                         SEQUENCE LISTING

<110>  SANOFI-AVENTIS
 
<120>  NEW ANTAGONIST ANTIBODY TARGETING EPHA2 FOR THE TREATMENT OF 
       CANCER

<130>  FR2009-082 PCT

<160>  19    

<170>  PatentIn version 3.3

<210>  1
<211>  5
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Tyr Tyr Met His 
1               5   


<210>  2
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  2

Leu Val Asn Pro Tyr Asn Gly Phe Ser Ser Tyr Asn Gln Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  3

Glu Phe Tyr Gly Tyr Arg Tyr Phe Asp Val 
1               5                   10  


<210>  4
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  4

Lys Ser Ser Gln Ser Leu Ile His Ser Asp Gly Arg Thr Tyr Leu Asn 
1               5                   10                  15      


<210>  5
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  5

Leu Val Ser Arg Leu Asp Ser 
1               5           


<210>  6
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  6

Trp Gln Gly Ser His Phe Pro Arg Thr 
1               5                   


<210>  7
<211>  357
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(357)

<400>  7
gag gtc cag ctg caa cag tct gga cct gag ctg gtg aag cct ggg gct       48
Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala         
1               5                   10                  15              

tca gtg aag att tcc tgc aag gct tct ggt tac tca ttc act gcc tac       96
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ala Tyr         
            20                  25                  30                  

tac atg cac tgg gtg aag caa agt cat gta aag agt ctt gag tgg att      144
Tyr Met His Trp Val Lys Gln Ser His Val Lys Ser Leu Glu Trp Ile         
        35                  40                  45                      

gga ctt gtt aat cct tac aat ggt ttt agt agc tac aac cag aat ttc      192
Gly Leu Val Asn Pro Tyr Asn Gly Phe Ser Ser Tyr Asn Gln Asn Phe         
    50                  55                  60                          

gag gac aag gcc agc ttg act gta gat aga ttc tcc agc acc gcc tac      240
Glu Asp Lys Ala Ser Leu Thr Val Asp Arg Phe Ser Ser Thr Ala Tyr         
65                  70                  75                  80          

atg gaa ctc cac agc ctg aca tct gag gac tct gca gtc tat tac tgt      288
Met Glu Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys         
                85                  90                  95              

gca aga gaa ttc tac ggc tac cgg tac ttc gat gtc tgg ggc gca ggg      336
Ala Arg Glu Phe Tyr Gly Tyr Arg Tyr Phe Asp Val Trp Gly Ala Gly         
            100                 105                 110                 

acc gcg gtc acc gtc tcc tca                                          357
Thr Ala Val Thr Val Ser Ser                                             
        115                                                             


<210>  8
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  8

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Ser Phe Thr Ala Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ser His Val Lys Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Val Asn Pro Tyr Asn Gly Phe Ser Ser Tyr Asn Gln Asn Phe 
    50                  55                  60                  


Glu Asp Lys Ala Ser Leu Thr Val Asp Arg Phe Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Phe Tyr Gly Tyr Arg Tyr Phe Asp Val Trp Gly Ala Gly 
            100                 105                 110         


Thr Ala Val Thr Val Ser Ser 
        115                 


<210>  9
<211>  339
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(339)

<400>  9
gat gtt gtg atg acc cag act cca ctc act ttg tcg gtt acc att gga       48
Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly         
1               5                   10                  15              

caa cca gcc tcc atc tct tgc aag tca agt cag agc ctc ata cat agt       96
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Ile His Ser         
            20                  25                  30                  

gat gga aga aca tat ttg aat tgg ttg tta cag agg cca ggc cag tct      144
Asp Gly Arg Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser         
        35                  40                  45                      

cca aag cgc cta att tat ctg gtg tct aga ctg gac tct gga gtc cct      192
Pro Lys Arg Leu Ile Tyr Leu Val Ser Arg Leu Asp Ser Gly Val Pro         
    50                  55                  60                          

gac agg ttc act ggc agt gga tca ggg aca gat ttc aca ctg aaa atc      240
Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

agc aga gtg gag gct gag gat ttg gga gtt tat tat tgc tgg caa ggt      288
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly         
                85                  90                  95              

tca cat ttt cct cgg acg ttc ggt gga ggc acc aag ctg gaa atc aaa      336
Ser His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys         
            100                 105                 110                 

cgg                                                                  339
Arg                                                                     
                                                                        


<210>  10
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  10

Asp Val Val Met Thr Gln Thr Pro Leu Thr Leu Ser Val Thr Ile Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Ile His Ser 
            20                  25                  30          


