                         SEQUENCE LISTING

<110>  Codexis, Inc.
       Newman, Lisa M.
       Clark, Louis
       Ching, Charlene
       Zimmerman, Sabrina
 
<120>  Carbonic Anhydrase Polypeptides and Uses Thereof

<130>  CX4-009WO2

<150>  PCT/US10/20507
<151>  2010-01-08

<150>  12/684,800
<151>  2010-01-08

<150>  61/247,315
<151>  2009-09-30

<160>  362   

<170>  PatentIn version 3.5

<210>  1
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  codon optimized M. thermophila carbonic anhydrase gene

<400>  1
atgcaggaaa taaccgtgga tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aaagaaactt ca                         642


<210>  2
<211>  214
<212>  PRT
<213>  Methanosarcina thermophila

<400>  2

Met Gln Glu Ile Thr Val Asp Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Glu Thr Ser 
    210                 


<210>  3
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  3
atgcaggaaa taaccgtgga tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aagaaacttc ataaggccaa actggccacc      660

atcaccatca ccattaggga agagcagatg ggcaagcttg acctg                      705


<210>  4
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  4

Met Gln Glu Ile Thr Val Asp Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr 
    210                 215                 220                 


Ile Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 235 


<210>  5
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  5
atgcaggaaa taaccgtgga tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggctgta      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc agtcattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaaaaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aaagaaactt ca                         642


<210>  6
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  6

Met Gln Glu Ile Thr Val Asp Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Val Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Val Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Lys Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Glu Thr Ser 
    210                 


<210>  7
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  7
atgcaggaaa taaccgtgga tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggctgta      120

gtcataggag aggtgacaat aggtgccaac gttatggttt ccccctgcgc agtcattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggcgttgta      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aaagaaactt ca                         642


<210>  8
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  8

Met Gln Glu Ile Thr Val Asp Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Val Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Cys Ala Val Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Glu Thr Ser 
    210                 


<210>  9
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  9
atgcaggaaa taaccgtgga tgagttttcg aacatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt ccccccatgc atccattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aaagaaactt ca                         642


<210>  10
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  10

Met Gln Glu Ile Thr Val Asp Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro His Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Glu Thr Ser 
    210                 


<210>  11
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  11
atgcaggaaa taaccgtgga tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggctgta      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc agtcattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aaagaaactt ca                         642


<210>  12
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  12

Met Gln Glu Ile Thr Val Asp Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Val Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Val Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Glu Thr Ser 
    210                 


<210>  13
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  13
atgcaggaaa taaccgtgga tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt ccccccatgc agtcattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aaagaaactt ca                         642


<210>  14
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  14

Met Gln Glu Ile Thr Val Asp Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro His Ala Val Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Glu Thr Ser 
    210                 


<210>  15
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  15
atgcaggaaa taaccgtgga tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt ccccccatgc atccattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aaagaaactt ca                         642


<210>  16
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  16

Met Gln Glu Ile Thr Val Asp Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro His Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Glu Thr Ser 
    210                 


<210>  17
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  17
atgcaggaaa taaccgtgga tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggctgta      120

gtcataggag aggtgacaat aggtgccaac gttatggttt ccccctgcgc agtcattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aaagaaactt ca                         642


<210>  18
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  18

Met Gln Glu Ile Thr Val Asp Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Val Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Cys Ala Val Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Glu Thr Ser 
    210                 


<210>  19
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  19
atgcaggaaa taaccgtgga tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt ccccccatgc atccattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaac aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc acactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aaagaaactt ca                         642


<210>  20
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  20

Met Gln Glu Ile Thr Val Asp Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro His Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Thr Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Glu Thr Ser 
    210                 


<210>  21
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  21
atgcaggaaa taaccgtgga tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt ccccccatgc atccattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aaaggaactt ca                         642


<210>  22
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  22

Met Gln Glu Ile Thr Val Asp Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro His Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Gly Thr Ser 
    210                 


<210>  23
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  23
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aagaaacttc ataaggccaa actggccacc      660

atcaccatca ccattaggga agagcagatg ggcaagcttg acctg                      705


<210>  24
<211>  235
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  24

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr 
    210                 215                 220                 


Ile Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 235 


<210>  25
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  25
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgcgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atatgaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aaagaaactt ca                         642


<210>  26
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  26

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Met Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Glu Thr Ser 
    210                 


<210>  27
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  27
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccaaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acaacaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aaagaaactt ca                         642


<210>  28
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  28

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Lys Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Asn Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Glu Thr Ser 
    210                 


<210>  29
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  29
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aaagaaactt ca                         642


<210>  30
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  30

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Glu Thr Ser 
    210                 


<210>  31
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  31
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta taaaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat aatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atatgaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aaagaaactt ca                         642


<210>  32
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  32

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Lys Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asn Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Met Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Glu Thr Ser 
    210                 


<210>  33
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  33
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc cgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atatgaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aaagaaactt ca                         642


<210>  34
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  34

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Met Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Glu Thr Ser 
    210                 


<210>  35
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  35
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta taaaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atatgaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aaggaaactt ca                         642


<210>  36
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  36

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Lys Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Met Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Glu Thr Ser 
    210                 


<210>  37
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  37
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atatgaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aaagaaactt ca                         642


<210>  38
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  38

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Met Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Glu Thr Ser 
    210                 


<210>  39
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  39
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat aatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acaacaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atatgaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aaagaaactt ca                         642


