                         SEQUENCE LISTING

<110>  CNRS
 
<120>  Procd d'imagerie cellulaire pour la visualisation de la 
       biogense des microARNs dans les cellules

<130>  BFF090384

<160>  58    

<170>  PatentIn version 3.3

<210>  1
<211>  773
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Glu Thr Asp Glu Ser Pro Ser Pro Leu Pro Cys Gly Pro Ala Gly 
1               5                   10                  15      


Glu Ala Val Met Glu Ser Arg Ala Arg Pro Phe Gln Ala Leu Pro Arg 
            20                  25                  30          


Glu Gln Ser Pro Pro Pro Pro Leu Gln Thr Ser Ser Gly Ala Glu Val 
        35                  40                  45              


Met Asp Val Gly Ser Gly Gly Asp Gly Gln Ser Glu Leu Pro Ala Glu 
    50                  55                  60                  


Asp Pro Phe Asn Phe Tyr Gly Ala Ser Leu Leu Ser Lys Gly Ser Phe 
65                  70                  75                  80  


Ser Lys Gly Arg Leu Leu Ile Asp Pro Asn Cys Ser Gly His Ser Pro 
                85                  90                  95      


Arg Thr Ala Arg His Ala Pro Ala Val Arg Lys Phe Ser Pro Asp Leu 
            100                 105                 110         


Lys Leu Leu Lys Asp Val Lys Ile Ser Val Ser Phe Thr Glu Ser Cys 
        115                 120                 125             


Arg Ser Lys Asp Arg Lys Val Leu Tyr Thr Gly Ala Glu Arg Asp Val 
    130                 135                 140                 


Arg Ala Glu Cys Gly Leu Leu Leu Ser Pro Val Ser Gly Asp Val His 
145                 150                 155                 160 


Ala Cys Pro Phe Gly Gly Ser Val Gly Asp Gly Val Gly Ile Gly Gly 
                165                 170                 175     


Glu Ser Ala Asp Lys Lys Asp Glu Glu Asn Glu Leu Asp Gln Glu Lys 
            180                 185                 190         


Arg Val Glu Tyr Ala Val Leu Asp Glu Leu Glu Asp Phe Thr Asp Asn 
        195                 200                 205             


Leu Glu Leu Asp Glu Glu Gly Ala Gly Gly Phe Thr Ala Lys Ala Ile 
    210                 215                 220                 


Val Gln Arg Asp Arg Val Asp Glu Glu Ala Leu Asn Phe Pro Tyr Glu 
225                 230                 235                 240 


Asp Asp Phe Asp Asn Asp Val Asp Ala Leu Leu Glu Glu Gly Leu Cys 
                245                 250                 255     


Ala Pro Lys Lys Arg Arg Thr Glu Glu Lys Tyr Gly Gly Asp Ser Asp 
            260                 265                 270         


His Pro Ser Asp Gly Glu Thr Ser Val Gln Pro Met Met Thr Lys Ile 
        275                 280                 285             


Lys Thr Val Leu Lys Ser Arg Gly Arg Pro Pro Thr Glu Pro Leu Pro 
    290                 295                 300                 


Asp Gly Trp Ile Met Thr Phe His Asn Ser Gly Val Pro Val Tyr Leu 
305                 310                 315                 320 


His Arg Glu Ser Arg Val Val Thr Trp Ser Arg Pro Tyr Phe Leu Gly 
                325                 330                 335     


Thr Gly Ser Ile Arg Lys His Asp Pro Pro Leu Ser Ser Ile Pro Cys 
            340                 345                 350         


Leu His Tyr Lys Lys Met Lys Asp Asn Glu Glu Arg Glu Gln Ser Ser 
        355                 360                 365             


Asp Leu Thr Pro Ser Gly Asp Val Ser Pro Val Lys Pro Leu Ser Arg 
    370                 375                 380                 


Ser Ala Glu Leu Glu Phe Pro Leu Asp Glu Pro Asp Ser Met Gly Ala 
385                 390                 395                 400 


Asp Pro Gly Pro Pro Asp Glu Lys Asp Pro Leu Gly Ala Glu Ala Ala 
                405                 410                 415     


Pro Gly Ala Leu Gly Gln Val Lys Ala Lys Val Glu Val Cys Lys Asp 
            420                 425                 430         


Glu Ser Val Asp Leu Glu Glu Phe Arg Ser Tyr Leu Glu Lys Arg Phe 
        435                 440                 445             


Asp Phe Glu Gln Val Thr Val Lys Lys Phe Arg Thr Trp Ala Glu Arg 
    450                 455                 460                 


Arg Gln Phe Asn Arg Glu Met Lys Arg Lys Gln Ala Glu Ser Glu Arg 
465                 470                 475                 480 


Pro Ile Leu Pro Ala Asn Gln Lys Leu Ile Thr Leu Ser Val Gln Asp 
                485                 490                 495     


Ala Pro Thr Lys Lys Glu Phe Val Ile Asn Pro Asn Gly Lys Ser Glu 
            500                 505                 510         


Val Cys Ile Leu His Glu Tyr Met Gln Arg Val Leu Lys Val Arg Pro 
        515                 520                 525             


Val Tyr Asn Phe Phe Glu Cys Glu Asn Pro Ser Glu Pro Phe Gly Ala 
    530                 535                 540                 


Ser Val Thr Ile Asp Gly Val Thr Tyr Gly Ser Gly Thr Ala Ser Ser 
545                 550                 555                 560 


Lys Lys Leu Ala Lys Asn Lys Ala Ala Arg Ala Thr Leu Glu Ile Leu 
                565                 570                 575     


Ile Pro Asp Phe Val Lys Gln Thr Ser Glu Glu Lys Pro Lys Asp Ser 
            580                 585                 590         


Glu Glu Leu Glu Tyr Phe Asn His Ile Ser Ile Glu Asp Ser Arg Val 
        595                 600                 605             


Tyr Glu Leu Thr Ser Lys Ala Gly Leu Leu Ser Pro Tyr Gln Ile Leu 
    610                 615                 620                 


His Glu Cys Leu Lys Arg Asn His Gly Met Gly Asp Thr Ser Ile Lys 
625                 630                 635                 640 


Phe Glu Val Val Pro Gly Lys Asn Gln Lys Ser Glu Tyr Val Met Ala 
                645                 650                 655     


Cys Gly Lys His Thr Val Arg Gly Trp Cys Lys Asn Lys Arg Val Gly 
            660                 665                 670         


Lys Gln Leu Ala Ser Gln Lys Ile Leu Gln Leu Leu His Pro His Val 
        675                 680                 685             


Lys Asn Trp Gly Ser Leu Leu Arg Met Tyr Gly Arg Glu Ser Ser Lys 
    690                 695                 700                 


Met Val Lys Gln Glu Thr Ser Asp Lys Ser Val Ile Glu Leu Gln Gln 
705                 710                 715                 720 


Tyr Ala Lys Lys Asn Lys Pro Asn Leu His Ile Leu Ser Lys Leu Gln 
                725                 730                 735     


Glu Glu Met Lys Arg Leu Ala Glu Glu Arg Glu Glu Thr Arg Lys Lys 
            740                 745                 750         


Pro Lys Met Ser Ile Val Ala Ser Ala Gln Pro Gly Gly Glu Pro Leu 
        755                 760                 765             


Cys Thr Val Asp Val 
    770             


<210>  2
<211>  490
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Met Thr Lys Ile Lys Thr Val Leu Lys Ser Arg Gly Arg Pro Pro 
1               5                   10                  15      


Thr Glu Pro Leu Pro Asp Gly Trp Ile Met Thr Phe His Asn Ser Gly 
            20                  25                  30          


Val Pro Val Tyr Leu His Arg Glu Ser Arg Val Val Thr Trp Ser Arg 
        35                  40                  45              


Pro Tyr Phe Leu Gly Thr Gly Ser Ile Arg Lys His Asp Pro Pro Leu 
    50                  55                  60                  


Ser Ser Ile Pro Cys Leu His Tyr Lys Lys Met Lys Asp Asn Glu Glu 
65                  70                  75                  80  


Arg Glu Gln Ser Ser Asp Leu Thr Pro Ser Gly Asp Val Ser Pro Val 
                85                  90                  95      


Lys Pro Leu Ser Arg Ser Ala Glu Leu Glu Phe Pro Leu Asp Glu Pro 
            100                 105                 110         


Asp Ser Met Gly Ala Asp Pro Gly Pro Pro Asp Glu Lys Asp Pro Leu 
        115                 120                 125             


Gly Ala Glu Ala Ala Pro Gly Ala Leu Gly Gln Val Lys Ala Lys Val 
    130                 135                 140                 


Glu Val Cys Lys Asp Glu Ser Val Asp Leu Glu Glu Phe Arg Ser Tyr 
145                 150                 155                 160 


Leu Glu Lys Arg Phe Asp Phe Glu Gln Val Thr Val Lys Lys Phe Arg 
                165                 170                 175     


Thr Trp Ala Glu Arg Arg Gln Phe Asn Arg Glu Met Lys Arg Lys Gln 
            180                 185                 190         


Ala Glu Ser Glu Arg Pro Ile Leu Pro Ala Asn Gln Lys Leu Ile Thr 
        195                 200                 205             


Leu Ser Val Gln Asp Ala Pro Thr Lys Lys Glu Phe Val Ile Asn Pro 
    210                 215                 220                 


Asn Gly Lys Ser Glu Val Cys Ile Leu His Glu Tyr Met Gln Arg Val 
225                 230                 235                 240 


Leu Lys Val Arg Pro Val Tyr Asn Phe Phe Glu Cys Glu Asn Pro Ser 
                245                 250                 255     


Glu Pro Phe Gly Ala Ser Val Thr Ile Asp Gly Val Thr Tyr Gly Ser 
            260                 265                 270         


Gly Thr Ala Ser Ser Lys Lys Leu Ala Lys Asn Lys Ala Ala Arg Ala 
        275                 280                 285             


Thr Leu Glu Ile Leu Ile Pro Asp Phe Val Lys Gln Thr Ser Glu Glu 
    290                 295                 300                 


Lys Pro Lys Asp Ser Glu Glu Leu Glu Tyr Phe Asn His Ile Ser Ile 
305                 310                 315                 320 


Glu Asp Ser Arg Val Tyr Glu Leu Thr Ser Lys Ala Gly Leu Leu Ser 
                325                 330                 335     


Pro Tyr Gln Ile Leu His Glu Cys Leu Lys Arg Asn His Gly Met Gly 
            340                 345                 350         


Asp Thr Ser Ile Lys Phe Glu Val Val Pro Gly Lys Asn Gln Lys Ser 
        355                 360                 365             


Glu Tyr Val Met Ala Cys Gly Lys His Thr Val Arg Gly Trp Cys Lys 
    370                 375                 380                 


Asn Lys Arg Val Gly Lys Gln Leu Ala Ser Gln Lys Ile Leu Gln Leu 
385                 390                 395                 400 


Leu His Pro His Val Lys Asn Trp Gly Ser Leu Leu Arg Met Tyr Gly 
                405                 410                 415     


Arg Glu Ser Ser Lys Met Val Lys Gln Glu Thr Ser Asp Lys Ser Val 
            420                 425                 430         


Ile Glu Leu Gln Gln Tyr Ala Lys Lys Asn Lys Pro Asn Leu His Ile 
        435                 440                 445             


Leu Ser Lys Leu Gln Glu Glu Met Lys Arg Leu Ala Glu Glu Arg Glu 
    450                 455                 460                 


Glu Thr Arg Lys Lys Pro Lys Met Ser Ile Val Ala Ser Ala Gln Pro 
465                 470                 475                 480 


