                         SEQUENCE LISTING

<110>  INSERM TRANSFERT
 
<120>  Polypeptides and nucleic acids for treating ErbB2-dependent 
       cancer

<130>  BEX10P0832

<150>  EP 09305884
<151>  2009-09-23

<160>  22    

<170>  PatentIn version 3.4

<210>  1
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Pro Lys Pro Ile Asn Val Arg Val Thr Thr Met Asp Ala Glu Leu 
1               5                   10                  15      


Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln 
            20                  25                  30          


Val Val Lys Thr Ile Gly Leu Arg Glu Val Trp Tyr Phe Gly Leu His 
        35                  40                  45              


Tyr Val Asp Asn Lys Gly Phe Pro Thr Trp Leu Lys Leu Asp Lys Lys 
    50                  55                  60                  


Val Ser Ala Gln Glu Val Arg Lys Glu Asn Pro Leu Gln Phe Lys Phe 
65                  70                  75                  80  


Arg Ala Lys Phe Tyr Pro Glu Asp Val Ala Glu Glu Leu Ile Gln Asp 
                85                  90                  95      


Ile Thr Gln Lys Leu Phe Phe Leu Gln Val Lys Glu Gly Ile Leu Ser 
            100                 105                 110         


Asp Glu Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu Gly Ser Tyr 
        115                 120                 125             


Ala Val Gln Ala Lys Phe Gly Asp Tyr Asn Lys Glu Val His Lys Ser 
    130                 135                 140                 


Gly Tyr Leu Ser Ser Glu Arg Leu Ile Pro Gln Arg Val Met Asp Gln 
145                 150                 155                 160 


His Lys Leu Thr Arg Asp Gln Trp Glu Asp Arg Ile Gln Val Trp His 
                165                 170                 175     


Ala Glu His Arg Gly Met Leu Lys Asp Asn Ala Met Leu Glu Tyr Leu 
            180                 185                 190         


Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Ile Asn Tyr Phe Glu Ile 
        195                 200                 205             


Lys Asn Lys Lys Gly Thr Asp Leu Trp Leu Gly Val Asp Ala Leu Gly 
    210                 215                 220                 


Leu Asn Ile Tyr Glu Lys Asp Asp Lys Leu Thr Pro Lys Ile Gly Phe 
225                 230                 235                 240 


Pro Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val 
                245                 250                 255     


Ile Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro 
            260                 265                 270         


Arg Leu Arg Ile Asn Lys Arg Ile Leu Gln Leu Cys Met Gly Asn His 
        275                 280                 285             


Glu Leu Tyr Met Arg Arg Arg 
    290                 295 


<210>  2
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Pro Lys Thr Ile Ser Val Arg Val Thr Thr Met Asp Ala Glu Leu 
1               5                   10                  15      


Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln 
            20                  25                  30          


Val Val Lys Thr Ile Gly Leu Arg Glu Val Trp Phe Phe Gly Leu Gln 
        35                  40                  45              


Tyr Gln Asp Thr Lys Gly Phe Ser Thr Trp Leu Lys Leu Asn Lys Lys 
    50                  55                  60                  


Val Thr Ala Gln Asp Val Arg Lys Glu Ser Pro Leu Leu Phe Lys Phe 
65                  70                  75                  80  


Arg Ala Lys Phe Tyr Pro Glu Asp Val Ser Glu Glu Leu Ile Gln Asp 
                85                  90                  95      


Ile Thr Gln Arg Leu Phe Phe Leu Gln Val Lys Glu Gly Ile Leu Asn 
            100                 105                 110         


Asp Asp Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu Ala Ser Tyr 
        115                 120                 125             


Ala Val Gln Ser Lys Tyr Gly Asp Phe Asn Lys Glu Val His Lys Ser 
    130                 135                 140                 


Gly Tyr Leu Ala Gly Asp Lys Leu Leu Pro Gln Arg Val Leu Glu Gln 
145                 150                 155                 160 


His Lys Leu Asn Lys Asp Gln Trp Glu Glu Arg Ile Gln Val Trp His 
                165                 170                 175     


Glu Glu His Arg Gly Met Leu Arg Glu Asp Ala Val Leu Glu Tyr Leu 
            180                 185                 190         


Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Ser Ile 
        195                 200                 205             


Lys Asn Lys Lys Gly Ser Glu Leu Trp Leu Gly Val Asp Ala Leu Gly 
    210                 215                 220                 


Leu Asn Ile Tyr Glu Gln Asn Asp Arg Leu Thr Pro Lys Ile Gly Phe 
225                 230                 235                 240 


Pro Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val 
                245                 250                 255     


Ile Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro 
            260                 265                 270         


Arg Leu Arg Ile Asn Lys Arg Ile Leu Ala Leu Cys Met Gly Asn His 
        275                 280                 285             


Glu Leu Tyr Met Arg Arg Arg 
    290                 295 


<210>  3
<211>  295
<212>  PRT
<213>  Homo sapiens

<400>  3

Met Pro Lys Pro Ile Asn Val Arg Val Thr Thr Met Asp Ala Glu Leu 
1               5                   10                  15      


Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln 
            20                  25                  30          


Val Val Lys Thr Val Gly Leu Arg Glu Val Trp Phe Phe Gly Leu Gln 
        35                  40                  45              


Tyr Val Asp Ser Lys Gly Tyr Ser Thr Trp Leu Lys Leu Asn Lys Lys 
    50                  55                  60                  


Val Thr Gln Gln Asp Val Lys Lys Glu Asn Pro Leu Gln Phe Lys Phe 
65                  70                  75                  80  


Arg Ala Lys Phe Phe Pro Glu Asp Val Ser Glu Glu Leu Ile Gln Glu 
                85                  90                  95      


Ile Thr Gln Arg Leu Phe Phe Leu Gln Val Lys Glu Ala Ile Leu Asn 
            100                 105                 110         


Asp Glu Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu Ala Ser Tyr 
        115                 120                 125             


Ala Val Gln Ala Lys Tyr Gly Asp Tyr Asn Lys Glu Ile His Lys Pro 
    130                 135                 140                 


Gly Tyr Leu Ala Asn Asp Arg Leu Leu Pro Gln Arg Val Leu Glu Gln 
145                 150                 155                 160 


His Lys Leu Thr Lys Glu Gln Trp Glu Glu Arg Ile Gln Asn Trp His 
                165                 170                 175     


Glu Glu His Arg Gly Met Leu Arg Glu Asp Ser Met Met Glu Tyr Leu 
            180                 185                 190         


Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Glu Ile 
        195                 200                 205             


Lys Asn Lys Lys Gly Thr Glu Leu Trp Leu Gly Val Asp Ala Leu Gly 
    210                 215                 220                 


Leu Asn Ile Tyr Glu His Asp Asp Lys Leu Thr Pro Lys Ile Gly Phe 
225                 230                 235                 240 


Pro Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val 
                245                 250                 255     


Ile Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro 
            260                 265                 270         


Arg Leu Arg Ile Asn Lys Arg Ile Leu Ala Leu Cys Met Gly Asn His 
        275                 280                 285             


Glu Leu Tyr Met Arg Arg Arg 
    290                 295 


<210>  4
<211>  291
<212>  PRT
<213>  Homo sapiens

<400>  4

Thr Phe Thr Val Arg Ile Val Thr Met Asp Ala Glu Met Glu Phe Asn 
1               5                   10                  15      


Cys Glu Met Lys Trp Lys Gly Lys Asp Leu Phe Asp Leu Val Cys Arg 
            20                  25                  30          


Thr Leu Gly Leu Arg Glu Thr Trp Phe Phe Gly Leu Gln Tyr Thr Ile 
        35                  40                  45              


Lys Asp Thr Val Ala Trp Leu Lys Met Asp Lys Lys Val Leu Asp His 
    50                  55                  60                  


Asp Val Ser Lys Glu Glu Pro Val Thr Phe His Phe Leu Ala Lys Phe 
65                  70                  75                  80  


Tyr Pro Glu Asn Ala Glu Glu Glu Leu Val Gln Glu Ile Thr Gln His 
                85                  90                  95      


Leu Phe Phe Leu Gln Val Lys Lys Gln Ile Leu Asp Glu Lys Ile Tyr 
            100                 105                 110         


