                         SEQUENCE LISTING

<110>  DSM IP Assets B.V.
       Raemakers-Franken, Petronella Catharina
       Trefzer, Axel Christoph
       Vermote, Linda
 
<120>  Preparation of alpha-ketopimelic acid

<130>  P88811PC00

<150>  EP 09170078.1
<151>  2009-09-11

<160>  210   

<170>  PatentIn version 3.3

<210>  1
<211>  1362
<212>  DNA
<213>  Vibrio fluvialis


<220>
<221>  CDS
<222>  (1)..(1362)

<400>  1
atg aac aaa ccg caa agc tgg gaa gcc cgg gcc gag acc tat tcg ctc       48
Met Asn Lys Pro Gln Ser Trp Glu Ala Arg Ala Glu Thr Tyr Ser Leu         
1               5                   10                  15              

tat ggt ttc acc gac atg cct tcg ctg cat cag cgc ggc acg gtc gtc       96
Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val         
            20                  25                  30                  

gtg acc cat ggc gag gga ccc tat atc gtc gat gtg aat ggc cgg cgt      144
Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val Asn Gly Arg Arg         
        35                  40                  45                      

tat ctg gac gcc aac tcg ggc ctg tgg aac atg gtc gcg ggc ttt gac      192
Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val Ala Gly Phe Asp         
    50                  55                  60                          

cac aag ggg ctg atc gac gcc gcc aag gcc caa tac gag cgt ttt ccc      240
His Lys Gly Leu Ile Asp Ala Ala Lys Ala Gln Tyr Glu Arg Phe Pro         
65                  70                  75                  80          

ggt tat cac gcc ttt ttc ggc cgc atg tcc gat cag acg gta atg ctg      288
Gly Tyr His Ala Phe Phe Gly Arg Met Ser Asp Gln Thr Val Met Leu         
                85                  90                  95              

tcg gaa aag ctg gtc gag gtg tcg ccc ttt gat tcg ggc cgg gtg ttc      336
Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe         
            100                 105                 110                 

tat aca aac tcg ggg tcc gag gcg aat gac acc atg gtc aag atg cta      384
Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu         
        115                 120                 125                     

tgg ttc ctg cat gca gcc gag ggc aaa ccg caa aag cgc aag atc ctg      432
Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu         
    130                 135                 140                         

acc cgc tgg aac gcc tat cac ggc gtg acc gcc gtt tcg gcc agc atg      480
Thr Arg Trp Asn Ala Tyr His Gly Val Thr Ala Val Ser Ala Ser Met         
145                 150                 155                 160         

acc ggc aag ccc tat aat tcg gtc ttt ggc ctg ccg ctg ccg ggc ttt      528
Thr Gly Lys Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe         
                165                 170                 175             

gtg cat ctg acc tgc ccg cat tac tgg cgc tat ggc gaa gag ggc gaa      576
Val His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu         
            180                 185                 190                 

acc gaa gag cag ttc gtc gcc cgc ctc gcc cgc gag ctg gag gaa acg      624
Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr         
        195                 200                 205                     

atc cag cgc gag ggc gcc gac acc atc gcc ggt ttc ttt gcc gaa ccg      672
Ile Gln Arg Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro         
    210                 215                 220                         

gtg atg ggc gcg ggc ggc gtg att ccc ccg gcc aag ggc tat ttc cag      720
Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln         
225                 230                 235                 240         

gcg atc ctg cca atc ctg cgc aaa tat gac atc ccg gtc atc tcg gac      768
Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp         
                245                 250                 255             

gag gtg atc tgc ggt ttc gga cgc acc ggt aac acc tgg ggc tgc gtg      816
Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val         
            260                 265                 270                 

acc tat gac ttt aca ccc gat gca atc atc tcg tcc aag aat ctt aca      864
Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Asn Leu Thr         
        275                 280                 285                     

gcg ggc ttt ttc ccc atg ggg gcg gtg atc ctt ggc ccg gaa ctt tcc      912
Ala Gly Phe Phe Pro Met Gly Ala Val Ile Leu Gly Pro Glu Leu Ser         
    290                 295                 300                         

aaa cgg ctg gaa acc gca atc gag gcg atc gag gaa ttc ccc cat ggc      960
Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro His Gly         
305                 310                 315                 320         

ttt acc gcc tcg ggc cat ccg gtc ggc tgt gct att gcg ctg aaa gca     1008
Phe Thr Ala Ser Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala         
                325                 330                 335             

atc gac gtg gtg atg aat gaa ggg ctg gct gag aac gtc cgc cgc ctt     1056
Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu         
            340                 345                 350                 

gcc ccc cgt ttc gag gaa agg ctg aaa cat atc gcc gag cgc ccg aac     1104
Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn         
        355                 360                 365                     

atc ggt gaa tat cgc ggc atc ggc ttc atg tgg gcg ctg gag gct gtc     1152
Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Ala Val         
    370                 375                 380                         

aag gac aag gca agc aag acg ccg ttc gac ggc aac ctg tcg gtc agc     1200
Lys Asp Lys Ala Ser Lys Thr Pro Phe Asp Gly Asn Leu Ser Val Ser         
385                 390                 395                 400         

gag cgt atc gcc aat acc tgc acc gat ctg ggg ctg att tgc cgg ccg     1248
Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro         
                405                 410                 415             

ctt ggt cag tcc gtc gtc ctt tgt ccg ccc ttt atc ctg acc gag gcg     1296
Leu Gly Gln Ser Val Val Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala         
            420                 425                 430                 

cag atg gat gag atg ttc gat aaa ctc gaa aaa gcc ctt gat aag gtc     1344
Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val         
        435                 440                 445                     

ttt gcc gag gtt gcc tga                                             1362
Phe Ala Glu Val Ala                                                     
    450                                                                 


<210>  2
<211>  453
<212>  PRT
<213>  Vibrio fluvialis

<400>  2

Met Asn Lys Pro Gln Ser Trp Glu Ala Arg Ala Glu Thr Tyr Ser Leu 
1               5                   10                  15      


Tyr Gly Phe Thr Asp Met Pro Ser Leu His Gln Arg Gly Thr Val Val 
            20                  25                  30          


Val Thr His Gly Glu Gly Pro Tyr Ile Val Asp Val Asn Gly Arg Arg 
        35                  40                  45              


Tyr Leu Asp Ala Asn Ser Gly Leu Trp Asn Met Val Ala Gly Phe Asp 
    50                  55                  60                  


His Lys Gly Leu Ile Asp Ala Ala Lys Ala Gln Tyr Glu Arg Phe Pro 
65                  70                  75                  80  


Gly Tyr His Ala Phe Phe Gly Arg Met Ser Asp Gln Thr Val Met Leu 
                85                  90                  95      


Ser Glu Lys Leu Val Glu Val Ser Pro Phe Asp Ser Gly Arg Val Phe 
            100                 105                 110         


Tyr Thr Asn Ser Gly Ser Glu Ala Asn Asp Thr Met Val Lys Met Leu 
        115                 120                 125             


Trp Phe Leu His Ala Ala Glu Gly Lys Pro Gln Lys Arg Lys Ile Leu 
    130                 135                 140                 


Thr Arg Trp Asn Ala Tyr His Gly Val Thr Ala Val Ser Ala Ser Met 
145                 150                 155                 160 


Thr Gly Lys Pro Tyr Asn Ser Val Phe Gly Leu Pro Leu Pro Gly Phe 
                165                 170                 175     


Val His Leu Thr Cys Pro His Tyr Trp Arg Tyr Gly Glu Glu Gly Glu 
            180                 185                 190         


Thr Glu Glu Gln Phe Val Ala Arg Leu Ala Arg Glu Leu Glu Glu Thr 
        195                 200                 205             


Ile Gln Arg Glu Gly Ala Asp Thr Ile Ala Gly Phe Phe Ala Glu Pro 
    210                 215                 220                 


Val Met Gly Ala Gly Gly Val Ile Pro Pro Ala Lys Gly Tyr Phe Gln 
225                 230                 235                 240 


Ala Ile Leu Pro Ile Leu Arg Lys Tyr Asp Ile Pro Val Ile Ser Asp 
                245                 250                 255     


Glu Val Ile Cys Gly Phe Gly Arg Thr Gly Asn Thr Trp Gly Cys Val 
            260                 265                 270         


Thr Tyr Asp Phe Thr Pro Asp Ala Ile Ile Ser Ser Lys Asn Leu Thr 
        275                 280                 285             


Ala Gly Phe Phe Pro Met Gly Ala Val Ile Leu Gly Pro Glu Leu Ser 
    290                 295                 300                 


Lys Arg Leu Glu Thr Ala Ile Glu Ala Ile Glu Glu Phe Pro His Gly 
305                 310                 315                 320 


Phe Thr Ala Ser Gly His Pro Val Gly Cys Ala Ile Ala Leu Lys Ala 
                325                 330                 335     


Ile Asp Val Val Met Asn Glu Gly Leu Ala Glu Asn Val Arg Arg Leu 
            340                 345                 350         


Ala Pro Arg Phe Glu Glu Arg Leu Lys His Ile Ala Glu Arg Pro Asn 
        355                 360                 365             


Ile Gly Glu Tyr Arg Gly Ile Gly Phe Met Trp Ala Leu Glu Ala Val 
    370                 375                 380                 


Lys Asp Lys Ala Ser Lys Thr Pro Phe Asp Gly Asn Leu Ser Val Ser 
385                 390                 395                 400 


Glu Arg Ile Ala Asn Thr Cys Thr Asp Leu Gly Leu Ile Cys Arg Pro 
                405                 410                 415     


Leu Gly Gln Ser Val Val Leu Cys Pro Pro Phe Ile Leu Thr Glu Ala 
            420                 425                 430         


Gln Met Asp Glu Met Phe Asp Lys Leu Glu Lys Ala Leu Asp Lys Val 
        435                 440                 445             


Phe Ala Glu Val Ala 
    450             


<210>  3
<211>  1362
<212>  DNA
<213>  Artificial

<220>
<223>  Vibrio fluvialis JS17 omega-aminotransferase codon optimised gene

<400>  3
atgaataaac cacagtcttg ggaagctcgt gctgaaacct atagcctgta cggctttacc     60

gatatgccgt ctctgcacca gcgtggtact gtagtggtaa cgcacggtga gggcccgtac    120

atcgtggacg ttaatggccg ccgttacctg gatgcaaaca gcggcctgtg gaacatggtt    180

gcgggcttcg accacaaagg cctgatcgat gccgcaaaag cgcagtacga acgcttcccg    240

ggttatcacg cgttctttgg ccgtatgagc gaccagactg tgatgctgag cgaaaaactg    300

gttgaagtgt ccccgttcga tagcggtcgt gtcttttaca ctaactctgg cagcgaggct    360

aacgatacca tggttaagat gctgtggttc ctgcacgcag cggaaggcaa acctcagaaa    420

cgtaaaattc tgacccgttg gaacgcttat cacggtgtga ctgctgtttc cgcatctatg    480

accggtaaac cgtataacag cgtgttcggt ctgccgctgc ctggcttcgt gcatctgacc    540

tgcccgcact actggcgtta tggtgaggaa ggcgaaactg aggaacagtt cgtggcgcgt    600

ctggctcgtg aactggaaga aaccattcaa cgcgaaggtg cagatactat cgcgggcttc    660

tttgcggagc ctgttatggg tgccggcggt gtgattccgc cggcgaaggg ctatttccag    720

gcaatcctgc cgatcctgcg caagtacgac attccggtta tttctgacga agtgatctgc    780

ggcttcggcc gcaccggtaa cacctggggc tgcgtgacgt atgacttcac tccggacgca    840

atcattagct ctaaaaacct gactgcgggt ttcttcccta tgggcgccgt aatcctgggc    900

ccagaactgt ctaagcgcct ggaaaccgcc atcgaggcaa tcgaagagtt cccgcacggt    960

ttcactgcta gcggccatcc ggtaggctgc gcaatcgcgc tgaaggcgat cgatgttgtc   1020

atgaacgagg gcctggcgga aaacgtgcgc cgcctggcgc cgcgttttga agaacgtctg   1080

aaacacattg ctgagcgccc gaacattggc gaatatcgcg gcatcggttt catgtgggcc   1140

ctggaagcag ttaaagataa agctagcaag accccgttcg acggcaacct gtccgtgagc   1200

gaacgtatcg ctaatacctg tacggacctg ggtctgatct gccgtccgct gggtcagtcc   1260

gtagttctgt gcccaccatt tatcctgacc gaagcgcaga tggatgaaat gttcgataaa   1320

ctggagaaag ctctggataa agtgttcgct gaagtcgcgt aa                      1362


<210>  4
<211>  406
<212>  PRT
<213>  Methanococcus jannaschii

<400>  4

Met Thr Lys Val Leu Val Met Phe Met Asp Phe Leu Phe Glu Asn Ser 
1               5                   10                  15      


Trp Lys Ala Val Cys Pro Tyr Asn Pro Lys Leu Asp Leu Lys Asp Ile 
            20                  25                  30          


Tyr Ile Tyr Asp Thr Thr Leu Arg Asp Gly Glu Gln Thr Pro Gly Val 
        35                  40                  45              


Cys Phe Thr Lys Glu Gln Lys Leu Glu Ile Ala Arg Lys Leu Asp Glu 
    50                  55                  60                  


Leu Gly Leu Lys Gln Ile Glu Ala Gly Phe Pro Ile Val Ser Glu Arg 
65                  70                  75                  80  


Glu Ala Asp Ile Val Lys Thr Ile Ala Asn Glu Gly Leu Asn Ala Asp 
                85                  90                  95      


Ile Leu Ala Leu Cys Arg Ala Leu Lys Lys Asp Ile Asp Lys Ala Ile 
            100                 105                 110         


Glu Cys Asp Val Asp Gly Ile Ile Thr Phe Ile Ala Thr Ser Pro Leu 
        115                 120                 125             


His Leu Lys Tyr Lys Phe Asn Asn Lys Ser Leu Asp Glu Ile Leu Glu 
    130                 135                 140                 


Met Gly Val Glu Ala Val Glu Tyr Ala Lys Glu His Gly Leu Phe Val 
145                 150                 155                 160 


Ala Phe Ser Ala Glu Asp Ala Thr Arg Thr Pro Ile Glu Asp Leu Ile 
                165                 170                 175     


Lys Val His Lys Ala Ala Glu Glu Ala Gly Ala Asp Arg Val His Ile 
            180                 185                 190         


Ala Asp Thr Thr Gly Cys Ala Thr Pro Gln Ser Met Glu Phe Ile Cys 
        195                 200                 205             


Lys Thr Leu Lys Glu Asn Leu Lys Lys Ala His Ile Gly Val His Cys 
    210                 215                 220                 


His Asn Asp Phe Gly Phe Ala Val Ile Asn Ser Ile Tyr Gly Leu Ile 
225                 230                 235                 240 


Gly Gly Ala Lys Ala Val Ser Thr Thr Val Asn Gly Ile Gly Glu Arg 
                245                 250                 255     


Ala Gly Asn Ala Ala Leu Glu Glu Leu Ile Met Ala Leu Thr Val Leu 
            260                 265                 270         


Tyr Asp Val Asp Leu Gly Leu Asn Leu Glu Val Leu Pro Glu Leu Cys 
        275                 280                 285             


Arg Met Val Glu Glu Tyr Ser Gly Ile Lys Met Pro Lys Asn Lys Pro 
    290                 295                 300                 


Ile Val Gly Glu Leu Val Phe Ala His Glu Ser Gly Ile His Val Asp 
305                 310                 315                 320 


Ala Val Ile Glu Asn Pro Leu Thr Tyr Glu Pro Phe Leu Pro Glu Lys 
                325                 330                 335     


Ile Gly Leu Lys Arg Asn Ile Leu Leu Gly Lys His Ser Gly Cys Arg 
            340                 345                 350         


Ala Val Ala Tyr Lys Leu Lys Leu Met Gly Ile Asp Tyr Asp Arg Glu 
        355                 360                 365             


Met Leu Cys Glu Ile Val Lys Lys Val Lys Glu Ile Arg Glu Glu Gly 
    370                 375                 380                 


Lys Phe Ile Thr Asp Glu Val Phe Lys Glu Ile Val Glu Glu Val Leu 
385                 390                 395                 400 


Arg Lys Arg Asn Lys Asn 
                405     


<210>  5
<211>  391
<212>  PRT
<213>  Methanothermobacter thermautotrophicus

<400>  5

Met Arg Tyr Phe Val Ser Pro Phe Asn Lys Glu Ala Glu Leu Lys Phe 
1               5                   10                  15      


Pro Asp Arg Ile Thr Ile Tyr Asp Thr Thr Leu Arg Asp Gly Glu Gln 
            20                  25                  30          


Thr Pro Gly Val Cys Leu Gly Thr Glu Glu Lys Leu Glu Ile Ala Arg 
        35                  40                  45              


Lys Leu Asp Glu Leu Gly Ile His Gln Ile Glu Ser Gly Phe Pro Val 
    50                  55                  60                  


Val Ser Glu Gln Glu Arg Val Ser Val Lys Ser Ile Ala Asn Glu Gly 
65                  70                  75                  80  


Leu Asn Ala Glu Ile Leu Ala Leu Cys Arg Thr Lys Lys Asp Asp Ile 
                85                  90                  95      


Asp Ala Ala Ile Asp Cys Asp Val Asp Gly Val Ile Thr Phe Met Ala 
            100                 105                 110         


Thr Ser Asp Leu His Leu Lys His Lys Leu Lys Leu Thr Arg Glu Glu 
        115                 120                 125             


Ala Leu Asn Val Cys Met Asn Ser Ile Glu Tyr Ala Lys Asp His Gly 
    130                 135                 140                 


Leu Phe Leu Ala Phe Ser Ala Glu Asp Ala Thr Arg Thr Asp Leu Asp 
145                 150                 155                 160 


Phe Leu Lys Gln Ile Tyr Arg Lys Ala Glu Asn Tyr Gly Ala Asp Arg 
                165                 170                 175     


Val His Ile Ala Asp Thr Val Gly Ala Ile Ser Pro Gln Gly Met Asp 
            180                 185                 190         


Tyr Leu Val Arg Glu Leu Arg Arg Asp Ile Lys Val Asp Ile Ala Leu 
        195                 200                 205             


His Cys His Asn Asp Phe Gly Met Ala Leu Ser Asn Ser Ile Ala Gly 
    210                 215                 220                 


Leu Leu Ala Gly Gly Thr Ala Val Ser Thr Thr Val Asn Gly Ile Gly 
225                 230                 235                 240 


Glu Arg Ala Gly Asn Thr Ser Leu Glu Glu Leu Ile Met Ala Leu Arg 
                245                 250                 255     


Ile Ile Tyr Glu Val Asp Leu Gly Phe Asn Ile Gly Val Leu Tyr Glu 
            260                 265                 270         


Leu Ser Arg Leu Val Glu Lys His Thr Arg Met Lys Val Pro Glu Asn 
        275                 280                 285             


Lys Pro Ile Val Gly Arg Asn Val Phe Arg His Glu Ser Gly Ile His 
    290                 295                 300                 


Val Asp Ala Val Ile Glu Glu Pro Leu Thr Tyr Glu Pro Phe Leu Pro 
305                 310                 315                 320 


Glu Met Ile Gly His Gln Arg Lys Ile Val Leu Gly Lys His Ser Gly 
                325                 330                 335     


Cys Arg Ala Val Lys Ala Lys Leu Glu Glu Tyr Gly Ile Asp Val Thr 
            340                 345                 350         


Arg Asp Glu Leu Cys Arg Ile Val Glu Glu Val Lys Lys Asn Arg Glu 
        355                 360                 365             


Lys Gly Lys Tyr Ile Asn Asp Glu Leu Phe Tyr Arg Ile Val Lys Ser 
    370                 375                 380                 


Val Arg Gly Pro Val Asp Phe 
385                 390     


<210>  6
<211>  386
<212>  PRT
<213>  Methanococcus maripaludis

<400>  6

Met Asp Trp Lys Ala Val Ser Pro Tyr Asn Pro Lys Leu Asp Leu Lys 
1               5                   10                  15      


Asp Cys Tyr Leu Tyr Asp Thr Thr Leu Arg Asp Gly Glu Gln Thr Pro 
            20                  25                  30          


Gly Val Cys Phe Ala Gly Asp Gln Lys Leu Glu Ile Ala Lys Lys Leu 
        35                  40                  45              


Asp Glu Leu Lys Ile Lys Gln Ile Glu Ala Gly Phe Pro Ile Val Ser 
    50                  55                  60                  


Glu Asn Glu Arg Lys Ala Ile Lys Ser Ile Thr Gly Glu Gly Leu Asn 
65                  70                  75                  80  


Ala Gln Ile Leu Ala Leu Ser Arg Val Leu Lys Glu Asp Ile Asp Lys 
                85                  90                  95      


Ala Ile Glu Cys Asp Val Asp Gly Ile Ile Thr Phe Ile Ala Thr Ser 
            100                 105                 110         


Pro Met His Leu Lys Tyr Lys Leu His Lys Asn Leu Asp Glu Val Glu 
        115                 120                 125             


Glu Met Gly Met Lys Ala Val Glu Tyr Ala Lys Asp His Gly Leu Phe 
    130                 135                 140                 


Val Ala Phe Ser Ala Glu Asp Ala Thr Arg Thr Pro Leu Glu Asp Ile 
145                 150                 155                 160 


Ile Arg Ile His Lys Asn Ala Glu Glu His Gly Ala Asp Arg Val His 
                165                 170                 175     


Ile Ala Asp Thr Leu Gly Cys Ala Thr Pro Gln Ala Met Tyr His Ile 
            180                 185                 190         


Cys Ser Glu Leu Ser Lys His Leu Lys Lys Ala His Ile Gly Val His 
        195                 200                 205             


Cys His Asn Asp Phe Gly Phe Ala Val Ile Asn Ser Ile Tyr Gly Leu 
    210                 215                 220                 


Ile Gly Gly Ala Lys Ala Val Ser Thr Thr Val Asn Gly Ile Gly Glu 
225                 230                 235                 240 


Arg Ala Gly Asn Ala Ala Ile Glu Glu Ile Ala Met Ala Leu Lys Val 
                245                 250                 255     


Leu Tyr Asp His Asp Met Gly Leu Asn Thr Glu Ile Leu Thr Glu Ile 
            260                 265                 270         


Ser Lys Leu Val Glu Asn Tyr Ser Lys Ile Lys Ile Pro Glu Asn Lys 
        275                 280                 285             


Pro Leu Val Gly Glu Met Val Phe Tyr His Glu Ser Gly Ile His Val 
    290                 295                 300                 


Asp Ala Val Leu Glu Asn Pro Leu Thr Tyr Glu Pro Phe Leu Pro Glu 
305                 310                 315                 320 


Lys Ile Gly Gln Lys Arg Lys Ile Ile Leu Gly Lys His Ser Gly Cys 
                325                 330                 335     


Arg Ala Val Ala His Arg Leu Gln Glu Leu Gly Leu Glu Ala Ser Arg 
            340                 345                 350         


Asp Glu Leu Trp Glu Ile Val Lys Lys Thr Lys Glu Thr Arg Glu Asp 
        355                 360                 365             


Gly Thr Glu Ile Ser Asp Glu Val Phe Lys Asn Ile Ala Glu Lys Ile 
    370                 375                 380                 


Ile Lys 
385     


<210>  7
<211>  386
<212>  PRT
<213>  Methanococcus maripaludis

<400>  7

Met Asp Trp Lys Ala Val Ser Pro Tyr Asn Pro Lys Leu Asn Leu Lys 
1               5                   10                  15      


Asp Cys Tyr Leu Tyr Asp Thr Thr Leu Arg Asp Gly Glu Gln Thr Pro 
            20                  25                  30          


Gly Val Cys Phe Thr His Asp Gln Lys Leu Glu Ile Ala Lys Lys Leu 
        35                  40                  45              


Asp Glu Leu Lys Ile Lys Gln Ile Glu Ala Gly Phe Pro Ile Val Ser 
    50                  55                  60                  


Glu Asn Glu Arg Lys Ala Ile Lys Ser Ile Thr Gly Glu Gly Leu Asn 
65                  70                  75                  80  


Ala Gln Ile Leu Ala Leu Ser Arg Val Leu Lys Glu Asp Ile Asp Lys 
                85                  90                  95      


Ala Ile Glu Cys Asp Val Asp Gly Ile Ile Thr Phe Ile Ala Ala Ser 
            100                 105                 110         


Pro Met His Leu Lys Tyr Lys Leu His Lys Ser Leu Asp Glu Val Glu 
        115                 120                 125             


Glu Met Gly Met Lys Ala Val Glu Tyr Ala Lys Asp His Gly Leu Phe 
    130                 135                 140                 


Val Ala Phe Ser Ala Glu Asp Ala Thr Arg Thr Pro Val Glu Asp Leu 
145                 150                 155                 160 


Ile Arg Ile His Lys Asn Ala Glu Glu His Gly Ala Asn Arg Val His 
                165                 170                 175     


Ile Ala Asp Thr Leu Gly Cys Ala Thr Pro Gln Ala Met Tyr His Ile 
            180                 185                 190         


Cys Ser Glu Leu Ser Ser Asn Leu Lys Lys Ala His Ile Gly Val His 
        195                 200                 205             


Cys His Asn Asp Phe Gly Phe Ala Val Ile Asn Ser Ile Tyr Gly Leu 
    210                 215                 220                 


Ile Gly Gly Ala Lys Ala Val Ser Thr Thr Val Asn Gly Ile Gly Glu 
225                 230                 235                 240 


Arg Ala Gly Asn Ala Ala Ile Glu Glu Ile Val Met Ala Leu Lys Val 
                245                 250                 255     


Leu Tyr Asp His Asp Met Gly Leu Asn Thr Glu Ile Leu Thr Glu Ile 
            260                 265                 270         


Ser Lys Leu Val Glu Asn Tyr Ser Lys Ile Arg Ile Pro Glu Asn Lys 
        275                 280                 285             


Pro Leu Val Gly Glu Met Ala Phe Tyr His Glu Ser Gly Ile His Val 
    290                 295                 300                 


Asp Ala Val Leu Glu Asn Pro Leu Thr Tyr Glu Pro Phe Leu Pro Glu 
305                 310                 315                 320 


Lys Ile Gly Gln Lys Arg Lys Ile Ile Leu Gly Lys His Ser Gly Cys 
                325                 330                 335     


Arg Ala Val Ala His Arg Leu Gln Glu Leu Gly Leu Glu Ala Ser Arg 
            340                 345                 350         


Glu Glu Leu Trp Glu Ile Val Lys Lys Thr Lys Glu Thr Arg Glu Glu 
        355                 360                 365             


Gly Thr Glu Ile Ser Asp Glu Val Phe Lys Asn Ile Val Asp Lys Ile 
    370                 375                 380                 


Ile Lys 
385     


<210>  8
<211>  386
<212>  PRT
<213>  Methanococcus maripaludis

<400>  8

Met Asp Trp Lys Ala Val Ser Pro Tyr Asn Pro Lys Leu Asp Leu Lys 
1               5                   10                  15      


Asp Cys Tyr Leu Tyr Asp Thr Thr Leu Arg Asp Gly Glu Gln Thr Pro 
            20                  25                  30          


Gly Val Cys Phe Thr His Asp Gln Lys Leu Glu Ile Ala Lys Lys Leu 
        35                  40                  45              


Asp Glu Leu Lys Ile Lys Gln Ile Glu Ala Gly Phe Pro Ile Val Ser 
    50                  55                  60                  


Glu Asn Glu Arg Lys Cys Ile Lys Ser Ile Thr Gly Glu Gly Leu Asn 
65                  70                  75                  80  


Ala Gln Ile Leu Ala Leu Ser Arg Val Leu Lys Glu Asp Ile Asp Lys 
                85                  90                  95      


Ala Ile Glu Cys Asp Val Asp Gly Ile Ile Thr Phe Ile Ala Ala Ser 
            100                 105                 110         


Pro Met His Leu Lys Tyr Lys Leu His Lys Ser Leu Asp Glu Val Glu 
        115                 120                 125             


Glu Met Gly Met Lys Ala Val Glu Tyr Ala Lys Asp His Gly Leu Phe 
    130                 135                 140                 


Val Ala Phe Ser Ala Glu Asp Ala Thr Arg Thr Pro Ile Glu Asp Ile 
145                 150                 155                 160 


Ile Arg Ile His Lys Asn Ala Glu Glu His Gly Ala Asp Arg Val His 
                165                 170                 175     


Ile Ala Asp Thr Leu Gly Cys Ala Thr Pro Gln Ser Met Tyr Tyr Ile 
            180                 185                 190         


Cys Ser Glu Leu Ser Lys His Leu Lys Lys Ala His Ile Gly Val His 
        195                 200                 205             


Cys His Asn Asp Phe Gly Phe Ala Val Ile Asn Ser Ile Tyr Gly Leu 
    210                 215                 220                 


Leu Gly Gly Ala Lys Ala Val Ser Thr Thr Val Asn Gly Ile Gly Glu 
225                 230                 235                 240 


Arg Ala Gly Asn Ala Ala Ile Glu Glu Ile Val Met Ala Leu Lys Val 
                245                 250                 255     


Leu Tyr Asp Tyr Asp Met Gly Leu Asn Thr Glu Ile Leu Thr Glu Met 
            260                 265                 270         


Ser Lys Leu Val Glu Lys Tyr Ser Lys Ile Arg Ile Pro Glu Asn Lys 
        275                 280                 285             


Pro Leu Val Gly Glu Met Ala Phe Tyr His Glu Ser Gly Ile His Val 
    290                 295                 300                 


Asp Ala Val Leu Glu Asn Pro Leu Thr Tyr Glu Pro Phe Leu Pro Glu 
305                 310                 315                 320 


Lys Ile Gly Gln Lys Arg Lys Ile Ile Leu Gly Lys His Ser Gly Cys 
                325                 330                 335     


Arg Ala Val Ala His Arg Leu Gln Glu Leu Gly Leu Glu Thr Ser Arg 
            340                 345                 350         


Asn Glu Leu Trp Glu Ile Val Lys Lys Thr Lys Glu Thr Arg Glu Glu 
        355                 360                 365             


Gly Thr Glu Ile Ser Asp Glu Val Phe Lys Asn Ile Val Asp Lys Ile 
    370                 375                 380                 


Ile Lys 
385     


<210>  9
<211>  279
<212>  PRT
<213>  Methanosphaera stadtmanae

<400>  9

Met Gly Leu Ser Asp Leu His Leu Glu Val Lys Ile Asn Lys Pro Arg 
1               5                   10                  15      


Asp Val Val Asn Gln Ile Cys Met Asp Ala Ile Asp Tyr Gly Lys Asp 
            20                  25                  30          


His Gly Leu Phe Val Ala Phe Ser Ala Glu Asp Ala Thr Arg Thr Glu 
        35                  40                  45              


Leu Pro Lys Leu Leu Asp Val Tyr Lys Gln Ala Gln Asp His Gly Ala 
    50                  55                  60                  


Asp Arg Ile His Ile Ala Asp Thr Thr Gly Ser Ile Asn Pro Tyr Ala 
65                  70                  75                  80  


Thr Gln Tyr Leu Val Lys Asn Ile Lys Lys Glu Ile Asp Thr Glu Ile 
                85                  90                  95      


Ala Leu His Cys His Asn Asp Phe Gly Phe Ala Val Ala Asn Ser Ile 
            100                 105                 110         


Ala Gly Leu Phe Glu Gly Ala Thr Ala Ile Ser Thr Thr Val Asn Gly 
        115                 120                 125             


Ile Gly Glu Arg Ala Gly Asn Ala Ser Leu Glu Glu Leu Ile Met Ser 
    130                 135                 140                 


Leu Lys Leu Leu Tyr Asn Lys Asp Leu Gly Phe Lys Thr Glu Val Ile 
145                 150                 155                 160 


Tyr Glu Leu Ser Gln Leu Val Ser Lys Tyr Ser Lys Ile Pro Ile Ser 
                165                 170                 175     


Asp Ser Lys Ala Ile Val Gly Asn Asn Val Phe Arg His Glu Ser Gly 
            180                 185                 190         


Ile His Val Asp Ala Ile Val Lys Asn Pro Leu Ala Tyr Glu Pro Phe 
        195                 200                 205             


Ile Pro Glu Met Ile Gly Thr Lys Arg Gln Ile Val Leu Gly Lys His 
    210                 215                 220                 


Ser Gly Lys Ser Ala Val Ile Glu Lys Leu Asp Thr Leu Asn Ile Lys 
225                 230                 235                 240 


Val Asp Asp Thr Gln Leu Ser Gln Ile Val Ser Leu Val Lys Gln Glu 
                245                 250                 255     


Arg Glu Arg Gly Glu Glu Ile Thr Asn Asn Lys Phe Asp Glu Ile Leu 
            260                 265                 270         


Glu Lys Val Asn Ile Lys Arg 
        275                 


<210>  10
<211>  397
<212>  PRT
<213>  Methanopyrus kandleri

<400>  10

Met Gln Ser Pro Tyr Val Arg Glu Ala Val Arg Glu Met Asp Leu Pro 
1               5                   10                  15      


Asp Glu Val Ile Val Tyr Asp Thr Thr Leu Arg Asp Gly Glu Gln Thr 
            20                  25                  30          


Pro Gly Val Ser Phe Thr Pro Glu Gln Lys Leu Glu Ile Ala His Leu 
        35                  40                  45              


Leu Asp Glu Leu Gly Val Gln Gln Ile Glu Ala Gly Phe Pro Val Val 
    50                  55                  60                  


Ser Glu Gly Glu Arg Asp Ala Val Arg Arg Ile Ala His Glu Gly Leu 
65                  70                  75                  80  


Asn Ala Asp Ile Leu Cys Leu Ala Arg Thr Leu Arg Gly Asp Val Asp 
                85                  90                  95      


Ala Ala Leu Asp Cys Asp Val Asp Gly Val Ile Thr Phe Ile Ala Thr 
            100                 105                 110         


Ser Glu Leu His Leu Lys His Lys Leu Arg Met Ser Arg Glu Glu Val 
        115                 120                 125             


Leu Glu Arg Ile Ala Asp Thr Val Glu Tyr Ala Lys Asp His Gly Leu 
    130                 135                 140                 


Trp Val Ala Phe Ser Ala Glu Asp Gly Thr Arg Thr Glu Phe Glu Phe 
145                 150                 155                 160 


Leu Glu Arg Val Tyr Arg Thr Ala Glu Glu Cys Gly Ala Asp Arg Val 
                165                 170                 175     


His Ala Thr Asp Thr Val Gly Val Met Ile Pro Ala Ala Met Arg Leu 
            180                 185                 190         


Phe Val Ala Lys Ile Arg Glu Val Val Asp Leu Pro Ile Gly Val His 
        195                 200                 205             


Cys His Asp Asp Phe Gly Met Ala Val Ala Asn Ser Leu Ala Ala Val 
    210                 215                 220                 


