SEQUENCE LISTINGS

<110>    GREEN CROSS Corporation

<120>    Antibodies specifically binding to the epidermal growth factor
         receptor

<130>    PCA908052GCC

<150>    KR10-2009-0092401
<151>    2009-09-29

<160>    44

<170>    KopatentIn 1.71

<210>    1
<211>    5
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    CDR 1 of heavy chain variable region of human antibody


<400>    1
Asp Tyr Asp Met Ser
  1               5


<210>    2
<211>    17
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    CDR 2 of heavy chain variable region of human antibody


<400>    2
Gly Ile Leu Gly Gly Ser Glu Arg Ser Tyr Tyr Arg Asp Ser Val Lys
  1               5                  10                  15 

Gly
   


<210>    3
<211>    10
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    CDR 3 of heavy chain variable region of human antibody


<400>    3
His Gly Ser Pro Gly Tyr Thr Leu Tyr Ala
  1               5                  10


<210>    4
<211>    16
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    CDR 1 of light chain variable region of human antibody


<400>    4
Arg Ser Asn Gln Asp Leu Thr His Ser Asn Gly Asn Thr Tyr Leu Glu
  1               5                  10                  15 




<210>    5
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    CDR 2 of light chain variable region of human antibody


<400>    5
Lys Val Ser Asn Arg Phe Ser
  1               5        


<210>    6
<211>    9
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    CDR 3 of light chain variable region of human antibody


<400>    6
Met Gln Gly Thr His Trp Pro Trp Thr
  1               5                


<210>    7
<211>    122
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain variable region of human antibody


<400>    7
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Gly
  1               5                  10                  15 

Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
             20                  25                  30 

Asp Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
         35                  40                  45 

Ser Gly Ile Leu Gly Gly Ser Glu Arg Ser Tyr Tyr Arg Asp Ser Val
     50                  55                  60 

Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Arg Lys Thr Leu Tyr
 65                  70                  75                  80 

Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                 85                  90                  95 

Ala Arg His Gly Ser Pro Gly Tyr Thr Leu Tyr Ala Trp Asp Tyr Trp
            100                 105                 110 

Gly Gln Gly Thr Thr Val Thr Val Ser Ser
        115                 120        


<210>    8
<211>    113
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain variable region of human antibody


<400>    8
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly
  1               5                  10                  15 

Glu Pro Ala Ser Ile Ser Cys Arg Ser Asn Gln Asp Leu Thr His Ser
             20                  25                  30 

Asn Gly Asn Thr Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
         35                  40                  45 

Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
     50                  55                  60 

Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Arg Ile
 65                  70                  75                  80 

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly
                 85                  90                  95 

Thr His Trp Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
            100                 105                 110 

Arg
   


<210>    9
<211>    16
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    CDR 1 of light chain variable region of human antibody


<400>    9
Arg Ser Ser Gln Ser Val Asp Met Gly Ile Gly Asn Asn Tyr Leu Glu
  1               5                  10                  15 




<210>    10
<211>    113
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain variable region of human antibody


<400>    10
Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Thr Pro Gly
  1               5                  10                  15 

Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Val Asp Met Gly
             20                  25                  30 

Ile Gly Asn Asn Tyr Leu Glu Trp Tyr Leu Gln Lys Pro Gly Gln Ser
         35                  40                  45 

Pro Arg Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro
     50                  55                  60 

Asp Arg Phe Ser Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Arg Ile
 65                  70                  75                  80 

Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Met Gln Gly
                 85                  90                  95 

Thr His Trp Pro Trp Thr Phe Gly Gln Gly Thr Lys Val Asp Ile Lys
            100                 105                 110 

Arg
   


<210>    11
<211>    15
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    CDR 1 of heavy chain variable region of human antibody


<400>    11
gactacgaca tgagc                                                          15


<210>    12
<211>    51
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    CDR 2 of heavy chain variable region of human antibody


<400>    12
gggatccttg gtggtagtga gcgttcgtac tatagggact ccgtgaaggg c                  51