Asp Gly Arg Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Arg Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Ser His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  11
<211>  357
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(357)

<400>  11
cag gtg caa ctg gtg caa tcc ggt gcc gag gtc gtc aaa ccc gga gca       48
Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala         
1               5                   10                  15              

tct gtg aag ata tcc tgt aag gcc tcc ggc tac act ttt aca gcc tac       96
Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ala Tyr         
            20                  25                  30                  

tat atg cat tgg gtt aaa cag agt ccc gtg cag tcc ctg gaa tgg atc      144
Tyr Met His Trp Val Lys Gln Ser Pro Val Gln Ser Leu Glu Trp Ile         
        35                  40                  45                      

ggc ttg gtg aac cct tat aac gga ttc tca agt tac aat caa aag ttt      192
Gly Leu Val Asn Pro Tyr Asn Gly Phe Ser Ser Tyr Asn Gln Lys Phe         
    50                  55                  60                          

cag ggc aag gct tcc ctg act gta gac aga tct agt tcc aca gcc tac      240
Gln Gly Lys Ala Ser Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr         
65                  70                  75                  80          

atg gag ctc cat tca ctg aca tca gaa gac agc gcc gta tac tat tgc      288
Met Glu Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys         
                85                  90                  95              

gca cgt gag ttc tac ggc tat aga tac ttt gac gtc tgg ggc caa ggc      336
Ala Arg Glu Phe Tyr Gly Tyr Arg Tyr Phe Asp Val Trp Gly Gln Gly         
            100                 105                 110                 

aca gcc gtc aca gtg agc tct                                          357
Thr Ala Val Thr Val Ser Ser                                             
        115                                                             


<210>  12
<211>  119
<212>  PRT
<213>  Homo sapiens

<400>  12

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ala Tyr 
            20                  25                  30          


Tyr Met His Trp Val Lys Gln Ser Pro Val Gln Ser Leu Glu Trp Ile 
        35                  40                  45              


Gly Leu Val Asn Pro Tyr Asn Gly Phe Ser Ser Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Ser Leu Thr Val Asp Arg Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Glu Phe Tyr Gly Tyr Arg Tyr Phe Asp Val Trp Gly Gln Gly 
            100                 105                 110         


Thr Ala Val Thr Val Ser Ser 
        115                 


<210>  13
<211>  336
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(336)

<400>  13
gac gtc gtg atg aca caa acc cct ctg tcc ctg agc gtc act ctg gga       48
Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Leu Gly         
1               5                   10                  15              

caa ccc gct tcc att agc tgc aaa tca tca caa tct ctc atc cac tca       96
Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Ile His Ser         
            20                  25                  30                  

gac ggc cgt acg tac ctc aat tgg ctg ctg cag aga cca gga cag tcc      144
Asp Gly Arg Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser         
        35                  40                  45                      

cct aaa agg ctt atc tac ctg gtc tct cgt ttg gac tct ggt gta cca      192
Pro Lys Arg Leu Ile Tyr Leu Val Ser Arg Leu Asp Ser Gly Val Pro         
    50                  55                  60                          

gac cgg ttt act ggt tcc ggg gcc gga acc gat ttc act ctg aag att      240
Asp Arg Phe Thr Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile         
65                  70                  75                  80          

tcc agg gtg gaa gct gaa gat ctc gga gtg tat tat tgc tgg cag ggc      288
Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly         
                85                  90                  95              

agc cat ttc ccc cgt act ttt ggt ggg ggt acc aaa ttg gaa att aag      336
Ser His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys         
            100                 105                 110                 


<210>  14
<211>  112
<212>  PRT
<213>  Homo sapiens

<400>  14

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val Thr Leu Gly 
1               5                   10                  15      


Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu Ile His Ser 
            20                  25                  30          


Asp Gly Arg Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Arg Leu Ile Tyr Leu Val Ser Arg Leu Asp Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Thr Gly Ser Gly Ala Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys Trp Gln Gly 
                85                  90                  95      


Ser His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


<210>  15
<211>  717
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(717)

