                         SEQUENCE LISTING

<110>  Rockefeller University
 
<120>  METHODS OF IDENTIFYING ANTI-INFLAMMATORY COMPOUNDS

<130>  70413.20139/RU884

<140>  (filed herewith)
<141>  2010-09-08

<150>  US 61/242,224
<151>  2009-09-14

<160>  4     

<170>  PatentIn version 3.4

<210>  1
<211>  4266
<212>  DNA
<213>  Homo sapiens

<400>  1
tggggtgaca tgagtgactc caaggaacca agactgcagc agctgggcct cctggaggag     60

gaacagctga gaggccttgg attccgacag actcgaggat acaagagctt agcagggtgt    120

cttggccatg gtcccctggt gctgcaactc ctctccttca cgctcttggc tgggctcctt    180

gtccaagtgt ccaaggtccc cagctccata agtcaggaac aatccaggca agacgcgatc    240

taccagaacc tgacccagct taaagctgca gtgggtgagc tctcagagaa atccaagctg    300

caggagatct accaggagct gacccagctg aaggctgcag tgggtgagct tccagagaaa    360

tctaagctgc aggagatcta ccaggagctg acccggctga aggctgcagt gggtgagctt    420

ccagagaaat ctaagctgca ggagatctac caggagctga cctggctgaa ggctgcagtg    480

ggtgagcttc cagagaaatc taagatgcag gagatctacc aggagctgac tcggctgaag    540

gctgcagtgg gtgagcttcc agagaaatct aagcagcagg agatctacca ggagctgacc    600

cggctgaagg ctgcagtggg tgagcttcca gagaaatcta agcagcagga gatctaccag    660

gagctgaccc ggctgaaggc tgcagtgggt gagcttccag agaaatctaa gcagcaggag    720

atctaccagg agctgaccca gctgaaggct gcagtggaac gcctgtgcca cccctgtccc    780

tgggaatgga cattcttcca aggaaactgt tacttcatgt ctaactccca gcggaactgg    840

cacgactcca tcaccgcctg caaagaagtg ggggcccagc tcgtcgtaat caaaagtgct    900

gaggagcaga acttcctaca gctgcagtct tccagaagta accgcttcac ctggatggga    960

ctttcagatc taaatcagga aggcacgtgg caatgggtgg acggctcacc tctgttgccc   1020

agcttcaagc agtattggaa cagaggagag cccaacaacg ttggggagga agactgcgcg   1080

gaatttagtg gcaatggctg gaacgacgac aaatgtaatc ttgccaaatt ctggatctgc   1140

aaaaagtccg cagcctcctg ctccagggat gaagaacagt ttctttctcc agcccctgcc   1200

accccaaacc cccctcctgc gtagcagaac ttcaccccct tttaagctac agttccttct   1260

ctccatcctt cgaccttcac aaaatctctg ggactgttct ttgtcagatt cttcctcctt   1320

tagaaggctg ggtcccattc tgtccttctt gtcatgcctc caatttcccc tggtgtagag   1380

cttgtttttc tggcccatcc ttggagcttt atgagtgagc tggtgtggga tgcctttggg   1440

ggtggacttg tgttccaaga atccactctc tcttcctttt ggagattagg atatttgggt   1500

tgccatgtgt agctgctatg tcccctgggg cgttatctca tacatgcaaa cctaccatct   1560

gttcaacttc cacctaccac ctcctgcacc cctttgatcg gggacttact ggttgcaaga   1620

gctcattttg caggctggaa gcaccaggga attaattccc ccagtctacc aatggcaccc   1680

agagagggca tggaggctcc acgcaacccc ttccaccccc acatcttcct ttgtcttata   1740

catggcttcc atttggctgt ttctaagttg tattctttat tttattatta ttattactat   1800

ttttcgagat ggagtttcac tcttgtcgct caggctggag tgccatggcg cgatcttggc   1860

tcactgcaac ctctgcctcc cgggttcaag tgattctcct gcctcagcct cacgagtagc   1920

tggaattaca ggcaggcgcc accaggcccg gctaattttt tgtattttta gtacagacgg   1980

ggtttctccg tgttggtcag gctggtcttg aactcccgac ctcagatgat ctgcccgcct   2040

cggcctccca aaattgctgg gattacaggt gtgagccacc gcgcctggcc tattattttt   2100

tgtaagaata aaacaggttt actgggattt gggactctga acagttctgt ctctactacc   2160

tgatctcctc ctaccacgac tttgggatct agaggagctt tggctccggc tgtgacggct   2220