Glu Ala Gly Ala Gln Ala Ile Ser Thr Thr Val Asn Gly Ile Gly Glu 
225                 230                 235                 240 


Arg Ala Gly Asn Ala Ala Leu Glu Glu Val Ile Met Ala Leu Lys Glu 
                245                 250                 255     


Leu Tyr Gly Ile Asp Pro Gly Phe Asn Thr Glu Val Leu Ala Glu Leu 
            260                 265                 270         


Ser Arg Lys Val Ser Glu Tyr Ser Gly Ile Asp Val Pro Pro Asn Lys 
        275                 280                 285             


Ala Val Val Gly Glu Asn Ala Phe Arg His Glu Ser Gly Ile His Val 
    290                 295                 300                 


Ala Ala Val Leu Glu Glu Pro Arg Thr Tyr Glu Pro Ile Asp Pro Lys 
305                 310                 315                 320 


Glu Val Gly Met Asn Arg Lys Ile Val Leu Gly Lys His Thr Gly Arg 
                325                 330                 335     


Lys Ala Val Val Ala Lys Leu Glu Glu Leu Gly Val Glu Pro Glu Glu 
            340                 345                 350         


Glu Ile Val Glu Glu Val Leu Lys Arg Ile Lys Ala Leu Gly Asp Arg 
        355                 360                 365             


Arg Val Arg Val Thr Asp Ser Lys Leu Glu Glu Ile Val Arg Asn Val 
    370                 375                 380                 


Leu Glu Ser Arg Gly Asp Arg Asp Asp Pro Gly Ser Arg 
385                 390                 395         


<210>  11
<211>  390
<212>  PRT
<213>  Methanobrevibacter smithii

<400>  11

Met Gln Tyr Tyr Ile Ser His Tyr Asn Lys Glu Pro Glu Leu Asn Phe 
1               5                   10                  15      


Pro Asp Glu Ile Thr Val Tyr Asp Thr Thr Leu Arg Asp Gly Glu Gln 
            20                  25                  30          


Thr Pro Gly Val Cys Phe Ser Pro Glu Glu Lys Leu Glu Ile Ala Lys 
        35                  40                  45              


Lys Leu Asp Glu Val Lys Ile Lys Gln Ile Glu Ala Gly Phe Pro Ile 
    50                  55                  60                  


Val Ser Lys Lys Glu Gln Glu Ser Val Lys Ala Ile Thr Ser Glu Gly 
65                  70                  75                  80  


Leu Asn Ala Gln Ile Ile Ser Leu Ser Arg Thr Lys Lys Glu Asp Ile 
                85                  90                  95      


Asp Ala Ala Leu Asp Cys Asp Val Asp Gly Val Ile Thr Phe Met Gly 
            100                 105                 110         


Thr Ser Asp Ile His Leu Glu His Lys Met His Ile Gly Arg Gln Glu 
        115                 120                 125             


Ala Leu Asn Thr Cys Met Asn Ala Ile Glu Tyr Ala Lys Asp His Gly 
    130                 135                 140                 


Leu Phe Val Ala Phe Ser Ala Glu Asp Ala Thr Arg Thr Asp Leu Asp 
145                 150                 155                 160 


Phe Leu Lys Arg Ile Tyr Asn Lys Ala Glu Ser Tyr Gly Ala Asp Arg 
                165                 170                 175     


Val His Ile Ala Asp Thr Thr Gly Ala Ile Thr Pro Gln Gly Ile Thr 
            180                 185                 190         


Tyr Leu Val Lys Glu Leu Lys Lys Asp Val Asn Ile Asp Ile Ala Leu 
        195                 200                 205             


His Cys His Asn Asp Phe Gly Leu Ala Val Ile Asn Ser Ile Ser Gly 
    210                 215                 220                 


Val Leu Ala Gly Ala Asn Gly Ile Ser Thr Thr Val Asn Gly Ile Gly 
225                 230                 235                 240 


Glu Arg Ala Gly Asn Ala Ser Leu Glu Glu Val Ile Met Ser Leu Lys 
                245                 250                 255     


Leu Leu Tyr Gly Lys Asp Leu Gly Phe Lys Thr Lys His Ile Lys Glu 
            260                 265                 270         


Leu Ser Glu Leu Val Ser Lys Ala Ser Gly Leu Pro Val Pro Tyr Asn 
        275                 280                 285             


Lys Pro Val Val Gly Asn Asn Val Phe Arg His Glu Ser Gly Ile His 
    290                 295                 300                 


Val Asp Ala Val Ile Glu Glu Pro Leu Cys Tyr Glu Pro Tyr Ile Pro 
305                 310                 315                 320 


Glu Leu Val Gly Gln Lys Arg Gln Leu Val Leu Gly Lys His Ser Gly 
                325                 330                 335     


Cys Arg Ala Val Arg Ala Lys Leu Asn Glu Cys Asp Leu Asp Val Ser 
            340                 345                 350         


Asp Asp Thr Leu Ile Glu Ile Val Lys Lys Val Lys Lys Ser Arg Glu 
        355                 360                 365             


Glu Gly Thr Tyr Ile Asn Asp Asp Val Phe Lys Glu Ile Val Lys Ser 
    370                 375                 380                 


Cys Asn Tyr Lys Lys Glu 
385                 390 


<210>  12
<211>  386
<212>  PRT
<213>  Methanococcus vannielii

<400>  12

Met Asp Trp Lys Glu Val Ser Gln Tyr Asn Pro Lys Leu Asp Leu Lys 
1               5                   10                  15      


Glu Cys Tyr Val Tyr Asp Thr Thr Leu Arg Asp Gly Glu Gln Thr Pro 
            20                  25                  30          


Gly Val Cys Phe Thr Gly Asn Gln Lys Leu Glu Ile Ala Lys Lys Leu 
        35                  40                  45              


Asp Asp Leu Gly Ile Lys Gln Ile Glu Ala Gly Phe Pro Thr Val Ser 
    50                  55                  60                  


Glu Asn Glu Arg Lys Cys Ile Lys Ser Ile Ser Ser Glu Gly Leu Asn 
65                  70                  75                  80  


Ala Asp Ile Leu Ala Leu Ser Arg Val Leu Lys Glu Asp Ile Asp Arg 
                85                  90                  95      


Ala Ile Glu Cys Asp Val Asp Gly Ile Ile Thr Phe Val Ala Thr Ser 
            100                 105                 110         


Pro Met His Leu Lys Tyr Lys Leu His Lys Ser Phe Glu Glu Val Glu 
        115                 120                 125             


Glu Met Gly Met Lys Ala Ile Glu Tyr Ala Lys Asp His Gly Leu Phe 
    130                 135                 140                 


Val Ala Phe Ser Ala Glu Asp Ala Thr Arg Thr Ser Ile Glu Asn Ile 
145                 150                 155                 160 


Ile Lys Ile His Lys Asn Ala Glu Asp Tyr Gly Ala Asp Arg Val His 
                165                 170                 175     


Ile Ala Asp Thr Leu Gly Cys Ala Thr Pro Gln Ser Met Tyr Gln Ile 
            180                 185                 190         


Cys Ser Glu Leu Asn Lys Ser Leu Lys Lys Ala His Ile Gly Val His 
        195                 200                 205             


Cys His Asn Asp Phe Gly Phe Ala Ala Ile Asn Ser Ile Tyr Gly Leu 
    210                 215                 220                 


Met Gly Gly Ala Lys Ala Val Ser Thr Thr Val Asn Gly Ile Gly Glu 
225                 230                 235                 240 


Arg Ala Gly Asn Ala Ala Leu Glu Glu Val Val Met Ala Leu Lys Val 
                245                 250                 255     


Leu Tyr Asn Tyr Asp Met Gly Leu Asn Thr Glu Leu Ile Met Glu Thr 
            260                 265                 270         


Ser Lys Leu Val Glu Thr Tyr Ser Lys Ile Lys Val Pro Glu Asn Lys 
        275                 280                 285             


Pro Leu Val Gly Glu Met Val Phe Tyr His Glu Ser Gly Ile His Val 
    290                 295                 300                 


Asp Ala Val Leu Glu Asn Pro Leu Thr Tyr Glu Pro Phe Leu Pro Glu 
305                 310                 315                 320 


Lys Ile Gly Gln Lys Arg Lys Ile Val Leu Gly Lys His Ser Gly Cys 
                325                 330                 335     


Arg Ala Val Ala Tyr Arg Leu Asn Glu Leu Gly Phe Glu Ala Thr Arg 
            340                 345                 350         


Asp Glu Leu Trp Glu Ile Val Lys Lys Thr Lys Glu Thr Arg Glu Gln 
        355                 360                 365             


Gly Thr Glu Ile Ser Asp Glu Val Phe Lys Asn Ile Val Thr His Ile 
    370                 375                 380                 


Leu Asn 
385     


<210>  13
<211>  387
<212>  PRT
<213>  Methanococcus aeolicus

<400>  13

Met Asn Trp Lys Glu Val Cys Gln Tyr Asn Pro Lys Leu Asn Leu Glu 
1               5                   10                  15      


Asp Cys Tyr Ile Tyr Asp Thr Thr Leu Arg Asp Gly Glu Gln Thr Pro 
            20                  25                  30          


Gly Val Cys Phe Ser Met Glu Gln Lys Leu Asp Ile Ala Lys Lys Leu 
        35                  40                  45              


Asp Glu Leu Gly Val Lys Gln Ile Glu Ala Gly Phe Pro Ala Val Ser 
    50                  55                  60                  


Lys Ser Glu Ile Glu Asn Val Lys Lys Ile Ala Asn Glu Gly Leu Asn 
65                  70                  75                  80  


Ala Glu Ile Leu Ala Leu Ser Arg Ala Leu Gln Gly Asp Ile Asp Lys 
                85                  90                  95      


Ala Leu Ser Cys Asp Val Asp Gly Ile Ile Thr Phe Ile Ala Ala Ser 
            100                 105                 110         


Pro Leu His Leu Lys Tyr Lys Leu His Lys Ser Ile Glu Glu Val Glu 
        115                 120                 125             


Glu Met Gly Met Lys Ala Val Glu Tyr Ala Lys Asp His Gly Leu Phe 
    130                 135                 140                 


Val Ala Phe Ser Ala Glu Asp Ala Thr Arg Thr Pro Ile Glu Asp Leu 
145                 150                 155                 160 


Val Arg Ile His Lys Asn Ala Glu Glu His Gly Ala Asp Arg Val His 
                165                 170                 175     


Ile Ala Asp Thr Thr Gly Cys Gly Thr Pro Gln Ser Ile Gln Tyr Ile 
            180                 185                 190         


Cys Ser Glu Leu Ser Asn Asn Leu Lys Lys Ala His Ile Gly Val His 
        195                 200                 205             


Cys His Asn Asp Phe Gly Leu Ala Val Ile Asn Ser Ile Tyr Gly Leu 
    210                 215                 220                 


Leu Gly Gly Ala Lys Ala Ala Ser Thr Thr Val Asn Gly Ile Gly Glu 
225                 230                 235                 240 


Arg Ala Gly Asn Ala Pro Leu Glu Glu Leu Leu Leu Thr Met Asn Val 
                245                 250                 255     


Leu Tyr Asp Val Lys Thr Asp Leu Asn Ile Ser Ile Ile Lys Glu Leu 
            260                 265                 270         


Ser Thr Met Val Glu Asn Tyr Ser Gly Ile Lys Ile Pro Val Asn Lys 
        275                 280                 285             


Pro Ile Val Gly Asp Lys Val Phe Tyr His Glu Ser Gly Ile His Val 
    290                 295                 300                 


Asp Ala Val Ile Glu Asn Pro Leu Thr Tyr Glu Pro Phe Leu Pro Glu 
305                 310                 315                 320 


Arg Ile Gly Gln Lys Arg Glu Ile Val Leu Gly Lys His Ser Gly Cys 
                325                 330                 335     


Ser Ala Val Glu Ser Lys Leu Lys Glu Leu Gly Leu Glu Val Pro Lys 
            340                 345                 350         


Asp Arg Ile Trp Asp Leu Val Lys Lys Val Lys Thr Thr Arg Glu Gly 
        355                 360                 365             


Gly Glu Asp Ile Asp Asp Glu Met Phe Ile Lys Ile Val Asp Ile Ile 
    370                 375                 380                 


Asn Lys Gln 
385         


<210>  14
<211>  420
<212>  PRT
<213>  Methanococcus jannaschii

<400>  14

Met Thr Leu Val Glu Lys Ile Leu Ser Lys Lys Val Gly Tyr Glu Val 
1               5                   10                  15      


Cys Ala Gly Asp Ser Ile Glu Val Glu Val Asp Leu Ala Met Thr His 
            20                  25                  30          


Asp Gly Thr Thr Pro Leu Ala Tyr Lys Ala Leu Lys Glu Met Ser Asp 
        35                  40                  45              


Ser Val Trp Asn Pro Asp Lys Ile Val Val Ala Phe Asp His Asn Val 
    50                  55                  60                  


Pro Pro Asn Thr Val Lys Ala Ala Glu Met Gln Lys Leu Ala Leu Glu 
65                  70                  75                  80  


Phe Val Lys Arg Phe Gly Ile Lys Asn Phe His Lys Gly Gly Glu Gly 
                85                  90                  95      


Ile Cys His Gln Ile Leu Ala Glu Asn Tyr Val Leu Pro Asn Met Phe 
            100                 105                 110         


Val Ala Gly Gly Asp Ser His Thr Cys Thr His Gly Ala Phe Gly Ala 
        115                 120                 125             


Phe Ala Thr Gly Phe Gly Ala Thr Asp Met Ala Tyr Ile Tyr Ala Thr 
    130                 135                 140                 


Gly Glu Thr Trp Ile Lys Val Pro Lys Thr Ile Arg Val Asp Ile Val 
145                 150                 155                 160 


Gly Lys Asn Glu Asn Val Ser Ala Lys Asp Ile Val Leu Arg Val Cys 
                165                 170                 175     


Lys Glu Ile Gly Arg Arg Gly Ala Thr Tyr Met Ala Ile Glu Tyr Gly 
            180                 185                 190         


Gly Glu Val Val Lys Asn Met Asp Met Asp Gly Arg Leu Thr Leu Cys 
        195                 200                 205             


Asn Met Ala Ile Glu Met Gly Gly Lys Thr Gly Val Ile Glu Ala Asp 
    210                 215                 220                 


Glu Ile Thr Tyr Asp Tyr Leu Lys Lys Glu Arg Gly Leu Ser Asp Glu 
225                 230                 235                 240 


Asp Ile Ala Lys Leu Lys Lys Glu Arg Ile Thr Val Asn Arg Asp Glu 
                245                 250                 255     


Ala Asn Tyr Tyr Lys Glu Ile Glu Ile Asp Ile Thr Asp Met Glu Glu 
            260                 265                 270         


Gln Val Ala Val Pro His His Pro Asp Asn Val Lys Pro Ile Ser Asp 
        275                 280                 285             


Val Glu Gly Thr Glu Ile Asn Gln Val Phe Ile Gly Ser Cys Thr Asn 
    290                 295                 300                 


Gly Arg Leu Ser Asp Leu Arg Glu Ala Ala Lys Tyr Leu Lys Gly Arg 
305                 310                 315                 320 


Glu Val His Lys Asp Val Lys Leu Ile Val Ile Pro Ala Ser Lys Lys 
                325                 330                 335     


Val Phe Leu Gln Ala Leu Lys Glu Gly Ile Ile Asp Ile Phe Val Lys 
            340                 345                 350         


Ala Gly Ala Met Ile Cys Thr Pro Gly Cys Gly Pro Cys Leu Gly Ala 
        355                 360                 365             


His Gln Gly Val Leu Ala Glu Gly Glu Ile Cys Leu Ser Thr Thr Asn 
    370                 375                 380                 


Arg Asn Phe Lys Gly Arg Met Gly His Ile Asn Ser Tyr Ile Tyr Leu 
385                 390                 395                 400 


Ala Ser Pro Lys Ile Ala Ala Ile Ser Ala Val Lys Gly Tyr Ile Thr 
                405                 410                 415     


Asn Lys Leu Asp 
            420 


<210>  15
<211>  428
<212>  PRT
<213>  Methanothermobacter thermautotrophicus

<400>  15

Met Val Lys Met Asn Met Thr Glu Lys Ile Leu Ala Glu Ala Ala Gly 
1               5                   10                  15      


Leu Arg Glu Val Thr Pro Gly Glu Ile Ile Glu Ala Arg Val Asp Leu 
            20                  25                  30          


Ala Met Thr His Asp Gly Thr Ser Pro Pro Thr Ile Arg Thr Phe Arg 
        35                  40                  45              


Asp Ile Ala Ser Arg Gly Gly Pro Ala Arg Val Trp Asp Pro Glu Arg 
    50                  55                  60                  


Ile Val Met Val Phe Asp His Asn Val Pro Ala Asn Thr Ile Gly Ala 
65                  70                  75                  80  


Ala Glu Phe Gln Arg Val Thr Arg Glu Phe Ala Arg Glu Gln Gly Ile 
                85                  90                  95      


Val Asn Ile Phe Gln Asn Ala Ala Gly Ile Cys His Gln Val Leu Pro 
            100                 105                 110         


Glu Arg Gly Phe Val Arg Pro Gly Met Val Ile Val Gly Ala Asp Ser 
        115                 120                 125             


His Thr Cys Thr Tyr Gly Ala Phe Gly Ala Phe Ala Thr Gly Met Gly 
    130                 135                 140                 


Ala Thr Asp Met Ala Met Val Phe Ala Thr Gly Lys Thr Trp Phe Met 
145                 150                 155                 160 


Val Pro Glu Ala Met Arg Ile Glu Val Thr Gly Glu Pro Glu Gly His 
                165                 170                 175     


Val Tyr Ala Lys Asp Val Ile Leu His Ile Ile Gly Glu Ile Gly Val 
            180                 185                 190         


Asp Gly Ala Thr Tyr Arg Ser Val Glu Phe Thr Gly Asp Thr Ile Glu 
        195                 200                 205             


Ser Met Asp Val Ser Gly Arg Met Thr Ile Cys Asn Met Ala Val Glu 
    210                 215                 220                 


Met Gly Ala Lys Asn Gly Ile Met Glu Pro Asn Arg Gln Thr Leu Asp 
225                 230                 235                 240 


Tyr Val Arg Ala Arg Thr Gly Arg Glu Phe Arg Val Tyr Ser Ser Asp 
                245                 250                 255     


Glu Asp Ser Gln Tyr Leu Glu Asp His His Phe Asp Val Ser Asp Leu 
            260                 265                 270         


Glu Pro Gln Val Ala Cys Pro Asp Asp Val Asp Asn Val Tyr Pro Val 
        275                 280                 285             


His Arg Val Glu Gly Thr His Ile Asp Glu Ala Phe Leu Gly Ser Cys 
    290                 295                 300                 


Thr Asn Gly Arg Tyr Glu Asp Leu Lys Ile Ala Ala Glu Val Ile Gly 
305                 310                 315                 320 


Asp Arg Arg Val His Glu Asp Val Arg Phe Ile Val Ser Pro Ala Ser 
                325                 330                 335     


Arg Glu Ile Tyr Leu Lys Ala Leu Glu Asp Gly Ile Ile Glu Thr Phe 
            340                 345                 350         


Ile Arg Ala Gly Ala Ile Val Cys Asn Pro Gly Cys Gly Pro Cys Leu 
        355                 360                 365             


Gly Ala His Met Gly Val Leu Ala Pro Gly Glu Val Ser Ile Ala Thr 
    370                 375                 380                 


Thr Asn Arg Asn Phe Arg Gly Arg Met Gly Asp Pro Ala Ser Ser Val 
385                 390                 395                 400 


Tyr Leu Ala Asn Pro Ala Val Val Ala Glu Ser Ala Ile Glu Gly Val 
                405                 410                 415     


Ile Ser Ala Pro Gln Gln Glu Ala Gly Asn Gly Cys 
            420                 425             


<210>  16
<211>  418
<212>  PRT
<213>  Methanococcus maripaludis

<400>  16

Met Thr Leu Ala Glu Lys Ile Ile Ser Lys Asn Val Gly Lys Asn Val 
1               5                   10                  15      


Tyr Ala Lys Asp Ser Val Glu Ile Ser Val Asp Ile Ala Met Thr His 
            20                  25                  30          


Asp Gly Thr Thr Pro Leu Thr Val Lys Ala Phe Glu Gln Ile Ser Asp 
        35                  40                  45              


Lys Val Trp Asp Asn Glu Lys Ile Val Ile Ile Phe Asp His Asn Ile 
    50                  55                  60                  


Pro Ala Asn Thr Ser Lys Ala Ala Asn Met Gln Val Ile Thr Arg Glu 
65                  70                  75                  80  


Phe Ile Lys Lys Gln Gly Ile Lys Asn Tyr Tyr Leu Asp Gly Glu Gly 
                85                  90                  95      


Ile Cys His Gln Val Leu Pro Glu Lys Gly His Val Lys Pro Asn Met 
            100                 105                 110         


Ile Ile Ala Gly Ala Asp Ser His Thr Cys Thr His Gly Ala Phe Gly 
        115                 120                 125             


Ala Phe Ala Thr Gly Phe Gly Ala Thr Asp Met Gly Tyr Val Tyr Ala 
    130                 135                 140                 


Thr Gly Lys Thr Trp Leu Arg Val Pro Glu Thr Ile Arg Val Asn Val 
145                 150                 155                 160 


Thr Gly Glu Asn Glu Asn Ile Ser Gly Lys Asp Ile Ile Leu Lys Thr 
                165                 170                 175     


Cys Lys Glu Val Gly Arg Arg Gly Ala Thr Tyr Met Ser Leu Glu Tyr 
            180                 185                 190         


Gly Gly Asn Ala Val His Asn Leu Ser Met Asp Glu Arg Met Val Leu 
        195                 200                 205             


Ser Asn Met Ala Ile Glu Met Gly Gly Lys Ala Gly Ile Ile Glu Ala 
    210                 215                 220                 


Asp Asp Thr Thr Tyr Arg Tyr Leu Glu Asn Ala Gly Val Ser Arg Glu 
225                 230                 235                 240 


Glu Ile Leu Glu Leu Lys Lys Asn Lys Ile Thr Val Asp Glu Ser Glu 
                245                 250                 255     


Glu Asp Tyr Tyr Lys Thr Ile Glu Phe Asp Ile Thr Gly Met Glu Glu 
            260                 265                 270         


Gln Val Ala Cys Pro His His Pro Asp Asn Val Lys Gly Val Ser Glu 
        275                 280                 285             


Val Glu Gly Thr Glu Leu Asn Gln Val Phe Ile Gly Ser Cys Thr Asn 
    290                 295                 300                 


Gly Arg Leu Asn Asp Leu Arg Ile Ala Ala Lys Tyr Leu Lys Gly Lys 
305                 310                 315                 320 


Lys Val Asn Glu Asn Thr Arg Leu Ile Val Ile Pro Ala Ser Lys Ser 
                325                 330                 335     


Ile Phe Lys Glu Ala Leu Asn Glu Gly Leu Ile Asp Ile Phe Val Asp 
            340                 345                 350         


Ser Gly Ala Leu Ile Cys Thr Pro Gly Cys Gly Pro Cys Leu Gly Ala 
        355                 360                 365             


His Gln Gly Val Leu Gly Asp Gly Glu Val Cys Leu Ala Thr Thr Asn 
    370                 375                 380                 


Arg Asn Phe Lys Gly Arg Met Gly Asn Thr Asn Ala Gln Val Tyr Leu 
385                 390                 395                 400 


Ser Ser Pro Lys Ile Ala Ala Lys Ser Ala Val Lys Gly Tyr Ile Thr 
                405                 410                 415     


Asn Glu 
        


<210>  17
<211>  418
<212>  PRT
<213>  Methanococcus maripaludis

<400>  17

Met Thr Leu Ala Glu Lys Ile Ile Ser Lys Asn Val Gly Lys Asn Val 
1               5                   10                  15      


Tyr Ala Gly Asp Ser Val Glu Ile Asp Val Asp Val Ala Met Thr His 
            20                  25                  30          


Asp Gly Thr Thr Pro Leu Thr Val Lys Ala Phe Glu Gln Ile Ser Asp 
        35                  40                  45              


Lys Val Trp Asp Asn Glu Lys Ile Val Ile Ile Phe Asp His Asn Ile 
    50                  55                  60                  


Pro Ala Asn Thr Ser Lys Ala Ala Asn Met Gln Val Ile Thr Arg Glu 
65                  70                  75                  80  


Phe Ile Lys Lys Gln Gly Ile Lys Asn Tyr Tyr Leu Asp Gly Glu Gly 
                85                  90                  95      


Ile Cys His Gln Val Leu Pro Glu Lys Gly His Val Lys Pro Asn Met 
            100                 105                 110         


Ile Ile Ala Gly Ala Asp Ser His Thr Cys Thr His Gly Ala Phe Gly 
        115                 120                 125             


Ala Phe Ala Thr Gly Phe Gly Ala Thr Asp Met Gly Tyr Val Tyr Ala 
    130                 135                 140                 


Thr Gly Lys Thr Trp Leu Arg Val Pro Glu Thr Ile Gln Val Asn Val 
145                 150                 155                 160 


Thr Gly Glu Asn Glu Asn Ile Ser Gly Lys Asp Ile Ile Leu Lys Thr 
                165                 170                 175     


Cys Lys Glu Val Gly Arg Arg Gly Ala Thr Tyr Leu Ser Leu Glu Tyr 
            180                 185                 190         


Gly Gly Asn Ala Val Gln Asn Leu Asp Met Asp Glu Arg Met Val Leu 
        195                 200                 205             


Ser Asn Met Ala Ile Glu Met Gly Gly Lys Ala Gly Ile Ile Glu Ala 
    210                 215                 220                 


Asp Asp Thr Thr Tyr Lys Tyr Leu Glu Asn Ala Gly Val Ser Arg Glu 
225                 230                 235                 240 


Glu Ile Leu Asn Leu Lys Lys Asn Lys Ile Lys Val Asn Glu Ser Glu 
                245                 250                 255     


Glu Asn Tyr Tyr Lys Thr Phe Glu Phe Asp Ile Thr Asp Met Glu Glu 
            260                 265                 270         


Gln Ile Ala Cys Pro His His Pro Asp Asn Val Lys Gly Val Ser Glu 
        275                 280                 285             


Val Ser Gly Ile Glu Leu Asp Gln Val Phe Ile Gly Ser Cys Thr Asn 
    290                 295                 300                 


Gly Arg Leu Asn Asp Leu Arg Ile Ala Ala Lys His Leu Lys Gly Lys 
305                 310                 315                 320 


Lys Val Asn Glu Ser Thr Arg Leu Ile Val Ile Pro Ala Ser Lys Ser 
                325                 330                 335     


Ile Phe Lys Glu Ala Leu Lys Glu Gly Leu Ile Asp Thr Phe Val Asp 
            340                 345                 350         


Ser Gly Ala Leu Ile Cys Thr Pro Gly Cys Gly Pro Cys Leu Gly Ala 
        355                 360                 365             


His Gln Gly Val Leu Gly Asp Gly Glu Val Cys Leu Ala Thr Thr Asn 
    370                 375                 380                 


Arg Asn Phe Lys Gly Arg Met Gly Asn Thr Lys Ser Glu Val Tyr Leu 
385                 390                 395                 400 


Ser Ser Pro Ala Ile Ala Ala Lys Ser Ala Val Lys Gly Tyr Ile Thr 
                405                 410                 415     


Asn Glu 
        


<210>  18
<211>  418
<212>  PRT
<213>  Methanococcus maripaludis

<400>  18

Met Thr Leu Ala Glu Lys Ile Ile Ser Lys Asn Val Gly Lys Asn Val 
1               5                   10                  15      


Tyr Ala Gly Asp Ser Val Glu Ile Asp Val Asp Ile Ala Met Thr His 
            20                  25                  30          


Asp Gly Thr Thr Pro Leu Thr Val Lys Ala Phe Glu Gln Ile Ser Asp 
        35                  40                  45              


Lys Val Trp Asp Asn Glu Lys Ile Val Ile Ile Phe Asp His Asn Ile 
    50                  55                  60                  


Pro Ala Asn Thr Ser Lys Ala Ala Asn Met Gln Val Ile Thr Arg Glu 
65                  70                  75                  80  


Phe Ile Lys Lys His Gly Ile Lys Asn Tyr Tyr Leu Asp Gly Glu Gly 
                85                  90                  95      


Ile Cys His Gln Val Leu Pro Glu Lys Gly His Val Lys Pro Asn Met 
            100                 105                 110         


Ile Ile Ala Gly Ala Asp Ser His Thr Cys Thr His Gly Ala Phe Gly 
        115                 120                 125             


Ala Phe Ala Thr Gly Phe Gly Ala Thr Asp Met Gly Phe Val Tyr Ala 
    130                 135                 140                 


Thr Gly Lys Thr Trp Leu Arg Val Pro Glu Thr Ile Arg Val Asn Val 
145                 150                 155                 160 


Thr Gly Glu Asn Glu Asn Ile Ser Gly Lys Asp Ile Ile Leu Lys Thr 
                165                 170                 175     


Cys Lys Glu Val Gly Arg Ser Gly Ala Thr Tyr Met Ser Leu Glu Tyr 
            180                 185                 190         


Gly Gly Asn Ala Val Gln Asn Leu Glu Met Asn Glu Arg Met Val Leu 
        195                 200                 205             


Ser Asn Met Ala Ile Glu Met Gly Gly Lys Ala Gly Ile Ile Glu Ala 
    210                 215                 220                 


Asp Asp Thr Thr Tyr Lys Tyr Leu Glu Asn Ala Gly Val Ser Arg Glu 
225                 230                 235                 240 


Glu Ile Leu Asn Leu Lys Lys Asn Lys Ile Thr Val Asn Glu Ser Glu 
                245                 250                 255     


Glu Asn Tyr Tyr Lys Thr Ile Glu Phe Asp Ile Thr Asp Met Glu Glu 
            260                 265                 270         


Gln Ile Ala Cys Pro His Asn Pro Asp Asn Val Lys Gly Val Ser Glu 
        275                 280                 285             


Val Ser Gly Thr Glu Leu Asp Gln Val Phe Ile Gly Ser Cys Thr Asn 
    290                 295                 300                 


Gly Arg Leu Asn Asp Leu Arg Ile Ala Ala Lys Tyr Leu Lys Gly Lys 
305                 310                 315                 320 


Lys Val Asn Glu Asn Thr Arg Leu Ile Val Ile Pro Ala Ser Lys Ser 
                325                 330                 335     


Ile Phe Ala Gly Ala Leu Lys Glu Gly Leu Ile Asp Ile Phe Val Glu 
            340                 345                 350         


Ser Gly Ala Leu Ile Cys Thr Pro Gly Cys Gly Pro Cys Leu Gly Ala 
        355                 360                 365             


His Gln Gly Val Leu Gly Asp Gly Glu Val Cys Leu Ala Thr Thr Asn 
    370                 375                 380                 


Arg Asn Phe Lys Gly Arg Met Gly Asn Thr Lys Ala Glu Val Tyr Leu 
385                 390                 395                 400 


Ser Ser Pro Lys Ile Ala Ala Lys Ser Ala Val Lys Gly Tyr Ile Thr 
                405                 410                 415     


Asn Glu 
        


<210>  19
<211>  415
<212>  PRT
<213>  Methanosphaera stadtmanae

<400>  19

Met Asn Ile Ser Glu Lys Ile Leu Ala Lys Ala Ser Asn Lys Glu Glu 
1               5                   10                  15      


Val Ser Pro Gly Asp Thr Ile Thr Ala Asn Ile Asp Val Ala Met Ser 
            20                  25                  30          


His Asp Gly Thr Ser Pro Pro Thr Ile Lys Val Phe Glu Lys Ile Ala 
        35                  40                  45              


Asp Lys Val Trp Asp Pro Glu Lys Ile Val Leu Val Phe Asp His Val 
    50                  55                  60                  


Ile Pro Ala Asn Thr Ile Gly Ser Ala Glu Phe Gln Gln Val Val Arg 
65                  70                  75                  80  


Glu Phe Gly Lys Lys Gln Lys Ile Pro Asn Met Tyr Ile Gln Gly Glu 
                85                  90                  95      


Gly Val Cys His Glu Val Leu Pro Asp Tyr Gly His Val Lys Pro Ser 
            100                 105                 110         


Thr Val Ile Val Gly Ala Asp Ser His Thr Cys Thr Tyr Gly Ala Phe 
        115                 120                 125             


Gly Ala Phe Ser Thr Gly Leu Gly Ala Thr Asp Leu Ala Met Val Tyr 
    130                 135                 140                 


Ala Thr Gly Gln Thr Trp Phe Asn Val Pro Glu Ser Leu Lys Ile Asn 
145                 150                 155                 160 


Val Asn Gly Thr Leu Asn Glu Asn Val Tyr Ser Lys Asp Val Ile Leu 
                165                 170                 175     


Lys Ile Ile Lys Glu Leu Gly Ala Tyr Gly Ala Thr Tyr Lys Ser Leu 
            180                 185                 190         


Glu Phe His Gly Asp Thr Ile Asp Asn Met Ser Val Ala Ser Arg Leu 
        195                 200                 205             


Thr Met Thr Asn Met Ala Ile Glu Cys Gly Ala Lys Asn Gly Ile Met 
    210                 215                 220                 


Val Pro Asn Lys Gln Thr Lys Glu Tyr Leu Ser Gln Arg Gly Ile Thr 
225                 230                 235                 240 


Asp Tyr Thr Ile Thr Thr Ala Ser Lys Asp Ala Glu Tyr Glu Lys Ile 
                245                 250                 255     


Tyr Asp Phe Asp Val Asp Asp Leu Gln Pro Gln Ile Ala Cys Pro His 
            260                 265                 270         


Asn Val Asp Asn Val Glu Asp Ile Asp Lys Val Ala Gly Thr His Ile 
        275                 280                 285             


Asp Gln Ala Val Leu Gly Ser Cys Thr Asn Gly Arg Tyr Glu Asp Leu 
    290                 295                 300                 


Leu Gln Ala Ala Glu Val Ile Glu Gly His Lys Ile His Glu Asp Val 
305                 310                 315                 320 


Glu Leu Leu Val Phe Pro Ala Ser Arg His Val Tyr Glu Lys Ala Ile 
                325                 330                 335     


Glu Thr Gly Val Ile Gln Thr Leu Leu Lys Ser Asn Ala Ile Ile Cys 
            340                 345                 350         


Asn Pro Gly Cys Gly Pro Cys Leu Gly Ala His Met Gly Val Met Thr 
        355                 360                 365             


Asp Asp Met Thr Cys Ile Ser Thr Thr Asn Arg Asn Phe Leu Gly Arg 
    370                 375                 380                 


