                         SEQUENCE LISTING

<110>  INSERM
 
<120>  MODIFIED GRAM-NEGATIVE BACTERIA FOR USE AS VACCINES

<130>  BEP090056

<160>  28    

<170>  PatentIn version 3.3

<210>  1
<211>  354
<212>  PRT
<213>  Brucella abortus

<400>  1

Met Thr Leu Ser Gly Gln Val Pro Val Arg Glu Val Glu Val Val Ala 
1               5                   10                  15      


Pro Asn Phe Lys Arg Arg Leu Ser Gly Val Thr Ser Thr Ile Val Gln 
            20                  25                  30          


Leu Ile Pro Leu Gln Arg Ala Met Gly Leu Lys Ile Ala Thr Met Gly 
        35                  40                  45              


Pro Gly Leu Pro Asp Thr Leu Pro His Leu Gly Trp Ser Ala Leu Pro 
    50                  55                  60                  


Ser Phe Trp Ser Arg Pro Lys Thr Arg Arg Phe Arg Ile Trp His Ala 
65                  70                  75                  80  


Arg Arg Asn Ile Glu Met Leu Ala Gly Ile Phe Met Arg Asp Val Leu 
                85                  90                  95      


Arg Met Lys Leu Arg Leu Val Phe Thr Ser Ala Ala Gln Arg His His 
            100                 105                 110         


Lys Pro Phe Thr Lys Trp Leu Ile Arg Arg Met Asn Ala Val Ile Ala 
        115                 120                 125             


Thr Ser Val Arg Ser Gly Ser Phe Leu Glu Val Pro His Gln Val Ile 
    130                 135                 140                 


Met His Gly Val Asp Leu Glu Arg Phe His Pro Pro Leu Ala Glu Asp 
145                 150                 155                 160 


Asp Asp Phe Ser Ala Ser Gly Leu Pro Gly Lys Tyr Ala Val Gly Cys 
                165                 170                 175     


Phe Gly Arg Val Arg Pro Ser Lys Gly Thr Asp Leu Phe Val Asp Ala 
            180                 185                 190         


Met Ile Ala Leu Leu Pro Lys Tyr Pro Asp Trp Thr Ala Ile Val Thr 
        195                 200                 205             


Gly Arg Thr Thr Ala Glu Tyr Gln Ala Phe Glu Ala Glu Leu Arg Thr 
    210                 215                 220                 


Arg Ile Ala Ala Ala Gly Leu Gln Asp Arg Ile Leu Ile Leu Gly Glu 
225                 230                 235                 240 


Val Pro Asp Val Arg Val Trp Tyr Arg Arg Leu Thr Leu Tyr Val Ala 
                245                 250                 255     


Pro Ser Arg Asn Glu Gly Phe Gly Leu Thr Pro Leu Glu Ala Met Ala 
            260                 265                 270         


Ser Lys Thr Ala Val Val Ala Ser Asp Ala Gly Ala Tyr Ala Glu Met 
        275                 280                 285             


Val Val Glu Asp Thr Gly Arg Phe Val Pro Ala Gly Asp Gly Arg Ala 
    290                 295                 300                 


Leu Thr Asn Ala Ile Glu Pro Tyr Leu Ala Asp Pro Ala Met Thr Lys 
305                 310                 315                 320 


Arg Cys Gly Glu Asn Ala Leu Ala His Val Arg Glu Ala Phe Pro Leu 
                325                 330                 335     


Gln Lys Glu Ala Ala Ala Ile Ser Ser Val Tyr Glu Gln Val Phe Ala 
            340                 345                 350         


Gly Arg 
        


<210>  2
<211>  352
<212>  PRT
<213>  Bartonella quintana

<400>  2

Met Arg Met Ser Leu Lys Glu Thr Glu Val Ile Ala Pro His Phe Lys 
1               5                   10                  15      


Lys Arg Leu Ser Gly Val Thr Ser Thr Val Ile Gln Leu Ile Pro Leu 
            20                  25                  30          


Gln Arg Lys Gln Gly Ile His Ile Ser Thr Leu Gly Phe Gly Leu Pro 
        35                  40                  45              


Lys Asn Leu Pro Ala Leu Ala Phe Lys Asp Leu Phe Glu Leu Trp Lys 
    50                  55                  60                  


Ser Pro Val Asp Lys Pro Phe Arg Ile Trp His Ala Arg Arg Asn Ile 
65                  70                  75                  80  


Glu Met Leu Cys Gly Val Phe Leu Arg Asp Ile Leu Arg Met Lys Leu 
                85                  90                  95      


Lys Leu Leu Phe Thr Ser Ala Ser Arg Arg His His Lys Pro Phe Thr 
            100                 105                 110         


Lys Trp Leu Ile Arg Arg Met Asp Lys Val Ile Ala Thr Ser Val Cys 
        115                 120                 125             


Thr Gly Thr Tyr Leu Glu Val Pro His Gln Val Val Met His Gly Val 
    130                 135                 140                 


Asp Val Arg Arg Phe Ser Pro Pro Lys Thr Leu Asp Asp Cys Phe Ser 
145                 150                 155                 160 


Ser Ser Asp Phe Pro Gly Lys Tyr Ala Val Gly Cys Phe Gly Arg Val 
                165                 170                 175     


Arg Tyr Leu Lys Gly Thr Asp Leu Phe Val Asn Ala Met Ile Ala Leu 
            180                 185                 190         


Leu Pro Arg Tyr Pro Glu Trp Thr Ala Leu Ile Ala Gly Arg Thr Thr 
        195                 200                 205             


Glu Gln His Tyr Asn Phe Glu Lys Lys Leu Arg Gln Lys Ile Ala Glu 
    210                 215                 220                 


Ala Glu Leu Asp Asn Arg Ile Ile Phe Leu Gly Glu Val Leu Asn Thr 
225                 230                 235                 240 


Pro Leu Trp Tyr Arg Arg Leu Ser Leu Tyr Val Thr Pro Ser Arg Leu 
                245                 250                 255     


Glu Gly Phe Gly Leu Thr Pro Leu Glu Ala Met Ala Ser Gln Thr Ala 
            260                 265                 270         


Val Val Thr Ser Asp Val Gly Ile Phe Lys Glu Leu Val Val Glu Gly 
        275                 280                 285             


Thr Gly Thr Val Val Gln Ala Gly Asp Gly Val Ala Leu Thr Glu Ala 
    290                 295                 300                 


Ile Glu Pro Tyr Phe Ala Asp Leu Glu Lys Thr Leu Val Ala Gly Glu 
305                 310                 315                 320 


Lys Ala Leu Ala His Val Arg Thr His Phe Pro Leu Glu Lys Glu Ala 
                325                 330                 335     


Ala Glu Ile Gly Ser Ile Tyr Glu Thr Met Phe Ser Glu Lys Thr Leu 
            340                 345                 350         


<210>  3
<211>  352
<212>  PRT
<213>  Bartonella tribocorum

<400>  3

Met Arg Val Ser Leu Glu Glu Thr Glu Ile Ile Ala Pro His Phe Lys 
1               5                   10                  15      


Arg Pro Leu Ser Gly Glu Thr Ser Thr Ile Val Gln Leu Val Pro Leu 
            20                  25                  30          


Met Arg Glu Gln Gly Val Arg Ile Ser Thr Leu Gly Val Gly Leu Pro 
        35                  40                  45              


Lys Lys Met Pro Ala Leu Ala Phe Arg Asp Leu Phe Gly Leu Trp Lys 
    50                  55                  60                  


Ser Pro Lys Gly Lys Ser Phe Arg Ile Trp His Ala Arg Arg Asn Ile 
65                  70                  75                  80  


Glu Met Leu Cys Gly Ile Phe Leu Arg Asp Ile Leu Lys Met Lys Leu 
                85                  90                  95      


Lys Leu Ile Phe Thr Ser Ala Ser Gln Arg His His Lys Pro Phe Thr 
            100                 105                 110         


Lys Trp Leu Ile Arg Arg Met Asp Arg Val Ile Ala Thr Ser Thr His 
        115                 120                 125             


Thr Gly Ala Tyr Leu Glu Val Pro His Lys Val Ile Met His Gly Val 
    130                 135                 140                 


Asp Val Arg Arg Phe Thr Pro Pro Gln Thr His Asp Asp Cys Phe Ala 
145                 150                 155                 160 


Ser Thr Gly Phe Pro Gly Lys Tyr Ala Val Gly Cys Phe Gly Arg Val 
                165                 170                 175     


Arg Tyr Leu Lys Gly Thr Asp Leu Phe Val Glu Ala Met Ile Ala Leu 
            180                 185                 190         


Leu Pro His Tyr Pro Glu Trp Thr Ala Leu Ile Ala Gly Arg Thr Thr 
        195                 200                 205             


Glu Gln His Tyr His Phe Glu Lys Glu Leu Arg Gln Lys Ile Ala Lys 
    210                 215                 220                 


Ala Gly Leu Asp Asp Arg Ile Ile Phe Leu Gly Glu Ile Leu Asp Ile 
225                 230                 235                 240 


Pro Leu Trp Tyr Arg Arg Leu Ser Leu Tyr Val Thr Pro Ser Arg Leu 
                245                 250                 255     


Glu Gly Phe Gly Leu Thr Pro Leu Glu Ala Met Ala Ser Gln Val Ala 
            260                 265                 270         


Val Val Thr Ser Asp Val Gly Ile Phe Lys Glu Leu Val Val Glu Gly 
        275                 280                 285             


Thr Gly Thr Val Val Lys Val Gly Asp Gly Ser Ala Leu Thr Ala Ala 
    290                 295                 300                 


Ile Glu Pro Tyr Phe Ala Asp Val Glu Lys Thr Leu Ala Ala Gly Lys 
305                 310                 315                 320 