<210>  40
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  40

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asn Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Asn Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Met Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Glu Thr Ser 
    210                 


<210>  41
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  41
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tacaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acaacaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atatgaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aaagaaactt ca                         642


<210>  42
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  42

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Gln Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Asn Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Met Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Glu Thr Ser 
    210                 


<210>  43
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  43
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacgat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta taaaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat aatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgcgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acaacaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atatgaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aaagaaactt ca                         642


<210>  44
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  44

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Lys Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asn Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Asn Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Met Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Glu Thr Ser 
    210                 


<210>  45
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  45
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tacaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat aatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acaacaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atatgaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aaagaaactt ca                         642


<210>  46
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  46

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Gln Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asn Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Asn Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Met Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Glu Thr Ser 
    210                 


<210>  47
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  47
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat aatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atatgaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aaagaaactt ca                         642


<210>  48
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  48

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asn Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Met Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Glu Thr Ser 
    210                 


<210>  49
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  49
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat aatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acaacaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgtgggttat aaagaaactt ca                         642


<210>  50
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  50

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asn Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Asn Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Val 
        195                 200                 205             


Gly Tyr Lys Glu Thr Ser 
    210                 


<210>  51
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  51
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tacaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atatgaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aaagaaactt ca                         642


<210>  52
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  52

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Gln Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Met Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Glu Thr Ser 
    210                 


<210>  53
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  53
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacaggagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat aatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atatgaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aaagaaactt ca                         642


<210>  54
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  54

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asn Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Met Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Glu Thr Ser 
    210                 


<210>  55
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  55
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta taaaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat aatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acaacaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atatgaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aaagaaactt ca                         642


<210>  56
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  56

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Lys Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asn Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Asn Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Met Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Glu Thr Ser 
    210                 


<210>  57
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  57
atgcaggaaa taaccgtgga tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

cagattcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aaagaaactt ca                         642


<210>  58
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  58

Met Gln Glu Ile Thr Val Asp Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Ile His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Glu Thr Ser 
    210                 


<210>  59
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  59
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aagaaacttc ataaggccaa actggcgacc      660

atcaccatca ccattaggga agagcagatg ggcaaacttg actga                      705


<210>  60
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  60

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr 
    210                 215                 220                 


Ile Arg Glu Glu Gln Met Gly Lys Leu Asp 
225                 230                 


<210>  61
<211>  699
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  61
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aagaaacttc ataaggccaa actggcgacc      660

atcaccatca ccattaggga agagcagatg ggcaaactt                             699


<210>  62
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  62

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr 
    210                 215                 220                 


Ile Arg Glu Glu Gln Met Gly Lys Leu 
225                 230             


<210>  63
<211>  696
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  63
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aagaaacttc ataaggccaa actggcgacc      660

atcaccatca ccattaggga agagcagatg ggcaaa                                696


<210>  64
<211>  232
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  64

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr 
    210                 215                 220                 


Ile Arg Glu Glu Gln Met Gly Lys 
225                 230         


<210>  65
<211>  693
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  65
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aagaaacttc ataaggccaa actggcgacc      660

atcaccatca ccattaggga agagcagatg ggc                                   693


<210>  66
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  66

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr 
    210                 215                 220                 


Ile Arg Glu Glu Gln Met Gly 
225                 230     


<210>  67
<211>  690
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  67
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aagaaacttc ataaggccaa actggcgacc      660

atcaccatca ccattaggga agagcagatg                                       690


<210>  68
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  68

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr 
    210                 215                 220                 


Ile Arg Glu Glu Gln Met 
225                 230 


<210>  69
<211>  687
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  69
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aagaaacttc ataaggccaa actggcgacc      660

atcaccatca ccattaggga agagcag                                          687


<210>  70
<211>  229
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  70

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr 
    210                 215                 220                 


Ile Arg Glu Glu Gln 
225                 


<210>  71
<211>  684
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  71
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aagaaacttc ataaggccaa actggcgacc      660

atcaccatca ccattaggga agag                                             684


<210>  72
<211>  228
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  72

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr 
    210                 215                 220                 


Ile Arg Glu Glu 
225             


<210>  73
<211>  681
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  73
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aagaaacttc ataaggccaa actggcgacc      660

atcaccatca ccattaggga a                                                681


<210>  74
<211>  227
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  74

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr 
    210                 215                 220                 


Ile Arg Glu 
225         


<210>  75
<211>  678
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  75
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aagaaacttc ataaggccaa actggcgacc      660

atcaccatca ccattagg                                                    678


<210>  76
<211>  226
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  76

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr 
    210                 215                 220                 


Ile Arg 
225     


<210>  77
<211>  675
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  77
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aagaaacttc ataaggccaa actggcgacc      660

atcaccatca ccatt                                                       675


<210>  78
<211>  225
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  78

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr 
    210                 215                 220                 


Ile 
225 


<210>  79
<211>  672
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  79
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aagaaacttc ataaggccaa actggcgacc      660

atcaccatca cc                                                          672


<210>  80
<211>  224
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  80

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr 
    210                 215                 220                 


<210>  81
<211>  669
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  81
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aagaaacttc ataaggccaa actggcgacc      660

atcaccatc                                                              669


<210>  82
<211>  223
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  82

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile 
    210                 215                 220             