<210>    13
<211>    39
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    CDR 3 of heavy chain variable region of human antibody


<400>    13
cacggcagcc cgggatacac gttgtatgcg tgggactac                                39


<210>    14
<211>    366
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Heavy chain variable region of human antibody


<400>    14
gaggtgcagc tggtggagtc tgggggaggc gtggtacagc ctggagggtc cctgagactc         60

tcctgtgcag cctctggatt caccttcagt gactacgaca tgagctggat ccgccaggct        120

ccagggaagg ggctggagtg ggtctcaggg atccttggtg gtagtgagcg ttcgtactat        180

agggactccg tgaagggccg gttcaccatc tccagagaca attccaggaa aaccctgtat        240

ctgcaaatga acagcctgag agccgaggac acggctgtgt attactgtgc gagacacggc        300

agcccgggat acacgttgta tgcgtgggac tactggggcc aagggaccac ggtcaccgtc        360

tcctca                                                                   366


<210>    15
<211>    48
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    CDR 1 of light chain variable region of human antibody


<400>    15
aggtctaatc aggacttgac ccatagtaac ggaaacacct atttggag                      48


<210>    16
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    CDR 2 of light chain variable region of human antibody


<400>    16
aaggtttcta accggttctc t                                                   21


<210>    17
<211>    27
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    CDR 3 of light chain variable region of human antibody


<400>    17
atgcaaggta cacactggcc gtggacg                                             27


<210>    18
<211>    339
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Light chain variable region of human antibody


<400>    18
gatattgtga tgacccagac tccactctcc ctgcccgtca cccctggaga gccggcctcc         60

atctcatgca ggtctaatca ggacttgacc catagtaacg gaaacaccta tttggagtgg        120

tacctgcaga agccagggca gtctccaaga ctcctaattt ataaggtttc taaccggttc        180

tctgtctcca aagacaaccg gtgtggcagt ggggcaggta caaccgtcac actgagaatc        240

agcagggtgg aagctgagga tgttggggtt tattactgca tgcaaggtac acactggccg        300

tggacgttcg gccaagggac caaggtggat atcaaacgt                               339


<210>    19
<211>    48
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    CDR 1 of light chain variable region of human antibody


<400>    19
aggtctagtc agagcgtcga catggggatc ggaaacaact atttggag                      48


<210>    20
<211>    339
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Light chain variable region of human antibody


<400>    20
gatattgtga tgacccagac tccactctcc ctgcccgtca cccctggaga gccggcctcc         60

atctcatgca ggtctagtca gagcgtcgac atggggatcg gaaacaacta tttggagtgg        120

tacctgcaga agccagggca gtctccaaga ctcctaattt ataaggtttc taaccggttc        180

tctggggtcc cagacagatt cagtggcagt ggggcaggta cagatttcac actgagaatc        240

agcagggtgg aagctgagga tgttggggtt tattactgca tgcaaggtac acactggccg        300

tggacgttcg gccaagggac caaggtggat atcaaacgt                               339


<210>    21
<211>    36
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    scFv-forward primer


<400>    21
gttgttcctt tctatgcggc ccagccggcc atggcc                                   36


<210>    22
<211>    30
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    scFv-reverse primer


<400>    22
gagtcattct cgacttgcgg ccgcacgttt                                          30


<210>    23
<211>    27
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    scFv-reverse primer


<400>    23
gagtcattct cgacttgcgg ccgcacc                                             27


<210>    24
<211>    39
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VH1-forward primer


<400>    24
cagccggcca tggcccaggt gcagctggtg cagtctggg                                39


<210>    25
<211>    39
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VH3-forward primer


<400>    25
cagccggcca tggccsaggt gcagctggtg gagtctggg                                39


<210>    26
<211>    39
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VH4-forward primer


<400>    26
cagccggcca tggcccaggt gcagctgcag gagtcgggc                                39


<210>    27
<211>    45
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VH-reverse primer