ccggccgttc tcactgcggc tgcaccggcc cccgctgcgg tcactatttc ttcctctgct   2280

tggtgaattg tgcctctcct ggctctttga catgtgctag tgagatttct tccttttcct   2340

ttcggattcc ccatttcttt tgtaggaatg gtctggacta gggttctcct tccccgcagc   2400

ctgtagtatt catcgtggtg gcccatcctc tctctcccct tggagctctt gccaaaggag   2460

gagacaagca gaggtctcta ttggatttct caacacctga agaaagttgc agtgttttcc   2520

tcttggacat tgttgtattt caaataaacc acaaatcatc attttccacc gagccactgg   2580

gcagaattca cactgaagct gtcgtcctgc gtacatacca tcgtccgtta aacagagaaa   2640

gagctgcttg gcattcttct tccgactggt actgaacata tatacttgcc cctcaggtga   2700

ggttccaagt tgcaactgac cttgaactga atcactctcc ccacgttatt ttttaattac   2760

tatttttttt taaagatggg gtcttgctct gtcgccaggc tggagtgcag tggcgcgatc   2820

taggctcact gcaacttccg cctcccgggt tcaagcgatt ctcctgcctc agcctcccga   2880

gtagctggga ctctactaaa agtacaaaaa ttagctggcg tgcaccaccg cgcccagcta   2940

attcttgtat ttttggtaga gacggggttt caacatgttg accaggatgg tctcgatctc   3000

ttgacctcgt gattcgcccg ccgcgtcctc ccaaagtgct gggattacag gcctgagcca   3060

ccgcgcccag tctctcccca cgttcttgaa ctcgggcagc acatcctcac agaaatctag   3120

gaactgttgg taggtttctt cctcgctgta ctccaggctt gcttcggagt catagtcatc   3180

cctcctgcac tgctcctttc caaacactgt aaacatgctt ttaataagaa gggtaggact   3240

ggatgttggg aaatcatgtg aacatctatc tccaaatctg caagctcctg ttttactgta   3300

gaagggacaa ttaactccat ccttctccat gactctgaaa tccaaggggg ggttccgggt   3360

tttgccatgt ggcgccattt tccaactcat tttcagcctg atccagcatc ttctggacag   3420

cttccggttt ttgtttcttc tgtcgtttct gttcctcctc ctctctctct ttcctctgct   3480

gttcttccca ttgttccttt aactttcgct cttgttcttg ccgttttcta gccacctctt   3540

ccttttcctt ctttattctg aattcttctt gtgccttctg ctctctcagc aaccactcct   3600

catgtaatct ttgcctctct cttccccata gcttttctag ttgttgtttt tcaataaaag   3660

tgtcctcctc tttctgtgag agtcctgagt ccctcagtgg agcaagttcc tgctggcgtt   3720

tctttcgttt ctccttcttc agggcggccc tgtacttttt gtggcttggt ttctctggaa   3780

atgtcacctt ttcgggcgca gccatcttgc cggcaccgcc ccgcccctct agttgtatcc   3840

tttataataa aatggtaaac attgtaaccg cagattcagc ccaatctggt tcaactttgt   3900

gtaataaaat ggcgagttgt ttttcagttg tcgtggaccc ccaggttgca agttacatac   3960

cctgggcatg tccagatgaa cgaagcgtgc aaatccacgt ggaacctaag tgctcagact   4020

gaggaacagg gactgagtta agaagtggac accacgtggc atgatccttg atccaatcag   4080

attgagccct ggcgtgatcc agtcagatca agcctcctga atcccctcat tacaagatcc   4140

aatcatatca tgcctcacta ccctctgtat ataaaatctg ccccagcctc caacttggag   4200

agacagattt gggccagact cctgtgtcct tgcttggctg ccttgcaata aatttttctc   4260

tctaca                                                              4266


<210>  2
<211>  404
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Ser Asp Ser Lys Glu Pro Arg Leu Gln Gln Leu Gly Leu Leu Glu 
1               5                   10                  15      


Glu Glu Gln Leu Arg Gly Leu Gly Phe Arg Gln Thr Arg Gly Tyr Lys 
            20                  25                  30          


Ser Leu Ala Gly Cys Leu Gly His Gly Pro Leu Val Leu Gln Leu Leu 
        35                  40                  45              


