                         SEQUENCE LISTING

<110>  Baylor Research Institute
       Banchereau, Jacques  F.
       Zurawski, Gerard
       Zurawski, Sandra
       Klechevsky, Eynav
       Oh, SangKon
 
<120>  VACCINES DIRECTED TO LANGERHANS CELLS

<130>  BHCS:2327

<140>  Concurrently Herewith.
<141>  2010-09-14

<150>  61/242,283
<151>  2009-09-14

<160>  80    

<170>  PatentIn version 3.5

<210>  1
<211>  1395
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide.

<400>  1
atggaatgga ggatctttct cttcatcctg tcaggaactg caggtgtcca ctcccaggtt       60

cagctgcggc agtctggacc tgagctggtg aagcctgggg cttcagtgaa gatgtcctgc      120

aaggcttctg gatacacatt tactgactat gttataagtt gggtgaagca gagaactgga      180

cagggccttg agtggattgg agatatttat cctggaagtg gttattcttt ctacaatgag      240

aacttcaagg gcaaggccac actgactgca gacaaatcct ccaccacagc ctacatgcag      300

ctcagcagcc tgacatctga ggactctgcg gtctatttct gtgcaaccta ctataactac      360

ccttttgctt actggggcca agggactctg gtcactgtct ctgcagccaa aacaacgggc      420

ccatccgtct tccccctggc gccctgctcc aggagcacct ccgagagcac agccgccctg      480

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      540

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      600

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcacga agacctacac ctgcaacgta      660

gatcacaagc ccagcaacac caaggtggac aagagagttg agtccaaata tggtccccca      720

tgcccaccct gcccagcacc tgagttcgaa gggggaccat cagtcttcct gttcccccca      780

aaacccaagg acactctcat gatctcccgg acccctgagg tcacgtgcgt ggtggtggac      840

gtgagccagg aagaccccga ggtccagttc aactggtacg tggatggcgt ggaggtgcat      900

aatgccaaga caaagccgcg ggaggagcag ttcaacagca cgtaccgtgt ggtcagcgtc      960

ctcaccgtcc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtctccaac     1020

aaaggcctcc cgtcctccat cgagaaaacc atctccaaag ccaaagggca gccccgagag     1080

ccacaggtgt acaccctgcc cccatcccag gaggagatga ccaagaacca ggtcagcctg     1140

acctgcctgg tcaaaggctt ctaccccagc gacatcgccg tggagtggga gagcaatggg     1200

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1260

ctctacagca ggctaaccgt ggacaagagc aggtggcagg aggggaatgt cttctcatgc     1320

tccgtgatgc atgaggctct gcacaaccac tacacacaga agagcctctc cctgtctctg     1380

ggtaaagcta gctga                                                      1395


<210>  2
<211>  446
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  2

Gln Val Gln Leu Arg Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Ser Gly Tyr Ser Phe Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Tyr Tyr Asn Tyr Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Lys Thr Thr Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Ser 
        435                 440                 445     


<210>  3
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Syntehtic oligonucleotide.

<400>  3
atggcctgga tttcacttat actctctctc ctggctctca gctcaggggc catttcccag       60

gctgttgtga ctcaggaatc tgcactcacc acatcacctg gtgaaacagt cacactcact      120

tgtcgctcaa gtactggggc tgttacaact agtaactatg ccaactgggt ccaagaaaaa      180

ccagatcatt tattcactgg tctaataggt ggtaccaaca accgagtttc aggtgttcct      240

gccagattct caggctccct gattggagac aaggctgccc tcaccatcac aggggcacag      300

actgaggatg aggcaatata tttctgtgct ctatggtaca gcaaccattg ggtgttcggt      360

ggaggaacca aactgactgt cctaggccag cccaagtctt cgccatcagt caccctgttt      420

ccaccttcct ctgaagagct cgagactaac aaggccacac tggtgtgtac gatcactgat      480

ttctacccag gtgtggtgac agtggactgg aaggtagatg gtacccctgt cactcagggt      540

atggagacaa cccagccttc caaacagagc aacaacaagt acatggctag cagctacctg      600

accctgacag caagagcatg ggaaaggcat agcagttaca gctgccaggt cactcatgaa      660

ggtcacactg tggagaagag tttgtcccgt gctgactgtt cctag                      705


<210>  4
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  4

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Val Ser Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro 
            100                 105                 110         


Lys Ser Ser Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu 
        115                 120                 125             


Glu Thr Asn Lys Ala Thr Leu Val Cys Thr Ile Thr Asp Phe Tyr Pro 
    130                 135                 140                 


Gly Val Val Thr Val Asp Trp Lys Val Asp Gly Thr Pro Val Thr Gln 
145                 150                 155                 160 


Gly Met Glu Thr Thr Gln Pro Ser Lys Gln Ser Asn Asn Lys Tyr Met 
                165                 170                 175     


Ala Ser Ser Tyr Leu Thr Leu Thr Ala Arg Ala Trp Glu Arg His Ser 
            180                 185                 190         


Ser Tyr Ser Cys Gln Val Thr His Glu Gly His Thr Val Glu Lys Ser 
        195                 200                 205             


Leu Ser Arg Ala Asp Cys Ser 
    210                 215 


<210>  5
<211>  1401
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide.

<400>  5
atgacattga acatgctgtt ggggctgaag tgggttttct ttgttgtttt ttatcaaggt       60

gtgcattgtg aggtgcagct tgttgagtct ggtggaggat tggtgcagcc taaagggtca      120

ttgaaactct catgtgcagc ctctggatta accttcaata tctacgccat gaactgggtc      180

cgccaggctc caggaaaggg tttggaatgg gttgctcgca taagaaataa aagtaataat      240

tatgcaacat attatgccga ttcagtgaaa gacaggttca ccatctccag agatgattca      300

caaagcttgc tctatctgca aatgaacaac ttgaaaactg aggacacagc catgtattac      360

tgtgtgggac gggactggtt tgattactgg ggccaaggga ctctggtcac tgtctctgca      420

gccaaaacga cacccccatc tgtctatcca ctggcccctg gatctgctgc ccaaactaac      480

tccatggtga ccctgggatg cctggtcaag ggctatttcc ctgagccagt gacagtgacc      540

tggaactctg gatccctgtc cagcggtgtg cacaccttcc cagctgtcct gcagtctgac      600

ctctacactc tgagcagctc agtgactgtc ccctccagca cctggcccag cgagaccgtc      660

acctgcaacg ttgcccaccc ggccagcagc accaaggtgg acaagaaaat tgtgcccagg      720

gattgtggtt gtaagccttg catatgtaca gtcccagaag tatcatctgt cttcatcttc      780

cccccaaagc ccaaggatgt gctcaccatt actctgactc ctaaggtcac gtgtgttgtg      840

gtagacatca gcaaggatga tcccgaggtc cagttcagct ggtttgtaga tgatgtggag      900

gtgcacacag ctcagacgca accccgggag gagcagttca acagcacttt ccgctcagtc      960

agtgaacttc ccatcatgca ccaggactgg ctcaatggca aggagttcaa atgcagggtc     1020

aacagtgcag ctttccctgc ccccatcgag aaaaccatct ccaaaaccaa aggcagaccg     1080

aaggctccac aggtgtacac cattccacct cccaaggagc agatggccaa ggataaagtc     1140

agtctgacct gcatgataac agacttcttc cctgaagaca ttactgtgga gtggcagtgg     1200

aatgggcagc cagcggagaa ctacaagaac actcagccca tcatggacac agatggctct     1260

tacttcgtct acagcaagct caatgtgcag aagagcaact gggaggcagg aaatactttc     1320

acctgctctg tgttacatga gggcctgcac aaccaccata ctgagaagag cctctcccac     1380

tctcctggta aagctagctg a                                               1401


<210>  6
<211>  443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  6

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Asn Ile Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Asn Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Leu 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Gly Arg Asp Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu 
        115                 120                 125             


Ala Pro Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser 
145                 150                 155                 160 


Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Asp Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp 
            180                 185                 190         


Pro Ser Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr 
        195                 200                 205             


Lys Val Asp Lys Lys Ile Val Pro Arg Asp Cys Gly Cys Lys Pro Cys 
    210                 215                 220                 


Ile Cys Thr Val Pro Glu Val Ser Ser Val Phe Ile Phe Pro Pro Lys 
225                 230                 235                 240 


Pro Lys Asp Val Leu Thr Ile Thr Leu Thr Pro Lys Val Thr Cys Val 
                245                 250                 255     


Val Val Asp Ile Ser Lys Asp Asp Pro Glu Val Gln Phe Ser Trp Phe 
            260                 265                 270         


Val Asp Asp Val Glu Val His Thr Ala Gln Thr Gln Pro Arg Glu Glu 
        275                 280                 285             


Gln Phe Asn Ser Thr Phe Arg Ser Val Ser Glu Leu Pro Ile Met His 
    290                 295                 300                 


Gln Asp Trp Leu Asn Gly Lys Glu Phe Lys Cys Arg Val Asn Ser Ala 
305                 310                 315                 320 


Ala Phe Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys Gly Arg 
                325                 330                 335     


Pro Lys Ala Pro Gln Val Tyr Thr Ile Pro Pro Pro Lys Glu Gln Met 
            340                 345                 350         


Ala Lys Asp Lys Val Ser Leu Thr Cys Met Ile Thr Asp Phe Phe Pro 
        355                 360                 365             


Glu Asp Ile Thr Val Glu Trp Gln Trp Asn Gly Gln Pro Ala Glu Asn 
    370                 375                 380                 


Tyr Lys Asn Thr Gln Pro Ile Met Asp Thr Asp Gly Ser Tyr Phe Val 
385                 390                 395                 400 


Tyr Ser Lys Leu Asn Val Gln Lys Ser Asn Trp Glu Ala Gly Asn Thr 
                405                 410                 415     


Phe Thr Cys Ser Val Leu His Glu Gly Leu His Asn His His Thr Glu 
            420                 425                 430         


Lys Ser Leu Ser His Ser Pro Gly Lys Ala Ser 
        435                 440             


<210>  7
<211>  1635
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Syntehtic oligonucleotide.

<400>  7
atgacattga acatgctgtt ggggctgagg tgggttttct ttgttgtttt ttatcaaggt       60

gtgcattgtg aggtgcagct tgttgagtct ggtggaggat tggtgcagcc taaagggtca      120

ttgaaactct catgtgcagc ctctggatta accttcaata tctacgccat gaactgggtc      180

cgccaggctc caggaaaggg tttggaatgg gttgctcgca taagaaataa aagtaataat      240

tatgcaacat attatgccga ttcagtgaaa gacaggttca ccatctccag agatgattca      300

caaagcttgc tctatctgca aatgaacaac ttgaaaactg aggacacagc catgtattac      360

tgtgtgggac gggactggtt tgattactgg ggccaaggga ctctggtcac tgtctctgca      420

gccaaaacga agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag      480

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      540

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      660

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      720

aaatatggtc ccccatgccc accctgccca gcacctgagt tcgaaggggg accatcagtc      780

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      840

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa     1080

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg     1320

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc     1380

ctctccctgt ctctgggtaa agctagcaat tctcctcaaa atgaagtact gtacggagat     1440

gtgaatgatg acggaaaagt aaactccact gacttgactt tgttaaaaag atatgttctt     1500

aaagccgtct caactctccc ttcttccaaa gctgaaaaga acgcagatgt aaatcgtgac     1560

ggaagagtta attccagtga tgtcacaata ctttcaagat atttgataag ggtaatcgag     1620

aaattaccaa tataa                                                      1635


<210>  8
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  8

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Asn Ile Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Asn Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Leu 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Gly Arg Asp Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Lys Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Ser Asn Ser 
        435                 440                 445             


Pro Gln Asn Glu Val Leu Tyr Gly Asp Val Asn Asp Asp Gly Lys Val 
    450                 455                 460                 


Asn Ser Thr Asp Leu Thr Leu Leu Lys Arg Tyr Val Leu Lys Ala Val 
465                 470                 475                 480 


Ser Thr Leu Pro Ser Ser Lys Ala Glu Lys Asn Ala Asp Val Asn Arg 
                485                 490                 495     


Asp Gly Arg Val Asn Ser Ser Asp Val Thr Ile Leu Ser Arg Tyr Leu 
            500                 505                 510         


Ile Arg Val Ile Glu Lys Leu Pro Ile 
        515                 520     


<210>  9
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  9

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val 
    50                  55                  60  


<210>  10
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Syhthetic peptide.

<400>  10

Leu Thr Ala Ala His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly 
1               5                   10                  15      


Arg His Ser Leu Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val 
            20                  25                  30          


Ser His Ser Phe Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn 
        35                  40                  45              


Arg Phe Leu Arg Pro Gly Asp Asp Ser Ser His Asp 
    50                  55                  60  


<210>  11
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  11

Leu Met Leu Leu Arg Leu Ser Glu Pro Ala Glu Leu Thr Asp Ala Val 
1               5                   10                  15      


Lys Val Met Asp Leu Pro Thr Gln Glu Pro Ala Leu Gly Thr Thr Cys 
            20                  25                  30          


Tyr Ala Ser Gly Trp Gly Ser Ile Glu Pro Glu Glu Phe Leu Thr Pro 
        35                  40                  45              


Lys Lys Leu Gln Cys Val Asp Leu His Val Ile Ser 
    50                  55                  60  


<210>  12
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  12

Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val Thr Lys Phe Met 
1               5                   10                  15      


Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr Cys Ser Gly Asp 
            20                  25                  30          


Ser Gly Gly Pro Leu Val Cys Asn Gly Val Leu Gln Gly Ile Thr Ser 
        35                  40                  45              


Trp Gly Ser Glu Pro Cys Ala Leu Pro Glu Arg Pro 
    50                  55                  60  


<210>  13
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  13

Ser Leu Tyr Thr Lys Val Val His Tyr Arg Lys Trp Ile Lys Asp Thr 
1               5                   10                  15      


Ile Val Ala Asn Pro 
            20      


<210>  14
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  14

Ile Met Asp Gln Val Pro Phe Ser Val 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  15

Ile Thr Asp Gln Val Pro Phe Ser Val 
1               5                   


<210>  16
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  16

Tyr Leu Glu Pro Gly Pro Val Thr Val 
1               5                   


<210>  17
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  17

Tyr Leu Glu Pro Gly Pro Val Thr Ala 
1               5                   


<210>  18
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Syntehtic peptide.

