                         SEQUENCE LISTING

<110>  CuRNA, Inc.
 
<120>  TREATMENT OF 'IQ MOTIF CONTAINING GTPASE ACTIVATING PROTEIN' 
       (IQGAP) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE 
       TRANSCRIPT TO IQGAP

<130>  IQGAP

<150>  US61/236,727
<151>  2009-08-25

<160>  7     

<170>  PatentIn version 3.5

<210>  1
<211>  5769
<212>  DNA
<213>  Homo sapiens

<300>
<308>  NM_006633
<309>  2010-08-04
<313>  (1)..(5769)

<400>  1
gagggaggag agttcacttt tacttcagtg tcagcgcgcg gcggccgtgg ctggctctgg       60

cgagagagca ccgagggagt gggtcgcaga tcttcgggcg gctaggggaa atcggcgaga      120

ggcgggatcc gagcgcgccg gcggggcgca gagcccgcga gcctggccag cgagggtagc      180

cgcggggggc gcgccccggg cgggcccccg gagacgcgca ggatgccaca cgaagagctg      240

ccgtcgctgc agagaccccg ctatggctct attgtggacg atgaaaggct ctctgcagag      300

gagatggatg agaggaggcg gcagaacatt gcttatgaat atctgtgcca cttagaggaa      360

gccaaaaggt ggatggaagt ttgcttagtt gaagaattgc caccaaccac tgaattggaa      420

gaagggctcc ggaatggagt ttaccttgca aagttagcca agttctttgc cccgaaaatg      480

gtatcagaga aaaagatcta tgatgtggaa caaacacgtt ataagaagtc tggccttcat      540

tttcgacaca cagataatac cgtccagtgg ttaagagcga tggagtctat tggtctaccc      600

aagatatttt atccagaaac aacagatgtc tatgatcgga aaaacatacc aagaatgata      660

tattgcattc acgcactgag tttgtatctg ttcaaactag gaatagcacc ccagatccag      720

gatttgttgg gcaaagtaga cttcacagag gaggaaatca gtaatatgag aaaagaactt      780

gagaaatatg gaatacagat gccatctttc agcaaaatag gtggtattct ggccaatgaa      840

ctgtccgtgg atgaagctgc attacatgct gcagttatag ccattaatga agcagttgaa      900

aaaggaatag cagagcaaac cgttgtaaca ctaagaaacc caaatgcggt tttaacttta      960

gtggatgaca accttgcacc agaatatcag aaagaactct gggatgccaa aaagaaaaaa     1020

gaggaaaatg caagactgaa gaatagctgt atttcagaag aagaaagaga tgcttatgaa     1080

gaactgctga cacaagcaga aatccaaggc aatattaata aagtcaacag gcaggctgca     1140

gtggaccata tcaatgctgt cattccggaa ggtgaccccg agaatacgct gcttgcactg     1200

aagaaaccag aggcccagct gcctgctgtt tatccctttg ctgctgccat gtatcagaac     1260

gaacttttca acctccagaa acagaacacc atgaactact tggcccacga ggagcttttg     1320

attgctgtgg aaatgttgtc tgctgttgct ttactaaacc aggccttgga aagcaacgat     1380

cttgtgtctg tgcagaatca actcagaagc cccgcaatag gcttaaacaa tctggacaag     1440

gcatatgtgg aacgttatgc aaacacacta ctctctgtta aactagaagt tttatcccaa     1500

gggcaagata acttaagctg gaatgaaatt cagaattgta ttgatatggt taatgctcaa     1560

attcaagaag aaaatgaccg agttgtagct gtagggtaca tcaatgaagc tattgatgaa     1620

gggaatcctt tgaggacttt agaaactttg ctcctaccta ctgcgaatat tagtgatgtg     1680

gacccagccc atgcccagca ctaccaggat gttttatacc atgctaaatc acagaaactc     1740

ggagactctg agagtgtttc caaagtgctt tggctggatg agatacagca agccgtcgat     1800

gatgccaacg tggacgagga cagagcaaaa caatgggtta ctctggtggt tgatgttaat     1860

cagtgtttgg aaggaaaaaa atcaagtgat attttgtctg tattgaagtc ttccacttct     1920

aatgcaaatg acataatccc ggagtgtgct gacaaatact atgatgccct tgtgaaggca     1980

aaagagctca aatctgaaag agtgtctagt gacggttcat ggctcaaact caacctgcac     2040

aaaaaatatg actactatta caacactgat tcaaaagaga gttcctgggt cacacctgaa     2100

tcatgcttgt ataaagaatc atggctcaca ggaaaagaaa tcgaggacat tattgaggaa     2160

gtcacagtag gttacattcg tgagaatata tggtctgctt cagaagagtt gcttcttcgc     2220

tttcaagcca caagctcagg acccatcctt agggaagagt ttgaagctag aaaatcattt     2280

