                         SEQUENCE LISTING

<110>  The Trustees of the University of Pennsylvania
       Lupschutz, Joshua H.
       Bennett, Jean
       Chung, Daniel C.
 
<120>  Method of Treating Kidney Damage

<130>  UPN-W5312PCT

<150>  US 61/247,746
<151>  2009-10-01

<160>  2     

<170>  PatentIn version 3.5

<210>  1
<211>  8522
<212>  DNA
<213>  Homo sapiens

<400>  1
acttccggcg tatgaggcgg tgacaatggg agcagcgcgg gcggcgccgg gaggcagctg       60

acaagcgttt gcggcttcgc ttcatggccg ctctcccgcc cctcctggga tctgtgggga      120

gctggggagc ccgcagcggc ccggagccgg agctggcgag ccgagcggag acctgtgcgc      180

cgcgcctctg aggcgcagca tgtgaagcgg agacggcatc cagtgggggg cgagcctctc      240

agccggccgg gatggctacc acggccgagc tcttcgagga gccttttgtg gcagatgaat      300

atattgaacg tcttgtatgg agaaccccag gaggaggctc tagaggtgga cctgaagctt      360

ttgatcctaa aagattatta gaagaatttg taaatcatat tcaggaactc cagataatgg      420

atgaaaggat tcagaggaaa gtagagaaac tagagcaaca atgtcagaaa gaagccaagg      480

aatttgccaa gaaggtacaa gagctgcaga aaagcaatca ggttgccttc caacatttcc      540

aagaactaga tgagcacatt agctatgtag caactaaagt ctgtcacctt ggagaccagt      600

tagagggggt aaacacaccc agacaacggg cagtggaggc tcagaaattg atgaaatact      660

ttaatgagtt tctagatgga gaattgaaat ctgatgtttt tacaaattct gaaaagataa      720

aggaagcagc agacatcatt cagaagttgc acctaattgc ccaagagtta ccttttgata      780

gattttcaga agttaaatcc aaaattgcaa gtaaatacca tgatttagaa tgccagctga      840

ttcaggagtt taccagtgct caaagaagag gtgaaatctc cagaatgaga gaagtagcag      900

cagttttact tcattttaag ggttattccc attgtgttga tgtttatata aagcagtgcc      960

aggagggtgc ttatttgaga aatgatatat ttgaagacgc tggaatactc tgtcaaagag     1020

tgaacaaaca agttggagat atcttcagta atccagaaac agtcctggct aaacttattc     1080

aaaatgtatt tgaaatcaaa ctacagagtt ttgtgaaaga gcagttagaa gaatgtagga     1140

agtccgatgc agagcaatat ctcaaaaatc tctatgatct gtatacaaga accaccaatc     1200

tttccagcaa gctgatggag tttaatttag gtactgataa acagactttc ttgtctaagc     1260

ttatcaaatc cattttcatt tcctatttgg agaactatat tgaggtggag actggatatt     1320

tgaaaagcag aagtgctatg atcctacagc gctattatga ttcgaaaaac catcaaaaga     1380

gatccattgg cacaggaggt attcaagatt tgaaggaaag aattagacag cgtaccaact     1440

taccacttgg gccaagtatc gatactcatg gggagacttt tctatcccaa gaagtggtgg     1500

ttaatctttt acaagaaacc aaacaagcct ttgaaagatg tcataggctc tctgatcctt     1560

ctgacttacc aaggaatgcc ttcagaattt ttaccattct tgtggaattt ttatgtattg     1620

agcatattga ttatgctttg gaaacaggac ttgctggaat tccctcttca gattctagga     1680

atgcaaatct ttattttttg gacgttgtgc aacaggccaa tactattttt catctttttg     1740

acaaacagtt taatgatcac cttatgccac taataagctc ttctcctaag ttatctgaat     1800

gccttcagaa gaaaaaagaa ataattgaac aaatggagat gaaattggat actggcattg     1860

ataggacatt aaattgtatg attggacaga tgaagcatat tttggctgca gaacagaaga     1920

aaacagattt taagccagaa gatgaaaaca atgttttgat tcaatatact aatgcctgtg     1980

taaaagtctg tgcttacgta agaaaacaag tggagaagat taaaaattcc atggatggga     2040

agaatgtgga tacagttttg atggaacttg gagtacgttt tcatcgactt atctatgagc     2100

atcttcaaca atattcctac agttgtatgg gtggcatgtt ggccatttgt gatgtagccg     2160

aatataggaa gtgtgccaaa gacttcaaga ttccaatggt attacatctt tttgatactc     2220

tgcatgctct ttgcaatctt ctggtagttg ccccagataa tttaaagcaa gtctgctcag     2280

