                         SEQUENCE LISTING

<110>  The Salk Institute for Biological Studies
       Sugii, Shigeki
       Evans, Ronald M.
       Izpisua Belmonte, Juan Carlos
 
<120>  Adipose-Derived Induced Pluripotent Stem Cells

<130>  027731-003310PC

<150>  US 61/241,122
<151>  2009-09-10

<150>  US 61/298,164
<151>  2010-01-25

<160>  72    

<170>  PatentIn version 3.5

<210>  1
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for mouse Nanog

<400>  1
gcaagcggtg gcagaaaaac                                                   20


<210>  2
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for mouse Nanog

<400>  2
gcaatggatg ctgggatact cc                                                22


<210>  3
<211>  26
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for mouse Klf4

<400>  3
atctcaaggc acacctgcga actcac                                            26


<210>  4
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for mouse Klf4

<400>  4
cacacttctg gcactgaaag gg                                                22


<210>  5
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for mouse Lin28

<400>  5
gaacatgcag aagcgaagat cc                                                22


<210>  6
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for mouse Lin28

<400>  6
gttgatgctt tggcaaaagt gg                                                22


<210>  7
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for mouse Cct4

<400>  7
gttggagaag gtggaaccaa                                                   20


<210>  8
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for mouse Cct4

<400>  8
ctccttctgc agggctttc                                                    19


<210>  9
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for mouse Sox2

<400>  9
acagctacgc gcacatga                                                     18


<210>  10
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for mouse Sox2

<400>  10
ggtagcccag ctgctcct                                                     18


<210>  11
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for mouse cMyc

<400>  11
cctagtgctg catgaggaga                                                   20


<210>  12
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for mouse cMyc

<400>  12
tccacagaca ccacatcaat tt                                                22


<210>  13
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for mouse FGF2

<400>  13
cggctctact gcaagaacg                                                    19


<210>  14
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for mouse FGF2

<400>  14
tgcttggagt tgtagtttga cg                                                22


<210>  15
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for mouse TGF-beta-1

<400>  15
tggagcaaca tgtggaactc                                                   20


<210>  16
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for mouse TGF-beta-1

<400>  16
cagcagccgg ttaccaag                                                     18


<210>  17
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for mouse fibronectin

<400>  17
cggagagagt gcccctacta                                                   20


<210>  18
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for mouse fibronectin

<400>  18
cgatattggt gaatcgcaga                                                   20


<210>  19
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for mouse vitronectin

<400>  19
ctggggcaga tcctctgat                                                    19


<210>  20
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for mouse vitronectin

<400>  20
actttccctg gcacaccat                                                    19


<210>  21
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for mouse Activin A

<400>  21
atcatcacct ttgccgagtc                                                   20


<210>  22
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for mouse Activin A

<400>  22
acaggtcact gccttccttg                                                   20


<210>  23
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for mouse LIF

<400>  23
cccagggatt tccaggtact                                                   20


<210>  24
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for mouse LIF

<400>  24
tcaactttgc cagattccat c                                                 21


<210>  25
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for human Nanog

<400>  25
ccaacatcct gaacctcagc                                                   20


<210>  26
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for human Nanog

<400>  26
gctattcttc ggccagttg                                                    19


<210>  27
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for human Klf4

<400>  27
gggagaagac actgcgtca                                                    19


<210>  28
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for human Klf4

<400>  28
ggaagcactg ggggaagt                                                     18


<210>  29
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for human Lin28

<400>  29
gaagcgcaga tcaaaaggag                                                   20


<210>  30
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for human Lin28

<400>  30
gctgatgctc tggcagaagt                                                   20


<210>  31
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for human Oct4

<400>  31
gcaaaacccg gaggagtc                                                     18


<210>  32
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for human Oct4

<400>  32
ccacatcggc ctgtgtatat c                                                 21


<210>  33
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for human Sox2

<400>  33
ttgctgcctc tttaagacta gga                                               23


<210>  34
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for human Sox2

<400>  34
ctggggctca aacttctctc                                                   20


<210>  35
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer human cMyc

<400>  35
caccagcagc gactctga                                                     18


<210>  36
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer human cMyc

<400>  36
gatccagact ctgacctttt gc                                                22


<210>  37
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for human Zfp42

<400>  37
gcgtcataag gggtgagttt t                                                 21


<210>  38
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for human Zfp42

<400>  38
agaacattca agggagcttg c                                                 21


<210>  39
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for human Dppa2

<400>  39
tggtgtcaac aactcggttt g                                                 21


