			SEQUENCE LISTING

<110> Gilson, Lynne
<111> Collier, Steven James
<112> Sukumaran, Joly
<113> Yeo, Wan Lin
<114> Alvizo, Oscar
<115> Teo, Ee Ling
<116> Wilson, Robert John
<117> Xu Junye
 
<120> Variant LovD Polypeptides and Their Uses
 
<130> 376247-043US (105191) {CX2-022}
 
<141> 2010-09-24
 
<160> 20
 
<210> 1
<211> 1242
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Codon optimized Aspergillus terreus lovD
 
<400> 1
atgggttcta tcattgatgc ggctgcggcc gcggacccgg tggttctgat ggaaacggct 60
ttccgtaaag cggttaaaag ccgccagatt ccgggtgctg ttattatggc gcgtgattgt 120
agtggtaacc tgaactacac tcgctgtttc ggcgcacgca ctgtgcgtcg cgacgagtgc 180
aatcaattac caccgctgca ggtggataca ccatgtcgtc tggcaagcgc tactaaatta 240
ctgaccacga ttatggcact gcagtgcatg gaacgcggcc tggtagactt ggatgaaact 300
gttgaccgcc tgctgccgga cctgagcgcg atgccggtgc tggaaggctt tgatgatgcc 360
ggcaacgccc gtctgcgcga acgccgtggt aaaattacgt tacgccatct gctgacacac 420
accagcggtc tgtcgtacgt cttcctgcat ccgctgctgc gcgagtatat ggcccagggt 480
catttgcaga gcgctgagaa gtttggcatt cagtctcgtc tggcgccgcc agctgttaat 540
gatccaggcg cggaatggat ttatggcgct aatctggact gggcaggcaa attagtggaa 600
cgcgcaacgg gcttggacct ggaacagtac ttgcaggaga acatttgcgc gccgctgggc 660
atcactgata tgacgttcaa actgcagcag cgtccggata tgctggcacg tcgtgccgac 720
cagacccacc gcaactccgc ggatggtcgt ctgcgctatg atgactctgt gtattttcgc 780
gcggacggtg aagagtgttt cgggggccag ggcgtgttca gcggtccagg cagttacatg 840
aaggttctgc actctctgct gaaacgtgac ggcctgttgc tgcagccaca aaccgtggat 900
ctgatgttcc agccggcgct ggaaccgcgc ttggaagaac aaatgaacca gcatatggac 960
gcgtcgccgc acatcaacta tggcggtcca atgcctatgg tcctgcgtcg cagcttcggc 1020
ctgggtggta tcattgcact ggaggatctg gatggtgaga actggcgtcg taaaggctcg 1080
ctgacgtttg gtggcggtcc aaacattgtt tggcagattg acccgaaagc gggtctgtgt 1140
actttagcct ttttccagct ggaaccgtgg aacgacccgg tgtgtcgtga cctgactcgc 1200
acctttgagc acgcgatcta tgcacagtat caacagggct aa                    1242

 
<210> 2
<211> 413
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Codon optimized Aspergillus terreus lovD
 
<400> 2
Met Gly Ser Ile Ile Asp Ala Ala Ala Ala Ala Asp Pro Val Val Leu 
1               5                   10                  15      
Met Glu Thr Ala Phe Arg Lys Ala Val Lys Ser Arg Gln Ile Pro Gly 
            20                  25                  30          
Ala Val Ile Met Ala Arg Asp Cys Ser Gly Asn Leu Asn Tyr Thr Arg 
        35                  40                  45              
Cys Phe Gly Ala Arg Thr Val Arg Arg Asp Glu Cys Asn Gln Leu Pro 
    50                  55                  60                  
Pro Leu Gln Val Asp Thr Pro Cys Arg Leu Ala Ser Ala Thr Lys Leu 
65                  70                  75                  80  
Leu Thr Thr Ile Met Ala Leu Gln Cys Met Glu Arg Gly Leu Val Asp 
                85                  90                  95      
Leu Asp Glu Thr Val Asp Arg Leu Leu Pro Asp Leu Ser Ala Met Pro 
            100                 105                 110         
Val Leu Glu Gly Phe Asp Asp Ala Gly Asn Ala Arg Leu Arg Glu Arg 
        115                 120                 125             
Arg Gly Lys Ile Thr Leu Arg His Leu Leu Thr His Thr Ser Gly Leu 
    130                 135                 140                 
Ser Tyr Val Phe Leu His Pro Leu Leu Arg Glu Tyr Met Ala Gln Gly 
145                 150                 155                 160 
His Leu Gln Ser Ala Glu Lys Phe Gly Ile Gln Ser Arg Leu Ala Pro 
                165                 170                 175     
Pro Ala Val Asn Asp Pro Gly Ala Glu Trp Ile Tyr Gly Ala Asn Leu 
            180                 185                 190         
Asp Trp Ala Gly Lys Leu Val Glu Arg Ala Thr Gly Leu Asp Leu Glu 
        195                 200                 205             
Gln Tyr Leu Gln Glu Asn Ile Cys Ala Pro Leu Gly Ile Thr Asp Met 
    210                 215                 220                 
Thr Phe Lys Leu Gln Gln Arg Pro Asp Met Leu Ala Arg Arg Ala Asp 
225                 230                 235                 240 
Gln Thr His Arg Asn Ser Ala Asp Gly Arg Leu Arg Tyr Asp Asp Ser 
                245                 250                 255     
Val Tyr Phe Arg Ala Asp Gly Glu Glu Cys Phe Gly Gly Gln Gly Val 
            260                 265                 270         
Phe Ser Gly Pro Gly Ser Tyr Met Lys Val Leu His Ser Leu Leu Lys 
        275                 280                 285             
Arg Asp Gly Leu Leu Leu Gln Pro Gln Thr Val Asp Leu Met Phe Gln 
    290                 295                 300                 
Pro Ala Leu Glu Pro Arg Leu Glu Glu Gln Met Asn Gln His Met Asp 
305                 310                 315                 320 
Ala Ser Pro His Ile Asn Tyr Gly Gly Pro Met Pro Met Val Leu Arg 
                325                 330                 335     
Arg Ser Phe Gly Leu Gly Gly Ile Ile Ala Leu Glu Asp Leu Asp Gly 
            340                 345                 350         
Glu Asn Trp Arg Arg Lys Gly Ser Leu Thr Phe Gly Gly Gly Pro Asn 
        355                 360                 365             
Ile Val Trp Gln Ile Asp Pro Lys Ala Gly Leu Cys Thr Leu Ala Phe 
    370                 375                 380                 
Phe Gln Leu Glu Pro Trp Asn Asp Pro Val Cys Arg Asp Leu Thr Arg 
385                 390                 395                 400 
Thr Phe Glu His Ala Ile Tyr Ala Gln Tyr Gln Gln Gly             
                405                 410                         

