                         SEQUENCE LISTING

<110>  Charite - Universittsmedizin Berlin
 
<120>  Neue Marker fr die Diagnose von Zliakie

<130>  P680209DE

<160>  7     

<170>  PatentIn version 3.3

<210>  1
<211>  24
<212>  PRT
<213>  artificial

<220>
<223>  artificial peptide

<400>  1

Pro Phe Pro Gln Pro Glu Gln Pro Phe Gln Pro Glu Gln Pro Phe Gln 
1               5                   10                  15      


Glu Gln Pro Phe Pro Gln Pro Glu 
            20                  


<210>  2
<211>  30
<212>  PRT
<213>  artificial

<220>
<223>  artificial peptide

<400>  2

Gln Glu Gln Pro Phe Pro Gln Pro Glu Gln Pro Phe Gln Pro Glu Gln 
1               5                   10                  15      


Pro Phe Gln Glu Gln Pro Phe Pro Gln Pro Glu Gln Pro Phe 
            20                  25                  30  


<210>  3
<211>  31
<212>  PRT
<213>  artificial

<220>
<223>  artificial peptide

<400>  3

Gln Glu Gln Pro Phe Pro Gln Pro Glu Gln Pro Phe Gln Pro Glu Gln 
1               5                   10                  15      


Pro Phe Gln Glu Gln Pro Phe Pro Gln Pro Glu Gln Pro Phe Lys 
            20                  25                  30      


<210>  4
<211>  31
<212>  PRT
<213>  artificial

<220>
<223>  artificial peptide


<220>
<221>  BINDING
<222>  (31)..(31)
<223>  Lys is biotinylated

<400>  4

Gln Glu Gln Pro Phe Pro Gln Pro Glu Gln Pro Phe Gln Pro Glu Gln 
1               5                   10                  15      


Pro Phe Gln Glu Gln Pro Phe Pro Gln Pro Glu Gln Pro Phe Lys 
            20                  25                  30      


<210>  5
<211>  687
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Ala Glu Glu Leu Val Leu Glu Arg Cys Asp Leu Glu Leu Glu Thr 
1               5                   10                  15      


Asn Gly Arg Asp His His Thr Ala Asp Leu Cys Arg Glu Lys Leu Val 
            20                  25                  30          


Val Arg Arg Gly Gln Pro Phe Trp Leu Thr Leu His Phe Glu Gly Arg 
        35                  40                  45              


Asn Tyr Glu Ala Ser Val Asp Ser Leu Thr Phe Ser Val Val Thr Gly 
    50                  55                  60                  


Pro Ala Pro Ser Gln Glu Ala Gly Thr Lys Ala Arg Phe Pro Leu Arg 
65                  70                  75                  80  


Asp Ala Val Glu Glu Gly Asp Trp Thr Ala Thr Val Val Asp Gln Gln 
                85                  90                  95      


Asp Cys Thr Leu Ser Leu Gln Leu Thr Thr Pro Ala Asn Ala Pro Ile 
            100                 105                 110         


Gly Leu Tyr Arg Leu Ser Leu Glu Ala Ser Thr Gly Tyr Gln Gly Ser 
        115                 120                 125             


Ser Phe Val Leu Gly His Phe Ile Leu Leu Phe Asn Ala Trp Cys Pro 
    130                 135                 140                 


Ala Asp Ala Val Tyr Leu Asp Ser Glu Glu Glu Arg Gln Glu Tyr Val 
145                 150                 155                 160 


Leu Thr Gln Gln Gly Phe Ile Tyr Gln Gly Ser Ala Lys Phe Ile Lys 
                165                 170                 175     


Asn Ile Pro Trp Asn Phe Gly Gln Phe Glu Asp Gly Ile Leu Asp Ile 
            180                 185                 190         


Cys Leu Ile Leu Leu Asp Val Asn Pro Lys Phe Leu Lys Asn Ala Gly 
        195                 200                 205             


Arg Asp Cys Ser Arg Arg Ser Ser Pro Val Tyr Val Gly Arg Val Val 
    210                 215                 220                 


Ser Gly Met Val Asn Cys Asn Asp Asp Gln Gly Val Leu Leu Gly Arg 
225                 230                 235                 240 


Trp Asp Asn Asn Tyr Gly Asp Gly Val Ser Pro Met Ser Trp Ile Gly 
                245                 250                 255     


Ser Val Asp Ile Leu Arg Arg Trp Lys Asn His Gly Cys Gln Arg Val 
            260                 265                 270         