gagaacaact tgctaatctg gacaagaata tacttcactc cttcgtacaa cttcgtgctg     2340

attatagatc tgcccgcctt gctcgacact tcagctgaga ttgaatttac aaaggaattc     2400

agtgtcagtt cctttacaga ggaatgtctt atacttcagc agccctcggt tgatagaaag     2460

cacaggagat accttatgac acagccaaca ttttgtgaaa caatgactgg aacaaaacag     2520

cagccatact tacctttgag gttttattta aagtttggat accactagct atattttgct     2580

tttttcccct cacattgaat tttaattcca ttcttgaatg tagaaatttc agattctcta     2640

aaactacatg tcactgtttt tatcctagaa aatgttgctg tcagaaggca aaggaaatgt     2700

taccagtgtt ttcggttctt gtacttttaa catattccat ttagaaattt tgccattctg     2760

ttttccatta ataataggtg aaatacagga aaactacatt tgttattcct cagtttttaa     2820

tgaccttttc agcatcaatt gttaatcaga ttattttagg ttttcgtaaa taattttttt     2880

gcctctttca aaaggttaac aattaagcat actttctgca gttggttgat tggatttttt     2940

tctgaggtac agcattaata ctagtccaaa aaatgtcata aactgaacta aaatgatgaa     3000

ctattttatg tagacattag gagtggatcg gaatacttct gctttctggg taaaacttaa     3060

aagtttacta tttcttattt ggtaaataga ttttaagcca attctagtaa gaaattaata     3120

aaactacctt attttgtatt tcacttaagg tggaggacct taactaaagg accatattta     3180

ttcattattt taatattata agggaagtaa aaaaaagtga ggtatagtct aaatggtgca     3240

tataggaaat actgacagtg tttagcaaca tgcagccctt tgagatttct gtcgtaatgc     3300

taaacttgaa taagatggaa tggctgaaca tgtggttagt cttttatttt aagaagaatt     3360

gagaattgat agatttggag atgagctttg caaaggctgt ttgcttttca tgtctatagg     3420

tctgtcattg tcctttttca aagcatttct gaagttattc ctacttggat atagttaatg     3480

gaattggctt aatttgatga cataataaat cacttataaa attttaaata tcaagtgaaa     3540

atttagaaag gccattacta ttctataaac cttataaact tgctctggga gaatgcattc     3600

taaattatat atagtgtttc agctcccatt gtggtgttca tagtcttcta ggaacagata     3660

aacttaagta ttcaattcac tcttggcatt ttttctttaa tataggcttt ttagcctatt     3720

tttggaaaac tgcttttctt ctgagaacct tattctgaat gtcatcaact ttaccaaacc     3780

ttctaagtcc agagctaact tagtactgtt taagttacta ttgactgaat tttcttcatt     3840

ttctgtttag tccagtgtta ccaaggtaag ctggggaatg aagtatacca acttctttca     3900

gagcatttta ggacattatg gcagctttag aaggctgtct tgtttctagc caagggagag     3960

ccagcgcagg ttttggatac tagagaaagt catttgcttg tactattgcc attttagaaa     4020

gctctgatgt gaattcaaat tttacctctg ttacttaaag ccaacaattt taaggcagta     4080

gttttactgg ccatttaagc tctttgtaca gtgtcaattt gtaaaaaaga aaaaacgaaa     4140

aaaaatctca aataaaacat gagataacat tttaagactt ccaaatcaga gaagtgcttc     4200

aaattatttt gtttggatta atttttaaaa tgtaaagcat atacttgttg cttagttatt     4260

ttgtttatta ttttcatgtt tgagttctgt gcaatatttt ctattatgtc cgttgatagg     4320

acagtgacaa aattcgtaag tgaatactta atttaaaagt gttaacatta atgctcaata     4380

aacaaattcc ctgcagttgt tttttttatt tcactctttt tatattttag agccatccat     4440

cctgaatttt ataaatgatt ttttatttaa aaatttgaga tttttaaaat ttttcacagc     4500

acaggtcttc tcattttctt ttttagcaaa aaatacttga ctatataaac aagactagaa     4560

atttatccta aacagatggt ctttctctga gggaaaaaaa aaaatgtgtc atgtgaggca     4620

atatgcattc tttgtattct gattttttaa gtgttttcat atttatagcc atcacaaaat     4680

tttgcccaaa gtgtatggct cagaagagat gatcaataac taaaatgttt ttcgttttgc     4740

acatggtaaa attttaggta gagagtggag ctttgtataa ttggtaactt taaccaacat     4800

ttacgtaagt acggtctttg cagtattaca caataccgca tgagctaata tgcagtattt     4860

aggtaatgca ttgaatgaag ttgaaaatat gctcttaaca cactgtgcat tgtttttcta     4920

