Asp Ala Arg 
            340                 345                 350         


Leu Gly Arg Ala Leu Thr Leu Asp Val Met Ile Arg Asp Val Gln Met 
        355                 360                 365             


Met Lys Gln Asn Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro His 
    370                 375                 380                 


His Pro Val Phe Tyr Asp Leu Cys Asp Arg Tyr Gly Leu Tyr Val Leu 
385                 390                 395                 400 


Asp Glu Ala Asp Leu Glu Cys His Gly Phe Ala Leu Thr Gly Asn Trp 
                405                 410                 415     


Asp Arg Leu Ser Asp Asp Pro Gln Leu Glu Gln Ala Tyr Val Asp Arg 
            420                 425                 430         


Leu Glu Arg Met Ile Cys Arg Asp Arg Asn His Ala Cys Val Ile Met 
        435                 440                 445             


Trp Ser Leu Gly Asn Glu Ser Gly Tyr Gly Arg Asn His Arg Ala Met 
    450                 455                 460                 


Ala Glu Arg Ala Arg Ala Ile Asp Pro Thr Arg Pro Val His Tyr Glu 
465                 470                 475                 480 


Gly Glu Thr Arg Arg Leu Leu Glu Leu Gly Ser Asp Leu Gln His Ala 
                485                 490                 495     


Val Met Asp Val Tyr Ser Thr Met Tyr Thr Ser Val Asp Glu Leu Ser 
            500                 505                 510         


Arg Leu Gly Glu Leu Glu Leu Pro Lys Pro His Ile Leu Cys Glu Phe 
        515                 520                 525             


Ala His Ala Met Gly Asn Gly Pro Gly Gly Leu Lys Glu Tyr Val Glu 
    530                 535                 540                 


Leu Phe Tyr Gln Gln Arg Arg Leu Gln Gly Gly Phe Val Trp Glu Trp 
545                 550                 555                 560 


Ile Asp His Gly Ile Leu Ala Tyr Thr Ser Asp Gly Arg Pro Tyr Phe 
                565                 570                 575     


Ala Tyr Gly Gly Asp Phe Gly Asp Val Pro Asn Asp Leu Asn Phe Val 
            580                 585                 590         


Ile Asp Gly Leu Leu Phe Pro Asp Arg Thr Pro Ser Pro Gly Leu Phe 
        595                 600                 605             


Glu Tyr Lys Lys Ala Ile Glu Pro Val Arg Val Leu Glu Phe Asp Arg 
    610                 615                 620                 


Ser Ser Gly Ile Ile Lys Val Gln Asn Arg Tyr Asp Phe Leu Cys Leu 
625                 630                 635                 640 


Asp Cys Leu Val Ala Glu Trp Ser Leu Gln Asp Glu Gln Ser Val Leu 
                645                 650                 655     


Ala Gly Gly Ile Leu Glu Leu Glu Pro Val Pro Pro Arg Ser Ile Gly 
            660                 665                 670         


Gln Ile Arg Val Pro Cys Ala Glu Ile Leu Asn Arg His Arg Asp Arg 
        675                 680                 685             


Cys Leu Thr Leu Thr Val Arg Phe Leu Leu Arg His Pro Thr Asp Tyr 
    690                 695                 700                 


Ala Pro Ala Phe His Glu Val Ala Ser Phe Cys Glu Tyr Val Glu Arg 
705                 710                 715                 720 


Ser Cys Gln Asn Ala Ser Ile Asp Ile Tyr Arg Pro Val Thr Arg Phe 
                725                 730                 735     


Glu Ile Val Glu Lys Gly Ser Ser Leu Cys Ile Tyr Asp Asp Ser Phe 
            740                 745                 750         


Ser Val Glu Phe Asp Leu Leu Arg Gly Arg Ile Ser Gly Val Gly Tyr 
        755                 760                 765             


Arg Gly Ser Gln Ile Ile Met Ser Pro Leu Ser Met Ser Phe Trp Arg 
    770                 775                 780                 


Ala Pro Thr Asp Asn Asp Asp Pro Pro Asn Arg Glu Met Phe Ser Val 
785                 790                 795                 800 


Ala Lys Val Trp Arg Asp Tyr Gly Val Asp Arg Leu Ser Glu Ser Val 
                805                 810                 815     


Ser Asn Ile Glu Ile Lys Lys His Asp Asn Val Val Arg Ala Leu Val 
            820                 825                 830         


Glu Ser Arg Val Ala Pro Ala Gly Leu Ser Trp Gly Met Ala Leu Gln 
        835                 840                 845             


Tyr Glu Tyr Ile Phe Leu Arg Gly Gly Leu Val Met Val Arg Ile Cys 
    850                 855                 860                 


Gly Lys Pro Glu Gly Ala Tyr Pro Pro Thr Leu Pro Arg Ile Gly Leu 
865                 870                 875                 880 


Leu Thr Thr Ile His Leu Asp Phe Glu Tyr Val Ser Trp Phe Gly Arg 
                885                 890                 895     


Gly Pro Gly Glu Ser Tyr Arg Asp Ser Lys Glu Ser Gln Leu Ile Gly 
            900                 905                 910         


Arg Tyr Arg Arg Leu Ala Asp Glu Leu Tyr Thr Pro Tyr Val Tyr Pro 
        915                 920                 925             


Gln Glu Asn Gly Asn Arg Thr Asp Val Tyr Trp Ile Ser Ile Thr Asn 
    930                 935                 940                 


Lys Tyr Met Glu Gly Leu Phe Ile Thr Gly Pro Gln Pro Leu Asn Phe 
945                 950                 955                 960 


Gln Val Ser Arg Phe Ser Val Glu Asp Leu Glu Arg Ala Arg His Pro 
                965                 970                 975     


Tyr Glu Leu Glu Glu Ser Pro Trp Arg Tyr Leu Arg Ile Asp Phe Ser 
            980                 985                 990         


His His Gly Leu Gly Ser Ala Ser  Cys Gly Pro Gly Pro  Leu Pro Glu 
        995                 1000                 1005             


His Gln  Leu Arg Thr Glu Pro  Phe Glu Trp Thr Leu  Cys Phe Ala 
    1010                 1015                 1020             


Pro Leu  Ala Arg His Glu Ile  Asp Glu Ser Ile Leu  His Gln Val 
    1025                 1030                 1035             


Val Thr  Glu Arg Leu Lys Phe  Ile 
    1040                 1045     


<210>  332
<211>  1046
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:321 and encoded by SEQ ID NO:327

<400>  332

Met Glu Val Met Arg Ile Glu Gln Lys Tyr Val Glu Ser Phe Tyr Pro 
1               5                   10                  15      


Pro Ser Asp Tyr Arg Leu Pro Pro Arg Ala Phe Phe Ile Pro His Ser 
            20                  25                  30          


Thr Glu Arg Glu Ala Leu Ala Arg Gly Phe Tyr Arg Ala Ser Thr Gln 
        35                  40                  45              


Val Leu Pro Leu Glu Gly Lys Trp Lys Phe Arg Leu Phe Asp Asn Pro 
    50                  55                  60                  


Arg Ala Val Pro Thr Asp Val Thr Trp Ile Asp Phe Asp Asp Ser Ser 
65                  70                  75                  80  


Trp Glu Glu Ile His Val Pro Ser Asn Trp Gln Met Glu Gly Tyr Gly 
                85                  90                  95      


Arg Pro His Tyr Thr Asn Val Met Tyr Pro Phe Pro Val Asp Pro Pro 
            100                 105                 110         


Arg Val Pro Ser Glu Asn Pro Thr Gly Cys Tyr Arg Thr Lys Phe Phe 
        115                 120                 125             


Leu Thr His His Asp Val Gly Arg Val His Leu Arg Phe Glu Gly Val 
    130                 135                 140                 


Asp Gly Leu Tyr Gln Val Tyr Val Asn Gly His Asp Ile Gly Phe Gly 
145                 150                 155                 160 


Tyr Gly Ser Arg Leu Pro Ser Glu Phe Asp Ile Thr Asp Phe Val His 
                165                 170                 175     


Ala Gly Asp Asn Val Leu Val Val Val Val Cys Gln Trp Ser Ala Gln 
            180                 185                 190         


Ser Tyr Leu Glu Asp Gln Asp Met Trp Trp Leu Ser Gly Ile Phe Arg 
        195                 200                 205             


Asp Val Tyr Ile Leu Lys Arg Pro Gln Ile Tyr Leu Ser Asp Val Arg 
    210                 215                 220                 


Val Arg Ala Leu Leu Gly Thr Asp Gly Arg Thr Gly Cys Leu His Val 
225                 230                 235                 240 


Glu Val Glu Ile Gly Gly Ile Leu Ser Arg Asp Lys Pro Val Pro Leu 
                245                 250                 255     


Arg Phe Lys Leu Ile Asp Ser Ile Gly Asp Ser Glu Ile Leu Glu Asn 
            260                 265                 270         


Thr Met Leu Ser Asp Gly Phe Ala Thr Tyr Glu Ala Glu Ile Pro Asn 
        275                 280                 285             


Val Arg Pro Trp Thr Ala Glu Thr Pro Asn Leu Tyr Thr Leu Leu Val 
    290                 295                 300                 


Ser Ile Asp Pro Asp Ser Leu Tyr Ala Glu His Val Ala Leu Gln Val 
305                 310                 315                 320 


Gly Phe Arg Arg Ile Glu Ile Ala Asp Gly Gln Leu Lys Ile Asn Gly 
                325                 330                 335     


Val Pro Ile Val Leu Lys Gly Val Asn Arg His Glu His Asp Ala Arg 
            340                 345                 350         


Leu Gly Arg Ala Leu Thr Leu Asp Val Met Ile Arg Asp Val Gln Met 
        355                 360                 365             


Met Lys Gln Asn Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro His 
    370                 375                 380                 


His Pro Val Phe Tyr Asp Leu Cys Asp Arg Tyr Gly Leu Tyr Val Leu 
385                 390                 395                 400 


Asp Glu Ala Asp Leu Glu Cys His Gly Phe Ala Leu Thr Gly Asn Trp 
                405                 410                 415     


Asp Arg Leu Ser Asp Asp Pro Gln Leu Glu Gln Ala Tyr Val Asp Arg 
            420                 425                 430         


Leu Glu Arg Met Ile Cys Arg Asp Arg Asn His Ala Cys Val Ile Met 
        435                 440                 445             


Trp Ser Leu Gly Asn Glu Ser Gly Tyr Gly Arg Asn His Arg Ala Met 
    450                 455                 460                 


Ala Glu Arg Ala Arg Ala Ile Asp Pro Thr Arg Pro Val His Tyr Glu 
465                 470                 475                 480 


Gly Glu Thr Arg Arg Leu Leu Glu Leu Gly Ser Asp Leu Gln His Ala 
                485                 490                 495     


Val Met Asp Val Tyr Ser Thr Met Tyr Thr Ser Val Asp Glu Leu Ser 
            500                 505                 510         


Arg Leu Gly Glu Leu Glu Leu Pro Lys Pro His Ile Leu Cys Glu Phe 
        515                 520                 525             


Ala His Ala Met Gly Asn Gly Pro Gly Gly Leu Lys Glu Tyr Val Glu 
    530                 535                 540                 


Leu Phe Tyr Gln Gln Arg Arg Leu Gln Gly Gly Phe Val Trp Glu Trp 
545                 550                 555                 560 


Ile Asp His Gly Ile Leu Ala Tyr Thr Ser Asp Gly Arg Pro Tyr Phe 
                565                 570                 575     


Ala Tyr Gly Gly Asp Phe Gly Asp Val Pro Asn Asp Leu Asn Phe Val 
            580                 585                 590         


Ile Asp Gly Leu Leu Phe Pro Asp Arg Thr Pro Ser Pro Gly Leu Phe 
        595                 600                 605             


Glu Tyr Lys Lys Ala Ile Glu Pro Val Arg Val Leu Glu Phe Asp Arg 
    610                 615                 620                 


Ser Ser Gly Ile Ile Lys Val Gln Asn Arg Tyr Asp Phe Leu Cys Leu 
625                 630                 635                 640 


Asp Cys Leu Val Ala Glu Trp Ser Leu Gln Asp Glu Gln Ser Val Leu 
                645                 650                 655     


Ala Gly Gly Ile Leu Glu Leu Glu Pro Val Pro Pro Arg Ser Ile Gly 
            660                 665                 670         


Gln Ile Arg Val Pro Cys Ala Glu Ile Leu Asn Arg His Arg Asp Arg 
        675                 680                 685             


Cys Leu Thr Leu Thr Val Arg Phe Leu Leu Arg His Pro Thr Asp Tyr 
    690                 695                 700                 


Ala Pro Ala Phe His Glu Val Ala Ser Phe Cys Glu Tyr Val Glu Arg 
705                 710                 715                 720 


Ser Cys Gln Asn Ala Ser Ile Asp Ile Tyr Arg Pro Val Thr Arg Phe 
                725                 730                 735     


Glu Ile Val Glu Lys Gly Ser Ser Leu Cys Ile Tyr Asp Asp Ser Phe 
            740                 745                 750         


Ser Val Glu Phe Asp Leu Leu Arg Gly Arg Ile Ser Gly Val Gly Tyr 
        755                 760                 765             


Arg Gly Ser Gln Ile Ile Met Ser Pro Leu Ser Met Ser Phe Trp Arg 
    770                 775                 780                 


Ala Pro Thr Asp Asn Asp Asp Pro Pro Asn Arg Glu Met Phe Ser Val 
785                 790                 795                 800 


Ala Lys Val Trp Arg Asp Tyr Gly Val Asp Arg Leu Ser Glu Ser Val 
                805                 810                 815     


Ser Asn Ile Glu Ile Lys Lys His Asp Asn Val Val Arg Ala Leu Val 
            820                 825                 830         


Glu Ser Arg Val Ala Pro Ala Gly Leu Ser Trp Gly Met Ala Leu Gln 
        835                 840                 845             


Tyr Glu Tyr Ile Phe Leu Arg Gly Gly Leu Val Met Val Arg Ile Cys 
    850                 855                 860                 


Gly Lys Pro Glu Gly Ala Tyr Pro Pro Thr Leu Pro Arg Ile Gly Leu 
865                 870                 875                 880 


Leu Thr Thr Ile His Leu Asp Phe Glu Tyr Val Ser Trp Phe Gly Arg 
                885                 890                 895     


Gly Pro Gly Glu Ser Tyr Arg Asp Ser Lys Glu Ser Gln Leu Ile Gly 
            900                 905                 910         


Arg Tyr Arg Arg Leu Ala Asp Glu Leu Tyr Thr Pro Tyr Val Tyr Pro 
        915                 920                 925             


Gln Glu Asn Gly Asn Arg Thr Asp Val Tyr Trp Ile Ser Ile Thr Asn 
    930                 935                 940                 


Lys Tyr Met Glu Gly Leu Phe Ile Thr Gly Pro Gln Pro Leu Asn Phe 
945                 950                 955                 960 


Gln Val Ser Arg Phe Ser Val Glu Asp Leu Glu Arg Ala Arg His Pro 
                965                 970                 975     


Tyr Glu Leu Glu Glu Ser Pro Trp Arg Tyr Leu Arg Ile Asp Phe Ser 
            980                 985                 990         


His His Gly Leu Gly Ser Ala Ser  Cys Gly Pro Gly Pro  Leu Pro Glu 
        995                 1000                 1005             


His Gln  Leu Arg Thr Glu Pro  Phe Glu Trp Thr Leu  Cys Phe Ala 
    1010                 1015                 1020             


Pro Leu  Ala Arg His Glu Ile  Asp Glu Ser Ile Leu  His Gln Val 
    1025                 1030                 1035             


Val Thr  Glu Arg Leu Lys Phe  Ile 
    1040                 1045     


<210>  333
<211>  1046
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:321 and encoded by SEQ ID NO:328

<400>  333

Met Glu Val Met Arg Leu Glu Gln Lys Tyr Val Glu Ser Phe Tyr Pro 
1               5                   10                  15      


Pro Ser Asp Tyr Arg Leu Pro Pro Arg Ala Phe Phe Ile Pro His Ser 
            20                  25                  30          


Thr Glu Arg Glu Ala Leu Ala Arg Gly Phe Tyr Arg Ala Ser Thr Gln 
        35                  40                  45              


Val Leu Pro Leu Glu Gly Lys Trp Lys Phe Arg Leu Phe Asp Asn Pro 
    50                  55                  60                  


Arg Ala Val Pro Thr Asp Val Thr Trp Ile Asp Phe Asp Asp Ser Ser 
65                  70                  75                  80  


Trp Glu Glu Ile His Val Pro Ser Asn Trp Gln Met Glu Gly Tyr Gly 
                85                  90                  95      


Arg Pro His Tyr Thr Asn Val Met Tyr Pro Phe Pro Val Asp Pro Pro 
            100                 105                 110         


Arg Val Pro Ser Glu Asn Pro Thr Gly Cys Tyr Arg Thr Lys Phe Phe 
        115                 120                 125             


Leu Thr His His Asp Val Gly Arg Val His Leu Arg Phe Glu Gly Val 
    130                 135                 140                 


Asp Gly Leu Tyr Gln Val Tyr Val Asn Gly His Asp Ile Gly Phe Gly 
145                 150                 155                 160 


Tyr Gly Ser Arg Leu Pro Ser Glu Phe Asp Ile Thr Asp Phe Val His 
                165                 170                 175     


Ala Gly Asp Asn Val Leu Val Val Val Val Cys Gln Trp Ser Ala Gln 
            180                 185                 190         


Ser Tyr Leu Glu Asp Gln Asp Met Trp Trp Leu Ser Gly Ile Phe Arg 
        195                 200                 205             


Asp Val Tyr Ile Leu Lys Arg Pro Gln Ile Tyr Leu Ser Asp Val Arg 
    210                 215                 220                 


Val Arg Ala Leu Leu Gly Thr Asp Gly Arg Thr Gly Cys Leu His Val 
225                 230                 235                 240 


Glu Val Glu Ile Gly Gly Ile Leu Ser Arg Asp Lys Pro Val Pro Leu 
                245                 250                 255     


Arg Phe Lys Leu Ile Asp Ser Ile Gly Asp Ser Glu Ile Leu Glu Asn 
            260                 265                 270         


Thr Met Leu Ser Asp Gly Phe Ala Thr Tyr Glu Ala Glu Ile Pro Asn 
        275                 280                 285             


Val Arg Pro Trp Thr Ala Glu Thr Pro Asn Leu Tyr Thr Leu Leu Val 
    290                 295                 300                 


Ser Ile Asp Pro Asp Ser Leu Tyr Ala Glu His Val Ala Leu Gln Val 
305                 310                 315                 320 


Gly Phe Arg Arg Ile Glu Ile Ala Asp Gly Gln Leu Lys Ile Asn Gly 
                325                 330                 335     


Val Pro Ile Val Leu Lys Gly Val Asn Arg His Glu His Asp Ala Arg 
            340                 345                 350         


Leu Gly Arg Ala Leu Thr Leu Asp Val Met Ile Arg Asp Val Gln Met 
        355                 360                 365             


Met Lys Gln Asn Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro His 
    370                 375                 380                 


His Pro Val Phe Tyr Asp Leu Cys Asp Arg Tyr Gly Leu Tyr Val Leu 
385                 390                 395                 400 


Asp Glu Ala Asp Leu Glu Cys His Gly Phe Ala Leu Thr Gly Asn Trp 
                405                 410                 415     


Asp Arg Leu Ser Asp Asp Pro Gln Leu Glu Gln Ala Tyr Val Asp Arg 
            420                 425                 430         


Leu Glu Arg Met Ile Cys Arg Asp Arg Asn His Ala Cys Val Ile Met 
        435                 440                 445             


Trp Ser Leu Gly Asn Glu Ser Gly Tyr Gly Arg Asn His Arg Ala Met 
    450                 455                 460                 


Ala Glu Arg Ala Arg Ala Ile Asp Pro Thr Arg Pro Val His Tyr Glu 
465                 470                 475                 480 


Gly Glu Thr Arg Arg Leu Leu Glu Leu Gly Ser Asp Leu Gln His Ala 
                485                 490                 495     


Val Met Asp Val Tyr Ser Thr Met Tyr Thr Ser Val Asp Glu Leu Ser 
            500                 505                 510         


Arg Leu Gly Glu Leu Glu Leu Pro Lys Pro His Ile Leu Cys Glu Phe 
        515                 520                 525             


Ala His Ala Met Gly Asn Gly Pro Gly Gly Leu Lys Glu Tyr Val Glu 
    530                 535                 540                 


Leu Phe Tyr Gln Gln Arg Arg Leu Gln Gly Gly Phe Val Trp Glu Trp 
545                 550                 555                 560 


Ile Asp His Gly Ile Leu Ala Tyr Thr Ser Asp Gly Arg Pro Tyr Phe 
                565                 570                 575     


Ala Tyr Gly Gly Asp Phe Gly Asp Val Pro Asn Asp Leu Asn Phe Val 
            580                 585                 590         


Ile Asp Gly Leu Leu Phe Pro Asp Arg Thr Pro Ser Pro Gly Leu Phe 
        595                 600                 605             


Glu Tyr Lys Lys Ala Ile Glu Pro Val Arg Val Leu Glu Phe Asp Arg 
    610                 615                 620                 


Ser Ser Gly Ile Ile Lys Val Gln Asn Arg Tyr Asp Phe Leu Cys Leu 
625                 630                 635                 640 


Asp Cys Leu Val Ala Glu Trp Ser Leu Gln Asp Glu Gln Ser Val Leu 
                645                 650                 655     


Ala Gly Gly Ile Leu Glu Leu Glu Pro Val Pro Pro Arg Ser Ile Gly 
            660                 665                 670         


Gln Ile Arg Val Pro Cys Ala Glu Ile Leu Asn Arg His Arg Asp Arg 
        675                 680                 685             


Cys Leu Thr Leu Thr Val Arg Phe Leu Leu Arg His Pro Thr Asp Tyr 
    690                 695                 700                 


Ala Pro Ala Phe His Glu Val Ala Ser Phe Cys Glu Tyr Val Glu Arg 
705                 710                 715                 720 


Ser Cys Gln Asn Ala Ser Ile Asp Ile Tyr Arg Pro Val Thr Arg Phe 
                725                 730                 735     


Glu Ile Val Glu Lys Gly Ser Ser Leu Cys Ile Tyr Asp Asp Ser Phe 
            740                 745                 750         


Ser Val Glu Phe Asp Leu Leu Arg Gly Arg Ile Ser Gly Val Gly Tyr 
        755                 760                 765             


Arg Gly Ser Gln Ile Ile Met Ser Pro Leu Ser Met Ser Phe Trp Arg 
    770                 775                 780                 


Ala Pro Thr Asp Asn Asp Asp Pro Pro Asn Arg Glu Met Phe Ser Val 
785                 790                 795                 800 


Ala Lys Val Trp Arg Asp Tyr Gly Val Asp Arg Leu Ser Glu Ser Val 
                805                 810                 815     


Ser Asn Ile Glu Ile Lys Lys His Asp Asn Val Val Arg Ala Leu Val 
            820                 825                 830         


Glu Ser Arg Val Ala Pro Ala Gly Leu Ser Trp Gly Met Ala Leu Gln 
        835                 840                 845             


Tyr Glu Tyr Ile Phe Leu Arg Gly Gly Leu Val Met Val Arg Ile Cys 
    850                 855                 860                 


Gly Lys Pro Glu Gly Ala Tyr Pro Pro Thr Leu Pro Arg Ile Gly Leu 
865                 870                 875                 880 


Leu Thr Thr Ile His Leu Asp Phe Glu Tyr Val Ser Trp Phe Gly Arg 
                885                 890                 895     


Gly Pro Gly Glu Ser Tyr Arg Asp Ser Lys Glu Ser Gln Leu Ile Gly 
            900                 905                 910         


Arg Tyr Arg Arg Leu Ala Asp Glu Leu Tyr Thr Pro Tyr Val Tyr Pro 
        915                 920                 925             


Gln Glu Asn Gly Asn Arg Thr Asp Val Tyr Trp Ile Ser Ile Thr Asn 
    930                 935                 940                 


Lys Tyr Met Glu Gly Leu Phe Ile Thr Gly Pro Gln Pro Leu Asn Phe 
945                 950                 955                 960 


Gln Val Ser Arg Phe Ser Val Glu Asp Leu Glu Arg Ala Arg His Pro 
                965                 970                 975     


Tyr Glu Leu Glu Glu Ser Pro Trp Arg Tyr Leu Arg Ile Asp Phe Ser 
            980                 985                 990         


His His Gly Leu Gly Ser Ala Ser  Cys Gly Pro Gly Pro  Leu Pro Glu 
        995                 1000                 1005             


His Gln  Leu Arg Thr Glu Pro  Phe Glu Trp Thr Leu  Cys Phe Ala 
    1010                 1015                 1020             


Pro Leu  Ala Arg His Glu Ile  Asp Glu Ser Ile Leu  His Gln Val 
    1025                 1030                 1035             


Val Thr  Glu Arg Leu Lys Phe  Ile 
    1040                 1045     


<210>  334
<211>  1046
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:321 and encoded by SEQ ID NO:329

<400>  334

Met Glu Val Met Arg Val Glu Asn Lys Tyr Val Glu Ser Phe Tyr Pro 
1               5                   10                  15      


Pro Ser Asp Tyr Arg Leu Pro Pro Arg Ala Phe Phe Ile Pro His Ser 
            20                  25                  30          


Thr Glu Arg Glu Ala Leu Ala Arg Gly Phe Tyr Arg Ala Ser Thr Gln 
        35                  40                  45              


Val Leu Pro Leu Glu Gly Lys Trp Lys Phe Arg Leu Phe Asp Asn Pro 
    50                  55                  60                  


Arg Ala Val Pro Thr Asp Val Thr Trp Ile Asp Phe Asp Asp Ser Ser 
65                  70                  75                  80  


Trp Glu Glu Ile His Val Pro Ser Asn Trp Gln Met Glu Gly Tyr Gly 
                85                  90                  95      


Arg Pro His Tyr Thr Asn Val Met Tyr Pro Phe Pro Val Asp Pro Pro 
            100                 105                 110         


Arg Val Pro Ser Glu Asn Pro Thr Gly Cys Tyr Arg Thr Lys Phe Phe 
        115                 120                 125             


Leu Thr His His Asp Val Gly Arg Val His Leu Arg Phe Glu Gly Val 
    130                 135                 140                 


Asp Gly Leu Tyr Gln Val Tyr Val Asn Gly His Asp Ile Gly Phe Gly 
145                 150                 155                 160 


Tyr Gly Ser Arg Leu Pro Ser Glu Phe Asp Ile Thr Asp Phe Val His 
                165                 170                 175     


Ala Gly Asp Asn Val Leu Val Val Val Val Cys Gln Trp Ser Ala Gln 
            180                 185                 190         


Ser Tyr Leu Glu Asp Gln Asp Met Trp Trp Leu Ser Gly Ile Phe Arg 
        195                 200                 205             


Asp Val Tyr Ile Leu Lys Arg Pro Gln Ile Tyr Leu Ser Asp Val Arg 
    210                 215                 220                 


Val Arg Ala Leu Leu Gly Thr Asp Gly Arg Thr Gly Cys Leu His Val 
225                 230                 235                 240 


Glu Val Glu Ile Gly Gly Ile Leu Ser Arg Asp Lys Pro Val Pro Leu 
                245                 250                 255     


Arg Phe Lys Leu Ile Asp Ser Ile Gly Asp Ser Glu Ile Leu Glu Asn 
            260                 265                 270         


Thr Met Leu Ser Asp Gly Phe Ala Thr Tyr Glu Ala Glu Ile Pro Asn 
        275                 280                 285             


Val Arg Pro Trp Thr Ala Glu Thr Pro Asn Leu Tyr Thr Leu Leu Val 
    290                 295                 300                 


Ser Ile Asp Pro Asp Ser Leu Tyr Ala Glu His Val Ala Leu Gln Val 
305                 310                 315                 320 


Gly Phe Arg Arg Ile Glu Ile Ala Asp Gly Gln Leu Lys Ile Asn Gly 
                325                 330                 335     


Val Pro Ile Val Leu Lys Gly Val Asn Arg His Glu His Asp Ala Arg 
            340                 345                 350         


Leu Gly Arg Ala Leu Thr Leu Asp Val Met Ile Arg Asp Val Gln Met 
        355                 360                 365             


Met Lys Gln Asn Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro His 
    370                 375                 380                 


His Pro Val Phe Tyr Asp Leu Cys Asp Arg Tyr Gly Leu Tyr Val Leu 
385                 390                 395                 400 


Asp Glu Ala Asp Leu Glu Cys His Gly Phe Ala Leu Thr Gly Asn Trp 
                405                 410                 415     


Asp Arg Leu Ser Asp Asp Pro Gln Leu Glu Gln Ala Tyr Val Asp Arg 
            420                 425                 430         


Leu Glu Arg Met Ile Cys Arg Asp Arg Asn His Ala Cys Val Ile Met 
        435                 440                 445             


Trp Ser Leu Gly Asn Glu Ser Gly Tyr Gly Arg Asn His Arg Ala Met 
    450                 455                 460                 


Ala Glu Arg Ala Arg Ala Ile Asp Pro Thr Arg Pro Val His Tyr Glu 
465                 470                 475                 480 


Gly Glu Thr Arg Arg Leu Leu Glu Leu Gly Ser Asp Leu Gln His Ala 
                485                 490                 495     


Val Met Asp Val Tyr Ser Thr Met Tyr Thr Ser Val Asp Glu Leu Ser 
            500                 505                 510         


Arg Leu Gly Glu Leu Glu Leu Pro Lys Pro His Ile Leu Cys Glu Phe 
        515                 520                 525             


Ala His Ala Met Gly Asn Gly Pro Gly Gly Leu Lys Glu Tyr Val Glu 
    530                 535                 540                 


Leu Phe Tyr Gln Gln Arg Arg Leu Gln Gly Gly Phe Val Trp Glu Trp 
545                 550                 555                 560 


Ile Asp His Gly Ile Leu Ala Tyr Thr Ser Asp Gly Arg Pro Tyr Phe 
                565                 570                 575     


Ala Tyr Gly Gly Asp Phe Gly Asp Val Pro Asn Asp Leu Asn Phe Val 
            580                 585                 590         


Ile Asp Gly Leu Leu Phe Pro Asp Arg Thr Pro Ser Pro Gly Leu Phe 
        595                 600                 605             


Glu Tyr Lys Lys Ala Ile Glu Pro Val Arg Val Leu Glu Phe Asp Arg 
    610                 615                 620                 


Ser Ser Gly Ile Ile Lys Val Gln Asn Arg Tyr Asp Phe Leu Cys Leu 
625                 630                 635                 640 


Asp Cys Leu Val Ala Glu Trp Ser Leu Gln Asp Glu Gln Ser Val Leu 
                645                 650                 655     


Ala Gly Gly Ile Leu Glu Leu Glu Pro Val Pro Pro Arg Ser Ile Gly 
            660                 665                 670         


Gln Ile Arg Val Pro Cys Ala Glu Ile Leu Asn Arg His Arg Asp Arg 
        675                 680                 685             


Cys Leu Thr Leu Thr Val Arg Phe Leu Leu Arg His Pro Thr Asp Tyr 
    690                 695                 700                 


Ala Pro Ala Phe His Glu Val Ala Ser Phe Cys Glu Tyr Val Glu Arg 
705                 710                 715                 720 


Ser Cys Gln Asn Ala Ser Ile Asp Ile Tyr Arg Pro Val Thr Arg Phe 
                725                 730                 735     


Glu Ile Val Glu Lys Gly Ser Ser Leu Cys Ile Tyr Asp Asp Ser Phe 
            740                 745                 750         


Ser Val Glu Phe Asp Leu Leu Arg Gly Arg Ile Ser Gly Val Gly Tyr 
        755                 760                 765             


Arg Gly Ser Gln Ile Ile Met Ser Pro Leu Ser Met Ser Phe Trp Arg 
    770                 775                 780                 


Ala Pro Thr Asp Asn Asp Asp Pro Pro Asn Arg Glu Met Phe Ser Val 
785                 790                 795                 800 


Ala Lys Val Trp Arg Asp Tyr Gly Val Asp Arg Leu Ser Glu Ser Val 
                805                 810                 815     


Ser Asn Ile Glu Ile Lys Lys His Asp Asn Val Val Arg Ala Leu Val 
            820                 825                 830         


Glu Ser Arg Val Ala Pro Ala Gly Leu Ser Trp Gly Met Ala Leu Gln 
        835                 840                 845             


Tyr Glu Tyr Ile Phe Leu Arg Gly Gly Leu Val Met Val Arg Ile Cys 
    850                 855                 860                 


Gly Lys Pro Glu Gly Ala Tyr Pro Pro Thr Leu Pro Arg Ile Gly Leu 
865                 870                 875                 880 


Leu Thr Thr Ile His Leu Asp Phe Glu Tyr Val Ser Trp Phe Gly Arg 
                885                 890                 895     


Gly Pro Gly Glu Ser Tyr Arg Asp Ser Lys Glu Ser Gln Leu Ile Gly 
            900                 905                 910         


Arg Tyr Arg Arg Leu Ala Asp Glu Leu Tyr Thr Pro Tyr Val Tyr Pro 
        915                 920                 925             


Gln Glu Asn Gly Asn Arg Thr Asp Val Tyr Trp Ile Ser Ile Thr Asn 
    930                 935                 940                 


Lys Tyr Met Glu Gly Leu Phe Ile Thr Gly Pro Gln Pro Leu Asn Phe 
945                 950                 955                 960 


Gln Val Ser Arg Phe Ser Val Glu Asp Leu Glu Arg Ala Arg His Pro 
                965                 970                 975     


Tyr Glu Leu Glu Glu Ser Pro Trp Arg Tyr Leu Arg Ile Asp Phe Ser 
            980                 985                 990         


His His Gly Leu Gly Ser Ala Ser  Cys Gly Pro Gly Pro  Leu Pro Glu 
        995                 1000                 1005             


His Gln  Leu Arg Thr Glu Pro  Phe Glu Trp Thr Leu  Cys Phe Ala 
    1010                 1015                 1020             


Pro Leu  Ala Arg His Glu Ile  Asp Glu Ser Ile Leu  His Gln Val 
    1025                 1030                 1035             


Val Thr  Glu Arg Leu Lys Phe  Ile 
    1040                 1045     


<210>  335
<211>  1046
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:321 and encoded by SEQ ID NO:326

<400>  335

Met Glu Val Met Arg Val Glu Gln Arg Tyr Val Glu Ser Phe Tyr Pro 
1               5                   10                  15      


Pro Ser Asp Tyr Arg Leu Pro Pro Arg Ala Phe Phe Ile Pro His Ser 
            20                  25                  30          


Thr Glu Arg Glu Ala Leu Ala Arg Gly Phe Tyr Arg Ala Ser Thr Gln 
        35                  40                  45              


Val Leu Pro Leu Glu Gly Lys Trp Lys Phe Arg Leu Phe Asp Asn Pro 
    50                  55                  60                  


Arg Ala Val Pro Thr Asp Val Thr Trp Ile Asp Phe Asp Asp Ser Ser 
65                  70                  75                  80  


Trp Glu Glu Ile His Val Pro Ser Asn Trp Gln Met Glu Gly Tyr Gly 
                85                  90                  95      


Arg Pro His Tyr Thr Asn Val Met Tyr Pro Phe Pro Val Asp Pro Pro 
            100                 105                 110         


Arg Val Pro Ser Glu Asn Pro Thr Gly Cys Tyr Arg Thr Lys Phe Phe 
        115                 120                 125             


Leu Thr His His Asp Val Gly Arg Val His Leu Arg Phe Glu Gly Val 
    130                 135                 140                 


Asp Gly Leu Tyr Gln Val Tyr Val Asn Gly His Asp Ile Gly Phe Gly 
145                 150                 155                 160 


Tyr Gly Ser Arg Leu Pro Ser Glu Phe Asp Ile Thr Asp Phe Val His 
                165                 170                 175     


Ala Gly Asp Asn Val Leu Val Val Val Val Cys Gln Trp Ser Ala Gln 
            180                 185                 190         


Ser Tyr Leu Glu Asp Gln Asp Met Trp Trp Leu Ser Gly Ile Phe Arg 
        195                 200                 205             


Asp Val Tyr Ile Leu Lys Arg Pro Gln Ile Tyr Leu Ser Asp Val Arg 
    210                 215                 220                 


Val Arg Ala Leu Leu Gly Thr Asp Gly Arg Thr Gly Cys Leu His Val 
225                 230                 235                 240 


Glu Val Glu Ile Gly Gly Ile Leu Ser Arg Asp Lys Pro Val Pro Leu 
                245                 250                 255     


Arg Phe Lys Leu Ile Asp Ser Ile Gly Asp Ser Glu Ile Leu Glu Asn 
            260                 265                 270         


Thr Met Leu Ser Asp Gly Phe Ala Thr Tyr Glu Ala Glu Ile Pro Asn 
        275                 280                 285             


Val Arg Pro Trp Thr Ala Glu Thr Pro Asn Leu Tyr Thr Leu Leu Val 
    290                 295                 300                 


Ser Ile Asp Pro Asp Ser Leu Tyr Ala Glu His Val Ala Leu Gln Val 
305                 310                 315                 320 


Gly Phe Arg Arg Ile Glu Ile Ala Asp Gly Gln Leu Lys Ile Asn Gly 
                325                 330                 335     


Val Pro Ile Val Leu Lys Gly Val Asn Arg His Glu His Asp Ala Arg 
            340                 345                 350         


Leu Gly Arg Ala Leu Thr Leu Asp Val Met Ile Arg Asp Val Gln Met 
        355                 360                 365             


Met Lys Gln Asn Asn Ile Asn Ala Val Arg Thr Ser His Tyr Pro His 
    370                 375                 380                 


His Pro Val Phe Tyr Asp Leu Cys Asp Arg Tyr Gly Leu Tyr Val Leu 
385                 390                 395                 400 


Asp Glu Ala Asp Leu Glu Cys His Gly Phe Ala Leu Thr Gly Asn Trp 
                405                 410                 415     


Asp Arg Leu Ser Asp Asp Pro Gln Leu Glu Gln Ala Tyr Val Asp Arg 
            420                 425                 430         


Leu Glu Arg Met Ile Cys Arg Asp Arg Asn His Ala Cys Val Ile Met 
        435                 440                 445             


Trp Ser Leu Gly Asn Glu Ser Gly Tyr Gly Arg Asn His Arg Ala Met 
    450                 455                 460                 


Ala Glu Arg Ala Arg Ala Ile Asp Pro Thr Arg Pro Val His Tyr Glu 
465                 470                 475                 480 


Gly Glu Thr Arg Arg Leu Leu Glu Leu Gly Ser Asp Leu Gln His Ala 
                485                 490                 495     


Val Met Asp Val Tyr Ser Thr Met Tyr Thr Ser Val Asp Glu Leu Ser 
            500                 505                 510         


Arg Leu Gly Glu Leu Glu Leu Pro Lys Pro His Ile Leu Cys Glu Phe 
        515                 520                 525             


Ala His Ala Met Gly Asn Gly Pro Gly Gly Leu Lys Glu Tyr Val Glu 
    530                 535                 540                 


Leu Phe Tyr Gln Gln Arg Arg Leu Gln Gly Gly Phe Val Trp Glu Trp 
545                 550                 555                 560 


Ile Asp His Gly Ile Leu Ala Tyr Thr Ser Asp Gly Arg Pro Tyr Phe 
                565                 570                 575     


Ala Tyr Gly Gly Asp Phe Gly Asp Val Pro Asn Asp Leu Asn Phe Val 
            580                 585                 590         


Ile Asp Gly Leu Leu Phe Pro Asp Arg Thr Pro Ser Pro Gly Leu Phe 
        595                 600                 605             


Glu Tyr Lys Lys Ala Ile Glu Pro Val Arg Val Leu Glu Phe Asp Arg 
    610                 615                 620                 


Ser Ser Gly Ile Ile Lys Val Gln Asn Arg Tyr Asp Phe Leu Cys Leu 
625                 630                 635                 640 


Asp Cys Leu Val Ala Glu Trp Ser Leu Gln Asp Glu Gln Ser Val Leu 
                645                 650                 655     


Ala Gly Gly Ile Leu Glu Leu Glu Pro Val Pro Pro Arg Ser Ile Gly 
            660                 665                 670         


Gln Ile Arg Val Pro Cys Ala Glu Ile Leu Asn Arg His Arg Asp Arg 
        675                 680                 685             


Cys Leu Thr Leu Thr Val Arg Phe Leu Leu Arg His Pro Thr Asp Tyr 
    690                 695                 700                 


Ala Pro Ala Phe His Glu Val Ala Ser Phe Cys Glu Tyr Val Glu Arg 
705                 710                 715                 720 


Ser Cys Gln Asn Ala Ser Ile Asp Ile Tyr Arg Pro Val Thr Arg Phe 
                725                 730                 735     


Glu Ile Val Glu Lys Gly Ser Ser Leu Cys Ile Tyr Asp Asp Ser Phe 
            740                 745                 750         


Ser Val Glu Phe Asp Leu Leu Arg Gly Arg Ile Ser Gly Val Gly Tyr 
        755                 760                 765             


Arg Gly Ser Gln Ile Ile Met Ser Pro Leu Ser Met Ser Phe Trp Arg 
    770                 775                 780                 


Ala Pro Thr Asp Asn Asp Asp Pro Pro Asn Arg Glu Met Phe Ser Val 
785                 790                 795                 800 


Ala Lys Val Trp Arg Asp Tyr Gly Val Asp Arg Leu Ser Glu Ser Val 
                805                 810                 815     


Ser Asn Ile Glu Ile Lys Lys His Asp Asn Val Val Arg Ala Leu Val 
            820                 825                 830         


Glu Ser Arg Val Ala Pro Ala Gly Leu Ser Trp Gly Met Ala Leu Gln 
        835                 840                 845             


Tyr Glu Tyr Ile Phe Leu Arg Gly Gly Leu Val Met Val Arg Ile Cys 
    850                 855                 860                 


Gly Lys Pro Glu Gly Ala Tyr Pro Pro Thr Leu Pro Arg Ile Gly Leu 
865                 870                 875                 880 


Leu Thr Thr Ile His Leu Asp Phe Glu Tyr Val Ser Trp Phe Gly Arg 
                885                 890                 895     


Gly Pro Gly Glu Ser Tyr Arg Asp Ser Lys Glu Ser Gln Leu Ile Gly 
            900                 905                 910         


Arg Tyr Arg Arg Leu Ala Asp Glu Leu Tyr Thr Pro Tyr Val Tyr Pro 
        915                 920                 925             


Gln Glu Asn Gly Asn Arg Thr Asp Val Tyr Trp Ile Ser Ile Thr Asn 
    930                 935                 940                 


Lys Tyr Met Glu Gly Leu Phe Ile Thr Gly Pro Gln Pro Leu Asn Phe 
945                 950                 955                 960 


Gln Val Ser Arg Phe Ser Val Glu Asp Leu Glu Arg Ala Arg His Pro 
                965                 970                 975     


Tyr Glu Leu Glu Glu Ser Pro Trp Arg Tyr Leu Arg Ile Asp Phe Ser 
            980                 985                 990         


His His Gly Leu Gly Ser Ala Ser  Cys Gly Pro Gly Pro  Leu Pro Glu 
        995                 1000                 1005             


His Gln  Leu Arg Thr Glu Pro  Phe Glu Trp Thr Leu  Cys Phe Ala 
    1010                 1015                 1020             


Pro Leu  Ala Arg His Glu Ile  Asp Glu Ser Ile Leu  His Gln Val 
    1025                 1030                 1035             


Val Thr  Glu Arg Leu Lys Phe  Ile 
    1040                 1045     


<210>  336
<211>  2073
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  336
ttgacgaaca tccctgaggg cgatctcgac taccgcgctt ggttgcagga gagcccgctg     60

ccccgcgccg tgccggaagc ggcgcggcgg atggcggtgt acggcccggc ggatgatccg    120

ctcctttgca ccgcggcggc ggagtggggg cgcgcggtcc gcgcggcgtg cggggaaagc    180

ccggcgcgct tggcgagaga cccgggcggt gcgccgagtg tgccttgcgt cgccatgggg    240

ctattgtcgg cgatgccacg cgggcttcgc gaggccgcgc aggctgcgct cgccggcgcg    300

ccttcggacg aggcctacgc catcttgccg gtggatgggc aaggcgtcgc agtcgtctcg    360

cggacgcccg ccggtgtgct gtacggcgtg ttccacctca tccgccgcct gcggctcggc    420

gaaccgctcc acgagccttg cgtctcctca cccaagaacg cctggcggat gctggatcac    480

tgggacaacg ccgacggcac gattgagcgc gggtacgcgg ggaaatcgct gttttaccgc    540

ggtggtcaaa tcgattttga cgaggggcgc gtacgggatt acgcgcggct tttggcgtct    600

gtcggcgtga acgccatcgc catcaacaac gtcaacgtgc acgagaccga gacgcgcttc    660

ctcaccgagg cgcatctgcc gggcgtcgcg cggctggccg acgtgtttcg cccgtacggc    720

atccgggtgt tcctcagcat caacttcgcg agccccgtcg atctcggcga cctgccgacc    780

gcggatccgc tcgatccgcg cgttgaggac tggtggcgcg cgacggcgga tcgcatctac    840

cggcacatcc cggacttcgg cggcttcctc gtgaaagcgg actccgagtt ccggcccggt    900

cccttcacct acgggcgcga tcatgccgac ggcgcgaaca tgctcgcccg agcgctggcg    960

cctcacggcg gcgtggtcat ctggcgggcc ttcgtgtaca actgcctcat ggactggcgg   1020

gaccggcgcg ccgaccgcgc ccgggcggcg tacgatcact tcgtgccgct cgacggccgc   1080

ttcctggaca acgtcctgat tcagatcaag aacgggccga tggactttca ggtgcgcgag   1140

ccggtctcgc cgctcttcgg cgggctttct gcgacgaacg tgatgctcga gttccagatc   1200

acgcaggagt acaccggcca gcagcgccac gtgtgctatc tcgcgccgat gtggaaagag   1260

gtgctcgact tcgacacgca cgcgcgcggg ccgggatcga cggtggccga gatcgcgagc   1320

ggcaggttgt tcgggcggcc gcacggcggc gtggcgggcg tcgcgaacgt gggcgacgat   1380

gtcaactgga cggggcactc gctggcgcag gcgaacctgt acgcgttcgg ccgactcgct   1440

tgggatccgt cgctcgatcc cgccgggatc gcgcgggagt gggcgcggct cacgtacggc   1500

gacgatccgg atgtcgtccg cacggtggtg ggcatcctca tggcctcctg gccggcgtac   1560

gaggcgtaca ccgcgccgct cggcgtgggc tggatggtga accccggcca ccacgacggg   1620

cccaatccgg agggctacga gtactcaaaa tggggcacgt accactacgc ggattggcga   1680

ggtgtcggcg tggatcggac gatggccacg ggcacgggct acaccggcca gtaccacgag   1740

ccgatgcgaa gcctgtacga gcacctggag acgtgccccg acgagcttct cctcttcttc   1800

catcatgtgc cgtacacgca cgtgctccac tccgggaaga cggtcattca gcacatctac   1860

gacgcgcact tcgacggcgt cgaggcggtg gcctggatga tcgaggcgtg gcggcggctt   1920

caggggcgga tcgatcccgt ccgcttcgag cgcgtcctcg cgcggctcga ggatcagatg   1980

cagcgcgccg tcgagtggcg ggacgtgatc aacacgtact tttatcgaaa gtgtggcatt   2040

cccgacgcac gggggctcca catctacccg tga                                2073


<210>  337
<211>  690
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  337

Met Thr Asn Ile Pro Glu Gly Asp Leu Asp Tyr Arg Ala Trp Leu Gln 
1               5                   10                  15      


Glu Ser Pro Leu Pro Arg Ala Val Pro Glu Ala Ala Arg Arg Met Ala 
            20                  25                  30          


Val Tyr Gly Pro Ala Asp Asp Pro Leu Leu Cys Thr Ala Ala Ala Glu 
        35                  40                  45              


Trp Gly Arg Ala Val Arg Ala Ala Cys Gly Glu Ser Pro Ala Arg Leu 
    50                  55                  60                  


Ala Arg Asp Pro Gly Gly Ala Pro Ser Val Pro Cys Val Ala Met Gly 
65                  70                  75                  80  


Leu Leu Ser Ala Met Pro Arg Gly Leu Arg Glu Ala Ala Gln Ala Ala 
                85                  90                  95      


Leu Ala Gly Ala Pro Ser Asp Glu Ala Tyr Ala Ile Leu Pro Val Asp 
            100                 105                 110         


Gly Gln Gly Val Ala Val Val Ser Arg Thr Pro Ala Gly Val Leu Tyr 
        115                 120                 125             


Gly Val Phe His Leu Ile Arg Arg Leu Arg Leu Gly Glu Pro Leu His 
    130                 135                 140                 


Glu Pro Cys Val Ser Ser Pro Lys Asn Ala Trp Arg Met Leu Asp His 
145                 150                 155                 160 


Trp Asp Asn Ala Asp Gly Thr Ile Glu Arg Gly Tyr Ala Gly Lys Ser 
                165                 170                 175     


Leu Phe Tyr Arg Gly Gly Gln Ile Asp Phe Asp Glu Gly Arg Val Arg 
            180                 185                 190         


Asp Tyr Ala Arg Leu Leu Ala Ser Val Gly Val Asn Ala Ile Ala Ile 
        195                 200                 205             


Asn Asn Val Asn Val His Glu Thr Glu Thr Arg Phe Leu Thr Glu Ala 
    210                 215                 220                 


His Leu Pro Gly Val Ala Arg Leu Ala Asp Val Phe Arg Pro Tyr Gly 
225                 230                 235                 240 


Ile Arg Val Phe Leu Ser Ile Asn Phe Ala Ser Pro Val Asp Leu Gly 
                245                 250                 255     


Asp Leu Pro Thr Ala Asp Pro Leu Asp Pro Arg Val Glu Asp Trp Trp 
            260                 265                 270         


Arg Ala Thr Ala Asp Arg Ile Tyr Arg His Ile Pro Asp Phe Gly Gly 
        275                 280                 285             


Phe Leu Val Lys Ala Asp Ser Glu Phe Arg Pro Gly Pro Phe Thr Tyr 
    290                 295                 300                 


Gly Arg Asp His Ala Asp Gly Ala Asn Met Leu Ala Arg Ala Leu Ala 
305                 310                 315                 320 


Pro His Gly Gly Val Val Ile Trp Arg Ala Phe Val Tyr Asn Cys Leu 
                325                 330                 335     


Met Asp Trp Arg Asp Arg Arg Ala Asp Arg Ala Arg Ala Ala Tyr Asp 
            340                 345                 350         


His Phe Val Pro Leu Asp Gly Arg Phe Leu Asp Asn Val Leu Ile Gln 
        355                 360                 365             


Ile Lys Asn Gly Pro Met Asp Phe Gln Val Arg Glu Pro Val Ser Pro 
    370                 375                 380                 


Leu Phe Gly Gly Leu Ser Ala Thr Asn Val Met Leu Glu Phe Gln Ile 
385                 390                 395                 400 


Thr Gln Glu Tyr Thr Gly Gln Gln Arg His Val Cys Tyr Leu Ala Pro 
                405                 410                 415     


Met Trp Lys Glu Val Leu Asp Phe Asp Thr His Ala Arg Gly Pro Gly 
            420                 425                 430         


Ser Thr Val Ala Glu Ile Ala Ser Gly Arg Leu Phe Gly Arg Pro His 
        435                 440                 445             


Gly Gly Val Ala Gly Val Ala Asn Val Gly Asp Asp Val Asn Trp Thr 
    450                 455                 460                 


Gly His Ser Leu Ala Gln Ala Asn Leu Tyr Ala Phe Gly Arg Leu Ala 
465                 470                 475                 480 


Trp Asp Pro Ser Leu Asp Pro Ala Gly Ile Ala Arg Glu Trp Ala Arg 
                485                 490                 495     


Leu Thr Tyr Gly Asp Asp Pro Asp Val Val Arg Thr Val Val Gly Ile 
            500                 505                 510         


Leu Met Ala Ser Trp Pro Ala Tyr Glu Ala Tyr Thr Ala Pro Leu Gly 
        515                 520                 525             


Val Gly Trp Met Val Asn Pro Gly His His Asp Gly Pro Asn Pro Glu 
    530                 535                 540                 


Gly Tyr Glu Tyr Ser Lys Trp Gly Thr Tyr His Tyr Ala Asp Trp Arg 
545                 550                 555                 560 


Gly Val Gly Val Asp Arg Thr Met Ala Thr Gly Thr Gly Tyr Thr Gly 
                565                 570                 575     


Gln Tyr His Glu Pro Met Arg Ser Leu Tyr Glu His Leu Glu Thr Cys 
            580                 585                 590         


Pro Asp Glu Leu Leu Leu Phe Phe His His Val Pro Tyr Thr His Val 
        595                 600                 605             


Leu His Ser Gly Lys Thr Val Ile Gln His Ile Tyr Asp Ala His Phe 
    610                 615                 620                 


Asp Gly Val Glu Ala Val Ala Trp Met Ile Glu Ala Trp Arg Arg Leu 
625                 630                 635                 640 


Gln Gly Arg Ile Asp Pro Val Arg Phe Glu Arg Val Leu Ala Arg Leu 
                645                 650                 655     


Glu Asp Gln Met Gln Arg Ala Val Glu Trp Arg Asp Val Ile Asn Thr 
            660                 665                 670         


Tyr Phe Tyr Arg Lys Cys Gly Ile Pro Asp Ala Arg Gly Leu His Ile 
        675                 680                 685             


Tyr Pro 
    690 


<210>  338
<211>  682
<212>  PRT
<213>  Bacillus halodurans

<400>  338

Met Asn Arg Gly Glu Thr Gly Tyr Glu Thr Trp Leu Arg Tyr Glu Glu 
1               5                   10                  15      


Ile Thr Asp Ser Ala Leu His Thr Gln Tyr Arg Ala Tyr Phe Gln Thr 
            20                  25                  30          


Ile Glu Ile Lys Gly Asn Ser Pro Ile Ile Glu Ser Ala Lys Glu Glu 
        35                  40                  45              


Leu Met Gln Gly Leu Arg Ser Leu Leu Gly Val Thr Pro Lys Cys Leu 
    50                  55                  60                  


Ser Ala Thr Gly Glu Gln Ala Ser Cys Leu Ile Gly Thr Ile Ala Asp 
65                  70                  75                  80  


Val Ala Glu Val Ser Gln Ala Ile Lys Glu Arg Leu Arg Glu Glu Gly 
                85                  90                  95      


Tyr Ala Ile Tyr Ser Glu Lys Gly Arg Leu Val Leu Val Gly Lys Thr 
            100                 105                 110         


Glu Thr Gly Val Leu Tyr Gly Thr Phe His Leu Leu Arg Leu Leu Gln 
        115                 120                 125             


Met Arg Asp His Leu His Asp Leu Arg Ile Val Glu Asn Pro Arg Asn 
    130                 135                 140                 


Gln Leu Arg Met Ile Asn Glu Trp Asp Asn Met Asp Gly Ser Ile Glu 
145                 150                 155                 160 


Arg Gly Tyr Ala Gly Gly Ser Ile Phe Phe Glu His Asn Lys Val Thr 
                165                 170                 175     


Asn Asn Leu Gln Arg Ile Lys Asp Tyr Ala Arg Ile Leu Ser Ser Ile 
            180                 185                 190         


Gly Ile Asn Ala Ile Ala Phe Asn Asn Val Asn Val His Glu Glu Glu 
        195                 200                 205             


Thr Lys Leu Ile Thr Arg Lys Phe Leu Pro Asp Val Ala Lys Val Ala 
    210                 215                 220                 


Asn Ile Phe Arg Gln Tyr Gly Ile Lys Thr Phe Leu Ser Ile Asn Tyr 
225                 230                 235                 240 


Ala Ser Pro Ile Gln Leu Gly Lys Leu Glu Thr Ala Asp Pro Leu Asp 
                245                 250                 255     


Glu Lys Val Arg Ala Trp Trp Lys Glu Thr Val Ala Asp Ile Tyr Arg 
            260                 265                 270         


Tyr Ile Pro Asp Phe Gly Gly Phe Leu Val Lys Ala Asp Ser Glu His 
        275                 280                 285             


Arg Pro Gly Pro Phe Thr Tyr Gly Arg Asn His Ala Glu Gly Ala Asn 
    290                 295                 300                 


Met Leu Ala Glu Ala Leu Ala Pro Phe Gly Gly Ile Val Leu Trp Arg 
305                 310                 315                 320 


Cys Phe Val Tyr Asn Cys Leu Gln Asp Trp Arg Asp Arg Lys Thr Asp 
                325                 330                 335     


Arg Ala Arg Ala Ala Tyr Asp His Phe Lys Pro Leu Asp Gly Leu Phe 
            340                 345                 350         


His Asp Asn Val Val Leu Gln Ile Lys Asn Gly Pro Met Asp Phe Gln 
        355                 360                 365             


Val Arg Glu Pro Val Ser Pro Leu Phe Gly Ala Met Pro Lys Thr Asn 
    370                 375                 380                 


Gln Met Leu Glu Phe Gln Ile Thr Gln Glu Tyr Thr Gly Gln Gln Lys 
385                 390                 395                 400 


His Leu Cys Tyr Leu Val Pro Gln Trp Lys Glu Ile Leu Asp Phe Asp 
                405                 410                 415     


Thr Phe Ala Asn Gly Lys Glu Ser Pro Val Lys Ser Ile Val Asp Gly 
            420                 425                 430         


Ser Gln Tyr Asp Tyr Lys Val Ser Gly Ile Thr Ala Val Ser Asn Val 
        435                 440                 445             


Gly Asn Asp Glu Asn Trp Thr Gly His Leu Leu Ala Gln Ala Asn Leu 
    450                 455                 460                 


Tyr Gly Tyr Gly Arg Leu Thr Trp Asn Pro Asn Leu Ser Thr Glu Glu 
465                 470                 475                 480 


Val Thr Thr Glu Trp Thr Arg Ala Thr Phe Gly Asp Asn Glu Glu Val 
                485                 490                 495     


Ile Gln Thr Ile His Glu Met Leu Leu Gln Ser Trp Leu Ile Tyr Glu 
            500                 505                 510         


Ser Tyr Thr Ala Pro Leu Gly Val Gly Trp Met Val Glu Pro Gly His 
        515                 520                 525             


His Tyr Gly Pro Asn Val Asp Gly Tyr Glu Tyr Ser Val Trp Gly Thr 
    530                 535                 540                 


Tyr His Tyr Ala Asp Cys His Gly Ile Gly Val Asp Arg Thr Val Ala 
545                 550                 555                 560 


Thr Gly Thr Gly Tyr Thr Ala Gln Tyr Phe Ala Glu Asn Tyr Glu Leu 
                565                 570                 575     


Tyr Glu His Leu Glu Thr Cys Pro Asp Ser Leu Leu Leu Phe Phe His 
            580                 585                 590         


His Val Pro Tyr Thr His Lys Leu Lys Ser Gly Val Thr Val Ile Gln 
        595                 600                 605             


His Ile Tyr Asp Thr His Phe Ser Gly Ala Glu Gln Ala Glu Gln Leu 
    610                 615                 620                 


Leu Glu Ser Trp Arg Ser Leu Glu Gly Lys Val Asp Ser Glu Arg Phe 
625                 630                 635                 640 


Gln Gln Val Leu Glu Arg Leu Glu His Gln Ala Glu His Ala Lys Glu 
                645                 650                 655     


Trp Arg Asp Val Ile Asn Thr Tyr Phe Tyr Arg Lys Ser Gly Ile Pro 
            660                 665                 670         


Asp Glu Lys Lys Arg Thr Ile Tyr Pro Ile 
        675                 680         


<210>  339
<211>  697
<212>  PRT
<213>  Clostridium cellulolyticum

<400>  339

Met Tyr Lys Ser Asn Val Asn Asp Glu Leu Tyr Gly Ala Asn Gly Tyr 
1               5                   10                  15      


Asn Cys Trp Leu Gly Tyr His Leu Leu Glu Asn Gly Glu Leu Arg Glu 
            20                  25                  30          


Asn Tyr Ser Gln Trp Ala Ser Asn Ile Val Ile Ser Lys Glu Pro Asp 
        35                  40                  45              


Glu Ile Lys Ile Ala Leu Ser Glu Leu Lys Ser Gly Ile Asn Gly Ile 
    50                  55                  60                  


Leu Gly Val Asp Ala Val Val Val Thr Arg Glu Pro Glu Gln Ser Ser 
65                  70                  75                  80  


Cys Ile Ala Leu Gly Val Leu Gly Arg Gly Gln Asn Ile Asp Ser Tyr 
                85                  90                  95      


Val Lys Tyr Asp Glu Val Val Gln Ile Gly Asn Glu Gly Phe Ile Ile 
            100                 105                 110         


Lys Ala Phe Lys Thr Gly Asn Ser Glu Ile Val Val Val Ala Gly Thr 
        115                 120                 125             


Thr Thr Lys Gly Leu Leu Tyr Gly Val Phe Ser Leu Leu Arg Leu Leu 
    130                 135                 140                 


Gln Thr Glu Ala Thr Ile Ser Gly Ile Leu Lys Ile Glu Asn Pro Ala 
145                 150                 155                 160 


Asn Gln Leu Arg Ile Ile Asn His Trp Asp Asn Ile Asp Gly Ser Ile 
                165                 170                 175     


Glu Arg Gly Tyr Ala Gly Lys Ser Ile Phe Phe Thr Asp Asn Lys Val 
            180                 185                 190         


Thr Glu Asp Leu Gly Arg Ile Lys Asp Tyr Ala Arg Leu Leu Cys Ser 
        195                 200                 205             


Val Gly Ile Asn Ser Ile Val Ile Asn Asn Val Asn Val His Lys Tyr 
    210                 215                 220                 


Glu Ser Met Leu Ile Thr Asp Lys Tyr Leu Asn Asp Val Ala Ser Leu 
225                 230                 235                 240 


Ala Gln Ile Phe Arg Asp Tyr Gly Ile Lys Leu Tyr Leu Ser Ala Asn 
                245                 250                 255     


Phe Ala Ser Thr Ile Glu Ile Gly Gly Leu Ala Thr Ala Asp Pro Leu 
            260                 265                 270         


Asp Pro Gln Val Arg Lys Trp Trp Lys Glu Lys Ala Asp Glu Ile Tyr 
        275                 280                 285             


Ser Leu Ile Pro Asp Phe Gly Gly Phe Leu Ile Lys Ala Asp Ser Glu 
    290                 295                 300                 


Phe Arg Pro Gly Pro Phe Thr Tyr Gly Arg Thr His Ala Asp Gly Ala 
305                 310                 315                 320 


Asn Met Leu Ala Glu Ala Leu Glu Pro Tyr Gly Gly Leu Val Ile Trp 
                325                 330                 335     


Arg Cys Phe Val Tyr Asn Cys Met Gln Asp Trp Arg Asp Arg Ile Thr 
            340                 345                 350         


Asp Arg Ala Arg Ala Ala Tyr Asp Asn Phe Met Pro Leu Asp Gly Leu 
        355                 360                 365             


Phe Arg Glu Asn Val Leu Leu Gln Ile Lys Asn Gly Pro Met Asp Phe 
    370                 375                 380                 


Gln Val Arg Glu Pro Val Ser Pro Leu Phe Gly Gly Leu Gln Lys Thr 
385                 390                 395                 400 


Asn Gln Leu Leu Glu Leu Gln Ile Thr Gln Glu Tyr Thr Gly Gln Gln 
                405                 410                 415     


Lys His Leu Cys Tyr Leu Val Pro Met Trp Lys Glu Ile Leu Asp Phe 
            420                 425                 430         


Asp Thr Met Ala Lys Gly Arg Asn Thr Ser Val Lys Lys Ile Ile Thr 
        435                 440                 445             


Gly Ser Val Phe Asn Asn Lys Leu Gly Gly Met Ala Ala Val Thr Asn 
    450                 455                 460                 


Ile Gly Asn Asp Leu Asn Trp Thr Gly His Gln Met Ala Gln Ser Asn 
465                 470                 475                 480 


Thr Tyr Gly Tyr Ala Arg Leu Cys Trp Asn Pro Asp Leu Ser Ala Glu 
                485                 490                 495     


Lys Ile Thr Asp Glu Trp Val Arg Met Thr Tyr Ser Asn Tyr Glu Lys 
            500                 505                 510         


Val Val Asn Thr Val Lys Glu Met Leu Leu Gly Ser Trp Arg Thr Tyr 
        515                 520                 525             


Glu Asn Tyr Thr Ser Pro Leu Gly Ile Gly Trp Met Val Asn Pro Asn 
    530                 535                 540                 


His His Tyr Gly Pro Asn Val Asp Gly Tyr Glu Tyr Asp Lys Trp Gly 
545                 550                 555                 560 


Thr Tyr His Arg Ala Asp His Lys Gly Ile Gly Val Asp Arg Thr Val 
                565                 570                 575     


Lys Ser Gly Thr Gly Tyr Ala Gly Gln Tyr His Lys Asp Val Ala Gly 
            580                 585                 590         