Met Gly Ser Ala Lys Ser Tyr Val Tyr Leu Ser Asn Pro Ala Val Val 
385                 390                 395                 400 


Ala Ala Ser Ala Ile Lys Gly Glu Ile Thr Asn Pro Ser Glu Ile 
                405                 410                 415 


<210>  20
<211>  418
<212>  PRT
<213>  Methanopyrus kandleri

<400>  20

Met Gly Lys Thr Met Ala Glu Lys Ile Leu Ser Arg Ala Ser Gly Glu 
1               5                   10                  15      


Asp Ala Glu Ala Gly Asp Ile Val Val Ala Asn Ile Asp Val Ala Met 
            20                  25                  30          


Val His Asp Ile Thr Gly Pro Ile Thr Val Gln Arg Leu Glu Glu Met 
        35                  40                  45              


Gly Val Glu Arg Val Trp Asp Pro Ser Lys Ile Val Val Leu Phe Asp 
    50                  55                  60                  


His Gln Val Pro Ala Asp Ser Val Glu Ala Ala Glu Asn His Lys Ile 
65                  70                  75                  80  


Met Arg Glu Phe Val Glu Glu Gln Gly Ile Glu His Phe Tyr Asp Val 
                85                  90                  95      


Arg Glu Gly Val Cys His Gln Val Leu Pro Glu Lys Gly His Val Arg 
            100                 105                 110         


Pro Gly Asp Val Ile Val Gly Ala Asp Ser His Thr Cys Thr His Gly 
        115                 120                 125             


Ala Leu Gly Ala Phe Ala Thr Gly Ile Gly Ser Thr Asp Met Ala Ala 
    130                 135                 140                 


Val Phe Ala Thr Gly Lys Leu Trp Phe Arg Val Pro Glu Thr Tyr Arg 
145                 150                 155                 160 


Val Glu Ile Thr Gly Glu Leu Pro Glu Gly Val Tyr Ala Lys Asp Val 
                165                 170                 175     


Val Leu Lys Val Thr Gly Glu Ile Gly Ala Asp Gly Ala Thr Tyr Met 
            180                 185                 190         


Ala Ile Glu Tyr His Gly Glu Val Val Arg Glu Met Ser Val Ser Asp 
        195                 200                 205             


Arg Met Cys Leu Cys Asn Met Ala Ile Glu Met Gly Ala Lys Thr Gly 
    210                 215                 220                 


Met Val Pro Pro Asp Glu Lys Thr Leu Glu Tyr Val Lys Lys Arg Ala 
225                 230                 235                 240 


Gly Thr Glu Gly Arg Pro Val Glu Pro Asp Pro Asp Ala Arg Tyr Glu 
                245                 250                 255     


Ala Glu Leu Thr Leu Asp Val Ser Asp Leu Glu Pro Gln Val Ala Lys 
            260                 265                 270         


Pro Phe Ser Pro Asp Asn Val Val Pro Val Gly Glu Val Glu Gly Ile 
        275                 280                 285             


Ala Ile Asp Gln Val Phe Ile Gly Ser Cys Thr Asn Gly Arg Tyr Glu 
    290                 295                 300                 


Asp Leu Lys Val Ala Ala Glu Val Leu Glu Gly Glu Glu Val His Asp 
305                 310                 315                 320 


Asp Val Arg Leu Ile Val Ile Pro Ala Ser Arg Glu Val Tyr His Arg 
                325                 330                 335     


Thr Leu Lys Asp Gly Val Leu Glu Val Leu His Glu Ala Gly Ala Leu 
            340                 345                 350         


Ile Cys Pro Pro Asn Cys Gly Pro Cys Leu Gly Gly His Met Gly Val 
        355                 360                 365             


Leu Ala Glu Gly Glu Arg Cys Val Ala Thr Ser Asn Arg Asn Phe Pro 
    370                 375                 380                 


Gly Arg Met Gly His Arg Glu Ser Glu Val Tyr Leu Ala Ser Pro Ala 
385                 390                 395                 400 


Thr Ala Ala Ala Ser Ala Ile Glu Gly Glu Ile Thr Asp Pro Arg Pro 
                405                 410                 415     


Tyr Leu 
        


<210>  21
<211>  417
<212>  PRT
<213>  Methanobrevibacter smithii

<400>  21

Met Asn Ile Thr Glu Lys Ile Leu Ser Ala Lys Ala Lys Lys Glu Val 
1               5                   10                  15      


Thr Pro Gly Glu Ile Ile Glu Ile Pro Val Asp Leu Ala Met Ser His 
            20                  25                  30          


Asp Gly Thr Ser Pro Pro Ala Ile Lys Thr Phe Glu Lys Val Ala Thr 
        35                  40                  45              


Lys Val Trp Asp Asn Glu Lys Ile Ala Ile Val Phe Asp His Asn Val 
    50                  55                  60                  


Pro Ala Asn Thr Ile Gly Ser Ala Glu Phe Gln Lys Val Cys Arg Asp 
65                  70                  75                  80  


Phe Ile Lys Lys Gln Lys Ile Thr Lys Asn Tyr Ile His Gly Asp Gly 
                85                  90                  95      


Ile Cys His Gln Val Leu Pro Glu Lys Gly Leu Val Glu Pro Gly Lys 
            100                 105                 110         


Val Ile Val Gly Ala Asp Ser His Thr Cys Thr Tyr Gly Ala Tyr Gly 
        115                 120                 125             


Ala Phe Ser Thr Gly Met Gly Ala Thr Asp Leu Ala Met Val Tyr Ala 
    130                 135                 140                 


Thr Gly Lys Thr Trp Phe Met Val Pro Glu Ala Ile Lys Met Glu Val 
145                 150                 155                 160 


Ser Gly Glu Leu Asn Ser Tyr Thr Ala Pro Lys Asp Ile Ile Leu Lys 
                165                 170                 175     


Ile Ile Gly Glu Val Gly Ile Ala Gly Ala Thr Tyr Lys Thr Ala Glu 
            180                 185                 190         


Phe Cys Gly Glu Thr Ile Glu Lys Met Gly Val Glu Gly Arg Ala Thr 
        195                 200                 205             


Ile Cys Asn Met Ala Ile Glu Met Gly Ala Lys Asn Gly Ile Met Glu 
    210                 215                 220                 


Pro Asn Lys Glu Val Ile Gln Tyr Val Ser Gln Arg Thr Gly Lys Lys 
225                 230                 235                 240 


Glu Ser Glu Leu Asn Ile Val Lys Ser Asp Glu Asp Ala Gln Tyr Ser 
                245                 250                 255     


Glu Glu Met His Phe Asp Ile Thr Asp Met Glu Pro Gln Ile Ala Cys 
            260                 265                 270         


Pro Asn Asp Val Asp Asn Val Lys Asp Ile Ser Lys Val Glu Gly Thr 
        275                 280                 285             


Ala Val Asp Gln Cys Leu Ile Gly Ser Cys Thr Asn Gly Arg Leu Ser 
    290                 295                 300                 


Asp Leu Lys Asp Ala Tyr Glu Ile Leu Lys Asp Asn Glu Ile Asn Asn 
305                 310                 315                 320 


Asp Thr Arg Leu Leu Ile Leu Pro Ala Ser Ala Glu Ile Tyr Lys Gln 
                325                 330                 335     


Ala Ile His Glu Gly Tyr Ile Asp Ala Phe Ile Asp Ala Gly Ala Ile 
            340                 345                 350         


Ile Cys Asn Pro Gly Cys Gly Pro Cys Leu Gly Gly His Met Gly Val 
        355                 360                 365             


Leu Ser Glu Gly Glu Thr Cys Leu Ser Thr Thr Asn Arg Asn Phe Lys 
    370                 375                 380                 


Gly Arg Met Gly Asp Pro Lys Ser Ser Val Tyr Leu Ala Asn Ser Lys 
385                 390                 395                 400 


Val Val Ala Ala Ser Ala Ile Glu Gly Val Ile Thr Asn Pro Lys Asp 
                405                 410                 415     


Leu 
    


<210>  22
<211>  418
<212>  PRT
<213>  Methanococcus vannielii

<400>  22

Met Thr Leu Ala Glu Ala Ile Leu Ser Lys Lys Leu Gly Lys Asn Val 
1               5                   10                  15      


Tyr Ala Lys Asp Ser Val Glu Ile Asp Val Asp Leu Ala Met Thr His 
            20                  25                  30          


Asp Gly Thr Thr Pro Leu Thr Val Lys Ala Phe Glu Glu Ile Ser Asp 
        35                  40                  45              


Arg Val Phe Asp Asn Lys Lys Ile Val Ile Val Phe Asp His Asn Ile 
    50                  55                  60                  


Pro Ala Asn Thr Ser Lys Ala Ala Asn Met Gln Ile Ile Thr Arg Asp 
65                  70                  75                  80  


Phe Ile Lys Lys His Asp Ile Lys Asn Tyr Tyr Leu Asp Gly Glu Gly 
                85                  90                  95      


Ile Cys His Gln Ile Leu Pro Glu Lys Gly His Val Lys Pro Asn Met 
            100                 105                 110         


Val Ile Val Gly Ala Asp Ser His Thr Cys Thr His Gly Ala Phe Gly 
        115                 120                 125             


Ala Phe Ala Thr Gly Phe Gly Ala Ser Asp Met Gly Tyr Val Tyr Ala 
    130                 135                 140                 


Thr Gly Lys Thr Trp Phe Arg Val Pro Glu Thr Ile Arg Val Asn Val 
145                 150                 155                 160 


Thr Gly Lys Asn Glu Asn Ile Ser Gly Lys Asp Ile Val Leu Lys Thr 
                165                 170                 175     


Cys Lys Glu Val Gly Arg Ser Gly Ala Thr Tyr Met Ala Leu Glu Tyr 
            180                 185                 190         


Gly Gly Ser Ala Val Lys Ala Leu Asn Met Asp Glu Arg Met Val Leu 
        195                 200                 205             


Cys Asn Met Ala Ile Glu Met Gly Gly Lys Val Gly Leu Ile Glu Ala 
    210                 215                 220                 


Asp His Thr Thr Tyr Asp Tyr Leu Lys Asn Ala Gly Val Ser Asn Gln 
225                 230                 235                 240 


Glu Ile Ala Glu Leu Gln Arg Asn Lys Ile Ser Ile Thr Glu Asn Glu 
                245                 250                 255     


Glu Thr Tyr Phe Lys Thr Val Glu Phe Asp Ile Thr Asp Met Glu Glu 
            260                 265                 270         


Gln Val Ala Cys Pro His His Pro Asp Asn Val Lys Gly Ile Ser Glu 
        275                 280                 285             


Val Leu Gly Thr Pro Ile Asp Gln Ile Phe Ile Gly Ser Cys Thr Asn 
    290                 295                 300                 


Gly His Ile Gly Asp Leu Arg Ile Ala Ala Lys Ile Leu Lys Gly Lys 
305                 310                 315                 320 


Ser Ile Asn Lys Asn Thr Arg Leu Ile Val Ile Pro Ala Ser Lys Ser 
                325                 330                 335     


Ile Leu Lys Gln Ala Leu Asn Glu Gly Leu Ile Asp Ile Phe Val Asp 
            340                 345                 350         


Phe Gly Ala Leu Ile Cys Ala Pro Gly Cys Gly Pro Cys Leu Gly Ala 
        355                 360                 365             


His Glu Gly Val Leu Gly Asp Gly Glu Val Cys Leu Ala Thr Thr Asn 
    370                 375                 380                 


Arg Asn Phe Lys Gly Arg Met Gly Asn Ile Asn Ser Glu Val Tyr Leu 
385                 390                 395                 400 


Ser Ser Pro Ala Ile Ala Ala Lys Ser Ala Ile Lys Gly His Ile Thr 
                405                 410                 415     


Asn Glu 
        


<210>  23
<211>  421
<212>  PRT
<213>  Methanococcus aeolicus

<400>  23

Met Thr Leu Ala Glu Glu Ile Leu Ser Lys Lys Val Gly Lys Lys Val 
1               5                   10                  15      


Lys Ala Gly Asp Val Val Glu Ile Asp Ile Asp Leu Ala Met Thr His 
            20                  25                  30          


Asp Gly Thr Thr Pro Leu Ser Ala Lys Ala Phe Lys Gln Ile Thr Asp 
        35                  40                  45              


Lys Val Trp Asp Asn Lys Lys Ile Val Ile Val Phe Asp His Asn Val 
    50                  55                  60                  


Pro Ala Asn Thr Leu Lys Ala Ala Asn Met Gln Lys Ile Thr Arg Glu 
65                  70                  75                  80  


Phe Ile Lys Glu Gln Asn Ile Ile Asn His Tyr Leu Asp Gly Glu Gly 
                85                  90                  95      


Val Cys His Gln Val Leu Pro Glu Asn Gly His Ile Gln Pro Asn Met 
            100                 105                 110         


Val Ile Ala Gly Gly Asp Ser His Thr Cys Thr Tyr Gly Ala Phe Gly 
        115                 120                 125             


Ala Phe Ala Thr Gly Phe Gly Ala Thr Asp Met Gly Asn Ile Tyr Ala 
    130                 135                 140                 


Thr Gly Lys Thr Trp Leu Lys Val Pro Lys Thr Ile Arg Ile Asn Val 
145                 150                 155                 160 


Asn Gly Glu Asn Asp Lys Ile Thr Gly Lys Asp Ile Ile Leu Lys Ile 
                165                 170                 175     


Cys Lys Glu Val Gly Arg Ser Gly Ala Thr Tyr Met Ala Leu Glu Tyr 
            180                 185                 190         


Gly Gly Glu Ala Ile Lys Lys Leu Ser Met Asp Glu Arg Met Val Leu 
        195                 200                 205             


Ser Asn Met Ala Ile Glu Met Gly Gly Lys Val Gly Leu Ile Glu Ala 
    210                 215                 220                 


Asp Glu Thr Thr Tyr Asn Tyr Leu Arg Asn Val Gly Ile Ser Glu Glu 
225                 230                 235                 240 


Lys Ile Leu Glu Leu Lys Lys Asn Gln Ile Thr Ile Asp Glu Asn Asn 
                245                 250                 255     


Ile Asp Asn Asp Asn Tyr Tyr Lys Ile Ile Asn Ile Asp Ile Thr Asp 
            260                 265                 270         


Met Glu Glu Gln Val Ala Cys Pro His His Pro Asp Asn Val Lys Asn 
        275                 280                 285             


Ile Ser Glu Val Lys Gly Ala Pro Ile Asn Gln Val Phe Ile Gly Ser 
    290                 295                 300                 


Cys Thr Asn Gly Arg Leu Asn Asp Leu Arg Ile Ala Ser Lys Tyr Leu 
305                 310                 315                 320 


Lys Gly Lys Lys Val His Asn Asp Val Arg Leu Ile Val Ile Pro Ala 
                325                 330                 335     


Ser Lys Ser Ile Phe Lys Gln Ala Leu Lys Glu Gly Leu Ile Asp Ile 
            340                 345                 350         


Phe Val Asp Ala Gly Ala Leu Ile Cys Thr Pro Gly Cys Gly Pro Cys 
        355                 360                 365             


Leu Gly Ala His Gln Gly Val Leu Gly Asp Gly Glu Val Cys Leu Ala 
    370                 375                 380                 


Thr Thr Asn Arg Asn Phe Lys Gly Arg Met Gly Asn Thr Thr Ala Glu 
385                 390                 395                 400 


Ile Tyr Leu Ser Ser Pro Ala Ile Ala Ala Lys Ser Ala Ile Lys Gly 
                405                 410                 415     


Tyr Ile Thr Asn Glu 
            420     


<210>  24
<211>  170
<212>  PRT
<213>  Methanococcus jannaschii

<400>  24

Met Ile Ile Lys Gly Arg Ala His Lys Phe Gly Asp Asp Val Asp Thr 
1               5                   10                  15      


Asp Ala Ile Ile Pro Gly Pro Tyr Leu Arg Thr Thr Asp Pro Tyr Glu 
            20                  25                  30          


Leu Ala Ser His Cys Met Ala Gly Ile Asp Glu Asn Phe Pro Lys Lys 
        35                  40                  45              


Val Lys Glu Gly Asp Val Ile Val Ala Gly Glu Asn Phe Gly Cys Gly 
    50                  55                  60                  


Ser Ser Arg Glu Gln Ala Val Ile Ala Ile Lys Tyr Cys Gly Ile Lys 
65                  70                  75                  80  


Ala Val Ile Ala Lys Ser Phe Ala Arg Ile Phe Tyr Arg Asn Ala Ile 
                85                  90                  95      


Asn Val Gly Leu Ile Pro Ile Ile Ala Asn Thr Asp Glu Ile Lys Asp 
            100                 105                 110         


Gly Asp Ile Val Glu Ile Asp Leu Asp Lys Glu Glu Ile Val Ile Thr 
        115                 120                 125             


Asn Lys Asn Lys Thr Ile Lys Cys Glu Thr Pro Lys Gly Leu Glu Arg 
    130                 135                 140                 


Glu Ile Leu Ala Ala Gly Gly Leu Val Asn Tyr Leu Lys Lys Arg Lys 
145                 150                 155                 160 


Leu Ile Gln Ser Lys Lys Gly Val Lys Thr 
                165                 170 


<210>  25
<211>  170
<212>  PRT
<213>  Methanothermobacter thermautotrophicus

<400>  25

Met Glu Gly Ile Ile Arg Gly Arg Val Trp Arg Phe Gly Asp Asn Val 
1               5                   10                  15      


Asp Thr Asp Met Ile Ile Pro Gly Arg Tyr Leu Arg Thr Phe Ser Leu 
            20                  25                  30          


Asp Glu Leu Ala Ser His Val Met Glu Gly Ala Arg Pro Glu Phe Ala 
        35                  40                  45              


Ser Gln Val Arg Lys Gly Asp Ile Ile Val Ala Gly Arg Asn Phe Gly 
    50                  55                  60                  


Cys Gly Ser Ser Arg Glu Gln Ala Pro Val Ala Leu Lys His Ala Gly 
65                  70                  75                  80  


Val Val Ala Ile Ile Ala Glu Ser Phe Ala Arg Ile Phe Tyr Arg Asn 
                85                  90                  95      


Ala Ile Asn Ile Gly Leu Pro Val Ile Met Ala Lys Val Asp Ala Asp 
            100                 105                 110         


Asp Gly Asp Glu Val Ser Ile Asp Leu Arg Ser Gly Gln Ile Arg Asn 
        115                 120                 125             


Leu Thr Ala Gly Ser Glu Tyr Arg Met Lys Pro Phe Asn Asp Tyr Met 
    130                 135                 140                 


Leu Ser Ile Leu Glu Asp Gly Gly Leu Val Asn His Tyr Leu Lys Thr 
145                 150                 155                 160 


Ile Asp Thr Gly Ile Ser Gly Asp Glu Gly 
                165                 170 


<210>  26
<211>  161
<212>  PRT
<213>  Methanococcus maripaludis

<400>  26

Met Lys Ile Thr Gly Lys Val His Leu Phe Gly Asp Asp Ile Asp Thr 
1               5                   10                  15      


Asp Ala Ile Ile Pro Gly Ala Tyr Leu Lys Thr Thr Asp Glu Tyr Glu 
            20                  25                  30          


Leu Ala Ser His Cys Met Ala Gly Ile Asp Glu Asn Phe Pro Glu Arg 
        35                  40                  45              


Val Glu Asp Gly Asp Phe Leu Val Ala Gly Glu Asn Phe Gly Cys Gly 
    50                  55                  60                  


Ser Ser Arg Glu Gln Ala Pro Ile Ala Ile Lys Tyr Cys Gly Ile Lys 
65                  70                  75                  80  


Ala Ile Ile Val Glu Ser Phe Ala Arg Ile Phe Tyr Arg Asn Cys Ile 
                85                  90                  95      


Asn Leu Gly Val Phe Pro Ile Glu Cys Lys Gly Ile Ser Lys His Val 
            100                 105                 110         


Lys Asp Gly Asp Val Ile Glu Leu Asp Leu Glu Glu Lys Lys Val Ile 
        115                 120                 125             


Leu Lys Asp Thr Val Leu Asp Cys Asn Leu Pro Thr Gly Thr Ala Lys 
    130                 135                 140                 


Asp Ile Met Asp Glu Gly Gly Leu Ile Asn Tyr Ala Lys Lys Gln Lys 
145                 150                 155                 160 


Asn 
    


<210>  27
<211>  161
<212>  PRT
<213>  Methanococcus maripaludis

<400>  27

Met Lys Ile Thr Gly Lys Val His Val Phe Gly Asp Asp Ile Asp Thr 
1               5                   10                  15      


Asp Ala Ile Ile Pro Gly Ala Tyr Leu Lys Thr Thr Asp Glu Tyr Glu 
            20                  25                  30          


Leu Ala Ser His Cys Met Ala Gly Ile Asp Glu Asp Phe Pro Glu Met 
        35                  40                  45              


Val Lys Glu Gly Asp Phe Leu Val Ala Gly Glu Asn Phe Gly Cys Gly 
    50                  55                  60                  


Ser Ser Arg Glu Gln Ala Pro Ile Ala Ile Lys Tyr Cys Gly Ile Lys 
65                  70                  75                  80  


Ala Ile Ile Val Glu Ser Phe Ala Arg Ile Phe Tyr Arg Asn Cys Ile 
                85                  90                  95      


Asn Leu Gly Val Phe Pro Ile Glu Cys Lys Gly Ile Ser Lys His Val 
            100                 105                 110         


Lys Asp Gly Asp Leu Ile Glu Leu Asp Leu Glu Asn Lys Lys Val Ile 
        115                 120                 125             


Leu Lys Asp Lys Val Leu Asp Cys His Ile Pro Thr Gly Thr Ala Lys 
    130                 135                 140                 


Asp Ile Met Asp Glu Gly Gly Leu Ile Asn Tyr Ala Lys Lys Gln Lys 
145                 150                 155                 160 


Asn 
    


<210>  28
<211>  161
<212>  PRT
<213>  Methanococcus maripaludis

<400>  28

Met Lys Ile Thr Gly Lys Val His Leu Phe Gly Asp Asp Val Asp Thr 
1               5                   10                  15      


Asp Ala Ile Ile Pro Gly Ala Tyr Leu Lys Thr Thr Asp Glu Tyr Glu 
            20                  25                  30          


Leu Ala Ser His Cys Met Ala Gly Ile Asp Glu Asp Phe Pro Glu Met 
        35                  40                  45              


Val Glu Glu Gly Asp Phe Leu Val Ala Gly Glu Asn Phe Gly Cys Gly 
    50                  55                  60                  


Ser Ser Arg Glu Gln Ala Pro Ile Ala Ile Lys Tyr Cys Gly Ile Lys 
65                  70                  75                  80  


Ala Ile Ile Val Glu Ser Phe Ala Arg Ile Phe Tyr Arg Asn Cys Ile 
                85                  90                  95      


Asn Leu Gly Val Phe Pro Ile Glu Cys Lys Gly Ile Ser Lys His Val 
            100                 105                 110         


Lys Asp Gly Asp Ser Ile Glu Leu Asp Leu Glu Asn Lys Lys Val Ile 
        115                 120                 125             


Leu Lys Asp Thr Val Leu Asn Cys His Leu Pro Thr Gly Thr Ala Lys 
    130                 135                 140                 


Glu Ile Met Asp Glu Gly Gly Leu Ile Asn Tyr Ala Lys Lys His Lys 
145                 150                 155                 160 


Asn 
    


<210>  29
<211>  163
<212>  PRT
<213>  Methanosphaera stadtmanae

<400>  29

Met Asp Ser Met Lys Gly Lys Val Trp Thr Phe Arg Asp Cys Ile Asp 
1               5                   10                  15      


Thr Asp Val Ile Ile Ala Gly Arg Tyr Leu Arg Thr Phe Asn Pro Glu 
            20                  25                  30          


Asp Leu Ala Ala His Val Met Glu Ala Glu Asp Pro Glu Phe Ser Ser 
        35                  40                  45              


Lys Val Gly Lys Gly Asp Ile Ile Val Gly Gly Trp Asn Phe Gly Cys 
    50                  55                  60                  


Gly Ser Ser Arg Glu Gln Ala Pro Val Ala Ile Lys Thr Ala Gly Val 
65                  70                  75                  80  


Ser Ala Val Ile Ala Lys Ser Phe Ala Arg Ile Phe Tyr Arg Asn Ala 
                85                  90                  95      


Ile Asn Ile Gly Leu Pro Val Ile Thr Ala Asp Ile Glu Val Asp Glu 
            100                 105                 110         


Gly Asp Ile Leu Glu Val Asn Ile Glu Asp Gly Ile Ile Ile Asn Glu 
        115                 120                 125             


Thr Thr Lys Lys Thr Phe Lys Ile Lys Pro Phe Asp Ala Glu Met Leu 
    130                 135                 140                 


Asp Ile Leu Glu Asn Gly Gly Leu Val Asn Gln Tyr Leu Lys Asn Lys 
145                 150                 155                 160 


Lys Glu Val 
            


<210>  30
<211>  170
<212>  PRT
<213>  Methanopyrus kandleri

<400>  30

Met Arg Asp Val Ile Arg Gly Arg Ala Trp Val Phe Gly Asp Asp Ile 
1               5                   10                  15      


Asp Thr Asp Gln Ile Ile Pro Gly Arg Tyr Leu Thr Thr Gln Asp Pro 
            20                  25                  30          


Glu Glu Leu Ala Lys His Val Met Glu Gly Ala Asp Pro Glu Phe Pro 
        35                  40                  45              


Glu Lys Val Arg Glu Gly Asp Val Ile Val Ala Gly Lys Asn Phe Gly 
    50                  55                  60                  


Cys Gly Ser Ser Arg Glu His Ala Pro Ile Ala Leu Lys Ala Ala Gly 
65                  70                  75                  80  


Ile Ala Cys Val Val Thr Arg Ser Phe Ala Arg Ile Phe Tyr Arg Asn 
                85                  90                  95      


Ala Ile Asn Leu Gly Leu Pro Leu Val Val Cys Pro Gly Val Asp Asp 
            100                 105                 110         


Ala Phe Glu Asp Gly Gln Gly Ile Glu Val Asn Leu Arg Glu Gly Tyr 
        115                 120                 125             


Val Arg Asn Leu Asp Thr Gly Glu Glu Leu Glu Ala Lys Pro Leu Pro 
    130                 135                 140                 


Asp Phe Met Met Arg Ile Leu Glu Ala Gly Gly Leu Val Glu Leu Ile 
145                 150                 155                 160 


Lys Arg Glu Gly Pro Arg Ala Phe Glu Gly 
                165                 170 


<210>  31
<211>  161
<212>  PRT
<213>  Methanobrevibacter smithii

<400>  31

Met Asp Ile Ile Lys Gly Lys Thr Trp Thr Phe Gly Glu Asn Ile Asp 
1               5                   10                  15      


Thr Asp Val Ile Ile Pro Gly Arg Tyr Leu Arg Thr Phe Asn Pro Gln 
            20                  25                  30          


Asp Leu Ala Asp His Val Leu Glu Gly Glu Arg Pro Asp Phe Thr Lys 
        35                  40                  45              


Asn Val Lys Lys Gly Asp Ile Ile Val Ala Asp Glu Asn Phe Gly Cys 
    50                  55                  60                  


Gly Ser Ser Arg Glu Gln Ala Pro Val Ala Ile Lys Thr Ala Gly Val 
65                  70                  75                  80  


Asp Ala Ile Val Ala Lys Ser Phe Ala Arg Ile Phe Tyr Arg Asn Ala 
                85                  90                  95      


Ile Asn Ile Gly Leu Pro Val Ile Val Cys Asp Ile Gln Ala Lys Asp 
            100                 105                 110         


Gly Asp Ile Ile Asn Ile Asp Leu Ser Lys Gly Ile Leu Thr Asn Glu 
        115                 120                 125             


Thr Thr Gly Glu Ser Val Thr Phe Glu Pro Phe Lys Glu Phe Met Leu 
    130                 135                 140                 


Asp Ile Leu Glu Asp Asn Gly Leu Val Asn His Tyr Leu Lys Glu Lys 
145                 150                 155                 160 


Gln 
    


<210>  32
<211>  161
<212>  PRT
<213>  Methanococcus vannielii

<400>  32

Met Lys Leu Lys Gly Lys Ala His Val Phe Ser Asp Asp Val Asp Thr 
1               5                   10                  15      


Asp Ala Ile Ile Pro Gly Ala Tyr Leu Arg Thr Thr Asp Val Tyr Glu 
            20                  25                  30          


Leu Ala Ser His Cys Met Ala Gly Ile Asp Glu Asn Phe Pro Lys Lys 
        35                  40                  45              


Val Asn Leu Gly Asp Phe Ile Val Ala Gly Glu Asn Phe Gly Cys Gly 
    50                  55                  60                  


Ser Ser Arg Glu Gln Ala Pro Ile Ser Ile Lys Tyr Leu Gly Ile Ser 
65                  70                  75                  80  


Ala Ile Ile Ala Glu Ser Phe Ala Arg Ile Phe Tyr Arg Asn Ser Ile 
                85                  90                  95      


Asn Leu Gly Val Ile Pro Ile Glu Cys Lys Asn Ile Ser Lys His Val 
            100                 105                 110         


Lys Thr Gly Asp Leu Ile Glu Leu Asp Leu Glu Asn Lys Lys Ile Ile 
        115                 120                 125             


Leu Lys Asp Ile Val Leu Glu Cys Thr Val Pro Thr Gly Lys Ala Lys 
    130                 135                 140                 


Glu Ile Ile Asp Leu Gly Gly Leu Ile Asn Tyr Ala Lys Ala Gln Met 
145                 150                 155                 160 


Gly 
    


<210>  33
<211>  165
<212>  PRT
<213>  Methanococcus aeolicus

<400>  33

Met Ile Ile Lys Gly Asn Ile His Leu Phe Gly Asp Asp Ile Asp Thr 
1               5                   10                  15      


Asp Ala Ile Ile Pro Gly Ala Tyr Leu Lys Thr Thr Asp Pro Lys Glu 
            20                  25                  30          


Leu Ala Ser His Cys Met Ala Gly Ile Asp Glu Lys Phe Ser Thr Lys 
        35                  40                  45              


Val Lys Asp Gly Asp Ile Ile Val Ala Gly Glu Asn Phe Gly Cys Gly 
    50                  55                  60                  


Ser Ser Arg Glu Gln Ala Pro Ile Ser Ile Lys His Thr Gly Ile Lys 
65                  70                  75                  80  


Ala Val Val Ala Glu Ser Phe Ala Arg Ile Phe Tyr Arg Asn Cys Ile 
                85                  90                  95      


Asn Ile Gly Leu Ile Pro Ile Thr Cys Glu Gly Ile Asn Glu Gln Ile 
            100                 105                 110         


Gln Asn Leu Lys Asp Gly Asp Thr Ile Glu Ile Asp Leu Gln Asn Glu 
        115                 120                 125             


Thr Ile Lys Ile Asn Ser Met Met Leu Asn Cys Gly Ala Pro Lys Gly 
    130                 135                 140                 


Ile Glu Lys Glu Ile Leu Asp Ala Gly Gly Leu Val Gln Tyr Thr Lys 
145                 150                 155                 160 


Asn Lys Leu Lys Lys 
                165 


<210>  34
<211>  347
<212>  PRT
<213>  Methanococcus jannaschii

<400>  34

Met Met Lys Val Cys Val Ile Glu Gly Asp Gly Ile Gly Lys Glu Val 
1               5                   10                  15      


Ile Pro Glu Ala Ile Lys Ile Leu Asn Glu Leu Gly Glu Phe Glu Ile 
            20                  25                  30          


Ile Lys Gly Glu Ala Gly Leu Glu Cys Leu Lys Lys Tyr Gly Asn Ala 
        35                  40                  45              


Leu Pro Glu Asp Thr Ile Glu Lys Ala Lys Glu Ala Asp Ile Ile Leu 
    50                  55                  60                  


Phe Gly Ala Ile Thr Ser Pro Lys Pro Gly Glu Val Gln Asn Tyr Lys 
65                  70                  75                  80  


Ser Pro Ile Ile Thr Leu Arg Lys Met Phe His Leu Tyr Ala Asn Val 
                85                  90                  95      


Arg Pro Ile Asn Asn Phe Gly Ile Gly Gln Leu Ile Gly Lys Ile Ala 
            100                 105                 110         


Asp Tyr Glu Phe Leu Asn Ala Lys Asn Ile Asp Ile Val Ile Ile Arg 
        115                 120                 125             


Glu Asn Thr Glu Asp Leu Tyr Val Gly Arg Glu Arg Leu Glu Asn Asp 
    130                 135                 140                 


Thr Ala Ile Ala Glu Arg Val Ile Thr Arg Lys Gly Ser Glu Arg Ile 
145                 150                 155                 160 


Ile Arg Phe Ala Phe Glu Tyr Ala Ile Lys Asn Asn Arg Lys Lys Val 
                165                 170                 175     


Ser Cys Ile His Lys Ala Asn Val Leu Arg Ile Thr Asp Gly Leu Phe 
            180                 185                 190         


Leu Glu Val Phe Asn Glu Ile Lys Lys His Tyr Asn Ile Glu Ala Asp 
        195                 200                 205             


Asp Tyr Leu Val Asp Ser Thr Ala Met Asn Leu Ile Lys His Pro Glu 
    210                 215                 220                 


Lys Phe Asp Val Ile Val Thr Thr Asn Met Phe Gly Asp Ile Leu Ser 
225                 230                 235                 240 


Asp Glu Ala Ser Ala Leu Ile Gly Gly Leu Gly Leu Ala Pro Ser Ala 
                245                 250                 255     


Asn Ile Gly Asp Asp Lys Ala Leu Phe Glu Pro Val His Gly Ser Ala 
            260                 265                 270         


Pro Asp Ile Ala Gly Lys Gly Ile Ala Asn Pro Met Ala Ser Ile Leu 
        275                 280                 285             


Ser Ile Ala Met Leu Phe Asp Tyr Ile Gly Glu Lys Glu Lys Gly Asp 
    290                 295                 300                 


Leu Ile Arg Glu Ala Val Lys Tyr Cys Leu Ile Asn Lys Lys Val Thr 
305                 310                 315                 320 


Pro Asp Leu Gly Gly Asp Leu Lys Thr Lys Asp Val Gly Asp Glu Ile 
                325                 330                 335     


Leu Asn Tyr Ile Arg Lys Lys Leu Lys Gly Tyr 
            340                 345         


<210>  35
<211>  331
<212>  PRT
<213>  Methanothermobacter thermautotrophicus

<400>  35

Met Tyr Arg Ile Thr Val Ile Pro Gly Asp Gly Ile Gly Val Glu Val 
1               5                   10                  15      