<210>  83
<211>  666
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  83
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aagaaacttc ataaggccaa actggcgacc      660

atcacc                                                                 666


<210>  84
<211>  222
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  84

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr 
    210                 215                 220         


<210>  85
<211>  663
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  85
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aagaaacttc ataaggccaa actggcgacc      660

atc                                                                    663


<210>  86
<211>  221
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  86

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile 
    210                 215                 220     


<210>  87
<211>  660
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  87
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aagaaacttc ataaggccaa actggcgacc      660


<210>  88
<211>  220
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  88

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr 
    210                 215                 220 


<210>  89
<211>  657
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  89
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aagaaacttc ataaggccaa actggcg         657


<210>  90
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  90

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Lys Leu His Lys Ala Lys Leu Ala 
    210                 215                 


<210>  91
<211>  654
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  91
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aagaaacttc ataaggccaa actg            654


<210>  92
<211>  218
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  92

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Lys Leu His Lys Ala Lys Leu 
    210                 215             


<210>  93
<211>  651
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  93
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aagaaacttc ataaggccaa a               651


<210>  94
<211>  217
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  94

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Lys Leu His Lys Ala Lys 
    210                 215         


<210>  95
<211>  648
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  95
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aagaaacttc ataaggcc                   648


<210>  96
<211>  216
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  96

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Lys Leu His Lys Ala 
    210                 215     


<210>  97
<211>  645
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  97
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aagaaacttc ataag                      645


<210>  98
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  98

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Lys Leu His Lys 
    210                 215 


<210>  99
<211>  642
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  99
atgcaggaaa taaccgtgag tgagttttcg aatatcagag agaatccggt aacaccatgg       60

aatcccgaac catcagcacc tgtgattgat cccacagcct atattgaccc ccaggcttca      120

gtcataggag aggtgacaat aggtgccaac gttatggttt cccccatggc atctattagg      180

agtgacgaag gaatgccaat tttcgtagga gacagaagca atgtccagga tggagttgtg      240

cttcatgccc ttgagacaat aaatgaagaa ggcgaaccta tagaagacaa cattgttgaa      300

gttgatggca aggaatacgc agtctatata ggaaataatg tttcgcttgc tcatcaatcc      360

caggttcatg gtccggcggc agtaggcgat gatacattta tcggtatgca ggctttcgtt      420

ttcaagtcaa aggtagggaa caactgtgta cttgagccga gatcggcagc aatcggtgta      480

accattcctg acggcaggta tatcccggca ggcatggttg tcacttcgca ggccgaagcc      540

gataagctgc cagaggtcac cgatgattac gcatacagcc atactaacga agccgtagta      600

tatgtaaacg tccaccttgc cgagggttat aagaaacttc at                         642


<210>  100
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  100

Met Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro 
1               5                   10                  15      


Val Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr 
            20                  25                  30          


Ala Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly 
        35                  40                  45              


Ala Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly 
    50                  55                  60                  


Met Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val 
65                  70                  75                  80  


Leu His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp 
                85                  90                  95      


Asn Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn 
            100                 105                 110         


Asn Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val 
        115                 120                 125             


Gly Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys 
    130                 135                 140                 


Val Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val 
145                 150                 155                 160 


Thr Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser 
                165                 170                 175     


Gln Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr 
            180                 185                 190         


Ser His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu 
        195                 200                 205             


Gly Tyr Lys Lys Leu His 
    210                 


<210>  101
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal fusion sequence

<400>  101

Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile Arg Glu Glu Gln Met 
1               5                   10                  15      


Gly Lys Leu Asp Leu 
            20      


<210>  102
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal fusion sequence

<400>  102

Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile Arg Glu Glu Gln Met 
1               5                   10                  15      


Gly Lys Leu Asp 
            20  


<210>  103
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal fusion sequence

<400>  103

Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile Arg Glu Glu Gln Met 
1               5                   10                  15      


Gly Lys Leu 
            


<210>  104
<211>  18
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal fusion sequence

<400>  104

Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile Arg Glu Glu Gln Met 
1               5                   10                  15      


Gly Lys 
        


<210>  105
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal fusion sequence

<400>  105

Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile Arg Glu Glu Gln Met 
1               5                   10                  15      


Gly 
    


<210>  106
<211>  16
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal fusion sequence

<400>  106

Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile Arg Glu Glu Gln Met 
1               5                   10                  15      


<210>  107
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal fusion sequence

<400>  107

Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile Arg Glu Glu Gln 
1               5                   10                  15  


<210>  108
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal fusion sequence

<400>  108

Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile Arg Glu Glu 
1               5                   10                  


<210>  109
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal fusion sequence

<400>  109

Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile Arg Glu 
1               5                   10              


<210>  110
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal fusion sequence

<400>  110

Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile Arg 
1               5                   10          


<210>  111
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal fusion sequence

<400>  111

Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
1               5                   10      


<210>  112
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal fusion sequence

<400>  112

Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr 
1               5                   10  


<210>  113
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal fusion sequence

<400>  113

Lys Ala Lys Leu Ala Thr Ile Thr Ile 
1               5                   


<210>  114
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal fusion sequence

<400>  114

Lys Ala Lys Leu Ala Thr Ile Thr 
1               5               


<210>  115
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal fusion sequence

<400>  115

Lys Ala Lys Leu Ala Thr Ile 
1               5           


<210>  116
<211>  6
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal fusion sequence