<400>  15
atg gga tgg tct tgc atc atc ctg ttt ctc gtg gct act gcc acc gga       48
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly         
1               5                   10                  15              

gtg cac agt gac gtc gtg atg aca caa acc cct ctg tcc ctg agc gtc       96
Val His Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val         
            20                  25                  30                  

act ctg gga caa ccc gct tcc att agc tgc aaa tca tca caa tct ctc      144
Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu         
        35                  40                  45                      

atc cac tca gac ggc cgt acg tac ctc aat tgg ctg ctg cag aga cca      192
Ile His Ser Asp Gly Arg Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro         
    50                  55                  60                          

gga cag tcc cct aaa agg ctt atc tac ctg gtc tct cgt ttg gac tct      240
Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Arg Leu Asp Ser         
65                  70                  75                  80          

ggt gta cca gac cgg ttt act ggt tcc ggg gcc gga acc gat ttc act      288
Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ala Gly Thr Asp Phe Thr         
                85                  90                  95              

ctg aag att tcc agg gtg gaa gct gaa gat ctc gga gtg tat tat tgc      336
Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys         
            100                 105                 110                 

tgg cag ggc agc cat ttc ccc cgt act ttt ggt ggg ggt acc aaa ttg      384
Trp Gln Gly Ser His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu         
        115                 120                 125                     

gaa att aag cgt acg gtg gct gca cca tct gtc ttc atc ttc ccg cca      432
Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro         
    130                 135                 140                         

tct gat gag cag ttg aaa tct gga act gcc tct gtt gtg tgc ctg ctg      480
Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu         
145                 150                 155                 160         

aat aac ttc tat ccc aga gag gcc aaa gta cag tgg aag gtg gat aac      528
Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn         
                165                 170                 175             

gcc ctc caa tcg ggt aac tcc cag gag agt gtc aca gag cag gac agc      576
Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser         
            180                 185                 190                 

aag gac agc acc tac agc ctc agc agc acc ctg acg ctg agc aaa gca      624
Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala         
        195                 200                 205                     

gac tac gag aaa cac aaa gtc tac gcc tgc gaa gtc acc cat cag ggc      672
Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly         
    210                 215                 220                         

ctg agc tcg ccc gtc aca aag agc ttc aac agg gga gag tgt tag          717
Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys                 
225                 230                 235                             


<210>  16
<211>  238
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Ser Val 
            20                  25                  30          


Thr Leu Gly Gln Pro Ala Ser Ile Ser Cys Lys Ser Ser Gln Ser Leu 
        35                  40                  45              


Ile His Ser Asp Gly Arg Thr Tyr Leu Asn Trp Leu Leu Gln Arg Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Arg Leu Ile Tyr Leu Val Ser Arg Leu Asp Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ala Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Tyr Cys 
            100                 105                 110         


Trp Gln Gly Ser His Phe Pro Arg Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             


<210>  17
<211>  1404
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1404)

<400>  17
atg gga tgg tcc tgt att att ctg ttt ctc gtg gct aca gcc aca ggc       48
Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly         
1               5                   10                  15              

gtt cat agt cag gtg caa ctg gtg caa tcc ggt gcc gag gtc gtc aaa       96
Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys         
            20                  25                  30                  

ccc gga gca tct gtg aag ata tcc tgt aag gcc tcc ggc tac act ttt      144
Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe         
        35                  40                  45                      

aca gcc tac tat atg cat tgg gtt aaa cag agt ccc gtg cag tcc ctg      192
Thr Ala Tyr Tyr Met His Trp Val Lys Gln Ser Pro Val Gln Ser Leu         
    50                  55                  60                          

gaa tgg atc ggc ttg gtg aac cct tat aac gga ttc tca agt tac aat      240
Glu Trp Ile Gly Leu Val Asn Pro Tyr Asn Gly Phe Ser Ser Tyr Asn         
65                  70                  75                  80          

caa aag ttt cag ggc aag gct tcc ctg act gta gac aga tct agt tcc      288
Gln Lys Phe Gln Gly Lys Ala Ser Leu Thr Val Asp Arg Ser Ser Ser         
                85                  90                  95              

aca gcc tac atg gag ctc cat tca ctg aca tca gaa gac agc gcc gta      336
Thr Ala Tyr Met Glu Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val         
            100                 105                 110                 

tac tat tgc gca cgt gag ttc tac ggc tat aga tac ttt gac gtc tgg      384
Tyr Tyr Cys Ala Arg Glu Phe Tyr Gly Tyr Arg Tyr Phe Asp Val Trp         
        115                 120                 125                     

ggc caa ggc aca gcc gtc aca gtg agc tct gct tcc act aag ggc cca      432
Gly Gln Gly Thr Ala Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro         
    130                 135                 140                         