Ser Phe Thr Leu Leu Ala Gly Leu Leu Val Gln Val Ser Lys Val Pro 
    50                  55                  60                  


Ser Ser Ile Ser Gln Glu Gln Ser Arg Gln Asp Ala Ile Tyr Gln Asn 
65                  70                  75                  80  


Leu Thr Gln Leu Lys Ala Ala Val Gly Glu Leu Ser Glu Lys Ser Lys 
                85                  90                  95      


Leu Gln Glu Ile Tyr Gln Glu Leu Thr Gln Leu Lys Ala Ala Val Gly 
            100                 105                 110         


Glu Leu Pro Glu Lys Ser Lys Leu Gln Glu Ile Tyr Gln Glu Leu Thr 
        115                 120                 125             


Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Leu Gln 
    130                 135                 140                 


Glu Ile Tyr Gln Glu Leu Thr Trp Leu Lys Ala Ala Val Gly Glu Leu 
145                 150                 155                 160 


Pro Glu Lys Ser Lys Met Gln Glu Ile Tyr Gln Glu Leu Thr Arg Leu 
                165                 170                 175     


Lys Ala Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Gln Gln Glu Ile 
            180                 185                 190         


Tyr Gln Glu Leu Thr Arg Leu Lys Ala Ala Val Gly Glu Leu Pro Glu 
        195                 200                 205             


Lys Ser Lys Gln Gln Glu Ile Tyr Gln Glu Leu Thr Arg Leu Lys Ala 
    210                 215                 220                 


Ala Val Gly Glu Leu Pro Glu Lys Ser Lys Gln Gln Glu Ile Tyr Gln 
225                 230                 235                 240 


Glu Leu Thr Gln Leu Lys Ala Ala Val Glu Arg Leu Cys His Pro Cys 
                245                 250                 255     


Pro Trp Glu Trp Thr Phe Phe Gln Gly Asn Cys Tyr Phe Met Ser Asn 
            260                 265                 270         


Ser Gln Arg Asn Trp His Asp Ser Ile Thr Ala Cys Lys Glu Val Gly 
        275                 280                 285             


Ala Gln Leu Val Val Ile Lys Ser Ala Glu Glu Gln Asn Phe Leu Gln 
    290                 295                 300                 


Leu Gln Ser Ser Arg Ser Asn Arg Phe Thr Trp Met Gly Leu Ser Asp 
305                 310                 315                 320 


Leu Asn Gln Glu Gly Thr Trp Gln Trp Val Asp Gly Ser Pro Leu Leu 
                325                 330                 335     


Pro Ser Phe Lys Gln Tyr Trp Asn Arg Gly Glu Pro Asn Asn Val Gly 
            340                 345                 350         


Glu Glu Asp Cys Ala Glu Phe Ser Gly Asn Gly Trp Asn Asp Asp Lys 
        355                 360                 365             


Cys Asn Leu Ala Lys Phe Trp Ile Cys Lys Lys Ser Ala Ala Ser Cys 
    370                 375                 380                 


Ser Arg Asp Glu Glu Gln Phe Leu Ser Pro Ala Pro Ala Thr Pro Asn 
385                 390                 395                 400 


Pro Pro Pro Ala 
                


<210>  3
<211>  1220
<212>  DNA
<213>  Mus musculus

<400>  3
cccatgcacc aggggacagc ggcaaccatg agtgactcca cagaagccaa gatgcagcct     60