<400>  116

Lys Ala Lys Leu Ala Thr 
1               5       


<210>  117
<211>  5
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal fusion sequence

<400>  117

Lys Ala Lys Leu Ala 
1               5   


<210>  118
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  C-terminal fusion sequence

<400>  118

Lys Ala Lys Leu 
1               


<210>  119
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  119
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  120
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  120

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  121
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  121
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattaccct tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  122
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  122

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Pro Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  123
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  123
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg taggggctaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  124
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  124

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Ala Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  125
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  125
caggaaataa ccgtgagtga gttttcgaat atcagagaga atgttgtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  126
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  126

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Val Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  127
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  127
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggtttc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  128
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  128

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Val Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  129
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  129
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagcggta ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  130
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  130

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


Gly Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  131
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  131
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcgcgtgt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  132
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  132

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Arg Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  133
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  133
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat catctcctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  134
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  134

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ser Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  135
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  135
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagt ggtacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  136
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  136

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Trp Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  137
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  137
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttatga aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  138
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  138

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu Met Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  139
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  139
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgctgatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  140
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  140

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Leu Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  141
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  141
cagtggataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  142
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  142

Gln Trp Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  143
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  143
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acaggttata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  144
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  144

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Gly 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  145
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  145
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagcgaga ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  146
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  146

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


Glu Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  147
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  147
caggctataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgggtatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  148
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  148

Gln Ala Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Gly Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  149
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  149
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggcataa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  150
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  150

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly His Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  151
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  151
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacttgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  152
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  152

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Leu Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  153
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  153
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag cgtcttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  154
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  154

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Arg Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  155
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  155
aatgaaataa ccgtgagtga gttttcgcct atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  156
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  156

Asn Glu Ile Thr Val Ser Glu Phe Ser Pro Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  157
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  157
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctctgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  158
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  158

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Ser Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  159
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  159
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaaat      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  160
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  160

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Asn 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  161
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  161
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagctg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cgacagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  162
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  162

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Ala Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Thr Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  163
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  163
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggacagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  164
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  164

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Gln Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  165
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  165
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcagaggt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  166
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  166

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Glu Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  167
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  167
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttgaga aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  168
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  168

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu Glu Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  169
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  169
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgctcccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  170
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  170

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Ala Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  171
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  171
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaactttgga aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  172
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  172

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu Trp Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  173
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  173
caggctataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  174
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  174

Gln Ala Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  175
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  175
caggaaataa ccatgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  176
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  176

Gln Glu Ile Thr Met Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  177
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  177
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaactttgta aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  178
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  178

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu Cys Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  179
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  179
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

aaggaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  180
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  180

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Lys Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  181
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  181
cctgaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgagtatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  182
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  182

Pro Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Ser Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  183
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  183
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatgat acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  184
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  184

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Asp Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  185
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  185
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggccagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  186
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  186

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Gln Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  187
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  187
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaaga cttacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  188
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  188

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Thr Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  189
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  189
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcagtc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  190
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  190

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ser Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  191
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  191
cagcttataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  192
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  192

Gln Leu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  193
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  193
caggaaataa ccgtgagtga gttttcgaat atcagattta atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  194
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  194

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Phe Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  195
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  195
caggaaataa cccagagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  196
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  196

Gln Glu Ile Thr Gln Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  197
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  197
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttcatcccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  198
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  198

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile His Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  199
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  199
caggaaataa ccgtgcctga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  200
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  200

Gln Glu Ile Thr Val Pro Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  201
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  201
gctgaaataa ccgtgagtga gtttgttaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tggtgatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  202
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  202

Ala Glu Ile Thr Val Ser Glu Phe Val Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Val Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  203
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  203
caggaaataa ccgtgagtgc tttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  204
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  204

Gln Glu Ile Thr Val Ser Ala Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  205
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  205
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttgtgtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  206
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  206

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Cys Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  207
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  207
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgggggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  208
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  208

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gly Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  209
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  209
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgaca agaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  210
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  210

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Lys Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  211
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  211
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tggatatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  212
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  212

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Asp Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  213
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  213
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttgata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  214
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  214

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu Asp Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  215
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  215
catgaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  216
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  216

His Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  217
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  217
caggaaataa ccgtgagtga gttttggaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccatca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  218
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  218

Gln Glu Ile Thr Val Ser Glu Phe Trp Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp His Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  219
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  219
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggaagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttaaga aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  220
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  220

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Glu Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu Lys Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  221
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  221
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccggtccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  222
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  222

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Gly Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  223
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  223
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagcgcta ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  224
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  224

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


Ala Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  225
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  225
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

ccctctccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  226
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  226

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Ser Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  227
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  227
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatcag acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  228
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  228

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Gln Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  229
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  229
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaatcgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  230
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  230

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Ile Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  231
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  231
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggacctg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  232
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  232

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Pro Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  233
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  233
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgattgt acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  234
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  234

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Cys Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  235
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  235
caggaaataa ccgtgagtca gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  236
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  236

Gln Glu Ile Thr Val Ser Gln Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  237
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  237
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcgtgggt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  238
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  238

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Trp Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  239
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  239
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

cagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  240
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  240

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Gln Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  241
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  241
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

attgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  242
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  242

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Ile Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  243
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  243
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacgt tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  244
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  244

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Val Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  245
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  245
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacaa ggttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  246
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  246

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Lys Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  247
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  247
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtcagcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  248
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  248