Met Glu Ala Ala Leu His Val Leu Gln Ala Leu Glu Ile Glu Phe Glu 
            20                  25                  30          


Phe Thr His Ala Glu Ala Gly Asn Glu Cys Phe Arg Arg Cys Gly Asp 
        35                  40                  45              


Thr Leu Pro Glu Glu Thr Leu Lys Leu Val Arg Lys Ala Asp Ala Thr 
    50                  55                  60                  


Leu Phe Gly Ala Val Thr Thr Val Pro Gly Gln Lys Ser Ala Ile Ile 
65                  70                  75                  80  


Thr Leu Arg Arg Glu Leu Asp Leu Phe Ala Asn Leu Arg Pro Val Lys 
                85                  90                  95      


Ser Leu Pro Gly Val Pro Cys Leu Tyr Pro Asp Leu Asp Phe Val Ile 
            100                 105                 110         


Val Arg Glu Asn Thr Glu Asp Leu Tyr Val Gly Asp Glu Glu Tyr Thr 
        115                 120                 125             


Pro Glu Gly Ala Val Ala Lys Arg Ile Ile Thr Arg Thr Ala Ser Arg 
    130                 135                 140                 


Arg Ile Ser Gln Phe Ala Phe Gln Tyr Ala Gln Lys Glu Gly Met Gln 
145                 150                 155                 160 


Lys Val Thr Ala Val His Lys Ala Asn Val Leu Lys Lys Thr Asp Gly 
                165                 170                 175     


Ile Phe Arg Asp Glu Phe Tyr Lys Val Ala Ser Glu Tyr Pro Gln Met 
            180                 185                 190         


Glu Ala Asn Asp Tyr Tyr Val Asp Ala Thr Ala Met Tyr Leu Ile Thr 
        195                 200                 205             


Gln Pro Gln Glu Phe Gln Thr Ile Val Thr Thr Asn Leu Phe Gly Asp 
    210                 215                 220                 


Ile Leu Ser Asp Glu Ala Ala Gly Leu Ile Gly Gly Leu Gly Leu Ala 
225                 230                 235                 240 


Pro Ser Ala Asn Ile Gly Glu Lys Asn Ala Leu Phe Glu Pro Val His 
                245                 250                 255     


Gly Ser Ala Pro Gln Ile Ala Gly Lys Asn Ile Ala Asn Pro Thr Ala 
            260                 265                 270         


Met Ile Leu Thr Thr Thr Leu Met Leu Lys His Leu Asn Lys Lys Gln 
        275                 280                 285             


Glu Ala Gln Lys Ile Glu Lys Ala Leu Gln Lys Thr Leu Met Arg Gly 
    290                 295                 300                 


Ile Met Thr Pro Asp Leu Gly Gly Thr Ala Ser Thr Met Glu Met Ala 
305                 310                 315                 320 


Glu Ala Ile Lys Glu Glu Ile Val Lys Gly Glu 
                325                 330     


<210>  36
<211>  339
<212>  PRT
<213>  Methanococcus maripaludis

<400>  36

Met Arg Asn Thr Pro Lys Ile Cys Val Ile Asn Gly Asp Gly Ile Gly 
1               5                   10                  15      


Asn Glu Val Val Pro Glu Thr Val Arg Val Leu Asn Glu Leu Gly Asp 
            20                  25                  30          


Phe Glu Phe Ile His Ala His Ala Gly Tyr Glu Cys Phe Lys Arg Cys 
        35                  40                  45              


Gly Asp Ala Ile Pro Glu Asn Thr Ile Glu Ile Ala Lys Glu Ser Asp 
    50                  55                  60                  


Cys Ile Leu Phe Gly Ser Val Thr Thr Pro Lys Pro Thr Glu Leu Lys 
65                  70                  75                  80  


Asn Lys Ser Tyr Arg Ser Pro Ile Leu Thr Leu Arg Lys Glu Leu Asp 
                85                  90                  95      


Leu Tyr Ala Asn Ile Arg Pro Thr Tyr Asn Phe Asp Asn Leu Asp Phe 
            100                 105                 110         


Val Ile Ile Arg Glu Asn Thr Glu Gly Leu Tyr Val Lys Lys Glu Tyr 
        115                 120                 125             


Tyr Asp Glu Lys Asn Glu Val Ala Ile Ala Glu Arg Ile Ile Ser Lys 
    130                 135                 140                 


Phe Gly Ser Ser Arg Ile Val Lys Phe Ala Phe Asp Tyr Ala Val Gln 
145                 150                 155                 160 


Asn Asn Arg Lys Lys Val Ser Cys Ile His Lys Ala Asn Val Leu Arg 
                165                 170                 175     


Val Thr Asp Gly Leu Phe Leu Glu Val Phe Glu Glu Met Ser Lys His 
            180                 185                 190         


Tyr Glu Lys Leu Gly Ile Lys Ser Asp Asp Tyr Leu Ile Asp Ala Thr 
        195                 200                 205             


Ala Met Tyr Leu Ile Arg Asn Pro Gln Met Phe Asp Val Leu Val Thr 
    210                 215                 220                 


Thr Asn Leu Phe Gly Asp Ile Leu Ser Asp Glu Ala Ala Gly Leu Ile 
225                 230                 235                 240 


Gly Gly Leu Gly Met Ser Pro Ser Ala Asn Ile Gly Asp Lys Asn Gly 
                245                 250                 255     


Leu Phe Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly 
            260                 265                 270         


Ile Ser Asn Pro Ile Ala Thr Ile Leu Ser Ala Ala Met Met Leu Asp 
        275                 280                 285             


His Leu Lys Met Asn Lys Glu Ala Glu Tyr Ile Arg Lys Ala Val Lys 
    290                 295                 300                 


Lys Thr Val Glu Cys Lys Tyr Leu Thr Pro Asp Leu Gly Gly Asn Leu 
305                 310                 315                 320 


Lys Thr Phe Glu Val Thr Glu Lys Ile Ile Glu Ser Ile Arg Ser Gln 
                325                 330                 335     


Met Ile Gln 
            


<210>  37
<211>  339
<212>  PRT
<213>  Methanococcus maripaludis

<400>  37

Met Arg Asn Thr Pro Lys Ile Cys Val Ile Asn Gly Asp Gly Ile Gly 
1               5                   10                  15      


Asn Glu Val Ile Pro Glu Thr Val Arg Val Leu Asn Glu Ile Gly Asp 
            20                  25                  30          


Phe Glu Phe Ile Glu Thr His Ala Gly Tyr Glu Cys Phe Lys Arg Cys 
        35                  40                  45              


Gly Asp Ala Ile Pro Glu Lys Thr Ile Glu Ile Ala Lys Glu Ser Asp 
    50                  55                  60                  


Ser Ile Leu Phe Gly Ser Val Thr Thr Pro Lys Pro Thr Glu Leu Lys 
65                  70                  75                  80  


Asn Lys Pro Tyr Arg Ser Pro Ile Leu Thr Leu Arg Lys Glu Leu Asp 
                85                  90                  95      


Leu Tyr Ala Asn Ile Arg Pro Thr Phe Asn Phe Lys Asn Leu Asp Phe 
            100                 105                 110         


Val Ile Ile Arg Glu Asn Thr Glu Gly Leu Tyr Val Lys Lys Glu Tyr 
        115                 120                 125             


Tyr Asp Glu Lys Asn Glu Val Ala Thr Ala Glu Arg Ile Ile Ser Lys 
    130                 135                 140                 


Phe Gly Ser Ser Arg Ile Val Lys Phe Ala Phe Asp Tyr Ala Leu Gln 
145                 150                 155                 160 


Asn Asn Arg Lys Lys Val Ser Cys Ile His Lys Ala Asn Val Leu Arg 
                165                 170                 175     


Ile Thr Asp Gly Leu Phe Leu Gly Val Phe Glu Glu Ile Ser Lys Lys 
            180                 185                 190         


Tyr Glu Lys Leu Gly Ile Val Ser Asp Asp Tyr Leu Ile Asp Ala Thr 
        195                 200                 205             


Ala Met Tyr Leu Ile Arg Asn Pro Gln Met Phe Asp Val Met Val Thr 
    210                 215                 220                 


Thr Asn Leu Phe Gly Asp Ile Leu Ser Asp Glu Ala Ala Gly Leu Ile 
225                 230                 235                 240 


Gly Gly Leu Gly Met Ser Pro Ser Ala Asn Ile Gly Asp Lys Asn Gly 
                245                 250                 255     


Leu Phe Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly 
            260                 265                 270         


Ile Ser Asn Pro Ile Ala Thr Ile Leu Ser Ala Ala Met Met Leu Asp 
        275                 280                 285             


His Leu Lys Ile Asn Lys Glu Ala Glu Tyr Ile Arg Asn Ala Val Lys 
    290                 295                 300                 


Lys Thr Val Glu Cys Lys Tyr Leu Thr Pro Asp Leu Gly Gly His Leu 
305                 310                 315                 320 


Lys Thr Ser Glu Val Thr Glu Lys Ile Ile Glu Ser Ile Lys Ser Gln 
                325                 330                 335     


Met Ile Gln 
            


<210>  38
<211>  339
<212>  PRT
<213>  Methanococcus maripaludis

<400>  38

Met Arg Asn Thr Pro Lys Ile Cys Val Ile Asn Gly Asp Gly Ile Gly 
1               5                   10                  15      


Asn Glu Val Ile Pro Glu Thr Val Arg Val Leu Ser Glu Ile Gly Asp 
            20                  25                  30          


Phe Glu Phe Ile Glu Thr His Ala Gly Tyr Glu Cys Phe Lys Arg Cys 
        35                  40                  45              


Gly Asp Ala Ile Pro Glu Lys Thr Ile Glu Ile Ala Lys Glu Ser Asp 
    50                  55                  60                  


Ser Ile Leu Phe Gly Ser Val Thr Thr Pro Lys Pro Thr Glu Leu Lys 
65                  70                  75                  80  


Asn Lys Pro Tyr Arg Ser Pro Ile Leu Thr Leu Arg Lys Glu Leu Asp 
                85                  90                  95      


Leu Tyr Ala Asn Ile Arg Pro Thr Phe Asn Phe Lys Asp Leu Asp Phe 
            100                 105                 110         


Val Ile Ile Arg Glu Asn Thr Glu Gly Leu Tyr Val Lys Lys Glu Tyr 
        115                 120                 125             


Tyr Asp Glu Lys Asn Glu Val Ala Ile Ala Glu Arg Val Ile Ser Lys 
    130                 135                 140                 


Phe Gly Ser Ser Arg Ile Val Lys Tyr Ala Phe Asp Tyr Ala Leu Gln 
145                 150                 155                 160 


Asn Asn Arg Lys Lys Val Ser Cys Ile His Lys Ala Asn Val Leu Arg 
                165                 170                 175     


Ile Thr Asp Gly Leu Phe Leu Glu Val Phe Glu Glu Ile Ser Lys Lys 
            180                 185                 190         


Tyr Glu Lys Leu Gly Ile Ala Ser Asp Asp Tyr Leu Ile Asp Ala Thr 
        195                 200                 205             


Ala Met Tyr Leu Ile Arg Asn Pro Gln Met Phe Asp Val Met Val Thr 
    210                 215                 220                 


Thr Asn Leu Phe Gly Asp Ile Leu Ser Asp Glu Ala Ala Gly Leu Ile 
225                 230                 235                 240 


Gly Gly Leu Gly Met Ser Pro Ser Ala Asn Ile Gly Asp Lys Asn Gly 
                245                 250                 255     


Leu Phe Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly 
            260                 265                 270         


Ile Ser Asn Pro Ile Ala Ser Ile Leu Ser Ala Ala Met Met Leu Asp 
        275                 280                 285             


His Leu Asn Met Asn Lys Glu Ala Glu Cys Ile Arg Asn Ala Val Lys 
    290                 295                 300                 


Lys Ala Val Glu Cys Lys Tyr Leu Thr Pro Asp Leu Gly Gly Asn Leu 
305                 310                 315                 320 


Lys Thr Ser Glu Val Thr Asp Lys Ile Ile Glu Ser Ile Lys Ser Gln 
                325                 330                 335     


Met Val Gln 
            


<210>  39
<211>  323
<212>  PRT
<213>  Methanosphaera stadtmanae

<400>  39

Met Tyr Lys Ile Thr Val Ile Pro Gly Asp Gly Ile Gly Gln Glu Val 
1               5                   10                  15      


Met Gln Pro Thr Ile Asp Ile Leu Glu Thr Leu Asn Ser Lys Phe Glu 
            20                  25                  30          


Phe Ile Pro Lys Glu Ala Gly Lys Glu Cys Tyr Gln Lys Tyr Asp Thr 
        35                  40                  45              


Asn Leu Pro Glu Glu Thr Ile Val Gln Cys Arg Glu Ser Asp Ser Thr 
    50                  55                  60                  


Leu Phe Gly Ala Val Thr Ser Ile Pro Gln Gln Lys Ser Ala Ile Val 
65                  70                  75                  80  


Thr Leu Arg Lys Glu Leu Asp Leu Tyr Val Asn Gln Arg Pro Ile His 
                85                  90                  95      


Ser Tyr Thr Asn Pro Asp Ile Asp Phe Thr Ile Ile Arg Glu Asn Ser 
            100                 105                 110         


Glu Gly Leu Tyr Ser His Ile Glu Glu Ser Thr Gly Asp Glu Ala Ile 
        115                 120                 125             


Ala Ile Arg Lys Ile Thr Tyr Lys Ala Ser Glu Arg Ile Ile Asn Tyr 
    130                 135                 140                 


Ala Phe Asn Tyr Ala Leu Lys Thr Glu Lys Ser Lys Val Thr Ala Ser 
145                 150                 155                 160 


His Lys Ala Asn Val Leu Pro Val Thr Asp Gly Ile Phe Lys Asn Thr 
                165                 170                 175     


Phe Tyr Lys Val Ala Ser Asn Tyr Pro Thr Ile Lys Ser Asn Asp Tyr 
            180                 185                 190         


Tyr Ile Asp Ala Met Ala Met Tyr Leu Ile Thr Asn Pro Ala Gln Phe 
        195                 200                 205             


Asp Ile Ile Val Thr Thr Asn Leu Phe Gly Asp Ile Leu Ser Asp Glu 
    210                 215                 220                 


Gly Gly Gly Leu Val Gly Thr Leu Gly Leu Ile Pro Ser Ala Asn Ile 
225                 230                 235                 240 


Gly Asp Lys Thr Gly Leu Phe Glu Pro Val His Gly Ser Ala Pro Asp 
                245                 250                 255     


Ile Ala Gly Leu Asn Lys Ala Asn Pro Ile Ala Met Ile Leu Ser Ser 
            260                 265                 270         


Cys Leu Met Leu Glu Tyr Leu Gly Leu Tyr Asp Asp Ala Lys Arg Ile 
        275                 280                 285             


Gln Asn Ala Val Glu Glu Thr Ile Ser Glu Ser Lys Val Lys Thr Pro 
    290                 295                 300                 


Asp Met Gly Gly His Asn Asn Thr Gln Asp Val Ala Asn Asn Ile Leu 
305                 310                 315                 320 


His Arg Leu 
            


<210>  40
<211>  335
<212>  PRT
<213>  Methanopyrus kandleri

<400>  40

Met Ala Tyr Lys Ile Ala Val Ile Pro Gly Asp Gly Ile Gly Pro Glu 
1               5                   10                  15      


Val Ile Glu Ala Ala Leu His Val Ile Glu Pro Leu Ile Asp Ala Glu 
            20                  25                  30          


Phe Val Glu Gly Glu Ala Gly Asp Glu Cys Ala Glu Lys His Gly Asp 
        35                  40                  45              


Pro Leu Pro Glu Asp Thr Leu Glu Leu Cys His Glu Ala Asp Ala Ile 
    50                  55                  60                  


Leu Phe Gly Ala Ala Gly Glu Thr Ala Ala Asp Val Ile Val Arg Leu 
65                  70                  75                  80  


Arg Gln Glu Leu Asp Leu Tyr Ala Asn Ile Arg Pro Val Arg Gly Phe 
                85                  90                  95      


Pro Gly Leu Arg Glu Leu Thr Gly Glu Pro Tyr Val Arg Asp Asp Val 
            100                 105                 110         


Asp Phe Val Ile Val Arg Glu Asn Thr Glu Gly Leu Tyr Ser Gly Ile 
        115                 120                 125             


Glu Gly Arg Phe Arg Asp Thr Ala Tyr Thr Leu Arg Ile Ile Thr Glu 
    130                 135                 140                 


Glu Gly Thr Arg Arg Ile Ala Glu Val Ala Cys Asp Leu Ala Glu Glu 
145                 150                 155                 160 


Arg Gly Ser Asn Thr Val Thr Cys Val His Lys Ala Asn Val Met Arg 
                165                 170                 175     


Glu Thr Cys Gly Leu Phe Arg Glu Val Cys Lys Glu Val Val Glu Ser 
            180                 185                 190         


Arg Gly Leu Glu Phe Glu Glu Tyr Tyr Val Asp Ala Ala Ala Met Phe 
        195                 200                 205             


Met Ile Thr Glu Pro Glu Arg Phe Asp Val Val Val Thr Pro Asn Met 
    210                 215                 220                 


Phe Gly Asp Ile Leu Ser Asp Glu Ala Ala Ala Leu Val Gly Gly Leu 
225                 230                 235                 240 


Gly Leu Ala Pro Ser Gly Asn Val Gly Asp Arg His Gly Leu Phe Glu 
                245                 250                 255     


Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly Ile Ala Asn 
            260                 265                 270         


Pro Phe Ala Thr Ile Leu Ser Ala Val Met Met Leu Glu Trp Leu Gly 
        275                 280                 285             


Glu Asp Glu Ala Ala Glu Ala Val Arg Glu Ala Val Gly Glu Ala Ile 
    290                 295                 300                 


Arg Glu Gly Val Val Thr Pro Asp Leu Gly Gly Asp Lys Lys Thr Met 
305                 310                 315                 320 


Glu Val Ala Glu Phe Val Arg Glu Ala Ala Leu Asn Arg Val Gln 
                325                 330                 335 


<210>  41
<211>  336
<212>  PRT
<213>  Methanobrevibacter smithii

<400>  41

Met Ser Thr Ser Asn Lys Lys Asp Asn Lys Tyr Gln Ile Ala Val Ile 
1               5                   10                  15      


Pro Gly Asp Gly Ile Gly Lys Glu Val Met Glu Ala Thr Ile Ser Val 
            20                  25                  30          


Leu Asp Glu Leu Asp Val Asp Phe Asp Tyr Ile Tyr Gly Ile Ala Gly 
        35                  40                  45              


Asp Glu Cys Asn Glu Glu His Gly Thr Pro Leu Pro Gln Glu Thr Ile 
    50                  55                  60                  


Asp Ile Val Arg Asp Ser Asp Ala Cys Leu Phe Gly Ala Ala Gly Glu 
65                  70                  75                  80  


Thr Ala Ala Asp Val Ile Val Lys Ile Arg Gln Glu Met Lys Met Phe 
                85                  90                  95      


Ala Asn Leu Arg Pro Val Lys Ser Tyr Pro Asn Thr Lys Ser Leu Phe 
            100                 105                 110         


Glu Asn Val Asp Phe Met Ile Val Arg Glu Asn Thr Glu Gly Leu Tyr 
        115                 120                 125             


Ile Ala Asp Gln Glu Glu Glu Thr Glu Asp Gly Ala Ile Ala Lys Arg 
    130                 135                 140                 


Val Ile Thr Arg Glu Ala Glu Glu Arg Ile Ile Asp Tyr Ala Phe Gln 
145                 150                 155                 160 


Tyr Ala Lys Asp Asn Asn Arg Thr Lys Val Thr Ala Val His Lys Ala 
                165                 170                 175     


Asn Val Leu Lys Lys Thr Asp Gly Leu Phe Lys Lys Ile Phe Tyr Glu 
            180                 185                 190         


Val Gly Glu Lys Tyr Pro Asp Ile Asp Thr Glu Asp Phe Tyr Val Asp 
        195                 200                 205             


Ala Thr Ala Met Tyr Leu Val Thr Gln Pro Gln Glu Phe Gln Val Val 
    210                 215                 220                 


Val Thr Thr Asn Leu Phe Gly Asp Ile Leu Ser Asp Glu Gly Ala Gly 
225                 230                 235                 240 


Leu Val Gly Gly Leu Gly Leu Ile Pro Ser Ala Asn Ile Gly Ala Asp 
                245                 250                 255     


Gly Ala Leu Phe Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly 
            260                 265                 270         


Gln Gln Lys Ala Asn Pro Ile Ala Met Met Leu Ser Ala Ile Met Met 
        275                 280                 285             


Leu Arg Tyr Leu Gly Glu Asn Asp Ala Ala Asp Lys Phe Asp Ala Ala 
    290                 295                 300                 


Ile Leu Lys Val Leu Ser Glu Gly Lys Thr Leu Thr Gly Asp Leu Gly 
305                 310                 315                 320 


Gly Ser Ala Thr Thr Met Glu Val Ala Gln Ala Val Lys Asn Ala Leu 
                325                 330                 335     


<210>  42
<211>  337
<212>  PRT
<213>  Methanococcus vannielii

<400>  42

Met Gly Tyr Met Pro Lys Ile Cys Val Ile Thr Gly Asp Gly Ile Gly 
1               5                   10                  15      


Lys Glu Val Val Pro Glu Thr Leu Arg Val Leu Asn Glu Val His Asp 
            20                  25                  30          


Phe Glu Tyr Ile Glu Ala His Ala Gly Tyr Glu Cys Phe Lys Arg Cys 
        35                  40                  45              


Gly Glu Ser Ile Pro Glu Ser Thr Ile Gln Thr Ala Lys Asn Ser Asp 
    50                  55                  60                  


Ser Ile Leu Phe Gly Ser Val Thr Thr Pro Lys Pro Thr Glu Leu Lys 
65                  70                  75                  80  


Asn Lys Pro Tyr Arg Ser Pro Ile Leu Thr Leu Arg Gln Glu Leu Asp 
                85                  90                  95      


Leu Tyr Ala Asn Ile Arg Pro Thr Tyr Asn Phe Lys Asp Leu Asp Phe 
            100                 105                 110         


Val Ile Ile Arg Glu Asn Thr Glu Cys Leu Tyr Val Lys Arg Glu Tyr 
        115                 120                 125             


Tyr Asp Glu Ile Asn Glu Val Ala Ile Ala Glu Arg Ile Ile Ser Lys 
    130                 135                 140                 


Lys Gly Ser Glu Arg Ile Ile Lys Phe Ala Phe Glu Tyr Ala Arg Leu 
145                 150                 155                 160 


Asn Asn Arg Lys Lys Val Ser Cys Ile His Lys Ala Asn Val Leu Arg 
                165                 170                 175     


Val Thr Asp Gly Leu Phe Leu Glu Ile Phe Glu Lys Ile Ala Lys Leu 
            180                 185                 190         


Tyr Glu Asn Phe Gly Ile Ser Ser Asn Asp Tyr Leu Ile Asp Ala Thr 
        195                 200                 205             


Ala Met Tyr Leu Ile Lys Asn Pro Tyr Met Phe Asp Val Met Val Thr 
    210                 215                 220                 


Thr Asn Leu Phe Gly Asp Ile Leu Ser Asp Glu Ala Ala Gly Leu Ile 
225                 230                 235                 240 


Gly Gly Leu Gly Met Ser Pro Ser Ala Asn Ile Gly Asp Asn Leu Gly 
                245                 250                 255     


Leu Phe Glu Pro Val His Gly Ser Ala Pro Asp Ile Ala Gly Lys Gly 
            260                 265                 270         


Ile Ser Asn Pro Ile Ala Thr Ile Leu Ser Ala Ser Met Met Leu Asp 
        275                 280                 285             


His Leu Lys Met Asn Lys Lys Ala Glu Ile Ile Arg Asn Ala Val Lys 
    290                 295                 300                 


Lys Thr Ile Asn Asn Gly Tyr Leu Thr Pro Asp Leu Gly Gly Ser Leu 
305                 310                 315                 320 


Lys Thr Ser Glu Val Val Asn Lys Val Ile Glu Phe Ile Arg Asp Glu 
                325                 330                 335     


Ile 
    


<210>  43
<211>  343
<212>  PRT
<213>  Methanococcus aeolicus

<400>  43

Met Lys Ile Pro Lys Ile Cys Val Ile Glu Gly Asp Gly Ile Gly Lys 
1               5                   10                  15      


Glu Val Ile Pro Glu Thr Val Arg Ile Leu Lys Glu Ile Gly Asp Phe 
            20                  25                  30          


Glu Phe Ile Tyr Glu His Ala Gly Tyr Glu Cys Phe Lys Arg Cys Gly 
        35                  40                  45              


Asp Ala Ile Pro Glu Lys Thr Leu Lys Thr Ala Lys Glu Cys Asp Ala 
    50                  55                  60                  


Ile Leu Phe Gly Ala Val Ser Thr Pro Lys Leu Asp Glu Thr Glu Arg 
65                  70                  75                  80  


Lys Pro Tyr Lys Ser Pro Ile Leu Thr Leu Arg Lys Glu Leu Asp Leu 
                85                  90                  95      


Tyr Ala Asn Val Arg Pro Ile His Lys Leu Asp Asn Ser Asp Ser Ser 
            100                 105                 110         


Asn Asn Ile Asp Phe Ile Ile Ile Arg Glu Asn Thr Glu Gly Leu Tyr 
        115                 120                 125             


Ser Gly Val Glu Tyr Tyr Asp Glu Glu Lys Glu Leu Ala Ile Ser Glu 
    130                 135                 140                 


Arg His Ile Ser Lys Lys Gly Ser Lys Arg Ile Ile Lys Phe Ala Phe 
145                 150                 155                 160 


Glu Tyr Ala Val Lys His His Arg Lys Lys Val Ser Cys Ile His Lys 
                165                 170                 175     


Ser Asn Ile Leu Arg Ile Thr Asp Gly Leu Phe Leu Asn Ile Phe Asn 
            180                 185                 190         


Glu Phe Lys Glu Lys Tyr Lys Asn Glu Tyr Asn Ile Glu Gly Asn Asp 
        195                 200                 205             


Tyr Leu Val Asp Ala Thr Ala Met Tyr Ile Leu Lys Ser Pro Gln Met 
    210                 215                 220                 


Phe Asp Val Ile Val Thr Thr Asn Leu Phe Gly Asp Ile Leu Ser Asp 
225                 230                 235                 240 


Glu Ala Ser Gly Leu Leu Gly Gly Leu Gly Leu Ala Pro Ser Ala Asn 
                245                 250                 255     


Ile Gly Asp Asn Tyr Gly Leu Phe Glu Pro Val His Gly Ser Ala Pro 
            260                 265                 270         


Asp Ile Ala Gly Lys Gly Val Ala Asn Pro Ile Ala Ala Val Leu Ser 
        275                 280                 285             


Ala Ser Met Met Leu Tyr Tyr Leu Asp Met Lys Glu Lys Ser Arg Leu 
    290                 295                 300                 


Leu Lys Asp Ala Val Lys Gln Val Leu Ala His Lys Asp Ile Thr Pro 
305                 310                 315                 320 


Asp Leu Gly Gly Asn Leu Lys Thr Lys Glu Val Ser Asp Lys Ile Ile 
                325                 330                 335     


Glu Glu Leu Arg Lys Ile Ser 
            340             


<210>  44
<211>  440
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  44

Met Ser Glu Asn Asn Glu Phe Gln Ser Val Thr Glu Ser Thr Thr Ala 
1               5                   10                  15      


Pro Thr Thr Ser Asn Pro Tyr Gly Pro Asn Pro Ala Asp Tyr Leu Ser 
            20                  25                  30          


Asn Val Lys Asn Phe Gln Leu Ile Asp Ser Thr Leu Arg Glu Gly Glu 
        35                  40                  45              


Gln Phe Ala Asn Ala Phe Phe Asp Thr Glu Lys Lys Ile Glu Ile Ala 
    50                  55                  60                  


Arg Ala Leu Asp Asp Phe Gly Val Asp Tyr Ile Glu Leu Thr Ser Pro 
65                  70                  75                  80  


Val Ala Ser Glu Gln Ser Arg Lys Asp Cys Glu Ala Ile Cys Lys Leu 
                85                  90                  95      


Gly Leu Lys Ala Lys Ile Leu Thr His Ile Arg Cys His Met Asp Asp 
            100                 105                 110         


Ala Arg Val Ala Val Glu Thr Gly Val Asp Gly Val Asp Val Val Ile 
        115                 120                 125             


Gly Thr Ser Lys Phe Leu Arg Gln Tyr Ser His Gly Lys Asp Met Asn 
    130                 135                 140                 


Tyr Ile Ala Lys Ser Ala Val Glu Val Ile Glu Phe Val Lys Ser Lys 
145                 150                 155                 160 


Gly Ile Glu Ile Arg Phe Ser Ser Glu Asp Ser Phe Arg Ser Asp Leu 
                165                 170                 175     


Val Asp Leu Leu Asn Ile Tyr Lys Thr Val Asp Lys Ile Gly Val Asn 
            180                 185                 190         


Arg Val Gly Ile Ala Asp Thr Val Gly Cys Ala Asn Pro Arg Gln Val 
        195                 200                 205             


Tyr Glu Leu Ile Arg Thr Leu Lys Ser Val Val Ser Cys Asp Ile Glu 
    210                 215                 220                 


Cys His Phe His Asn Asp Thr Gly Cys Ala Ile Ala Asn Ala Tyr Thr 
225                 230                 235                 240 


Ala Leu Glu Gly Gly Ala Arg Leu Ile Asp Val Ser Val Leu Gly Ile 
                245                 250                 255     


Gly Glu Arg Asn Gly Ile Thr Pro Leu Gly Gly Leu Met Ala Arg Met 
            260                 265                 270         


Ile Val Ala Ala Pro Asp Tyr Val Arg Ser Lys Tyr Lys Leu His Lys 
        275                 280                 285             


Ile Arg Asp Ile Glu Asn Leu Val Ala Asp Ala Val Glu Val Asn Ile 
    290                 295                 300                 


Pro Phe Asn Asn Pro Ile Thr Gly Phe Cys Ala Phe Thr His Lys Ala 
305                 310                 315                 320 


Gly Ile His Ala Lys Ala Ile Leu Ala Asn Pro Ser Thr Tyr Glu Ile 
                325                 330                 335     


Leu Asp Pro His Asp Phe Gly Met Lys Arg Tyr Ile His Phe Ala Asn 
            340                 345                 350         


Arg Leu Thr Gly Trp Asn Ala Ile Lys Ser Arg Val Asp Gln Leu Asn 
        355                 360                 365             


Leu Asn Leu Thr Asp Asp Gln Ile Lys Glu Val Thr Ala Lys Ile Lys 
    370                 375                 380                 


Lys Leu Gly Asp Val Arg Pro Leu Asn Ile Asp Asp Val Asp Ser Ile 
385                 390                 395                 400 


Ile Lys Asp Phe His Ala Glu Leu Ser Thr Pro Leu Leu Lys Pro Val 
                405                 410                 415     


Asn Lys Gly Thr Asp Asp Asp Asn Ile Asp Ile Ser Asn Gly His Val 
            420                 425                 430         


Ser Lys Lys Ala Lys Val Thr Lys 
        435                 440 


<210>  45
<211>  428
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  45

Met Thr Ala Ala Lys Pro Asn Pro Tyr Ala Ala Lys Pro Gly Asp Tyr 
1               5                   10                  15      


Leu Ser Asn Val Asn Asn Phe Gln Leu Ile Asp Ser Thr Leu Arg Glu 
            20                  25                  30          


Gly Glu Gln Phe Ala Asn Ala Phe Phe Asp Thr Glu Lys Lys Ile Glu 
        35                  40                  45              


Ile Ala Arg Ala Leu Asp Asp Phe Gly Val Asp Tyr Ile Glu Leu Thr 
    50                  55                  60                  


Ser Pro Val Ala Ser Glu Gln Ser Arg Lys Asp Cys Glu Ala Ile Cys 
65                  70                  75                  80  


Lys Leu Gly Leu Lys Ala Lys Ile Leu Thr His Ile Arg Cys His Met 
                85                  90                  95      


Asp Asp Ala Lys Val Ala Val Glu Thr Gly Val Asp Gly Val Asp Val 
            100                 105                 110         


Val Ile Gly Thr Ser Lys Phe Leu Arg Gln Tyr Ser His Gly Lys Asp 
        115                 120                 125             


Met Asn Tyr Ile Ala Lys Ser Ala Val Glu Val Ile Glu Phe Val Lys 
    130                 135                 140                 


Ser Lys Gly Ile Glu Ile Arg Phe Ser Ser Glu Asp Ser Phe Arg Ser 
145                 150                 155                 160 


Asp Leu Val Asp Leu Leu Asn Ile Tyr Lys Thr Val Asp Lys Ile Gly 
                165                 170                 175     


Val Asn Arg Val Gly Ile Ala Asp Thr Val Gly Cys Ala Asn Pro Arg 
            180                 185                 190         


Gln Val Tyr Glu Leu Ile Arg Thr Leu Lys Ser Val Val Ser Cys Asp 
        195                 200                 205             


Ile Glu Cys His Phe His Asn Asp Thr Gly Cys Ala Ile Ala Asn Ala 
    210                 215                 220                 


Tyr Thr Ala Leu Glu Gly Gly Ala Arg Leu Ile Asp Val Ser Val Leu 
225                 230                 235                 240 


Gly Ile Gly Glu Arg Asn Gly Ile Thr Pro Leu Gly Gly Leu Met Ala 
                245                 250                 255     


Arg Met Ile Val Ala Ala Pro Asp Tyr Val Lys Ser Lys Tyr Lys Leu 
            260                 265                 270         


His Lys Ile Arg Asp Ile Glu Asn Leu Val Ala Asp Ala Val Glu Val 
        275                 280                 285             


Asn Ile Pro Phe Asn Asn Pro Ile Thr Gly Phe Cys Ala Phe Thr His 
    290                 295                 300                 


Lys Ala Gly Ile His Ala Lys Ala Ile Leu Ala Asn Pro Ser Thr Tyr 
305                 310                 315                 320 


Glu Ile Leu Asp Pro His Asp Phe Gly Met Lys Arg Tyr Ile His Phe 
                325                 330                 335     


Ala Asn Arg Leu Thr Gly Trp Asn Ala Ile Lys Ala Arg Val Asp Gln 
            340                 345                 350         


Leu Asn Leu Asn Leu Thr Asp Asp Gln Ile Lys Glu Val Thr Ala Lys 
        355                 360                 365             


Ile Lys Lys Leu Gly Asp Val Arg Ser Leu Asn Ile Asp Asp Val Asp 
    370                 375                 380                 


Ser Ile Ile Lys Asn Phe His Ala Glu Val Ser Thr Pro Gln Val Leu 
385                 390                 395                 400 


