                         SEQUENCE LISTING

<110>  ACTELION PHARMACEUTICALS LTD
 
<120>  NATURAL PEPTIDE AND DERIVATIVES AS MODULATORS OF GPCR GPR1 AND 
       USES THEREOF

<130>  Act 212A

<150>  PCT/IB2009/054324
<151>  2009-10-02

<160>  14    

<170>  PatentIn version 3.3

<210>  1
<211>  1068
<212>  DNA
<213>  homo sapiens

<400>  1
atggaagatt tggaggaaac attatttgaa gaatttgaga actattccta tgacctagac     60

tattactctc tggagtctga tttggaggag aaagtccagc tgggagttgt tcactgggtc    120

tccctggtgt tatattgttt ggcttttgtt ctgggaattc caggaaatgc catcgtcatt    180

tggttcacgg ggttcaagtg gaagaagaca gtcaccactc tgtggttcct caatctagcc    240

attgcggatt tcatttttct tctctttctg cccctgtaca tctcctatgt ggccatgaat    300

ttccactggc cctttggcat ctggctgtgc aaagccaatt ccttcactgc ccagttgaac    360

atgtttgcca gtgttttttt cctgacagtg atcagcctgg accactatat ccacttgatc    420

catcctgtct tatctcatcg gcatcgaacc ctcaagaact ctctgattgt cattatattc    480

atctggcttt tggcttctct aattggcggt cctgccctgt acttccggga tactgtggag    540

ttcaataatc atactctttg ctataacaat tttcagaagc atgatcctga cctcactttg    600

atcaggcacc atgttctgac ttgggtgaaa tttatcattg gctatctctt ccctttgcta    660

acaatgagta tttgctactt gtgtctcatc ttcaaggtga agaagcgaag catcctgatc    720

tccagtaggc atttctggac aattctggtt gtggttgtgg cctttgtggt ttgctggact    780

ccttatcacc tgtttagcat ttgggagctc accattcacc acaatagcta ttcccaccat    840

gtgatgcagg ctggaatccc cctctccact ggtttggcat tcctcaatag ttgcttgaac    900

cccatccttt atgtcctagt tagtaagaag ttccaagctc gcttccggtc ctcagttgct    960

gagatactca agtacacact gtgggaagtc agctgttctg gcacagtgag tgaacagctc   1020

aggaactcag aaaccaagaa tctgtgtctc ctggaaacag ctcaataa                1068


<210>  2
<211>  353
<212>  PRT
<213>  homo sapiens

<400>  2

Met Glu Asp Leu Glu Glu Thr Leu Phe Glu Glu Phe Glu Asn Tyr Ser 
1               5                   10                  15      


Tyr Asp Leu Asp Tyr Tyr Ser Leu Glu Ser Asp Leu Glu Glu Lys Val 
            20                  25                  30          


Gln Leu Gly Val Val His Trp Val Ser Leu Val Leu Tyr Cys Leu Ala 
        35                  40                  45              


Phe Val Leu Gly Ile Pro Gly Asn Ala Ile Val Ile Trp Phe Thr Gly 
    50                  55                  60                  


Phe Lys Trp Lys Lys Thr Val Thr Thr Leu Trp Phe Leu Asn Leu Ala 
65                  70                  75                  80  


Ile Ala Asp Phe Ile Phe Leu Leu Phe Leu Pro Leu Tyr Ile Ser Tyr 
                85                  90                  95      


Val Ala Met Asn Phe His Trp Pro Phe Gly Ile Trp Leu Cys Lys Ala 
            100                 105                 110         


Asn Ser Phe Thr Ala Gln Leu Asn Met Phe Ala Ser Val Phe Phe Leu 
        115                 120                 125             


Thr Val Ile Ser Leu Asp His Tyr Ile His Leu Ile His Pro Val Leu 
    130                 135                 140                 


Ser His Arg His Arg Thr Leu Lys Asn Ser Leu Ile Val Ile Ile Phe 
145                 150                 155                 160 