<400>  18

Lys Thr Trp Gly Gln Tyr Trp Gln Val 
1               5                   


<210>  19
<211>  244
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  19

Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu Lys 
1               5                   10                  15      


His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala Val 
            20                  25                  30          


Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala His 
        35                  40                  45              


Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu Phe 
    50                  55                  60                  


His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe Pro 
65                  70                  75                  80  


His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg Pro 
                85                  90                  95      


Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu Pro 
            100                 105                 110         


Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln Glu 
        115                 120                 125             


Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile Glu 
    130                 135                 140                 


Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu His 
145                 150                 155                 160 


Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val Thr 
                165                 170                 175     


Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr Cys 
            180                 185                 190         


Ser Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Gly Val Leu Gln Gly 
        195                 200                 205             


Ile Thr Ser Trp Gly Ser Glu Pro Cys Ala Leu Pro Glu Arg Pro Ser 
    210                 215                 220                 


Leu Tyr Thr Lys Val Val His Tyr Arg Lys Trp Ile Lys Asp Thr Ile 
225                 230                 235                 240 


Val Ala Asn Pro 
                


<210>  20
<211>  230
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  20

Asp Thr Thr Glu Pro Ala Thr Pro Thr Thr Pro Val Thr Thr Pro Thr 
1               5                   10                  15      


Thr Thr Lys Val Pro Arg Asn Gln Asp Trp Leu Gly Val Ser Arg Gln 
            20                  25                  30          


Leu Arg Thr Lys Ala Trp Asn Arg Gln Leu Tyr Pro Glu Trp Thr Glu 
        35                  40                  45              


Ala Gln Arg Leu Asp Cys Trp Arg Gly Gly Gln Val Ser Leu Lys Val 
    50                  55                  60                  


Ser Asn Asp Gly Pro Thr Leu Ile Gly Ala Asn Ala Ser Phe Ser Ile 
65                  70                  75                  80  


Ala Leu Asn Phe Pro Gly Ser Gln Lys Val Leu Pro Asp Gly Gln Val 
                85                  90                  95      


Ile Trp Val Asn Asn Thr Ile Ile Asn Gly Ser Gln Val Trp Gly Gly 
            100                 105                 110         


Gln Pro Val Tyr Pro Gln Glu Thr Asp Asp Ala Cys Ile Phe Pro Asp 
        115                 120                 125             


Gly Gly Pro Cys Pro Ser Gly Ser Trp Ser Gln Lys Arg Ser Phe Val 
    130                 135                 140                 


Tyr Val Trp Lys Thr Trp Gly Gln Tyr Trp Gln Val Leu Gly Gly Pro 
145                 150                 155                 160 


Val Ser Gly Leu Ser Ile Gly Thr Gly Arg Ala Met Leu Gly Thr His 
                165                 170                 175     


Thr Met Glu Val Thr Val Tyr His Arg Arg Gly Ser Gln Ser Tyr Val 
            180                 185                 190         


Pro Leu Ala His Ser Ser Ser Ala Phe Thr Ile Thr Asp Gln Val Pro 
        195                 200                 205             


Phe Ser Val Ser Val Ser Gln Leu Arg Ala Leu Asp Gly Gly Asn Lys 
    210                 215                 220                 


His Phe Leu Arg Asn Gln 
225                 230 


<210>  21
<211>  73
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.


<220>
<221>  misc_feature
<222>  (38)..(38)
<223>  Xaa can be any naturally occurring amino acid

<400>  21

Pro Leu Thr Phe Ala Leu Gln Leu His Asp Pro Ser Gly Tyr Leu Ala 
1               5                   10                  15      


Glu Ala Asp Leu Ser Tyr Thr Trp Asp Phe Gly Asp Ser Ser Gly Thr 
            20                  25                  30          


Leu Ile Ser Arg Ala Xaa Val Val Thr His Thr Tyr Leu Glu Pro Gly 
        35                  40                  45              


Pro Val Thr Ala Gln Val Val Leu Gln Ala Ala Ile Pro Leu Thr Ser 
    50                  55                  60                  


Cys Gly Ser Ser Pro Val Pro Ala Ser 
65                  70              


<210>  22
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  22

Gly Thr Thr Asp Gly His Arg Pro Thr Ala Glu Ala Pro Asn Thr Thr 
1               5                   10                  15      


Ala Gly Gln Val Pro Thr Thr Glu Val Val Gly Thr Thr Pro Gly Gln 
            20                  25                  30          


Ala Pro Thr Ala Glu Pro Ser Gly Thr Thr Ser Val Gln Val Pro Thr 
        35                  40                  45              


Thr Glu Val Ile Ser Thr Ala Pro Val Gln Met Pro Thr Ala Glu Ser 
    50                  55                  60                  


Thr Gly Met Thr Pro Glu Lys Val Pro Val Ser Glu Val Met Gly Thr 
65                  70                  75                  80  


Thr Leu Ala Glu Met Ser Thr Pro Glu Ala Thr Gly Met Thr Pro Ala 
                85                  90                  95      


Glu Val Ser Ile Val Val Leu Ser Gly Thr Thr Ala Ala 
            100                 105                 


<210>  23
<211>  75
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  23

Gln Val Thr Thr Thr Glu Trp Val Glu Thr Thr Ala Arg Glu Leu Pro 
1               5                   10                  15      


Ile Pro Glu Pro Glu Gly Pro Asp Ala Ser Ser Ile Met Ser Thr Glu 
            20                  25                  30          


Ser Ile Thr Gly Ser Leu Gly Pro Leu Leu Asp Gly Thr Ala Thr Leu 
        35                  40                  45              


Arg Leu Val Lys Arg Gln Val Pro Leu Asp Cys Val Leu Tyr Arg Tyr 
    50                  55                  60                  


Gly Ser Phe Ser Val Thr Leu Asp Ile Val Gln 
65                  70                  75  


<210>  24
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  24

Gly Ile Glu Ser Ala Glu Ile Leu Gln Ala Val Pro Ser Gly Glu Gly 
1               5                   10                  15      


Asp Ala Phe Glu Leu Thr Val Ser Cys Gln Gly Gly Leu Pro Lys Glu 
            20                  25                  30          


Ala Cys Met Glu Ile Ser Ser Pro Gly Cys Gln Pro Pro Ala Gln Arg 
        35                  40                  45              


Leu Cys Gln Pro Val Leu Pro Ser Pro Ala Cys Gln Leu Val Leu His 
    50                  55                  60                  


Gln Ile Leu Lys Gly Gly Ser Gly Thr Tyr Cys Leu Asn Val Ser Leu 
65                  70                  75                  80  


Ala Asp Thr Asn Ser Leu Ala Val Val Ser Thr Gln Leu Ile Val Pro 
                85                  90                  95      


Gly Ile Leu Leu Thr Gly Gln Glu Ala Gly Leu Gly Gln 
            100                 105                 


<210>  25
<211>  50
<212>  PRT
<213>  ARtificial Sequence

<220>
<223>  Synthetic peptide.

<400>  25

Met Glu Met Lys Ile Leu Arg Ala Leu Asn Phe Gly Leu Gly Arg Pro 
1               5                   10                  15      


Leu Pro Leu His Phe Leu Arg Arg Ala Ser Lys Ile Gly Glu Val Asp 
            20                  25                  30          


Val Glu Gln His Thr Leu Ala Lys Tyr Leu Met Glu Leu Thr Met Leu 
        35                  40                  45              


Asp Tyr 
    50  


<210>  26
<211>  36
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  26

Asp Trp Leu Val Gln Val Gln Met Lys Phe Arg Leu Leu Gln Glu Thr 
1               5                   10                  15      


Met Tyr Met Thr Val Ser Ile Ile Asp Arg Phe Met Gln Asn Asn Cys 
            20                  25                  30          


Val Pro Lys Lys 
        35      


<210>  27
<211>  48
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Syntehtic peptide.

<400>  27

Met Glu His Gln Leu Leu Cys Cys Glu Val Glu Thr Ile Arg Arg Ala 
1               5                   10                  15      


Tyr Pro Asp Ala Asn Leu Leu Asn Asp Arg Val Leu Arg Ala Met Leu 
            20                  25                  30          


Lys Ala Glu Glu Thr Cys Ala Pro Ser Val Ser Tyr Phe Lys Cys Val 
        35                  40                  45              


<210>  28
<211>  95
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  28

Gln Lys Glu Val Leu Pro Ser Met Arg Lys Ile Val Ala Thr Trp Met 
1               5                   10                  15      


Leu Glu Val Cys Glu Glu Gln Lys Cys Glu Glu Glu Val Phe Pro Leu 
            20                  25                  30          


Ala Met Asn Tyr Leu Asp Arg Phe Leu Ser Leu Glu Pro Val Lys Lys 
        35                  40                  45              


Ser Arg Leu Gln Leu Leu Gly Ala Thr Cys Met Phe Val Ala Ser Lys 
    50                  55                  60                  


Met Lys Glu Thr Ile Pro Leu Thr Ala Glu Lys Leu Cys Ile Tyr Thr 
65                  70                  75                  80  


Asp Asn Ser Ile Arg Pro Glu Glu Leu Leu Gln Met Glu Leu Leu 
                85                  90                  95  


<210>  29
<211>  60
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  29

Leu Val Asn Lys Leu Lys Trp Asn Leu Ala Ala Met Thr Pro His Asp 
1               5                   10                  15      


Phe Ile Glu His Phe Leu Ser Lys Met Pro Glu Ala Glu Glu Asn Lys 
            20                  25                  30          


Gln Ile Ile Arg Lys His Ala Gln Thr Phe Val Ala Leu Cys Ala Thr 
        35                  40                  45              


Asp Val Lys Phe Ile Ser Asn Pro Pro Ser Met Val 
    50                  55                  60  


<210>  30
<211>  92
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  30

Ala Ala Gly Ser Val Val Ala Ala Val Gln Gly Leu Asn Leu Arg Ser 
1               5                   10                  15      


Pro Asn Asn Phe Leu Ser Tyr Tyr Arg Leu Thr Arg Phe Leu Ser Arg 
            20                  25                  30          


Val Ile Lys Cys Asp Pro Asp Cys Leu Arg Ala Cys Gln Glu Gln Ile 
        35                  40                  45              


Glu Ala Leu Leu Glu Ser Ser Leu Arg Gln Ala Gln Gln Asn Met Asp 
    50                  55                  60                  


Pro Lys Ala Ala Glu Glu Glu Glu Glu Glu Glu Glu Glu Val Asp Leu 
65                  70                  75                  80  


Ala Cys Thr Pro Thr Asp Val Arg Asp Val Asp Ile 
                85                  90          


<210>  31
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  31

Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro Met Thr Tyr 
1               5                   10                  15      


Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys Gly Gly Leu 
            20                  25                  30          


<210>  32
<211>  30
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  32

His Thr Gln Gly Tyr Phe Pro Asp Trp Gln Asn Tyr Thr Pro Gly Pro 
1               5                   10                  15      


Gly Val Arg Tyr Pro Leu Thr Phe Gly Trp Leu Tyr Lys Leu 
            20                  25                  30  


<210>  33
<211>  19
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  33

Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys 
1               5                   10                  15      


His Ile Val 
            


<210>  34
<211>  32
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Syntehtic peptide.

<400>  34

Asn Pro Pro Ile Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu 
1               5                   10                  15      


Gly Leu Asn Lys Ile Val Arg Met Tyr Ser Pro Thr Ser Ile Leu Asp 
            20                  25                  30          


<210>  35
<211>  31
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Syntehtic peptide.

<400>  35

Ala Ile Phe Gln Ser Ser Met Thr Lys Ile Leu Glu Pro Phe Arg Lys 
1               5                   10                  15      


Gln Asn Pro Asp Ile Val Ile Tyr Gln Tyr Met Asp Asp Leu Tyr 
            20                  25                  30      


<210>  36
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Syntehtic peptide.