Lys Ala Leu Thr His Val Arg Thr His Phe Pro Leu Glu Lys Glu Ala 
                325                 330                 335     


Asn Glu Ile Glu Ser Val Tyr Lys Glu Leu Phe Ala Glu Lys Ile Pro 
            340                 345                 350         


<210>  4
<211>  352
<212>  PRT
<213>  Bartonella bacilliformis

<400>  4

Met His Val Ser Leu Lys Glu Thr Asp Ile Ile Val Pro His Phe Lys 
1               5                   10                  15      


Lys Arg Leu Ser Gly Ile Lys Ser Thr Val Ile Gln Leu Ile Pro Leu 
            20                  25                  30          


Gln Arg Lys Gln Gly Ile Arg Ile Ser Ser Phe Gly Val Gly Leu Pro 
        35                  40                  45              


Lys Asn Leu Pro Thr Leu Arg Val Arg Asp Ile Phe Gly Leu Trp Lys 
    50                  55                  60                  


Ser Pro Ala Gly Lys Ser Phe Arg Val Trp His Ala Arg Arg Asn Ile 
65                  70                  75                  80  


Glu Met Leu Val Gly Val Phe Leu Arg Asp Val Leu Arg Met Lys Leu 
                85                  90                  95      


Arg Leu Val Phe Thr Ser Ala Ser Glu Arg His His Lys Phe Ser Thr 
            100                 105                 110         


Arg Trp Leu Ile Arg Arg Met Asp Glu Val Ile Ala Val Ser Ser Arg 
        115                 120                 125             


Val Gly Thr Tyr Leu Asn Val Pro Tyr Thr Val Ile Lys His Gly Val 
    130                 135                 140                 


Asn Leu Glu Asn Phe Ser Pro Pro Lys Thr Ala Tyr Asp Tyr Phe Ser 
145                 150                 155                 160 


Ala Thr Gly Leu Pro Gly Lys Tyr Ala Val Gly Cys Phe Gly Arg Ile 
                165                 170                 175     


Arg Tyr Leu Lys Gly Thr Asp Leu Phe Val Asp Ala Met Leu Ala Leu 
            180                 185                 190         


Leu Pro Arg Tyr Pro Asp Trp Thr Ala Ile Ile Ala Gly Arg Thr Thr 
        195                 200                 205             


Met Gln His Cys Asp Phe Glu Lys Glu Leu Arg Arg Lys Ile Ala Ala 
    210                 215                 220                 


Ala Gly Leu Asn Asp Arg Ile Ile Met Leu Gly Glu Ile Leu Asp Thr 
225                 230                 235                 240 


Pro Leu Trp Tyr Arg Arg Met Ser Leu Tyr Val Ala Pro Ser Arg Thr 
                245                 250                 255     


Glu Gly Phe Gly Leu Thr Pro Leu Glu Ala Met Ala Ser Gln Thr Ala 
            260                 265                 270         


Val Val Thr Ser Asp Ala Gly Ile Tyr Glu Lys Leu Ile Val Glu Gly 
        275                 280                 285             


Thr Gly Thr Val Val Lys Glu Leu Asn Ala Leu Ala Phe Thr Glu Ala 
    290                 295                 300                 


Ile Glu Pro Tyr Phe Ala Asp Leu Asp Lys Thr Phe Ala Thr Glu Gln 
305                 310                 315                 320 


Arg Ala Leu Ala His Val Arg Thr His Phe Pro Leu Glu Lys Glu Ala 
                325                 330                 335     


Ala Glu Ile Gly Ala Val Tyr Glu Lys Ile Phe Ala Ala Lys Met Phe 
            340                 345                 350         


<210>  5
<211>  340
<212>  PRT
<213>  Ochrobactrum anthropi

<400>  5

Met Ala Pro Asn Phe Lys Arg Arg Leu Ser Gly Val Thr Ser Thr Ile 
1               5                   10                  15      


Val Gln Leu Ile Pro Leu Gln Arg Ala Lys Gly Leu Asn Ile Ala Thr 
            20                  25                  30          


Met Gly Pro Gly Leu Pro Asp Thr Leu Pro His Leu Gly Arg Ser Ala 
        35                  40                  45              


Leu Trp Ser Phe Trp Ser Lys Pro Ala Thr Lys Pro Phe Arg Ile Trp 
    50                  55                  60                  


His Ala Arg Arg Asn Ile Glu Met Leu Ala Gly Ile Phe Met Arg Asp 
65                  70                  75                  80  


Val Leu Arg Met Lys Leu Arg Leu Ile Phe Thr Ser Ala Ala Gln Arg 
                85                  90                  95      


Asp His Lys Pro Phe Thr Lys Trp Leu Ile Arg Arg Met Asn Ala Val 
            100                 105                 110         


Ile Ala Thr Ser Gly Arg Ser Gly Ser Phe Leu Glu Val Pro His Gln 
        115                 120                 125             


Val Ile Met His Gly Val Asp Leu Glu Arg Phe His Pro Pro Val Gly 
    130                 135                 140                 


Asp Glu Asp Ser Phe Ala Ala Ser Gly Leu Pro Gly Lys Tyr Ala Val 
145                 150                 155                 160 


Gly Cys Phe Gly Arg Val Arg Ser Ser Lys Gly Thr Asp Leu Phe Val 
                165                 170                 175     


Asp Ala Met Ile Ala Leu Leu Pro Gln Tyr Pro Asp Trp Thr Ala Ile 
            180                 185                 190         


Ile Thr Gly Arg Thr Thr Ala Glu His Gln Ser Phe Glu Asp Ala Leu 
        195                 200                 205             


Lys Ala Lys Ile Ala Ala Ala Gly Leu Gln Asp Arg Ile Leu Ile Leu 
    210                 215                 220                 


Gly Glu Val Pro Asp Ile Arg Val Trp Tyr Arg Arg Leu Thr Leu Tyr 
225                 230                 235                 240 


Val Ala Pro Ser Arg Asn Glu Gly Phe Gly Leu Thr Pro Leu Glu Ala 
                245                 250                 255     


Met Ala Ser Gln Thr Ala Val Val Ala Ser Asp Ala Gly Ala Tyr Ala 
            260                 265                 270         


Glu Met Ile Val Glu Gly Thr Gly Thr Ser Val Ala Ala Gly Asp Gly 
        275                 280                 285             


Asp Ala Leu Arg Lys Ala Ile Glu Pro Tyr Leu Ala Asp Pro Ala Leu 
    290                 295                 300                 


Ala Glu Arg Asp Gly Glu Asn Ala Leu Arg His Val Arg Ala Thr Phe 
305                 310                 315                 320 


Pro Leu Glu Lys Glu Ala Ala Ala Ile Ser Ala Val Tyr Glu Arg Val 
                325                 330                 335     


Phe Ala Gly Lys 
            340 


<210>  6
<211>  350
<212>  PRT
<213>  Ochrobactrum intermedium

<400>  6

Met Lys Val Arg Val Gln Asp Val Glu Val Val Ala Pro Asn Phe Lys 
1               5                   10                  15      


Arg Arg Leu Ser Gly Val Thr Ser Thr Ile Val Gln Leu Ile Pro Leu 
            20                  25                  30          


Gln Arg Ala Lys Gly Leu Asn Ile Ala Thr Met Gly Pro Gly Leu Pro 
        35                  40                  45              


Asp Thr Leu Pro His Leu Gly Trp Gly Ala Leu Leu Ser Phe Trp Ser 
    50                  55                  60                  


Lys Pro Arg Thr Lys Pro Phe Arg Ile Trp His Ala Arg Arg Asn Ile 
65                  70                  75                  80  


Glu Met Leu Ala Gly Ile Phe Met Arg Asp Val Leu Arg Met Lys Leu 
                85                  90                  95      


Arg Leu Ile Phe Thr Ser Ala Ala Gln Arg Asp His Lys Pro Phe Thr 
            100                 105                 110         


Lys Trp Leu Ile Arg Arg Met Asn Ala Val Ile Ala Thr Ser Gly Arg 
        115                 120                 125             


Ser Gly Ser Phe Leu Gln Val Pro His Asp Val Ile Met His Gly Val 
    130                 135                 140                 


Asp Leu Gln Arg Phe His Pro Pro Val Gly Asp Asp Asp Ser Phe Ala 
145                 150                 155                 160 


Ala Ser Gly Leu Pro Gly Lys Tyr Ala Val Gly Cys Phe Gly Arg Val 
                165                 170                 175     


Arg Ser Ser Lys Gly Thr Asp Leu Phe Val Asp Ala Met Val Ala Leu 
            180                 185                 190         


Leu Pro Lys Tyr Pro Asp Trp Thr Ala Ile Ile Thr Gly Arg Thr Thr 
        195                 200                 205             


Ala Glu His Gln Ser Phe Glu Asp Ala Leu Lys Ala Lys Ile Ala Ala 
    210                 215                 220                 


Ala Gly Leu Gln Asp Arg Ile Leu Ile Leu Gly Glu Val Pro Asp Ile 
225                 230                 235                 240 


Arg Val Trp Tyr Arg Arg Leu Thr Leu Tyr Val Ala Pro Ser Arg Asn 
                245                 250                 255     


Glu Gly Phe Gly Leu Thr Pro Leu Glu Ala Met Ala Ser Gln Thr Ala 
            260                 265                 270         


Val Val Ala Ser Asp Ala Gly Ala Tyr Ala Glu Met Ile Val Asp Gly 
        275                 280                 285             


Thr Gly Thr Ser Val Ala Ala Gly Asp Gly Glu Ala Leu Arg Lys Ala 
    290                 295                 300                 


Val Glu Pro Tyr Leu Ala Asp Pro Ala Leu Ala Glu Arg Asp Gly Glu 
305                 310                 315                 320 