Lys Tyr Gly Gln Cys Trp Val Phe Ala Ala Val Ala Cys Thr Val Leu 
        275                 280                 285             


Arg Cys Leu Gly Ile Pro Thr Arg Val Val Thr Asn Tyr Asn Ser Ala 
    290                 295                 300                 


His Asp Gln Asn Ser Asn Leu Leu Ile Glu Tyr Phe Arg Asn Glu Phe 
305                 310                 315                 320 


Gly Glu Ile Gln Gly Asp Lys Ser Glu Met Ile Trp Asn Phe His Cys 
                325                 330                 335     


Trp Val Glu Ser Trp Met Thr Arg Pro Asp Leu Gln Pro Gly Tyr Glu 
            340                 345                 350         


Gly Trp Gln Ala Leu Asp Pro Thr Pro Gln Glu Lys Ser Glu Gly Thr 
        355                 360                 365             


Tyr Cys Cys Gly Pro Val Pro Val Arg Ala Ile Lys Glu Gly Asp Leu 
    370                 375                 380                 


Ser Thr Lys Tyr Asp Ala Pro Phe Val Phe Ala Glu Val Asn Ala Asp 
385                 390                 395                 400 


Val Val Asp Trp Ile Gln Gln Asp Asp Gly Ser Val His Lys Ser Ile 
                405                 410                 415     


Asn Arg Ser Leu Ile Val Gly Leu Lys Ile Ser Thr Lys Ser Val Gly 
            420                 425                 430         


Arg Asp Glu Arg Glu Asp Ile Thr His Thr Tyr Lys Tyr Pro Glu Gly 
        435                 440                 445             


Ser Ser Glu Glu Arg Glu Ala Phe Thr Arg Ala Asn His Leu Asn Lys 
    450                 455                 460                 


Leu Ala Glu Lys Glu Glu Thr Gly Met Ala Met Arg Ile Arg Val Gly 
465                 470                 475                 480 


Gln Ser Met Asn Met Gly Ser Asp Phe Asp Val Phe Ala His Ile Thr 
                485                 490                 495     


Asn Asn Thr Ala Glu Glu Tyr Val Cys Arg Leu Leu Leu Cys Ala Arg 
            500                 505                 510         


Thr Val Ser Tyr Asn Gly Ile Leu Gly Pro Glu Cys Gly Thr Lys Tyr 
        515                 520                 525             


Leu Leu Asn Leu Asn Leu Glu Pro Phe Ser Glu Lys Ser Val Pro Leu 
    530                 535                 540                 


Cys Ile Leu Tyr Glu Lys Tyr Arg Asp Cys Leu Thr Glu Ser Asn Leu 
545                 550                 555                 560 


Ile Lys Val Arg Ala Leu Leu Val Glu Pro Val Ile Asn Ser Tyr Leu 
                565                 570                 575     


Leu Ala Glu Arg Asp Leu Tyr Leu Glu Asn Pro Glu Ile Lys Ile Arg 
            580                 585                 590         


Ile Leu Gly Glu Pro Lys Gln Lys Arg Lys Leu Val Ala Glu Val Ser 
        595                 600                 605             


Leu Gln Asn Pro Leu Pro Val Ala Leu Glu Gly Cys Thr Phe Thr Val 
    610                 615                 620                 


Glu Gly Ala Gly Leu Thr Glu Glu Gln Lys Thr Val Glu Ile Pro Asp 
625                 630                 635                 640 


Pro Val Glu Ala Gly Glu Glu Val Lys Val Arg Met Asp Leu Leu Pro 
                645                 650                 655     


Leu His Met Gly Leu His Lys Leu Val Val Asn Phe Glu Ser Asp Lys 
            660                 665                 670         


Leu Lys Ala Val Lys Gly Phe Arg Asn Val Ile Ile Gly Pro Ala 
        675                 680                 685         


<210>  6
<211>  717
<212>  PRT
<213>  artificial

<220>
<223>  artificial

<400>  6

Met Ala Glu Glu Leu Val Leu Glu Arg Cys Asp Leu Glu Leu Glu Thr 
1               5                   10                  15      


Asn Gly Arg Asp His His Thr Ala Asp Leu Cys Arg Glu Lys Leu Val 
            20                  25                  30          


Val Arg Arg Gly Gln Pro Phe Trp Leu Thr Leu His Phe Glu Gly Arg 
        35                  40                  45              