Ile Trp Leu Leu Ala Ser Leu Ile Gly Gly Pro Ala Leu Tyr Phe Arg 
                165                 170                 175     


Asp Thr Val Glu Phe Asn Asn His Thr Leu Cys Tyr Asn Asn Phe Gln 
            180                 185                 190         


Lys His Asp Pro Asp Leu Thr Leu Ile Arg His His Val Leu Thr Trp 
        195                 200                 205             


Val Lys Phe Ile Ile Gly Tyr Leu Phe Pro Leu Leu Thr Met Ser Ile 
    210                 215                 220                 


Cys Tyr Leu Cys Leu Ile Phe Lys Val Lys Lys Arg Ser Ile Leu Ile 
225                 230                 235                 240 


Ser Ser Arg His Phe Thr Ile Leu Val Val Val Val Ala Phe Val Val 
                245                 250                 255     


Cys Trp Thr Pro Tyr His Leu Phe Ser Ile Trp Glu Leu Thr Ile His 
            260                 265                 270         


His Asn Ser Tyr Ser His His Val Met Gln Ala Gly Ile Pro Leu Ser 
        275                 280                 285             


Thr Gly Leu Ala Phe Leu Asn Ser Cys Leu Asn Pro Ile Leu Tyr Val 
    290                 295                 300                 


Leu Ile Ser Lys Phe Gln Ala Arg Phe Arg Ser Ser Val Ala Glu Ile 
305                 310                 315                 320 


Leu Lys Tyr Thr Leu Trp Glu Val Ser Cys Ser Gly Thr Val Ser Glu 
                325                 330                 335     


Gln Leu Arg Asn Ser Glu Thr Lys Asn Leu Cys Leu Leu Glu Thr Ala 
            340                 345                 350         


Gln 
    


<210>  3
<211>  1062
<212>  DNA
<213>  mouse

<400>  3
atggaagtct caaaggaaat gttatttgag gagttggaca actattccta tgccttagat     60

tattactccc aggagtctga cccggaggag aaggtgtacc tgggactcgt tcactggatc    120

tccctgttct tatatgccct agcatttgtt ctgggcatcc caggaaatgc catcgtcatt    180

tggctcatgg gattcaagtg gaagaagaca gtcaccactc tttggttcct caatctggcc    240

atcgcagact tcatctttgt tctcttcctg cccctgtaca tttcctacgt ggccttgagt    300

ttccactggc cctttggcct gtggctctgc aaggttaatt ccttcattgc ccaactgaac    360

atgttttcca gtgttttctt cttgacagtg atcagcctgg accgctacat ccacttgctc    420

catcctggct tgtctcatcg gcaccggact ctaaagagct cactggttgt tgttatactt    480

gtctggctgt tggcttctct gcttggaggt cctaccttat acttccggga caccatggag    540

gtcaacaacc acatcatttg ttataataat ttccaggagc atgaactcac cttgatgaga    600

caccatgttc tgacctgggt gaagttcctc tttggctacc tcttcccttt gctaaccatg    660

agctcctgct acttgtgcct catcttcaag atgaaaaagc ggaacatcct gatatctaga    720

aagcatctct ggatgatcct gtctgtggtc attgccttct tggtttgctg gaccccttat    780

cacctgttta gcatctggga gctcagcatt catcacaaca gctctttcca gaatgtgctg    840

cagggtggaa tccccctctc aactggctta gccttcctca atagctgctt gaatcccatc    900

ctttacgtcc taataagcaa gacgttccaa gcccgcttca gggcctctgt tgctgaggta    960

ctaaagcgtt cgctgtggga agccagctgc tctggtacag tcagtgaaca actcaggagt   1020

gctgaaacca agagcctgtc tctcctagaa actgcccagt ga                      1062


<210>  4
<211>  353
<212>  PRT
<213>  mouse

<400>  4

Met Glu Val Ser Lys Glu Met Leu Phe Glu Glu Leu Asp Asn Tyr Ser 
1               5                   10                  15      


Tyr Ala Leu Asp Tyr Tyr Ser Gln Glu Ser Asp Pro Glu Glu Lys Val 
            20                  25                  30          


