                         SEQUENCE LISTING

<110>  DALMAU, Josep
 
<120>  GABA (B) RECEPTOR ANTIBODIES ASSOCIATE WITH ENCEPHALITIS, MEMORY 
       DEFICITS AND SEIZURES

<130>  P-73365-USP

<140>  US 09/999,999
<141>  2009-09-11

<160>  6     

<170>  PatentIn version 3.5

<210>  1
<211>  961
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
1               5                   10                  15      


Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
            20                  25                  30          


Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
        35                  40                  45              


Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
    50                  55                  60                  


Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
65                  70                  75                  80  


Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                85                  90                  95      


Val Arg Ile Cys Ser Lys Ser Tyr Leu Thr Leu Glu Asn Gly Lys Val 
            100                 105                 110         


Phe Leu Thr Gly Gly Asp Leu Pro Ala Leu Asp Gly Ala Arg Val Asp 
        115                 120                 125             


Phe Arg Cys Asp Pro Asp Phe His Leu Val Gly Ser Ser Arg Ser Ile 
    130                 135                 140                 


Cys Ser Gln Gly Gln Trp Ser Thr Pro Lys Pro His Cys Gln Val Asn 
145                 150                 155                 160 


Arg Thr Pro His Ser Glu Arg Arg Ala Val Tyr Ile Gly Ala Leu Phe 
                165                 170                 175     


Pro Met Ser Gly Gly Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val 
            180                 185                 190         


Glu Met Ala Leu Glu Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp 
        195                 200                 205             


Tyr Glu Leu Lys Leu Ile His His Asp Ser Lys Cys Asp Pro Gly Gln 
    210                 215                 220                 


Ala Thr Lys Tyr Leu Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile 
225                 230                 235                 240 


Ile Leu Met Pro Gly Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala 
                245                 250                 255     


Ala Arg Met Trp Asn Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro 
            260                 265                 270         


Ala Leu Ser Asn Arg Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro 
        275                 280                 285             


Ser Ala Thr Leu His Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp 
    290                 295                 300                 


Gly Trp Lys Lys Ile Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr 
305                 310                 315                 320 


Ser Thr Leu Asp Asp Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu 
                325                 330                 335     


Ile Thr Phe Arg Gln Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys 
            340                 345                 350         


Asn Leu Lys Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu 
        355                 360                 365             


Thr Glu Ala Arg Lys Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe 
    370                 375                 380                 


Gly Lys Lys Tyr Val Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp 
385                 390                 395                 400 


Phe Lys Ile Tyr Asp Pro Ser Ile Asn Cys Thr Val Asp Glu Met Thr 
                405                 410                 415     


Glu Ala Val Glu Gly His Ile Thr Thr Glu Ile Val Met Leu Asn Pro 
            420                 425                 430         


Ala Asn Thr Arg Ser Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu 
        435                 440                 445             


Lys Leu Thr Lys Arg Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe 
    450                 455                 460                 


Gln Glu Ala Pro Leu Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala 
465                 470                 475                 480 


Leu Asn Lys Thr Ser Gly Gly Gly Gly Arg Ser Gly Val Arg Leu Glu 
                485                 490                 495     


Asp Phe Asn Tyr Asn Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala 
            500                 505                 510         


Met Asn Ser Ser Ser Phe Glu Gly Val Ser Gly His Val Val Phe Asp 
        515                 520                 525             


Ala Ser Gly Ser Arg Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly 
    530                 535                 540                 


Gly Ser Tyr Lys Lys Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu 
545                 550                 555                 560 


Ser Trp Ser Lys Thr Asp Lys Trp Ile Gly Gly Ser Pro Pro Ala Asp 
                565                 570                 575     


Gln Thr Leu Val Ile Lys Thr Phe Arg Phe Leu Ser Gln Lys Leu Phe 
            580                 585                 590         


Ile Ser Val Ser Val Leu Ser Ser Leu Gly Ile Val Leu Ala Val Val 
        595                 600                 605             


Cys Leu Ser Phe Asn Ile Tyr Asn Ser His Val Arg Tyr Ile Gln Asn 
    610                 615                 620                 


Ser Gln Pro Asn Leu Asn Asn Leu Thr Ala Val Gly Cys Ser Leu Ala 
625                 630                 635                 640 


Leu Ala Ala Val Phe Pro Leu Gly Leu Asp Gly Tyr His Ile Gly Arg 
                645                 650                 655     


Asn Gln Phe Pro Phe Val Cys Gln Ala Arg Leu Trp Leu Leu Gly Leu 
            660                 665                 670         


Gly Phe Ser Leu Gly Tyr Gly Ser Met Phe Thr Lys Ile Trp Trp Val 
        675                 680                 685             


His Thr Val Phe Thr Lys Lys Glu Glu Lys Lys Glu Trp Arg Lys Thr 
    690                 695                 700                 


Leu Glu Pro Trp Lys Leu Tyr Ala Thr Val Gly Leu Leu Val Gly Met 
705                 710                 715                 720 


Asp Val Leu Thr Leu Ala Ile Trp Gln Ile Val Asp Pro Leu His Arg 
                725                 730                 735     


Thr Ile Glu Thr Phe Ala Lys Glu Glu Pro Lys Glu Asp Ile Asp Val 
            740                 745                 750         


Ser Ile Leu Pro Gln Leu Glu His Cys Ser Ser Arg Lys Met Asn Thr 
        755                 760                 765             


Trp Leu Gly Ile Phe Tyr Gly Tyr Lys Gly Leu Leu Leu Leu Leu Gly 
    770                 775                 780                 


Ile Phe Leu Ala Tyr Glu Thr Lys Ser Val Ser Thr Glu Lys Ile Asn 
785                 790                 795                 800 


Asp His Arg Ala Val Gly Met Ala Ile Tyr Asn Val Ala Val Leu Cys 
                805                 810                 815     


Leu Ile Thr Ala Pro Val Thr Met Ile Leu Ser Ser Gln Gln Asp Ala 
            820                 825                 830         