Asn Tyr Glu Ala Ser Val Asp Ser Leu Thr Phe Ser Val Val Thr Gly 
    50                  55                  60                  


Pro Ala Pro Ser Gln Glu Ala Gly Thr Lys Ala Arg Phe Pro Leu Arg 
65                  70                  75                  80  


Asp Ala Val Glu Glu Gly Asp Trp Thr Ala Thr Val Val Asp Gln Gln 
                85                  90                  95      


Asp Cys Thr Leu Ser Leu Gln Leu Thr Thr Pro Ala Asn Ala Pro Ile 
            100                 105                 110         


Gly Leu Tyr Arg Leu Ser Leu Glu Ala Ser Thr Gly Tyr Gln Gly Ser 
        115                 120                 125             


Ser Phe Val Leu Gly His Phe Ile Leu Leu Phe Asn Ala Trp Cys Pro 
    130                 135                 140                 


Ala Asp Ala Val Tyr Leu Asp Ser Glu Glu Glu Arg Gln Glu Tyr Val 
145                 150                 155                 160 


Leu Thr Gln Gln Gly Phe Ile Tyr Gln Gly Ser Ala Lys Phe Ile Lys 
                165                 170                 175     


Asn Ile Pro Trp Asn Phe Gly Gln Phe Glu Asp Gly Ile Leu Asp Ile 
            180                 185                 190         


Cys Leu Ile Leu Leu Asp Val Asn Pro Lys Phe Leu Lys Asn Ala Gly 
        195                 200                 205             


Arg Asp Cys Ser Arg Arg Ser Ser Pro Val Tyr Val Gly Arg Val Val 
    210                 215                 220                 


Ser Gly Met Val Asn Cys Asn Asp Asp Gln Gly Val Leu Leu Gly Arg 
225                 230                 235                 240 


Trp Asp Asn Asn Tyr Gly Asp Gly Val Ser Pro Met Ser Trp Ile Gly 
                245                 250                 255     


Ser Val Asp Ile Leu Arg Arg Trp Lys Asn His Gly Cys Gln Arg Val 
            260                 265                 270         


Lys Tyr Gly Gln Cys Trp Val Phe Ala Ala Val Ala Cys Thr Val Leu 
        275                 280                 285             


Arg Cys Leu Gly Ile Pro Thr Arg Val Val Thr Asn Tyr Asn Ser Ala 
    290                 295                 300                 


His Asp Gln Asn Ser Asn Leu Leu Ile Glu Tyr Phe Arg Asn Glu Phe 
305                 310                 315                 320 


Gly Glu Ile Gln Gly Asp Lys Ser Glu Met Ile Trp Asn Phe His Cys 
                325                 330                 335     


Trp Val Glu Ser Trp Met Thr Arg Pro Asp Leu Gln Pro Gly Tyr Glu 
            340                 345                 350         


Gly Trp Gln Ala Leu Asp Pro Thr Pro Gln Glu Lys Ser Glu Gly Thr 
        355                 360                 365             


Tyr Cys Cys Gly Pro Val Pro Val Arg Ala Ile Lys Glu Gly Asp Leu 
    370                 375                 380                 


Ser Thr Lys Tyr Asp Ala Pro Phe Val Phe Ala Glu Val Asn Ala Asp 
385                 390                 395                 400 


Val Val Asp Trp Ile Gln Gln Asp Asp Gly Ser Val His Lys Ser Ile 
                405                 410                 415     


Asn Arg Ser Leu Ile Val Gly Leu Lys Ile Ser Thr Lys Ser Val Gly 
            420                 425                 430         


Arg Asp Glu Arg Glu Asp Ile Thr His Thr Tyr Lys Tyr Pro Glu Gly 
        435                 440                 445             


Ser Ser Glu Glu Arg Glu Ala Phe Thr Arg Ala Asn His Leu Asn Lys 
    450                 455                 460                 


Leu Ala Glu Lys Glu Glu Thr Gly Met Ala Met Arg Ile Arg Val Gly 
465                 470                 475                 480 


Gln Ser Met Asn Met Gly Ser Asp Phe Asp Val Phe Ala His Ile Thr 
                485                 490                 495     


Asn Asn Thr Ala Glu Glu Tyr Val Cys Arg Leu Leu Leu Cys Ala Arg 
            500                 505                 510         


Thr Val Ser Tyr Asn Gly Ile Leu Gly Pro Glu Cys Gly Thr Lys Tyr 
        515                 520                 525             