<400>  36

Asp Thr Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr Val 
1               5                   10                  15      


Asp Thr Val Leu Glu Lys Asn Val Thr Val Thr His Ser Val Asn Leu 
            20                  25                  30          


Leu Glu Asp Ser His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile Ala 
        35                  40                  45              


Pro Leu Gln Leu Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly Asn 
    50                  55                  60                  


Pro Glu Cys Asp Pro Leu Leu Pro Val Arg Ser Trp Ser Tyr Ile Val 
65                  70                  75                  80  


Glu Thr Pro Asn Ser Glu Asn Gly Ile Cys Tyr Pro Gly Asp Phe Ile 
                85                  90                  95      


Asp Tyr Glu Glu Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe Glu 
            100                 105                 110         


Arg Phe Glu Ile Phe Pro Lys Glu Ser Ser Trp Pro Asn His Asn Thr 
        115                 120                 125             


Asn Gly Val Thr Ala Ala Cys Ser His Glu Gly Lys Ser Ser Phe Tyr 
    130                 135                 140                 


Arg Asn Leu Leu Trp Leu Thr Glu Lys Glu Gly Ser Tyr Pro Lys Leu 
145                 150                 155                 160 


Lys Asn Ser Tyr Val Asn Lys Lys Gly Lys Glu Val Leu Val Leu Trp 
                165                 170                 175     


Gly Ile His His Pro Pro Asn Ser Lys Glu Gln Gln Asn Leu Tyr Gln 
            180                 185                 190         


Asn Glu Asn Ala Tyr Val Ser Val Val Thr Ser Asn Tyr Asn Arg Arg 
        195                 200                 205             


Phe Thr Pro Glu Ile Ala Glu Arg Pro Lys Val Arg Asp Gln Ala Gly 
    210                 215                 220                 


Arg Met Asn Tyr Tyr Trp Thr Leu Leu Lys Pro Gly Asp Thr Ile Ile 
225                 230                 235                 240 


Phe Glu Ala Asn Gly Asn Leu Ile Ala Pro Met Tyr Ala Phe Ala Leu 
                245                 250                 255     


Ser Arg Gly Phe Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser Met His 
            260                 265                 270         


Glu Cys Asn Thr Lys Cys Gln Thr Pro Leu Gly Ala Ile Asn Ser Ser 
        275                 280                 285             


Leu Pro Tyr Gln Asn Ile His Pro Val Thr Ile Gly Glu Cys Pro Lys 
    290                 295                 300                 


Tyr Val Arg Ser Ala Lys Leu Arg Met Val 
305                 310                 


<210>  37
<211>  314
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Syntehtic peptide.

<400>  37

Asp Gln Ile Cys Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val 
1               5                   10                  15      


Asp Thr Ile Met Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile 
            20                  25                  30          


Leu Glu Lys Lys His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys 
        35                  40                  45              


Pro Leu Ile Leu Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn 
    50                  55                  60                  


Pro Met Cys Asp Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val 
65                  70                  75                  80  


Glu Lys Ala Asn Pro Val Asn Asp Leu Cys Tyr Pro Gly Asp Phe Asn 
                85                  90                  95      


Asp Tyr Glu Glu Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu 
            100                 105                 110         


Lys Ile Gln Ile Ile Pro Lys Ser Ser Trp Ser Ser His Glu Ala Ser 
        115                 120                 125             


Leu Gly Val Ser Ser Ala Cys Pro Tyr Gln Gly Lys Ser Ser Phe Phe 
    130                 135                 140                 


Arg Asn Val Val Trp Leu Ile Lys Lys Asn Ser Thr Tyr Pro Thr Ile 
145                 150                 155                 160 


Lys Arg Ser Tyr Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp 
                165                 170                 175     


Gly Ile His His Pro Asn Asp Ala Ala Glu Gln Thr Lys Leu Tyr Gln 
            180                 185                 190         


Asn Pro Thr Thr Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg 
        195                 200                 205             


Leu Val Pro Arg Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly 
    210                 215                 220                 


Arg Met Glu Phe Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn 
225                 230                 235                 240 


Phe Glu Ser Asn Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile 
                245                 250                 255     


Val Lys Lys Gly Asp Ser Thr Ile Met Lys Ser Glu Leu Glu Tyr Gly 
            260                 265                 270         


Asn Cys Asn Thr Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser 
        275                 280                 285             


Met Pro Phe His Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys 
    290                 295                 300                 


Tyr Val Lys Ser Asn Arg Leu Val Leu Ala 
305                 310                 


<210>  38
<211>  231
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Syntehtic peptide.

<400>  38

Pro Ile Val Gln Asn Ile Gln Gly Gln Met Val His Gln Ala Ile Ser 
1               5                   10                  15      


Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu Glu Lys Ala Phe 
            20                  25                  30          


Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser Glu Gly Ala Thr 
        35                  40                  45              


Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly Gly His Gln Ala 
    50                  55                  60                  


Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu Ala Ala Glu Trp 
65                  70                  75                  80  


Asp Arg Val His Pro Val His Ala Gly Pro Ile Ala Pro Gly Gln Met 
                85                  90                  95      


Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr Ser Thr Leu Gln 
            100                 105                 110         


Glu Gln Ile Gly Trp Met Thr Asn Asn Pro Pro Ile Pro Val Gly Glu 
        115                 120                 125             


Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys Ile Val Arg Met 
    130                 135                 140                 


Tyr Ser Pro Thr Ser Ile Leu Asp Ile Arg Gln Gly Pro Lys Glu Pro 
145                 150                 155                 160 


Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu Arg Ala Glu Gln 
                165                 170                 175     


Ala Ser Gln Glu Val Lys Asn Trp Met Thr Glu Thr Leu Leu Val Gln 
            180                 185                 190         


Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala Leu Gly Pro Ala 
        195                 200                 205             


Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly Val Gly Gly Pro 
    210                 215                 220                 


Gly His Lys Ala Arg Val Leu 
225                 230     


<210>  39
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  39

Ser Ser Val Ser Pro Thr Thr Ser Val His Pro Thr Pro Thr Ser Val 
1               5                   10                  15      


Pro Pro Thr Pro Thr Lys Ser Ser Pro 
            20                  25  


<210>  40
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  40

Pro Thr Ser Thr Pro Ala Asp Ser Ser Thr Ile Thr Pro Thr Ala Thr 
1               5                   10                  15      


Pro Thr Ala Thr Pro Thr Ile Lys Gly 
            20                  25  


<210>  41
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  41

Thr Val Thr Pro Thr Ala Thr Ala Thr Pro Ser Ala Ile Val Thr Thr 
1               5                   10                  15      


Ile Thr Pro Thr Ala Thr Thr Lys Pro 
            20                  25  


<210>  42
<211>  25
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  42

Thr Asn Gly Ser Ile Thr Val Ala Ala Thr Ala Pro Thr Val Thr Pro 
1               5                   10                  15      


Thr Val Asn Ala Thr Pro Ser Ala Ala 
            20                  25  


<210>  43
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  43

Gly Ile Leu Gly Phe Val Phe Thr Leu 
1               5                   


<210>  44
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  44

Lys Leu Gln Cys Val Asp Leu His Val 
1               5                   


<210>  45
<211>  76
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  45

Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser Asn Gly 
1               5                   10                  15      


Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser Pro Lys 
            20                  25                  30          


Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro Asp Arg 
        35                  40                  45              


Phe Ser Gly Ser Gly Ser Gly Thr Asn Phe Thr Leu Lys Ile Ser Arg 
    50                  55                  60                  


Val Glu Ala Glu Asp Leu Gly Leu Tyr Phe Cys Ser 
65                  70                  75      


<210>  46
<211>  81
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  46

Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
1               5                   10                  15      


Val Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
            20                  25                  30          


Gly Asp Ile Tyr Pro Gly Ser Gly Tyr Ser Phe Tyr Asn Glu Asn Phe 
        35                  40                  45              


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
    50                  55                  60                  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
65                  70                  75                  80  


Ala 
    


<210>  47
<211>  74
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  47

Val Thr Leu Thr Cys Arg Ser Ser Thr Gly Ala Val Thr Thr Ser Asn 
1               5                   10                  15      


Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly Leu 
            20                  25                  30          


Ile Gly Gly Thr Asn Asn Arg Val Ser Gly Val Pro Ala Arg Phe Ser 
        35                  40                  45              


Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala Gln 
    50                  55                  60                  


Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala 
65                  70                  


<210>  48
<211>  82
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  48

Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Asn Ile Tyr 
1               5                   10                  15      


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
            20                  25                  30          


Ala Arg Ile Arg Asn Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
        35                  40                  45              


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Leu 
    50                  55                  60                  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
65                  70                  75                  80  


Tyr Cys 
        


<210>  49
<211>  717
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Syntehtic oligonucleotide.

<400>  49
atgaagttgc ctgttaggct gttggtgctg atgttctgga ttcctgcttc cagcagtgat       60

gttgtgatga cccaaactcc actctccctg cctgtccgtc ttggagatca agcctccatc      120

tcttgcagat ctagtcagag ccttgtacac agtaatggaa acacctattt acattggtac      180

ctgcagaagc caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct      240

ggggtcccag acaggttcag tggcagtgga tcagggacaa atttcacact caagatcagc      300

agagtggagg ctgaggatct gggactttat ttctgctctc aaagtacaca tgttccgtac      360

acgttcggag gggggaccaa gctggaaata aaacgggctg atgctgcacc aactgtatcc      420

atcttcccac catccagtga gcagttaaca tctggaggtg cctcagtcgt gtgcttcttg      480

aacaacttct accccaaaga catcaatgtc aagtggaaga ttgatggcag tgaacgacaa      540

aatggcgtcc tgaacagttg gactgatcag gacagcaaag acagcaccta cagcatgaac      600

agcaccctca cgttgaccaa ggacgagtat gaacgacata acagctatac ctgtgaggcc      660

actcacaaga catcaacttc acccatcgtc aagagcttca acaggaatga gtgttag         717


<210>  50
<211>  219
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Syntehtic peptide.

<400>  50

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Arg Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asn Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asn Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Leu Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu 
        115                 120                 125             


Gln Leu Thr Ser Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Lys Asp Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg 
145                 150                 155                 160 


Gln Asn Gly Val Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Met Asn Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu 
            180                 185                 190         


Arg His Asn Ser Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser 
        195                 200                 205             


Pro Ile Val Lys Ser Phe Asn Arg Asn Glu Cys 
    210                 215                 


<210>  51
<211>  714
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide.

<400>  51
atggattttc agatgcagat tatcagcttg ctgctaatca gtgtcacagt catagtgtct       60

aatggagaaa ttgtgctcac ccagtctcca accaccatgg ctgcatctcc cggggagaag      120

atcactatca cctgcagtgc cagctcaagt ataagttccc attacttaca ttggtatcag      180

cagaagccag gattctcccc taaactcttg atttatagga catccaatct ggcttctgga      240

gtcccagctc gcttcagtgg cagtgggtct gggacctctt actctctcac aattgacacc      300

atggaggctg aagatgttgc cacttactac tgccagcagg gtagtagtat accattcacg      360

ttcggctcgg ggacaaagtt ggaaataaaa cgggctgatg ctgcaccaac tgtatccatc      420

ttcccaccat ccagtgagca gttaacatct ggaggtgcct cagtcgtgtg cttcttgaac      480

aacttctacc ccaaagacat caatgtcaag tggaagattg atggcagtga acgacaaaat      540

ggcgtcctga acagttggac tgatcaggac agcaaagaca gcacctacag catgagcagc      600

accctcacgt tgaccaagga cgagtatgaa cgacataaca gctatacctg tgaggccact      660

cacaagacat caacttcacc catcgtcaag agcttcaaca ggaatgagtg ttag            714


<210>  52
<211>  215
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  52

Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Ile Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Ser His 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Phe Ser Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Arg Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Asp Thr Met Glu 
65                  70                  75                  80  


Ala Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Gly Ser Ser Ile Pro 
                85                  90                  95      


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala 
            100                 105                 110         


Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser 
        115                 120                 125             


Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp 
    130                 135                 140                 


Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val 
145                 150                 155                 160 


Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser 
            180                 185                 190         


Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys 
        195                 200                 205             


Ser Phe Asn Arg Asn Glu Cys 
    210                 215 


<210>  53
<211>  1479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide.

<400>  53
atgagatcac tgttctcttt acagttactg agcacacagg acctcgccat gggatggagc       60

tgtatcatcc tcttcttggt agcaacagct acaggtgtcc actctcaggt ccaactgcag      120

cagcctgggg ctgaacttgt gaagcctggg gcttcagtga agctgtcctg caaggcttct      180

ggctacacct tcaccagtta ctggatgcag tgggtaaagc agaggcctgg acagggcctt      240

gagtggatcg gagagattga tccttctgat agctatacta actacaatca aaggttcaag      300

ggcaaggcca cattgactgt ggacacatcc tccagcacag cctacataca gctcagcagc      360

ctgacgtctg aggactctgc ggtctgtttc tgtgcaagac gctactatgg taactacgat      420

gggtttgctt actggggcca agggactctg gtcactgtct ctgcagccaa aacaacagcc      480

ccatcggtct atccactggc ccctgtgtgt ggaggtacaa ctggctcctc ggtgactcta      540

ggatgcctgg tcaagggtta tttccctgag ccagtgacct tgacctggaa ctctggatcc      600

ctgtccagtg gtgtgcacac cttcccagct ctcctgcagt ctggcctcta caccctcagc      660

agctcagtga ctgtaacctc gaacacctgg cccagccaga ccatcacctg caatgtggcc      720

cacccggcaa gcagcaccaa agtggacaag aaaattgagc ccagagtgcc cataacacag      780

aacccctgtc ctccactcaa agagtgtccc ccatgcgcag ctccagacct cttgggtgga      840

ccatccgtct tcatcttccc tccaaagatc aaggatgtac tcatgatctc cccgagcccc      900

atggtcacat gtgtggtggt ggatgtgagc gaggatgacc cagacgtcca gatcagctgg      960

tttgtgaaca acgtggaagt acacacagct cagacacaaa cccatagaga ggattacaac     1020

agtactctcc gggtggtcag tgccctcccc atccagcacc aggactggat gagtggcaag     1080

gagttcaaat gcaaggtcaa caacagagcc ctcccatccc ccatcgagaa aaccatctca     1140

aaacccagag ggccagtaag agctccacag gtatatgtct tgcctccacc agcagaagag     1200

atgactaaga aagagttcag tctgacctgc atgatcacag gcttcttacc tgccgaaatt     1260

gctgtggact ggaccagcaa tgggcgtaca gagcaaaact acaagaacac cgcaacagtc     1320

ctggactctg atggttctta cttcatgtac agcaagctca gagtacaaaa gagcacttgg     1380

gaaagaggaa gtcttttcgc ctgctcagtg gtccacgagg gtctgcacaa tcaccttacg     1440

actaagacca tctcccggtc tctgggtaaa gctagctga                            1479


<210>  54
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  54

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Ile Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Cys Phe Cys 
                85                  90                  95      