Ala Phe Ala Phe Ala Ser Leu Ala Ile Val Phe Ser Ser Tyr Ile Thr 
        835                 840                 845             


Leu Val Val Leu Phe Val Pro Lys Met Arg Arg Leu Ile Thr Arg Gly 
    850                 855                 860                 


Glu Trp Gln Ser Glu Ala Gln Asp Thr Met Lys Thr Gly Ser Ser Thr 
865                 870                 875                 880 


Asn Asn Asn Glu Glu Glu Lys Ser Arg Leu Leu Glu Lys Glu Asn Arg 
                885                 890                 895     


Glu Leu Glu Lys Ile Ile Ala Glu Lys Glu Glu Arg Val Ser Glu Leu 
            900                 905                 910         


Arg His Gln Leu Gln Ser Arg Gln Gln Leu Arg Ser Arg Arg His Pro 
        915                 920                 925             


Pro Thr Pro Pro Glu Pro Ser Gly Gly Leu Pro Arg Gly Pro Pro Glu 
    930                 935                 940                 


Pro Pro Asp Arg Leu Ser Cys Asp Gly Ser Arg Val His Leu Leu Tyr 
945                 950                 955                 960 


Lys 
    


<210>  2
<211>  844
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Pro Gly Ala Pro Phe Ala Arg Val Gly Trp Pro Leu Pro Leu 
1               5                   10                  15      


Leu Val Val Met Ala Ala Gly Val Ala Pro Val Trp Ala Ser His Ser 
            20                  25                  30          


Pro His Leu Pro Arg Pro His Ser Arg Val Pro Pro His Pro Ser Ser 
        35                  40                  45              


Glu Arg Arg Ala Val Tyr Ile Gly Ala Leu Phe Pro Met Ser Gly Gly 
    50                  55                  60                  


Trp Pro Gly Gly Gln Ala Cys Gln Pro Ala Val Glu Met Ala Leu Glu 
65                  70                  75                  80  


Asp Val Asn Ser Arg Arg Asp Ile Leu Pro Asp Tyr Glu Leu Lys Leu 
                85                  90                  95      


Ile His His Asp Ser Lys Cys Asp Pro Gly Gln Ala Thr Lys Tyr Leu 
            100                 105                 110         


Tyr Glu Leu Leu Tyr Asn Asp Pro Ile Lys Ile Ile Leu Met Pro Gly 
        115                 120                 125             


Cys Ser Ser Val Ser Thr Leu Val Ala Glu Ala Ala Arg Met Trp Asn 
    130                 135                 140                 


Leu Ile Val Leu Ser Tyr Gly Ser Ser Ser Pro Ala Leu Ser Asn Arg 
145                 150                 155                 160 


Gln Arg Phe Pro Thr Phe Phe Arg Thr His Pro Ser Ala Thr Leu His 
                165                 170                 175     


Asn Pro Thr Arg Val Lys Leu Phe Glu Lys Trp Gly Trp Lys Lys Ile 
            180                 185                 190         


Ala Thr Ile Gln Gln Thr Thr Glu Val Phe Thr Ser Thr Leu Asp Asp 
        195                 200                 205             


Leu Glu Glu Arg Val Lys Glu Ala Gly Ile Glu Ile Thr Phe Arg Gln 
    210                 215                 220                 


Ser Phe Phe Ser Asp Pro Ala Val Pro Val Lys Asn Leu Lys Arg Gln 
225                 230                 235                 240 


Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Glu Thr Glu Ala Arg Lys 
                245                 250                 255     


Val Phe Cys Glu Val Tyr Lys Glu Arg Leu Phe Gly Lys Lys Tyr Val 
            260                 265                 270         


Trp Phe Leu Ile Gly Trp Tyr Ala Asp Asn Trp Phe Lys Ile Tyr Asp 
        275                 280                 285             


Pro Ser Ile Asn Cys Thr Val Asp Glu Met Thr Glu Ala Val Glu Gly 
    290                 295                 300                 


His Ile Thr Thr Glu Ile Val Met Leu Asn Pro Ala Asn Thr Arg Ser 
305                 310                 315                 320 


Ile Ser Asn Met Thr Ser Gln Glu Phe Val Glu Lys Leu Thr Lys Arg 
                325                 330                 335     


Leu Lys Arg His Pro Glu Glu Thr Gly Gly Phe Gln Glu Ala Pro Leu 
            340                 345                 350         


Ala Tyr Asp Ala Ile Trp Ala Leu Ala Leu Ala Leu Asn Lys Thr Ser 
        355                 360                 365             


Gly Gly Gly Gly Arg Ser Gly Val Arg Leu Glu Asp Phe Asn Tyr Asn 
    370                 375                 380                 


Asn Gln Thr Ile Thr Asp Gln Ile Tyr Arg Ala Met Asn Ser Ser Ser 
385                 390                 395                 400 


Phe Glu Gly Val Ser Gly His Val Val Phe Asp Ala Ser Gly Ser Arg 
                405                 410                 415     


Met Ala Trp Thr Leu Ile Glu Gln Leu Gln Gly Gly Ser Tyr Lys Lys 
            420                 425                 430         


Ile Gly Tyr Tyr Asp Ser Thr Lys Asp Asp Leu Ser Trp Ser Lys Thr 
        435                 440                 445             


Asp Lys Trp Ile Gly Gly Ser Pro Pro Ala Asp Gln Thr Leu Val Ile 
    450                 455                 460                 


Lys Thr Phe Arg Phe Leu Ser Gln Lys Leu Phe Ile Ser Val Ser Val 
465                 470                 475                 480 


Leu Ser Ser Leu Gly Ile Val Leu Ala Val Val Cys Leu Ser Phe Asn 
                485                 490                 495     


Ile Tyr Asn Ser His Val Arg Tyr Ile Gln Asn Ser Gln Pro Asn Leu 
            500                 505                 510         


Asn Asn Leu Thr Ala Val Gly Cys Ser Leu Ala Leu Ala Ala Val Phe 
        515                 520                 525             