Ile Tyr Glu Asp Met Asp Lys Cys Pro Glu Glu Leu Leu Leu Phe Phe 
        595                 600                 605             


His His Met Pro Tyr Asp Tyr Ile Leu Lys Ser Gly Glu Thr Leu Ile 
    610                 615                 620                 


Gln Tyr Ile Tyr Asn Thr His Phe Lys Gly Val Glu Glu Val Glu Glu 
625                 630                 635                 640 


Leu Arg Asn Lys Trp Phe Ser Leu Lys Gly Trp Ile Ser Glu Glu Ile 
                645                 650                 655     


Phe Leu His Val Leu Glu Arg Leu Asp Gly Gln Leu Glu His Ser Lys 
            660                 665                 670         


Glu Trp Arg Asp Val Ile Asn Thr Tyr Phe Tyr Arg Lys Thr Gly Ile 
        675                 680                 685             


Ser Asp Glu Leu Gly Arg Lys Ile Tyr 
    690                 695         


<210>  340
<211>  674
<212>  PRT
<213>  Thermotoga petrophila

<400>  340

Met Asp Tyr Arg Met Cys Trp Leu Glu Tyr Arg Gly Leu Pro Ala Asp 
1               5                   10                  15      


Val Ala Lys Lys Leu Lys Asp Trp Phe Ser Ser Val Ser Ile Leu Glu 
            20                  25                  30          


Pro Gly Ser Ser Val Leu Lys Asp Glu Ile Arg Arg Phe Ser Glu Arg 
        35                  40                  45              


Ser Ile Gly Ile Thr Pro Gly Phe Tyr Ser Arg Pro Leu Lys Lys Glu 
    50                  55                  60                  


Lys Tyr Ile Met Val Gly Arg Leu Glu Ser Leu Pro Ile Lys Phe Asp 
65                  70                  75                  80  


Glu Asn Leu Gly Glu Glu Gly Phe Met Leu Arg Thr Leu Glu Trp Asn 
                85                  90                  95      


Gly Ser Lys Ile Leu Leu Val Thr Gly Glu Thr Lys Lys Ala Leu Val 
            100                 105                 110         


Tyr Gly Ile Phe Asp Leu Met Lys Ile Ile Arg Leu Gly Glu Asp Ile 
        115                 120                 125             


Glu Lys Met Asn Val Leu Glu Lys Pro Lys Ala Lys Phe Arg Met Leu 
    130                 135                 140                 


Asn His Cys Asp Asn Leu Asp Gly Thr Ile Glu Arg Gly Tyr Ala Gly 
145                 150                 155                 160 


Asn Ser Ile Phe Phe Lys Asp Asn Arg Ile Ile Ile Asn Gln Arg Thr 
                165                 170                 175     


Lys Asp Tyr Ala Arg Leu Leu Ala Ser Ile Gly Ile Asn Gly Val Val 
            180                 185                 190         


Ile Asn Asn Val Asn Val Lys Lys Arg Glu Val Tyr Leu Ile Asp Ser 
        195                 200                 205             


Ile Tyr Leu Lys Arg Leu Lys Lys Leu Ala Asp Ile Phe Arg Glu Tyr 
    210                 215                 220                 


Gly Ile Lys Ile Tyr Leu Ser Ile Asn Phe Ala Ser Pro Val Tyr Leu 
225                 230                 235                 240 


Arg Gly Leu Asp Thr Ala Asp Pro Leu Asp Glu Arg Val Ala His Trp 
                245                 250                 255     


Trp Arg Glu Lys Ala Arg Glu Ile Tyr Asp His Ile Pro Asp Phe Gly 
            260                 265                 270         


Gly Phe Leu Val Lys Ala Asp Ser Glu Phe Asn Pro Gly Pro His Met 
        275                 280                 285             


Phe Gly Arg Thr His Ala Glu Gly Ala Asn Met Leu Ala Arg Ala Leu 
    290                 295                 300                 


Ala Pro Phe Gly Gly Val Val Ile Trp Arg Ala Phe Val Tyr Asn Cys 
305                 310                 315                 320 


Leu Gln Asp Trp Arg Asp Tyr Lys Thr Asp Arg Ala Lys Ala Ala Tyr 
                325                 330                 335     


Asp Asn Phe Lys Pro Leu Asp Gly Gln Phe Asp Asp Asn Val Ile Ile 
            340                 345                 350         


Gln Ile Lys Tyr Gly Pro Met Asp Phe Gln Val Arg Glu Pro Val Asn 
        355                 360                 365             


Pro Leu Phe Gly Gly Met Glu Arg Thr Asn Gln Ile Leu Glu Leu Gln 
    370                 375                 380                 


Ile Thr Gln Glu Tyr Thr Gly Gln Gln Ile His Leu Cys Phe Leu Gly 
385                 390                 395                 400 


Asn Leu Trp Lys Glu Ile Leu Glu Phe Asp Thr Phe Ala Lys Gly Glu 
                405                 410                 415     


Gly Ser Tyr Val Lys Arg Ile Val Asp Gly Thr Leu Phe Asp Arg Lys 
            420                 425                 430         


Asn Asn Gly Phe Ala Gly Val Ser Asn Val Gly Asp Ser Val Asn Trp 
        435                 440                 445             


Thr Gly His Asp Leu Ala Gln Ala Asn Leu Tyr Ala Phe Gly Arg Leu 
    450                 455                 460                 


Ala Trp Asn Pro Asp Glu Glu Ile Glu Arg Ile Val Glu Glu Trp Ile 
465                 470                 475                 480 


Lys Leu Thr Phe Gly Asp Asp Glu Lys Val Leu Glu Asn Val Ser Tyr 
                485                 490                 495     


Met Leu Met Lys Ser His Arg Thr Tyr Glu Lys Tyr Thr Thr Pro Phe 
            500                 505                 510         


Gly Leu Gly Trp Met Val Asn Pro Gly His His Tyr Gly Pro Asn Pro 
        515                 520                 525             


Glu Gly Tyr Glu Tyr Ser Lys Trp Gly Thr Tyr His Arg Ala Asn Trp 
    530                 535                 540                 


Glu Ala Ile Gly Val Asp Arg Thr Ser Arg Gly Thr Gly Tyr Thr Leu 
545                 550                 555                 560 


Gln Tyr His Ser Pro Trp Lys Glu Ile Tyr Asp Asp Ile Asn Thr Cys 
                565                 570                 575     


Pro Glu Asp Leu Leu Leu Phe Phe His Arg Val Arg Tyr Asp His Arg 
            580                 585                 590         


Leu Lys Ser Gly Lys Thr Leu Leu Gln Thr Ile Tyr Asp Leu His Phe 
        595                 600                 605             


Glu Gly Val Glu Glu Val Glu Glu Phe Ile Lys Lys Trp Glu Glu Leu 
    610                 615                 620                 


Lys Asp Arg Val Pro Pro Asp Ile Phe Glu Arg Val Lys Glu Arg Leu 
625                 630                 635                 640 


His Met Gln Leu Glu His Ala Lys Glu Trp Arg Asp Val Ile Asn Thr 
                645                 650                 655     


Tyr Phe Tyr Arg Arg Thr Gly Ile Pro Asp Glu Lys Gly Arg Lys Ile 
            660                 665                 670         


Tyr Pro 
        


<210>  341
<211>  674
<212>  PRT
<213>  Thermotoga maritima

<400>  341

Met Asp Tyr Arg Met Cys Trp Leu Glu Tyr Arg Gly Leu Pro Ala Asp 
1               5                   10                  15      


Val Ala Gly Lys Leu Lys Asp Trp Phe Ser Ser Val Ser Ile Leu Glu 
            20                  25                  30          


Pro Gly Ser Ser Val Leu Lys Asp Glu Ile Arg Arg Phe Ser Glu Arg 
        35                  40                  45              


Ser Ile Gly Ile Thr Pro Arg Phe Tyr Ser Arg Pro Leu Lys Lys Glu 
    50                  55                  60                  


Lys Tyr Ile Met Val Gly Arg Leu Glu Ser Leu Pro Ile Lys Leu Asp 
65                  70                  75                  80  


Val Asn Leu Gly Glu Glu Gly Phe Met Leu Arg Thr Ile Glu Trp Asn 
                85                  90                  95      


Gly Ser Lys Ile Leu Leu Val Thr Gly Glu Thr Lys Lys Ala Leu Val 
            100                 105                 110         


Tyr Gly Ile Phe Asp Leu Met Lys Arg Ile Arg Leu Gly Glu Asp Ile 
        115                 120                 125             


Glu Lys Met Asn Val Leu Ala Lys Pro Lys Ala Lys Phe Arg Met Leu 
    130                 135                 140                 


Asn His Trp Asp Asn Leu Asp Gly Thr Ile Glu Arg Gly Tyr Ala Gly 
145                 150                 155                 160 


Asn Ser Ile Phe Phe Lys Asp Asn Arg Ile Ile Ile Asn Gln Arg Thr 
                165                 170                 175     


Lys Asp Tyr Ala Arg Leu Leu Ala Ser Ile Gly Ile Asn Gly Val Val 
            180                 185                 190         


Ile Asn Asn Val Asn Val Lys Lys Arg Glu Val Tyr Leu Ile Asp Ser 
        195                 200                 205             


Ile Tyr Leu Lys Lys Leu Lys Lys Leu Ala Asp Ile Phe Arg Glu Tyr 
    210                 215                 220                 


Gly Ile Lys Ile Tyr Leu Ser Ile Asn Phe Ala Ser Pro Val Tyr Leu 
225                 230                 235                 240 


Gly Gly Leu Asp Thr Ala Asp Pro Leu Asp Glu Arg Val Ala Arg Trp 
                245                 250                 255     


Trp Arg Glu Lys Ala Arg Gly Ile Tyr Asp Tyr Ile Pro Asp Phe Gly 
            260                 265                 270         


Gly Phe Leu Val Lys Ala Asp Ser Glu Phe Asn Pro Gly Pro His Met 
        275                 280                 285             


Phe Gly Arg Thr His Ala Glu Gly Ala Asn Met Leu Ala Arg Ala Leu 
    290                 295                 300                 


Ala Pro Phe Gly Gly Val Val Ile Trp Arg Ala Phe Val Tyr Asn Cys 
305                 310                 315                 320 


Leu Gln Asp Trp Arg Asp Tyr Lys Thr Asp Arg Ala Lys Ala Ala Tyr 
                325                 330                 335     


Asp Asn Phe Lys Pro Leu Asp Gly Gln Phe Asp Asp Asn Val Ile Ile 
            340                 345                 350         


Gln Ile Lys Tyr Gly Pro Met Asp Phe Gln Val Arg Glu Pro Val Asn 
        355                 360                 365             


Pro Leu Phe Gly Gly Met Glu Lys Thr Asn Gln Ile Leu Glu Leu Gln 
    370                 375                 380                 


Ile Thr Gln Glu Tyr Thr Gly Gln Gln Ile His Leu Cys Phe Leu Gly 
385                 390                 395                 400 


Thr Leu Trp Lys Glu Ile Leu Glu Phe Asp Thr Phe Ala Lys Gly Glu 
                405                 410                 415     


Gly Ser Tyr Val Lys Arg Ile Val Asp Gly Thr Leu Phe Asp Arg Glu 
            420                 425                 430         


Asn Asn Gly Phe Ala Gly Val Ser Asn Val Gly Asp Ser Val Asn Trp 
        435                 440                 445             


Thr Gly His Asp Leu Ala Gln Ala Asn Leu Tyr Ala Phe Gly Arg Leu 
    450                 455                 460                 


Ala Trp Asn Pro Asp Glu Glu Ile Glu Arg Ile Val Glu Glu Trp Ile 
465                 470                 475                 480 


Lys Leu Thr Phe Gly Asp Asp Glu Lys Val Leu Glu Asn Val Ser Tyr 
                485                 490                 495     


Met Leu Met Lys Ser His Arg Thr Tyr Glu Lys Tyr Thr Thr Pro Phe 
            500                 505                 510         


Gly Leu Gly Trp Met Val Asn Pro Gly His His Tyr Gly Pro Asn Pro 
        515                 520                 525             


Glu Gly Tyr Glu Tyr Ser Lys Trp Gly Thr Tyr His Arg Ala Asn Trp 
    530                 535                 540                 


Glu Ala Ile Gly Val Asp Arg Thr Ser Arg Gly Thr Gly Tyr Thr Leu 
545                 550                 555                 560 


Gln Tyr His Ser Pro Trp Lys Glu Ile Tyr Asp Asp Ile Asn Thr Cys 
                565                 570                 575     


Pro Glu Asp Leu Leu Leu Phe Phe His Arg Val Arg Tyr Asp His Arg 
            580                 585                 590         


Leu Lys Ser Gly Lys Thr Leu Leu Gln Thr Met Tyr Asp Leu His Phe 
        595                 600                 605             


Glu Gly Val Glu Glu Val Glu Glu Phe Ile Lys Lys Trp Glu Glu Leu 
    610                 615                 620                 


Lys Asp Arg Val Ser Pro Asp Ile Phe Glu Arg Val Lys Glu Arg Leu 
625                 630                 635                 640 


His Met Gln Leu Glu His Ala Lys Glu Trp Arg Asp Val Ile Asn Thr 
                645                 650                 655     


Tyr Phe Tyr Arg Arg Thr Gly Ile Pro Asp Glu Lys Gly Arg Lys Ile 
            660                 665                 670         


Tyr Pro 
        


<210>  342
<211>  834
<212>  PRT
<213>  Solibacter usitatus

<400>  342

Met Ser Phe Lys Phe Leu Ala Leu Leu Leu Thr Ile Pro Ala Val His 
1               5                   10                  15      


Ala Glu Thr Gly Tyr Asp Ala Trp Leu Arg Tyr Ala Pro Leu Ser Asp 
            20                  25                  30          


Ala Ala Ala Arg Pro Tyr Leu Thr Ala Leu Pro Ala Ala Val Thr Val 
        35                  40                  45              


Tyr Gly Ala Ser Pro Val Val Gln Ser Ala Gln Arg Glu Leu Leu Arg 
    50                  55                  60                  


Gly Val Arg Gly Met Leu Gly Arg Thr Leu Arg Met Glu Ser Lys Leu 
65                  70                  75                  80  


Pro Ala Glu Arg Ala Ile Leu Leu Gly Thr Ala Gly Asp Leu Gln Ala 
                85                  90                  95      


Ala Ile Pro Gln Leu His Leu Pro Pro Asp Leu Pro Ala Asp Ser Tyr 
            100                 105                 110         


Leu Val Thr Thr Val Thr Ala Asn Gly Ala Pro His Leu Val Ile Ala 
        115                 120                 125             


Gly Ala Asn Asp Arg Ala Val Leu Tyr Gly Val Phe Ala Leu Leu Arg 
    130                 135                 140                 


Lys Ile Gly Thr Gly Gln Thr Leu Asn Asp Asp Asp Pro Val Gln Thr 
145                 150                 155                 160 


Pro Tyr Ala Pro Val Arg Trp Val Asn Glu Trp Asn Asn Leu Asp Gly 
                165                 170                 175     


Thr Ile Glu Arg Gly Tyr Gly Gly Arg Ser Ile Phe Trp Asp Asn Asn 
            180                 185                 190         


Arg Ala Arg Ala Asp Leu Thr Arg Val Ala Asp Tyr Gly Arg Met Leu 
        195                 200                 205             


Ala Ser Leu Gly Ile Gln Ala Cys Ser Ile Asn Asn Val Asn Ala Asn 
    210                 215                 220                 


Pro Arg Val Leu Ala Ser Asp Phe Leu Pro Glu Ile Val Arg Ile Ala 
225                 230                 235                 240 


Glu Ala Phe Arg Pro Trp Gly Ile Arg Val Ala Leu Ala Val Asp Phe 
                245                 250                 255     


Gly Ser Pro Lys Thr Ile Gly Gly Leu Asp Thr Phe Asp Pro Val Asp 
            260                 265                 270         


Pro Lys Val Ala Ala Trp Trp Lys Ser Lys Ile Asp Glu Leu Tyr Arg 
        275                 280                 285             


Ala Val Pro Asp Leu Ala Gly Ile Val Leu Lys Ala Asp Ser Glu Gly 
    290                 295                 300                 


Arg Val Gly Pro Ser Thr Tyr Gly Arg Thr His Ala Asp Ala Ala Asn 
305                 310                 315                 320 


Val Val Ala Arg Gly Leu Gln Pro His Gly Gly Leu Leu Phe Tyr Arg 
                325                 330                 335     


Gly Phe Val Tyr Asp His His Met Asp Trp Lys Asn Pro Lys Asn Asp 
            340                 345                 350         


Arg Gly Arg Ala Ala Tyr Asp Asn Phe Gln Pro Leu Asp Gly Lys Phe 
        355                 360                 365             


Asp Ala Asn Val Ile Val Gln Ile Lys His Gly Pro Ile Asp Phe Gln 
    370                 375                 380                 


Val Arg Glu Pro Ala Ser Pro Leu Phe Ala Ala Leu Glu Lys Thr Asn 
385                 390                 395                 400 


Gln Ala Ile Glu Leu Gln Ile Thr Gln Glu Tyr Phe Gly Gln Ser Arg 
                405                 410                 415     


His Asn Val Phe Leu Val Pro Met Trp Lys Thr Ala Leu Asp Phe Asp 
            420                 425                 430         


Met Gln Ala Gly Gly Thr Thr Pro Val Lys Ala Leu Ala Ala Gly Lys 
        435                 440                 445             


Val Phe His Arg Pro Ile Gly Gly Phe Val Gly Val Ser Asn Ile Gly 
    450                 455                 460                 


Leu Asp Asp Asn Trp Ser Gly Asn Gln Leu Ser Gln Ala Asn Leu Tyr 
465                 470                 475                 480 


Gly Phe Gly Arg Leu Ala Trp Asn Pro Asp Leu Thr Ser Gln Gln Ile 
                485                 490                 495     


Ile Asp Glu Trp Thr Arg Leu Thr Phe Gly Asn Glu Pro Lys Thr Val 
            500                 505                 510         


Glu Thr Ile Thr Ala Met Gln Leu Ala Ser Trp Pro Val Phe Glu Lys 
        515                 520                 525             


Tyr Thr Gly Pro Leu Gly Leu Gln Thr Leu Thr Asp Ile Val Gly Asp 
    530                 535                 540                 


His Tyr Gly Val Ala Val Glu Ala Ser Glu His Asn Gly Trp Gly Gln 
545                 550                 555                 560 


Trp His Asn Ala Asp Glu Lys Gly Val Gly Met Asp Arg Thr Val Ala 
                565                 570                 575     


Thr Gly Thr Gly Tyr Ile Gly Gln Tyr Arg Pro Pro Val Ala Lys Met 
            580                 585                 590         


Tyr Glu Ser Leu Glu Thr Cys Pro Asp Asp Leu Leu Leu Phe Leu His 
        595                 600                 605             


His Val Pro Tyr Thr Tyr Lys Leu His Ser Gly Lys Thr Val Ile Gln 
    610                 615                 620                 


Tyr Leu Tyr Asp Ser His Tyr Glu Gly Ala Asp Ala Val Ala Ala Trp 
625                 630                 635                 640 


Val Arg Asp Phe Gln Ser Leu Arg Gly His Ile Asp Asp Gln Arg Tyr 
                645                 650                 655     


Asn Glu Val Leu Ala Gln Leu Arg Tyr Gln Ala Ala His Val Glu Val 
            660                 665                 670         


Trp Arg Asp Ala Val Asn Asn Trp Phe His Arg Glu Ser Gly Ile Ala 
        675                 680                 685             


Asp Ala Lys Gly Arg Val Gly Asn His Pro Gly Arg Ser Glu Ala Glu 
    690                 695                 700                 


Ala Met Lys Leu Glu Gly Tyr Thr Val Ala Glu Ile Thr Pro Trp Glu 
705                 710                 715                 720 


Ser Ala Ser Gly Gly Lys Ala Val Thr Cys Pro Ala Ser Lys Cys Thr 
                725                 730                 735     


Ala Ser Met Gln Phe Ser Gly Ala Pro Gly Trp Tyr Thr Leu Arg Val 
            740                 745                 750         


Gln Tyr Phe Asp Leu Asn Gly Pro Val Ser Ser Phe Lys Leu Trp Val 
        755                 760                 765             


Gly Asn Gln Leu Val Asp Glu Trp Ser Ala Thr Asp His Leu Pro Ala 
    770                 775                 780                 


Arg Lys Leu Asp Ala Ser Ser Ser Thr Arg Arg Glu Val Ser Gly Ile 
785                 790                 795                 800 


Ala Leu Arg Pro Gly Asp Gln Val Arg Ile Glu Ala Ile Pro Glu Gly 
                805                 810                 815     


Arg Glu Leu Ala Ala Leu Asp Tyr Leu Glu Ile Leu Pro Asn Glu Pro 
            820                 825                 830         


Arg Gln 
        


<210>  343
<211>  2073
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 336

<400>  343
ttgacgcaaa tccctgaggg cgatctcgac taccgcgctt ggttgcagga gagcccgctg     60

ccccgcgccg tgccggaagc ggcgcggcgg atggcggtgt acggcccggc ggatgatccg    120

ctcctttgca ccgcggcggc ggagtggggg cgcgcggtcc gcgcggcgtg cggggaaagc    180

ccggcgcgct tggcgagaga cccgggcggt gcgccgagtg tgccttgcgt cgccatgggg    240

ctattgtcgg cgatgccacg cgggcttcgc gaggccgcgc aggctgcgct cgccggcgcg    300

ccttcggacg aggcctacgc catcttgccg gtggatgggc aaggcgtcgc agtcgtctcg    360

cggacgcccg ccggtgtgct gtacggcgtg ttccacctca tccgccgcct gcggctcggc    420

gaaccgctcc acgagccttg cgtctcctca cccaagaacg cctggcggat gctggatcac    480

tgggacaacg ccgacggcac gattgagcgc gggtacgcgg ggaaatcgct gttttaccgc    540

ggtggtcaaa tcgattttga cgaggggcgc gtacgggatt acgcgcggct tttggcgtct    600

gtcggcgtga acgccatcgc catcaacaac gtcaacgtgc acgagaccga gacgcgcttc    660

ctcaccgagg cgcatctgcc gggcgtcgcg cggctggccg acgtgtttcg cccgtacggc    720

atccgggtgt tcctcagcat caacttcgcg agccccgtcg atctcggcga cctgccgacc    780

gcggatccgc tcgatccgcg cgttgaggac tggtggcgcg cgacggcgga tcgcatctac    840

cggcacatcc cggacttcgg cggcttcctc gtgaaagcgg actccgagtt ccggcccggt    900

cccttcacct acgggcgcga tcatgccgac ggcgcgaaca tgctcgcccg agcgctggcg    960

cctcacggcg gcgtggtcat ctggcgggcc ttcgtgtaca actgcctcat ggactggcgg   1020

gaccggcgcg ccgaccgcgc ccgggcggcg tacgatcact tcgtgccgct cgacggccgc   1080

ttcctggaca acgtcctgat tcagatcaag aacgggccga tggactttca ggtgcgcgag   1140

ccggtctcgc cgctcttcgg cgggctttct gcgacgaacg tgatgctcga gttccagatc   1200

acgcaggagt acaccggcca gcagcgccac gtgtgctatc tcgcgccgat gtggaaagag   1260

gtgctcgact tcgacacgca cgcgcgcggg ccgggatcga cggtggccga gatcgcgagc   1320

ggcaggttgt tcgggcggcc gcacggcggc gtggcgggcg tcgcgaacgt gggcgacgat   1380

gtcaactgga cggggcactc gctggcgcag gcgaacctgt acgcgttcgg ccgactcgct   1440

tgggatccgt cgctcgatcc cgccgggatc gcgcgggagt gggcgcggct cacgtacggc   1500

gacgatccgg atgtcgtccg cacggtggtg ggcatcctca tggcctcctg gccggcgtac   1560

gaggcgtaca ccgcgccgct cggcgtgggc tggatggtga accccggcca ccacgacggg   1620

cccaatccgg agggctacga gtactcaaaa tggggcacgt accactacgc ggattggcga   1680

ggtgtcggcg tggatcggac gatggccacg ggcacgggct acaccggcca gtaccacgag   1740

ccgatgcgaa gcctgtacga gcacctggag acgtgccccg acgagcttct cctcttcttc   1800

catcatgtgc cgtacacgca cgtgctccac tccgggaaga cggtcattca gcacatctac   1860

gacgcgcact tcgacggcgt cgaggcggtg gcctggatga tcgaggcgtg gcggcggctt   1920

caggggcgga tcgatcccgt ccgcttcgag cgcgtcctcg cgcggctcga ggatcagatg   1980

cagcgcgccg tcgagtggcg ggacgtgatc aacacgtact tttatcgaaa gtgtggcatt   2040

cccgacgcac gggggctcca catctacccg tga                                2073


<210>  344
<211>  2073
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 336

<400>  344
ttgacgaacg tccctgaggg cgatctcgac taccgcgctt ggttgcagga gagcccgctg     60

ccccgcgccg tgccggaagc ggcgcggcgg atggcggtgt acggcccggc ggatgatccg    120

ctcctttgca ccgcggcggc ggagtggggg cgcgcggtcc gcgcggcgtg cggggaaagc    180

ccggcgcgct tggcgagaga cccgggcggt gcgccgagtg tgccttgcgt cgccatgggg    240

ctattgtcgg cgatgccacg cgggcttcgc gaggccgcgc aggctgcgct cgccggcgcg    300

ccttcggacg aggcctacgc catcttgccg gtggatgggc aaggcgtcgc agtcgtctcg    360

cggacgcccg ccggtgtgct gtacggcgtg ttccacctca tccgccgcct gcggctcggc    420

gaaccgctcc acgagccttg cgtctcctca cccaagaacg cctggcggat gctggatcac    480

tgggacaacg ccgacggcac gattgagcgc gggtacgcgg ggaaatcgct gttttaccgc    540

ggtggtcaaa tcgattttga cgaggggcgc gtacgggatt acgcgcggct tttggcgtct    600

gtcggcgtga acgccatcgc catcaacaac gtcaacgtgc acgagaccga gacgcgcttc    660

ctcaccgagg cgcatctgcc gggcgtcgcg cggctggccg acgtgtttcg cccgtacggc    720

atccgggtgt tcctcagcat caacttcgcg agccccgtcg atctcggcga cctgccgacc    780

gcggatccgc tcgatccgcg cgttgaggac tggtggcgcg cgacggcgga tcgcatctac    840

cggcacatcc cggacttcgg cggcttcctc gtgaaagcgg actccgagtt ccggcccggt    900

cccttcacct acgggcgcga tcatgccgac ggcgcgaaca tgctcgcccg agcgctggcg    960

cctcacggcg gcgtggtcat ctggcgggcc ttcgtgtaca actgcctcat ggactggcgg   1020

gaccggcgcg ccgaccgcgc ccgggcggcg tacgatcact tcgtgccgct cgacggccgc   1080

ttcctggaca acgtcctgat tcagatcaag aacgggccga tggactttca ggtgcgcgag   1140

ccggtctcgc cgctcttcgg cgggctttct gcgacgaacg tgatgctcga gttccagatc   1200

acgcaggagt acaccggcca gcagcgccac gtgtgctatc tcgcgccgat gtggaaagag   1260

gtgctcgact tcgacacgca cgcgcgcggg ccgggatcga cggtggccga gatcgcgagc   1320

ggcaggttgt tcgggcggcc gcacggcggc gtggcgggcg tcgcgaacgt gggcgacgat   1380

gtcaactgga cggggcactc gctggcgcag gcgaacctgt acgcgttcgg ccgactcgct   1440

tgggatccgt cgctcgatcc cgccgggatc gcgcgggagt gggcgcggct cacgtacggc   1500

gacgatccgg atgtcgtccg cacggtggtg ggcatcctca tggcctcctg gccggcgtac   1560

gaggcgtaca ccgcgccgct cggcgtgggc tggatggtga accccggcca ccacgacggg   1620

cccaatccgg agggctacga gtactcaaaa tggggcacgt accactacgc ggattggcga   1680

ggtgtcggcg tggatcggac gatggccacg ggcacgggct acaccggcca gtaccacgag   1740

ccgatgcgaa gcctgtacga gcacctggag acgtgccccg acgagcttct cctcttcttc   1800

catcatgtgc cgtacacgca cgtgctccac tccgggaaga cggtcattca gcacatctac   1860

gacgcgcact tcgacggcgt cgaggcggtg gcctggatga tcgaggcgtg gcggcggctt   1920

caggggcgga tcgatcccgt ccgcttcgag cgcgtcctcg cgcggctcga ggatcagatg   1980

cagcgcgccg tcgagtggcg ggacgtgatc aacacgtact tttatcgaaa gtgtggcatt   2040

cccgacgcac gggggctcca catctacccg tga                                2073


<210>  345
<211>  2073
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 336

<400>  345
ttgacgaacc tccctgaggg cgatctcgac taccgcgctt ggttgcagga gagcccgctg     60

ccccgcgccg tgccggaagc ggcgcggcgg atggcggtgt acggcccggc ggatgatccg    120

ctcctttgca ccgcggcggc ggagtggggg cgcgcggtcc gcgcggcgtg cggggaaagc    180

ccggcgcgct tggcgagaga cccgggcggt gcgccgagtg tgccttgcgt cgccatgggg    240

ctattgtcgg cgatgccacg cgggcttcgc gaggccgcgc aggctgcgct cgccggcgcg    300

ccttcggacg aggcctacgc catcttgccg gtggatgggc aaggcgtcgc agtcgtctcg    360

cggacgcccg ccggtgtgct gtacggcgtg ttccacctca tccgccgcct gcggctcggc    420

gaaccgctcc acgagccttg cgtctcctca cccaagaacg cctggcggat gctggatcac    480

tgggacaacg ccgacggcac gattgagcgc gggtacgcgg ggaaatcgct gttttaccgc    540

ggtggtcaaa tcgattttga cgaggggcgc gtacgggatt acgcgcggct tttggcgtct    600

gtcggcgtga acgccatcgc catcaacaac gtcaacgtgc acgagaccga gacgcgcttc    660

ctcaccgagg cgcatctgcc gggcgtcgcg cggctggccg acgtgtttcg cccgtacggc    720

atccgggtgt tcctcagcat caacttcgcg agccccgtcg atctcggcga cctgccgacc    780

gcggatccgc tcgatccgcg cgttgaggac tggtggcgcg cgacggcgga tcgcatctac    840

cggcacatcc cggacttcgg cggcttcctc gtgaaagcgg actccgagtt ccggcccggt    900

cccttcacct acgggcgcga tcatgccgac ggcgcgaaca tgctcgcccg agcgctggcg    960

cctcacggcg gcgtggtcat ctggcgggcc ttcgtgtaca actgcctcat ggactggcgg   1020

gaccggcgcg ccgaccgcgc ccgggcggcg tacgatcact tcgtgccgct cgacggccgc   1080

ttcctggaca acgtcctgat tcagatcaag aacgggccga tggactttca ggtgcgcgag   1140

ccggtctcgc cgctcttcgg cgggctttct gcgacgaacg tgatgctcga gttccagatc   1200

acgcaggagt acaccggcca gcagcgccac gtgtgctatc tcgcgccgat gtggaaagag   1260

gtgctcgact tcgacacgca cgcgcgcggg ccgggatcga cggtggccga gatcgcgagc   1320

ggcaggttgt tcgggcggcc gcacggcggc gtggcgggcg tcgcgaacgt gggcgacgat   1380

gtcaactgga cggggcactc gctggcgcag gcgaacctgt acgcgttcgg ccgactcgct   1440

tgggatccgt cgctcgatcc cgccgggatc gcgcgggagt gggcgcggct cacgtacggc   1500

gacgatccgg atgtcgtccg cacggtggtg ggcatcctca tggcctcctg gccggcgtac   1560

gaggcgtaca ccgcgccgct cggcgtgggc tggatggtga accccggcca ccacgacggg   1620

cccaatccgg agggctacga gtactcaaaa tggggcacgt accactacgc ggattggcga   1680

ggtgtcggcg tggatcggac gatggccacg ggcacgggct acaccggcca gtaccacgag   1740

ccgatgcgaa gcctgtacga gcacctggag acgtgccccg acgagcttct cctcttcttc   1800

catcatgtgc cgtacacgca cgtgctccac tccgggaaga cggtcattca gcacatctac   1860

gacgcgcact tcgacggcgt cgaggcggtg gcctggatga tcgaggcgtg gcggcggctt   1920

caggggcgga tcgatcccgt ccgcttcgag cgcgtcctcg cgcggctcga ggatcagatg   1980

cagcgcgccg tcgagtggcg ggacgtgatc aacacgtact tttatcgaaa gtgtggcatt   2040

cccgacgcac gggggctcca catctacccg tga                                2073


<210>  346
<211>  2073
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 336

<400>  346
ttgacgaaca tccctgacgg cgatctcgac taccgcgctt ggttgcagga gagcccgctg     60

ccccgcgccg tgccggaagc ggcgcggcgg atggcggtgt acggcccggc ggatgatccg    120

ctcctttgca ccgcggcggc ggagtggggg cgcgcggtcc gcgcggcgtg cggggaaagc    180

ccggcgcgct tggcgagaga cccgggcggt gcgccgagtg tgccttgcgt cgccatgggg    240

ctattgtcgg cgatgccacg cgggcttcgc gaggccgcgc aggctgcgct cgccggcgcg    300

ccttcggacg aggcctacgc catcttgccg gtggatgggc aaggcgtcgc agtcgtctcg    360

cggacgcccg ccggtgtgct gtacggcgtg ttccacctca tccgccgcct gcggctcggc    420

gaaccgctcc acgagccttg cgtctcctca cccaagaacg cctggcggat gctggatcac    480

tgggacaacg ccgacggcac gattgagcgc gggtacgcgg ggaaatcgct gttttaccgc    540

ggtggtcaaa tcgattttga cgaggggcgc gtacgggatt acgcgcggct tttggcgtct    600

gtcggcgtga acgccatcgc catcaacaac gtcaacgtgc acgagaccga gacgcgcttc    660

ctcaccgagg cgcatctgcc gggcgtcgcg cggctggccg acgtgtttcg cccgtacggc    720

atccgggtgt tcctcagcat caacttcgcg agccccgtcg atctcggcga cctgccgacc    780

gcggatccgc tcgatccgcg cgttgaggac tggtggcgcg cgacggcgga tcgcatctac    840

cggcacatcc cggacttcgg cggcttcctc gtgaaagcgg actccgagtt ccggcccggt    900

cccttcacct acgggcgcga tcatgccgac ggcgcgaaca tgctcgcccg agcgctggcg    960

cctcacggcg gcgtggtcat ctggcgggcc ttcgtgtaca actgcctcat ggactggcgg   1020

gaccggcgcg ccgaccgcgc ccgggcggcg tacgatcact tcgtgccgct cgacggccgc   1080

ttcctggaca acgtcctgat tcagatcaag aacgggccga tggactttca ggtgcgcgag   1140

ccggtctcgc cgctcttcgg cgggctttct gcgacgaacg tgatgctcga gttccagatc   1200

acgcaggagt acaccggcca gcagcgccac gtgtgctatc tcgcgccgat gtggaaagag   1260

gtgctcgact tcgacacgca cgcgcgcggg ccgggatcga cggtggccga gatcgcgagc   1320

ggcaggttgt tcgggcggcc gcacggcggc gtggcgggcg tcgcgaacgt gggcgacgat   1380

gtcaactgga cggggcactc gctggcgcag gcgaacctgt acgcgttcgg ccgactcgct   1440

tgggatccgt cgctcgatcc cgccgggatc gcgcgggagt gggcgcggct cacgtacggc   1500

gacgatccgg atgtcgtccg cacggtggtg ggcatcctca tggcctcctg gccggcgtac   1560

gaggcgtaca ccgcgccgct cggcgtgggc tggatggtga accccggcca ccacgacggg   1620

cccaatccgg agggctacga gtactcaaaa tggggcacgt accactacgc ggattggcga   1680

ggtgtcggcg tggatcggac gatggccacg ggcacgggct acaccggcca gtaccacgag   1740

ccgatgcgaa gcctgtacga gcacctggag acgtgccccg acgagcttct cctcttcttc   1800

catcatgtgc cgtacacgca cgtgctccac tccgggaaga cggtcattca gcacatctac   1860

gacgcgcact tcgacggcgt cgaggcggtg gcctggatga tcgaggcgtg gcggcggctt   1920

caggggcgga tcgatcccgt ccgcttcgag cgcgtcctcg cgcggctcga ggatcagatg   1980

cagcgcgccg tcgagtggcg ggacgtgatc aacacgtact tttatcgaaa gtgtggcatt   2040

cccgacgcac gggggctcca catctacccg tga                                2073


<210>  347
<211>  2073
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 336

<400>  347
ttgacgaaca tccctgaggg cgagctcgac taccgcgctt ggttgcagga gagcccgctg     60

ccccgcgccg tgccggaagc ggcgcggcgg atggcggtgt acggcccggc ggatgatccg    120

ctcctttgca ccgcggcggc ggagtggggg cgcgcggtcc gcgcggcgtg cggggaaagc    180

ccggcgcgct tggcgagaga cccgggcggt gcgccgagtg tgccttgcgt cgccatgggg    240

ctattgtcgg cgatgccacg cgggcttcgc gaggccgcgc aggctgcgct cgccggcgcg    300

ccttcggacg aggcctacgc catcttgccg gtggatgggc aaggcgtcgc agtcgtctcg    360

cggacgcccg ccggtgtgct gtacggcgtg ttccacctca tccgccgcct gcggctcggc    420

gaaccgctcc acgagccttg cgtctcctca cccaagaacg cctggcggat gctggatcac    480

tgggacaacg ccgacggcac gattgagcgc gggtacgcgg ggaaatcgct gttttaccgc    540

ggtggtcaaa tcgattttga cgaggggcgc gtacgggatt acgcgcggct tttggcgtct    600

gtcggcgtga acgccatcgc catcaacaac gtcaacgtgc acgagaccga gacgcgcttc    660

ctcaccgagg cgcatctgcc gggcgtcgcg cggctggccg acgtgtttcg cccgtacggc    720

atccgggtgt tcctcagcat caacttcgcg agccccgtcg atctcggcga cctgccgacc    780

gcggatccgc tcgatccgcg cgttgaggac tggtggcgcg cgacggcgga tcgcatctac    840

cggcacatcc cggacttcgg cggcttcctc gtgaaagcgg actccgagtt ccggcccggt    900

cccttcacct acgggcgcga tcatgccgac ggcgcgaaca tgctcgcccg agcgctggcg    960

cctcacggcg gcgtggtcat ctggcgggcc ttcgtgtaca actgcctcat ggactggcgg   1020

gaccggcgcg ccgaccgcgc ccgggcggcg tacgatcact tcgtgccgct cgacggccgc   1080

ttcctggaca acgtcctgat tcagatcaag aacgggccga tggactttca ggtgcgcgag   1140

ccggtctcgc cgctcttcgg cgggctttct gcgacgaacg tgatgctcga gttccagatc   1200

acgcaggagt acaccggcca gcagcgccac gtgtgctatc tcgcgccgat gtggaaagag   1260

gtgctcgact tcgacacgca cgcgcgcggg ccgggatcga cggtggccga gatcgcgagc   1320

ggcaggttgt tcgggcggcc gcacggcggc gtggcgggcg tcgcgaacgt gggcgacgat   1380

gtcaactgga cggggcactc gctggcgcag gcgaacctgt acgcgttcgg ccgactcgct   1440

tgggatccgt cgctcgatcc cgccgggatc gcgcgggagt gggcgcggct cacgtacggc   1500

gacgatccgg atgtcgtccg cacggtggtg ggcatcctca tggcctcctg gccggcgtac   1560

gaggcgtaca ccgcgccgct cggcgtgggc tggatggtga accccggcca ccacgacggg   1620

cccaatccgg agggctacga gtactcaaaa tggggcacgt accactacgc ggattggcga   1680

ggtgtcggcg tggatcggac gatggccacg ggcacgggct acaccggcca gtaccacgag   1740

ccgatgcgaa gcctgtacga gcacctggag acgtgccccg acgagcttct cctcttcttc   1800

catcatgtgc cgtacacgca cgtgctccac tccgggaaga cggtcattca gcacatctac   1860

gacgcgcact tcgacggcgt cgaggcggtg gcctggatga tcgaggcgtg gcggcggctt   1920

caggggcgga tcgatcccgt ccgcttcgag cgcgtcctcg cgcggctcga ggatcagatg   1980

cagcgcgccg tcgagtggcg ggacgtgatc aacacgtact tttatcgaaa gtgtggcatt   2040

cccgacgcac gggggctcca catctacccg tga                                2073


<210>  348
<211>  690
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:337 and encoded by SEQ ID NO:343

<400>  348

Met Thr Gln Ile Pro Glu Gly Asp Leu Asp Tyr Arg Ala Trp Leu Gln 
1               5                   10                  15      


Glu Ser Pro Leu Pro Arg Ala Val Pro Glu Ala Ala Arg Arg Met Ala 
            20                  25                  30          


Val Tyr Gly Pro Ala Asp Asp Pro Leu Leu Cys Thr Ala Ala Ala Glu 
        35                  40                  45              


Trp Gly Arg Ala Val Arg Ala Ala Cys Gly Glu Ser Pro Ala Arg Leu 
    50                  55                  60                  


Ala Arg Asp Pro Gly Gly Ala Pro Ser Val Pro Cys Val Ala Met Gly 
65                  70                  75                  80  


Leu Leu Ser Ala Met Pro Arg Gly Leu Arg Glu Ala Ala Gln Ala Ala 
                85                  90                  95      


Leu Ala Gly Ala Pro Ser Asp Glu Ala Tyr Ala Ile Leu Pro Val Asp 
            100                 105                 110         


Gly Gln Gly Val Ala Val Val Ser Arg Thr Pro Ala Gly Val Leu Tyr 
        115                 120                 125             


Gly Val Phe His Leu Ile Arg Arg Leu Arg Leu Gly Glu Pro Leu His 
    130                 135                 140                 


Glu Pro Cys Val Ser Ser Pro Lys Asn Ala Trp Arg Met Leu Asp His 
145                 150                 155                 160 


Trp Asp Asn Ala Asp Gly Thr Ile Glu Arg Gly Tyr Ala Gly Lys Ser 
                165                 170                 175     


Leu Phe Tyr Arg Gly Gly Gln Ile Asp Phe Asp Glu Gly Arg Val Arg 
            180                 185                 190         


Asp Tyr Ala Arg Leu Leu Ala Ser Val Gly Val Asn Ala Ile Ala Ile 
        195                 200                 205             


Asn Asn Val Asn Val His Glu Thr Glu Thr Arg Phe Leu Thr Glu Ala 
    210                 215                 220                 


His Leu Pro Gly Val Ala Arg Leu Ala Asp Val Phe Arg Pro Tyr Gly 
225                 230                 235                 240 


Ile Arg Val Phe Leu Ser Ile Asn Phe Ala Ser Pro Val Asp Leu Gly 
                245                 250                 255     


Asp Leu Pro Thr Ala Asp Pro Leu Asp Pro Arg Val Glu Asp Trp Trp 
            260                 265                 270         


Arg Ala Thr Ala Asp Arg Ile Tyr Arg His Ile Pro Asp Phe Gly Gly 
        275                 280                 285             


Phe Leu Val Lys Ala Asp Ser Glu Phe Arg Pro Gly Pro Phe Thr Tyr 
    290                 295                 300                 


Gly Arg Asp His Ala Asp Gly Ala Asn Met Leu Ala Arg Ala Leu Ala 
305                 310                 315                 320 


Pro His Gly Gly Val Val Ile Trp Arg Ala Phe Val Tyr Asn Cys Leu 
                325                 330                 335     


Met Asp Trp Arg Asp Arg Arg Ala Asp Arg Ala Arg Ala Ala Tyr Asp 
            340                 345                 350         


His Phe Val Pro Leu Asp Gly Arg Phe Leu Asp Asn Val Leu Ile Gln 
        355                 360                 365             


Ile Lys Asn Gly Pro Met Asp Phe Gln Val Arg Glu Pro Val Ser Pro 
    370                 375                 380                 


Leu Phe Gly Gly Leu Ser Ala Thr Asn Val Met Leu Glu Phe Gln Ile 
385                 390                 395                 400 


Thr Gln Glu Tyr Thr Gly Gln Gln Arg His Val Cys Tyr Leu Ala Pro 
                405                 410                 415     


Met Trp Lys Glu Val Leu Asp Phe Asp Thr His Ala Arg Gly Pro Gly 
            420                 425                 430         


Ser Thr Val Ala Glu Ile Ala Ser Gly Arg Leu Phe Gly Arg Pro His 
        435                 440                 445             


Gly Gly Val Ala Gly Val Ala Asn Val Gly Asp Asp Val Asn Trp Thr 
    450                 455                 460                 


Gly His Ser Leu Ala Gln Ala Asn Leu Tyr Ala Phe Gly Arg Leu Ala 
465                 470                 475                 480 


Trp Asp Pro Ser Leu Asp Pro Ala Gly Ile Ala Arg Glu Trp Ala Arg 
                485                 490                 495     


Leu Thr Tyr Gly Asp Asp Pro Asp Val Val Arg Thr Val Val Gly Ile 
            500                 505                 510         


Leu Met Ala Ser Trp Pro Ala Tyr Glu Ala Tyr Thr Ala Pro Leu Gly 
        515                 520                 525             


Val Gly Trp Met Val Asn Pro Gly His His Asp Gly Pro Asn Pro Glu 
    530                 535                 540                 


Gly Tyr Glu Tyr Ser Lys Trp Gly Thr Tyr His Tyr Ala Asp Trp Arg 
545                 550                 555                 560 


Gly Val Gly Val Asp Arg Thr Met Ala Thr Gly Thr Gly Tyr Thr Gly 
                565                 570                 575     


Gln Tyr His Glu Pro Met Arg Ser Leu Tyr Glu His Leu Glu Thr Cys 
            580                 585                 590         


Pro Asp Glu Leu Leu Leu Phe Phe His His Val Pro Tyr Thr His Val 
        595                 600                 605             


Leu His Ser Gly Lys Thr Val Ile Gln His Ile Tyr Asp Ala His Phe 
    610                 615                 620                 


Asp Gly Val Glu Ala Val Ala Trp Met Ile Glu Ala Trp Arg Arg Leu 
625                 630                 635                 640 


Gln Gly Arg Ile Asp Pro Val Arg Phe Glu Arg Val Leu Ala Arg Leu 
                645                 650                 655     


Glu Asp Gln Met Gln Arg Ala Val Glu Trp Arg Asp Val Ile Asn Thr 
            660                 665                 670         


Tyr Phe Tyr Arg Lys Cys Gly Ile Pro Asp Ala Arg Gly Leu His Ile 
        675                 680                 685             


Tyr Pro 
    690 


<210>  349
<211>  690
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:337 and encoded by SEQ ID NO:344

<400>  349

Met Thr Asn Val Pro Glu Gly Asp Leu Asp Tyr Arg Ala Trp Leu Gln 
1               5                   10                  15      


Glu Ser Pro Leu Pro Arg Ala Val Pro Glu Ala Ala Arg Arg Met Ala 
            20                  25                  30          


Val Tyr Gly Pro Ala Asp Asp Pro Leu Leu Cys Thr Ala Ala Ala Glu 
        35                  40                  45              


Trp Gly Arg Ala Val Arg Ala Ala Cys Gly Glu Ser Pro Ala Arg Leu 
    50                  55                  60                  


Ala Arg Asp Pro Gly Gly Ala Pro Ser Val Pro Cys Val Ala Met Gly 
65                  70                  75                  80  


Leu Leu Ser Ala Met Pro Arg Gly Leu Arg Glu Ala Ala Gln Ala Ala 
                85                  90                  95      


Leu Ala Gly Ala Pro Ser Asp Glu Ala Tyr Ala Ile Leu Pro Val Asp 
            100                 105                 110         


Gly Gln Gly Val Ala Val Val Ser Arg Thr Pro Ala Gly Val Leu Tyr 
        115                 120                 125             


Gly Val Phe His Leu Ile Arg Arg Leu Arg Leu Gly Glu Pro Leu His 
    130                 135                 140                 


Glu Pro Cys Val Ser Ser Pro Lys Asn Ala Trp Arg Met Leu Asp His 
145                 150                 155                 160 


Trp Asp Asn Ala Asp Gly Thr Ile Glu Arg Gly Tyr Ala Gly Lys Ser 
                165                 170                 175     


Leu Phe Tyr Arg Gly Gly Gln Ile Asp Phe Asp Glu Gly Arg Val Arg 
            180                 185                 190         


Asp Tyr Ala Arg Leu Leu Ala Ser Val Gly Val Asn Ala Ile Ala Ile 
        195                 200                 205             


Asn Asn Val Asn Val His Glu Thr Glu Thr Arg Phe Leu Thr Glu Ala 
    210                 215                 220                 


His Leu Pro Gly Val Ala Arg Leu Ala Asp Val Phe Arg Pro Tyr Gly 
225                 230                 235                 240 


Ile Arg Val Phe Leu Ser Ile Asn Phe Ala Ser Pro Val Asp Leu Gly 
                245                 250                 255     


Asp Leu Pro Thr Ala Asp Pro Leu Asp Pro Arg Val Glu Asp Trp Trp 
            260                 265                 270         


Arg Ala Thr Ala Asp Arg Ile Tyr Arg His Ile Pro Asp Phe Gly Gly 
        275                 280                 285             


Phe Leu Val Lys Ala Asp Ser Glu Phe Arg Pro Gly Pro Phe Thr Tyr 
    290                 295                 300                 


Gly Arg Asp His Ala Asp Gly Ala Asn Met Leu Ala Arg Ala Leu Ala 
305                 310                 315                 320 


Pro His Gly Gly Val Val Ile Trp Arg Ala Phe Val Tyr Asn Cys Leu 
                325                 330                 335     


Met Asp Trp Arg Asp Arg Arg Ala Asp Arg Ala Arg Ala Ala Tyr Asp 
            340                 345                 350         


His Phe Val Pro Leu Asp Gly Arg Phe Leu Asp Asn Val Leu Ile Gln 
        355                 360                 365             


Ile Lys Asn Gly Pro Met Asp Phe Gln Val Arg Glu Pro Val Ser Pro 
    370                 375                 380                 


Leu Phe Gly Gly Leu Ser Ala Thr Asn Val Met Leu Glu Phe Gln Ile 
385                 390                 395                 400 


Thr Gln Glu Tyr Thr Gly Gln Gln Arg His Val Cys Tyr Leu Ala Pro 
                405                 410                 415     


Met Trp Lys Glu Val Leu Asp Phe Asp Thr His Ala Arg Gly Pro Gly 
            420                 425                 430         


Ser Thr Val Ala Glu Ile Ala Ser Gly Arg Leu Phe Gly Arg Pro His 
        435                 440                 445             


Gly Gly Val Ala Gly Val Ala Asn Val Gly Asp Asp Val Asn Trp Thr 
    450                 455                 460                 


Gly His Ser Leu Ala Gln Ala Asn Leu Tyr Ala Phe Gly Arg Leu Ala 
465                 470                 475                 480 


Trp Asp Pro Ser Leu Asp Pro Ala Gly Ile Ala Arg Glu Trp Ala Arg 
                485                 490                 495     


Leu Thr Tyr Gly Asp Asp Pro Asp Val Val Arg Thr Val Val Gly Ile 
            500                 505                 510         


Leu Met Ala Ser Trp Pro Ala Tyr Glu Ala Tyr Thr Ala Pro Leu Gly 
        515                 520                 525             


Val Gly Trp Met Val Asn Pro Gly His His Asp Gly Pro Asn Pro Glu 
    530                 535                 540                 


Gly Tyr Glu Tyr Ser Lys Trp Gly Thr Tyr His Tyr Ala Asp Trp Arg 
545                 550                 555                 560 


Gly Val Gly Val Asp Arg Thr Met Ala Thr Gly Thr Gly Tyr Thr Gly 
                565                 570                 575     


Gln Tyr His Glu Pro Met Arg Ser Leu Tyr Glu His Leu Glu Thr Cys 
            580                 585                 590         


Pro Asp Glu Leu Leu Leu Phe Phe His His Val Pro Tyr Thr His Val 
        595                 600                 605             


Leu His Ser Gly Lys Thr Val Ile Gln His Ile Tyr Asp Ala His Phe 
    610                 615                 620                 


Asp Gly Val Glu Ala Val Ala Trp Met Ile Glu Ala Trp Arg Arg Leu 
625                 630                 635                 640 


Gln Gly Arg Ile Asp Pro Val Arg Phe Glu Arg Val Leu Ala Arg Leu 
                645                 650                 655     


Glu Asp Gln Met Gln Arg Ala Val Glu Trp Arg Asp Val Ile Asn Thr 
            660                 665                 670         


Tyr Phe Tyr Arg Lys Cys Gly Ile Pro Asp Ala Arg Gly Leu His Ile 
        675                 680                 685             


Tyr Pro 
    690 


<210>  350
<211>  690
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:337 and encoded by SEQ ID NO:345

<400>  350

Met Thr Asn Leu Pro Glu Gly Asp Leu Asp Tyr Arg Ala Trp Leu Gln 
1               5                   10                  15      


Glu Ser Pro Leu Pro Arg Ala Val Pro Glu Ala Ala Arg Arg Met Ala 
            20                  25                  30          


Val Tyr Gly Pro Ala Asp Asp Pro Leu Leu Cys Thr Ala Ala Ala Glu 
        35                  40                  45              


Trp Gly Arg Ala Val Arg Ala Ala Cys Gly Glu Ser Pro Ala Arg Leu 
    50                  55                  60                  


Ala Arg Asp Pro Gly Gly Ala Pro Ser Val Pro Cys Val Ala Met Gly 
65                  70                  75                  80  


Leu Leu Ser Ala Met Pro Arg Gly Leu Arg Glu Ala Ala Gln Ala Ala 
                85                  90                  95      


Leu Ala Gly Ala Pro Ser Asp Glu Ala Tyr Ala Ile Leu Pro Val Asp 
            100                 105                 110         


Gly Gln Gly Val Ala Val Val Ser Arg Thr Pro Ala Gly Val Leu Tyr 
        115                 120                 125             


Gly Val Phe His Leu Ile Arg Arg Leu Arg Leu Gly Glu Pro Leu His 
    130                 135                 140                 


Glu Pro Cys Val Ser Ser Pro Lys Asn Ala Trp Arg Met Leu Asp His 
145                 150                 155                 160 


Trp Asp Asn Ala Asp Gly Thr Ile Glu Arg Gly Tyr Ala Gly Lys Ser 
                165                 170                 175     


Leu Phe Tyr Arg Gly Gly Gln Ile Asp Phe Asp Glu Gly Arg Val Arg 
            180                 185                 190         


Asp Tyr Ala Arg Leu Leu Ala Ser Val Gly Val Asn Ala Ile Ala Ile 
        195                 200                 205             


Asn Asn Val Asn Val His Glu Thr Glu Thr Arg Phe Leu Thr Glu Ala 
    210                 215                 220                 


His Leu Pro Gly Val Ala Arg Leu Ala Asp Val Phe Arg Pro Tyr Gly 
225                 230                 235                 240 


Ile Arg Val Phe Leu Ser Ile Asn Phe Ala Ser Pro Val Asp Leu Gly 
                245                 250                 255     


Asp Leu Pro Thr Ala Asp Pro Leu Asp Pro Arg Val Glu Asp Trp Trp 
            260                 265                 270         


Arg Ala Thr Ala Asp Arg Ile Tyr Arg His Ile Pro Asp Phe Gly Gly 
        275                 280                 285             


Phe Leu Val Lys Ala Asp Ser Glu Phe Arg Pro Gly Pro Phe Thr Tyr 
    290                 295                 300                 


Gly Arg Asp His Ala Asp Gly Ala Asn Met Leu Ala Arg Ala Leu Ala 
305                 310                 315                 320 


Pro His Gly Gly Val Val Ile Trp Arg Ala Phe Val Tyr Asn Cys Leu 
                325                 330                 335     


Met Asp Trp Arg Asp Arg Arg Ala Asp Arg Ala Arg Ala Ala Tyr Asp 
            340                 345                 350         


His Phe Val Pro Leu Asp Gly Arg Phe Leu Asp Asn Val Leu Ile Gln 
        355                 360                 365             


Ile Lys Asn Gly Pro Met Asp Phe Gln Val Arg Glu Pro Val Ser Pro 
    370                 375                 380                 


Leu Phe Gly Gly Leu Ser Ala Thr Asn Val Met Leu Glu Phe Gln Ile 
385                 390                 395                 400 


Thr Gln Glu Tyr Thr Gly Gln Gln Arg His Val Cys Tyr Leu Ala Pro 
                405                 410                 415     


Met Trp Lys Glu Val Leu Asp Phe Asp Thr His Ala Arg Gly Pro Gly 
            420                 425                 430         


Ser Thr Val Ala Glu Ile Ala Ser Gly Arg Leu Phe Gly Arg Pro His 
        435                 440                 445             


Gly Gly Val Ala Gly Val Ala Asn Val Gly Asp Asp Val Asn Trp Thr 
    450                 455                 460                 


Gly His Ser Leu Ala Gln Ala Asn Leu Tyr Ala Phe Gly Arg Leu Ala 
465                 470                 475                 480 


Trp Asp Pro Ser Leu Asp Pro Ala Gly Ile Ala Arg Glu Trp Ala Arg 
                485                 490                 495     


Leu Thr Tyr Gly Asp Asp Pro Asp Val Val Arg Thr Val Val Gly Ile 
            500                 505                 510         


Leu Met Ala Ser Trp Pro Ala Tyr Glu Ala Tyr Thr Ala Pro Leu Gly 
        515                 520                 525             


Val Gly Trp Met Val Asn Pro Gly His His Asp Gly Pro Asn Pro Glu 
    530                 535                 540                 


Gly Tyr Glu Tyr Ser Lys Trp Gly Thr Tyr His Tyr Ala Asp Trp Arg 
545                 550                 555                 560 


Gly Val Gly Val Asp Arg Thr Met Ala Thr Gly Thr Gly Tyr Thr Gly 
                565                 570                 575     


Gln Tyr His Glu Pro Met Arg Ser Leu Tyr Glu His Leu Glu Thr Cys 
            580                 585                 590         


Pro Asp Glu Leu Leu Leu Phe Phe His His Val Pro Tyr Thr His Val 
        595                 600                 605             


Leu His Ser Gly Lys Thr Val Ile Gln His Ile Tyr Asp Ala His Phe 
    610                 615                 620                 


Asp Gly Val Glu Ala Val Ala Trp Met Ile Glu Ala Trp Arg Arg Leu 
625                 630                 635                 640 


Gln Gly Arg Ile Asp Pro Val Arg Phe Glu Arg Val Leu Ala Arg Leu 
                645                 650                 655     


Glu Asp Gln Met Gln Arg Ala Val Glu Trp Arg Asp Val Ile Asn Thr 
            660                 665                 670         


Tyr Phe Tyr Arg Lys Cys Gly Ile Pro Asp Ala Arg Gly Leu His Ile 
        675                 680                 685             


Tyr Pro 
    690 


<210>  351
<211>  690
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:337 and encoded by SEQ ID NO:346

<400>  351

Met Thr Asn Ile Pro Asp Gly Asp Leu Asp Tyr Arg Ala Trp Leu Gln 
1               5                   10                  15      


Glu Ser Pro Leu Pro Arg Ala Val Pro Glu Ala Ala Arg Arg Met Ala 
            20                  25                  30          


Val Tyr Gly Pro Ala Asp Asp Pro Leu Leu Cys Thr Ala Ala Ala Glu 
        35                  40                  45              


Trp Gly Arg Ala Val Arg Ala Ala Cys Gly Glu Ser Pro Ala Arg Leu 
    50                  55                  60                  


Ala Arg Asp Pro Gly Gly Ala Pro Ser Val Pro Cys Val Ala Met Gly 
65                  70                  75                  80  


Leu Leu Ser Ala Met Pro Arg Gly Leu Arg Glu Ala Ala Gln Ala Ala 
                85                  90                  95      


Leu Ala Gly Ala Pro Ser Asp Glu Ala Tyr Ala Ile Leu Pro Val Asp 
            100                 105                 110         


Gly Gln Gly Val Ala Val Val Ser Arg Thr Pro Ala Gly Val Leu Tyr 
        115                 120                 125             


Gly Val Phe His Leu Ile Arg Arg Leu Arg Leu Gly Glu Pro Leu His 
    130                 135                 140                 


Glu Pro Cys Val Ser Ser Pro Lys Asn Ala Trp Arg Met Leu Asp His 
145                 150                 155                 160 


Trp Asp Asn Ala Asp Gly Thr Ile Glu Arg Gly Tyr Ala Gly Lys Ser 
                165                 170                 175     


Leu Phe Tyr Arg Gly Gly Gln Ile Asp Phe Asp Glu Gly Arg Val Arg 
            180                 185                 190         


Asp Tyr Ala Arg Leu Leu Ala Ser Val Gly Val Asn Ala Ile Ala Ile 
        195                 200                 205             


Asn Asn Val Asn Val His Glu Thr Glu Thr Arg Phe Leu Thr Glu Ala 
    210                 215                 220                 


His Leu Pro Gly Val Ala Arg Leu Ala Asp Val Phe Arg Pro Tyr Gly 
225                 230                 235                 240 


Ile Arg Val Phe Leu Ser Ile Asn Phe Ala Ser Pro Val Asp Leu Gly 
                245                 250                 255     


Asp Leu Pro Thr Ala Asp Pro Leu Asp Pro Arg Val Glu Asp Trp Trp 
            260                 265                 270         


Arg Ala Thr Ala Asp Arg Ile Tyr Arg His Ile Pro Asp Phe Gly Gly 
        275                 280                 285             


Phe Leu Val Lys Ala Asp Ser Glu Phe Arg Pro Gly Pro Phe Thr Tyr 
    290                 295                 300                 


Gly Arg Asp His Ala Asp Gly Ala Asn Met Leu Ala Arg Ala Leu Ala 
305                 310                 315                 320 


Pro His Gly Gly Val Val Ile Trp Arg Ala Phe Val Tyr Asn Cys Leu 
                325                 330                 335     


Met Asp Trp Arg Asp Arg Arg Ala Asp Arg Ala Arg Ala Ala Tyr Asp 
            340                 345                 350         


His Phe Val Pro Leu Asp Gly Arg Phe Leu Asp Asn Val Leu Ile Gln 
        355                 360                 365             


Ile Lys Asn Gly Pro Met Asp Phe Gln Val Arg Glu Pro Val Ser Pro 
    370                 375                 380                 


Leu Phe Gly Gly Leu Ser Ala Thr Asn Val Met Leu Glu Phe Gln Ile 
385                 390                 395                 400 


Thr Gln Glu Tyr Thr Gly Gln Gln Arg His Val Cys Tyr Leu Ala Pro 
                405                 410                 415     


Met Trp Lys Glu Val Leu Asp Phe Asp Thr His Ala Arg Gly Pro Gly 
            420                 425                 430         


Ser Thr Val Ala Glu Ile Ala Ser Gly Arg Leu Phe Gly Arg Pro His 
        435                 440                 445             


Gly Gly Val Ala Gly Val Ala Asn Val Gly Asp Asp Val Asn Trp Thr 
    450                 455                 460                 


Gly His Ser Leu Ala Gln Ala Asn Leu Tyr Ala Phe Gly Arg Leu Ala 
465                 470                 475                 480 


Trp Asp Pro Ser Leu Asp Pro Ala Gly Ile Ala Arg Glu Trp Ala Arg 
                485                 490                 495     


Leu Thr Tyr Gly Asp Asp Pro Asp Val Val Arg Thr Val Val Gly Ile 
            500                 505                 510         


Leu Met Ala Ser Trp Pro Ala Tyr Glu Ala Tyr Thr Ala Pro Leu Gly 
        515                 520                 525             


Val Gly Trp Met Val Asn Pro Gly His His Asp Gly Pro Asn Pro Glu 
    530                 535                 540                 


Gly Tyr Glu Tyr Ser Lys Trp Gly Thr Tyr His Tyr Ala Asp Trp Arg 
545                 550                 555                 560 


Gly Val Gly Val Asp Arg Thr Met Ala Thr Gly Thr Gly Tyr Thr Gly 
                565                 570                 575     


Gln Tyr His Glu Pro Met Arg Ser Leu Tyr Glu His Leu Glu Thr Cys 
            580                 585                 590         


Pro Asp Glu Leu Leu Leu Phe Phe His His Val Pro Tyr Thr His Val 
        595                 600                 605             


Leu His Ser Gly Lys Thr Val Ile Gln His Ile Tyr Asp Ala His Phe 
    610                 615                 620                 


Asp Gly Val Glu Ala Val Ala Trp Met Ile Glu Ala Trp Arg Arg Leu 
625                 630                 635                 640 


Gln Gly Arg Ile Asp Pro Val Arg Phe Glu Arg Val Leu Ala Arg Leu 
                645                 650                 655     


Glu Asp Gln Met Gln Arg Ala Val Glu Trp Arg Asp Val Ile Asn Thr 
            660                 665                 670         


Tyr Phe Tyr Arg Lys Cys Gly Ile Pro Asp Ala Arg Gly Leu His Ile 
        675                 680                 685             