Ala Arg Arg Tyr Tyr Gly Asn Tyr Asp Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Tyr Pro Leu Ala Pro Val Cys Gly Gly Thr Thr Gly Ser Ser Val Thr 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Leu 
                165                 170                 175     


Leu Gln Ser Gly Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser 
            180                 185                 190         


Asn Thr Trp Pro Ser Gln Thr Ile Thr Cys Asn Val Ala His Pro Ala 
        195                 200                 205             


Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Val Pro Ile Thr 
    210                 215                 220                 


Gln Asn Pro Cys Pro Pro Leu Lys Glu Cys Pro Pro Cys Ala Ala Pro 
225                 230                 235                 240 


Asp Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys 
                245                 250                 255     


Asp Val Leu Met Ile Ser Pro Ser Pro Met Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn 
        275                 280                 285             


Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr 
    290                 295                 300                 


Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp 
305                 310                 315                 320 


Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Arg Ala Leu 
                325                 330                 335     


Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Pro Arg Gly Pro Val Arg 
            340                 345                 350         


Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Ala Glu Glu Met Thr Lys 
        355                 360                 365             


Lys Glu Phe Ser Leu Thr Cys Met Ile Thr Gly Phe Leu Pro Ala Glu 
    370                 375                 380                 


Ile Ala Val Asp Trp Thr Ser Asn Gly Arg Thr Glu Gln Asn Tyr Lys 
385                 390                 395                 400 


Asn Thr Ala Thr Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser 
                405                 410                 415     


Lys Leu Arg Val Gln Lys Ser Thr Trp Glu Arg Gly Ser Leu Phe Ala 
            420                 425                 430         


Cys Ser Val Val His Glu Gly Leu His Asn His Leu Thr Thr Lys Thr 
        435                 440                 445             


Ile Ser Arg Ser Leu Gly Lys Ala Ser 
    450                 455         


<210>  55
<211>  705
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide.

<400>  55
atgagggccc ctgctcagtt ttttgggatc ttgttgctct ggtttccagg tatcagatgt       60

gacatcaaga tgacccagtc tccatcctcc atgtatgcat cgctgggaga gagagtcact      120

attacttgca aggcgagtca ggacattaaa agctatttaa cttggtacca gcagaaacca      180

tggaaatctc ctaagaccct gatcaattat gcaacaagct tggcagatgg ggtcccatca      240

agattcagtg gcagtggatc tggacaagat tattctctaa ccatcagcag cctggagtct      300

gacgatacag caacttatta ctgtctacag catggtcaga gtccgttcac gttcggaggg      360

gggaccaggc tggagataaa acgggctgat gctgcaccaa ctgtatccat cttcccacca      420

tccagtgagc agttaacatc tggaggtgcc tcggtcgtgt gcttcttgaa caacttctac      480

cccaaagaca tcaatgtcaa gtggaagatt gatggcagtg aacgacaaaa tggcgtcctg      540

aacagttgga ctgatcagga cagcaaagac agcacctaca gcatgagcag caccctcacg      600

ttgaccaagg acgagtatga acgacataac agctatacct gtgaggccac tcacaagaca      660

tcaacttcac ccatcgtcaa gagcttcaac aggaatgagt gttag                      705


<210>  56
<211>  214
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  56

Asp Ile Lys Met Thr Gln Ser Pro Ser Ser Met Tyr Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Asp Ile Lys Ser Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Lys Pro Trp Lys Ser Pro Lys Thr Leu Ile 
        35                  40                  45              


Asn Tyr Ala Thr Ser Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Gln Asp Tyr Ser Leu Thr Ile Ser Ser Leu Glu Ser 
65                  70                  75                  80  


Asp Asp Thr Ala Thr Tyr Tyr Cys Leu Gln His Gly Gln Ser Pro Phe 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Arg Leu Glu Ile Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly 
        115                 120                 125             


Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile 
    130                 135                 140                 


Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu 
145                 150                 155                 160 


Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr 
            180                 185                 190         


Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser 
        195                 200                 205             


Phe Asn Arg Asn Glu Cys 
    210                 


<210>  57
<211>  1479
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  57
atgagatcac tgttctcttt acagttactg agcacacagg acctcgccat gggatggagc       60

tgtatcatcc tcttcttggt agcaacagct acaggtgtcc actctcaggt ccaactgcag      120

cagcctgggg ctgagcttgt gaagcctggg gcttcagtga agctgtcctg caaggcttct      180

ggctacacct tcaccagtta ctggatgcag tgggtaaagc agaggcctgg acagggcctt      240

gagtggaccg gagagattga tccttctgat agctatacta actacaatca aaggttcaag      300

ggcaaggcca cattgactgt ggacacatcc tccagcacag cctacacaca gctcagcagc      360

ctgacgtctg aggactctgc ggtccatttc tgtgcaagac gctactatgg taactacgat      420

gggtttgctt actggggcca agggactctg gtcactgtct ctgcagccaa aacaacagcc      480

ccatcggtct atccactggc ccctgtgtgt ggaggtacaa ctggctcctc ggtgactcta      540

ggatgcctgg tcaagggtta tttccctgag ccagtgacct tgacctggaa ctctggatcc      600

ctgtccagtg gtgtgcacac cttcccagct ctcctgcagt ctggcctcta caccctcagc      660

agctcagtga ctgtaacctc gaacacctgg cccagccaga ccatcacctg caatgtggcc      720

cacccggcaa gcagcaccaa agtggacaag aaaattgagc ccagagtgcc cataacacag      780

aacccctgtc ctccactcaa agagtgtccc ccatgcgcag ctccagacct cttgggtgga      840

ccatccgtct tcatcttccc tccaaaggtc aaggatgtac tcatgatctc cctgagcccc      900

atggtcacat gtgtggtggt ggatgtgagc gaggatgacc cagacgtcca gatcagctgg      960

tttgtgaaca acgtggaagt acacacagct cagacacaaa cccatagaga ggattacaac     1020

agtactctcc gggtggtcag tgccctcccc atccagcacc aggactggat gagtggcaag     1080

gagttcaaat gcaaggtcaa caacagagcc ctcccatccc ccatcgagaa aaccatctca     1140

aaacccagag ggccagtaag agctccacag gtatatgtct tgcctccacc agcagaagag     1200

atgactaaga aagagttcag tctgacctgc atgatcacag gcttcttacc tgccgaaatt     1260

gctgtggact ggaccagcaa tgggcgtaca gagcaaaact acaagaacac cgcaacagtc     1320

ctggactctg atggttctta cttcatgtac agcaagctca gagtacaaaa gagcacttgg     1380

gaaagaggaa gtcttttcgc ctgctcagtg gtccacgagg gtctgcacaa tcaccttacg     1440

actaagacca tctcccggtc tctgggtaaa gctagctga                            1479


<210>  58
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  58

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met Gln Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Thr 
        35                  40                  45              


Gly Glu Ile Asp Pro Ser Asp Ser Tyr Thr Asn Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Val Asp Thr Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Thr Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val His Phe Cys 
                85                  90                  95      


Ala Arg Arg Tyr Tyr Gly Asn Tyr Asp Gly Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala Ala Lys Thr Thr Ala Pro Ser Val 
        115                 120                 125             


Tyr Pro Leu Ala Pro Val Cys Gly Gly Thr Thr Gly Ser Ser Val Thr 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu Thr 
145                 150                 155                 160 


Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala Leu 
                165                 170                 175     


Leu Gln Ser Gly Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr Ser 
            180                 185                 190         


Asn Thr Trp Pro Ser Gln Thr Ile Thr Cys Asn Val Ala His Pro Ala 
        195                 200                 205             


Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Val Pro Ile Thr 
    210                 215                 220                 


Gln Asn Pro Cys Pro Pro Leu Lys Glu Cys Pro Pro Cys Ala Ala Pro 
225                 230                 235                 240 


Asp Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Val Lys 
                245                 250                 255     


Asp Val Leu Met Ile Ser Leu Ser Pro Met Val Thr Cys Val Val Val 
            260                 265                 270         


Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn 
        275                 280                 285             


Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr 
    290                 295                 300                 


Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp 
305                 310                 315                 320 


Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Arg Ala Leu 
                325                 330                 335     


Pro Ser Pro Ile Glu Lys Thr Ile Ser Lys Pro Arg Gly Pro Val Arg 
            340                 345                 350         


Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Ala Glu Glu Met Thr Lys 
        355                 360                 365             


Lys Glu Phe Ser Leu Thr Cys Met Ile Thr Gly Phe Leu Pro Ala Glu 
    370                 375                 380                 


Ile Ala Val Asp Trp Thr Ser Asn Gly Arg Thr Glu Gln Asn Tyr Lys 
385                 390                 395                 400 


Asn Thr Ala Thr Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser 
                405                 410                 415     


Lys Leu Arg Val Gln Lys Ser Thr Trp Glu Arg Gly Ser Leu Phe Ala 
            420                 425                 430         


Cys Ser Val Val His Glu Gly Leu His Asn His Leu Thr Thr Lys Thr 
        435                 440                 445             


Ile Ser Arg Ser Leu Gly Lys Ala Ser 
    450                 455         


<210>  59
<211>  2412
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide.

<400>  59
atgacattga acatgctgtt ggggctgagg tgggttttct ttgttgtttt ttatcaaggt       60

gtgcattgtg aggtgcagct tgttgagtct ggtggaggat tggtgcagcc taaagggtca      120

ttgaaactct catgtgcagc ctctggatta accttcaata tctacgccat gaactgggtc      180

cgccaggctc caggaaaggg tttggaatgg gttgctcgca taagaaataa aagtaataat      240

tatgcaacat attatgccga ttcagtgaaa gacaggttca ccatctccag agatgattca      300

caaagcttgc tctatctgca aatgaacaac ttgaaaactg aggacacagc catgtattac      360

tgtgtgggac gggactggtt tgattactgg ggccaaggga ctctggtcac tgtctctgca      420

gccaaaacga agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag      480

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      540

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      660

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      720

aaatatggtc ccccatgccc accctgccca gcacctgagt tcgaaggggg accatcagtc      780

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      840

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa     1080

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg     1320

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc     1380

ctctccctgt ctctgggtaa agctagcgat acaacagaac ctgcaacacc tacaacacct     1440

gtaacaacag acacaatatg tataggctac catgcgaaca attcaaccga cactgttgac     1500

acagtactcg agaagaatgt gacagtgaca cactctgtta acctgctcga agacagccac     1560

aacggaaaac tatgtagatt aaaaggaata gccccactac aattggggaa atgtaacatc     1620

gccggatggc tcttgggaaa cccagaatgc gacccactgc ttccagtgag atcatggtcc     1680

tacattgtag aaacaccaaa ctctgagaat ggaatatgtt atccaggaga tttcatcgac     1740

tatgaggagc tgagggagca attgagctca gtgtcatcat tcgaaagatt cgaaatattt     1800

cccaaagaaa gctcatggcc caaccacaac acaaacggag taacggcagc atgctcccat     1860

gaggggaaaa gcagttttta cagaaatttg ctatggctga cggagaagga gggctcatac     1920

ccaaagctga aaaattctta tgtgaacaaa aaagggaaag aagtccttgt actgtggggt     1980

attcatcacc cgcctaacag taaggaacaa cagaatctct atcagaatga aaatgcttat     2040

gtctctgtag tgacttcaaa ttataacagg agatttaccc cggaaatagc agaaagaccc     2100

aaagtaagag atcaagctgg gaggatgaac tattactgga ccttgctaaa acccggagac     2160

acaataatat ttgaggcaaa tggaaatcta atagcaccaa tgtatgcttt cgcactgagt     2220

agaggctttg ggtccggcat catcacctca aacgcatcaa tgcatgagtg taacacgaag     2280

tgtcaaacac ccctgggagc tataaacagc agtctccctt accagaatat acacccagtc     2340

acaataggag agtgcccaaa atacgtcagg agtgccaaat tgaggatggt tcaccatcac     2400

catcaccatt ga                                                         2412


<210>  60
<211>  780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  60

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Asn Ile Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Asn Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Leu 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Gly Arg Asp Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Lys Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Ser Asp Thr 
        435                 440                 445             


Thr Glu Pro Ala Thr Pro Thr Thr Pro Val Thr Thr Asp Thr Ile Cys 
    450                 455                 460                 


Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr Val Asp Thr Val Leu 
465                 470                 475                 480 


Glu Lys Asn Val Thr Val Thr His Ser Val Asn Leu Leu Glu Asp Ser 
                485                 490                 495     


His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile Ala Pro Leu Gln Leu 
            500                 505                 510         


Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly Asn Pro Glu Cys Asp 
        515                 520                 525             


Pro Leu Leu Pro Val Arg Ser Trp Ser Tyr Ile Val Glu Thr Pro Asn 
    530                 535                 540                 


Ser Glu Asn Gly Ile Cys Tyr Pro Gly Asp Phe Ile Asp Tyr Glu Glu 
545                 550                 555                 560 


Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe Glu Arg Phe Glu Ile 
                565                 570                 575     


Phe Pro Lys Glu Ser Ser Trp Pro Asn His Asn Thr Asn Gly Val Thr 
            580                 585                 590         


Ala Ala Cys Ser His Glu Gly Lys Ser Ser Phe Tyr Arg Asn Leu Leu 
        595                 600                 605             


Trp Leu Thr Glu Lys Glu Gly Ser Tyr Pro Lys Leu Lys Asn Ser Tyr 
    610                 615                 620                 


Val Asn Lys Lys Gly Lys Glu Val Leu Val Leu Trp Gly Ile His His 
625                 630                 635                 640 


Pro Pro Asn Ser Lys Glu Gln Gln Asn Leu Tyr Gln Asn Glu Asn Ala 
                645                 650                 655     


Tyr Val Ser Val Val Thr Ser Asn Tyr Asn Arg Arg Phe Thr Pro Glu 
            660                 665                 670         


Ile Ala Glu Arg Pro Lys Val Arg Asp Gln Ala Gly Arg Met Asn Tyr 
        675                 680                 685             


Tyr Trp Thr Leu Leu Lys Pro Gly Asp Thr Ile Ile Phe Glu Ala Asn 
    690                 695                 700                 


Gly Asn Leu Ile Ala Pro Met Tyr Ala Phe Ala Leu Ser Arg Gly Phe 
705                 710                 715                 720 


Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser Met His Glu Cys Asn Thr 
                725                 730                 735     


Lys Cys Gln Thr Pro Leu Gly Ala Ile Asn Ser Ser Leu Pro Tyr Gln 
            740                 745                 750         


Asn Ile His Pro Val Thr Ile Gly Glu Cys Pro Lys Tyr Val Arg Ser 
        755                 760                 765             


Ala Lys Leu Arg Met Val His His His His His His 
    770                 775                 780 


<210>  61
<211>  2412
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Syntehtic oligonucleotide.