Asn Ala Leu Arg His Val Arg Ala Thr Phe Pro Leu Glu Lys Glu Ala 
                325                 330                 335     


Ala Ala Ile Ser Gly Val Tyr Glu Arg Val Phe Ala Gly Lys 
            340                 345                 350 


<210>  7
<211>  351
<212>  PRT
<213>  Agrobacterium tumefaciens

<400>  7

Met Ser His Val Ser Leu Lys Asp Val Gln Val Leu Ala Pro Asn Phe 
1               5                   10                  15      


Lys Arg Arg Leu Ser Gly Val Thr Ser Thr Ile Val Gln Leu Ile Pro 
            20                  25                  30          


Val Gln Asn Arg Leu Gly Gln Lys Val Gly Thr Ile Gly Pro Gly Leu 
        35                  40                  45              


Pro Pro His Leu Pro His Val Arg Phe Arg Asp Leu Trp Arg Leu Trp 
    50                  55                  60                  


Gln Asn Gly Pro Ser Gly Gly Pro Arg Ile Trp His Ala Arg Arg Asn 
65                  70                  75                  80  


Leu Glu Met Leu Pro Gly Ile Phe Met Arg Asp Val Leu Arg Met Lys 
                85                  90                  95      


Val Lys Leu Leu Phe Thr Ser Ala Ala Gln Arg Arg His Ser Ala Tyr 
            100                 105                 110         


Thr Arg Phe Leu Ile Ser Lys Met Asp Ala Val Val Ala Thr Ser Thr 
        115                 120                 125             


Arg Ser Gly Ser Phe Leu Glu Val Pro His Arg Val Val Met His Gly 
    130                 135                 140                 


Val Asp Thr Glu Leu Phe His Pro Ala Thr Gly Pro Glu Asp Thr Ile 
145                 150                 155                 160 


Ala Ala Thr Gly Leu Pro Gly His Tyr Leu Leu Gly Cys Phe Gly Arg 
                165                 170                 175     


Val Arg His Gln Lys Gly Thr Asp Leu Phe Val Arg Ala Met Ile Glu 
            180                 185                 190         


Leu Leu Pro His Tyr Pro Gln Trp Thr Ala Val Val Ser Gly Arg Val 
        195                 200                 205             


Thr Ala Glu His Lys Ala Phe Gly Asp Thr Leu Lys Ala Asp Val Ala 
    210                 215                 220                 


Ala Ala Gly Leu Thr Asp Arg Ile Ile Phe Gln Gly Glu Val Asp Asp 
225                 230                 235                 240 


Ile Lys Pro Trp Tyr Arg Arg Leu Thr Leu Tyr Val Ala Pro Ser Arg 
                245                 250                 255     


Asn Glu Gly Phe Gly Leu Thr Pro Leu Glu Ala Met Ala Ser Glu Thr 
            260                 265                 270         


Ala Val Val Ala Ser Asn Ala Gly Ala Tyr Glu Glu Met Ile Val Thr 
        275                 280                 285             


Gly Glu Thr Gly Trp Val Val Gly Ala Gly Asp Tyr Ala Ser Leu Arg 
    290                 295                 300                 


Asp Ala Ile Lys Thr Tyr Leu Ala Asp Pro Ala Leu Ala Lys Ala His 
305                 310                 315                 320 


Ala Ser Ala Gly Leu Ala His Val Arg Ser Thr Phe Pro Leu Glu Lys 
                325                 330                 335     


Glu Ala Thr Cys Leu Gly Glu Val Tyr Glu Ala Leu Gln Arg Gly 
            340                 345                 350     


<210>  8
<211>  519
<212>  PRT
<213>  Brucella melitensis

<400>  8

Met Asn Lys Leu Gly Val Phe Ile Gly Tyr Asn Pro Gly Gln Leu Asp 
1               5                   10                  15      


Pro Tyr Gln Gly Ile Ser Arg Leu Ile Ala Phe Val Ile Lys Gly Ala 
            20                  25                  30          


Leu Asn Gln Gly Ser Gly Val Thr Ile Ala Cys Pro Gly Trp Leu Lys 
        35                  40                  45              


Asp Asp Val Arg Val Leu Leu Glu Asp Ala Asp Ile Pro Leu Glu Ala 
    50                  55                  60                  


Val Lys Ile Ile Ala Thr Asn Gly Gln Pro Pro Leu Ala Ser Leu Trp 
65                  70                  75                  80  


Lys Leu Arg Asp Lys Phe Arg Lys Arg Arg Thr Ser Lys Arg Lys Arg 
                85                  90                  95      


Leu Trp Leu Glu Arg Tyr Gly Lys Asn Val Ala Asn Phe Val Ala Glu 
            100                 105                 110         


Trp Leu Ser Leu Arg Ser Tyr Trp Gly Ile Phe Leu Gly Ala Ala Ala 
        115                 120                 125             


Ile Ala Val Val Thr Ile Leu Leu Ala Val Pro Ile Ala Ile Ala Phe 
    130                 135                 140                 


Thr Ala Leu Ile Gly Leu Leu Phe Ala Arg Arg Leu Ile Arg Arg Val 
145                 150                 155                 160 


Ile Arg Ser Lys Leu Gly Leu Phe Phe His Lys Asn Ala Asn Gln Phe 
                165                 170                 175     


Asn Lys Leu Met Ser Ser Asp Glu Thr Ile Asp Arg Met Arg Glu Arg 
            180                 185                 190         


Glu Phe Ser Leu Leu Met Lys Lys Ile Asn Ala Gln Lys Asp Ile Lys 
        195                 200                 205             


Val Trp Tyr Val Pro Ala Met Phe Trp Pro Glu Val Ala Asn Ile Lys 
    210                 215                 220                 


Ser Lys Ile Val Met Ala Ala Pro Asp Ile Val Phe Phe Asp Tyr Pro 
225                 230                 235                 240 


Gly Asn Phe Arg Gly Ile Arg Glu His Asn Ser Tyr Asp Arg Met Leu 
                245                 250                 255     


Lys Ser Leu Arg Ser Ala Asp His Leu Val Cys Tyr Ser Glu Asn Ala 
            260                 265                 270         


Lys Gln Lys His Phe Val Glu Arg Cys Asp Val Pro Ala Glu Lys Ile 
        275                 280                 285             


Thr Val Ile Arg His Gly Phe Val Asp Leu Gly Ala Ser Gly Ala Ala 
    290                 295                 300                 


Ile Leu Arg Gln Asp Ala Leu Asp Thr Leu His Ala Phe Ile Lys Lys 
305                 310                 315                 320 


Asn Asp Gly Arg Met Pro Glu Tyr Leu Lys Gly Phe Arg Phe Asp Asp 
                325                 330                 335     


Val Pro Phe Phe Phe Tyr Ser Ser Gln Leu Arg Pro His Lys Asn Ile 
            340                 345                 350         


Glu Gly Leu Ile Arg Ala Tyr Ala Lys Val Leu Lys Glu His Gln Arg 
        355                 360                 365             


Pro Ala Lys Leu Ile Leu Thr Ala Gln Phe Gln Tyr Asp Lys Arg Ile 
    370                 375                 380                 


Gln Thr Phe Ile Asp Asp Asn Gly Leu His Ala Asp Val Leu Ser Leu 
385                 390                 395                 400 


His Ser Leu Pro Asn Lys Val Leu Ala Ala Leu Tyr His Leu Ala Ser 
                405                 410                 415     


Leu Ser Val Thr Pro Thr Asn Phe Glu Gly Gly Phe Pro Phe Thr Phe 
            420                 425                 430         


Ser Glu Ala Tyr Ser Val Gly Thr Pro Ser Ile Met Ser Arg Ile Pro 
        435                 440                 445             


Val Val Gln Glu Val Ile Asp Asp Pro Glu Leu Gln Asp Leu Met Thr 
    450                 455                 460                 


Phe Asn Pro Leu Asp Val Asp Asp Ile Ala Asn Lys Met Ile Phe Gly 
465                 470                 475                 480 


Leu Asp Asn Arg Gln Arg Leu Phe Glu Ala Gln Ser Ser Leu Tyr Ala 
                485                 490                 495     


Lys Leu Ser Ala Arg Thr Trp Gln Val Ala Ala Asn Asp Tyr Leu Ser 
            500                 505                 510         


Leu Leu Lys Ser Val Ala Asp 
        515                 


<210>  9
<211>  410
<212>  PRT
<213>  Brucella melitensis

<400>  9

Met Ala Pro Arg His Ile Thr Val Ile Leu Pro Ala Lys Tyr Arg Gly 
1               5                   10                  15      


Gly Ser Leu Arg Val Thr Lys Asn Ile Val Arg Met Leu Leu Lys Gly 
            20                  25                  30          


Ser Gln Asn Tyr Gly Glu Gln Cys Gln Val Arg Leu Ala Val Arg Ala 
        35                  40                  45              


Asp Thr Tyr Asp Ile Gly Glu Glu Phe Arg Asp Leu Ile Asp Asn Gly 
    50                  55                  60                  


Val Glu Val Arg Glu Ile Ser Phe Lys Glu Val Pro Pro Glu Asp Val 
65                  70                  75                  80  


Asn Asn Ala Asn Tyr Phe Gln Gly Arg Asn Ile Asp Leu Gln Ser Arg 
                85                  90                  95      


Thr Tyr Trp Leu Met Glu Asp Gly Gln Asn Asn Cys Ala Asp Ser Asp 
            100                 105                 110         


Leu Trp Leu Val Val Ser Tyr Ser Val Glu Tyr Pro Ile Ala Pro Ile 
        115                 120                 125             


Arg Pro Thr Leu Ile Phe Ala Thr Asp Phe Ile Gln Arg Tyr Val Pro 
    130                 135                 140                 