<210>  40
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for human Dppa2

<400>  40
ctcgaacatc gctgtaatct gg                                                22


<210>  41
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for human GATA2

<400>  41
aaggctcgtt cctgttcaga                                                   20


<210>  42
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 53 end primer for human GATA2

<400>  42
ggcattgcac aggtagtgg                                                    19


<210>  43
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for human Nestin

<400>  43
tgcgggctac tgaaaagttc                                                   20


<210>  44
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for human Nestin

<400>  44
tgtaggccct gtttctcctg                                                   20


<210>  45
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for human SMA

<400>  45
ctgttccagc catccttcat                                                   20


<210>  46
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for human SMA

<400>  46
tcatgatgct gttgtaggtg gt                                                22


<210>  47
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for human Actinin

<400>  47
gacgtggcag agaagtacct g                                                 21


<210>  48
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for human Actinin

<400>  48
ggcagttcca acgatgtctt                                                   20


<210>  49
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for human AFP

<400>  49
aagaatttca gcatgatttt cca                                               23


<210>  50
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for human AFP

<400>  50
cacccacttc atggttgcta                                                   20


<210>  51
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for human Sox7

<400>  51
gagcagtgtg gacacgtacc                                                   20


<210>  52
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for human Sox7

<400>  52
gtccagggga gacatttcag                                                   20


<210>  53
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for human PDX1

<400>  53
aagctcacgc gtggaaag                                                     18


<210>  54
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 53 end primer for human PDX1

<400>  54
gccgtgagat gtacttgttg aa                                                22


<210>  55
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for human FGF2

<400>  55
ttcttcctgc gcatccac                                                     18


<210>  56
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for human FGF2

<400>  56
tgcttgaagt tgtagcttga tgt                                               23


<210>  57
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for human TGF-beta-1

<400>  57
gcagcacgtg gagctgta                                                     18


<210>  58
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for human TGF-beta-1

<400>  58
cagccggttg ctgaggta                                                     18


<210>  59
<211>  22
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for human fibronectin

<400>  59
ctggccgaaa atacattgta aa                                                22


<210>  60
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for human fibronectin

<400>  60
ccacagtcgg gtcaggag                                                     18


<210>  61
<211>  18
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for human vitronectin

<400>  61
tgagtgcaag ccccaagt                                                     18


<210>  62
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for human vitronectin

<400>  62
gccatcgtca tagaccgtgt                                                   20


<210>  63
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for human activin A

<400>  63
ctcggagatc atcacgtttg                                                   20


<210>  64
<211>  20
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for human activin A

<400>  64
ccttggaaat ctcgaagtgc                                                   20


<210>  65
<211>  23
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 5' end primer for LTR of retrovirus 
       construct

<400>  65
ggaatgaaag accccacctg tag                                               23


<210>  66
<211>  24
<212>  DNA
<213>  Artificial

<220>
<223>  Synthetic DNA construct for 3' end primer for LTR of retrovirus 
       construct

<400>  66
gcgagaagcg aactgattgg ttag                                              24


<210>  67
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  67

Met Ala Gly His Leu Ala Ser Asp Phe Ala Phe Ser Pro Pro Pro Gly 
1               5                   10                  15      


Gly Gly Gly Asp Gly Pro Gly Gly Pro Glu Pro Gly Trp Val Asp Pro 
            20                  25                  30          


Arg Thr Trp Leu Ser Phe Gln Gly Pro Pro Gly Gly Pro Gly Ile Gly 
        35                  40                  45              


Pro Gly Val Gly Pro Gly Ser Glu Val Trp Gly Ile Pro Pro Cys Pro 
    50                  55                  60                  


Pro Pro Tyr Glu Phe Cys Gly Gly Met Ala Tyr Cys Gly Pro Gln Val 
65                  70                  75                  80  


Gly Val Gly Leu Val Pro Gln Gly Gly Leu Glu Thr Ser Gln Pro Glu 
                85                  90                  95      


Gly Glu Ala Gly Val Gly Val Glu Ser Asn Ser Asp Gly Ala Ser Pro 
            100                 105                 110         


Glu Pro Cys Thr Val Thr Pro Gly Ala Val Lys Leu Glu Lys Glu Lys 
        115                 120                 125             


Leu Glu Gln Asn Pro Glu Glu Ser Gln Asp Ile Lys Ala Leu Gln Lys 
    130                 135                 140                 