Pro Leu Gly Leu Asp Gly Tyr His Ile Gly Arg Asn Gln Phe Pro Phe 
    530                 535                 540                 


Val Cys Gln Ala Arg Leu Trp Leu Leu Gly Leu Gly Phe Ser Leu Gly 
545                 550                 555                 560 


Tyr Gly Ser Met Phe Thr Lys Ile Trp Trp Val His Thr Val Phe Thr 
                565                 570                 575     


Lys Lys Glu Glu Lys Lys Glu Trp Arg Lys Thr Leu Glu Pro Trp Lys 
            580                 585                 590         


Leu Tyr Ala Thr Val Gly Leu Leu Val Gly Met Asp Val Leu Thr Leu 
        595                 600                 605             


Ala Ile Trp Gln Ile Val Asp Pro Leu His Arg Thr Ile Glu Thr Phe 
    610                 615                 620                 


Ala Lys Glu Glu Pro Lys Glu Asp Ile Asp Val Ser Ile Leu Pro Gln 
625                 630                 635                 640 


Leu Glu His Cys Ser Ser Arg Lys Met Asn Thr Trp Leu Gly Ile Phe 
                645                 650                 655     


Tyr Gly Tyr Lys Gly Leu Leu Leu Leu Leu Gly Ile Phe Leu Ala Tyr 
            660                 665                 670         


Glu Thr Lys Ser Val Ser Thr Glu Lys Ile Asn Asp His Arg Ala Val 
        675                 680                 685             


Gly Met Ala Ile Tyr Asn Val Ala Val Leu Cys Leu Ile Thr Ala Pro 
    690                 695                 700                 


Val Thr Met Ile Leu Ser Ser Gln Gln Asp Ala Ala Phe Ala Phe Ala 
705                 710                 715                 720 


Ser Leu Ala Ile Val Phe Ser Ser Tyr Ile Thr Leu Val Val Leu Phe 
                725                 730                 735     


Val Pro Lys Met Arg Arg Leu Ile Thr Arg Gly Glu Trp Gln Ser Glu 
            740                 745                 750         


Ala Gln Asp Thr Met Lys Thr Gly Ser Ser Thr Asn Asn Asn Glu Glu 
        755                 760                 765             


Glu Lys Ser Arg Leu Leu Glu Lys Glu Asn Arg Glu Leu Glu Lys Ile 
    770                 775                 780                 


Ile Ala Glu Lys Glu Glu Arg Val Ser Glu Leu Arg His Gln Leu Gln 
785                 790                 795                 800 


Ser Arg Gln Gln Leu Arg Ser Arg Arg His Pro Pro Thr Pro Pro Glu 
                805                 810                 815     


Pro Ser Gly Gly Leu Pro Arg Gly Pro Pro Glu Pro Pro Asp Arg Leu 
            820                 825                 830         


Ser Cys Asp Gly Ser Arg Val His Leu Leu Tyr Lys 
        835                 840                 


<210>  3
<211>  899
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Leu Leu Leu Leu Leu Leu Ala Pro Leu Phe Leu Arg Pro Pro Gly 
1               5                   10                  15      


Ala Gly Gly Ala Gln Thr Pro Asn Ala Thr Ser Glu Gly Cys Gln Ile 
            20                  25                  30          


Ile His Pro Pro Trp Glu Gly Gly Ile Arg Tyr Arg Gly Leu Thr Arg 
        35                  40                  45              


Asp Gln Val Lys Ala Ile Asn Phe Leu Pro Val Asp Tyr Glu Ile Glu 
    50                  55                  60                  


Tyr Val Cys Arg Gly Glu Arg Glu Val Val Gly Pro Lys Val Arg Lys 
65                  70                  75                  80  


Cys Leu Ala Asn Gly Ser Trp Thr Asp Met Asp Thr Pro Ser Arg Cys 
                85                  90                  95      


Val Asn Arg Thr Pro His Ser Glu Arg Arg Ala Val Tyr Ile Gly Ala 
            100                 105                 110         


Leu Phe Pro Met Ser Gly Gly Trp Pro Gly Gly Gln Ala Cys Gln Pro 
        115                 120                 125             


Ala Val Glu Met Ala Leu Glu Asp Val Asn Ser Arg Arg Asp Ile Leu 
    130                 135                 140                 


Pro Asp Tyr Glu Leu Lys Leu Ile His His Asp Ser Lys Cys Asp Pro 
145                 150                 155                 160 


Gly Gln Ala Thr Lys Tyr Leu Tyr Glu Leu Leu Tyr Asn Asp Pro Ile 
                165                 170                 175     


Lys Ile Ile Leu Met Pro Gly Cys Ser Ser Val Ser Thr Leu Val Ala 
            180                 185                 190         


Glu Ala Ala Arg Met Trp Asn Leu Ile Val Leu Ser Tyr Gly Ser Ser 
        195                 200                 205             


Ser Pro Ala Leu Ser Asn Arg Gln Arg Phe Pro Thr Phe Phe Arg Thr 
    210                 215                 220                 


His Pro Ser Ala Thr Leu His Asn Pro Thr Arg Val Lys Leu Phe Glu 
225                 230                 235                 240 


Lys Trp Gly Trp Lys Lys Ile Ala Thr Ile Gln Gln Thr Thr Glu Val 
                245                 250                 255     


Phe Thr Ser Thr Leu Asp Asp Leu Glu Glu Arg Val Lys Glu Ala Gly 
            260                 265                 270         


Ile Glu Ile Thr Phe Arg Gln Ser Phe Phe Ser Asp Pro Ala Val Pro 
        275                 280                 285             


Val Lys Asn Leu Lys Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe 
    290                 295                 300                 


Tyr Glu Thr Glu Ala Arg Lys Val Phe Cys Glu Val Tyr Lys Glu Arg 
305                 310                 315                 320 


Leu Phe Gly Lys Lys Tyr Val Trp Phe Leu Ile Gly Trp Tyr Ala Asp 
                325                 330                 335     


