                         SEQUENCE LISTING

<110>  YALE UNIVERSITY
       MEHAL, Wajahat Z
       KYRIAKIDES, Themis
 
<120>  COMPOSITIONS AND METHODS FOR INHIBITING INFLAMMATION FROM AND 
       REJECTION OF BIOMATERIALS AND OTHER METHODS

<130>  Y03-131PCT

<140>  PCT/US10/50544
<141>  2010-09-28

<150>  US61277798
<151>  2009-09-29

<150>  US61281823
<151>  2009-11-23

<160>  38    

<170>  PatentIn version 3.5

<210>  1
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic. phosphorothioate backbone.

<400>  1
agaucacccu ccuuaaauau u                                                 21


<210>  2
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic. phosphorothioate backbone.


<220>
<221>  modified_base
<222>  (4)..(4)
<223>  um is residue 4, 10, 14, 18.

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  um is residue 4, 10, 14, 18.

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  um is residue 4, 10, 14, 18.

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  um is residue 4, 10, 14, 18.

<400>  2
agaucacccu ccuuaaauau u                                                 21


<210>  3
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic. phosphorothioate backbone.


<220>
<221>  modified_base
<222>  (8)..(8)
<223>  gm is residue 8.  um is residue 17.

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  gm is residue 8.  um is residue 17.

<400>  3
uauuuaagga gggugaucuu u                                                 21


<210>  4
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic. phosphorothioate backbone.


<220>
<221>  modified_base
<222>  (9)..(9)
<223>  gm is residue 9, 12, 15.

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  gm is residue 9, 12, 15.

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  gm is residue 9, 12, 15.

<400>  4
uauuuaagga gggugaucuu u                                                 21


<210>  5
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic. phosphorothioate backbone. This sequence is the 5' 
       oligonucleotide of Seq. Id. 25.


<220>
<221>  modified_base
<222>  (2)..(2)
<223>  gm is residue 2, 5, 10.

<220>
<221>  modified_base
<222>  (5)..(5)
<223>  gm is residue 2, 5, 10.

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  gm is residue 2, 5, 10.

<400>  5
ugcuguucug                                                              10


<210>  6
<211>  10
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic. phosphorothioate backbone. This sequence is the 3' 
       oligonucleotide of Seq. Id. 25.


<220>
<221>  modified_base
<222>  (1)..(1)
<223>  gm is residue 1, 6, 9.

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  gm is residue 1, 6, 9.

<220>
<221>  modified_base
<222>  (9)..(9)
<223>  gm is residue 1, 6, 9.

<400>  6
gucuugucgu                                                              10


<210>  7
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic. phosphorothioate backbone.


<220>
<221>  modified_base
<222>  (5)..(5)
<223>  um is residue 5, 14, 17.

gm is residue 11.

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  gm is residue 11.

um is residue 5, 14, 17.

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  gm is residue 11.

um is residue 5, 14, 17.

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  gm is residue 11.

um is residue 5, 14, 17.

<400>  7
uauuuaagga gggugaucuu u                                                 21


<210>  8
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic. phosphorothioate backbone.


<220>
<221>  modified_base
<222>  (2)..(2)
<223>  gm is residue 2, 13.

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  gm is residue 2, 13.

<400>  8
agaccuaccu ccggaucaau u                                                 21


<210>  9
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic. phosphorothioate backbone.


<220>
<221>  modified_base
<222>  (6)..(6)
<223>  um is residue 6, 10, 16.

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  um is residue 6, 10, 16.

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  um is residue 6, 10, 16.

<400>  9
agaccuaccu ccggaucaau u                                                 21


<210>  10
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic. phosphorothioate backbone.


<220>
<221>  modified_base
<222>  (5)..(5)
<223>  um is residue 5, 13, 17.

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  um is residue 5, 13, 17.

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  um is residue 5, 13, 17.

<400>  10
uugauccgga gguaggucuu u                                                 21


<210>  11
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic. phosphorothioate backbone.