Glu Leu Glu Gln Phe Ala Lys Leu Leu Lys Gln Lys Arg Ile Thr Leu 
145                 150                 155                 160 


Gly Tyr Thr Gln Ala Asp Val Gly Leu Thr Leu Gly Val Leu Phe Gly 
                165                 170                 175     


Lys Val Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln Leu 
            180                 185                 190         


Ser Phe Lys Asn Met Cys Lys Leu Arg Pro Leu Leu Gln Lys Trp Val 
        195                 200                 205             


Glu Glu Ala Asp Asn Asn Glu Asn Leu Gln Glu Ile Cys Lys Ala Glu 
    210                 215                 220                 


Thr Leu Val Gln Ala Arg Lys Arg Lys Arg Thr Ser Ile Glu Asn Arg 
225                 230                 235                 240 


Val Arg Gly Asn Leu Glu Asn Leu Phe Leu Gln Cys Pro Lys Pro Thr 
                245                 250                 255     


Leu Gln Gln Ile Ser His Ile Ala Gln Gln Leu Gly Leu Glu Lys Asp 
            260                 265                 270         


Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Gly Lys Arg Ser 
        275                 280                 285             


Ser Ser Asp Tyr Ala Gln Arg Glu Asp Phe Glu Ala Ala Gly Ser Pro 
    290                 295                 300                 


Phe Ser Gly Gly Pro Val Ser Phe Pro Leu Ala Pro Gly Pro His Phe 
305                 310                 315                 320 


Gly Thr Pro Gly Tyr Gly Ser Pro His Phe Thr Ala Leu Tyr Ser Ser 
                325                 330                 335     


Val Pro Phe Pro Glu Gly Glu Ala Phe Pro Pro Val Ser Val Thr Thr 
            340                 345                 350         


Leu Gly Ser Pro Met His Ser Asn 
        355                 360 


<210>  68
<211>  265
<212>  PRT
<213>  Homo sapiens

<400>  68

Met His Phe Tyr Arg Leu Phe Leu Gly Ala Thr Arg Arg Phe Leu Asn 
1               5                   10                  15      


Pro Glu Trp Lys Gly Glu Ile Asp Asn Trp Cys Val Tyr Val Leu Thr 
            20                  25                  30          


Ser Leu Leu Pro Phe Lys Ile Gln Ser Gln Asp Ile Lys Ala Leu Gln 
        35                  40                  45              


Lys Glu Leu Glu Gln Phe Ala Lys Leu Leu Lys Gln Lys Arg Ile Thr 
    50                  55                  60                  


Leu Gly Tyr Thr Gln Ala Asp Val Gly Leu Thr Leu Gly Val Leu Phe 
65                  70                  75                  80  


Gly Lys Val Phe Ser Gln Thr Thr Ile Cys Arg Phe Glu Ala Leu Gln 
                85                  90                  95      


Leu Ser Phe Lys Asn Met Cys Lys Leu Arg Pro Leu Leu Gln Lys Trp 
            100                 105                 110         


Val Glu Glu Ala Asp Asn Asn Glu Asn Leu Gln Glu Ile Cys Lys Ala 
        115                 120                 125             


Glu Thr Leu Val Gln Ala Arg Lys Arg Lys Arg Thr Ser Ile Glu Asn 
    130                 135                 140                 


Arg Val Arg Gly Asn Leu Glu Asn Leu Phe Leu Gln Cys Pro Lys Pro 
145                 150                 155                 160 


Thr Leu Gln Gln Ile Ser His Ile Ala Gln Gln Leu Gly Leu Glu Lys 
                165                 170                 175     


Asp Val Val Arg Val Trp Phe Cys Asn Arg Arg Gln Lys Gly Lys Arg 
            180                 185                 190         


Ser Ser Ser Asp Tyr Ala Gln Arg Glu Asp Phe Glu Ala Ala Gly Ser 
        195                 200                 205             


Pro Phe Ser Gly Gly Pro Val Ser Phe Pro Leu Ala Pro Gly Pro His 
    210                 215                 220                 


Phe Gly Thr Pro Gly Tyr Gly Ser Pro His Phe Thr Ala Leu Tyr Ser 
225                 230                 235                 240 


Ser Val Pro Phe Pro Glu Gly Glu Ala Phe Pro Pro Val Ser Val Thr 
                245                 250                 255     


Thr Leu Gly Ser Pro Met His Ser Asn 
            260                 265 


<210>  69
<211>  190
<212>  PRT
<213>  Homo sapiens

<400>  69

Met Gly Val Leu Phe Gly Lys Val Phe Ser Gln Thr Thr Ile Cys Arg 
1               5                   10                  15      