Tyr Leu Gly Leu Val His Trp Ile Ser Leu Phe Leu Tyr Ala Leu Ala 
        35                  40                  45              


Phe Val Leu Gly Ile Pro Gly Asn Ala Ile Val Ile Trp Leu Met Gly 
    50                  55                  60                  


Phe Lys Trp Lys Lys Thr Val Thr Thr Leu Trp Phe Leu Asn Leu Ala 
65                  70                  75                  80  


Ile Ala Asp Phe Ile Phe Val Leu Phe Leu Pro Leu Tyr Ile Ser Tyr 
                85                  90                  95      


Val Ala Leu Ser Phe His Trp Pro Phe Gly Leu Trp Leu Cys Lys Val 
            100                 105                 110         


Asn Ser Phe Ile Ala Gln Leu Asn Met Phe Ser Ser Val Phe Phe Leu 
        115                 120                 125             


Thr Val Ile Ser Leu Asp Arg Tyr Ile His Leu Leu His Pro Gly Leu 
    130                 135                 140                 


Ser His Arg His Arg Thr Leu Lys Ser Ser Leu Val Val Val Ile Leu 
145                 150                 155                 160 


Val Trp Leu Leu Ala Ser Leu Leu Gly Gly Pro Thr Leu Tyr Phe Arg 
                165                 170                 175     


Asp Thr Met Glu Val Asn Asn His Ile Ile Cys Tyr Asn Asn Phe Gln 
            180                 185                 190         


Glu His Glu Leu Thr Leu Met Arg His His Val Leu Thr Trp Val Lys 
        195                 200                 205             


Phe Leu Phe Gly Tyr Leu Phe Pro Leu Leu Thr Met Ser Ser Cys Tyr 
    210                 215                 220                 


Leu Cys Leu Ile Phe Lys Met Lys Lys Arg Asn Ile Leu Ile Ser Arg 
225                 230                 235                 240 


Lys His Leu Trp Met Ile Leu Ser Val Val Ile Ala Phe Leu Val Cys 
                245                 250                 255     


Trp Thr Pro Tyr His Leu Phe Ser Ile Trp Glu Leu Ser Ile His His 
            260                 265                 270         


Asn Ser Ser Phe Gln Asn Val Leu Gln Gly Gly Ile Pro Leu Ser Thr 
        275                 280                 285             


Gly Leu Ala Phe Leu Asn Ser Cys Leu Asn Pro Ile Leu Tyr Val Leu 
    290                 295                 300                 


Ile Ser Lys Thr Phe Gln Ala Arg Phe Arg Ala Ser Val Ala Glu Val 
305                 310                 315                 320 


Leu Lys Arg Ser Leu Trp Glu Ala Ser Cys Ser Gly Thr Val Ser Glu 
                325                 330                 335     


Gln Leu Arg Ser Ala Glu Thr Lys Ser Leu Ser Leu Leu Glu Thr Ala 
            340                 345                 350         


Gln 
    


<210>  5
<211>  1062
<212>  DNA
<213>  rat

<400>  5
atggaagtct caagggaaat gctatttgaa gaactggaca actactccta tgccttagaa     60