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Gln Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  249
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  249
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tatggttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  250
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  250

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Met Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  251
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  251
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tgttgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  252
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  252

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Val Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  253
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  253
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacactc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  254
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  254

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Thr His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  255
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  255
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaaccagc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  256
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  256

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Gln His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  257
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  257
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttcctgaaga gcagatgggc aagcttgacc tg                         702


<210>  258
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  258

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Pro Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  259
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  259
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

ggtatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  260
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  260

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Gly Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  261
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  261
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttgatgaaga gcagatgggc aagcttgacc tg                         702


<210>  262
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  262

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Asp Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  263
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  263
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgaca ct                         702


<210>  264
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  264

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Thr 
225                 230                 


<210>  265
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  265
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacg tt                         702


<210>  266
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  266

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Val 
225                 230                 


<210>  267
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  267
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgact ct                         702


<210>  268
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  268

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Ser 
225                 230                 


<210>  269
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  269
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca tgagggaaga gcagatgggc aagcttgacc tg                         702


<210>  270
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  270

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Met 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  271
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  271
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcaggctggc aagcttgacc tg                         702


<210>  272
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  272

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Ala Gly Lys Leu Asp Leu 
225                 230                 


<210>  273
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  273
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata agtctaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  274
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  274

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ser Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  275
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  275
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccggtatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  276
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  276

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Gly Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  277
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  277
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcatg ctgccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  278
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  278

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Ala Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  279
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  279
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

gagatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  280
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  280

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Glu Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  281
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  281
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcaccc tgagggaaga gcagatgggc aagcttgacc tg                         702


<210>  282
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  282

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Leu 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  283
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  283
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaatatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  284
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  284

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Asn Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  285
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  285
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttggtgaaga gcagatgggc aagcttgacc tg                         702


<210>  286
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  286

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Gly Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  287
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  287
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatggat aagcttgacc tg                         702


<210>  288
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  288

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Asp Lys Leu Asp Leu 
225                 230                 


<210>  289
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  289
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcaggacc tg                         702


<210>  290
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  290

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Gln Asp Leu 
225                 230                 


<210>  291
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  291
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccggtct ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  292
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  292

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Gly Leu Ala Thr Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  293
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  293
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacct gtagggaaga gcagatgggc aagcttgacc tg                         702


<210>  294
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  294

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Cys 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  295
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  295
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccggt      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  296
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  296

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Gly Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  297
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  297
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accactacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  298
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  298

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Thr Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  299
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  299
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccgatatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  300
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  300

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Asp Ile Thr Ile Thr Ile 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  301
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  301
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcaccg gtagggaaga gcagatgggc aagcttgacc tg                         702


<210>  302
<211>  234
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  302

Gln Glu Ile Thr Val Ser Glu Phe Ser Asn Ile Arg Glu Asn Pro Val 
1               5                   10                  15      


Thr Pro Trp Asn Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala 
            20                  25                  30          


Tyr Ile Asp Pro Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala 
        35                  40                  45              


Asn Val Met Val Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met 
    50                  55                  60                  


Pro Ile Phe Val Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu 
65                  70                  75                  80  


His Ala Leu Glu Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn 
                85                  90                  95      


Ile Val Glu Val Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn 
            100                 105                 110         


Val Ser Leu Ala His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly 
        115                 120                 125             


Asp Asp Thr Phe Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val 
    130                 135                 140                 


Gly Asn Asn Cys Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr 
145                 150                 155                 160 


Ile Pro Asp Gly Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln 
                165                 170                 175     


Ala Glu Ala Asp Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser 
            180                 185                 190         


His Thr Asn Glu Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly 
        195                 200                 205             


Tyr Lys Lys Leu His Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Gly 
    210                 215                 220                 


Arg Glu Glu Gln Met Gly Lys Leu Asp Leu 
225                 230                 


<210>  303
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  303
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaggccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  304
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  304
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggttagtc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  305
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  305
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaggtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  306
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  306
caggaaataa ccgtgagtga gttttcgaat atcagagaga atcctgtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  307
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  307
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ctatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  308
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  308
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatataggt aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  309
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  309
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agatctaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  310
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  310
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactg gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  311
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  311
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgtcc acctggccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  312
<211>  702
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Variant of M. thermophila carbonic anhydrase

<400>  312
caggaaataa ccgtgagtga gttttcgaat atcagagaga atccggtaac accatggaat       60

cccgaaccat cagcacctgt gattgatccc acagcctata ttgaccccca ggcttcagtc      120

ataggagagg tgacaatagg tgccaacgtt atggtttccc ccatggcatc tattaggagt      180

gacgaaggaa tgccaatttt cgtaggagac agaagcaatg tccaggatgg agttgtgctt      240

catgcccttg agacaataaa tgaagaaggc gaacctatag aagacaacat tgttgaagtt      300

gatggcaagg aatacgcagt ctatatagga aataatgttt cgcttgctca tcaatcccag      360

gttcatggtc cggcggcagt aggcgatgat acatttatcg gtatgcaggc tttcgttttc      420

aagtcaaagg tagggaacaa ctgtgtactt gagccgagat cggcagcaat cggtgtaacc      480

attcctgacg gcaggtatat cccggcaggc atggttgtca cttcgcaggc cgaagccgat      540

aagctgccag aggtcaccga tgattacgca tacagccata ctaacgaagc cgtagtatat      600

gtaaacgttc accttgccga gggttataag aaacttcata aggccaaact ggccaccatc      660

accatcacca ttagggaaga gcagatgggc aagcttgacc tg                         702


<210>  313
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  nprm signal peptide