ttgcatgaac aagaagagaa tgtggtcaaa atacaggctt tttggaaagg atataaacaa     2340

cggaaggagt atatgcacag gcggcaaacg ttcattgata atactgattc tattgtgaag     2400

attcagtcct ggttccgaat ggcaactgca agaaagagct atctttcaag actacagtat     2460

ttcagagatc ataataatga aattgtgaaa atacagtcac tgttgagagc gaacaaagct     2520

agagatgact acaaaacatt ggttggctct gaaaacccac cattaacagt aattcgcaaa     2580

tttgtatacc tgctggacca aagtgatttg gatttccagg aggaactaga ggttgcacga     2640

ttaagggaag aagtagtgac caagatcagg gccaatcaac agctggaaaa agacctgaac     2700

ctgatggaca tcaagattgg actgctggtg aagaacagga tcacactaga ggatgtaatt     2760

tcacacagta aaaagctgaa caagaaaaaa ggaggagaaa tggaaatact gaataacacc     2820

gacaaccaag gaataaaaag tttgagtaag gagaggagaa aaacactaga aacatatcag     2880

cagctgtttt accttttaca gaccaaccct ttatacttgg ctaagctgat tttccagatg     2940

ccacagaaca agtccactaa atttatggat actgttattt tcacactata taattatgcc     3000

tctaatcagc gagaagaata tctacttctc aagcttttta aaactgctct ggaggaagaa     3060

ataaaatcaa aagtggacca ggtacaggac atagttactg gtaaccctac agtcatcaag     3120

atggtcgtca gcttcaatag aggtgcccgg ggacagaaca ccctgcgcca actcctggct     3180

ccagtggtaa aagagatcat cgacgacaag tcgctgatta tcaacacaaa ccctgtagag     3240

gtgtacaagg cttgggtgaa ccaactagaa acacagactg gagaggccag caagttgcct     3300

tatgatgtga ccacagaaca agctctaaca tacccagaag tgaaaaataa actggaggct     3360

tccattgaga acctgagaag ggtcaccgac aaagtcctga attctatcat ttcttccctt     3420

gatctactgc cttatggatt gaggtatata gccaaagtac tgaagaattc gatccatgag     3480

aaattccccg atgcaacaga agatgagcta ttaaagattg ttggaaacct cctgtactat     3540

cggtacatga atccagccat tgtagctcca gatggctttg atatcatcga catgacagct     3600

ggaggtcaga taaattctga ccaaaggaga aacttaggat cagtggccaa ggttcttcag     3660

cacgcagcct ccaacaagct gtttgaagga gaaaatgagc atctctcatc tatgaacaat     3720

tatttatcag agacgtatca ggaattcagg aaatatttca aagaagcatg taatgtccct     3780

gagccagaag agaagtttaa tatggacaaa tacacagacc tggtgacagt cagcaaacca     3840

gtcatttata tttcaattga agaaatcatc agcacacact cactcctgtt ggaacaccag     3900

gatgcaattg cccctgagaa aaatgactta ctgagtgaat tgctggggtc gctgggagag     3960

gtgccaaccg tggaatcttt tcttggggaa ggagcagttg accccaatga ccctaacaag     4020

gcaaatacac taagtcagct ttcaaagacc gagatttctc ttgtcttgac aagcaaatat     4080

gacatagagg acggtgaagc tatagatagc cgaagcctca tgataaagac caagaagctg     4140

ataattgatg tgatccggaa ccagccaggg aacacattga cagaaatctt agagacacca     4200

gcaactgcgc aacaggaggt agaccatgcc acggacatgg tgagccgtgc aatgatagat     4260

tccaggactc cagaagaaat gaagcatagc caatctatga ttgaagatgc acagctgcct     4320

cttgagcaga agaagaggaa aatccagagg aatcttcgga cgttggaaca gactggacac     4380

gtgtcatccg aaaataaata ccaagacatt ctcaatgaga ttgccaagga tattcgaaat     4440

caaagaatct atcgtaagct tcgaaaagct gaattggcaa aacttcagca gaccctgaat     4500

gcacttaaca agaaggcagc attttatgaa gagcaaatca attattatga cacctacata     4560

aagacttgtt tagacaactt aaaaagaaaa aatactcgga gatcaattaa actagatgga     4620

aaaggagaac ccaaaggggc gaagagagcg aagccagtga agtacactgc agcaaagctg     4680

catgagaaag gtgtcctgct agatatagat gatcttcaaa caaaccagtt taagaatgtt     4740

acatttgata tcatagctac tgaagatgta ggcattttcg atgtaagatc aaaattcctt     4800

ggtgttgaga tggaaaaggt gcaactcaat attcaggatt tacttcagat gcaatatgaa     4860

ggagtagctg taatgaaaat gtttgataag gttaaagtga atgtaaacct tctcatatac     4920