tattactccc aggaacctga cgcagaggag aatgtgtacc cgggaatcgt tcactggatc    120

tccctgctct tatatgccct tgcgtttgtt ctgggaattc cagggaatgc catcgtcatt    180

tggttcatgg gattcaagtg gaagaagacg gtcaccactc tttggtttct caatctagcc    240

attgcggatt tcatctttgt tctcttcctg cctctgtata tttcctatgt ggcactgagt    300

ttccactggc cctttgggcg atggctctgc aagcttaatt ccttcattgc ccaactgaac    360

atgttttcca gtgtattctt cttgacagtg attagcctgg accgctacat tcacttgatc    420

caccctggct tgtctcatcc gcaccggacc ctgaagaact cactgcttgt tgttctattt    480

gtctggctgt tggcttctct gctcggaggt cctaccctgt acttccggga caccgtggag    540

gtcaacaacc gcattatttg ttataacaac ttccaggagt atgagctcac cctgatgaga    600

caccacgttc tgacctgggt gaagttcctt tttggctacc tcttgccttt gctgacaatg    660

agctcctgct acctgtgcct catcttcaag acgaagaagc aaaacattct gatatccagt    720

aagcatctct ggatgatcct gtctgtggtc atcgccttca tggtttgctg gactcctttt    780

cacctgttca gcatttggga actcagcatt catcacaaca gctctttcca gaacgtgctg    840

cagggcggaa tccctctctc tactggcttg gccttcctca atagttgctt gaaccccatc    900

ctttacgtta taataagcaa gaagtttcaa gctcgattca gggcctctgt tgccgaggta    960

ctaaagcggt cactgtggga ggccagttgc tctggtacag tgagtgaaca actcaggagt   1020

gctgaaacca agagcctgtc tctcctagaa actgcccaat ga                      1062


<210>  6
<211>  353
<212>  PRT
<213>  rat

<400>  6

Met Glu Val Ser Arg Glu Met Leu Phe Glu Glu Leu Asp Asn Tyr Ser 
1               5                   10                  15      


Tyr Ala Leu Glu Tyr Tyr Ser Gln Glu Pro Asp Ala Glu Glu Asn Val 
            20                  25                  30          


Tyr Pro Gly Ile Val His Trp Ile Ser Leu Leu Leu Tyr Ala Leu Ala 
        35                  40                  45              


Phe Val Leu Gly Ile Pro Gly Asn Ala Ile Val Ile Trp Phe Met Gly 
    50                  55                  60                  


Phe Lys Trp Lys Lys Thr Val Thr Thr Leu Trp Phe Leu Asn Leu Ala 
65                  70                  75                  80  


Ile Ala Asp Phe Ile Phe Val Leu Phe Leu Pro Leu Tyr Ile Ser Tyr 
                85                  90                  95      


Val Ala Leu Ser Phe His Trp Pro Phe Gly Arg Trp Leu Cys Lys Leu 
            100                 105                 110         


Asn Ser Phe Ile Ala Gln Leu Asn Met Phe Ser Ser Val Phe Phe Leu 
        115                 120                 125             


Thr Val Ile Ser Leu Asp Arg Tyr Ile His Leu Ile His Pro Gly Leu 
    130                 135                 140                 


Ser His Pro His Arg Thr Leu Lys Asn Ser Leu Leu Val Val Leu Phe 
145                 150                 155                 160 


Val Trp Leu Leu Ala Ser Leu Leu Gly Gly Pro Thr Leu Tyr Phe Arg 
                165                 170                 175     


Asp Thr Val Glu Val Asn Asn Arg Ile Ile Cys Tyr Asn Asn Phe Gln 
            180                 185                 190         


Glu Tyr Glu Leu Thr Leu Met Arg His His Val Leu Thr Trp Val Lys 
        195                 200                 205             


Phe Leu Phe Gly Tyr Leu Leu Pro Leu Leu Thr Met Ser Ser Cys Tyr 
    210                 215                 220                 


Leu Cys Leu Ile Phe Lys Thr Lys Lys Gln Asn Ile Leu Ile Ser Ser 
225                 230                 235                 240 


Lys His Leu Trp Met Ile Leu Ser Val Val Ile Ala Phe Met Val Cys 
                245                 250                 255     


Trp Thr Pro Phe His Leu Phe Ser Ile Trp Glu Leu Ser Ile His His 
            260                 265                 270         


Asn Ser Ser Phe Gln Asn Val Leu Gln Gly Gly Ile Pro Leu Ser Thr 
        275                 280                 285             


Gly Leu Ala Phe Leu Asn Ser Cys Leu Asn Pro Ile Leu Tyr Val Ile 
    290                 295                 300                 


Ile Ser Lys Lys Phe Gln Ala Arg Phe Arg Ala Ser Val Ala Glu Val 
305                 310                 315                 320 


Leu Lys Arg Ser Leu Trp Glu Ala Ser Cys Ser Gly Thr Val Ser Glu 
                325                 330                 335     