Phe Glu Ala Leu Gln Leu Ser Phe Lys Asn Met Cys Lys Leu Arg Pro 
            20                  25                  30          


Leu Leu Gln Lys Trp Val Glu Glu Ala Asp Asn Asn Glu Asn Leu Gln 
        35                  40                  45              


Glu Ile Cys Lys Ala Glu Thr Leu Val Gln Ala Arg Lys Arg Lys Arg 
    50                  55                  60                  


Thr Ser Ile Glu Asn Arg Val Arg Gly Asn Leu Glu Asn Leu Phe Leu 
65                  70                  75                  80  


Gln Cys Pro Lys Pro Thr Leu Gln Gln Ile Ser His Ile Ala Gln Gln 
                85                  90                  95      


Leu Gly Leu Glu Lys Asp Val Val Arg Val Trp Phe Cys Asn Arg Arg 
            100                 105                 110         


Gln Lys Gly Lys Arg Ser Ser Ser Asp Tyr Ala Gln Arg Glu Asp Phe 
        115                 120                 125             


Glu Ala Ala Gly Ser Pro Phe Ser Gly Gly Pro Val Ser Phe Pro Leu 
    130                 135                 140                 


Ala Pro Gly Pro His Phe Gly Thr Pro Gly Tyr Gly Ser Pro His Phe 
145                 150                 155                 160 


Thr Ala Leu Tyr Ser Ser Val Pro Phe Pro Glu Gly Glu Ala Phe Pro 
                165                 170                 175     


Pro Val Ser Val Thr Thr Leu Gly Ser Pro Met His Ser Asn 
            180                 185                 190 


<210>  70
<211>  317
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Tyr Asn Met Met Glu Thr Glu Leu Lys Pro Pro Gly Pro Gln Gln 
1               5                   10                  15      


Thr Ser Gly Gly Gly Gly Gly Asn Ser Thr Ala Ala Ala Ala Gly Gly 
            20                  25                  30          


Asn Gln Lys Asn Ser Pro Asp Arg Val Lys Arg Pro Met Asn Ala Phe 
        35                  40                  45              


Met Val Trp Ser Arg Gly Gln Arg Arg Lys Met Ala Gln Glu Asn Pro 
    50                  55                  60                  


Lys Met His Asn Ser Glu Ile Ser Lys Arg Leu Gly Ala Glu Trp Lys 
65                  70                  75                  80  


Leu Leu Ser Glu Thr Glu Lys Arg Pro Phe Ile Asp Glu Ala Lys Arg 
                85                  90                  95      


Leu Arg Ala Leu His Met Lys Glu His Pro Asp Tyr Lys Tyr Arg Pro 
            100                 105                 110         


Arg Arg Lys Thr Lys Thr Leu Met Lys Lys Asp Lys Tyr Thr Leu Pro 
        115                 120                 125             


Gly Gly Leu Leu Ala Pro Gly Gly Asn Ser Met Ala Ser Gly Val Gly 
    130                 135                 140                 


Val Gly Ala Gly Leu Gly Ala Gly Val Asn Gln Arg Met Asp Ser Tyr 
145                 150                 155                 160 


Ala His Met Asn Gly Trp Ser Asn Gly Ser Tyr Ser Met Met Gln Asp 
                165                 170                 175     


Gln Leu Gly Tyr Pro Gln His Pro Gly Leu Asn Ala His Gly Ala Ala 
            180                 185                 190         


Gln Met Gln Pro Met His Arg Tyr Asp Val Ser Ala Leu Gln Tyr Asn 
        195                 200                 205             


Ser Met Thr Ser Ser Gln Thr Tyr Met Asn Gly Ser Pro Thr Tyr Ser 
    210                 215                 220                 


Met Ser Tyr Ser Gln Gln Gly Thr Pro Gly Met Ala Leu Gly Ser Met 
225                 230                 235                 240 


Gly Ser Val Val Lys Ser Glu Ala Ser Ser Ser Pro Pro Val Val Thr 
                245                 250                 255     


Ser Ser Ser His Ser Arg Ala Pro Cys Gln Ala Gly Asp Leu Arg Asp 
            260                 265                 270         


Met Ile Ser Met Tyr Leu Pro Gly Ala Glu Val Pro Glu Pro Ala Ala 
        275                 280                 285             