<400>  61
atgacattga acatgctgtt ggggctgagg tgggttttct ttgttgtttt ttatcaaggt       60

gtgcattgtg aggtgcagct tgttgagtct ggtggaggat tggtgcagcc taaagggtca      120

ttgaaactct catgtgcagc ctctggatta accttcaata tctacgccat gaactgggtc      180

cgccaggctc caggaaaggg tttggaatgg gttgctcgca taagaaataa aagtaataat      240

tatgcaacat attatgccga ttcagtgaaa gacaggttca ccatctccag agatgattca      300

caaagcttgc tctatctgca aatgaacaac ttgaaaactg aggacacagc catgtattac      360

tgtgtgggac gggactggtt tgattactgg ggccaaggga ctctggtcac tgtctctgca      420

gccaaaacga agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag      480

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      540

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      660

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      720

aaatatggtc ccccatgccc accctgccca gcacctgagt tcgaaggggg accatcagtc      780

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      840

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa     1080

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg     1320

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc     1380

ctctccctgt ctctgggtaa agctagcgat acaacagaac ctgcaacacc tacaacacct     1440

gtaacaacag atcagatttg cattggttac catgcaaaca actcgacaga gcaggttgac     1500

acaataatgg aaaagaacgt tactgttaca catgcccaag acatactgga aaagaaacac     1560

aacgggaagc tctgcgatct agatggagtg aagcctctaa ttttgagaga ttgtagcgta     1620

gctggatggc tcctcggaaa cccaatgtgt gacgaattca tcaatgtgcc ggaatggtct     1680

tacatagtgg agaaggccaa tccagtcaat gacctctgtt acccagggga tttcaatgac     1740

tatgaagaat tgaaacacct attgagcaga ataaaccatt ttgagaaaat tcagatcatc     1800

cccaaaagtt cttggtccag tcatgaagcc tcattagggg tgagctcagc atgtccatac     1860

cagggaaagt cctccttttt cagaaatgtg gtatggctta tcaaaaagaa cagtacatac     1920

ccaacaataa agaggagcta caataatacc aaccaagaag atcttttggt actgtggggg     1980

attcaccatc ctaatgatgc ggcagagcag acaaagctct atcaaaaccc aaccacctat     2040

atttccgttg ggacatcaac actaaaccag agattggtac caagaatagc tactagatcc     2100

aaagtaaacg ggcaaagtgg aaggatggag ttcttctgga caattttaaa gccgaatgat     2160

gcaatcaact tcgagagtaa tggaaatttc attgctccag aatatgcata caaaattgtc     2220

aagaaagggg actcaacaat tatgaaaagt gaattggaat atggtaactg caacaccaag     2280

tgtcaaactc caatgggggc gataaactct agcatgccat tccacaatat acaccctctc     2340

accattgggg aatgccccaa atatgtgaaa tcaaacagat tagtccttgc gcaccatcac     2400

catcaccatt ga                                                         2412


<210>  62
<211>  780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Syntehtic peptide.

<400>  62

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Asn Ile Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Asn Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Leu 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Gly Arg Asp Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Lys Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Ser Asp Thr 
        435                 440                 445             


Thr Glu Pro Ala Thr Pro Thr Thr Pro Val Thr Thr Asp Gln Ile Cys 
    450                 455                 460                 


Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val Asp Thr Ile Met 
465                 470                 475                 480 


Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile Leu Glu Lys Lys 
                485                 490                 495     


His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys Pro Leu Ile Leu 
            500                 505                 510         


Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn Pro Met Cys Asp 
        515                 520                 525             


Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val Glu Lys Ala Asn 
    530                 535                 540                 


Pro Val Asn Asp Leu Cys Tyr Pro Gly Asp Phe Asn Asp Tyr Glu Glu 
545                 550                 555                 560 


Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu Lys Ile Gln Ile 
                565                 570                 575     


Ile Pro Lys Ser Ser Trp Ser Ser His Glu Ala Ser Leu Gly Val Ser 
            580                 585                 590         


Ser Ala Cys Pro Tyr Gln Gly Lys Ser Ser Phe Phe Arg Asn Val Val 
        595                 600                 605             


Trp Leu Ile Lys Lys Asn Ser Thr Tyr Pro Thr Ile Lys Arg Ser Tyr 
    610                 615                 620                 


Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp Gly Ile His His 
625                 630                 635                 640 


Pro Asn Asp Ala Ala Glu Gln Thr Lys Leu Tyr Gln Asn Pro Thr Thr 
                645                 650                 655     


Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg Leu Val Pro Arg 
            660                 665                 670         


Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly Arg Met Glu Phe 
        675                 680                 685             


Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn Phe Glu Ser Asn 
    690                 695                 700                 


Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile Val Lys Lys Gly 
705                 710                 715                 720 


Asp Ser Thr Ile Met Lys Ser Glu Leu Glu Tyr Gly Asn Cys Asn Thr 
                725                 730                 735     


Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser Met Pro Phe His 
            740                 745                 750         


Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys Tyr Val Lys Ser 
        755                 760                 765             


Asn Arg Leu Val Leu Ala His His His His His His 
    770                 775                 780 


<210>  63
<211>  2202
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide.

<400>  63
atgacattga acatgctgtt ggggctgaag tgggttttct ttgttgtttt ttatcaaggt       60

gtgcattgtg aggtgcagct tgttgagtct ggtggaggat tggtgcagcc taaagggtca      120

ttgaaactct catgtgcagc ctctggatta accttcaata tctacgccat gaactgggtc      180

cgccaggctc caggaaaggg tttggaatgg gttgctcgca taagaaataa aagtaataat      240

tatgcaacat attatgccga ttcagtgaaa gacaggttca ccatctccag agatgattca      300

caaagcttgc tctatctgca aatgaacaac ttgaaaactg aggacacagc catgtattac      360

tgtgtgggac gggactggtt tgattactgg ggccaaggga ctctggtcac tgtctctgca      420

gccaaaacga agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag      480

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      540

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      660

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      720

aaatatggtc ccccatgccc accctgccca gcacctgagt tcgaaggggg accatcagtc      780

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      840

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa     1080

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg     1320

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc     1380

ctctccctgt ctctgggtaa agctagcgat acaacagaac ctgcaacacc tacaacacct     1440

gtaacaacac cgacaacaac acttctagcg cccctcatcc tgtctcggat tgtgggaggc     1500

tgggagtgcg agaagcattc ccaaccctgg caggtgcttg tggcctctcg tggcagggca     1560

gtctgcggcg gtgttctggt gcacccccag tgggtcctca cagctgccca ctgcatcagg     1620

aacaaaagcg tgatcttgct gggtcggcac agcctgtttc atcctgaaga cacaggccag     1680

gtatttcagg tcagccacag cttcccacac ccgctctacg atatgagcct cctgaagaat     1740

cgattcctca ggccaggtga tgactccagc cacgacctca tgctgctccg cctgtcagag     1800

cctgccgagc tcacggatgc tgtgaaggtc atggacctgc ccacccagga gccagcactg     1860

gggaccacct gctacgcctc aggctggggc agcattgaac cagaggagtt cttgacccca     1920

aagaaacttc agtgtgtgga cctccatgtt atttccaatg acgtgtgtgc gcaagttcac     1980

cctcagaagg tgaccaagtt catgctgtgt gctggacgct ggacaggggg caaaagcacc     2040

tgctcgggtg attctggggg cccacttgtc tgtaatggtg tgcttcaagg tatcacgtca     2100

tggggcagtg aaccatgtgc cctgcccgaa aggccttccc tgtacaccaa ggtggtgcat     2160

taccggaagt ggatcaagga caccatcgtg gccaacccct ga                        2202


<210>  64
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  64

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Lys Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Leu Thr Phe Asn Ile Tyr 
            20                  25                  30          


Ala Met Asn Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Arg Ile Arg Asn Lys Ser Asn Asn Tyr Ala Thr Tyr Tyr Ala Asp 
    50                  55                  60                  


Ser Val Lys Asp Arg Phe Thr Ile Ser Arg Asp Asp Ser Gln Ser Leu 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Asn Leu Lys Thr Glu Asp Thr Ala Met Tyr 
                85                  90                  95      


Tyr Cys Val Gly Arg Asp Trp Phe Asp Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Lys Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Ser Asp Thr 
        435                 440                 445             


Thr Glu Pro Ala Thr Pro Thr Thr Pro Val Thr Thr Pro Thr Thr Thr 
    450                 455                 460                 


Leu Leu Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys 
465                 470                 475                 480 


Glu Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg 
                485                 490                 495     


Ala Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala 
            500                 505                 510         


Ala His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser 
        515                 520                 525             


Leu Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser 
    530                 535                 540                 


Phe Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu 
545                 550                 555                 560 


Arg Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser 
                565                 570                 575     


Glu Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr 
            580                 585                 590         


Gln Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser 
        595                 600                 605             


Ile Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp 
    610                 615                 620                 


Leu His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys 
625                 630                 635                 640 


Val Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser 
                645                 650                 655     


Thr Cys Ser Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Gly Val Leu 
            660                 665                 670         


Gln Gly Ile Thr Ser Trp Gly Ser Glu Pro Cys Ala Leu Pro Glu Arg 
        675                 680                 685             


Pro Ser Leu Tyr Thr Lys Val Val His Tyr Arg Lys Trp Ile Lys Asp 
    690                 695                 700                 


Thr Ile Val Ala Asn Pro 
705                 710 


<210>  65
<211>  2415
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Syntehtic oligonucleotide.

<400>  65
atggacccca aaggctccct ttcctggaga atacttctgt ttctctccct ggcttttgag       60

ttgtcgtacg gacaggttca gctgcggcag tctggacctg agctggtgaa gcctggggct      120

tcagtgaaga tgtcctgcaa ggcttctgga tacacattta ctgactatgt tataagttgg      180

gtgaagcaga gaactggaca gggccttgag tggattggag atatttatcc tggaagtggt      240

tattctttct acaatgagaa cttcaagggc aaggccacac tgactgcaga caaatcctcc      300

accacagcct acatgcagct cagcagcctg acatctgagg actctgcggt ctatttctgt      360

gcaacctact ataactaccc ttttgcttac tggggccaag ggactctggt cactgtctct      420

gcagccaaaa caacgggccc atccgtcttc cccctggcgc cctgctccag gagcacctcc      480

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacgaag      660

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gagagttgag      720

tccaaatatg gtcccccatg cccaccctgc ccagcacctg agttcgaagg gggaccatca      780

gtcttcctgt tccccccaaa acccaaggac actctcatga tctcccggac ccctgaggtc      840

acgtgcgtgg tggtggacgt gagccaggaa gaccccgagg tccagttcaa ctggtacgtg      900

gatggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagtt caacagcacg      960