Cys Pro Pro Glu Ala Ser Val Leu Leu Ala Ser Tyr Ala Val Gln Ala 
        115                 120                 125             


Lys Tyr Gly Asp Tyr Asp Pro Ser Val His Lys Arg Gly Phe Leu Ala 
    130                 135                 140                 


Gln Glu Glu Leu Leu Pro Lys Arg Val Ile Asn Leu Tyr Gln Met Thr 
145                 150                 155                 160 


Pro Glu Met Trp Glu Glu Arg Ile Thr Ala Trp Tyr Ala Glu His Arg 
                165                 170                 175     


Gly Arg Ala Arg Asp Glu Ala Glu Met Glu Tyr Leu Lys Ile Ala Gln 
            180                 185                 190         


Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Ala Ile Arg Asn Lys Lys 
        195                 200                 205             


Gly Thr Glu Leu Leu Leu Gly Val Asp Ala Leu Gly Leu His Ile Tyr 
    210                 215                 220                 


Asp Pro Glu Asn Arg Leu Thr Pro Lys Ile Ser Phe Pro Trp Asn Glu 
225                 230                 235                 240 


Ile Arg Asn Ile Ser Tyr Ser Asp Lys Glu Phe Thr Ile Lys Pro Leu 
                245                 250                 255     


Asp Lys Lys Ile Asp Val Phe Lys Phe Asn Ser Ser Lys Leu Arg Val 
            260                 265                 270         


Asn Lys Leu Ile Leu Gln Leu Cys Ile Gly Asn His Asp Leu Phe Met 
        275                 280                 285             


Arg Arg Arg 
    290     


<210>  5
<211>  586
<212>  PRT
<213>  Homo sapiens

<400>  5

Met Pro Lys Pro Ile Asn Val Arg Val Thr Thr Met Asp Ala Glu Leu 
1               5                   10                  15      


Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln 
            20                  25                  30          


Val Val Lys Thr Ile Gly Leu Arg Glu Val Trp Tyr Phe Gly Leu His 
        35                  40                  45              


Tyr Val Asp Asn Lys Gly Phe Pro Thr Trp Leu Lys Leu Asp Lys Lys 
    50                  55                  60                  


Val Ser Ala Gln Glu Val Arg Lys Glu Asn Pro Leu Gln Phe Lys Phe 
65                  70                  75                  80  


Arg Ala Lys Phe Tyr Pro Glu Asp Val Ala Glu Glu Leu Ile Gln Asp 
                85                  90                  95      


Ile Thr Gln Lys Leu Phe Phe Leu Gln Val Lys Glu Gly Ile Leu Ser 
            100                 105                 110         


Asp Glu Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu Gly Ser Tyr 
        115                 120                 125             


Ala Val Gln Ala Lys Phe Gly Asp Tyr Asn Lys Glu Val His Lys Ser 
    130                 135                 140                 


Gly Tyr Leu Ser Ser Glu Arg Leu Ile Pro Gln Arg Val Met Asp Gln 
145                 150                 155                 160 


His Lys Leu Thr Arg Asp Gln Trp Glu Asp Arg Ile Gln Val Trp His 
                165                 170                 175     


Ala Glu His Arg Gly Met Leu Lys Asp Asn Ala Met Leu Glu Tyr Leu 
            180                 185                 190         


Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Ile Asn Tyr Phe Glu Ile 
        195                 200                 205             


Lys Asn Lys Lys Gly Thr Asp Leu Trp Leu Gly Val Asp Ala Leu Gly 
    210                 215                 220                 


Leu Asn Ile Tyr Glu Lys Asp Asp Lys Leu Thr Pro Lys Ile Gly Phe 
225                 230                 235                 240 


Pro Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val 
                245                 250                 255     


Ile Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro 
            260                 265                 270         


Arg Leu Arg Ile Asn Lys Arg Ile Leu Gln Leu Cys Met Gly Asn His 
        275                 280                 285             


Glu Leu Tyr Met Arg Arg Arg Lys Pro Asp Thr Ile Glu Val Gln Gln 
    290                 295                 300                 