Gly Gly Glu Pro Leu Cys Thr Val Asp Val 
                485                 490 


<210>  3
<211>  247
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Glu Thr Asp Glu Ser Pro Ser Pro Leu Pro Cys Gly Pro Ala Gly 
1               5                   10                  15      


Glu Ala Val Met Glu Ser Arg Ala Arg Pro Phe Gln Ala Leu Pro Arg 
            20                  25                  30          


Glu Gln Ser Pro Pro Pro Pro Leu Gln Thr Ser Ser Gly Ala Glu Val 
        35                  40                  45              


Met Asp Val Gly Ser Gly Gly Asp Gly Gln Ser Glu Leu Pro Ala Glu 
    50                  55                  60                  


Asp Pro Phe Asn Phe Tyr Gly Ala Ser Leu Leu Ser Lys Gly Ser Phe 
65                  70                  75                  80  


Ser Lys Gly Arg Leu Leu Ile Asp Pro Asn Cys Ser Gly His Ser Pro 
                85                  90                  95      


Arg Thr Ala Arg His Ala Pro Ala Val Arg Lys Phe Ser Pro Asp Leu 
            100                 105                 110         


Lys Leu Leu Lys Asp Val Lys Ile Ser Val Ser Phe Thr Glu Ser Cys 
        115                 120                 125             


Arg Ser Lys Asp Arg Lys Val Leu Tyr Thr Gly Ala Glu Arg Asp Val 
    130                 135                 140                 


Arg Ala Glu Cys Gly Leu Leu Leu Ser Pro Val Ser Gly Asp Val His 
145                 150                 155                 160 


Ala Cys Pro Phe Gly Gly Ser Val Gly Asp Gly Val Gly Ile Gly Gly 
                165                 170                 175     


Glu Ser Ala Asp Lys Lys Asp Glu Glu Asn Glu Leu Asp Gln Glu Lys 
            180                 185                 190         


Arg Val Glu Tyr Ala Val Leu Asp Glu Leu Glu Asp Phe Thr Asp Asn 
        195                 200                 205             


Leu Glu Leu Asp Glu Glu Gly Ala Gly Gly Phe Thr Ala Lys Ala Ile 
    210                 215                 220                 


Val Gln Arg Asp Arg Val Asp Glu Glu Ala Leu Asn Phe Pro Tyr Glu 
225                 230                 235                 240 


Val Cys Trp Gln Pro Leu Leu 
                245         


<210>  4
<211>  773
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Glu Thr Tyr Glu Ser Pro Ser Pro Leu Pro Arg Glu Pro Ala Gly 
1               5                   10                  15      


Glu Ala Met Met Glu Asn Arg Ala Cys Pro Phe Gln Val Leu Pro His 
            20                  25                  30          


Glu Gln Ser Pro Pro Pro Pro Leu Gln Thr Ser Ser Asp Ala Glu Val 
        35                  40                  45              


Met Asp Val Gly Ser Gly Gly Asp Gly Gln Ser Glu Pro Pro Ala Asp 
    50                  55                  60                  


Asp Pro Phe Asn Phe Tyr Gly Ala Ser Leu Leu Ser Lys Gly Ser Phe 
65                  70                  75                  80  


Ser Lys Gly Arg Leu Leu Ile Asp Pro Asn Cys Ser Gly His Ser Pro 
                85                  90                  95      


Arg Thr Ala Arg His Ala Pro Ala Val Arg Lys Phe Ser Pro Asp Leu 
            100                 105                 110         


Lys Leu Leu Lys Asp Val Lys Ile Ser Val Ser Phe Thr Glu Ser Cys 
        115                 120                 125             


Arg Ser Lys Asp Arg Lys Val Leu Tyr Thr Gly Val Glu Arg Ser Thr 
    130                 135                 140                 


Arg Pro Glu Cys Gly Gln Leu Leu Ser Pro Val Ser Gly Asp Val His 
145                 150                 155                 160 


Ala Cys Pro Phe Gly Gly Ser Val Gly Asn Gly Val Gly Leu Gly Gly 
                165                 170                 175     


Glu Ser Ala Asp Lys Lys Asp Glu Glu Asn Glu Leu Asp Gln Glu Lys 
            180                 185                 190         


Arg Val Glu Tyr Ala Val Leu Asp Glu Leu Glu Asp Phe Thr Asp Asn 
        195                 200                 205             


Leu Glu Leu Asp Glu Glu Gly Thr Gly Gly Phe Thr Ala Lys Ala Ile 
    210                 215                 220                 


Val Gln Arg Asp Arg Val Asp Glu Glu Ala Leu Asn Phe Ser Tyr Glu 
225                 230                 235                 240 


Asp Asp Phe Asp Asn Asp Val Asp Ala Leu Leu Glu Glu Gly Leu Cys 
                245                 250                 255     


Ala Pro Lys Lys Arg Arg Met Glu Glu Lys Tyr Gly Gly Asp Ser Asp 
            260                 265                 270         


His Pro Ser Asp Gly Glu Thr Ser Val Gln Pro Met Met Thr Lys Ile 
        275                 280                 285             


Lys Thr Val Leu Lys Ser Arg Gly Arg Pro Pro Thr Glu Pro Leu Pro 
    290                 295                 300                 


Asp Gly Trp Ile Met Thr Phe His Asn Ser Gly Val Pro Val Tyr Leu 
305                 310                 315                 320 


His Arg Glu Ser Arg Val Val Thr Trp Ser Arg Pro Tyr Phe Leu Gly 
                325                 330                 335     


Thr Gly Ser Ile Arg Lys His Asp Pro Pro Leu Ser Ser Ile Pro Cys 
            340                 345                 350         


Leu His Tyr Lys Lys Met Lys Asp Asn Glu Glu Arg Glu Gln Asn Cys 
        355                 360                 365             


Asp Leu Ala Pro Ser Gly Glu Val Ser Pro Val Lys Pro Leu Gly Arg 
    370                 375                 380                 


Ser Ala Glu Leu Asp Phe Pro Leu Glu Glu Pro Asp Ser Met Gly Gly 
385                 390                 395                 400 


Asp Ser Gly Ser Met Asp Glu Lys Asp Pro Leu Gly Ala Glu Ala Ala 
                405                 410                 415     


Ala Gly Ala Leu Gly Gln Val Lys Ala Lys Val Glu Val Cys Lys Asp 
            420                 425                 430         


Glu Ser Val Asp Leu Glu Glu Phe Arg Asn Tyr Leu Glu Lys Arg Phe 
        435                 440                 445             


Asp Phe Glu Gln Val Thr Val Lys Lys Phe Arg Thr Trp Ala Glu Arg 
    450                 455                 460                 


Arg Gln Phe Asn Arg Glu Met Lys Arg Lys Gln Ala Glu Ser Glu Arg 
465                 470                 475                 480 


Pro Ile Leu Pro Ala Asn Gln Lys Leu Ile Thr Leu Ser Val Gln Asp 
                485                 490                 495     


Ala Pro Thr Lys Lys Glu Phe Val Ile Asn Pro Asn Gly Lys Ser Glu 
            500                 505                 510         


Val Cys Ile Leu His Glu Tyr Met Gln Arg Val Leu Lys Val Arg Pro 
        515                 520                 525             


Val Tyr Asn Phe Phe Glu Cys Glu Asn Pro Ser Glu Pro Phe Gly Ala 
    530                 535                 540                 


Ser Val Thr Ile Asp Gly Val Thr Tyr Gly Ser Gly Thr Ala Ser Ser 
545                 550                 555                 560 


Lys Lys Leu Ala Lys Asn Lys Ala Ala Arg Ala Thr Leu Glu Ile Leu 
                565                 570                 575     


Ile Pro Asp Phe Val Lys Gln Thr Ser Glu Glu Lys Pro Lys Asp Ser 
            580                 585                 590         


Glu Glu Leu Glu Tyr Phe Asn His Ile Ser Ile Glu Asp Ser Arg Val 
        595                 600                 605             


Tyr Glu Leu Thr Ser Lys Ala Gly Leu Leu Ser Pro Tyr Gln Ile Leu 
    610                 615                 620                 


His Glu Cys Leu Lys Arg Asn His Gly Met Gly Asp Thr Ser Ile Lys 
625                 630                 635                 640 


Phe Glu Val Val Pro Gly Lys Asn Gln Lys Ser Glu Tyr Val Met Ala 
                645                 650                 655     


Cys Gly Lys His Thr Val Arg Gly Trp Cys Lys Asn Lys Arg Val Gly 
            660                 665                 670         


Lys Gln Leu Ala Ser Gln Lys Ile Leu Gln Leu Leu His Pro His Val 
        675                 680                 685             


Lys Asn Trp Gly Ser Leu Leu Arg Met Tyr Gly Arg Glu Ser Ser Lys 
    690                 695                 700                 


Met Val Lys Gln Glu Thr Ser Asp Lys Ser Val Ile Glu Leu Gln Gln 
705                 710                 715                 720 


Tyr Ala Lys Lys Asn Arg Pro Asn Leu His Ile Leu Ser Lys Leu Gln 
                725                 730                 735     


Glu Glu Met Lys Arg Leu Ala Ala Glu Arg Glu Glu Thr Arg Lys Lys 
            740                 745                 750         


Pro Lys Met Ser Ile Val Ala Ser Ala Gln Pro Gly Gly Glu Pro Leu 
        755                 760                 765             


Cys Thr Val Asp Val 
    770             


<210>  5
<211>  773
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Glu Thr Tyr Glu Ser Pro Ser Pro Leu Pro Arg Glu Pro Ala Gly 
1               5                   10                  15      


Glu Ala Met Met Glu Asn Arg Ala Cys Pro Phe Gln Val Leu Pro His 
            20                  25                  30          


Glu Gln Ser Pro Pro Pro Pro Leu Gln Thr Ser Ser Asp Ala Glu Val 
        35                  40                  45              


Met Asp Val Gly Ser Gly Gly Asp Gly Gln Ser Glu Pro Pro Ala Asp 
    50                  55                  60                  


Asp Pro Phe Asn Phe Tyr Gly Ala Ser Leu Leu Ser Lys Gly Ser Phe 
65                  70                  75                  80  


Ser Lys Gly Arg Leu Leu Ile Asp Pro Asn Cys Ser Gly His Ser Pro 
                85                  90                  95      


Arg Thr Ala Arg His Ala Pro Ala Val Arg Lys Phe Ser Pro Asp Leu 
            100                 105                 110         


Lys Leu Leu Lys Asp Val Lys Ile Ser Val Ser Phe Thr Glu Ser Cys 
        115                 120                 125             


Arg Ser Lys Asp Arg Lys Val Leu Tyr Thr Gly Val Glu Arg Ser Thr 
    130                 135                 140                 


Arg Pro Glu Cys Gly Gln Leu Leu Ser Pro Val Ser Gly Asp Val His 
145                 150                 155                 160 


Ala Cys Pro Phe Gly Gly Ser Val Gly Asn Gly Val Gly Leu Gly Gly 
                165                 170                 175     


Glu Ser Ala Asp Lys Lys Asp Glu Glu Asn Glu Leu Asp Gln Glu Lys 
            180                 185                 190         


Arg Val Glu Tyr Ala Val Leu Asp Glu Leu Glu Asp Phe Thr Asp Asn 
        195                 200                 205             


Leu Glu Leu Asp Glu Glu Gly Thr Gly Gly Phe Thr Ala Lys Ala Ile 
    210                 215                 220                 


Val Gln Arg Asp Arg Val Asp Glu Glu Ala Leu Asn Phe Ser Tyr Glu 
225                 230                 235                 240 


Asp Asp Phe Asp Asn Asp Val Asp Ala Leu Leu Glu Glu Gly Leu Cys 
                245                 250                 255     