 
<210> 3
<211> 1242
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of lovD
 
<400> 3
atgggttcta tcattgatgc ggctgcggcc gcggacccgg tggttctgat ggaaacggct 60
ttccgtaaag cggttaaaag ccgccagatt ccgggtgctg ttattatggc gcgtgattgt 120
agtggtaacc tgaactacac tcgctgtttc ggcgcacgca ctgtgcgtcg cgacgagtgc 180
aatcaattac caccgctgca ggtggataca ccatgtcgtc tggcaagcgc tactaaatta 240
ctgaccacga ttatggcact gcagtgcatg gaacgcggcc tggtagactt ggatgaaact 300
gttgaccgcc tgctgccgga cctgagcgcg atgccggtgc tggaaggctt tgatgatgcc 360
ggcaacgccc gtctgcgcga acgccgtggt aaaattacgt tacgccatct gctgacacac 420
accagcggtc tgtcgtacgt cttcctgcat ccgctgctgc gcgagtatat ggcccagggt 480
catttgcaga gcgctgagaa gtttggcatt cagtctcgtc tggcgccgcc agctgttaat 540
gatccaggcg cggaatggat ttatggcgct aatctggact gggcaggcaa attagtggaa 600
cgcgcaacgg gcttggacct ggaacagtac ttgcaggaga acatttgcgc gccgctgggc 660
atcactgata tgacgttcaa actgcagcag cgtccggata tgctggcacg tcgtgccgac 720
cagacccacc gcaactccgc ggatggtcgt ctgcgctatg atgactctgt gtattttcgc 780
gcggacggtg aagagtgttt cgggggccag ggcgtgttca gcggtccagg cagttacatg 840
aaggttctgc actctctgct gaaacgtgac ggcctgttgc tgcagccaca aaccgtggat 900
ctgatgttcc agccggcgct ggaaccgcgc ttggaagaac aaatgaacca gcatatggac 960
gcgtcgccgc acatcaacta tggcggtcca atgcctatgg tcctgcgtcg cagcttcggc 1020
ctgggtggta tcattgcact ggaggatctg gatggtgaga actggcgtcg taaaggctcg 1080
atgacgtttg gtggcggtcc aaacattgtt tggcagattg acccgaaagc gggtctgtgt 1140
actttagcct ttttccagct ggaaccgtgg aacgacccgg tgtgtcgtga cctgactcgc 1200
acctttgagc acgcgatcta tgcacagtat caacagggct aa                    1242

 
<210> 4
<211> 413
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of lovD
 
<400> 4
Met Gly Ser Ile Ile Asp Ala Ala Ala Ala Ala Asp Pro Val Val Leu 
1               5                   10                  15      
Met Glu Thr Ala Phe Arg Lys Ala Val Lys Ser Arg Gln Ile Pro Gly 
            20                  25                  30          
Ala Val Ile Met Ala Arg Asp Cys Ser Gly Asn Leu Asn Tyr Thr Arg 
        35                  40                  45              
Cys Phe Gly Ala Arg Thr Val Arg Arg Asp Glu Cys Asn Gln Leu Pro 
    50                  55                  60                  
Pro Leu Gln Val Asp Thr Pro Cys Arg Leu Ala Ser Ala Thr Lys Leu 
65                  70                  75                  80  
Leu Thr Thr Ile Met Ala Leu Gln Cys Met Glu Arg Gly Leu Val Asp 
                85                  90                  95      
Leu Asp Glu Thr Val Asp Arg Leu Leu Pro Asp Leu Ser Ala Met Pro 
            100                 105                 110         
Val Leu Glu Gly Phe Asp Asp Ala Gly Asn Ala Arg Leu Arg Glu Arg 
        115                 120                 125             
Arg Gly Lys Ile Thr Leu Arg His Leu Leu Thr His Thr Ser Gly Leu 
    130                 135                 140                 
Ser Tyr Val Phe Leu His Pro Leu Leu Arg Glu Tyr Met Ala Gln Gly 
145                 150                 155                 160 
His Leu Gln Ser Ala Glu Lys Phe Gly Ile Gln Ser Arg Leu Ala Pro 
                165                 170                 175     
Pro Ala Val Asn Asp Pro Gly Ala Glu Trp Ile Tyr Gly Ala Asn Leu 
            180                 185                 190         
Asp Trp Ala Gly Lys Leu Val Glu Arg Ala Thr Gly Leu Asp Leu Glu 
        195                 200                 205             
Gln Tyr Leu Gln Glu Asn Ile Cys Ala Pro Leu Gly Ile Thr Asp Met 
    210                 215                 220                 
Thr Phe Lys Leu Gln Gln Arg Pro Asp Met Leu Ala Arg Arg Ala Asp 
225                 230                 235                 240 
Gln Thr His Arg Asn Ser Ala Asp Gly Arg Leu Arg Tyr Asp Asp Ser 
                245                 250                 255     
Val Tyr Phe Arg Ala Asp Gly Glu Glu Cys Phe Gly Gly Gln Gly Val 
            260                 265                 270         
Phe Ser Gly Pro Gly Ser Tyr Met Lys Val Leu His Ser Leu Leu Lys 
        275                 280                 285             
Arg Asp Gly Leu Leu Leu Gln Pro Gln Thr Val Asp Leu Met Phe Gln 
    290                 295                 300                 
Pro Ala Leu Glu Pro Arg Leu Glu Glu Gln Met Asn Gln His Met Asp 
305                 310                 315                 320 
Ala Ser Pro His Ile Asn Tyr Gly Gly Pro Met Pro Met Val Leu Arg 
                325                 330                 335     
Arg Ser Phe Gly Leu Gly Gly Ile Ile Ala Leu Glu Asp Leu Asp Gly 
            340                 345                 350         
Glu Asn Trp Arg Arg Lys Gly Ser Met Thr Phe Gly Gly Gly Pro Asn 
        355                 360                 365             
Ile Val Trp Gln Ile Asp Pro Lys Ala Gly Leu Cys Thr Leu Ala Phe 
    370                 375                 380                 
Phe Gln Leu Glu Pro Trp Asn Asp Pro Val Cys Arg Asp Leu Thr Arg 
385                 390                 395                 400 
Thr Phe Glu His Ala Ile Tyr Ala Gln Tyr Gln Gln Gly             
                405                 410                         

 
<210> 5
<211> 1242
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of lovD
 
<400> 5
atgggttcta tcattgatgc ggctgcggcc gcggacccgg tggttctgat ggaaacggct 60
ttccgtaaag cggttaaaag ccgccagatt ccgggtgctg ttattatggc gcgtgattgt 120
agtggtaacc tgaactacac tcgctgtttc ggcgcacgca ctgtgcgtcg cgacgagtgc 180
aatcaattac caccgctgca ggtggataca ccatgtcgtc tggcaagcgc tactaaatta 240
ctgaccacga ttatggcact gcagtgcatg gaacgcggcc tggtagactt ggatgaaact 300
gttgaccgcc tgctgccgga cctgagcgcg atgccggtgc tggaaggctt tgatgatgcc 360
ggcaacccgc gtctgcgcga acgccgtggt aaaattacgt tacgccatct gctgacacac 420
accagcggtc tgtcgtacgt cttcctgcat ccgctgctgc gcgagtatat ggcccagggt 480
catttgcaga gcgctgagaa gtttggcatt cagtctcgtt ttgcgccgcc attagttaat 540
gatccaggcg cggaatggat ttatggcgct tctctggact gggcaggcaa attagtggaa 600
cgcgcaacgg gcttggacct ggaacagtac ttgcaggaga acatttgcgc gccgctgggc 660
atcactgata tgacgttcaa actgcagcag cgtccggata tgctggcacg tcgtgccgac 720
cagacccacc gcaactccag cgatggtcgt ctgcgctatg atgactctgt gtattttcgc 780
gcggacggtg aagagtgttt cgggggccag ggcgtgttca gcggtccagg cagttacatg 840
aaggttctgc actctctgct gaaacgtgac ggcctgttgc tgcagccaca aaccgtggat 900
ctgatgttcc agccggcgct ggaaccgcgc ttggaagaac aaatgaacca gcatatggac 960
gcgtcgccgc acatcaacta tggcggtcca atgcctatgg tcctgcgtcg cagcttcggc 1020
ctgggtggta tcattgcact ggaggatctg gatggtgaga actggcgtcg taaaggctcg 1080
atgacgtttg gtggcggtcc aaacattgtt tggcagattg acccgaaagc gggtctgtgt 1140
actttagcct ttttccagct ggaaccgtgg aacgacccgg tgtgtcgtga cctgactcgc 1200
acctttgagc acgcgatcta tgcacagtat caacagggct aa                    1242