<220>
<221>  modified_base
<222>  (9)..(9)
<223>  gm is residue 9, 12.   um is residue 17.

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  gm is residue 9, 12.   um is residue 17.

<220>
<221>  modified_base
<222>  (17)..(17)
<223>  gm is residue 9, 12.   um is residue 17.

<400>  11
uugauccgga gguaggucuu u                                                 21


<210>  12
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic. phosphorothioate backbone.


<220>
<221>  modified_base
<222>  (5)..(5)
<223>  um is residue 5.  gm is residue 8, 11, 16.

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  um is residue 5.  gm is residue 8, 11, 16.

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  um is residue 5.  gm is residue 8, 11, 16.

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  um is residue 5.  gm is residue 8, 11, 16.

<400>  12
uugauccgga gguaggucuu u                                                 21


<210>  13
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic. phosphorothioate backbone.


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  RNA segment

<220>
<221>  modified_base
<222>  (2)..(2)
<223>  um is residue 2, 10, 19.

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  um is residue 2, 10, 19.

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  um is residue 2, 10, 19.

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  DNA segment

<400>  13
cugaagaccu gaagacaaut t                                                 21


<210>  14
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic. phosphorothioate backbone.


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  RNA segment

<220>
<221>  modified_base
<222>  (3)..(3)
<223>  gm is rresidue 3, 6, 11,14.

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  gm is rresidue 3, 6, 11,14.

<220>
<221>  modified_base
<222>  (11)..(11)
<223>  gm is rresidue 3, 6, 11,14.

<220>
<221>  modified_base
<222>  (14)..(14)
<223>  gm is rresidue 3, 6, 11,14.

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  DNA segment

<400>  14
cugaagaccu gaagacaaut t                                                 21


<210>  15
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic. phosphorothioate backbone.


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  RNA segment.

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  um is residue 8, 13, 16.

<220>
<221>  modified_base
<222>  (13)..(13)
<223>  um is residue 8, 13, 16.

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  um is residue 8, 13, 16.

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  DNA segment.

<400>  15
auugucuuca ggucuucagt t                                                 21


<210>  16
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic. phosphorothioate backbone.


<220>
<221>  misc_feature
<222>  (1)..(19)
<223>  RNA segment.

<220>
<221>  modified_base
<222>  (4)..(4)
<223>  gm is residue 4, 12, 19.

<220>
<221>  modified_base
<222>  (12)..(12)
<223>  gm is residue 4, 12, 19.

<220>
<221>  modified_base
<222>  (19)..(19)
<223>  gm is residue 4, 12, 19.

<220>
<221>  misc_feature
<222>  (20)..(21)
<223>  DNA segment.

<400>  16
auugucuuca ggucuucagt t                                                 21


<210>  17
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic. phosphorothioate backbone.


<220>
<221>  modified_base
<222>  (3)..(3)
<223>  um is residue 3, 6, 8, 13, 14, 16, 18.

<220>
<221>  modified_base
<222>  (6)..(6)
<223>  um is residue 3, 6, 8, 13, 14, 16, 18.

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  um is residue 3, 6, 8, 13, 14, 16, 18.

<220>
<221>  modified_base
<222>  (13)..(14)
<223>  um is residue 3, 6, 8, 13, 14, 16, 18.

<220>
<221>  modified_base
<222>  (16)..(16)
<223>  um is residue 3, 6, 8, 13, 14, 16, 18.

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  um is residue 3, 6, 8, 13, 14, 16, 18.

<400>  17
gauuaugucc gguuauguau u                                                 21


<210>  18
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic. phosphorothioate backbone.


<220>
<221>  modified_base
<222>  (5)..(5)
<223>  um is residue 5, 15, 18.

<220>
<221>  modified_base
<222>  (15)..(15)
<223>  um is residue 5, 15, 18.

<220>
<221>  modified_base
<222>  (18)..(18)
<223>  um is residue 5, 15, 18.