Ser Ala Lys Lys Asn Lys Lys Asn Asp Ser Asp Val Pro Glu Leu Ala 
                405                 410                 415     


Thr Ile Pro Ala Ala Lys Arg Thr Lys Pro Ser Ala 
            420                 425             


<210>  46
<211>  393
<212>  PRT
<213>  Kluyveromyces lactis

<400>  46

Met Ser Val Asn Ser Asn Pro Tyr Ala Pro Ser Pro Asn Asp Leu Leu 
1               5                   10                  15      


Ser Asn Val Cys Asn Phe Gln Leu Ile Glu Ser Thr Leu Arg Glu Gly 
            20                  25                  30          


Glu Gln Phe Ala Ser Ala Phe Phe Ser Thr Glu Lys Lys Ile Glu Ile 
        35                  40                  45              


Ala Lys Ala Leu Asp Asp Phe Gly Val Asp Tyr Ile Glu Leu Thr Ser 
    50                  55                  60                  


Pro Val Ala Ser Glu Gln Ser Arg Ser Asp Cys Glu Ala Ile Cys Lys 
65                  70                  75                  80  


Leu Gly Leu Lys Ala Lys Ile Leu Thr His Ile Arg Cys His Met Asp 
                85                  90                  95      


Asp Ala Arg Val Ala Val Glu Thr Gly Val Asp Gly Val Asp Val Val 
            100                 105                 110         


Ile Gly Thr Ser Lys Phe Leu Arg Glu Tyr Ser His Gly Lys Asp Met 
        115                 120                 125             


Asn Tyr Ile Ala Lys Ser Ala Ile Glu Val Ile Glu Phe Val Lys Ser 
    130                 135                 140                 


Lys Gly Leu Glu Ile Arg Phe Ser Ser Glu Asp Ser Phe Arg Ser Asp 
145                 150                 155                 160 


Ile Val Asp Leu Leu Asn Ile Tyr Lys Thr Val Asp Lys Ile Gly Val 
                165                 170                 175     


Asn Arg Val Gly Ile Ala Asp Thr Val Gly Cys Ala Asn Pro Arg Gln 
            180                 185                 190         


Val Tyr Glu Leu Val Arg Thr Leu Lys Ser Val Val Ser Cys Asp Ile 
        195                 200                 205             


Glu Cys His Phe His Asp Asp Thr Gly Cys Ala Ile Gly Asn Ser Tyr 
    210                 215                 220                 


Ser Ala Leu Glu Ala Gly Ala Arg Leu Ile Asp Val Ser Val Leu Gly 
225                 230                 235                 240 


Ile Gly Glu Arg Asn Gly Ile Thr Ser Leu Gly Gly Leu Met Ala Arg 
                245                 250                 255     


Met Ile Val Ser Ala Pro Glu Tyr Val Lys Ser Lys Tyr Lys Leu His 
            260                 265                 270         


Lys Leu Arg Asp Leu Glu Asn Leu Val Ala Asp Ala Val Ser Val Asn 
        275                 280                 285             


Val Pro Phe Asn Asn Pro Ile Thr Gly Phe Cys Ala Phe Thr His Lys 
    290                 295                 300                 


Ala Gly Ile His Ala Lys Ala Ile Leu Ala Asn Pro Ser Thr Tyr Glu 
305                 310                 315                 320 


Ile Leu Asn Pro Glu Asp Phe Gly Met Lys Arg Tyr Ile His Phe Ala 
                325                 330                 335     


Asn Arg Leu Thr Gly Trp Asn Ala Ile Lys Ser Arg Val Glu Gln Leu 
            340                 345                 350         


Asn Leu His Leu Ser Asp Asp Gln Ile Lys Glu Val Thr Ser Lys Ile 
        355                 360                 365             


Lys Gln Ile Gly Asp Val Arg Gln Leu Ser Ile Glu Asp Val Asp Thr 
    370                 375                 380                 


Ile Ile Lys Asp Tyr His Ser Glu Leu 
385                 390             


<210>  47
<211>  490
<212>  PRT
<213>  Phanerochaete chrysosporium


<220>
<221>  misc_feature
<222>  (62)..(62)
<223>  Xaa can be any naturally occurring amino acid

<400>  47

Leu Ser Ile Leu Val Ala Ile Gln Lys Leu Glu Pro Cys Cys Lys Met 
1               5                   10                  15      


Cys Pro His Ala Asn Gly Asp Ser Thr Pro Asn Asp Pro Ser Gln Met 
            20                  25                  30          


Val Pro Val Asp Leu Ser Asn Gly Thr Ser His Gln Ala Ser Val Gln 
        35                  40                  45              


Ser Asn Ser Asn Gly His Ala Ala Thr Asn Gly Ala Ala Xaa Asn Pro 
    50                  55                  60                  


Tyr Ala Pro Arg Ala Ser Asp Phe Leu Ser Asn Val Ser Asn Phe Lys 
65                  70                  75                  80  


Ile Ile Glu Ser Thr Leu Arg Glu Gly Glu Gln Phe Ala Asn Ala Phe 
                85                  90                  95      


Phe Asp Thr Lys Thr Lys Ile Ala Ile Ala Lys Ala Leu Asp Ala Phe 
            100                 105                 110         


Gly Val Glu Tyr Ile Glu Leu Thr Ser Pro Ala Ala Ser Glu Gln Ser 
        115                 120                 125             


Arg Arg Asp Cys Glu Ala Ile Cys Lys Leu Gly Leu Lys Ala Lys Ile 
    130                 135                 140                 


Leu Thr His Ile Arg Cys His Met Asp Asp Ala Arg Ile Ala Val Glu 
145                 150                 155                 160 


Thr Gly Val Asp Gly Val Asp Val Val Ile Gly Thr Ser Ser Phe Leu 
                165                 170                 175     


Arg Glu Phe Ser His Gly Lys Asp Met Ala Tyr Ile Thr Lys Thr Ala 
            180                 185                 190         


Ile Glu Val Ile Glu Phe Val Lys Ser Lys Gly Ile Glu Val Arg Phe 
        195                 200                 205             


Ser Ser Glu Asp Ser Phe Arg Ser Asp Leu Val Asp Leu Leu Ser Ile 
    210                 215                 220                 


Tyr Gln Thr Val Asp Lys Ile Gly Val Asn Arg Val Gly Ile Ala Asp 
225                 230                 235                 240 


Thr Val Gly Cys Ala Asn Pro Arg Gln Val Tyr Asp Leu Val Arg Thr 
                245                 250                 255     


Leu Arg Gly Val Val Lys Cys Asp Ile Glu Ile His Leu His Asn Asp 
            260                 265                 270         


Thr Gly Met Ala Ile Ala Asn Ala Tyr Thr Ala Leu Glu Ala Gly Ala 
        275                 280                 285             


Thr His Ile Asp Thr Ser Val Leu Gly Ile Gly Glu Arg Val Gly Ile 
    290                 295                 300                 


Thr Pro Leu Gly Gly Leu Val Ala Cys Leu Tyr Ala Ala Asn Pro Glu 
305                 310                 315                 320 


Tyr Val Lys Ser Lys Tyr Asn Leu Pro Met Leu Arg Glu Ile Glu Asn 
                325                 330                 335     


Leu Val Ala Glu Ala Val Glu Val Asn Ile Pro Phe Met Asn Pro Ile 
            340                 345                 350         


Thr Gly Tyr Cys Ala Phe Thr His Lys Ala Gly Ile His Ala Lys Ala 
        355                 360                 365             


Ile Leu Asn Asn Pro Ser Thr Tyr Glu Ile Leu Lys Pro Glu Asp Phe 
    370                 375                 380                 


Gly Leu Thr Arg Tyr Val Ser Ile Gly His Arg Leu Thr Gly Trp Asn 
385                 390                 395                 400 


Ala Val Lys Ser Arg Val Glu Gln Leu Gly Leu Lys Leu Thr Asp Glu 
                405                 410                 415     


Glu Ile Lys Asp Val Thr Ala Lys Ile Lys Glu Leu Ala Asp Val Arg 
            420                 425                 430         


Thr Gln Ser Met Asp Asp Val Asp Thr Leu Leu Arg Val Tyr His Ser 
        435                 440                 445             


Gly Ile Gln Ser Gly Glu Leu Ala Ala Gly Gln Arg Glu Ala Leu Asp 
    450                 455                 460                 


Arg Leu Leu Arg Lys His Arg Glu Gly Thr Met Ser Arg Glu Pro Ser 
465                 470                 475                 480 


Val Ser Arg Pro Ser Thr Pro Thr Gln Ala 
                485                 490 


<210>  48
<211>  441
<212>  PRT
<213>  Kluyveromyces lactis

<400>  48

Met Ser Ser Asn Gln Asp Phe Gln Pro Val Thr Glu Ser Ala Ser Ser 
1               5                   10                  15      


Val Thr Lys Phe Gln Gln Asn Pro Tyr Gly Pro Asn Pro Ala Asp Tyr 
            20                  25                  30          


Leu Ser Asn Val Asn Asn Tyr Gln Leu Ile Asp Ser Thr Leu Arg Glu 
        35                  40                  45              


Gly Glu Gln Phe Ala Asn Ala Phe Phe Asp Thr Glu Lys Lys Ile Glu 
    50                  55                  60                  


Ile Ala Lys Ala Leu Asp Asp Phe Gly Val Asp Tyr Ile Glu Leu Thr 
65                  70                  75                  80  


Ser Pro Val Ala Ser Glu Gln Ser Arg Arg Asp Cys Glu Ala Ile Cys 
                85                  90                  95      


Lys Leu Gly Leu Lys Ala Lys Ile Leu Thr His Ile Arg Cys His Met 
            100                 105                 110         


Asp Asp Ala Arg Val Ala Val Glu Thr Gly Val Asp Gly Val Asp Val 
        115                 120                 125             


Val Ile Gly Thr Ser Lys Phe Leu Arg Gln Tyr Ser His Gly Lys Asp 
    130                 135                 140                 


Met Asn Tyr Ile Ala Lys Ser Ala Ile Glu Val Ile Glu Phe Val Lys 
145                 150                 155                 160 


Ser Lys Gly Ile Glu Ile Arg Phe Ser Ser Glu Asp Ser Phe Arg Ser 
                165                 170                 175     


Asp Leu Val Asp Leu Leu Asn Ile Tyr Lys Thr Val Asp Lys Ile Gly 
            180                 185                 190         


Val Asn Arg Val Gly Ile Ala Asp Thr Val Gly Cys Ala Asn Pro Arg 
        195                 200                 205             


Gln Val Tyr Glu Leu Val Arg Thr Leu Lys Ser Val Val Ser Cys Asp 
    210                 215                 220                 


Ile Glu Cys His Phe His Asn Asp Thr Gly Cys Ala Ile Ala Asn Ala 
225                 230                 235                 240 


Tyr Thr Ala Leu Glu Gly Gly Ala Arg Leu Ile Asp Val Ala Val Leu 
                245                 250                 255     


Gly Ile Gly Glu Arg Asn Gly Ile Thr Pro Leu Gly Gly Leu Met Ala 
            260                 265                 270         


Arg Met Ile Val Ala Ala Pro Glu Tyr Thr Lys Ser Lys Tyr Lys Leu 
        275                 280                 285             


His Lys Ile Arg Asp Ile Glu Asn Leu Ile Ala Glu Ala Val Glu Val 
    290                 295                 300                 


Asn Ile Pro Phe Asn Asn Pro Ile Thr Gly Phe Cys Ala Phe Thr His 
305                 310                 315                 320 


Lys Ala Gly Ile His Ala Lys Ala Ile Leu Ala Asn Pro Ser Thr Tyr 
                325                 330                 335     


Glu Ile Leu Asp Pro His Asp Phe Gly Met Lys Arg Tyr Ile His Phe 
            340                 345                 350         


Ala Asn Arg Leu Thr Gly Trp Asn Ala Ile Lys Ser Arg Val Asp Gln 
        355                 360                 365             


Leu Asn Leu Asn Leu Thr Asp Asp Gln Val Lys Glu Val Thr Ala Lys 
    370                 375                 380                 


Ile Lys Lys Leu Gly Asp Ile Arg Pro Leu Asn Ile Asp Asp Val Asp 
385                 390                 395                 400 


Ser Ile Ile Lys Asp Phe His Ala Glu Val Ser Thr Pro Gln Leu Arg 
                405                 410                 415     


Ala Val Arg Arg Asp Asp Asn Asp Val Asn Asp Ile Asp Ile Gln Glu 
            420                 425                 430         


Pro Ser Asn Lys Lys Thr Lys Val Glu 
        435                 440     


<210>  49
<211>  418
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  49

Met Ser Val Ser Glu Ala Asn Gly Thr Glu Thr Ile Lys Pro Pro Met 
1               5                   10                  15      


Asn Gly Asn Pro Tyr Gly Pro Asn Pro Ser Asp Phe Leu Ser Arg Val 
            20                  25                  30          


Asn Asn Phe Ser Ile Ile Glu Ser Thr Leu Arg Glu Gly Glu Gln Phe 
        35                  40                  45              


Ala Asn Ala Phe Phe Asp Thr Glu Lys Lys Ile Gln Ile Ala Lys Ala 
    50                  55                  60                  


Leu Asp Asn Phe Gly Val Asp Tyr Ile Glu Leu Thr Ser Pro Val Ala 
65                  70                  75                  80  


Ser Glu Gln Ser Arg Gln Asp Cys Glu Ala Ile Cys Lys Leu Gly Leu 
                85                  90                  95      


Lys Cys Lys Ile Leu Thr His Ile Arg Cys His Met Asp Asp Ala Arg 
            100                 105                 110         


Val Ala Val Glu Thr Gly Val Asp Gly Val Asp Val Val Ile Gly Thr 
        115                 120                 125             


Ser Gln Tyr Leu Arg Lys Tyr Ser His Gly Lys Asp Met Thr Tyr Ile 
    130                 135                 140                 


Ile Asp Ser Ala Thr Glu Val Ile Asn Phe Val Lys Ser Lys Gly Ile 
145                 150                 155                 160 


Glu Val Arg Phe Ser Ser Glu Asp Ser Phe Arg Ser Asp Leu Val Asp 
                165                 170                 175     


Leu Leu Ser Leu Tyr Lys Ala Val Asp Lys Ile Gly Val Asn Arg Val 
            180                 185                 190         


Gly Ile Ala Asp Thr Val Gly Cys Ala Thr Pro Arg Gln Val Tyr Asp 
        195                 200                 205             


Leu Ile Arg Thr Leu Arg Gly Val Val Ser Cys Asp Ile Glu Cys His 
    210                 215                 220                 


Phe His Asn Asp Thr Gly Met Ala Ile Ala Asn Ala Tyr Cys Ala Leu 
225                 230                 235                 240 


Glu Ala Gly Ala Thr His Ile Asp Thr Ser Ile Leu Gly Ile Gly Glu 
                245                 250                 255     


Arg Asn Gly Ile Thr Pro Leu Gly Ala Leu Leu Ala Arg Met Tyr Val 
            260                 265                 270         


Thr Asp Arg Glu Tyr Ile Thr His Lys Tyr Lys Leu Asn Gln Leu Arg 
        275                 280                 285             


Glu Leu Glu Asn Leu Val Ala Asp Ala Val Glu Val Gln Ile Pro Phe 
    290                 295                 300                 


Asn Asn Tyr Ile Thr Gly Met Cys Ala Phe Thr His Lys Ala Gly Ile 
305                 310                 315                 320 


His Ala Lys Ala Ile Leu Ala Asn Pro Ser Thr Tyr Glu Ile Leu Lys 
                325                 330                 335     


Pro Glu Asp Phe Gly Met Ser Arg Tyr Val His Val Gly Ser Arg Leu 
            340                 345                 350         


Thr Gly Trp Asn Ala Ile Lys Ser Arg Ala Glu Gln Leu Asn Leu His 
        355                 360                 365             


Leu Thr Asp Ala Gln Ala Lys Glu Leu Thr Val Arg Ile Lys Lys Leu 
    370                 375                 380                 


Ala Asp Val Arg Thr Leu Ala Met Asp Asp Val Asp Arg Val Leu Arg 
385                 390                 395                 400 


Glu Tyr His Ala Asp Leu Ser Asp Ala Asp Arg Ile Thr Lys Glu Ala 
                405                 410                 415     


Ser Ala 
        


<210>  50
<211>  465
<212>  PRT
<213>  Aspergillus niger

<400>  50

Met Cys Pro Gly Ala Asp His Glu Pro Asn Gly Gln Ala Asn Val Ala 
1               5                   10                  15      


Asn Gly Asn Gly Asn Asn Gly Glu His Pro Gly Phe Thr Ala Val Glu 
            20                  25                  30          


Thr Arg Gln Asn Pro His Pro Ser Val Ser Arg Asn Pro Tyr Gly His 
        35                  40                  45              


Asn Val Gly Val Thr Asp Phe Leu Ser Asn Val Ser Arg Phe Gln Ile 
    50                  55                  60                  


Ile Glu Ser Thr Leu Arg Glu Gly Glu Gln Phe Ala Asn Ala Phe Phe 
65                  70                  75                  80  


Asp Thr Glu Lys Lys Ile Glu Ile Ala Lys Ala Leu Asp Glu Phe Gly 
                85                  90                  95      


Val Asp Tyr Ile Glu Leu Thr Ser Pro Cys Ala Ser Glu Gln Ser Arg 
            100                 105                 110         


Lys Asp Cys Glu Ala Ile Cys Lys Leu Gly Leu Lys Ala Lys Ile Leu 
        115                 120                 125             


Thr His Ile Arg Cys His Met Asp Asp Ala Arg Ile Ala Val Glu Thr 
    130                 135                 140                 


Gly Val Asp Gly Val Asp Val Val Ile Gly Thr Ser Ser Tyr Leu Arg 
145                 150                 155                 160 


Glu His Ser His Gly Lys Asp Met Thr Tyr Ile Lys Asn Thr Ala Ile 
                165                 170                 175     


Glu Val Ile Glu Phe Val Lys Ser Lys Gly Ile Glu Ile Arg Phe Ser 
            180                 185                 190         


Ser Glu Asp Ser Phe Arg Ser Asp Leu Val Asp Leu Leu Ser Ile Tyr 
        195                 200                 205             


Ser Ala Val Asp Lys Val Gly Val Asn Arg Val Gly Ile Ala Asp Thr 
    210                 215                 220                 


Val Gly Cys Ala Ser Pro Arg Gln Val Tyr Glu Leu Val Arg Val Leu 
225                 230                 235                 240 


Arg Gly Val Val Ser Cys Asp Ile Glu Thr His Phe His Asn Asp Thr 
                245                 250                 255     


Gly Cys Ala Ile Ala Asn Ala Tyr Cys Ala Leu Glu Ala Gly Ala Thr 
            260                 265                 270         


His Ile Asp Thr Ser Val Leu Gly Ile Gly Glu Arg Asn Gly Ile Thr 
        275                 280                 285             


Pro Leu Gly Gly Leu Met Ala Arg Met Met Val Ala Asp Pro Glu Tyr 
    290                 295                 300                 


Val Lys Ser Lys Tyr Arg Leu Glu Lys Leu Lys Asp Ile Glu Asp Leu 
305                 310                 315                 320 


Val Ala Glu Ala Val Glu Val Asn Ile Pro Phe Asn Asn Tyr Ile Thr 
                325                 330                 335     


Gly Phe Cys Ala Phe Thr His Lys Ala Gly Ile His Ala Lys Ala Ile 
            340                 345                 350         


Leu Asn Asn Pro Ser Thr Tyr Glu Ile Ile Asn Pro Ala Asp Phe Gly 
        355                 360                 365             


Met Ser Arg Tyr Val His Phe Ala Ser Arg Leu Thr Gly Trp Asn Ala 
    370                 375                 380                 


Ile Lys Ser Arg Ala Gln Gln Leu Lys Ile Glu Met Thr Asp Asp Gln 
385                 390                 395                 400 


Tyr Lys Glu Cys Thr Ala Lys Ile Lys Ala Leu Ala Asp Ile Arg Pro 
                405                 410                 415     


Ile Ala Val Asp Asp Ala Asp Ser Ile Ile Arg Ala Tyr Tyr Arg Asn 
            420                 425                 430         


Leu Lys Leu Gly Glu Asn Lys Pro Leu Leu Asp Leu Thr Ala Asp Glu 
        435                 440                 445             


Gln Ala Gln Phe Ala Ala Lys Glu Lys Glu Leu Ala Ala Gln Ala Ser 
    450                 455                 460                 


Ala 
465 


<210>  51
<211>  445
<212>  PRT
<213>  Emericella nidulans

<400>  51

Met Cys Pro Gly Asp His Pro Gly Phe Thr Ala Val Gln Thr Arg Gln 
1               5                   10                  15      


Asn Pro His Pro Ser Arg Asn Pro Tyr Gly His Asn Val Gly Val Thr 
            20                  25                  30          


Asp Phe Leu Ser Asn Val Ser Arg Phe Lys Ile Ile Glu Ser Thr Leu 
        35                  40                  45              


Arg Glu Gly Glu Gln Phe Ala Asn Ala Phe Phe Asp Thr Gln Lys Lys 
    50                  55                  60                  


Ile Glu Ile Ala Lys Ala Leu Asp Glu Phe Gly Val Asp Tyr Ile Glu 
65                  70                  75                  80  


Leu Thr Ser Pro Cys Ala Ser Glu Gln Ser Arg Leu Asp Cys Glu Ala 
                85                  90                  95      


Ile Cys Lys Leu Gly Leu Lys Ala Lys Ile Leu Thr His Ile Arg Cys 
            100                 105                 110         


His Met Asp Asp Ala Arg Val Ala Val Glu Thr Gly Val Asp Gly Val 
        115                 120                 125             


Asp Val Val Ile Gly Thr Ser Ser Tyr Leu Arg Glu His Ser His Gly 
    130                 135                 140                 


Lys Asp Met Thr Tyr Ile Lys Asn Thr Ala Ile Glu Val Ile Glu Phe 
145                 150                 155                 160 


Val Lys Ser Lys Gly Ile Glu Ile Arg Phe Ser Ser Glu Asp Ser Phe 
                165                 170                 175     


Arg Ser Asp Leu Val Asp Leu Leu Ser Ile Tyr Ser Ala Val Asp Gln 
            180                 185                 190         


Val Gly Val Asn Arg Val Gly Ile Ala Asp Thr Val Gly Cys Ala Ser 
        195                 200                 205             


Pro Arg Gln Val Tyr Glu Leu Ile Arg Val Leu Arg Gly Val Val Ser 
    210                 215                 220                 


Cys Asp Ile Glu Thr His Phe His Asn Asp Thr Gly Cys Ala Ile Ala 
225                 230                 235                 240 


Asn Ala Tyr Cys Ala Leu Glu Ala Gly Ala Thr His Ile Asp Thr Ser 
                245                 250                 255     


Val Leu Gly Ile Gly Glu Arg Asn Gly Ile Thr Pro Leu Gly Gly Leu 
            260                 265                 270         


Met Ala Arg Met Met Val Ala Asp Pro Gln Tyr Val Lys Ser Lys Tyr 
        275                 280                 285             


Lys Leu Glu Lys Leu Lys Asp Ile Glu Asp Leu Val Ala Glu Ala Val 
    290                 295                 300                 


Glu Val Asn Ile Pro Phe Asn Asn Tyr Ile Thr Gly Phe Cys Ala Phe 
305                 310                 315                 320 


Thr His Lys Ala Gly Ile His Ala Lys Ala Ile Leu Asn Asn Pro Ser 
                325                 330                 335     


Thr Tyr Glu Ile Ile Asn Pro Ala Asp Phe Gly Met Ser Arg Tyr Val 
            340                 345                 350         


His Phe Ala Ser Arg Leu Thr Gly Trp Asn Ala Ile Lys Ser Arg Ala 
        355                 360                 365             


Gln Gln Leu Asn Val His Met Thr Asp Asp Gln Tyr Lys Glu Cys Thr 
    370                 375                 380                 


Ala Lys Ile Lys Ala Leu Ala Asp Ile Arg Pro Ile Ala Ile Asp Asp 
385                 390                 395                 400 


Ala Asp Ser Ile Ile Arg Ala Tyr Tyr Arg Asn Leu Ser Ser Gly Glu 
                405                 410                 415     


Asn Lys Pro Leu Met Asp Leu Thr Ala Asp Glu His Ala Gln Phe Leu 
            420                 425                 430         


Ala Lys Glu Lys Glu Leu Thr Glu Ser Gly Thr Ala Leu 
        435                 440                 445 


<210>  52
<211>  474
<212>  PRT
<213>  Penicillium chrysogenum

<400>  52

Met Val Leu Leu Pro Pro Ser Leu Pro Val Cys Gln Leu Lys Val Thr 
1               5                   10                  15      


Ala Pro Glu Phe Pro Ser Asn Phe Tyr Leu Asp Gly Asp His Ser Gly 
            20                  25                  30          


Phe Val Gly Ile Glu Thr Arg Gln Asn Pro His Pro Ser Ala Ser Arg 
        35                  40                  45              


Asn Pro Tyr Gly His Asp Ala Gly Val Thr Asp Phe Leu Ser Asn Val 
    50                  55                  60                  


Ser Arg Phe Gln Ile Ile Glu Ser Thr Leu Arg Glu Gly Glu Gln Phe 
65                  70                  75                  80  


Ala Asn Ala Phe Phe Asp Thr Ala Lys Lys Ile Glu Ile Ala Lys Ala 
                85                  90                  95      


Leu Asp Asp Phe Gly Val Asp Tyr Ile Glu Leu Thr Ser Pro Cys Ala 
            100                 105                 110         


Ser Glu Gln Ser Arg Ala Asp Cys Glu Ala Ile Cys Lys Leu Gly Leu 
        115                 120                 125             


Lys Ala Lys Ile Leu Thr His Ile Arg Cys His Met Asp Asp Ala Arg 
    130                 135                 140                 


Ile Ala Val Glu Thr Gly Val Asp Gly Val Asp Val Val Ile Gly Thr 
145                 150                 155                 160 


Ser Ser Tyr Leu Arg Glu His Ser His Gly Lys Asp Met Thr Tyr Ile 
                165                 170                 175     


Lys Asn Ala Ala Ile Glu Val Ile Glu Phe Val Lys Ser Lys Gly Ile 
            180                 185                 190         


Glu Ile Arg Phe Ser Ser Glu Asp Ser Phe Arg Ser Asp Leu Val Asp 
        195                 200                 205             


Leu Leu Ser Ile Tyr Ser Ala Val Asp Lys Val Gly Val Asn Arg Val 
    210                 215                 220                 


Gly Ile Ala Asp Thr Val Gly Cys Ala Ser Pro Arg Gln Val Tyr Glu 
225                 230                 235                 240 


Leu Val Arg Val Leu Arg Gly Val Val Gly Cys Asp Ile Glu Thr His 
                245                 250                 255     


Phe His Asn Asp Thr Gly Cys Ala Ile Ala Asn Ala Phe Cys Ala Leu 
            260                 265                 270         


Glu Ala Gly Ala Thr His Ile Asp Thr Ser Val Leu Gly Ile Gly Glu 
        275                 280                 285             


Arg Asn Gly Ile Thr Pro Leu Gly Gly Leu Met Ala Arg Met Met Val 
    290                 295                 300                 


Ala Asp Arg Glu Tyr Val Lys Ser Lys Tyr Lys Leu Glu Lys Leu Lys 
305                 310                 315                 320 


Glu Ile Glu Asp Leu Val Ala Glu Ala Val Glu Val Asn Ile Pro Phe 
                325                 330                 335     


Asn Asn Tyr Ile Thr Gly Phe Cys Ala Phe Thr His Lys Ala Gly Ile 
            340                 345                 350         


His Ala Lys Ala Ile Leu Asn Asn Pro Ser Thr Tyr Glu Ile Ile Asn 
        355                 360                 365             


Pro Ala Asp Phe Gly Met Ser Arg Tyr Val His Phe Ala Ser Arg Leu 
    370                 375                 380                 


Thr Gly Trp Asn Ala Ile Lys Ser Arg Ala Gln Gln Leu Lys Leu Glu 
385                 390                 395                 400 


Met Thr Asp Thr Gln Tyr Lys Glu Cys Thr Ala Lys Ile Lys Ala Met 
                405                 410                 415     


Ala Asp Ile Arg Pro Ile Ala Val Asp Asp Ala Asp Ser Ile Ile Arg 
            420                 425                 430         


Ala Tyr His Arg Asn Leu Lys Ser Gly Glu Asn Lys Pro Leu Leu Asp 
        435                 440                 445             


Leu Thr Ala Glu Glu Gln Ala Ala Phe Ala Ala Lys Glu Lys Glu Leu 
    450                 455                 460                 


Leu Glu Ala Gln Ala Ala Gly Leu Pro Val 
465                 470                 


<210>  53
<211>  446
<212>  PRT
<213>  Yarrowia lipolytica

<400>  53

Met Cys Ala Thr Asp Asn Ala Pro Ala Ala Asn Ala Ala Pro Glu Lys 
1               5                   10                  15      


Pro Ser Asn Val Gly Val Glu Val Gly His Thr Gly Glu Gln Thr Asn 
            20                  25                  30          


Pro Tyr Gly Ala Asn Pro Ala Asp Phe Leu Ser Asn Val Ser Lys Phe 
        35                  40                  45              


Gln Leu Ile Glu Ser Thr Leu Arg Glu Gly Glu Gln Phe Ala Ser Ala 
    50                  55                  60                  


Phe Phe Asp Thr Glu Thr Lys Ile Glu Ile Ala Lys Ala Leu Asp Asp 
65                  70                  75                  80  


Phe Gly Val Asp Tyr Ile Glu Leu Thr Ser Pro Ala Ala Ser Glu Gln 
                85                  90                  95      


Ser Arg Ser Asp Cys Glu Ala Ile Cys Lys Leu Gly Leu Lys Ala Lys 
            100                 105                 110         


Ile Leu Thr His Ile Arg Cys His Met Asp Asp Ala Arg Leu Ala Val 
        115                 120                 125             


Ser Thr Gly Val Asp Gly Val Asp Val Val Ile Gly Thr Ser Gln Phe 
    130                 135                 140                 


Leu Arg Gln Tyr Ser His Gly Lys Asp Met Asn Tyr Ile Ala Gln Ser 
145                 150                 155                 160 


Ala Val Glu Val Ile Glu Phe Val Lys Ser His Gly Ile Glu Ile Arg 
                165                 170                 175     


Phe Ser Ser Glu Asp Ser Phe Arg Ser Asp Leu Val Asp Leu Leu Asn 
            180                 185                 190         


Ile Tyr Arg Thr Val Asp Lys Ile Gly Val Asn Arg Val Gly Ile Ala 
        195                 200                 205             


Asp Thr Val Gly Cys Ala Asn Pro Arg Gln Val Tyr Glu Leu Val Arg 
    210                 215                 220                 


Thr Leu Lys Ser Val Val Ser Cys Asp Ile Glu Cys His Phe His Asn 
225                 230                 235                 240 


Asp Thr Gly Cys Ala Ile Ala Asn Ala Tyr Thr Ala Leu Glu Ala Gly 
                245                 250                 255     


Ala Asn Leu Ile Asp Val Ser Val Leu Gly Ile Gly Glu Arg Asn Gly 
            260                 265                 270         


Ile Thr Ser Leu Gly Gly Leu Met Ala Arg Met Ile Ala Ala Asp Arg 
        275                 280                 285             


Asp Tyr Val Leu Ser Lys Tyr Lys Leu His Lys Leu Arg Asp Leu Glu 
    290                 295                 300                 


Asn Leu Val Ala Asp Ala Val Gln Val Asn Ile Pro Phe Asn Asn Pro 
305                 310                 315                 320 


Ile Thr Gly Phe Cys Ala Phe Thr His Lys Ala Gly Ile His Ala Lys 
                325                 330                 335     


Ala Ile Leu Ala Asn Pro Ser Thr Tyr Glu Ile Leu Asn Pro Ala Asp 
            340                 345                 350         


Phe Gly Leu Thr Arg Tyr Ile His Phe Ala Asn Arg Leu Thr Gly Trp 
        355                 360                 365             


Asn Ala Ile Lys Ser Arg Val Asp Gln Leu Asn Leu His Leu Thr Asp 
    370                 375                 380                 


Ala Gln Cys Lys Asp Val Thr Ala Lys Ile Lys Lys Leu Gly Asp Val 
385                 390                 395                 400 


Arg Ser Leu Asn Ile Asp Asp Val Asp Ser Ile Ile Arg Glu Phe His 
                405                 410                 415     


Ala Asp Val Thr Ser Thr Pro Thr Val Ala Ala Thr Glu Gly Pro Ala 
            420                 425                 430         


Val Glu Asp Glu Pro Ala Ala Lys Lys Ala Lys Thr Glu Glu 
        435                 440                 445     


<210>  54
<211>  687
<212>  PRT
<213>  Phanerochaete chrysosporium

<400>  54

Ile Pro Gln Thr Val Ile Glu Lys Val Val Gln Lys Tyr Ala Val Gly 
1               5                   10                  15      


Leu Pro Gly Asp Lys Val Val Lys Ala Gly Asp Tyr Val Met Ile Arg 
            20                  25                  30          


Pro Glu His Val Met Thr His Asp Asn Thr Gly Pro Val Ile Ser Lys 
        35                  40                  45              


Phe Lys Ser Ile Gly Ala Thr Arg Ile Tyr Asn Pro Lys Gln Val Val 
    50                  55                  60                  


Phe Thr Leu Asp His Asp Val Gln Asn Lys Ser Glu Lys Asn Leu Lys 
65                  70                  75                  80  


Lys Tyr Ala Thr Ile Glu Ala Phe Ala Arg Thr His Gly Ile Asp Phe 
                85                  90                  95      


Tyr Pro Ala Gly Arg Gly Ile Gly His Gln Val Leu Val Glu Glu Gly 
            100                 105                 110         


Tyr Ala Phe Pro His Thr Leu Thr Val Ala Ser Asp Ser His Ser Asn 
        115                 120                 125             


Met Tyr Gly Gly Val Gly Cys Val Gly Thr Pro Ile Val Arg Thr Asp 
    130                 135                 140                 


Ala Ala Ala Leu Trp Ala Thr Gly Gln Thr Trp Trp Gln Val Pro Arg 
145                 150                 155                 160 


Met Val Lys Val Glu Phe Lys Gly Arg Leu Ala Pro Gly Val Ser Gly 
                165                 170                 175     


Lys Asp Val Ile Val Ala Leu Cys Gly Ser Phe Asn Lys Asp Glu Val 
            180                 185                 190         


Leu Asn Ala Ala Ile Glu Phe Ser Gly Glu Gly Val Gln His Leu Thr 
        195                 200                 205             


Val Asp Glu Arg Leu Thr Ile Ala Asn Met Thr Thr Glu Trp Gly Ala 
    210                 215                 220                 