 
<210> 6
<211> 413
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of lovD
 
<400> 6
Met Gly Ser Ile Ile Asp Ala Ala Ala Ala Ala Asp Pro Val Val Leu 
1               5                   10                  15      
Met Glu Thr Ala Phe Arg Lys Ala Val Lys Ser Arg Gln Ile Pro Gly 
            20                  25                  30          
Ala Val Ile Met Ala Arg Asp Cys Ser Gly Asn Leu Asn Tyr Thr Arg 
        35                  40                  45              
Cys Phe Gly Ala Arg Thr Val Arg Arg Asp Glu Cys Asn Gln Leu Pro 
    50                  55                  60                  
Pro Leu Gln Val Asp Thr Pro Cys Arg Leu Ala Ser Ala Thr Lys Leu 
65                  70                  75                  80  
Leu Thr Thr Ile Met Ala Leu Gln Cys Met Glu Arg Gly Leu Val Asp 
                85                  90                  95      
Leu Asp Glu Thr Val Asp Arg Leu Leu Pro Asp Leu Ser Ala Met Pro 
            100                 105                 110         
Val Leu Glu Gly Phe Asp Asp Ala Gly Asn Pro Arg Leu Arg Glu Arg 
        115                 120                 125             
Arg Gly Lys Ile Thr Leu Arg His Leu Leu Thr His Thr Ser Gly Leu 
    130                 135                 140                 
Ser Tyr Val Phe Leu His Pro Leu Leu Arg Glu Tyr Met Ala Gln Gly 
145                 150                 155                 160 
His Leu Gln Ser Ala Glu Lys Phe Gly Ile Gln Ser Arg Phe Ala Pro 
                165                 170                 175     
Pro Leu Val Asn Asp Pro Gly Ala Glu Trp Ile Tyr Gly Ala Ser Leu 
            180                 185                 190         
Asp Trp Ala Gly Lys Leu Val Glu Arg Ala Thr Gly Leu Asp Leu Glu 
        195                 200                 205             
Gln Tyr Leu Gln Glu Asn Ile Cys Ala Pro Leu Gly Ile Thr Asp Met 
    210                 215                 220                 
Thr Phe Lys Leu Gln Gln Arg Pro Asp Met Leu Ala Arg Arg Ala Asp 
225                 230                 235                 240 
Gln Thr His Arg Asn Ser Ser Asp Gly Arg Leu Arg Tyr Asp Asp Ser 
                245                 250                 255     
Val Tyr Phe Arg Ala Asp Gly Glu Glu Cys Phe Gly Gly Gln Gly Val 
            260                 265                 270         
Phe Ser Gly Pro Gly Ser Tyr Met Lys Val Leu His Ser Leu Leu Lys 
        275                 280                 285             
Arg Asp Gly Leu Leu Leu Gln Pro Gln Thr Val Asp Leu Met Phe Gln 
    290                 295                 300                 
Pro Ala Leu Glu Pro Arg Leu Glu Glu Gln Met Asn Gln His Met Asp 
305                 310                 315                 320 
Ala Ser Pro His Ile Asn Tyr Gly Gly Pro Met Pro Met Val Leu Arg 
                325                 330                 335     
Arg Ser Phe Gly Leu Gly Gly Ile Ile Ala Leu Glu Asp Leu Asp Gly 
            340                 345                 350         
Glu Asn Trp Arg Arg Lys Gly Ser Met Thr Phe Gly Gly Gly Pro Asn 
        355                 360                 365             
Ile Val Trp Gln Ile Asp Pro Lys Ala Gly Leu Cys Thr Leu Ala Phe 
    370                 375                 380                 
Phe Gln Leu Glu Pro Trp Asn Asp Pro Val Cys Arg Asp Leu Thr Arg 
385                 390                 395                 400 
Thr Phe Glu His Ala Ile Tyr Ala Gln Tyr Gln Gln Gly             
                405                 410                         

 
<210> 7
<211> 1242
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of lovD
 
<400> 7
atgggttcta tcattgatgc ggctgcggcc gcggacccgg tggttctgat ggaaacggct 60
ttccgtaaag cggttaaaag ccgccagatt ccgggtgctg ttattatggc gcgtgattgt 120
agtggtaacc tgaactacac tcgctgtttc ggcgcacgca ctgtgcgtcg cgacgagtgc 180
aatcaattac caccgctgca ggtggataca ccatgtcgtc tggcaagcgc tactaaatta 240
ctgaccacga ttatggcact gcagtgcatg gaacgcggcc tggtagactt ggatgaaact 300
gttgaccgcc tgctgccgga cctgagcgcg atgccggtgc tggaaggctt tgatgatgcc 360
ggcaacccgc gtctgcgcga acgccgtggt aaaattacgt tacgccatct gctgacacac 420
accagcggtc tgtcgtacgt cttcctgcat ccgctgctgc gcgagtatat ggcccagggt 480
catttgcaga gcgctgagaa gtttggcatt cagtctcgtt ttgcgccgcc attagttaat 540
gatccaggcg cggaatggat ttatggcgct tctctggact gggcaggcaa attagtggaa 600
cgcgcaacgg gcttggacct ggaacagtac ttgcaggaga acatttgcgc gccgctgggc 660
atcactgata tgacgttcaa actgcagcag cgtccggata tgctggcacg tcgtgccgac 720
cagacccacc gcaactccag cgatggtcgt ctgcgctatg atgactctgt gtattttcgc 780
gcggacggtg aagagtgttt cgggggccag ggcgtgttca gcagtccagg cagttacatg 840
aaggttctgc actctctgct gaaacgtgac ggcctgttgc tgcagccaca aaccgtggat 900
ctgatgttcc agccggcgct ggaaccgcgc ttggaagaac aaatgaacca gcatatggac 960
gcgtcgccgc acatcaacta tggcggtcca atgcctatgg tcctgcgtcg cagcttcggc 1020
ctgggtggta tcattgcact ggaggatctg gatggtgaga actggcgtcg taaaggctcg 1080
atgacgtttg gtggcggtcc aaacattgtt tggcagattg acccgaaagc gggtctgtgt 1140
actttagcct ttttccagct ggaaccgtgg aacgacccgg tgtgtcgtga cctgactcgc 1200
acctttgagc acgcgatcta tgcacagtat caacagggct aa                    1242

 
<210> 8
<211> 413
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of lovD
 
<400> 8
Met Gly Ser Ile Ile Asp Ala Ala Ala Ala Ala Asp Pro Val Val Leu 
1               5                   10                  15      
Met Glu Thr Ala Phe Arg Lys Ala Val Lys Ser Arg Gln Ile Pro Gly 
            20                  25                  30          
Ala Val Ile Met Ala Arg Asp Cys Ser Gly Asn Leu Asn Tyr Thr Arg 
        35                  40                  45              
Cys Phe Gly Ala Arg Thr Val Arg Arg Asp Glu Cys Asn Gln Leu Pro 
    50                  55                  60                  
Pro Leu Gln Val Asp Thr Pro Cys Arg Leu Ala Ser Ala Thr Lys Leu 
65                  70                  75                  80  
Leu Thr Thr Ile Met Ala Leu Gln Cys Met Glu Arg Gly Leu Val Asp 
                85                  90                  95      
Leu Asp Glu Thr Val Asp Arg Leu Leu Pro Asp Leu Ser Ala Met Pro 
            100                 105                 110         
Val Leu Glu Gly Phe Asp Asp Ala Gly Asn Pro Arg Leu Arg Glu Arg 
        115                 120                 125             
Arg Gly Lys Ile Thr Leu Arg His Leu Leu Thr His Thr Ser Gly Leu 
    130                 135                 140                 
Ser Tyr Val Phe Leu His Pro Leu Leu Arg Glu Tyr Met Ala Gln Gly 
145                 150                 155                 160 
His Leu Gln Ser Ala Glu Lys Phe Gly Ile Gln Ser Arg Phe Ala Pro 
                165                 170                 175     
Pro Leu Val Asn Asp Pro Gly Ala Glu Trp Ile Tyr Gly Ala Ser Leu 
            180                 185                 190         
Asp Trp Ala Gly Lys Leu Val Glu Arg Ala Thr Gly Leu Asp Leu Glu 
        195                 200                 205             
Gln Tyr Leu Gln Glu Asn Ile Cys Ala Pro Leu Gly Ile Thr Asp Met 
    210                 215                 220                 
Thr Phe Lys Leu Gln Gln Arg Pro Asp Met Leu Ala Arg Arg Ala Asp 
225                 230                 235                 240 
Gln Thr His Arg Asn Ser Ser Asp Gly Arg Leu Arg Tyr Asp Asp Ser 
                245                 250                 255     
Val Tyr Phe Arg Ala Asp Gly Glu Glu Cys Phe Gly Gly Gln Gly Val 
            260                 265                 270         
Phe Ser Ser Pro Gly Ser Tyr Met Lys Val Leu His Ser Leu Leu Lys 
        275                 280                 285             
Arg Asp Gly Leu Leu Leu Gln Pro Gln Thr Val Asp Leu Met Phe Gln 
    290                 295                 300                 
Pro Ala Leu Glu Pro Arg Leu Glu Glu Gln Met Asn Gln His Met Asp 
305                 310                 315                 320 
Ala Ser Pro His Ile Asn Tyr Gly Gly Pro Met Pro Met Val Leu Arg 
                325                 330                 335     
Arg Ser Phe Gly Leu Gly Gly Ile Ile Ala Leu Glu Asp Leu Asp Gly 
            340                 345                 350         
Glu Asn Trp Arg Arg Lys Gly Ser Met Thr Phe Gly Gly Gly Pro Asn 
        355                 360                 365             
Ile Val Trp Gln Ile Asp Pro Lys Ala Gly Leu Cys Thr Leu Ala Phe 
    370                 375                 380                 
Phe Gln Leu Glu Pro Trp Asn Asp Pro Val Cys Arg Asp Leu Thr Arg 
385                 390                 395                 400 
Thr Phe Glu His Ala Ile Tyr Ala Gln Tyr Gln Gln Gly             
                405                 410                         