Asp Ile Ile Trp Pro Pro Arg Pro Gly Glu Gly Asp Ala Glu Ala Leu 
145                 150                 155                 160 


Ala Phe Leu Arg Gln Ser Asp Gly Val Leu Ala Thr Thr Pro His Thr 
                165                 170                 175     


Arg Leu Asp Ala Ile Ser Tyr Ala Gly Leu Pro Ala Ser Lys Val Tyr 
            180                 185                 190         


Leu Ala Pro Met Glu Phe Asp Pro Thr Phe Leu Asp Arg Tyr Arg Ser 
        195                 200                 205             


Val Ser Lys Val Lys Glu Pro Tyr Phe Leu Trp Pro Thr Asn Pro Asn 
    210                 215                 220                 


Ala His Lys Asn His Ala Lys Ala Phe Gln Ala Leu Asp Leu Tyr Tyr 
225                 230                 235                 240 


Gly Lys Leu Lys Gly Lys Ile Lys Thr Lys Ile Val Gly Val Ser Ser 
                245                 250                 255     


Val Arg Met Asp Pro Ser His Arg Trp Gln Ala Lys Tyr Glu Asn Lys 
            260                 265                 270         


Ala Tyr Val Lys Ser Val Arg Glu Ile Val Ala Gly Leu Asp Asn Leu 
        275                 280                 285             


Lys Ser Asn Val Glu Phe Ala Gly Glu Val Ala Asp Lys Glu Tyr Ala 
    290                 295                 300                 


Glu Leu Leu Ala Ser Ala Cys Phe Leu Trp His Pro Thr Leu Ala Asp 
305                 310                 315                 320 


Asn Gly Thr Phe Ala Ala Val Glu Ala Ala Tyr Met Gly Cys Pro Thr 
                325                 330                 335     


Leu Ser Asn Asp Tyr Pro Gln Met Arg Tyr Ile Ser Asn Arg Phe Glu 
            340                 345                 350         


Ile Pro Met Gln Tyr Phe Asn Ala Arg Ser Val Lys Glu Met Ala Ser 
        355                 360                 365             


Ala Leu Lys Gln Met Glu Glu Thr Pro Ile Asp Val Gly Leu Leu Pro 
    370                 375                 380                 


Ser Arg Glu Thr Leu Ser Leu His Ser Trp Glu Ala His Ala Ser Glu 
385                 390                 395                 400 


Tyr Trp Asp Val Ile Val Arg Ala Ala Ala 
                405                 410 


<210>  10
<211>  377
<212>  PRT
<213>  Brucella melitensis

<400>  10

Met Pro His Leu Tyr Trp Arg Asn Met Arg Val Leu His Phe Phe Lys 
1               5                   10                  15      


Thr Tyr Trp Pro Asp Thr Phe Gly Gly Ile Glu Arg Thr Ile His Ala 
            20                  25                  30          


Ile Ala Lys Gly Val Ala Glu His Gly Ile Ala Ser Asp Val Leu Ser 
        35                  40                  45              


Leu Ser Ala Lys Pro Glu Glu Asn Thr Arg Asn Phe Asp Gly His Met 
    50                  55                  60                  


Ala Tyr Lys Ala Lys Leu Asp Leu Glu Phe Ala Ser Thr Gly Leu Ser 
65                  70                  75                  80  


Arg Asp Val Phe Ser Arg Phe Arg Glu Leu Ser Ser Gln Ala Asp Val 
                85                  90                  95      


Ile His Tyr His Phe Pro Trp Pro Met Ser Asp Ile Val Gln Ile Gly 
            100                 105                 110         


Val Arg Pro Asp Lys Pro Thr Ile Val Thr Tyr His Ser Asp Ile Val 
        115                 120                 125             


Lys Gln Lys Leu Leu Leu Gln Phe Tyr Arg Pro Leu Met Asn Arg Phe 
    130                 135                 140                 


Leu Gly Ser Val Asp Arg Ile Val Ala Thr Ser Pro Asn Tyr Leu Ala 
145                 150                 155                 160 


Thr Ser Asp Val Leu Gln Arg Phe Ser Asp Lys Thr Thr Val Ile Pro 
                165                 170                 175     


Leu Gly Leu Asp Glu Ser Asp Tyr Ser Ala Ala Asp Ala Thr Thr Lys 
            180                 185                 190         


Ala Arg Trp Arg Glu Arg Phe Pro Arg Pro Phe Phe Leu Phe Val Gly 
        195                 200                 205             


Val Leu Arg Tyr Tyr Lys Gly Leu Arg Thr Leu Leu Ala Ala Ala Arg 
    210                 215                 220                 


Thr Ser Asp Ile Asp Ile Val Ile Val Gly Asp Gly Pro Met Lys Pro 
225                 230                 235                 240 


Gln Leu Ile Ala Tyr Ala Asn Glu His Asn Leu Ser His Val His Phe 
                245                 250                 255     


Ala Gly Ala Leu Pro Asp Thr Asp Lys Thr Ala Leu Leu Glu Leu Ser 
            260                 265                 270         


Ala Gly Leu Ile Phe Pro Ser His Leu Arg Ser Glu Ala Phe Gly Leu 
        275                 280                 285             


Ser Leu Val Glu Ala Ser Met Phe Gly Lys Pro Met Ile Ser Cys Glu 
    290                 295                 300                 


Ile Gly Thr Gly Thr Ser Tyr Val Asn Leu Asn Gly Gln Thr Gly Ile 
305                 310                 315                 320 


Val Val Pro Pro Gln Asn Pro Glu Ala Leu Ser Ala Ala Met Arg Ser 
                325                 330                 335     


Ile Ala His Asp Thr Glu Gln Ala Lys Val Phe Gly Met Asn Ala Arg 
            340                 345                 350         


Ala Arg Tyr Ile Glu His Phe Thr Ala Asp Lys Met Ala Leu Glu Tyr 
        355                 360                 365             


Ala Lys Asn Tyr Thr Ser Leu Met Gln 
    370                 375         


<210>  11
<211>  372
<212>  PRT
<213>  Brucella melitensis

<400>  11

Met Arg Ile Gly Val Asp Ala Arg Asn Leu Val Asn Asn Ile Thr Gly 
1               5                   10                  15      


Ile Ser Arg Tyr Val Met Glu Asn Cys Arg Glu Leu Tyr Glu Arg Gly 
            20                  25                  30          


His Glu Leu Val Leu Tyr Thr Pro Glu Lys Pro Arg Val Gln Leu Ser 
        35                  40                  45              


Ser Ser Glu Gly Phe Asp Phe Arg Val Ser Asn Phe Gln Gly Pro Ala 
    50                  55                  60                  


Gly Arg Leu Phe Trp Ser Gln Thr Val Leu Pro Leu Gln Leu Arg Lys 
65                  70                  75                  80  


Asp Arg Ile Asp Val Phe Trp Gly Pro Ala His Arg Leu Pro Ala Leu 
                85                  90                  95      


Lys Gly Ala Ile Pro Ser Val Val Ser Ile His Asp Leu Val Trp Tyr 
            100                 105                 110         


Tyr Ala Ser Ser Thr Met Arg Leu Gln Gly Trp Leu Ala Asp Arg Phe 
        115                 120                 125             


Leu Met Lys Gly Ala Leu Arg Asn Ala Asp Gln Ile Val Ala Val Ser 
    130                 135                 140                 


Tyr Ala Thr Ser Ser Ala Ile Ser Ser Val Phe Pro Gln Tyr Thr Ser 
145                 150                 155                 160 


Lys Ile Gln Met Val Tyr Pro Gly Val Ser His Phe Asn Arg Ile Gly 
                165                 170                 175     


Thr Ser Asn Ile Leu Lys Glu His Arg Ile Asn Lys Ser Tyr Gly Leu 
            180                 185                 190         


Phe Ile Gly Thr Leu Glu Pro Arg Lys Asn Leu Ile Arg Leu Leu Glu 
        195                 200                 205             


Ala Tyr Ala Asn Leu Pro Glu Cys Val Arg Asn Asn Phe Leu Leu Val 
    210                 215                 220                 


Val Ala Gly Gly Lys Gly Trp Asn Leu Gly Asp Ile Gly Lys Thr Ile 
225                 230                 235                 240 


Asn Arg Leu Gly Ile Ala Glu Tyr Thr Arg Leu Thr Gly Tyr Val Thr 
                245                 250                 255     


Asp Ser Asp Leu Asn Asp Leu Tyr Arg Asn Ala Arg Thr Leu Leu Met 
            260                 265                 270         


Pro Ser Leu Tyr Glu Gly Phe Gly Leu Pro Ile Ile Glu Ala Gln Ala 
        275                 280                 285             


Tyr Gly Val Pro Val Ile Thr Ser Asn Cys Ser Ser Met Pro Glu Val 
    290                 295                 300                 


Ala Gly Asp Ala Ala Ile Leu Val Asp Pro Leu Asn Val Ala Glu Ile 
305                 310                 315                 320 


Ser Asn Ala Leu Tyr Arg Ile Ala Thr Asp Asn Lys Leu Trp Gln Arg 
                325                 330                 335     


Lys Ser Leu Leu Ala Leu Gln Asn Ile Glu Arg Phe Asn Trp His Asn 
            340                 345                 350         


Ser Ile Glu Lys Leu Glu Ser Val Phe Ile Lys Ala Arg Glu Ser Lys 
        355                 360                 365             


Leu Met Thr Tyr 
    370         


<210>  12
<211>  362
<212>  PRT
<213>  Brucella melitensis

<400>  12

Met Lys Lys Val Ala Leu Ile Thr Gly Ile Thr Gly Gln Asp Gly Ala 
1               5                   10                  15      