Met Lys Ala Gln Ala Arg Glu Glu Lys His Gln Lys Gln Leu Glu Arg 
305                 310                 315                 320 


Gln Gln Leu Glu Thr Glu Lys Lys Arg Arg Glu Thr Val Glu Arg Glu 
                325                 330                 335     


Lys Glu Gln Met Met Arg Glu Lys Glu Glu Leu Met Leu Arg Leu Gln 
            340                 345                 350         


Asp Tyr Glu Glu Lys Thr Lys Lys Ala Glu Arg Glu Leu Ser Glu Gln 
        355                 360                 365             


Ile Gln Arg Ala Leu Gln Leu Glu Glu Glu Arg Lys Arg Ala Gln Glu 
    370                 375                 380                 


Glu Ala Glu Arg Leu Glu Ala Asp Arg Met Ala Ala Leu Arg Ala Lys 
385                 390                 395                 400 


Glu Glu Leu Glu Arg Gln Ala Val Asp Gln Ile Lys Ser Gln Glu Gln 
                405                 410                 415     


Leu Ala Ala Glu Leu Ala Glu Tyr Thr Ala Lys Ile Ala Leu Leu Glu 
            420                 425                 430         


Glu Ala Arg Arg Arg Lys Glu Asp Glu Val Glu Glu Trp Gln His Arg 
        435                 440                 445             


Ala Lys Glu Ala Gln Asp Asp Leu Val Lys Thr Lys Glu Glu Leu His 
    450                 455                 460                 


Leu Val Met Thr Ala Pro Pro Pro Pro Pro Pro Pro Val Tyr Glu Pro 
465                 470                 475                 480 


Val Ser Tyr His Val Gln Glu Ser Leu Gln Asp Glu Gly Ala Glu Pro 
                485                 490                 495     


Thr Gly Tyr Ser Ala Glu Leu Ser Ser Glu Gly Ile Arg Asp Asp Arg 
            500                 505                 510         


Asn Glu Glu Lys Arg Ile Thr Glu Ala Glu Lys Asn Glu Arg Val Gln 
        515                 520                 525             


Arg Gln Leu Leu Thr Leu Ser Ser Glu Leu Ser Gln Ala Arg Asp Glu 
    530                 535                 540                 


Asn Lys Arg Thr His Asn Asp Ile Ile His Asn Glu Asn Met Arg Gln 
545                 550                 555                 560 


Gly Arg Asp Lys Tyr Lys Thr Leu Arg Gln Ile Arg Gln Gly Asn Thr 
                565                 570                 575     


Lys Gln Arg Ile Asp Glu Phe Glu Ala Leu 
            580                 585     


<210>  6
<211>  577
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Pro Lys Thr Ile Ser Val Arg Val Thr Thr Met Asp Ala Glu Leu 
1               5                   10                  15      


Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln 
            20                  25                  30          


Val Val Lys Thr Ile Gly Leu Arg Glu Val Trp Phe Phe Gly Leu Gln 
        35                  40                  45              


Tyr Gln Asp Thr Lys Gly Phe Ser Thr Trp Leu Lys Leu Asn Lys Lys 
    50                  55                  60                  


Val Thr Ala Gln Asp Val Arg Lys Glu Ser Pro Leu Leu Phe Lys Phe 
65                  70                  75                  80  


Arg Ala Lys Phe Tyr Pro Glu Asp Val Ser Glu Glu Leu Ile Gln Asp 
                85                  90                  95      


Ile Thr Gln Arg Leu Phe Phe Leu Gln Val Lys Glu Gly Ile Leu Asn 
            100                 105                 110         


Asp Asp Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu Ala Ser Tyr 
        115                 120                 125             


Ala Val Gln Ser Lys Tyr Gly Asp Phe Asn Lys Glu Val His Lys Ser 
    130                 135                 140                 


Gly Tyr Leu Ala Gly Asp Lys Leu Leu Pro Gln Arg Val Leu Glu Gln 
145                 150                 155                 160 


His Lys Leu Asn Lys Asp Gln Trp Glu Glu Arg Ile Gln Val Trp His 
                165                 170                 175     