 
<210> 9
<211> 1242
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of lovD
 
<400> 9
atgggttcta tcattgatgc ggctgcggcc gcggacccgg tggttctgat ggaaacggct 60
ttccgtaaag cggttaaaag ccgccagatt ccgggtgctg ttattatggc gcgtgattgt 120
agtggtaacc tgaactacac tcgctgtttc ggcgcacgca ctgtgcgtcg cgacgagtgc 180
aatcaattac caccgctgca ggtggataca ccatgtcgtc tggcaagcgc tactaaatta 240
ctgaccacga ttatggcact gcagtgcatg gaacgcggcc tggtagactt ggatgaaact 300
gttgaccgcc tgctgccgga cctgagcgcg atgccggtgc tggaaggctt tgatgatgcc 360
ggcaacccgc gtctgcgcga acgccgtggt aaaattacgt tacgccatct gctgacacac 420
accagcggtc tgtcgtacgt cttcctgcat ccgctgctgc gcgagtatgt tgcccagggt 480
catttgcaga gcgctgagaa gtttggcatt cagaatcgtt ttgcgccgcc attagttaat 540
gatccaggcg cggaatggat ttatggcgct tctctggact gggcaggcaa attagtggaa 600
cgcgcaacgg gcttggacct ggaacagtac ttgcaggaga acatttgcgc gccgctgggc 660
atcactgata tgacgttcaa actgcagcag cgtccggata tgctggcacg tcgtgccgac 720
cagacccacc gcaactccag cgatggtcgt ctgcgctatg atgactctgt gtattttcgc 780
gcggacggtg aagagtgttt cgggggccag ggcgtgttca gcagtccagg cagttacatg 840
aaggttctgc actctctgct gaaacgtgac ggcctgttgc tgcagccaca aaccgtggat 900
ctgatgttcc agccggcgct ggaaccgcgc ttggaagaac aaatgaacca gcatatggac 960
gcgtcgccgc acatcaacta tggcggtcca atgcctatgg tcctgcgtcg cagcttcggc 1020
ctgggtggta tcattgcact ggaggatctg gatggtgaga actggcgtcg taaaggctcg 1080
atgacgtttg gtggcggtcc aaacattgtt tggcagattg acccgaaagc gggtctgtgt 1140
actttagcct ttttccagct ggaaccgtgg aacgacccgg tgtgtcgtga cctgactcgc 1200
acctttgagc acgcgatcta tgcacagtat caacagggct aa                    1242

 
<210> 10
<211> 413
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of lovD
 
<400> 10
Met Gly Ser Ile Ile Asp Ala Ala Ala Ala Ala Asp Pro Val Val Leu 
1               5                   10                  15      
Met Glu Thr Ala Phe Arg Lys Ala Val Lys Ser Arg Gln Ile Pro Gly 
            20                  25                  30          
Ala Val Ile Met Ala Arg Asp Cys Ser Gly Asn Leu Asn Tyr Thr Arg 
        35                  40                  45              
Cys Phe Gly Ala Arg Thr Val Arg Arg Asp Glu Cys Asn Gln Leu Pro 
    50                  55                  60                  
Pro Leu Gln Val Asp Thr Pro Cys Arg Leu Ala Ser Ala Thr Lys Leu 
65                  70                  75                  80  
Leu Thr Thr Ile Met Ala Leu Gln Cys Met Glu Arg Gly Leu Val Asp 
                85                  90                  95      
Leu Asp Glu Thr Val Asp Arg Leu Leu Pro Asp Leu Ser Ala Met Pro 
            100                 105                 110         
Val Leu Glu Gly Phe Asp Asp Ala Gly Asn Pro Arg Leu Arg Glu Arg 
        115                 120                 125             
Arg Gly Lys Ile Thr Leu Arg His Leu Leu Thr His Thr Ser Gly Leu 
    130                 135                 140                 
Ser Tyr Val Phe Leu His Pro Leu Leu Arg Glu Tyr Val Ala Gln Gly 
145                 150                 155                 160 
His Leu Gln Ser Ala Glu Lys Phe Gly Ile Gln Asn Arg Phe Ala Pro 
                165                 170                 175     
Pro Leu Val Asn Asp Pro Gly Ala Glu Trp Ile Tyr Gly Ala Ser Leu 
            180                 185                 190         
Asp Trp Ala Gly Lys Leu Val Glu Arg Ala Thr Gly Leu Asp Leu Glu 
        195                 200                 205             
Gln Tyr Leu Gln Glu Asn Ile Cys Ala Pro Leu Gly Ile Thr Asp Met 
    210                 215                 220                 
Thr Phe Lys Leu Gln Gln Arg Pro Asp Met Leu Ala Arg Arg Ala Asp 
225                 230                 235                 240 
Gln Thr His Arg Asn Ser Ser Asp Gly Arg Leu Arg Tyr Asp Asp Ser 
                245                 250                 255     
Val Tyr Phe Arg Ala Asp Gly Glu Glu Cys Phe Gly Gly Gln Gly Val 
            260                 265                 270         
Phe Ser Ser Pro Gly Ser Tyr Met Lys Val Leu His Ser Leu Leu Lys 
        275                 280                 285             
Arg Asp Gly Leu Leu Leu Gln Pro Gln Thr Val Asp Leu Met Phe Gln 
    290                 295                 300                 
Pro Ala Leu Glu Pro Arg Leu Glu Glu Gln Met Asn Gln His Met Asp 
305                 310                 315                 320 
Ala Ser Pro His Ile Asn Tyr Gly Gly Pro Met Pro Met Val Leu Arg 
                325                 330                 335     
Arg Ser Phe Gly Leu Gly Gly Ile Ile Ala Leu Glu Asp Leu Asp Gly 
            340                 345                 350         
Glu Asn Trp Arg Arg Lys Gly Ser Met Thr Phe Gly Gly Gly Pro Asn 
        355                 360                 365             
Ile Val Trp Gln Ile Asp Pro Lys Ala Gly Leu Cys Thr Leu Ala Phe 
    370                 375                 380                 
Phe Gln Leu Glu Pro Trp Asn Asp Pro Val Cys Arg Asp Leu Thr Arg 
385                 390                 395                 400 
Thr Phe Glu His Ala Ile Tyr Ala Gln Tyr Gln Gln Gly             
                405                 410                         