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaacgg caaggagtac     1020

aagtgcaagg tctccaacaa aggcctcccg tcctccatcg agaaaaccat ctccaaagcc     1080

aaagggcagc cccgagagcc acaggtgtac accctgcccc catcccagga ggagatgacc     1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg     1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1260

tccgacggct ccttcttcct ctacagcagg ctaaccgtgg acaagagcag gtggcaggag     1320

gggaatgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacacagaag     1380

agcctctccc tgtctctggg taaagctagc gatacaacag aacctgcaac acctacaaca     1440

cctgtaacaa cagatcagat ttgcattggt taccatgcaa acaactcgac agagcaggtt     1500

gacacaataa tggaaaagaa cgttactgtt acacatgccc aagacatact ggaaaagaaa     1560

cacaacggga agctctgcga tctagatgga gtgaagcctc taattttgag agattgtagc     1620

gtagctggat ggctcctcgg aaacccaatg tgtgacgaat tcatcaatgt gccggaatgg     1680

tcttacatag tggagaaggc caatccagtc aatgacctct gttacccagg ggatttcaat     1740

gactatgaag aattgaaaca cctattgagc agaataaacc attttgagaa aattcagatc     1800

atccccaaaa gttcttggtc cagtcatgaa gcctcattag gggtgagctc agcatgtcca     1860

taccagggaa agtcctcctt tttcagaaat gtggtatggc ttatcaaaaa gaacagtaca     1920

tacccaacaa taaagaggag ctacaataat accaaccaag aagatctttt ggtactgtgg     1980

gggattcacc atcctaatga tgcggcagag cagacaaagc tctatcaaaa cccaaccacc     2040

tatatttccg ttgggacatc aacactaaac cagagattgg taccaagaat agctactaga     2100

tccaaagtaa acgggcaaag tggaaggatg gagttcttct ggacaatttt aaagccgaat     2160

gatgcaatca acttcgagag taatggaaat ttcattgctc cagaatatgc atacaaaatt     2220

gtcaagaaag gggactcaac aattatgaaa agtgaattgg aatatggtaa ctgcaacacc     2280

aagtgtcaaa ctccaatggg ggcgataaac tctagcatgc cattccacaa tatacaccct     2340

ctcaccattg gggaatgccc caaatatgtg aaatcaaaca gattagtcct tgcgcaccat     2400

caccatcacc attga                                                      2415


<210>  66
<211>  780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  66

Gln Val Gln Leu Arg Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Ser Gly Tyr Ser Phe Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Tyr Tyr Asn Tyr Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Lys Thr Thr Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Ser Asp Thr 
        435                 440                 445             


Thr Glu Pro Ala Thr Pro Thr Thr Pro Val Thr Thr Asp Gln Ile Cys 
    450                 455                 460                 


Ile Gly Tyr His Ala Asn Asn Ser Thr Glu Gln Val Asp Thr Ile Met 
465                 470                 475                 480 


Glu Lys Asn Val Thr Val Thr His Ala Gln Asp Ile Leu Glu Lys Lys 
                485                 490                 495     


His Asn Gly Lys Leu Cys Asp Leu Asp Gly Val Lys Pro Leu Ile Leu 
            500                 505                 510         


Arg Asp Cys Ser Val Ala Gly Trp Leu Leu Gly Asn Pro Met Cys Asp 
        515                 520                 525             


Glu Phe Ile Asn Val Pro Glu Trp Ser Tyr Ile Val Glu Lys Ala Asn 
    530                 535                 540                 


Pro Val Asn Asp Leu Cys Tyr Pro Gly Asp Phe Asn Asp Tyr Glu Glu 
545                 550                 555                 560 


Leu Lys His Leu Leu Ser Arg Ile Asn His Phe Glu Lys Ile Gln Ile 
                565                 570                 575     


Ile Pro Lys Ser Ser Trp Ser Ser His Glu Ala Ser Leu Gly Val Ser 
            580                 585                 590         


Ser Ala Cys Pro Tyr Gln Gly Lys Ser Ser Phe Phe Arg Asn Val Val 
        595                 600                 605             


Trp Leu Ile Lys Lys Asn Ser Thr Tyr Pro Thr Ile Lys Arg Ser Tyr 
    610                 615                 620                 


Asn Asn Thr Asn Gln Glu Asp Leu Leu Val Leu Trp Gly Ile His His 
625                 630                 635                 640 


Pro Asn Asp Ala Ala Glu Gln Thr Lys Leu Tyr Gln Asn Pro Thr Thr 
                645                 650                 655     


Tyr Ile Ser Val Gly Thr Ser Thr Leu Asn Gln Arg Leu Val Pro Arg 
            660                 665                 670         


Ile Ala Thr Arg Ser Lys Val Asn Gly Gln Ser Gly Arg Met Glu Phe 
        675                 680                 685             


Phe Trp Thr Ile Leu Lys Pro Asn Asp Ala Ile Asn Phe Glu Ser Asn 
    690                 695                 700                 


Gly Asn Phe Ile Ala Pro Glu Tyr Ala Tyr Lys Ile Val Lys Lys Gly 
705                 710                 715                 720 


Asp Ser Thr Ile Met Lys Ser Glu Leu Glu Tyr Gly Asn Cys Asn Thr 
                725                 730                 735     


Lys Cys Gln Thr Pro Met Gly Ala Ile Asn Ser Ser Met Pro Phe His 
            740                 745                 750         


Asn Ile His Pro Leu Thr Ile Gly Glu Cys Pro Lys Tyr Val Lys Ser 
        755                 760                 765             


Asn Arg Leu Val Leu Ala His His His His His His 
    770                 775                 780 


<210>  67
<211>  1638
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Syntehtic oligonucleotide.

<400>  67
atggacccca aaggctccct ttcctggaga atacttctgt ttctctccct ggcttttgag       60

ttgtcgtacg gacaggttca gctgcggcag tctggacctg agctggtgaa gcctggggct      120

tcagtgaaga tgtcctgcaa ggcttctgga tacacattta ctgactatgt tataagttgg      180

gtgaagcaga gaactggaca gggccttgag tggattggag atatttatcc tggaagtggt      240

tattctttct acaatgagaa cttcaagggc aaggccacac tgactgcaga caaatcctcc      300

accacagcct acatgcagct cagcagcctg acatctgagg actctgcggt ctatttctgt      360

gcaacctact ataactaccc ttttgcttac tggggccaag ggactctggt cactgtctct      420

gcagccaaaa caacgggccc atccgtcttc cccctggcgc cctgctccag gagcacctcc      480

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacgaag      660

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gagagttgag      720

tccaaatatg gtcccccatg cccaccctgc ccagcacctg agttcgaagg gggaccatca      780

gtcttcctgt tccccccaaa acccaaggac actctcatga tctcccggac ccctgaggtc      840

acgtgcgtgg tggtggacgt gagccaggaa gaccccgagg tccagttcaa ctggtacgtg      900

gatggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagtt caacagcacg      960

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaacgg caaggagtac     1020

aagtgcaagg tctccaacaa aggcctcccg tcctccatcg agaaaaccat ctccaaagcc     1080

aaagggcagc cccgagagcc acaggtgtac accctgcccc catcccagga ggagatgacc     1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg     1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1260

tccgacggct ccttcttcct ctacagcagg ctaaccgtgg acaagagcag gtggcaggag     1320

gggaatgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacacagaag     1380

agcctctccc tgtctctggg taaagctagc aattctcctc aaaatgaagt actgtacgga     1440

gatgtgaatg atgacggaaa agtaaactcc actgacttga ctttgttaaa aagatatgtt     1500

cttaaagccg tctcaactct cccttcttcc aaagctgaaa agaacgcaga tgtaaatcgt     1560

gacggaagag ttaattccag tgatgtcaca atactttcaa gatatttgat aagggtaatc     1620

gagaaattac caatataa                                                   1638


<210>  68
<211>  521
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  68

Gln Val Gln Leu Arg Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Ser Gly Tyr Ser Phe Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Tyr Tyr Asn Tyr Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Lys Thr Thr Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Ser Asn Ser 
        435                 440                 445             


Pro Gln Asn Glu Val Leu Tyr Gly Asp Val Asn Asp Asp Gly Lys Val 
    450                 455                 460                 


Asn Ser Thr Asp Leu Thr Leu Leu Lys Arg Tyr Val Leu Lys Ala Val 
465                 470                 475                 480 


Ser Thr Leu Pro Ser Ser Lys Ala Glu Lys Asn Ala Asp Val Asn Arg 
                485                 490                 495     


Asp Gly Arg Val Asn Ser Ser Asp Val Thr Ile Leu Ser Arg Tyr Leu 
            500                 505                 510         


Ile Arg Val Ile Glu Lys Leu Pro Ile 
        515                 520     


<210>  69
<211>  2415
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Syntehtic oligonucleotide.

<400>  69
atggacccca aaggctccct ttcctggaga atacttctgt ttctctccct ggcttttgag       60

ttgtcgtacg gacaggttca gctgcggcag tctggacctg agctggtgaa gcctggggct      120

tcagtgaaga tgtcctgcaa ggcttctgga tacacattta ctgactatgt tataagttgg      180

gtgaagcaga gaactggaca gggccttgag tggattggag atatttatcc tggaagtggt      240

tattctttct acaatgagaa cttcaagggc aaggccacac tgactgcaga caaatcctcc      300

accacagcct acatgcagct cagcagcctg acatctgagg actctgcggt ctatttctgt      360

gcaacctact ataactaccc ttttgcttac tggggccaag ggactctggt cactgtctct      420

gcagccaaaa caacgggccc atccgtcttc cccctggcgc cctgctccag gagcacctcc      480

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacgaag      660

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gagagttgag      720

tccaaatatg gtcccccatg cccaccctgc ccagcacctg agttcgaagg gggaccatca      780

gtcttcctgt tccccccaaa acccaaggac actctcatga tctcccggac ccctgaggtc      840

acgtgcgtgg tggtggacgt gagccaggaa gaccccgagg tccagttcaa ctggtacgtg      900

gatggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagtt caacagcacg      960

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaacgg caaggagtac     1020

aagtgcaagg tctccaacaa aggcctcccg tcctccatcg agaaaaccat ctccaaagcc     1080

aaagggcagc cccgagagcc acaggtgtac accctgcccc catcccagga ggagatgacc     1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg     1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1260

tccgacggct ccttcttcct ctacagcagg ctaaccgtgg acaagagcag gtggcaggag     1320

gggaatgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacacagaag     1380

agcctctccc tgtctctggg taaagctagc gatacaacag aacctgcaac acctacaaca     1440

cctgtaacaa cagacacaat atgtataggc taccatgcga acaattcaac cgacactgtt     1500

gacacagtac tcgagaagaa tgtgacagtg acacactctg ttaacctgct cgaagacagc     1560

cacaacggaa aactatgtag attaaaagga atagccccac tacaattggg gaaatgtaac     1620

atcgccggat ggctcttggg aaacccagaa tgcgacccac tgcttccagt gagatcatgg     1680

tcctacattg tagaaacacc aaactctgag aatggaatat gttatccagg agatttcatc     1740

gactatgagg agctgaggga gcaattgagc tcagtgtcat cattcgaaag attcgaaata     1800

tttcccaaag aaagctcatg gcccaaccac aacacaaacg gagtaacggc agcatgctcc     1860

catgagggga aaagcagttt ttacagaaat ttgctatggc tgacggagaa ggagggctca     1920

tacccaaagc tgaaaaattc ttatgtgaac aaaaaaggga aagaagtcct tgtactgtgg     1980

ggtattcatc acccgcctaa cagtaaggaa caacagaatc tctatcagaa tgaaaatgct     2040

tatgtctctg tagtgacttc aaattataac aggagattta ccccggaaat agcagaaaga     2100

cccaaagtaa gagatcaagc tgggaggatg aactattact ggaccttgct aaaacccgga     2160

gacacaataa tatttgaggc aaatggaaat ctaatagcac caatgtatgc tttcgcactg     2220

agtagaggct ttgggtccgg catcatcacc tcaaacgcat caatgcatga gtgtaacacg     2280

aagtgtcaaa cacccctggg agctataaac agcagtctcc cttaccagaa tatacaccca     2340

gtcacaatag gagagtgccc aaaatacgtc aggagtgcca aattgaggat ggttcaccat     2400

caccatcacc attga                                                      2415


<210>  70
<211>  780
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  70

Gln Val Gln Leu Arg Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Ser Gly Tyr Ser Phe Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Tyr Tyr Asn Tyr Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Lys Thr Thr Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Ser Asp Thr 
        435                 440                 445             


Thr Glu Pro Ala Thr Pro Thr Thr Pro Val Thr Thr Asp Thr Ile Cys 
    450                 455                 460                 


Ile Gly Tyr His Ala Asn Asn Ser Thr Asp Thr Val Asp Thr Val Leu 
465                 470                 475                 480 


Glu Lys Asn Val Thr Val Thr His Ser Val Asn Leu Leu Glu Asp Ser 
                485                 490                 495     


His Asn Gly Lys Leu Cys Arg Leu Lys Gly Ile Ala Pro Leu Gln Leu 
            500                 505                 510         


Gly Lys Cys Asn Ile Ala Gly Trp Leu Leu Gly Asn Pro Glu Cys Asp 
        515                 520                 525             


Pro Leu Leu Pro Val Arg Ser Trp Ser Tyr Ile Val Glu Thr Pro Asn 
    530                 535                 540                 


Ser Glu Asn Gly Ile Cys Tyr Pro Gly Asp Phe Ile Asp Tyr Glu Glu 
545                 550                 555                 560 


Leu Arg Glu Gln Leu Ser Ser Val Ser Ser Phe Glu Arg Phe Glu Ile 
                565                 570                 575     


Phe Pro Lys Glu Ser Ser Trp Pro Asn His Asn Thr Asn Gly Val Thr 
            580                 585                 590         


Ala Ala Cys Ser His Glu Gly Lys Ser Ser Phe Tyr Arg Asn Leu Leu 
        595                 600                 605             


Trp Leu Thr Glu Lys Glu Gly Ser Tyr Pro Lys Leu Lys Asn Ser Tyr 
    610                 615                 620                 


Val Asn Lys Lys Gly Lys Glu Val Leu Val Leu Trp Gly Ile His His 
625                 630                 635                 640 


Pro Pro Asn Ser Lys Glu Gln Gln Asn Leu Tyr Gln Asn Glu Asn Ala 
                645                 650                 655     


Tyr Val Ser Val Val Thr Ser Asn Tyr Asn Arg Arg Phe Thr Pro Glu 
            660                 665                 670         


Ile Ala Glu Arg Pro Lys Val Arg Asp Gln Ala Gly Arg Met Asn Tyr 
        675                 680                 685             


Tyr Trp Thr Leu Leu Lys Pro Gly Asp Thr Ile Ile Phe Glu Ala Asn 
    690                 695                 700                 


Gly Asn Leu Ile Ala Pro Met Tyr Ala Phe Ala Leu Ser Arg Gly Phe 
705                 710                 715                 720 


Gly Ser Gly Ile Ile Thr Ser Asn Ala Ser Met His Glu Cys Asn Thr 
                725                 730                 735     


Lys Cys Gln Thr Pro Leu Gly Ala Ile Asn Ser Ser Leu Pro Tyr Gln 
            740                 745                 750         


Asn Ile His Pro Val Thr Ile Gly Glu Cys Pro Lys Tyr Val Arg Ser 
        755                 760                 765             


Ala Lys Leu Arg Met Val His His His His His His 
    770                 775                 780 


<210>  71
<211>  2154
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Syntehtic oligonucleotide.