tcg gtc ttc ccc ctg gca ccc tcc tcc aag agc acc tct ggg ggc aca      480
Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr         
145                 150                 155                 160         

gcg gcc ctg ggc tgc ctg gtc aag gac tac ttc ccc gaa ccg gtg acg      528
Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr         
                165                 170                 175             

gtg tcg tgg aac tca ggc gcc ctg acc agc ggc gtg cac acc ttc ccg      576
Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro         
            180                 185                 190                 

gct gtc cta cag tcc tca gga ctc tac tcc ctc agc agc gtg gtg acc      624
Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr         
        195                 200                 205                     

gtg ccc tcc agc agc ttg ggc acc cag acc tac atc tgc aac gtg aat      672
Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn         
    210                 215                 220                         

cac aag ccc agc aac acc aag gtg gac aag aaa gtt gag ccc aaa tct      720
His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser         
225                 230                 235                 240         

tgt gac aaa act cac aca tgc cca ccg tgc cca gca cct gaa ctc ctg      768
Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu         
                245                 250                 255             

ggg gga ccg tca gtc ttc ctc ttc ccc cca aaa ccc aag gac acc ctc      816
Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu         
            260                 265                 270                 

atg atc tcc cgg acc cct gag gtc aca tgc gtg gtg gtg gac gtg agc      864
Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser         
        275                 280                 285                     

cac gaa gac cct gag gtc aag ttc aac tgg tac gtg gac ggc gtg gag      912
His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu         
    290                 295                 300                         

gtg cat aat gcc aag aca aag ccg cgg gag gag cag tac aac agc acg      960
Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr         
305                 310                 315                 320         

tac cgt gtg gtc agc gtc ctc acc gtc ctg cac cag gac tgg ctg aat     1008
Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn         
                325                 330                 335             

ggc aag gag tac aag tgc aag gtc tcc aac aaa gcc ctc cca gcc ccc     1056
Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro         
            340                 345                 350                 

atc gag aaa acc atc tcc aaa gcc aaa ggg cag ccc cga gaa cca cag     1104
Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln         
        355                 360                 365                     

gtg tac acc ctg ccc cca tcc cgg gat gag ctg acc aag aac cag gtc     1152
Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val         
    370                 375                 380                         

agc ctg acc tgc ctg gtc aaa ggc ttc tat ccc agc gac atc gcc gtg     1200
Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val         
385                 390                 395                 400         

gag tgg gag agc aat ggg cag ccg gag aac aac tac aag acc acg cct     1248
Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro         
                405                 410                 415             

ccc gtg ctg gac tcc gac ggc tcc ttc ttc ctc tac agc aag ctc acc     1296
Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr         
            420                 425                 430                 

gtg gac aag agc agg tgg cag cag ggg aac gtc ttc tca tgc tcc gtg     1344
Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val         
        435                 440                 445                     

atg cat gag gct ctg cac aac cac tac acg cag aag agc ctc tcc ctg     1392
Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu         
    450                 455                 460                         

tct ccg ggt tga                                                     1404
Ser Pro Gly                                                             
465                                                                     


<210>  18
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Gly Trp Ser Cys Ile Ile Leu Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Val Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Ala Tyr Tyr Met His Trp Val Lys Gln Ser Pro Val Gln Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Leu Val Asn Pro Tyr Asn Gly Phe Ser Ser Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Gln Gly Lys Ala Ser Leu Thr Val Asp Arg Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Glu Leu His Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Glu Phe Tyr Gly Tyr Arg Tyr Phe Asp Val Trp 
        115                 120                 125             


Gly Gln Gly Thr Ala Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
    130                 135                 140                 


Ser Val Phe Pro Leu Ala Pro Ser Ser Lys Ser Thr Ser Gly Gly Thr 
145                 150                 155                 160 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
                165                 170                 175     


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
            180                 185                 190         


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
        195                 200                 205             


Val Pro Ser Ser Ser Leu Gly Thr Gln Thr Tyr Ile Cys Asn Val Asn 
    210                 215                 220                 


His Lys Pro Ser Asn Thr Lys Val Asp Lys Lys Val Glu Pro Lys Ser 
225                 230                 235                 240 


Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly 
465         


<210>  19
<211>  510
<212>  PRT
<213>  Homo sapiens

<400>  19

Gln Gly Lys Glu Val Val Leu Leu Asp Phe Ala Ala Ala Gly Gly Glu 
1               5                   10                  15      


Leu Gly Trp Leu Thr His Pro Tyr Gly Lys Gly Trp Asp Leu Met Gln 
            20                  25                  30          