 
<210> 11
<211> 1242
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of lovD
 
<400> 11
atgggttcta tcattgatgc ggctgtggcc gcggacccgg tggttctgat ggaaacggct 60
ttccgtaaag cggttgaaag ccgccagatt ccgggtgctg ttattatggc gcgtgattgt 120
agtggtaacc tgaactacac tcgctgtttc ggcgcacgca ctgtgcgtcg cgacgagtgc 180
aatcaattac caccgctgca ggtggataca ccatgtcgtc tggcaagcgc tactaaatta 240
ctgaccacga ttatggcact gcagtgcatg gaacgcggcc tggtagactt ggatgaaact 300
gttgaccgcc tgctgccgga cctgagcgcg atgccggtgc tggaaggctt tgatgatgcc 360
ggcaacccgc gtctgcgcga acgccgtggt aaaattacgt tacgccatct gctgacacac 420
accagcggtc tgtcgtacgt cttcctgcat ccgctgctgc gcgagtatgt tgcccagggt 480
catttgcaga gcgctgagaa gtttggcatt cagaatcgtt ttgcgccgcc attagttaat 540
gatccaggcg cggaatggat ttatggcgct tctatcgact gggcaggcaa attagtggaa 600
cgcgcaacgg gcttggacct ggaacagtac ttgcaggaga acatttgcgc gccgctgggc 660
atcactgata tgacgttcaa actgcagcag cgtccggata tgctggcacg tcgtgccgac 720
cagacccacc gcaactccag cgatggtaaa ctgcgctatg atgactctgt gtattttcgc 780
gcggacggtg aagagtgttt cgggggccag ggcgtgttca gcagtccagg cagttacatg 840
aaggttctgc actctctgct gaaacgtgac ggcctgttgc tgcagccaga aaccgtggat 900
ctgatgttcc agccggcgct ggaaccgcgc ttggaagaac aaatgaacca gcatatggac 960
gcgtcgccgc acatcaacta tggcggtcca atgcctatgg tcctgcgtcg cagcttcggc 1020
ctgggtggta tcattgcact ggaggatctg gatggtgaga actggcgtcg taaaggctcg 1080
atgacgtttg gtggcggtcc aaacattgtt tggcagattg acccgaaagc gggtctgtgt 1140
actttagtct ttttccagct ggaaccgtgg aacgacccgg tgtgtcgtga cctgactcgc 1200
acctttgagc acgcgatcta tgcacagtat caacagggct aa                    1242

 
<210> 12
<211> 413
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of lovD
 
<400> 12
Met Gly Ser Ile Ile Asp Ala Ala Val Ala Ala Asp Pro Val Val Leu 
1               5                   10                  15      
Met Glu Thr Ala Phe Arg Lys Ala Val Glu Ser Arg Gln Ile Pro Gly 
            20                  25                  30          
Ala Val Ile Met Ala Arg Asp Cys Ser Gly Asn Leu Asn Tyr Thr Arg 
        35                  40                  45              
Cys Phe Gly Ala Arg Thr Val Arg Arg Asp Glu Cys Asn Gln Leu Pro 
    50                  55                  60                  
Pro Leu Gln Val Asp Thr Pro Cys Arg Leu Ala Ser Ala Thr Lys Leu 
65                  70                  75                  80  
Leu Thr Thr Ile Met Ala Leu Gln Cys Met Glu Arg Gly Leu Val Asp 
                85                  90                  95      
Leu Asp Glu Thr Val Asp Arg Leu Leu Pro Asp Leu Ser Ala Met Pro 
            100                 105                 110         
Val Leu Glu Gly Phe Asp Asp Ala Gly Asn Pro Arg Leu Arg Glu Arg 
        115                 120                 125             
Arg Gly Lys Ile Thr Leu Arg His Leu Leu Thr His Thr Ser Gly Leu 
    130                 135                 140                 
Ser Tyr Val Phe Leu His Pro Leu Leu Arg Glu Tyr Val Ala Gln Gly 
145                 150                 155                 160 
His Leu Gln Ser Ala Glu Lys Phe Gly Ile Gln Asn Arg Phe Ala Pro 
                165                 170                 175     
Pro Leu Val Asn Asp Pro Gly Ala Glu Trp Ile Tyr Gly Ala Ser Ile 
            180                 185                 190         
Asp Trp Ala Gly Lys Leu Val Glu Arg Ala Thr Gly Leu Asp Leu Glu 
        195                 200                 205             
Gln Tyr Leu Gln Glu Asn Ile Cys Ala Pro Leu Gly Ile Thr Asp Met 
    210                 215                 220                 
Thr Phe Lys Leu Gln Gln Arg Pro Asp Met Leu Ala Arg Arg Ala Asp 
225                 230                 235                 240 
Gln Thr His Arg Asn Ser Ser Asp Gly Lys Leu Arg Tyr Asp Asp Ser 
                245                 250                 255     
Val Tyr Phe Arg Ala Asp Gly Glu Glu Cys Phe Gly Gly Gln Gly Val 
            260                 265                 270         
Phe Ser Ser Pro Gly Ser Tyr Met Lys Val Leu His Ser Leu Leu Lys 
        275                 280                 285             
Arg Asp Gly Leu Leu Leu Gln Pro Glu Thr Val Asp Leu Met Phe Gln 
    290                 295                 300                 
Pro Ala Leu Glu Pro Arg Leu Glu Glu Gln Met Asn Gln His Met Asp 
305                 310                 315                 320 
Ala Ser Pro His Ile Asn Tyr Gly Gly Pro Met Pro Met Val Leu Arg 
                325                 330                 335     
Arg Ser Phe Gly Leu Gly Gly Ile Ile Ala Leu Glu Asp Leu Asp Gly 
            340                 345                 350         
Glu Asn Trp Arg Arg Lys Gly Ser Met Thr Phe Gly Gly Gly Pro Asn 
        355                 360                 365             
Ile Val Trp Gln Ile Asp Pro Lys Ala Gly Leu Cys Thr Leu Val Phe 
    370                 375                 380                 
Phe Gln Leu Glu Pro Trp Asn Asp Pro Val Cys Arg Asp Leu Thr Arg 
385                 390                 395                 400 
Thr Phe Glu His Ala Ile Tyr Ala Gln Tyr Gln Gln Gly             
                405                 410                         

 
<210> 13
<211> 1242
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of lovD
 
<400> 13
atgggttcta tcattgatgc ggctgtggcc gcggacccgg tggttctgat ggaaacggct 60
ttccgtaaag cggttgaaag ccgccagatt ccgggtgctg ttattatggc gcgtgattgt 120
agtggtcgtc tgaactacac tcgctgtttc ggcgcacgca ctgtgcgtcg cgacgagtgc 180
aatcaattac caccgctgca ggtggataca ccatgtcgtc tggcaagcgc tactaaatta 240
ctgaccacga ttatggcact gcagtgcatg gaacgcggcc tggtagactt ggatgaaact 300
gttgaccgcc tgctgccgga cctgagcgcg atgccggtgc tggaaggctt tgatgatgcc 360
ggcaacccgc gtctgcgcga acgccgtggt aaaattacgt tacgccatct gctgacacac 420
accagcggtc tgtcgtacgt cttcctgcat ccgctgctgc gcgagtatgt tgcccagggt 480
catttgcagg gcgctgagaa gtttggcatt cagaatcgtt ttgcgccgcc attagttaat 540
gatccaggcg cggaatggat ttatggcgct ggcatcgact gggcaggcaa attagtggaa 600
cgcgcaacgg gcttggacct ggaacagtac ttgcaggaga acatttgcgc gccgctgggc 660
atcactgata tgacgttcaa actgcagcag cgtccggata tgctggcacg tcgtgccgac 720
atgacccacc gcaactccag cgatggtaaa ctgcgctatg atgactctgt gtattttcgc 780
gcggacggtg aagagtgttt cgggggccag ggcgtgttca gcagtccagg cagttacatg 840
aaggttctgc actctctgct gaaacgtgac ggcctgttgc tgcagccaga aaccgtggat 900
ctgatgttcc agccggcgct ggaaccgcgc ttggaagaac aaatgaacca gcatatggac 960
gcgtcgccgc acatcaacta tggcggtcca atgcctatgg tcctgcgtcg cagcttcggc 1020
ctgggtggta tcattgcact ggaggatctg gatggtgaga actggcgtcg taaaggctcg 1080
atgacgtttg gtggcggtcc aaacattatt tggcagattg acccgaaagc gggtctgtgt 1140
actttagtct ttttccagct ggaaccgtgg aacgacccgg tgtgtcgtga cctgactcgc 1200
acctttgaga aagcgatcta tgcacagtat caacagggct aa                    1242