<400>    27
cgatccgcca cctccggagc cacctccgcc tgaaccgcct ccacc                         45


<210>    28
<211>    48
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VK1/3A-forward primer


<400>    28
ggtggctccg gaggtggcgg atcggacatc cagatgaccc agtctcca                      48


<210>    29
<211>    48
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VK1/3B-forward primer


<400>    29
ggtggctccg gaggtggcgg atcggaaatt gtgttgacgc agtctcca                      48


<210>    30
<211>    51
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VK2-forward primer


<400>    30
ggtggctccg gaggtggcgg atcggatatt gtgatgaccc agactccact c                  51


<210>    31
<211>    39
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    JK_A-reverse primer


<400>    31
tcgacttgcg gccgcacgtt tgatwtccac yttggtccc                                39


<210>    32
<211>    39
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    JK_B-reverse primer


<400>    32
tcgacttgcg gccgcacgtt tgatctccas cttggtccc                                39


<210>    33
<211>    39
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    JK_C-reverse primer


<400>    33
tcgacttgcg gccgcacgtt taatctccag tcgtgtccc                                39


<210>    34
<211>    48
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VL_A-forward primer


<400>    34
ggtggctccg gaggtggcgg atcgcagtct gysctgactc agccaccc                      48


<210>    35
<211>    48
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VL_B-forward primer


<400>    35
ggtggctccg gaggtggcgg atcgtcctat gagctgacwc agccaccc                      48


<210>    36
<211>    42
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    JL_A-reverse primer


<400>    36
ttctcgactt gcggccgcac ctaggacggt sascttggtc cc                            42


<210>    37
<211>    42
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    JL_B-reverse primer


<400>    37
ttctcgactt gcggccgcac cgaggacggt cagctgggtg cc                            42


<210>    38
<211>    24
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    P033 sequencing primer


<400>    38
caacgtgaaa aaattattat tcgc                                                24


<210>    39
<211>    60
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VH-forward primer


<400>    39
ggagacccaa gcttggtacc gagctcggat ccactagtaa cggccgccag tgtgctggaa         60

                                                                          60


<210>    40
<211>    42
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VH-reverse primer


<400>    40
gaagaccgat gggcccttgg tggaggctga ggagacggtg ac                            42


<210>    41
<211>    45
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VL-forward primer


<400>    41
tagggagacc cgctagcgga gcaagatgga ttcacaggcc caggt                         45


<210>    42
<211>    45
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    VL-reverse primer


<400>    42
tatagaatag ggccccccct cgaggtcgac ctaacactct cccct                         45


<210>    43
<211>    330
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Heavy chain constant region of human antibody


<400>    43
Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Ser Ser Lys
  1               5                  10                  15 

Ser Thr Ser Gly Gly Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr
             20                  25                  30 

Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser
         35                  40                  45 

Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser
     50                  55                  60 

Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Gln Thr
 65                  70                  75                  80 

Tyr Ile Cys Asn Val Asn His Lys Pro Ser Asn Thr Lys Val Asp Lys
                 85                  90                  95 

Lys Val Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys
            100                 105                 110 

Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro
        115                 120                 125 

Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys
    130                 135                 140 

Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp
145                 150                 155                 160 

Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu
                165                 170                 175 

Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu
            180                 185                 190 

His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn
        195                 200                 205 

Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly
    210                 215                 220 

Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu
225                 230                 235                 240 

Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr
                245                 250                 255 

Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn
            260                 265                 270 

Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe
        275                 280                 285 

Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn
    290                 295                 300 

Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr
305                 310                 315                 320 

Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys
                325                 330


<210>    44
<211>    106
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Light chain constant region of human antibody


<400>    44
Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln
  1               5                  10                  15 

Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr
             20                  25                  30 

Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser
         35                  40                  45 

Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr
     50                  55                  60 

Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys
 65                  70                  75                  80 

His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro
                 85                  90                  95 

Val Thr Lys Ser Phe Asn Arg Gly Glu Cys
            100                 105    