Tyr Pro 
    690 


<210>  352
<211>  690
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:337 and encoded by SEQ ID NO:347

<400>  352

Met Thr Asn Ile Pro Glu Gly Glu Leu Asp Tyr Arg Ala Trp Leu Gln 
1               5                   10                  15      


Glu Ser Pro Leu Pro Arg Ala Val Pro Glu Ala Ala Arg Arg Met Ala 
            20                  25                  30          


Val Tyr Gly Pro Ala Asp Asp Pro Leu Leu Cys Thr Ala Ala Ala Glu 
        35                  40                  45              


Trp Gly Arg Ala Val Arg Ala Ala Cys Gly Glu Ser Pro Ala Arg Leu 
    50                  55                  60                  


Ala Arg Asp Pro Gly Gly Ala Pro Ser Val Pro Cys Val Ala Met Gly 
65                  70                  75                  80  


Leu Leu Ser Ala Met Pro Arg Gly Leu Arg Glu Ala Ala Gln Ala Ala 
                85                  90                  95      


Leu Ala Gly Ala Pro Ser Asp Glu Ala Tyr Ala Ile Leu Pro Val Asp 
            100                 105                 110         


Gly Gln Gly Val Ala Val Val Ser Arg Thr Pro Ala Gly Val Leu Tyr 
        115                 120                 125             


Gly Val Phe His Leu Ile Arg Arg Leu Arg Leu Gly Glu Pro Leu His 
    130                 135                 140                 


Glu Pro Cys Val Ser Ser Pro Lys Asn Ala Trp Arg Met Leu Asp His 
145                 150                 155                 160 


Trp Asp Asn Ala Asp Gly Thr Ile Glu Arg Gly Tyr Ala Gly Lys Ser 
                165                 170                 175     


Leu Phe Tyr Arg Gly Gly Gln Ile Asp Phe Asp Glu Gly Arg Val Arg 
            180                 185                 190         


Asp Tyr Ala Arg Leu Leu Ala Ser Val Gly Val Asn Ala Ile Ala Ile 
        195                 200                 205             


Asn Asn Val Asn Val His Glu Thr Glu Thr Arg Phe Leu Thr Glu Ala 
    210                 215                 220                 


His Leu Pro Gly Val Ala Arg Leu Ala Asp Val Phe Arg Pro Tyr Gly 
225                 230                 235                 240 


Ile Arg Val Phe Leu Ser Ile Asn Phe Ala Ser Pro Val Asp Leu Gly 
                245                 250                 255     


Asp Leu Pro Thr Ala Asp Pro Leu Asp Pro Arg Val Glu Asp Trp Trp 
            260                 265                 270         


Arg Ala Thr Ala Asp Arg Ile Tyr Arg His Ile Pro Asp Phe Gly Gly 
        275                 280                 285             


Phe Leu Val Lys Ala Asp Ser Glu Phe Arg Pro Gly Pro Phe Thr Tyr 
    290                 295                 300                 


Gly Arg Asp His Ala Asp Gly Ala Asn Met Leu Ala Arg Ala Leu Ala 
305                 310                 315                 320 


Pro His Gly Gly Val Val Ile Trp Arg Ala Phe Val Tyr Asn Cys Leu 
                325                 330                 335     


Met Asp Trp Arg Asp Arg Arg Ala Asp Arg Ala Arg Ala Ala Tyr Asp 
            340                 345                 350         


His Phe Val Pro Leu Asp Gly Arg Phe Leu Asp Asn Val Leu Ile Gln 
        355                 360                 365             


Ile Lys Asn Gly Pro Met Asp Phe Gln Val Arg Glu Pro Val Ser Pro 
    370                 375                 380                 


Leu Phe Gly Gly Leu Ser Ala Thr Asn Val Met Leu Glu Phe Gln Ile 
385                 390                 395                 400 


Thr Gln Glu Tyr Thr Gly Gln Gln Arg His Val Cys Tyr Leu Ala Pro 
                405                 410                 415     


Met Trp Lys Glu Val Leu Asp Phe Asp Thr His Ala Arg Gly Pro Gly 
            420                 425                 430         


Ser Thr Val Ala Glu Ile Ala Ser Gly Arg Leu Phe Gly Arg Pro His 
        435                 440                 445             


Gly Gly Val Ala Gly Val Ala Asn Val Gly Asp Asp Val Asn Trp Thr 
    450                 455                 460                 


Gly His Ser Leu Ala Gln Ala Asn Leu Tyr Ala Phe Gly Arg Leu Ala 
465                 470                 475                 480 


Trp Asp Pro Ser Leu Asp Pro Ala Gly Ile Ala Arg Glu Trp Ala Arg 
                485                 490                 495     


Leu Thr Tyr Gly Asp Asp Pro Asp Val Val Arg Thr Val Val Gly Ile 
            500                 505                 510         


Leu Met Ala Ser Trp Pro Ala Tyr Glu Ala Tyr Thr Ala Pro Leu Gly 
        515                 520                 525             


Val Gly Trp Met Val Asn Pro Gly His His Asp Gly Pro Asn Pro Glu 
    530                 535                 540                 


Gly Tyr Glu Tyr Ser Lys Trp Gly Thr Tyr His Tyr Ala Asp Trp Arg 
545                 550                 555                 560 


Gly Val Gly Val Asp Arg Thr Met Ala Thr Gly Thr Gly Tyr Thr Gly 
                565                 570                 575     


Gln Tyr His Glu Pro Met Arg Ser Leu Tyr Glu His Leu Glu Thr Cys 
            580                 585                 590         


Pro Asp Glu Leu Leu Leu Phe Phe His His Val Pro Tyr Thr His Val 
        595                 600                 605             


Leu His Ser Gly Lys Thr Val Ile Gln His Ile Tyr Asp Ala His Phe 
    610                 615                 620                 


Asp Gly Val Glu Ala Val Ala Trp Met Ile Glu Ala Trp Arg Arg Leu 
625                 630                 635                 640 


Gln Gly Arg Ile Asp Pro Val Arg Phe Glu Arg Val Leu Ala Arg Leu 
                645                 650                 655     


Glu Asp Gln Met Gln Arg Ala Val Glu Trp Arg Asp Val Ile Asn Thr 
            660                 665                 670         


Tyr Phe Tyr Arg Lys Cys Gly Ile Pro Asp Ala Arg Gly Leu His Ile 
        675                 680                 685             


Tyr Pro 
    690 


<210>  353
<211>  1071
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  353
atggacagcg tcttgtttcg ccagacaggt acggtggctt ggctcgggct caaccggccg     60

aagcagttga acgcgctcag tctcgagatg atccgccttc ttcgtcgcca tttggacgag    120

atggcacaag atccatccgt ggaactcgtg gtgctgtacg gcgaaggcga ccgcgccttc    180

tgcgccggcg gcgacattcg ggcgctgtac gacgcgaagg atgagccaaa cctcgagacc    240

gcggccgcgt ttttctcaga ggagtacgcg ctcgacgatc gcgtcgcgcg gtttccaaag    300

cctgttgtcg ccttgtggga cggcatcgtg atggggggcg gggtcgggct cacctatggc    360

gcgacgtgga aggtcgcgac ggatcgcacg cggttcgcga tgcccgagac cgggattggc    420

ttctttccgg acgtcggcat gtgtcatgcg ctcagccgaa tgcagggcgg gctcggacac    480

tatctggcgc tcaccggcga gtccgttggc gccgatgtgc tcctcgcggc ggggctggcc    540

aacggctggc ttccgagcgg cgagcggccg tcgttcgagg cggaacttgt gaagcggggc    600

gaacagggag aaaccgcgga acaacttcag aggtggttgg ctgcaaggct ggccgtagag    660

caccggccat cggaggcggt cgcggacttt ctccggcggg tgcaggcgta tttcgacagc    720

ccgtcgctct ccgacatctt ggcgcgcttg cgggagggat cctcgcgcga tccgtttgcc    780

gcacaggcgc tcgagatcct gcgccagcgc tcgccgctct cgttggcggt gaccttcgag    840

gcgctccgcc gcgcagggaa cgcgacgtac cgcgaggtcc tagagaccga tctcaccctc    900

gccctccagt tcatccgccg gggcgacttt gtcgaagggg tgcgcgccca gctcgtcgac    960

aaggaccggc gccccaggtg gcgccacgcc gatctggcga gcgtgacggc cgaagaagtg   1020

gaggcatttt ttgaacccat tgcccatctt tccattccgt ttgccgattg a            1071


<210>  354
<211>  356
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  354

Met Asp Ser Val Leu Phe Arg Gln Thr Gly Thr Val Ala Trp Leu Gly 
1               5                   10                  15      


Leu Asn Arg Pro Lys Gln Leu Asn Ala Leu Ser Leu Glu Met Ile Arg 
            20                  25                  30          


Leu Leu Arg Arg His Leu Asp Glu Met Ala Gln Asp Pro Ser Val Glu 
        35                  40                  45              


Leu Val Val Leu Tyr Gly Glu Gly Asp Arg Ala Phe Cys Ala Gly Gly 
    50                  55                  60                  


Asp Ile Arg Ala Leu Tyr Asp Ala Lys Asp Glu Pro Asn Leu Glu Thr 
65                  70                  75                  80  


Ala Ala Ala Phe Phe Ser Glu Glu Tyr Ala Leu Asp Asp Arg Val Ala 
                85                  90                  95      


Arg Phe Pro Lys Pro Val Val Ala Leu Trp Asp Gly Ile Val Met Gly 
            100                 105                 110         


Gly Gly Val Gly Leu Thr Tyr Gly Ala Thr Trp Lys Val Ala Thr Asp 
        115                 120                 125             


Arg Thr Arg Phe Ala Met Pro Glu Thr Gly Ile Gly Phe Phe Pro Asp 
    130                 135                 140                 


Val Gly Met Cys His Ala Leu Ser Arg Met Gln Gly Gly Leu Gly His 
145                 150                 155                 160 


Tyr Leu Ala Leu Thr Gly Glu Ser Val Gly Ala Asp Val Leu Leu Ala 
                165                 170                 175     


Ala Gly Leu Ala Asn Gly Trp Leu Pro Ser Gly Glu Arg Pro Ser Phe 
            180                 185                 190         


Glu Ala Glu Leu Val Lys Arg Gly Glu Gln Gly Glu Thr Ala Glu Gln 
        195                 200                 205             


Leu Gln Arg Trp Leu Ala Ala Arg Leu Ala Val Glu His Arg Pro Ser 
    210                 215                 220                 


Glu Ala Val Ala Asp Phe Leu Arg Arg Val Gln Ala Tyr Phe Asp Ser 
225                 230                 235                 240 


Pro Ser Leu Ser Asp Ile Leu Ala Arg Leu Arg Glu Gly Ser Ser Arg 
                245                 250                 255     


Asp Pro Phe Ala Ala Gln Ala Leu Glu Ile Leu Arg Gln Arg Ser Pro 
            260                 265                 270         


Leu Ser Leu Ala Val Thr Phe Glu Ala Leu Arg Arg Ala Gly Asn Ala 
        275                 280                 285             


Thr Tyr Arg Glu Val Leu Glu Thr Asp Leu Thr Leu Ala Leu Gln Phe 
    290                 295                 300                 


Ile Arg Arg Gly Asp Phe Val Glu Gly Val Arg Ala Gln Leu Val Asp 
305                 310                 315                 320 


Lys Asp Arg Arg Pro Arg Trp Arg His Ala Asp Leu Ala Ser Val Thr 
                325                 330                 335     


Ala Glu Glu Val Glu Ala Phe Phe Glu Pro Ile Ala His Leu Ser Ile 
            340                 345                 350         


Pro Phe Ala Asp 
        355     


<210>  355
<211>  353
<212>  PRT
<213>  Bacillus licheniformis

<400>  355

Met Ser Asp Asp Val Leu Phe Ser Val Asn Gln Asn Gly Ala Ala Ala 
1               5                   10                  15      


Ile Val Leu Asn Arg Pro Lys Ala Leu Asn Ser Leu Thr Tyr Asp Met 
            20                  25                  30          


Val Arg Leu Ile Gly Glu Lys Leu Asn Glu Trp Glu Thr Asp Gln Asn 
        35                  40                  45              


Val Ser Ile Val Val Ile Lys Gly Ala Gly Pro Lys Gly Leu Cys Ala 
    50                  55                  60                  


Gly Gly Asp Ile Lys Ala Leu Tyr Glu Ala Arg Ser Ser Lys Gln Ala 
65                  70                  75                  80  


Leu Gln Asp Ala Glu Arg Phe Phe Glu Thr Glu Tyr Glu Val Asp Met 
                85                  90                  95      


Ala Val His Arg Phe Ser Lys Pro Ile Ile Ala Cys Leu Asp Gly Ile 
            100                 105                 110         


Val Met Gly Gly Gly Val Gly Leu Thr Tyr Gly Ala Ser His Arg Ile 
        115                 120                 125             


Val Thr Glu Arg Thr Lys Trp Ala Met Pro Glu Met Asn Ile Gly Phe 
    130                 135                 140                 


Phe Pro Asp Val Gly Ala Ala Tyr Phe Leu Asn Lys Ala Pro Gly Arg 
145                 150                 155                 160 


Leu Gly Arg Tyr Leu Gly Leu Thr Ala Ser Val Ile His Ala Ala Asp 
                165                 170                 175     


Val Leu Tyr Ile Asn Gly Ala Asp Ala Tyr Met Glu Ser Gly Ala Leu 
            180                 185                 190         


Glu Arg Leu Leu Gln Ala Val Glu Gln Thr Asp Trp Arg Leu Ala Ser 
        195                 200                 205             


Val Glu Glu Lys Leu Asp Gln Leu Ile Arg Glu Ser Lys Thr Glu Pro 
    210                 215                 220                 


Ser Gln Glu Ser Thr Leu Ala Arg Asp Gln Gln Ala Ile Asp Arg His 
225                 230                 235                 240 


Phe Lys Tyr Asp Lys Leu Glu Glu Ile Leu Gln Ser Leu Glu Ser Glu 
                245                 250                 255     


Gly Ser Thr Phe Ser Ser Asn Val Lys Lys Thr Met Leu Ser Lys Ser 
            260                 265                 270         


Pro Phe Ser Leu Lys Ile Thr Leu Lys Gln Leu Ala Asp Gly Arg Gln 
        275                 280                 285             


Lys Thr Leu Glu Glu Cys Phe Ala Thr Asp Leu Val Leu Ala Lys Asn 
    290                 295                 300                 


Phe Leu Lys His Asn Asp Phe Phe Glu Gly Val Arg Ser Val Leu Ile 
305                 310                 315                 320 


Asp Arg Asp Gln Ser Pro Asn Tyr Lys Tyr Arg Asn Val Ser Asp Val 
                325                 330                 335     


Thr Asp Glu Ala Val Asp Arg Phe Phe Gln Pro Ser Glu Ser Val Arg 
            340                 345                 350         


Phe 
    


<210>  356
<211>  386
<212>  PRT
<213>  Caenorhabditis elegans

<400>  356

Met Ala Ala Thr Val Arg Asn Leu Pro Ala Leu Phe Arg Gly Leu His 
1               5                   10                  15      


Ser Lys Glu Val Cys Gln Lys Met Ser Phe Ser Val Ser Ala Ala Ala 
            20                  25                  30          


Lys Ser Glu Ile Leu Val Asp Thr His Gly Ser Lys Lys Val Val Thr 
        35                  40                  45              


Leu Asn Arg Pro Lys Ala Leu Asn Ala Leu Asn Leu Glu Met Val Arg 
    50                  55                  60                  


Glu Phe Tyr Pro Lys Leu Gln Ala Trp Asn Ser Ser Ser Asp Val Asp 
65                  70                  75                  80  


Leu Val Ile Leu Lys Gly Ser Gly Asp Lys Ala Phe Cys Ala Gly Gly 
                85                  90                  95      


Asp Val Leu Ala Val Val Arg Ser Phe Lys Asp Ser Glu Ser Gly Lys 
            100                 105                 110         


Glu Cys Thr Met His Lys Asp Phe Phe Arg Glu Glu Tyr Ile Leu Asn 
        115                 120                 125             


His Leu Ile Gly Thr Leu Asn Lys Gln Tyr Val Cys Leu Ile Asp Gly 
    130                 135                 140                 


Ile Val Met Gly Gly Gly Cys Gly Leu Ser Val Asn Gly Arg Phe Arg 
145                 150                 155                 160 


Val Ala Thr Glu Lys Thr Met Leu Ala Met Pro Glu Thr Ala Leu Gly 
                165                 170                 175     


Leu Phe Pro Asp Val Gly Gly Ser Tyr Phe Leu Ser Arg Leu Lys Gly 
            180                 185                 190         


Asn Leu Gly Met Tyr Leu Ala Leu Thr Gly Tyr Arg Leu Leu Gly Ala 
        195                 200                 205             


Asp Ala Phe His Ala Gly Leu Ala Thr His Phe Val Glu Ser Ser Glu 
    210                 215                 220                 


Leu Ala Lys Leu Glu Lys Glu Leu Val Asn Ile Lys Asp Val Thr Glu 
225                 230                 235                 240 


Asn Ser Val Asp Glu Val Ile Arg Ser Phe Glu Pro Lys Lys Ile Pro 
                245                 250                 255     


Glu Phe Ser Leu Ser Lys Asn Leu Ala Gln Ile Arg Asp Ser Phe Lys 
            260                 265                 270         


Ala Lys Ser Val Glu Glu Ile Leu Ala Ser Leu Glu Lys Asp Gly Ser 
        275                 280                 285             


Asp Trp Ala Lys Lys Gln Ala Ala Thr Leu Gly Lys Met Ser Pro Thr 
    290                 295                 300                 


Ser Leu Lys Val Thr His Arg Gln Ile Thr Glu Gly Ser Lys Met Ser 
305                 310                 315                 320 


Tyr Ala Lys Ile Phe Thr Met Glu Tyr Arg Leu Thr Gln Arg Phe Leu 
                325                 330                 335     


Ala Asp Lys Asp Phe His Glu Gly Cys Arg Ala Ile Leu Val Asp Lys 
            340                 345                 350         


Asp Arg Lys Pro Lys Trp Asn Pro Ala Thr Leu Ala Asp Val Lys Asp 
        355                 360                 365             


Ser Val Val Asp Asn Tyr Phe Ser Pro Leu Pro Asn Asn Ser Asp Leu 
    370                 375                 380                 


Lys Leu 
385     


<210>  357
<211>  385
<212>  PRT
<213>  Drosophila melanogaster

<400>  357

Met Gly Pro Ile Gln Arg Leu Val Tyr Thr Phe Gly His Arg Thr Cys 
1               5                   10                  15      


Ser Gln Leu Pro Met Ile Gly Gly Ala Thr Ile Ser Gln Thr Lys Pro 
            20                  25                  30          


Thr Thr Met Ala Leu Ser Val Arg Gln Ser Ser Ser Ser Val Leu Ala 
        35                  40                  45              


Thr Glu Ser Ser Asn Lys Gly Met Ile Ile Leu Asn Arg Pro Lys Ala 
    50                  55                  60                  


Leu Asn Ala Ile Asn Leu Glu Met Val Arg Lys Ile Tyr Lys His Leu 
65                  70                  75                  80  


Lys Lys Cys Glu Lys Ser Lys Ser Leu Val Ile Ile Lys Gly Thr Gly 
                85                  90                  95      


Asp Lys Ala Phe Cys Ala Gly Gly Asp Val Arg Ala Leu Val Glu Ala 
            100                 105                 110         


Gly Pro Thr Asp Glu Ser Lys Ser Phe Phe Arg Glu Glu Tyr Ser Thr 
        115                 120                 125             


Asn Ala Leu Ile Gly Asn Tyr Lys Ile Pro Tyr Ile Ala Ile Ile Asp 
    130                 135                 140                 


Gly Ile Thr Met Gly Gly Gly Val Gly Leu Ser Val His Gly Lys Tyr 
145                 150                 155                 160 


Arg Val Ala Ser Asp Arg Thr Leu Phe Ala Met Pro Glu Thr Ala Ile 
                165                 170                 175     


Gly Leu Phe Pro Asp Val Gly Gly Ser Tyr Phe Leu Pro Arg Leu Gln 
            180                 185                 190         


Gly Lys Leu Gly Leu Tyr Leu Gly Leu Thr Gly Tyr Arg Leu Arg Gly 
        195                 200                 205             


Ala Asp Val Tyr Tyr Ser Gly Ile Ala Thr His Tyr Cys Glu Ser Ser 
    210                 215                 220                 


Lys Ile Pro Asp Leu Glu Thr Ala Leu Leu Asn Cys Pro Asp Ala Asp 
225                 230                 235                 240 


Asp Val Pro Glu Leu Leu Gln Lys Tyr His Ser Pro Pro Glu Lys Pro 
                245                 250                 255     


Phe Ser Leu Gln Pro Val Leu Glu Gln Ile Asn Lys Asn Phe Ser Ala 
            260                 265                 270         


Asp Ser Val Glu Gly Ile Leu Glu Asn Leu Gln Asn Asp Gly Ser Glu 
        275                 280                 285             


Trp Ala Lys Lys Thr Leu Glu Thr Leu Ser Lys Met Ser Pro Thr Ser 
    290                 295                 300                 


Met Lys Val Thr Phe Arg Gln Leu Glu Leu Gly Ser Gln Leu Ser Leu 
305                 310                 315                 320 


Ala Gln Cys Leu Ile Met Glu Tyr Arg Leu Ala Val Arg His Leu Glu 
                325                 330                 335     


Arg Ser Asp Phe Lys Glu Gly Val Arg Ala Leu Leu Ile Asp Lys Asp 
            340                 345                 350         


Gln Lys Pro Gln Trp Gln Pro Thr Lys Leu Ala Asp Val Thr Glu Glu 
        355                 360                 365             


His Val Gln Trp Phe Phe Arg Lys Leu Pro Asp Thr Glu Glu Leu Lys 
    370                 375                 380                 


Leu 
385 


<210>  358
<211>  588
<212>  PRT
<213>  Aspergillus fumigatus 

<400>  358

Met Phe Lys Pro Pro Leu Cys Ser Glu Phe Arg Cys Arg Thr Ala Arg 
1               5                   10                  15      


Asn Arg Gly Ile Gly Asp Val Leu Gly Ser Lys Thr Val His Leu Val 
            20                  25                  30          


Gln Leu Pro Ala Glu Glu Asn Gln Thr Ala Arg Lys Thr Pro Arg Ser 
        35                  40                  45              


Ser Val His Pro Lys Arg Arg Asn Asp Phe Leu Ser Arg Val Ile Ser 
    50                  55                  60                  


Thr Asn Phe Leu His Phe His Ser Leu Ser Leu Ser Pro Gln Arg Arg 
65                  70                  75                  80  


Thr Val Val Cys Leu Asp Val Thr Ser Thr Gln Phe Leu Pro Leu Thr 
                85                  90                  95      


Asn Ala Gly Glu Leu Asp Leu Ala Gly Phe Ile Thr Asn Ala Ser Pro 
            100                 105                 110         


Arg Gln Ser Asp Glu Ser Ser Phe Arg Gly Cys Cys Glu Gly Met Leu 
        115                 120                 125             


Tyr Ser Leu Ser Leu Phe Ala Met Ser Thr Ala Pro Glu Leu Pro Lys 
    130                 135                 140                 


Glu Leu Pro Gly Asp Glu Pro Asp Asp Val Leu Phe Ser Ser Leu Tyr 
145                 150                 155                 160 


Gly Val Arg Leu Ile Glu Leu Asn Arg Pro Lys Lys Leu Asn Ser Leu 
                165                 170                 175     


Asn Gly Ser Met Ala Arg Lys Ile Leu Pro Arg Leu Lys Glu Trp Glu 
            180                 185                 190         


Lys Ser Gln Leu Ala Asn Ile Val Met Leu Ser Gly Ala Gly Thr Lys 
        195                 200                 205             


Ala Leu Cys Ala Gly Gly Asp Val Ala Ser Leu Ala Leu Gln Asn Glu 
    210                 215                 220                 


Gln Gly Pro Glu Gly Gln Gln Lys Ser Thr Asp Phe Phe Gly Leu Glu 
225                 230                 235                 240 


Tyr Arg Leu Asp His Ile Ile Ala Thr Tyr Thr Lys Pro Phe Ile Ser 
                245                 250                 255     


Val Met Asp Gly Ile Thr Met Gly Gly Gly Val Gly Leu Ser Val His 
            260                 265                 270         


Ala Pro Phe Arg Ile Ala Thr Glu Arg Thr Val Phe Ala Met Pro Glu 
        275                 280                 285             


Thr Thr Ile Gly Phe Phe Pro Asp Val Gly Gly Ser Phe Phe Leu Pro 
    290                 295                 300                 


Arg Leu Asp Gly Glu Ile Gly Thr Tyr Leu Ala Leu Thr Ser Glu Arg 
305                 310                 315                 320 


Leu Asn Gly Val Gln Ala Leu Tyr Ala Gly Ile Ala Thr His Tyr Phe 
                325                 330                 335     


His Ser Ser Val Leu Ser Asn Leu Thr Ala Arg Leu Ala Glu Leu Val 
            340                 345                 350         


Phe Arg Asp His Ala Ser Leu Ala Glu Arg Leu Asp Leu Val Asn Lys 
        355                 360                 365             


Thr Met Ala Glu Phe Ser Val Gly Leu Pro Pro Val Glu Gln Glu Pro 
    370                 375                 380                 


Ile Gln Leu Ala Gly Ser Leu Arg Ser Ala Ile Asp Arg Cys Phe Lys 
385                 390                 395                 400 


His Asn Thr Val Glu Glu Ile Phe Arg Ala Leu Glu Gln Glu Thr Val 
                405                 410                 415     


His Lys Glu Trp Ala Gln Lys Thr Leu Glu Thr Leu Ser Ser Arg Ser 
            420                 425                 430         


Pro Thr Ser Leu Lys Val Thr Leu Arg Gln Met Arg Val Gly Lys Lys 
        435                 440                 445             


Trp Ser Ile Ser Glu Thr Phe Gln Arg Glu Tyr Gln Ile Ala Ala Gln 
    450                 455                 460                 


Phe Met Lys His Pro Asp Phe Val Glu Gly Val Lys Ala Arg Leu Met 
465                 470                 475                 480 


Ser Lys Pro Pro Arg Gln Ala Thr Trp Gln Pro Ala Thr Leu Glu Glu 
                485                 490                 495     


Val Thr Asn Asp Ala Val Asp Ala Phe Phe Lys Leu Pro Ala Asp Lys 
            500                 505                 510         


Ser Arg Leu Thr Leu Phe Asn Lys Thr Asp Tyr Lys Gln Tyr Pro His 
        515                 520                 525             


Ala Tyr Gly Leu Pro Ser Glu Ala Glu Ile Glu Lys Phe Val Arg Asp 
    530                 535                 540                 


Ser Ser Glu Ser Ala Ser Lys Thr Val Ala Asp Phe Val Glu Lys Trp 
545                 550                 555                 560 


Gly His Lys Glu Gly Val Arg Glu Lys Val Ala Glu Val Leu Ala Arg 
                565                 570                 575     


Arg Thr Val Gln Thr Pro Glu Gly Leu Arg Trp Glu 
            580                 585             


<210>  359
<211>  481
<212>  PRT
<213>  Aspergillus nidulans

<400>  359

Met Pro Leu Arg Ala Lys Val Thr Asn Pro Gly Phe Ala Ala Thr Ser 
1               5                   10                  15      


Asn Met Ser Thr Ala Ser Asn Pro Asp Ile Pro Lys Ala Gln His Gly 
            20                  25                  30          


Asp Glu Pro Asp Asp Val Leu Phe Asn Ser Leu Phe Gly Val Arg Leu 
        35                  40                  45              


Val Glu Leu Asn Arg Pro Lys Lys Leu Asn Ser Leu Asn Gly Ser Met 
    50                  55                  60                  


Val Arg Lys Ile Leu Pro Arg Leu Lys Glu Trp Glu Lys Ser Gln Leu 
65                  70                  75                  80  


Ala Asn Ile Ile Met Val Ala Gly Ala Gly Thr Lys Ala Leu Cys Ala 
                85                  90                  95      


Gly Gly Asp Val Ala Ala Leu Ala Leu Gln Asn Glu Lys Gly Pro Glu 
            100                 105                 110         


Gly Gln Gln Ala Ser Thr Asp Phe Phe Gly Leu Glu Tyr Lys Leu Asp 
        115                 120                 125             


His Val Ile Ala Thr Tyr Ser Lys Pro Phe Ile Ser Val Met Asp Gly 
    130                 135                 140                 


Ile Thr Met Gly Gly Gly Val Gly Leu Ser Val His Ala Pro Phe Arg 
145                 150                 155                 160 


Ile Ala Thr Glu Arg Thr Val Phe Ala Met Pro Glu Thr Thr Ile Gly 
                165                 170                 175     


Phe Phe Pro Asp Val Gly Gly Ser Phe Phe Leu Pro Arg Leu Asp Gly 
            180                 185                 190         


Glu Ile Gly Thr Tyr Leu Ala Leu Thr Ser Ala Arg Leu Thr Gly Val 
        195                 200                 205             


Gln Ala Leu Tyr Ala Gly Ile Ala Thr His Tyr Phe Asp Ser Ser Val 
    210                 215                 220                 


Leu Gly Asn Leu Thr Gln Arg Leu Ser Glu Leu Val Phe Arg Asp Ser 
225                 230                 235                 240 


Ala Thr Leu Gln Glu Arg Leu Asp Leu Ile Asn Arg Thr Met Ala Glu 
                245                 250                 255     


Phe Ala Thr Gly Leu Pro Glu Glu Pro Gln Leu Ala Gly Gln Leu Arg 
            260                 265                 270         


Ser Ala Ile Asp Arg Cys Phe Arg His Asp Thr Val Glu Gln Ile Met 
        275                 280                 285             


Lys Ala Leu Glu Arg Glu Lys Lys Cys Lys Lys Trp Ala Gln Glu Thr 
    290                 295                 300                 


Leu Glu Thr Met Ser Gln Arg Ser Pro Thr Ser Leu Lys Val Ala Leu 
305                 310                 315                 320 


Arg Gln Met Arg Val Gly Gln Ala Trp Gly Ile Arg Glu Thr Phe Gln 
                325                 330                 335     


Arg Glu Tyr Glu Ile Ala Ala Arg Phe Met Gln His Pro Asp Phe Val 
            340                 345                 350         


Glu Gly Val Lys Ala Arg Leu Met Ser Lys Pro Pro Arg Gln Ala Ser 
        355                 360                 365             


Trp Gln Pro Ala Thr Leu Ala Glu Val Ser Glu Lys Asp Val Asp Glu 
    370                 375                 380                 


Phe Phe Lys Ile Pro Gln Gly Lys Glu Arg Ile Gln Leu Leu Ser Gln 
385                 390                 395                 400 


Glu Asn Trp Arg Ser Tyr Pro His Ser Tyr Gly Leu Pro Ser Glu Lys 
                405                 410                 415     


Ala Ile Glu Lys Phe Ile Arg Glu Ala Asp Pro Lys Ser Arg Ala Ser 
            420                 425                 430         


Lys Gly Glu Val Ile Glu His Phe Val Lys Glu Phe Glu His Lys Glu 
        435                 440                 445             


Gly Val Lys Glu Lys Val Ala Glu Val Leu Ala Arg Lys Thr Thr Lys 
    450                 455                 460                 


Ser Ala Glu Gly Leu Ile Trp Gln Gly Glu Gly Ala Glu Thr Asp Gly 
465                 470                 475                 480 


Gln 
    


<210>  360
<211>  1071
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 353

<400>  360
atggacagcg tcttgtttcg ccagacaggt acggtggctt ggctcgggct caaccggccg     60

aagcagttga acgcgctcag tctcgagatg atccgccttc ttcgtcgcca tttggacgag    120

atggcacaag atccatccgt ggaactcgtg gtgctgtacg gcgaaggcga ccgcgccttc    180

tgcgccggcg gcgacattcg ggcgctgtac gacgcgaagg atgagccaaa cctcgagacc    240

gcggccgcgt ttttctcaga ggagtacgcg ctcgacgatc gcgtcgcgcg gtttccaaag    300

cctgttgtcg ccttgtggga cggcatcgtg atggggggcg gggtcgggct cacctatggc    360

gcgacgtgga aggtcgcgac ggatcgcacg cggttcgcga tgcccgagac cgggattggc    420

ttctttccgg acgtcggcat gtgtcatgcg ctcagccgaa tgcagggcgg gctcggacac    480

tatctggcgc tcaccggcga gtccgttggc gccgatgtgc tcctcgcggc ggggctggcc    540

aacggctggc ttccgagcgg cgagcggccg tcgttcgagg cggaacttgt gaagcggggc    600

gaacagggag aaaccgcgga acaacttcag aggtggttgg ctgcaaggct ggccgtagag    660

caccggccat cggaggcggt cgcggacttt ctccggcggg tgcaggcgta tttcgacagc    720

ccgtcgctct ccgacatctt ggcgcgcttg cgggagggat cctcgcgcga tccgtttgcc    780

gcacaggcgc tcgagatcct gcgccagcgc tcgccgctct cgttggcggt gaccttcgag    840

gcgctccgcc gcgcagggaa cgcgacgtac cgcgaggtcc tagagaccga tctcaccctc    900

gccctccagt tcatccgccg gggcgacttt gtcgaagggg tgcgcgccca gctcgtcgac    960

aaggaccggc gccccaggtg gcgccacgcc gatctggcga gcgtgacggc cgaagaagtg   1020

gaggcatttt ttgaacccat tgcccatctt tccattccgt ttgccgattg a            1071


<210>  361
<211>  1071
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 353

<400>  361
atggacagcg tcttgtttcg ccagacaggt acggtggctt ggctcgggct caaccggccg     60

aagcagttga acgcgctcag tctcgagatg atccgccttc ttcgtcgcca tttggacgag    120

atggcacaag atccatccgt ggaactcgtg gtgctgtacg gcgaaggcga ccgcgccttc    180

tgcgccggcg gcgacattcg ggcgctgtac gacgcgaagg atgagccaaa cctcgagacc    240

gcggccgcgt ttttctcaga ggagtacgcg ctcgacgatc gcgtcgcgcg gtttccaaag    300

cctgttgtcg ccttgtggga cggcatcgtg atggggggcg gggtcgggct cacctatggc    360

gcgacgtgga aggtcgcgac ggatcgcacg cggttcgcga tgcccgagac cgggattggc    420

ttctttccgg acgtcggcat gtgtcatgcg ctcagccgaa tgcagggcgg gctcggacac    480

tatctggcgc tcaccggcga gtccgttggc gccgatgtgc tcctcgcggc ggggctggcc    540

aacggctggc ttccgagcgg cgagcggccg tcgttcgagg cggaacttgt gaagcggggc    600

gaacagggag aaaccgcgga acaacttcag aggtggttgg ctgcaaggct ggccgtagag    660

caccggccat cggaggcggt cgcggacttt ctccggcggg tgcaggcgta tttcgacagc    720

ccgtcgctct ccgacatctt ggcgcgcttg cgggagggat cctcgcgcga tccgtttgcc    780

gcacaggcgc tcgagatcct gcgccagcgc tcgccgctct cgttggcggt gaccttcgag    840

gcgctccgcc gcgcagggaa cgcgacgtac cgcgaggtcc tagagaccga tctcaccctc    900

gccctccagt tcatccgccg gggcgacttt gtcgaagggg tgcgcgccca gctcgtcgac    960

aaggaccggc gccccaggtg gcgccacgcc gatctggcga gcgtgacggc cgaagaagtg   1020

gaggcatttt ttgaacccat tgcccatctt tccattccgt ttgccgattg a            1071


<210>  362
<211>  1071
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 353

<400>  362
atggacagcg tcttgtttcg ccagacaggt acggtggctt ggctcgggct caaccggccg     60

aagcagttga acgcgctcag tctcgagatg atccgccttc ttcgtcgcca tttggacgag    120

atggcacaag atccatccgt ggaactcgtg gtgctgtacg gcgaaggcga ccgcgccttc    180

tgcgccggcg gcgacattcg ggcgctgtac gacgcgaagg atgagccaaa cctcgagacc    240

gcggccgcgt ttttctcaga ggagtacgcg ctcgacgatc gcgtcgcgcg gtttccaaag    300

cctgttgtcg ccttgtggga cggcatcgtg atggggggcg gggtcgggct cacctatggc    360

gcgacgtgga aggtcgcgac ggatcgcacg cggttcgcga tgcccgagac cgggattggc    420

ttctttccgg acgtcggcat gtgtcatgcg ctcagccgaa tgcagggcgg gctcggacac    480

tatctggcgc tcaccggcga gtccgttggc gccgatgtgc tcctcgcggc ggggctggcc    540

aacggctggc ttccgagcgg cgagcggccg tcgttcgagg cggaacttgt gaagcggggc    600

gaacagggag aaaccgcgga acaacttcag aggtggttgg ctgcaaggct ggccgtagag    660

caccggccat cggaggcggt cgcggacttt ctccggcggg tgcaggcgta tttcgacagc    720

ccgtcgctct ccgacatctt ggcgcgcttg cgggagggat cctcgcgcga tccgtttgcc    780

gcacaggcgc tcgagatcct gcgccagcgc tcgccgctct cgttggcggt gaccttcgag    840

gcgctccgcc gcgcagggaa cgcgacgtac cgcgaggtcc tagagaccga tctcaccctc    900

gccctccagt tcatccgccg gggcgacttt gtcgaagggg tgcgcgccca gctcgtcgac    960

aaggaccggc gccccaggtg gcgccacgcc gatctggcga gcgtgacggc cgaagaagtg   1020

gaggcatttt ttgaacccat tgcccatctt tccattccgt ttgccgattg a            1071


<210>  363
<211>  1071
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 353

<400>  363
atggacagcg tcttgtttcg ccagacaggt acggtggctt ggctcgggct caaccggccg     60

aagcagttga acgcgctcag tctcgagatg atccgccttc ttcgtcgcca tttggacgag    120

atggcacaag atccatccgt ggaactcgtg gtgctgtacg gcgaaggcga ccgcgccttc    180

tgcgccggcg gcgacattcg ggcgctgtac gacgcgaagg atgagccaaa cctcgagacc    240

gcggccgcgt ttttctcaga ggagtacgcg ctcgacgatc gcgtcgcgcg gtttccaaag    300

cctgttgtcg ccttgtggga cggcatcgtg atggggggcg gggtcgggct cacctatggc    360

gcgacgtgga aggtcgcgac ggatcgcacg cggttcgcga tgcccgagac cgggattggc    420

ttctttccgg acgtcggcat gtgtcatgcg ctcagccgaa tgcagggcgg gctcggacac    480

tatctggcgc tcaccggcga gtccgttggc gccgatgtgc tcctcgcggc ggggctggcc    540

aacggctggc ttccgagcgg cgagcggccg tcgttcgagg cggaacttgt gaagcggggc    600

gaacagggag aaaccgcgga acaacttcag aggtggttgg ctgcaaggct ggccgtagag    660

caccggccat cggaggcggt cgcggacttt ctccggcggg tgcaggcgta tttcgacagc    720

ccgtcgctct ccgacatctt ggcgcgcttg cgggagggat cctcgcgcga tccgtttgcc    780

gcacaggcgc tcgagatcct gcgccagcgc tcgccgctct cgttggcggt gaccttcgag    840

gcgctccgcc gcgcagggaa cgcgacgtac cgcgaggtcc tagagaccga tctcaccctc    900

gccctccagt tcatccgccg gggcgacttt gtcgaagggg tgcgcgccca gctcgtcgac    960

aaggaccggc gccccaggtg gcgccacgcc gatctggcga gcgtgacggc cgaagaagtg   1020

gaggcatttt ttgaacccat tgcccatctt tccattccgt ttgccgattg a            1071


<210>  364
<211>  1071
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 353

<400>  364
atggacagcg tcttgtttcg ccagacaggt acggtggctt ggctcgggct caaccggccg     60

aagcagttga acgcgctcag tctcgagatg atccgccttc ttcgtcgcca tttggacgag    120

atggcacaag atccatccgt ggaactcgtg gtgctgtacg gcgaaggcga ccgcgccttc    180

tgcgccggcg gcgacattcg ggcgctgtac gacgcgaagg atgagccaaa cctcgagacc    240

gcggccgcgt ttttctcaga ggagtacgcg ctcgacgatc gcgtcgcgcg gtttccaaag    300

cctgttgtcg ccttgtggga cggcatcgtg atggggggcg gggtcgggct cacctatggc    360

gcgacgtgga aggtcgcgac ggatcgcacg cggttcgcga tgcccgagac cgggattggc    420

ttctttccgg acgtcggcat gtgtcatgcg ctcagccgaa tgcagggcgg gctcggacac    480

tatctggcgc tcaccggcga gtccgttggc gccgatgtgc tcctcgcggc ggggctggcc    540

aacggctggc ttccgagcgg cgagcggccg tcgttcgagg cggaacttgt gaagcggggc    600

gaacagggag aaaccgcgga acaacttcag aggtggttgg ctgcaaggct ggccgtagag    660

caccggccat cggaggcggt cgcggacttt ctccggcggg tgcaggcgta tttcgacagc    720

ccgtcgctct ccgacatctt ggcgcgcttg cgggagggat cctcgcgcga tccgtttgcc    780

gcacaggcgc tcgagatcct gcgccagcgc tcgccgctct cgttggcggt gaccttcgag    840

gcgctccgcc gcgcagggaa cgcgacgtac cgcgaggtcc tagagaccga tctcaccctc    900

gccctccagt tcatccgccg gggcgacttt gtcgaagggg tgcgcgccca gctcgtcgac    960

aaggaccggc gccccaggtg gcgccacgcc gatctggcga gcgtgacggc cgaagaagtg   1020

gaggcatttt ttgaacccat tgcccatctt tccattccgt ttgccgattg a            1071


<210>  365
<211>  356
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:354 and encoded by SEQ ID NO:360

<400>  365

Met Asp Ser Val Leu Phe Arg Gln Thr Gly Thr Val Ala Trp Leu Gly 
1               5                   10                  15      


Leu Asn Arg Pro Lys Gln Leu Asn Ala Leu Ser Leu Glu Met Ile Arg 
            20                  25                  30          


Leu Leu Arg Arg His Leu Asp Glu Met Ala Gln Asp Pro Ser Val Glu 
        35                  40                  45              


Leu Val Val Leu Tyr Gly Glu Gly Asp Arg Ala Phe Cys Ala Gly Gly 
    50                  55                  60                  


Asp Ile Arg Ala Leu Tyr Asp Ala Lys Asp Glu Pro Asn Leu Glu Thr 
65                  70                  75                  80  


Ala Ala Ala Phe Phe Ser Glu Glu Tyr Ala Leu Asp Asp Arg Val Ala 
                85                  90                  95      


Arg Phe Pro Lys Pro Val Val Ala Leu Trp Asp Gly Ile Val Met Gly 
            100                 105                 110         


Gly Gly Val Gly Leu Thr Tyr Gly Ala Thr Trp Lys Val Ala Thr Asp 
        115                 120                 125             


Arg Thr Arg Phe Ala Met Pro Glu Thr Gly Ile Gly Phe Phe Pro Asp 
    130                 135                 140                 


Val Gly Met Cys His Ala Leu Ser Arg Met Gln Gly Gly Leu Gly His 
145                 150                 155                 160 


Tyr Leu Ala Leu Thr Gly Glu Ser Val Gly Ala Asp Val Leu Leu Ala 
                165                 170                 175     


Ala Gly Leu Ala Asn Gly Trp Leu Pro Ser Gly Glu Arg Pro Ser Phe 
            180                 185                 190         


Glu Ala Glu Leu Val Lys Arg Gly Glu Gln Gly Glu Thr Ala Glu Gln 
        195                 200                 205             


Leu Gln Arg Trp Leu Ala Ala Arg Leu Ala Val Glu His Arg Pro Ser 
    210                 215                 220                 


Glu Ala Val Ala Asp Phe Leu Arg Arg Val Gln Ala Tyr Phe Asp Ser 
225                 230                 235                 240 


Pro Ser Leu Ser Asp Ile Leu Ala Arg Leu Arg Glu Gly Ser Ser Arg 
                245                 250                 255     


Asp Pro Phe Ala Ala Gln Ala Leu Glu Ile Leu Arg Gln Arg Ser Pro 
            260                 265                 270         


Leu Ser Leu Ala Val Thr Phe Glu Ala Leu Arg Arg Ala Gly Asn Ala 
        275                 280                 285             


Thr Tyr Arg Glu Val Leu Glu Thr Asp Leu Thr Leu Ala Leu Gln Phe 
    290                 295                 300                 


Ile Arg Arg Gly Asp Phe Val Glu Gly Val Arg Ala Gln Leu Val Asp 
305                 310                 315                 320 


Lys Asp Arg Arg Pro Arg Trp Arg His Ala Asp Leu Ala Ser Val Thr 
                325                 330                 335     


Ala Glu Glu Val Glu Ala Phe Phe Glu Pro Ile Ala His Leu Ser Ile 
            340                 345                 350         


Pro Phe Ala Asp 
        355     


<210>  366
<211>  356
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:354 and encoded by SEQ ID NO:361

<400>  366

Met Asp Ser Val Leu Phe Arg Gln Thr Gly Thr Val Ala Trp Leu Gly 
1               5                   10                  15      


Leu Asn Arg Pro Lys Gln Leu Asn Ala Leu Ser Leu Glu Met Ile Arg 
            20                  25                  30          


Leu Leu Arg Arg His Leu Asp Glu Met Ala Gln Asp Pro Ser Val Glu 
        35                  40                  45              


Leu Val Val Leu Tyr Gly Glu Gly Asp Arg Ala Phe Cys Ala Gly Gly 
    50                  55                  60                  


Asp Ile Arg Ala Leu Tyr Asp Ala Lys Asp Glu Pro Asn Leu Glu Thr 
65                  70                  75                  80  


Ala Ala Ala Phe Phe Ser Glu Glu Tyr Ala Leu Asp Asp Arg Val Ala 
                85                  90                  95      


Arg Phe Pro Lys Pro Val Val Ala Leu Trp Asp Gly Ile Val Met Gly 
            100                 105                 110         


Gly Gly Val Gly Leu Thr Tyr Gly Ala Thr Trp Lys Val Ala Thr Asp 
        115                 120                 125             


Arg Thr Arg Phe Ala Met Pro Glu Thr Gly Ile Gly Phe Phe Pro Asp 
    130                 135                 140                 


Val Gly Met Cys His Ala Leu Ser Arg Met Gln Gly Gly Leu Gly His 
145                 150                 155                 160 


Tyr Leu Ala Leu Thr Gly Glu Ser Val Gly Ala Asp Val Leu Leu Ala 
                165                 170                 175     


Ala Gly Leu Ala Asn Gly Trp Leu Pro Ser Gly Glu Arg Pro Ser Phe 
            180                 185                 190         


Glu Ala Glu Leu Val Lys Arg Gly Glu Gln Gly Glu Thr Ala Glu Gln 
        195                 200                 205             


Leu Gln Arg Trp Leu Ala Ala Arg Leu Ala Val Glu His Arg Pro Ser 
    210                 215                 220                 


Glu Ala Val Ala Asp Phe Leu Arg Arg Val Gln Ala Tyr Phe Asp Ser 
225                 230                 235                 240 


Pro Ser Leu Ser Asp Ile Leu Ala Arg Leu Arg Glu Gly Ser Ser Arg 
                245                 250                 255     


Asp Pro Phe Ala Ala Gln Ala Leu Glu Ile Leu Arg Gln Arg Ser Pro 
            260                 265                 270         


Leu Ser Leu Ala Val Thr Phe Glu Ala Leu Arg Arg Ala Gly Asn Ala 
        275                 280                 285             


Thr Tyr Arg Glu Val Leu Glu Thr Asp Leu Thr Leu Ala Leu Gln Phe 
    290                 295                 300                 


Ile Arg Arg Gly Asp Phe Val Glu Gly Val Arg Ala Gln Leu Val Asp 
305                 310                 315                 320 


Lys Asp Arg Arg Pro Arg Trp Arg His Ala Asp Leu Ala Ser Val Thr 
                325                 330                 335     


Ala Glu Glu Val Glu Ala Phe Phe Glu Pro Ile Ala His Leu Ser Ile 
            340                 345                 350         


Pro Phe Ala Asp 
        355     


<210>  367
<211>  356
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:354 and encoded by SEQ ID NO:362

<400>  367

Met Asp Ser Val Leu Phe Arg Gln Thr Gly Thr Val Ala Trp Leu Gly 
1               5                   10                  15      


Leu Asn Arg Pro Lys Gln Leu Asn Ala Leu Ser Leu Glu Met Ile Arg 
            20                  25                  30          


Leu Leu Arg Arg His Leu Asp Glu Met Ala Gln Asp Pro Ser Val Glu 
        35                  40                  45              


Leu Val Val Leu Tyr Gly Glu Gly Asp Arg Ala Phe Cys Ala Gly Gly 
    50                  55                  60                  


Asp Ile Arg Ala Leu Tyr Asp Ala Lys Asp Glu Pro Asn Leu Glu Thr 
65                  70                  75                  80  


Ala Ala Ala Phe Phe Ser Glu Glu Tyr Ala Leu Asp Asp Arg Val Ala 
                85                  90                  95      


Arg Phe Pro Lys Pro Val Val Ala Leu Trp Asp Gly Ile Val Met Gly 
            100                 105                 110         


Gly Gly Val Gly Leu Thr Tyr Gly Ala Thr Trp Lys Val Ala Thr Asp 
        115                 120                 125             


Arg Thr Arg Phe Ala Met Pro Glu Thr Gly Ile Gly Phe Phe Pro Asp 
    130                 135                 140                 


Val Gly Met Cys His Ala Leu Ser Arg Met Gln Gly Gly Leu Gly His 
145                 150                 155                 160 


Tyr Leu Ala Leu Thr Gly Glu Ser Val Gly Ala Asp Val Leu Leu Ala 
                165                 170                 175     


Ala Gly Leu Ala Asn Gly Trp Leu Pro Ser Gly Glu Arg Pro Ser Phe 
            180                 185                 190         


Glu Ala Glu Leu Val Lys Arg Gly Glu Gln Gly Glu Thr Ala Glu Gln 
        195                 200                 205             


Leu Gln Arg Trp Leu Ala Ala Arg Leu Ala Val Glu His Arg Pro Ser 
    210                 215                 220                 


Glu Ala Val Ala Asp Phe Leu Arg Arg Val Gln Ala Tyr Phe Asp Ser 
225                 230                 235                 240 


Pro Ser Leu Ser Asp Ile Leu Ala Arg Leu Arg Glu Gly Ser Ser Arg 
                245                 250                 255     


Asp Pro Phe Ala Ala Gln Ala Leu Glu Ile Leu Arg Gln Arg Ser Pro 
            260                 265                 270         


Leu Ser Leu Ala Val Thr Phe Glu Ala Leu Arg Arg Ala Gly Asn Ala 
        275                 280                 285             


Thr Tyr Arg Glu Val Leu Glu Thr Asp Leu Thr Leu Ala Leu Gln Phe 
    290                 295                 300                 


Ile Arg Arg Gly Asp Phe Val Glu Gly Val Arg Ala Gln Leu Val Asp 
305                 310                 315                 320 


Lys Asp Arg Arg Pro Arg Trp Arg His Ala Asp Leu Ala Ser Val Thr 
                325                 330                 335     


Ala Glu Glu Val Glu Ala Phe Phe Glu Pro Ile Ala His Leu Ser Ile 
            340                 345                 350         


Pro Phe Ala Asp 
        355     


<210>  368
<211>  356
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:354 and encoded by SEQ ID NO:363

<400>  368

Met Asp Ser Val Leu Phe Arg Gln Thr Gly Thr Val Ala Trp Leu Gly 
1               5                   10                  15      


Leu Asn Arg Pro Lys Gln Leu Asn Ala Leu Ser Leu Glu Met Ile Arg 
            20                  25                  30          


Leu Leu Arg Arg His Leu Asp Glu Met Ala Gln Asp Pro Ser Val Glu 
        35                  40                  45              


Leu Val Val Leu Tyr Gly Glu Gly Asp Arg Ala Phe Cys Ala Gly Gly 
    50                  55                  60                  


Asp Ile Arg Ala Leu Tyr Asp Ala Lys Asp Glu Pro Asn Leu Glu Thr 
65                  70                  75                  80  


Ala Ala Ala Phe Phe Ser Glu Glu Tyr Ala Leu Asp Asp Arg Val Ala 
                85                  90                  95      


Arg Phe Pro Lys Pro Val Val Ala Leu Trp Asp Gly Ile Val Met Gly 
            100                 105                 110         


Gly Gly Val Gly Leu Thr Tyr Gly Ala Thr Trp Lys Val Ala Thr Asp 
        115                 120                 125             


Arg Thr Arg Phe Ala Met Pro Glu Thr Gly Ile Gly Phe Phe Pro Asp 
    130                 135                 140                 


Val Gly Met Cys His Ala Leu Ser Arg Met Gln Gly Gly Leu Gly His 
145                 150                 155                 160 


Tyr Leu Ala Leu Thr Gly Glu Ser Val Gly Ala Asp Val Leu Leu Ala 
                165                 170                 175     


Ala Gly Leu Ala Asn Gly Trp Leu Pro Ser Gly Glu Arg Pro Ser Phe 
            180                 185                 190         


Glu Ala Glu Leu Val Lys Arg Gly Glu Gln Gly Glu Thr Ala Glu Gln 
        195                 200                 205             


Leu Gln Arg Trp Leu Ala Ala Arg Leu Ala Val Glu His Arg Pro Ser 
    210                 215                 220                 


Glu Ala Val Ala Asp Phe Leu Arg Arg Val Gln Ala Tyr Phe Asp Ser 
225                 230                 235                 240 


Pro Ser Leu Ser Asp Ile Leu Ala Arg Leu Arg Glu Gly Ser Ser Arg 
                245                 250                 255     


Asp Pro Phe Ala Ala Gln Ala Leu Glu Ile Leu Arg Gln Arg Ser Pro 
            260                 265                 270         


Leu Ser Leu Ala Val Thr Phe Glu Ala Leu Arg Arg Ala Gly Asn Ala 
        275                 280                 285             


Thr Tyr Arg Glu Val Leu Glu Thr Asp Leu Thr Leu Ala Leu Gln Phe 
    290                 295                 300                 


Ile Arg Arg Gly Asp Phe Val Glu Gly Val Arg Ala Gln Leu Val Asp 
305                 310                 315                 320 


Lys Asp Arg Arg Pro Arg Trp Arg His Ala Asp Leu Ala Ser Val Thr 
                325                 330                 335     


Ala Glu Glu Val Glu Ala Phe Phe Glu Pro Ile Ala His Leu Ser Ile 
            340                 345                 350         


Pro Phe Ala Asp 
        355     


<210>  369
<211>  356
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:354 and encoded by SEQ ID NO:364

<400>  369

Met Asp Ser Val Leu Phe Arg Gln Thr Gly Thr Val Ala Trp Leu Gly 
1               5                   10                  15      


Leu Asn Arg Pro Lys Gln Leu Asn Ala Leu Ser Leu Glu Met Ile Arg 
            20                  25                  30          


Leu Leu Arg Arg His Leu Asp Glu Met Ala Gln Asp Pro Ser Val Glu 
        35                  40                  45              


Leu Val Val Leu Tyr Gly Glu Gly Asp Arg Ala Phe Cys Ala Gly Gly 
    50                  55                  60                  


Asp Ile Arg Ala Leu Tyr Asp Ala Lys Asp Glu Pro Asn Leu Glu Thr 
65                  70                  75                  80  


Ala Ala Ala Phe Phe Ser Glu Glu Tyr Ala Leu Asp Asp Arg Val Ala 
                85                  90                  95      


Arg Phe Pro Lys Pro Val Val Ala Leu Trp Asp Gly Ile Val Met Gly 
            100                 105                 110         


Gly Gly Val Gly Leu Thr Tyr Gly Ala Thr Trp Lys Val Ala Thr Asp 
        115                 120                 125             


Arg Thr Arg Phe Ala Met Pro Glu Thr Gly Ile Gly Phe Phe Pro Asp 
    130                 135                 140                 


Val Gly Met Cys His Ala Leu Ser Arg Met Gln Gly Gly Leu Gly His 
145                 150                 155                 160 


Tyr Leu Ala Leu Thr Gly Glu Ser Val Gly Ala Asp Val Leu Leu Ala 
                165                 170                 175     


Ala Gly Leu Ala Asn Gly Trp Leu Pro Ser Gly Glu Arg Pro Ser Phe 
            180                 185                 190         


Glu Ala Glu Leu Val Lys Arg Gly Glu Gln Gly Glu Thr Ala Glu Gln 
        195                 200                 205             


Leu Gln Arg Trp Leu Ala Ala Arg Leu Ala Val Glu His Arg Pro Ser 
    210                 215                 220                 


Glu Ala Val Ala Asp Phe Leu Arg Arg Val Gln Ala Tyr Phe Asp Ser 
225                 230                 235                 240 


Pro Ser Leu Ser Asp Ile Leu Ala Arg Leu Arg Glu Gly Ser Ser Arg 
                245                 250                 255     


Asp Pro Phe Ala Ala Gln Ala Leu Glu Ile Leu Arg Gln Arg Ser Pro 
            260                 265                 270         


Leu Ser Leu Ala Val Thr Phe Glu Ala Leu Arg Arg Ala Gly Asn Ala 
        275                 280                 285             


Thr Tyr Arg Glu Val Leu Glu Thr Asp Leu Thr Leu Ala Leu Gln Phe 
    290                 295                 300                 


Ile Arg Arg Gly Asp Phe Val Glu Gly Val Arg Ala Gln Leu Val Asp 
305                 310                 315                 320 


Lys Asp Arg Arg Pro Arg Trp Arg His Ala Asp Leu Ala Ser Val Thr 
                325                 330                 335     


Ala Glu Glu Val Glu Ala Phe Phe Glu Pro Ile Ala His Leu Ser Ile 
            340                 345                 350         


Pro Phe Ala Asp 
        355     


<210>  370
<211>  2274
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  370
ttgtcgtatc gcgatctcgt ctcgcgcctc accctcgaag aaaaagcatc cctctgctcc     60

gggctcaact tctggcaaac gaagcccatc gagcgcctcg gcatcccgtc tctctgcatg    120

acggacgggc cgcacggcgt tcggctgcag cggcagggcg gatcgttcac cgattcggag    180

cccgccacgt gcttcccgac agccgccgcg ctcgcgagtt cctgggatcc cgcgctcgtg    240

gagcggattg gccaggcgct cggcgacgaa tgccgcgcgc tcggcgttca cgtgttgctc    300

gggcccggcg ccaacatcaa gcgatctccc ttgtgcgggc gcaacttcga gtacttctcg    360

gaggatccgc ttctctcgag cgaaatggcc gcggcgcata tccggggcgt ccagtcgcgc    420

ggcgtcggat cgtcgctcaa gcactttgct gccaacaacc aggagtaccg gcgcatgacg    480

acgagcgccg aggtggacga gcgcacgctg cgcgagatct atctcgcgag cttcgaaggc    540

gccgtcaagg gtggacgccc gtggacggtc atgtgcgcgt acaatcgcct caacggcacc    600

tactgctcgg aacacccgtg gcttctcacg caggtgctgc gccgggaatg gggatttgat    660

ggcgtcgtgg tgtcggactg gggggcggtg aacgatcgcg tccaaggcct cgctgcaggg    720

ctggacctcg aaatgcccgg cgggccgtac gcgcaggacg ccgagatcgt ccaggctgtg    780

cgagacggtc gcctggacga agccgtgctc gatgcggccg tggaacgcct gctcgcgctc    840

atcgaccggg cctaccggcc gcagggcgat tccgccgatc tcgacgcgca tcaccgcctt    900

gcccgccagg ccgcggccga gtcgatggtg cttctgaaga acgacggggc cgtgttgccc    960

atcgcgccag ggcggcgggt ggcggtgatt ggcgcgttcg ccgtgtcgcc gcgctaccag   1020

ggaggaggaa gctcgcacgt caatcccgcg cgcctcgacg agccgctcgc ggagatgcgc   1080

cgcgcgtttg gcgaccagct tgtcctgtac gcgccggggt acgcgctcga cgacgacgcg   1140

cctcgcctcg agctcatcga ggaggccgtg cgcgctgcgg cgcaggcgga tgtcgccgcc   1200

atctttgcag ggctgccgga gagctgggag tctgaaggat atgatcgccc gcacatgcga   1260

atgccggacg cgcacgtggc gctcatcgaa gcggtgacgt cggctcagcc ccgcacggtt   1320

gtcgtgctct cgaacggcgc gcccgtcgag atgccttgga tccaccgcgt gcctgccgtg   1380

atcgaggcgt atctcgcggg gcaggccttc ggcggcgcca tcgcggacgt gctgtcgggc   1440

gctgtgaacc cgtccggcaa gctggccgag acgtttccgc ttcggctcga gcacaaccct   1500

tcgcatccat acttccccgg cgaaggcgac agatccgaat accgagaagg tgtcttcgtc   1560

ggctatcgct actacgacac caaggagatg gacgtgctgt ttcccttcgg gcacgggctg   1620

tcgtacacca cgttcgagta cgaggccatc cgcatgtctc gtgagcaggt ccgggacgac   1680

gacgtgctca ccgtgcaggt ggacgtgcgc aataccgggc agcgcgcggg caaagaggtg   1740

gtccaggtct atgtcgagcc gaggtcctcg cgagtcgttc gacctcggcg cgagcttcgc   1800

gccttcgcca aggtggcgct ggcacccggc gagacgcgta cggtcgaatt tcagctgggc   1860

aagcgcgcgt ttgcctacta cgacgtcgat gctggcgatt tcgccgtgga gagcggctgg   1920

tacgagatcc gcgtcggatc gtcctcgcgt gatctgcgcc tcaccgcctc cgtggaggtg   1980

acatccgccg ccccgcgcag gccggtgtcg gtccacgcca atgcagcgct gggcgatctg   2040

ctggacgatc cggccaccgg tccggtgctc cgcgagctct tgaaggagaa gctcgccgat   2100

tcgccgcttg gcagcgagat ggacgccaat ccgatgttcg aggcgttcat gcggttcacg   2160

cccatcggtc gtgtcacgac gctgtttggg gtgccgcggg acgagaacga gcgagttctt   2220

gcgaagctgc gagccgcgca ggaagagggc caaccggagg aagggcgggg gtga         2274


<210>  371
<211>  757
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  371

Met Ser Tyr Arg Asp Leu Val Ser Arg Leu Thr Leu Glu Glu Lys Ala 
1               5                   10                  15      


Ser Leu Cys Ser Gly Leu Asn Phe Trp Gln Thr Lys Pro Ile Glu Arg 
            20                  25                  30          


Leu Gly Ile Pro Ser Leu Cys Met Thr Asp Gly Pro His Gly Val Arg 
        35                  40                  45              


Leu Gln Arg Gln Gly Gly Ser Phe Thr Asp Ser Glu Pro Ala Thr Cys 
    50                  55                  60                  


Phe Pro Thr Ala Ala Ala Leu Ala Ser Ser Trp Asp Pro Ala Leu Val 
65                  70                  75                  80  


Glu Arg Ile Gly Gln Ala Leu Gly Asp Glu Cys Arg Ala Leu Gly Val 
                85                  90                  95      


His Val Leu Leu Gly Pro Gly Ala Asn Ile Lys Arg Ser Pro Leu Cys 
            100                 105                 110         


Gly Arg Asn Phe Glu Tyr Phe Ser Glu Asp Pro Leu Leu Ser Ser Glu 
        115                 120                 125             


Met Ala Ala Ala His Ile Arg Gly Val Gln Ser Arg Gly Val Gly Ser 
    130                 135                 140                 


Ser Leu Lys His Phe Ala Ala Asn Asn Gln Glu Tyr Arg Arg Met Thr 
145                 150                 155                 160 


Thr Ser Ala Glu Val Asp Glu Arg Thr Leu Arg Glu Ile Tyr Leu Ala 
                165                 170                 175     


Ser Phe Glu Gly Ala Val Lys Gly Gly Arg Pro Trp Thr Val Met Cys 
            180                 185                 190         


Ala Tyr Asn Arg Leu Asn Gly Thr Tyr Cys Ser Glu His Pro Trp Leu 
        195                 200                 205             


Leu Thr Gln Val Leu Arg Arg Glu Trp Gly Phe Asp Gly Val Val Val 
    210                 215                 220                 


Ser Asp Trp Gly Ala Val Asn Asp Arg Val Gln Gly Leu Ala Ala Gly 
225                 230                 235                 240 


Leu Asp Leu Glu Met Pro Gly Gly Pro Tyr Ala Gln Asp Ala Glu Ile 
                245                 250                 255     


Val Gln Ala Val Arg Asp Gly Arg Leu Asp Glu Ala Val Leu Asp Ala 
            260                 265                 270         


Ala Val Glu Arg Leu Leu Ala Leu Ile Asp Arg Ala Tyr Arg Pro Gln 
        275                 280                 285             


Gly Asp Ser Ala Asp Leu Asp Ala His His Arg Leu Ala Arg Gln Ala 
    290                 295                 300                 


Ala Ala Glu Ser Met Val Leu Leu Lys Asn Asp Gly Ala Val Leu Pro 
305                 310                 315                 320 