Glu Glu His Arg Gly Met Leu Arg Glu Asp Ala Val Leu Glu Tyr Leu 
            180                 185                 190         


Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Ser Ile 
        195                 200                 205             


Lys Asn Lys Lys Gly Ser Glu Leu Trp Leu Gly Val Asp Ala Leu Gly 
    210                 215                 220                 


Leu Asn Ile Tyr Glu Gln Asn Asp Arg Leu Thr Pro Lys Ile Gly Phe 
225                 230                 235                 240 


Pro Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val 
                245                 250                 255     


Ile Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro 
            260                 265                 270         


Arg Leu Arg Ile Asn Lys Arg Ile Leu Ala Leu Cys Met Gly Asn His 
        275                 280                 285             


Glu Leu Tyr Met Arg Arg Arg Lys Pro Asp Thr Ile Glu Val Gln Gln 
    290                 295                 300                 


Met Lys Ala Gln Ala Arg Glu Glu Lys His Gln Lys Gln Met Glu Arg 
305                 310                 315                 320 


Ala Met Leu Glu Asn Glu Lys Lys Lys Arg Glu Met Ala Glu Lys Glu 
                325                 330                 335     


Lys Glu Lys Ile Glu Arg Glu Lys Glu Glu Leu Met Glu Arg Leu Lys 
            340                 345                 350         


Gln Ile Glu Glu Gln Thr Lys Lys Ala Gln Gln Glu Leu Glu Glu Gln 
        355                 360                 365             


Thr Arg Arg Ala Leu Glu Leu Glu Gln Glu Arg Lys Arg Ala Gln Ser 
    370                 375                 380                 


Glu Ala Glu Lys Leu Ala Lys Glu Arg Gln Glu Ala Glu Glu Ala Lys 
385                 390                 395                 400 


Glu Ala Leu Leu Gln Ala Ser Arg Asp Gln Lys Lys Thr Gln Glu Gln 
                405                 410                 415     


Leu Ala Leu Glu Met Ala Glu Leu Thr Ala Arg Ile Ser Gln Leu Glu 
            420                 425                 430         


Met Ala Arg Gln Lys Lys Glu Ser Glu Ala Val Glu Trp Gln Gln Lys 
        435                 440                 445             


Ala Gln Met Val Gln Glu Asp Leu Glu Lys Thr Arg Ala Glu Leu Lys 
    450                 455                 460                 


Thr Ala Met Ser Thr Pro His Val Ala Glu Pro Ala Glu Asn Glu Gln 
465                 470                 475                 480 


Asp Glu Gln Asp Glu Asn Gly Ala Glu Ala Ser Ala Asp Leu Arg Ala 
                485                 490                 495     


Asp Ala Met Ala Lys Asp Arg Ser Glu Glu Glu Arg Thr Thr Glu Ala 
            500                 505                 510         


Glu Lys Asn Glu Arg Val Gln Lys His Leu Lys Ala Leu Thr Ser Glu 
        515                 520                 525             


Leu Ala Asn Ala Arg Asp Glu Ser Lys Lys Thr Ala Asn Asp Met Ile 
    530                 535                 540                 


His Ala Glu Asn Met Arg Leu Gly Arg Asp Lys Tyr Lys Thr Leu Arg 
545                 550                 555                 560 


Gln Ile Arg Gln Gly Asn Thr Lys Gln Arg Ile Asp Glu Phe Glu Ser 
                565                 570                 575     


Met 
    


<210>  7
<211>  583
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Pro Lys Pro Ile Asn Val Arg Val Thr Thr Met Asp Ala Glu Leu 
1               5                   10                  15      


Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln 
            20                  25                  30          


Val Val Lys Thr Val Gly Leu Arg Glu Val Trp Phe Phe Gly Leu Gln 
        35                  40                  45              


Tyr Val Asp Ser Lys Gly Tyr Ser Thr Trp Leu Lys Leu Asn Lys Lys 
    50                  55                  60                  


Val Thr Gln Gln Asp Val Lys Lys Glu Asn Pro Leu Gln Phe Lys Phe 
65                  70                  75                  80  


Arg Ala Lys Phe Phe Pro Glu Asp Val Ser Glu Glu Leu Ile Gln Glu 
                85                  90                  95      