Tyr Leu Ala Glu Leu Leu Leu Gln Lys Gly Tyr Ala Val His Gly Ile 
            20                  25                  30          


Lys Arg Arg Thr Ser Gln Phe Asn Thr Ala Arg Ile Asp His Leu Tyr 
        35                  40                  45              


His Asp Pro His Glu Gln Gly Val Asp Leu Thr Leu His His Gly Asp 
    50                  55                  60                  


Leu Thr Asp Thr Ser Ser Leu Val Arg Ile Met Gln Leu Val Arg Pro 
65                  70                  75                  80  


Asp Glu Val Tyr Asn Leu Gly Ala Gln Ser His Val Ala Val Ser Phe 
                85                  90                  95      


Glu Glu Pro Glu Tyr Thr Ala Asn Ser Asp Ala Leu Gly Ala Leu Arg 
            100                 105                 110         


Leu Leu Glu Ala Ile Arg Ile Leu Gly Met Glu Lys Gln Thr Arg Tyr 
        115                 120                 125             


Tyr Gln Ala Ser Thr Ser Glu Leu Tyr Gly Leu Val Gln Glu Ile Pro 
    130                 135                 140                 


Gln Lys Glu Thr Thr Pro Phe Tyr Pro Arg Ser Pro Tyr Ala Ala Ala 
145                 150                 155                 160 


Lys Leu Tyr Ala Tyr Trp Ile Thr Val Asn Tyr Arg Glu Ala Tyr Gly 
                165                 170                 175     


Ile Tyr Ala Cys Asn Gly Ile Leu Phe Asn His Glu Ser Pro Leu Arg 
            180                 185                 190         


Gly Glu Thr Phe Val Thr Arg Lys Ile Thr Arg Ala Leu Ala Arg Ile 
        195                 200                 205             


Lys Ile Gly Asn Gln Asn Arg Leu Tyr Leu Gly Asn Leu Asp Ser Leu 
    210                 215                 220                 


Arg Asp Trp Gly His Ala Arg Asp Tyr Val Glu Met Gln Trp Leu Met 
225                 230                 235                 240 


Leu Gln Gln Asp Gln Pro Glu Asp Phe Val Ile Ala Thr Gly Lys Gln 
                245                 250                 255     


Tyr Ser Val Arg Glu Phe Val Thr Leu Ala Ala Lys Asp Ile Gly Ile 
            260                 265                 270         


Glu Met Arg Trp Glu Gly Ser Gly Glu Ala Glu Lys Gly Tyr Asp Ala 
        275                 280                 285             


Lys Thr Gly Ala Cys Ile Val Glu Val Asp Pro Arg Tyr Phe Arg Pro 
    290                 295                 300                 


Ala Glu Val Glu Thr Leu Leu Gly Asp Ala Thr Lys Ala His Gln Lys 
305                 310                 315                 320 


Leu Gly Trp Lys Pro Lys Ile Ser Phe Glu Thr Leu Val Ser Glu Met 
                325                 330                 335     


Ile Ala Glu Asp Leu Ala Ala Ala Ala Arg Glu Asn Leu Leu Arg Glu 
            340                 345                 350         


His Gly His Gln Phe Phe Ala Pro Lys Glu 
        355                 360         


<210>  13
<211>  380
<212>  PRT
<213>  Brucella melitensis

<400>  13

Met Val Thr Asn Phe Ser Pro Leu Arg Asn Asp Pro Tyr Met Asp Ile 
1               5                   10                  15      


Pro Val Tyr Ser Pro Tyr Leu Cys Gly Asn Phe Lys Lys Tyr Val Asn 
            20                  25                  30          


Glu Cys Leu Asp Thr Gly Trp Ile Ser Ser Arg Gly Glu Phe Ile Ser 
        35                  40                  45              


Arg Phe Glu Asp Ala Phe Ala Gln Tyr Val Asp Val Pro Ser Ala Ala 
    50                  55                  60                  


Ser Val Ala Asn Gly Thr Val Ala Leu His Leu Ala Leu Asp Ala Leu 
65                  70                  75                  80  


Gly Ile Gly Ala Gly Asp Glu Val Ile Val Pro Thr Phe Thr Tyr Ile 
                85                  90                  95      


Ala Ser Val Asn Thr Ile Leu Gln Thr Gly Ala Thr Pro Val Tyr Val 
            100                 105                 110         


Asp Ser Leu Glu Asn Thr Leu Gln Ile Asp Pro Glu Gly Val Arg Leu 
        115                 120                 125             


Ala Ile Thr Glu Arg Thr Lys Ala Val Met Val Val His Leu Tyr Gly 
    130                 135                 140                 


His Pro Cys Asp Met Asp Ser Ile Arg Glu Ile Cys Asp Glu Lys Ser 
145                 150                 155                 160 


Leu Leu Leu Val Glu Asp Cys Ala Glu Gly Phe Gly Thr Lys Trp Lys 
                165                 170                 175     


Asn Ser His Val Gly Thr Phe Gly Asp Val Ala Thr Phe Ser Phe Phe 
            180                 185                 190         


Gly Asn Lys Thr Ile Thr Thr Gly Glu Gly Gly Met Val Leu Ala Arg 
        195                 200                 205             


Asn Pro Gln Val Met Glu Lys Cys Arg His Leu Lys Ser Gln Gly Thr 
    210                 215                 220                 


Ser Pro Thr Arg Glu Tyr Trp His Asp Ala Leu Ala Tyr Asn Tyr Arg 
225                 230                 235                 240 


Met Thr Asn Ile Gln Ala Ala Ile Gly Leu Ser Gln Ile Glu Met Ala 
                245                 250                 255     


Asp Glu Ile Leu Ser Leu Lys Ala Arg Thr Ala Ala Ser Tyr Ala Ser 
            260                 265                 270         


Lys Leu Ala Gly Leu Pro Leu Arg Met His Thr Pro Val Gly Asp Val 
        275                 280                 285             


Lys His Ser Tyr Trp Met Cys Ser Ile Val Leu Asp Asn Ser Glu His 
    290                 295                 300                 


Arg Glu Pro Leu Arg Gln His Leu Arg Glu Asn Gly Val Asp Thr Arg 
305                 310                 315                 320 


Pro Phe Phe Pro Pro Ala His Arg Met Pro His Ser Ala Ser Thr Gly 
                325                 330                 335     


Ser Tyr Pro Val Ala Asp Ser Leu Ser Ala Arg Gly Leu Asn Leu Pro 
            340                 345                 350         


Ser Phe Pro His Ile Thr Asp Val Glu Ile Ser Phe Val Cys Asp Leu 
        355                 360                 365             


Val Arg Ser Tyr Phe Ser Asn His Ser Asn His Ile 
    370                 375                 380 


<210>  14
<211>  265
<212>  PRT
<213>  Brucella melitensis

<400>  14

Met Arg Arg Phe Arg Met Ile Ser Tyr Met Ala Asn Val Trp Lys Val 
1               5                   10                  15      


Arg His Phe Trp Trp His Leu Ser Met Ser Asp Leu Arg Gly Arg Phe 
            20                  25                  30          


Arg Arg Ser Ser Leu Gly Ile Leu Trp Ala Val Ile Gln Pro Leu Ala 
        35                  40                  45              


Leu Thr Leu Leu Leu Ser Phe Val Phe Ser Lys Leu Leu Asn Gln Ser 
    50                  55                  60                  


Ile Ser Ala Tyr Ala Pro Tyr Ile Leu Ser Gly Ile Ile Ile Trp Glu 
65                  70                  75                  80  


Tyr Ile Ser Phe Thr Val Val Gly Gly Ser Thr Ala Leu Val Gln Ala 
                85                  90                  95      


Asp Ala Tyr Ile Lys Gln Thr Arg Asn Pro Leu Ala Ile Tyr Thr Leu 
            100                 105                 110         


Arg Asn Thr Val Ser Gly Leu Val Val Leu Ser Val Ala Ser Ile Ser 
        115                 120                 125             


Leu Phe Gly Trp Val Leu Ile Met Phe Pro Glu Asn Phe Ser Leu Ser 
    130                 135                 140                 


Trp Leu Ala Ile Pro Thr Leu Leu Pro Ile Leu Ala Leu Ile Val Trp 
145                 150                 155                 160 


Pro Leu Ala Thr Ile Val Gly Tyr Ile Gly Ala Arg Phe Arg Asp Leu 
                165                 170                 175     


Pro Asn Ala Leu Ala Leu Val Leu Gln Ala Ala Trp Phe Val Ser Pro 
            180                 185                 190         


Val Tyr Phe Lys Glu Ser Met Phe Arg Gln Gly Gly Leu Asn Ala Phe 
        195                 200                 205             


Val Asp Tyr Asn Pro Ile Tyr His Val Met Gln Ile Leu Arg Ala Pro 
    210                 215                 220                 


Val Leu Tyr Gly Glu Trp Pro Thr Ala Thr Asn Tyr Ile Trp Cys Leu 
225                 230                 235                 240 


Gly Val Ser Leu Leu Leu Thr Cys Val Ala Val Ala Val Gly Met Arg 
                245                 250                 255     


Ala Glu Lys Arg Ala Ile Phe Tyr Leu 
            260                 265 


<210>  15
<211>  335
<212>  PRT
<213>  Brucella melitensis

<400>  15

Met Arg Phe Leu Leu Val Ser Phe Phe Val Ser Ala Leu Leu Cys Gly 
1               5                   10                  15      


Ile Gly Leu Phe Leu Leu Ser His Leu Leu Pro Ala Asn Phe Leu Ala 
            20                  25                  30          


Ala Arg Met Ser Ser Arg Ser Asn His Ser Ile Ala Ala Arg Gln Ile 
        35                  40                  45              