<400>  18
uacauaaccg gacauaaucu u                                                 21


<210>  19
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic. phosphorothioate backbone.


<220>
<221>  modified_base
<222>  (7)..(7)
<223>  gm is residue 7.  2'-O-methyladenosine is residue 8.

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  gm is residue 7.  2'-O-methyladenosine is residue 8.

<400>  19
ctatctgacg ttctctgt                                                     18


<210>  20
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic. phosphorothioate backbone.


<220>
<221>  modified_base
<222>  (7)..(7)
<223>  gm is residue 7.  uracil is residue 8.

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  gm is residue 7.  uracil is residue 8.

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  uracil is a modified base for a DNA sequence.

<400>  20
ctatctgncg ttctctgt                                                     18


<210>  21
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic. phosphorothioate backbone.


<220>
<221>  modified_base
<222>  (7)..(7)
<223>  gm is residue 7. 2'-O-methyladenosine is residue 8.

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  gm is residue 7. 2'-O-methyladenosine is residue 8.

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  gm is residue 7. 2'-O-methyladenosine is residue 8.  
       2'-deoxy-7-deazaguanosine is residue 10.

<400>  21
ctatctgacg ttctctgt                                                     18


<210>  22
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic. phosphorothioate backbone.


<220>
<221>  modified_base
<222>  (7)..(7)
<223>  gm is residue 7. uracil is residue 8. 2'-deoxy-7-deazaguanosine 
       is residue 10.

<220>
<221>  modified_base
<222>  (8)..(8)
<223>  gm is residue 7. uracil is residue 8. 2'-deoxy-7-deazaguanosine 
       is residue 10.

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  uracil is a modified base for a DNA sequence.

<220>
<221>  modified_base
<222>  (10)..(10)
<223>  gm is residue 7. uracil is residue 8. 2'-deoxy-7-deazaguanosine 
       is residue 10.

<400>  22
ctatctgncg ttctctgt                                                     18


<210>  23
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic. phosphorothioate backbone.

<400>  23
tcctggaggg gaagt                                                        15


<210>  24
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic. phosphorothioate backbone.

<400>  24
tcctggcggg gaagt                                                        15


<210>  25
<211>  21
<212>  RNA
<213>  Artificial Sequence

<220>
<223>  synthetic. phosphorothioate backbone.


<220>
<221>  modified_base
<222>  (11)..(11)
<223>  a glycerol linker is residue 11. The component 5' oligonucleotide
       is also presented in Seq. Id. 5.  The component 3' 
       oligonucleotide is also presented in Seq. Id. 6.

<220>
<221>  misc_feature
<222>  (11)..(11)
<223>  glycerol linker:  see: J. Med. Chem., 2009, 5, 551-558 and J. 
       Med. Chem., 2009, 52, 5108-5114.

<400>  25
ugcuguucug ngucuugucg u                                                 21


<210>  26
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  26
tcctggcggg gaagt                                                        15


<210>  27
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  27
tcctggaggg gaagt                                                        15


<210>  28
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  28
tcctggatgg gaagt                                                        15


<210>  29
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  29
cctggatggg aattcccatc cagg                                              24


<210>  30
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  30
ttcccatcca ggcctggatg ggaa                                              24


<210>  31
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  31
cctggatggg aacttaccgc tgca                                              24


<210>  32
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  32
gggggggggg gggggggggg                                                   20


<210>  33
<211>  24
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  33
ttagggttag ggttagggtt aggg                                              24


<210>  34
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  34
tgactgtgaa ggttagagat ga                                                22


<210>  35
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  35
ctcctattgg gggtttccta t                                                 21


<210>  36
<211>  15
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  36
tcctggaggg gttgt                                                        15


<210>  37
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  37
tgcttgcaag cttgcaagca                                                   20


<210>  38
<211>  18
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  synthetic

<400>  38
tgctcctgga ggggttgt                                                     18