<400>  313

Met Lys Lys Lys Lys Gln Ala Leu Lys Val Leu Leu Ser Val Gly Ile 
1               5                   10                  15      


Leu Ser Ser Ser Phe Ala Phe Ala His Thr Ser Ser Ala 
            20                  25                  


<210>  314
<211>  25
<212>  PRT
<213>  Artificial sequence

<220>
<223>  YngK signal peptide

<400>  314

Met Tyr Ile Lys Lys Cys Ile Gly Ser Ile Leu Phe Leu Leu Leu Phe 
1               5                   10                  15      


Cys Ser Ser Ala Leu Pro Ala Lys Ala 
            20                  25  


<210>  315
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  PenG signal peptide

<400>  315

Met Lys Thr Lys Trp Leu Ile Ser Val Ile Ile Leu Phe Val Phe Ile 
1               5                   10                  15      


Phe Pro Gln Asn Leu Val Phe Ala 
            20                  


<210>  316
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C-terminal fusion sequence

<400>  316

Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile Pro Glu Glu Gln Met 
1               5                   10                  15      


Gly Lys Leu Asp Leu 
            20      


<210>  317
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C-terminal fusion sequence

<400>  317

Lys Ala Lys Leu Ala Thr Ile Gly Ile Thr Ile Arg Glu Glu Gln Met 
1               5                   10                  15      


Gly Lys Leu Asp Leu 
            20      


<210>  318
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C-terminal fusion sequence

<400>  318

Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile Asp Glu Glu Gln Met 
1               5                   10                  15      


Gly Lys Leu Asp Leu 
            20      


<210>  319
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C-terminal fusion sequence

<400>  319

Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile Arg Glu Glu Gln Met 
1               5                   10                  15      


Gly Lys Leu Asp Thr 
            20      


<210>  320
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C-terminal fusion sequence

<400>  320

Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile Arg Glu Glu Gln Met 
1               5                   10                  15      


Gly Lys Leu Asp Val 
            20      


<210>  321
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C-terminal fusion sequence

<400>  321

Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile Arg Glu Glu Gln Met 
1               5                   10                  15      


Gly Lys Leu Asp Ser 
            20      


<210>  322
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C-terminal fusion sequence

<400>  322

Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Met Arg Glu Glu Gln Met 
1               5                   10                  15      


Gly Lys Leu Asp Leu 
            20      


<210>  323
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C-terminal fusion sequence

<400>  323

Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile Arg Glu Glu Gln Ala 
1               5                   10                  15      


Gly Lys Leu Asp Leu 
            20      


<210>  324
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C-terminal fusion sequence

<400>  324

Lys Ser Lys Leu Ala Thr Ile Thr Ile Thr Ile Arg Glu Glu Gln Met 
1               5                   10                  15      


Gly Lys Leu Asp Leu 
            20      


<210>  325
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C-terminal fusion sequence

<400>  325

Lys Ala Lys Leu Ala Gly Ile Thr Ile Thr Ile Arg Glu Glu Gln Met 
1               5                   10                  15      


Gly Lys Leu Asp Leu 
            20      


<210>  326
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C-terminal fusion sequence

<400>  326

Ala Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile Arg Glu Glu Gln Met 
1               5                   10                  15      


Gly Lys Leu Asp Leu 
            20      


<210>  327
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C-terminal fusion sequence

<400>  327

Lys Ala Lys Leu Ala Thr Ile Glu Ile Thr Ile Arg Glu Glu Gln Met 
1               5                   10                  15      


Gly Lys Leu Asp Leu 
            20      


<210>  328
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C-terminal fusion sequence

<400>  328

Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Leu Arg Glu Glu Gln Met 
1               5                   10                  15      


Gly Lys Leu Asp Leu 
            20      


<210>  329
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C-terminal fusion sequence

<400>  329

Lys Ala Lys Leu Ala Asn Ile Thr Ile Thr Ile Arg Glu Glu Gln Met 
1               5                   10                  15      


Gly Lys Leu Asp Leu 
            20      


<210>  330
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C-terminal fusion sequence

<400>  330

Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile Gly Glu Glu Gln Met 
1               5                   10                  15      


Gly Lys Leu Asp Leu 
            20      


<210>  331
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C-terminal fusion sequence

<400>  331

Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile Arg Glu Glu Gln Met 
1               5                   10                  15      


Asp Lys Leu Asp Leu 
            20      


<210>  332
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C-terminal fusion sequence

<400>  332

Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Ile Arg Glu Glu Gln Met 
1               5                   10                  15      


Gly Lys Gln Asp Leu 
            20      


<210>  333
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C-terminal fusion sequence

<400>  333

Lys Ala Gly Leu Ala Thr Ile Thr Ile Thr Ile Arg Glu Glu Gln Met 
1               5                   10                  15      


Gly Lys Leu Asp Leu 
            20      


<210>  334
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C-terminal fusion sequence

<400>  334

Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Cys Arg Glu Glu Gln Met 
1               5                   10                  15      


Gly Lys Leu Asp Leu 
            20      


<210>  335
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C-terminal fusion sequence