Gly Gly Leu Ala Leu Ile Pro Ala Ile Leu Val Thr Leu Ala Ile Phe 
    50                  55                  60                  


Ala Pro Asp Leu Glu Val Asn Met Gln Leu Phe Leu Cys Leu Ser Gly 
65                  70                  75                  80  


Ala Ser Leu Leu Leu Trp Val Val Gly Gly Leu Asp Asp Arg Tyr Glu 
                85                  90                  95      


Leu Ser Glu Ile Ile Arg Leu Gly Ser Gln Leu Leu Ala Ala Ile Thr 
            100                 105                 110         


Val Leu Tyr Gly Leu Gly Pro Asp Phe Arg Leu Leu Pro Asn Leu Leu 
        115                 120                 125             


Pro Tyr Trp Leu Glu Ala Thr Leu Ile Val Phe Ala Leu Ile Ile Ala 
    130                 135                 140                 


Ile Asn Val Thr Asn Phe Met Asp Gly Leu Asp Leu Met Thr Val Ala 
145                 150                 155                 160 


Gly Leu Gly Val Pro Leu Val Gly Ile Ala Leu Leu Gly Ala Leu Gly 
                165                 170                 175     


Leu Thr Gly Leu Thr Ser Ser Gly Ile Gly Ala Val Ala Ala Gly Gly 
            180                 185                 190         


Leu Leu Gly Phe Ala Leu Phe Asn Arg Pro Pro Ala Ser Ile Phe Leu 
        195                 200                 205             


Gly Asp Ser Gly Ser Pro Pro Leu Gly Leu Ile Val Gly Thr Ala Leu 
    210                 215                 220                 


Leu Leu Leu Ala Arg Glu Thr His Ile Val Val Ala Leu Val Leu Pro 
225                 230                 235                 240 


Leu Tyr Tyr Ile Leu Asp Ala Gly Thr Thr Ile Val Met Arg Ala Ala 
                245                 250                 255     


Gln Gly Glu Asn Ile Leu Lys Ala His Ser Lys His Ala Tyr Gln Ile 
            260                 265                 270         


Ala Lys Arg Ser Gly Trp Ser Val Pro Lys Val Val Ala His Val Ala 
        275                 280                 285             


Leu Leu Asn Thr Ile Leu Ile Ala Cys Val Val Ala Leu Leu Ala Leu 
    290                 295                 300                 


Asp His Pro Leu Ala Gln Leu Thr Phe Leu Leu Val Ala Ala Val Ala 
305                 310                 315                 320 


Thr Leu Ile Leu Leu Leu Asp Phe Arg Gly Arg Phe Arg Lys Leu 
                325                 330                 335 


<210>  16
<211>  622
<212>  PRT
<213>  Brucella melitensis

<400>  16

Met Ser Leu Lys Tyr Pro Trp Gln Arg Leu Ala Leu Leu Pro Arg Ile 
1               5                   10                  15      


Ser Lys Gln Ile Ile Leu Val Leu Ser Asp Cys Leu Leu Leu Leu Ala 
            20                  25                  30          


Ser Ala Tyr Leu Ala Phe Val Val Arg Phe Gly Phe Val Phe Val Pro 
        35                  40                  45              


Asn Leu Ala Gln Leu Phe Leu Ile Leu Ile Ala Pro Leu Leu Ala Ile 
    50                  55                  60                  


Pro Val Phe Ile Arg Phe Gly Leu Tyr Arg Ala Ile Ile Arg Tyr Leu 
65                  70                  75                  80  


Ala Glu Arg Ala Ile Trp Ser Thr Phe Gln Ala Thr Ala Val Ala Ala 
                85                  90                  95      


Leu Phe Trp Val Ala Leu Val Phe Leu Met Glu Leu Tyr Gly Ser Thr 
            100                 105                 110         


Gly Leu Pro Arg Ser Val Pro Leu Leu Tyr Trp Leu Leu Ser Thr Val 
        115                 120                 125             


Phe Ile Ser Ala Ser Arg Phe Gly Ala Lys Trp Leu Leu Arg Thr Ala 
    130                 135                 140                 


Glu His Asp Lys Arg Tyr Thr Ser Ser Ala Leu Ile Ile Gly Ile Gly 
145                 150                 155                 160 


Glu Pro Ala Arg Gln Leu Ala Thr Ala Leu Arg Ser His Ser Asp Thr 
                165                 170                 175     


Leu Val Val Gly Phe Ile Asp Pro Ala Gly Gln Leu Ala Gly Met Asp 
            180                 185                 190         


Ile Ile Gly Leu Arg Val Tyr Arg Thr Glu Glu Ile Pro Ser Leu Ile 
        195                 200                 205             


Glu Asn Tyr Gly Ile Lys Gln Val Val Val Ser Glu Pro Ala Leu Glu 
    210                 215                 220                 


Gln Lys Glu Arg Gln Glu Phe Ala Arg Leu Leu Gly Arg Leu Pro Val 
225                 230                 235                 240 


Asn Thr Arg Ile Leu Pro Pro Ile Ala Asp Leu Thr Ala Gly Lys Tyr 
                245                 250                 255     


Leu Val Ser Ala Leu Arg Asn Val Glu Ile Asp Asp Leu Leu Gly Arg 
            260                 265                 270         


Ser Pro Val Pro Pro Asp Thr Thr Leu Leu Arg Glu Val Val Glu Gly 
        275                 280                 285             


Arg Arg Ile Met Ile Thr Gly Ala Gly Gly Ser Ile Gly Ser Gln Leu 
    290                 295                 300                 


Cys Leu Thr Ile Ala Gln Trp Asn Pro Ala Ala Ile Val Leu Phe Glu 
305                 310                 315                 320 


Ser Ser Glu Phe Ala Leu Tyr Gln Ile Asp Arg Gln Leu Arg Gln Phe 
                325                 330                 335     


Ala Ser Cys Thr Val Val Pro Val Leu Gly Ser Val Arg Asp Arg Ala 
            340                 345                 350         


Cys Val Glu Lys Pro Ile Arg Asp His Ser Ile Asp Thr Val Tyr His 
        355                 360                 365             


Cys Ala Ala Tyr Lys His Val Pro Leu Val Glu Arg Asn Pro Leu Val 
    370                 375                 380                 


Gly Ile Phe Asn Asn Val Phe Gly Thr Leu Glu Val Ala Glu Ala Ala 
385                 390                 395                 400 


Leu Asn Thr Asp Val Glu Arg Met Val Leu Ile Ser Ser Asp Lys Ala 
                405                 410                 415     


Val Arg Pro Thr Asn Val Met Gly Ala Thr Lys Arg Trp Ala Glu Leu 
            420                 425                 430         


Val Val Tyr Tyr Tyr Gly Arg Leu Ala Glu Gln Ala Gly Lys Lys Lys 
        435                 440                 445             


Ala Phe Tyr Ser Val Arg Phe Gly Asn Val Leu Gly Ser Asn Gly Ser 
    450                 455                 460                 


Val Val Pro Leu Phe Arg Glu Gln Ile Ala Asn Gly Gly Pro Val Thr 
465                 470                 475                 480 


Leu Thr His Glu Asp Met Thr Arg Tyr Phe Met Ser Ile Lys Glu Ala 
                485                 490                 495     


Ala Glu Leu Ile Val Gln Ser Gly Ala Ile Ala Gln Ser Gly Asp Thr 
            500                 505                 510         


Val Leu Leu Glu Met Gly Glu Pro Val Lys Ile Arg Asp Leu Ala Glu 
        515                 520                 525             


Asn Met Ile Leu Leu Ala Gly Leu Thr Val Arg Asn Glu Glu Asn Pro 
    530                 535                 540                 


Gln Gly Asp Ile Ala Ile Glu Val Thr Gly Ile Arg Glu Gly Glu Lys 
545                 550                 555                 560 


Met Tyr Glu Glu Leu Phe Tyr Asp Pro Ser Leu Ala Gln Arg Thr Arg 
                565                 570                 575     


His Pro Lys Ile Met Arg Ala Pro Gln Gly Ser Lys Ala Val Val Asp 
            580                 585                 590         


Ile Gln Glu Ser Leu Ala Val Leu Arg Thr Ala Met Glu Lys Lys Asp 
        595                 600                 605             


Ile Glu Met Val Arg Lys Val Leu Phe Glu Val Ile Ala Ser 
    610                 615                 620         


<210>  17
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  17
ctggcgtcag caatcagag                                                  19


<210>  18
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  18
gtgcaacgac ctcaacttcc                                                 20


<210>  19
<211>  40
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  19
ggaagttgag gtcgttgcac acgccatcga accttatctg                           40


<210>  20
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  PCR primer

<400>  20
cggctatcgt gcgattct                                                   18


<210>  21
<211>  239
<212>  PRT
<213>  Brucella abortus

<400>  21

Met Asn Val Lys Ala Phe Ile Ile His Leu Lys Arg Ala Thr Asp Arg 
1               5                   10                  15      


Ala Pro Gln Val Glu Lys Leu Ile Lys Glu Leu Pro Val Lys Ala Glu 
            20                  25                  30          


Val Ile Glu Ala Val Asp Ser Arg Ala Leu Asn Lys Asp Glu Ile Ala 
        35                  40                  45              


Arg Ile Tyr Lys Arg Arg Leu His Thr Pro Arg Tyr Pro Phe Ala Leu 
    50                  55                  60                  


Ser Arg Asn Glu Ile Ala Cys Phe Leu Ser His Arg Lys Ala Trp Gln 
65                  70                  75                  80  


Ala Ile Ile Asp Arg Lys Leu Asp Ala Gly Phe Ile Val Glu Asp Asp 
                85                  90                  95      


Ile Ala Leu Thr Glu Asn Phe Met Gly Ala Tyr Arg Ala Ala Val Asp 
            100                 105                 110         