Pro Ser Arg Leu His Met Ser Gln His Tyr Gln Ser Gly Pro Val Pro 
    290                 295                 300                 


Gly Thr Ala Ile Asn Gly Thr Leu Pro Leu Ser His Met 
305                 310                 315         


<210>  71
<211>  479
<212>  PRT
<213>  Homo sapiens

<400>  71

Met Arg Gln Pro Pro Gly Glu Ser Asp Met Ala Val Ser Asp Ala Leu 
1               5                   10                  15      


Leu Pro Ser Phe Ser Thr Phe Ala Ser Gly Pro Ala Gly Arg Glu Lys 
            20                  25                  30          


Thr Leu Arg Gln Ala Gly Ala Pro Asn Asn Arg Trp Arg Glu Glu Leu 
        35                  40                  45              


Ser His Met Lys Arg Leu Pro Pro Val Leu Pro Gly Arg Pro Tyr Asp 
    50                  55                  60                  


Leu Ala Ala Ala Thr Val Ala Thr Asp Leu Glu Ser Gly Gly Ala Gly 
65                  70                  75                  80  


Ala Ala Cys Gly Gly Ser Asn Leu Ala Pro Leu Pro Arg Arg Glu Thr 
                85                  90                  95      


Glu Glu Phe Asn Asp Leu Leu Asp Leu Asp Phe Ile Leu Ser Asn Ser 
            100                 105                 110         


Leu Thr His Pro Pro Glu Ser Val Ala Ala Thr Val Ser Ser Ser Ala 
        115                 120                 125             


Ser Ala Ser Ser Ser Ser Ser Pro Ser Ser Ser Gly Pro Ala Ser Ala 
    130                 135                 140                 


Pro Ser Thr Cys Ser Phe Thr Tyr Pro Ile Arg Ala Gly Asn Asp Pro 
145                 150                 155                 160 


Gly Val Ala Pro Gly Gly Thr Gly Gly Gly Leu Leu Tyr Gly Arg Glu 
                165                 170                 175     


Ser Ala Pro Pro Pro Thr Ala Pro Phe Asn Leu Ala Asp Ile Asn Asp 
            180                 185                 190         


Val Ser Pro Ser Gly Gly Phe Val Ala Glu Leu Leu Arg Pro Glu Leu 
        195                 200                 205             


Asp Pro Val Tyr Ile Pro Pro Gln Gln Pro Gln Pro Pro Gly Gly Gly 
    210                 215                 220                 


Leu Met Gly Lys Phe Val Leu Lys Ala Ser Leu Ser Ala Pro Gly Ser 
225                 230                 235                 240 


Glu Tyr Gly Ser Pro Ser Val Ile Ser Val Ser Lys Gly Ser Pro Asp 
                245                 250                 255     


Gly Ser His Pro Val Val Val Ala Pro Tyr Asn Gly Gly Pro Pro Arg 
            260                 265                 270         


Thr Cys Pro Lys Ile Lys Gln Glu Ala Val Ser Ser Cys Thr His Leu 
        275                 280                 285             


Gly Ala Gly Pro Pro Leu Ser Asn Gly His Arg Pro Ala Ala His Asp 
    290                 295                 300                 


Phe Pro Leu Gly Arg Gln Leu Pro Ser Arg Thr Thr Pro Thr Leu Gly 
305                 310                 315                 320 


Leu Glu Glu Val Leu Ser Ser Arg Asp Cys His Pro Ala Leu Pro Leu 
                325                 330                 335     


Pro Pro Gly Phe His Pro His Pro Gly Pro Asn Tyr Pro Ser Phe Leu 
            340                 345                 350         


Pro Asp Gln Met Gln Pro Gln Val Pro Pro Leu His Tyr Gln Glu Leu 
        355                 360                 365             


Met Pro Pro Gly Ser Cys Met Pro Glu Glu Pro Lys Pro Lys Arg Gly 
    370                 375                 380                 


Arg Arg Ser Trp Pro Arg Lys Arg Thr Ala Thr His Thr Cys Asp Tyr 
385                 390                 395                 400 


Ala Gly Cys Gly Lys Thr Tyr Thr Lys Ser Ser His Leu Lys Ala His 
                405                 410                 415     


Leu Arg Thr His Thr Gly Glu Lys Pro Tyr His Cys Asp Trp Asp Gly 
            420                 425                 430         


Cys Gly Trp Lys Phe Ala Arg Ser Asp Glu Leu Thr Arg His Tyr Arg 
        435                 440                 445             