Leu Val Gly Val Phe Pro Val Asp Asp Val Thr Leu Ser Trp Tyr Glu 
225                 230                 235                 240 


Arg Met Leu Lys Lys Leu Glu Leu Arg Thr Phe Ser Thr Pro Ala Leu 
                245                 250                 255     


Gly Ser Ser Ile Pro Pro Pro Pro Glu His Pro Arg Ile Asn Arg Ala 
            260                 265                 270         


Arg Leu Asp Ala Leu Arg Ala Asn Asn Leu Arg Ser Asp Ala Asp Ala 
        275                 280                 285             


Glu Tyr Ser Ser His Leu Val Phe Asp Leu Ser Thr Leu Val Pro Tyr 
    290                 295                 300                 


Val Ser Gly Pro Asn Ser Val Lys Val Ala Asn Pro Leu Pro Lys Leu 
305                 310                 315                 320 


Glu Glu Ala Lys Ile Lys Ile Asn Lys Ala Tyr Leu Leu Ser Cys Thr 
                325                 330                 335     


Asn Ala Arg Ala Ser Asp Ile Ala Ala Ala Ala Ala Val Ile Lys Gly 
            340                 345                 350         


His Lys Val His Pro Asp Val Gln Phe Tyr Phe Ala Pro Ala Ser Ser 
        355                 360                 365             


Glu Val Gln Arg Glu Ala Glu Gln Ser Gly Asp Trp Glu Thr Leu Ile 
    370                 375                 380                 


Gly Ala Gly Ala Lys Pro Leu Pro Ala Gly Cys Gly Pro Cys Ile Gly 
385                 390                 395                 400 


Leu Gly Thr Gly Leu Leu Glu Glu Gly Glu Val Gly Ile Ser Ala Thr 
                405                 410                 415     


Asn Arg Asn Tyr Lys Gly Arg Met Gly His Pro Leu Ala Gln Ala Tyr 
            420                 425                 430         


Leu Ala Ser Pro Ala Val Val Ala Ala Ser Ala Ile Lys Gly Tyr Ile 
        435                 440                 445             


Ala Gly Pro Asp Ser Leu Asp Pro Ser Lys Leu Pro Pro Ala Gly Ala 
    450                 455                 460                 


Pro Thr Phe Ser Ile Val Asn Ser Pro Ser Ser Gly Ala Lys Ala Ser 
465                 470                 475                 480 


Gln Lys Glu Pro Val Leu Val Gly Phe Pro Glu Thr Phe Ala Gly Pro 
                485                 490                 495     


Leu Leu Phe Ala Pro Gln Asp Asn Leu Asn Thr Asp Gly Ile Tyr Pro 
            500                 505                 510         


Gly Lys Tyr Thr Tyr Gln Asp Asp Ile Thr Leu Glu Arg Gln Ala Glu 
        515                 520                 525             


Val Val Met Glu Asn Tyr Asp Pro Thr Phe Ala Gln Leu Asp Ala His 
    530                 535                 540                 


Thr Lys Arg Gly Val Val Leu Val Ser Gly Tyr Asn Phe Gly Thr Gly 
545                 550                 555                 560 


Ser Ser Arg Glu Gln Ala Ala Thr Ala Leu Lys Ser Ala Gly Ile Pro 
                565                 570                 575     


Ile Val Ile Ala Gly Ser Phe Gly Asp Ile Phe Lys Arg Asn Ala Ile 
            580                 585                 590         


Asn Asn Gly Leu Val Cys Val Glu Ser Pro Glu Leu Val Ala Asp Leu 
        595                 600                 605             


Thr Ala Gln Phe Ala Lys Asp Gly Lys Arg Gly Ala Gly Gly Lys Glu 
    610                 615                 620                 


Gly Glu Leu Thr Val Asn Lys Gly Leu Ser Ala Glu Val Lys Val Val 
625                 630                 635                 640 


Asp Gly Ala Leu His Val Thr Phe Pro Asp Gly Lys Thr Lys Thr Tyr 
                645                 650                 655     


Thr Ile Gln Pro Val Gly Ala Ser Val Gln Glu Leu Trp Leu Cys Gly 
            660                 665                 670         


Gly Leu Glu Gly Tyr Val Leu Lys Ala Ile Gln Ala Glu Asn Phe 
        675                 680                 685         


<210>  55
<211>  721
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  55

Met Asp Ser Gly Glu Met His His Pro Tyr Gln Ala Phe Ser Lys Val 
1               5                   10                  15      


Gly Lys Cys Glu Ile Ser Gln Thr Asn Pro Ser Phe Ser Ser Gly Met 
            20                  25                  30          


Arg Cys Leu Val Arg Ser Ala Asp Ile Gln Phe Lys Gly Ile Cys Gly 
        35                  40                  45              


Leu Thr Arg Gly Phe Ala Ser Phe Asn Lys Pro Pro Gln Thr Ile Thr 
    50                  55                  60                  


Glu Lys Ile Val Gln Lys Phe Ala Gln Asn Ile Pro Glu Asn Lys Tyr 
65                  70                  75                  80  


Val Arg Ser Gly Asp Tyr Val Thr Ile Lys Pro Lys His Cys Met Ser 
                85                  90                  95      


His Asp Asn Ser Trp Pro Val Ala Leu Lys Phe Met Gly Ile Gly Ala 
            100                 105                 110         


Lys Lys Val Phe Asp Asn Arg Gln Ile Val Cys Thr Leu Asp His Asp 
        115                 120                 125             


Val Gln Asn Lys Ser Glu Ala Asn Leu Arg Lys Tyr Lys Asn Ile Glu 
    130                 135                 140                 


Ser Phe Ala Lys Gly Gln Gly Ile Asp Phe Tyr Pro Ala Gly Arg Gly 
145                 150                 155                 160 


Ile Gly His Gln Ile Met Val Glu Gln Gly Tyr Ala Met Pro Gly Ser 
                165                 170                 175     


Met Ala Val Ala Ser Asp Ser His Ser Asn Thr Tyr Gly Gly Val Gly 
            180                 185                 190         


Cys Leu Gly Thr Pro Ile Val Arg Thr Asp Ala Ala Ala Ile Trp Ala 
        195                 200                 205             


Thr Gly Gln Thr Trp Trp Gln Ile Pro Pro Ile Ala Arg Val Asn Leu 
    210                 215                 220                 


Val Gly Gln Leu Pro Lys Gly Leu Ser Gly Lys Asp Ile Ile Val Ser 
225                 230                 235                 240 


Leu Cys Gly Ala Phe Asn His Asp Glu Val Leu Asn His Ala Ile Glu 
                245                 250                 255     


Phe Tyr Gly Glu Gly Leu Asn Ser Leu Ser Ile Glu Ser Arg Leu Thr 
            260                 265                 270         


Ile Ala Asn Met Thr Thr Glu Trp Gly Ala Leu Ser Gly Leu Phe Pro 
        275                 280                 285             


Thr Asp Glu Lys Leu Leu Ala Trp Tyr Glu Asp Arg Leu Lys Phe Leu 
    290                 295                 300                 


Gly Pro Asn His Pro Arg Val Asn Arg Glu Thr Leu Asp Ala Ile Lys 
305                 310                 315                 320 


Ala Ser Pro Ile Leu Ala Asp Glu Gly Ala Phe Tyr Ala Lys His Leu 
                325                 330                 335     


Ile Leu Asp Leu Ser Thr Leu Ser Pro Ala Val Ser Gly Pro Asn Ser 
            340                 345                 350         


Val Lys Val Tyr Asn Ser Ala Ala Thr Leu Glu Lys Lys Asp Ile Leu 
        355                 360                 365             


Ile Lys Lys Ala Tyr Leu Val Ser Cys Thr Asn Gly Arg Leu Ser Asp 
    370                 375                 380                 


Ile His Asp Ala Ala Glu Thr Val Lys Gly Lys Lys Val Ala Asp Gly 
385                 390                 395                 400 


Val Glu Phe Tyr Val Gly Ala Ala Ser Ser Glu Val Glu Ala Ala Ala 
                405                 410                 415     


Gln Lys Asn Gly Asp Trp Gln Thr Leu Ile Asp Ser Gly Ala Arg Thr 
            420                 425                 430         


Leu Pro Ala Gly Cys Gly Pro Cys Ile Gly Leu Gly Thr Gly Leu Leu 
        435                 440                 445             


Lys Asp Gly Glu Val Gly Ile Ser Ala Thr Asn Arg Asn Phe Lys Gly 
    450                 455                 460                 


Arg Met Gly Ser Arg Glu Ala Leu Ala Tyr Leu Ala Ser Pro Ala Val 
465                 470                 475                 480 


Val Ala Ala Ser Ala Ile Ala Gly Lys Ile Val Ala Pro Glu Gly Phe 
                485                 490                 495     


Lys Asn Ala Val Ser Leu Val Ser Ala Val Asp Ile Thr Asp Lys Val 
            500                 505                 510         


Asn Lys Gln Thr Ala Ser Lys Ser Ser Thr Glu Ala Val Asp Ser Glu 
        515                 520                 525             


Thr Ala Ile Ile Asp Gly Phe Pro Ser Ile Val Ala Gly Glu Ile Val 
    530                 535                 540                 


Phe Cys Asp Ala Asp Asn Leu Asn Thr Asp Gly Ile Tyr Pro Gly Arg 
545                 550                 555                 560 


Tyr Thr Tyr Arg Asp Asp Ile Thr Lys Glu Glu Met Ala Lys Val Cys 
                565                 570                 575     


Met Glu Asn Tyr Asp Ser Glu Phe Gly Lys Lys Thr Lys Lys Asp Asp 
            580                 585                 590         


Ile Leu Val Ser Gly Phe Asn Phe Gly Thr Gly Ser Ser Arg Glu Gln 
        595                 600                 605             


Ala Ala Thr Ala Ile Leu Ser Arg Gly Ile Pro Leu Val Val Gly Gly 
    610                 615                 620                 


Ser Phe Ser Asp Ile Phe Lys Arg Asn Ser Ile Asn Asn Ala Leu Leu 
625                 630                 635                 640 


Ala Ile Gln Leu Pro Asp Leu Val Gln Lys Leu Arg Thr Ala Phe Ala 
                645                 650                 655     


Asn Glu Ser Lys Glu Leu Thr Arg Arg Thr Gly Trp His Leu Lys Trp 
            660                 665                 670         


Asp Val Arg Lys Ser Thr Val Thr Val Thr Thr Ser Asp Asn Lys Glu 
        675                 680                 685             


Met Ser Trp Lys Ile Gly Glu Leu Gly Asn Ser Val Gln Ser Leu Phe 
    690                 695                 700                 


Val Arg Gly Gly Leu Glu Gly Trp Val Lys His Glu Ile Ser Lys Ser 
705                 710                 715                 720 


Asn 
    


<210>  56
<211>  693
<212>  PRT
<213>  Kluyveromyces lactis

<400>  56

Met Phe Arg Val Gln Arg Leu Arg Met Phe Ser Thr Ser Arg Ala Leu 
1               5                   10                  15      


Tyr Ala Gly Gln Asn Met Thr Glu Lys Ile Val Gln Arg His Ala Val 
            20                  25                  30          


Gly Leu Pro Glu Gly Lys Thr Val Val Ser Gly Asp Tyr Val Ser Ile 
        35                  40                  45              


Lys Pro Ala His Cys Met Ser His Asp Asn Ser Trp Pro Val Ala Leu 
    50                  55                  60                  


Lys Phe Met Gly Leu Gly Ala Ser Thr Ile Lys Asn Pro Arg Gln Val 
65                  70                  75                  80  


Val Asn Thr Leu Asp His Asp Val Gln Asn Lys Ser Glu Lys Asn Leu 
                85                  90                  95      


Thr Lys Tyr Lys Asn Ile Glu Asn Phe Ala Lys Lys His Gly Ile Asp 
            100                 105                 110         


Phe Tyr Pro Ala Gly Arg Gly Ile Gly His Gln Ile Met Ile Glu Glu 
        115                 120                 125             


Gly Tyr Ala Phe Pro Leu Thr Met Thr Val Ala Ser Asp Ser His Ser 
    130                 135                 140                 


Asn Thr Tyr Gly Gly Ile Gly Ala Leu Gly Thr Pro Ile Val Arg Thr 
145                 150                 155                 160 


Asp Ala Ala Ala Ile Trp Ala Thr Gly Gln Thr Trp Trp Gln Ile Pro 
                165                 170                 175     


Pro Val Ala Gln Val Glu Leu Lys Gly Glu Leu Pro Ala Gly Ile Ser 
            180                 185                 190         


Gly Lys Asp Ile Ile Val Ala Leu Cys Gly Val Phe Asn Gln Asp Gln 
        195                 200                 205             


Val Leu Asn His Ala Ile Glu Phe Thr Gly Asp Ser Leu Asp Lys Ile 
    210                 215                 220                 


Pro Ile Asp Tyr Arg Leu Thr Ile Ala Asn Met Thr Thr Glu Trp Gly 
225                 230                 235                 240 


Ala Leu Ser Gly Leu Phe Pro Val Asp Asn Val Leu Leu Asp Phe Tyr 
                245                 250                 255     


Arg Asn Arg Leu Thr Lys Val Gly Asn Asn His Pro Arg Ile Asn Glu 
            260                 265                 270         


Ala Arg Ile Asn Glu Leu Gln Ala Lys Ser Asp Ser Leu Gln Ala Asp 
        275                 280                 285             


Pro Asp Ala Lys Tyr Ala Lys Lys Leu Ile Ile Asp Leu Ser Thr Leu 
    290                 295                 300                 


Thr His Tyr Val Ser Gly Pro Asn Ser Val Lys Ile Ser Ser Thr Val 
305                 310                 315                 320 


Asp Asp Leu Ser Lys Gln Asp Ile Lys Val Asn Lys Ala Tyr Leu Val 
                325                 330                 335     


Ser Cys Thr Asn Ser Arg Leu Ser Asp Leu Glu Ser Ala Ala Asn Val 
            340                 345                 350         


Val Cys Pro Ser Gly Asp Ile Asn Gln Val His Lys Val Ala Glu Gly 
        355                 360                 365             


Val Glu Phe Tyr Ile Ala Ala Ala Ser Ser Glu Val Glu Ala Glu Ala 
    370                 375                 380                 


Arg Ala Thr Gly Ala Trp Gln Lys Leu Leu Asn Ala Gly Cys Leu Pro 
385                 390                 395                 400 


Leu Pro Ala Gly Cys Gly Pro Cys Ile Gly Leu Gly Thr Gly Leu Leu 
                405                 410                 415     


Glu Glu Gly Gln Val Gly Ile Ser Ala Thr Asn Arg Asn Phe Lys Gly 
            420                 425                 430         


Arg Met Gly Ser Lys Asp Ala Leu Ala Tyr Leu Ala Ser Pro Ser Val 
        435                 440                 445             


Val Ala Ala Ser Ala Ile Leu Gly Lys Ile Gly Ser Pro Ala Glu Val 
    450                 455                 460                 


Leu Gly Thr Lys Asp Pro Asn Phe Thr Gly Val Val Ala Thr Val Glu 
465                 470                 475                 480 


Asp Ala Pro Ala Thr Ser Ala Asp Gly Lys Asp Val Ala Asp Glu Ser 
                485                 490                 495     


Gly Ala Ser Gly Ser Val Glu Ile Leu Glu Gly Phe Pro Ser Glu Ile 
            500                 505                 510         


Ser Gly Glu Leu Val Leu Cys Asp Ala Asp Asn Ile Asn Thr Asp Gly 
        515                 520                 525             


Ile Tyr Pro Gly Lys Tyr Thr Tyr Gln Asp Asp Val Pro Lys Glu Thr 
    530                 535                 540                 


Met Ala Lys Val Cys Met Glu Asn Tyr Asp Pro Asp Phe Gln Thr Lys 
545                 550                 555                 560 


Ala Asn Pro Gly Asp Ile Leu Ile Ser Gly Phe Asn Phe Gly Thr Gly 
                565                 570                 575     


Ser Ser Arg Glu Gln Ala Ala Thr Ala Ile Leu Ala Lys Gly Ile Lys 
            580                 585                 590         


Leu Val Val Ser Gly Ser Phe Gly Asn Ile Phe Phe Arg Asn Ser Ile 
        595                 600                 605             


Asn Asn Ala Leu Leu Thr Leu Glu Ile Pro Ala Leu Ile Asn Met Leu 
    610                 615                 620                 


Arg Asp Arg Tyr Lys Asp Ala Pro Lys Glu Leu Thr Arg Arg Thr Gly 
625                 630                 635                 640 


Trp Phe Leu Lys Trp Asp Val Ser Gln Ala Lys Val Tyr Val Thr Glu 
                645                 650                 655     


Gly Ser Val Asn Gly Pro Ile Val Leu Glu Gln Lys Val Gly Glu Leu 
            660                 665                 670         


Gly Lys Asn Leu Gln Glu Ile Ile Val Lys Gly Gly Leu Glu Ser Trp 
        675                 680                 685             


Val Lys Ser Gln Leu 
    690             


<210>  57
<211>  693
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  57

Met Leu Arg Ser Thr Thr Phe Thr Arg Ser Phe His Ser Ser Arg Ala 
1               5                   10                  15      


Trp Leu Lys Gly Gln Asn Leu Thr Glu Lys Ile Val Gln Ser Tyr Ala 
            20                  25                  30          


Val Asn Leu Pro Glu Gly Lys Val Val His Ser Gly Asp Tyr Val Ser 
        35                  40                  45              


Ile Lys Pro Ala His Cys Met Ser His Asp Asn Ser Trp Pro Val Ala 
    50                  55                  60                  


Leu Lys Phe Met Gly Leu Gly Ala Thr Lys Ile Lys Asn Pro Ser Gln 
65                  70                  75                  80  


Ile Val Thr Thr Leu Asp His Asp Ile Gln Asn Lys Ser Glu Lys Asn 
                85                  90                  95      


Leu Thr Lys Tyr Lys Asn Ile Glu Asn Phe Ala Lys Lys His His Ile 
            100                 105                 110         


Asp His Tyr Pro Ala Gly Arg Gly Ile Gly His Gln Ile Met Ile Glu 
        115                 120                 125             


Glu Gly Tyr Ala Phe Pro Leu Asn Met Thr Val Ala Ser Asp Ser His 
    130                 135                 140                 


Ser Asn Thr Tyr Gly Gly Leu Gly Ser Leu Gly Thr Pro Ile Val Arg 
145                 150                 155                 160 


Thr Asp Ala Ala Ala Ile Trp Ala Thr Gly Gln Thr Trp Trp Gln Ile 
                165                 170                 175     


Pro Pro Val Ala Gln Val Glu Leu Lys Gly Gln Leu Pro Gln Gly Val 
            180                 185                 190         


Ser Gly Lys Asp Ile Ile Val Ala Leu Cys Gly Leu Phe Asn Asn Asp 
        195                 200                 205             


Gln Val Leu Asn His Ala Ile Glu Phe Thr Gly Asp Ser Leu Asn Ala 
    210                 215                 220                 


Leu Pro Ile Asp His Arg Leu Thr Ile Ala Asn Met Thr Thr Glu Trp 
225                 230                 235                 240 


Gly Ala Leu Ser Gly Leu Phe Pro Val Asp Lys Thr Leu Ile Asp Trp 
                245                 250                 255     


Tyr Lys Asn Arg Leu Gln Lys Leu Gly Thr Asn Asn His Pro Arg Ile 
            260                 265                 270         


Asn Pro Lys Thr Ile Arg Ala Leu Glu Glu Lys Ala Lys Ile Pro Lys 
        275                 280                 285             


Ala Asp Lys Asp Ala His Tyr Ala Lys Lys Leu Ile Ile Asp Leu Ala 
    290                 295                 300                 


Thr Leu Thr His Tyr Val Ser Gly Pro Asn Ser Val Lys Val Ser Asn 
305                 310                 315                 320 


Thr Val Gln Asp Leu Ser Gln Gln Asp Ile Lys Ile Asn Lys Ala Tyr 
                325                 330                 335     


Leu Val Ser Cys Thr Asn Ser Arg Leu Ser Asp Leu Gln Ser Ala Ala 
            340                 345                 350         


Asp Val Val Cys Pro Thr Gly Asp Leu Asn Lys Val Asn Lys Val Ala 
        355                 360                 365             


Pro Gly Val Glu Phe Tyr Val Ala Ala Ala Ser Ser Glu Ile Glu Ala 
    370                 375                 380                 


Asp Ala Arg Lys Ser Gly Ala Trp Glu Lys Leu Leu Lys Ala Gly Cys 
385                 390                 395                 400 


Ile Pro Leu Pro Ser Gly Cys Gly Pro Cys Ile Gly Leu Gly Ala Gly 
                405                 410                 415     


Leu Leu Glu Pro Gly Glu Val Gly Ile Ser Ala Thr Asn Arg Asn Phe 
            420                 425                 430         


Lys Gly Arg Met Gly Ser Lys Asp Ala Leu Ala Tyr Leu Ala Ser Pro 
        435                 440                 445             


Ala Val Val Ala Ala Ser Ala Val Leu Gly Lys Ile Ser Ser Pro Ala 
    450                 455                 460                 


Glu Val Leu Ser Thr Ser Glu Ile Pro Phe Ser Gly Val Lys Thr Glu 
465                 470                 475                 480 


Ile Ile Glu Asn Pro Val Val Glu Glu Glu Val Asn Ala Gln Thr Glu 
                485                 490                 495     


Ala Pro Lys Gln Ser Val Glu Ile Leu Glu Gly Phe Pro Arg Glu Phe 
            500                 505                 510         


Ser Gly Glu Leu Val Leu Cys Asp Ala Asp Asn Ile Asn Thr Asp Gly 
        515                 520                 525             


Ile Tyr Pro Gly Lys Tyr Thr Tyr Gln Asp Asp Val Pro Lys Glu Lys 
    530                 535                 540                 


Met Ala Gln Val Cys Met Glu Asn Tyr Asp Ala Glu Phe Arg Thr Lys 
545                 550                 555                 560 


Val His Pro Gly Asp Ile Val Val Ser Gly Phe Asn Phe Gly Thr Gly 
                565                 570                 575     


Ser Ser Arg Glu Gln Ala Ala Thr Ala Leu Leu Ala Lys Gly Ile Asn 
            580                 585                 590         


Leu Val Val Ser Gly Ser Phe Gly Asn Ile Phe Ser Arg Asn Ser Ile 
        595                 600                 605             


Asn Asn Ala Leu Leu Thr Leu Glu Ile Pro Ala Leu Ile Lys Lys Leu 
    610                 615                 620                 


Arg Glu Lys Tyr Gln Gly Ala Pro Lys Glu Leu Thr Arg Arg Thr Gly 
625                 630                 635                 640 


Trp Phe Leu Lys Trp Asp Val Ala Asp Ala Lys Val Val Val Thr Glu 
                645                 650                 655     


Gly Ser Leu Asp Gly Pro Val Ile Leu Glu Gln Lys Val Gly Glu Leu 
            660                 665                 670         


Gly Lys Asn Leu Gln Glu Ile Ile Val Lys Gly Gly Leu Glu Gly Trp 
        675                 680                 685             


Val Lys Ser Gln Leu 
    690             


<210>  58
<211>  769
<212>  PRT
<213>  Aspergillus niger

<400>  58

Met Gln Ser Arg Leu Leu Pro Ser Gly Pro Gly Arg Arg Trp Ile Ser 
1               5                   10                  15      


Leu Arg Val Pro Asn Thr Pro Gln Arg Arg Ala Phe Ala Ser Thr Arg 
            20                  25                  30          


Phe Leu Phe Gln Asp Val Phe Gln Ser Gln Leu Asp Asp Pro Ser Ser 
        35                  40                  45              


Ala Ala Leu Phe Ser Ser Leu Gln Ser Ser Arg Ala Val Pro Gln Thr 
    50                  55                  60                  


Leu Thr Glu Lys Ile Val Gln Lys Tyr Ala Val Gly Leu Pro Asp Gly 
65                  70                  75                  80  


Lys Phe Val Lys Ser Gly Asp Tyr Val Thr Ile Ala Pro His Arg Ile 
                85                  90                  95      


Met Thr His Asp Asn Ser Trp Pro Val Ala Leu Lys Phe Met Ser Ile 
            100                 105                 110         


Gly Ala Ser Lys Met His Asp Pro Asn Gln Val Val Met Thr Leu Asp 
        115                 120                 125             


His Asp Val Gln Asn Lys Thr Glu Lys Asn Leu Gln Lys Tyr Arg Gln 
    130                 135                 140                 


Ile Glu Glu Phe Ala Lys Gln His Gly Val Glu Phe Tyr Pro Ala Gly 
145                 150                 155                 160 


Arg Gly Ile Gly His Gln Ile Met Val Glu Glu Gly Phe Ala Trp Pro 
                165                 170                 175     


Gly Thr Leu Val Val Ala Ser Asp Ser His Ser Asn Thr Tyr Gly Ala 
            180                 185                 190         


Val Ala Ser Val Gly Thr Pro Ile Val Arg Thr Asp Ala Ala Ser Ile 
        195                 200                 205             


Trp Ala Thr Gly Lys Thr Trp Trp Gln Ile Pro Pro Val Ala Lys Val 
    210                 215                 220                 


Thr Phe Thr Gly Ile Leu Pro Pro Gly Val Thr Gly Lys Asp Val Ile 
225                 230                 235                 240 


Val Ala Leu Cys Gly Leu Phe Asp Lys Asp Asp Val Leu Asn His Ala 
                245                 250                 255     


Ile Glu Phe Thr Gly Ser Glu Glu Thr Met Arg Ser Leu Pro Met Asp 
            260                 265                 270         


Ser Arg Leu Thr Ile Ala Asn Met Thr Thr Glu Trp Gly Ala Leu Ser 
        275                 280                 285             


Gly Leu Phe Pro Met Asp Gly Val Leu Lys Gly Trp Leu Lys Gly Lys 
    290                 295                 300                 


Ala Thr Thr Ala Ala Met Gly Leu Ala Asp Gly Pro Phe Lys Thr Leu 
305                 310                 315                 320 


Ala Ala Arg Asn Phe Thr His Pro Ala Ile Glu Gln Leu Phe Val Asn 
                325                 330                 335     


Pro Leu Thr Ala Asp Lys Gly Ala Lys Tyr Ala Lys Glu Leu Phe Leu 
            340                 345                 350         


Asp Leu Ser Thr Leu Ser Pro Tyr Val Ser Gly Pro Asn Ser Val Lys 
        355                 360                 365             


Ile Ala Thr Pro Leu Lys Glu Leu Glu Ala Gln Asp Ile Lys Val Asp 
    370                 375                 380                 


Lys Ala Tyr Leu Val Ser Cys Thr Asn Ser Arg Ala Ser Asp Ile Ala 
385                 390                 395                 400 


Ala Ala Ala Lys Val Phe Lys Asp Ala Ala Glu Lys Asn Gly Gly Lys 
                405                 410                 415     


Val Pro Lys Ile Ala Asp Gly Val Lys Phe Tyr Ile Ala Ala Ala Ser 
            420                 425                 430         


Ile Pro Glu Gln Leu Ala Ala Glu Gly Ala Gly Asp Trp Gln Thr Leu 
        435                 440                 445             


Leu Glu Ala Gly Ala Thr Ala Leu Pro Ala Gly Cys Gly Pro Cys Ile 
    450                 455                 460                 


Gly Leu Gly Thr Gly Leu Leu Glu Pro Gly Glu Val Gly Ile Ser Ala 
465                 470                 475                 480 


Ser Asn Arg Asn Phe Lys Gly Arg Met Gly Ser Thr Glu Ala Lys Ala 
                485                 490                 495     


Tyr Leu Gly Ser Pro Glu Ile Val Ala Ala Ser Ala Leu Ser Gly Lys 
            500                 505                 510         


Leu Ser Gly Pro Gly Trp Tyr Gln Pro Pro Glu Gly Trp Thr Glu Val 
        515                 520                 525             


Val Arg Gly Glu Gly Asp Gly Ile Arg Glu Glu Asp Arg Met Leu Asn 
    530                 535                 540                 


Thr Glu Gln Ala Leu Glu Lys Leu Leu Gly Gln Leu Asp Asp Leu Val 
545                 550                 555                 560 


Ala Asp Gly Glu Lys Arg Phe Ala Pro Glu Glu Lys Val Glu Glu Glu 
                565                 570                 575     


Gly Gly Leu Thr Glu Val Tyr Pro Gly Phe Pro Glu Arg Val Ser Gly 
            580                 585                 590         


Glu Ile Val Phe Cys Asp Ala Asp Asn Leu Asn Thr Asp Ala Ile Tyr 
        595                 600                 605             


Pro Gly Tyr Trp Thr Tyr Gln Asp Asn Val Pro Val Glu Lys Met Ala 
    610                 615                 620                 


Glu Val Cys Met Ser Asn Tyr Asp Lys Glu Phe Ala Ser Ile Ala Lys 
625                 630                 635                 640 


Glu Gly Asp Ile Leu Val Val Gly Tyr Asn Phe Gly Cys Gly Ser Ser 
                645                 650                 655     


Arg Glu Gln Ala Ala Thr Ala Leu Leu Ala Lys Gln Ile Pro Leu Val 
            660                 665                 670         


Val Ser Gly Ser Phe Gly Asn Ile Phe Ser Arg Asn Ser Ile Asn Asn 
        675                 680                 685             


Ala Leu Met Gly Leu Glu Val Pro Arg Leu Val Ser Arg Leu Arg Glu 
    690                 695                 700                 


Glu Phe Gly Asp Lys Gln Leu Thr Arg Arg Thr Gly Trp Thr Leu Thr 
705                 710                 715                 720 


Trp Asp Val Arg Arg Ser Gln Ile Glu Ile Gln Glu Gly Gln Asn Gly 
                725                 730                 735     


Pro Lys Trp Thr His Lys Val Gly Glu Leu Pro Pro Asn Val Gln Glu 
            740                 745                 750         


Ile Ile Ala Lys Gly Gly Leu Glu Lys Trp Val Lys Asn Ala Ile Glu 
        755                 760                 765             


Ala 
    


<210>  59
<211>  776
<212>  PRT
<213>  Emericella nidulans

<400>  59

Met Gln Ser Arg Leu Val Ser Gln Ser Gly Leu Gly Arg Arg Trp Ala 
1               5                   10                  15      


Val Leu Arg Cys Ala Leu Ser Lys Thr Tyr Gln Arg Arg Thr Leu Thr 
            20                  25                  30          


Ser Thr Arg Arg Gln Phe Gln Asp Val Phe Gln Ser Gln Leu Glu Asp 
        35                  40                  45              


Pro Thr Ser Ala Ala Leu Phe Ser Ala Leu Asn Ser Ser Lys Ala Val 
    50                  55                  60                  


Pro Gln Thr Leu Thr Glu Lys Ile Val Gln Lys Tyr Ser Val Gly Leu 
65                  70                  75                  80  


Pro Gln Gly Lys Phe Val Lys Ser Gly Asp Tyr Val Thr Ile Gln Pro 
                85                  90                  95      


His Arg Cys Met Thr His Asp Asn Ser Trp Pro Cys Ala Leu Lys Phe 
            100                 105                 110         


Met Ser Ile Gly Ala Ser Arg Leu His Asn Pro Asp Gln Ile Val Met 
        115                 120                 125             


Thr Leu Asp His Asp Val Gln Asn Lys Ser Asp Lys Asn Leu Lys Lys 
    130                 135                 140                 


Tyr Arg Gln Ile Glu Glu Phe Ala Thr Gln His Gly Val Glu Phe Tyr 
145                 150                 155                 160 


Pro Ala Gly Arg Gly Ile Gly His Gln Ile Met Ile Glu Glu Gly Phe 
                165                 170                 175     


Ala Trp Pro Gly Thr Leu Ala Val Ala Ser Asp Ser His Ser Asn Met 
            180                 185                 190         


Tyr Gly Gly Val Gly Cys Leu Gly Thr Pro Ile Val Arg Thr Asp Ala 
        195                 200                 205             


Ala Ser Val Trp Ala Thr Gly Lys Thr Trp Trp Gln Ile Pro Pro Val 
    210                 215                 220                 


Ala Lys Val Thr Phe Lys Gly Val Leu Pro Pro Gly Val Thr Gly Lys 
225                 230                 235                 240 


Asp Val Ile Val Ala Leu Cys Gly Leu Phe Asn Lys Asp Asp Val Leu 
                245                 250                 255     


Asn His Ala Ile Glu Phe Thr Gly Ser Glu Glu Thr Met Arg Ser Leu 
            260                 265                 270         


Ser Val Asp Thr Arg Leu Thr Ile Ala Asn Met Thr Thr Glu Trp Gly 
        275                 280                 285             


Ala Leu Ser Gly Leu Phe Pro Ile Asp Ser Val Leu Lys Gly Trp Leu 
    290                 295                 300                 


Arg Gly Lys Ala Thr Thr Ala Ala Met Gly Leu Ala Asp Gly Pro Phe 
305                 310                 315                 320 


Lys Thr Arg Ala Ala Glu Arg Phe Thr His Pro Leu Leu Glu Gln Leu 
                325                 330                 335     


Phe Glu Asn Pro Leu Thr Ala Asp Lys Gly Ala Lys Tyr Ala Lys Glu 
            340                 345                 350         


Leu Phe Leu Asp Leu Ser Ser Leu Ser Pro Tyr Val Ser Gly Pro Asn 
        355                 360                 365             


Ser Val Lys Val Ala Thr Pro Leu Lys Glu Leu Glu Ala Gln Asn Ile 
    370                 375                 380                 


Lys Val Asp Lys Ala Tyr Leu Val Ser Cys Thr Asn Ser Arg Ala Ser 
385                 390                 395                 400 


Asp Ile Ala Ala Ala Ala Lys Val Phe Lys Glu Ala Ala Glu Lys Asn 
                405                 410                 415     


Gly Gly Lys Ile Pro Lys Ile Ala Asp Gly Val Lys Phe Tyr Ile Ala 
            420                 425                 430         


Ala Ala Ser Ile Pro Glu Gln Leu Ala Ala Glu Gly Asn Gly Asp Trp 
        435                 440                 445             


Gln Thr Leu Leu Glu Ala Gly Ala Thr Gln Leu Pro Ala Gly Cys Gly 
    450                 455                 460                 


Pro Cys Ile Gly Met Gly Gln Gly Leu Leu Glu Pro Gly Glu Val Gly 
465                 470                 475                 480 


Ile Ser Ala Ser Asn Arg Asn Phe Lys Gly Arg Met Gly Ser Thr Glu 
                485                 490                 495     


Ala Lys Ala Tyr Leu Gly Ser Pro Glu Val Val Ala Ala Ser Ala Leu 
            500                 505                 510         