Asn Trp Phe Lys Ile Tyr Asp Pro Ser Ile Asn Cys Thr Val Asp Glu 
            340                 345                 350         


Met Thr Glu Ala Val Glu Gly His Ile Thr Thr Glu Ile Val Met Leu 
        355                 360                 365             


Asn Pro Ala Asn Thr Arg Ser Ile Ser Asn Met Thr Ser Gln Glu Phe 
    370                 375                 380                 


Val Glu Lys Leu Thr Lys Arg Leu Lys Arg His Pro Glu Glu Thr Gly 
385                 390                 395                 400 


Gly Phe Gln Glu Ala Pro Leu Ala Tyr Asp Ala Ile Trp Ala Leu Ala 
                405                 410                 415     


Leu Ala Leu Asn Lys Thr Ser Gly Gly Gly Gly Arg Ser Gly Val Arg 
            420                 425                 430         


Leu Glu Asp Phe Asn Tyr Asn Asn Gln Thr Ile Thr Asp Gln Ile Tyr 
        435                 440                 445             


Arg Ala Met Asn Ser Ser Ser Phe Glu Gly Val Ser Gly His Val Val 
    450                 455                 460                 


Phe Asp Ala Ser Gly Ser Arg Met Ala Trp Thr Leu Ile Glu Gln Leu 
465                 470                 475                 480 


Gln Gly Gly Ser Tyr Lys Lys Ile Gly Tyr Tyr Asp Ser Thr Lys Asp 
                485                 490                 495     


Asp Leu Ser Trp Ser Lys Thr Asp Lys Trp Ile Gly Gly Ser Pro Pro 
            500                 505                 510         


Ala Asp Gln Thr Leu Val Ile Lys Thr Phe Arg Phe Leu Ser Gln Lys 
        515                 520                 525             


Leu Phe Ile Ser Val Ser Val Leu Ser Ser Leu Gly Ile Val Leu Ala 
    530                 535                 540                 


Val Val Cys Leu Ser Phe Asn Ile Tyr Asn Ser His Val Arg Tyr Ile 
545                 550                 555                 560 


Gln Asn Ser Gln Pro Asn Leu Asn Asn Leu Thr Ala Val Gly Cys Ser 
                565                 570                 575     


Leu Ala Leu Ala Ala Val Phe Pro Leu Gly Leu Asp Gly Tyr His Ile 
            580                 585                 590         


Gly Arg Asn Gln Phe Pro Phe Val Cys Gln Ala Arg Leu Trp Leu Leu 
        595                 600                 605             


Gly Leu Gly Phe Ser Leu Gly Tyr Gly Ser Met Phe Thr Lys Ile Trp 
    610                 615                 620                 


Trp Val His Thr Val Phe Thr Lys Lys Glu Glu Lys Lys Glu Trp Arg 
625                 630                 635                 640 


Lys Thr Leu Glu Pro Trp Lys Leu Tyr Ala Thr Val Gly Leu Leu Val 
                645                 650                 655     


Gly Met Asp Val Leu Thr Leu Ala Ile Trp Gln Ile Val Asp Pro Leu 
            660                 665                 670         


His Arg Thr Ile Glu Thr Phe Ala Lys Glu Glu Pro Lys Glu Asp Ile 
        675                 680                 685             


Asp Val Ser Ile Leu Pro Gln Leu Glu His Cys Ser Ser Arg Lys Met 
    690                 695                 700                 


Asn Thr Trp Leu Gly Ile Phe Tyr Gly Tyr Lys Gly Leu Leu Leu Leu 
705                 710                 715                 720 


Leu Gly Ile Phe Leu Ala Tyr Glu Thr Lys Ser Val Ser Thr Glu Lys 
                725                 730                 735     


Ile Asn Asp His Arg Ala Val Gly Met Ala Ile Tyr Asn Val Ala Val 
            740                 745                 750         


Leu Cys Leu Ile Thr Ala Pro Val Thr Met Ile Leu Ser Ser Gln Gln 
        755                 760                 765             


Asp Ala Ala Phe Ala Phe Ala Ser Leu Ala Ile Val Phe Ser Ser Tyr 
    770                 775                 780                 


Ile Thr Leu Val Val Leu Phe Val Pro Lys Met Arg Arg Leu Ile Thr 
785                 790                 795                 800 


Arg Gly Glu Trp Gln Ser Glu Ala Gln Asp Thr Met Lys Thr Gly Ser 
                805                 810                 815     


Ser Thr Asn Asn Asn Glu Glu Glu Lys Ser Arg Leu Leu Glu Lys Glu 
            820                 825                 830         


Asn Arg Glu Leu Glu Lys Ile Ile Ala Glu Lys Glu Glu Arg Val Ser 
        835                 840                 845             


Glu Leu Arg His Gln Leu Gln Ser Arg Gln Gln Leu Arg Ser Arg Arg 
    850                 855                 860                 


His Pro Pro Thr Pro Pro Glu Pro Ser Gly Gly Leu Pro Arg Gly Pro 
865                 870                 875                 880 


Pro Glu Pro Pro Asp Arg Leu Ser Cys Asp Gly Ser Arg Val His Leu 
                885                 890                 895     