Ile Ala Pro Gly Arg Arg Val Ala Val Ile Gly Ala Phe Ala Val Ser 
                325                 330                 335     


Pro Arg Tyr Gln Gly Gly Gly Ser Ser His Val Asn Pro Ala Arg Leu 
            340                 345                 350         


Asp Glu Pro Leu Ala Glu Met Arg Arg Ala Phe Gly Asp Gln Leu Val 
        355                 360                 365             


Leu Tyr Ala Pro Gly Tyr Ala Leu Asp Asp Asp Ala Pro Arg Leu Glu 
    370                 375                 380                 


Leu Ile Glu Glu Ala Val Arg Ala Ala Ala Gln Ala Asp Val Ala Ala 
385                 390                 395                 400 


Ile Phe Ala Gly Leu Pro Glu Ser Trp Glu Ser Glu Gly Tyr Asp Arg 
                405                 410                 415     


Pro His Met Arg Met Pro Asp Ala His Val Ala Leu Ile Glu Ala Val 
            420                 425                 430         


Thr Ser Ala Gln Pro Arg Thr Val Val Val Leu Ser Asn Gly Ala Pro 
        435                 440                 445             


Val Glu Met Pro Trp Ile His Arg Val Pro Ala Val Ile Glu Ala Tyr 
    450                 455                 460                 


Leu Ala Gly Gln Ala Phe Gly Gly Ala Ile Ala Asp Val Leu Ser Gly 
465                 470                 475                 480 


Ala Val Asn Pro Ser Gly Lys Leu Ala Glu Thr Phe Pro Leu Arg Leu 
                485                 490                 495     


Glu His Asn Pro Ser His Pro Tyr Phe Pro Gly Glu Gly Asp Arg Ser 
            500                 505                 510         


Glu Tyr Arg Glu Gly Val Phe Val Gly Tyr Arg Tyr Tyr Asp Thr Lys 
        515                 520                 525             


Glu Met Asp Val Leu Phe Pro Phe Gly His Gly Leu Ser Tyr Thr Thr 
    530                 535                 540                 


Phe Glu Tyr Glu Ala Ile Arg Met Ser Arg Glu Gln Val Arg Asp Asp 
545                 550                 555                 560 


Asp Val Leu Thr Val Gln Val Asp Val Arg Asn Thr Gly Gln Arg Ala 
                565                 570                 575     


Gly Lys Glu Val Val Gln Val Tyr Val Glu Pro Arg Ser Ser Arg Val 
            580                 585                 590         


Val Arg Pro Arg Arg Glu Leu Arg Ala Phe Ala Lys Val Ala Leu Ala 
        595                 600                 605             


Pro Gly Glu Thr Arg Thr Val Glu Phe Gln Leu Gly Lys Arg Ala Phe 
    610                 615                 620                 


Ala Tyr Tyr Asp Val Asp Ala Gly Asp Phe Ala Val Glu Ser Gly Trp 
625                 630                 635                 640 


Tyr Glu Ile Arg Val Gly Ser Ser Ser Arg Asp Leu Arg Leu Thr Ala 
                645                 650                 655     


Ser Val Glu Val Thr Ser Ala Ala Pro Arg Arg Pro Val Ser Val His 
            660                 665                 670         


Ala Asn Ala Ala Leu Gly Asp Leu Leu Asp Asp Pro Ala Thr Gly Pro 
        675                 680                 685             


Val Leu Arg Glu Leu Leu Lys Glu Lys Leu Ala Asp Ser Pro Leu Gly 
    690                 695                 700                 


Ser Glu Met Asp Ala Asn Pro Met Phe Glu Ala Phe Met Arg Phe Thr 
705                 710                 715                 720 


Pro Ile Gly Arg Val Thr Thr Leu Phe Gly Val Pro Arg Asp Glu Asn 
                725                 730                 735     


Glu Arg Val Leu Ala Lys Leu Arg Ala Ala Gln Glu Glu Gly Gln Pro 
            740                 745                 750         


Glu Glu Gly Arg Gly 
        755         


<210>  372
<211>  755
<212>  PRT
<213>  Clostridium thermocellum 

<400>  372

Met Ala Val Asp Ile Lys Lys Ile Ile Lys Gln Met Thr Leu Glu Glu 
1               5                   10                  15      


Lys Ala Gly Leu Cys Ser Gly Leu Asp Phe Trp His Thr Lys Pro Val 
            20                  25                  30          


Glu Arg Leu Gly Ile Pro Ser Ile Met Met Thr Asp Gly Pro His Gly 
        35                  40                  45              


Leu Arg Lys Gln Arg Glu Asp Ala Glu Ile Ala Asp Ile Asn Asn Ser 
    50                  55                  60                  


Val Pro Ala Thr Cys Phe Pro Ser Ala Ala Gly Leu Ala Cys Ser Trp 
65                  70                  75                  80  


Asp Arg Glu Leu Val Glu Arg Val Gly Ala Ala Leu Gly Glu Glu Cys 
                85                  90                  95      


Gln Ala Glu Asn Val Ser Ile Leu Leu Gly Pro Gly Ala Asn Ile Lys 
            100                 105                 110         


Arg Ser Pro Leu Cys Gly Arg Asn Phe Glu Tyr Phe Ser Glu Asp Pro 
        115                 120                 125             


Tyr Leu Ser Ser Glu Leu Ala Ala Ser His Ile Lys Gly Val Gln Ser 
    130                 135                 140                 


Gln Gly Val Gly Ala Cys Leu Lys His Phe Ala Ala Asn Asn Gln Glu 
145                 150                 155                 160 


His Arg Arg Met Thr Val Asp Thr Ile Val Asp Glu Arg Thr Leu Arg 
                165                 170                 175     


Glu Ile Tyr Phe Ala Ser Phe Glu Asn Ala Val Lys Lys Ala Arg Pro 
            180                 185                 190         


Trp Val Val Met Cys Ala Tyr Asn Lys Leu Asn Gly Glu Tyr Cys Ser 
        195                 200                 205             


Glu Asn Arg Tyr Leu Leu Thr Glu Val Leu Lys Asn Glu Trp Met His 
    210                 215                 220                 


Asp Gly Phe Val Val Ser Asp Trp Gly Ala Val Asn Asp Arg Val Ser 
225                 230                 235                 240 


Gly Leu Asp Ala Gly Leu Asp Leu Glu Met Pro Thr Ser His Gly Ile 
                245                 250                 255     


Thr Asp Lys Lys Ile Val Glu Ala Val Lys Ser Gly Lys Leu Ser Glu 
            260                 265                 270         


Asn Ile Leu Asn Arg Ala Val Glu Arg Ile Leu Lys Val Ile Phe Met 
        275                 280                 285             


Ala Leu Glu Asn Lys Lys Glu Asn Ala Gln Tyr Asp Lys Asp Ala His 
    290                 295                 300                 


His Arg Leu Ala Arg Gln Ala Ala Ala Glu Ser Met Val Leu Leu Lys 
305                 310                 315                 320 


Asn Glu Asp Asp Val Leu Pro Leu Lys Lys Ser Gly Thr Ile Ala Leu 
                325                 330                 335     


Ile Gly Ala Phe Val Lys Lys Pro Arg Tyr Gln Gly Ser Gly Ser Ser 
            340                 345                 350         


His Ile Thr Pro Thr Arg Leu Asp Asp Ile Tyr Glu Glu Ile Lys Lys 
        355                 360                 365             


Ala Gly Gly Asp Lys Val Asn Leu Val Tyr Ser Glu Gly Tyr Arg Leu 
    370                 375                 380                 


Glu Asn Asp Gly Ile Asp Glu Glu Leu Ile Asn Glu Ala Lys Lys Ala 
385                 390                 395                 400 


Ala Ser Ser Ser Asp Val Ala Val Val Phe Ala Gly Leu Pro Asp Glu 
                405                 410                 415     


Tyr Glu Ser Glu Gly Phe Asp Arg Thr His Met Ser Ile Pro Glu Asn 
            420                 425                 430         


Gln Asn Arg Leu Ile Glu Ala Val Ala Glu Val Gln Ser Asn Ile Val 
        435                 440                 445             


Val Val Leu Leu Asn Gly Ser Pro Val Glu Met Pro Trp Ile Asp Lys 
    450                 455                 460                 


Val Lys Ser Val Leu Glu Ala Tyr Leu Gly Gly Gln Ala Leu Gly Gly 
465                 470                 475                 480 


Ala Leu Ala Asp Val Leu Phe Gly Glu Val Asn Pro Ser Gly Lys Leu 
                485                 490                 495     


Ala Glu Thr Phe Pro Val Lys Leu Ser His Asn Pro Ser Tyr Leu Asn 
            500                 505                 510         


Phe Pro Gly Glu Asp Asp Arg Val Glu Tyr Lys Glu Gly Leu Phe Val 
        515                 520                 525             


Gly Tyr Arg Tyr Tyr Asp Thr Lys Gly Ile Glu Pro Leu Phe Pro Phe 
    530                 535                 540                 


Gly His Gly Leu Ser Tyr Thr Lys Phe Glu Tyr Ser Asp Ile Ser Val 
545                 550                 555                 560 


Asp Lys Lys Asp Val Ser Asp Asn Ser Ile Ile Asn Val Ser Val Lys 
                565                 570                 575     


Val Lys Asn Val Gly Lys Met Ala Gly Lys Glu Ile Val Gln Leu Tyr 
            580                 585                 590         


Val Lys Asp Val Lys Ser Ser Val Arg Arg Pro Glu Lys Glu Leu Lys 
        595                 600                 605             


Gly Phe Glu Lys Val Phe Leu Asn Pro Gly Glu Glu Lys Thr Val Thr 
    610                 615                 620                 


Phe Thr Leu Asp Lys Arg Ala Phe Ala Tyr Tyr Asn Thr Gln Ile Lys 
625                 630                 635                 640 


Asp Trp His Val Glu Ser Gly Glu Phe Leu Ile Leu Ile Gly Arg Ser 
                645                 650                 655     


Ser Arg Asp Ile Val Leu Lys Glu Ser Val Arg Val Asn Ser Thr Val 
            660                 665                 670         


Lys Ile Arg Lys Arg Phe Thr Val Asn Ser Ala Val Glu Asp Val Met 
        675                 680                 685             


Ser Asp Ser Ser Ala Ala Ala Val Leu Gly Pro Val Leu Lys Glu Ile 
    690                 695                 700                 


Thr Asp Ala Leu Gln Ile Asp Met Asp Asn Ala His Asp Met Met Ala 
705                 710                 715                 720 


Ala Asn Ile Lys Asn Met Pro Leu Arg Ser Leu Val Gly Tyr Ser Gln 
                725                 730                 735     


Gly Arg Leu Ser Glu Glu Met Leu Glu Glu Leu Val Asp Lys Ile Asn 
            740                 745                 750         


Asn Val Glu 
        755 


<210>  373
<211>  741
<212>  PRT
<213>  Leuconostoc mesenteroides

<400>  373

Met Ser Thr Glu Phe Asn Leu Ser Phe Val Gln Gly Leu Thr Val Arg 
1               5                   10                  15      


Glu Lys Ala Glu Leu Val Thr Gly Lys Asp Phe Trp Phe Thr Ala Glu 
            20                  25                  30          


Asn Ile Glu Asn Asp Ile Pro Lys Ile Met Val Thr Asp Gly Pro Ser 
        35                  40                  45              


Gly Leu Arg Lys Gln Ala Ser Ser Ala Asp Ala Leu Gly Leu Asn Gln 
    50                  55                  60                  


Ser Val Glu Ala Ile Ala Phe Pro Ser Ser Ala Leu Met Ala Ser Ser 
65                  70                  75                  80  


Phe Asn Val Asp Met Leu Tyr Gln Leu Gly Gln Asn Leu Gly Thr Ala 
                85                  90                  95      


Ser Arg Ala Glu Asn Val Ser Val Leu Leu Gly Pro Gly Ile Asn Ile 
            100                 105                 110         


Lys Arg Ser Pro Leu Ala Gly Arg Asn Phe Glu Tyr Phe Ser Glu Asp 
        115                 120                 125             


Pro Tyr Leu Thr Gly Glu Leu Gly Ser Ala Tyr Val Lys Gly Val Gln 
    130                 135                 140                 


Ser Gln Gly Val Gly Val Ser Val Lys His Phe Ala Ala Asn Asn Arg 
145                 150                 155                 160 


Glu Asp Gln Arg Phe Thr Ser Ser Ser Asn Val Asp Glu Arg Ala Leu 
                165                 170                 175     


Arg Glu Ile Tyr Leu Leu Ala Phe Glu Lys Ile Val Lys Glu Ala His 
            180                 185                 190         


Pro Ala Thr Leu Met Cys Ser Tyr Asn Ala Ile Asn Gly Val Leu Asn 
        195                 200                 205             


Ser Gln Asn Tyr Arg Leu Leu Thr Glu Ile Leu Arg Asn Glu Trp Gly 
    210                 215                 220                 


Tyr Thr Gly Val Val Met Ser Asp Trp Gly Ala Val Ala Asp Asn Ile 
225                 230                 235                 240 


Ala Ser Leu Lys Ala Gly Leu Asp Leu Glu Met Pro Gly Asn Gly Ala 
                245                 250                 255     


Tyr Ser Ile Asp Arg Ile Val Ser Ala Val Gln Asn Gly Gln Leu Glu 
            260                 265                 270         


Glu Ser Lys Leu Asp Ile Ser Val Leu Arg Val Leu Ala Leu Val Glu 
        275                 280                 285             


Lys Phe Arg Val Ser Glu Asp Asp Ser Thr Asp Tyr Asp Lys Asn Asn 
    290                 295                 300                 


Gln His Glu Phe Ala Arg Lys Ala Ala Glu Asp Ser Ile Ala Leu Leu 
305                 310                 315                 320 


Lys Asn Asp Asp Asp Val Leu Pro Ile Lys Gln Thr Glu Lys Ile Ala 
                325                 330                 335     


Leu Ile Gly Glu Leu Ala Gln Asn Pro Arg Tyr Gln Gly Gly Gly Ser 
            340                 345                 350         


Ser His Val Asn Ala Tyr Lys Val Val Thr Pro His Glu Val Ala Ser 
        355                 360                 365             


Asn Ser Asp Tyr Asn Val Thr Tyr Thr Ala Gly Tyr Ser Leu Ser Glu 
    370                 375                 380                 


Glu Lys Gly Asn Leu Asp Leu Glu Gln Gln Ala Glu Ser Ile Ala Glu 
385                 390                 395                 400 


Leu Ser Asp Lys Ile Ile Phe Phe Ala Gly Val Pro Glu Gln Asp Glu 
                405                 410                 415     


Ser Glu Gly Phe Asp Lys Lys Thr Ile Asp Leu Pro Glu Asn Gln Val 
            420                 425                 430         


Asn Leu Ile Gln Lys Leu Ser Ala Ile Asn Pro Asn Ile Ile Val Val 
        435                 440                 445             


Leu Gln Asn Gly Ser Ala Val Ala Thr Pro Trp Arg Asn Lys Val Lys 
    450                 455                 460                 


Ala Ile Val Glu Thr Tyr Leu Ala Gly Glu Ala Val Gly Glu Ala Thr 
465                 470                 475                 480 


Trp Asn Ile Leu Thr Gly Gln Thr Asn Pro Ser Gly Lys Leu Ala Glu 
                485                 490                 495     


Thr Phe Pro Glu Lys Ile Glu Asp Thr Pro Ala Tyr Gly Thr Phe Asn 
            500                 505                 510         


Ala Ser Val Asp Glu Glu Asn Tyr His Glu Gly Ile Phe Val Gly Tyr 
        515                 520                 525             


Arg His Tyr Asp Leu Lys Arg Lys Glu Val Ala Phe Pro Phe Gly His 
    530                 535                 540                 


Gly Leu Ser Tyr Thr Asp Phe Lys Tyr Asp Asp Leu Glu Ile Val Ala 
545                 550                 555                 560 


Asn Thr Lys Lys His Val Thr Gly Lys Ile Lys Ile Thr Asn Val Gly 
                565                 570                 575     


Ser Ile Tyr Gly Lys Glu Thr Ala Gln Ile Tyr Ile Gln Asn Leu Glu 
            580                 585                 590         


Ser Arg Val Glu Lys Pro Arg Gln Glu Leu Lys Ala Phe Val Lys Val 
        595                 600                 605             


Gly Leu Asn Pro Gly Glu Ser Lys Thr Val Glu Phe Phe Leu Asp Arg 
    610                 615                 620                 


Arg Ser Phe Ala Trp Tyr Asn Val Lys Lys Ser Ile Trp Gln Val Asp 
625                 630                 635                 640 


Gln Gly Asp Tyr Asn Leu Lys Ile Gly Ser Ser Ser Arg Asp Ile Arg 
                645                 650                 655     


Leu Glu Lys Thr Val Ser Leu Glu Met Gly Thr Thr Asn Asn Arg Pro 
            660                 665                 670         


Ile Ser Gly Asp Thr Tyr Ile Ser Glu Ile Ile Asn Arg Asp Gly Leu 
        675                 680                 685             


His Glu Ser Leu Val Ala Ser Gly Leu Gln Thr Ala Ile Glu Ser Ile 
    690                 695                 700                 


Ser Ala Ser Asp Ser Asn Arg Glu Leu Met Glu Asn Leu Pro Leu Arg 
705                 710                 715                 720 


Ala Ile Ile Met Ile Gly Ala Asn Val Asp Gln Val Asn Lys Phe Ile 
                725                 730                 735     


Glu Leu Ala Asn Asn 
            740     


<210>  374
<211>  795
<212>  PRT
<213>  Lactobacillus casei 

<400>  374

Met Gly Val Val Val Ser Asn Phe His Leu Ala Lys Ile Thr Ala Glu 
1               5                   10                  15      


Glu Lys Val Lys Leu Thr Ser Gly Lys Asp Phe Trp Thr Ser Glu His 
            20                  25                  30          


Leu Ala Asp Lys Gly Ile Pro Ser Phe Arg Met Ser Asp Gly Pro His 
        35                  40                  45              


Gly Leu Arg Tyr Gln Ala Leu Ala Ala Asp His Leu Gly Ile Asn Asp 
    50                  55                  60                  


Ser Val Pro Ser Thr Ser Phe Pro Thr Ala Ser Ala Ser Ala Ala Ala 
65                  70                  75                  80  


Trp Asp Pro Asp Leu Ile Gln Ala Met Gly Lys Ala Ile Gly Leu Glu 
                85                  90                  95      


Ala Gln Ser Leu Gly Val Asp Met Val Leu Gly Pro Gly Val Asn Met 
            100                 105                 110         


Lys Arg Asn Pro Leu Cys Gly Arg Asn Phe Glu Tyr Phe Ser Glu Asp 
        115                 120                 125             


Pro Phe Leu Ala Gly Lys Leu Gly Ala Ala Trp Ile Asn Gly Ile Gln 
    130                 135                 140                 


Ser Gln Gly Ile Ala Ala Cys Leu Lys His Phe Ala Ala Asn Asn Gln 
145                 150                 155                 160 


Glu Asn Asp Arg Leu Ser Ser Asp Ser Leu Val Asp Pro Thr Ala Leu 
                165                 170                 175     


His Glu Ile Tyr Leu Glu Ala Phe Arg Ile Ala Val Thr Glu Ser His 
            180                 185                 190         


Pro Glu Ala Val Met Cys Ser Tyr Asn Lys Ile Asn Gly Thr Tyr Ala 
        195                 200                 205             


Ser Asp Asn Leu Tyr Leu Met Thr Gln Val Leu Arg Gln Gln Phe Gly 
    210                 215                 220                 


Phe Gly Gly Ala Val Ile Thr Asp Trp Gly Ala Leu Asn Asp Lys Val 
225                 230                 235                 240 


Ala Ala Leu Asn Ala Gly Thr Asp Leu Glu Met Pro Gly Asp Asp His 
                245                 250                 255     


Leu Phe Asp Gly Glu Ala Leu Gln Ala Tyr Gln Gln Gly Thr Leu Lys 
            260                 265                 270         


Leu Ala Ser Leu Asp Arg Ala Val Thr Lys Ile Ala Glu Ile Ala Arg 
        275                 280                 285             


Lys Gln Arg Pro Lys Phe Gln Gly Ser Arg Glu Gln Leu Leu Gln Ala 
    290                 295                 300                 


Asn Gly Gln Leu Ala Gln Lys Ile Ala Glu Ser Ala Ile Val Leu Leu 
305                 310                 315                 320 


Lys Asn Glu Ala Ala Leu Leu Pro Leu Gln Ala Thr Asp Thr Val Ala 
                325                 330                 335     


Val Ile Gly Glu Leu Ala Lys Ala Thr Arg Phe Gln Gly Ala Gly Ser 
            340                 345                 350         


Ser His Ile Asn Ala Ser Glu Ile Val Ser Val Leu Asp Gly Leu Lys 
        355                 360                 365             


Gln Lys Lys Val Ser Phe Asp Tyr Ala Ala Gly Tyr Arg Leu Asp Asp 
    370                 375                 380                 


Gln Asp Asp Ser Gln Ala Thr Ala Glu Ala Leu Ala Leu Ala Arg Asn 
385                 390                 395                 400 


His Asp Lys Val Val Phe Val Ala Gly Leu Pro Asp Asn Tyr Glu Ser 
                405                 410                 415     


Glu Gly Phe Asp Arg Gln Asn Met Ala Leu Pro Lys Val Gln Asn Asp 
            420                 425                 430         


Leu Leu Gln Ala Val Thr Ala Val Asn Pro Asn Val Ile Val Leu Leu 
        435                 440                 445             


Val Ala Gly Ala Pro Val Glu Leu Pro Trp Val Asp Gln Val Lys Ala 
    450                 455                 460                 


Val Val Asn Leu Ser Leu Gly Gly Glu Arg Ile Gly Ala Ala Ala Ala 
465                 470                 475                 480 


Asn Val Leu Thr Gly Ala Val Asn Pro Ser Gly Lys Leu Ala Glu Ser 
                485                 490                 495     


Tyr Pro Leu Lys Tyr Gln Asp Val Pro Ser Ala Asp Val Tyr Asp Lys 
            500                 505                 510         


Lys Pro Arg Ser Val Pro Tyr Val Glu Ser Thr Tyr Ile Gly Tyr Arg 
        515                 520                 525             


Tyr Tyr Asp Lys Ala Lys Val Pro Val Ala Phe Pro Phe Gly Phe Gly 
    530                 535                 540                 


Leu Ser Tyr Thr Ser Phe Ala Leu Lys Asn Ile Gln Leu Ser Ser Asp 
545                 550                 555                 560 


His Val Thr Asp Asp Gln Pro Leu Thr Ile Ser Leu Gln Val Thr Asn 
                565                 570                 575     


Thr Gly Gln Val Asp Gly Ala Glu Val Val Gln Val Tyr Val Gln Glu 
            580                 585                 590         


Gln Gln Pro Arg Pro Leu Arg Pro Glu Lys Ser Leu Lys Ala Phe Lys 
        595                 600                 605             


Lys Val Phe Val Lys Ala Gly Gln Thr Val Asn Val Ala Leu Glu Leu 
    610                 615                 620                 


Lys Ala Gln Ala Phe Lys Glu Trp Arg Glu Gln Thr Gln Thr Trp Val 
625                 630                 635                 640 


Leu Pro Glu Ala Gln Lys Ala Ile Ala Val Gly Thr Ser Val Thr Asn 
                645                 650                 655     


Ile Asp Ala Val Leu Pro Val Ser Phe Thr Gly Glu Thr Phe Asn Asn 
            660                 665                 670         


Phe Ala Thr Ile Pro Asn Trp Tyr Thr Thr Leu Ser Gly Lys Pro Ser 
        675                 680                 685             


Val Gln Asp Phe Glu Gln Leu Thr Asp Gln Lys Val Pro Ala Pro His 
    690                 695                 700                 


Glu Phe Val Pro Gly Glu Phe Thr Arg Leu Asn Thr Pro Arg Glu Met 
705                 710                 715                 720 


Lys Lys His Ser Leu Leu Leu Arg Leu Val Ala Trp Ile Thr Val Lys 
                725                 730                 735     


Ile Arg Thr Lys Asp Tyr Ile Asp Lys Gln Gly Pro Glu Ala Lys Phe 
            740                 745                 750         


Gln Gln Ala Ile Val Leu Asp Thr Pro Leu Ile Arg Leu Ala Gln Gln 
        755                 760                 765             


Ala Ser Gly Ala Leu Lys Leu Ser Met Val Asp Arg Leu Val Ala Ala 
    770                 775                 780                 


Ala Asn His Gln Tyr Val Lys Met Ile Phe Arg 
785                 790                 795 


<210>  375
<211>  751
<212>  PRT
<213>  Lactobacillus brevis

<400>  375

Met Asp Ile Glu Arg Thr Leu Ala Glu Leu Thr Leu Pro Glu Lys Ala 
1               5                   10                  15      


Ala Leu Val Ser Gly Lys Asn Asn Trp Tyr Thr Ala Ala Val Asp Arg 
            20                  25                  30          


Leu Asp Leu Pro Ala Leu Met Met Thr Asp Gly Pro Ser Gly Leu Arg 
        35                  40                  45              


Lys Gln Ile Asn Ser Gly Thr Thr Asn Ile Asn Asp Ala Ile Gln Ala 
    50                  55                  60                  


Ile Thr Tyr Pro Ala Ala Ala Leu Ser Ala Ser Thr Trp Asn Glu Ser 
65                  70                  75                  80  


Leu Met His Gln Leu Gly Glu His Leu Gly Ile Glu Ala Arg Ala Glu 
                85                  90                  95      


Gln Val Ser Leu Leu Leu Gly Pro Gly Val Asn Met Lys Arg Ser Pro 
            100                 105                 110         


Leu Gly Gly Arg Asn Phe Glu Tyr Leu Ala Glu Asp Pro Leu Val Ala 
        115                 120                 125             


Gly Lys Leu Gly Ser Ala Tyr Val Gln Gly Val Gln Ser Gln His Val 
    130                 135                 140                 


Gly Val Ala Val Lys His Phe Ala Ala Asn Asn Arg Glu Asn Gln Arg 
145                 150                 155                 160 


Phe Thr Ala Ser Ser Asp Met Ser Glu Arg Thr Leu Arg Glu Leu Tyr 
                165                 170                 175     


Leu Arg Thr Phe Glu Ile Ile Val Lys Ser Ala Tyr Pro Ala Thr Ile 
            180                 185                 190         


Met Thr Ser Tyr Asn Lys Ile Asn Gly Val Leu Asn Ser Gln Asn Glu 
        195                 200                 205             


Arg Leu Leu Arg Arg Ile Leu Arg Asp Glu Trp Gly Phe His Gly Ala 
    210                 215                 220                 


Val Met Ser Asp Trp Gly Ala Val Ala Asn Thr Val Gln Ala Leu Lys 
225                 230                 235                 240 


Ala Gly Leu Asp Leu Glu Met Pro Gly Lys Gly Gln Ala Ser Ile Asn 
                245                 250                 255     


Asp Ile Ile Arg Ala Val His Thr Gly Glu Leu Asp Glu Gly Thr Leu 
            260                 265                 270         


Asn Lys Ala Val Arg His Leu Leu His Val Val Asp Asp Trp Leu Pro 
        275                 280                 285             


Ala Asp His Ala Gln Pro Tyr Asp His Ala Ala His His Gln Phe Ala 
    290                 295                 300                 


Arg Lys Leu Ala Asp Asp Gly Ile Ile Leu Leu Lys Asn His Glu Asp 
305                 310                 315                 320 


Glu Leu Pro Leu Asp Pro Gln Thr Thr Gly Lys Val Val Val Ile Gly 
                325                 330                 335     


Glu Leu Ala Glu Asn Pro Arg Phe Gln Gly Ser Gly Ser Ser His Val 
            340                 345                 350         


Asn Pro Thr Lys Leu Val Ser Pro Leu Asp Glu Leu Ala Gly Ser Gly 
        355                 360                 365             


Leu Lys Ala Asp Tyr Tyr Pro Gly Tyr Arg Leu Asp Gln Ser Glu Thr 
    370                 375                 380                 


Asn Gly Asp Leu Ala Glu Ala Ala Leu Thr Ala Ala Lys Thr Ala Asp 
385                 390                 395                 400 


His Val Ile Ile Phe Ala Gly Tyr Pro Glu Ala Ala Glu Ser Glu Gly 
                405                 410                 415     


Phe Asp Lys Ala Ser Leu Met Leu Pro Glu Asn Gln Ser Asp Leu Ile 
            420                 425                 430         


Gly Ser Leu Ala Lys Ala Asn Val His Thr Thr Val Val Leu Gln Asn 
        435                 440                 445             


Gly Ser Ala Val Glu Met Pro Trp Ile His Ser Val Ala Ala Val Val 
    450                 455                 460                 


Glu Thr Tyr Leu Ala Gly Glu Ala Val Gly Glu Ala Thr Trp Asp Ile 
465                 470                 475                 480 


Ile Thr Gly Ala Val Asn Pro Ser Gly His Leu Thr Glu Thr Phe Pro 
                485                 490                 495     


Arg Arg Leu Thr Asp Thr Pro Met Ala Pro Thr Phe Gly Gln Asp Pro 
            500                 505                 510         


His His Glu Tyr Tyr Thr Glu Gly Ile Phe Met Gly Tyr Arg Tyr Tyr 
        515                 520                 525             


Asp Thr His Glu Met His Val Leu Phe Pro Phe Gly His Gly Leu Ser 
    530                 535                 540                 


Tyr Thr Thr Phe Glu Tyr Thr Asn Leu Lys Leu Thr Gln Asn Glu Arg 
545                 550                 555                 560 


Gly Ala Thr Val Thr Phe Asp Val Thr Asn Thr Gly Ala Arg Ser Gly 
                565                 570                 575     


Gln Ala Val Pro Gln Leu Tyr Ile Ala Asn His Ala Ser His Val Pro 
            580                 585                 590         


Met Pro Thr Lys Glu Leu Arg Ala Phe Thr Lys Val Ala Ile Ala Pro 
        595                 600                 605             


Gly Glu Thr Glu Thr Val Thr Leu Ala Leu Asp Arg Arg Asp Phe Ser 
    610                 615                 620                 


Trp Trp Cys Glu Pro Lys Ala Arg Trp Gln Ala Asp Ser Gly Asp Tyr 
625                 630                 635                 640 


Glu Val Met Ile Gly Glu Ser Ser Arg Asp Ile Arg Leu Gln Val Lys 
                645                 650                 655     


Leu Thr Met Asp Phe Lys Asn Ser Pro Ala Pro Ile Thr Thr Glu Thr 
            660                 665                 670         


Tyr Met Ala Ala Ile Val Lys Asn Pro Gln Leu Arg Asp Leu Phe Lys 
        675                 680                 685             


Gln Val Val Leu Ala Pro Glu Tyr Ala Gly Pro Glu Asn Phe Leu Ala 
    690                 695                 700                 


Ile Thr Asp Asp Gln Gly Ser Leu Gln Ile Phe Gln Asp Arg Met Phe 
705                 710                 715                 720 


Met Asn Met Pro Leu Arg Ala Val Val Ala Leu Gly Gly Pro Gln Ala 
                725                 730                 735     


Leu Ile Thr Asp Phe Ile Thr Arg Ala Asn Thr Leu Leu Arg Gln 
            740                 745                 750     


<210>  376
<211>  838
<212>  PRT
<213>  Aspergillus fumigatus

<400>  376

Met Val Gln Leu Asp Val Glu Lys Thr Ile Glu Glu Leu Thr Leu Gly 
1               5                   10                  15      


Glu Lys Val Ala Leu Thr Ala Gly Ile Asp Phe Trp His Thr Ala Ala 
            20                  25                  30          


Val Pro Arg Leu Asn Ile Pro Ser Leu Arg Met Ser Asp Gly Pro Asn 
        35                  40                  45              


Gly Val Arg Gly Thr Arg Phe Phe Asn Gly Val Pro Ala Ala Cys Phe 
    50                  55                  60                  


Pro Cys Ala Thr Ala Leu Gly Ala Thr Trp Asp Thr Lys Leu Leu Tyr 
65                  70                  75                  80  


Glu Val Gly Arg Leu Met Gly Glu Glu Ser Ile Ala Lys Gly Ala His 
                85                  90                  95      


Val Val Leu Gly Pro Thr Ile Asn Thr Gln Arg Ser Pro Leu Gly Gly 
            100                 105                 110         


Arg Gly Phe Glu Ser Phe Ala Glu Asp Gly Val Leu Ser Gly Ile Leu 
        115                 120                 125             


Ala Gly His Tyr Cys Lys Gly Leu Gln Glu Thr Gly Val Ala Ala Thr 
    130                 135                 140                 


Leu Lys His Phe Val Cys Asn Asp Gln Glu His Glu Arg Leu Ala Val 
145                 150                 155                 160 


Asp Ser Ile Val Thr Met Arg Ala Met Arg Glu Ile Tyr Leu Leu Pro 
                165                 170                 175     


Phe Gln Leu Ala Met Arg Ile Cys Lys Thr Ala Cys Val Met Thr Ala 
            180                 185                 190         


Tyr Asn Lys Val Asn Gly Thr His Val Ser Glu Asn Lys Gln Ile Ile 
        195                 200                 205             


Thr Asp Ile Leu Arg Lys Glu Trp Gly Trp Asp Gly Leu Val Met Ser 
    210                 215                 220                 


Asp Trp Phe Gly Thr Tyr Ser Thr Cys Asp Ala Ile Asn Ala Gly Leu 
225                 230                 235                 240 


Asp Leu Glu Met Pro Gly Pro Thr Arg Trp Arg Gly Thr Ala Leu Ala 
                245                 250                 255     


His Ala Val Ser Ser Asn Lys Ala Phe Glu Phe Val Met Asp Glu Arg 
            260                 265                 270         


Val Arg Asn Ile Leu Asn Leu His Asn Phe Val Glu Pro Leu Gly Ile 
        275                 280                 285             


Pro Glu Asn Ala Pro Glu Lys Ala Leu Asn Arg Pro Glu Asp Gln Ala 
    290                 295                 300                 


Leu Leu Arg Arg Ala Ala Ala Glu Ser Val Val Leu Ile Lys Asn Gln 
305                 310                 315                 320 


Asp Asn Ile Leu Pro Leu Lys Lys Glu Lys Pro Ile Leu Val Ile Gly 
                325                 330                 335     


Pro Asn Ala Lys Thr Ala Ala Tyr Cys Gly Gly Gly Ser Ala Ser Leu 
            340                 345                 350         


Asp Ala Tyr Tyr Thr Val Thr Pro Phe Glu Gly Val Ala Ala Gln Ser 
        355                 360                 365             


Gln Gly Glu Val Thr Phe Ser Gln Gly Val Tyr Ser Tyr Lys Glu Leu 
    370                 375                 380                 


Pro Leu Leu Gly Pro Leu Leu Lys Thr Asp Asp Gly Lys Lys Gly Phe 
385                 390                 395                 400 


Lys Phe Arg Val Tyr Asn Glu Pro Pro Ser Glu Pro Asn Arg Gln Leu 
                405                 410                 415     


Ile Asp Glu Leu His Leu Glu Ser Ser Ser Gly Phe Leu Met Asp Tyr 
            420                 425                 430         


Lys His Pro Lys Ile Lys Thr Phe Thr Phe Tyr Val Asp Met Glu Gly 
        435                 440                 445             


Tyr Phe Thr Pro Glu Glu Asp Gly Ile Tyr Asp Phe Gly Val Thr Val 
    450                 455                 460                 


Val Gly Thr Gly Lys Leu Phe Val Asp Asp Glu Leu Val Val Asp Asn 
465                 470                 475                 480 


Ser Lys Asn Gln Arg Gln Gly Thr Ala Met Phe Gly Asn Ala Thr Val 
                485                 490                 495     


Glu Glu Lys Gly Ser Lys Glu Leu Lys Ala Gly Gln Thr Tyr Lys Val 
            500                 505                 510         


Val Leu Gln Phe Gly Thr Ala Pro Thr Ser Asp Leu Asp Met Arg Gly 
        515                 520                 525             


Val Val Ile Phe Gly Pro Gly Gly Phe Arg Phe Gly Ala Ala Arg Arg 
    530                 535                 540                 


Val Ser Gln Glu Glu Leu Ile Ser Lys Ala Ala Glu Leu Ala Ser Gln 
545                 550                 555                 560 


Thr Ser Gln Val Val Ile Phe Ala Gly Leu Thr Ser Glu Trp Glu Thr 
                565                 570                 575     


Glu Gly Tyr Asp Arg Asp His Met Asp Leu Pro Pro Gly Ser Asp Glu 
            580                 585                 590         


Met Ile Ser Arg Val Leu Asp Ala Asn Pro Asp Thr Val Val Val Ile 
        595                 600                 605             


Gln Ser Gly Thr Pro Val Thr Met Pro Trp Ala His Lys Ala Lys Ala 
    610                 615                 620                 


Leu Leu Gln Ala Trp Phe Gly Gly Asn Glu Cys Gly Asn Gly Ile Ala 
625                 630                 635                 640 


Asp Val Leu Tyr Gly Asn Val Asn Pro Ala Ala Lys Leu Pro Leu Ser 
                645                 650                 655     


Phe Pro Val Arg Leu Gln Asp Asn Pro Ser Tyr Leu Asn Phe Arg Ser 
            660                 665                 670         


Glu Arg Gly Arg Val Leu Tyr Gly Glu Asp Ile Tyr Val Gly Tyr Arg 
        675                 680                 685             


Tyr Tyr Glu Lys Val Asp Leu Ala Pro Leu Phe Pro Phe Gly His Gly 
    690                 695                 700                 


Leu Ser Tyr Thr Thr Phe Ser Arg Ser Asp Leu Ser Leu Ala Thr Thr 
705                 710                 715                 720 


Pro Glu Lys Pro Gln Leu Glu Asp Gly Glu Pro Ile Thr Val Thr Val 
                725                 730                 735     


Ser Val Thr Asn Thr Gly Ser Val Ala Gly Ala Glu Ile Val Gln Leu 
            740                 745                 750         


Trp Val Ala Pro Pro Pro Thr Gly Val Asn Arg Pro Val Arg Glu Leu 
        755                 760                 765             


Lys Gly Phe Thr Lys Val Phe Leu Gln Pro Gly Glu Thr Lys Lys Val 
    770                 775                 780                 


Glu Ile Val Val Glu Lys Lys Leu Ala Thr Ser Trp Trp Asp Glu Gln 
785                 790                 795                 800 


Arg Glu Lys Trp Ala Ser Glu Lys Gly Thr Tyr Glu Val Leu Val Thr 
                805                 810                 815     


Gly Thr Gly Asp Glu Val Leu Lys Ser Ser Phe Glu Val Glu Lys Thr 
            820                 825                 830         


Arg Tyr Trp Leu Gly Leu 
        835             


<210>  377
<211>  2274
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 370

<400>  377
ttgtcgtata aagatctcgt ctcgcgcctc accctcgaag aaaaagcatc cctctgctcc     60

gggctcaact tctggcaaac gaagcccatc gagcgcctcg gcatcccgtc tctctgcatg    120

acggacgggc cgcacggcgt tcggctgcag cggcagggcg gatcgttcac cgattcggag    180

cccgccacgt gcttcccgac agccgccgcg ctcgcgagtt cctgggatcc cgcgctcgtg    240

gagcggattg gccaggcgct cggcgacgaa tgccgcgcgc tcggcgttca cgtgttgctc    300

gggcccggcg ccaacatcaa gcgatctccc ttgtgcgggc gcaacttcga gtacttctcg    360

gaggatccgc ttctctcgag cgaaatggcc gcggcgcata tccggggcgt ccagtcgcgc    420

ggcgtcggat cgtcgctcaa gcactttgct gccaacaacc aggagtaccg gcgcatgacg    480

acgagcgccg aggtggacga gcgcacgctg cgcgagatct atctcgcgag cttcgaaggc    540

gccgtcaagg gtggacgccc gtggacggtc atgtgcgcgt acaatcgcct caacggcacc    600

tactgctcgg aacacccgtg gcttctcacg caggtgctgc gccgggaatg gggatttgat    660

ggcgtcgtgg tgtcggactg gggggcggtg aacgatcgcg tccaaggcct cgctgcaggg    720

ctggacctcg aaatgcccgg cgggccgtac gcgcaggacg ccgagatcgt ccaggctgtg    780

cgagacggtc gcctggacga agccgtgctc gatgcggccg tggaacgcct gctcgcgctc    840

atcgaccggg cctaccggcc gcagggcgat tccgccgatc tcgacgcgca tcaccgcctt    900

gcccgccagg ccgcggccga gtcgatggtg cttctgaaga acgacggggc cgtgttgccc    960

atcgcgccag ggcggcgggt ggcggtgatt ggcgcgttcg ccgtgtcgcc gcgctaccag   1020

ggaggaggaa gctcgcacgt caatcccgcg cgcctcgacg agccgctcgc ggagatgcgc   1080

cgcgcgtttg gcgaccagct tgtcctgtac gcgccggggt acgcgctcga cgacgacgcg   1140

cctcgcctcg agctcatcga ggaggccgtg cgcgctgcgg cgcaggcgga tgtcgccgcc   1200

atctttgcag ggctgccgga gagctgggag tctgaaggat atgatcgccc gcacatgcga   1260

atgccggacg cgcacgtggc gctcatcgaa gcggtgacgt cggctcagcc ccgcacggtt   1320

gtcgtgctct cgaacggcgc gcccgtcgag atgccttgga tccaccgcgt gcctgccgtg   1380

atcgaggcgt atctcgcggg gcaggccttc ggcggcgcca tcgcggacgt gctgtcgggc   1440

gctgtgaacc cgtccggcaa gctggccgag acgtttccgc ttcggctcga gcacaaccct   1500

tcgcatccat acttccccgg cgaaggcgac agatccgaat accgagaagg tgtcttcgtc   1560

ggctatcgct actacgacac caaggagatg gacgtgctgt ttcccttcgg gcacgggctg   1620

tcgtacacca cgttcgagta cgaggccatc cgcatgtctc gtgagcaggt ccgggacgac   1680

gacgtgctca ccgtgcaggt ggacgtgcgc aataccgggc agcgcgcggg caaagaggtg   1740

gtccaggtct atgtcgagcc gaggtcctcg cgagtcgttc gacctcggcg cgagcttcgc   1800

gccttcgcca aggtggcgct ggcacccggc gagacgcgta cggtcgaatt tcagctgggc   1860

aagcgcgcgt ttgcctacta cgacgtcgat gctggcgatt tcgccgtgga gagcggctgg   1920

tacgagatcc gcgtcggatc gtcctcgcgt gatctgcgcc tcaccgcctc cgtggaggtg   1980

acatccgccg ccccgcgcag gccggtgtcg gtccacgcca atgcagcgct gggcgatctg   2040

ctggacgatc cggccaccgg tccggtgctc cgcgagctct tgaaggagaa gctcgccgat   2100

tcgccgcttg gcagcgagat ggacgccaat ccgatgttcg aggcgttcat gcggttcacg   2160

cccatcggtc gtgtcacgac gctgtttggg gtgccgcggg acgagaacga gcgagttctt   2220

gcgaagctgc gagccgcgca ggaagagggc caaccggagg aagggcgggg gtga         2274


<210>  378
<211>  2274
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 370

<400>  378
ttgtcgtatc gcgagctcgt ctcgcgcctc accctcgaag aaaaagcatc cctctgctcc     60

gggctcaact tctggcaaac gaagcccatc gagcgcctcg gcatcccgtc tctctgcatg    120

acggacgggc cgcacggcgt tcggctgcag cggcagggcg gatcgttcac cgattcggag    180

cccgccacgt gcttcccgac agccgccgcg ctcgcgagtt cctgggatcc cgcgctcgtg    240

gagcggattg gccaggcgct cggcgacgaa tgccgcgcgc tcggcgttca cgtgttgctc    300

gggcccggcg ccaacatcaa gcgatctccc ttgtgcgggc gcaacttcga gtacttctcg    360

gaggatccgc ttctctcgag cgaaatggcc gcggcgcata tccggggcgt ccagtcgcgc    420

ggcgtcggat cgtcgctcaa gcactttgct gccaacaacc aggagtaccg gcgcatgacg    480

acgagcgccg aggtggacga gcgcacgctg cgcgagatct atctcgcgag cttcgaaggc    540

gccgtcaagg gtggacgccc gtggacggtc atgtgcgcgt acaatcgcct caacggcacc    600

tactgctcgg aacacccgtg gcttctcacg caggtgctgc gccgggaatg gggatttgat    660

ggcgtcgtgg tgtcggactg gggggcggtg aacgatcgcg tccaaggcct cgctgcaggg    720

ctggacctcg aaatgcccgg cgggccgtac gcgcaggacg ccgagatcgt ccaggctgtg    780

cgagacggtc gcctggacga agccgtgctc gatgcggccg tggaacgcct gctcgcgctc    840

atcgaccggg cctaccggcc gcagggcgat tccgccgatc tcgacgcgca tcaccgcctt    900

gcccgccagg ccgcggccga gtcgatggtg cttctgaaga acgacggggc cgtgttgccc    960

atcgcgccag ggcggcgggt ggcggtgatt ggcgcgttcg ccgtgtcgcc gcgctaccag   1020

ggaggaggaa gctcgcacgt caatcccgcg cgcctcgacg agccgctcgc ggagatgcgc   1080

cgcgcgtttg gcgaccagct tgtcctgtac gcgccggggt acgcgctcga cgacgacgcg   1140

cctcgcctcg agctcatcga ggaggccgtg cgcgctgcgg cgcaggcgga tgtcgccgcc   1200

atctttgcag ggctgccgga gagctgggag tctgaaggat atgatcgccc gcacatgcga   1260

atgccggacg cgcacgtggc gctcatcgaa gcggtgacgt cggctcagcc ccgcacggtt   1320

gtcgtgctct cgaacggcgc gcccgtcgag atgccttgga tccaccgcgt gcctgccgtg   1380

atcgaggcgt atctcgcggg gcaggccttc ggcggcgcca tcgcggacgt gctgtcgggc   1440

gctgtgaacc cgtccggcaa gctggccgag acgtttccgc ttcggctcga gcacaaccct   1500

tcgcatccat acttccccgg cgaaggcgac agatccgaat accgagaagg tgtcttcgtc   1560

ggctatcgct actacgacac caaggagatg gacgtgctgt ttcccttcgg gcacgggctg   1620

tcgtacacca cgttcgagta cgaggccatc cgcatgtctc gtgagcaggt ccgggacgac   1680

gacgtgctca ccgtgcaggt ggacgtgcgc aataccgggc agcgcgcggg caaagaggtg   1740

gtccaggtct atgtcgagcc gaggtcctcg cgagtcgttc gacctcggcg cgagcttcgc   1800

gccttcgcca aggtggcgct ggcacccggc gagacgcgta cggtcgaatt tcagctgggc   1860

aagcgcgcgt ttgcctacta cgacgtcgat gctggcgatt tcgccgtgga gagcggctgg   1920

tacgagatcc gcgtcggatc gtcctcgcgt gatctgcgcc tcaccgcctc cgtggaggtg   1980

acatccgccg ccccgcgcag gccggtgtcg gtccacgcca atgcagcgct gggcgatctg   2040

ctggacgatc cggccaccgg tccggtgctc cgcgagctct tgaaggagaa gctcgccgat   2100

tcgccgcttg gcagcgagat ggacgccaat ccgatgttcg aggcgttcat gcggttcacg   2160

cccatcggtc gtgtcacgac gctgtttggg gtgccgcggg acgagaacga gcgagttctt   2220

gcgaagctgc gagccgcgca ggaagagggc caaccggagg aagggcgggg gtga         2274


<210>  379
<211>  2274
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 370

<400>  379
ttgtcgtatc gcgatatcgt ctcgcgcctc accctcgaag aaaaagcatc cctctgctcc     60

gggctcaact tctggcaaac gaagcccatc gagcgcctcg gcatcccgtc tctctgcatg    120

acggacgggc cgcacggcgt tcggctgcag cggcagggcg gatcgttcac cgattcggag    180

cccgccacgt gcttcccgac agccgccgcg ctcgcgagtt cctgggatcc cgcgctcgtg    240

gagcggattg gccaggcgct cggcgacgaa tgccgcgcgc tcggcgttca cgtgttgctc    300

gggcccggcg ccaacatcaa gcgatctccc ttgtgcgggc gcaacttcga gtacttctcg    360

gaggatccgc ttctctcgag cgaaatggcc gcggcgcata tccggggcgt ccagtcgcgc    420

ggcgtcggat cgtcgctcaa gcactttgct gccaacaacc aggagtaccg gcgcatgacg    480

acgagcgccg aggtggacga gcgcacgctg cgcgagatct atctcgcgag cttcgaaggc    540

gccgtcaagg gtggacgccc gtggacggtc atgtgcgcgt acaatcgcct caacggcacc    600

tactgctcgg aacacccgtg gcttctcacg caggtgctgc gccgggaatg gggatttgat    660

ggcgtcgtgg tgtcggactg gggggcggtg aacgatcgcg tccaaggcct cgctgcaggg    720

ctggacctcg aaatgcccgg cgggccgtac gcgcaggacg ccgagatcgt ccaggctgtg    780

cgagacggtc gcctggacga agccgtgctc gatgcggccg tggaacgcct gctcgcgctc    840

atcgaccggg cctaccggcc gcagggcgat tccgccgatc tcgacgcgca tcaccgcctt    900

gcccgccagg ccgcggccga gtcgatggtg cttctgaaga acgacggggc cgtgttgccc    960

atcgcgccag ggcggcgggt ggcggtgatt ggcgcgttcg ccgtgtcgcc gcgctaccag   1020

ggaggaggaa gctcgcacgt caatcccgcg cgcctcgacg agccgctcgc ggagatgcgc   1080

cgcgcgtttg gcgaccagct tgtcctgtac gcgccggggt acgcgctcga cgacgacgcg   1140

cctcgcctcg agctcatcga ggaggccgtg cgcgctgcgg cgcaggcgga tgtcgccgcc   1200

atctttgcag ggctgccgga gagctgggag tctgaaggat atgatcgccc gcacatgcga   1260

atgccggacg cgcacgtggc gctcatcgaa gcggtgacgt cggctcagcc ccgcacggtt   1320

gtcgtgctct cgaacggcgc gcccgtcgag atgccttgga tccaccgcgt gcctgccgtg   1380

atcgaggcgt atctcgcggg gcaggccttc ggcggcgcca tcgcggacgt gctgtcgggc   1440

gctgtgaacc cgtccggcaa gctggccgag acgtttccgc ttcggctcga gcacaaccct   1500

tcgcatccat acttccccgg cgaaggcgac agatccgaat accgagaagg tgtcttcgtc   1560

ggctatcgct actacgacac caaggagatg gacgtgctgt ttcccttcgg gcacgggctg   1620

tcgtacacca cgttcgagta cgaggccatc cgcatgtctc gtgagcaggt ccgggacgac   1680

gacgtgctca ccgtgcaggt ggacgtgcgc aataccgggc agcgcgcggg caaagaggtg   1740

gtccaggtct atgtcgagcc gaggtcctcg cgagtcgttc gacctcggcg cgagcttcgc   1800

gccttcgcca aggtggcgct ggcacccggc gagacgcgta cggtcgaatt tcagctgggc   1860

aagcgcgcgt ttgcctacta cgacgtcgat gctggcgatt tcgccgtgga gagcggctgg   1920

tacgagatcc gcgtcggatc gtcctcgcgt gatctgcgcc tcaccgcctc cgtggaggtg   1980

acatccgccg ccccgcgcag gccggtgtcg gtccacgcca atgcagcgct gggcgatctg   2040

ctggacgatc cggccaccgg tccggtgctc cgcgagctct tgaaggagaa gctcgccgat   2100

tcgccgcttg gcagcgagat ggacgccaat ccgatgttcg aggcgttcat gcggttcacg   2160

cccatcggtc gtgtcacgac gctgtttggg gtgccgcggg acgagaacga gcgagttctt   2220

gcgaagctgc gagccgcgca ggaagagggc caaccggagg aagggcgggg gtga         2274


<210>  380
<211>  2274
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 370

<400>  380
ttgtcgtatc gcgatgtcgt ctcgcgcctc accctcgaag aaaaagcatc cctctgctcc     60

gggctcaact tctggcaaac gaagcccatc gagcgcctcg gcatcccgtc tctctgcatg    120

acggacgggc cgcacggcgt tcggctgcag cggcagggcg gatcgttcac cgattcggag    180

cccgccacgt gcttcccgac agccgccgcg ctcgcgagtt cctgggatcc cgcgctcgtg    240

gagcggattg gccaggcgct cggcgacgaa tgccgcgcgc tcggcgttca cgtgttgctc    300

gggcccggcg ccaacatcaa gcgatctccc ttgtgcgggc gcaacttcga gtacttctcg    360

gaggatccgc ttctctcgag cgaaatggcc gcggcgcata tccggggcgt ccagtcgcgc    420

ggcgtcggat cgtcgctcaa gcactttgct gccaacaacc aggagtaccg gcgcatgacg    480

acgagcgccg aggtggacga gcgcacgctg cgcgagatct atctcgcgag cttcgaaggc    540

gccgtcaagg gtggacgccc gtggacggtc atgtgcgcgt acaatcgcct caacggcacc    600

tactgctcgg aacacccgtg gcttctcacg caggtgctgc gccgggaatg gggatttgat    660

ggcgtcgtgg tgtcggactg gggggcggtg aacgatcgcg tccaaggcct cgctgcaggg    720

ctggacctcg aaatgcccgg cgggccgtac gcgcaggacg ccgagatcgt ccaggctgtg    780

cgagacggtc gcctggacga agccgtgctc gatgcggccg tggaacgcct gctcgcgctc    840

atcgaccggg cctaccggcc gcagggcgat tccgccgatc tcgacgcgca tcaccgcctt    900

gcccgccagg ccgcggccga gtcgatggtg cttctgaaga acgacggggc cgtgttgccc    960

atcgcgccag ggcggcgggt ggcggtgatt ggcgcgttcg ccgtgtcgcc gcgctaccag   1020

ggaggaggaa gctcgcacgt caatcccgcg cgcctcgacg agccgctcgc ggagatgcgc   1080

cgcgcgtttg gcgaccagct tgtcctgtac gcgccggggt acgcgctcga cgacgacgcg   1140

cctcgcctcg agctcatcga ggaggccgtg cgcgctgcgg cgcaggcgga tgtcgccgcc   1200

atctttgcag ggctgccgga gagctgggag tctgaaggat atgatcgccc gcacatgcga   1260

atgccggacg cgcacgtggc gctcatcgaa gcggtgacgt cggctcagcc ccgcacggtt   1320

gtcgtgctct cgaacggcgc gcccgtcgag atgccttgga tccaccgcgt gcctgccgtg   1380

atcgaggcgt atctcgcggg gcaggccttc ggcggcgcca tcgcggacgt gctgtcgggc   1440

gctgtgaacc cgtccggcaa gctggccgag acgtttccgc ttcggctcga gcacaaccct   1500

tcgcatccat acttccccgg cgaaggcgac agatccgaat accgagaagg tgtcttcgtc   1560

ggctatcgct actacgacac caaggagatg gacgtgctgt ttcccttcgg gcacgggctg   1620

tcgtacacca cgttcgagta cgaggccatc cgcatgtctc gtgagcaggt ccgggacgac   1680

gacgtgctca ccgtgcaggt ggacgtgcgc aataccgggc agcgcgcggg caaagaggtg   1740

gtccaggtct atgtcgagcc gaggtcctcg cgagtcgttc gacctcggcg cgagcttcgc   1800

gccttcgcca aggtggcgct ggcacccggc gagacgcgta cggtcgaatt tcagctgggc   1860

aagcgcgcgt ttgcctacta cgacgtcgat gctggcgatt tcgccgtgga gagcggctgg   1920

tacgagatcc gcgtcggatc gtcctcgcgt gatctgcgcc tcaccgcctc cgtggaggtg   1980

acatccgccg ccccgcgcag gccggtgtcg gtccacgcca atgcagcgct gggcgatctg   2040

ctggacgatc cggccaccgg tccggtgctc cgcgagctct tgaaggagaa gctcgccgat   2100

tcgccgcttg gcagcgagat ggacgccaat ccgatgttcg aggcgttcat gcggttcacg   2160

cccatcggtc gtgtcacgac gctgtttggg gtgccgcggg acgagaacga gcgagttctt   2220

gcgaagctgc gagccgcgca ggaagagggc caaccggagg aagggcgggg gtga         2274


<210>  381
<211>  2274
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 370

<400>  381
ttgtcgtatc gcgatctcct ctcgcgcctc accctcgaag aaaaagcatc cctctgctcc     60

gggctcaact tctggcaaac gaagcccatc gagcgcctcg gcatcccgtc tctctgcatg    120

acggacgggc cgcacggcgt tcggctgcag cggcagggcg gatcgttcac cgattcggag    180

cccgccacgt gcttcccgac agccgccgcg ctcgcgagtt cctgggatcc cgcgctcgtg    240

gagcggattg gccaggcgct cggcgacgaa tgccgcgcgc tcggcgttca cgtgttgctc    300

gggcccggcg ccaacatcaa gcgatctccc ttgtgcgggc gcaacttcga gtacttctcg    360

gaggatccgc ttctctcgag cgaaatggcc gcggcgcata tccggggcgt ccagtcgcgc    420

ggcgtcggat cgtcgctcaa gcactttgct gccaacaacc aggagtaccg gcgcatgacg    480

acgagcgccg aggtggacga gcgcacgctg cgcgagatct atctcgcgag cttcgaaggc    540

gccgtcaagg gtggacgccc gtggacggtc atgtgcgcgt acaatcgcct caacggcacc    600

tactgctcgg aacacccgtg gcttctcacg caggtgctgc gccgggaatg gggatttgat    660

ggcgtcgtgg tgtcggactg gggggcggtg aacgatcgcg tccaaggcct cgctgcaggg    720

ctggacctcg aaatgcccgg cgggccgtac gcgcaggacg ccgagatcgt ccaggctgtg    780

cgagacggtc gcctggacga agccgtgctc gatgcggccg tggaacgcct gctcgcgctc    840

atcgaccggg cctaccggcc gcagggcgat tccgccgatc tcgacgcgca tcaccgcctt    900

gcccgccagg ccgcggccga gtcgatggtg cttctgaaga acgacggggc cgtgttgccc    960

atcgcgccag ggcggcgggt ggcggtgatt ggcgcgttcg ccgtgtcgcc gcgctaccag   1020

ggaggaggaa gctcgcacgt caatcccgcg cgcctcgacg agccgctcgc ggagatgcgc   1080

cgcgcgtttg gcgaccagct tgtcctgtac gcgccggggt acgcgctcga cgacgacgcg   1140

cctcgcctcg agctcatcga ggaggccgtg cgcgctgcgg cgcaggcgga tgtcgccgcc   1200

atctttgcag ggctgccgga gagctgggag tctgaaggat atgatcgccc gcacatgcga   1260

atgccggacg cgcacgtggc gctcatcgaa gcggtgacgt cggctcagcc ccgcacggtt   1320

gtcgtgctct cgaacggcgc gcccgtcgag atgccttgga tccaccgcgt gcctgccgtg   1380

atcgaggcgt atctcgcggg gcaggccttc ggcggcgcca tcgcggacgt gctgtcgggc   1440

gctgtgaacc cgtccggcaa gctggccgag acgtttccgc ttcggctcga gcacaaccct   1500

tcgcatccat acttccccgg cgaaggcgac agatccgaat accgagaagg tgtcttcgtc   1560

ggctatcgct actacgacac caaggagatg gacgtgctgt ttcccttcgg gcacgggctg   1620

tcgtacacca cgttcgagta cgaggccatc cgcatgtctc gtgagcaggt ccgggacgac   1680

gacgtgctca ccgtgcaggt ggacgtgcgc aataccgggc agcgcgcggg caaagaggtg   1740

gtccaggtct atgtcgagcc gaggtcctcg cgagtcgttc gacctcggcg cgagcttcgc   1800

gccttcgcca aggtggcgct ggcacccggc gagacgcgta cggtcgaatt tcagctgggc   1860

aagcgcgcgt ttgcctacta cgacgtcgat gctggcgatt tcgccgtgga gagcggctgg   1920

tacgagatcc gcgtcggatc gtcctcgcgt gatctgcgcc tcaccgcctc cgtggaggtg   1980

acatccgccg ccccgcgcag gccggtgtcg gtccacgcca atgcagcgct gggcgatctg   2040

ctggacgatc cggccaccgg tccggtgctc cgcgagctct tgaaggagaa gctcgccgat   2100

tcgccgcttg gcagcgagat ggacgccaat ccgatgttcg aggcgttcat gcggttcacg   2160

cccatcggtc gtgtcacgac gctgtttggg gtgccgcggg acgagaacga gcgagttctt   2220

gcgaagctgc gagccgcgca ggaagagggc caaccggagg aagggcgggg gtga         2274


<210>  382
<211>  757
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:371 and encoded by SEQ ID NO:377

<400>  382

Met Ser Tyr Lys Asp Leu Val Ser Arg Leu Thr Leu Glu Glu Lys Ala 
1               5                   10                  15      


Ser Leu Cys Ser Gly Leu Asn Phe Trp Gln Thr Lys Pro Ile Glu Arg 
            20                  25                  30          


Leu Gly Ile Pro Ser Leu Cys Met Thr Asp Gly Pro His Gly Val Arg 
        35                  40                  45              


Leu Gln Arg Gln Gly Gly Ser Phe Thr Asp Ser Glu Pro Ala Thr Cys 
    50                  55                  60                  


Phe Pro Thr Ala Ala Ala Leu Ala Ser Ser Trp Asp Pro Ala Leu Val 
65                  70                  75                  80  


Glu Arg Ile Gly Gln Ala Leu Gly Asp Glu Cys Arg Ala Leu Gly Val 
                85                  90                  95      


His Val Leu Leu Gly Pro Gly Ala Asn Ile Lys Arg Ser Pro Leu Cys 
            100                 105                 110         


Gly Arg Asn Phe Glu Tyr Phe Ser Glu Asp Pro Leu Leu Ser Ser Glu 
        115                 120                 125             


Met Ala Ala Ala His Ile Arg Gly Val Gln Ser Arg Gly Val Gly Ser 
    130                 135                 140                 


Ser Leu Lys His Phe Ala Ala Asn Asn Gln Glu Tyr Arg Arg Met Thr 
145                 150                 155                 160 


Thr Ser Ala Glu Val Asp Glu Arg Thr Leu Arg Glu Ile Tyr Leu Ala 
                165                 170                 175     


Ser Phe Glu Gly Ala Val Lys Gly Gly Arg Pro Trp Thr Val Met Cys 
            180                 185                 190         


Ala Tyr Asn Arg Leu Asn Gly Thr Tyr Cys Ser Glu His Pro Trp Leu 
        195                 200                 205             


Leu Thr Gln Val Leu Arg Arg Glu Trp Gly Phe Asp Gly Val Val Val 
    210                 215                 220                 


Ser Asp Trp Gly Ala Val Asn Asp Arg Val Gln Gly Leu Ala Ala Gly 
225                 230                 235                 240 


Leu Asp Leu Glu Met Pro Gly Gly Pro Tyr Ala Gln Asp Ala Glu Ile 
                245                 250                 255     


Val Gln Ala Val Arg Asp Gly Arg Leu Asp Glu Ala Val Leu Asp Ala 
            260                 265                 270         


Ala Val Glu Arg Leu Leu Ala Leu Ile Asp Arg Ala Tyr Arg Pro Gln 
        275                 280                 285             


Gly Asp Ser Ala Asp Leu Asp Ala His His Arg Leu Ala Arg Gln Ala 
    290                 295                 300                 


Ala Ala Glu Ser Met Val Leu Leu Lys Asn Asp Gly Ala Val Leu Pro 
305                 310                 315                 320 


Ile Ala Pro Gly Arg Arg Val Ala Val Ile Gly Ala Phe Ala Val Ser 
                325                 330                 335     


Pro Arg Tyr Gln Gly Gly Gly Ser Ser His Val Asn Pro Ala Arg Leu 
            340                 345                 350         


Asp Glu Pro Leu Ala Glu Met Arg Arg Ala Phe Gly Asp Gln Leu Val 
        355                 360                 365             


Leu Tyr Ala Pro Gly Tyr Ala Leu Asp Asp Asp Ala Pro Arg Leu Glu 
    370                 375                 380                 


Leu Ile Glu Glu Ala Val Arg Ala Ala Ala Gln Ala Asp Val Ala Ala 
385                 390                 395                 400 


Ile Phe Ala Gly Leu Pro Glu Ser Trp Glu Ser Glu Gly Tyr Asp Arg 
                405                 410                 415     


Pro His Met Arg Met Pro Asp Ala His Val Ala Leu Ile Glu Ala Val 
            420                 425                 430         


Thr Ser Ala Gln Pro Arg Thr Val Val Val Leu Ser Asn Gly Ala Pro 
        435                 440                 445             


Val Glu Met Pro Trp Ile His Arg Val Pro Ala Val Ile Glu Ala Tyr 
    450                 455                 460                 