aaattgagaa atatctgaaa tacagaatac gaatttaata aaggaagcct accttatgta     4980

aattatgatg ttgaaaatga cagtcaacca gagtagatga agtgtcctta tgaagaatta     5040

ttaaatagta gctggatgga tctttagatg gatgaccacc tgaccattcc aggacaattt     5100

ttggtcccat tttgaggatt gccatagttg caagtcctta ggatcttcct tgttttaaaa     5160

aactatcaaa gtaggttaaa ttaaaatcta atttaaatta ggttaattta tattacattg     5220

tagatcattc ttttttcccc cctctttcac ttctaaatat tttgctttct aaatactagc     5280

cttctggttc acagtgaaat aatttaatta tcaatcagta gattgattcc aagtggagaa     5340

ttcactgctt ccctaaaatg cgtttttctt acctgtaatg gtgaatattt acaaggatct     5400

ggataaagag attttgattt ttgaaatgcc acaaaacccc ttaaagtggt caagtaccta     5460

aggtagtggc taaggcatgc ttgaactgtg tttgagagac agcagttcag tcagtacata     5520

atttgttggt gactaacaaa gctcacatct gggagattaa ctttttttaa cgcaaaaata     5580

ttctgcacat tacccatata ttgttgaatt ttacatacaa agcattttgt gctttcattc     5640

aattagttta actatattca gtttctgtat tatttctctc tgatctatcc tgtaattatt     5700

ctatacttta gaagaaaaga tcagttcata ttgttagact gaataattct acatgaagtt     5760

aaaagttagc aatttaaaaa attttgctgc ataataaaga taattatagt tacatgtatt     5820

gatttaagtc tcacacactg tgctaataag tcctttgcac atattattgg attctagagc     5880

aaccctagga tttgggtact attatttcca tttgacagat gaaaaaccta atgcatagaa     5940

agataagtag accagtcaag gtctacagct agtaaaatgc tcagattgaa acctaaatct     6000

tttctcactc acttttaggt tctatatgct attctcctta cgtaacgtta aatagatcct     6060

ttagtttgat aggttcatta gttttgctta atcgttgctt ccaatatgat tcttattgta     6120

gtatttatat tacaaagttg gcatacaggg tcaatatcta atttactgtt gtgtttttct     6180

taatatgttc aatgtatggt catacttttt aaatttgatt ttttaaatat tataagtggt     6240

catgaaattt taatgttaag tttgtaccta atagaaatat gtctatcaca aatctttatt     6300

ggtattattt tatatacttt tccagcttga taattttcac aatagaaaga gaccaaatat     6360

tttgtactat attttgtgac atagaagtaa atgacaactc taccttggaa gatatgaaga     6420

aatcagtgtt tttatgttca aaaactattt taaatgtcat aggcttgcca attgtgttaa     6480

ctatttagta cattggtagt ttttaaatga ctaatgctgg agtgaaaatg taaggcaaaa     6540

tatttagtat attaacagta gatagtcatt ttcatgtaat cagaattgca tgttaagggt     6600

tttaaaagct gtcataactc ttacctttta tttctaccag tgatcaatca tttctcttta     6660

caaatttagg gaggaaacaa ctgttcaaat gtatagggga cagaaacctg acatttagag     6720

aacagaaatt ttaattgcca aattaaagca gctaggctgc ccctgggctt aacaaaattc     6780

ctatttttga actagacccg aggtatttta tcattattat ttgataggta ccattaacct     6840

ttgttttgtg attatcgact tttgggggga aagatgagta attaaacaca ctcgcccatt     6900

ttctaagtgg tttagaaggt tgcagtctgc ctcaccatac aaagccagtt taaataggaa     6960

tatatcacat catacttcac atagcagtca acctcagagg aaagtcattt attcagaagg     7020

catagatttt gctagacagc agtgatgcat tacaaatata taattatttg cactaatatt     7080

tgagcaggtg gaatggatta gaacatggtc aacatcatgc tgctgataac atgtattttt     7140

ctatattaat atgtactgtg caacatgtat taaaattgtc aataattcat tttagccaag     7200

atactaatat ttatattact gtgtttaaga gacagtatcc aactgagcca cttttaattt     7260

aaaagtctga aactggaatt aagtttactt tcaaaaatca cttaaattac tttataatca     7320

gtgaaaggtc agtaaaatgt agaattataa gtgcctagtg acttaatagg aggaaatatg     7380

gagggttaag gaaggaagta ggaacctgga ataagaaagc taagtttcat ttatagttcc     7440

aatgagtgac tttctttgtt ttcaccactg ggaatcttaa atgaagaaag tgtcgtatcc     7500