Gln Leu Arg Ser Ala Glu Thr Lys Ser Leu Ser Leu Leu Glu Thr Ala 
            340                 345                 350         


Gln 
    


<210>  7
<211>  1068
<212>  DNA
<213>  rhesus macaque

<400>  7
atggaagatt tggaggaaac attatttgaa gaatttgaaa actattccta tgccctagac     60

tattactctc tggagtctga tttggaggaa aaagtccagc tgggagttgt tcactgggtc    120

tccctggtgt tatattgttt atcttttgtc ctgggaattc caggaaatgc cattgttatt    180

tggttcacgg ggttcaagtg gaagaagaca gtcagcactc tgtggttcct caatctagcc    240

attgcggatt tcatctttct tctcttcctg cccctgtaca tctcctatgt ggtcatgaat    300

ttccactggc cctttggcat ctggctgtgc aaagccaatt ccttcactgc ccagttgaac    360

atgtttgcca gtgttttttt cctgacagtg atcagtctgg accactatat ccacttgatc    420

catcctgtct tatctcatcg gcatcgaacc ctcaagaact ctctgattgt cattatattc    480

atctggcttt tggcttctct aattggcggt cctgccctat acttccggga cactgtggag    540

tttaataatc atactctttg ctataacaat tttcagaagc atgatcctga cctcactgtg    600

atcaggcacc atgttctgac ctgggtgaaa tttattgttg gctatctctt ccctttgcta    660

acaatgagta tttgctactt gtgtctcatc ttcaaggtga agaagcgaag catcctgatc    720

tccagtaggc atttctggac aattctggct gtggttgtgg cctttgtggt ttgctggact    780

ccttatcacc tgtttagcat ttgggagctc accattcacc acaatagcta ttcccaccac    840

gtgatgcagg ctggaatccc tctctccact ggtttggcat tcctcaatag ttgcttgaac    900

cccatccttt atgtcctaat tagtaagaag ttccaagctc gcttccggtc ctcagttgct    960

gagatactca agtacacact gtgggaagtc agctgttctg gcacagtgag tgaacagctc   1020

aggaactcag aaaccaagaa tctgtgtctc ctggaaacag cccaataa                1068


<210>  8
<211>  355
<212>  PRT
<213>  rhesus macaque

<400>  8

Met Glu Asp Leu Glu Glu Thr Leu Phe Glu Glu Phe Glu Asn Tyr Ser 
1               5                   10                  15      


Tyr Ala Leu Asp Tyr Tyr Ser Leu Glu Ser Asp Leu Glu Glu Lys Val 
            20                  25                  30          


Gln Leu Gly Val Val His Trp Val Ser Leu Val Leu Tyr Cys Leu Ser 
        35                  40                  45              


Phe Val Leu Gly Ile Pro Gly Asn Ala Ile Val Ile Trp Phe Thr Gly 
    50                  55                  60                  


Phe Lys Trp Lys Lys Thr Val Ser Thr Leu Trp Phe Leu Asn Leu Ala 
65                  70                  75                  80  


Ile Ala Asp Phe Ile Phe Leu Leu Phe Leu Pro Leu Tyr Ile Ser Tyr 
                85                  90                  95      


Val Val Met Asn Phe His Trp Pro Phe Gly Ile Trp Leu Cys Lys Ala 
            100                 105                 110         


Asn Ser Phe Thr Ala Gln Leu Asn Met Phe Ala Ser Val Phe Phe Leu 
        115                 120                 125             


Thr Val Ile Ser Leu Asp His Tyr Ile His Leu Ile His Pro Val Leu 
    130                 135                 140                 


Ser His Arg His Arg Thr Leu Lys Asn Ser Leu Ile Val Ile Ile Phe 
145                 150                 155                 160 


Ile Trp Leu Leu Ala Ser Leu Ile Gly Gly Pro Ala Leu Tyr Phe Arg 
                165                 170                 175     


Asp Thr Val Glu Phe Asn Asn His Thr Leu Cys Tyr Asn Asn Phe Gln 
            180                 185                 190         