Ile Thr Gln Arg Leu Phe Phe Leu Gln Val Lys Glu Ala Ile Leu Asn 
            100                 105                 110         


Asp Glu Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu Ala Ser Tyr 
        115                 120                 125             


Ala Val Gln Ala Lys Tyr Gly Asp Tyr Asn Lys Glu Ile His Lys Pro 
    130                 135                 140                 


Gly Tyr Leu Ala Asn Asp Arg Leu Leu Pro Gln Arg Val Leu Glu Gln 
145                 150                 155                 160 


His Lys Leu Thr Lys Glu Gln Trp Glu Glu Arg Ile Gln Asn Trp His 
                165                 170                 175     


Glu Glu His Arg Gly Met Leu Arg Glu Asp Ser Met Met Glu Tyr Leu 
            180                 185                 190         


Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Glu Ile 
        195                 200                 205             


Lys Asn Lys Lys Gly Thr Glu Leu Trp Leu Gly Val Asp Ala Leu Gly 
    210                 215                 220                 


Leu Asn Ile Tyr Glu His Asp Asp Lys Leu Thr Pro Lys Ile Gly Phe 
225                 230                 235                 240 


Pro Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val 
                245                 250                 255     


Ile Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro 
            260                 265                 270         


Arg Leu Arg Ile Asn Lys Arg Ile Leu Ala Leu Cys Met Gly Asn His 
        275                 280                 285             


Glu Leu Tyr Met Arg Arg Arg Lys Pro Asp Thr Ile Glu Val Gln Gln 
    290                 295                 300                 


Met Lys Ala Gln Ala Arg Glu Glu Lys His Gln Lys Gln Leu Glu Arg 
305                 310                 315                 320 


Ala Gln Leu Glu Asn Glu Lys Lys Lys Arg Glu Ile Ala Glu Lys Glu 
                325                 330                 335     


Lys Glu Arg Ile Glu Arg Glu Lys Glu Glu Leu Met Glu Arg Leu Lys 
            340                 345                 350         


Gln Ile Glu Glu Gln Thr Ile Lys Ala Gln Lys Glu Leu Glu Glu Gln 
        355                 360                 365             


Thr Arg Lys Ala Leu Glu Leu Asp Gln Glu Arg Lys Arg Ala Lys Glu 
    370                 375                 380                 


Glu Ala Glu Arg Leu Glu Lys Glu Arg Arg Ala Ala Glu Glu Ala Lys 
385                 390                 395                 400 


Ser Ala Ile Ala Lys Gln Ala Ala Asp Gln Met Lys Asn Gln Glu Gln 
                405                 410                 415     


Leu Ala Ala Glu Leu Ala Glu Phe Thr Ala Lys Ile Ala Leu Leu Glu 
            420                 425                 430         


Glu Ala Lys Lys Lys Lys Glu Glu Glu Ala Thr Glu Trp Gln His Lys 
        435                 440                 445             


Ala Phe Ala Ala Gln Glu Asp Leu Glu Lys Thr Lys Glu Glu Leu Lys 
    450                 455                 460                 


Thr Val Met Ser Ala Pro Pro Pro Pro Pro Pro Pro Pro Val Ile Pro 
465                 470                 475                 480 


Pro Thr Glu Asn Glu His Asp Glu His Asp Glu Asn Asn Ala Glu Ala 
                485                 490                 495     


Ser Ala Glu Leu Ser Asn Glu Gly Val Met Asn His Arg Ser Glu Glu 
            500                 505                 510         


Glu Arg Val Thr Glu Thr Gln Lys Asn Glu Arg Val Lys Lys Gln Leu 
        515                 520                 525             


Gln Ala Leu Ser Ser Glu Leu Ala Gln Ala Arg Asp Glu Thr Lys Lys 
    530                 535                 540                 


Thr Gln Asn Asp Val Leu His Ala Glu Asn Val Lys Ala Gly Arg Asp 
545                 550                 555                 560 


Lys Tyr Lys Thr Leu Arg Gln Ile Arg Gln Gly Asn Thr Lys Gln Arg 
                565                 570                 575     