cttccagtta tctttatgtt aataaactaa gtgaagtttg gatagaacta acaaaggaat     7560

tagtctccat tggtggactt ccagagtttt gagattaaac tttgagaggt gagaagcctt     7620

cctgatgccc ctgtaatctt aaattggcag gtgcctctaa gtgaggccat ccctctttgc     7680

ctgcctatca ttttaatctt tatactgtaa ctggttcctt tcaactctgg ccttttattg     7740

tagcactttt atcaagtctg cagcttccca gctacttggg aggctgaggt gggaagaaca     7800

cttgaagcta ggagttcaag accactctgg gcaacatagt gagtccctgt ttttagaaaa     7860

ataaataacc tttaggtttt tgctatagaa aatatccaaa tagagtctgg acaatgctgg     7920

atgtaaagaa aactgtgaag ctacctctaa gcatattgtt tgtgaatact gtgtaccatt     7980

tagaggataa catgggggat tcacatgaag ttatgtgaaa atattttata aggaataata     8040

cctaagtgcc tctcttaagt tctccagtag aatgtatttt caatttttgc cacaaggggg     8100

agaagttatt tttatagtaa tatgtacatt tttttatttt aaaaatagaa ttcacacaac     8160

tttacagcat ctatgaacat tttgctatcc caattatgtg tgtgtgtgca tgtgtgtaaa     8220

caagattctg aaagtcttgc atgagaaaaa tttcaaagga aattaataac aaaaccaaaa     8280

cagttttgaa gaacatgtgc acagtggaca caggaattga acaaagttta ccatgattaa     8340

cattatgttt tcttagttat atatcacatt gaattccttt atcaactcta ataagaatct     8400

actgattagt gttctacatt ctgcttttta aagaaaaatt tttgaaacaa tcagacttaa     8460

cagaagggtt gtaaatactg tacaaataaa atttttccct tttgagaata aaaaaaaaaa     8520

aa                                                                    8522


<210>  2
<211>  708
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ala Thr Thr Ala Glu Leu Phe Glu Glu Pro Phe Val Ala Asp Glu 
1               5                   10                  15      


Tyr Ile Glu Arg Leu Val Trp Arg Thr Pro Gly Gly Gly Ser Arg Gly 
            20                  25                  30          


Gly Pro Glu Ala Phe Asp Pro Lys Arg Leu Leu Glu Glu Phe Val Asn 
        35                  40                  45              


His Ile Gln Glu Leu Gln Ile Met Asp Glu Arg Ile Gln Arg Lys Val 
    50                  55                  60                  


Glu Lys Leu Glu Gln Gln Cys Gln Lys Glu Ala Lys Glu Phe Ala Lys 
65                  70                  75                  80  


Lys Val Gln Glu Leu Gln Lys Ser Asn Gln Val Ala Phe Gln His Phe 
                85                  90                  95      


Gln Glu Leu Asp Glu His Ile Ser Tyr Val Ala Thr Lys Val Cys His 
            100                 105                 110         


Leu Gly Asp Gln Leu Glu Gly Val Asn Thr Pro Arg Gln Arg Ala Val 
        115                 120                 125             


Glu Ala Gln Lys Leu Met Lys Tyr Phe Asn Glu Phe Leu Asp Gly Glu 
    130                 135                 140                 


Leu Lys Ser Asp Val Phe Thr Asn Ser Glu Lys Ile Lys Glu Ala Ala 
145                 150                 155                 160 


Asp Ile Ile Gln Lys Leu His Leu Ile Ala Gln Glu Leu Pro Phe Asp 
                165                 170                 175     


Arg Phe Ser Glu Val Lys Ser Lys Ile Ala Ser Lys Tyr His Asp Leu 
            180                 185                 190         


Glu Cys Gln Leu Ile Gln Glu Phe Thr Ser Ala Gln Arg Arg Gly Glu 
        195                 200                 205             


Ile Ser Arg Met Arg Glu Val Ala Ala Val Leu Leu His Phe Lys Gly 
    210                 215                 220                 