<400>  71
atggacccca aaggctccct ttcctggaga atacttctgt ttctctccct ggcttttgag       60

ttgtcgtacg gacaggttca gctgcggcag tctggacctg agctggtgaa gcctggggct      120

tcagtgaaga tgtcctgcaa ggcttctgga tacacattta ctgactatgt tataagttgg      180

gtgaagcaga gaactggaca gggccttgag tggattggag atatttatcc tggaagtggt      240

tattctttct acaatgagaa cttcaagggc aaggccacac tgactgcaga caaatcctcc      300

accacagcct acatgcagct cagcagcctg acatctgagg actctgcggt ctatttctgt      360

gcaacctact ataactaccc ttttgcttac tggggccaag ggactctggt cactgtctct      420

gcagccaaaa caacgggccc atccgtcttc cccctggcgc cctgctccag gagcacctcc      480

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacgaag      660

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gagagttgag      720

tccaaatatg gtcccccatg cccaccctgc ccagcacctg agttcgaagg gggaccatca      780

gtcttcctgt tccccccaaa acccaaggac actctcatga tctcccggac ccctgaggtc      840

acgtgcgtgg tggtggacgt gagccaggaa gaccccgagg tccagttcaa ctggtacgtg      900

gatggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagtt caacagcacg      960

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaacgg caaggagtac     1020

aagtgcaagg tctccaacaa aggcctcccg tcctccatcg agaaaaccat ctccaaagcc     1080

aaagggcagc cccgagagcc acaggtgtac accctgcccc catcccagga ggagatgacc     1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg     1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1260

tccgacggct ccttcttcct ctacagcagg ctaaccgtgg acaagagcag gtggcaggag     1320

gggaatgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacacagaag     1380

agcctctccc tgtctctggg taaagctagc gacatggcca agaaggagac agtctggagg     1440

ctcgaggagt tcggtaggcc tatagtgcag aacatccagg ggcaaatggt acatcaggcc     1500

atatcaccta gaactttaaa tgcatgggta aaagtagtag aagagaaggc tttcagccca     1560

gaagtaatac ccatgttttc agcattatca gaaggagcca ccccacaaga tttaaacacc     1620

atgctaaaca cagtgggggg acatcaagca gccatgcaaa tgttaaaaga gaccatcaat     1680

gaggaagctg cagaatggga tagagtacat ccagtgcatg cagggcctat tgcaccaggc     1740

cagatgagag aaccaagggg aagtgacata gcaggaacta ctagtaccct tcaggaacaa     1800

ataggatgga tgacaaataa tccacctatc ccagtaggag aaatttataa aagatggata     1860

atcctgggat taaataaaat agtaagaatg tatagcccta ccagcattct ggacataaga     1920

caaggaccaa aagaaccttt tagagactat gtagaccggt tctataaaac tctaagagcc     1980

gagcaagctt cacaggaggt aaaaaattgg atgacagaaa ccttgttggt ccaaaatgcg     2040

aacccagatt gtaagactat tttaaaagca ttgggaccag cggctacact agaagaaatg     2100

atgacagcat gtcagggagt aggaggaccc ggccataagg caagagtttt gtga           2154


<210>  72
<211>  693
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  72

Gln Val Gln Leu Arg Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Ser Gly Tyr Ser Phe Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Tyr Tyr Asn Tyr Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Lys Thr Thr Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Ser Asp Met 
        435                 440                 445             


Ala Lys Lys Glu Thr Val Trp Arg Leu Glu Glu Phe Gly Arg Pro Ile 
    450                 455                 460                 


Val Gln Asn Ile Gln Gly Gln Met Val His Gln Ala Ile Ser Pro Arg 
465                 470                 475                 480 


Thr Leu Asn Ala Trp Val Lys Val Val Glu Glu Lys Ala Phe Ser Pro 
                485                 490                 495     


Glu Val Ile Pro Met Phe Ser Ala Leu Ser Glu Gly Ala Thr Pro Gln 
            500                 505                 510         


Asp Leu Asn Thr Met Leu Asn Thr Val Gly Gly His Gln Ala Ala Met 
        515                 520                 525             


Gln Met Leu Lys Glu Thr Ile Asn Glu Glu Ala Ala Glu Trp Asp Arg 
    530                 535                 540                 


Val His Pro Val His Ala Gly Pro Ile Ala Pro Gly Gln Met Arg Glu 
545                 550                 555                 560 


Pro Arg Gly Ser Asp Ile Ala Gly Thr Thr Ser Thr Leu Gln Glu Gln 
                565                 570                 575     


Ile Gly Trp Met Thr Asn Asn Pro Pro Ile Pro Val Gly Glu Ile Tyr 
            580                 585                 590         


Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys Ile Val Arg Met Tyr Ser 
        595                 600                 605             


Pro Thr Ser Ile Leu Asp Ile Arg Gln Gly Pro Lys Glu Pro Phe Arg 
    610                 615                 620                 


Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu Arg Ala Glu Gln Ala Ser 
625                 630                 635                 640 


Gln Glu Val Lys Asn Trp Met Thr Glu Thr Leu Leu Val Gln Asn Ala 
                645                 650                 655     


Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala Leu Gly Pro Ala Ala Thr 
            660                 665                 670         


Leu Glu Glu Met Met Thr Ala Cys Gln Gly Val Gly Gly Pro Gly His 
        675                 680                 685             


Lys Ala Arg Val Leu 
    690             


<210>  73
<211>  2187
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Syntehtic oligonucleotide.

<400>  73
atggaatgga ggatctttct cttcatcctg tcaggaactg caggtgtcca ctcccaggtt       60

cagctgcggc agtctggacc tgagctggtg aagcctgggg cttcagtgaa gatgtcctgc      120

aaggcttctg gatacacatt tactgactat gttataagtt gggtgaagca gagaactgga      180

cagggccttg agtggattgg agatatttat cctggaagtg gttattcttt ctacaatgag      240

aacttcaagg gcaaggccac actgactgca gacaaatcct ccaccacagc ctacatgcag      300

ctcagcagcc tgacatctga ggactctgcg gtctatttct gtgcaaccta ctataactac      360

ccttttgctt actggggcca agggactctg gtcactgtct ctgcagccaa aacaacgggc      420

ccatccgtct tccccctggc gccctgctcc aggagcacct ccgagagcac agccgccctg      480

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      540

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      600

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcacga agacctacac ctgcaacgta      660

gatcacaagc ccagcaacac caaggtggac aagagagttg agtccaaata tggtccccca      720

tgcccaccct gcccagcacc tgagttcgaa gggggaccat cagtcttcct gttcccccca      780

aaacccaagg acactctcat gatctcccgg acccctgagg tcacgtgcgt ggtggtggac      840

gtgagccagg aagaccccga ggtccagttc aactggtacg tggatggcgt ggaggtgcat      900

aatgccaaga caaagccgcg ggaggagcag ttcaacagca cgtaccgtgt ggtcagcgtc      960

ctcaccgtcc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtctccaac     1020

aaaggcctcc cgtcctccat cgagaaaacc atctccaaag ccaaagggca gccccgagag     1080

ccacaggtgt acaccctgcc cccatcccag gaggagatga ccaagaacca ggtcagcctg     1140

acctgcctgg tcaaaggctt ctaccccagc gacatcgccg tggagtggga gagcaatggg     1200

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1260

ctctacagca ggctaaccgt ggacaagagc aggtggcagg aggggaatgt cttctcatgc     1320

tccgtgatgc atgaggctct gcacaaccac tacacacaga agagcctctc cctgtctctg     1380

ggtaaagcta gcgatacaac agaacctgca acacctacaa cacctgtaac aacaccgaca     1440

acaacacttc tagcgcccct catcctgtct cggattgtgg gaggctggga gtgcgagaag     1500

cattcccaac cctggcaggt gcttgtggcc tctcgtggca gggcagtctg cggcggtgtt     1560

ctggtgcacc cccagtgggt cctcacagct gcccactgca tcaggaacaa aagcgtgatc     1620

ttgctgggtc ggcacagcct gtttcatcct gaagacacag gccaggtatt tcaggtcagc     1680

cacagcttcc cacacccgct ctacgatatg agcctcctga agaatcgatt cctcaggcca     1740

ggtgatgact ccagccacga cctcatgctg ctccgcctgt cagagcctgc cgagctcacg     1800

gatgctgtga aggtcatgga cctgcccacc caggagccag cactggggac cacctgctac     1860

gcctcaggct ggggcagcat tgaaccagag gagttcttga ccccaaagaa acttcagtgt     1920

gtggacctcc atgttatttc caatgacgtg tgtgcgcaag ttcaccctca gaaggtgacc     1980

aagttcatgc tgtgtgctgg acgctggaca gggggcaaaa gcacctgctc gggtgattct     2040

gggggcccac ttgtctgtaa tggtgtgctt caaggtatca cgtcatgggg cagtgaacca     2100

tgtgccctgc ccgaaaggcc ttccctgtac accaaggtgg tgcattaccg gaagtggatc     2160

aaggacacca tcgtggccaa cccctga                                         2187


<210>  74
<211>  710
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  74

Gln Val Gln Leu Arg Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Ser Gly Tyr Ser Phe Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Tyr Tyr Asn Tyr Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Lys Thr Thr Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Ser Asp Thr 
        435                 440                 445             


Thr Glu Pro Ala Thr Pro Thr Thr Pro Val Thr Thr Pro Thr Thr Thr 
    450                 455                 460                 


Leu Leu Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys 
465                 470                 475                 480 


Glu Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg 
                485                 490                 495     


Ala Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala 
            500                 505                 510         


Ala His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser 
        515                 520                 525             


Leu Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser 
    530                 535                 540                 


Phe Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu 
545                 550                 555                 560 


Arg Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser 
                565                 570                 575     


Glu Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr 
            580                 585                 590         


Gln Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser 
        595                 600                 605             


Ile Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp 
    610                 615                 620                 


Leu His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys 
625                 630                 635                 640 


Val Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser 
                645                 650                 655     


Thr Cys Ser Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Gly Val Leu 
            660                 665                 670         


Gln Gly Ile Thr Ser Trp Gly Ser Glu Pro Cys Ala Leu Pro Glu Arg 
        675                 680                 685             


Pro Ser Leu Tyr Thr Lys Val Val His Tyr Arg Lys Trp Ile Lys Asp 
    690                 695                 700                 


Thr Ile Val Ala Asn Pro 
705                 710 


<210>  75
<211>  2268
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Syntehtic oligonucleotide.