Asn Ile Met Asn Asp Met Pro Ile Tyr Met Tyr Ser Val Cys Asn Val 
        35                  40                  45              


Met Ser Gly Asp Gln Asp Asn Trp Leu Arg Thr Asn Trp Val Tyr Arg 
    50                  55                  60                  


Gly Glu Ala Glu Arg Ile Phe Ile Glu Leu Lys Phe Thr Val Arg Asp 
65                  70                  75                  80  


Cys Asn Ser Phe Pro Gly Gly Ala Ser Ser Cys Lys Glu Thr Phe Asn 
                85                  90                  95      


Leu Tyr Tyr Ala Glu Ser Asp Leu Asp Tyr Gly Thr Asn Phe Gln Lys 
            100                 105                 110         


Arg Leu Phe Thr Lys Ile Asp Thr Ile Ala Pro Asp Glu Ile Thr Val 
        115                 120                 125             


Ser Ser Asp Phe Glu Ala Arg His Val Lys Leu Asn Val Glu Glu Arg 
    130                 135                 140                 


Ser Val Gly Pro Leu Thr Arg Lys Gly Phe Tyr Leu Ala Phe Gln Asp 
145                 150                 155                 160 


Ile Gly Ala Cys Val Ala Leu Leu Ser Val Arg Val Tyr Tyr Lys Lys 
                165                 170                 175     


Cys Pro Glu Leu Leu Gln Gly Leu Ala His Phe Pro Glu Thr Ile Ala 
            180                 185                 190         


Gly Ser Asp Ala Pro Ser Leu Ala Thr Val Ala Gly Thr Cys Val Asp 
        195                 200                 205             


His Ala Val Val Pro Pro Gly Gly Glu Glu Pro Arg Met His Cys Ala 
    210                 215                 220                 


Val Asp Gly Glu Trp Leu Val Pro Ile Gly Gln Cys Leu Cys Gln Ala 
225                 230                 235                 240 


Gly Tyr Glu Lys Val Glu Asp Ala Cys Gln Ala Cys Ser Pro Gly Phe 
                245                 250                 255     


Phe Lys Phe Glu Ala Ser Glu Ser Pro Cys Leu Glu Cys Pro Glu His 
            260                 265                 270         


Thr Leu Pro Ser Pro Glu Gly Ala Thr Ser Cys Glu Cys Glu Glu Gly 
        275                 280                 285             


Phe Phe Arg Ala Pro Gln Asp Pro Ala Ser Met Pro Cys Thr Arg Pro 
    290                 295                 300                 


Pro Ser Ala Pro His Tyr Leu Thr Ala Val Gly Met Gly Ala Lys Val 
305                 310                 315                 320 


Glu Leu Arg Trp Thr Pro Pro Gln Asp Ser Gly Gly Arg Glu Asp Ile 
                325                 330                 335     


Val Tyr Ser Val Thr Cys Glu Gln Cys Trp Pro Glu Ser Gly Glu Cys 
            340                 345                 350         


Gly Pro Cys Glu Ala Ser Val Arg Tyr Ser Glu Pro Pro His Gly Leu 
        355                 360                 365             


Thr Arg Thr Ser Val Thr Val Ser Asp Leu Glu Pro His Met Asn Tyr 
    370                 375                 380                 


Thr Phe Thr Val Glu Ala Arg Asn Gly Val Ser Gly Leu Val Thr Ser 
385                 390                 395                 400 


Arg Ser Phe Arg Thr Ala Ser Val Ser Ile Asn Gln Thr Glu Pro Pro 
                405                 410                 415     


Lys Val Arg Leu Glu Gly Arg Ser Thr Thr Ser Leu Ser Val Ser Trp 
            420                 425                 430         


Ser Ile Pro Pro Pro Gln Gln Ser Arg Val Trp Lys Tyr Glu Val Thr 
        435                 440                 445             


Tyr Arg Lys Lys Gly Asp Ser Asn Ser Tyr Asn Val Arg Arg Thr Glu 
    450                 455                 460                 


Gly Phe Ser Val Thr Leu Asp Asp Leu Ala Pro Asp Thr Thr Tyr Leu 
465                 470                 475                 480 


Val Gln Val Gln Ala Leu Thr Gln Glu Gly Gln Gly Ala Gly Ser Lys 
                485                 490                 495     


Val His Glu Phe Gln Thr Leu Ser Pro Glu Gly Ser Gly Asn 
            500                 505                 510 