Tyr Ser His Cys Val Asp Val Tyr Ile Lys Gln Cys Gln Glu Gly Ala 
225                 230                 235                 240 


Tyr Leu Arg Asn Asp Ile Phe Glu Asp Ala Gly Ile Leu Cys Gln Arg 
                245                 250                 255     


Val Asn Lys Gln Val Gly Asp Ile Phe Ser Asn Pro Glu Thr Val Leu 
            260                 265                 270         


Ala Lys Leu Ile Gln Asn Val Phe Glu Ile Lys Leu Gln Ser Phe Val 
        275                 280                 285             


Lys Glu Gln Leu Glu Glu Cys Arg Lys Ser Asp Ala Glu Gln Tyr Leu 
    290                 295                 300                 


Lys Asn Leu Tyr Asp Leu Tyr Thr Arg Thr Thr Asn Leu Ser Ser Lys 
305                 310                 315                 320 


Leu Met Glu Phe Asn Leu Gly Thr Asp Lys Gln Thr Phe Leu Ser Lys 
                325                 330                 335     


Leu Ile Lys Ser Ile Phe Ile Ser Tyr Leu Glu Asn Tyr Ile Glu Val 
            340                 345                 350         


Glu Thr Gly Tyr Leu Lys Ser Arg Ser Ala Met Ile Leu Gln Arg Tyr 
        355                 360                 365             


Tyr Asp Ser Lys Asn His Gln Lys Arg Ser Ile Gly Thr Gly Gly Ile 
    370                 375                 380                 


Gln Asp Leu Lys Glu Arg Ile Arg Gln Arg Thr Asn Leu Pro Leu Gly 
385                 390                 395                 400 


Pro Ser Ile Asp Thr His Gly Glu Thr Phe Leu Ser Gln Glu Val Val 
                405                 410                 415     


Val Asn Leu Leu Gln Glu Thr Lys Gln Ala Phe Glu Arg Cys His Arg 
            420                 425                 430         


Leu Ser Asp Pro Ser Asp Leu Pro Arg Asn Ala Phe Arg Ile Phe Thr 
        435                 440                 445             


Ile Leu Val Glu Phe Leu Cys Ile Glu His Ile Asp Tyr Ala Leu Glu 
    450                 455                 460                 


Thr Gly Leu Ala Gly Ile Pro Ser Ser Asp Ser Arg Asn Ala Asn Leu 
465                 470                 475                 480 


Tyr Phe Leu Asp Val Val Gln Gln Ala Asn Thr Ile Phe His Leu Phe 
                485                 490                 495     


Asp Lys Gln Phe Asn Asp His Leu Met Pro Leu Ile Ser Ser Ser Pro 
            500                 505                 510         


Lys Leu Ser Glu Cys Leu Gln Lys Lys Lys Glu Ile Ile Glu Gln Met 
        515                 520                 525             


Glu Met Lys Leu Asp Thr Gly Ile Asp Arg Thr Leu Asn Cys Met Ile 
    530                 535                 540                 


Gly Gln Met Lys His Ile Leu Ala Ala Glu Gln Lys Lys Thr Asp Phe 
545                 550                 555                 560 


Lys Pro Glu Asp Glu Asn Asn Val Leu Ile Gln Tyr Thr Asn Ala Cys 
                565                 570                 575     


Val Lys Val Cys Ala Tyr Val Arg Lys Gln Val Glu Lys Ile Lys Asn 
            580                 585                 590         


Ser Met Asp Gly Lys Asn Val Asp Thr Val Leu Met Glu Leu Gly Val 
        595                 600                 605             


Arg Phe His Arg Leu Ile Tyr Glu His Leu Gln Gln Tyr Ser Tyr Ser 
    610                 615                 620                 


Cys Met Gly Gly Met Leu Ala Ile Cys Asp Val Ala Glu Tyr Arg Lys 
625                 630                 635                 640 


Cys Ala Lys Asp Phe Lys Ile Pro Met Val Leu His Leu Phe Asp Thr 
                645                 650                 655     


Leu His Ala Leu Cys Asn Leu Leu Val Val Ala Pro Asp Asn Leu Lys 
            660                 665                 670         


Gln Val Cys Ser Gly Glu Gln Leu Ala Asn Leu Asp Lys Asn Ile Leu 
        675                 680                 685             


His Ser Phe Val Gln Leu Arg Ala Asp Tyr Arg Ser Ala Arg Leu Ala 
    690                 695                 700                 


Arg His Phe Ser 
705             