Leu Ala Gly Gln Ala Phe Gly Gly Ala Ile Ala Asp Val Leu Ser Gly 
465                 470                 475                 480 


Ala Val Asn Pro Ser Gly Lys Leu Ala Glu Thr Phe Pro Leu Arg Leu 
                485                 490                 495     


Glu His Asn Pro Ser His Pro Tyr Phe Pro Gly Glu Gly Asp Arg Ser 
            500                 505                 510         


Glu Tyr Arg Glu Gly Val Phe Val Gly Tyr Arg Tyr Tyr Asp Thr Lys 
        515                 520                 525             


Glu Met Asp Val Leu Phe Pro Phe Gly His Gly Leu Ser Tyr Thr Thr 
    530                 535                 540                 


Phe Glu Tyr Glu Ala Ile Arg Met Ser Arg Glu Gln Val Arg Asp Asp 
545                 550                 555                 560 


Asp Val Leu Thr Val Gln Val Asp Val Arg Asn Thr Gly Gln Arg Ala 
                565                 570                 575     


Gly Lys Glu Val Val Gln Val Tyr Val Glu Pro Arg Ser Ser Arg Val 
            580                 585                 590         


Val Arg Pro Arg Arg Glu Leu Arg Ala Phe Ala Lys Val Ala Leu Ala 
        595                 600                 605             


Pro Gly Glu Thr Arg Thr Val Glu Phe Gln Leu Gly Lys Arg Ala Phe 
    610                 615                 620                 


Ala Tyr Tyr Asp Val Asp Ala Gly Asp Phe Ala Val Glu Ser Gly Trp 
625                 630                 635                 640 


Tyr Glu Ile Arg Val Gly Ser Ser Ser Arg Asp Leu Arg Leu Thr Ala 
                645                 650                 655     


Ser Val Glu Val Thr Ser Ala Ala Pro Arg Arg Pro Val Ser Val His 
            660                 665                 670         


Ala Asn Ala Ala Leu Gly Asp Leu Leu Asp Asp Pro Ala Thr Gly Pro 
        675                 680                 685             


Val Leu Arg Glu Leu Leu Lys Glu Lys Leu Ala Asp Ser Pro Leu Gly 
    690                 695                 700                 


Ser Glu Met Asp Ala Asn Pro Met Phe Glu Ala Phe Met Arg Phe Thr 
705                 710                 715                 720 


Pro Ile Gly Arg Val Thr Thr Leu Phe Gly Val Pro Arg Asp Glu Asn 
                725                 730                 735     


Glu Arg Val Leu Ala Lys Leu Arg Ala Ala Gln Glu Glu Gly Gln Pro 
            740                 745                 750         


Glu Glu Gly Arg Gly 
        755         


<210>  383
<211>  758
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:371 and encoded by SEQ ID NO:378

<400>  383

Met Ser Tyr Arg Glu Asp Leu Val Ser Arg Leu Thr Leu Glu Glu Lys 
1               5                   10                  15      


Ala Ser Leu Cys Ser Gly Leu Asn Phe Trp Gln Thr Lys Pro Ile Glu 
            20                  25                  30          


Arg Leu Gly Ile Pro Ser Leu Cys Met Thr Asp Gly Pro His Gly Val 
        35                  40                  45              


Arg Leu Gln Arg Gln Gly Gly Ser Phe Thr Asp Ser Glu Pro Ala Thr 
    50                  55                  60                  


Cys Phe Pro Thr Ala Ala Ala Leu Ala Ser Ser Trp Asp Pro Ala Leu 
65                  70                  75                  80  


Val Glu Arg Ile Gly Gln Ala Leu Gly Asp Glu Cys Arg Ala Leu Gly 
                85                  90                  95      


Val His Val Leu Leu Gly Pro Gly Ala Asn Ile Lys Arg Ser Pro Leu 
            100                 105                 110         


Cys Gly Arg Asn Phe Glu Tyr Phe Ser Glu Asp Pro Leu Leu Ser Ser 
        115                 120                 125             


Glu Met Ala Ala Ala His Ile Arg Gly Val Gln Ser Arg Gly Val Gly 
    130                 135                 140                 


Ser Ser Leu Lys His Phe Ala Ala Asn Asn Gln Glu Tyr Arg Arg Met 
145                 150                 155                 160 


Thr Thr Ser Ala Glu Val Asp Glu Arg Thr Leu Arg Glu Ile Tyr Leu 
                165                 170                 175     


Ala Ser Phe Glu Gly Ala Val Lys Gly Gly Arg Pro Trp Thr Val Met 
            180                 185                 190         


Cys Ala Tyr Asn Arg Leu Asn Gly Thr Tyr Cys Ser Glu His Pro Trp 
        195                 200                 205             


Leu Leu Thr Gln Val Leu Arg Arg Glu Trp Gly Phe Asp Gly Val Val 
    210                 215                 220                 


Val Ser Asp Trp Gly Ala Val Asn Asp Arg Val Gln Gly Leu Ala Ala 
225                 230                 235                 240 


Gly Leu Asp Leu Glu Met Pro Gly Gly Pro Tyr Ala Gln Asp Ala Glu 
                245                 250                 255     


Ile Val Gln Ala Val Arg Asp Gly Arg Leu Asp Glu Ala Val Leu Asp 
            260                 265                 270         


Ala Ala Val Glu Arg Leu Leu Ala Leu Ile Asp Arg Ala Tyr Arg Pro 
        275                 280                 285             


Gln Gly Asp Ser Ala Asp Leu Asp Ala His His Arg Leu Ala Arg Gln 
    290                 295                 300                 


Ala Ala Ala Glu Ser Met Val Leu Leu Lys Asn Asp Gly Ala Val Leu 
305                 310                 315                 320 


Pro Ile Ala Pro Gly Arg Arg Val Ala Val Ile Gly Ala Phe Ala Val 
                325                 330                 335     


Ser Pro Arg Tyr Gln Gly Gly Gly Ser Ser His Val Asn Pro Ala Arg 
            340                 345                 350         


Leu Asp Glu Pro Leu Ala Glu Met Arg Arg Ala Phe Gly Asp Gln Leu 
        355                 360                 365             


Val Leu Tyr Ala Pro Gly Tyr Ala Leu Asp Asp Asp Ala Pro Arg Leu 
    370                 375                 380                 


Glu Leu Ile Glu Glu Ala Val Arg Ala Ala Ala Gln Ala Asp Val Ala 
385                 390                 395                 400 


Ala Ile Phe Ala Gly Leu Pro Glu Ser Trp Glu Ser Glu Gly Tyr Asp 
                405                 410                 415     


Arg Pro His Met Arg Met Pro Asp Ala His Val Ala Leu Ile Glu Ala 
            420                 425                 430         


Val Thr Ser Ala Gln Pro Arg Thr Val Val Val Leu Ser Asn Gly Ala 
        435                 440                 445             


Pro Val Glu Met Pro Trp Ile His Arg Val Pro Ala Val Ile Glu Ala 
    450                 455                 460                 


Tyr Leu Ala Gly Gln Ala Phe Gly Gly Ala Ile Ala Asp Val Leu Ser 
465                 470                 475                 480 


Gly Ala Val Asn Pro Ser Gly Lys Leu Ala Glu Thr Phe Pro Leu Arg 
                485                 490                 495     


Leu Glu His Asn Pro Ser His Pro Tyr Phe Pro Gly Glu Gly Asp Arg 
            500                 505                 510         


Ser Glu Tyr Arg Glu Gly Val Phe Val Gly Tyr Arg Tyr Tyr Asp Thr 
        515                 520                 525             


Lys Glu Met Asp Val Leu Phe Pro Phe Gly His Gly Leu Ser Tyr Thr 
    530                 535                 540                 


Thr Phe Glu Tyr Glu Ala Ile Arg Met Ser Arg Glu Gln Val Arg Asp 
545                 550                 555                 560 


Asp Asp Val Leu Thr Val Gln Val Asp Val Arg Asn Thr Gly Gln Arg 
                565                 570                 575     


Ala Gly Lys Glu Val Val Gln Val Tyr Val Glu Pro Arg Ser Ser Arg 
            580                 585                 590         


Val Val Arg Pro Arg Arg Glu Leu Arg Ala Phe Ala Lys Val Ala Leu 
        595                 600                 605             


Ala Pro Gly Glu Thr Arg Thr Val Glu Phe Gln Leu Gly Lys Arg Ala 
    610                 615                 620                 


Phe Ala Tyr Tyr Asp Val Asp Ala Gly Asp Phe Ala Val Glu Ser Gly 
625                 630                 635                 640 


Trp Tyr Glu Ile Arg Val Gly Ser Ser Ser Arg Asp Leu Arg Leu Thr 
                645                 650                 655     


Ala Ser Val Glu Val Thr Ser Ala Ala Pro Arg Arg Pro Val Ser Val 
            660                 665                 670         


His Ala Asn Ala Ala Leu Gly Asp Leu Leu Asp Asp Pro Ala Thr Gly 
        675                 680                 685             


Pro Val Leu Arg Glu Leu Leu Lys Glu Lys Leu Ala Asp Ser Pro Leu 
    690                 695                 700                 


Gly Ser Glu Met Asp Ala Asn Pro Met Phe Glu Ala Phe Met Arg Phe 
705                 710                 715                 720 


Thr Pro Ile Gly Arg Val Thr Thr Leu Phe Gly Val Pro Arg Asp Glu 
                725                 730                 735     


Asn Glu Arg Val Leu Ala Lys Leu Arg Ala Ala Gln Glu Glu Gly Gln 
            740                 745                 750         


Pro Glu Glu Gly Arg Gly 
        755             


<210>  384
<211>  757
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:371 and encoded by SEQ ID NO:379

<400>  384

Met Ser Tyr Arg Asp Ile Val Ser Arg Leu Thr Leu Glu Glu Lys Ala 
1               5                   10                  15      


Ser Leu Cys Ser Gly Leu Asn Phe Trp Gln Thr Lys Pro Ile Glu Arg 
            20                  25                  30          


Leu Gly Ile Pro Ser Leu Cys Met Thr Asp Gly Pro His Gly Val Arg 
        35                  40                  45              


Leu Gln Arg Gln Gly Gly Ser Phe Thr Asp Ser Glu Pro Ala Thr Cys 
    50                  55                  60                  


Phe Pro Thr Ala Ala Ala Leu Ala Ser Ser Trp Asp Pro Ala Leu Val 
65                  70                  75                  80  


Glu Arg Ile Gly Gln Ala Leu Gly Asp Glu Cys Arg Ala Leu Gly Val 
                85                  90                  95      


His Val Leu Leu Gly Pro Gly Ala Asn Ile Lys Arg Ser Pro Leu Cys 
            100                 105                 110         


Gly Arg Asn Phe Glu Tyr Phe Ser Glu Asp Pro Leu Leu Ser Ser Glu 
        115                 120                 125             


Met Ala Ala Ala His Ile Arg Gly Val Gln Ser Arg Gly Val Gly Ser 
    130                 135                 140                 


Ser Leu Lys His Phe Ala Ala Asn Asn Gln Glu Tyr Arg Arg Met Thr 
145                 150                 155                 160 


Thr Ser Ala Glu Val Asp Glu Arg Thr Leu Arg Glu Ile Tyr Leu Ala 
                165                 170                 175     


Ser Phe Glu Gly Ala Val Lys Gly Gly Arg Pro Trp Thr Val Met Cys 
            180                 185                 190         


Ala Tyr Asn Arg Leu Asn Gly Thr Tyr Cys Ser Glu His Pro Trp Leu 
        195                 200                 205             


Leu Thr Gln Val Leu Arg Arg Glu Trp Gly Phe Asp Gly Val Val Val 
    210                 215                 220                 


Ser Asp Trp Gly Ala Val Asn Asp Arg Val Gln Gly Leu Ala Ala Gly 
225                 230                 235                 240 


Leu Asp Leu Glu Met Pro Gly Gly Pro Tyr Ala Gln Asp Ala Glu Ile 
                245                 250                 255     


Val Gln Ala Val Arg Asp Gly Arg Leu Asp Glu Ala Val Leu Asp Ala 
            260                 265                 270         


Ala Val Glu Arg Leu Leu Ala Leu Ile Asp Arg Ala Tyr Arg Pro Gln 
        275                 280                 285             


Gly Asp Ser Ala Asp Leu Asp Ala His His Arg Leu Ala Arg Gln Ala 
    290                 295                 300                 


Ala Ala Glu Ser Met Val Leu Leu Lys Asn Asp Gly Ala Val Leu Pro 
305                 310                 315                 320 


Ile Ala Pro Gly Arg Arg Val Ala Val Ile Gly Ala Phe Ala Val Ser 
                325                 330                 335     


Pro Arg Tyr Gln Gly Gly Gly Ser Ser His Val Asn Pro Ala Arg Leu 
            340                 345                 350         


Asp Glu Pro Leu Ala Glu Met Arg Arg Ala Phe Gly Asp Gln Leu Val 
        355                 360                 365             


Leu Tyr Ala Pro Gly Tyr Ala Leu Asp Asp Asp Ala Pro Arg Leu Glu 
    370                 375                 380                 


Leu Ile Glu Glu Ala Val Arg Ala Ala Ala Gln Ala Asp Val Ala Ala 
385                 390                 395                 400 


Ile Phe Ala Gly Leu Pro Glu Ser Trp Glu Ser Glu Gly Tyr Asp Arg 
                405                 410                 415     


Pro His Met Arg Met Pro Asp Ala His Val Ala Leu Ile Glu Ala Val 
            420                 425                 430         


Thr Ser Ala Gln Pro Arg Thr Val Val Val Leu Ser Asn Gly Ala Pro 
        435                 440                 445             


Val Glu Met Pro Trp Ile His Arg Val Pro Ala Val Ile Glu Ala Tyr 
    450                 455                 460                 


Leu Ala Gly Gln Ala Phe Gly Gly Ala Ile Ala Asp Val Leu Ser Gly 
465                 470                 475                 480 


Ala Val Asn Pro Ser Gly Lys Leu Ala Glu Thr Phe Pro Leu Arg Leu 
                485                 490                 495     


Glu His Asn Pro Ser His Pro Tyr Phe Pro Gly Glu Gly Asp Arg Ser 
            500                 505                 510         


Glu Tyr Arg Glu Gly Val Phe Val Gly Tyr Arg Tyr Tyr Asp Thr Lys 
        515                 520                 525             


Glu Met Asp Val Leu Phe Pro Phe Gly His Gly Leu Ser Tyr Thr Thr 
    530                 535                 540                 


Phe Glu Tyr Glu Ala Ile Arg Met Ser Arg Glu Gln Val Arg Asp Asp 
545                 550                 555                 560 


Asp Val Leu Thr Val Gln Val Asp Val Arg Asn Thr Gly Gln Arg Ala 
                565                 570                 575     


Gly Lys Glu Val Val Gln Val Tyr Val Glu Pro Arg Ser Ser Arg Val 
            580                 585                 590         


Val Arg Pro Arg Arg Glu Leu Arg Ala Phe Ala Lys Val Ala Leu Ala 
        595                 600                 605             


Pro Gly Glu Thr Arg Thr Val Glu Phe Gln Leu Gly Lys Arg Ala Phe 
    610                 615                 620                 


Ala Tyr Tyr Asp Val Asp Ala Gly Asp Phe Ala Val Glu Ser Gly Trp 
625                 630                 635                 640 


Tyr Glu Ile Arg Val Gly Ser Ser Ser Arg Asp Leu Arg Leu Thr Ala 
                645                 650                 655     


Ser Val Glu Val Thr Ser Ala Ala Pro Arg Arg Pro Val Ser Val His 
            660                 665                 670         


Ala Asn Ala Ala Leu Gly Asp Leu Leu Asp Asp Pro Ala Thr Gly Pro 
        675                 680                 685             


Val Leu Arg Glu Leu Leu Lys Glu Lys Leu Ala Asp Ser Pro Leu Gly 
    690                 695                 700                 


Ser Glu Met Asp Ala Asn Pro Met Phe Glu Ala Phe Met Arg Phe Thr 
705                 710                 715                 720 


Pro Ile Gly Arg Val Thr Thr Leu Phe Gly Val Pro Arg Asp Glu Asn 
                725                 730                 735     


Glu Arg Val Leu Ala Lys Leu Arg Ala Ala Gln Glu Glu Gly Gln Pro 
            740                 745                 750         


Glu Glu Gly Arg Gly 
        755         


<210>  385
<211>  757
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:371 and encoded by SEQ ID NO:380

<400>  385

Met Ser Tyr Arg Asp Val Val Ser Arg Leu Thr Leu Glu Glu Lys Ala 
1               5                   10                  15      


Ser Leu Cys Ser Gly Leu Asn Phe Trp Gln Thr Lys Pro Ile Glu Arg 
            20                  25                  30          


Leu Gly Ile Pro Ser Leu Cys Met Thr Asp Gly Pro His Gly Val Arg 
        35                  40                  45              


Leu Gln Arg Gln Gly Gly Ser Phe Thr Asp Ser Glu Pro Ala Thr Cys 
    50                  55                  60                  


Phe Pro Thr Ala Ala Ala Leu Ala Ser Ser Trp Asp Pro Ala Leu Val 
65                  70                  75                  80  


Glu Arg Ile Gly Gln Ala Leu Gly Asp Glu Cys Arg Ala Leu Gly Val 
                85                  90                  95      


His Val Leu Leu Gly Pro Gly Ala Asn Ile Lys Arg Ser Pro Leu Cys 
            100                 105                 110         


Gly Arg Asn Phe Glu Tyr Phe Ser Glu Asp Pro Leu Leu Ser Ser Glu 
        115                 120                 125             


Met Ala Ala Ala His Ile Arg Gly Val Gln Ser Arg Gly Val Gly Ser 
    130                 135                 140                 


Ser Leu Lys His Phe Ala Ala Asn Asn Gln Glu Tyr Arg Arg Met Thr 
145                 150                 155                 160 


Thr Ser Ala Glu Val Asp Glu Arg Thr Leu Arg Glu Ile Tyr Leu Ala 
                165                 170                 175     


Ser Phe Glu Gly Ala Val Lys Gly Gly Arg Pro Trp Thr Val Met Cys 
            180                 185                 190         


Ala Tyr Asn Arg Leu Asn Gly Thr Tyr Cys Ser Glu His Pro Trp Leu 
        195                 200                 205             


Leu Thr Gln Val Leu Arg Arg Glu Trp Gly Phe Asp Gly Val Val Val 
    210                 215                 220                 


Ser Asp Trp Gly Ala Val Asn Asp Arg Val Gln Gly Leu Ala Ala Gly 
225                 230                 235                 240 


Leu Asp Leu Glu Met Pro Gly Gly Pro Tyr Ala Gln Asp Ala Glu Ile 
                245                 250                 255     


Val Gln Ala Val Arg Asp Gly Arg Leu Asp Glu Ala Val Leu Asp Ala 
            260                 265                 270         


Ala Val Glu Arg Leu Leu Ala Leu Ile Asp Arg Ala Tyr Arg Pro Gln 
        275                 280                 285             


Gly Asp Ser Ala Asp Leu Asp Ala His His Arg Leu Ala Arg Gln Ala 
    290                 295                 300                 


Ala Ala Glu Ser Met Val Leu Leu Lys Asn Asp Gly Ala Val Leu Pro 
305                 310                 315                 320 


Ile Ala Pro Gly Arg Arg Val Ala Val Ile Gly Ala Phe Ala Val Ser 
                325                 330                 335     


Pro Arg Tyr Gln Gly Gly Gly Ser Ser His Val Asn Pro Ala Arg Leu 
            340                 345                 350         


Asp Glu Pro Leu Ala Glu Met Arg Arg Ala Phe Gly Asp Gln Leu Val 
        355                 360                 365             


Leu Tyr Ala Pro Gly Tyr Ala Leu Asp Asp Asp Ala Pro Arg Leu Glu 
    370                 375                 380                 


Leu Ile Glu Glu Ala Val Arg Ala Ala Ala Gln Ala Asp Val Ala Ala 
385                 390                 395                 400 


Ile Phe Ala Gly Leu Pro Glu Ser Trp Glu Ser Glu Gly Tyr Asp Arg 
                405                 410                 415     


Pro His Met Arg Met Pro Asp Ala His Val Ala Leu Ile Glu Ala Val 
            420                 425                 430         


Thr Ser Ala Gln Pro Arg Thr Val Val Val Leu Ser Asn Gly Ala Pro 
        435                 440                 445             


Val Glu Met Pro Trp Ile His Arg Val Pro Ala Val Ile Glu Ala Tyr 
    450                 455                 460                 


Leu Ala Gly Gln Ala Phe Gly Gly Ala Ile Ala Asp Val Leu Ser Gly 
465                 470                 475                 480 


Ala Val Asn Pro Ser Gly Lys Leu Ala Glu Thr Phe Pro Leu Arg Leu 
                485                 490                 495     


Glu His Asn Pro Ser His Pro Tyr Phe Pro Gly Glu Gly Asp Arg Ser 
            500                 505                 510         


Glu Tyr Arg Glu Gly Val Phe Val Gly Tyr Arg Tyr Tyr Asp Thr Lys 
        515                 520                 525             


Glu Met Asp Val Leu Phe Pro Phe Gly His Gly Leu Ser Tyr Thr Thr 
    530                 535                 540                 


Phe Glu Tyr Glu Ala Ile Arg Met Ser Arg Glu Gln Val Arg Asp Asp 
545                 550                 555                 560 


Asp Val Leu Thr Val Gln Val Asp Val Arg Asn Thr Gly Gln Arg Ala 
                565                 570                 575     


Gly Lys Glu Val Val Gln Val Tyr Val Glu Pro Arg Ser Ser Arg Val 
            580                 585                 590         


Val Arg Pro Arg Arg Glu Leu Arg Ala Phe Ala Lys Val Ala Leu Ala 
        595                 600                 605             


Pro Gly Glu Thr Arg Thr Val Glu Phe Gln Leu Gly Lys Arg Ala Phe 
    610                 615                 620                 


Ala Tyr Tyr Asp Val Asp Ala Gly Asp Phe Ala Val Glu Ser Gly Trp 
625                 630                 635                 640 


Tyr Glu Ile Arg Val Gly Ser Ser Ser Arg Asp Leu Arg Leu Thr Ala 
                645                 650                 655     


Ser Val Glu Val Thr Ser Ala Ala Pro Arg Arg Pro Val Ser Val His 
            660                 665                 670         


Ala Asn Ala Ala Leu Gly Asp Leu Leu Asp Asp Pro Ala Thr Gly Pro 
        675                 680                 685             


Val Leu Arg Glu Leu Leu Lys Glu Lys Leu Ala Asp Ser Pro Leu Gly 
    690                 695                 700                 


Ser Glu Met Asp Ala Asn Pro Met Phe Glu Ala Phe Met Arg Phe Thr 
705                 710                 715                 720 


Pro Ile Gly Arg Val Thr Thr Leu Phe Gly Val Pro Arg Asp Glu Asn 
                725                 730                 735     


Glu Arg Val Leu Ala Lys Leu Arg Ala Ala Gln Glu Glu Gly Gln Pro 
            740                 745                 750         


Glu Glu Gly Arg Gly 
        755         


<210>  386
<211>  757
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:371 and encoded by SEQ ID NO:381

<400>  386

Met Ser Tyr Arg Asp Leu Leu Ser Arg Leu Thr Leu Glu Glu Lys Ala 
1               5                   10                  15      


Ser Leu Cys Ser Gly Leu Asn Phe Trp Gln Thr Lys Pro Ile Glu Arg 
            20                  25                  30          


Leu Gly Ile Pro Ser Leu Cys Met Thr Asp Gly Pro His Gly Val Arg 
        35                  40                  45              


Leu Gln Arg Gln Gly Gly Ser Phe Thr Asp Ser Glu Pro Ala Thr Cys 
    50                  55                  60                  


Phe Pro Thr Ala Ala Ala Leu Ala Ser Ser Trp Asp Pro Ala Leu Val 
65                  70                  75                  80  


Glu Arg Ile Gly Gln Ala Leu Gly Asp Glu Cys Arg Ala Leu Gly Val 
                85                  90                  95      


His Val Leu Leu Gly Pro Gly Ala Asn Ile Lys Arg Ser Pro Leu Cys 
            100                 105                 110         


Gly Arg Asn Phe Glu Tyr Phe Ser Glu Asp Pro Leu Leu Ser Ser Glu 
        115                 120                 125             


Met Ala Ala Ala His Ile Arg Gly Val Gln Ser Arg Gly Val Gly Ser 
    130                 135                 140                 


Ser Leu Lys His Phe Ala Ala Asn Asn Gln Glu Tyr Arg Arg Met Thr 
145                 150                 155                 160 


Thr Ser Ala Glu Val Asp Glu Arg Thr Leu Arg Glu Ile Tyr Leu Ala 
                165                 170                 175     


Ser Phe Glu Gly Ala Val Lys Gly Gly Arg Pro Trp Thr Val Met Cys 
            180                 185                 190         


Ala Tyr Asn Arg Leu Asn Gly Thr Tyr Cys Ser Glu His Pro Trp Leu 
        195                 200                 205             


Leu Thr Gln Val Leu Arg Arg Glu Trp Gly Phe Asp Gly Val Val Val 
    210                 215                 220                 


Ser Asp Trp Gly Ala Val Asn Asp Arg Val Gln Gly Leu Ala Ala Gly 
225                 230                 235                 240 


Leu Asp Leu Glu Met Pro Gly Gly Pro Tyr Ala Gln Asp Ala Glu Ile 
                245                 250                 255     


Val Gln Ala Val Arg Asp Gly Arg Leu Asp Glu Ala Val Leu Asp Ala 
            260                 265                 270         


Ala Val Glu Arg Leu Leu Ala Leu Ile Asp Arg Ala Tyr Arg Pro Gln 
        275                 280                 285             


Gly Asp Ser Ala Asp Leu Asp Ala His His Arg Leu Ala Arg Gln Ala 
    290                 295                 300                 


Ala Ala Glu Ser Met Val Leu Leu Lys Asn Asp Gly Ala Val Leu Pro 
305                 310                 315                 320 


Ile Ala Pro Gly Arg Arg Val Ala Val Ile Gly Ala Phe Ala Val Ser 
                325                 330                 335     


Pro Arg Tyr Gln Gly Gly Gly Ser Ser His Val Asn Pro Ala Arg Leu 
            340                 345                 350         


Asp Glu Pro Leu Ala Glu Met Arg Arg Ala Phe Gly Asp Gln Leu Val 
        355                 360                 365             


Leu Tyr Ala Pro Gly Tyr Ala Leu Asp Asp Asp Ala Pro Arg Leu Glu 
    370                 375                 380                 


Leu Ile Glu Glu Ala Val Arg Ala Ala Ala Gln Ala Asp Val Ala Ala 
385                 390                 395                 400 


Ile Phe Ala Gly Leu Pro Glu Ser Trp Glu Ser Glu Gly Tyr Asp Arg 
                405                 410                 415     


Pro His Met Arg Met Pro Asp Ala His Val Ala Leu Ile Glu Ala Val 
            420                 425                 430         


Thr Ser Ala Gln Pro Arg Thr Val Val Val Leu Ser Asn Gly Ala Pro 
        435                 440                 445             


Val Glu Met Pro Trp Ile His Arg Val Pro Ala Val Ile Glu Ala Tyr 
    450                 455                 460                 


Leu Ala Gly Gln Ala Phe Gly Gly Ala Ile Ala Asp Val Leu Ser Gly 
465                 470                 475                 480 


Ala Val Asn Pro Ser Gly Lys Leu Ala Glu Thr Phe Pro Leu Arg Leu 
                485                 490                 495     


Glu His Asn Pro Ser His Pro Tyr Phe Pro Gly Glu Gly Asp Arg Ser 
            500                 505                 510         


Glu Tyr Arg Glu Gly Val Phe Val Gly Tyr Arg Tyr Tyr Asp Thr Lys 
        515                 520                 525             


Glu Met Asp Val Leu Phe Pro Phe Gly His Gly Leu Ser Tyr Thr Thr 
    530                 535                 540                 


Phe Glu Tyr Glu Ala Ile Arg Met Ser Arg Glu Gln Val Arg Asp Asp 
545                 550                 555                 560 


Asp Val Leu Thr Val Gln Val Asp Val Arg Asn Thr Gly Gln Arg Ala 
                565                 570                 575     


Gly Lys Glu Val Val Gln Val Tyr Val Glu Pro Arg Ser Ser Arg Val 
            580                 585                 590         


Val Arg Pro Arg Arg Glu Leu Arg Ala Phe Ala Lys Val Ala Leu Ala 
        595                 600                 605             


Pro Gly Glu Thr Arg Thr Val Glu Phe Gln Leu Gly Lys Arg Ala Phe 
    610                 615                 620                 


Ala Tyr Tyr Asp Val Asp Ala Gly Asp Phe Ala Val Glu Ser Gly Trp 
625                 630                 635                 640 


Tyr Glu Ile Arg Val Gly Ser Ser Ser Arg Asp Leu Arg Leu Thr Ala 
                645                 650                 655     


Ser Val Glu Val Thr Ser Ala Ala Pro Arg Arg Pro Val Ser Val His 
            660                 665                 670         


Ala Asn Ala Ala Leu Gly Asp Leu Leu Asp Asp Pro Ala Thr Gly Pro 
        675                 680                 685             


Val Leu Arg Glu Leu Leu Lys Glu Lys Leu Ala Asp Ser Pro Leu Gly 
    690                 695                 700                 


Ser Glu Met Asp Ala Asn Pro Met Phe Glu Ala Phe Met Arg Phe Thr 
705                 710                 715                 720 


Pro Ile Gly Arg Val Thr Thr Leu Phe Gly Val Pro Arg Asp Glu Asn 
                725                 730                 735     


Glu Arg Val Leu Ala Lys Leu Arg Ala Ala Gln Glu Glu Gly Gln Pro 
            740                 745                 750         


Glu Glu Gly Arg Gly 
        755         


<210>  387
<211>  1023
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  387
ttgaccaccc gcttgtggag gcatcctaat ccgcgtgtga tgcggatgga gggatgcctg     60

atgaagccaa ggcagttggc tcttggtcta tgcgccggtg cgtgtgcctg gatgttcggc    120

gccgggctct ggatacgcgc ggacgccccg cctcaaccca cgcccgcccc gtcggagcgc    180

gtgtgggagg aggtgagccg cgcgtgggcg aatcctccca tcgatgcgcg gcgggatcgc    240

gtgtggcaca acatcccggg cctctccggc tttgccctcg atacggcggc gagcgagcgc    300

gagacggcgc gattccacga cggcgcgctg cacctcgtgt ggcgaacggt gccgccgagg    360

gtacggcttc gcgatctccc gcccgacgtg atctatcgcg gcccggcgga ggaaaaatcc    420

gtcgccctca tggtgaacgt gtcctggggc gaggcgtacg tgccgaggat gcttcaaatc    480

ttgcgggacg cgcatgtgaa ggcgacgttc tttgtcgacg gcgcctgggc gaagaagttt    540

cccgatctcg tccgcgccat ggcgcaagac gggcacgccg tggaatccca cggatccggg    600

catccggact ttcgccggct gaacgacgcg aagctcgccg cgcagatcga cgagaccaat    660

cgagttctcg cggccatcac gggcagagcg ccgcggctca tcgcgccgcc cgccggatcg    720

tacgatgctc gcctcgcgcc gctcgcaaag tcgcgcggca tgtacgccat cctgtggact    780

gcggacacgg tcgactggaa aaacccgccc cccgccgcca ttgtcgagcg ggtgcagcgg    840

ggcgccgagc caggtgcgct cgtgctcatg cacccgacgg cttcgaccgt cgaggcgctc    900

ccggtgatga tccgctggct tgaggcgcgc gggtaccgga tgaagacggt ggaagacgtg    960

atcgacgagc ggccggcagt cacacctccc accatcctgg cgcgggagac catccgctta   1020

tga                                                                 1023


<210>  388
<211>  340
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  388

Met Thr Thr Arg Leu Trp Arg His Pro Asn Pro Arg Val Met Arg Met 
1               5                   10                  15      


Glu Gly Cys Leu Met Lys Pro Arg Gln Leu Ala Leu Gly Leu Cys Ala 
            20                  25                  30          


Gly Ala Cys Ala Trp Met Phe Gly Ala Gly Leu Trp Ile Arg Ala Asp 
        35                  40                  45              


Ala Pro Pro Gln Pro Thr Pro Ala Pro Ser Glu Arg Val Trp Glu Glu 
    50                  55                  60                  


Val Ser Arg Ala Trp Ala Asn Pro Pro Ile Asp Ala Arg Arg Asp Arg 
65                  70                  75                  80  


Val Trp His Asn Ile Pro Gly Leu Ser Gly Phe Ala Leu Asp Thr Ala 
                85                  90                  95      


Ala Ser Glu Arg Glu Thr Ala Arg Phe His Asp Gly Ala Leu His Leu 
            100                 105                 110         


Val Trp Arg Thr Val Pro Pro Arg Val Arg Leu Arg Asp Leu Pro Pro 
        115                 120                 125             


Asp Val Ile Tyr Arg Gly Pro Ala Glu Glu Lys Ser Val Ala Leu Met 
    130                 135                 140                 


Val Asn Val Ser Trp Gly Glu Ala Tyr Val Pro Arg Met Leu Gln Ile 
145                 150                 155                 160 


Leu Arg Asp Ala His Val Lys Ala Thr Phe Phe Val Asp Gly Ala Trp 
                165                 170                 175     


Ala Lys Lys Phe Pro Asp Leu Val Arg Ala Met Ala Gln Asp Gly His 
            180                 185                 190         


Ala Val Glu Ser His Gly Ser Gly His Pro Asp Phe Arg Arg Leu Asn 
        195                 200                 205             


Asp Ala Lys Leu Ala Ala Gln Ile Asp Glu Thr Asn Arg Val Leu Ala 
    210                 215                 220                 


Ala Ile Thr Gly Arg Ala Pro Arg Leu Ile Ala Pro Pro Ala Gly Ser 
225                 230                 235                 240 


Tyr Asp Ala Arg Leu Ala Pro Leu Ala Lys Ser Arg Gly Met Tyr Ala 
                245                 250                 255     


Ile Leu Trp Thr Ala Asp Thr Val Asp Trp Lys Asn Pro Pro Pro Ala 
            260                 265                 270         


Ala Ile Val Glu Arg Val Gln Arg Gly Ala Glu Pro Gly Ala Leu Val 
        275                 280                 285             


Leu Met His Pro Thr Ala Ser Thr Val Glu Ala Leu Pro Val Met Ile 
    290                 295                 300                 


Arg Trp Leu Glu Ala Arg Gly Tyr Arg Met Lys Thr Val Glu Asp Val 
305                 310                 315                 320 


Ile Asp Glu Arg Pro Ala Val Thr Pro Pro Thr Ile Leu Ala Arg Glu 
                325                 330                 335     


Thr Ile Arg Leu 
            340 


<210>  389
<211>  323
<212>  PRT
<213>  Bacillus halodurans

<400>  389

Met Lys Lys Ile Leu Ile His Gly Cys Val Phe Ala Ile Ile Leu Leu 
1               5                   10                  15      


Met Thr Tyr Gly Ala Val Gln Asn Pro Phe Ser Ser Gln Tyr Ile Gly 
            20                  25                  30          


Gln Leu Lys Glu Glu Ala Leu Pro Val Ala Lys Met Thr Asp Ser Leu 
        35                  40                  45              


Tyr Glu Glu Ile Lys Asp Arg Ala Pro Glu Tyr Glu Gln Pro Ala Ile 
    50                  55                  60                  


Asp Ala Lys Ile Asp Arg Val Trp Lys Ala Ile Pro Gly Tyr Asn Gly 
65                  70                  75                  80  


Leu Glu Val Asp Val Glu Ser Ser Tyr Asn Arg Met Lys Gln Glu Gly 
                85                  90                  95      


Arg Phe Asp Glu Arg Tyr Leu Val Phe Arg Glu Thr Lys Pro Ser Val 
            100                 105                 110         


His Leu Asp Asp Leu Pro Pro Ser Pro Val Phe Arg Gly Asn Pro Glu 
        115                 120                 125             


Lys Pro Met Val Thr Leu Leu Val Asn Val Ala Trp Gly Asn Glu His 
    130                 135                 140                 


Leu Pro Thr Met Leu Lys Thr Met Asn Lys Tyr Asp Val Lys Ser Thr 
145                 150                 155                 160 


Phe Phe Leu Asp Gly Ser Trp Val Lys Lys His Pro Gln Leu Ala Thr 
                165                 170                 175     


Met Ile Val Glu Glu Gly His Glu Ile Gly Asn His Ala Tyr Ser His 
            180                 185                 190         


Pro Asp Met Gln Arg Leu Thr Arg Glu Arg Met Asp Glu Glu Ile Val 
        195                 200                 205             


Gln Thr Asn Glu Val Ile Lys Ala Thr Ile Glu Val Thr Pro Lys Trp 
    210                 215                 220                 


Phe Ala Pro Pro Ser Gly Ser Tyr Asn Asp Leu Val Val Gln Arg Ala 
225                 230                 235                 240 


Ala Glu His Gly Met Arg Thr Ile Met Trp Ser Val Asp Thr Ile Asp 
                245                 250                 255     


Trp Arg Asn Pro Asp Pro Asn Glu Met Val Asp Arg Val Leu Ser Lys 
            260                 265                 270         


Val His Pro Gly Ala Met Ile Leu Met His Pro Thr Glu Ser Ser Ala 
        275                 280                 285             


Ala Gly Leu Glu Asn Leu Ile Arg Gly Ile Gln Asp Arg Gly Leu His 
    290                 295                 300                 


Ile Gly Thr Val Ser Asp Leu Met Asp Glu Ser Arg Ile Asn Ala Gly 
305                 310                 315                 320 


Val Thr Pro 
            


<210>  390
<211>  335
<212>  PRT
<213>  Bacillus coagulans 

<400>  390

Met Asn Lys Ala Lys Arg Leu Ile Ala Leu Gly Leu Ile Ala Ile Leu 
1               5                   10                  15      


Ala Leu Leu Leu Ala Gly Asn Pro Leu Ser Thr Arg Tyr Leu Gln Glu 
            20                  25                  30          


Arg Ala Ala Phe Ser Thr Lys Glu Asn Glu Leu Gln Glu Lys Ile Glu 
        35                  40                  45              


Gln Ala Ala Glu Arg Phe Tyr Arg Pro Pro Glu Asn Ala Lys Ile Asp 
    50                  55                  60                  


Arg Val Trp Lys Ala Ile Pro Gly Tyr Asn Gly Val Glu Val Asp Lys 
65                  70                  75                  80  


Lys Ala Ser Tyr Ser Lys Met Lys Gln Asp Gly Arg Tyr Asp Glu Arg 
                85                  90                  95      


Lys Leu Val Phe Lys Gln Ile Pro Pro Ala Val His Leu Lys Asp Leu 
            100                 105                 110         


Asp Pro Ala Pro Val Tyr Thr Gly Asn Pro Asp Lys Pro Met Val Ala 
        115                 120                 125             


Phe Leu Ile Asn Val Ala Trp Gly Asn Glu Tyr Leu Pro Asp Met Leu 
    130                 135                 140                 


Lys Thr Leu Lys Lys His His Leu His Ala Thr Phe Phe Leu Glu Gly 
145                 150                 155                 160 


Arg Trp Ala Lys Glu Asn Pro Glu Leu Ala Arg Met Ile Val Ser Gly 
                165                 170                 175     


Gly His Glu Thr Gly Asn His Ser Tyr Thr His Pro Asp Phe Ser Thr 
            180                 185                 190         


Leu Pro Glu Ser Lys Ile Lys Ser Gln Leu Val Lys Thr Asn Arg Val 
        195                 200                 205             


Leu Glu Ala Ile Thr Glu Glu Lys Val Lys Trp Phe Ala Pro Pro Ser 
    210                 215                 220                 


Gly Ser Tyr Arg Asp Glu Ala Val Ser Ile Ala Lys Ser Met Gly Met 
225                 230                 235                 240 


Glu Thr Ile Met Trp Thr Val Asp Thr Val Asp Trp Gln Asn Pro Ser 
                245                 250                 255     


Pro Glu Thr Ile Val Glu Arg Val Thr Ala Lys Ala Gln Gly Gly Ser 
            260                 265                 270         


Leu Ile Leu Met His Pro Thr Ala Ser Thr Ala Lys Ala Leu Glu Pro 
        275                 280                 285             


Leu Ile Ala Arg Leu Glu Lys Lys Asn Leu Gln Val Gly Thr Val Ser 
    290                 295                 300                 


Lys Leu Leu Asp Glu Glu Arg Ile Ile Lys Asn Glu Asp Gly Thr Phe 
305                 310                 315                 320 


Leu Asn Ser Glu Lys Asp Pro Ala Asp Thr Lys Asp Gly Thr Glu 
                325                 330                 335 


<210>  391
<211>  238
<212>  PRT
<213>  Thermoanaerobacter ethanolicus

<400>  391

Met Lys Ile Phe Tyr Ile Lys Tyr Pro Lys Lys Ser Phe Trp Ile Ile 
1               5                   10                  15      


Phe Ser Leu Ala Ile Leu Leu Leu Ile Phe Leu Ile Tyr Ile Ile Thr 
            20                  25                  30          


Arg Ser Val Ser Val Phe Asn Ser Asn Glu Pro Ile Tyr Lys Gly Asp 
        35                  40                  45              


Thr Lys Glu Lys Lys Ile Ala Phe Ala Cys Asn Val Ala Trp Gly Asp 
    50                  55                  60                  


Glu Tyr Ile Pro Lys Met Leu Asp Ile Phe Lys Asp Asn Asn Ile His 
65                  70                  75                  80  


Ile Thr Phe Phe Phe Glu Gly Lys Trp Ala Glu Lys Asn Pro Asp Val 
                85                  90                  95      


Val Lys Asp Ile Tyr Gln Lys Gly His Glu Ile Gly Ser His Gly Tyr 
            100                 105                 110         


Thr His Val Lys Tyr Thr Asn Leu Ser Arg Gln Gln Tyr Glu Glu Asp 
        115                 120                 125             


Ile Lys Lys Ser Gly Glu Ile Leu Glu Lys Ile Thr Gly Thr Lys Pro 
    130                 135                 140                 


Thr Leu Phe Ala Pro Pro Tyr Gly Asp Phe Asn Asp Glu Val Val Lys 
145                 150                 155                 160 


Val Ala Glu Gln Leu Gly Tyr Lys Val Ile Leu Trp Ser Leu Asp Thr 
                165                 170                 175     


Ile Asp Trp Asn Asn Pro Ser Pro Gln Thr Ile Val Asp Arg Val Met 
            180                 185                 190         


Thr Lys Tyr His Asn Gly Ala Ile Val Leu Met His Pro Thr Gln Asn 
        195                 200                 205             


Thr Val Glu Ala Leu Pro Gln Ile Ile Lys Gln Leu Lys Glu Lys Gly 
    210                 215                 220                 


Tyr Lys Ile Thr Lys Val Ser Glu Val Ile Val Asp Asn Asn 
225                 230                 235             


<210>  392
<211>  317
<212>  PRT
<213>  Bacillus NRRL B-14911

<400>  392

Met Lys Lys Leu Ala Gly Met Leu Leu Ile Gly Ala Phe Ser Leu Met 
1               5                   10                  15      


Leu Val Asn Asn Pro Phe Thr Asp Leu Tyr Val Ser Gln Leu Lys Met 
            20                  25                  30          


Asp Ser Leu Ala Val Thr Ala Glu Ser Asp Ser Leu Leu Gln Arg Ile 
        35                  40                  45              


Glu Lys Glu Ser Glu Asn Tyr Tyr Ile Ala Pro Gln Asp Ala Arg Ile 
    50                  55                  60                  


Asp Pro Val Trp Lys Ala Ile Pro Gly Tyr Asn Gly Val Lys Val Asp 
65                  70                  75                  80  


Val Glu Ala Ser Tyr Lys Lys Met Lys Gly Glu Lys Lys Phe Asp Pro 
                85                  90                  95      


Asp Lys Leu Val Leu Glu Gln Ile Glu Pro Glu Lys Lys Leu Gly Asp 
            100                 105                 110         


Leu Pro Pro Ala Pro Ile Tyr Lys Gly Asn Pro Asp Lys Pro Met Val 
        115                 120                 125             


Ser Phe Ile Ile Asn Val Ala Trp Gly Asn Glu Tyr Leu Ser Gly Met 
    130                 135                 140                 


Leu Ala Thr Leu Lys Lys His Lys Val Thr Ala Thr Phe Phe Leu Glu 
145                 150                 155                 160 


Gly Arg Trp Val Gln Gln Asn Pro Glu Leu Ala Lys Met Ile Thr Glu 
                165                 170                 175     


Ala Gly His Glu Ala Gly Asn His Ser Phe Thr His Pro Asp Met Lys 
            180                 185                 190         


Thr Ile Ser Ser Ala Arg Ile Arg Glu Glu Ile Glu Lys Thr Asn Gln 
        195                 200                 205             


Val Ile Lys Ala Thr Thr Gly Gln Glu Val Thr Trp Phe Ala Pro Pro 
    210                 215                 220                 


Ser Gly Ser Tyr Arg Asp Glu Thr Val Arg Ile Ala Ala Glu Lys Lys 
225                 230                 235                 240 


Leu Lys Thr Val Met Trp Ser Leu Asp Thr Val Asp Trp Arg Lys Pro 
                245                 250                 255     


Ser Pro Glu Glu Leu Leu Asn Arg Val Val Pro Lys Val His Asn Gly 
            260                 265                 270         


Ala Ile Ile Leu Met His Pro Thr Asp Ser Thr Ala Lys Ser Leu Asp 
        275                 280                 285             


Ser Met Ile Thr Gln Ile Lys Gly Lys Asp Phe Glu Ile Ala Ser Val 
    290                 295                 300                 


Ser Arg Leu Leu Ser Glu Glu Arg Ile Met Asp Lys Lys 
305                 310                 315         


<210>  393
<211>  319
<212>  PRT
<213>  Bacillus subtilis

<400>  393

Met Tyr Lys Lys Phe Val Pro Phe Ala Val Phe Leu Phe Leu Phe Phe 
1               5                   10                  15      


Val Ser Phe Glu Met Met Glu Asn Pro His Ala Leu Asp Tyr Ile Gly 
            20                  25                  30          


Ala Met Lys Lys Asp Thr Val Thr Val Thr Ala Ser Lys Asp Pro Leu 
        35                  40                  45              


Tyr Glu Glu Leu Leu Gln Lys Ala Pro Glu Tyr Glu Val Lys Pro Gln 
    50                  55                  60                  


Asn Ala Arg Ile Asp Lys Val Trp Lys Ser Ile Pro Gly Tyr Asn Gly 
65                  70                  75                  80  


Leu Lys Val Asn Ile Glu Gln Ser Tyr Lys Lys Met Lys Gln His Gly 
                85                  90                  95      


Lys Phe Arg Glu Lys Asp Leu Val Tyr Ser Gln Val Lys Pro Ser Val 
            100                 105                 110         


His Leu Glu Ser Leu Gln Pro Glu Pro Ile Tyr Lys Gly Asn Pro Asp 
        115                 120                 125             


Lys Pro Met Val Ala Phe Leu Ile Asn Val Ala Trp Gly Asn Glu Tyr 
    130                 135                 140                 


Leu Glu Lys Met Leu Pro Ile Leu Gln Lys His Gln Val Lys Ala Thr 
145                 150                 155                 160 


Phe Phe Leu Glu Gly Asn Trp Val Arg Asn Asn Val Gln Leu Ala Lys 
                165                 170                 175     


Lys Ile Ala Lys Asp Gly His Glu Ile Gly Asn His Ser Tyr Asn His 
            180                 185                 190         


Pro Asp Met Ser Lys Leu Thr Thr Gly Arg Ile Ser Glu Gln Leu Asp 
        195                 200                 205             


Lys Thr Asn Glu Gln Ile Glu Gln Thr Ile Gly Val Lys Pro Lys Trp 
    210                 215                 220                 


Phe Ala Pro Pro Ser Gly Ser Phe Arg Lys Ala Val Ile Asp Ile Ala 
225                 230                 235                 240 


Ala Glu Lys Gln Met Gly Thr Val Met Trp Thr Val Asp Thr Ile Asp 
                245                 250                 255     


Trp Gln Lys Pro Ala Pro Ser Val Leu Gln Thr Arg Val Leu Ser Lys 
            260                 265                 270         


Ile His Asn Gly Ala Met Ile Leu Met His Pro Thr Asp Pro Thr Ala 
        275                 280                 285             


Glu Ser Leu Glu Ala Leu Ile Thr Gln Ile Lys Asp Lys Gly Tyr Ala 
    290                 295                 300                 


Leu Gly Thr Val Thr Glu Leu Met Asp Glu Thr Arg Leu Leu Lys 
305                 310                 315                 


<210>  394
<211>  1023
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 387

<400>  394
ttgaccacca agttgtggag gcatcctaat ccgcgtgtga tgcggatgga gggatgcctg     60

atgaagccaa ggcagttggc tcttggtcta tgcgccggtg cgtgtgcctg gatgttcggc    120

gccgggctct ggatacgcgc ggacgccccg cctcaaccca cgcccgcccc gtcggagcgc    180

gtgtgggagg aggtgagccg cgcgtgggcg aatcctccca tcgatgcgcg gcgggatcgc    240

gtgtggcaca acatcccggg cctctccggc tttgccctcg atacggcggc gagcgagcgc    300

gagacggcgc gattccacga cggcgcgctg cacctcgtgt ggcgaacggt gccgccgagg    360

gtacggcttc gcgatctccc gcccgacgtg atctatcgcg gcccggcgga ggaaaaatcc    420

gtcgccctca tggtgaacgt gtcctggggc gaggcgtacg tgccgaggat gcttcaaatc    480

ttgcgggacg cgcatgtgaa ggcgacgttc tttgtcgacg gcgcctgggc gaagaagttt    540

cccgatctcg tccgcgccat ggcgcaagac gggcacgccg tggaatccca cggatccggg    600

catccggact ttcgccggct gaacgacgcg aagctcgccg cgcagatcga cgagaccaat    660

cgagttctcg cggccatcac gggcagagcg ccgcggctca tcgcgccgcc cgccggatcg    720

tacgatgctc gcctcgcgcc gctcgcaaag tcgcgcggca tgtacgccat cctgtggact    780

gcggacacgg tcgactggaa aaacccgccc cccgccgcca ttgtcgagcg ggtgcagcgg    840

ggcgccgagc caggtgcgct cgtgctcatg cacccgacgg cttcgaccgt cgaggcgctc    900

ccggtgatga tccgctggct tgaggcgcgc gggtaccgga tgaagacggt ggaagacgtg    960

atcgacgagc ggccggcagt cacacctccc accatcctgg cgcgggagac catccgctta   1020

tga                                                                 1023


<210>  395
<211>  1023
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 387

<400>  395
ttgaccaccc gcatatggag gcatcctaat ccgcgtgtga tgcggatgga gggatgcctg     60

atgaagccaa ggcagttggc tcttggtcta tgcgccggtg cgtgtgcctg gatgttcggc    120

gccgggctct ggatacgcgc ggacgccccg cctcaaccca cgcccgcccc gtcggagcgc    180

gtgtgggagg aggtgagccg cgcgtgggcg aatcctccca tcgatgcgcg gcgggatcgc    240

gtgtggcaca acatcccggg cctctccggc tttgccctcg atacggcggc gagcgagcgc    300

gagacggcgc gattccacga cggcgcgctg cacctcgtgt ggcgaacggt gccgccgagg    360

gtacggcttc gcgatctccc gcccgacgtg atctatcgcg gcccggcgga ggaaaaatcc    420

gtcgccctca tggtgaacgt gtcctggggc gaggcgtacg tgccgaggat gcttcaaatc    480

ttgcgggacg cgcatgtgaa ggcgacgttc tttgtcgacg gcgcctgggc gaagaagttt    540

cccgatctcg tccgcgccat ggcgcaagac gggcacgccg tggaatccca cggatccggg    600

catccggact ttcgccggct gaacgacgcg aagctcgccg cgcagatcga cgagaccaat    660

cgagttctcg cggccatcac gggcagagcg ccgcggctca tcgcgccgcc cgccggatcg    720

tacgatgctc gcctcgcgcc gctcgcaaag tcgcgcggca tgtacgccat cctgtggact    780

gcggacacgg tcgactggaa aaacccgccc cccgccgcca ttgtcgagcg ggtgcagcgg    840

ggcgccgagc caggtgcgct cgtgctcatg cacccgacgg cttcgaccgt cgaggcgctc    900

ccggtgatga tccgctggct tgaggcgcgc gggtaccgga tgaagacggt ggaagacgtg    960

atcgacgagc ggccggcagt cacacctccc accatcctgg cgcgggagac catccgctta   1020

tga                                                                 1023


<210>  396
<211>  1023
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 387

<400>  396
ttgaccaccc gcgtgtggag gcatcctaat ccgcgtgtga tgcggatgga gggatgcctg     60

atgaagccaa ggcagttggc tcttggtcta tgcgccggtg cgtgtgcctg gatgttcggc    120

gccgggctct ggatacgcgc ggacgccccg cctcaaccca cgcccgcccc gtcggagcgc    180

gtgtgggagg aggtgagccg cgcgtgggcg aatcctccca tcgatgcgcg gcgggatcgc    240

gtgtggcaca acatcccggg cctctccggc tttgccctcg atacggcggc gagcgagcgc    300

gagacggcgc gattccacga cggcgcgctg cacctcgtgt ggcgaacggt gccgccgagg    360

gtacggcttc gcgatctccc gcccgacgtg atctatcgcg gcccggcgga ggaaaaatcc    420

gtcgccctca tggtgaacgt gtcctggggc gaggcgtacg tgccgaggat gcttcaaatc    480

ttgcgggacg cgcatgtgaa ggcgacgttc tttgtcgacg gcgcctgggc gaagaagttt    540

cccgatctcg tccgcgccat ggcgcaagac gggcacgccg tggaatccca cggatccggg    600

catccggact ttcgccggct gaacgacgcg aagctcgccg cgcagatcga cgagaccaat    660

cgagttctcg cggccatcac gggcagagcg ccgcggctca tcgcgccgcc cgccggatcg    720

tacgatgctc gcctcgcgcc gctcgcaaag tcgcgcggca tgtacgccat cctgtggact    780

gcggacacgg tcgactggaa aaacccgccc cccgccgcca ttgtcgagcg ggtgcagcgg    840

ggcgccgagc caggtgcgct cgtgctcatg cacccgacgg cttcgaccgt cgaggcgctc    900

ccggtgatga tccgctggct tgaggcgcgc gggtaccgga tgaagacggt ggaagacgtg    960

atcgacgagc ggccggcagt cacacctccc accatcctgg cgcgggagac catccgctta   1020

tga                                                                 1023


<210>  397
<211>  1023
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 387

<400>  397
ttgaccaccc gcttgtggaa gcatcctaat ccgcgtgtga tgcggatgga gggatgcctg     60

atgaagccaa ggcagttggc tcttggtcta tgcgccggtg cgtgtgcctg gatgttcggc    120

gccgggctct ggatacgcgc ggacgccccg cctcaaccca cgcccgcccc gtcggagcgc    180

gtgtgggagg aggtgagccg cgcgtgggcg aatcctccca tcgatgcgcg gcgggatcgc    240

gtgtggcaca acatcccggg cctctccggc tttgccctcg atacggcggc gagcgagcgc    300

gagacggcgc gattccacga cggcgcgctg cacctcgtgt ggcgaacggt gccgccgagg    360

gtacggcttc gcgatctccc gcccgacgtg atctatcgcg gcccggcgga ggaaaaatcc    420

gtcgccctca tggtgaacgt gtcctggggc gaggcgtacg tgccgaggat gcttcaaatc    480

ttgcgggacg cgcatgtgaa ggcgacgttc tttgtcgacg gcgcctgggc gaagaagttt    540

cccgatctcg tccgcgccat ggcgcaagac gggcacgccg tggaatccca cggatccggg    600

catccggact ttcgccggct gaacgacgcg aagctcgccg cgcagatcga cgagaccaat    660

cgagttctcg cggccatcac gggcagagcg ccgcggctca tcgcgccgcc cgccggatcg    720

tacgatgctc gcctcgcgcc gctcgcaaag tcgcgcggca tgtacgccat cctgtggact    780

gcggacacgg tcgactggaa aaacccgccc cccgccgcca ttgtcgagcg ggtgcagcgg    840

ggcgccgagc caggtgcgct cgtgctcatg cacccgacgg cttcgaccgt cgaggcgctc    900

ccggtgatga tccgctggct tgaggcgcgc gggtaccgga tgaagacggt ggaagacgtg    960

atcgacgagc ggccggcagt cacacctccc accatcctgg cgcgggagac catccgctta   1020

tga                                                                 1023


<210>  398
<211>  1023
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 387

<400>  398
ttgaccaccc gcttgtggag gcatcctcag ccgcgtgtga tgcggatgga gggatgcctg     60

atgaagccaa ggcagttggc tcttggtcta tgcgccggtg cgtgtgcctg gatgttcggc    120

gccgggctct ggatacgcgc ggacgccccg cctcaaccca cgcccgcccc gtcggagcgc    180

gtgtgggagg aggtgagccg cgcgtgggcg aatcctccca tcgatgcgcg gcgggatcgc    240

gtgtggcaca acatcccggg cctctccggc tttgccctcg atacggcggc gagcgagcgc    300

gagacggcgc gattccacga cggcgcgctg cacctcgtgt ggcgaacggt gccgccgagg    360

gtacggcttc gcgatctccc gcccgacgtg atctatcgcg gcccggcgga ggaaaaatcc    420

gtcgccctca tggtgaacgt gtcctggggc gaggcgtacg tgccgaggat gcttcaaatc    480

ttgcgggacg cgcatgtgaa ggcgacgttc tttgtcgacg gcgcctgggc gaagaagttt    540

cccgatctcg tccgcgccat ggcgcaagac gggcacgccg tggaatccca cggatccggg    600

catccggact ttcgccggct gaacgacgcg aagctcgccg cgcagatcga cgagaccaat    660

cgagttctcg cggccatcac gggcagagcg ccgcggctca tcgcgccgcc cgccggatcg    720

tacgatgctc gcctcgcgcc gctcgcaaag tcgcgcggca tgtacgccat cctgtggact    780

gcggacacgg tcgactggaa aaacccgccc cccgccgcca ttgtcgagcg ggtgcagcgg    840

ggcgccgagc caggtgcgct cgtgctcatg cacccgacgg cttcgaccgt cgaggcgctc    900

ccggtgatga tccgctggct tgaggcgcgc gggtaccgga tgaagacggt ggaagacgtg    960

atcgacgagc ggccggcagt cacacctccc accatcctgg cgcgggagac catccgctta   1020

tga                                                                 1023


<210>  399
<211>  340
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:388 and encoded by SEQ ID NO:394

<400>  399

Met Thr Thr Lys Leu Trp Arg His Pro Asn Pro Arg Val Met Arg Met 
1               5                   10                  15      


Glu Gly Cys Leu Met Lys Pro Arg Gln Leu Ala Leu Gly Leu Cys Ala 
            20                  25                  30          


Gly Ala Cys Ala Trp Met Phe Gly Ala Gly Leu Trp Ile Arg Ala Asp 
        35                  40                  45              


Ala Pro Pro Gln Pro Thr Pro Ala Pro Ser Glu Arg Val Trp Glu Glu 
    50                  55                  60                  


Val Ser Arg Ala Trp Ala Asn Pro Pro Ile Asp Ala Arg Arg Asp Arg 
65                  70                  75                  80  


Val Trp His Asn Ile Pro Gly Leu Ser Gly Phe Ala Leu Asp Thr Ala 
                85                  90                  95      


Ala Ser Glu Arg Glu Thr Ala Arg Phe His Asp Gly Ala Leu His Leu 
            100                 105                 110         


Val Trp Arg Thr Val Pro Pro Arg Val Arg Leu Arg Asp Leu Pro Pro 
        115                 120                 125             


Asp Val Ile Tyr Arg Gly Pro Ala Glu Glu Lys Ser Val Ala Leu Met 
    130                 135                 140                 


Val Asn Val Ser Trp Gly Glu Ala Tyr Val Pro Arg Met Leu Gln Ile 
145                 150                 155                 160 


Leu Arg Asp Ala His Val Lys Ala Thr Phe Phe Val Asp Gly Ala Trp 
                165                 170                 175     


Ala Lys Lys Phe Pro Asp Leu Val Arg Ala Met Ala Gln Asp Gly His 
            180                 185                 190         


Ala Val Glu Ser His Gly Ser Gly His Pro Asp Phe Arg Arg Leu Asn 
        195                 200                 205             


Asp Ala Lys Leu Ala Ala Gln Ile Asp Glu Thr Asn Arg Val Leu Ala 
    210                 215                 220                 


Ala Ile Thr Gly Arg Ala Pro Arg Leu Ile Ala Pro Pro Ala Gly Ser 
225                 230                 235                 240 


Tyr Asp Ala Arg Leu Ala Pro Leu Ala Lys Ser Arg Gly Met Tyr Ala 
                245                 250                 255     


Ile Leu Trp Thr Ala Asp Thr Val Asp Trp Lys Asn Pro Pro Pro Ala 
            260                 265                 270         


Ala Ile Val Glu Arg Val Gln Arg Gly Ala Glu Pro Gly Ala Leu Val 
        275                 280                 285             


Leu Met His Pro Thr Ala Ser Thr Val Glu Ala Leu Pro Val Met Ile 
    290                 295                 300                 


Arg Trp Leu Glu Ala Arg Gly Tyr Arg Met Lys Thr Val Glu Asp Val 
305                 310                 315                 320 


Ile Asp Glu Arg Pro Ala Val Thr Pro Pro Thr Ile Leu Ala Arg Glu 
                325                 330                 335     


Thr Ile Arg Leu 
            340 


<210>  400
<211>  340
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:388 and encoded by SEQ ID NO:395

<400>  400

Met Thr Thr Arg Ile Trp Arg His Pro Asn Pro Arg Val Met Arg Met 
1               5                   10                  15      


Glu Gly Cys Leu Met Lys Pro Arg Gln Leu Ala Leu Gly Leu Cys Ala 
            20                  25                  30          


Gly Ala Cys Ala Trp Met Phe Gly Ala Gly Leu Trp Ile Arg Ala Asp 
        35                  40                  45              


Ala Pro Pro Gln Pro Thr Pro Ala Pro Ser Glu Arg Val Trp Glu Glu 
    50                  55                  60                  


Val Ser Arg Ala Trp Ala Asn Pro Pro Ile Asp Ala Arg Arg Asp Arg 
65                  70                  75                  80  


Val Trp His Asn Ile Pro Gly Leu Ser Gly Phe Ala Leu Asp Thr Ala 
                85                  90                  95      


Ala Ser Glu Arg Glu Thr Ala Arg Phe His Asp Gly Ala Leu His Leu 
            100                 105                 110         


Val Trp Arg Thr Val Pro Pro Arg Val Arg Leu Arg Asp Leu Pro Pro 
        115                 120                 125             


Asp Val Ile Tyr Arg Gly Pro Ala Glu Glu Lys Ser Val Ala Leu Met 
    130                 135                 140                 


Val Asn Val Ser Trp Gly Glu Ala Tyr Val Pro Arg Met Leu Gln Ile 
145                 150                 155                 160 


Leu Arg Asp Ala His Val Lys Ala Thr Phe Phe Val Asp Gly Ala Trp 
                165                 170                 175     


Ala Lys Lys Phe Pro Asp Leu Val Arg Ala Met Ala Gln Asp Gly His 
            180                 185                 190         


Ala Val Glu Ser His Gly Ser Gly His Pro Asp Phe Arg Arg Leu Asn 
        195                 200                 205             


Asp Ala Lys Leu Ala Ala Gln Ile Asp Glu Thr Asn Arg Val Leu Ala 
    210                 215                 220                 


Ala Ile Thr Gly Arg Ala Pro Arg Leu Ile Ala Pro Pro Ala Gly Ser 
225                 230                 235                 240 


Tyr Asp Ala Arg Leu Ala Pro Leu Ala Lys Ser Arg Gly Met Tyr Ala 
                245                 250                 255     


Ile Leu Trp Thr Ala Asp Thr Val Asp Trp Lys Asn Pro Pro Pro Ala 
            260                 265                 270         


Ala Ile Val Glu Arg Val Gln Arg Gly Ala Glu Pro Gly Ala Leu Val 
        275                 280                 285             


Leu Met His Pro Thr Ala Ser Thr Val Glu Ala Leu Pro Val Met Ile 
    290                 295                 300                 


Arg Trp Leu Glu Ala Arg Gly Tyr Arg Met Lys Thr Val Glu Asp Val 
305                 310                 315                 320 


Ile Asp Glu Arg Pro Ala Val Thr Pro Pro Thr Ile Leu Ala Arg Glu 
                325                 330                 335     


Thr Ile Arg Leu 
            340 


<210>  401
<211>  340
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:388 and encoded by SEQ ID NO:396

<400>  401

Met Thr Thr Arg Val Trp Arg His Pro Asn Pro Arg Val Met Arg Met 
1               5                   10                  15      


Glu Gly Cys Leu Met Lys Pro Arg Gln Leu Ala Leu Gly Leu Cys Ala 
            20                  25                  30          