Ala Pro Lys Lys Arg Arg Met Glu Glu Lys Tyr Gly Gly Asp Ser Asp 
            260                 265                 270         


His Pro Ser Asp Gly Glu Thr Ser Val Gln Pro Met Met Thr Lys Ile 
        275                 280                 285             


Lys Thr Val Leu Lys Ser Arg Gly Arg Pro Pro Thr Glu Pro Leu Pro 
    290                 295                 300                 


Asp Gly Trp Ile Met Thr Phe His Asn Ser Gly Val Pro Val Tyr Leu 
305                 310                 315                 320 


His Arg Glu Ser Arg Val Val Thr Trp Ser Arg Pro Tyr Phe Leu Gly 
                325                 330                 335     


Thr Gly Ser Ile Arg Lys His Asp Pro Pro Leu Ser Ser Ile Pro Cys 
            340                 345                 350         


Leu His Tyr Lys Lys Met Lys Asp Asn Glu Glu Arg Glu Gln Asn Cys 
        355                 360                 365             


Asp Leu Ala Pro Ser Gly Glu Val Ser Pro Val Lys Pro Leu Gly Arg 
    370                 375                 380                 


Ser Ala Glu Leu Asp Phe Pro Leu Glu Glu Pro Asp Ser Met Gly Gly 
385                 390                 395                 400 


Asp Ser Gly Ser Met Asp Glu Lys Asp Pro Leu Gly Ala Glu Ala Ala 
                405                 410                 415     


Ala Gly Ala Leu Gly Gln Val Lys Ala Lys Val Glu Val Cys Lys Asp 
            420                 425                 430         


Glu Ser Val Asp Leu Glu Glu Phe Arg Asn Tyr Leu Glu Lys Arg Phe 
        435                 440                 445             


Asp Phe Glu Gln Val Thr Val Lys Lys Phe Arg Thr Trp Ala Glu Arg 
    450                 455                 460                 


Arg Gln Phe Asn Arg Glu Met Lys Arg Lys Gln Ala Glu Ser Glu Arg 
465                 470                 475                 480 


Pro Ile Leu Pro Ala Asn Gln Lys Leu Ile Thr Leu Ser Val Gln Asp 
                485                 490                 495     


Ala Pro Thr Lys Lys Glu Phe Val Ile Asn Pro Asn Gly Lys Ser Glu 
            500                 505                 510         


Val Cys Ile Leu His Glu Tyr Met Gln Arg Val Leu Lys Val Arg Pro 
        515                 520                 525             


Val Tyr Asn Phe Phe Glu Cys Glu Asn Pro Ser Glu Pro Phe Gly Ala 
    530                 535                 540                 


Ser Val Thr Ile Asp Gly Val Thr Tyr Gly Ser Gly Thr Ala Ser Ser 
545                 550                 555                 560 


Lys Lys Leu Ala Lys Asn Lys Ala Ala Arg Ala Thr Leu Glu Ile Leu 
                565                 570                 575     


Ile Pro Asp Phe Val Lys Gln Thr Ser Glu Glu Lys Pro Lys Asp Ser 
            580                 585                 590         


Glu Glu Leu Glu Tyr Phe Asn His Ile Ser Ile Glu Asp Ser Arg Val 
        595                 600                 605             


Tyr Glu Leu Thr Ser Lys Ala Gly Leu Leu Ser Pro Tyr Gln Ile Leu 
    610                 615                 620                 


His Glu Cys Leu Lys Arg Asn His Gly Met Gly Asp Thr Ser Ile Lys 
625                 630                 635                 640 


Phe Glu Val Val Pro Gly Lys Asn Gln Lys Ser Glu Tyr Val Met Ala 
                645                 650                 655     


Cys Gly Lys His Thr Val Arg Gly Trp Cys Lys Asn Lys Arg Val Gly 
            660                 665                 670         


Lys Gln Leu Ala Ser Gln Lys Ile Leu Gln Leu Leu His Pro His Val 
        675                 680                 685             


Lys Asn Trp Gly Ser Leu Leu Arg Met Tyr Gly Arg Glu Ser Ser Lys 
    690                 695                 700                 


Met Val Lys Gln Glu Thr Ser Asp Lys Ser Val Ile Glu Leu Gln Gln 
705                 710                 715                 720 


Tyr Ala Lys Lys Asn Arg Pro Asn Leu His Ile Leu Ser Lys Leu Gln 
                725                 730                 735     


Glu Glu Met Lys Arg Leu Ala Ala Glu Arg Glu Glu Thr Arg Lys Lys 
            740                 745                 750         


Pro Lys Met Ser Ile Val Ala Ser Ala Gln Pro Gly Gly Glu Pro Leu 
        755                 760                 765             


Cys Thr Val Asp Val 
    770             


<210>  6
<211>  773
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Glu Thr Tyr Glu Ser Pro Ser Pro Leu Pro Arg Glu Pro Ala Gly 
1               5                   10                  15      


Glu Ala Met Met Glu Asn Arg Ala Cys Pro Phe Gln Val Leu Pro His 
            20                  25                  30          


Glu Gln Ser Pro Pro Pro Pro Leu Gln Thr Ser Ser Asp Ala Glu Val 
        35                  40                  45              


Met Asp Val Gly Ser Gly Gly Asp Gly Gln Ser Glu Pro Pro Ala Asp 
    50                  55                  60                  


Asp Pro Phe Asn Phe Tyr Gly Ala Ser Leu Leu Ser Lys Gly Ser Phe 
65                  70                  75                  80  


Ser Lys Gly Arg Leu Leu Ile Asp Pro Asn Cys Ser Gly His Ser Pro 
                85                  90                  95      


Arg Thr Ala Arg His Ala Pro Ala Val Arg Lys Phe Ser Pro Asp Leu 
            100                 105                 110         


Lys Leu Leu Lys Asp Val Lys Ile Ser Val Ser Phe Thr Glu Ser Cys 
        115                 120                 125             


Arg Ser Lys Asp Arg Lys Val Leu Tyr Thr Gly Val Glu Arg Ser Thr 
    130                 135                 140                 


Arg Pro Glu Cys Gly Gln Leu Leu Ser Pro Val Ser Gly Asp Val His 
145                 150                 155                 160 


Ala Cys Pro Phe Gly Gly Ser Val Gly Asn Gly Val Gly Leu Gly Gly 
                165                 170                 175     


Glu Ser Ala Asp Lys Lys Asp Glu Glu Asn Glu Leu Asp Gln Glu Lys 
            180                 185                 190         


Arg Val Glu Tyr Ala Val Leu Asp Glu Leu Glu Asp Phe Thr Asp Asn 
        195                 200                 205             


Leu Glu Leu Asp Glu Glu Gly Thr Gly Gly Phe Thr Ala Lys Ala Ile 
    210                 215                 220                 


Val Gln Arg Asp Arg Val Asp Glu Glu Ala Leu Asn Phe Ser Tyr Glu 
225                 230                 235                 240 


Asp Asp Phe Asp Asn Asp Val Asp Ala Leu Leu Glu Glu Gly Leu Cys 
                245                 250                 255     


Ala Pro Lys Lys Arg Arg Met Glu Glu Lys Tyr Gly Gly Asp Ser Asp 
            260                 265                 270         


His Pro Ser Asp Gly Glu Thr Ser Val Gln Pro Met Met Thr Lys Ile 
        275                 280                 285             


Lys Thr Val Leu Lys Ser Arg Gly Arg Pro Pro Thr Glu Pro Leu Pro 
    290                 295                 300                 


Asp Gly Trp Ile Met Thr Phe His Asn Ser Gly Val Pro Val Tyr Leu 
305                 310                 315                 320 


His Arg Glu Ser Arg Val Val Thr Trp Ser Arg Pro Tyr Phe Leu Gly 
                325                 330                 335     


Thr Gly Ser Ile Arg Lys His Asp Pro Pro Leu Ser Ser Ile Pro Cys 
            340                 345                 350         


Leu His Tyr Lys Lys Met Lys Asp Asn Glu Glu Arg Glu Gln Asn Cys 
        355                 360                 365             


Asp Leu Ala Pro Ser Gly Glu Val Ser Pro Val Lys Pro Leu Gly Arg 
    370                 375                 380                 


Ser Ala Glu Leu Asp Phe Pro Leu Glu Glu Pro Asp Ser Met Gly Gly 
385                 390                 395                 400 


Asp Ser Gly Ser Met Asp Glu Lys Asp Pro Leu Gly Ala Glu Ala Ala 
                405                 410                 415     


Ala Gly Ala Leu Gly Gln Val Lys Ala Lys Val Glu Val Cys Lys Asp 
            420                 425                 430         


Glu Ser Val Asp Leu Glu Glu Phe Arg Asn Tyr Leu Glu Lys Arg Phe 
        435                 440                 445             


Asp Phe Glu Gln Val Thr Val Lys Lys Phe Arg Thr Trp Ala Glu Arg 
    450                 455                 460                 


Arg Gln Phe Asn Arg Glu Met Lys Arg Lys Gln Ala Glu Ser Glu Arg 
465                 470                 475                 480 


Pro Ile Leu Pro Ala Asn Gln Lys Leu Ile Thr Leu Ser Val Gln Asp 
                485                 490                 495     


Ala Pro Thr Lys Lys Glu Phe Val Ile Asn Pro Asn Gly Lys Ser Glu 
            500                 505                 510         


Val Cys Ile Leu His Glu Tyr Met Gln Arg Val Leu Lys Val Arg Pro 
        515                 520                 525             


Val Tyr Asn Phe Phe Glu Cys Glu Asn Pro Ser Glu Pro Phe Gly Ala 
    530                 535                 540                 


Ser Val Thr Ile Asp Gly Val Thr Tyr Gly Ser Gly Thr Ala Ser Ser 
545                 550                 555                 560 


Lys Lys Leu Ala Lys Asn Lys Ala Ala Arg Ala Thr Leu Glu Ile Leu 
                565                 570                 575     


Ile Pro Asp Phe Val Lys Gln Thr Ser Glu Glu Lys Pro Lys Asp Ser 
            580                 585                 590         


Glu Glu Leu Glu Tyr Phe Asn His Ile Ser Ile Glu Asp Ser Arg Val 
        595                 600                 605             


Tyr Glu Leu Thr Ser Lys Ala Gly Leu Leu Ser Pro Tyr Gln Ile Leu 
    610                 615                 620                 


His Glu Cys Leu Lys Arg Asn His Gly Met Gly Asp Thr Ser Ile Lys 
625                 630                 635                 640 


Phe Glu Val Val Pro Gly Lys Asn Gln Lys Ser Glu Tyr Val Met Ala 
                645                 650                 655     


Cys Gly Lys His Thr Val Arg Gly Trp Cys Lys Asn Lys Arg Val Gly 
            660                 665                 670         


Lys Gln Leu Ala Ser Gln Lys Ile Leu Gln Leu Leu His Pro His Val 
        675                 680                 685             


Lys Asn Trp Gly Ser Leu Leu Arg Met Tyr Gly Arg Glu Ser Ser Lys 
    690                 695                 700                 


Met Val Lys Gln Glu Thr Ser Asp Lys Ser Val Ile Glu Leu Gln Gln 
705                 710                 715                 720 


Tyr Ala Lys Lys Asn Arg Pro Asn Leu His Ile Leu Ser Lys Leu Gln 
                725                 730                 735     


Glu Glu Met Lys Arg Leu Ala Ala Glu Arg Glu Glu Thr Arg Lys Lys 
            740                 745                 750         


Pro Lys Met Ser Ile Val Ala Ser Ala Gln Pro Gly Gly Glu Pro Leu 
        755                 760                 765             


Cys Thr Val Asp Val 
    770             


<210>  7
<211>  611
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Glu Thr Tyr Glu Ser Pro Ser Pro Leu Pro Arg Glu Pro Ala Gly 
1               5                   10                  15      