Lys His Asp Pro Asp Leu Thr Val Ile Arg His His Val Leu Thr Trp 
        195                 200                 205             


Val Lys Phe Ile Val Gly Tyr Leu Phe Pro Leu Leu Thr Met Ser Ile 
    210                 215                 220                 


Cys Tyr Leu Cys Leu Ile Phe Lys Val Lys Lys Arg Ser Ile Leu Ile 
225                 230                 235                 240 


Ser Ser Arg His Phe Trp Thr Ile Leu Ala Val Val Val Ala Phe Val 
                245                 250                 255     


Val Cys Trp Thr Pro Tyr His Leu Phe Ser Ile Trp Glu Leu Thr Ile 
            260                 265                 270         


His His Asn Ser Tyr Ser His His Val Met Gln Ala Gly Ile Pro Leu 
        275                 280                 285             


Ser Thr Gly Leu Ala Phe Leu Asn Ser Cys Leu Asn Pro Ile Leu Tyr 
    290                 295                 300                 


Val Leu Ile Ser Lys Lys Phe Gln Ala Arg Phe Arg Ser Ser Val Ala 
305                 310                 315                 320 


Glu Ile Leu Lys Tyr Thr Leu Trp Glu Val Ser Cys Ser Gly Thr Val 
                325                 330                 335     


Ser Glu Gln Leu Arg Asn Ser Glu Thr Lys Asn Leu Cys Leu Leu Glu 
            340                 345                 350         


Thr Ala Gln 
        355 


<210>  9
<211>  1068
<212>  DNA
<213>  cynomolgus monkey

<400>  9
atggaagatt tggaggaaac attatttgaa gaatttgaaa actattccta tgccctagac     60

tattactctc tggagtctga tttggaggaa aaagtccagc tgggagttgt tcactgggtc    120

tccctggtgt tatattgttt atcttttgtc ctgggaattc caggaaatgc cattgttatt    180

tggttcaccg ggttcaagtg gaagaggaca gtcagcactc tgtggttcct caatctagcc    240

attgcggatt tcatctttct tctcttcctg cccctgtaca tctcctatgt ggtcatgaat    300

ttccactggc cctttggcat ctggctgtgc aaagccaatt ccttcactgc ccagttgaac    360

atgtttgcca gtgttttttt cctgacagtg atcagtctgg accactatat ccacttgatc    420

catcctgtct tatctcatcg gcatcgaacc ctcaagaact ctctgattgt cattatattc    480

atctggcttt tggcttctct aattggtggt cctgccctat acttccggga cactgtggag    540

tttaataatc atactctttg ctataacaat tttcagaagc atgatcccga cctcactgtg    600

atcaggcacc atgttctgac ctgggtgaaa tatattgttg gctatctctt ccctttgcta    660

acaatgagta tttgctactt gtgtctcatc ctcaaggtga agaagcgaag catcctgatc    720

tccagtaggc atttctggac aattctggct gtggttgtgg cctttgtggt ttgctggact    780

ccttatcacc tgtttagcat ttgggagctc accattcacc acaatagcta ttcccaccac    840

gtgatgcagg ctggaatccc tctctccact ggtttggcat tcctcaatag ttgcttgaac    900

cccatccttt atgtcctaat tagtaagaag ttccaagctc gcttccggtc ctcagttgct    960

gagatactca agtacacact gtgggaagtc agctgttctg gcacagtgag tgaacagctc   1020

aggaactcag aaaccaagaa tctgtgtctc ctggaaacag cccaataa                1068


<210>  10
<211>  355
<212>  PRT
<213>  cynomolgus monkey

<400>  10

Met Glu Asp Leu Glu Glu Thr Leu Phe Glu Glu Phe Glu Asn Tyr Ser 
1               5                   10                  15      


Tyr Ala Leu Asp Tyr Tyr Ser Leu Glu Ser Asp Leu Glu Glu Lys Val 
            20                  25                  30          


Gln Leu Gly Val Val His Trp Val Ser Leu Val Leu Tyr Cys Leu Ser 
        35                  40                  45              