His Leu Glu Pro Gly Gly Phe Ile Arg Phe Thr Phe Arg Asp Asp Arg 
        115                 120                 125             


Glu His Gly Arg Glu Val Phe Arg Asp Glu Ala Val Arg Ile Ile Ile 
    130                 135                 140                 


Pro Asn Pro Ile Gly Leu Gly Met Val Ala Gln Phe Val Ser Tyr Asp 
145                 150                 155                 160 


Ala Ala Gln Lys Leu Leu Asp Ile Thr Gln Thr Phe Asp Arg Pro Val 
                165                 170                 175     


Asp Thr Thr Val Gln Met Arg Trp Val Thr Gly Leu Gln Pro Leu Ser 
            180                 185                 190         


Val Ile Pro Gly Gly Val Lys Glu Ile Ser Ser Gln Leu Gly Gly Thr 
        195                 200                 205             


Thr Ile Gln His Lys Lys Asn Phe Ser Asp Lys Leu Ala Arg Glu Ile 
    210                 215                 220                 


Leu Arg Pro Ile Tyr Arg Met Arg Val Arg Ala Tyr Ser Ser Lys 
225                 230                 235                 


<210>  22
<211>  352
<212>  PRT
<213>  Bartonella henselae

<400>  22

Met His Val Ser Leu Glu Glu Thr Glu Ile Ile Ala Pro His Phe Lys 
1               5                   10                  15      


Lys Arg Leu Ser Gly Ile Thr Ser Thr Val Val Gln Leu Ile Pro Leu 
            20                  25                  30          


Gln Arg Lys Gln Gly Ile Arg Ile Ala Thr Phe Gly Phe Gly Leu Pro 
        35                  40                  45              


Asn Asn Leu Pro Ala Leu Ala Phe Lys Asp Leu Phe Gly Leu Trp Lys 
    50                  55                  60                  


Ser Pro Ile Gly Lys Pro Phe Arg Ile Trp His Ala Arg Arg Asn Ile 
65                  70                  75                  80  


Glu Met Leu Cys Gly Ile Phe Leu Arg Asp Val Leu Arg Met Lys Leu 
                85                  90                  95      


Lys Leu Leu Phe Thr Ser Ala Ser Gln Arg His His Lys Ser Phe Thr 
            100                 105                 110         


Lys Trp Leu Ile Arg Arg Met Asp Lys Val Ile Ala Thr Ser Ile Arg 
        115                 120                 125             


Thr Gly Thr Tyr Leu Glu Val Pro His Gln Val Ile Met His Gly Val 
    130                 135                 140                 


Asp Val Arg Arg Phe Ser Pro Pro Lys Thr Phe Glu Asp Cys Phe Ser 
145                 150                 155                 160 


Ser Ser Gly Phe Pro Gly Lys Tyr Ala Val Gly Cys Phe Gly Arg Val 
                165                 170                 175     


Arg Tyr Ser Lys Gly Thr Asp Leu Phe Val Asp Ala Met Ile Ala Leu 
            180                 185                 190         


Leu Pro Arg Tyr Pro Glu Trp Thr Ala Leu Ile Ala Gly Arg Thr Ile 
        195                 200                 205             


Glu Gln His Tyr Tyr Phe Glu Lys Lys Leu Arg Gln Lys Ile Ala Glu 
    210                 215                 220                 


Ala Gly Leu Asn Asp Arg Ile Val Phe Leu Gly Glu Val Leu Asn Thr 
225                 230                 235                 240 


Pro Leu Trp Tyr Arg Arg Leu Ser Leu Tyr Val Ala Pro Ser Arg Thr 
                245                 250                 255     


Glu Gly Phe Gly Leu Thr Pro Leu Glu Ala Met Ala Ser Gln Thr Ala 
            260                 265                 270         


Val Val Ala Ser Asp Ala Gly Ala Tyr Lys Glu Leu Val Val Glu Gly 
        275                 280                 285             


Thr Gly Thr Ile Val Gln Ala Gly Asp Gly Gly Ala Leu Thr Ala Ala 
    290                 295                 300                 


Ile Glu Pro Tyr Phe Ala Asp Leu Glu Lys Thr Met Ala Ala Gly Glu 
305                 310                 315                 320 


Lys Ala Leu Ala His Val Arg Thr His Phe Pro Leu Glu Lys Glu Ala 
                325                 330                 335     


Ala Ala Ile Arg Asn Val Tyr Glu Thr Val Phe Ala Gln Lys Thr Leu 
            340                 345                 350         


<210>  23
<211>  255
<212>  PRT
<213>  Ochrobactrum anthropi

<400>  23

Met Asn Glu Thr Arg Pro Asp Ile Thr Ala Asn Asp Gly Pro Gln Arg 
1               5                   10                  15      


Ala Val Lys Ala Phe Ile Ile His Leu Glu Arg Ala Thr Asp Arg Gln 
            20                  25                  30          


Pro Gln Val Glu Glu Leu Val Arg Arg Leu Pro Val Glu Thr Asp Val 
        35                  40                  45              


Val Asn Ala Val Asp Gly Arg Thr Leu Asp Ala Gln Thr Ile Ser Arg 
    50                  55                  60                  


Val Tyr Arg Arg Ser Ala His Lys Pro Arg Tyr Pro Phe Gln Leu Ser 
65                  70                  75                  80  


Thr Asn Glu Ile Ala Cys Phe Leu Ser His Arg Lys Ala Trp Gln Ala 
                85                  90                  95      


Ile Val Asp Gln Glu Leu Asp Ala Gly Leu Val Leu Glu Asp Asp Val 
            100                 105                 110         


Glu Leu Thr Pro Glu Phe Ala Ala Ala Tyr Ser Ala Ala Cys Gln Ile 
        115                 120                 125             


Leu Lys Ala Asp Ser Phe Ile Arg Phe Pro Phe Arg Glu Arg Glu Ser 
    130                 135                 140                 


Gly Arg Val Val Leu Asn Thr Glu Thr Leu Arg Ile Ile Glu Pro Val 
145                 150                 155                 160 


Pro Val Gly Leu Gly Met Val Ala Gln Leu Val Gly Arg Glu Ala Ala 
                165                 170                 175     


Gln Arg Leu Leu Ser Ala Thr Glu Val Phe Asp Arg Pro Val Asp Thr 
            180                 185                 190         


Thr Ala Gln Met Asn Trp Val Thr Gly Leu Lys Pro Leu Ser Val Leu 
        195                 200                 205             


Pro Gly Gly Val Lys Glu Ile Ser Val Gln Leu Gly Gly Ser Thr Ile 
    210                 215                 220                 


Gln Lys Ser Arg Ser Leu Pro Asp Lys Leu Lys Arg Glu Ile Leu Arg 
225                 230                 235                 240 


Pro Leu Tyr Arg Trp Lys Ile Lys Ser Arg Ser Arg Ala Ala Ile 
                245                 250                 255 


<210>  24
<211>  255
<212>  PRT
<213>  Ochrobactrum intermedium

<400>  24

Met Asn Glu Thr Arg Pro Asp Ile Thr Ala Ser Asp Gly Pro Gln Arg 
1               5                   10                  15      


Ala Val Lys Ala Phe Ile Ile His Leu Glu Arg Ala Thr Asp Arg Gln 
            20                  25                  30          


Pro Gln Val Glu Ala Leu Ile Arg Lys Leu Pro Ile Glu Thr Asp Val 
        35                  40                  45              


Val Asn Ala Val Asp Gly Arg Thr Leu Asp Ala Gln Thr Ile Ser Arg 
    50                  55                  60                  


Val Tyr Arg Arg Ser Ala His Lys Pro Arg Tyr Pro Phe Gln Leu Ser 
65                  70                  75                  80  


Thr Asn Glu Ile Ala Cys Phe Leu Ser His Arg Lys Ala Trp Gln Ala 
                85                  90                  95      


Ile Val Asp Gln Gly Leu Asp Ala Gly Leu Val Leu Glu Asp Asp Val 
            100                 105                 110         


Glu Leu Thr Pro Glu Phe Ala Ala Ala Tyr Ser Ala Ser Cys Gln Leu 
        115                 120                 125             


Leu Lys Ala His Ser Phe Ile Arg Phe Pro Phe Arg Glu Arg Glu Ser 
    130                 135                 140                 


Gly Arg Val Val Leu Thr Thr Glu Gly Val Arg Ile Ile Glu Pro Val 
145                 150                 155                 160 


Pro Val Gly Leu Gly Met Val Ala Gln Leu Val Gly Arg Glu Ala Ala 
                165                 170                 175     


Gln Arg Leu Leu Ser Ala Thr Glu Val Phe Asp Arg Pro Val Asp Thr 
            180                 185                 190         


Thr Ala Gln Met Asn Trp Val Thr Gly Leu Lys Pro Leu Ser Val Leu 
        195                 200                 205             


Pro Gly Gly Val Lys Glu Ile Ser Val Gln Leu Gly Gly Ser Thr Ile 
    210                 215                 220                 


Gln Lys Ser Arg Ser Leu Pro Asp Lys Leu Lys Arg Glu Ile Leu Arg 
225                 230                 235                 240 


Pro Leu Tyr Arg Trp Lys Ile Lys Ser Arg Ser Arg Ala Ala Val 
                245                 250                 255 


<210>  25
<211>  278
<212>  PRT
<213>  Agrobacterium radiobacter

<400>  25

Met Gln Thr Tyr Lys Ile Gly Phe Ser Ala Ala Ala Pro Leu Glu Arg 
1               5                   10                  15      


Ala His Ala Gly Leu Glu Pro Asp Gln Val Pro Leu Gly Thr Ile Asn 
            20                  25                  30          