 
<210> 14
<211> 413
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of lovD
 
<400> 14
Met Gly Ser Ile Ile Asp Ala Ala Val Ala Ala Asp Pro Val Val Leu 
1               5                   10                  15      
Met Glu Thr Ala Phe Arg Lys Ala Val Glu Ser Arg Gln Ile Pro Gly 
            20                  25                  30          
Ala Val Ile Met Ala Arg Asp Cys Ser Gly Arg Leu Asn Tyr Thr Arg 
        35                  40                  45              
Cys Phe Gly Ala Arg Thr Val Arg Arg Asp Glu Cys Asn Gln Leu Pro 
    50                  55                  60                  
Pro Leu Gln Val Asp Thr Pro Cys Arg Leu Ala Ser Ala Thr Lys Leu 
65                  70                  75                  80  
Leu Thr Thr Ile Met Ala Leu Gln Cys Met Glu Arg Gly Leu Val Asp 
                85                  90                  95      
Leu Asp Glu Thr Val Asp Arg Leu Leu Pro Asp Leu Ser Ala Met Pro 
            100                 105                 110         
Val Leu Glu Gly Phe Asp Asp Ala Gly Asn Pro Arg Leu Arg Glu Arg 
        115                 120                 125             
Arg Gly Lys Ile Thr Leu Arg His Leu Leu Thr His Thr Ser Gly Leu 
    130                 135                 140                 
Ser Tyr Val Phe Leu His Pro Leu Leu Arg Glu Tyr Val Ala Gln Gly 
145                 150                 155                 160 
His Leu Gln Gly Ala Glu Lys Phe Gly Ile Gln Asn Arg Phe Ala Pro 
                165                 170                 175     
Pro Leu Val Asn Asp Pro Gly Ala Glu Trp Ile Tyr Gly Ala Gly Ile 
            180                 185                 190         
Asp Trp Ala Gly Lys Leu Val Glu Arg Ala Thr Gly Leu Asp Leu Glu 
        195                 200                 205             
Gln Tyr Leu Gln Glu Asn Ile Cys Ala Pro Leu Gly Ile Thr Asp Met 
    210                 215                 220                 
Thr Phe Lys Leu Gln Gln Arg Pro Asp Met Leu Ala Arg Arg Ala Asp 
225                 230                 235                 240 
Met Thr His Arg Asn Ser Ser Asp Gly Lys Leu Arg Tyr Asp Asp Ser 
                245                 250                 255     
Val Tyr Phe Arg Ala Asp Gly Glu Glu Cys Phe Gly Gly Gln Gly Val 
            260                 265                 270         
Phe Ser Ser Pro Gly Ser Tyr Met Lys Val Leu His Ser Leu Leu Lys 
        275                 280                 285             
Arg Asp Gly Leu Leu Leu Gln Pro Glu Thr Val Asp Leu Met Phe Gln 
    290                 295                 300                 
Pro Ala Leu Glu Pro Arg Leu Glu Glu Gln Met Asn Gln His Met Asp 
305                 310                 315                 320 
Ala Ser Pro His Ile Asn Tyr Gly Gly Pro Met Pro Met Val Leu Arg 
                325                 330                 335     
Arg Ser Phe Gly Leu Gly Gly Ile Ile Ala Leu Glu Asp Leu Asp Gly 
            340                 345                 350         
Glu Asn Trp Arg Arg Lys Gly Ser Met Thr Phe Gly Gly Gly Pro Asn 
        355                 360                 365             
Ile Ile Trp Gln Ile Asp Pro Lys Ala Gly Leu Cys Thr Leu Val Phe 
    370                 375                 380                 
Phe Gln Leu Glu Pro Trp Asn Asp Pro Val Cys Arg Asp Leu Thr Arg 
385                 390                 395                 400 
Thr Phe Glu Lys Ala Ile Tyr Ala Gln Tyr Gln Gln Gly             
                405                 410                         

 
<210> 15
<211> 1242
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of lovD
 
<400> 15
atgggttcta tcattgatgc ggctgtggcc gcggacccgg tggttctgat ggaaacggct 60
ttccgtaaag cggttgaaag ccgccagatt ccgggtgctg ttattatggc gcgtgattgt 120
agcggtcgtc tgaactacac tcgctgtttc ggcgcacgca ctgtgcgtcg cgacgagtgc 180
aatcaattac caccgctgca ggtggataca ccatgtcgtc tggcaagcgc tactaaatta 240
ctgaccacga ttatggcact gcagtgcatg gaacgcggcc tggtagactt ggatgaaact 300
gttgaccgcc tgctgccgga cctgagcgcg atgccggtgc tggaaggctt tgatgatgcc 360
ggcaacccgc gtctgcgcga acgccgtggt aaaattacgt tacgccatct gctgacacac 420
accagcggtc tgtcgtacgt cttcctgcat ccgctgctgc gcgagtatgt tgcccagggt 480
catttgcagg gcgctgagaa gtttggcatt cagaatcgtt ttgcgccgcc attagttaat 540
gatccaggcg cggaatggat ttatggcgct ggcatcgact gggcaggcaa attagtggaa 600
cgcgcaacgg gcttggacct ggaacagtac ttgcaggaga acatttgcgc gccgctgggc 660
atcactgata tgacgttcaa actgcagcag cgcccggata tgctggcacg tcgtgccgac 720
atgacccacc gcaactccag cgatggtaaa ctgcgctatg atgacacggt gtattttcgc 780
gttgacggtg aagagtgttt cgggggccag ggcgtgttca gcagtccagg cagttacatg 840
aaggttctgc actctctgct gaaacgtgac ggcctgttgc tgcagccagg gaccgtggat 900
ctgatgttcc agccggcgct ggaaccgcgc ttggaagaac aaatgaacca gcatatggac 960
gcgtcgccgc acatcaacta tggcggtcca atgcctatgg tcctgcgtcg cagcttcggc 1020
ctgggtggta tcattgcact ggaggatctg gatggtgaga actggcgtcg taaaggctcg 1080
atgacgtttg gtggcggtcc aaacattatt tggcagattg acccgaaagc gggtctgtgt 1140
actttagtct ttttccagct ggaaccgtgg agtgacccgg tgtgtcgtga cctgactcgc 1200
acctttgaga aagcgatcta tgcacagtat caacagggct aa                    1242