Ser Gly Lys Leu Ser Gly Pro Gly Trp Tyr Gln Thr Pro Glu Gly Trp 
        515                 520                 525             


Thr Glu Val Ile Arg Gly Glu Gly Asp Gly Ile Arg Glu Glu Asp Arg 
    530                 535                 540                 


Met Leu Thr Asn Glu Glu Ala Leu Glu Lys Ile Ile Gly Gln Leu Asp 
545                 550                 555                 560 


Asp Leu Val Ala Asp Gly Glu Lys Arg Phe Ala Ser Glu Thr Pro Ala 
                565                 570                 575     


Val Glu Glu Ser Glu Gln Gly Leu Thr Glu Ile Tyr Pro Gly Phe Pro 
            580                 585                 590         


Glu Arg Val Ser Gly Glu Leu Val Phe Cys Asp Ala Asp Asn Val Asn 
        595                 600                 605             


Thr Asp Gly Ile Tyr Pro Gly Lys Tyr Thr Tyr Gln Asp Asp Val Pro 
    610                 615                 620                 


Pro Glu Thr Met Ala Arg Val Cys Met Glu Asn Tyr Asp Pro Glu Phe 
625                 630                 635                 640 


Ser Thr Thr Ala Lys Glu Gly Asp Ile Leu Val Ser Gly Phe Asn Phe 
                645                 650                 655     


Gly Cys Gly Ser Ser Arg Glu Gln Ala Ala Thr Ala Ile Leu Ala Lys 
            660                 665                 670         


Lys Ile Pro Leu Val Val Ser Gly Ser Phe Gly Asn Ile Phe Ser Arg 
        675                 680                 685             


Asn Ser Ile Asn Asn Ala Leu Met Gly Leu Glu Val Pro Arg Leu Val 
    690                 695                 700                 


Asn Arg Leu Arg Glu Thr Phe Gly Ser Gly Asp Lys Val Leu Thr Arg 
705                 710                 715                 720 


Arg Thr Gly Trp Thr Leu Thr Trp Asp Val Arg Lys Ser Gln Ile Glu 
                725                 730                 735     


Val Gln Glu Gly Pro Gly Gly Pro Lys Trp Thr His Lys Val Gly Glu 
            740                 745                 750         


Leu Pro Pro Asn Val Gln Glu Ile Ile Ala Lys Gly Gly Leu Glu Lys 
        755                 760                 765             


Trp Val Lys Asn Ala Ile Gly Ala 
    770                 775     


<210>  60
<211>  774
<212>  PRT
<213>  Penicillium chrysogenum

<400>  60

Met Pro Ser Ala Glu Ser Gly Pro Lys Thr Leu Tyr Asp Lys Val Phe 
1               5                   10                  15      


Gln Asp His Ile Val Asn Glu Gln Glu Asp Gly Thr Cys Leu Ile Tyr 
            20                  25                  30          


Ile Asp Arg His Leu Val His Glu Val Thr Ser Pro Gln Ala Phe Glu 
        35                  40                  45              


Gly Leu Lys Asn Ala Ser Arg Gln Val Arg Arg Pro Asp Cys Thr Leu 
    50                  55                  60                  


Ala Thr Val Asp His Asn Ile Pro Thr Ser Ser Arg Lys Asn Phe Lys 
65                  70                  75                  80  


Asn Ala Ala Asp Phe Ile Lys Glu Asn Asp Ser Arg Leu Gln Cys Thr 
                85                  90                  95      


Thr Leu Glu Glu Asn Val Lys Asp Phe Gly Leu Thr Tyr Phe Gly Met 
            100                 105                 110         


Gly Asp Lys Arg Gln Gly Ile Val His Ile Ile Gly Pro Glu Gln Gly 
        115                 120                 125             


Phe Thr Leu Pro Gly Thr Thr Val Val Cys Gly Asp Ser His Thr Ser 
    130                 135                 140                 


Thr His Gly Ala Phe Gly Ala Leu Ala Phe Gly Ile Gly Thr Ser Glu 
145                 150                 155                 160 


Val Glu His Val Leu Ala Thr Gln Thr Leu Ile Thr Arg Arg Ser Lys 
                165                 170                 175     


Asn Met Arg Ile Gln Val Asp Gly Glu Leu Pro Ala Gly Val Thr Ser 
            180                 185                 190         


Lys Asp Val Val Leu His Ile Ile Gly Val Ile Gly Thr Ala Gly Gly 
        195                 200                 205             


Asn Gly Ala Val Ile Glu Phe Cys Gly Ser Val Ile Arg Gly Leu Ser 
    210                 215                 220                 


Met Glu Ala Arg Met Ser Met Cys Asn Met Ser Ile Glu Gly Gly Ala 
225                 230                 235                 240 


Arg Ala Gly Met Ile Ala Pro Asp Glu Ile Thr Phe Glu Tyr Leu Lys 
                245                 250                 255     


Gly Arg Pro Leu Ala Pro Lys Tyr Gly Ser Ala Glu Trp Asn Lys Ala 
            260                 265                 270         


Thr Ser Tyr Trp Ser Ser Leu Lys Ser Asp Ala Gly Ala Lys Tyr Asp 
        275                 280                 285             


Ser Glu Val Phe Ile Asp Gly Lys Asp Ile Ile Pro Thr Ile Ser Trp 
    290                 295                 300                 


Gly Thr Ser Pro Gln Asp Val Val Pro Ile Thr Gly Val Val Pro Ser 
305                 310                 315                 320 


Pro Asp Asp Phe Glu Asp Glu Asn Arg Lys Ala Ser Cys Lys Arg Ala 
                325                 330                 335     


Leu Glu Tyr Met Gly Leu Val Ser Gly Thr Pro Met Lys Asp Val Val 
            340                 345                 350         


Val Asp Lys Val Phe Ile Gly Ser Cys Thr Asn Ala Arg Ile Glu Asp 
        355                 360                 365             


Leu Arg Ala Ala Ala Lys Val Val Asn Gly Arg Lys Val Ala Ser Asn 
    370                 375                 380                 


Ile Lys Arg Ala Met Ile Val Pro Gly Ser Gly Leu Val Lys Glu Gln 
385                 390                 395                 400 


Ala Glu Ser Glu Gly Leu Asp Lys Val Phe Thr Asp Ala Gly Phe Glu 
                405                 410                 415     


Trp Arg Glu Ala Gly Cys Ser Met Cys Leu Gly Met Asn Pro Asp Ile 
            420                 425                 430         


Leu Ser Pro Lys Glu Arg Cys Ala Ser Thr Ser Asn Arg Asn Phe Glu 
        435                 440                 445             


Gly Arg Gln Gly Ala Gln Gly Arg Thr His Leu Met Ser Pro Ala Met 
    450                 455                 460                 


Ala Ala Thr Ala Ala Ile Val Gly Lys Leu Ala Asp Val Arg Glu His 
465                 470                 475                 480 


Val Val Ala Ser Pro Val Leu Gly Lys Ala Ser Pro Lys Ile Asp Val 
                485                 490                 495     


Gln Pro Val Phe Glu Ser Pro Glu Thr Glu Asp Glu Leu Asp Arg Val 
            500                 505                 510         


Leu Asp Arg Pro Ala Asp Asn Glu Pro His Thr Asn Ser Ser Ala Pro 
        515                 520                 525             


Ala Ser Gly Gly Gly Lys Ser Thr Gly Leu Pro Thr Phe Thr Thr Leu 
    530                 535                 540                 


Lys Gly Ile Ala Ala Pro Leu Asp Arg Ala Asn Val Asp Thr Asp Ala 
545                 550                 555                 560 


Ile Ile Pro Lys Gln Phe Leu Lys Thr Ile Lys Arg Thr Gly Leu Gly 
                565                 570                 575     


Thr Ala Leu Phe Tyr Glu Leu Arg Tyr Thr Asp Asp Lys Glu Asn Pro 
            580                 585                 590         


Asp Phe Val Leu Asn Gln Gly Ile Tyr Arg Asp Ser Lys Ile Leu Val 
        595                 600                 605             


Val Thr Gly Pro Asn Phe Gly Cys Gly Ser Ser Arg Glu His Ala Pro 
    610                 615                 620                 


Trp Ala Leu Leu Asp Phe Gly Ile Lys Cys Ile Ile Ala Pro Ser Phe 
625                 630                 635                 640 


Ala Asp Ile Phe Phe Asn Asn Thr Phe Lys Asn Gly Met Leu Pro Val 
                645                 650                 655     


Val Val Ser Asp Glu Val Ala Leu Gln Lys Ile Ala Asp Glu Ala Arg 
            660                 665                 670         


Ala Gly Arg Glu Val Glu Val Asp Leu Val Asn Gln Glu Ile Lys Asp 
        675                 680                 685             


Ala Gln Gly Asn Lys Ile Thr Ser Phe Glu Val Glu Ala Phe Arg Lys 
    690                 695                 700                 


His Cys Leu Ile Asn Gly Leu Asp Asp Ile Gly Leu Thr Leu Gln Met 
705                 710                 715                 720 


Glu Ser Lys Ile Arg Ser Phe Glu Ser Lys Arg Thr Leu Asp Thr Pro 
                725                 730                 735     


Trp Leu Asp Gly Ser Ala Tyr Leu Arg Arg Asp Arg Arg Gly Ala Thr 
            740                 745                 750         


Met Val Glu Ala Ala Pro Val Pro Lys Thr Asn Arg Gly Asp Val Lys 
        755                 760                 765             


Asn Glu Pro Leu Glu Trp 
    770                 


<210>  61
<211>  785
<212>  PRT
<213>  Penicillium chrysogenum

<400>  61

Met Ser Pro Cys Ser Met Leu Leu Lys Arg Val Ala Arg Pro Pro Val 
1               5                   10                  15      


Ser Thr Thr Cys Arg Leu Val Arg Pro Arg Trp Ala Pro Ser Phe Gly 
            20                  25                  30          


Val Pro Ser Arg Thr Ile His His Pro Leu Arg Ser Val Ser Lys Ser 
        35                  40                  45              


Leu Ser Thr Arg Ala Leu Ser Thr Thr Ala Pro Ala Arg Val Glu Gly 
    50                  55                  60                  


Phe His Ser Gln His Glu Asn Ala Ser Ile Pro Phe Ser Glu Thr Pro 
65                  70                  75                  80  


Ser Glu Lys Arg Thr Pro Gln Thr Leu Thr Glu Lys Ile Val Gln Arg 
                85                  90                  95      


Tyr Ala Val Gly Leu Pro Glu Gly Lys Leu Val Arg Ser Gly Asp Tyr 
            100                 105                 110         


Ile Ser Leu Ala Pro Gly Tyr Cys Met Thr His Asp Asn Ser Trp Pro 
        115                 120                 125             


Val Ala Leu Lys Phe Met Ser Met Gly Ala Thr Lys Ile His Arg Pro 
    130                 135                 140                 


Glu Gln Ile Val Met Thr Leu Asp His Asp Val Gln Asn Thr Ser Ala 
145                 150                 155                 160 


Ala Asn Leu Lys Lys Tyr Glu Gln Ile Glu Thr Phe Ala Gly Gln His 
                165                 170                 175     


Gly Ile Asp Phe Tyr Pro Ala Gly Arg Gly Ile Gly His Gln Val Met 
            180                 185                 190         


Val Glu Glu Gly Tyr Ala Trp Pro Gly Thr Met Ala Val Ala Ser Asp 
        195                 200                 205             


Ser His Ser Asn His Tyr Gly Gly Val Gly Cys Leu Gly Thr Ala Val 
    210                 215                 220                 


Val Arg Thr Asp Ala Ala Ser Ile Trp Ala Thr Ser Arg Thr Trp Trp 
225                 230                 235                 240 


Gln Ile Pro Pro Val Ala Arg Val Thr Phe Thr Gly Thr Leu Pro Ala 
                245                 250                 255     


Gly Val Thr Gly Lys Asp Val Ile Val Ala Leu Cys Gly Leu Phe Asn 
            260                 265                 270         


Ser Asp Val Leu Asn His Ala Ile Glu Phe Thr Gly Ser Glu Glu Thr 
        275                 280                 285             


Met Glu Ser Leu Leu Val Asp Ser Arg Leu Thr Ile Ala Asn Met Thr 
    290                 295                 300                 


Thr Glu Trp Gly Ala Leu Thr Gly Leu Phe Pro Ile Asp Arg Thr Leu 
305                 310                 315                 320 


Lys Arg Trp Leu Arg Tyr Lys Ala Thr Glu Ala Ala Met Ser Glu Asp 
                325                 330                 335     


Arg Thr Thr Arg Gln Arg Ile Thr His Glu Arg Ile Asp Glu Leu Phe 
            340                 345                 350         


Ala Asn Pro Leu Thr Ala Asp Pro Asp Ala Gln Tyr Ala Lys Gln Leu 
        355                 360                 365             


Tyr Leu Asn Leu Ser Thr Leu Ser Pro Tyr Val Ser Gly Pro Asn Ser 
    370                 375                 380                 


Val Lys Val Ala Thr Pro Leu Asn Glu Leu Ala Gln Gln Asn Ile Lys 
385                 390                 395                 400 


Val Asn Arg Ala Tyr Ile Val Ser Cys Thr Asn Ser Arg Ala Ser Asp 
                405                 410                 415     


Leu Ala Ala Ala Ala Lys Val Phe Lys Asp Ala Ala Lys Ala Asn Pro 
            420                 425                 430         


Gly Thr Thr Pro Lys Ile Ala Asp Gly Val Lys Leu Tyr Ile Ala Ala 
        435                 440                 445             


Ala Ser Ala Pro Glu Gln Glu Ala Ala Glu Ser Thr Gly Asp Trp Gln 
    450                 455                 460                 


Ala Leu Leu Asp Ala Gly Ala Gln Pro Leu Pro Ala Gly Cys Gly Pro 
465                 470                 475                 480 


Cys Ile Gly Leu Gly Thr Gly Leu Leu Glu Pro Gly Glu Val Gly Ile 
                485                 490                 495     


Ser Ala Ser Asn Arg Asn Phe Lys Gly Arg Met Gly Ser Arg Asp Ala 
            500                 505                 510         


Leu Ala Tyr Leu Ala Ser Pro Glu Val Val Ala Ala Ser Ala Leu Ser 
        515                 520                 525             


Gly Val Ile Ser Gly Pro Gly Ala Tyr Gln Val Pro Glu Asn Trp Ser 
    530                 535                 540                 


Gly Val Glu His Gly Phe Gly Thr Gly Leu Pro Pro Thr Thr Glu Asn 
545                 550                 555                 560 


Glu Leu Thr Asn Leu Leu Gln Gln Met Glu Ser Leu Ile Asp Arg Val 
                565                 570                 575     


Glu Ser Ala Gly Glu Asp Ser Lys Pro Ala Thr Glu Ile Leu Pro Gly 
            580                 585                 590         


Phe Pro Glu Arg Ile Ser Gly Glu Ile Val Phe Leu Asp Ala Asp Asn 
        595                 600                 605             


Leu Asp Thr Asp Asn Ile Tyr Pro Gly Lys Leu Thr Tyr Gln Asp Asn 
    610                 615                 620                 


Val Ser Lys Asp Asp Met Ala Ala Ala Cys Met Gln Asn Tyr Asp Pro 
625                 630                 635                 640 


Glu Phe Lys Gly Ile Ala Lys Pro Ser Asp Ile Leu Val Ala Gly Phe 
                645                 650                 655     


Asn Phe Gly Cys Gly Ser Ser Arg Glu Gln Ala Ala Thr Ala Ile Leu 
            660                 665                 670         


Ala Lys Gln Ile Pro Leu Val Val Ala Gly Ser Phe Gly Asn Ile Phe 
        675                 680                 685             


Ser Arg Asn Ser Ile Asn Asn Ala Leu Met Gly Leu Glu Val Pro Arg 
    690                 695                 700                 


Leu Ile Glu Arg Leu Arg Ala Ser Phe Ala Gln Pro Pro Pro Gly Asp 
705                 710                 715                 720 


Ala Gly Arg Gln Leu Thr Arg Arg Thr Gly Trp Thr Leu Thr Trp Asp 
                725                 730                 735     


Val Lys Arg Ser Val Val Glu Val Lys Glu Gly Glu Ser Gly Glu Ser 
            740                 745                 750         


Trp Thr Glu Gln Val Gly Glu Leu Pro Ala Asn Val Gln Glu Ile Ile 
        755                 760                 765             


Ala Glu Gly Gly Leu Glu Ala Trp Val Lys Gly Lys Val Ala Lys Ser 
    770                 775                 780                 


Glu 
785 


<210>  62
<211>  360
<212>  PRT
<213>  Phanerochaete chrysosporium

<400>  62

Met Ala Phe Arg Leu Pro Leu Arg Arg Ala Leu Ser Thr Ala Ala Ala 
1               5                   10                  15      


Ser Arg Ser Ser Leu Lys Ile Gly Leu Val Pro Ala Asp Gly Ile Gly 
            20                  25                  30          


Arg Glu Val Ile Pro Ala Ala Arg Gln Ala Ile Glu Ala Leu Gly Ser 
        35                  40                  45              


Asp Ile Pro Lys Pro Glu Phe Val Asp Leu Leu Ala Gly Phe Glu Leu 
    50                  55                  60                  


Phe Thr Arg Thr Gly Thr Ala Leu Pro Glu Glu Thr Val Gln Ala Leu 
65                  70                  75                  80  


Lys Glu Cys Asp Cys Ala Leu Phe Gly Ala Val Ser Ser Pro Ser Arg 
                85                  90                  95      


Arg Val Thr Gly Tyr Ser Ser Pro Ile Val Ala Leu Arg Lys Ile Leu 
            100                 105                 110         


Asp Leu Tyr Ala Asn Val Arg Pro Val Val Ala Pro Thr Pro Glu Glu 
        115                 120                 125             


Lys Pro Asn Val Asp Leu Ile Val Val Arg Glu Asn Thr Glu Cys Leu 
    130                 135                 140                 


Tyr Val Lys Gln Glu Gln Met Thr Pro Thr Glu Asn Gly Arg Glu Ala 
145                 150                 155                 160 


Arg Ala Thr Arg Val Ile Thr Glu Arg Ala Ser Arg Arg Ile Gly Gln 
                165                 170                 175     


Met Ala Phe Glu Leu Ala Lys Ala Arg Pro Arg Lys His Val Thr Ile 
            180                 185                 190         


Ile His Lys Ser Asn Val Leu Ser Ile Thr Asp Gly Leu Phe Arg Glu 
        195                 200                 205             


Thr Val Arg Ser Val Pro Arg Leu Asn Glu Gly Lys Tyr Asp Asp Val 
    210                 215                 220                 


Glu Ile Ala Glu Gln Leu Val Asp Ser Ala Val Tyr Arg Leu Phe Arg 
225                 230                 235                 240 


Glu Pro His Ile Tyr Asp Val Met Val Ala Pro Asn Leu Tyr Gly Asp 
                245                 250                 255     


Ile Ile Ser Asp Ala Ala Ala Ala Leu Val Gly Ser Leu Gly Leu Val 
            260                 265                 270         


Pro Ser Val Asn Ala Gly Asp Asn Phe Val Met Gly Glu Pro Val His 
        275                 280                 285             


Gly Ser Ala Pro Asp Ile Ala Gly Gln Gly Ile Ala Asn Pro Ile Ala 
    290                 295                 300                 


Ser Ile Arg Ser Ala Ala Leu Met Leu Arg His Leu Gly Tyr Gly Ala 
305                 310                 315                 320 


Pro Ala Asp Arg Leu Asp Lys Ala Val Asp Glu Val Ile Arg Glu Gly 
                325                 330                 335     


Gln Ile Leu Thr Pro Asp Leu Gly Gly Lys Ser Lys Thr Gln Asp Val 
            340                 345                 350         


Val Asp Ala Val Leu Lys Arg Ile 
        355                 360 


<210>  63
<211>  362
<212>  PRT
<213>  Schizosaccharomyces pombe

<400>  63

Met Ser Ala Thr Arg Arg Ile Val Leu Gly Leu Ile Pro Ala Asp Gly 
1               5                   10                  15      


Ile Gly Lys Glu Val Val Pro Ala Ala Arg Arg Leu Met Glu Asn Leu 
            20                  25                  30          


Pro Ala Lys His Lys Leu Lys Phe Asp Phe Ile Asp Leu Asp Ala Gly 
        35                  40                  45              


Trp Gly Thr Phe Glu Arg Thr Gly Lys Ala Leu Pro Glu Arg Thr Val 
    50                  55                  60                  


Glu Arg Leu Lys Thr Glu Cys Asn Ala Ala Leu Phe Gly Ala Val Gln 
65                  70                  75                  80  


Ser Pro Thr His Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu 
                85                  90                  95      


Arg Lys Lys Met Gly Leu Tyr Ala Asn Val Arg Pro Val Lys Ser Leu 
            100                 105                 110         


Asp Gly Ala Lys Gly Lys Pro Val Asp Leu Val Ile Val Arg Glu Asn 
        115                 120                 125             


Thr Glu Cys Leu Tyr Val Lys Glu Glu Arg Met Val Gln Asn Thr Pro 
    130                 135                 140                 


Gly Lys Arg Val Ala Glu Ala Ile Arg Arg Ile Ser Glu Glu Ala Ser 
145                 150                 155                 160 


Thr Lys Ile Gly Lys Met Ala Phe Glu Ile Ala Lys Ser Arg Gln Lys 
                165                 170                 175     


Ile Arg Glu Ser Gly Thr Tyr Ser Ile His Lys Lys Pro Leu Val Thr 
            180                 185                 190         


Ile Ile His Lys Ser Asn Val Met Ser Val Thr Asp Gly Leu Phe Arg 
        195                 200                 205             


Glu Ser Cys Arg His Ala Gln Ser Leu Asp Pro Ser Tyr Ala Ser Ile 
    210                 215                 220                 


Asn Val Asp Glu Gln Ile Val Asp Ser Met Val Tyr Arg Leu Phe Arg 
225                 230                 235                 240 


Glu Pro Glu Cys Phe Asp Val Val Val Ala Pro Asn Leu Tyr Gly Asp 
                245                 250                 255     


Ile Leu Ser Asp Gly Ala Ala Ser Leu Ile Gly Ser Leu Gly Leu Val 
            260                 265                 270         


Pro Ser Ala Asn Val Gly Asp Asn Phe Val Met Ser Glu Pro Val His 
        275                 280                 285             


Gly Ser Ala Pro Asp Ile Ala Gly Arg Gly Ile Ala Asn Pro Val Ala 
    290                 295                 300                 


Thr Phe Arg Ser Val Ala Leu Met Leu Glu Phe Met Gly His Gln Asp 
305                 310                 315                 320 


Ala Ala Ala Asp Ile Tyr Thr Ala Val Asp Lys Val Leu Thr Glu Gly 
                325                 330                 335     


Lys Val Leu Thr Pro Asp Leu Gly Gly Lys Ser Gly Thr Asn Glu Ile 
            340                 345                 350         


Thr Asp Ala Val Leu Ala Asn Ile His Asn 
        355                 360         


<210>  64
<211>  360
<212>  PRT
<213>  Emericella nidulans

<400>  64

Met Ala Ala Ala Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly 
1               5                   10                  15      


Ile Gly Arg Glu Val Ile Pro Ala Gly Arg Arg Ile Leu Glu Ala Leu 
            20                  25                  30          


Pro Ala Ser Leu Asn Leu Lys Phe Asn Phe Val Asp Leu Asp Ala Gly 
        35                  40                  45              


Tyr Asp Cys Phe Lys Arg Thr Gly Thr Ala Leu Pro Asp Lys Thr Val 
    50                  55                  60                  


Glu Val Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser 
65                  70                  75                  80  


Ser Pro Ser Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu 
                85                  90                  95      


Arg Lys Lys Leu Asp Leu Phe Ala Asn Val Arg Pro Val Lys Thr Thr 
            100                 105                 110         


Ala Gly Thr Ser Ala Gly Lys Pro Ile Asp Leu Val Ile Val Arg Glu 
        115                 120                 125             


Asn Thr Glu Asp Leu Tyr Val Lys Glu Glu Ser Thr Glu Glu Thr Pro 
    130                 135                 140                 


Asn Gly Lys Val Ala Arg Ala Ile Lys Gln Ile Ser Glu Arg Ala Ser 
145                 150                 155                 160 


Ser Arg Ile Ala Thr Ile Ala Gly Glu Ile Ala Leu Arg Arg Gln Asn 
                165                 170                 175     


Ile Arg Asp Gly Ala Ala Ala Ser Gly Leu Arg Thr Lys Pro Met Val 
            180                 185                 190         


Thr Ile Thr His Lys Ser Asn Val Leu Ser Gln Thr Asp Gly Leu Phe 
        195                 200                 205             


Arg Glu Thr Ala Arg Ala Ala Leu Ala Ala Gln Lys Phe Ser Ser Val 
    210                 215                 220                 


Glu Val Glu Glu Gln Ile Val Asp Ser Met Val Tyr Lys Leu Phe Arg 
225                 230                 235                 240 


Gln Pro Glu Tyr Tyr Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp 
                245                 250                 255     


Ile Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Leu Val 
            260                 265                 270         


Pro Ser Ala Asn Val Gly Asp Asn Phe Ala Ile Gly Glu Pro Cys His 
        275                 280                 285             


Gly Ser Ala Pro Asp Ile Glu Gly Lys Asn Ile Ala Asn Pro Ile Ala 
    290                 295                 300                 


Thr Leu Arg Ser Val Ala Leu Met Leu Glu Phe Leu Gly Glu Glu Gln 
305                 310                 315                 320 


Ala Ala Ala Lys Ile Tyr Ala Ala Val Asp Gly Asn Leu Asp Glu Gly 
                325                 330                 335     


Lys Tyr Leu Ser Pro Asp Met Gly Gly Lys Ala Thr Thr Thr Glu Val 
            340                 345                 350         


Leu Glu Asp Val Leu Lys Arg Leu 
        355                 360 


<210>  65
<211>  359
<212>  PRT
<213>  Penicillium chrysogenum

<400>  65

Met Ala Ala Ala Arg Thr Leu Arg Ile Gly Leu Ile Pro Gly Asp Gly 
1               5                   10                  15      


Ile Gly Arg Glu Val Ile Pro Ala Gly Arg Arg Ile Leu Glu Ser Leu 
            20                  25                  30          


Pro Ser Ser Leu Asn Leu Lys Phe Ser Phe Val Asp Leu Asp Ala Gly 
        35                  40                  45              


Tyr Glu Thr Phe Gln Lys Thr Gly Thr Ala Leu Pro Asp Lys Thr Val 
    50                  55                  60                  


Asp Thr Leu Lys Lys Glu Cys Asp Gly Ala Leu Phe Gly Ala Val Ser 
65                  70                  75                  80  


Ser Pro Ser Thr Lys Val Ala Gly Tyr Ser Ser Pro Ile Val Ala Leu 
                85                  90                  95      


Arg Lys Lys Leu Asp Leu Tyr Ala Asn Val Arg Pro Val Lys Thr Thr 
            100                 105                 110         


Ala Gly Asn Ser Asn Gly Lys Pro Ile Asp Leu Val Ile Val Arg Glu 
        115                 120                 125             


Asn Thr Glu Asp Leu Tyr Val Lys Glu Glu Arg Thr Ile Glu Gly Pro 
    130                 135                 140                 


Asn Gly Lys Val Ala Glu Ala Ile Lys Arg Ile Ser Glu Lys Ala Ser 
145                 150                 155                 160 


Phe Arg Ile Ser Asn Ile Ala Gly Glu Ile Ala Leu Arg Arg Gln Asn 
                165                 170                 175     


Ile Arg Ala Ala Ser Pro Thr Ser Thr Arg Asp Gln Pro Met Val Thr 
            180                 185                 190         


Ile Thr His Lys Ser Asn Val Leu Ser Gln Thr Asp Gly Leu Phe Arg 
        195                 200                 205             


Glu Thr Ala Arg Arg Ala Leu Ser Ala Glu Lys Phe Ser Ser Val Phe 
    210                 215                 220                 


Val Glu Glu Gln Ile Val Asp Ser Met Val Tyr Lys Leu Phe Arg Gln 
225                 230                 235                 240 


Pro Glu Phe Tyr Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile 
                245                 250                 255     


Leu Ser Asp Gly Ala Ala Ala Leu Val Gly Ser Leu Gly Leu Val Pro 
            260                 265                 270         


Ser Ala Asn Val Gly Asp Gly Phe Ala Ile Gly Glu Pro Cys His Gly 
        275                 280                 285             


Ser Ala Pro Asp Ile Glu Gly Lys Gly Ile Ser Asn Pro Ile Ala Thr 
    290                 295                 300                 


Ile Arg Ser Val Ala Leu Met Leu Glu Phe Leu Gly Glu Glu Lys Ala 
305                 310                 315                 320 


Ala Ala Gln Ile Tyr Ala Ala Val Asp Gly Asn Leu Asp Ala Ala Gln 
                325                 330                 335     


Phe Leu Thr Pro Asp Met Gly Gly Lys Ala Thr Thr Gln Gln Val Leu 
            340                 345                 350         


Asp Asp Val Leu Lys Arg Leu 
        355                 


<210>  66
<211>  371
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  66

Met Phe Arg Ser Val Ala Thr Arg Leu Ser Ala Cys Arg Gly Leu Ala 
1               5                   10                  15      


Ser Asn Ala Ala Arg Lys Ser Leu Thr Ile Gly Leu Ile Pro Gly Asp 
            20                  25                  30          


Gly Ile Gly Lys Glu Val Ile Pro Ala Gly Lys Gln Val Leu Glu Asn 
        35                  40                  45              


Leu Asn Ser Lys His Gly Leu Ser Phe Asn Phe Ile Asp Leu Tyr Ala 
    50                  55                  60                  


Gly Phe Gln Thr Phe Gln Glu Thr Gly Lys Ala Leu Pro Asp Glu Thr 
65                  70                  75                  80  


Val Lys Val Leu Lys Glu Gln Cys Gln Gly Ala Leu Phe Gly Ala Val 
                85                  90                  95      


Gln Ser Pro Thr Thr Lys Val Glu Gly Tyr Ser Ser Pro Ile Val Ala 
            100                 105                 110         


Leu Arg Arg Glu Met Gly Leu Phe Ala Asn Val Arg Pro Val Lys Ser 
        115                 120                 125             


Val Glu Gly Glu Lys Gly Lys Pro Ile Asp Met Val Ile Val Arg Glu 
    130                 135                 140                 


Asn Thr Glu Asp Leu Tyr Ile Lys Ile Glu Lys Thr Tyr Ile Asp Lys 
145                 150                 155                 160 


Ala Thr Gly Thr Arg Val Ala Asp Ala Thr Lys Arg Ile Ser Glu Ile 
                165                 170                 175     


Ala Thr Arg Arg Ile Ala Thr Ile Ala Leu Asp Ile Ala Leu Lys Arg 
            180                 185                 190         


Leu Gln Thr Arg Gly Gln Ala Thr Leu Thr Val Thr His Lys Ser Asn 
        195                 200                 205             


Val Leu Ser Gln Ser Asp Gly Leu Phe Arg Glu Ile Cys Lys Glu Val 
    210                 215                 220                 


Tyr Glu Ser Asn Lys Asp Lys Tyr Gly Gln Ile Lys Tyr Asn Glu Gln 
225                 230                 235                 240 


Ile Val Asp Ser Met Val Tyr Arg Leu Phe Arg Glu Pro Gln Cys Phe 
                245                 250                 255     


Asp Val Ile Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser Asp Gly 
            260                 265                 270         


Ala Ala Ala Leu Val Gly Ser Leu Gly Val Val Pro Ser Ala Asn Val 
        275                 280                 285             


Gly Pro Glu Ile Val Ile Gly Glu Pro Cys His Gly Ser Ala Pro Asp 
    290                 295                 300                 


Ile Ala Gly Lys Gly Ile Ala Asn Pro Ile Ala Thr Ile Arg Ser Thr 
305                 310                 315                 320 


Ala Leu Met Leu Glu Phe Leu Gly His Asn Glu Ala Ala Gln Asp Ile 
                325                 330                 335     


Tyr Lys Ala Val Asp Ala Asn Leu Arg Glu Gly Ser Ile Lys Thr Pro 
            340                 345                 350         


Asp Leu Gly Gly Lys Ala Ser Thr Gln Gln Val Val Asp Asp Val Leu 
        355                 360                 365             


Ser Arg Leu 
    370     


<210>  67
<211>  369
<212>  PRT
<213>  Kluyveromyces lactis

<400>  67

Met Met Arg Thr Arg Phe Ile Gln Leu Ser Arg Arg Ala Tyr Ala Ser 
1               5                   10                  15      


Asn Ala Lys Asn Leu Thr Ile Gly Leu Ile Pro Gly Asp Gly Ile Gly 
            20                  25                  30          


Lys Glu Val Ile Pro Ala Gly Lys Lys Ile Leu Glu Ser Leu Asn Pro 
        35                  40                  45              


Lys Tyr Gly Leu Ser Phe Lys Phe Ile Asp Leu Gln Ala Gly Trp Glu 
    50                  55                  60                  


Thr Phe Gln Asn Thr Gly Lys Ala Leu Pro Asp Glu Thr Ile Asp Ile 
65                  70                  75                  80  


Leu Lys Asn Gln Cys Glu Gly Ala Leu Phe Gly Ala Val Gln Ser Pro 
                85                  90                  95      


Thr Thr Lys Val Glu Gly Tyr Ser Ser Pro Ile Val Ala Leu Arg Lys 
            100                 105                 110         


Asn Leu Gly Leu Phe Ala Asn Val Arg Pro Val Lys Ser Val Asp Gly 
        115                 120                 125             


Thr Lys Asp Arg Lys Val Asp Leu Val Ile Val Arg Glu Asn Thr Glu 
    130                 135                 140                 


Asp Leu Tyr Ile Lys Leu Glu Lys Ser Tyr Ile Asp Glu Ala Thr Gly 
145                 150                 155                 160 


Thr Arg Val Ala Asp Ala Thr Lys Arg Ile Thr Glu Ile Ala Thr Lys 
                165                 170                 175     


Asn Ile Ala Thr Ile Ala Leu Gln Ile Ala Gln Gln Arg Leu Glu Gln 
            180                 185                 190         


Asn Gly His Ala Thr Leu Thr Val Thr His Lys Ser Asn Val Leu Ser 
        195                 200                 205             


Gln Ser Asp Gly Leu Phe Arg Glu Val Cys Arg Glu Thr Tyr Glu Ala 
    210                 215                 220                 


Asn Lys Asp Lys Tyr Gly Gly Val Gln Tyr Asn Glu Gln Ile Val Asp 
225                 230                 235                 240 


Ser Met Val Tyr Arg Met Phe Arg Glu Pro Glu Cys Phe Asp Val Val 
                245                 250                 255     