<400>  75
atggaatgga ggatctttct cttcatcctg tcaggaactg caggtgtcca ctcccaggtt       60

cagctgcggc agtctggacc tgagctggtg aagcctgggg cttcagtgaa gatgtcctgc      120

aaggcttctg gatacacatt tactgactat gttataagtt gggtgaagca gagaactgga      180

cagggccttg agtggattgg agatatttat cctggaagtg gttattcttt ctacaatgag      240

aacttcaagg gcaaggccac actgactgca gacaaatcct ccaccacagc ctacatgcag      300

ctcagcagcc tgacatctga ggactctgcg gtctatttct gtgcaaccta ctataactac      360

ccttttgctt actggggcca agggactctg gtcactgtct ctgcagccaa aacaacgggc      420

ccatccgtct tccccctggc gccctgctcc aggagcacct ccgagagcac agccgccctg      480

ggctgcctgg tcaaggacta cttccccgaa ccggtgacgg tgtcgtggaa ctcaggcgcc      540

ctgaccagcg gcgtgcacac cttcccggct gtcctacagt cctcaggact ctactccctc      600

agcagcgtgg tgaccgtgcc ctccagcagc ttgggcacga agacctacac ctgcaacgta      660

gatcacaagc ccagcaacac caaggtggac aagagagttg agtccaaata tggtccccca      720

tgcccaccct gcccagcacc tgagttcgaa gggggaccat cagtcttcct gttcccccca      780

aaacccaagg acactctcat gatctcccgg acccctgagg tcacgtgcgt ggtggtggac      840

gtgagccagg aagaccccga ggtccagttc aactggtacg tggatggcgt ggaggtgcat      900

aatgccaaga caaagccgcg ggaggagcag ttcaacagca cgtaccgtgt ggtcagcgtc      960

ctcaccgtcc tgcaccagga ctggctgaac ggcaaggagt acaagtgcaa ggtctccaac     1020

aaaggcctcc cgtcctccat cgagaaaacc atctccaaag ccaaagggca gccccgagag     1080

ccacaggtgt acaccctgcc cccatcccag gaggagatga ccaagaacca ggtcagcctg     1140

acctgcctgg tcaaaggctt ctaccccagc gacatcgccg tggagtggga gagcaatggg     1200

cagccggaga acaactacaa gaccacgcct cccgtgctgg actccgacgg ctccttcttc     1260

ctctacagca ggctaaccgt ggacaagagc aggtggcagg aggggaatgt cttctcatgc     1320

tccgtgatgc atgaggctct gcacaaccac tacacacaga agagcctctc cctgtctctg     1380

ggtaaagcta gtcagacccc caccaacacc atcagcgtga cccccaccaa caacagcacc     1440

cccaccaaca acagcaaccc caagcccaac cccgctagtg agaagatccg gctgcggccc     1500

ggcggcaaga agaagtacaa gctgaagcac atcgtggcta gtagcagcgt gagccccacc     1560

accagcgtgc accccacccc caccagcgtg ccccccaccc ccaccaagag cagccccgct     1620

agtaaccccc ccatccccgt gggcgagatc tacaagcggt ggatcatcct gggcctgaac     1680

aagatcgtgc ggatgtacag ccccaccagc atcctggacg ctagtcccac cagcaccccc     1740

gccgacagca gcaccatcac ccccaccgcc acccccaccg ccacccccac catcaagggc     1800

gctagtcaca cccagggcta cttccccgac tggcagaact acacccccgg ccccggcgtg     1860

cggtaccccc tgaccttcgg ctggctgtac aagctggcta gtaccgtgac ccccaccgcc     1920

accgccaccc ccagcgccat cgtgaccacc atcaccccca ccgccaccac caagcccgct     1980

agtgtgggct tccccgtgac cccccaggtg cccctgcggc ccatgaccta caaggccgcc     2040

gtggacctga gccacttcct gaaggagaag ggcggcctgg ctagtaccaa cggcagcatc     2100

accgtggccg ccaccgcccc caccgtgacc cccaccgtga acgccacccc cagcgccgcc     2160

gctagtgcca tcttccagag cagcatgacc aagatcctgg agcccttccg gaagcagaac     2220

cccgacatcg tgatctacca gtacatggac gacctgtacg ctagctga                  2268


<210>  76
<211>  737
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  76

Gln Val Gln Leu Arg Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Asp Tyr 
            20                  25                  30          


Val Ile Ser Trp Val Lys Gln Arg Thr Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Asp Ile Tyr Pro Gly Ser Gly Tyr Ser Phe Tyr Asn Glu Asn Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Thr Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Phe Cys 
                85                  90                  95      


Ala Thr Tyr Tyr Asn Tyr Pro Phe Ala Tyr Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala Ala Lys Thr Thr Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser 
            180                 185                 190         


Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Glu Phe Glu Gly Gly Pro Ser Val Phe Leu Phe 
225                 230                 235                 240 


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
                245                 250                 255     


Thr Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe 
            260                 265                 270         


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
        275                 280                 285             


Arg Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
    290                 295                 300                 


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
305                 310                 315                 320 


Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala 
                325                 330                 335     


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln 
            340                 345                 350         


Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
        355                 360                 365             


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
    370                 375                 380                 


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
385                 390                 395                 400 


Phe Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu 
                405                 410                 415     


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
            420                 425                 430         


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys Ala Ser Gln Thr 
        435                 440                 445             


Pro Thr Asn Thr Ile Ser Val Thr Pro Thr Asn Asn Ser Thr Pro Thr 
    450                 455                 460                 


Asn Asn Ser Asn Pro Lys Pro Asn Pro Ala Ser Glu Lys Ile Arg Leu 
465                 470                 475                 480 


Arg Pro Gly Gly Lys Lys Lys Tyr Lys Leu Lys His Ile Val Ala Ser 
                485                 490                 495     


Ser Ser Val Ser Pro Thr Thr Ser Val His Pro Thr Pro Thr Ser Val 
            500                 505                 510         


Pro Pro Thr Pro Thr Lys Ser Ser Pro Ala Ser Asn Pro Pro Ile Pro 
        515                 520                 525             


Val Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys Ile 
    530                 535                 540                 


Val Arg Met Tyr Ser Pro Thr Ser Ile Leu Asp Ala Ser Pro Thr Ser 
545                 550                 555                 560 


Thr Pro Ala Asp Ser Ser Thr Ile Thr Pro Thr Ala Thr Pro Thr Ala 
                565                 570                 575     


Thr Pro Thr Ile Lys Gly Ala Ser His Thr Gln Gly Tyr Phe Pro Asp 
            580                 585                 590         


Trp Gln Asn Tyr Thr Pro Gly Pro Gly Val Arg Tyr Pro Leu Thr Phe 
        595                 600                 605             


Gly Trp Leu Tyr Lys Leu Ala Ser Thr Val Thr Pro Thr Ala Thr Ala 
    610                 615                 620                 


Thr Pro Ser Ala Ile Val Thr Thr Ile Thr Pro Thr Ala Thr Thr Lys 
625                 630                 635                 640 


Pro Ala Ser Val Gly Phe Pro Val Thr Pro Gln Val Pro Leu Arg Pro 
                645                 650                 655     


Met Thr Tyr Lys Ala Ala Val Asp Leu Ser His Phe Leu Lys Glu Lys 
            660                 665                 670         


Gly Gly Leu Ala Ser Thr Asn Gly Ser Ile Thr Val Ala Ala Thr Ala 
        675                 680                 685             


Pro Thr Val Thr Pro Thr Val Asn Ala Thr Pro Ser Ala Ala Ala Ser 
    690                 695                 700                 


Ala Ile Phe Gln Ser Ser Met Thr Lys Ile Leu Glu Pro Phe Arg Lys 
705                 710                 715                 720 


Gln Asn Pro Asp Ile Val Ile Tyr Gln Tyr Met Asp Asp Leu Tyr Ala 
                725                 730                 735     


Ser 
    


<210>  77
<211>  708
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide.

<400>  77
atggattttc aagtgcagat tttcagcttc ctgctaatca gtgcttcagt cataatgtcc       60

agaggacaaa ttgttctctc ccagtctcca gcaatcctgt ctgcatctcc aggggagaag      120

gtcacaatga cttgcagggc cagctcaagt gtaagttaca tgcactggta ccagcggaag      180

ccaggatcct cccccaaacc ctggatttat gccacatcca acctggcttc tggagtccct      240

gctcgcttca gtggcagtgg gtctgggacc tcttattctc tcacaatcag cagagtggag      300

gctgaagatg ctgccactta ttactgccag cagtggagta gtaacccgct cacgttcggt      360

gctgggacca agctggagct gaaacgggct gatgctgcac caactgtatc catcttccca      420

ccatccagtg agcagttaac atctggaggt gcctcagtcg tgtgcttctt gaacaacttc      480

taccccaaag acatcaatgt caagtggaag attgatggca gtgaacgaca aaatggcgtc      540

ctgaacagtt ggactgatca ggacagcaaa gacagcacct acagcatgag cagcaccctc      600

acgttgacca aggacgagta tgaacgacat aacagctata cctgtgaggc cactcacaag      660

acatcaactt cacccatcgt caagagcttc aacaggaatg agtgttag                   708


<210>  78
<211>  213
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  78

Gln Ile Val Leu Ser Gln Ser Pro Ala Ile Leu Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Arg Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Arg Lys Pro Gly Ser Ser Pro Lys Pro Trp Ile Tyr 
        35                  40                  45              


Ala Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Arg Val Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Ser Ser Asn Pro Leu Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala Pro 
            100                 105                 110         


Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser Gly Gly 
        115                 120                 125             


Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Lys Asp Ile Asn 
    130                 135                 140                 


Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val Leu Asn 
145                 150                 155                 160 


Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met Ser Ser 
                165                 170                 175     


Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser Tyr Thr 
            180                 185                 190         


Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys Ser Phe 
        195                 200                 205             


Asn Arg Asn Glu Cys 
    210             


<210>  79
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic oligonucleotide.

<400>  79
atggaatgga gctgggtctt tctcttcctc ctgtcagtaa ttgcaggtgt ccaatcccag       60

gttcagctgc agcagtctgg ggctgagctg gtgaggcctg gggcttcagt gacgctgtcc      120

tgcaaggctt cgggctacac atttattgac catgatatgc actgggtgca gcagacacct      180

gtgtatggcc tggaatggat cggagctatt gatcctgaaa ctggtgatac tggctacaat      240

cagaagttca agggcaaggc catactgact gcagacaaat cctccaggac agcctacatg      300

gaactccgca gcctgacatc tgaggactct gccgtctatt actgtacaat ccccttctac      360

tatagtaact acagcccgtt tgcttactgg ggccaagggg ctctggtcac tgtctctgca      420

gccaaaacaa cagccccatc ggtctatcca ctggcccctg tgtgtggagg tacaactggc      480

tcctcggtga ctctaggatg cctggtcaag ggttatttcc ctgagccagt gaccttgacc      540

tggaactctg gatccctgtc cagtggtgtg cacaccttcc cagctctcct gcagtctggc      600

ctctacaccc tcagcagctc agtgactgta acctcgaaca cctggcccag ccagaccatc      660

acctgcaatg tggcccaccc ggcaagcagc accaaagtgg acaagaaaat tgagcccaga      720

gtgcccataa cacagaaccc ctgtcctcca ctcaaagagt gtcccccatg cgcagacctc      780

ttgggtggac catccgtctt catcttccct ccaaagatca aggatgtact catgatctcc      840

ctgagcccca tggtcacatg tgtggtggtg gatgtgagcg aggatgaccc agacgcccag      900

atcagctggt ttgtgaacaa cgtggaagta cacacagctc agacacaaac ccatagagag      960

gattacaaca gtactctccg ggtggtcagt gccctcccca tccagcacca ggactggatg     1020

agtggcaagg agttcaaatg caaggtcaac aacagagccc tcccatcccc catcgagaaa     1080

accatctcaa aacccagagg gccagtaaga gctccacagg tatatgtctt gcctccacca     1140

gcagaagaga tgactaagaa agagttcagt ctgacctgca tgatcacagg cttcttacct     1200

gccgaaattg ctgtggactg gaccagcaat gggcgtacag agcaaaacta caagaacacc     1260

gcaacagtcc tggactctga tggttcttac ttcatgtaca gcaagctcag agtacaaaag     1320

agcacttggg aaagaggaag tcttttcgcc tgctcagtgg tccacgaggg tctgcacaat     1380

caccttacga ctaagaccat ctcccggtct ctgggtaaag ctagctga                  1428


<210>  80
<211>  456
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic peptide.

<400>  80

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Thr Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ile Asp His 
            20                  25                  30          


Asp Met His Trp Val Gln Gln Thr Pro Val Tyr Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Ile Asp Pro Glu Thr Gly Asp Thr Gly Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Ile Leu Thr Ala Asp Lys Ser Ser Arg Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Thr Ile Pro Phe Tyr Tyr Ser Asn Tyr Ser Pro Phe Ala Tyr Trp Gly 
            100                 105                 110         


Gln Gly Ala Leu Val Thr Val Ser Ala Ala Lys Thr Thr Ala Pro Ser 
        115                 120                 125             


Val Tyr Pro Leu Ala Pro Val Cys Gly Gly Thr Thr Gly Ser Ser Val 
    130                 135                 140                 


Thr Leu Gly Cys Leu Val Lys Gly Tyr Phe Pro Glu Pro Val Thr Leu 
145                 150                 155                 160 


Thr Trp Asn Ser Gly Ser Leu Ser Ser Gly Val His Thr Phe Pro Ala 
                165                 170                 175     


Leu Leu Gln Ser Gly Leu Tyr Thr Leu Ser Ser Ser Val Thr Val Thr 
            180                 185                 190         


Ser Asn Thr Trp Pro Ser Gln Thr Ile Thr Cys Asn Val Ala His Pro 
        195                 200                 205             


Ala Ser Ser Thr Lys Val Asp Lys Lys Ile Glu Pro Arg Val Pro Ile 
    210                 215                 220                 


Thr Gln Asn Pro Cys Pro Pro Leu Lys Glu Cys Pro Pro Cys Ala Asp 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp 
                245                 250                 255     


Val Leu Met Ile Ser Leu Ser Pro Met Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser Glu Asp Asp Pro Asp Ala Gln Ile Ser Trp Phe Val Asn Asn 
        275                 280                 285             


Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn 
    290                 295                 300                 


Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp 
305                 310                 315                 320 


Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Arg Ala Leu Pro 
                325                 330                 335     


Ser Pro Ile Glu Lys Thr Ile Ser Lys Pro Arg Gly Pro Val Arg Ala 
            340                 345                 350         


Pro Gln Val Tyr Val Leu Pro Pro Pro Ala Glu Glu Met Thr Lys Lys 
        355                 360                 365             


Glu Phe Ser Leu Thr Cys Met Ile Thr Gly Phe Leu Pro Ala Glu Ile 
    370                 375                 380                 


Ala Val Asp Trp Thr Ser Asn Gly Arg Thr Glu Gln Asn Tyr Lys Asn 
385                 390                 395                 400 


Thr Ala Thr Val Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys 
                405                 410                 415     


Leu Arg Val Gln Lys Ser Thr Trp Glu Arg Gly Ser Leu Phe Ala Cys 
            420                 425                 430         


Ser Val Val His Glu Gly Leu His Asn His Leu Thr Thr Lys Thr Ile 
        435                 440                 445             


Ser Arg Ser Leu Gly Lys Ala Ser 
    450                 455     