Leu Leu Asn Leu Asn Leu Glu Pro Phe Ser Glu Lys Ser Val Pro Leu 
    530                 535                 540                 


Cys Ile Leu Tyr Glu Lys Tyr Arg Asp Cys Leu Thr Glu Ser Asn Leu 
545                 550                 555                 560 


Ile Lys Val Arg Ala Leu Leu Val Glu Pro Val Ile Asn Ser Tyr Leu 
                565                 570                 575     


Leu Ala Glu Arg Asp Leu Tyr Leu Glu Asn Pro Glu Ile Lys Ile Arg 
            580                 585                 590         


Ile Leu Gly Glu Pro Lys Gln Lys Arg Lys Leu Val Ala Glu Val Ser 
        595                 600                 605             


Leu Gln Asn Pro Leu Pro Val Ala Leu Glu Gly Cys Thr Phe Thr Val 
    610                 615                 620                 


Glu Gly Ala Gly Leu Thr Glu Glu Gln Lys Thr Val Glu Ile Pro Asp 
625                 630                 635                 640 


Pro Val Glu Ala Gly Glu Glu Val Lys Val Arg Met Asp Leu Leu Pro 
                645                 650                 655     


Leu His Met Gly Leu His Lys Leu Val Val Asn Phe Glu Ser Asp Lys 
            660                 665                 670         


Leu Lys Ala Val Lys Gly Phe Arg Asn Val Ile Ile Gly Pro Ala Gln 
        675                 680                 685             


Glu Gln Pro Phe Pro Gln Pro Glu Gln Pro Phe Gln Pro Glu Gln Pro 
    690                 695                 700                 


Phe Gln Glu Gln Pro Phe Pro Gln Pro Glu Gln Pro Phe 
705                 710                 715         


<210>  7
<211>  747
<212>  PRT
<213>  artificial

<220>
<223>  artificial

<400>  7

Met Ala Glu Glu Leu Val Leu Glu Arg Cys Asp Leu Glu Leu Glu Thr 
1               5                   10                  15      


Asn Gly Arg Asp His His Thr Ala Asp Leu Cys Arg Glu Lys Leu Val 
            20                  25                  30          


Val Arg Arg Gly Gln Pro Phe Trp Leu Thr Leu His Phe Glu Gly Arg 
        35                  40                  45              


Asn Tyr Glu Ala Ser Val Asp Ser Leu Thr Phe Ser Val Val Thr Gly 
    50                  55                  60                  


Pro Ala Pro Ser Gln Glu Ala Gly Thr Lys Ala Arg Phe Pro Leu Arg 
65                  70                  75                  80  


Asp Ala Val Glu Glu Gly Asp Trp Thr Ala Thr Val Val Asp Gln Gln 
                85                  90                  95      


Asp Cys Thr Leu Ser Leu Gln Leu Thr Thr Pro Ala Asn Ala Pro Ile 
            100                 105                 110         


Gly Leu Tyr Arg Leu Ser Leu Glu Ala Ser Thr Gly Tyr Gln Gly Ser 
        115                 120                 125             


Ser Phe Val Leu Gly His Phe Ile Leu Leu Phe Asn Ala Trp Cys Pro 
    130                 135                 140                 


Ala Asp Ala Val Tyr Leu Asp Ser Glu Glu Glu Arg Gln Glu Tyr Val 
145                 150                 155                 160 


Leu Thr Gln Gln Gly Phe Ile Tyr Gln Gly Ser Ala Lys Phe Ile Lys 
                165                 170                 175     


Asn Ile Pro Trp Asn Phe Gly Gln Phe Glu Asp Gly Ile Leu Asp Ile 
            180                 185                 190         


Cys Leu Ile Leu Leu Asp Val Asn Pro Lys Phe Leu Lys Asn Ala Gly 
        195                 200                 205             


Arg Asp Cys Ser Arg Arg Ser Ser Pro Val Tyr Val Gly Arg Val Val 
    210                 215                 220                 


Ser Gly Met Val Asn Cys Asn Asp Asp Gln Gly Val Leu Leu Gly Arg 
225                 230                 235                 240 


Trp Asp Asn Asn Tyr Gly Asp Gly Val Ser Pro Met Ser Trp Ile Gly 
                245                 250                 255     


Ser Val Asp Ile Leu Arg Arg Trp Lys Asn His Gly Cys Gln Arg Val 
            260                 265                 270         