Gly Ala Cys Ala Trp Met Phe Gly Ala Gly Leu Trp Ile Arg Ala Asp 
        35                  40                  45              


Ala Pro Pro Gln Pro Thr Pro Ala Pro Ser Glu Arg Val Trp Glu Glu 
    50                  55                  60                  


Val Ser Arg Ala Trp Ala Asn Pro Pro Ile Asp Ala Arg Arg Asp Arg 
65                  70                  75                  80  


Val Trp His Asn Ile Pro Gly Leu Ser Gly Phe Ala Leu Asp Thr Ala 
                85                  90                  95      


Ala Ser Glu Arg Glu Thr Ala Arg Phe His Asp Gly Ala Leu His Leu 
            100                 105                 110         


Val Trp Arg Thr Val Pro Pro Arg Val Arg Leu Arg Asp Leu Pro Pro 
        115                 120                 125             


Asp Val Ile Tyr Arg Gly Pro Ala Glu Glu Lys Ser Val Ala Leu Met 
    130                 135                 140                 


Val Asn Val Ser Trp Gly Glu Ala Tyr Val Pro Arg Met Leu Gln Ile 
145                 150                 155                 160 


Leu Arg Asp Ala His Val Lys Ala Thr Phe Phe Val Asp Gly Ala Trp 
                165                 170                 175     


Ala Lys Lys Phe Pro Asp Leu Val Arg Ala Met Ala Gln Asp Gly His 
            180                 185                 190         


Ala Val Glu Ser His Gly Ser Gly His Pro Asp Phe Arg Arg Leu Asn 
        195                 200                 205             


Asp Ala Lys Leu Ala Ala Gln Ile Asp Glu Thr Asn Arg Val Leu Ala 
    210                 215                 220                 


Ala Ile Thr Gly Arg Ala Pro Arg Leu Ile Ala Pro Pro Ala Gly Ser 
225                 230                 235                 240 


Tyr Asp Ala Arg Leu Ala Pro Leu Ala Lys Ser Arg Gly Met Tyr Ala 
                245                 250                 255     


Ile Leu Trp Thr Ala Asp Thr Val Asp Trp Lys Asn Pro Pro Pro Ala 
            260                 265                 270         


Ala Ile Val Glu Arg Val Gln Arg Gly Ala Glu Pro Gly Ala Leu Val 
        275                 280                 285             


Leu Met His Pro Thr Ala Ser Thr Val Glu Ala Leu Pro Val Met Ile 
    290                 295                 300                 


Arg Trp Leu Glu Ala Arg Gly Tyr Arg Met Lys Thr Val Glu Asp Val 
305                 310                 315                 320 


Ile Asp Glu Arg Pro Ala Val Thr Pro Pro Thr Ile Leu Ala Arg Glu 
                325                 330                 335     


Thr Ile Arg Leu 
            340 


<210>  402
<211>  340
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:388 and encoded by SEQ ID NO:397

<400>  402

Met Thr Thr Arg Leu Trp Lys His Pro Asn Pro Arg Val Met Arg Met 
1               5                   10                  15      


Glu Gly Cys Leu Met Lys Pro Arg Gln Leu Ala Leu Gly Leu Cys Ala 
            20                  25                  30          


Gly Ala Cys Ala Trp Met Phe Gly Ala Gly Leu Trp Ile Arg Ala Asp 
        35                  40                  45              


Ala Pro Pro Gln Pro Thr Pro Ala Pro Ser Glu Arg Val Trp Glu Glu 
    50                  55                  60                  


Val Ser Arg Ala Trp Ala Asn Pro Pro Ile Asp Ala Arg Arg Asp Arg 
65                  70                  75                  80  


Val Trp His Asn Ile Pro Gly Leu Ser Gly Phe Ala Leu Asp Thr Ala 
                85                  90                  95      


Ala Ser Glu Arg Glu Thr Ala Arg Phe His Asp Gly Ala Leu His Leu 
            100                 105                 110         


Val Trp Arg Thr Val Pro Pro Arg Val Arg Leu Arg Asp Leu Pro Pro 
        115                 120                 125             


Asp Val Ile Tyr Arg Gly Pro Ala Glu Glu Lys Ser Val Ala Leu Met 
    130                 135                 140                 


Val Asn Val Ser Trp Gly Glu Ala Tyr Val Pro Arg Met Leu Gln Ile 
145                 150                 155                 160 


Leu Arg Asp Ala His Val Lys Ala Thr Phe Phe Val Asp Gly Ala Trp 
                165                 170                 175     


Ala Lys Lys Phe Pro Asp Leu Val Arg Ala Met Ala Gln Asp Gly His 
            180                 185                 190         


Ala Val Glu Ser His Gly Ser Gly His Pro Asp Phe Arg Arg Leu Asn 
        195                 200                 205             


Asp Ala Lys Leu Ala Ala Gln Ile Asp Glu Thr Asn Arg Val Leu Ala 
    210                 215                 220                 


Ala Ile Thr Gly Arg Ala Pro Arg Leu Ile Ala Pro Pro Ala Gly Ser 
225                 230                 235                 240 


Tyr Asp Ala Arg Leu Ala Pro Leu Ala Lys Ser Arg Gly Met Tyr Ala 
                245                 250                 255     


Ile Leu Trp Thr Ala Asp Thr Val Asp Trp Lys Asn Pro Pro Pro Ala 
            260                 265                 270         


Ala Ile Val Glu Arg Val Gln Arg Gly Ala Glu Pro Gly Ala Leu Val 
        275                 280                 285             


Leu Met His Pro Thr Ala Ser Thr Val Glu Ala Leu Pro Val Met Ile 
    290                 295                 300                 


Arg Trp Leu Glu Ala Arg Gly Tyr Arg Met Lys Thr Val Glu Asp Val 
305                 310                 315                 320 


Ile Asp Glu Arg Pro Ala Val Thr Pro Pro Thr Ile Leu Ala Arg Glu 
                325                 330                 335     


Thr Ile Arg Leu 
            340 


<210>  403
<211>  340
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:388 and encoded by SEQ ID NO:398

<400>  403

Met Thr Thr Arg Leu Trp Arg His Pro Gln Pro Arg Val Met Arg Met 
1               5                   10                  15      


Glu Gly Cys Leu Met Lys Pro Arg Gln Leu Ala Leu Gly Leu Cys Ala 
            20                  25                  30          


Gly Ala Cys Ala Trp Met Phe Gly Ala Gly Leu Trp Ile Arg Ala Asp 
        35                  40                  45              


Ala Pro Pro Gln Pro Thr Pro Ala Pro Ser Glu Arg Val Trp Glu Glu 
    50                  55                  60                  


Val Ser Arg Ala Trp Ala Asn Pro Pro Ile Asp Ala Arg Arg Asp Arg 
65                  70                  75                  80  


Val Trp His Asn Ile Pro Gly Leu Ser Gly Phe Ala Leu Asp Thr Ala 
                85                  90                  95      


Ala Ser Glu Arg Glu Thr Ala Arg Phe His Asp Gly Ala Leu His Leu 
            100                 105                 110         


Val Trp Arg Thr Val Pro Pro Arg Val Arg Leu Arg Asp Leu Pro Pro 
        115                 120                 125             


Asp Val Ile Tyr Arg Gly Pro Ala Glu Glu Lys Ser Val Ala Leu Met 
    130                 135                 140                 


Val Asn Val Ser Trp Gly Glu Ala Tyr Val Pro Arg Met Leu Gln Ile 
145                 150                 155                 160 


Leu Arg Asp Ala His Val Lys Ala Thr Phe Phe Val Asp Gly Ala Trp 
                165                 170                 175     


Ala Lys Lys Phe Pro Asp Leu Val Arg Ala Met Ala Gln Asp Gly His 
            180                 185                 190         


Ala Val Glu Ser His Gly Ser Gly His Pro Asp Phe Arg Arg Leu Asn 
        195                 200                 205             


Asp Ala Lys Leu Ala Ala Gln Ile Asp Glu Thr Asn Arg Val Leu Ala 
    210                 215                 220                 


Ala Ile Thr Gly Arg Ala Pro Arg Leu Ile Ala Pro Pro Ala Gly Ser 
225                 230                 235                 240 


Tyr Asp Ala Arg Leu Ala Pro Leu Ala Lys Ser Arg Gly Met Tyr Ala 
                245                 250                 255     


Ile Leu Trp Thr Ala Asp Thr Val Asp Trp Lys Asn Pro Pro Pro Ala 
            260                 265                 270         


Ala Ile Val Glu Arg Val Gln Arg Gly Ala Glu Pro Gly Ala Leu Val 
        275                 280                 285             


Leu Met His Pro Thr Ala Ser Thr Val Glu Ala Leu Pro Val Met Ile 
    290                 295                 300                 


Arg Trp Leu Glu Ala Arg Gly Tyr Arg Met Lys Thr Val Glu Asp Val 
305                 310                 315                 320 


Ile Asp Glu Arg Pro Ala Val Thr Pro Pro Thr Ile Leu Ala Arg Glu 
                325                 330                 335     


Thr Ile Arg Leu 
            340 


<210>  404
<211>  852
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  404
atgtttgacg caagttatat ccaccgaggt gatttatgcg gaagggaggg acggcatgtg     60

tcgcgccgaa tggggtcagc cctgatcggt ttgctcgctg catcctcgtt cgtaacctat    120

ggcacgccta tcgtgcacgc aaccccgtca gggcaggcga aggtcgtcta tctgaccttc    180

gatgacggcc caagtcaacg atatacgccc aaactcctgg acatcctgcg caaccaacac    240

atttccgcga cgtttttcgt ggtgggatat cggtgcgagc agttcccaga tatcgttcgt    300

cgaattcaac gggaaggcca cgagattggg aaccacggtt tttcccatct tgaccccaaa    360

aagcacgcgc tggaagagtt catcctcgat atccggaaga ccgacacggc cgtggtgaag    420

gcctgcggaa cgaagcccct gtactacagg cccccgtatg gctccatcga cgcaagcgag    480

atcgactgtg tgcacaaact cggccacccc attgcgctgt ggaccgtcga ctcgatggac    540

tggaaggcca aatcggcgaa tgcgattgtc agccaagtcg aacgccacgc gcagcccggc    600

tccatcatct tgtttcacga cgggatcagc tcgagccgat ataccatcga ggcgatgcca    660

cgcatcattc gcgactttcg ccgcgatgga tacacattca agacgctccc catccgcgat    720

tcactgcgga tagaggcgtt cgtgccgaaa accgacgacg acgccatcct tccacgtgat    780

acccacgacg tccagcgcaa acaccgacca tcggtcggca cgcgctgcat aggccgtcag    840

agccgcgact aa                                                        852


<210>  405
<211>  283
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  405

Met Phe Asp Ala Ser Tyr Ile His Arg Gly Asp Leu Cys Gly Arg Glu 
1               5                   10                  15      


Gly Arg His Val Ser Arg Arg Met Gly Ser Ala Leu Ile Gly Leu Leu 
            20                  25                  30          


Ala Ala Ser Ser Phe Val Thr Tyr Gly Thr Pro Ile Val His Ala Thr 
        35                  40                  45              


Pro Ser Gly Gln Ala Lys Val Val Tyr Leu Thr Phe Asp Asp Gly Pro 
    50                  55                  60                  


Ser Gln Arg Tyr Thr Pro Lys Leu Leu Asp Ile Leu Arg Asn Gln His 
65                  70                  75                  80  


Ile Ser Ala Thr Phe Phe Val Val Gly Tyr Arg Cys Glu Gln Phe Pro 
                85                  90                  95      


Asp Ile Val Arg Arg Ile Gln Arg Glu Gly His Glu Ile Gly Asn His 
            100                 105                 110         


Gly Phe Ser His Leu Asp Pro Lys Lys His Ala Leu Glu Glu Phe Ile 
        115                 120                 125             


Leu Asp Ile Arg Lys Thr Asp Thr Ala Val Val Lys Ala Cys Gly Thr 
    130                 135                 140                 


Lys Pro Leu Tyr Tyr Arg Pro Pro Tyr Gly Ser Ile Asp Ala Ser Glu 
145                 150                 155                 160 


Ile Asp Cys Val His Lys Leu Gly His Pro Ile Ala Leu Trp Thr Val 
                165                 170                 175     


Asp Ser Met Asp Trp Lys Ala Lys Ser Ala Asn Ala Ile Val Ser Gln 
            180                 185                 190         


Val Glu Arg His Ala Gln Pro Gly Ser Ile Ile Leu Phe His Asp Gly 
        195                 200                 205             


Ile Ser Ser Ser Arg Tyr Thr Ile Glu Ala Met Pro Arg Ile Ile Arg 
    210                 215                 220                 


Asp Phe Arg Arg Asp Gly Tyr Thr Phe Lys Thr Leu Pro Ile Arg Asp 
225                 230                 235                 240 


Ser Leu Arg Ile Glu Ala Phe Val Pro Lys Thr Asp Asp Asp Ala Ile 
                245                 250                 255     


Leu Pro Arg Asp Thr His Asp Val Gln Arg Lys His Arg Pro Ser Val 
            260                 265                 270         


Gly Thr Arg Cys Ile Gly Arg Gln Ser Arg Asp 
        275                 280             


<210>  406
<211>  219
<212>  PRT
<213>  Bradyrhizobium elkanii 

<400>  406

Met Asn Glu Leu Ile Pro Leu Ser Ala Val Arg Cys Asn Tyr Gly Asp 
1               5                   10                  15      


Val Ser Gly Ser Arg Ser Val Tyr Leu Thr Phe Asp Asp Gly Pro Asn 
            20                  25                  30          


Pro Phe Cys Thr Pro Leu Val Leu Asp Val Leu Thr Gln His Arg Val 
        35                  40                  45              


Pro Ala Thr Phe Phe Val Ile Gly Thr Tyr Ala Ala Asp Gln Pro Glu 
    50                  55                  60                  


Leu Ile Arg Arg Met Ile Ala Glu Gly His Glu Val Ala Asn His Thr 
65                  70                  75                  80  


Met Thr His Pro Asp Leu Ser Arg Cys Glu Ala Ala Glu Ile His Asp 
                85                  90                  95      


Glu Val Leu Thr Ala Ser Arg Ala Ile Arg Leu Ala Cys Pro Gln Ala 
            100                 105                 110         


Leu Pro Arg His Met Arg Ala Pro Tyr Gly Ile Trp Thr Glu Asp Val 
        115                 120                 125             


Leu Ala Thr Ser Ala Lys Ala Gly Leu Ala Ala Val His Trp Ser Val 
    130                 135                 140                 


Asp Pro Arg Asp Trp Ser Arg Pro Gly Val Asp Ser Ile Val Lys Ser 
145                 150                 155                 160 


Val Leu Ala Ala Val Arg Pro Gly Ala Ile Val Leu Leu His Asp Gly 
                165                 170                 175     


Tyr Pro Pro Gly Glu Glu Ala Ser Cys Ile Asp Ser Thr Ser Arg Glu 
            180                 185                 190         


Gln Thr Val Arg Ala Leu Ala Tyr Leu Ile Pro Ala Leu Gln Leu Arg 
        195                 200                 205             


Gly Phe Glu Ile His Pro Leu Pro Gln Leu His 
    210                 215                 


<210>  407
<211>  219
<212>  PRT
<213>  Mesorhizobium loti

<400>  407

Met Arg Arg Leu Asp Asp Arg Trp Glu Val Gln Ser Glu Cys Ala Asp 
1               5                   10                  15      


Gly Thr Gly Arg Arg Ser Val Tyr Leu Thr Phe Asp Asp Gly Pro Asn 
            20                  25                  30          


Pro Cys Phe Thr Pro Gln Ile Leu Asp Val Leu Ala Gln Asn Arg Val 
        35                  40                  45              


Pro Ala Thr Phe Phe Val Ile Gly Ala Tyr Ala Ala Glu His Pro Asp 
    50                  55                  60                  


Leu Ile Gln Arg Met Ile Ala Glu Gly His Glu Val Gly Asn His Thr 
65                  70                  75                  80  


Met Ser His Pro Asp Leu Ser Lys Cys Gly Leu Gly Glu Val Gln Arg 
                85                  90                  95      


Glu Val Phe Glu Ala Asn Gln Ala Ile Met Leu Ala Cys Pro Gln Ala 
            100                 105                 110         


Ser Ile Arg Tyr Ile Arg Ala Pro Tyr Gly Ala Trp Ser Glu Glu Val 
        115                 120                 125             


Leu Thr Ala Ser Glu Ile Ala Gly Leu Ala Ala Leu His Trp Ser Ile 
    130                 135                 140                 


Asp Pro Arg Asp Trp Ser Arg Pro Gly Thr Asp Ala Ile Val Asp Ala 
145                 150                 155                 160 


Val Leu Ala Ser Val Arg Pro Gly Ala Ile Val Leu Leu His Asp Gly 
                165                 170                 175     


Cys Pro Pro Asp Glu Ser Thr Arg Ser Thr Gln Ala Ser Leu Arg Asn 
            180                 185                 190         


Gln Thr Val Met Ala Leu Ser Asn Leu Ile Pro Ala Leu Asp Ala Cys 
        195                 200                 205             


Gly Tyr Glu Ile Arg Ser Leu Pro Glu His His 
    210                 215                 


<210>  408
<211>  217
<212>  PRT
<213>  Sinorhizobium meliloti

<400>  408

Met Lys His Leu Asp Tyr Ile His Glu Val Pro Ser Asn Cys Asp Tyr 
1               5                   10                  15      


Gly Thr Glu Asp Arg Ser Ile Tyr Leu Thr Phe Asp Asp Gly Pro Asn 
            20                  25                  30          


Pro His Cys Thr Pro Glu Ile Leu Asp Val Leu Ala Glu Tyr Gly Val 
        35                  40                  45              


Pro Ala Thr Phe Phe Val Ile Gly Thr Tyr Ala Lys Ser Gln Pro Glu 
    50                  55                  60                  


Leu Ile Arg Arg Ile Val Ala Glu Gly His Glu Val Ala Asn His Thr 
65                  70                  75                  80  


Met Thr His Pro Asp Leu Ser Thr Cys Gly Pro His Glu Val Glu Arg 
                85                  90                  95      


Glu Ile Val Glu Ala Ser Glu Ala Ile Ile Ala Ala Cys Pro Gln Ala 
            100                 105                 110         


Ala Val Arg His Ile Arg Ala Pro Tyr Gly Val Trp Ser Glu Glu Ala 
        115                 120                 125             


Leu Thr Arg Ser Ala Ser Ala Gly Leu Thr Ala Ile His Trp Ser Ala 
    130                 135                 140                 


Asp Pro Arg Asp Trp Ser Arg Pro Gly Ala Asn Ala Ile Val Asp Ala 
145                 150                 155                 160 


Val Leu Asp Ser Val Arg Pro Gly Ala Ile Val Leu Leu His Asp Gly 
                165                 170                 175     


Cys Pro Pro Asp Glu Ser Gly Ala Leu Thr Gly Leu Arg Asp Gln Thr 
            180                 185                 190         


Leu Met Ala Leu Ser Arg Ile Val Pro Ala Leu His Glu Arg Gly Phe 
        195                 200                 205             


Ala Ile Arg Pro Leu Pro Pro His His 
    210                 215         


<210>  409
<211>  216
<212>  PRT
<213>  Rhizobium leguminosarum 

<400>  409

Met Lys Arg Pro Ala Tyr Met Ser Glu Val Pro Val Asn His Thr Ser 
1               5                   10                  15      


Gly Gln Glu Ala Arg Cys Val Tyr Leu Thr Phe Asp Asp Gly Pro Asn 
            20                  25                  30          


Pro Phe Cys Thr Pro Gln Ile Leu Asp Val Leu Ala Glu His Arg Val 
        35                  40                  45              


Pro Ala Thr Phe Phe Ala Ile Gly Ser Tyr Val Lys Asp His Pro Glu 
    50                  55                  60                  


Leu Ile Arg Arg Leu Val Ala Glu Gly His Asp Val Ala Asn His Thr 
65                  70                  75                  80  


Met Thr His Pro Asp Leu Ala Thr Cys Asp Pro Lys Asp Val Lys Arg 
                85                  90                  95      


Glu Ile Asp Glu Ala His Gln Ala Ile Val Ser Ala Cys Pro Gln Ala 
            100                 105                 110         


Leu Val Arg His Leu Arg Ala Pro Tyr Gly Val Trp Thr Glu Asp Val 
        115                 120                 125             


Leu Ser Ala Ser Val Arg Ala Gly Leu Gly Ala Val His Trp Ser Ala 
    130                 135                 140                 


Asp Pro Arg Asp Trp Ser Cys Pro Gly Val Asp Val Ile Val Asp Glu 
145                 150                 155                 160 


Val Leu Ala Ala Ala Arg Pro Gly Ala Ile Val Leu Leu His Asp Gly 
                165                 170                 175     


Cys Pro Pro Asp Glu Val Glu Gln Cys Ser Leu Ala Gly Leu Arg Asp 
            180                 185                 190         


Gln Thr Leu Ile Ala Leu Ser Arg Ile Ile Pro Ala Leu His Ser Arg 
        195                 200                 205             


Gly Phe Glu Ile Arg Ser Leu Pro 
    210                 215     


<210>  410
<211>  214
<212>  PRT
<213>  Rhizobium galegae

<400>  410

Met Lys Asn Leu Asn Ile Ile Asp Ser Val Asp Val Asp Ala Gly Ala 
1               5                   10                  15      


Asp Asp Pro Cys Val Tyr Leu Thr Phe Asp Asp Gly Pro Asn Pro Phe 
            20                  25                  30          


Cys Thr Pro His Ile Leu Asp Val Leu Ala Gln His Ala Val Ser Ala 
        35                  40                  45              


Thr Phe Phe Val Ile Gly Ala Asn Ala Glu Val His Pro Gly Leu Val 
    50                  55                  60                  


Gln Arg Ile Val Ser Glu Gly His Gly Val Ala Asn His Thr Met Thr 
65                  70                  75                  80  


His Pro Asp Leu Ala Thr Cys Ser Arg Pro Gln Val Glu Arg Glu Ile 
                85                  90                  95      


Asp Glu Ala Asn Arg Ala Ile Ile Ser Ala Cys Pro Gly Ala Ser Ile 
            100                 105                 110         


Arg His Ile Arg Ala Pro Tyr Gly Lys Trp Thr Glu Glu Ala Leu Val 
        115                 120                 125             


Lys Ser Ala Ser Leu Gly Leu Ala Pro Val His Trp Ser Val Asp Pro 
    130                 135                 140                 


Arg Asp Trp Ser Cys Pro Gly Val Asp Ala Ile Val Asp Arg Val Leu 
145                 150                 155                 160 


Ala Ala Ala Lys Pro Gly Ser Ile Val Leu Leu His Glu Asp Gly Pro 
                165                 170                 175     


Pro Gly Ala Ala Asp Pro Thr Lys Leu Pro Thr Leu Arg Asp Gln Thr 
            180                 185                 190         


Leu Ala Ala Ile Ser Ala Ile Ile Lys Ser Leu Arg Ser Arg Gly Leu 
        195                 200                 205             


Thr Ile Arg Ser Leu Pro 
    210                 


<210>  411
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 404

<400>  411
atgtttgaag caagttatat ccaccgaggt gatttatgcg gaagggaggg acggcatgtg     60

tcgcgccgaa tggggtcagc cctgatcggt ttgctcgctg catcctcgtt cgtaacctat    120

ggcacgccta tcgtgcacgc aaccccgtca gggcaggcga aggtcgtcta tctgaccttc    180

gatgacggcc caagtcaacg atatacgccc aaactcctgg acatcctgcg caaccaacac    240

atttccgcga cgtttttcgt ggtgggatat cggtgcgagc agttcccaga tatcgttcgt    300

cgaattcaac gggaaggcca cgagattggg aaccacggtt tttcccatct tgaccccaaa    360

aagcacgcgc tggaagagtt catcctcgat atccggaaga ccgacacggc cgtggtgaag    420

gcctgcggaa cgaagcccct gtactacagg cccccgtatg gctccatcga cgcaagcgag    480

atcgactgtg tgcacaaact cggccacccc attgcgctgt ggaccgtcga ctcgatggac    540

tggaaggcca aatcggcgaa tgcgattgtc agccaagtcg aacgccacgc gcagcccggc    600

tccatcatct tgtttcacga cgggatcagc tcgagccgat ataccatcga ggcgatgcca    660

cgcatcattc gcgactttcg ccgcgatgga tacacattca agacgctccc catccgcgat    720

tcactgcgga tagaggcgtt cgtgccgaaa accgacgacg acgccatcct tccacgtgat    780

acccacgacg tccagcgcaa acaccgacca tcggtcggca cgcgctgcat aggccgtcag    840

agccgcgact aa                                                        852


<210>  412
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 404

<400>  412
atgtttgacg caagttatct ccaccgaggt gatttatgcg gaagggaggg acggcatgtg     60

tcgcgccgaa tggggtcagc cctgatcggt ttgctcgctg catcctcgtt cgtaacctat    120

ggcacgccta tcgtgcacgc aaccccgtca gggcaggcga aggtcgtcta tctgaccttc    180

gatgacggcc caagtcaacg atatacgccc aaactcctgg acatcctgcg caaccaacac    240

atttccgcga cgtttttcgt ggtgggatat cggtgcgagc agttcccaga tatcgttcgt    300

cgaattcaac gggaaggcca cgagattggg aaccacggtt tttcccatct tgaccccaaa    360

aagcacgcgc tggaagagtt catcctcgat atccggaaga ccgacacggc cgtggtgaag    420

gcctgcggaa cgaagcccct gtactacagg cccccgtatg gctccatcga cgcaagcgag    480

atcgactgtg tgcacaaact cggccacccc attgcgctgt ggaccgtcga ctcgatggac    540

tggaaggcca aatcggcgaa tgcgattgtc agccaagtcg aacgccacgc gcagcccggc    600

tccatcatct tgtttcacga cgggatcagc tcgagccgat ataccatcga ggcgatgcca    660

cgcatcattc gcgactttcg ccgcgatgga tacacattca agacgctccc catccgcgat    720

tcactgcgga tagaggcgtt cgtgccgaaa accgacgacg acgccatcct tccacgtgat    780

acccacgacg tccagcgcaa acaccgacca tcggtcggca cgcgctgcat aggccgtcag    840

agccgcgact aa                                                        852


<210>  413
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 404

<400>  413
atgtttgacg caagttatgt ccaccgaggt gatttatgcg gaagggaggg acggcatgtg     60

tcgcgccgaa tggggtcagc cctgatcggt ttgctcgctg catcctcgtt cgtaacctat    120

ggcacgccta tcgtgcacgc aaccccgtca gggcaggcga aggtcgtcta tctgaccttc    180

gatgacggcc caagtcaacg atatacgccc aaactcctgg acatcctgcg caaccaacac    240

atttccgcga cgtttttcgt ggtgggatat cggtgcgagc agttcccaga tatcgttcgt    300

cgaattcaac gggaaggcca cgagattggg aaccacggtt tttcccatct tgaccccaaa    360

aagcacgcgc tggaagagtt catcctcgat atccggaaga ccgacacggc cgtggtgaag    420

gcctgcggaa cgaagcccct gtactacagg cccccgtatg gctccatcga cgcaagcgag    480

atcgactgtg tgcacaaact cggccacccc attgcgctgt ggaccgtcga ctcgatggac    540

tggaaggcca aatcggcgaa tgcgattgtc agccaagtcg aacgccacgc gcagcccggc    600

tccatcatct tgtttcacga cgggatcagc tcgagccgat ataccatcga ggcgatgcca    660

cgcatcattc gcgactttcg ccgcgatgga tacacattca agacgctccc catccgcgat    720

tcactgcgga tagaggcgtt cgtgccgaaa accgacgacg acgccatcct tccacgtgat    780

acccacgacg tccagcgcaa acaccgacca tcggtcggca cgcgctgcat aggccgtcag    840

agccgcgact aa                                                        852


<210>  414
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 404

<400>  414
atgtttgacg caagttatat ccacaaaggt gatttatgcg gaagggaggg acggcatgtg     60

tcgcgccgaa tggggtcagc cctgatcggt ttgctcgctg catcctcgtt cgtaacctat    120

ggcacgccta tcgtgcacgc aaccccgtca gggcaggcga aggtcgtcta tctgaccttc    180

gatgacggcc caagtcaacg atatacgccc aaactcctgg acatcctgcg caaccaacac    240

atttccgcga cgtttttcgt ggtgggatat cggtgcgagc agttcccaga tatcgttcgt    300

cgaattcaac gggaaggcca cgagattggg aaccacggtt tttcccatct tgaccccaaa    360

aagcacgcgc tggaagagtt catcctcgat atccggaaga ccgacacggc cgtggtgaag    420

gcctgcggaa cgaagcccct gtactacagg cccccgtatg gctccatcga cgcaagcgag    480

atcgactgtg tgcacaaact cggccacccc attgcgctgt ggaccgtcga ctcgatggac    540

tggaaggcca aatcggcgaa tgcgattgtc agccaagtcg aacgccacgc gcagcccggc    600

tccatcatct tgtttcacga cgggatcagc tcgagccgat ataccatcga ggcgatgcca    660

cgcatcattc gcgactttcg ccgcgatgga tacacattca agacgctccc catccgcgat    720

tcactgcgga tagaggcgtt cgtgccgaaa accgacgacg acgccatcct tccacgtgat    780

acccacgacg tccagcgcaa acaccgacca tcggtcggca cgcgctgcat aggccgtcag    840

agccgcgact aa                                                        852


<210>  415
<211>  852
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 404

<400>  415
atgtttgacg caagttatat ccaccgaggt gagttatgcg gaagggaggg acggcatgtg     60

tcgcgccgaa tggggtcagc cctgatcggt ttgctcgctg catcctcgtt cgtaacctat    120

ggcacgccta tcgtgcacgc aaccccgtca gggcaggcga aggtcgtcta tctgaccttc    180

gatgacggcc caagtcaacg atatacgccc aaactcctgg acatcctgcg caaccaacac    240

atttccgcga cgtttttcgt ggtgggatat cggtgcgagc agttcccaga tatcgttcgt    300

cgaattcaac gggaaggcca cgagattggg aaccacggtt tttcccatct tgaccccaaa    360

aagcacgcgc tggaagagtt catcctcgat atccggaaga ccgacacggc cgtggtgaag    420

gcctgcggaa cgaagcccct gtactacagg cccccgtatg gctccatcga cgcaagcgag    480

atcgactgtg tgcacaaact cggccacccc attgcgctgt ggaccgtcga ctcgatggac    540

tggaaggcca aatcggcgaa tgcgattgtc agccaagtcg aacgccacgc gcagcccggc    600

tccatcatct tgtttcacga cgggatcagc tcgagccgat ataccatcga ggcgatgcca    660

cgcatcattc gcgactttcg ccgcgatgga tacacattca agacgctccc catccgcgat    720

tcactgcgga tagaggcgtt cgtgccgaaa accgacgacg acgccatcct tccacgtgat    780

acccacgacg tccagcgcaa acaccgacca tcggtcggca cgcgctgcat aggccgtcag    840

agccgcgact aa                                                        852


<210>  416
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:450 and encoded by SEQ ID NO:411

<400>  416

Met Phe Glu Ala Ser Tyr Ile His Arg Gly Asp Leu Cys Gly Arg Glu 
1               5                   10                  15      


Gly Arg His Val Ser Arg Arg Met Gly Ser Ala Leu Ile Gly Leu Leu 
            20                  25                  30          


Ala Ala Ser Ser Phe Val Thr Tyr Gly Thr Pro Ile Val His Ala Thr 
        35                  40                  45              


Pro Ser Gly Gln Ala Lys Val Val Tyr Leu Thr Phe Asp Asp Gly Pro 
    50                  55                  60                  


Ser Gln Arg Tyr Thr Pro Lys Leu Leu Asp Ile Leu Arg Asn Gln His 
65                  70                  75                  80  


Ile Ser Ala Thr Phe Phe Val Val Gly Tyr Arg Cys Glu Gln Phe Pro 
                85                  90                  95      


Asp Ile Val Arg Arg Ile Gln Arg Glu Gly His Glu Ile Gly Asn His 
            100                 105                 110         


Gly Phe Ser His Leu Asp Pro Lys Lys His Ala Leu Glu Glu Phe Ile 
        115                 120                 125             


Leu Asp Ile Arg Lys Thr Asp Thr Ala Val Val Lys Ala Cys Gly Thr 
    130                 135                 140                 


Lys Pro Leu Tyr Tyr Arg Pro Pro Tyr Gly Ser Ile Asp Ala Ser Glu 
145                 150                 155                 160 


Ile Asp Cys Val His Lys Leu Gly His Pro Ile Ala Leu Trp Thr Val 
                165                 170                 175     


Asp Ser Met Asp Trp Lys Ala Lys Ser Ala Asn Ala Ile Val Ser Gln 
            180                 185                 190         


Val Glu Arg His Ala Gln Pro Gly Ser Ile Ile Leu Phe His Asp Gly 
        195                 200                 205             


Ile Ser Ser Ser Arg Tyr Thr Ile Glu Ala Met Pro Arg Ile Ile Arg 
    210                 215                 220                 


Asp Phe Arg Arg Asp Gly Tyr Thr Phe Lys Thr Leu Pro Ile Arg Asp 
225                 230                 235                 240 


Ser Leu Arg Ile Glu Ala Phe Val Pro Lys Thr Asp Asp Asp Ala Ile 
                245                 250                 255     


Leu Pro Arg Asp Thr His Asp Val Gln Arg Lys His Arg Pro Ser Val 
            260                 265                 270         


Gly Thr Arg Cys Ile Gly Arg Gln Ser Arg Asp 
        275                 280             


<210>  417
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:450 and encoded by SEQ ID NO:412

<400>  417

Met Phe Asp Ala Ser Tyr Leu His Arg Gly Asp Leu Cys Gly Arg Glu 
1               5                   10                  15      


Gly Arg His Val Ser Arg Arg Met Gly Ser Ala Leu Ile Gly Leu Leu 
            20                  25                  30          


Ala Ala Ser Ser Phe Val Thr Tyr Gly Thr Pro Ile Val His Ala Thr 
        35                  40                  45              


Pro Ser Gly Gln Ala Lys Val Val Tyr Leu Thr Phe Asp Asp Gly Pro 
    50                  55                  60                  


Ser Gln Arg Tyr Thr Pro Lys Leu Leu Asp Ile Leu Arg Asn Gln His 
65                  70                  75                  80  


Ile Ser Ala Thr Phe Phe Val Val Gly Tyr Arg Cys Glu Gln Phe Pro 
                85                  90                  95      


Asp Ile Val Arg Arg Ile Gln Arg Glu Gly His Glu Ile Gly Asn His 
            100                 105                 110         


Gly Phe Ser His Leu Asp Pro Lys Lys His Ala Leu Glu Glu Phe Ile 
        115                 120                 125             


Leu Asp Ile Arg Lys Thr Asp Thr Ala Val Val Lys Ala Cys Gly Thr 
    130                 135                 140                 


Lys Pro Leu Tyr Tyr Arg Pro Pro Tyr Gly Ser Ile Asp Ala Ser Glu 
145                 150                 155                 160 


Ile Asp Cys Val His Lys Leu Gly His Pro Ile Ala Leu Trp Thr Val 
                165                 170                 175     


Asp Ser Met Asp Trp Lys Ala Lys Ser Ala Asn Ala Ile Val Ser Gln 
            180                 185                 190         


Val Glu Arg His Ala Gln Pro Gly Ser Ile Ile Leu Phe His Asp Gly 
        195                 200                 205             


Ile Ser Ser Ser Arg Tyr Thr Ile Glu Ala Met Pro Arg Ile Ile Arg 
    210                 215                 220                 


Asp Phe Arg Arg Asp Gly Tyr Thr Phe Lys Thr Leu Pro Ile Arg Asp 
225                 230                 235                 240 


Ser Leu Arg Ile Glu Ala Phe Val Pro Lys Thr Asp Asp Asp Ala Ile 
                245                 250                 255     


Leu Pro Arg Asp Thr His Asp Val Gln Arg Lys His Arg Pro Ser Val 
            260                 265                 270         


Gly Thr Arg Cys Ile Gly Arg Gln Ser Arg Asp 
        275                 280             


<210>  418
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:450 and encoded by SEQ ID NO:413

<400>  418

Met Phe Asp Ala Ser Tyr Val His Arg Gly Asp Leu Cys Gly Arg Glu 
1               5                   10                  15      


Gly Arg His Val Ser Arg Arg Met Gly Ser Ala Leu Ile Gly Leu Leu 
            20                  25                  30          


Ala Ala Ser Ser Phe Val Thr Tyr Gly Thr Pro Ile Val His Ala Thr 
        35                  40                  45              


Pro Ser Gly Gln Ala Lys Val Val Tyr Leu Thr Phe Asp Asp Gly Pro 
    50                  55                  60                  


Ser Gln Arg Tyr Thr Pro Lys Leu Leu Asp Ile Leu Arg Asn Gln His 
65                  70                  75                  80  


Ile Ser Ala Thr Phe Phe Val Val Gly Tyr Arg Cys Glu Gln Phe Pro 
                85                  90                  95      


Asp Ile Val Arg Arg Ile Gln Arg Glu Gly His Glu Ile Gly Asn His 
            100                 105                 110         


Gly Phe Ser His Leu Asp Pro Lys Lys His Ala Leu Glu Glu Phe Ile 
        115                 120                 125             


Leu Asp Ile Arg Lys Thr Asp Thr Ala Val Val Lys Ala Cys Gly Thr 
    130                 135                 140                 


Lys Pro Leu Tyr Tyr Arg Pro Pro Tyr Gly Ser Ile Asp Ala Ser Glu 
145                 150                 155                 160 


Ile Asp Cys Val His Lys Leu Gly His Pro Ile Ala Leu Trp Thr Val 
                165                 170                 175     


Asp Ser Met Asp Trp Lys Ala Lys Ser Ala Asn Ala Ile Val Ser Gln 
            180                 185                 190         


Val Glu Arg His Ala Gln Pro Gly Ser Ile Ile Leu Phe His Asp Gly 
        195                 200                 205             


Ile Ser Ser Ser Arg Tyr Thr Ile Glu Ala Met Pro Arg Ile Ile Arg 
    210                 215                 220                 


Asp Phe Arg Arg Asp Gly Tyr Thr Phe Lys Thr Leu Pro Ile Arg Asp 
225                 230                 235                 240 


Ser Leu Arg Ile Glu Ala Phe Val Pro Lys Thr Asp Asp Asp Ala Ile 
                245                 250                 255     


Leu Pro Arg Asp Thr His Asp Val Gln Arg Lys His Arg Pro Ser Val 
            260                 265                 270         


Gly Thr Arg Cys Ile Gly Arg Gln Ser Arg Asp 
        275                 280             


<210>  419
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:450 and encoded by SEQ ID NO:414

<400>  419

Met Phe Asp Ala Ser Tyr Ile His Lys Gly Asp Leu Cys Gly Arg Glu 
1               5                   10                  15      


Gly Arg His Val Ser Arg Arg Met Gly Ser Ala Leu Ile Gly Leu Leu 
            20                  25                  30          


Ala Ala Ser Ser Phe Val Thr Tyr Gly Thr Pro Ile Val His Ala Thr 
        35                  40                  45              


Pro Ser Gly Gln Ala Lys Val Val Tyr Leu Thr Phe Asp Asp Gly Pro 
    50                  55                  60                  


Ser Gln Arg Tyr Thr Pro Lys Leu Leu Asp Ile Leu Arg Asn Gln His 
65                  70                  75                  80  


Ile Ser Ala Thr Phe Phe Val Val Gly Tyr Arg Cys Glu Gln Phe Pro 
                85                  90                  95      


Asp Ile Val Arg Arg Ile Gln Arg Glu Gly His Glu Ile Gly Asn His 
            100                 105                 110         


Gly Phe Ser His Leu Asp Pro Lys Lys His Ala Leu Glu Glu Phe Ile 
        115                 120                 125             


Leu Asp Ile Arg Lys Thr Asp Thr Ala Val Val Lys Ala Cys Gly Thr 
    130                 135                 140                 


Lys Pro Leu Tyr Tyr Arg Pro Pro Tyr Gly Ser Ile Asp Ala Ser Glu 
145                 150                 155                 160 


Ile Asp Cys Val His Lys Leu Gly His Pro Ile Ala Leu Trp Thr Val 
                165                 170                 175     


Asp Ser Met Asp Trp Lys Ala Lys Ser Ala Asn Ala Ile Val Ser Gln 
            180                 185                 190         


Val Glu Arg His Ala Gln Pro Gly Ser Ile Ile Leu Phe His Asp Gly 
        195                 200                 205             


Ile Ser Ser Ser Arg Tyr Thr Ile Glu Ala Met Pro Arg Ile Ile Arg 
    210                 215                 220                 


Asp Phe Arg Arg Asp Gly Tyr Thr Phe Lys Thr Leu Pro Ile Arg Asp 
225                 230                 235                 240 


Ser Leu Arg Ile Glu Ala Phe Val Pro Lys Thr Asp Asp Asp Ala Ile 
                245                 250                 255     


Leu Pro Arg Asp Thr His Asp Val Gln Arg Lys His Arg Pro Ser Val 
            260                 265                 270         


Gly Thr Arg Cys Ile Gly Arg Gln Ser Arg Asp 
        275                 280             


<210>  420
<211>  283
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:450 and encoded by SEQ ID NO:415

<400>  420

Met Phe Asp Ala Ser Tyr Ile His Arg Gly Glu Leu Cys Gly Arg Glu 
1               5                   10                  15      


Gly Arg His Val Ser Arg Arg Met Gly Ser Ala Leu Ile Gly Leu Leu 
            20                  25                  30          


Ala Ala Ser Ser Phe Val Thr Tyr Gly Thr Pro Ile Val His Ala Thr 
        35                  40                  45              


Pro Ser Gly Gln Ala Lys Val Val Tyr Leu Thr Phe Asp Asp Gly Pro 
    50                  55                  60                  


Ser Gln Arg Tyr Thr Pro Lys Leu Leu Asp Ile Leu Arg Asn Gln His 
65                  70                  75                  80  


Ile Ser Ala Thr Phe Phe Val Val Gly Tyr Arg Cys Glu Gln Phe Pro 
                85                  90                  95      


Asp Ile Val Arg Arg Ile Gln Arg Glu Gly His Glu Ile Gly Asn His 
            100                 105                 110         


Gly Phe Ser His Leu Asp Pro Lys Lys His Ala Leu Glu Glu Phe Ile 
        115                 120                 125             


Leu Asp Ile Arg Lys Thr Asp Thr Ala Val Val Lys Ala Cys Gly Thr 
    130                 135                 140                 


Lys Pro Leu Tyr Tyr Arg Pro Pro Tyr Gly Ser Ile Asp Ala Ser Glu 
145                 150                 155                 160 


Ile Asp Cys Val His Lys Leu Gly His Pro Ile Ala Leu Trp Thr Val 
                165                 170                 175     


Asp Ser Met Asp Trp Lys Ala Lys Ser Ala Asn Ala Ile Val Ser Gln 
            180                 185                 190         


Val Glu Arg His Ala Gln Pro Gly Ser Ile Ile Leu Phe His Asp Gly 
        195                 200                 205             


Ile Ser Ser Ser Arg Tyr Thr Ile Glu Ala Met Pro Arg Ile Ile Arg 
    210                 215                 220                 


Asp Phe Arg Arg Asp Gly Tyr Thr Phe Lys Thr Leu Pro Ile Arg Asp 
225                 230                 235                 240 


Ser Leu Arg Ile Glu Ala Phe Val Pro Lys Thr Asp Asp Asp Ala Ile 
                245                 250                 255     


Leu Pro Arg Asp Thr His Asp Val Gln Arg Lys His Arg Pro Ser Val 
            260                 265                 270         


Gly Thr Arg Cys Ile Gly Arg Gln Ser Arg Asp 
        275                 280             


<210>  421
<211>  1209
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  421
gtgggagtcg ttcatccccg agtcgggcat gcagtacctc atcatctgtg gccacaatcg     60

tcgactggag cgccgcttct ccgcgattca gagcgagcgc gtccgcgtgt tcgggtatac    120

caacgagatc gagaagttca tggcgatggc ggatctcatc gtcacgaagc cgggcgggct    180

gacgctgacg gagtccatcg cgatgcgcct gcccctcctc atctatcggc cgattccagg    240

tcaggaggag gcgaatgcgc ggttcgccga gcaggcgggt gtggcggtgt gcgtgaagtc    300

tccggcggaa gctcaggcgt tcttgctctc ggtgcgcgaa gacccgtcca tcctgagccg    360

catgcgcgag gcgtgcagcg cgatgccgag ctgtggcgcg gcggagcgca tcgcgcaaaa    420

gatcatgctg tatgccacga agaagcttcc gtgccgctcc gtgtcgccgg agtggccgcc    480

cgagcttctt ccgacgtgag agggagcgcc gtgatcgggt ggttggtcgc cgtggtcctc    540

gccgtcctgg tggtgtacgc ggggctgcct ttcgtctgga cgcggggctt ggggcgttcc    600

tgcattcgca gaacgccgaa gcccgggtgc gtggcgctca cctttgacga tggccctcat    660

cccgtgtaca cgccccggct tctgaacgcg ctcagggaag cgggagcgag agccacgttc    720

ttcgtgatcg ccgagcacgc cctccgtcat cccgagattg tcgaacggat gctggcggag    780

gggcacgaag tgcaggtgca tgggtatcgc cattggtttg tgccgctgtt gccccccgga    840

ctcacggcgc gccaatgcgt gggggccagg gacatcttgg cgcagcggtt cggcattgac    900

ccccgggtct accggccgac ctggggagcg tgcaacctgg cgacgctcgt gatgctcagg    960

cgatcgcgca tgtcgatgct gttgtggagc gtcatggtgg gcgactggcg ccggacacct   1020

ccagaggagc tggcgcgccg cattcttgcc aagctcgacg cgcgctcggt gattgtgctc   1080

cacgacagcg atgagtcccc gggcgcagag cgcggtgcgc cggaaagcgt gattgcggcc   1140

atcccggccg tggtcgagga agtgcgcaga cgcggataca cattcgtgct cgcgtcggaa   1200

tgcgagtag                                                           1209


<210>  422
<211>  402
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  422

Met Gly Val Val His Pro Arg Val Gly His Ala Val Pro His His Leu 
1               5                   10                  15      


Trp Pro Gln Ser Ser Thr Gly Ala Pro Leu Leu Arg Asp Ser Glu Arg 
            20                  25                  30          


Ala Arg Pro Arg Val Arg Val Tyr Gln Arg Asp Arg Glu Val His Gly 
        35                  40                  45              


Asp Gly Gly Ser His Arg His Glu Ala Gly Arg Ala Asp Ala Asp Gly 
    50                  55                  60                  


Val His Arg Asp Ala Pro Ala Pro Pro His Leu Ser Ala Asp Ser Arg 
65                  70                  75                  80  


Ser Gly Gly Gly Glu Cys Ala Val Arg Arg Ala Gly Gly Cys Gly Gly 
                85                  90                  95      


Val Arg Glu Val Ser Gly Gly Ser Ser Gly Val Leu Ala Leu Gly Ala 
            100                 105                 110         


Arg Arg Pro Val His Pro Glu Pro His Ala Arg Gly Val Gln Arg Asp 
        115                 120                 125             


Ala Glu Leu Trp Arg Gly Gly Ala His Arg Ala Lys Asp His Ala Val 
    130                 135                 140                 


Cys His Glu Glu Ala Ser Val Pro Leu Arg Val Ala Gly Val Ala Ala 
145                 150                 155                 160 


Arg Ala Ser Ser Asp Val Arg Gly Ser Ala Val Ile Gly Trp Leu Val 
                165                 170                 175     


Ala Val Val Leu Ala Val Leu Val Val Tyr Ala Gly Leu Pro Phe Val 
            180                 185                 190         


Trp Thr Arg Gly Leu Gly Arg Ser Cys Ile Arg Arg Thr Pro Lys Pro 
        195                 200                 205             


Gly Cys Val Ala Leu Thr Phe Asp Asp Gly Pro His Pro Val Tyr Thr 
    210                 215                 220                 


Pro Arg Leu Leu Asn Ala Leu Arg Glu Ala Gly Ala Arg Ala Thr Phe 
225                 230                 235                 240 


Phe Val Ile Ala Glu His Ala Leu Arg His Pro Glu Ile Val Glu Arg 
                245                 250                 255     


Met Leu Ala Glu Gly His Glu Val Gln Val His Gly Tyr Arg His Trp 
            260                 265                 270         


Phe Val Pro Leu Leu Pro Pro Gly Leu Thr Ala Arg Gln Cys Val Gly 
        275                 280                 285             


Ala Arg Asp Ile Leu Ala Gln Arg Phe Gly Ile Asp Pro Arg Val Tyr 
    290                 295                 300                 


Arg Pro Thr Trp Gly Ala Cys Asn Leu Ala Thr Leu Val Met Leu Arg 
305                 310                 315                 320 


Arg Ser Arg Met Ser Met Leu Leu Trp Ser Val Met Val Gly Asp Trp 
                325                 330                 335     


Arg Arg Thr Pro Pro Glu Glu Leu Ala Arg Arg Ile Leu Ala Lys Leu 
            340                 345                 350         


Asp Ala Arg Ser Val Ile Val Leu His Asp Ser Asp Glu Ser Pro Gly 
        355                 360                 365             


Ala Glu Arg Gly Ala Pro Glu Ser Val Ile Ala Ala Ile Pro Ala Val 
    370                 375                 380                 


Val Glu Glu Val Arg Arg Arg Gly Tyr Thr Phe Val Leu Ala Ser Glu 
385                 390                 395                 400 


Cys Glu 
        


<210>  423
<211>  247
<212>  PRT
<213>  Bacillus coagulans

<400>  423

Met Glu Val Ile Ile Trp Val Leu Ile Leu Phe Ile Leu Ile Tyr Ala 
1               5                   10                  15      


Ile Ile Pro Tyr Val Leu Ala Ala Lys Leu Gly Phe Trp Val Cys Trp 
            20                  25                  30          


Lys Gly Lys Lys Asp Ala Glu Ile Ala Leu Thr Phe Asp Asp Gly Pro 
        35                  40                  45              


Asp Pro Val Tyr Thr Pro Val Leu Leu Asp Leu Leu Lys Arg Glu Arg 
    50                  55                  60                  


Ile Lys Ala Thr Phe Phe Leu Val Gly Glu Arg Ala Ala Arg Tyr Pro 
65                  70                  75                  80  


Glu Leu Val Leu Arg Met Ser Arg Glu Gly His Cys Ile Gly Leu His 
                85                  90                  95      


Asn Tyr Lys His Gln Cys Asn Trp Leu Ile Ser Pro Trp Lys Asn Ala 
            100                 105                 110         


Arg Thr Leu Glu Gln Ser Ala Arg Ile Ile Glu Asn Ile Thr Gly Glu 
        115                 120                 125             


Arg Pro Val Phe Tyr Arg Pro Pro Trp Gly Met Met His Leu Leu Asp 
    130                 135                 140                 


Phe Phe Leu His Lys Gln Phe Arg Met Val His Trp Ser Lys Met Phe 
145                 150                 155                 160 


Arg Asp Trp Lys Arg Lys Gly Gly Ser Lys Lys Val Ser Asn Gly Leu 
                165                 170                 175     


Ile Thr Arg Val Glu Ser Gly Asp Val Ile Leu Leu His Asp Cys Gly 
            180                 185                 190         


Val Thr Pro Gly Ala Asp Glu Asp Ala Pro Gln Tyr Thr Ile Glu Gly 
        195                 200                 205             


Leu Arg Val Ala Ile Pro Ala Leu Lys Ala Arg Gly Phe Arg Phe Val 
    210                 215                 220                 


Arg Met Asp Glu Met Phe Asp Lys His Phe Ser Ile Lys Thr Ser His 
225                 230                 235                 240 


Arg Arg Lys Glu Ile Glu Pro 
                245         


<210>  424
<211>  401
<212>  PRT
<213>  Deinococcus radiodurans

<400>  424

Met Lys Arg Gly Val Arg Gly Leu Leu Leu Gly Ala Ala Leu Tyr Ile 
1               5                   10                  15      


Gly Leu Pro Tyr Leu Leu Val Gln Val Gly Asn Leu Gly Leu Val Arg 
            20                  25                  30          


Glu Gly Arg Arg Ala Arg Arg Glu Val Ala Leu Thr Phe Asp Asp Gly 
        35                  40                  45              


Pro Asp Pro Gln Thr Thr Pro Ala Val Leu Ala Ala Leu Arg Glu Ala 
    50                  55                  60                  


Asp Met His Ala Thr Phe Phe Val Ile Ala Gly Lys Ala Gln Ala His 
65                  70                  75                  80  


Pro Asp Leu Ile Arg Gln Met Leu Glu Glu Gly His Glu Val Glu Ala 
                85                  90                  95      


His Ala Asp Lys His Val His Ala Trp Ile Arg Thr Pro Trp Gly Ala 
            100                 105                 110         


Ala Leu Asp Pro Leu Arg Ala Val Arg Ala Val Gly Ala Met Thr Gly 
        115                 120                 125             


Arg Pro Val Arg Phe His Arg Pro Pro His Gly Ala Tyr Thr Leu Ser 
    130                 135                 140                 


Thr Trp Leu Gly Gln Arg Leu Ala Gly Val Arg Gly Ala His Trp Ser 
145                 150                 155                 160 


Ile Glu Gly Cys Asp Trp His Pro Glu Ser Ile Pro Asp Thr Val Arg 
                165                 170                 175     


Glu Arg Leu Ala Ala Leu Leu Val Pro Gly Ala Val Ile Val Leu His 
            180                 185                 190         


Asp Ala Gly Pro Gly Ala Arg Val Thr Val Pro Leu Leu Pro Ser Leu 
        195                 200                 205             


Leu Ala Asp Leu Lys Ala Arg Gly Tyr Arg Ser Val Thr Leu Ala Glu 
    210                 215                 220                 


Leu Gly Gly Ala Ala Pro Gln Asp Trp Pro Gly Leu Lys Arg Arg Gly 
225                 230                 235                 240 


Phe Leu Ala Leu Asp Ala Val Phe Asp Arg Leu Gly His Ile His Phe 
                245                 250                 255     


Ala Gly Gly Arg Ala Asp Asn Leu Phe Arg Ile Ala Arg Val Pro Phe 
            260                 265                 270         


Pro Leu Glu Gly Ala Arg Leu Ala Asp Gly Thr Pro Ile Pro His Gly 
        275                 280                 285             


Ala Pro Ala Leu Glu Phe His Val Asn Asn Pro Ile Leu Val Asp Leu 
    290                 295                 300                 


Gly Pro Arg Ala Ser Val Arg Gln Ala Arg Arg Glu Asp Phe Arg Val 
305                 310                 315                 320 


Val Ala Arg Glu Leu Gln Thr Arg Pro Glu Tyr Ala Asp Val Gly Tyr 
                325                 330                 335     


Val Phe Cys Leu Ser Ala Val Ser Pro Leu Leu Gly Leu Leu Gly Phe 
            340                 345                 350         


Glu Asn His Asp Leu Pro Ala Ala Asp Ala Arg Arg Leu Arg Arg Trp 
        355                 360                 365             


Ala Asn Val Leu Arg Arg Ala Tyr Gly Asn Asp Pro Asn Ala Lys Ala 
    370                 375                 380                 


Pro Arg Leu Ser Val Leu Thr Arg Glu Glu Phe Leu Ala Leu Tyr Gly 
385                 390                 395                 400 


Ser 
    


<210>  425
<211>  282
<212>  PRT
<213>  Streptomyces coelicolor

<400>  425

Met Asn Arg Pro Glu Ala Pro Arg Thr Arg His Gly Phe Pro Thr Gly 
1               5                   10                  15      


Arg Ala Val Tyr Ala Val Ala Pro Val Val Ala Ala Ala Leu Ala His 
            20                  25                  30          


Ile Gly Pro Ala Ala Thr Trp Leu Pro Glu Leu Arg Arg Arg Arg Phe 
        35                  40                  45              


Pro Gly Leu Ala Gly Arg Gly Ser Pro Gly His Val Ala Leu Thr Phe 
    50                  55                  60                  


Asp Asp Gly Pro Asp Pro Ala Ser Thr Pro Arg Phe Leu Asp Thr Leu 
65                  70                  75                  80  


Asp Gly Leu Gly Val Arg Ala Thr Phe Phe Val Leu Gly Glu Asn Ala 
                85                  90                  95      


Leu Arg His Pro Ala Leu Thr Arg Glu Leu Val Arg Arg Gly His Glu 
            100                 105                 110         


Leu Ala Val His Gly Trp Thr His Asp Arg Pro Trp Trp Pro Ser Pro 
        115                 120                 125             


Ala Arg Asp Thr Arg Glu Leu Leu Arg Ala Val Arg Val Val Asp Glu 
    130                 135                 140                 


Val Ser Gly Arg Ala Pro Arg Trp Tyr Arg Pro Pro Tyr Gly Ile Leu 
145                 150                 155                 160 


Thr Ser Gly Arg Trp Ala Ala Ala Arg Arg Ala Gly Leu Arg Pro Val 
                165                 170                 175     


Leu Trp Thr Ala Trp Gly Lys Asp Trp Arg His Asp Ala Thr Pro Ala 
            180                 185                 190         


Ser Val Arg Ala Thr Val Ala Ala Asp Leu Cys Gly Gly Gly Thr Val 
        195                 200                 205             


Leu Leu His Asp Thr Asp His Ala Ser Ala Pro Gly Ser Trp Arg Ala 
    210                 215                 220                 


Thr Leu Gly Ala Leu Pro Asp Ile Val Arg Asp Cys Arg Glu Ala Gly 
225                 230                 235                 240 


Leu Ala Val Gly Pro Leu Gly Glu His Gly Ala Gly Gly Ala Thr Gly 
                245                 250                 255     


Thr Pro Gly Thr Ala Ala Val Ala Gly Thr Ala Gly Thr Ala Gly Thr 
            260                 265                 270         


Ala Ala Ser Phe Arg Ser Pro Ala Pro Gly 
        275                 280         


<210>  426
<211>  219
<212>  PRT
<213>  Mesorhizobium loti

<400>  426

Met Arg Arg Leu Asp Asp Arg Trp Lys Val Gln Ser Glu Cys Ala Asp 
1               5                   10                  15      


Gly Thr Gly Arg Arg Ser Val Tyr Leu Thr Phe Asp Asp Gly Pro Asn 
            20                  25                  30          


Pro Cys Phe Thr Pro Gln Ile Leu Asp Val Leu Ala Gln Asn Arg Val 
        35                  40                  45              


Pro Ala Thr Phe Phe Val Ile Gly Ala Tyr Ala Ala Glu His Pro Glu 
    50                  55                  60                  


Leu Ile Gln Arg Met Ile Ala Glu Gly His Glu Val Gly Asn His Thr 
65                  70                  75                  80  


Met Ser His Pro Asp Leu Ser Lys Cys Gly Leu Gly Glu Val Gln Arg 
                85                  90                  95      


Glu Val Phe Glu Ala Asn Gln Ala Ile Met Leu Ala Cys Pro Gln Ala 
            100                 105                 110         


Ser Ile Arg Tyr Ile Arg Ala Pro Tyr Gly Ala Trp Ser Glu Glu Val 
        115                 120                 125             


Phe Thr Ala Ser Glu Ile Ala Gly Leu Ala Ala Leu His Trp Ser Ile 
    130                 135                 140                 


Asp Pro Arg Asp Trp Ser Arg Pro Gly Thr Asp Ala Ile Val Asp Ala 
145                 150                 155                 160 


Val Leu Ala Ser Val Arg Pro Gly Ala Ile Val Leu Leu His Asp Gly 
                165                 170                 175     


Cys Pro Pro Asp Glu Ser Thr Arg Ser Thr Gln Ala Ser Leu Arg Asn 
            180                 185                 190         


Gln Thr Val Met Ala Leu Ser Asn Leu Ile Pro Ala Leu Asp Ala Cys 
        195                 200                 205             


Gly Tyr Glu Ile Arg Ser Leu Pro Glu His His 
    210                 215                 


<210>  427
<211>  201
<212>  PRT
<213>  Streptomyces coelicolor

<400>  427

Met Arg Ser Glu Pro Ile Leu Arg Met Thr Gly Arg Gly Arg Thr Met 
1               5                   10                  15      


Leu Leu Thr Phe Asp Asp Gly Pro His Pro Glu Tyr Thr Pro Lys Ile 
            20                  25                  30          


Leu Asp Thr Leu Ala Lys Tyr Glu Val Arg Ala Thr Phe Phe Val Cys 
        35                  40                  45              


Gly Glu Met Ala Asp Tyr Asn Arg Asp Leu Leu Thr Arg Met Ala Asp 
    50                  55                  60                  


Glu Gly His Val Val Gly Asn His Thr Trp Ser His Pro Leu Leu Thr 
65                  70                  75                  80  


Lys Leu Thr Arg Arg Arg Ile Arg Ser Glu Met Glu Arg Thr Ser Glu 
                85                  90                  95      


Val Val Glu Gln Ala Tyr Gly Glu Ala Pro Arg Trp Phe Arg Ala Pro 
            100                 105                 110         


Tyr Gly Ala Trp Asn Arg Ala Ala Phe Gln Leu Gly Ser Glu Leu Gly 
        115                 120                 125             


Met Glu Pro Leu Ala Trp Thr Val Asp Thr Leu Asp Trp Thr Thr Pro 
    130                 135                 140                 


Gly Thr Gly Thr Ile Val Asp Arg Val Glu Glu Gly Ala Ala Pro Gly 
145                 150                 155                 160 


Val Val Val Leu Ser His Asp Ala Gly Gly Asp Arg Ser Gln Ser Val 
                165                 170                 175     


Arg Ala Leu Arg Arg Tyr Leu Pro Glu Leu Leu Asp Ser Gly Tyr His 
            180                 185                 190         