Leu Tyr Lys 
            


<210>  4
<211>  4547
<212>  DNA
<213>  Homo sapiens

<400>  4
ccctctcttc cccccgccct gccttccctt gcaccctcct tcttccctcc gcccgggagc       60

tctccctggt ccccggcgcc gcctccttcc ctcccggctc cccgctcccc gctcccgtgg      120

ctgccgccgc cccggggaag aagagacagg ggtggggttt gggggaagcg agagaggagg      180

ggagagaccc tggccaggct ggagcctgga ttcgagggga ggagggacgg gaggaggaga      240

aaggtggagg agaagggagg ggggagcggg gaggagcggc cgggcctggg gccttgaggc      300

ccggggagag ccggggagcc gggcccgcgc gccgagatgt tgctgctgct gctactggcg      360

ccactcttcc tccgcccccc gggcgcgggc ggggcgcaga cccccaacgc cacctcagaa      420

ggttgccaga tcatacaccc gccctgggaa gggggcatca ggtaccgggg cctgactcgg      480

gaccaggtga aggctatcaa cttcctgcca gtggactatg agattgagta tgtgtgccgg      540

ggggagcgcg aggtggtggg gcccaaggtc cgcaagtgcc tggccaacgg ctcctggaca      600

gatatggaca cacccagccg ctgtgtccga atctgctcca agtcttattt gaccctggaa      660

aatgggaagg ttttcctgac gggtggggac ctcccagctc tggacggagc ccgggtggat      720

ttccggtgtg accccgactt ccatctggtg ggcagctccc ggagcatctg tagtcagggc      780

cagtggagca cccccaagcc ccactgccag gtgaatcgaa cgccacactc agaacggcgc      840

gcagtgtaca tcggggcact gtttcccatg agcgggggct ggccaggggg ccaggcctgc      900

cagcccgcgg tggagatggc gctggaggac gtgaatagcc gcagggacat cctgccggac      960

tatgagctca agctcatcca ccacgacagc aagtgtgatc caggccaagc caccaagtac     1020

ctatatgagc tgctctacaa cgaccctatc aagatcatcc ttatgcctgg ctgcagctct     1080

gtctccacgc tggtggctga ggctgctagg atgtggaacc tcattgtgct ttcctatggc     1140

tccagctcac cagccctgtc aaaccggcag cgtttcccca ctttcttccg aacgcaccca     1200

tcagccacac tccacaaccc tacccgcgtg aaactctttg aaaagtgggg ctggaagaag     1260

attgctacca tccagcagac cactgaggtc ttcacttcga ctctggacga cctggaggaa     1320

cgagtgaagg aggctggaat tgagattact ttccgccaga gtttcttctc agatccagct     1380

gtgcccgtca aaaacctgaa gcgccaggat gcccgaatca tcgtgggact tttctatgag     1440

actgaagccc ggaaagtttt ttgtgaggtg tacaaggagc gtctctttgg gaagaagtac     1500

gtctggttcc tcattgggtg gtatgctgac aattggttca agatctacga cccttctatc     1560

aactgcacag tggatgagat gactgaggcg gtggagggcc acatcacaac tgagattgtc     1620

atgctgaatc ctgccaatac ccgcagcatt tccaacatga catcccagga atttgtggag     1680

aaactaacca agcgactgaa aagacaccct gaggagacag gaggcttcca ggaggcaccg     1740

ctggcctatg atgccatctg ggccttggca ctggccctga acaagacatc tggaggaggc     1800

ggccgttctg gtgtgcgcct ggaggacttc aactacaaca accagaccat taccgaccaa     1860

atctaccggg caatgaactc ttcgtccttt gagggtgtct ctggccatgt ggtgtttgat     1920

gccagcggct ctcggatggc atggacgctt atcgagcagc ttcagggtgg cagctacaag     1980

aagattggct actatgacag caccaaggat gatctttcct ggtccaaaac agataaatgg     2040

attggagggt cccccccagc tgaccagacc ctggtcatca agacattccg cttcctgtca     2100

cagaaactct ttatctccgt ctcagttctc tccagcctgg gcattgtcct agctgttgtc     2160

tgtctgtcct ttaacatcta caactcacat gtccgttata tccagaactc acagcccaac     2220

ctgaacaacc tgactgctgt gggctgctca ctggctttag ctgctgtctt ccccctgggg     2280