Glu Ala Met Met Glu Asn Arg Ala Cys Pro Phe Gln Val Leu Pro His 
            20                  25                  30          


Glu Gln Ser Pro Pro Pro Pro Leu Gln Thr Ser Ser Asp Ala Glu Val 
        35                  40                  45              


Met Asp Val Gly Ser Gly Gly Asp Gly Gln Ser Glu Pro Pro Ala Asp 
    50                  55                  60                  


Asp Pro Phe Asn Phe Tyr Gly Ala Ser Leu Leu Ser Lys Gly Ser Phe 
65                  70                  75                  80  


Ser Lys Gly Arg Leu Leu Ile Asp Pro Asn Cys Ser Gly His Ser Pro 
                85                  90                  95      


Arg Thr Ala Arg His Ala Pro Ala Val Arg Lys Phe Ser Pro Asp Leu 
            100                 105                 110         


Lys Leu Leu Lys Asp Val Lys Ile Ser Val Ser Phe Thr Glu Ser Cys 
        115                 120                 125             


Arg Ser Lys Asp Arg Lys Val Leu Tyr Thr Gly Val Glu Arg Ser Thr 
    130                 135                 140                 


Arg Pro Glu Cys Gly Gln Leu Leu Ser Pro Val Ser Gly Asp Val His 
145                 150                 155                 160 


Ala Cys Pro Phe Gly Gly Ser Val Gly Asn Gly Val Gly Leu Gly Gly 
                165                 170                 175     


Glu Ser Ala Asp Lys Lys Asp Glu Glu Asn Glu Leu Asp Gln Glu Lys 
            180                 185                 190         


Arg Val Glu Tyr Ala Val Leu Asp Glu Leu Glu Asp Phe Thr Asp Asn 
        195                 200                 205             


Leu Glu Leu Asp Glu Glu Gly Thr Gly Gly Phe Thr Ala Lys Ala Ile 
    210                 215                 220                 


Val Gln Arg Asp Arg Val Asp Glu Glu Ala Leu Asn Phe Ser Tyr Glu 
225                 230                 235                 240 


Asp Asp Phe Asp Asn Asp Val Asp Ala Leu Leu Glu Glu Gly Leu Cys 
                245                 250                 255     


Ala Pro Lys Lys Arg Arg Met Glu Glu Lys Tyr Gly Gly Asp Ser Asp 
            260                 265                 270         


His Pro Ser Asp Gly Glu Thr Ser Val Gln Pro Met Met Thr Lys Ile 
        275                 280                 285             


Lys Thr Val Leu Lys Ser Arg Gly Arg Pro Pro Thr Glu Pro Leu Pro 
    290                 295                 300                 


Asp Gly Trp Ile Met Thr Phe His Asn Ser Gly Val Pro Val Tyr Leu 
305                 310                 315                 320 


His Arg Glu Ser Arg Val Val Thr Trp Ser Arg Pro Tyr Phe Leu Gly 
                325                 330                 335     


Thr Gly Ser Ile Arg Lys His Asp Pro Pro Leu Ser Ser Ile Pro Cys 
            340                 345                 350         


Leu His Tyr Lys Lys Met Lys Asp Asn Glu Glu Arg Glu Gln Asn Cys 
        355                 360                 365             


Asp Leu Ala Pro Ser Gly Glu Val Ser Pro Val Lys Pro Leu Gly Arg 
    370                 375                 380                 


Ser Ala Glu Leu Asp Phe Pro Leu Glu Glu Pro Asp Ser Met Gly Gly 
385                 390                 395                 400 


Asp Ser Gly Ser Met Asp Glu Lys Asp Pro Leu Gly Ala Glu Ala Ala 
                405                 410                 415     


Ala Gly Ala Leu Gly Gln Val Lys Ala Lys Val Glu Val Cys Lys Asp 
            420                 425                 430         


Glu Ser Val Asp Leu Glu Glu Phe Arg Asn Tyr Leu Glu Lys Arg Phe 
        435                 440                 445             


Asp Phe Glu Gln Val Thr Val Lys Lys Phe Arg Thr Trp Ala Glu Arg 
    450                 455                 460                 


Arg Gln Phe Asn Arg Glu Met Lys Arg Lys Gln Ala Glu Ser Glu Arg 
465                 470                 475                 480 


Pro Ile Leu Pro Ala Asn Gln Lys Leu Ile Thr Leu Ser Val Gln Asp 
                485                 490                 495     


Ala Pro Thr Lys Lys Glu Phe Val Ile Asn Pro Asn Gly Lys Ser Glu 
            500                 505                 510         


Val Cys Ile Leu His Glu Tyr Met Gln Arg Val Leu Lys Val Arg Pro 
        515                 520                 525             


Val Tyr Asn Phe Phe Glu Cys Glu Asn Pro Ser Glu Pro Phe Gly Ala 
    530                 535                 540                 


Ser Val Thr Ile Asp Gly Val Thr Tyr Gly Ser Gly Thr Ala Ser Ser 
545                 550                 555                 560 


Lys Lys Leu Ala Lys Asn Lys Ala Ala Arg Ala Thr Leu Glu Ile Leu 
                565                 570                 575     


Ile Pro Asp Phe Val Lys Gln Thr Ser Glu Glu Lys Pro Lys Asp Ser 
            580                 585                 590         


Glu Glu Leu Glu Val Ser Val Val Ile Leu Phe Ser Trp Glu Leu Pro 
        595                 600                 605             


Tyr Ser His 
    610     


<210>  8
<211>  588
<212>  PRT
<213>  Homo sapiens

<400>  8

Phe His Leu Ser Phe Gln Pro Val Cys Phe Ser Asp Asp Gln Met Pro 
1               5                   10                  15      


Ser Gly His Ala Gln Ser Pro Leu Arg Gly Ser Ser Val Cys Ser Leu 
            20                  25                  30          


Ile His Val Lys Leu Val Leu Gly Ala Lys Ala Trp Arg Gly Val Gly 
        35                  40                  45              


Ser Glu His Phe Ile Leu Gln Asp Asp Phe Asp Asn Asp Val Asp Ala 
    50                  55                  60                  


Leu Leu Glu Glu Gly Leu Cys Ala Pro Lys Lys Arg Arg Met Glu Glu 
65                  70                  75                  80  


Lys Tyr Gly Gly Asp Ser Asp His Pro Ser Asp Gly Glu Thr Ser Val 
                85                  90                  95      


Gln Pro Met Met Thr Lys Ile Lys Thr Val Leu Lys Ser Arg Gly Arg 
            100                 105                 110         


Pro Pro Thr Glu Pro Leu Pro Asp Gly Trp Ile Met Thr Phe His Asn 
        115                 120                 125             


Ser Gly Val Pro Val Tyr Leu His Arg Glu Ser Arg Val Val Thr Trp 
    130                 135                 140                 


Ser Arg Pro Tyr Phe Leu Gly Thr Gly Ser Ile Arg Lys His Asp Pro 
145                 150                 155                 160 


Pro Leu Ser Ser Ile Pro Cys Leu His Tyr Lys Lys Met Lys Asp Asn 
                165                 170                 175     


Glu Glu Arg Glu Gln Asn Cys Asp Leu Ala Pro Ser Gly Glu Val Ser 
            180                 185                 190         


Pro Val Lys Pro Leu Gly Arg Ser Ala Glu Leu Asp Phe Pro Leu Glu 
        195                 200                 205             


Glu Pro Asp Ser Met Gly Gly Asp Ser Gly Ser Met Asp Glu Lys Asp 
    210                 215                 220                 


Pro Leu Gly Ala Glu Ala Ala Ala Gly Ala Leu Gly Gln Val Lys Ala 
225                 230                 235                 240 


Lys Val Glu Val Cys Lys Asp Glu Ser Val Asp Leu Glu Glu Phe Arg 
                245                 250                 255     


Asn Tyr Leu Glu Lys Arg Phe Asp Phe Glu Gln Val Thr Val Lys Lys 
            260                 265                 270         


Phe Arg Thr Trp Ala Glu Arg Arg Gln Phe Asn Arg Glu Met Lys Arg 
        275                 280                 285             


Lys Gln Ala Glu Ser Glu Arg Pro Ile Leu Pro Ala Asn Gln Lys Leu 
    290                 295                 300                 


Ile Thr Leu Ser Val Gln Asp Ala Pro Thr Lys Lys Glu Phe Val Ile 
305                 310                 315                 320 


Asn Pro Asn Gly Lys Ser Glu Val Cys Ile Leu His Glu Tyr Met Gln 
                325                 330                 335     


Arg Val Leu Lys Val Arg Pro Val Tyr Asn Phe Phe Glu Cys Glu Asn 
            340                 345                 350         


Pro Ser Glu Pro Phe Gly Ala Ser Val Thr Ile Asp Gly Val Thr Tyr 
        355                 360                 365             


Gly Ser Gly Thr Ala Ser Ser Lys Lys Leu Ala Lys Asn Lys Ala Ala 
    370                 375                 380                 


Arg Ala Thr Leu Glu Ile Leu Ile Pro Asp Phe Val Lys Gln Thr Ser 
385                 390                 395                 400 


Glu Glu Lys Pro Lys Asp Ser Glu Glu Leu Glu Tyr Phe Asn His Ile 
                405                 410                 415     


Ser Ile Glu Asp Ser Arg Val Tyr Glu Leu Thr Ser Lys Ala Gly Leu 
            420                 425                 430         


Leu Ser Pro Tyr Gln Ile Leu His Glu Cys Leu Lys Arg Asn His Gly 
        435                 440                 445             


Met Gly Asp Thr Ser Ile Lys Phe Glu Val Val Pro Gly Lys Asn Gln 
    450                 455                 460                 


Lys Ser Glu Tyr Val Met Ala Cys Gly Lys His Thr Val Arg Gly Trp 
465                 470                 475                 480 


Cys Lys Asn Lys Arg Val Gly Lys Gln Leu Ala Ser Gln Lys Ile Leu 
                485                 490                 495     


Gln Leu Leu His Pro His Val Lys Asn Trp Gly Ser Leu Leu Arg Met 
            500                 505                 510         


Tyr Gly Arg Glu Ser Ser Lys Met Val Lys Gln Glu Thr Ser Asp Lys 
        515                 520                 525             


Ser Val Ile Glu Leu Gln Gln Tyr Ala Lys Lys Asn Arg Pro Asn Leu 
    530                 535                 540                 


His Ile Leu Ser Lys Leu Gln Glu Glu Met Lys Arg Leu Ala Ala Glu 
545                 550                 555                 560 


Arg Glu Glu Thr Arg Lys Lys Pro Lys Met Ser Ile Val Ala Ser Ala 
                565                 570                 575     


Gln Pro Gly Gly Glu Pro Leu Cys Thr Val Asp Val 
            580                 585             


<210>  9
<211>  773
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Glu Thr Tyr Glu Ser Pro Ser Pro Leu Pro His Glu Pro Thr Gly 
1               5                   10                  15      


Glu Ala Met Met Glu Asn Arg Ala Cys Pro Phe Gln Val Leu Pro His 
            20                  25                  30          


Glu Gln Ser Pro Pro Pro Pro Leu Gln Thr Ser Ser Asp Ala Glu Val 
        35                  40                  45              


Met Asp Val Gly Ser Gly Gly Asp Gly Gln Ser Glu Pro Pro Ala Asp 
    50                  55                  60                  


Asp Pro Phe Asn Phe Tyr Gly Ala Ser Leu Leu Ser Lys Gly Ser Phe 
65                  70                  75                  80  


Ser Lys Gly Arg Leu Leu Ile Asp Pro Asn Cys Ser Gly His Ser Pro 
                85                  90                  95      