Leu Thr Val Pro Arg Arg Arg Leu Ile 
        195                 200     


<210>  428
<211>  1209
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 421

<400>  428
gtgggactcg ttcatccccg agtcgggcat gcagtacctc atcatctgtg gccacaatcg     60

tcgactggag cgccgcttct ccgcgattca gagcgagcgc gtccgcgtgt tcgggtatac    120

caacgagatc gagaagttca tggcgatggc ggatctcatc gtcacgaagc cgggcgggct    180

gacgctgacg gagtccatcg cgatgcgcct gcccctcctc atctatcggc cgattccagg    240

tcaggaggag gcgaatgcgc ggttcgccga gcaggcgggt gtggcggtgt gcgtgaagtc    300

tccggcggaa gctcaggcgt tcttgctctc ggtgcgcgaa gacccgtcca tcctgagccg    360

catgcgcgag gcgtgcagcg cgatgccgag ctgtggcgcg gcggagcgca tcgcgcaaaa    420

gatcatgctg tatgccacga agaagcttcc gtgccgctcc gtgtcgccgg agtggccgcc    480

cgagcttctt ccgacgtgag agggagcgcc gtgatcgggt ggttggtcgc cgtggtcctc    540

gccgtcctgg tggtgtacgc ggggctgcct ttcgtctgga cgcggggctt ggggcgttcc    600

tgcattcgca gaacgccgaa gcccgggtgc gtggcgctca cctttgacga tggccctcat    660

cccgtgtaca cgccccggct tctgaacgcg ctcagggaag cgggagcgag agccacgttc    720

ttcgtgatcg ccgagcacgc cctccgtcat cccgagattg tcgaacggat gctggcggag    780

gggcacgaag tgcaggtgca tgggtatcgc cattggtttg tgccgctgtt gccccccgga    840

ctcacggcgc gccaatgcgt gggggccagg gacatcttgg cgcagcggtt cggcattgac    900

ccccgggtct accggccgac ctggggagcg tgcaacctgg cgacgctcgt gatgctcagg    960

cgatcgcgca tgtcgatgct gttgtggagc gtcatggtgg gcgactggcg ccggacacct   1020

ccagaggagc tggcgcgccg cattcttgcc aagctcgacg cgcgctcggt gattgtgctc   1080

cacgacagcg atgagtcccc gggcgcagag cgcggtgcgc cggaaagcgt gattgcggcc   1140

atcccggccg tggtcgagga agtgcgcaga cgcggataca cattcgtgct cgcgtcggaa   1200

tgcgagtag                                                           1209


<210>  429
<211>  1209
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 421

<400>  429
gtgggaatcg ttcatccccg agtcgggcat gcagtacctc atcatctgtg gccacaatcg     60

tcgactggag cgccgcttct ccgcgattca gagcgagcgc gtccgcgtgt tcgggtatac    120

caacgagatc gagaagttca tggcgatggc ggatctcatc gtcacgaagc cgggcgggct    180

gacgctgacg gagtccatcg cgatgcgcct gcccctcctc atctatcggc cgattccagg    240

tcaggaggag gcgaatgcgc ggttcgccga gcaggcgggt gtggcggtgt gcgtgaagtc    300

tccggcggaa gctcaggcgt tcttgctctc ggtgcgcgaa gacccgtcca tcctgagccg    360

catgcgcgag gcgtgcagcg cgatgccgag ctgtggcgcg gcggagcgca tcgcgcaaaa    420

gatcatgctg tatgccacga agaagcttcc gtgccgctcc gtgtcgccgg agtggccgcc    480

cgagcttctt ccgacgtgag agggagcgcc gtgatcgggt ggttggtcgc cgtggtcctc    540

gccgtcctgg tggtgtacgc ggggctgcct ttcgtctgga cgcggggctt ggggcgttcc    600

tgcattcgca gaacgccgaa gcccgggtgc gtggcgctca cctttgacga tggccctcat    660

cccgtgtaca cgccccggct tctgaacgcg ctcagggaag cgggagcgag agccacgttc    720

ttcgtgatcg ccgagcacgc cctccgtcat cccgagattg tcgaacggat gctggcggag    780

gggcacgaag tgcaggtgca tgggtatcgc cattggtttg tgccgctgtt gccccccgga    840

ctcacggcgc gccaatgcgt gggggccagg gacatcttgg cgcagcggtt cggcattgac    900

ccccgggtct accggccgac ctggggagcg tgcaacctgg cgacgctcgt gatgctcagg    960

cgatcgcgca tgtcgatgct gttgtggagc gtcatggtgg gcgactggcg ccggacacct   1020

ccagaggagc tggcgcgccg cattcttgcc aagctcgacg cgcgctcggt gattgtgctc   1080

cacgacagcg atgagtcccc gggcgcagag cgcggtgcgc cggaaagcgt gattgcggcc   1140

atcccggccg tggtcgagga agtgcgcaga cgcggataca cattcgtgct cgcgtcggaa   1200

tgcgagtag                                                           1209


<210>  430
<211>  1210
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 421

<400>  430
gtgggagtcc gttcatcccc gagtcgggca tgcagtacct catcatctgt ggccacaatc     60

gtcgactgga gcgccgcttc tccgcgattc agagcgagcg cgtccgcgtg ttcgggtata    120

ccaacgagat cgagaagttc atggcgatgg cggatctcat cgtcacgaag ccgggcgggc    180

tgacgctgac ggagtccatc gcgatgcgcc tgcccctcct catctatcgg ccgattccag    240

gtcaggagga ggcgaatgcg cggttcgccg agcaggcggg tgtggcggtg tgcgtgaagt    300

ctccggcgga agctcaggcg ttcttgctct cggtgcgcga agacccgtcc atcctgagcc    360

gcatgcgcga ggcgtgcagc gcgatgccga gctgtggcgc ggcggagcgc atcgcgcaaa    420

agatcatgct gtatgccacg aagaagcttc cgtgccgctc cgtgtcgccg gagtggccgc    480

ccgagcttct tccgacgtga gagggagcgc cgtgatcggg tggttggtcg ccgtggtcct    540

cgccgtcctg gtggtgtacg cggggctgcc tttcgtctgg acgcggggct tggggcgttc    600

ctgcattcgc agaacgccga agcccgggtg cgtggcgctc acctttgacg atggccctca    660

tcccgtgtac acgccccggc ttctgaacgc gctcagggaa gcgggagcga gagccacgtt    720

cttcgtgatc gccgagcacg ccctccgtca tcccgagatt gtcgaacgga tgctggcgga    780

ggggcacgaa gtgcaggtgc atgggtatcg ccattggttt gtgccgctgt tgccccccgg    840

actcacggcg cgccaatgcg tgggggccag ggacatcttg gcgcagcggt tcggcattga    900

cccccgggtc taccggccga cctggggagc gtgcaacctg gcgacgctcg tgatgctcag    960

gcgatcgcgc atgtcgatgc tgttgtggag cgtcatggtg ggcgactggc gccggacacc   1020

tccagaggag ctggcgcgcc gcattcttgc caagctcgac gcgcgctcgg tgattgtgct   1080

ccacgacagc gatgagtccc cgggcgcaga gcgcggtgcg ccggaaagcg tgattgcggc   1140

catcccggcc gtggtcgagg aagtgcgcag acgcggatac acattcgtgc tcgcgtcgga   1200

atgcgagtag                                                          1210


<210>  431
<211>  1209
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 421

<400>  431
gtgggagtca ttcatccccg agtcgggcat gcagtacctc atcatctgtg gccacaatcg     60

tcgactggag cgccgcttct ccgcgattca gagcgagcgc gtccgcgtgt tcgggtatac    120

caacgagatc gagaagttca tggcgatggc ggatctcatc gtcacgaagc cgggcgggct    180

gacgctgacg gagtccatcg cgatgcgcct gcccctcctc atctatcggc cgattccagg    240

tcaggaggag gcgaatgcgc ggttcgccga gcaggcgggt gtggcggtgt gcgtgaagtc    300

tccggcggaa gctcaggcgt tcttgctctc ggtgcgcgaa gacccgtcca tcctgagccg    360

catgcgcgag gcgtgcagcg cgatgccgag ctgtggcgcg gcggagcgca tcgcgcaaaa    420

gatcatgctg tatgccacga agaagcttcc gtgccgctcc gtgtcgccgg agtggccgcc    480

cgagcttctt ccgacgtgag agggagcgcc gtgatcgggt ggttggtcgc cgtggtcctc    540

gccgtcctgg tggtgtacgc ggggctgcct ttcgtctgga cgcggggctt ggggcgttcc    600

tgcattcgca gaacgccgaa gcccgggtgc gtggcgctca cctttgacga tggccctcat    660

cccgtgtaca cgccccggct tctgaacgcg ctcagggaag cgggagcgag agccacgttc    720

ttcgtgatcg ccgagcacgc cctccgtcat cccgagattg tcgaacggat gctggcggag    780

gggcacgaag tgcaggtgca tgggtatcgc cattggtttg tgccgctgtt gccccccgga    840

ctcacggcgc gccaatgcgt gggggccagg gacatcttgg cgcagcggtt cggcattgac    900

ccccgggtct accggccgac ctggggagcg tgcaacctgg cgacgctcgt gatgctcagg    960

cgatcgcgca tgtcgatgct gttgtggagc gtcatggtgg gcgactggcg ccggacacct   1020

ccagaggagc tggcgcgccg cattcttgcc aagctcgacg cgcgctcggt gattgtgctc   1080

cacgacagcg atgagtcccc gggcgcagag cgcggtgcgc cggaaagcgt gattgcggcc   1140

atcccggccg tggtcgagga agtgcgcaga cgcggataca cattcgtgct cgcgtcggaa   1200

tgcgagtag                                                           1209


<210>  432
<211>  1209
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 421

<400>  432
gtgggagtcg ttcatcccaa ggtcgggcat gcagtacctc atcatctgtg gccacaatcg     60

tcgactggag cgccgcttct ccgcgattca gagcgagcgc gtccgcgtgt tcgggtatac    120

caacgagatc gagaagttca tggcgatggc ggatctcatc gtcacgaagc cgggcgggct    180

gacgctgacg gagtccatcg cgatgcgcct gcccctcctc atctatcggc cgattccagg    240

tcaggaggag gcgaatgcgc ggttcgccga gcaggcgggt gtggcggtgt gcgtgaagtc    300

tccggcggaa gctcaggcgt tcttgctctc ggtgcgcgaa gacccgtcca tcctgagccg    360

catgcgcgag gcgtgcagcg cgatgccgag ctgtggcgcg gcggagcgca tcgcgcaaaa    420

gatcatgctg tatgccacga agaagcttcc gtgccgctcc gtgtcgccgg agtggccgcc    480

cgagcttctt ccgacgtgag agggagcgcc gtgatcgggt ggttggtcgc cgtggtcctc    540

gccgtcctgg tggtgtacgc ggggctgcct ttcgtctgga cgcggggctt ggggcgttcc    600

tgcattcgca gaacgccgaa gcccgggtgc gtggcgctca cctttgacga tggccctcat    660

cccgtgtaca cgccccggct tctgaacgcg ctcagggaag cgggagcgag agccacgttc    720

ttcgtgatcg ccgagcacgc cctccgtcat cccgagattg tcgaacggat gctggcggag    780

gggcacgaag tgcaggtgca tgggtatcgc cattggtttg tgccgctgtt gccccccgga    840

ctcacggcgc gccaatgcgt gggggccagg gacatcttgg cgcagcggtt cggcattgac    900

ccccgggtct accggccgac ctggggagcg tgcaacctgg cgacgctcgt gatgctcagg    960

cgatcgcgca tgtcgatgct gttgtggagc gtcatggtgg gcgactggcg ccggacacct   1020

ccagaggagc tggcgcgccg cattcttgcc aagctcgacg cgcgctcggt gattgtgctc   1080

cacgacagcg atgagtcccc gggcgcagag cgcggtgcgc cggaaagcgt gattgcggcc   1140

atcccggccg tggtcgagga agtgcgcaga cgcggataca cattcgtgct cgcgtcggaa   1200

tgcgagtag                                                           1209


<210>  433
<211>  402
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:422 and encoded by SEQ ID NO:428

<400>  433

Met Gly Leu Val His Pro Arg Val Gly His Ala Val Pro His His Leu 
1               5                   10                  15      


Trp Pro Gln Ser Ser Thr Gly Ala Pro Leu Leu Arg Asp Ser Glu Arg 
            20                  25                  30          


Ala Arg Pro Arg Val Arg Val Tyr Gln Arg Asp Arg Glu Val His Gly 
        35                  40                  45              


Asp Gly Gly Ser His Arg His Glu Ala Gly Arg Ala Asp Ala Asp Gly 
    50                  55                  60                  


Val His Arg Asp Ala Pro Ala Pro Pro His Leu Ser Ala Asp Ser Arg 
65                  70                  75                  80  


Ser Gly Gly Gly Glu Cys Ala Val Arg Arg Ala Gly Gly Cys Gly Gly 
                85                  90                  95      


Val Arg Glu Val Ser Gly Gly Ser Ser Gly Val Leu Ala Leu Gly Ala 
            100                 105                 110         


Arg Arg Pro Val His Pro Glu Pro His Ala Arg Gly Val Gln Arg Asp 
        115                 120                 125             


Ala Glu Leu Trp Arg Gly Gly Ala His Arg Ala Lys Asp His Ala Val 
    130                 135                 140                 


Cys His Glu Glu Ala Ser Val Pro Leu Arg Val Ala Gly Val Ala Ala 
145                 150                 155                 160 


Arg Ala Ser Ser Asp Val Arg Gly Ser Ala Val Ile Gly Trp Leu Val 
                165                 170                 175     


Ala Val Val Leu Ala Val Leu Val Val Tyr Ala Gly Leu Pro Phe Val 
            180                 185                 190         


Trp Thr Arg Gly Leu Gly Arg Ser Cys Ile Arg Arg Thr Pro Lys Pro 
        195                 200                 205             


Gly Cys Val Ala Leu Thr Phe Asp Asp Gly Pro His Pro Val Tyr Thr 
    210                 215                 220                 


Pro Arg Leu Leu Asn Ala Leu Arg Glu Ala Gly Ala Arg Ala Thr Phe 
225                 230                 235                 240 


Phe Val Ile Ala Glu His Ala Leu Arg His Pro Glu Ile Val Glu Arg 
                245                 250                 255     


Met Leu Ala Glu Gly His Glu Val Gln Val His Gly Tyr Arg His Trp 
            260                 265                 270         


Phe Val Pro Leu Leu Pro Pro Gly Leu Thr Ala Arg Gln Cys Val Gly 
        275                 280                 285             


Ala Arg Asp Ile Leu Ala Gln Arg Phe Gly Ile Asp Pro Arg Val Tyr 
    290                 295                 300                 


Arg Pro Thr Trp Gly Ala Cys Asn Leu Ala Thr Leu Val Met Leu Arg 
305                 310                 315                 320 


Arg Ser Arg Met Ser Met Leu Leu Trp Ser Val Met Val Gly Asp Trp 
                325                 330                 335     


Arg Arg Thr Pro Pro Glu Glu Leu Ala Arg Arg Ile Leu Ala Lys Leu 
            340                 345                 350         


Asp Ala Arg Ser Val Ile Val Leu His Asp Ser Asp Glu Ser Pro Gly 
        355                 360                 365             


Ala Glu Arg Gly Ala Pro Glu Ser Val Ile Ala Ala Ile Pro Ala Val 
    370                 375                 380                 


Val Glu Glu Val Arg Arg Arg Gly Tyr Thr Phe Val Leu Ala Ser Glu 
385                 390                 395                 400 


Cys Glu 
        


<210>  434
<211>  402
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:422 and encoded by SEQ ID NO:429

<400>  434

Met Gly Ile Val His Pro Arg Val Gly His Ala Val Pro His His Leu 
1               5                   10                  15      


Trp Pro Gln Ser Ser Thr Gly Ala Pro Leu Leu Arg Asp Ser Glu Arg 
            20                  25                  30          


Ala Arg Pro Arg Val Arg Val Tyr Gln Arg Asp Arg Glu Val His Gly 
        35                  40                  45              


Asp Gly Gly Ser His Arg His Glu Ala Gly Arg Ala Asp Ala Asp Gly 
    50                  55                  60                  


Val His Arg Asp Ala Pro Ala Pro Pro His Leu Ser Ala Asp Ser Arg 
65                  70                  75                  80  


Ser Gly Gly Gly Glu Cys Ala Val Arg Arg Ala Gly Gly Cys Gly Gly 
                85                  90                  95      


Val Arg Glu Val Ser Gly Gly Ser Ser Gly Val Leu Ala Leu Gly Ala 
            100                 105                 110         


Arg Arg Pro Val His Pro Glu Pro His Ala Arg Gly Val Gln Arg Asp 
        115                 120                 125             


Ala Glu Leu Trp Arg Gly Gly Ala His Arg Ala Lys Asp His Ala Val 
    130                 135                 140                 


Cys His Glu Glu Ala Ser Val Pro Leu Arg Val Ala Gly Val Ala Ala 
145                 150                 155                 160 


Arg Ala Ser Ser Asp Val Arg Gly Ser Ala Val Ile Gly Trp Leu Val 
                165                 170                 175     


Ala Val Val Leu Ala Val Leu Val Val Tyr Ala Gly Leu Pro Phe Val 
            180                 185                 190         


Trp Thr Arg Gly Leu Gly Arg Ser Cys Ile Arg Arg Thr Pro Lys Pro 
        195                 200                 205             


Gly Cys Val Ala Leu Thr Phe Asp Asp Gly Pro His Pro Val Tyr Thr 
    210                 215                 220                 


Pro Arg Leu Leu Asn Ala Leu Arg Glu Ala Gly Ala Arg Ala Thr Phe 
225                 230                 235                 240 


Phe Val Ile Ala Glu His Ala Leu Arg His Pro Glu Ile Val Glu Arg 
                245                 250                 255     


Met Leu Ala Glu Gly His Glu Val Gln Val His Gly Tyr Arg His Trp 
            260                 265                 270         


Phe Val Pro Leu Leu Pro Pro Gly Leu Thr Ala Arg Gln Cys Val Gly 
        275                 280                 285             


Ala Arg Asp Ile Leu Ala Gln Arg Phe Gly Ile Asp Pro Arg Val Tyr 
    290                 295                 300                 


Arg Pro Thr Trp Gly Ala Cys Asn Leu Ala Thr Leu Val Met Leu Arg 
305                 310                 315                 320 


Arg Ser Arg Met Ser Met Leu Leu Trp Ser Val Met Val Gly Asp Trp 
                325                 330                 335     


Arg Arg Thr Pro Pro Glu Glu Leu Ala Arg Arg Ile Leu Ala Lys Leu 
            340                 345                 350         


Asp Ala Arg Ser Val Ile Val Leu His Asp Ser Asp Glu Ser Pro Gly 
        355                 360                 365             


Ala Glu Arg Gly Ala Pro Glu Ser Val Ile Ala Ala Ile Pro Ala Val 
    370                 375                 380                 


Val Glu Glu Val Arg Arg Arg Gly Tyr Thr Phe Val Leu Ala Ser Glu 
385                 390                 395                 400 


Cys Glu 
        


<210>  435
<211>  402
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:422 and encoded by SEQ ID NO:430

<400>  435

Met Gly Val Leu His Pro Arg Val Gly His Ala Val Pro His His Leu 
1               5                   10                  15      


Trp Pro Gln Ser Ser Thr Gly Ala Pro Leu Leu Arg Asp Ser Glu Arg 
            20                  25                  30          


Ala Arg Pro Arg Val Arg Val Tyr Gln Arg Asp Arg Glu Val His Gly 
        35                  40                  45              


Asp Gly Gly Ser His Arg His Glu Ala Gly Arg Ala Asp Ala Asp Gly 
    50                  55                  60                  


Val His Arg Asp Ala Pro Ala Pro Pro His Leu Ser Ala Asp Ser Arg 
65                  70                  75                  80  


Ser Gly Gly Gly Glu Cys Ala Val Arg Arg Ala Gly Gly Cys Gly Gly 
                85                  90                  95      


Val Arg Glu Val Ser Gly Gly Ser Ser Gly Val Leu Ala Leu Gly Ala 
            100                 105                 110         


Arg Arg Pro Val His Pro Glu Pro His Ala Arg Gly Val Gln Arg Asp 
        115                 120                 125             


Ala Glu Leu Trp Arg Gly Gly Ala His Arg Ala Lys Asp His Ala Val 
    130                 135                 140                 


Cys His Glu Glu Ala Ser Val Pro Leu Arg Val Ala Gly Val Ala Ala 
145                 150                 155                 160 


Arg Ala Ser Ser Asp Val Arg Gly Ser Ala Val Ile Gly Trp Leu Val 
                165                 170                 175     


Ala Val Val Leu Ala Val Leu Val Val Tyr Ala Gly Leu Pro Phe Val 
            180                 185                 190         


Trp Thr Arg Gly Leu Gly Arg Ser Cys Ile Arg Arg Thr Pro Lys Pro 
        195                 200                 205             


Gly Cys Val Ala Leu Thr Phe Asp Asp Gly Pro His Pro Val Tyr Thr 
    210                 215                 220                 


Pro Arg Leu Leu Asn Ala Leu Arg Glu Ala Gly Ala Arg Ala Thr Phe 
225                 230                 235                 240 


Phe Val Ile Ala Glu His Ala Leu Arg His Pro Glu Ile Val Glu Arg 
                245                 250                 255     


Met Leu Ala Glu Gly His Glu Val Gln Val His Gly Tyr Arg His Trp 
            260                 265                 270         


Phe Val Pro Leu Leu Pro Pro Gly Leu Thr Ala Arg Gln Cys Val Gly 
        275                 280                 285             


Ala Arg Asp Ile Leu Ala Gln Arg Phe Gly Ile Asp Pro Arg Val Tyr 
    290                 295                 300                 


Arg Pro Thr Trp Gly Ala Cys Asn Leu Ala Thr Leu Val Met Leu Arg 
305                 310                 315                 320 


Arg Ser Arg Met Ser Met Leu Leu Trp Ser Val Met Val Gly Asp Trp 
                325                 330                 335     


Arg Arg Thr Pro Pro Glu Glu Leu Ala Arg Arg Ile Leu Ala Lys Leu 
            340                 345                 350         


Asp Ala Arg Ser Val Ile Val Leu His Asp Ser Asp Glu Ser Pro Gly 
        355                 360                 365             


Ala Glu Arg Gly Ala Pro Glu Ser Val Ile Ala Ala Ile Pro Ala Val 
    370                 375                 380                 


Val Glu Glu Val Arg Arg Arg Gly Tyr Thr Phe Val Leu Ala Ser Glu 
385                 390                 395                 400 


Cys Glu 
        


<210>  436
<211>  402
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:422 and encoded by SEQ ID NO:431

<400>  436

Met Gly Val Ile His Pro Arg Val Gly His Ala Val Pro His His Leu 
1               5                   10                  15      


Trp Pro Gln Ser Ser Thr Gly Ala Pro Leu Leu Arg Asp Ser Glu Arg 
            20                  25                  30          


Ala Arg Pro Arg Val Arg Val Tyr Gln Arg Asp Arg Glu Val His Gly 
        35                  40                  45              


Asp Gly Gly Ser His Arg His Glu Ala Gly Arg Ala Asp Ala Asp Gly 
    50                  55                  60                  


Val His Arg Asp Ala Pro Ala Pro Pro His Leu Ser Ala Asp Ser Arg 
65                  70                  75                  80  


Ser Gly Gly Gly Glu Cys Ala Val Arg Arg Ala Gly Gly Cys Gly Gly 
                85                  90                  95      


Val Arg Glu Val Ser Gly Gly Ser Ser Gly Val Leu Ala Leu Gly Ala 
            100                 105                 110         


Arg Arg Pro Val His Pro Glu Pro His Ala Arg Gly Val Gln Arg Asp 
        115                 120                 125             


Ala Glu Leu Trp Arg Gly Gly Ala His Arg Ala Lys Asp His Ala Val 
    130                 135                 140                 


Cys His Glu Glu Ala Ser Val Pro Leu Arg Val Ala Gly Val Ala Ala 
145                 150                 155                 160 


Arg Ala Ser Ser Asp Val Arg Gly Ser Ala Val Ile Gly Trp Leu Val 
                165                 170                 175     


Ala Val Val Leu Ala Val Leu Val Val Tyr Ala Gly Leu Pro Phe Val 
            180                 185                 190         


Trp Thr Arg Gly Leu Gly Arg Ser Cys Ile Arg Arg Thr Pro Lys Pro 
        195                 200                 205             


Gly Cys Val Ala Leu Thr Phe Asp Asp Gly Pro His Pro Val Tyr Thr 
    210                 215                 220                 


Pro Arg Leu Leu Asn Ala Leu Arg Glu Ala Gly Ala Arg Ala Thr Phe 
225                 230                 235                 240 


Phe Val Ile Ala Glu His Ala Leu Arg His Pro Glu Ile Val Glu Arg 
                245                 250                 255     


Met Leu Ala Glu Gly His Glu Val Gln Val His Gly Tyr Arg His Trp 
            260                 265                 270         


Phe Val Pro Leu Leu Pro Pro Gly Leu Thr Ala Arg Gln Cys Val Gly 
        275                 280                 285             


Ala Arg Asp Ile Leu Ala Gln Arg Phe Gly Ile Asp Pro Arg Val Tyr 
    290                 295                 300                 


Arg Pro Thr Trp Gly Ala Cys Asn Leu Ala Thr Leu Val Met Leu Arg 
305                 310                 315                 320 


Arg Ser Arg Met Ser Met Leu Leu Trp Ser Val Met Val Gly Asp Trp 
                325                 330                 335     


Arg Arg Thr Pro Pro Glu Glu Leu Ala Arg Arg Ile Leu Ala Lys Leu 
            340                 345                 350         


Asp Ala Arg Ser Val Ile Val Leu His Asp Ser Asp Glu Ser Pro Gly 
        355                 360                 365             


Ala Glu Arg Gly Ala Pro Glu Ser Val Ile Ala Ala Ile Pro Ala Val 
    370                 375                 380                 


Val Glu Glu Val Arg Arg Arg Gly Tyr Thr Phe Val Leu Ala Ser Glu 
385                 390                 395                 400 


Cys Glu 
        


<210>  437
<211>  402
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:422 and encoded by SEQ ID NO:432

<400>  437

Met Gly Val Val His Pro Lys Val Gly His Ala Val Pro His His Leu 
1               5                   10                  15      


Trp Pro Gln Ser Ser Thr Gly Ala Pro Leu Leu Arg Asp Ser Glu Arg 
            20                  25                  30          


Ala Arg Pro Arg Val Arg Val Tyr Gln Arg Asp Arg Glu Val His Gly 
        35                  40                  45              


Asp Gly Gly Ser His Arg His Glu Ala Gly Arg Ala Asp Ala Asp Gly 
    50                  55                  60                  


Val His Arg Asp Ala Pro Ala Pro Pro His Leu Ser Ala Asp Ser Arg 
65                  70                  75                  80  


Ser Gly Gly Gly Glu Cys Ala Val Arg Arg Ala Gly Gly Cys Gly Gly 
                85                  90                  95      


Val Arg Glu Val Ser Gly Gly Ser Ser Gly Val Leu Ala Leu Gly Ala 
            100                 105                 110         


Arg Arg Pro Val His Pro Glu Pro His Ala Arg Gly Val Gln Arg Asp 
        115                 120                 125             


Ala Glu Leu Trp Arg Gly Gly Ala His Arg Ala Lys Asp His Ala Val 
    130                 135                 140                 


Cys His Glu Glu Ala Ser Val Pro Leu Arg Val Ala Gly Val Ala Ala 
145                 150                 155                 160 


Arg Ala Ser Ser Asp Val Arg Gly Ser Ala Val Ile Gly Trp Leu Val 
                165                 170                 175     


Ala Val Val Leu Ala Val Leu Val Val Tyr Ala Gly Leu Pro Phe Val 
            180                 185                 190         


Trp Thr Arg Gly Leu Gly Arg Ser Cys Ile Arg Arg Thr Pro Lys Pro 
        195                 200                 205             


Gly Cys Val Ala Leu Thr Phe Asp Asp Gly Pro His Pro Val Tyr Thr 
    210                 215                 220                 


Pro Arg Leu Leu Asn Ala Leu Arg Glu Ala Gly Ala Arg Ala Thr Phe 
225                 230                 235                 240 


Phe Val Ile Ala Glu His Ala Leu Arg His Pro Glu Ile Val Glu Arg 
                245                 250                 255     


Met Leu Ala Glu Gly His Glu Val Gln Val His Gly Tyr Arg His Trp 
            260                 265                 270         


Phe Val Pro Leu Leu Pro Pro Gly Leu Thr Ala Arg Gln Cys Val Gly 
        275                 280                 285             


Ala Arg Asp Ile Leu Ala Gln Arg Phe Gly Ile Asp Pro Arg Val Tyr 
    290                 295                 300                 


Arg Pro Thr Trp Gly Ala Cys Asn Leu Ala Thr Leu Val Met Leu Arg 
305                 310                 315                 320 


Arg Ser Arg Met Ser Met Leu Leu Trp Ser Val Met Val Gly Asp Trp 
                325                 330                 335     


Arg Arg Thr Pro Pro Glu Glu Leu Ala Arg Arg Ile Leu Ala Lys Leu 
            340                 345                 350         


Asp Ala Arg Ser Val Ile Val Leu His Asp Ser Asp Glu Ser Pro Gly 
        355                 360                 365             


Ala Glu Arg Gly Ala Pro Glu Ser Val Ile Ala Ala Ile Pro Ala Val 
    370                 375                 380                 


Val Glu Glu Val Arg Arg Arg Gly Tyr Thr Phe Val Leu Ala Ser Glu 
385                 390                 395                 400 


Cys Glu 
        


<210>  438
<211>  1638
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  438
ttgtttccta cccgaggccc cgagtcaaga cagctacttc caaccgcgcg ttcacgcccg     60

ccacgcagcc cgcccgcgcg tggcccgcgt gcgctccttc gatcgcgccc gctgcagcgc    120

gcgaaaaaac gccttcgcga gcgcctcgtg tccctcgtcc gtcggatgaa tcggattgcg    180

gaacaggcgc agatcccgga actgcccact tcggtagtgc tcgacatagg ccggctcgtg    240

cccgcgaaac gccttgtagg tctccaccac cacgagcccg tgacgaagcg cgatccggcg    300

gacgcgatcg ttgtactcct gcgtcacctc ctcggccaag gcgaaattcg gaaagggatt    360

gtagagggtc gcaataccga acgtgctgtg cgggcgtttg caccattcca ccaagcgctc    420

cacgtcctcc tcagagcggc gcatgacgtc ctgaatgaga tcggctcgcc gcgtgaggat    480

cgccggcgcg cttcgcagga gatcgtttcc gccgatcatg agcgtgacga tctcggcctc    540

ctcgacgata cagggcggga ggtcctgaag cgatttgaac agctgcctcg ccgtccaccc    600

cggcttcgcc tggatatgca acgtcgtgcg gacctggcgg gcgaagcggg cgcgaaggcg    660

ctgcgcaaag ctcttctccg gcgcactcgc accgtagcca tatgtaatgg agtcgccgag    720

cgcgagcatc agcatgatca tcgcctcctg ggtgagtcgc tgatcgtaag ctatgggctt    780

tcccggcgat tggtcacaag aggcgcccac gcgccggtgg cgagatcgca taggcggtgc    840

ggccgctgca aacactgcag gcagaatcac aagggaggtt ggccaatgcg gagcttctgg    900

aagcgacttc gcgcgggcgt cgccgcgctc acggccgcat gcgtgtgcgc cgtgtcgtgc    960

atgagcctgc aagccgggtc ggtgcgcgcc gccgatacga aggctcaggc cccgaaggcc   1020

gtgtacaagg tggatacgaa ggagaaagtg gtggccctga cctttgacat ctcctggggg   1080

catcgcacgc ccgagccggt gttggagacg ctgaagaaat gcggtgtgac gaaggcgacg   1140

ttttttctga gcgggccctg gacgatgcac catcccgaga tcgccaagaa gatcaaggcc   1200

atgggctatg aaatcgggag ccacggatac ctgcacaagg actattcgaa ttacccggat   1260

tcctggatcc gagagcaggc gatgctcgcg gacaaggcca ttcagcaggt cacgggcgtg   1320

aaaccgaagc tgttccggac gccgaacggc gacctcaatc tgcgggtcat tcgctgtctc   1380

acgagcatgg gctacacggt ggtacagtgg aacaccgact cgctcgactg gaagaaccca   1440

ggcgtggacg cgattgtcaa ccgggtgacg aagcgggtgg tgccgggcga catcgtgctg   1500

atgcacgcca gcgactcttc gaagcagatc gtggaggcgc tgccgaggat cgtcgaaaat   1560

ctgcgccagc aggggtatcg gtttgtgacg gtatccgagc tcctggcggg cgccaacgtg   1620

cagtccaaag tgcagtga                                                 1638


<210>  439
<211>  545
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  439

Met Phe Pro Thr Arg Gly Pro Glu Ser Arg Gln Leu Leu Pro Thr Ala 
1               5                   10                  15      


Arg Ser Arg Pro Pro Arg Ser Pro Pro Ala Arg Gly Pro Arg Ala Leu 
            20                  25                  30          


Leu Arg Ser Arg Pro Leu Gln Arg Ala Lys Lys Arg Leu Arg Glu Arg 
        35                  40                  45              


Leu Val Ser Leu Val Arg Arg Met Asn Arg Ile Ala Glu Gln Ala Gln 
    50                  55                  60                  


Ile Pro Glu Leu Pro Thr Ser Val Val Leu Asp Ile Gly Arg Leu Val 
65                  70                  75                  80  


Pro Ala Lys Arg Leu Val Gly Leu His His His Glu Pro Val Thr Lys 
                85                  90                  95      


Arg Asp Pro Ala Asp Ala Ile Val Val Leu Leu Arg His Leu Leu Gly 
            100                 105                 110         


Gln Gly Glu Ile Arg Lys Gly Ile Val Glu Gly Arg Asn Thr Glu Arg 
        115                 120                 125             


Ala Val Arg Ala Phe Ala Pro Phe His Gln Ala Leu His Val Leu Leu 
    130                 135                 140                 


Arg Ala Ala His Asp Val Leu Asn Glu Ile Gly Ser Pro Arg Glu Asp 
145                 150                 155                 160 


Arg Arg Arg Ala Ser Gln Glu Ile Val Ser Ala Asp His Glu Arg Asp 
                165                 170                 175     


Asp Leu Gly Leu Leu Asp Asp Thr Gly Arg Glu Val Leu Lys Arg Phe 
            180                 185                 190         


Glu Gln Leu Pro Arg Arg Pro Pro Arg Leu Arg Leu Asp Met Gln Arg 
        195                 200                 205             


Arg Ala Asp Leu Ala Gly Glu Ala Gly Ala Lys Ala Leu Arg Lys Ala 
    210                 215                 220                 


Leu Leu Arg Arg Thr Arg Thr Val Ala Ile Cys Asn Gly Val Ala Glu 
225                 230                 235                 240 


Arg Glu His Gln His Asp His Arg Leu Leu Gly Glu Ser Leu Ile Val 
                245                 250                 255     


Ser Tyr Gly Leu Ser Arg Arg Leu Val Thr Arg Gly Ala His Ala Pro 
            260                 265                 270         


Val Ala Arg Ser His Arg Arg Cys Gly Arg Cys Lys His Cys Arg Gln 
        275                 280                 285             


Asn His Lys Gly Gly Trp Pro Met Arg Ser Phe Trp Lys Arg Leu Arg 
    290                 295                 300                 


Ala Gly Val Ala Ala Leu Thr Ala Ala Cys Val Cys Ala Val Ser Cys 
305                 310                 315                 320 


Met Ser Leu Gln Ala Gly Ser Val Arg Ala Ala Asp Thr Lys Ala Gln 
                325                 330                 335     


Ala Pro Lys Ala Val Tyr Lys Val Asp Thr Lys Glu Lys Val Val Ala 
            340                 345                 350         


Leu Thr Phe Asp Ile Ser Trp Gly His Arg Thr Pro Glu Pro Val Leu 
        355                 360                 365             


Glu Thr Leu Lys Lys Cys Gly Val Thr Lys Ala Thr Phe Phe Leu Ser 
    370                 375                 380                 


Gly Pro Trp Thr Met His His Pro Glu Ile Ala Lys Lys Ile Lys Ala 
385                 390                 395                 400 


Met Gly Tyr Glu Ile Gly Ser His Gly Tyr Leu His Lys Asp Tyr Ser 
                405                 410                 415     


Asn Tyr Pro Asp Ser Trp Ile Arg Glu Gln Ala Met Leu Ala Asp Lys 
            420                 425                 430         


Ala Ile Gln Gln Val Thr Gly Val Lys Pro Lys Leu Phe Arg Thr Pro 
        435                 440                 445             


Asn Gly Asp Leu Asn Leu Arg Val Ile Arg Cys Leu Thr Ser Met Gly 
    450                 455                 460                 


Tyr Thr Val Val Gln Trp Asn Thr Asp Ser Leu Asp Trp Lys Asn Pro 
465                 470                 475                 480 


Gly Val Asp Ala Ile Val Asn Arg Val Thr Lys Arg Val Val Pro Gly 
                485                 490                 495     


Asp Ile Val Leu Met His Ala Ser Asp Ser Ser Lys Gln Ile Val Glu 
            500                 505                 510         


Ala Leu Pro Arg Ile Val Glu Asn Leu Arg Gln Gln Gly Tyr Arg Phe 
        515                 520                 525             


Val Thr Val Ser Glu Leu Leu Ala Gly Ala Asn Val Gln Ser Lys Val 
    530                 535                 540                 


Gln 
545 


<210>  440
<211>  254
<212>  PRT
<213>  Bacillus licheniformis

<400>  440

Met Asn His Phe Tyr Val Trp His Ile Lys Arg Ile Lys Gln Leu Ile 
1               5                   10                  15      


Ile Ile Met Ile Ala Ala Phe Ala Thr Ala Ser Phe Phe Tyr Val Gln 
            20                  25                  30          


Asn Leu Leu Pro Leu Pro Val Phe Ser Thr Glu Gly Gly Ala Lys Ala 
        35                  40                  45              


Val Tyr Arg Gly Asp Ser Asp Thr Asn Glu Val Ala Leu Thr Phe Asn 
    50                  55                  60                  


Ile Ser Trp Gly Asp Gln Lys Ala Met Pro Ile Leu Asp Thr Leu Lys 
65                  70                  75                  80  


Ala Asn Gly Ile Lys Asp Ala Thr Phe Phe Leu Ser Ala Ser Trp Ala 
                85                  90                  95      


Glu Arg His Pro Asp Val Val Glu Arg Ile Arg Lys Asp Gly His Gln 
            100                 105                 110         


Ile Gly Ser Met Gly Tyr Ala Tyr Lys Asn Tyr Ser Gln Met Lys Lys 
        115                 120                 125             


Ser Glu Ile Lys Lys Asp Leu Ala Lys Ala Arg His Ser Phe Gln Lys 
    130                 135                 140                 


Leu Gly Leu Asp Asp Leu Thr Leu Leu Arg Pro Pro Thr Gly Gln Phe 
145                 150                 155                 160 


Asn Lys Asp Val Leu Asp Val Ala Lys Gln Tyr Gly Tyr Thr Val Val 
                165                 170                 175     


His Tyr Ser Ile Asn Ser Asp Asp Trp Thr Asn Pro Gly Val Gln Lys 
            180                 185                 190         


Ile Val Gln Asn Val Asn Gly Thr Val Asn Ala Gly Asp Ile Val Leu 
        195                 200                 205             


Phe His Ala Ser Asp Ser Ala Lys Gln Thr Lys Glu Ala Leu Pro Glu 
    210                 215                 220                 


Ile Val His His Leu Arg Ser Lys Gly Leu Lys Asn Val Thr Val Ser 
225                 230                 235                 240 


Glu Leu Ile Ala Asn Thr Asp Ala Lys Ser Ser Glu Val Lys 
                245                 250                 


<210>  441
<211>  254
<212>  PRT
<213>  Bacillus subtilis

<400>  441

Met Asn His Phe Tyr Val Trp His Ile Lys Arg Val Lys Gln Leu Ile 
1               5                   10                  15      


Ile Ile Leu Ile Ala Ala Phe Ala Ala Ala Ser Phe Phe Tyr Ile Gln 
            20                  25                  30          


Arg Ala Val Pro Leu Pro Val Phe Ser Thr Asp Thr Gly Pro Lys Ala 
        35                  40                  45              


Ile Tyr Lys Gly Glu Thr Asp Ser Lys Asp Ile Ser Leu Thr Phe Asp 
    50                  55                  60                  


Ile Ser Trp Gly Asp Glu Arg Ala Glu Pro Ile Leu Asn Thr Leu Lys 
65                  70                  75                  80  


Ala Asn Gly Ile Lys Asn Ala Thr Phe Phe Leu Ser Ala Ser Trp Ala 
                85                  90                  95      


Glu Arg His Pro Asp Thr Val Ala Arg Ile Val Lys Asp Gly His Gln 
            100                 105                 110         


Ile Gly Ser Met Gly Tyr Ala Tyr Lys Asn Tyr Ala Asn Leu Glu Ser 
        115                 120                 125             


Ser Glu Ile Lys Lys Asp Met Asn Arg Ala Gln Thr Ala Phe Glu Lys 
    130                 135                 140                 


Leu Gly Val Lys Asp Ile Gln Leu Leu Arg Pro Pro Thr Gly Gln Phe 
145                 150                 155                 160 


Asn Lys Asn Val Leu Lys Val Ala Lys Gln Tyr Asn Tyr Thr Val Val 
                165                 170                 175     


His Tyr Ser Val Asn Ser Gln Asp Trp Thr Asn Pro Gly Val Glu Lys 
            180                 185                 190         


Ile Ile Asp Asn Val Thr Lys Gln Val Ser Gly Gly Asp Ile Ile Leu 
        195                 200                 205             


Leu His Ala Ser Asp Ser Ala Lys Gln Thr Glu Glu Ala Leu Pro Asp 
    210                 215                 220                 


Ile Ile His Gln Leu Lys Glu Lys Gly Leu Lys Asn Val Thr Val Gly 
225                 230                 235                 240 


Asp Leu Ile Ala Asn Ser Asp Ala Lys Ser Ala Glu Val Lys 
                245                 250                 


<210>  442
<211>  250
<212>  PRT
<213>  Bacillus NRRL B-14911

<400>  442

Met Asn Phe Phe Tyr Val Val Asn Gly Lys Ala Ile Lys Gln Gly Leu 
1               5                   10                  15      


Leu Ile Met Ile Ala Ser Phe Phe Thr Ala Trp Phe Leu Tyr Met Glu 
            20                  25                  30          


Asn Ile Ile His Met Pro Val Phe Ser Ala Asn Asp Gly Pro Lys Ala 
        35                  40                  45              


Ile Tyr Lys Gly Glu Lys Asp Ala Ala Leu Thr Phe Asn Ile Gly Trp 
    50                  55                  60                  


Gly Asp Glu Lys Ala Glu Pro Ile Leu Asp Val Leu Lys Lys Gln Asn 
65                  70                  75                  80  


Val Lys Ala Ala Thr Phe Phe Leu Ser Gly Ser Trp Ala Glu Arg His 
                85                  90                  95      


Pro Glu Leu Val Ala Arg Ile Val Lys Glu Gly Tyr Glu Ile Gly Met 
            100                 105                 110         


Leu Gly Tyr Asp Tyr Lys Asp Tyr Thr Asp Leu Glu Glu Ser Lys Ile 
        115                 120                 125             


Arg Gln Asp Leu Ala Lys Gly Gln Glu Ala Phe Lys Lys Leu Asn Val 
    130                 135                 140                 


Lys Asp Ile Lys Leu Val Arg Ala Pro Thr Gly His Phe Asp Gln Lys 
145                 150                 155                 160 


Thr Leu Asn Val Ala Glu Lys Met Gly Tyr Thr Val Val His Trp Ser 
                165                 170                 175     


Ile Asp Ser Lys Asp Trp Thr Asn Pro Gly Val Glu Arg Ile Ala Glu 
            180                 185                 190         


Asn Ala Ala Lys Ala Gly Lys Gly Asp Ile Ile Leu Leu His Ala Ser 
        195                 200                 205             


Asp Ser Ala Lys Gln Thr Ala Lys Ala Leu Pro Ala Ile Ile Gly Asn 
    210                 215                 220                 


Tyr Lys Asp Lys Gly Leu Lys Leu Val Ser Val Ser Glu Met Met Ala 
225                 230                 235                 240 


Asn Ala Ser Thr Lys Ser Asn Glu Ile Lys 
                245                 250 


<210>  443
<211>  253
<212>  PRT
<213>  Bacillus halodurans

<400>  443

Met Lys Phe Phe Trp Val Leu Arg Ala Lys Lys Ile Lys Gln Leu Thr 
1               5                   10                  15      


Ile Ile Leu Leu Thr Ala Phe Phe Cys Ala Ser Leu Leu Tyr Leu Glu 
            20                  25                  30          


Arg Ser His Leu Met Val Phe Ser Thr Pro Glu Gly Pro Gln Ala Phe 
        35                  40                  45              


His Lys Ala Glu Thr Asp Glu Lys Val Ala Ala Leu Thr Phe Asn Ile 
    50                  55                  60                  


Ser Trp Gly Glu Gln Arg Val Lys Pro Ile Ile Asp Val Leu Gln Ser 
65                  70                  75                  80  


Lys Lys Val Glu Glu Ala Thr Phe Phe Ile Ser Ala Ser Trp Ala Glu 
                85                  90                  95      


Arg His Pro Glu Leu Val Glu Leu Ile Gln Glu Ala Gly Tyr His Ile 
            100                 105                 110         


Gly Ser His Gly Tyr Gln Tyr Lys Asn Tyr Thr Thr Trp Glu Asp Glu 
        115                 120                 125             


Lys Ile Arg Lys Asp Leu Arg Gln Ser Gln Gln Val Ile Ser Ser Ile 
    130                 135                 140                 


Thr Gly Glu Lys Pro Thr Leu Leu Arg Pro Pro Asn Gly Asp Phe Asp 
145                 150                 155                 160 


Lys Arg Val Leu Asn Leu Ala Glu Ser Tyr Asp Tyr Thr Val Val His 
                165                 170                 175     


Trp Ser Ile Asn Ser Arg Asp Tyr Glu Asn Pro Gly Val Asp Ala Ile 
            180                 185                 190         


Val Arg Gln Val Val Asp His Ile Ser Pro Gly Asp Ile Val Leu Met 
        195                 200                 205             


His Ala Ser Asp Ser Ala Lys Gln Thr His Lys Ala Leu Pro Ile Ile 
    210                 215                 220                 


Ile Asp Gln Leu Lys Gly Lys Gly Tyr His Phe Arg Ser Ile Glu Glu 
225                 230                 235                 240 


Leu Met Ala Asp Ala His Pro Thr His Asp Glu Ile Lys 
                245                 250             


<210>  444
<211>  246
<212>  PRT
<213>  Thermosinus carboxydivorans

<400>  444

Met Ile Val Asp Leu Arg Arg Phe Met Gly His Arg His Leu Phe Phe 
1               5                   10                  15      


Gly Ile Ile Gly Ile Phe Ala Ile Ser Thr Leu Tyr Val Gln Ala Ala 
            20                  25                  30          


Asn Ile Ile Ala Gly Gly Pro Ile Ala Ile Ala Gly Thr Asn Thr Asp 
        35                  40                  45              


His Lys Val Val Ala Leu Thr Phe Asp His Ser Trp Gly Asn Lys Phe 
    50                  55                  60                  


Thr Pro Ser Ile Leu Asp Thr Leu Lys Arg His Asn Leu Lys Val Thr 
65                  70                  75                  80  


Phe Phe Ile Met Gly Pro Trp Ala Lys Lys Tyr Pro Glu Val Ala Gln 
                85                  90                  95      


Arg Met Val Ala Asp Gly His Glu Ile Ala Ser His Gly Tyr Arg His 
            100                 105                 110         


Glu Asn Tyr Gly Asp Met Thr Thr Glu Trp Val Lys Glu Asp Ile Leu 
        115                 120                 125             


Lys Ala His Ala Leu Ile Lys Glu Val Thr Gly Val Asp Pro Thr Leu 
    130                 135                 140                 


Ile Arg Pro Pro Asn Gly His Tyr Ser Gln Arg Ser Leu Lys Ala Ala 
145                 150                 155                 160 


Asp Glu Leu Gly Tyr Lys Thr Ile Ile Trp Asn Val Asp Ser Leu Asp 
                165                 170                 175     


Trp Lys Asn Pro Gly Arg Asp Val Ile Ile Glu Arg Val Met Lys Arg 
            180                 185                 190         


Leu Lys Pro Gly Ala Ile Ile Leu Met His Ala Ser Asp Thr Pro Val 
        195                 200                 205             


Gln Thr Ala Glu Ala Leu Pro Ile Leu Leu Glu Lys Ile Lys Ala Glu 
    210                 215                 220                 


Gly Tyr Gln Ile Val Thr Val Ser Glu Leu Leu Ser Lys Tyr Ser Glu 
225                 230                 235                 240 


Lys Gly Ile Gln Arg His 
                245     


<210>  445
<211>  1638
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 438

<400>  445
ttgtttccta ccaaaggccc cgagtcaaga cagctacttc caaccgcgcg ttcacgcccg     60

ccacgcagcc cgcccgcgcg tggcccgcgt gcgctccttc gatcgcgccc gctgcagcgc    120

gcgaaaaaac gccttcgcga gcgcctcgtg tccctcgtcc gtcggatgaa tcggattgcg    180

gaacaggcgc agatcccgga actgcccact tcggtagtgc tcgacatagg ccggctcgtg    240

cccgcgaaac gccttgtagg tctccaccac cacgagcccg tgacgaagcg cgatccggcg    300

gacgcgatcg ttgtactcct gcgtcacctc ctcggccaag gcgaaattcg gaaagggatt    360

gtagagggtc gcaataccga acgtgctgtg cgggcgtttg caccattcca ccaagcgctc    420

cacgtcctcc tcagagcggc gcatgacgtc ctgaatgaga tcggctcgcc gcgtgaggat    480

cgccggcgcg cttcgcagga gatcgtttcc gccgatcatg agcgtgacga tctcggcctc    540

ctcgacgata cagggcggga ggtcctgaag cgatttgaac agctgcctcg ccgtccaccc    600

cggcttcgcc tggatatgca acgtcgtgcg gacctggcgg gcgaagcggg cgcgaaggcg    660

ctgcgcaaag ctcttctccg gcgcactcgc accgtagcca tatgtaatgg agtcgccgag    720

cgcgagcatc agcatgatca tcgcctcctg ggtgagtcgc tgatcgtaag ctatgggctt    780

tcccggcgat tggtcacaag aggcgcccac gcgccggtgg cgagatcgca taggcggtgc    840

ggccgctgca aacactgcag gcagaatcac aagggaggtt ggccaatgcg gagcttctgg    900

aagcgacttc gcgcgggcgt cgccgcgctc acggccgcat gcgtgtgcgc cgtgtcgtgc    960

atgagcctgc aagccgggtc ggtgcgcgcc gccgatacga aggctcaggc cccgaaggcc   1020

gtgtacaagg tggatacgaa ggagaaagtg gtggccctga cctttgacat ctcctggggg   1080

catcgcacgc ccgagccggt gttggagacg ctgaagaaat gcggtgtgac gaaggcgacg   1140

ttttttctga gcgggccctg gacgatgcac catcccgaga tcgccaagaa gatcaaggcc   1200

atgggctatg aaatcgggag ccacggatac ctgcacaagg actattcgaa ttacccggat   1260

tcctggatcc gagagcaggc gatgctcgcg gacaaggcca ttcagcaggt cacgggcgtg   1320

aaaccgaagc tgttccggac gccgaacggc gacctcaatc tgcgggtcat tcgctgtctc   1380

acgagcatgg gctacacggt ggtacagtgg aacaccgact cgctcgactg gaagaaccca   1440

ggcgtggacg cgattgtcaa ccgggtgacg aagcgggtgg tgccgggcga catcgtgctg   1500

atgcacgcca gcgactcttc gaagcagatc gtggaggcgc tgccgaggat cgtcgaaaat   1560

ctgcgccagc aggggtatcg gtttgtgacg gtatccgagc tcctggcggg cgccaacgtg   1620

cagtccaaag tgcagtga                                                 1638


<210>  446
<211>  1638
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 438

<400>  446
ttgtttccta cccgaggccc cgactcaaga cagctacttc caaccgcgcg ttcacgcccg     60

ccacgcagcc cgcccgcgcg tggcccgcgt gcgctccttc gatcgcgccc gctgcagcgc    120

gcgaaaaaac gccttcgcga gcgcctcgtg tccctcgtcc gtcggatgaa tcggattgcg    180

gaacaggcgc agatcccgga actgcccact tcggtagtgc tcgacatagg ccggctcgtg    240

cccgcgaaac gccttgtagg tctccaccac cacgagcccg tgacgaagcg cgatccggcg    300

gacgcgatcg ttgtactcct gcgtcacctc ctcggccaag gcgaaattcg gaaagggatt    360

gtagagggtc gcaataccga acgtgctgtg cgggcgtttg caccattcca ccaagcgctc    420

cacgtcctcc tcagagcggc gcatgacgtc ctgaatgaga tcggctcgcc gcgtgaggat    480

cgccggcgcg cttcgcagga gatcgtttcc gccgatcatg agcgtgacga tctcggcctc    540

ctcgacgata cagggcggga ggtcctgaag cgatttgaac agctgcctcg ccgtccaccc    600

cggcttcgcc tggatatgca acgtcgtgcg gacctggcgg gcgaagcggg cgcgaaggcg    660

ctgcgcaaag ctcttctccg gcgcactcgc accgtagcca tatgtaatgg agtcgccgag    720

cgcgagcatc agcatgatca tcgcctcctg ggtgagtcgc tgatcgtaag ctatgggctt    780

tcccggcgat tggtcacaag aggcgcccac gcgccggtgg cgagatcgca taggcggtgc    840

ggccgctgca aacactgcag gcagaatcac aagggaggtt ggccaatgcg gagcttctgg    900

aagcgacttc gcgcgggcgt cgccgcgctc acggccgcat gcgtgtgcgc cgtgtcgtgc    960

atgagcctgc aagccgggtc ggtgcgcgcc gccgatacga aggctcaggc cccgaaggcc   1020

gtgtacaagg tggatacgaa ggagaaagtg gtggccctga cctttgacat ctcctggggg   1080

catcgcacgc ccgagccggt gttggagacg ctgaagaaat gcggtgtgac gaaggcgacg   1140

ttttttctga gcgggccctg gacgatgcac catcccgaga tcgccaagaa gatcaaggcc   1200

atgggctatg aaatcgggag ccacggatac ctgcacaagg actattcgaa ttacccggat   1260

tcctggatcc gagagcaggc gatgctcgcg gacaaggcca ttcagcaggt cacgggcgtg   1320

aaaccgaagc tgttccggac gccgaacggc gacctcaatc tgcgggtcat tcgctgtctc   1380

acgagcatgg gctacacggt ggtacagtgg aacaccgact cgctcgactg gaagaaccca   1440

ggcgtggacg cgattgtcaa ccgggtgacg aagcgggtgg tgccgggcga catcgtgctg   1500

atgcacgcca gcgactcttc gaagcagatc gtggaggcgc tgccgaggat cgtcgaaaat   1560

ctgcgccagc aggggtatcg gtttgtgacg gtatccgagc tcctggcggg cgccaacgtg   1620

cagtccaaag tgcagtga                                                 1638


<210>  447
<211>  1638
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 438

<400>  447
ttgtttccta cccgaggccc cgagtcaaaa cagctacttc caaccgcgcg ttcacgcccg     60

ccacgcagcc cgcccgcgcg tggcccgcgt gcgctccttc gatcgcgccc gctgcagcgc    120

gcgaaaaaac gccttcgcga gcgcctcgtg tccctcgtcc gtcggatgaa tcggattgcg    180

gaacaggcgc agatcccgga actgcccact tcggtagtgc tcgacatagg ccggctcgtg    240

cccgcgaaac gccttgtagg tctccaccac cacgagcccg tgacgaagcg cgatccggcg    300

gacgcgatcg ttgtactcct gcgtcacctc ctcggccaag gcgaaattcg gaaagggatt    360

gtagagggtc gcaataccga acgtgctgtg cgggcgtttg caccattcca ccaagcgctc    420

cacgtcctcc tcagagcggc gcatgacgtc ctgaatgaga tcggctcgcc gcgtgaggat    480

cgccggcgcg cttcgcagga gatcgtttcc gccgatcatg agcgtgacga tctcggcctc    540

ctcgacgata cagggcggga ggtcctgaag cgatttgaac agctgcctcg ccgtccaccc    600

cggcttcgcc tggatatgca acgtcgtgcg gacctggcgg gcgaagcggg cgcgaaggcg    660

ctgcgcaaag ctcttctccg gcgcactcgc accgtagcca tatgtaatgg agtcgccgag    720

cgcgagcatc agcatgatca tcgcctcctg ggtgagtcgc tgatcgtaag ctatgggctt    780

tcccggcgat tggtcacaag aggcgcccac gcgccggtgg cgagatcgca taggcggtgc    840

ggccgctgca aacactgcag gcagaatcac aagggaggtt ggccaatgcg gagcttctgg    900

aagcgacttc gcgcgggcgt cgccgcgctc acggccgcat gcgtgtgcgc cgtgtcgtgc    960

atgagcctgc aagccgggtc ggtgcgcgcc gccgatacga aggctcaggc cccgaaggcc   1020

gtgtacaagg tggatacgaa ggagaaagtg gtggccctga cctttgacat ctcctggggg   1080

catcgcacgc ccgagccggt gttggagacg ctgaagaaat gcggtgtgac gaaggcgacg   1140

ttttttctga gcgggccctg gacgatgcac catcccgaga tcgccaagaa gatcaaggcc   1200

atgggctatg aaatcgggag ccacggatac ctgcacaagg actattcgaa ttacccggat   1260

tcctggatcc gagagcaggc gatgctcgcg gacaaggcca ttcagcaggt cacgggcgtg   1320

aaaccgaagc tgttccggac gccgaacggc gacctcaatc tgcgggtcat tcgctgtctc   1380

acgagcatgg gctacacggt ggtacagtgg aacaccgact cgctcgactg gaagaaccca   1440

ggcgtggacg cgattgtcaa ccgggtgacg aagcgggtgg tgccgggcga catcgtgctg   1500

atgcacgcca gcgactcttc gaagcagatc gtggaggcgc tgccgaggat cgtcgaaaat   1560

ctgcgccagc aggggtatcg gtttgtgacg gtatccgagc tcctggcggg cgccaacgtg   1620

cagtccaaag tgcagtga                                                 1638


<210>  448
<211>  1638
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 438

<400>  448
ttgtttccta cccgaggccc cgagtcaaga cagatacttc caaccgcgcg ttcacgcccg     60

ccacgcagcc cgcccgcgcg tggcccgcgt gcgctccttc gatcgcgccc gctgcagcgc    120

gcgaaaaaac gccttcgcga gcgcctcgtg tccctcgtcc gtcggatgaa tcggattgcg    180

gaacaggcgc agatcccgga actgcccact tcggtagtgc tcgacatagg ccggctcgtg    240

cccgcgaaac gccttgtagg tctccaccac cacgagcccg tgacgaagcg cgatccggcg    300

gacgcgatcg ttgtactcct gcgtcacctc ctcggccaag gcgaaattcg gaaagggatt    360

gtagagggtc gcaataccga acgtgctgtg cgggcgtttg caccattcca ccaagcgctc    420

cacgtcctcc tcagagcggc gcatgacgtc ctgaatgaga tcggctcgcc gcgtgaggat    480

cgccggcgcg cttcgcagga gatcgtttcc gccgatcatg agcgtgacga tctcggcctc    540

ctcgacgata cagggcggga ggtcctgaag cgatttgaac agctgcctcg ccgtccaccc    600

cggcttcgcc tggatatgca acgtcgtgcg gacctggcgg gcgaagcggg cgcgaaggcg    660

ctgcgcaaag ctcttctccg gcgcactcgc accgtagcca tatgtaatgg agtcgccgag    720

cgcgagcatc agcatgatca tcgcctcctg ggtgagtcgc tgatcgtaag ctatgggctt    780

tcccggcgat tggtcacaag aggcgcccac gcgccggtgg cgagatcgca taggcggtgc    840

ggccgctgca aacactgcag gcagaatcac aagggaggtt ggccaatgcg gagcttctgg    900

aagcgacttc gcgcgggcgt cgccgcgctc acggccgcat gcgtgtgcgc cgtgtcgtgc    960

atgagcctgc aagccgggtc ggtgcgcgcc gccgatacga aggctcaggc cccgaaggcc   1020

gtgtacaagg tggatacgaa ggagaaagtg gtggccctga cctttgacat ctcctggggg   1080

catcgcacgc ccgagccggt gttggagacg ctgaagaaat gcggtgtgac gaaggcgacg   1140

ttttttctga gcgggccctg gacgatgcac catcccgaga tcgccaagaa gatcaaggcc   1200

atgggctatg aaatcgggag ccacggatac ctgcacaagg actattcgaa ttacccggat   1260

tcctggatcc gagagcaggc gatgctcgcg gacaaggcca ttcagcaggt cacgggcgtg   1320

aaaccgaagc tgttccggac gccgaacggc gacctcaatc tgcgggtcat tcgctgtctc   1380

acgagcatgg gctacacggt ggtacagtgg aacaccgact cgctcgactg gaagaaccca   1440

ggcgtggacg cgattgtcaa ccgggtgacg aagcgggtgg tgccgggcga catcgtgctg   1500

atgcacgcca gcgactcttc gaagcagatc gtggaggcgc tgccgaggat cgtcgaaaat   1560

ctgcgccagc aggggtatcg gtttgtgacg gtatccgagc tcctggcggg cgccaacgtg   1620

cagtccaaag tgcagtga                                                 1638


<210>  449
<211>  1638
<212>  DNA
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO 438

<400>  449
ttgtttccta cccgaggccc cgagtcaaga caggtacttc caaccgcgcg ttcacgcccg     60

ccacgcagcc cgcccgcgcg tggcccgcgt gcgctccttc gatcgcgccc gctgcagcgc    120

gcgaaaaaac gccttcgcga gcgcctcgtg tccctcgtcc gtcggatgaa tcggattgcg    180

gaacaggcgc agatcccgga actgcccact tcggtagtgc tcgacatagg ccggctcgtg    240

cccgcgaaac gccttgtagg tctccaccac cacgagcccg tgacgaagcg cgatccggcg    300

gacgcgatcg ttgtactcct gcgtcacctc ctcggccaag gcgaaattcg gaaagggatt    360

gtagagggtc gcaataccga acgtgctgtg cgggcgtttg caccattcca ccaagcgctc    420

cacgtcctcc tcagagcggc gcatgacgtc ctgaatgaga tcggctcgcc gcgtgaggat    480

cgccggcgcg cttcgcagga gatcgtttcc gccgatcatg agcgtgacga tctcggcctc    540

ctcgacgata cagggcggga ggtcctgaag cgatttgaac agctgcctcg ccgtccaccc    600

cggcttcgcc tggatatgca acgtcgtgcg gacctggcgg gcgaagcggg cgcgaaggcg    660

ctgcgcaaag ctcttctccg gcgcactcgc accgtagcca tatgtaatgg agtcgccgag    720

cgcgagcatc agcatgatca tcgcctcctg ggtgagtcgc tgatcgtaag ctatgggctt    780

tcccggcgat tggtcacaag aggcgcccac gcgccggtgg cgagatcgca taggcggtgc    840

ggccgctgca aacactgcag gcagaatcac aagggaggtt ggccaatgcg gagcttctgg    900

aagcgacttc gcgcgggcgt cgccgcgctc acggccgcat gcgtgtgcgc cgtgtcgtgc    960

atgagcctgc aagccgggtc ggtgcgcgcc gccgatacga aggctcaggc cccgaaggcc   1020

gtgtacaagg tggatacgaa ggagaaagtg gtggccctga cctttgacat ctcctggggg   1080

catcgcacgc ccgagccggt gttggagacg ctgaagaaat gcggtgtgac gaaggcgacg   1140

ttttttctga gcgggccctg gacgatgcac catcccgaga tcgccaagaa gatcaaggcc   1200

atgggctatg aaatcgggag ccacggatac ctgcacaagg actattcgaa ttacccggat   1260

tcctggatcc gagagcaggc gatgctcgcg gacaaggcca ttcagcaggt cacgggcgtg   1320

aaaccgaagc tgttccggac gccgaacggc gacctcaatc tgcgggtcat tcgctgtctc   1380

acgagcatgg gctacacggt ggtacagtgg aacaccgact cgctcgactg gaagaaccca   1440

ggcgtggacg cgattgtcaa ccgggtgacg aagcgggtgg tgccgggcga catcgtgctg   1500

atgcacgcca gcgactcttc gaagcagatc gtggaggcgc tgccgaggat cgtcgaaaat   1560

ctgcgccagc aggggtatcg gtttgtgacg gtatccgagc tcctggcggg cgccaacgtg   1620

cagtccaaag tgcagtga                                                 1638


<210>  450
<211>  545
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:439 and encoded by SEQ ID NO:445

<400>  450

Met Phe Pro Thr Lys Gly Pro Glu Ser Arg Gln Leu Leu Pro Thr Ala 
1               5                   10                  15      


Arg Ser Arg Pro Pro Arg Ser Pro Pro Ala Arg Gly Pro Arg Ala Leu 
            20                  25                  30          


Leu Arg Ser Arg Pro Leu Gln Arg Ala Lys Lys Arg Leu Arg Glu Arg 
        35                  40                  45              


Leu Val Ser Leu Val Arg Arg Met Asn Arg Ile Ala Glu Gln Ala Gln 
    50                  55                  60                  


Ile Pro Glu Leu Pro Thr Ser Val Val Leu Asp Ile Gly Arg Leu Val 
65                  70                  75                  80  


Pro Ala Lys Arg Leu Val Gly Leu His His His Glu Pro Val Thr Lys 
                85                  90                  95      


Arg Asp Pro Ala Asp Ala Ile Val Val Leu Leu Arg His Leu Leu Gly 
            100                 105                 110         


Gln Gly Glu Ile Arg Lys Gly Ile Val Glu Gly Arg Asn Thr Glu Arg 
        115                 120                 125             


Ala Val Arg Ala Phe Ala Pro Phe His Gln Ala Leu His Val Leu Leu 
    130                 135                 140                 


Arg Ala Ala His Asp Val Leu Asn Glu Ile Gly Ser Pro Arg Glu Asp 
145                 150                 155                 160 


Arg Arg Arg Ala Ser Gln Glu Ile Val Ser Ala Asp His Glu Arg Asp 
                165                 170                 175     


Asp Leu Gly Leu Leu Asp Asp Thr Gly Arg Glu Val Leu Lys Arg Phe 
            180                 185                 190         


Glu Gln Leu Pro Arg Arg Pro Pro Arg Leu Arg Leu Asp Met Gln Arg 
        195                 200                 205             


Arg Ala Asp Leu Ala Gly Glu Ala Gly Ala Lys Ala Leu Arg Lys Ala 
    210                 215                 220                 


Leu Leu Arg Arg Thr Arg Thr Val Ala Ile Cys Asn Gly Val Ala Glu 
225                 230                 235                 240 


Arg Glu His Gln His Asp His Arg Leu Leu Gly Glu Ser Leu Ile Val 
                245                 250                 255     


Ser Tyr Gly Leu Ser Arg Arg Leu Val Thr Arg Gly Ala His Ala Pro 
            260                 265                 270         


Val Ala Arg Ser His Arg Arg Cys Gly Arg Cys Lys His Cys Arg Gln 
        275                 280                 285             


Asn His Lys Gly Gly Trp Pro Met Arg Ser Phe Trp Lys Arg Leu Arg 
    290                 295                 300                 


Ala Gly Val Ala Ala Leu Thr Ala Ala Cys Val Cys Ala Val Ser Cys 
305                 310                 315                 320 


Met Ser Leu Gln Ala Gly Ser Val Arg Ala Ala Asp Thr Lys Ala Gln 
                325                 330                 335     


Ala Pro Lys Ala Val Tyr Lys Val Asp Thr Lys Glu Lys Val Val Ala 
            340                 345                 350         


Leu Thr Phe Asp Ile Ser Trp Gly His Arg Thr Pro Glu Pro Val Leu 
        355                 360                 365             