Lys His Thr Gly His Arg Pro Phe Gln Cys Gln Lys Cys Asp Arg Ala 
    450                 455                 460                 


Phe Ser Arg Ser Asp His Leu Ala Leu His Met Lys Arg His Phe 
465                 470                 475                 


<210>  72
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Asp Phe Phe Arg Val Val Glu Asn Gln Gln Pro Pro Ala Thr Met 
1               5                   10                  15      


Pro Leu Asn Val Ser Phe Thr Asn Arg Asn Tyr Asp Leu Asp Tyr Asp 
            20                  25                  30          


Ser Val Gln Pro Tyr Phe Tyr Cys Asp Glu Glu Glu Asn Phe Tyr Gln 
        35                  40                  45              


Gln Gln Gln Gln Ser Glu Leu Gln Pro Pro Ala Pro Ser Glu Asp Ile 
    50                  55                  60                  


Trp Lys Lys Phe Glu Leu Leu Pro Thr Pro Pro Leu Ser Pro Ser Arg 
65                  70                  75                  80  


Arg Ser Gly Leu Cys Ser Pro Ser Tyr Val Ala Val Thr Pro Phe Ser 
                85                  90                  95      


Leu Arg Gly Asp Asn Asp Gly Gly Gly Gly Ser Phe Ser Thr Ala Asp 
            100                 105                 110         


Gln Leu Glu Met Val Thr Glu Leu Leu Gly Gly Asp Met Val Asn Gln 
        115                 120                 125             


Ser Phe Ile Cys Asp Pro Asp Asp Glu Thr Phe Ile Lys Asn Ile Ile 
    130                 135                 140                 


Ile Gln Asp Cys Met Trp Ser Gly Phe Ser Ala Ala Ala Lys Leu Val 
145                 150                 155                 160 


Ser Glu Lys Leu Ala Ser Tyr Gln Ala Ala Arg Lys Asp Ser Gly Ser 
                165                 170                 175     


Pro Asn Pro Ala Arg Gly His Ser Val Cys Ser Thr Ser Ser Leu Tyr 
            180                 185                 190         


Leu Gln Asp Leu Ser Ala Ala Ala Ser Glu Cys Ile Asp Pro Ser Val 
        195                 200                 205             


Val Phe Pro Tyr Pro Leu Asn Asp Ser Ser Ser Pro Lys Ser Cys Ala 
    210                 215                 220                 


Ser Gln Asp Ser Ser Ala Phe Ser Pro Ser Ser Asp Ser Leu Leu Ser 
225                 230                 235                 240 


Ser Thr Glu Ser Ser Pro Gln Gly Ser Pro Glu Pro Leu Val Leu His 
                245                 250                 255     


Glu Glu Thr Pro Pro Thr Thr Ser Ser Asp Ser Glu Glu Glu Gln Glu 
            260                 265                 270         


Asp Glu Glu Glu Ile Asp Val Val Ser Val Glu Lys Arg Gln Ala Pro 
        275                 280                 285             


Gly Lys Arg Ser Glu Ser Gly Ser Pro Ser Ala Gly Gly His Ser Lys 
    290                 295                 300                 


Pro Pro His Ser Pro Leu Val Leu Lys Arg Cys His Val Ser Thr His 
305                 310                 315                 320 


Gln His Asn Tyr Ala Ala Pro Pro Ser Thr Arg Lys Asp Tyr Pro Ala 
                325                 330                 335     


Ala Lys Arg Val Lys Leu Asp Ser Val Arg Val Leu Arg Gln Ile Ser 
            340                 345                 350         


Asn Asn Arg Lys Cys Thr Ser Pro Arg Ser Ser Asp Thr Glu Glu Asn 
        355                 360                 365             


Val Lys Arg Arg Thr His Asn Val Leu Glu Arg Gln Arg Arg Asn Glu 
    370                 375                 380                 


Leu Lys Arg Ser Phe Phe Ala Leu Arg Asp Gln Ile Pro Glu Leu Glu 
385                 390                 395                 400 


Asn Asn Glu Lys Ala Pro Lys Val Val Ile Leu Lys Lys Ala Thr Ala 
                405                 410                 415     


Tyr Ile Leu Ser Val Gln Ala Glu Glu Gln Lys Leu Ile Ser Glu Glu 
            420                 425                 430         


Asp Leu Leu Arg Lys Arg Arg Glu Gln Leu Lys His Lys Leu Glu Gln 
        435                 440                 445             


Leu Arg Asn Ser Cys Ala 
    450                 