ctgctgaaca agaagttcta tggaaagtga agtgcctaca gaaatttctt ggattctgta     4980

tcatctggat taggaaatga atttgtttaa tatttttgtt tttaaacatg attgaaatca     5040

ctgcttataa atgtgtgatt tttttaaaac gaccaaaact gttctgaaga atgtacccag     5100

gtgccttttt gctaatttga tactataata gaatgagaca taaaatgaat taatggaaac     5160

atatccacac tgtactgtga tataggtact ctgatttaaa actttggaca tcctgtgatc     5220

tgttttaaag ttggggggtg ggaaatttag ctgactaggg acaaacatgt aaacctattt     5280

tcctatgaaa aaaattttaa atgtcccact tgaataacgt aattcttcat agttttttta     5340

atctatggat aaatggaaac ctaattattt gtaatgaatt atttagacag ttctaagccc     5400

tgtcttctgg gagttatcaa ttttaaagag aacttttgtg caattcaaat gaagttttta     5460

taagtaattg aaaatgacaa cacaataaca ctttctgtat aaaagtatat attttatgtg     5520

atttattcct actaaatgaa agtgcactac tgcctcatgt aaagactctt gcacgcagag     5580

cctttaagtg actaaggaac aacatagata gtgagcatag tccccacctc cacccctcac     5640

aatttatttg aatacttcaa ttgtgcctct caattttttg taatgctaaa aaatcagtat     5700

ctagatggtt tttaaatgta ttctctggaa attgttttat gtaaaataaa tgttacttaa     5760

ttccattaa                                                             5769


<210>  2
<211>  979
<212>  DNA
<213>  Homo sapiens

<400>  2
ttataaaagt gttcatttta atgagataac tgtcatatta aagccttaat atttcagggt       60

gacaagaaag tctggaaaca taggcaaata ttttccattt tgacagtgtt aagtgaccaa      120

cttgaatgcc agcacttgat gagtggaggg aaagtaaccg ggagtgattc caacaagatg      180

gcacaccacc cccttacacc acattggtga agaaagctgg atgaagattt ccaaagaaag      240

cggccctgtg gagtgggctt caggcttgcc agatctggac tcccttgata gcttcttctg      300

gagtgcactt aaaacacaga tttattccgt gaaaatcaag cagcatcaca gatgcacatg      360

cagggactga cagaaatgct gcattcatgt accacattca cggaaatttt gcactattta      420

ttgctcatga gggccgacat caatcatgtg atagcaagaa atcatttgtt catgtagatt      480

cacctagttt gcagaagttt gtggttatct tatcatttga cacagtgaag ccaccatata      540

ttctgagagc tggtcacatt aaagtacttc caccaacctg aggttggcac tgcaaacact      600

gaatgagcac agcattcctc cttgaaccca acgggctctg ctgtatctgt ggtttaccaa      660

aaggcaaaaa gctgggtccc acctgaggtt ggcactgcaa acactgaatg agcacagcgt      720

tccctcttga acccaagagg ctctgctgtc tgtgtggttt accaaaaggc aaaaagctgg      780

gtctcagtca actgctgaat gcattagagt acagaggctg tagtcctcag gcctccccct      840

cactgcaagg gtaacacagg aaagataacc tcccatcttt gacacgccag cggggaggag      900

gggaaagaac ctacacaagt tgaggagccc tttttcagtt aagcaagtca gtggccttac      960

gcaccatcca aaaccacac                                                   979


<210>  3
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  3
actttccctc cactcatca                                                    19


<210>  4
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide


<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  n is a, c, g, or t

<400>  4
tcctcccngc tgcgtgtcaa a                                                 21


<210>  5
<211>  19
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  5
agcatttctg tcagtccct                                                    19


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  6
accacagata cagcagagcc c                                                 21


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  7
accacacaga cagcagagcc t                                                 21