ctcgatggtt accacattgg gaggaaccag tttcctttcg tctgccaggc ccgcctctgg     2340

ctcctgggcc tgggctttag tctgggctac ggttccatgt tcaccaagat ttggtgggtc     2400

cacacggtct tcacaaagaa ggaagaaaag aaggagtgga ggaagactct ggaaccctgg     2460

aagctgtatg ccacagtggg cctgctggtg ggcatggatg tcctcactct cgccatctgg     2520

cagatcgtgg accctctgca ccggaccatt gagacatttg ccaaggagga acctaaggaa     2580

gatattgacg tctctattct gccccagctg gagcattgca gctccaggaa gatgaataca     2640

tggcttggca ttttctatgg ttacaagggg ctgctgctgc tgctgggaat cttccttgct     2700

tatgagacca agagtgtgtc cactgagaag atcaatgatc accgggctgt gggcatggct     2760

atctacaatg tggcagtcct gtgcctcatc actgctcctg tcaccatgat tctgtccagc     2820

cagcaggatg cagcctttgc ctttgcctct cttgccatag ttttctcctc ctatatcact     2880

cttgttgtgc tctttgtgcc caagatgcgc aggctgatca cccgagggga atggcagtcg     2940

gaggcgcagg acaccatgaa gacagggtca tcgaccaaca acaacgagga ggagaagtcc     3000

cggctgttgg agaaggagaa ccgtgaactg gaaaagatca ttgctgagaa agaggagcgt     3060

gtctctgaac tgcgccatca actccagtct cggcagcagc tccgctcccg gcgccaccca     3120

ccgacacccc cagaaccctc tgggggcctg cccaggggac cccctgagcc ccccgaccgg     3180

cttagctgtg atgggagtcg agtgcatttg ctttataagt gagggtaggg tgagggagga     3240

caggccagta gggggaggga aagggagagg ggaagggcag gggactcagg aagcaggggg     3300

tccccatccc cagctgggaa gaacatgcta tccaatctca tctcttgtaa atacatgtcc     3360

ccctgtgagt tctgggctga tttgggtctc tcatacctct gggaaacaga cctttttctc     3420

tcttactgct tcatgtaatt ttgtatcacc tcttcacaat ttagttcgta cctggcttga     3480

agctgctcac tgctcacacg ctgcctcctc agcagcctca ctgcatcttt ctcttcccat     3540

gcaacaccct cttctagtta ccacggcaac ccctgcagct cctctgcctt tgtgctctgt     3600

tcctgtccag caggggtctc ccaacaagtg ctctttccac cccaaagggg cctctccttt     3660

tctccactgt cataatctct ttccatctta cttgcccttc tatactttct cacatgtggc     3720

tccccctgaa ttttgcttcc tttgggagct cattcttttc gccaaggctc acatgctcct     3780

tgcctctgct ctgtgcactc acgctcagca cacatgcatc ctcccctctc ctgcgtgtgc     3840

ccactgaaca tgctcatgtg tacacacgct tttcccgtat gctttcttca tgttcagtca     3900

catgtgctct cgggtgccct gcattcacag ctacgtgtgc ccctctcatg gtcatgggtc     3960

tgcccttgag cgtgtttggg taggcatgtg caatttgtct agcatgctga gtcatgtctt     4020

tcctatttgc acacgtccat gtttatccat gtactttccc tgtgtaccct ccatgtacct     4080

tgtgtacttt cttcccttaa atcatggtat tcttctgaca gagccatatg taccctaccc     4140

tgcacattgt tatgcacttt tccccaattc atgtttggtg gggccatcca caccctctcc     4200

ttgtcacaga atctccattt ctgctcagat tccccccatc tccattgcat tcatgtacta     4260

ccctcagtct acactcacaa tcatcttctc ccaagactgc tcccttttgt tttgtgtttt     4320

tttgagggga attaaggaaa aataagtggg ggcaggtttg gagagctgct tccagtggat     4380

agttgatgag aatcctgacc aaaggaaggc acccttgact gttgggatag acagatggac     4440

ctatggggtg ggaggtggtg tccctttcac actgtggtgt ctcttgggga aggatctccc     4500

cgaatctcaa taaaccagtg aacagtgtga ctcggcaaaa aaaaaaa                   4547


<210>  5
<211>  4297
<212>  DNA
<213>  Homo sapiens

<400>  5
cgttcctttc ctcctcgagg ttgcatcccc cctcccctcc ccgcccctcc gactgtcgct       60