cttagctcca tggacgatga tgagttgatg gtcagcggca gcaggtattc tattaaaagc    120

tccagactac gaccaaattc tggaatcaag tgtttggcag gatgctcggg acacagccaa    180

gtccccttgg tcctgcagct gctctccttc ctgttcttgg ctgggctcct gctgatcatt    240

cttttccaag tctccaaaac cccaaatacc gagaggcaga aggaacaaga gaagatcctc    300

caggaactga cccagctgac agatgagctt acgtccagga tccccatctc ccaagggaag    360

aatgagtcca tgcaggcgaa gatcactgag caactgatgc agctgaaaac tgaactcttg    420

tccaggattc ccatcttcca ggggcagaat gagtccatac aagagaagat ctctgagcaa    480

ctgatgcagc tgaaggctga acttctttcc aagatctcca gcttcccggt aaaggatgat    540

tctaagcagg agaagatcta ccaacagctg gtacagatga agactgaact cttccgcctg    600

tgtcgactct gcccctggga ctggacattc ctcctaggaa attgttactt cttctccaag    660

tcccagcgga actggaatga cgccgtcaca gcttgcaaag aagtgaaggc tcaactagtc    720

atcatcaata gtgatgaaga gcagaccttc ctgcagcaga cttctaaggc taaaggacca    780

acctggatgg gcctgtcaga cctgaagaag gaggccacgt ggctctgggt agatggttct    840

actctgtcat ccagattcca gaaatattgg aatagagggg agcctaacaa catcggtgag    900

gaagactgtg tcgaatttgc tggggatggc tggaatgact ctaaatgtga actcaaaaag    960

ttctggatct gcaagaagtc tgcaacccca tgcactgaag gctagctcat ctccgctcct   1020

accttcatgc cattctgcca ggcacatgga tgtgcctcac tttcgtgcca gctccttctt   1080

cctgcctgtt ggcctcagga tcgtgaaaaa ggctctggga ttcttctttt tatcagattt   1140

ttcatcctct gcatttatca tagtttcatt tctgttgatg tgataaaact ctctaaaaaa   1200

aaaaaaaaaa aaaaaaaaaa                                               1220


<210>  4
<211>  325
<212>  PRT
<213>  Mus musculus

<400>  4

Met Ser Asp Ser Thr Glu Ala Lys Met Gln Pro Leu Ser Ser Met Asp 
1               5                   10                  15      


Asp Asp Glu Leu Met Val Ser Gly Ser Arg Tyr Ser Ile Lys Ser Ser 
            20                  25                  30          


Arg Leu Arg Pro Asn Ser Gly Ile Lys Cys Leu Ala Gly Cys Ser Gly 
        35                  40                  45              


His Ser Gln Val Pro Leu Val Leu Gln Leu Leu Ser Phe Leu Phe Leu 
    50                  55                  60                  


Ala Gly Leu Leu Leu Ile Ile Leu Phe Gln Val Ser Lys Thr Pro Asn 
65                  70                  75                  80  


Thr Glu Arg Gln Lys Glu Gln Glu Lys Ile Leu Gln Glu Leu Thr Gln 
                85                  90                  95      


Leu Thr Asp Glu Leu Thr Ser Arg Ile Pro Ile Ser Gln Gly Lys Asn 
            100                 105                 110         


Glu Ser Met Gln Ala Lys Ile Thr Glu Gln Leu Met Gln Leu Lys Thr 
        115                 120                 125             


Glu Leu Leu Ser Arg Ile Pro Ile Phe Gln Gly Gln Asn Glu Ser Ile 
    130                 135                 140                 


Gln Glu Lys Ile Ser Glu Gln Leu Met Gln Leu Lys Ala Glu Leu Leu 
145                 150                 155                 160 


Ser Lys Ile Ser Ser Phe Pro Val Lys Asp Asp Ser Lys Gln Glu Lys 
                165                 170                 175     


Ile Tyr Gln Gln Leu Val Gln Met Lys Thr Glu Leu Phe Arg Leu Cys 
            180                 185                 190         


Arg Leu Cys Pro Trp Asp Trp Thr Phe Leu Leu Gly Asn Cys Tyr Phe 
        195                 200                 205             


Phe Ser Lys Ser Gln Arg Asn Trp Asn Asp Ala Val Thr Ala Cys Lys 
    210                 215                 220                 


Glu Val Lys Ala Gln Leu Val Ile Ile Asn Ser Asp Glu Glu Gln Thr 
225                 230                 235                 240 


Phe Leu Gln Gln Thr Ser Lys Ala Lys Gly Pro Thr Trp Met Gly Leu 
                245                 250                 255     


Ser Asp Leu Lys Lys Glu Ala Thr Trp Leu Trp Val Asp Gly Ser Thr 
            260                 265                 270         


Leu Ser Ser Arg Phe Gln Lys Tyr Trp Asn Arg Gly Glu Pro Asn Asn 
        275                 280                 285             


Ile Gly Glu Glu Asp Cys Val Glu Phe Ala Gly Asp Gly Trp Asn Asp 
    290                 295                 300                 


Ser Lys Cys Glu Leu Lys Lys Phe Trp Ile Cys Lys Lys Ser Ala Thr 
305                 310                 315                 320 


Pro Cys Thr Glu Gly 
                325 