<400>  335

Lys Ala Lys Leu Ala Thr Gly Thr Ile Thr Ile Arg Glu Glu Gln Met 
1               5                   10                  15      


Gly Lys Leu Asp Leu 
            20      


<210>  336
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C-terminal fusion sequence

<400>  336

Lys Ala Lys Leu Ala Thr Ile Thr Thr Thr Ile Arg Glu Glu Gln Met 
1               5                   10                  15      


Gly Lys Leu Asp Leu 
            20      


<210>  337
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C-terminal fusion sequence

<400>  337

Lys Ala Lys Leu Ala Asp Ile Thr Ile Thr Ile Arg Glu Glu Gln Met 
1               5                   10                  15      


Gly Lys Leu Asp Leu 
            20      


<210>  338
<211>  21
<212>  PRT
<213>  Artificial sequence

<220>
<223>  C-terminal fusion sequence

<400>  338

Lys Ala Lys Leu Ala Thr Ile Thr Ile Thr Gly Arg Glu Glu Gln Met 
1               5                   10                  15      


Gly Lys Leu Asp Leu 
            20      


<210>  339
<211>  678
<212>  DNA
<213>  Artificial sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  339
ggatgtattt cagaaggagc cgaagataac gtagcacaag aaattacagt agatgagttc       60

tcaaacattc gcgaaaaccc tgtaacaccg tggaatcctg aaccttctgc tcctgttatt      120

gatccaacgg catacattga tcctcaggca agcgttatcg gagaggtaac aattggcgct      180

aatgtaatgg tatctcctat ggcttcaatt agatcagatg aaggaatgcc tatctttgta      240

ggagatagat ctaacgttca agatggagta gtactacatg ctcttgaaac aattaatgaa      300

gaaggagaac ctattgaaga caacattgtt gaagttgatg gaaaagagta cgctgtatat      360

atcgggaaca atgtatcttt agctcatcaa tctcaagtac atggacctgc tgctgtaggc      420

gacgacacat tcattggtat gcaggcattt gtatttaaat ctaaagtagg aaacaactgt      480

gttcttgagc ctagatctgc tgctattgga gtaacaatcc ctgatggtag atatattcct      540

gctggcatgg tagtaacatc tcaagctgaa gcggacaaat tacctgaggt aacagatgac      600

tatgcttatt ctcatacaaa cgaagctgta gtatatgtga acgtacatct tgctgaagga      660

tacaaggaaa ccagctaa                                                    678


<210>  340
<211>  225
<212>  PRT
<213>  Artificial sequence

<220>
<223>  variant of M. thermophila carbonic anhydrase

<400>  340

Gly Cys Ile Ser Glu Gly Ala Glu Asp Asn Val Ala Gln Glu Ile Thr 
1               5                   10                  15      


Val Asp Glu Phe Ser Asn Ile Arg Glu Asn Pro Val Thr Pro Trp Asn 
            20                  25                  30          


Pro Glu Pro Ser Ala Pro Val Ile Asp Pro Thr Ala Tyr Ile Asp Pro 
        35                  40                  45              


Gln Ala Ser Val Ile Gly Glu Val Thr Ile Gly Ala Asn Val Met Val 
    50                  55                  60                  


Ser Pro Met Ala Ser Ile Arg Ser Asp Glu Gly Met Pro Ile Phe Val 
65                  70                  75                  80  


Gly Asp Arg Ser Asn Val Gln Asp Gly Val Val Leu His Ala Leu Glu 
                85                  90                  95      


Thr Ile Asn Glu Glu Gly Glu Pro Ile Glu Asp Asn Ile Val Glu Val 
            100                 105                 110         


Asp Gly Lys Glu Tyr Ala Val Tyr Ile Gly Asn Asn Val Ser Leu Ala 
        115                 120                 125             


His Gln Ser Gln Val His Gly Pro Ala Ala Val Gly Asp Asp Thr Phe 
    130                 135                 140                 


Ile Gly Met Gln Ala Phe Val Phe Lys Ser Lys Val Gly Asn Asn Cys 
145                 150                 155                 160 


Val Leu Glu Pro Arg Ser Ala Ala Ile Gly Val Thr Ile Pro Asp Gly 
                165                 170                 175     


Arg Tyr Ile Pro Ala Gly Met Val Val Thr Ser Gln Ala Glu Ala Asp 
            180                 185                 190         


Lys Leu Pro Glu Val Thr Asp Asp Tyr Ala Tyr Ser His Thr Asn Glu 
        195                 200                 205             


Ala Val Val Tyr Val Asn Val His Leu Ala Glu Gly Tyr Lys Glu Thr 
    210                 215                 220                 


Ser 
225 


<210>  341
<211>  33
<212>  DNA
<213>  Artificial sequence

<220>
<223>  5'-extension encoding 11 amino acid N-terminal extension

<400>  341
ggatgtattt cagaaggagc cgaagataac gta                                    33


<210>  342
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  N-terminal fusion sequence

<400>  342

Gly Cys Ile Ser Glu Gly Ala Glu Asp Asn Val 
1               5                   10      


<210>  343
<211>  72
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Signal peptide

<400>  343
atgaaaaaga taatttcttc attagcttta tgcagctcat taattgtgtt accaacaata       60

agccaggcag ct                                                           72


<210>  344
<211>  24
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Signal peptide