cccacctcgg cgctcgcttc cctccccgcc cccttcctgc ctccccagct cccgcccgcc      120

cccccacccc ccgctgccgc gcgccgcccg tgacgtcaga gccccctccc agccccacat      180

ctccctcctg ctcctcctcc tcccctccgt cggtcagtca gtccgcgagg agagtccgcg      240

gtggcggcga cggtggcgag agccgcgggg gccgtaggaa gccaaccttc cctgcttctc      300

cggggccctc gccccctcct ccccacaaaa tcagggatgg aggcgcctcc ccggcaccct      360

cttagcagcc ctccccagga aaagtgtccc ccctgagctc ctaacgctcc ccaacagcta      420

cccctgcccc ccacgccatg gggcccgggg ccccttttgc ccgggtgggg tggccactgc      480

cgcttctggt tgtgatggcg gcaggggtgg ctccggtgtg ggcctcccac tccccccatc      540

tcccgcggcc tcactcgcgg gtccccccgc acccctcctc agaacggcgc gcagtgtaca      600

tcggggcact gtttcccatg agcgggggct ggccaggggg ccaggcctgc cagcccgcgg      660

tggagatggc gctggaggac gtgaatagcc gcagggacat cctgccggac tatgagctca      720

agctcatcca ccacgacagc aagtgtgatc caggccaagc caccaagtac ctatatgagc      780

tgctctacaa cgaccctatc aagatcatcc ttatgcctgg ctgcagctct gtctccacgc      840

tggtggctga ggctgctagg atgtggaacc tcattgtgct ttcctatggc tccagctcac      900

cagccctgtc aaaccggcag cgtttcccca ctttcttccg aacgcaccca tcagccacac      960

tccacaaccc tacccgcgtg aaactctttg aaaagtgggg ctggaagaag attgctacca     1020

tccagcagac cactgaggtc ttcacttcga ctctggacga cctggaggaa cgagtgaagg     1080

aggctggaat tgagattact ttccgccaga gtttcttctc agatccagct gtgcccgtca     1140

aaaacctgaa gcgccaggat gcccgaatca tcgtgggact tttctatgag actgaagccc     1200

ggaaagtttt ttgtgaggtg tacaaggagc gtctctttgg gaagaagtac gtctggttcc     1260

tcattgggtg gtatgctgac aattggttca agatctacga cccttctatc aactgcacag     1320

tggatgagat gactgaggcg gtggagggcc acatcacaac tgagattgtc atgctgaatc     1380

ctgccaatac ccgcagcatt tccaacatga catcccagga atttgtggag aaactaacca     1440

agcgactgaa aagacaccct gaggagacag gaggcttcca ggaggcaccg ctggcctatg     1500

atgccatctg ggccttggca ctggccctga acaagacatc tggaggaggc ggccgttctg     1560

gtgtgcgcct ggaggacttc aactacaaca accagaccat taccgaccaa atctaccggg     1620

caatgaactc ttcgtccttt gagggtgtct ctggccatgt ggtgtttgat gccagcggct     1680

ctcggatggc atggacgctt atcgagcagc ttcagggtgg cagctacaag aagattggct     1740

actatgacag caccaaggat gatctttcct ggtccaaaac agataaatgg attggagggt     1800

cccccccagc tgaccagacc ctggtcatca agacattccg cttcctgtca cagaaactct     1860

ttatctccgt ctcagttctc tccagcctgg gcattgtcct agctgttgtc tgtctgtcct     1920

ttaacatcta caactcacat gtccgttata tccagaactc acagcccaac ctgaacaacc     1980

tgactgctgt gggctgctca ctggctttag ctgctgtctt ccccctgggg ctcgatggtt     2040

accacattgg gaggaaccag tttcctttcg tctgccaggc ccgcctctgg ctcctgggcc     2100

tgggctttag tctgggctac ggttccatgt tcaccaagat ttggtgggtc cacacggtct     2160

tcacaaagaa ggaagaaaag aaggagtgga ggaagactct ggaaccctgg aagctgtatg     2220

ccacagtggg cctgctggtg ggcatggatg tcctcactct cgccatctgg cagatcgtgg     2280

accctctgca ccggaccatt gagacatttg ccaaggagga acctaaggaa gatattgacg     2340

tctctattct gccccagctg gagcattgca gctccaggaa gatgaataca tggcttggca     2400

ttttctatgg ttacaagggg ctgctgctgc tgctgggaat cttccttgct tatgagacca     2460

agagtgtgtc cactgagaag atcaatgatc accgggctgt gggcatggct atctacaatg     2520

tggcagtcct gtgcctcatc actgctcctg tcaccatgat tctgtccagc cagcaggatg     2580

cagcctttgc ctttgcctct cttgccatag ttttctcctc ctatatcact cttgttgtgc     2640

tctttgtgcc caagatgcgc aggctgatca cccgagggga atggcagtcg gaggcgcagg     2700

acaccatgaa gacagggtca tcgaccaaca acaacgagga ggagaagtcc cggctgttgg     2760

agaaggagaa ccgtgaactg gaaaagatca ttgctgagaa agaggagcgt gtctctgaac     2820

tgcgccatca actccagtct cggcagcagc tccgctcccg gcgccaccca ccgacacccc     2880

cagaaccctc tgggggcctg cccaggggac cccctgagcc ccccgaccgg cttagctgtg     2940

atgggagtcg agtgcatttg ctttataagt gagggtaggg tgagggagga caggccagta     3000

gggggaggga aagggagagg ggaagggcag gggactcagg aagcaggggg tccccatccc     3060

cagctgggaa gaacatgcta tccaatctca tctcttgtaa atacatgtcc ccctgtgagt     3120

tctgggctga tttgggtctc tcatacctct gggaaacaga cctttttctc tcttactgct     3180

tcatgtaatt ttgtatcacc tcttcacaat ttagttcgta cctggcttga agctgctcac     3240

tgctcacacg ctgcctcctc agcagcctca ctgcatcttt ctcttcccat gcaacaccct     3300

cttctagtta ccacggcaac ccctgcagct cctctgcctt tgtgctctgt tcctgtccag     3360

caggggtctc ccaacaagtg ctctttccac cccaaagggg cctctccttt tctccactgt     3420

cataatctct ttccatctta cttgcccttc tatactttct cacatgtggc tccccctgaa     3480

ttttgcttcc tttgggagct cattcttttc gccaaggctc acatgctcct tgcctctgct     3540

ctgtgcactc acgctcagca cacatgcatc ctcccctctc ctgcgtgtgc ccactgaaca     3600

tgctcatgtg tacacacgct tttcccgtat gctttcttca tgttcagtca catgtgctct     3660

cgggtgccct gcattcacag ctacgtgtgc ccctctcatg gtcatgggtc tgcccttgag     3720

cgtgtttggg taggcatgtg caatttgtct agcatgctga gtcatgtctt tcctatttgc     3780

acacgtccat gtttatccat gtactttccc tgtgtaccct ccatgtacct tgtgtacttt     3840

cttcccttaa atcatggtat tcttctgaca gagccatatg taccctaccc tgcacattgt     3900

tatgcacttt tccccaattc atgtttggtg gggccatcca caccctctcc ttgtcacaga     3960

atctccattt ctgctcagat tccccccatc tccattgcat tcatgtacta ccctcagtct     4020

acactcacaa tcatcttctc ccaagactgc tcccttttgt tttgtgtttt tttgagggga     4080

attaaggaaa aataagtggg ggcaggtttg gagagctgct tccagtggat agttgatgag     4140

aatcctgacc aaaggaaggc acccttgact gttgggatag acagatggac ctatggggtg     4200

ggaggtggtg tccctttcac actgtggtgt ctcttgggga aggatctccc cgaatctcaa     4260

taaaccagtg aacagtgtga ctcggcaaaa aaaaaaa                              4297


<210>  6
<211>  4361
<212>  DNA
<213>  Homo sapiens

<400>  6
ccctctcttc cccccgccct gccttccctt gcaccctcct tcttccctcc gcccgggagc       60