 
<210> 16
<211> 413
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of lovD
 
<400> 16
Met Gly Ser Ile Ile Asp Ala Ala Val Ala Ala Asp Pro Val Val Leu 
1               5                   10                  15      
Met Glu Thr Ala Phe Arg Lys Ala Val Glu Ser Arg Gln Ile Pro Gly 
            20                  25                  30          
Ala Val Ile Met Ala Arg Asp Cys Ser Gly Arg Leu Asn Tyr Thr Arg 
        35                  40                  45              
Cys Phe Gly Ala Arg Thr Val Arg Arg Asp Glu Cys Asn Gln Leu Pro 
    50                  55                  60                  
Pro Leu Gln Val Asp Thr Pro Cys Arg Leu Ala Ser Ala Thr Lys Leu 
65                  70                  75                  80  
Leu Thr Thr Ile Met Ala Leu Gln Cys Met Glu Arg Gly Leu Val Asp 
                85                  90                  95      
Leu Asp Glu Thr Val Asp Arg Leu Leu Pro Asp Leu Ser Ala Met Pro 
            100                 105                 110         
Val Leu Glu Gly Phe Asp Asp Ala Gly Asn Pro Arg Leu Arg Glu Arg 
        115                 120                 125             
Arg Gly Lys Ile Thr Leu Arg His Leu Leu Thr His Thr Ser Gly Leu 
    130                 135                 140                 
Ser Tyr Val Phe Leu His Pro Leu Leu Arg Glu Tyr Val Ala Gln Gly 
145                 150                 155                 160 
His Leu Gln Gly Ala Glu Lys Phe Gly Ile Gln Asn Arg Phe Ala Pro 
                165                 170                 175     
Pro Leu Val Asn Asp Pro Gly Ala Glu Trp Ile Tyr Gly Ala Gly Ile 
            180                 185                 190         
Asp Trp Ala Gly Lys Leu Val Glu Arg Ala Thr Gly Leu Asp Leu Glu 
        195                 200                 205             
Gln Tyr Leu Gln Glu Asn Ile Cys Ala Pro Leu Gly Ile Thr Asp Met 
    210                 215                 220                 
Thr Phe Lys Leu Gln Gln Arg Pro Asp Met Leu Ala Arg Arg Ala Asp 
225                 230                 235                 240 
Met Thr His Arg Asn Ser Ser Asp Gly Lys Leu Arg Tyr Asp Asp Thr 
                245                 250                 255     
Val Tyr Phe Arg Val Asp Gly Glu Glu Cys Phe Gly Gly Gln Gly Val 
            260                 265                 270         
Phe Ser Ser Pro Gly Ser Tyr Met Lys Val Leu His Ser Leu Leu Lys 
        275                 280                 285             
Arg Asp Gly Leu Leu Leu Gln Pro Gly Thr Val Asp Leu Met Phe Gln 
    290                 295                 300                 
Pro Ala Leu Glu Pro Arg Leu Glu Glu Gln Met Asn Gln His Met Asp 
305                 310                 315                 320 
Ala Ser Pro His Ile Asn Tyr Gly Gly Pro Met Pro Met Val Leu Arg 
                325                 330                 335     
Arg Ser Phe Gly Leu Gly Gly Ile Ile Ala Leu Glu Asp Leu Asp Gly 
            340                 345                 350         
Glu Asn Trp Arg Arg Lys Gly Ser Met Thr Phe Gly Gly Gly Pro Asn 
        355                 360                 365             
Ile Ile Trp Gln Ile Asp Pro Lys Ala Gly Leu Cys Thr Leu Val Phe 
    370                 375                 380                 
Phe Gln Leu Glu Pro Trp Ser Asp Pro Val Cys Arg Asp Leu Thr Arg 
385                 390                 395                 400 
Thr Phe Glu Lys Ala Ile Tyr Ala Gln Tyr Gln Gln Gly             
                405                 410                         

 
<210> 17
<211> 1242
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of lovD
 
<400> 17
atgggttcta acattgatgc ggctgtggcc gcggacccgg tggttctgat ggaaacggct 60
ttccgtaaag cggttgaaag ctctcagatt ccgggtgctg ttattatggc gcgtgattgt 120
agcggtcgtc tgaactacac tcgctgtttc ggcgcacgca ctgtgcgtcg cgacgagtgc 180
aatcaattac caccgctgca ggtggataca ccatgtcgtc tggcaagcgc tactaaatta 240
ctgaccacga ttatggcact gcagtgcatg gaacgcggcc tggtagactt ggatgaaact 300
gttgaccgcc tgctgccgga cctgagcgcg atgccggtgc tggaaggctt tgatgatgcc 360
ggcaacccgc gtctgcgcga acgccgtggt aaaattacgt tacgccatct gctgacacac 420
accagcggtc tgtcgtacgt cttcctgcat ccgctgctgc gcgagtatgt tgcccagggt 480
catttgcagg gcgctgagaa gtttggcatt cagaatcgtt ttgcgccgcc attagttaat 540
gatccaggcg cggaatggat ttatggcgct ggcatcgact gggcaggcaa attagtggaa 600
cgcgcaacgg gcttggacct ggaacagtac ttgcaggaga acatttgcgc gccgctgggc 660
atcactgata tgacgttcaa actgcagcag cgcccggata tgctggcacg tcgtgccgac 720
atgacccacc gcaactccag cgatggtaaa ctgcgctatg atgacacggt gtattttcgc 780
catgacggtg aagagtgttt cgggggccag ggcgtgttca gcagtccagg cagttacatg 840
aaggttctgc actctctgct gaaacgtgac ggcctgttgc tgcagccagg gaccgtggat 900
ctgatgttcc agccggcgct ggaaccgcgt ttggaagaac aaatgaacca gcatatggac 960
gcgtcgccgc acatcaacta tggcggtcca atgcctatgg tcctgcgtcg cagcttcggc 1020
ctgggtggta tcattgcact ggaggatctg gatggtgaga actggcgtcg taaaggctcg 1080
atgacgtttg gtggcggtcc aaacattatt tggcagattg acccgaaagc gggtctgtgt 1140
actttagtct ttttccagct ggaaccgtgg agtgacccgg tgtgtcgtga cctgactcgc 1200
acctttgaga aagcgatcta tgcacagtat caacagggct aa                    1242

 
<210> 18
<211> 413
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of lovD
 
<400> 18
Met Gly Ser Asn Ile Asp Ala Ala Val Ala Ala Asp Pro Val Val Leu 
1               5                   10                  15      
Met Glu Thr Ala Phe Arg Lys Ala Val Glu Ser Ser Gln Ile Pro Gly 
            20                  25                  30          
Ala Val Ile Met Ala Arg Asp Cys Ser Gly Arg Leu Asn Tyr Thr Arg 
        35                  40                  45              
Cys Phe Gly Ala Arg Thr Val Arg Arg Asp Glu Cys Asn Gln Leu Pro 
    50                  55                  60                  
Pro Leu Gln Val Asp Thr Pro Cys Arg Leu Ala Ser Ala Thr Lys Leu 
65                  70                  75                  80  
Leu Thr Thr Ile Met Ala Leu Gln Cys Met Glu Arg Gly Leu Val Asp 
                85                  90                  95      
Leu Asp Glu Thr Val Asp Arg Leu Leu Pro Asp Leu Ser Ala Met Pro 
            100                 105                 110         
Val Leu Glu Gly Phe Asp Asp Ala Gly Asn Pro Arg Leu Arg Glu Arg 
        115                 120                 125             
Arg Gly Lys Ile Thr Leu Arg His Leu Leu Thr His Thr Ser Gly Leu 
    130                 135                 140                 
Ser Tyr Val Phe Leu His Pro Leu Leu Arg Glu Tyr Val Ala Gln Gly 
145                 150                 155                 160 
His Leu Gln Gly Ala Glu Lys Phe Gly Ile Gln Asn Arg Phe Ala Pro 
                165                 170                 175     
Pro Leu Val Asn Asp Pro Gly Ala Glu Trp Ile Tyr Gly Ala Gly Ile 
            180                 185                 190         
Asp Trp Ala Gly Lys Leu Val Glu Arg Ala Thr Gly Leu Asp Leu Glu 
        195                 200                 205             
Gln Tyr Leu Gln Glu Asn Ile Cys Ala Pro Leu Gly Ile Thr Asp Met 
    210                 215                 220                 
Thr Phe Lys Leu Gln Gln Arg Pro Asp Met Leu Ala Arg Arg Ala Asp 
225                 230                 235                 240 
Met Thr His Arg Asn Ser Ser Asp Gly Lys Leu Arg Tyr Asp Asp Thr 
                245                 250                 255     
Val Tyr Phe Arg His Asp Gly Glu Glu Cys Phe Gly Gly Gln Gly Val 
            260                 265                 270         
Phe Ser Ser Pro Gly Ser Tyr Met Lys Val Leu His Ser Leu Leu Lys 
        275                 280                 285             
Arg Asp Gly Leu Leu Leu Gln Pro Gly Thr Val Asp Leu Met Phe Gln 
    290                 295                 300                 
Pro Ala Leu Glu Pro Arg Leu Glu Glu Gln Met Asn Gln His Met Asp 
305                 310                 315                 320 
Ala Ser Pro His Ile Asn Tyr Gly Gly Pro Met Pro Met Val Leu Arg 
                325                 330                 335     
Arg Ser Phe Gly Leu Gly Gly Ile Ile Ala Leu Glu Asp Leu Asp Gly 
            340                 345                 350         
Glu Asn Trp Arg Arg Lys Gly Ser Met Thr Phe Gly Gly Gly Pro Asn 
        355                 360                 365             
Ile Ile Trp Gln Ile Asp Pro Lys Ala Gly Leu Cys Thr Leu Val Phe 
    370                 375                 380                 
Phe Gln Leu Glu Pro Trp Ser Asp Pro Val Cys Arg Asp Leu Thr Arg 
385                 390                 395                 400 
Thr Phe Glu Lys Ala Ile Tyr Ala Gln Tyr Gln Gln Gly             
                405                 410                         