<400>  344

Met Lys Lys Ile Ile Ser Ser Leu Ala Leu Cys Ser Ser Leu Ile Val 
1               5                   10                  15      


Leu Pro Thr Ile Ser Gln Ala Ala 
            20                  


<210>  345
<211>  87
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Signal peptide

<400>  345
atgaaaaaga aactattcgg ttatatcatg gcaagcggtt taacgctagg agttatggca       60

gctgcaaatt ccacggcatt tgcagca                                           87


<210>  346
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Signal peptide

<400>  346

Met Lys Lys Lys Leu Phe Gly Tyr Ile Met Ala Ser Gly Leu Thr Leu 
1               5                   10                  15      


Gly Val Met Ala Ala Ala Asn Ser Thr Ala Phe Ala Ala 
            20                  25                  


<210>  347
<211>  81
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Signal peptide

<400>  347
atgaaaaaga aaatgctttt acttaacaca acggttttat taggcctggg aggaatttta       60

tcaactccag cgtatgcctc t                                                 81


<210>  348
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Signal peptide

<400>  348

Met Lys Lys Lys Met Leu Leu Leu Asn Thr Thr Val Leu Leu Gly Leu 
1               5                   10                  15      


Gly Gly Ile Leu Ser Thr Pro Ala Tyr Ala Ser 
            20                  25          


<210>  349
<211>  102
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Signal peptide

<400>  349
atgaaaaaga atacacgcag taaaacaaag aaaatcctat ccacatcact ggcactttct       60

ctattatcaa tgcctctttt aactacacag gcaggagcgg aa                         102


<210>  350
<211>  34
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Signal peptide

<400>  350

Met Lys Lys Asn Thr Arg Ser Lys Thr Lys Lys Ile Leu Ser Thr Ser 
1               5                   10                  15      


Leu Ala Leu Ser Leu Leu Ser Met Pro Leu Leu Thr Thr Gln Ala Gly 
            20                  25                  30          


Ala Glu 
        


<210>  351
<211>  99
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Signal peptide

<400>  351
atgctaaaga aagcgaatcg tacagttatg aatatggggt tagcagcatt acttgttcct       60

gctgccctaa catttagcac aacttcagca agtgcaaat                              99


<210>  352
<211>  29
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Signal peptide

<400>  352

Met Lys Lys Val Ser Ile Arg Ser Val Leu Ser Thr Val Ala Phe Ser 
1               5                   10                  15      


Val Ala Leu Ser Ser Phe Ala Met Gly Ala Ser Ala Asn 
            20                  25                  


<210>  353
<211>  90
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Signal peptide

<400>  353
atgaaaatga aacgagttgc taagcataca actgctgcta cattggctgc agccttatta       60

gtaggcgggg gatatcaaac atttgctaaa                                        90


<210>  354
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Signal peptide

<400>  354

Met Lys Met Lys Arg Val Ala Lys His Thr Thr Ala Ala Thr Leu Ala 
1               5                   10                  15      


Ala Ala Leu Leu Val Gly Gly Gly Tyr Gln Thr Phe Ala Lys 
            20                  25                  30  


<210>  355
<211>  99
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Signal peptide

<400>  355
atgctaaaga aagcgaatcg tacagttatg aatatggggt tagcagcatt acttgttcct       60

gctgccctaa catttagcac aacttcagca agtgcaaat                              99


<210>  356
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Signal peptide

<400>  356

Met Leu Lys Lys Ala Asn Arg Thr Val Met Asn Met Gly Leu Ala Ala 
1               5                   10                  15      


Leu Leu Val Pro Ala Ala Leu Thr Phe Ser Thr Thr Ser Ala Ser Ala 
            20                  25                  30          


Asn 
    


<210>  357
<211>  78
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Signal peptide

<400>  357
atgatgaaat taagtaaaaa attaatgatc cctgtactag gagcttcact attgatgccg       60

actattgcaa atgcggag                                                     78


<210>  358
<211>  26
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Signal peptide

<400>  358

Met Met Lys Leu Ser Lys Lys Leu Met Ile Pro Val Leu Gly Ala Ser 
1               5                   10                  15      


Leu Leu Met Pro Thr Ile Ala Asn Ala Glu 
            20                  25      


<210>  359
<211>  90
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Signal peptide

<400>  359
atgaatatta agaaaatcgc aaagcaaact acagctttat ctttcgctac agctctgtta       60

gtaggtgctg gatctcaaac atgggctgct                                        90


<210>  360
<211>  30
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Signal peptide

<400>  360

Met Asn Ile Lys Lys Ile Ala Lys Gln Thr Thr Ala Leu Ser Phe Ala 
1               5                   10                  15      


Thr Ala Leu Leu Val Gly Ala Gly Ser Gln Thr Trp Ala Ala 
            20                  25                  30  


<210>  361
<211>  81
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Signal peptide

<400>  361
atgaataaaa aaggtataat atccctagtt tctgctggtc tgttagcatc aacactatcc       60

gttcagtctg ttcaagcaga t                                                 81


<210>  362
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Signal peptide

<400>  362

Met Asn Lys Lys Gly Ile Ile Ser Leu Val Ser Ala Gly Leu Leu Ala 
1               5                   10                  15      


Ser Thr Leu Ser Val Gln Ser Val Gln Ala Asp 
            20                  25          