Arg Thr Ala Arg His Ala Pro Ala Val Arg Lys Phe Ser Pro Asp Leu 
            100                 105                 110         


Lys Leu Leu Lys Asp Val Lys Ile Ser Val Ser Phe Thr Glu Ser Cys 
        115                 120                 125             


Arg Ser Lys Asp Arg Lys Val Leu Tyr Thr Gly Val Glu Arg Ser Thr 
    130                 135                 140                 


Arg Pro Glu Cys Ser Gln Leu Leu Ser Pro Val Cys Gly Asp Val His 
145                 150                 155                 160 


Ala Cys Pro Phe Gly Gly Ser Val Gly Asn Gly Val Gly Leu Gly Gly 
                165                 170                 175     


Glu Ser Thr Asp Lys Lys Asp Glu Glu Asn Glu Leu Asp Gln Glu Lys 
            180                 185                 190         


Arg Val Glu Tyr Ala Val Leu Asp Glu Leu Glu Asp Phe Thr Asp Asn 
        195                 200                 205             


Leu Glu Leu Asp Glu Glu Gly Thr Gly Gly Phe Thr Ala Asn Ala Ile 
    210                 215                 220                 


Val Gln Arg Asp Arg Val Asp Glu Glu Ala Leu Asn Phe Ser Tyr Glu 
225                 230                 235                 240 


Asp Asp Phe Asp Asn Asp Val Asp Ala Leu Leu Glu Glu Gly Leu Cys 
                245                 250                 255     


Ala Pro Lys Lys Arg Arg Met Glu Glu Lys Tyr Gly Gly Asp Ser Asp 
            260                 265                 270         


His Pro Ser Asp Gly Glu Thr Ser Val Gln Pro Met Met Thr Lys Ile 
        275                 280                 285             


Lys Thr Val Leu Lys Ser Arg Gly Arg Pro Pro Thr Glu Pro Leu Pro 
    290                 295                 300                 


Asp Gly Trp Ile Met Thr Phe His Asn Ser Gly Val Pro Val Tyr Leu 
305                 310                 315                 320 


His Arg Glu Ser Arg Val Val Thr Trp Ser Arg Pro Tyr Phe Leu Gly 
                325                 330                 335     


Thr Gly Ser Ile Arg Lys His Asp Pro Pro Leu Ser Ser Ile Pro Cys 
            340                 345                 350         


Leu His Tyr Lys Lys Met Lys Asp Asn Glu Glu Arg Glu Gln Ser Cys 
        355                 360                 365             


Asp Leu Ala Pro Ser Gly Glu Val Ser Pro Val Lys Pro Leu Gly Arg 
    370                 375                 380                 


Ser Ala Glu Leu Asp Phe Pro Leu Glu Glu Pro Asp Ser Leu Gly Gly 
385                 390                 395                 400 


Asp Ser Gly Ser Leu Asp Glu Lys Asp Pro Leu Gly Ala Glu Ala Ala 
                405                 410                 415     


Ala Gly Ala Leu Gly Gln Val Arg Ala Lys Val Glu Val Cys Lys Asp 
            420                 425                 430         


Glu Ser Val Asp Leu Glu Glu Phe Arg Asn Tyr Leu Glu Lys Arg Phe 
        435                 440                 445             


Asp Phe Glu Gln Val Thr Val Lys Lys Phe Arg Thr Trp Ala Glu Arg 
    450                 455                 460                 


Arg Gln Phe Asn Arg Glu Met Lys Arg Lys Gln Ala Glu Ser Glu Arg 
465                 470                 475                 480 


Pro Ile Leu Pro Ala Asn Gln Lys Leu Ile Thr Leu Ser Val Gln Asp 
                485                 490                 495     


Ala Pro Thr Lys Lys Glu Phe Val Ile Asn Pro Asn Gly Lys Ser Glu 
            500                 505                 510         


Val Cys Ile Leu His Glu Tyr Met Gln Arg Val Leu Lys Val Arg Pro 
        515                 520                 525             


Val Tyr Asn Phe Phe Glu Cys Glu Asn Pro Ser Glu Pro Phe Gly Ala 
    530                 535                 540                 


Ser Val Thr Ile Asp Gly Val Thr Tyr Gly Ser Gly Thr Ala Ser Ser 
545                 550                 555                 560 


Lys Lys Leu Ala Lys Asn Lys Ala Ala Arg Ala Thr Leu Glu Ile Leu 
                565                 570                 575     


Ile Pro Asp Phe Val Lys Gln Thr Ser Glu Glu Lys Pro Lys Asp Ser 
            580                 585                 590         


Glu Glu Leu Glu Tyr Phe Asn His Ile Ser Ile Glu Asp Ser Arg Val 
        595                 600                 605             


Tyr Glu Leu Thr Ser Lys Ala Gly Leu Leu Ser Pro Tyr Gln Ile Leu 
    610                 615                 620                 


His Glu Cys Leu Lys Arg Asn His Gly Met Gly Asp Thr Ser Ile Lys 
625                 630                 635                 640 


Phe Glu Val Val Pro Gly Lys Asn Gln Lys Ser Glu Tyr Val Met Ala 
                645                 650                 655     


Cys Gly Lys His Thr Val Arg Gly Trp Cys Lys Asn Lys Arg Val Gly 
            660                 665                 670         


Lys Gln Leu Ala Ser Gln Lys Ile Leu Gln Leu Leu His Pro His Val 
        675                 680                 685             


Lys Asn Trp Gly Ser Leu Leu Arg Met Tyr Gly Arg Glu Ser Ser Lys 
    690                 695                 700                 


Met Val Lys Gln Glu Thr Ser Asp Lys Ser Val Ile Glu Leu Gln Gln 
705                 710                 715                 720 


Tyr Ala Lys Lys Asn Arg Pro Asn Leu His Ile Leu Ser Lys Leu Gln 
                725                 730                 735     


Glu Glu Met Lys Arg Leu Ala Ala Glu Arg Glu Glu Thr Arg Lys Lys 
            740                 745                 750         


Pro Lys Met Ser Ile Val Ala Ser Ala Gln Pro Gly Gly Glu Pro Leu 
        755                 760                 765             


Cys Thr Val Asp Val 
    770             


<210>  10
<211>  773
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Glu Thr Tyr Glu Ser Pro Ser Pro Leu Pro His Glu Pro Thr Gly 
1               5                   10                  15      


Glu Ala Met Met Glu Asn Arg Ala Cys Pro Phe Gln Val Leu Pro His 
            20                  25                  30          


Glu Gln Ser Pro Pro Pro Pro Leu Gln Thr Ser Ser Asp Ala Glu Val 
        35                  40                  45              


Met Asp Val Gly Ser Gly Gly Asp Gly Gln Ser Glu Pro Pro Ala Asp 
    50                  55                  60                  


Asp Pro Phe Asn Phe Tyr Gly Ala Ser Leu Leu Ser Lys Gly Ser Phe 
65                  70                  75                  80  


Ser Lys Gly Arg Leu Leu Ile Asp Pro Asn Cys Ser Gly His Ser Pro 
                85                  90                  95      


Arg Thr Ala Arg His Ala Pro Ala Val Arg Lys Phe Ser Pro Asp Leu 
            100                 105                 110         


Lys Leu Leu Lys Asp Val Lys Ile Ser Val Ser Phe Thr Glu Ser Cys 
        115                 120                 125             


Arg Ser Lys Asp Arg Lys Val Leu Tyr Thr Gly Val Glu Arg Ser Thr 
    130                 135                 140                 


Arg Pro Glu Cys Ser Gln Leu Leu Ser Pro Val Cys Gly Asp Val His 
145                 150                 155                 160 


Ala Cys Pro Phe Gly Gly Ser Val Gly Asn Gly Val Gly Leu Gly Gly 
                165                 170                 175     


Glu Ser Thr Asp Lys Lys Asp Glu Glu Asn Glu Leu Asp Gln Glu Lys 
            180                 185                 190         


Arg Val Glu Tyr Ala Val Leu Asp Glu Leu Glu Asp Phe Thr Asp Asn 
        195                 200                 205             


Leu Glu Leu Asp Glu Glu Gly Thr Gly Gly Phe Thr Ala Asn Ala Ile 
    210                 215                 220                 


Val Gln Arg Asp Arg Val Asp Glu Glu Ala Leu Asn Phe Ser Tyr Glu 
225                 230                 235                 240 


Asp Asp Phe Asp Asn Asp Val Asp Ala Leu Leu Glu Glu Gly Leu Cys 
                245                 250                 255     


Ala Pro Lys Lys Arg Arg Met Glu Glu Lys Tyr Gly Gly Asp Ser Asp 
            260                 265                 270         


His Pro Ser Asp Gly Glu Thr Ser Val Gln Pro Met Met Thr Lys Ile 
        275                 280                 285             


Lys Thr Val Leu Lys Ser Arg Gly Arg Pro Pro Thr Glu Pro Leu Pro 
    290                 295                 300                 


Asp Gly Trp Ile Met Thr Phe His Asn Ser Gly Val Pro Val Tyr Leu 
305                 310                 315                 320 


His Arg Glu Ser Arg Val Val Thr Trp Ser Arg Pro Tyr Phe Leu Gly 
                325                 330                 335     


Thr Gly Ser Ile Arg Lys His Asp Pro Pro Leu Ser Ser Ile Pro Cys 
            340                 345                 350         


Leu His Tyr Lys Lys Met Lys Asp Asn Glu Glu Arg Glu Gln Ser Cys 
        355                 360                 365             


Asp Leu Ala Pro Ser Gly Glu Val Ser Pro Val Lys Pro Leu Gly Arg 
    370                 375                 380                 


Ser Ala Glu Leu Asp Phe Pro Leu Glu Glu Pro Asp Ser Leu Gly Gly 
385                 390                 395                 400 


Asp Ser Gly Ser Leu Asp Glu Lys Asp Pro Leu Gly Ala Glu Ala Ala 
                405                 410                 415     


Ala Gly Ala Leu Gly Gln Val Arg Ala Lys Val Glu Val Cys Lys Asp 
            420                 425                 430         


Glu Ser Val Asp Leu Glu Glu Phe Arg Asn Tyr Leu Glu Lys Arg Phe 
        435                 440                 445             


Asp Phe Glu Gln Val Thr Val Lys Lys Phe Arg Thr Trp Ala Glu Arg 
    450                 455                 460                 


Arg Gln Phe Asn Arg Glu Met Lys Arg Lys Gln Ala Glu Ser Glu Arg 
465                 470                 475                 480 


Pro Ile Leu Pro Ala Asn Gln Lys Leu Ile Thr Leu Ser Val Gln Asp 
                485                 490                 495     


Ala Pro Thr Lys Lys Glu Phe Val Ile Asn Pro Asn Gly Lys Ser Glu 
            500                 505                 510         


Val Cys Ile Leu His Glu Tyr Met Gln Arg Val Leu Lys Val Arg Pro 
        515                 520                 525             


Val Tyr Asn Phe Phe Glu Cys Glu Asn Pro Ser Glu Pro Phe Gly Ala 
    530                 535                 540                 


Ser Val Thr Ile Asp Gly Val Thr Tyr Gly Ser Gly Thr Ala Ser Ser 
545                 550                 555                 560 


Lys Lys Leu Ala Lys Asn Lys Ala Ala Arg Ala Thr Leu Glu Ile Leu 
                565                 570                 575     


Ile Pro Asp Phe Val Lys Gln Thr Ser Glu Glu Lys Pro Lys Asp Ser 
            580                 585                 590         


Glu Glu Leu Glu Tyr Phe Asn His Ile Ser Ile Glu Asp Ser Arg Val 
        595                 600                 605             