 
<210> 19
<211> 1242
<212> DNA
<213> Artificial Sequence
 
<220>
<223> Variant of lovD
 
<400> 19
atgggttcta acattgatgc ggctgtggcc gcggacccgg tggttctgat ggaaacggct 60
ttccgtaaag cggttgaaag ctctcagatt ccgggtgctg ttttgatggc gcgtgattgt 120
agcggtcgtc tgaactacac tcgctgtttc ggcgcacgca ctgtgcgtcg cgacgagtgc 180
aatcaattac caccgctgca ggtggataca ccatgtcgtc tggcaagcgc tactaaatta 240
ctgaccacga ttatggcact gcagtgcatg gaacgcggcc tggtacgctt ggatgaaact 300
gttgaccgcc tgctgccgga cctgtgcgcg atgccggtgc tggaaggctt tgatgatgcc 360
ggcaacccgc gtctgcgcga acgccgtggt aaaattacgt tacgccatct gctgacacac 420
accagcggtc tgtcgtacgt cttcctgcat ccgctgctgc gcgagtatgt tgcccagggt 480
catttgcagg gcgctgagaa gtttggcatt cagaatcgtt ttgcgccgcc attagttaat 540
gatccaggcg cggaatggat ttatggcgct ggcatcgact gggcaggcaa attagtggaa 600
cgcgcaacgg gcttggacct ggaacagtac ttgcaggaga acatttgcgc gccgctgggc 660
atcactgata tgacgttcaa actgcagcag cgcccggata tgctggcacg tcgtgccgac 720
atgacccacc gcaactccag cgatggtaaa ctgcgctatg atgacacggt gtattttcgc 780
catgacggtg aagagtgttt cgggggccag ggcgtgttca gcagtccagg cagttacatg 840
aaggttctgc actctctgct gaaacgtgac ggcctgttgc tgcagccagg gaccgtggat 900
ctgatgttcc agccggcgct ggaaccgcgt ttggaagaac aaatgaacca gcatatggac 960
gcgtcgccgc acatcaacta tggcggtcca atgcctatgg tcatgcgtcg cagcttcggc 1020
ctgggtggta tcattgcact ggaggatctg gatggtgaga actggcgtcg taaaggctcg 1080
atgacgtttg gtggcggtcc aaacattatt tggcagattg acccgaaagc gggtctgtgt 1140
actttagtct ttttccagct ggaaccgtgg agtgacccgg tgtgtcgtga cctgactcgc 1200
acctttgaga aagcgatcta tgcacagtat caacagggct aa                    1242

 
<210> 20
<211> 413
<212> PRT
<213> Artificial Sequence
 
<220>
<223> Variant of lovD
 
<400> 20
Met Gly Ser Asn Ile Asp Ala Ala Val Ala Ala Asp Pro Val Val Leu 
1               5                   10                  15      
Met Glu Thr Ala Phe Arg Lys Ala Val Glu Ser Ser Gln Ile Pro Gly 
            20                  25                  30          
Ala Val Leu Met Ala Arg Asp Cys Ser Gly Arg Leu Asn Tyr Thr Arg 
        35                  40                  45              
Cys Phe Gly Ala Arg Thr Val Arg Arg Asp Glu Cys Asn Gln Leu Pro 
    50                  55                  60                  
Pro Leu Gln Val Asp Thr Pro Cys Arg Leu Ala Ser Ala Thr Lys Leu 
65                  70                  75                  80  
Leu Thr Thr Ile Met Ala Leu Gln Cys Met Glu Arg Gly Leu Val Arg 
                85                  90                  95      
Leu Asp Glu Thr Val Asp Arg Leu Leu Pro Asp Leu Cys Ala Met Pro 
            100                 105                 110         
Val Leu Glu Gly Phe Asp Asp Ala Gly Asn Pro Arg Leu Arg Glu Arg 
        115                 120                 125             
Arg Gly Lys Ile Thr Leu Arg His Leu Leu Thr His Thr Ser Gly Leu 
    130                 135                 140                 
Ser Tyr Val Phe Leu His Pro Leu Leu Arg Glu Tyr Val Ala Gln Gly 
145                 150                 155                 160 
His Leu Gln Gly Ala Glu Lys Phe Gly Ile Gln Asn Arg Phe Ala Pro 
                165                 170                 175     
Pro Leu Val Asn Asp Pro Gly Ala Glu Trp Ile Tyr Gly Ala Gly Ile 
            180                 185                 190         
Asp Trp Ala Gly Lys Leu Val Glu Arg Ala Thr Gly Leu Asp Leu Glu 
        195                 200                 205             
Gln Tyr Leu Gln Glu Asn Ile Cys Ala Pro Leu Gly Ile Thr Asp Met 
    210                 215                 220                 
Thr Phe Lys Leu Gln Gln Arg Pro Asp Met Leu Ala Arg Arg Ala Asp 
225                 230                 235                 240 
Met Thr His Arg Asn Ser Ser Asp Gly Lys Leu Arg Tyr Asp Asp Thr 
                245                 250                 255     
Val Tyr Phe Arg His Asp Gly Glu Glu Cys Phe Gly Gly Gln Gly Val 
            260                 265                 270         
Phe Ser Ser Pro Gly Ser Tyr Met Lys Val Leu His Ser Leu Leu Lys 
        275                 280                 285             
Arg Asp Gly Leu Leu Leu Gln Pro Gly Thr Val Asp Leu Met Phe Gln 
    290                 295                 300                 
Pro Ala Leu Glu Pro Arg Leu Glu Glu Gln Met Asn Gln His Met Asp 
305                 310                 315                 320 
Ala Ser Pro His Ile Asn Tyr Gly Gly Pro Met Pro Met Val Met Arg 
                325                 330                 335     
Arg Ser Phe Gly Leu Gly Gly Ile Ile Ala Leu Glu Asp Leu Asp Gly 
            340                 345                 350         
Glu Asn Trp Arg Arg Lys Gly Ser Met Thr Phe Gly Gly Gly Pro Asn 
        355                 360                 365             
Ile Ile Trp Gln Ile Asp Pro Lys Ala Gly Leu Cys Thr Leu Val Phe 
    370                 375                 380                 
Phe Gln Leu Glu Pro Trp Ser Asp Pro Val Cys Arg Asp Leu Thr Arg 
385                 390                 395                 400 
Thr Phe Glu Lys Ala Ile Tyr Ala Gln Tyr Gln Gln Gly             
                405                 410                         