Lys Tyr Gly Gln Cys Trp Val Phe Ala Ala Val Ala Cys Thr Val Leu 
        275                 280                 285             


Arg Cys Leu Gly Ile Pro Thr Arg Val Val Thr Asn Tyr Asn Ser Ala 
    290                 295                 300                 


His Asp Gln Asn Ser Asn Leu Leu Ile Glu Tyr Phe Arg Asn Glu Phe 
305                 310                 315                 320 


Gly Glu Ile Gln Gly Asp Lys Ser Glu Met Ile Trp Asn Phe His Cys 
                325                 330                 335     


Trp Val Glu Ser Trp Met Thr Arg Pro Asp Leu Gln Pro Gly Tyr Glu 
            340                 345                 350         


Gly Trp Gln Ala Leu Asp Pro Thr Pro Gln Glu Lys Ser Glu Gly Thr 
        355                 360                 365             


Tyr Cys Cys Gly Pro Val Pro Val Arg Ala Ile Lys Glu Gly Asp Leu 
    370                 375                 380                 


Ser Thr Lys Tyr Asp Ala Pro Phe Val Phe Ala Glu Val Asn Ala Asp 
385                 390                 395                 400 


Val Val Asp Trp Ile Gln Gln Asp Asp Gly Ser Val His Lys Ser Ile 
                405                 410                 415     


Asn Arg Ser Leu Ile Val Gly Leu Lys Ile Ser Thr Lys Ser Val Gly 
            420                 425                 430         


Arg Asp Glu Arg Glu Asp Ile Thr His Thr Tyr Lys Tyr Pro Glu Gly 
        435                 440                 445             


Ser Ser Glu Glu Arg Glu Ala Phe Thr Arg Ala Asn His Leu Asn Lys 
    450                 455                 460                 


Leu Ala Glu Lys Glu Glu Thr Gly Met Ala Met Arg Ile Arg Val Gly 
465                 470                 475                 480 


Gln Ser Met Asn Met Gly Ser Asp Phe Asp Val Phe Ala His Ile Thr 
                485                 490                 495     


Asn Asn Thr Ala Glu Glu Tyr Val Cys Arg Leu Leu Leu Cys Ala Arg 
            500                 505                 510         


Thr Val Ser Tyr Asn Gly Ile Leu Gly Pro Glu Cys Gly Thr Lys Tyr 
        515                 520                 525             


Leu Leu Asn Leu Asn Leu Glu Pro Phe Ser Glu Lys Ser Val Pro Leu 
    530                 535                 540                 


Cys Ile Leu Tyr Glu Lys Tyr Arg Asp Cys Leu Thr Glu Ser Asn Leu 
545                 550                 555                 560 


Ile Lys Val Arg Ala Leu Leu Val Glu Pro Val Ile Asn Ser Tyr Leu 
                565                 570                 575     


Leu Ala Glu Arg Asp Leu Tyr Leu Glu Asn Pro Glu Ile Lys Ile Arg 
            580                 585                 590         


Ile Leu Gly Glu Pro Lys Gln Lys Arg Lys Leu Val Ala Glu Val Ser 
        595                 600                 605             


Leu Gln Asn Pro Leu Pro Val Ala Leu Glu Gly Cys Thr Phe Thr Val 
    610                 615                 620                 


Glu Gly Ala Gly Leu Thr Glu Glu Gln Lys Thr Val Glu Ile Pro Asp 
625                 630                 635                 640 


Pro Val Glu Ala Gly Glu Glu Val Lys Val Arg Met Asp Leu Leu Pro 
                645                 650                 655     


Leu His Met Gly Leu His Lys Leu Val Val Asn Phe Glu Ser Asp Lys 
            660                 665                 670         


Leu Lys Ala Val Lys Gly Phe Arg Asn Val Ile Ile Gly Pro Ala Gln 
        675                 680                 685             


Glu Gln Pro Phe Pro Gln Pro Glu Gln Pro Phe Gln Pro Glu Gln Pro 
    690                 695                 700                 


Phe Gln Glu Gln Pro Phe Pro Gln Pro Glu Gln Pro Phe Gln Glu Gln 
705                 710                 715                 720 


Pro Phe Pro Gln Pro Glu Gln Pro Phe Gln Pro Glu Gln Pro Phe Gln 
                725                 730                 735     


Glu Gln Pro Phe Pro Gln Pro Glu Gln Pro Phe 
            740                 745         