tctccctggt ccccggcgcc gcctccttcc ctcccggctc cccgctcccc gctcccgtgg      120

ctgccgccgc cccggggaag aagagacagg ggtggggttt gggggaagcg agagaggagg      180

ggagagaccc tggccaggct ggagcctgga ttcgagggga ggagggacgg gaggaggaga      240

aaggtggagg agaagggagg ggggagcggg gaggagcggc cgggcctggg gccttgaggc      300

ccggggagag ccggggagcc gggcccgcgc gccgagatgt tgctgctgct gctactggcg      360

ccactcttcc tccgcccccc gggcgcgggc ggggcgcaga cccccaacgc cacctcagaa      420

ggttgccaga tcatacaccc gccctgggaa gggggcatca ggtaccgggg cctgactcgg      480

gaccaggtga aggctatcaa cttcctgcca gtggactatg agattgagta tgtgtgccgg      540

ggggagcgcg aggtggtggg gcccaaggtc cgcaagtgcc tggccaacgg ctcctggaca      600

gatatggaca cacccagccg ctgtgtgaat cgaacgccac actcagaacg gcgcgcagtg      660

tacatcgggg cactgtttcc catgagcggg ggctggccag ggggccaggc ctgccagccc      720

gcggtggaga tggcgctgga ggacgtgaat agccgcaggg acatcctgcc ggactatgag      780

ctcaagctca tccaccacga cagcaagtgt gatccaggcc aagccaccaa gtacctatat      840

gagctgctct acaacgaccc tatcaagatc atccttatgc ctggctgcag ctctgtctcc      900

acgctggtgg ctgaggctgc taggatgtgg aacctcattg tgctttccta tggctccagc      960

tcaccagccc tgtcaaaccg gcagcgtttc cccactttct tccgaacgca cccatcagcc     1020

acactccaca accctacccg cgtgaaactc tttgaaaagt ggggctggaa gaagattgct     1080

accatccagc agaccactga ggtcttcact tcgactctgg acgacctgga ggaacgagtg     1140

aaggaggctg gaattgagat tactttccgc cagagtttct tctcagatcc agctgtgccc     1200

gtcaaaaacc tgaagcgcca ggatgcccga atcatcgtgg gacttttcta tgagactgaa     1260

gcccggaaag ttttttgtga ggtgtacaag gagcgtctct ttgggaagaa gtacgtctgg     1320

ttcctcattg ggtggtatgc tgacaattgg ttcaagatct acgacccttc tatcaactgc     1380

acagtggatg agatgactga ggcggtggag ggccacatca caactgagat tgtcatgctg     1440

aatcctgcca atacccgcag catttccaac atgacatccc aggaatttgt ggagaaacta     1500

accaagcgac tgaaaagaca ccctgaggag acaggaggct tccaggaggc accgctggcc     1560

tatgatgcca tctgggcctt ggcactggcc ctgaacaaga catctggagg aggcggccgt     1620

tctggtgtgc gcctggagga cttcaactac aacaaccaga ccattaccga ccaaatctac     1680

cgggcaatga actcttcgtc ctttgagggt gtctctggcc atgtggtgtt tgatgccagc     1740

ggctctcgga tggcatggac gcttatcgag cagcttcagg gtggcagcta caagaagatt     1800

ggctactatg acagcaccaa ggatgatctt tcctggtcca aaacagataa atggattgga     1860

gggtcccccc cagctgacca gaccctggtc atcaagacat tccgcttcct gtcacagaaa     1920

ctctttatct ccgtctcagt tctctccagc ctgggcattg tcctagctgt tgtctgtctg     1980

tcctttaaca tctacaactc acatgtccgt tatatccaga actcacagcc caacctgaac     2040

aacctgactg ctgtgggctg ctcactggct ttagctgctg tcttccccct ggggctcgat     2100

ggttaccaca ttgggaggaa ccagtttcct ttcgtctgcc aggcccgcct ctggctcctg     2160

ggcctgggct ttagtctggg ctacggttcc atgttcacca agatttggtg ggtccacacg     2220

gtcttcacaa agaaggaaga aaagaaggag tggaggaaga ctctggaacc ctggaagctg     2280

tatgccacag tgggcctgct ggtgggcatg gatgtcctca ctctcgccat ctggcagatc     2340

gtggaccctc tgcaccggac cattgagaca tttgccaagg aggaacctaa ggaagatatt     2400

gacgtctcta ttctgcccca gctggagcat tgcagctcca ggaagatgaa tacatggctt     2460

ggcattttct atggttacaa ggggctgctg ctgctgctgg gaatcttcct tgcttatgag     2520

accaagagtg tgtccactga gaagatcaat gatcaccggg ctgtgggcat ggctatctac     2580

aatgtggcag tcctgtgcct catcactgct cctgtcacca tgattctgtc cagccagcag     2640

gatgcagcct ttgcctttgc ctctcttgcc atagttttct cctcctatat cactcttgtt     2700

gtgctctttg tgcccaagat gcgcaggctg atcacccgag gggaatggca gtcggaggcg     2760

caggacacca tgaagacagg gtcatcgacc aacaacaacg aggaggagaa gtcccggctg     2820

ttggagaagg agaaccgtga actggaaaag atcattgctg agaaagagga gcgtgtctct     2880

gaactgcgcc atcaactcca gtctcggcag cagctccgct cccggcgcca cccaccgaca     2940

cccccagaac cctctggggg cctgcccagg ggaccccctg agccccccga ccggcttagc     3000

tgtgatggga gtcgagtgca tttgctttat aagtgagggt agggtgaggg aggacaggcc     3060

agtaggggga gggaaaggga gaggggaagg gcaggggact caggaagcag ggggtcccca     3120

tccccagctg ggaagaacat gctatccaat ctcatctctt gtaaatacat gtccccctgt     3180

gagttctggg ctgatttggg tctctcatac ctctgggaaa cagacctttt tctctcttac     3240

tgcttcatgt aattttgtat cacctcttca caatttagtt cgtacctggc ttgaagctgc     3300

tcactgctca cacgctgcct cctcagcagc ctcactgcat ctttctcttc ccatgcaaca     3360

ccctcttcta gttaccacgg caacccctgc agctcctctg cctttgtgct ctgttcctgt     3420

ccagcagggg tctcccaaca agtgctcttt ccaccccaaa ggggcctctc cttttctcca     3480

ctgtcataat ctctttccat cttacttgcc cttctatact ttctcacatg tggctccccc     3540

tgaattttgc ttcctttggg agctcattct tttcgccaag gctcacatgc tccttgcctc     3600

tgctctgtgc actcacgctc agcacacatg catcctcccc tctcctgcgt gtgcccactg     3660

aacatgctca tgtgtacaca cgcttttccc gtatgctttc ttcatgttca gtcacatgtg     3720

ctctcgggtg ccctgcattc acagctacgt gtgcccctct catggtcatg ggtctgccct     3780

tgagcgtgtt tgggtaggca tgtgcaattt gtctagcatg ctgagtcatg tctttcctat     3840

ttgcacacgt ccatgtttat ccatgtactt tccctgtgta ccctccatgt accttgtgta     3900

ctttcttccc ttaaatcatg gtattcttct gacagagcca tatgtaccct accctgcaca     3960

ttgttatgca cttttcccca attcatgttt ggtggggcca tccacaccct ctccttgtca     4020

cagaatctcc atttctgctc agattccccc catctccatt gcattcatgt actaccctca     4080

gtctacactc acaatcatct tctcccaaga ctgctccctt ttgttttgtg tttttttgag     4140

gggaattaag gaaaaataag tgggggcagg tttggagagc tgcttccagt ggatagttga     4200

tgagaatcct gaccaaagga aggcaccctt gactgttggg atagacagat ggacctatgg     4260

ggtgggaggt ggtgtccctt tcacactgtg gtgtctcttg gggaaggatc tccccgaatc     4320

tcaataaacc agtgaacagt gtgactcggc aaaaaaaaaa a                         4361