Glu Thr Leu Lys Lys Cys Gly Val Thr Lys Ala Thr Phe Phe Leu Ser 
    370                 375                 380                 


Gly Pro Trp Thr Met His His Pro Glu Ile Ala Lys Lys Ile Lys Ala 
385                 390                 395                 400 


Met Gly Tyr Glu Ile Gly Ser His Gly Tyr Leu His Lys Asp Tyr Ser 
                405                 410                 415     


Asn Tyr Pro Asp Ser Trp Ile Arg Glu Gln Ala Met Leu Ala Asp Lys 
            420                 425                 430         


Ala Ile Gln Gln Val Thr Gly Val Lys Pro Lys Leu Phe Arg Thr Pro 
        435                 440                 445             


Asn Gly Asp Leu Asn Leu Arg Val Ile Arg Cys Leu Thr Ser Met Gly 
    450                 455                 460                 


Tyr Thr Val Val Gln Trp Asn Thr Asp Ser Leu Asp Trp Lys Asn Pro 
465                 470                 475                 480 


Gly Val Asp Ala Ile Val Asn Arg Val Thr Lys Arg Val Val Pro Gly 
                485                 490                 495     


Asp Ile Val Leu Met His Ala Ser Asp Ser Ser Lys Gln Ile Val Glu 
            500                 505                 510         


Ala Leu Pro Arg Ile Val Glu Asn Leu Arg Gln Gln Gly Tyr Arg Phe 
        515                 520                 525             


Val Thr Val Ser Glu Leu Leu Ala Gly Ala Asn Val Gln Ser Lys Val 
    530                 535                 540                 


Gln 
545 


<210>  451
<211>  545
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:439 and encoded by SEQ ID NO:446

<400>  451

Met Phe Pro Thr Arg Gly Pro Asp Ser Arg Gln Leu Leu Pro Thr Ala 
1               5                   10                  15      


Arg Ser Arg Pro Pro Arg Ser Pro Pro Ala Arg Gly Pro Arg Ala Leu 
            20                  25                  30          


Leu Arg Ser Arg Pro Leu Gln Arg Ala Lys Lys Arg Leu Arg Glu Arg 
        35                  40                  45              


Leu Val Ser Leu Val Arg Arg Met Asn Arg Ile Ala Glu Gln Ala Gln 
    50                  55                  60                  


Ile Pro Glu Leu Pro Thr Ser Val Val Leu Asp Ile Gly Arg Leu Val 
65                  70                  75                  80  


Pro Ala Lys Arg Leu Val Gly Leu His His His Glu Pro Val Thr Lys 
                85                  90                  95      


Arg Asp Pro Ala Asp Ala Ile Val Val Leu Leu Arg His Leu Leu Gly 
            100                 105                 110         


Gln Gly Glu Ile Arg Lys Gly Ile Val Glu Gly Arg Asn Thr Glu Arg 
        115                 120                 125             


Ala Val Arg Ala Phe Ala Pro Phe His Gln Ala Leu His Val Leu Leu 
    130                 135                 140                 


Arg Ala Ala His Asp Val Leu Asn Glu Ile Gly Ser Pro Arg Glu Asp 
145                 150                 155                 160 


Arg Arg Arg Ala Ser Gln Glu Ile Val Ser Ala Asp His Glu Arg Asp 
                165                 170                 175     


Asp Leu Gly Leu Leu Asp Asp Thr Gly Arg Glu Val Leu Lys Arg Phe 
            180                 185                 190         


Glu Gln Leu Pro Arg Arg Pro Pro Arg Leu Arg Leu Asp Met Gln Arg 
        195                 200                 205             


Arg Ala Asp Leu Ala Gly Glu Ala Gly Ala Lys Ala Leu Arg Lys Ala 
    210                 215                 220                 


Leu Leu Arg Arg Thr Arg Thr Val Ala Ile Cys Asn Gly Val Ala Glu 
225                 230                 235                 240 


Arg Glu His Gln His Asp His Arg Leu Leu Gly Glu Ser Leu Ile Val 
                245                 250                 255     


Ser Tyr Gly Leu Ser Arg Arg Leu Val Thr Arg Gly Ala His Ala Pro 
            260                 265                 270         


Val Ala Arg Ser His Arg Arg Cys Gly Arg Cys Lys His Cys Arg Gln 
        275                 280                 285             


Asn His Lys Gly Gly Trp Pro Met Arg Ser Phe Trp Lys Arg Leu Arg 
    290                 295                 300                 


Ala Gly Val Ala Ala Leu Thr Ala Ala Cys Val Cys Ala Val Ser Cys 
305                 310                 315                 320 


Met Ser Leu Gln Ala Gly Ser Val Arg Ala Ala Asp Thr Lys Ala Gln 
                325                 330                 335     


Ala Pro Lys Ala Val Tyr Lys Val Asp Thr Lys Glu Lys Val Val Ala 
            340                 345                 350         


Leu Thr Phe Asp Ile Ser Trp Gly His Arg Thr Pro Glu Pro Val Leu 
        355                 360                 365             


Glu Thr Leu Lys Lys Cys Gly Val Thr Lys Ala Thr Phe Phe Leu Ser 
    370                 375                 380                 


Gly Pro Trp Thr Met His His Pro Glu Ile Ala Lys Lys Ile Lys Ala 
385                 390                 395                 400 


Met Gly Tyr Glu Ile Gly Ser His Gly Tyr Leu His Lys Asp Tyr Ser 
                405                 410                 415     


Asn Tyr Pro Asp Ser Trp Ile Arg Glu Gln Ala Met Leu Ala Asp Lys 
            420                 425                 430         


Ala Ile Gln Gln Val Thr Gly Val Lys Pro Lys Leu Phe Arg Thr Pro 
        435                 440                 445             


Asn Gly Asp Leu Asn Leu Arg Val Ile Arg Cys Leu Thr Ser Met Gly 
    450                 455                 460                 


Tyr Thr Val Val Gln Trp Asn Thr Asp Ser Leu Asp Trp Lys Asn Pro 
465                 470                 475                 480 


Gly Val Asp Ala Ile Val Asn Arg Val Thr Lys Arg Val Val Pro Gly 
                485                 490                 495     


Asp Ile Val Leu Met His Ala Ser Asp Ser Ser Lys Gln Ile Val Glu 
            500                 505                 510         


Ala Leu Pro Arg Ile Val Glu Asn Leu Arg Gln Gln Gly Tyr Arg Phe 
        515                 520                 525             


Val Thr Val Ser Glu Leu Leu Ala Gly Ala Asn Val Gln Ser Lys Val 
    530                 535                 540                 


Gln 
545 


<210>  452
<211>  545
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:439 and encoded by SEQ ID NO:447

<400>  452

Met Phe Pro Thr Arg Gly Pro Glu Ser Lys Gln Leu Leu Pro Thr Ala 
1               5                   10                  15      


Arg Ser Arg Pro Pro Arg Ser Pro Pro Ala Arg Gly Pro Arg Ala Leu 
            20                  25                  30          


Leu Arg Ser Arg Pro Leu Gln Arg Ala Lys Lys Arg Leu Arg Glu Arg 
        35                  40                  45              


Leu Val Ser Leu Val Arg Arg Met Asn Arg Ile Ala Glu Gln Ala Gln 
    50                  55                  60                  


Ile Pro Glu Leu Pro Thr Ser Val Val Leu Asp Ile Gly Arg Leu Val 
65                  70                  75                  80  


Pro Ala Lys Arg Leu Val Gly Leu His His His Glu Pro Val Thr Lys 
                85                  90                  95      


Arg Asp Pro Ala Asp Ala Ile Val Val Leu Leu Arg His Leu Leu Gly 
            100                 105                 110         


Gln Gly Glu Ile Arg Lys Gly Ile Val Glu Gly Arg Asn Thr Glu Arg 
        115                 120                 125             


Ala Val Arg Ala Phe Ala Pro Phe His Gln Ala Leu His Val Leu Leu 
    130                 135                 140                 


Arg Ala Ala His Asp Val Leu Asn Glu Ile Gly Ser Pro Arg Glu Asp 
145                 150                 155                 160 


Arg Arg Arg Ala Ser Gln Glu Ile Val Ser Ala Asp His Glu Arg Asp 
                165                 170                 175     


Asp Leu Gly Leu Leu Asp Asp Thr Gly Arg Glu Val Leu Lys Arg Phe 
            180                 185                 190         


Glu Gln Leu Pro Arg Arg Pro Pro Arg Leu Arg Leu Asp Met Gln Arg 
        195                 200                 205             


Arg Ala Asp Leu Ala Gly Glu Ala Gly Ala Lys Ala Leu Arg Lys Ala 
    210                 215                 220                 


Leu Leu Arg Arg Thr Arg Thr Val Ala Ile Cys Asn Gly Val Ala Glu 
225                 230                 235                 240 


Arg Glu His Gln His Asp His Arg Leu Leu Gly Glu Ser Leu Ile Val 
                245                 250                 255     


Ser Tyr Gly Leu Ser Arg Arg Leu Val Thr Arg Gly Ala His Ala Pro 
            260                 265                 270         


Val Ala Arg Ser His Arg Arg Cys Gly Arg Cys Lys His Cys Arg Gln 
        275                 280                 285             


Asn His Lys Gly Gly Trp Pro Met Arg Ser Phe Trp Lys Arg Leu Arg 
    290                 295                 300                 


Ala Gly Val Ala Ala Leu Thr Ala Ala Cys Val Cys Ala Val Ser Cys 
305                 310                 315                 320 


Met Ser Leu Gln Ala Gly Ser Val Arg Ala Ala Asp Thr Lys Ala Gln 
                325                 330                 335     


Ala Pro Lys Ala Val Tyr Lys Val Asp Thr Lys Glu Lys Val Val Ala 
            340                 345                 350         


Leu Thr Phe Asp Ile Ser Trp Gly His Arg Thr Pro Glu Pro Val Leu 
        355                 360                 365             


Glu Thr Leu Lys Lys Cys Gly Val Thr Lys Ala Thr Phe Phe Leu Ser 
    370                 375                 380                 


Gly Pro Trp Thr Met His His Pro Glu Ile Ala Lys Lys Ile Lys Ala 
385                 390                 395                 400 


Met Gly Tyr Glu Ile Gly Ser His Gly Tyr Leu His Lys Asp Tyr Ser 
                405                 410                 415     


Asn Tyr Pro Asp Ser Trp Ile Arg Glu Gln Ala Met Leu Ala Asp Lys 
            420                 425                 430         


Ala Ile Gln Gln Val Thr Gly Val Lys Pro Lys Leu Phe Arg Thr Pro 
        435                 440                 445             


Asn Gly Asp Leu Asn Leu Arg Val Ile Arg Cys Leu Thr Ser Met Gly 
    450                 455                 460                 


Tyr Thr Val Val Gln Trp Asn Thr Asp Ser Leu Asp Trp Lys Asn Pro 
465                 470                 475                 480 


Gly Val Asp Ala Ile Val Asn Arg Val Thr Lys Arg Val Val Pro Gly 
                485                 490                 495     


Asp Ile Val Leu Met His Ala Ser Asp Ser Ser Lys Gln Ile Val Glu 
            500                 505                 510         


Ala Leu Pro Arg Ile Val Glu Asn Leu Arg Gln Gln Gly Tyr Arg Phe 
        515                 520                 525             


Val Thr Val Ser Glu Leu Leu Ala Gly Ala Asn Val Gln Ser Lys Val 
    530                 535                 540                 


Gln 
545 


<210>  453
<211>  545
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:439 and encoded by SEQ ID NO:448

<400>  453

Met Phe Pro Thr Arg Gly Pro Glu Ser Arg Gln Ile Leu Pro Thr Ala 
1               5                   10                  15      


Arg Ser Arg Pro Pro Arg Ser Pro Pro Ala Arg Gly Pro Arg Ala Leu 
            20                  25                  30          


Leu Arg Ser Arg Pro Leu Gln Arg Ala Lys Lys Arg Leu Arg Glu Arg 
        35                  40                  45              


Leu Val Ser Leu Val Arg Arg Met Asn Arg Ile Ala Glu Gln Ala Gln 
    50                  55                  60                  


Ile Pro Glu Leu Pro Thr Ser Val Val Leu Asp Ile Gly Arg Leu Val 
65                  70                  75                  80  


Pro Ala Lys Arg Leu Val Gly Leu His His His Glu Pro Val Thr Lys 
                85                  90                  95      


Arg Asp Pro Ala Asp Ala Ile Val Val Leu Leu Arg His Leu Leu Gly 
            100                 105                 110         


Gln Gly Glu Ile Arg Lys Gly Ile Val Glu Gly Arg Asn Thr Glu Arg 
        115                 120                 125             


Ala Val Arg Ala Phe Ala Pro Phe His Gln Ala Leu His Val Leu Leu 
    130                 135                 140                 


Arg Ala Ala His Asp Val Leu Asn Glu Ile Gly Ser Pro Arg Glu Asp 
145                 150                 155                 160 


Arg Arg Arg Ala Ser Gln Glu Ile Val Ser Ala Asp His Glu Arg Asp 
                165                 170                 175     


Asp Leu Gly Leu Leu Asp Asp Thr Gly Arg Glu Val Leu Lys Arg Phe 
            180                 185                 190         


Glu Gln Leu Pro Arg Arg Pro Pro Arg Leu Arg Leu Asp Met Gln Arg 
        195                 200                 205             


Arg Ala Asp Leu Ala Gly Glu Ala Gly Ala Lys Ala Leu Arg Lys Ala 
    210                 215                 220                 


Leu Leu Arg Arg Thr Arg Thr Val Ala Ile Cys Asn Gly Val Ala Glu 
225                 230                 235                 240 


Arg Glu His Gln His Asp His Arg Leu Leu Gly Glu Ser Leu Ile Val 
                245                 250                 255     


Ser Tyr Gly Leu Ser Arg Arg Leu Val Thr Arg Gly Ala His Ala Pro 
            260                 265                 270         


Val Ala Arg Ser His Arg Arg Cys Gly Arg Cys Lys His Cys Arg Gln 
        275                 280                 285             


Asn His Lys Gly Gly Trp Pro Met Arg Ser Phe Trp Lys Arg Leu Arg 
    290                 295                 300                 


Ala Gly Val Ala Ala Leu Thr Ala Ala Cys Val Cys Ala Val Ser Cys 
305                 310                 315                 320 


Met Ser Leu Gln Ala Gly Ser Val Arg Ala Ala Asp Thr Lys Ala Gln 
                325                 330                 335     


Ala Pro Lys Ala Val Tyr Lys Val Asp Thr Lys Glu Lys Val Val Ala 
            340                 345                 350         


Leu Thr Phe Asp Ile Ser Trp Gly His Arg Thr Pro Glu Pro Val Leu 
        355                 360                 365             


Glu Thr Leu Lys Lys Cys Gly Val Thr Lys Ala Thr Phe Phe Leu Ser 
    370                 375                 380                 


Gly Pro Trp Thr Met His His Pro Glu Ile Ala Lys Lys Ile Lys Ala 
385                 390                 395                 400 


Met Gly Tyr Glu Ile Gly Ser His Gly Tyr Leu His Lys Asp Tyr Ser 
                405                 410                 415     


Asn Tyr Pro Asp Ser Trp Ile Arg Glu Gln Ala Met Leu Ala Asp Lys 
            420                 425                 430         


Ala Ile Gln Gln Val Thr Gly Val Lys Pro Lys Leu Phe Arg Thr Pro 
        435                 440                 445             


Asn Gly Asp Leu Asn Leu Arg Val Ile Arg Cys Leu Thr Ser Met Gly 
    450                 455                 460                 


Tyr Thr Val Val Gln Trp Asn Thr Asp Ser Leu Asp Trp Lys Asn Pro 
465                 470                 475                 480 


Gly Val Asp Ala Ile Val Asn Arg Val Thr Lys Arg Val Val Pro Gly 
                485                 490                 495     


Asp Ile Val Leu Met His Ala Ser Asp Ser Ser Lys Gln Ile Val Glu 
            500                 505                 510         


Ala Leu Pro Arg Ile Val Glu Asn Leu Arg Gln Gln Gly Tyr Arg Phe 
        515                 520                 525             


Val Thr Val Ser Glu Leu Leu Ala Gly Ala Asn Val Gln Ser Lys Val 
    530                 535                 540                 


Gln 
545 


<210>  454
<211>  545
<212>  PRT
<213>  Artificial

<220>
<223>  Substitution in Alicyclobacillus acidocaldarius SEQ ID NO:439 and encoded by SEQ ID NO:449

<400>  454

Met Phe Pro Thr Arg Gly Pro Glu Ser Arg Gln Val Leu Pro Thr Ala 
1               5                   10                  15      


Arg Ser Arg Pro Pro Arg Ser Pro Pro Ala Arg Gly Pro Arg Ala Leu 
            20                  25                  30          


Leu Arg Ser Arg Pro Leu Gln Arg Ala Lys Lys Arg Leu Arg Glu Arg 
        35                  40                  45              


Leu Val Ser Leu Val Arg Arg Met Asn Arg Ile Ala Glu Gln Ala Gln 
    50                  55                  60                  


Ile Pro Glu Leu Pro Thr Ser Val Val Leu Asp Ile Gly Arg Leu Val 
65                  70                  75                  80  


Pro Ala Lys Arg Leu Val Gly Leu His His His Glu Pro Val Thr Lys 
                85                  90                  95      


Arg Asp Pro Ala Asp Ala Ile Val Val Leu Leu Arg His Leu Leu Gly 
            100                 105                 110         


Gln Gly Glu Ile Arg Lys Gly Ile Val Glu Gly Arg Asn Thr Glu Arg 
        115                 120                 125             


Ala Val Arg Ala Phe Ala Pro Phe His Gln Ala Leu His Val Leu Leu 
    130                 135                 140                 


Arg Ala Ala His Asp Val Leu Asn Glu Ile Gly Ser Pro Arg Glu Asp 
145                 150                 155                 160 


Arg Arg Arg Ala Ser Gln Glu Ile Val Ser Ala Asp His Glu Arg Asp 
                165                 170                 175     


Asp Leu Gly Leu Leu Asp Asp Thr Gly Arg Glu Val Leu Lys Arg Phe 
            180                 185                 190         


Glu Gln Leu Pro Arg Arg Pro Pro Arg Leu Arg Leu Asp Met Gln Arg 
        195                 200                 205             


Arg Ala Asp Leu Ala Gly Glu Ala Gly Ala Lys Ala Leu Arg Lys Ala 
    210                 215                 220                 


Leu Leu Arg Arg Thr Arg Thr Val Ala Ile Cys Asn Gly Val Ala Glu 
225                 230                 235                 240 


Arg Glu His Gln His Asp His Arg Leu Leu Gly Glu Ser Leu Ile Val 
                245                 250                 255     


Ser Tyr Gly Leu Ser Arg Arg Leu Val Thr Arg Gly Ala His Ala Pro 
            260                 265                 270         


Val Ala Arg Ser His Arg Arg Cys Gly Arg Cys Lys His Cys Arg Gln 
        275                 280                 285             


Asn His Lys Gly Gly Trp Pro Met Arg Ser Phe Trp Lys Arg Leu Arg 
    290                 295                 300                 


Ala Gly Val Ala Ala Leu Thr Ala Ala Cys Val Cys Ala Val Ser Cys 
305                 310                 315                 320 


Met Ser Leu Gln Ala Gly Ser Val Arg Ala Ala Asp Thr Lys Ala Gln 
                325                 330                 335     


Ala Pro Lys Ala Val Tyr Lys Val Asp Thr Lys Glu Lys Val Val Ala 
            340                 345                 350         


Leu Thr Phe Asp Ile Ser Trp Gly His Arg Thr Pro Glu Pro Val Leu 
        355                 360                 365             


Glu Thr Leu Lys Lys Cys Gly Val Thr Lys Ala Thr Phe Phe Leu Ser 
    370                 375                 380                 


Gly Pro Trp Thr Met His His Pro Glu Ile Ala Lys Lys Ile Lys Ala 
385                 390                 395                 400 


Met Gly Tyr Glu Ile Gly Ser His Gly Tyr Leu His Lys Asp Tyr Ser 
                405                 410                 415     


Asn Tyr Pro Asp Ser Trp Ile Arg Glu Gln Ala Met Leu Ala Asp Lys 
            420                 425                 430         


Ala Ile Gln Gln Val Thr Gly Val Lys Pro Lys Leu Phe Arg Thr Pro 
        435                 440                 445             


Asn Gly Asp Leu Asn Leu Arg Val Ile Arg Cys Leu Thr Ser Met Gly 
    450                 455                 460                 


Tyr Thr Val Val Gln Trp Asn Thr Asp Ser Leu Asp Trp Lys Asn Pro 
465                 470                 475                 480 


Gly Val Asp Ala Ile Val Asn Arg Val Thr Lys Arg Val Val Pro Gly 
                485                 490                 495     


Asp Ile Val Leu Met His Ala Ser Asp Ser Ser Lys Gln Ile Val Glu 
            500                 505                 510         


Ala Leu Pro Arg Ile Val Glu Asn Leu Arg Gln Gln Gly Tyr Arg Phe 
        515                 520                 525             


Val Thr Val Ser Glu Leu Leu Ala Gly Ala Asn Val Gln Ser Lys Val 
    530                 535                 540                 


Gln 
545 


<210>  455
<211>  1743
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  455
ttggccatgg aacttgtgtg gcagcatcgt tgggcggcag acgcttaccc gcttgacttg     60

tcaaccatgg ttcttgtgtt gcgcgttgcg cgatgcacac ccgcacagcg ggtgcgggtg    120

cactttggag atcggtacga acctgacttt cagaattcaa gtgaggctcg aagatacgga    180

tcggacggaa catttgactg gtttacgtgt cgagttgccg caccgacgcg aagactgaag    240

tatgcatttg aagtgttatc ctcaactgga cgggctgtgt acctgggtga gggcgggctc    300

gcggatacat tggatgctgt ccagcccttt caatatccgt acattcatcc atctcgggtt    360

ctcgctgtcc cagattgggt ggggcatgcg gtggcttatc aaatatttcc tgatcggttt    420

gctgtgggtg aacaacagtt ggtacgtccg acggatccat gggacgcgcg tccaacccct    480

gatagtgtat ttggtgggaa cctgcgaggg attgtggaca aactcccgta tctgagcgat    540

ctcggcgtga acctgatgta cctcacgcct atcttccagg ctccatcgaa ccacaaatac    600

gacacgcagg actattttgc cgtagacccc gcattcggta ccttgggcga tctgcaattg    660

ctcgtacgag aagctcatcg cctcgggatt cgcgtggttc tcgacgcagt gttcaaccat    720

tcggggtttc aatttgcccc ctttcaggac gtcattgcgc gcggtacggc gtctccctat    780

tggtcttggt tcttcgtgca aggggaccgc gttgacgtcg aatccgtcaa ttatgagact    840

ttcgcaacgc gcctcagaca tatgccaaaa ctgaacttgg cagagcctgc tgccgaagaa    900

tactttctgc aagtggccaa acactatgtt ctcgagtgcg atatcgacgg atggcgtttt    960

gacgtcgcca acgaaatcga tccccacttt tggtcacggt tgcgatcaga actgcgcgcc   1020

ttgaaacctg atatcttgtt gataggagaa atatggcatg acagcctccc ttggctgatg   1080

ggcgatgcct tcgatggcgt gatgaattat ccgcttcgag agcttgtcat gcgctatgcc   1140

atggacgaat ccatagatga acctgctttc gcagaagcgt gggtacgcct ctatctgcag   1200

tacccgcgtc cggcatggcg cgcgatgtgg aatctgttgg gcagtcatga tactgaacgc   1260

gcgcttacgc gcgcacgcgg tcatgttccc tctgttgtgt tggcgtttgc aatgcttttc   1320

acgctacccg gaattcccat ggtgtattat ggggacgaga tcggcatgga aggtggaacc   1380

gatccggatt gccgtcgggg catgatctgg gacgcgaact tatggcagct tgatcttcgc   1440

gaagccgtgc ggcaactcgc atggctcaag cgaacccatc ccgcgcttgc aggagataca   1500

atggagattc gcgatgcgaa ctctggcgtg ctgcattatg tacggctaaa cggcacaggt   1560

ccgcatcttc acattgctgt ttgcaaacgt cgagacttcg gcgcggaagt ggactcccca   1620

ctattcgcgt gggatgtgcc atctcggaca tcgggcgagg aacgaaagat cctgatatgg   1680

gaatgcgatt caactgaggg gtgtgggcat gattcacgag cagacggatt tcacaaccag   1740

tga                                                                 1743


<210>  456
<211>  580
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  456

Met Ala Met Glu Leu Val Trp Gln His Arg Trp Ala Ala Asp Ala Tyr 
1               5                   10                  15      


Pro Leu Asp Leu Ser Thr Met Val Leu Val Leu Arg Val Ala Arg Cys 
            20                  25                  30          


Thr Pro Ala Gln Arg Val Arg Val His Phe Gly Asp Arg Tyr Glu Pro 
        35                  40                  45              


Asp Phe Gln Asn Ser Ser Glu Ala Arg Arg Tyr Gly Ser Asp Gly Thr 
    50                  55                  60                  


Phe Asp Trp Phe Thr Cys Arg Val Ala Ala Pro Thr Arg Arg Leu Lys 
65                  70                  75                  80  


Tyr Ala Phe Glu Val Leu Ser Ser Thr Gly Arg Ala Val Tyr Leu Gly 
                85                  90                  95      


Glu Gly Gly Leu Ala Asp Thr Leu Asp Ala Val Gln Pro Phe Gln Tyr 
            100                 105                 110         


Pro Tyr Ile His Pro Ser Arg Val Leu Ala Val Pro Asp Trp Val Gly 
        115                 120                 125             


His Ala Val Ala Tyr Gln Ile Phe Pro Asp Arg Phe Ala Val Gly Glu 
    130                 135                 140                 


Gln Gln Leu Val Arg Pro Thr Asp Pro Trp Asp Ala Arg Pro Thr Pro 
145                 150                 155                 160 


Asp Ser Val Phe Gly Gly Asn Leu Arg Gly Ile Val Asp Lys Leu Pro 
                165                 170                 175     


Tyr Leu Ser Asp Leu Gly Val Asn Leu Met Tyr Leu Thr Pro Ile Phe 
            180                 185                 190         


Gln Ala Pro Ser Asn His Lys Tyr Asp Thr Gln Asp Tyr Phe Ala Val 
        195                 200                 205             


Asp Pro Ala Phe Gly Thr Leu Gly Asp Leu Gln Leu Leu Val Arg Glu 
    210                 215                 220                 


Ala His Arg Leu Gly Ile Arg Val Val Leu Asp Ala Val Phe Asn His 
225                 230                 235                 240 


Ser Gly Phe Gln Phe Ala Pro Phe Gln Asp Val Ile Ala Arg Gly Thr 
                245                 250                 255     


Ala Ser Pro Tyr Trp Ser Trp Phe Phe Val Gln Gly Asp Arg Val Asp 
            260                 265                 270         


Val Glu Ser Val Asn Tyr Glu Thr Phe Ala Thr Arg Leu Arg His Met 
        275                 280                 285             


Pro Lys Leu Asn Leu Ala Glu Pro Ala Ala Glu Glu Tyr Phe Leu Gln 
    290                 295                 300                 


Val Ala Lys His Tyr Val Leu Glu Cys Asp Ile Asp Gly Trp Arg Phe 
305                 310                 315                 320 


Asp Val Ala Asn Glu Ile Asp Pro His Phe Trp Ser Arg Leu Arg Ser 
                325                 330                 335     


Glu Leu Arg Ala Leu Lys Pro Asp Ile Leu Leu Ile Gly Glu Ile Trp 
            340                 345                 350         


His Asp Ser Leu Pro Trp Leu Met Gly Asp Ala Phe Asp Gly Val Met 
        355                 360                 365             


Asn Tyr Pro Leu Arg Glu Leu Val Met Arg Tyr Ala Met Asp Glu Ser 
    370                 375                 380                 


Ile Asp Glu Pro Ala Phe Ala Glu Ala Trp Val Arg Leu Tyr Leu Gln 
385                 390                 395                 400 


Tyr Pro Arg Pro Ala Trp Arg Ala Met Trp Asn Leu Leu Gly Ser His 
                405                 410                 415     


Asp Thr Glu Arg Ala Leu Thr Arg Ala Arg Gly His Val Pro Ser Val 
            420                 425                 430         


Val Leu Ala Phe Ala Met Leu Phe Thr Leu Pro Gly Ile Pro Met Val 
        435                 440                 445             


Tyr Tyr Gly Asp Glu Ile Gly Met Glu Gly Gly Thr Asp Pro Asp Cys 
    450                 455                 460                 


Arg Arg Gly Met Ile Trp Asp Ala Asn Leu Trp Gln Leu Asp Leu Arg 
465                 470                 475                 480 


Glu Ala Val Arg Gln Leu Ala Trp Leu Lys Arg Thr His Pro Ala Leu 
                485                 490                 495     


Ala Gly Asp Thr Met Glu Ile Arg Asp Ala Asn Ser Gly Val Leu His 
            500                 505                 510         


Tyr Val Arg Leu Asn Gly Thr Gly Pro His Leu His Ile Ala Val Cys 
        515                 520                 525             


Lys Arg Arg Asp Phe Gly Ala Glu Val Asp Ser Pro Leu Phe Ala Trp 
    530                 535                 540                 


Asp Val Pro Ser Arg Thr Ser Gly Glu Glu Arg Lys Ile Leu Ile Trp 
545                 550                 555                 560 


Glu Cys Asp Ser Thr Glu Gly Cys Gly His Asp Ser Arg Ala Asp Gly 
                565                 570                 575     


Phe His Asn Gln 
            580 


<210>  457
<211>  3924
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  457
ttgcacaaga ggaggttgat gcacgtgaag tggacgggtg ccgcgagcct tgcgacgacc     60

atcgtcatgt ctgcagcgct tccgttcgcg gcgtttgaaa acacccgttc cgtcggcacg    120

gaacgcgttc tggcggcgac cgcggcggat agtactaacg cctcgccccc gaccggggcg    180

tccgcaggcg gtggcacagc aggagagacc tactcgaatg ccgtgcagat tgtgagcggc    240

aatggctttc gcgctggaaa cggggccacg gtcgtcctcg ctgtgaatgg actgaacttg    300

aacccctcga gtttcaaggt tgtggtatcg aatagcctca acggcgtgat cgacgtcaca    360

agtgattccg tgctaacggg gccgaattcg attgccttgc accttcctgc cggggatgac    420

gggcttggcg ccggtacgta cacggtcacc gtcgaaagtg gaggtgattc ggtctcgacg    480

ccttcaggac agggacttca ggtcatgcct tatacgacgg ccgacaccat tcagtgggat    540

ggaatctaca catccgatgg cgcgatgtac gtgtcagatc cgaatccctc ccctggacaa    600

gaggtgacga tcagccttcg agcgtacagc gggaacctga cgaaggtgat cctgaattgc    660

tgggacaccg cacaaaacaa gggtttccag gtcgagatgt ctccaggcag aacgtttgga    720

ccgtatcagc tctggtctgc cacgatcccc gcttcaaacg gcggaacgat ctattatcgc    780

tttgacatat acgatggcac cagttttgcg tgtctctcag gtgacggact gcacacgtct    840

gacgacatca acaacaattt cccgttgccc gtggggacgg tcacgctttc gacacttcag    900

gcgaatcccg gtgatacggt gacggtctcc gaccctgtag gtgacttcgc cggaagccag    960

gatcaaccca atcacacggt gatacggttt gtcaactcgt cgggcgaaac ggccgccaca   1020

gtcaatggga cgaacgcgag ctggaacagc gtgcagttca cagtcccaca gagccttcca   1080

aacggcttgt atcgcgtcga gatcgacacg gtcgccaagg acgcggatgg ggtggtcaat   1140

gtcgaattgg acaggagtgc ggagcttatt gtagggcctc tgcccgcgtg gatgcaagcg   1200

tatgcacatg attcgtttca ggcgttctac cgatcgcctt tcggagccgt gtccacagga   1260

acccccatca cgcttcgcct gcgggctccg ctcagcgtga agagtgcgac gcttcgcctc   1320

tggggggcag cggatcagtc aggcgagatc gacctgccga tgcagaagct ccaaatgtcg   1380

ggagacgagt tggcgcaaca aaccggcgtg caggacatca acgactacac gtggtggacg   1440

gtgaccatcc ctgcggcgga tgtgaccaca cccgggacga tgtggtatca gttcgtgacg   1500

gagacggaca ctggccaggt ggtctactac gatgacaatg gagctcagct tgaagggcct   1560

ggccaggttg ggttgtcttc cgacggaccg agctaccaga tcagcgtata cgaacgggga   1620

tttcagacgc cagattggct gaagcacgcc gtgatctacg aaatcatgcc ggatcggttc   1680

tacaatggca atatcgccac ggaggagaat ccgaatacgc aaaaggggat ttatgtaggg   1740

gccgatggaa cggagtcatt aggccccatc cagttccacg agaactggga ctcgccgccc   1800

tatgatccga atattcctcc gttatctgat cccaaaattg ccagtctgcg aggcaatggc   1860

caatggaaca ttgacttttt cggaggtgat ttgcagggca tcgaggataa gctggactac   1920

ctgaagagcc ttggagtcaa tacgctgtat ctgatgcccg tctttgaggc ggaatccaat   1980

cacaaatatg acacagccga ctatttcaag attgaccctg gatttggaac gcagcaggac   2040

tggctgaatc tcgtacaggc tgcgcacgcg aaggggttcc atatcattct cgacggggtg   2100

ttcgaagata ccggaagtga cagcgtatat ttcaacaagt tcgggaactt ccactccaac   2160

ggtgcgtggc aggcgtacct gaagaaccag ccgtcgctgt cgccctacta ctcgtggtac   2220

gtgtggacag ggaacacctc aaacccatac gattcgtggt ttcagatcga cacgctgcca   2280

cttacggaca cgtcgaaccc cgcctatcag cgattcgtgt atgggagcga caactcagtc   2340

gcgcgtgtgt ggatccggga aggtgcggac ggatggcgct tggactcggc cgacaacggg   2400

aatttcaaca cggcatggtg gggtggcttt cggcaggccg tgaaatcgat cgatcccaac   2460

gcagcgatca tcggcgagat ctgggacaat gcgacgaatg acaatggaac ggattggttg   2520

acgggatcga ccttcgacag tgtaatgaac taccagttcc ggaacgccgt gatcgacttc   2580

ttccgcggca cgtacaacga cggaaacgtg cagcaccacg ccgtcgacgc tgcgggattc   2640

aaccaggaac tgatgcgcct gtacagtgaa tatcctctgc agtcgttcta ctcgatgatg   2700

aaccttgtcg attcgcaaga caccatgcgg atcctgacca tcttggagaa cgcgccgcag   2760

ccaggcgatc tatccgcgct ccagcaggat gagtacaggc cgtctcctgc ggctgaacag   2820

ttggggatcg agaggctgaa gcttgtatcg gactttcaat tcagcttccc gggcgatccg   2880

accatcttct acggcgacga ggcagggctc actggttatt cggatcccct caatcgtcgg   2940

acctatccgt gggacaacca gaatctcgat ctcctgaacc actaccgcaa gctcggggcc   3000

attcgaaacg ccaatcctgt gcttcagacg ggggatttca cgccgttgta cgcacagggc   3060

atggtgtacg catttgcaag gaccattcgg aatgggcgag atgtcttcgg tgtgccagcg   3120

gaggatgcca cggccattgt ggcgatcaac aatcagaacc aagctatcac cgtgaccatt   3180

ccgacggatg ggacggttgc ggacgggtcc acgatgctcg atgaactgaa caaccagtgg   3240

tacaaggtgc agaatggtgg cattacactc acgctgcaat cgtatcaagg tgccattttg   3300

gtgacgccga gcgacgcgcc gatggcttat ctgcaagagg aggattctca gaacgagatt   3360

gcgtggacgc ctgtgcaagg tgccatcggt tatcgcgtct ggagacagaa tccgaatgga   3420

caatgggtgc cctttggacc tgtgcttcct gccacggact tgagtgtcac ggtggaacgc   3480

gatgcatatg cgcaaacgtt tgctgtacaa gcgctgtttt cggcgtctga tcacgcccag   3540

tctccggtgt cggcacctaa gacggtatcg cttcccgtcg atgtgcccgc ggtacgcctg   3600

agtcagccga tcgttagtgg tcgtgtggtt ggagatcgtg cgatggtctc gatcacgccg   3660

gtttcaggcg cgacgcagta tgtgatctac cagagacagg gcgacggatc gtatgctccg   3720

gtcgcgacgg tctccacaag tggcgattcc gcagctatag gggaagttcc tgcgcaaggt   3780

ccggccaact cgcctcacgc gacgattcgc gtgacagtgc ccgtacctgc aggtttctcg   3840

tcggtgacct accgcgtggc tgcgcaaaac gaagatgggc aagctgtgac caatccattg   3900

accctatcgc tctcgaaaaa gtga                                          3924


<210>  458
<211>  1307
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  458

Met His Lys Arg Arg Leu Met His Val Lys Trp Thr Gly Ala Ala Ser 
1               5                   10                  15      


Leu Ala Thr Thr Ile Val Met Ser Ala Ala Leu Pro Phe Ala Ala Phe 
            20                  25                  30          


Glu Asn Thr Arg Ser Val Gly Thr Glu Arg Val Leu Ala Ala Thr Ala 
        35                  40                  45              


Ala Asp Ser Thr Asn Ala Ser Pro Pro Thr Gly Ala Ser Ala Gly Gly 
    50                  55                  60                  


Gly Thr Ala Gly Glu Thr Tyr Ser Asn Ala Val Gln Ile Val Ser Gly 
65                  70                  75                  80  


Asn Gly Phe Arg Ala Gly Asn Gly Ala Thr Val Val Leu Ala Val Asn 
                85                  90                  95      


Gly Leu Asn Leu Asn Pro Ser Ser Phe Lys Val Val Val Ser Asn Ser 
            100                 105                 110         


Leu Asn Gly Val Ile Asp Val Thr Ser Asp Ser Val Leu Thr Gly Pro 
        115                 120                 125             


Asn Ser Ile Ala Leu His Leu Pro Ala Gly Asp Asp Gly Leu Gly Ala 
    130                 135                 140                 


Gly Thr Tyr Thr Val Thr Val Glu Ser Gly Gly Asp Ser Val Ser Thr 
145                 150                 155                 160 


Pro Ser Gly Gln Gly Leu Gln Val Met Pro Tyr Thr Thr Ala Asp Thr 
                165                 170                 175     


Ile Gln Trp Asp Gly Ile Tyr Thr Ser Asp Gly Ala Met Tyr Val Ser 
            180                 185                 190         


Asp Pro Asn Pro Ser Pro Gly Gln Glu Val Thr Ile Ser Leu Arg Ala 
        195                 200                 205             


Tyr Ser Gly Asn Leu Thr Lys Val Ile Leu Asn Cys Trp Asp Thr Ala 
    210                 215                 220                 


Gln Asn Lys Gly Phe Gln Val Glu Met Ser Pro Gly Arg Thr Phe Gly 
225                 230                 235                 240 


Pro Tyr Gln Leu Trp Ser Ala Thr Ile Pro Ala Ser Asn Gly Gly Thr 
                245                 250                 255     


Ile Tyr Tyr Arg Phe Asp Ile Tyr Asp Gly Thr Ser Phe Ala Cys Leu 
            260                 265                 270         


Ser Gly Asp Gly Leu His Thr Ser Asp Asp Ile Asn Asn Asn Phe Pro 
        275                 280                 285             


Leu Pro Val Gly Thr Val Thr Leu Ser Thr Leu Gln Ala Asn Pro Gly 
    290                 295                 300                 


Asp Thr Val Thr Val Ser Asp Pro Val Gly Asp Phe Ala Gly Ser Gln 
305                 310                 315                 320 


Asp Gln Pro Asn His Thr Val Ile Arg Phe Val Asn Ser Ser Gly Glu 
                325                 330                 335     


Thr Ala Ala Thr Val Asn Gly Thr Asn Ala Ser Trp Asn Ser Val Gln 
            340                 345                 350         


Phe Thr Val Pro Gln Ser Leu Pro Asn Gly Leu Tyr Arg Val Glu Ile 
        355                 360                 365             


Asp Thr Val Ala Lys Asp Ala Asp Gly Val Val Asn Val Glu Leu Asp 
    370                 375                 380                 


Arg Ser Ala Glu Leu Ile Val Gly Pro Leu Pro Ala Trp Met Gln Ala 
385                 390                 395                 400 


Tyr Ala His Asp Ser Phe Gln Ala Phe Tyr Arg Ser Pro Phe Gly Ala 
                405                 410                 415     


Val Ser Thr Gly Thr Pro Ile Thr Leu Arg Leu Arg Ala Pro Leu Ser 
            420                 425                 430         


Val Lys Ser Ala Thr Leu Arg Leu Trp Gly Ala Ala Asp Gln Ser Gly 
        435                 440                 445             


Glu Ile Asp Leu Pro Met Gln Lys Leu Gln Met Ser Gly Asp Glu Leu 
    450                 455                 460                 


Ala Gln Gln Thr Gly Val Gln Asp Ile Asn Asp Tyr Thr Trp Trp Thr 
465                 470                 475                 480 


Val Thr Ile Pro Ala Ala Asp Val Thr Thr Pro Gly Thr Met Trp Tyr 
                485                 490                 495     


Gln Phe Val Thr Glu Thr Asp Thr Gly Gln Val Val Tyr Tyr Asp Asp 
            500                 505                 510         


Asn Gly Ala Gln Leu Glu Gly Pro Gly Gln Val Gly Leu Ser Ser Asp 
        515                 520                 525             


Gly Pro Ser Tyr Gln Ile Ser Val Tyr Glu Arg Gly Phe Gln Thr Pro 
    530                 535                 540                 


Asp Trp Leu Lys His Ala Val Ile Tyr Glu Ile Met Pro Asp Arg Phe 
545                 550                 555                 560 


Tyr Asn Gly Asn Ile Ala Thr Glu Glu Asn Pro Asn Thr Gln Lys Gly 
                565                 570                 575     


Ile Tyr Val Gly Ala Asp Gly Thr Glu Ser Leu Gly Pro Ile Gln Phe 
            580                 585                 590         


His Glu Asn Trp Asp Ser Pro Pro Tyr Asp Pro Asn Ile Pro Pro Leu 
        595                 600                 605             


Ser Asp Pro Lys Ile Ala Ser Leu Arg Gly Asn Gly Gln Trp Asn Ile 
    610                 615                 620                 


Asp Phe Phe Gly Gly Asp Leu Gln Gly Ile Glu Asp Lys Leu Asp Tyr 
625                 630                 635                 640 


Leu Lys Ser Leu Gly Val Asn Thr Leu Tyr Leu Met Pro Val Phe Glu 
                645                 650                 655     


Ala Glu Ser Asn His Lys Tyr Asp Thr Ala Asp Tyr Phe Lys Ile Asp 
            660                 665                 670         


Pro Gly Phe Gly Thr Gln Gln Asp Trp Leu Asn Leu Val Gln Ala Ala 
        675                 680                 685             


His Ala Lys Gly Phe His Ile Ile Leu Asp Gly Val Phe Glu Asp Thr 
    690                 695                 700                 


Gly Ser Asp Ser Val Tyr Phe Asn Lys Phe Gly Asn Phe His Ser Asn 
705                 710                 715                 720 


Gly Ala Trp Gln Ala Tyr Leu Lys Asn Gln Pro Ser Leu Ser Pro Tyr 
                725                 730                 735     


Tyr Ser Trp Tyr Val Trp Thr Gly Asn Thr Ser Asn Pro Tyr Asp Ser 
            740                 745                 750         


Trp Phe Gln Ile Asp Thr Leu Pro Leu Thr Asp Thr Ser Asn Pro Ala 
        755                 760                 765             


Tyr Gln Arg Phe Val Tyr Gly Ser Asp Asn Ser Val Ala Arg Val Trp 
    770                 775                 780                 


Ile Arg Glu Gly Ala Asp Gly Trp Arg Leu Asp Ser Ala Asp Asn Gly 
785                 790                 795                 800 


Asn Phe Asn Thr Ala Trp Trp Gly Gly Phe Arg Gln Ala Val Lys Ser 
                805                 810                 815     


Ile Asp Pro Asn Ala Ala Ile Ile Gly Glu Ile Trp Asp Asn Ala Thr 
            820                 825                 830         


Asn Asp Asn Gly Thr Asp Trp Leu Thr Gly Ser Thr Phe Asp Ser Val 
        835                 840                 845             


Met Asn Tyr Gln Phe Arg Asn Ala Val Ile Asp Phe Phe Arg Gly Thr 
    850                 855                 860                 


Tyr Asn Asp Gly Asn Val Gln His His Ala Val Asp Ala Ala Gly Phe 
865                 870                 875                 880 


Asn Gln Glu Leu Met Arg Leu Tyr Ser Glu Tyr Pro Leu Gln Ser Phe 
                885                 890                 895     


Tyr Ser Met Met Asn Leu Val Asp Ser Gln Asp Thr Met Arg Ile Leu 
            900                 905                 910         


Thr Ile Leu Glu Asn Ala Pro Gln Pro Gly Asp Leu Ser Ala Leu Gln 
        915                 920                 925             


Gln Asp Glu Tyr Arg Pro Ser Pro Ala Ala Glu Gln Leu Gly Ile Glu 
    930                 935                 940                 


Arg Leu Lys Leu Val Ser Asp Phe Gln Phe Ser Phe Pro Gly Asp Pro 
945                 950                 955                 960 


Thr Ile Phe Tyr Gly Asp Glu Ala Gly Leu Thr Gly Tyr Ser Asp Pro 
                965                 970                 975     


Leu Asn Arg Arg Thr Tyr Pro Trp Asp Asn Gln Asn Leu Asp Leu Leu 
            980                 985                 990         


Asn His Tyr Arg Lys Leu Gly Ala  Ile Arg Asn Ala Asn  Pro Val Leu 
        995                 1000                 1005             


Gln Thr  Gly Asp Phe Thr Pro  Leu Tyr Ala Gln Gly  Met Val Tyr 
    1010                 1015                 1020             


Ala Phe  Ala Arg Thr Ile Arg  Asn Gly Arg Asp Val  Phe Gly Val 
    1025                 1030                 1035             


Pro Ala  Glu Asp Ala Thr Ala  Ile Val Ala Ile Asn  Asn Gln Asn 
    1040                 1045                 1050             


Gln Ala  Ile Thr Val Thr Ile  Pro Thr Asp Gly Thr  Val Ala Asp 
    1055                 1060                 1065             


Gly Ser  Thr Met Leu Asp Glu  Leu Asn Asn Gln Trp  Tyr Lys Val 
    1070                 1075                 1080             


Gln Asn  Gly Gly Ile Thr Leu  Thr Leu Gln Ser Tyr  Gln Gly Ala 
    1085                 1090                 1095             


Ile Leu  Val Thr Pro Ser Asp  Ala Pro Met Ala Tyr  Leu Gln Glu 
    1100                 1105                 1110             


Glu Asp  Ser Gln Asn Glu Ile  Ala Trp Thr Pro Val  Gln Gly Ala 
    1115                 1120                 1125             


Ile Gly  Tyr Arg Val Trp Arg  Gln Asn Pro Asn Gly  Gln Trp Val 
    1130                 1135                 1140             


Pro Phe  Gly Pro Val Leu Pro  Ala Thr Asp Leu Ser  Val Thr Val 
    1145                 1150                 1155             


Glu Arg  Asp Ala Tyr Ala Gln  Thr Phe Ala Val Gln  Ala Leu Phe 
    1160                 1165                 1170             


Ser Ala  Ser Asp His Ala Gln  Ser Pro Val Ser Ala  Pro Lys Thr 
    1175                 1180                 1185             


Val Ser  Leu Pro Val Asp Val  Pro Ala Val Arg Leu  Ser Gln Pro 
    1190                 1195                 1200             


Ile Val  Ser Gly Arg Val Val  Gly Asp Arg Ala Met  Val Ser Ile 
    1205                 1210                 1215             


Thr Pro  Val Ser Gly Ala Thr  Gln Tyr Val Ile Tyr  Gln Arg Gln 
    1220                 1225                 1230             


Gly Asp  Gly Ser Tyr Ala Pro  Val Ala Thr Val Ser  Thr Ser Gly 
    1235                 1240                 1245             


Asp Ser  Ala Ala Ile Gly Glu  Val Pro Ala Gln Gly  Pro Ala Asn 
    1250                 1255                 1260             


Ser Pro  His Ala Thr Ile Arg  Val Thr Val Pro Val  Pro Ala Gly 
    1265                 1270                 1275             


Phe Ser  Ser Val Thr Tyr Arg  Val Ala Ala Gln Asn  Glu Asp Gly 
    1280                 1285                 1290             


Gln Ala  Val Thr Asn Pro Leu  Thr Leu Ser Leu Ser  Lys Lys 
    1295                 1300                 1305         


<210>  459
<211>  966
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  459
gtgagatgtc ccatcgcaga ggaggcgacc cacatgccgc tcgatcccgt cattcagcag     60

gtgctcgatc aactcaaccg catgcctgcc ccggactaca aacatctctc cgcccagcaa    120

tttcgttccc aacagtcgct gtttcctcct gtcaagaagg agcccgtggc cgaggtccga    180

gagtttgaca tggatctgcc tggccgcacg ctcaaggtgc gcatgtaccg cccggagggc    240

gtcgaaccgc cctaccccgc gctcgtgtat tatcacggcg gcggttgggt cgtcggagac    300

ctcgagacgc acgatcccgt ctgccgcgtc ctcgcgaaag acggccgcgc ggtcgtgttc    360

tccgtcgact accgcctggc gccggagcac aagttccctg ccgccgtgga agacgcctac    420

gacgcgcttc agtggatcgc ggagcgcgca gcggactttc atctcgatcc agcccgcatc    480

gcggtcggcg gagacagcgc cggagggaat cttgccgctg tgacgagcat ccttgccaaa    540

gagcgcggcg ggccggccat cgcgttccag ctgctcatct acccttccac ggggtacgat    600

ccggctcatc ctcccgcatc tatcgaagaa aatgcggaag gctatctcct gaccggcggc    660

atgatgctct ggttccggga tcaatacttg aacagcctgg aggaactcac gcatccgtgg    720

ttttcacccg tcctctaccc ggacttgagc ggcttgcctc cggcgtacat cgcgacggcg    780

cagtacgatc cgctgcgcga cgtcggcaag ctttacgcgg aagcgctgaa caaggcgggc    840

gtcaaggtcg agatcgagaa cttcgaagat ctgatccacg gattcgcaca gttttacagc    900

ctttcgcctg gcgcgacgaa ggcgctcgtc cgcattgcgg agaaacttcg agacgcgctg    960

gcctga                                                               966


<210>  460
<211>  321
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  460

Met Arg Cys Pro Ile Ala Glu Glu Ala Thr His Met Pro Leu Asp Pro 
1               5                   10                  15      


Val Ile Gln Gln Val Leu Asp Gln Leu Asn Arg Met Pro Ala Pro Asp 
            20                  25                  30          


Tyr Lys His Leu Ser Ala Gln Gln Phe Arg Ser Gln Gln Ser Leu Phe 
        35                  40                  45              


Pro Pro Val Lys Lys Glu Pro Val Ala Glu Val Arg Glu Phe Asp Met 
    50                  55                  60                  


Asp Leu Pro Gly Arg Thr Leu Lys Val Arg Met Tyr Arg Pro Glu Gly 
65                  70                  75                  80  


Val Glu Pro Pro Tyr Pro Ala Leu Val Tyr Tyr His Gly Gly Gly Trp 
                85                  90                  95      


Val Val Gly Asp Leu Glu Thr His Asp Pro Val Cys Arg Val Leu Ala 
            100                 105                 110         


Lys Asp Gly Arg Ala Val Val Phe Ser Val Asp Tyr Arg Leu Ala Pro 
        115                 120                 125             


Glu His Lys Phe Pro Ala Ala Val Glu Asp Ala Tyr Asp Ala Leu Gln 
    130                 135                 140                 


Trp Ile Ala Glu Arg Ala Ala Asp Phe His Leu Asp Pro Ala Arg Ile 
145                 150                 155                 160 


Ala Val Gly Gly Asp Ser Ala Gly Gly Asn Leu Ala Ala Val Thr Ser 
                165                 170                 175     


Ile Leu Ala Lys Glu Arg Gly Gly Pro Ala Ile Ala Phe Gln Leu Leu 
            180                 185                 190         


Ile Tyr Pro Ser Thr Gly Tyr Asp Pro Ala His Pro Pro Ala Ser Ile 
        195                 200                 205             


Glu Glu Asn Ala Glu Gly Tyr Leu Leu Thr Gly Gly Met Met Leu Trp 
    210                 215                 220                 


Phe Arg Asp Gln Tyr Leu Asn Ser Leu Glu Glu Leu Thr His Pro Trp 
225                 230                 235                 240 


Phe Ser Pro Val Leu Tyr Pro Asp Leu Ser Gly Leu Pro Pro Ala Tyr 
                245                 250                 255     


Ile Ala Thr Ala Gln Tyr Asp Pro Leu Arg Asp Val Gly Lys Leu Tyr 
            260                 265                 270         


Ala Glu Ala Leu Asn Lys Ala Gly Val Lys Val Glu Ile Glu Asn Phe 
        275                 280                 285             


Glu Asp Leu Ile His Gly Phe Ala Gln Phe Tyr Ser Leu Ser Pro Gly 
    290                 295                 300                 


Ala Thr Lys Ala Leu Val Arg Ile Ala Glu Lys Leu Arg Asp Ala Leu 
305                 310                 315                 320 


Ala 
    


<210>  461
<211>  963
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  461
atgggacgtt tcgaaagcgc attcgatctc ggcttcatcc gaggcatgac gtttggcttc     60

gtcggccagc acgggacgtg ggccaccgac gaggcgcgtg cgtcgatgcg ggcgctcgcc    120

gaacagccgt tcaactgggt gacgctcgcc ttcgcgggcc tgatggagca cccgggcgat    180

cccgccatcg cgtacgggcc gccagtcacc gtgagcgacg acgagatcgc gtcgatggtg    240

gatctcgccc acgacctcgg tctcaaagtg tgcctgaagc cgaccgtcaa ttgtcgagac    300

gggacgtgga gaggcgagat ccgcttcgag aaggaagacg gcccggacct cgagtcctgg    360

gcgacgtggt tccggtccta caccgacatg atggcccact acgcgcgcct ggcgaagcgc    420

acgggttgcg agatgttctg cgtcggctgc gagatgacga ccgccgagcc gcacgagggc    480

atgtggcgcg aggccatcgc gcgcgtgcgc agcgagtatg acggcctcgt gacgtacaac    540

tgcaaccacg ggcgcgagga gcacgtgcgg ttttgggacg cggtcgacct catctcgtcg    600

agcgcctact accccatcga ccggtggcga aatcgcgtgc cggtgctccg cgaggtcgca    660

gaggcgcagg ggaagccgct tttcttcatg gaggtggggt gtccgagccg ctccggttcc    720

ggcgcctgcc cgtgggacta tcggcacccg ggcgccatcg atctcgacga gcaggcgcgg    780

ttttacgaag ccatgttcgc cgccatgccc gacgagccgt ggttcaaggg ctatatgttg    840

tgggaatggc cttggaagct gtatccgcgc gaagcggcgt ccgaggacgg aagctactgc    900

atctatggca agccggcagc ggcggtcgtg gcgcgggtgt tctcggcgtt cgcggatgcg    960

taa                                                                  963


<210>  462
<211>  320
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  462

Met Gly Arg Phe Glu Ser Ala Phe Asp Leu Gly Phe Ile Arg Gly Met 
1               5                   10                  15      


Thr Phe Gly Phe Val Gly Gln His Gly Thr Trp Ala Thr Asp Glu Ala 
            20                  25                  30          


Arg Ala Ser Met Arg Ala Leu Ala Glu Gln Pro Phe Asn Trp Val Thr 
        35                  40                  45              


Leu Ala Phe Ala Gly Leu Met Glu His Pro Gly Asp Pro Ala Ile Ala 
    50                  55                  60                  


Tyr Gly Pro Pro Val Thr Val Ser Asp Asp Glu Ile Ala Ser Met Val 
65                  70                  75                  80  


Asp Leu Ala His Asp Leu Gly Leu Lys Val Cys Leu Lys Pro Thr Val 
                85                  90                  95      


Asn Cys Arg Asp Gly Thr Trp Arg Gly Glu Ile Arg Phe Glu Lys Glu 
            100                 105                 110         


Asp Gly Pro Asp Leu Glu Ser Trp Ala Thr Trp Phe Arg Ser Tyr Thr 
        115                 120                 125             


Asp Met Met Ala His Tyr Ala Arg Leu Ala Lys Arg Thr Gly Cys Glu 
    130                 135                 140                 


Met Phe Cys Val Gly Cys Glu Met Thr Thr Ala Glu Pro His Glu Gly 
145                 150                 155                 160 


Met Trp Arg Glu Ala Ile Ala Arg Val Arg Ser Glu Tyr Asp Gly Leu 
                165                 170                 175     


Val Thr Tyr Asn Cys Asn His Gly Arg Glu Glu His Val Arg Phe Trp 
            180                 185                 190         


Asp Ala Val Asp Leu Ile Ser Ser Ser Ala Tyr Tyr Pro Ile Asp Arg 
        195                 200                 205             


Trp Arg Asn Arg Val Pro Val Leu Arg Glu Val Ala Glu Ala Gln Gly 
    210                 215                 220                 


Lys Pro Leu Phe Phe Met Glu Val Gly Cys Pro Ser Arg Ser Gly Ser 
225                 230                 235                 240 


Gly Ala Cys Pro Trp Asp Tyr Arg His Pro Gly Ala Ile Asp Leu Asp 
                245                 250                 255     


Glu Gln Ala Arg Phe Tyr Glu Ala Met Phe Ala Ala Met Pro Asp Glu 
            260                 265                 270         


Pro Trp Phe Lys Gly Tyr Met Leu Trp Glu Trp Pro Trp Lys Leu Tyr 
        275                 280                 285             


Pro Arg Glu Ala Ala Ser Glu Asp Gly Ser Tyr Cys Ile Tyr Gly Lys 
    290                 295                 300                 


Pro Ala Ala Ala Val Val Ala Arg Val Phe Ser Ala Phe Ala Asp Ala 
305                 310                 315                 320 


<210>  463
<211>  1371
<212>  DNA
<213>  Alicyclobacillus acidocaldarius

<400>  463
atgagggaga tgcgcaaatt tccagaggga ttcgtgtggg ggactgcgac ggcatcgtat     60

caggttgaag gggccgcccg cgagggcggg cgcggacgat cgatttggga cacgttttcc    120

cacacgcctg gaaaggttgc cgagggccac accggggacg tcgcctgcga tcactatcac    180

cgctatcaag acgacgtgcg cctcatgaaa gagttaggaa tttcgtcgta ccgattttcc    240

atcgcatggc ctcgcgtgat gccagaaaag gggcgcgtct gggtgaaggg cctcgatttc    300

tacaagcggc tcgccacgga gctcctcgag agcggtattc gcccggccgt caccatgtat    360

cactgggacc ttccacagtg gatggaggac gaaggcggct ggaacagtcg agaaaccgtt    420

tcccgcttcc tcgagtacag cgagatcctg ttccgcgaac tcggcgatct cgtccccatg    480

tggatcaccc acaacgagcc gtggtgcgct tccattttag ggtacggcat cggcgtacac    540

gcgccgggcc tgaaggactg gcgccgcgcg taccgcgccg cgcaccatct gcttttgtcg    600

cacggccagg cggtccgcct gtaccgggag ctcggcttgc ccggcgagat cggcattacg    660

ctgaacctca cgccggttta tgcggccacg ccgaacccag aggatttggc cgcggccgac    720

aggcaggaca tgttccaaaa ccggtggttc ctcgatcccg tcctgagagg ggaatatcca    780

gaggaactct tgcaccgcgt ggatcaagtg gtaggtgggt ttgacgccgt caagcctggg    840

gatctggacg tgatcgccac acccatcgac tttctgggcg tgaactacta cacgcgcgct    900

gtggtcgccg acgatccgtc cgatccgctg ctcggggttc gccacctgcc cggcgaaggt    960

ccccgcaccg agatggactg ggaggtctat cccgacggct tgtacgatct gctcagccgc   1020

ctgcgccggg actacggcga catccccatc tacatcacgg agaacggcgc cgccttcgac   1080

gatcgcgtcc aggatggggg cgtccacgac gcagaccgag tggcgtatct cgcgtcccac   1140

ttcgctgcgg cgcatcggtt cctcgaggaa ggcggcaacc tgcggggcta ttacgtgtgg   1200

tcgctgatgg acaactttga gtgggcgttc ggctacacca agcgattcgg acttgtgtac   1260

gtggattacg atacgctcgc tcgcatcccg aaggacagtt acttctggta tcagcgcgtg   1320

atccgcgagg gcgggcttgt gccggcggaa cccgcggaaa cggcgcgata a            1371


<210>  464
<211>  456
<212>  PRT
<213>  Alicyclobacillus acidocaldarius

<400>  464

Met Arg Glu Met Arg Lys Phe Pro Glu Gly Phe Val Trp Gly Thr Ala 
1               5                   10                  15      


Thr Ala Ser Tyr Gln Val Glu Gly Ala Ala Arg Glu Gly Gly Arg Gly 
            20                  25                  30          


Arg Ser Ile Trp Asp Thr Phe Ser His Thr Pro Gly Lys Val Ala Glu 
        35                  40                  45              


Gly His Thr Gly Asp Val Ala Cys Asp His Tyr His Arg Tyr Gln Asp 
    50                  55                  60                  


Asp Val Arg Leu Met Lys Glu Leu Gly Ile Ser Ser Tyr Arg Phe Ser 
65                  70                  75                  80  


Ile Ala Trp Pro Arg Val Met Pro Glu Lys Gly Arg Val Trp Val Lys 
                85                  90                  95      


Gly Leu Asp Phe Tyr Lys Arg Leu Ala Thr Glu Leu Leu Glu Ser Gly 
            100                 105                 110         


Ile Arg Pro Ala Val Thr Met Tyr His Trp Asp Leu Pro Gln Trp Met 
        115                 120                 125             


Glu Asp Glu Gly Gly Trp Asn Ser Arg Glu Thr Val Ser Arg Phe Leu 
    130                 135                 140                 


Glu Tyr Ser Glu Ile Leu Phe Arg Glu Leu Gly Asp Leu Val Pro Met 
145                 150                 155                 160 


Trp Ile Thr His Asn Glu Pro Trp Cys Ala Ser Ile Leu Gly Tyr Gly 
                165                 170                 175     


Ile Gly Val His Ala Pro Gly Leu Lys Asp Trp Arg Arg Ala Tyr Arg 
            180                 185                 190         


Ala Ala His His Leu Leu Leu Ser His Gly Gln Ala Val Arg Leu Tyr 
        195                 200                 205             


Arg Glu Leu Gly Leu Pro Gly Glu Ile Gly Ile Thr Leu Asn Leu Thr 
    210                 215                 220                 


Pro Val Tyr Ala Ala Thr Pro Asn Pro Glu Asp Leu Ala Ala Ala Asp 
225                 230                 235                 240 


Arg Gln Asp Met Phe Gln Asn Arg Trp Phe Leu Asp Pro Val Leu Arg 
                245                 250                 255     


Gly Glu Tyr Pro Glu Glu Leu Leu His Arg Val Asp Gln Val Val Gly 
            260                 265                 270         


Gly Phe Asp Ala Val Lys Pro Gly Asp Leu Asp Val Ile Ala Thr Pro 
        275                 280                 285             


Ile Asp Phe Leu Gly Val Asn Tyr Tyr Thr Arg Ala Val Val Ala Asp 
    290                 295                 300                 


Asp Pro Ser Asp Pro Leu Leu Gly Val Arg His Leu Pro Gly Glu Gly 
305                 310                 315                 320 


Pro Arg Thr Glu Met Asp Trp Glu Val Tyr Pro Asp Gly Leu Tyr Asp 
                325                 330                 335     


Leu Leu Ser Arg Leu Arg Arg Asp Tyr Gly Asp Ile Pro Ile Tyr Ile 
            340                 345                 350         


Thr Glu Asn Gly Ala Ala Phe Asp Asp Arg Val Gln Asp Gly Gly Val 
        355                 360                 365             


His Asp Ala Asp Arg Val Ala Tyr Leu Ala Ser His Phe Ala Ala Ala 
    370                 375                 380                 


His Arg Phe Leu Glu Glu Gly Gly Asn Leu Arg Gly Tyr Tyr Val Trp 
385                 390                 395                 400 


Ser Leu Met Asp Asn Phe Glu Trp Ala Phe Gly Tyr Thr Lys Arg Phe 
                405                 410                 415     


Gly Leu Val Tyr Val Asp Tyr Asp Thr Leu Ala Arg Ile Pro Lys Asp 
            420                 425                 430         


Ser Tyr Phe Trp Tyr Gln Arg Val Ile Arg Glu Gly Gly Leu Val Pro 
        435                 440                 445             


Ala Glu Pro Ala Glu Thr Ala Arg 
    450                 455     