Phe Val Leu Gly Ile Pro Gly Asn Ala Ile Val Ile Trp Phe Thr Gly 
    50                  55                  60                  


Phe Lys Trp Lys Arg Thr Val Ser Thr Leu Trp Phe Leu Asn Leu Ala 
65                  70                  75                  80  


Ile Ala Asp Phe Ile Phe Leu Leu Phe Leu Pro Leu Tyr Ile Ser Tyr 
                85                  90                  95      


Val Val Met Asn Phe His Trp Pro Phe Gly Ile Trp Leu Cys Lys Ala 
            100                 105                 110         


Asn Ser Phe Thr Ala Gln Leu Asn Met Phe Ala Ser Val Phe Phe Leu 
        115                 120                 125             


Thr Val Ile Ser Leu Asp His Tyr Ile His Leu Ile His Pro Val Leu 
    130                 135                 140                 


Ser His Arg His Arg Thr Leu Lys Asn Ser Leu Ile Val Ile Ile Phe 
145                 150                 155                 160 


Ile Trp Leu Leu Ala Ser Leu Ile Gly Gly Pro Ala Leu Tyr Phe Arg 
                165                 170                 175     


Asp Thr Val Glu Phe Asn Asn His Thr Leu Cys Tyr Asn Asn Phe Gln 
            180                 185                 190         


Lys His Asp Pro Asp Leu Thr Val Ile Arg His His Val Leu Thr Trp 
        195                 200                 205             


Val Lys Tyr Ile Val Gly Tyr Leu Phe Pro Leu Leu Thr Met Ser Ile 
    210                 215                 220                 


Cys Tyr Leu Cys Leu Ile Leu Lys Val Lys Lys Arg Ser Ile Leu Ile 
225                 230                 235                 240 


Ser Ser Arg His Phe Trp Thr Ile Leu Ala Val Val Val Ala Phe Val 
                245                 250                 255     


Val Cys Trp Thr Pro Tyr His Leu Phe Ser Ile Trp Glu Leu Thr Ile 
            260                 265                 270         


His His Asn Ser Tyr Ser His His Val Met Gln Ala Gly Ile Pro Leu 
        275                 280                 285             


Ser Thr Gly Leu Ala Phe Leu Asn Ser Cys Leu Asn Pro Ile Leu Tyr 
    290                 295                 300                 


Val Leu Ile Ser Lys Lys Phe Gln Ala Arg Phe Arg Ser Ser Val Ala 
305                 310                 315                 320 


Glu Ile Leu Lys Tyr Thr Leu Trp Glu Val Ser Cys Ser Gly Thr Val 
                325                 330                 335     


Ser Glu Gln Leu Arg Asn Ser Glu Thr Lys Asn Leu Cys Leu Leu Glu 
            340                 345                 350         


Thr Ala Gln 
        355 


<210>  11
<211>  75
<212>  DNA
<213>  homo sapiens

<400>  11
atggctccac gagggttcag ctgtctctta cttttaacca gtgaaattga cctgcccgtg     60

aagaggcggg catga                                                      75


<210>  12
<211>  24
<212>  PRT
<213>  homo sapiens

<400>  12

Met Ala Pro Arg Gly Phe Ser Cys Leu Leu Leu Leu Thr Ser Glu Ile 
1               5                   10                  15      


Asp Leu Pro Val Lys Arg Arg Ala 
            20                  


<210>  13
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Gly14-Humanin

<400>  13

Met Ala Pro Arg Gly Phe Ser Cys Leu Leu Leu Leu Thr Gly Glu Ile 
1               5                   10                  15      


Asp Leu Pro Val Lys Arg Arg Ala 
            20                  


<210>  14
<211>  24
<212>  PRT
<213>  Artificial

<220>
<223>  Ala8-Humanin

<400>  14

Met Ala Pro Arg Gly Phe Ser Ala Leu Leu Leu Leu Thr Ser Glu Ile 
1               5                   10                  15      


Asp Leu Pro Val Lys Arg Arg Ala 
            20                  