Ile Asp Glu Phe Glu Ala Met 
            580             


<210>  8
<211>  595
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Gly Ala Ile Ala Ser Arg Met Ser Phe Ser Ser Leu Lys Arg 
1               5                   10                  15      


Lys Gln Pro Lys Thr Phe Thr Val Arg Ile Val Thr Met Asp Ala Glu 
            20                  25                  30          


Met Glu Phe Asn Cys Glu Met Lys Trp Lys Gly Lys Asp Leu Phe Asp 
        35                  40                  45              


Leu Val Cys Arg Thr Leu Gly Leu Arg Glu Thr Trp Phe Phe Gly Leu 
    50                  55                  60                  


Gln Tyr Thr Ile Lys Asp Thr Val Ala Trp Leu Lys Met Asp Lys Lys 
65                  70                  75                  80  


Val Leu Asp His Asp Val Ser Lys Glu Glu Pro Val Thr Phe His Phe 
                85                  90                  95      


Leu Ala Lys Phe Tyr Pro Glu Asn Ala Glu Glu Glu Leu Val Gln Glu 
            100                 105                 110         


Ile Thr Gln His Leu Phe Phe Leu Gln Val Lys Lys Gln Ile Leu Asp 
        115                 120                 125             


Glu Lys Ile Tyr Cys Pro Pro Glu Ala Ser Val Leu Leu Ala Ser Tyr 
    130                 135                 140                 


Ala Val Gln Ala Lys Tyr Gly Asp Tyr Asp Pro Ser Val His Lys Arg 
145                 150                 155                 160 


Gly Phe Leu Ala Gln Glu Glu Leu Leu Pro Lys Arg Val Ile Asn Leu 
                165                 170                 175     


Tyr Gln Met Thr Pro Glu Met Trp Glu Glu Arg Ile Thr Ala Trp Tyr 
            180                 185                 190         


Ala Glu His Arg Gly Arg Ala Arg Asp Glu Ala Glu Met Glu Tyr Leu 
        195                 200                 205             


Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Ala Ile 
    210                 215                 220                 


Arg Asn Lys Lys Gly Thr Glu Leu Leu Leu Gly Val Asp Ala Leu Gly 
225                 230                 235                 240 


Leu His Ile Tyr Asp Pro Glu Asn Arg Leu Thr Pro Lys Ile Ser Phe 
                245                 250                 255     


Pro Trp Asn Glu Ile Arg Asn Ile Ser Tyr Ser Asp Lys Glu Phe Thr 
            260                 265                 270         


Ile Lys Pro Leu Asp Lys Lys Ile Asp Val Phe Lys Phe Asn Ser Ser 
        275                 280                 285             


Lys Leu Arg Val Asn Lys Leu Ile Leu Gln Leu Cys Ile Gly Asn His 
    290                 295                 300                 


Asp Leu Phe Met Arg Arg Arg Lys Ala Asp Ser Leu Glu Val Gln Gln 
305                 310                 315                 320 


Met Lys Ala Gln Ala Arg Glu Glu Lys Ala Arg Lys Gln Met Glu Arg 
                325                 330                 335     


Gln Arg Leu Ala Arg Glu Lys Gln Met Arg Glu Glu Ala Glu Arg Thr 
            340                 345                 350         


Arg Asp Glu Leu Glu Arg Arg Leu Leu Gln Met Lys Glu Glu Ala Thr 
        355                 360                 365             


Met Ala Asn Glu Ala Leu Met Arg Ser Glu Glu Thr Ala Asp Leu Leu 
    370                 375                 380                 


Ala Glu Lys Ala Gln Ile Thr Glu Glu Glu Ala Lys Leu Leu Ala Gln 
385                 390                 395                 400 


Lys Ala Ala Glu Ala Glu Gln Glu Met Gln Arg Ile Lys Ala Thr Ala 
                405                 410                 415     


Ile Arg Thr Glu Glu Glu Lys Arg Leu Met Glu Gln Lys Val Leu Glu 
            420                 425                 430         


Ala Glu Val Leu Ala Leu Lys Met Ala Glu Glu Ser Glu Arg Arg Ala 
        435                 440                 445             