Tyr Glu Leu Thr Ser Lys Ala Gly Leu Leu Ser Pro Tyr Gln Ile Leu 
    610                 615                 620                 


His Glu Cys Leu Lys Arg Asn His Gly Met Gly Asp Thr Ser Ile Lys 
625                 630                 635                 640 


Phe Glu Val Val Pro Gly Lys Asn Gln Lys Ser Glu Tyr Val Met Ala 
                645                 650                 655     


Cys Gly Lys His Thr Val Arg Gly Trp Cys Lys Asn Lys Arg Val Gly 
            660                 665                 670         


Lys Gln Leu Ala Ser Gln Lys Ile Leu Gln Leu Leu His Pro His Val 
        675                 680                 685             


Lys Asn Trp Gly Ser Leu Leu Arg Met Tyr Gly Arg Glu Ser Ser Lys 
    690                 695                 700                 


Met Val Lys Gln Glu Thr Ser Asp Lys Ser Val Ile Glu Leu Gln Gln 
705                 710                 715                 720 


Tyr Ala Lys Lys Asn Arg Pro Asn Leu His Ile Leu Ser Lys Leu Gln 
                725                 730                 735     


Glu Glu Met Lys Arg Leu Ala Ala Glu Arg Glu Glu Thr Arg Lys Lys 
            740                 745                 750         


Pro Lys Met Ser Ile Val Ala Ser Ala Gln Pro Gly Gly Glu Pro Leu 
        755                 760                 765             


Cys Thr Val Asp Val 
    770             


<210>  11
<211>  620
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Glu Thr Tyr Glu Ser Pro Ser Pro Leu Pro His Glu Pro Thr Gly 
1               5                   10                  15      


Glu Ala Met Met Glu Asn Arg Ala Cys Pro Phe Gln Val Leu Pro His 
            20                  25                  30          


Glu Gln Ser Pro Pro Pro Pro Leu Gln Thr Ser Ser Asp Ala Glu Val 
        35                  40                  45              


Met Asp Val Gly Ser Gly Gly Asp Gly Gln Ser Glu Pro Pro Ala Asp 
    50                  55                  60                  


Asp Pro Phe Asn Phe Tyr Gly Ala Ser Leu Leu Ser Lys Gly Ser Phe 
65                  70                  75                  80  


Ser Lys Gly Arg Leu Leu Ile Asp Pro Asn Cys Ser Gly His Ser Pro 
                85                  90                  95      


Arg Thr Ala Arg His Ala Pro Ala Val Arg Lys Phe Ser Pro Asp Leu 
            100                 105                 110         


Lys Leu Leu Lys Asp Val Lys Ile Ser Val Ser Phe Thr Glu Ser Cys 
        115                 120                 125             


Arg Ser Lys Asp Arg Lys Val Leu Tyr Thr Gly Val Glu Arg Ser Thr 
    130                 135                 140                 


Arg Pro Glu Cys Ser Gln Leu Leu Ser Pro Val Cys Gly Asp Val His 
145                 150                 155                 160 


Ala Cys Pro Phe Gly Gly Ser Val Gly Asn Gly Val Gly Leu Gly Gly 
                165                 170                 175     


Glu Ser Thr Asp Lys Lys Asp Glu Glu Asn Glu Leu Asp Gln Glu Lys 
            180                 185                 190         


Arg Val Glu Tyr Ala Val Leu Asp Glu Leu Glu Asp Phe Thr Asp Asn 
        195                 200                 205             


Leu Glu Leu Asp Glu Glu Gly Thr Gly Gly Phe Thr Ala Asn Ala Ile 
    210                 215                 220                 


Val Gln Arg Asp Arg Val Asp Glu Glu Ala Leu Asn Phe Ser Tyr Glu 
225                 230                 235                 240 


Asp Asp Phe Asp Asn Asp Val Asp Ala Leu Leu Glu Glu Gly Leu Cys 
                245                 250                 255     


Ala Pro Lys Lys Arg Arg Met Glu Glu Lys Tyr Gly Gly Asp Ser Asp 
            260                 265                 270         


His Pro Ser Asp Gly Glu Thr Ser Val Gln Pro Met Met Thr Lys Ile 
        275                 280                 285             


Lys Thr Val Leu Lys Ser Arg Gly Arg Pro Pro Thr Glu Pro Leu Pro 
    290                 295                 300                 


Asp Gly Trp Ile Met Thr Phe His Asn Ser Gly Val Pro Val Tyr Leu 
305                 310                 315                 320 


His Arg Glu Ser Arg Val Val Thr Trp Ser Arg Pro Tyr Phe Leu Gly 
                325                 330                 335     


Thr Gly Ser Ile Arg Lys His Asp Pro Pro Leu Ser Ser Ile Pro Cys 
            340                 345                 350         


Leu His Tyr Lys Lys Met Lys Asp Asn Glu Glu Arg Glu Gln Ser Cys 
        355                 360                 365             


Asp Leu Ala Pro Ser Gly Glu Val Ser Pro Val Lys Pro Leu Gly Arg 
    370                 375                 380                 


Ser Ala Glu Leu Asp Phe Pro Leu Glu Glu Pro Asp Ser Leu Gly Gly 
385                 390                 395                 400 


Asp Ser Gly Ser Leu Asp Glu Lys Asp Pro Leu Gly Ala Glu Ala Ala 
                405                 410                 415     


Ala Gly Ala Leu Gly Gln Val Arg Ala Lys Val Glu Val Cys Lys Asp 
            420                 425                 430         


Glu Ser Val Asp Leu Glu Glu Phe Arg Asn Tyr Leu Glu Lys Arg Phe 
        435                 440                 445             


Asp Phe Glu Gln Val Thr Val Lys Lys Phe Arg Thr Trp Ala Glu Arg 
    450                 455                 460                 


Arg Gln Phe Asn Arg Glu Met Lys Arg Lys Gln Ala Glu Ser Glu Arg 
465                 470                 475                 480 


Pro Ile Leu Pro Ala Asn Gln Lys Leu Ile Thr Leu Ser Val Gln Asp 
                485                 490                 495     


Ala Pro Thr Lys Lys Glu Phe Val Ile Asn Pro Asn Gly Lys Ser Glu 
            500                 505                 510         


Val Cys Ile Leu His Glu Tyr Met Gln Arg Val Leu Lys Val Arg Pro 
        515                 520                 525             


Val Tyr Asn Phe Phe Glu Cys Glu Asn Pro Ser Glu Pro Phe Gly Ala 
    530                 535                 540                 


Ser Val Thr Ile Asp Gly Val Thr Tyr Gly Ser Gly Thr Ala Ser Ser 
545                 550                 555                 560 


Lys Lys Leu Ala Lys Asn Lys Ala Ala Arg Ala Thr Leu Glu Ile Leu 
                565                 570                 575     


Ile Pro Asp Phe Val Lys Gln Thr Ser Glu Glu Lys Pro Lys Asp Ser 
            580                 585                 590         


Glu Glu Leu Glu Val Ser Val Gly Ile Leu Phe Ser Trp Glu Leu His 
        595                 600                 605             


Leu Pro Tyr Ile Ala Ser Thr Arg Leu Arg Thr Met 
    610                 615                 620 


<210>  12
<211>  8448
<212>  DNA
<213>  Artificial

<220>
<223>  nucleic sequence coding for the fusion protein DGCR8-GFP

<400>  12
gacggatcgg gagatctccc gatcccctat ggtcgactct cagtacaatc tgctctgatg     60