Ala Arg Pro Ala Gln Ala Asn Ile Arg Gly Phe Ile Ile His Leu Asp 
        35                  40                  45              


Arg Ala Arg Asp Arg Leu Pro Gln Val Glu Arg Leu Ala Ala Met Leu 
    50                  55                  60                  


Pro Val Arg Ser Asp Ile Ile Gln Ala Val Asp Ala Ser Ala Phe Pro 
65                  70                  75                  80  


Asp Ala Asp Ile Asp Leu Val Tyr Arg Arg His Leu His Thr Pro Arg 
                85                  90                  95      


Tyr Pro Phe Glu Met Ser Val Gly Glu Ile Ala Cys Phe Leu Ser His 
            100                 105                 110         


Arg Lys Ala Trp Ala Ala Ile Val Glu Gln Gly Val Asp Ala Gly Leu 
        115                 120                 125             


Val Phe Glu Asp Asp Val Glu Ile Asp Ala Ser Phe His Ala Ala Phe 
    130                 135                 140                 


Ala Ala Ala Gln Ala Cys Leu Thr Pro Gly Ala Phe Ile Arg Phe Pro 
145                 150                 155                 160 


Phe Arg Met Gly Lys Glu His Gly Glu Cys Val Leu Thr His Gly Gln 
                165                 170                 175     


Ala Ser Val Ile Gln Pro Gly Arg Val Gly Leu Gly Met Val Ala Gln 
            180                 185                 190         


Leu Val Ser Arg Asp Ala Ala Ile Arg Leu Leu Glu Ala Thr Ala Leu 
        195                 200                 205             


Phe Asp Arg Pro Val Asp Thr Thr Val Gln Met Arg Trp Ile Thr Gly 
    210                 215                 220                 


Leu Ser Pro Leu Ala Val Leu Pro Gly Gly Val His Glu Ile Ser Ser 
225                 230                 235                 240 


Gln Leu Gly Gly Ser Thr Ile Lys Ser Arg Lys Thr Val Phe Glu Lys 
                245                 250                 255     


Leu Ser Arg Glu Ile Leu Arg Pro Leu Tyr Arg Ala Lys Ile Ala Ile 
            260                 265                 270         


Arg Ser Arg Arg Ser Ser 
        275             


<210>  26
<211>  252
<212>  PRT
<213>  Brucella melitensis 16M

<400>  26

Met Ile Gln Pro Ser Ile Thr Leu Ser Asn Val His Leu His Tyr Ala 
1               5                   10                  15      


Ala Ser Ala Phe Lys Glu Arg Ser Val Lys Thr Leu Val Asn Ala Leu 
            20                  25                  30          


Leu Ser Met Arg Arg Ser Ala Gly Ala Asn Ile Glu Asp Ile His Ala 
        35                  40                  45              


Leu Lys Gly Ile Ser Val Asp Ile Ala Arg Gly Glu Arg Val Ala Leu 
    50                  55                  60                  


Ile Gly His Asn Gly Ala Gly Lys Ser Thr Phe Leu Lys Thr Ile Ala 
65                  70                  75                  80  


Gly Leu Tyr Pro Ile Ser Ser Gly Thr Leu Lys Val Thr Gly Thr Val 
                85                  90                  95      


Arg Ser Leu Phe Asp Ile Gly Leu Gly Phe Glu Pro Asp Ala Thr Gly 
            100                 105                 110         


Arg Glu Asn Ile Leu Tyr Arg Gly Leu Leu Leu Gly Leu Thr Pro Arg 
        115                 120                 125             


Phe Met Arg Glu Ile Glu Asp Glu Ile Ile Glu Phe Ala Asp Leu Gly 
    130                 135                 140                 


Asp Phe Ile Asp Tyr Pro Ile Lys Thr Tyr Ser Ala Gly Met Gln Val 
145                 150                 155                 160 


Arg Leu Ala Phe Ala Ile Ser Thr Ala Val Asp Gly Asp Ile Leu Leu 
                165                 170                 175     


Leu Asp Glu Val Ile Gly Ala Gly Asp Ala Ala Phe Met Thr Lys Ala 
            180                 185                 190         


Lys Ala Arg Ile Met Asn Met Val Glu Lys Ala Glu Ile Met Val Leu 
        195                 200                 205             


Ala Ser His Asp Leu Ala Asn Val Arg Gln Leu Cys Thr Arg Ala Leu 
    210                 215                 220                 


Val Phe Lys Ala Gly Thr Ile Ala Phe Asp Gly Arg Val Glu Asp Ala 
225                 230                 235                 240 


Ile Ser Phe Tyr Asn Ser Gly Met Gly Ala Ile Ala 
                245                 250         


<210>  27
<211>  284
<212>  PRT
<213>  Brucella melitensis 16M

<400>  27

Met Ile Arg Asp Ser Gly Ala Pro Arg Arg Val Leu Trp Leu Leu Asn 
1               5                   10                  15      


His Thr Thr Leu Arg Glu Cys Glu Val Pro Leu Leu Gln Ser Met Gly 
            20                  25                  30          


Phe Glu Ile Phe Thr Pro Lys Arg Phe Pro Arg Asn Ser Asp Asn Arg 
        35                  40                  45              


Ser Ala Ser Val Ser Phe Glu Thr Asp Glu Ser Leu Thr Ile Pro Ala 
    50                  55                  60                  


Ser Val Ile Asp Glu Leu Asn Ser Tyr Asp Ser Tyr Gln Ala Pro Val 
65                  70                  75                  80  


Asn Pro Arg Ile Asp Phe Leu Ile Asn Tyr Tyr Phe Glu Asn Ala Ile 
                85                  90                  95      


Val Ala Tyr Met Phe Pro Met Phe Thr Gln Ile Ile Ser Arg Phe Lys 
            100                 105                 110         


Gly Arg Ile Leu Leu Arg Ala Phe Gly Leu Thr Ser Glu Thr Trp Thr 
        115                 120                 125             


Tyr Phe Asp Phe Ala Asn Phe Val Ala Gly Ser Phe Phe Lys Arg Thr 
    130                 135                 140                 


Trp Met Lys Ala Ser Asn Gln Phe Trp Phe Ala Ala Ser Tyr Ser Ser 
145                 150                 155                 160 


Leu Ile Glu Ile Glu Pro Asn Phe Ile Arg Glu Arg Thr Val Leu Leu 
                165                 170                 175     


Pro Val Gly Leu Pro Glu Arg Ile Leu Ala Lys Gln Asp Thr Trp Arg 
            180                 185                 190         


Gly Gly Asp Lys Arg Ile Met Phe Val Cys Pro Asp Ile Glu Thr Tyr 
        195                 200                 205             


Pro Glu Ala Lys Ala Ala Tyr Ser Glu Ser Lys His Val Phe Gly Asp 
    210                 215                 220                 


Leu Ser His Val Ile Cys Gly Asn Gln Thr Ile Pro Val Val Asp Asp 
225                 230                 235                 240 


Asp Asn Val Val Asp Arg Leu Ser Ala Glu Asp Gly Gly Arg Leu Pro 
                245                 250                 255     


Ile Ala Met Ser Cys Thr Asn Cys Ser Ala Asn Cys Thr Asn Val Thr 
            260                 265                 270         


Gln Val Gly Met Gln Ser Arg Val Ser Ile Tyr Ala 
        275                 280                 


<210>  28
<211>  259
<212>  PRT
<213>  Brucella melitensis 16M

<400>  28

Met Ala Ile Ala Pro Asn Thr Arg Val Leu Val Ala Gly Tyr Gly Leu 
1               5                   10                  15      


Pro Ala Glu Phe Cys Val Thr Thr Leu Ile Gly Met Gly Val Glu Ile 
            20                  25                  30          


Asp Lys Ile Ala Val Ala Thr His Arg Glu Asp Asn Arg Asn Cys Gly 
        35                  40                  45              


Leu His Ser Met Leu Arg Leu Arg Asn Ile Gln Phe Thr Thr Ala Ala 
    50                  55                  60                  


Ala Asn Ser Glu Glu Phe Tyr Glu Phe Gly Ala Asn Phe Asp Pro Asp 
65                  70                  75                  80  


Met Ile Ile Ser Met His Tyr Arg Ser Leu Ile Pro Gly Arg Phe Leu 
                85                  90                  95      


Lys Leu Ala Lys Lys Gly Ser Val Asn Leu His Pro Ser Leu Leu Pro 
            100                 105                 110         


Ala Tyr Arg Gly Thr Asn Ser Val Ala Trp Val Ile Ile Asn Gly Glu 
        115                 120                 125             


Ser Glu Thr Gly Phe Ser Tyr His Arg Met Asp Glu Asn Phe Asp Thr 
    130                 135                 140                 


Gly Ala Ile Leu Leu Gln Glu Arg Ile Ser Val Glu Glu Thr Asp Thr 
145                 150                 155                 160 


Ala Phe Ser Leu Phe His Arg Gln Ile Ala Arg Ala Met Leu Arg Leu 
                165                 170                 175     


Glu Glu Val Ile Leu Lys Leu Asp Gln Gly Asp Pro Gly Phe Ala Gln 
            180                 185                 190         


Leu Gly Glu Ala Ser Tyr Tyr Ala Arg Glu Leu Pro Phe Gly Gly Val 
        195                 200                 205             


Ile Asp Pro Arg Trp Ser Glu Val Gln Ile Asp Arg Phe Ile Arg Ala 
    210                 215                 220                 


Met Phe Phe Pro Pro Phe Pro Pro Ala Val Leu Lys Ile Asp Gly Lys 
225                 230                 235                 240 


Val Tyr Tyr Val Pro Ser Ile Asp Ile Tyr Arg Ser Leu Met Arg Gly 
                245                 250                 255     


Ile Pro Ser 
            