Lys Glu Ala Asp Gln Leu Lys Gln Asp Leu Gln Glu Ala Arg Glu Ala 
    450                 455                 460                 


Glu Arg Arg Ala Lys Gln Lys Leu Leu Glu Ile Ala Thr Lys Pro Thr 
465                 470                 475                 480 


Tyr Pro Pro Met Asn Pro Ile Pro Ala Pro Leu Pro Pro Asp Ile Pro 
                485                 490                 495     


Ser Phe Asn Leu Ile Gly Asp Ser Leu Ser Phe Asp Phe Lys Asp Thr 
            500                 505                 510         


Asp Met Lys Arg Leu Ser Met Glu Ile Glu Lys Glu Lys Val Glu Tyr 
        515                 520                 525             


Met Glu Lys Ser Lys His Leu Gln Glu Gln Leu Asn Glu Leu Lys Thr 
    530                 535                 540                 


Glu Ile Glu Ala Leu Lys Leu Lys Glu Arg Glu Thr Ala Leu Asp Ile 
545                 550                 555                 560 


Leu His Asn Glu Asn Ser Asp Arg Gly Gly Ser Ser Lys His Asn Thr 
                565                 570                 575     


Ile Lys Lys Leu Thr Leu Gln Ser Ala Lys Ser Arg Val Ala Phe Phe 
            580                 585                 590         


Glu Glu Leu 
        595 


<210>  9
<211>  22
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptide

<400>  9

Leu Gly Ala Ser Trp His Ala Arg Pro Asp Lys Cys Cys Leu Gly Tyr 
1               5                   10                  15      


Gln Lys Arg Pro Leu Pro 
            20          


<210>  10
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  peptide

<400>  10

Leu Gly Ala Ser Trp His Ala Arg Pro Asp Lys 
1               5                   10      


<210>  11
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Flag tag

<400>  11

Asp Tyr Lys Asp Asp Asp Asp Lys 
1               5               


<210>  12
<211>  135
<212>  DNA
<213>  artificial sequence

<220>
<223>  Epstein-Barr virus Zebra protein transduction domain MD11

<400>  12
aagcgataca agaatcgggt ggcttccaga aaatgccggg ccaagtttaa gcaactgctg     60

cagcactacc gtgaggtcgc tgctgccaaa tcatctgaaa atgacaggct gcgcctcctg    120

ttgaagcaga tgtgc                                                     135


<210>  13
<211>  45
<212>  PRT
<213>  artificial sequence

<220>
<223>  Epstein-Barr virus Zebra protein transduction domain MD11

<400>  13

Lys Arg Tyr Lys Asn Arg Val Ala Ser Arg Lys Cys Arg Ala Lys Phe 
1               5                   10                  15      


Lys Gln Leu Leu Gln His Tyr Arg Glu Val Ala Ala Ala Lys Ser Ser 
            20                  25                  30          


Glu Asn Asp Arg Leu Arg Leu Leu Leu Lys Gln Met Cys 
        35                  40                  45  


<210>  14
<211>  60
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  14
ggaattccat atgcatcatc atcatcatca tcatcacaag cgatacaaga atcgggtggc     60


<210>  15
<211>  35
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  15
ggaattccat atgccgaaac caatcaatgt ccgag                                35


<210>  16
<211>  28
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  16
cccaagcttg cacatctgct tcaacagg                                        28


<210>  17
<211>  31
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  17
cccaagctta tgccgaaacc aatcaatgtc c                                    31


<210>  18
<211>  33
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  18
ccgctcgagt tacttgtaca gctcgtccat gcc                                  33


<210>  19
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  19
ccgctcgagt taccgctcca gctgcttctg                                      30


<210>  20
<211>  27
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  20
cccaagcttc cgctccagct gcttctg                                         27


<210>  21
<211>  32
<212>  DNA
<213>  artificial sequence

<220>
<223>  primer

<400>  21
cccaagctta agcgatacaa gaatcgggtg gc                                   32


<210>  22
<211>  28
<212>  DNA
<213>  artificial sequence 

<220>
<223>  primer

<400>  22
ccgctcgagg cacatctgct tcaacagg                                        28