ccgcatagtt aagccagtat ctgctccctg cttgtgtgtt ggaggtcgct gagtagtgcg    120

cgagcaaaat ttaagctaca acaaggcaag gcttgaccga caattgcatg aagaatctgc    180

ttagggttag gcgttttgcg ctgcttcgcg atgtacgggc cagatatacg cgttgacatt    240

gattattgac tagttattaa tagtaatcaa ttacggggtc attagttcat agcccatata    300

tggagttccg cgttacataa cttacggtaa atggcccgcc tggctgaccg cccaacgacc    360

cccgcccatt gacgtcaata atgacgtatg ttcccatagt aacgccaata gggactttcc    420

attgacgtca atgggtggac tatttacggt aaactgccca cttggcagta catcaagtgt    480

atcatatgcc aagtacgccc cctattgacg tcaatgacgg taaatggccc gcctggcatt    540

atgcccagta catgacctta tgggactttc ctacttggca gtacatctac gtattagtca    600

tcgctattac catggtgatg cggttttggc agtacatcaa tgggcgtgga tagcggtttg    660

actcacgggg atttccaagt ctccacccca ttgacgtcaa tgggagtttg ttttggcacc    720

aaaatcaacg ggactttcca aaatgtcgta acaactccgc cccattgacg caaatgggcg    780

gtaggcgtgt acggtgggag gtctatataa gcagagctct ctggctaact agagaaccca    840

ctgcttactg gcttatcgaa attaatacga ctcactatag ggagacccaa gcttggtacc    900

gagctcggat cgatccatcg atagtgtggt ggaattctga tggtgagcaa gggcgaggag    960

ctgttcaccg gggtggtgcc catcctggtc gagctggacg gcgacgtaaa cggccacaag   1020

ttcagcgtgt ccggcgaggg cgagggcgat gccacctacg gcaagctgac cctgaagttc   1080

atctgcacca ccggcaagct gcccgtgccc tggcccaccc tcgtgaccac cctgacctac   1140

ggcgtgcagt gcttcagccg ctaccccgac cacatgaagc agcacgactt cttcaagtcc   1200

gccatgcccg aaggctacgt ccaggagcgc accatcttct tcaaggacga cggcaactac   1260

aagacccgcg ccgaggtgaa gttcgagggc gacaccctgg tgaaccgcat cgagctgaag   1320

ggcatcgact tcaaggagga cggcaacatc ctggggcaca agctggagta caactacaac   1380

agccacaacg tctatatcat ggccgacaag cagaagaacg gcatcaaggt gaacttcaag   1440

atccgccaca acatcgagga cggcagcgtg cagctcgccg accactacca gcagaacacc   1500

cccatcggcg acggccccgt gctgctgccc gacaaccact acctgagcac ccagtccgcc   1560

ctgagcaaag accccaacga gaagcgcgat cacatggtcc tgctggagtt cgtgaccgcc   1620

gccgggatca ctctcggcat ggacgagctg tacaagggaa ttctgatcgc cgccgccatg   1680

gactacaagg acgacgatga caagtaccct tatgacgtgc ccgattacgc tttgaaccag   1740

atatcaacaa gtttgtacaa aaaagcaggc tccaccatgg gaaccaattc agtcgacatg   1800

gagacagatg agagcccctc tccgctcccg tgtgggcccg caggagaagc ggtgatggag   1860

agccgagctc gccccttcca agcgctgccc cgtgagcagt ctccaccacc tcccctgcaa   1920

acgtccagtg gtgcagaggt aatggacgtt ggctctggtg gtgatggaca gtccgaactc   1980

cctgctgagg accccttcaa cttctacgga gcttctcttc tctccaaagg atccttctct   2040

aagggccgcc tcctcataga cccgaactgt agtggccaca gcccgcgcac cgcccggcac   2100

gcacctgcgg tccggaagtt ctcccctgac cttaagttgc ttaaggatgt aaagattagc   2160

gtgagcttta ccgagagctg caggagtaag gacaggaagg tgctgtacac aggagcagag   2220

cgcgacgtgc gggcggagtg cggtctgctc cttagccctg tcagtgggga cgtgcatgct   2280

tgtccctttg gcgggagtgt tggtgacggg gtaggcatag ggggtgagag tgctgataag   2340

aaggatgagg agaatgagct ggatcaggaa aagagagtgg agtatgcagt gctcgatgag   2400

ttagaagatt ttactgacaa tttggagcta gatgaagaag gagcaggcgg gttcacggct   2460

aaagcaatcg ttcagagaga cagagtggat gaagaggcct tgaatttccc ctacgaggat   2520

gactttgaca acgatgtgga tgctctgctg gaagaaggcc tttgtgcccc caaaaagagg   2580

cgaacagagg aaaaatatgg cggagacagc gaccatccgt ccgatggaga gacaagtgtg   2640

cagccgatga tgaccaagat taaaacagtg ctcaaaagtc gtggccgccc acctacagag   2700

ccgctgcccg acgggtggat catgacattc cataactctg gagtcccggt gtacctacac   2760

agagagtctc gggtggtcac ctggtccagg ccatacttct tgggaacggg aagcatacgg   2820

aaacacgacc ctcctctgag tagcatccct tgtctgcatt ataagaaaat gaaggacaac   2880

gaggaacggg agcaaagcag tgacctcacc cctagtgggg atgtgtcccc cgtcaagccc   2940

ctgagccgat ctgcagagct ggagtttccc ctggatgagc ctgactctat gggtgctgac   3000

ccggggcccc cggacgagaa agacccacta ggggctgagg cagcccctgg ggccctgggg   3060

caggtgaagg ccaaagtcga ggtgtgcaaa gatgaatccg ttgatctcga ggaatttcga   3120

agctacctgg agaagcgttt tgactttgag caagttactg tgaaaaaatt caggacttgg   3180

gctgagcggc ggcaattcaa tcgggaaatg aagcggaagc aggcggagtc cgagaggccc   3240

atcttgccag ccaatcagaa gctcattact ttatcagtgc aagatgcacc cacaaagaaa   3300

gagtttgtta ttaaccccaa cgggaaatcc gaggtctgca tcctgcacga gtacatgcag   3360

cgtgtcctca aggtccgccc tgtctataat ttctttgaat gtgagaaccc aagtgagcct   3420

tttggtgcct cggtgaccat tgatggtgtg acttacggat ctggaactgc aagcagcaaa   3480

aaacttgcga agaataaagc tgcccgagct acactggaaa tcctcatccc tgactttgtt   3540

aaacagacct ctgaagagaa gcccaaagac agtgaagaac tcgagtattt taaccacatc   3600

agcatcgagg actcgcgggt ctacgagctg accagcaagg ctgggctgtt gtctccatat   3660

cagatcctcc acgagtgcct taaaagaaac catgggatgg gtgacacgtc tatcaagttt   3720

gaagtggttc ctgggaaaaa ccagaagagt gaatacgtca tggcgtgtgg caagcacaca   3780

gtgcgcgggt ggtgtaagaa caagagagtt ggaaagcagt tagcctcaca gaagatcctt   3840

cagctgctgc acccacatgt caagaactgg gggtctttac tgcgcatgta tggccgtgag   3900

agcagcaaga tggtcaagca ggagacatcg gacaagagtg tgattgagct gcagcagtat   3960

gccaagaaga acaagcccaa cctgcacatc ctcagcaagc tccaagagga gatgaagagg   4020

ctagctgagg aaagggagga gactcgaaag aagcccaaga tgtccattgt ggcgtccgcc   4080

cagcctggcg gtgagcccct gtgcaccgtg gacgtgtgag cggccgcact cgagatatct   4140

agacccagct ttcttgtaca aagtggttga tatccagcac agtggcggcc gctcaagtct   4200

agagggcccg cggttcgaag gtaagcctat ccctaaccct ctcctcggtc tcgattctac   4260

gcgtacctga tccgcggccg catagataac tgatccagtg tgctggaatt aattcgctgt   4320

ctgcgagggc cagctgttgg ggtgagtact ccctctcaaa agcgggcatg acttctgcgc   4380

taagattgtc agtttccaaa aacgaggagg atttgatatt cacctggccc gcggtgatgc   4440

ctttgagggt ggccgcgtcc atctggtcag aaaagacaat ctttttgttg tcaagcttga   4500

ggtgtggcag gcttgagatc tggccataca cttgagtgac aatgacatcc actttgcctt   4560

tctctccaca ggtgtccact cccaggtcca actgcaggtc gagcatgcat ctagggcggc   4620

caattccgcc cctctccctc ccccccccct aacgttactg gccgaagccg cttggaataa   4680

ggccggtgtg cgtttgtcta tatgtgattt tccaccatat tgccgtcttt tggcaatgtg   4740

agggcccgga aacctggccc tgtcttcttg acgagcattc ctaggggtct ttcccctctc   4800

gccaaaggaa tgcaaggtct gttgaatgtc gtgaaggaag cagttcctct ggaagcttct   4860

tgaagacaaa caacgtctgt agcgaccctt tgcaggcagc ggaacccccc acctggcgac   4920

aggtgcctct gcggccaaaa gccacgtgta taagatacac ctgcaaaggc ggcacaaccc   4980

cagtgccacg ttgtgagttg gatagttgtg gaaagagtca aatggctctc ctcaagcgta   5040

ttcaacaagg ggctgaagga tgcccagaag gtaccccatt gtatgggatc tgatctgggg   5100

cctcggtgca catgctttac atgtgtttag tcgaggttaa aaaaacgtct aggccccccg   5160

aaccacgggg acgtggtttt cctttgaaaa acacgatgat aagcttgcca caacccacaa   5220

ggagacgacc ttccatgacc gagtacaagc ccacggtgcg cctcgccacc cgcgacgacg   5280

tcccccgggc cgtacgcacc ctcgccgccg cgttcgccga ctaccccgcc acgcgccaca   5340

ccgtcgaccc ggaccgccac atcgagcggg tcaccgagct gcaagaactc ttcctcacgc   5400

gcgtcgggct cgacatcggc aaggtgtggg tcgcggacga cggcgccgcg gtggcggtct   5460

ggaccacgcc ggagagcgtc gaagcggggg cggtgttcgc cgagatcggc ccgcgcatgg   5520

ccgagttgag cggttcccgg ctggccgcgc agcaacagat ggaaggcctc ctggcgccgc   5580

accggcccaa ggagcccgcg tggttcctgg ccaccgtcgg cgtctcgccc gaccaccagg   5640

gcaagggtct gggcagcgcc gtcgtgctcc ccggagtgga ggcggccgag cgcgccgggg   5700

tgcccgcctt cctggagacc tccgcgcccc gcaacctccc cttctacgag cggctcggct   5760

tcaccgtcac cgccgacgtc gagtgcccga aggaccgcgc gacctggtgc atgacccgca   5820

agcccggtgc ctgacgcccg ccccacgacc cgcagcgccc gaccgaaagg agcgcacgac   5880

cccatggctc cgaccgaagc cgacccgggc ggccccgccg accccgcacc cgcccccgag   5940

gcccaccgac tctagataac tgatcataat cagccatacc acatttgtag aggttttact   6000

tgctttaaaa aacctcccac acctccccct gaacctgaaa cataaaatga atgcaattgt   6060

tgttgttaac ttgtttattg cagcttataa tggttacaaa taaagcaata gcatcacaaa   6120

tttcacaaat aaagcatttt tttcactgca ttctagttgt ggtttgtcca aactcatcaa   6180

tgtatcttaa cgcgtcgagt gcattctagt tgtggtttgt ccaaactcat caatgtatct   6240

tatcatgtct gtataccgtc gacctctagc tagagcttgg cgtaatcatg gtcatagctg   6300

tttcctgtgt gaaattgtta tccgctcaca attccacaca acatacgagc cggaagcata   6360

aagtgtaaag cctggggtgc ctaatgagtg agctaactca cattaattgc gttgcgctca   6420

ctgcccgctt tccagtcggg aaacctgtcg tgccagctgc attaatgaat cggccaacgc   6480

gcggggagag gcggtttgcg tattgggcgc tcttccgctt cctcgctcac tgactcgctg   6540

cgctcggtcg ttcggctgcg gcgagcggta tcagctcact caaaggcggt aatacggtta   6600

tccacagaat caggggataa cgcaggaaag aacatgtgag caaaaggcca gcaaaaggcc   6660

aggaaccgta aaaaggccgc gttgctggcg tttttccata ggctccgccc ccctgacgag   6720

catcacaaaa atcgacgctc aagtcagagg tggcgaaacc cgacaggact ataaagatac   6780

caggcgtttc cccctggaag ctccctcgtg cgctctcctg ttccgaccct gccgcttacc   6840

ggatacctgt ccgcctttct cccttcggga agcgtggcgc tttctcaatg ctcacgctgt   6900

aggtatctca gttcggtgta ggtcgttcgc tccaagctgg gctgtgtgca cgaacccccc   6960

gttcagcccg accgctgcgc cttatccggt aactatcgtc ttgagtccaa cccggtaaga   7020

cacgacttat cgccactggc agcagccact ggtaacagga ttagcagagc gaggtatgta   7080

ggcggtgcta cagagttctt gaagtggtgg cctaactacg gctacactag aaggacagta   7140

tttggtatct gcgctctgct gaagccagtt accttcggaa aaagagttgg tagctcttga   7200

tccggcaaac aaaccaccgc tggtagcggt ggtttttttg tttgcaagca gcagattacg   7260

cgcagaaaaa aaggatctca agaagatcct ttgatctttt ctacggggtc tgacgctcag   7320

tggaacgaaa actcacgtta agggattttg gtcatgagat tatcaaaaag gatcttcacc   7380

tagatccttt taaattaaaa atgaagtttt aaatcaatct aaagtatata tgagtaaact   7440

tggtctgaca gttaccaatg cttaatcagt gaggcaccta tctcagcgat ctgtctattt   7500

cgttcatcca tagttgcctg actccccgtc gtgtagataa ctacgatacg ggagggctta   7560

ccatctggcc ccagtgctgc aatgataccg cgagacccac gctcaccggc tccagattta   7620

tcagcaataa accagccagc cggaagggcc gagcgcagaa gtggtcctgc aactttatcc   7680

gcctccatcc agtctattaa ttgttgccgg gaagctagag taagtagttc gccagttaat   7740

agtttgcgca acgttgttgc cattgctaca ggcatcgtgg tgtcacgctc gtcgtttggt   7800

atggcttcat tcagctccgg ttcccaacga tcaaggcgag ttacatgatc ccccatgttg   7860

tgcaaaaaag cggttagctc cttcggtcct ccgatcgttg tcagaagtaa gttggccgca   7920

gtgttatcac tcatggttat ggcagcactg cataattctc ttactgtcat gccatccgta   7980

agatgctttt ctgtgactgg tgagtactca accaagtcat tctgagaata gtgtatgcgg   8040

cgaccgagtt gctcttgccc ggcgtcaata cgggataata ccgcgccaca tagcagaact   8100

ttaaaagtgc tcatcattgg aaaacgttct tcggggcgaa aactctcaag gatcttaccg   8160

ctgttgagat ccagttcgat gtaacccact cgtgcaccca actgatcttc agcatctttt   8220

actttcacca gcgtttctgg gtgagcaaaa acaggaaggc aaaatgccgc aaaaaaggga   8280

ataagggcga cacggaaatg ttgaatactc atactcttcc tttttcaata ttattgaagc   8340

atttatcagg gttattgtct catgagcgga tacatatttg aatgtattta gaaaaataaa   8400

caaatagggg ttccgcgcac atttccccga aaagtgccac ctgacgtc                8448


<210>  13
<211>  84
<212>  RNA
<213>  Homo sapiens

<400>  13
ucucagucug uggcacucag ccuugagggc acuuucuggu gccagaauga aagugcuguc     60

auagcugagg uccaaugacu gagg                                            84


<210>  14
<211>  98
<212>  RNA
<213>  Homo sapiens

<400>  14
gguacuucuc agucuguggc acucagccuu gagggcacuu ucuggugcca gaaugaaagu     60

gcugucauag cugaggucca augacugagg cgagcacc                             98


<210>  15
<211>  73
<212>  RNA
<213>  Homo sapiens

<400>  15
acugaggucc ucaaaacuga ggggcauuuu cugugguuug aaaggaaagu gcacccaguu     60

uuggggaugu caa                                                        73


<210>  16
<211>  124
<212>  RNA
<213>  Homo sapiens

<400>  16
aacccuccuu gggaagugaa gcucaggcug ugauuucaag ccagggggcg uuuuucuaua     60

acuggaugaa aagcaccucc agagcuugaa gcucacaguu ugagagcaau cgucuaagga    120

aguu                                                                 124


<210>  17
<211>  87
<212>  RNA
<213>  Homo sapiens

<400>  17
ucuccugcug ugacccucaa gauggaagca guuucuguug ucugaaagga aagaaagugc     60

uuccuuuuug aggguuacug uuugaga                                         87


<210>  18
<211>  83
<212>  RNA
<213>  Homo sapiens

<400>  18
ucucaugcag ucauucucca aaagaaagca cuuucuguug ucugaaagca gagugccuuc     60

uuuuggagcg uuacuguuug aga                                             83


<210>  19
<211>  84
<212>  RNA
<213>  Homo sapiens

<400>  19
ucucaugcag ucauucucca aaagggagca cuuucuguuu gaaagaaaac aaagugccuc     60

cuuuuagagu guuacuguuu gaga                                            84


<210>  20
<211>  87
<212>  RNA
<213>  Homo sapiens

<400>  20
ucucaggcug ugacccucua aagggaagcg cuuucugugg ucagaaagaa aagcaagugc     60

uuccuuuuag aggguuaccg uuuggga                                         87


<210>  21
<211>  83
<212>  RNA
<213>  Homo sapiens

<400>  21
ucucaugcag ucauucucca aaagaaagca cuuucuguug ucugaaagca gagugccuuc     60

uuuuggagcg uuacuguuug aga                                             83


<210>  22
<211>  87
<212>  RNA
<213>  Homo sapiens

<400>  22
ucucagccug ugacccucua gagggaagcg cuuucuguug ucugaaagaa aagaaagugc     60

aucuuuuuag aggauuacag uuugaga                                         87


<210>  23
<211>  87
<212>  RNA
<213>  Homo sapiens

<400>  23
cucaagcuau gagucuacaa aggaaagcgc uuucuguugu cagaaagaag agaaagcgcu     60

ucccuuuuga ggguuacggu uugagaa                                         87


<210>  24
<211>  85
<212>  RNA
<213>  Homo sapiens

<400>  24
cucaggcugu gacccuccag agggaaguac uuucuguugu cugagagaaa agaaagugcu     60

ucccuuugga cuguuucggu uugag                                           85


<210>  25
<211>  83
<212>  RNA
<213>  Homo sapiens

<400>  25
ucaggcugug acccucuuga gggaagcacu uucuguuguc ugaaagaaga gaaagugcuu     60

ccuuuuagag gcuuacuguc uga                                             83


<210>  26
<211>  81
<212>  RNA
<213>  Homo sapiens

<400>  26
caugcuguga cccucuagag ggaagcgcuu ucuguugucu gaaagaaaag aaagugcauc     60

cuuuuagagg uuuacuguuu g                                               81


<210>  27
<211>  85
<212>  RNA
<213>  Homo sapiens

<400>  27
cucaagcugu gacucuccag agggaugcac uuucucuuau gugaaaaaaa agaaggcgcu     60

ucccuuuaga gcguuacggu uuggg                                           85


<210>  28
<211>  87
<212>  RNA
<213>  Homo sapiens

<400>  28
ucucaugcug ugacccucua gagggaagcg cuuucuguug ucugaaagaa aagaacgcgc     60

uucccuauag aggguuaccc uuugaga                                         87


<210>  29
<211>  87
<212>  RNA
<213>  Homo sapiens

<400>  29
ucucaugcug ugacccucua gagggaagca cuuucucuug ucuaaaagaa aagaaagcgc     60

uucucuuuag aggauuacuc uuugaga                                         87


<210>  30
<211>  61
<212>  RNA
<213>  Homo sapiens

<400>  30
cccucuacag ggaagcgcuu ucuguugucu gaaagaaaag aaagugcuuc cuuuuagagg     60

g                                                                     61


<210>  31
<211>  83
<212>  RNA
<213>  Homo sapiens

<400>  31
ucaugcugug gcccuccaga gggaagcgcu uucuguuguc ugaaagaaaa caaagcgcuc     60

cccuuuagag guuuacgguu uga                                             83


<210>  32
<211>  85
<212>  RNA
<213>  Homo sapiens

<400>  32
cucaggcugu gacccucuag agggaagcac uuucuguugc uugaaagaag agaaagcgcu     60

uccuuuuaga ggauuacucu uugag                                           85


<210>  33
<211>  87
<212>  RNA
<213>  Homo sapiens

<400>  33
ucucaggcug ucguccucua gagggaagca cuuucuguug ucugaaagaa aagaaagugc     60

uuccuuuuag aggguuaccg uuugaga                                         87


<210>  34
<211>  101
<212>  RNA
<213>  Homo sapiens

<400>  34
gcgagaagau cucaugcugu gacucucugg agggaagcac uuucuguugu cugaaagaaa     60

acaaagcgcu ucucuuuaga guguuacggu uugagaaaag c                        101


<210>  35
<211>  87
<212>  RNA
<213>  Homo sapiens

<400>  35
ucucaugcug ugacccuaca aagggaagca cuuucucuug uccaaaggaa aagaaggcgc     60

uucccuuugg aguguuacgg uuugaga                                         87


<210>  36
<211>  87
<212>  RNA
<213>  Homo sapiens

<400>  36
ucucaggcag ugacccucua gauggaagca cugucuguug uauaaaagaa aagaucgugc     60

aucccuuuag aguguuacug uuugaga                                         87


<210>  37
<211>  88
<212>  RNA
<213>  Homo sapiens

<400>  37
ucccaugcug ugacccucca aagggaagcg cuuucuguuu guuuucucuu aaacaaagug     60

ccucccuuua gaguguuacc guuuggga                                        88


<210>  38
<211>  87
<212>  RNA
<213>  Homo sapiens

<400>  38
ucucgggcug ugacucucca aagggaagaa uuuucucuug ucuaaaagaa aagaacgcac     60

uucccuuuag aguguuaccg ugugaga                                         87


<210>  39
<211>  87
<212>  RNA
<213>  Homo sapiens

<400>  39
ucucaagcug ugagucuaca aagggaagcc cuuucuguug ucuaaaagaa aagaaagugc     60

uucucuuugg uggguuacgg uuugaga                                         87


<210>  40
<211>  67
<212>  RNA
<213>  Homo sapiens

<400>  40
gugacccucu agauggaagc acugucuguu gucuaagaaa agaucgugca ucccuuuaga     60

guguuac                                                               67


<210>  41
<211>  90
<212>  RNA
<213>  Homo sapiens

<400>  41
ucccaugcug ugacccucua gaggaagcac uuucuguuug uugucugaga aaaaacaaag     60

ugcuucccuu uagaguguua ccguuuggga                                      90


<210>  42
<211>  85
<212>  RNA
<213>  Homo sapiens

<400>  42
ucucaugaug ugaccaucug gagguaagaa gcacuuugug uuuugugaaa gaaagugcuu     60

ccuuucagag gguuacucuu ugaga                                           85


<210>  43
<211>  65
<212>  RNA
<213>  Homo sapiens

<400>  43
gugacccucu agagggaagc acuuucuguu gaaagaaaag aacaugcauc cuuucagagg     60

guuac                                                                 65


<210>  44
<211>  88
<212>  RNA
<213>  Homo sapiens

<400>  44
ucucaggcug ugacccucua gagggaagcg cuuucuguug gcuaaaagaa aagaaagcgc     60

uucccuucag aguguuaacg cuuugaga                                        88


<210>  45
<211>  85
<212>  RNA
<213>  Homo sapiens

<400>  45
ucucaagcug ugacugcaaa gggaagcccu uucuguuguc ugaaagaaga gaaagcgcuu     60

cccuuugcug gauuacgguu ugaga                                           85


<210>  46
<211>  87
<212>  RNA
<213>  Homo sapiens

<400>  46
ucccaugcug ugacccucua gagggaagca cuuucuguug ucugaaagaa accaaagcgc     60

uucccuuugg agcguuacgg uuugaga                                         87


<210>  47
<211>  90
<212>  RNA
<213>  Homo sapiens

<400>  47
ucucaggcug ugaccaucug gagguaagaa gcacuuucug uuuugugaaa gaaaagaaag     60

ugcuuccuuu cagaggguua cucuuugaga                                      90


<210>  48
<211>  87
<212>  RNA
<213>  Homo sapiens

<400>  48
ucucaagcug ugggucugca aagggaagcc cuuucuguug ucuaaaagaa gagaaagcgc     60

uucccuuugc uggauuacgg uuugaga                                         87


<210>  49
<211>  95
<212>  RNA
<213>  Homo sapiens

<400>  49
gaagaucuca ggcagugacc cucuagaugg aagcacuguc uguugucuaa gaaaagaucg     60

ugcauccuuu uagaguguua cuguuugaga aaauc                                95


<210>  50
<211>  88
<212>  RNA
<213>  Homo sapiens

<400>  50
ucccaugcug ugacccucua gaggaagcac uuucuguuug uugucugaga aaaaacaaag     60

ugcuucccuu uagaguuacu guuuggga                                        88


<210>  51
<211>  87
<212>  RNA
<213>  Homo sapiens

<400>  51
ucucaggcug ugacccucca aagggaagaa cuuucuguug ucuaaaagaa aagaacgcac     60

uucccuuuag aguguuaccg ugugaga                                         87


<210>  52
<211>  87
<212>  RNA
<213>  Homo sapiens

<400>  52
ucucaggcug ugucccucua gagggaagcg cuuucuguug ucugaaagaa aagaaaaugg     60

uucccuuuag aguguuacgc uuugaga                                         87


<210>  53
<211>  85
<212>  RNA
<213>  Homo sapiens

<400>  53
cucaggcugu gacacucuag agggaagcgc uuucuguugu cugaaagaaa ggaaagugca     60

uccuuuuaga guguuacugu uugag                                           85


<210>  54
<211>  85
<212>  RNA
<213>  Homo sapiens

<400>  54
ucucaagcug ugacugcaaa gggaagcccu uucuguuguc uaaaagaaaa gaaagugcuu     60

cccuuuggug aauuacgguu ugaga                                           85


<210>  55
<211>  90
<212>  RNA
<213>  Homo sapiens

<400>  55
ucucaggcug ugaccuucuc gaggaaagaa gcacuuucug uugucugaaa gaaaagaaag     60

ugcuuccuuu cagaggguua cgguuugaga                                      90


<210>  56
<211>  87
<212>  RNA
<213>  Homo sapiens

<400>  56
cucaagcugu gagucuacaa aggaaagcgc uuucuguugu cugaaagaaa agaaaucgcu     60

ucccuuugga guguuacggu uugagaa                                         87


<210>  57
<211>  90
<212>  RNA
<213>  Homo sapiens

<400>  57
ucucagguug ugaccuucuc gaggaaagaa gcacuuucug uugucugaaa gaaaagaaag     60

ugcuuccuuu cagaggguua cgguuugaga                                      90


<210>  58
<211>  87
<212>  RNA
<213>  Homo sapiens

<400>  58
ucucaggcug ugucccucua cagggaagcg cuuucuguug ucugaaagaa aggaaagugc     60

auccuuuuag aguguuacug uuugaga                                         87