Val Ala Pro Asn Leu Tyr Gly Asp Ile Leu Ser Asp Gly Ala Ala Ala 
            260                 265                 270         


Leu Val Gly Ser Leu Gly Val Val Pro Ser Ala Asn Val Gly Pro Asn 
        275                 280                 285             


Ile Val Ile Gly Glu Pro Cys His Gly Ser Ala Pro Asp Ile Ala Gly 
    290                 295                 300                 


Lys Gly Ile Ser Asn Pro Ile Ala Thr Ile Arg Ser Thr Ala Leu Met 
305                 310                 315                 320 


Leu Glu Phe Leu Gly Tyr Pro Glu Pro Ala Lys Asp Ile His Lys Ala 
                325                 330                 335     


Val Asp Ala Asn Ile Arg Glu Gly Lys Tyr Leu Thr Pro Asp Leu Gly 
            340                 345                 350         


Gly Asn Ser Thr Thr Gln Gln Val Leu Glu Asp Val Leu Ser Lys Leu 
        355                 360                 365             


Asp 
    


<210>  68
<211>  536
<212>  PRT
<213>  Penicillium chrysogenum

<400>  68

Met Ser Pro Pro Thr Ala Leu Asp Val Asn Leu Val Gly Val Thr Asp 
1               5                   10                  15      


Thr Ser Thr Val Pro Val Pro Glu Pro Leu Thr Val Asn Gly Val Ser 
            20                  25                  30          


Ala Trp Arg Glu Lys Thr Ala Lys Val Pro Thr Gly Val Ala Ala Ala 
        35                  40                  45              


Cys Asn Ser Asp Met Phe Lys Ser Pro Ile Cys Tyr Thr Lys Pro Lys 
    50                  55                  60                  


Ala Lys Gln Phe Glu His Arg Phe Ser Leu Glu Ala Lys Ser Arg Lys 
65                  70                  75                  80  


Ala Ser Thr Leu Lys Thr Ala Ala Arg Tyr Leu Lys Thr Pro Gly Leu 
                85                  90                  95      


Ile Ser Leu Gly Gly Gly Leu Pro Ser Pro Glu Tyr Phe Pro Phe Glu 
            100                 105                 110         


His Leu Asp Ile Lys Val Pro Thr Ala Pro Gly Phe Ser Pro Glu Ala 
        115                 120                 125             


Thr Arg Glu Ser Gly Thr Val Leu Arg Ala Gly Lys His Asp Ile Gln 
    130                 135                 140                 


Glu Gly Thr Ser Thr Tyr Asp Leu Glu Ile Ala Leu Asn Tyr Gly Gln 
145                 150                 155                 160 


Ala Thr Gly Ala Ala Pro Leu Leu Arg Phe Val Thr Glu His Thr Glu 
                165                 170                 175     


Ile Ile His Ser Pro Pro Tyr Ser Asp Trp Gln Cys Thr Leu Thr Ala 
            180                 185                 190         


Gly Ser Thr Tyr Ala Trp Asp Thr Ala Leu Arg Val Phe Cys Glu Arg 
        195                 200                 205             


Gly Asp Tyr Ile Leu Met Glu Glu Tyr Thr Phe Ala Ser Ala Ala Glu 
    210                 215                 220                 


Thr Ala Phe Pro Leu Gly Ile Lys Val Ala Gly Ile Pro Met Asp Glu 
225                 230                 235                 240 


Gln Gly Leu Ile Pro Glu Ala Met Asp Lys Ile Leu Gly Asp Trp Asp 
                245                 250                 255     


Val Ala Ala Arg Gly Ala Arg Lys Pro His Val Leu Tyr Thr Ile Pro 
            260                 265                 270         


Thr Gly Gln Asn Pro Thr Gly Ala Thr Gln Ser Ala Glu Arg Arg His 
        275                 280                 285             


Ala Val Tyr Lys Val Ala Gln Lys His Asp Leu Ile Ile Val Glu Asp 
    290                 295                 300                 


Glu Pro Tyr Tyr Phe Leu Gln Met Gln Pro Tyr Thr Ser Gly Asp Ala 
305                 310                 315                 320 


Ser Pro Val Pro Pro Pro Ser Ser His Glu Glu Phe Ile Asn Ser Leu 
                325                 330                 335     


Val Pro Ser Phe Leu Ser Met Asp Thr Asp Gly Arg Val Val Arg Leu 
            340                 345                 350         


Glu Ser Phe Ser Lys Val Ile Ser Pro Gly Ser Arg Val Gly Trp Ile 
        355                 360                 365             


Val Ala Ser Glu Gln Ile Ile Glu Arg Phe Ile Arg Asn Phe Glu Val 
    370                 375                 380                 


Ser Ser Gln Asn Pro Ser Gly Ile Ala Gln Ile Ala Leu Phe Lys Leu 
385                 390                 395                 400 


Leu Asp Glu His Trp Gly His Ser Gly Tyr Leu Asp Trp Leu Ile Asn 
                405                 410                 415     


Leu Arg Met Ser Tyr Thr Ala Arg Arg Asp Ser Leu Val His Ala Cys 
            420                 425                 430         


Glu Lys His Leu Pro Arg Glu Ile Val His Trp Glu Ala Pro Ala Ala 
        435                 440                 445             


Gly Met Phe Gln Trp Met Ser Ile Asp Trp Arg Lys His Pro Gly Ile 
    450                 455                 460                 


Ala Ala Gly Lys Thr His Ala Asp Ile Glu Glu Glu Ile Phe Leu Ser 
465                 470                 475                 480 


Ala Val Asn Gly Gly Val Leu Leu Ser Arg Gly Ser Trp Phe Lys Pro 
                485                 490                 495     


Asp His Asp Thr Val Glu Glu Lys Met Phe Phe Arg Ala Thr Phe Ala 
            500                 505                 510         


Ala Ala Ser Ser Glu Lys Ile Asp Glu Ala Ile Ser Arg Phe Ala Gln 
        515                 520                 525             


Ser Leu Arg Ala Gln Phe Gly Leu 
    530                 535     


<210>  69
<211>  376
<212>  PRT
<213>  Thermus thermophilus

<400>  69

Met Arg Glu Trp Lys Ile Ile Asp Ser Thr Leu Arg Glu Gly Glu Gln 
1               5                   10                  15      


Phe Glu Lys Ala Asn Phe Ser Thr Gln Asp Lys Val Glu Ile Ala Lys 
            20                  25                  30          


Ala Leu Asp Glu Phe Gly Ile Glu Tyr Ile Glu Val Thr Thr Pro Val 
        35                  40                  45              


Ala Ser Pro Gln Ser Arg Lys Asp Ala Glu Val Leu Ala Ser Leu Gly 
    50                  55                  60                  


Leu Lys Ala Lys Val Val Thr His Ile Gln Cys Arg Leu Asp Ala Ala 
65                  70                  75                  80  


Lys Val Ala Val Glu Thr Gly Val Gln Gly Ile Asp Leu Leu Phe Gly 
                85                  90                  95      


Thr Ser Lys Tyr Leu Arg Ala Ala His Gly Arg Asp Ile Pro Arg Ile 
            100                 105                 110         


Ile Glu Glu Ala Lys Glu Val Ile Ala Tyr Ile Arg Glu Ala Ala Pro 
        115                 120                 125             


His Val Glu Val Arg Phe Ser Ala Glu Asp Thr Phe Arg Ser Glu Glu 
    130                 135                 140                 


Gln Asp Leu Leu Ala Val Tyr Glu Ala Val Ala Pro Tyr Val Asp Arg 
145                 150                 155                 160 


Val Gly Leu Ala Asp Thr Val Gly Val Ala Thr Pro Arg Gln Val Tyr 
                165                 170                 175     


Ala Leu Val Arg Glu Val Arg Arg Val Val Gly Pro Arg Val Asp Ile 
            180                 185                 190         


Glu Phe His Gly His Asn Asp Thr Gly Cys Ala Ile Ala Asn Ala Tyr 
        195                 200                 205             


Glu Ala Ile Glu Ala Gly Ala Thr His Val Asp Thr Thr Ile Leu Gly 
    210                 215                 220                 


Ile Gly Glu Arg Asn Gly Ile Thr Pro Leu Gly Gly Phe Leu Ala Arg 
225                 230                 235                 240 


Met Tyr Thr Leu Gln Pro Glu Tyr Val Arg Arg Lys Tyr Lys Leu Glu 
                245                 250                 255     


Met Leu Pro Glu Leu Asp Arg Met Val Ala Arg Met Val Gly Val Glu 
            260                 265                 270         


Ile Pro Phe Asn Asn Tyr Ile Thr Gly Glu Thr Ala Phe Ser His Lys 
        275                 280                 285             


Ala Gly Met His Leu Lys Ala Ile Tyr Ile Asn Pro Glu Ala Tyr Glu 
    290                 295                 300                 


Pro Tyr Pro Pro Glu Val Phe Gly Val Lys Arg Lys Leu Ile Ile Ala 
305                 310                 315                 320 


Ser Arg Leu Thr Gly Arg His Ala Ile Lys Ala Arg Ala Glu Glu Leu 
                325                 330                 335     


Gly Leu His Tyr Gly Glu Glu Glu Leu His Arg Val Thr Gln His Ile 
            340                 345                 350         


Lys Ala Leu Ala Asp Arg Gly Gln Leu Thr Leu Glu Glu Leu Asp Arg 
        355                 360                 365             


Ile Leu Arg Glu Trp Ile Thr Ala 
    370                 375     


<210>  70
<211>  393
<212>  PRT
<213>  Deinococcus radiodurans

<400>  70

Met Ala Gly Ile Phe Met Thr Asp Ala Pro Pro Pro Leu Ile Pro Ala 
1               5                   10                  15      


Arg Ser Trp Ala Ile Ile Asp Ser Thr Leu Arg Glu Gly Glu Gln Phe 
            20                  25                  30          


Ala Arg Gly Asn Phe Gly Thr Asp Asp Lys Val Glu Ile Ala Arg Ala 
        35                  40                  45              


Leu Asp Ala Phe Gly Ala Glu Tyr Ile Glu Val Thr Thr Pro Met Val 
    50                  55                  60                  


Ser Glu Gln Thr Arg Gln Asp Ile Arg Lys Leu Thr Gly Leu Gly Leu 
65                  70                  75                  80  


Arg Ala Lys Phe Leu Thr His Val Arg Cys His Met Glu Asp Val Gln 
                85                  90                  95      


Arg Ala Val Asp Thr Gly Val Asp Gly Leu Asp Leu Leu Phe Gly Thr 
            100                 105                 110         


Ser Ser Phe Leu Arg Glu Phe Ser His Gly Lys Ser Ile Ala Gln Ile 
        115                 120                 125             


Ile Asp Thr Ala Gly Glu Val Ile Gly Trp Ile Lys Thr His His Pro 
    130                 135                 140                 


Glu Leu Glu Ile Arg Phe Ser Ala Glu Asp Thr Phe Arg Ser Glu Glu 
145                 150                 155                 160 


Ala Asp Leu Met Ala Val Tyr Ser Ala Val Ser Glu Leu Gly Val His 
                165                 170                 175     


Arg Val Gly Leu Ala Asp Thr Val Gly Val Ala Thr Pro Arg Gln Val 
            180                 185                 190         


Tyr Thr Leu Val Arg Glu Val Arg Lys Val Ile His Glu Gly Cys Gly 
        195                 200                 205             


Ile Glu Phe His Gly His Asn Asp Thr Gly Cys Ala Val Ser Asn Ala 
    210                 215                 220                 


Tyr Glu Ala Ile Glu Ala Gly Ala Thr His Ile Asp Thr Thr Ile Leu 
225                 230                 235                 240 


Gly Ile Gly Glu Arg Asn Gly Ile Thr Pro Leu Gly Gly Leu Leu Ala 
                245                 250                 255     


Arg Met Phe Thr Phe Asp Pro Gln Gly Leu Ile Asp Lys Tyr Asn Leu 
            260                 265                 270         


Glu Leu Leu Pro Glu Leu Asp Arg Met Ile Ala Arg Met Val Asp Leu 
        275                 280                 285             


Pro Val Pro Trp Asn Asn Tyr Leu Thr Gly Glu Phe Ala Tyr Asn His 
    290                 295                 300                 


Lys Ala Gly Met His Leu Lys Ala Ile Tyr Leu Asn Pro Gly Ala Tyr 
305                 310                 315                 320 


Glu Ala Ile Pro Pro Gly Val Phe Gly Val Gly Arg Arg Ile Gln Ala 
                325                 330                 335     


Ala Ser Lys Val Thr Gly Lys His Ala Ile Ala Tyr Lys Ala Arg Glu 
            340                 345                 350         


Leu Gly Leu His Tyr Gly Glu Asp Ala Leu Arg Arg Val Thr Asp His 
        355                 360                 365             


Ile Lys Ser Leu Ala Glu Gln Asp Glu Leu Asp Asp Ala His Leu Glu 
    370                 375                 380                 


Gln Val Leu Arg Glu Trp Val Ser Ala 
385                 390             


<210>  71
<211>  389
<212>  PRT
<213>  Deinococcus geothermalis

<400>  71

Met Thr Pro Asp Ser Ser Thr Pro Leu Ile Pro Ala Arg Ser Trp Ala 
1               5                   10                  15      


Ile Ile Asp Ser Thr Leu Arg Glu Gly Glu Gln Phe Ala Arg Gly Asn 
            20                  25                  30          


Phe Lys Thr Gly Asp Lys Ile Glu Ile Ala Arg Leu Leu Asp Ala Phe 
        35                  40                  45              


Gly Ala Glu Phe Leu Glu Val Thr Thr Pro Met Val Gly Ala Gln Thr 
    50                  55                  60                  


Gln Ala Asp Ile Arg Arg Leu Thr Ser Leu Gly Leu Asn Ala Lys Ile 
65                  70                  75                  80  


Leu Thr His Val Arg Cys His Leu Glu Asp Val Gln Arg Ala Val Asp 
                85                  90                  95      


Leu Gly Val Asp Gly Leu Asp Leu Leu Phe Gly Thr Ser Ser Phe Leu 
            100                 105                 110         


Arg Glu Phe Ser His Gly Lys Ser Ile Ala Gln Ile Ile Asp Thr Ala 
        115                 120                 125             


Ser Glu Val Ile Gly Trp Ile Lys Gln Asn His Pro Asp Leu Glu Ile 
    130                 135                 140                 


Arg Phe Ser Ala Glu Asp Thr Phe Arg Ser Glu Glu Ala Asp Leu Met 
145                 150                 155                 160 


Ala Val Tyr Arg Ala Val Ser Asp Leu Gly Val His Arg Val Gly Leu 
                165                 170                 175     


Ala Asp Thr Val Gly Val Ala Thr Pro Arg Gln Val Tyr Thr Leu Val 
            180                 185                 190         


Arg Glu Val Arg Lys Val Ile His Ala Glu Cys Gly Ile Glu Phe His 
        195                 200                 205             


Gly His Asn Asp Thr Gly Cys Ala Val Ser Asn Ala Tyr Glu Ala Ile 
    210                 215                 220                 


Glu Ala Gly Ala Thr His Ile Asp Thr Thr Ile Leu Gly Ile Gly Glu 
225                 230                 235                 240 


Arg Asn Gly Ile Thr Pro Leu Gly Gly Phe Leu Ala Arg Met Phe Thr 
                245                 250                 255     


Phe Asp Pro Gln Gly Leu Ile Asp Lys Tyr Asn Leu Glu Leu Leu Pro 
            260                 265                 270         


Glu Leu Asp Arg Leu Ile Ala Arg Leu Val Asp Leu Pro Ile Pro Trp 
        275                 280                 285             


Asn Asn Tyr Leu Thr Gly Glu Phe Ala Tyr Asn His Lys Ala Gly Met 
    290                 295                 300                 


His Leu Lys Ala Ile Tyr Leu Asn Pro Gly Ala Tyr Glu Ala Ile Pro 
305                 310                 315                 320 


Pro Ser Val Phe Gly Val Gly Arg Arg Ile Gln Ala Ala Ser Lys Val 
                325                 330                 335     


Thr Gly Lys His Ala Ile Ala His Lys Ala Arg Glu Leu Gly Leu His 
            340                 345                 350         


Tyr Gly Glu Asp Ala Leu Arg Arg Val Thr Asp His Ile Lys Ala Leu 
        355                 360                 365             


Ala Glu Glu Gly Glu Leu Asp Asp Ala His Leu Glu Gln Val Leu Arg 
    370                 375                 380                 


Glu Trp Val Arg Ala 
385                 


<210>  72
<211>  553
<212>  PRT
<213>  Sulfolobus solfataricus

<400>  72

Met Ala Leu Lys Met Lys Tyr Asp Phe Leu Leu Leu Ser Leu Lys Leu 
1               5                   10                  15      


Leu Asn Leu Pro Ile Ile Phe His Leu Cys Ser Val Ser Lys Lys Ser 
            20                  25                  30          


Val Glu Val Leu Asp Thr Thr Leu Arg Asp Gly Ser Gln Gly Ala Asn 
        35                  40                  45              


Ile Ser Phe Thr Leu Asn Asp Lys Ile Lys Ile Ala Leu Leu Leu Asp 
    50                  55                  60                  


Glu Leu Gly Val Asp Tyr Ile Glu Gly Gly Trp Pro Gly Ser Asn Pro 
65                  70                  75                  80  


Lys Asp Glu Glu Phe Phe Arg Glu Ile Lys Lys Tyr Arg Leu Ser Lys 
                85                  90                  95      


Ala Lys Ile Ala Ala Phe Gly Ser Thr Lys Arg Lys Asp Val Ser Val 
            100                 105                 110         


Lys Glu Asp Ile Ser Leu Asn Ser Ile Val Lys Ala Asp Val Asp Val 
        115                 120                 125             


Ala Val Ile Phe Gly Lys Ser Trp Ser Leu His Ala Thr Glu Val Leu 
    130                 135                 140                 


Lys Val Thr Lys Gln Asp Asn Leu Asp Ile Val Tyr Asp Ser Ile Asn 
145                 150                 155                 160 


Tyr Leu Lys Ser His Gly Leu Lys Val Ile Phe Asp Ala Glu His Phe 
                165                 170                 175     


Tyr Gln Gly Phe Lys Glu Asp Pro Glu Tyr Ala Leu Glu Val Val Lys 
            180                 185                 190         


Thr Ala Glu Ser Ala Gly Ala Asp Val Ile Ala Leu Ala Asp Thr Asn 
        195                 200                 205             


Gly Gly Thr Pro Pro Phe Glu Val Tyr Glu Ile Thr Lys Lys Val Arg 
    210                 215                 220                 


Glu Val Leu Gln Val Lys Leu Gly Ile His Ala His Asn Asp Ile Gly 
225                 230                 235                 240 


Cys Ala Val Ala Asn Ser Leu Met Ala Ile Lys Ala Gly Ala Arg His 
                245                 250                 255     


Val Gln Gly Thr Ile Asn Gly Ile Gly Glu Arg Thr Gly Asn Ala Asp 
            260                 265                 270         


Leu Ile Gln Ile Ile Pro Thr Leu Ile Leu Lys Met Gly Leu Asn Ala 
        275                 280                 285             


Leu Asn Gly Gln Glu Ser Leu Arg Lys Leu Arg Glu Val Ser Arg Ile 
    290                 295                 300                 


Val Tyr Glu Ile Leu Gly Leu Pro Pro Asn Pro Tyr Gln Pro Tyr Val 
305                 310                 315                 320 


Gly Asp Asn Ala Phe Ala His Lys Ala Gly Val His Val Asp Ala Val 
                325                 330                 335     


Met Lys Val Pro Arg Ala Tyr Glu His Val Asp Pro Ser Leu Val Gly 
            340                 345                 350         


Asn Asp Arg Lys Phe Val Ile Ser Glu Leu Ser Gly Thr Ala Asn Leu 
        355                 360                 365             


Val Ser Tyr Leu Gln Gly Leu Gly Ile Ala Val Asp Lys Lys Asp Glu 
    370                 375                 380                 


Arg Leu Lys Lys Ala Leu Asn Lys Ile Lys Glu Leu Glu Ala Arg Gly 
385                 390                 395                 400 


Tyr Ser Phe Asp Val Gly Pro Ala Ser Ala Ile Leu Ile Thr Leu Lys 
                405                 410                 415     


Glu Leu Asn Ile Tyr Lys Asn Tyr Ile Asn Leu Glu Tyr Trp Lys Val 
            420                 425                 430         


Ile Asn Glu Asn Asn Gly Leu Ser Ile Gly Ile Val Lys Val Asn Ser 
        435                 440                 445             


Gln Leu Glu Val Ala Glu Gly Val Gly Pro Val Asn Ala Ile Asp Arg 
    450                 455                 460                 


Ala Leu Arg Met Ala Leu Gln Arg Val Tyr Pro Glu Ile Gly Glu Val 
465                 470                 475                 480 


Lys Leu Ile Asp Tyr Arg Val Ile Leu Pro Ser Glu Ile Lys Asn Thr 
                485                 490                 495     


Glu Ser Val Val Arg Val Thr Ile Glu Phe Thr Asp Asn Lys Met Asn 
            500                 505                 510         


Trp Arg Thr Glu Gly Val Ser Lys Ser Val Val Glu Ala Ser Val Met 
        515                 520                 525             


Ala Leu Val Asp Gly Leu Asp Tyr Tyr Leu Gln Leu Lys Lys Thr Leu 
    530                 535                 540                 


Lys Thr Ala Val Asp Asn Tyr Ile Val 
545                 550             


<210>  73
<211>  361
<212>  PRT
<213>  Thermococcus kodakarensis

<400>  73

Met Val Leu Asp Ser Thr Leu Arg Glu Gly Glu Gln Thr Pro Gly Val 
1               5                   10                  15      


Asn Phe Ser Pro Glu Asp Arg Leu Arg Ile Gly Ile Ala Leu Asp Glu 
            20                  25                  30          


Val Gly Val Asp Phe Ile Glu Ala Gly His Pro Ala Val Ser Gly Glu 
        35                  40                  45              


Ile Leu Glu Gly Ile Arg Leu Leu Ala Ser His Gly Leu Asn Ala Asn 
    50                  55                  60                  


Ile Leu Ala His Ser Arg Ala Leu Arg Ser Asp Ile Asp Leu Val Leu 
65                  70                  75                  80  


Lys Ala Glu Ala Glu Trp Ile Gly Ile Phe Met Cys Leu Ser Gln Arg 
                85                  90                  95      


Cys Leu Glu Arg Arg Phe Arg Thr Asp Leu Ser Gly Ala Leu Thr Arg 
            100                 105                 110         


Val Glu Asp Ala Ile Leu Tyr Ala Lys Asp His Gly Leu Lys Ile Arg 
        115                 120                 125             


Phe Thr Pro Glu Asp Thr Thr Arg Thr Glu Trp Lys Asn Leu Thr Ala 
    130                 135                 140                 


Ala Leu Asn Leu Ala Arg Glu Leu Lys Val Asp Arg Val Ser Ile Ala 
145                 150                 155                 160 


Asp Thr Thr Gly Ala Ala His Pro Leu Glu Phe Tyr Asp Leu Val Lys 
                165                 170                 175     


Arg Val Val Glu Phe Gly Ile Pro Val Asn Val His Cys His Asn Asp 
            180                 185                 190         


Leu Gly Leu Ala Leu Ala Asn Ala Ile Met Gly Ile Glu Ala Gly Ala 
        195                 200                 205             


Thr Leu Val Asp Ala Thr Val Asn Gly Ile Gly Glu Arg Ala Gly Ile 
    210                 215                 220                 


Val Asp Leu Ser His Leu Leu Ala Ala Leu Tyr Tyr His Tyr Gly Val 
225                 230                 235                 240 


Lys Lys Tyr Arg Leu Glu Lys Leu Tyr Ser Leu Ser Arg Leu Val Ser 
                245                 250                 255     


Glu Ile Thr Gly Leu Gln Val Gln Val Asn Tyr Pro Ile Val Gly Gln 
            260                 265                 270         


Asn Ala Phe Thr His Lys Ala Gly Leu His Val Ser Ala Val Val Arg 
        275                 280                 285             


Asp Pro Ser Phe Tyr Glu Phe Leu Pro Ala Glu Thr Phe Gly Arg Glu 
    290                 295                 300                 


Arg Thr Ile Tyr Val Asp Arg Phe Ala Gly Arg Glu Thr Ile Arg Phe 
305                 310                 315                 320 


His Leu Ser Arg Phe Gly Ile His Asp Glu Glu Ile Ile Glu Glu Leu 
                325                 330                 335     


Leu Arg Arg Val Lys Ala Ser Arg Arg Pro Phe Thr Pro Glu Met Leu 
            340                 345                 350         


Ala Glu Glu Ala Arg Arg Met Met Thr 
        355                 360     


<210>  74
<211>  361
<212>  PRT
<213>  Pyrococcus horikoshii

<400>  74

Met Ile Leu Asp Ser Thr Leu Arg Glu Gly Glu Gln Thr Pro Gly Val 
1               5                   10                  15      


Asn Tyr Ser Pro Glu Gln Arg Leu Arg Ile Ala Leu Ala Leu Asp Glu 
            20                  25                  30          


Ile Gly Val Asp Phe Ile Glu Val Gly His Pro Ala Val Ser Lys Asp 
        35                  40                  45              


Val Phe Ile Gly Ile Lys Leu Ile Ala Ser Gln Asp Leu Asn Ala Asn 
    50                  55                  60                  


Leu Leu Ala His Ser Arg Ala Leu Leu Glu Asp Ile Asp Tyr Val Ile 
65                  70                  75                  80  


Gln Ala Asp Val Glu Trp Val Gly Ile Phe Phe Cys Leu Ser Asn Ala 
                85                  90                  95      


Cys Leu Arg Lys Arg Phe Arg Met Ser Leu Ser Gln Ala Leu Glu Arg 
            100                 105                 110         


Ile Ser Lys Ala Ile Glu Tyr Ala Lys Asp His Gly Leu Lys Val Arg 
        115                 120                 125             


Phe Thr Pro Glu Asp Thr Thr Arg Thr Glu Trp Glu Asn Leu Arg Arg 
    130                 135                 140                 


Ala Ile Glu Leu Ala Lys Glu Leu Lys Val Asp Arg Ile Ser Val Ala 
145                 150                 155                 160 


Asp Thr Thr Gly Gly Thr His Pro Leu Arg Phe Tyr Thr Leu Val Lys 
                165                 170                 175     


Lys Val Val Asn Phe Gly Ile Pro Val Asn Val His Cys His Asn Asp 
            180                 185                 190         


Leu Gly Leu Ala Leu Ala Asn Ala Ile Met Gly Ile Glu Gly Gly Ala 
        195                 200                 205             


Thr Val Val Asp Ala Thr Val Asn Gly Leu Gly Glu Arg Ala Gly Ile 
    210                 215                 220                 


Val Asp Leu Ala Gln Ile Val Thr Val Leu Tyr Tyr His Tyr Gly Val 
225                 230                 235                 240 


Lys Lys Tyr Arg Leu Asp Lys Leu Tyr Glu Ile Ser Arg Met Val Ser 
                245                 250                 255     


Glu Ile Thr Gly Ile Ala Leu Gln Pro Asn Tyr Pro Ile Val Gly Glu 
            260                 265                 270         


Asn Ala Phe Thr His Lys Ala Gly Leu His Val Ser Ala Val Leu Lys 
        275                 280                 285             


Asp Pro Arg Phe Tyr Glu Phe Leu Pro Ala Glu Val Phe Gly Arg Glu 
    290                 295                 300                 


Arg Thr Ile Tyr Val Asp Arg Phe Ala Gly Lys Asp Thr Ile Arg Tyr 
305                 310                 315                 320 


Tyr Leu Gln Lys Leu Gly Ile Asn Asp Glu Glu Phe Val Lys Val Leu 
                325                 330                 335     


Leu Lys Arg Val Lys Ser Ser Arg Glu Pro Phe Thr Trp Asp Lys Phe 
            340                 345                 350         


Ile Glu Glu Val Arg Arg Leu Lys Thr 
        355                 360     


<210>  75
<211>  385
<212>  PRT
<213>  Azotobacter vinelandii

<400>  75

Met Ala Ser Val Ile Ile Asp Asp Thr Thr Leu Arg Asp Gly Glu Gln 
1               5                   10                  15      


Ser Ala Gly Val Ala Phe Asn Ala Asp Glu Lys Ile Ala Ile Ala Arg 
            20                  25                  30          


Ala Leu Ala Glu Leu Gly Val Pro Glu Leu Glu Ile Gly Ile Pro Ser 
        35                  40                  45              


Met Gly Glu Glu Glu Arg Glu Val Met His Ala Ile Ala Gly Leu Gly 
    50                  55                  60                  


Leu Ser Ser Arg Leu Leu Ala Trp Cys Arg Leu Cys Asp Val Asp Leu 
65                  70                  75                  80  


Ala Ala Ala Arg Ser Thr Gly Val Thr Met Val Asp Leu Ser Leu Pro 
                85                  90                  95      


Val Ser Asp Leu Met Leu His His Lys Leu Asn Arg Asp Arg Asp Trp 
            100                 105                 110         


Ala Leu Arg Glu Val Ala Arg Leu Val Gly Glu Ala Arg Met Ala Gly 
        115                 120                 125             


Leu Glu Val Cys Leu Gly Cys Glu Asp Ala Ser Arg Ala Asp Leu Glu 
    130                 135                 140                 


Phe Val Val Gln Val Gly Glu Val Ala Gln Ala Ala Gly Ala Arg Arg 
145                 150                 155                 160 


Leu Arg Phe Ala Asp Thr Val Gly Val Met Glu Pro Phe Gly Met Leu 
                165                 170                 175     


Asp Arg Phe Arg Phe Leu Ser Arg Arg Leu Asp Met Glu Leu Glu Val 
            180                 185                 190         


His Ala His Asp Asp Phe Gly Leu Ala Thr Ala Asn Thr Leu Ala Ala 
        195                 200                 205             


Val Met Gly Gly Ala Thr His Ile Asn Thr Thr Val Asn Gly Leu Gly 
    210                 215                 220                 


Glu Arg Ala Gly Asn Ala Ala Leu Glu Glu Cys Val Leu Ala Leu Lys 
225                 230                 235                 240 


Asn Leu His Gly Ile Asp Thr Gly Ile Asp Thr Arg Gly Ile Pro Ala 
                245                 250                 255     


Ile Ser Ala Leu Val Glu Arg Ala Ser Gly Arg Gln Val Ala Trp Gln 
            260                 265                 270         


Lys Ser Val Val Gly Ala Gly Val Phe Thr His Glu Ala Gly Ile His 
        275                 280                 285             


Val Asp Gly Leu Leu Lys His Arg Arg Asn Tyr Glu Gly Leu Asn Pro 
    290                 295                 300                 


Asp Glu Leu Gly Arg Ser His Ser Leu Val Leu Gly Lys His Ser Gly 
305                 310                 315                 320 


Ala His Met Val Arg Asn Thr Tyr Arg Asp Leu Gly Ile Glu Leu Ala 
                325                 330                 335     


Asp Trp Gln Ser Gln Ala Leu Leu Gly Arg Ile Arg Ala Phe Ser Thr 
            340                 345                 350         


Arg Thr Lys Arg Arg Ser Pro Gln Pro Ala Glu Leu Gln Asp Phe Tyr 
        355                 360                 365             


Arg Gln Leu Cys Glu Gln Gly Asn Pro Glu Leu Ala Ala Gly Gly Met 
    370                 375                 380                 


Ala 
385 


<210>  76
<211>  381
<212>  PRT
<213>  Klebsiella pneumoniae

<400>  76

Met Glu Arg Val Leu Ile Asn Asp Thr Thr Leu Arg Asp Gly Glu Gln 
1               5                   10                  15      


Ser Pro Gly Val Ala Phe Arg Thr Ser Glu Lys Val Ala Ile Ala Glu 
            20                  25                  30          


Ala Leu Tyr Ala Ala Gly Ile Thr Ala Met Glu Val Gly Thr Pro Ala 
        35                  40                  45              


Met Gly Asp Glu Glu Ile Ala Arg Ile Gln Leu Val Arg Arg Gln Leu 
    50                  55                  60                  


Pro Asp Ala Thr Leu Met Thr Trp Cys Arg Met Asn Ala Leu Glu Ile 
65                  70                  75                  80  


Arg Gln Ser Ala Asp Leu Gly Ile Asp Trp Val Asp Ile Ser Ile Pro 
                85                  90                  95      


Ala Ser Asp Lys Leu Arg Gln Tyr Lys Leu Arg Glu Pro Leu Ala Val 
            100                 105                 110         


Leu Leu Glu Arg Leu Ala Met Phe Ile His Leu Ala His Thr Leu Gly 
        115                 120                 125             


Leu Lys Val Cys Ile Gly Cys Glu Asp Ala Ser Arg Ala Ser Gly Gln 
    130                 135                 140                 


Thr Leu Arg Ala Ile Ala Glu Val Ala Gln Asn Ala Pro Ala Ala Arg 
145                 150                 155                 160 


Leu Arg Tyr Ala Asp Thr Val Gly Leu Leu Asp Pro Phe Thr Thr Ala 
                165                 170                 175     


Ala Gln Ile Ser Ala Leu Arg Asp Val Trp Ser Gly Glu Ile Glu Met 
            180                 185                 190         


His Ala His Asn Asp Leu Gly Met Ala Thr Ala Asn Thr Leu Ala Ala 
        195                 200                 205             


Val Ser Ala Gly Ala Thr Ser Val Asn Thr Thr Val Leu Gly Leu Gly 
    210                 215                 220                 


Glu Arg Ala Gly Asn Ala Ala Ala Trp Lys Pro Ser Ala Leu Gly Leu 
225                 230                 235                 240 


Glu Arg Cys Leu Gly Val Glu Thr Gly Val His Phe Ser Ala Leu Pro 
                245                 250                 255     


Ala Leu Cys Gln Arg Val Ala Glu Ala Ala Gln Arg Ala Ile Asp Pro 
            260                 265                 270         


Gln Gln Pro Leu Val Gly Glu Leu Val Phe Thr His Glu Ser Gly Val 
        275                 280                 285             


His Val Ala Ala Leu Leu Arg Asp Ser Glu Ser Tyr Gln Ser Ile Ala 
    290                 295                 300                 


Pro Ser Leu Met Gly Arg Ser Tyr Arg Leu Val Leu Gly Lys His Ser 
305                 310                 315                 320 


Gly Arg Gln Ala Val Asn Gly Val Phe Asp Gln Met Gly Tyr His Leu 
                325                 330                 335     


Asn Ala Ala Gln Ile Asn Gln Leu Leu Pro Ala Ile Arg Arg Phe Ala 
            340                 345                 350         


Glu Asn Trp Lys Arg Ser Pro Lys Asp Tyr Glu Leu Val Ala Ile Tyr 
        355                 360                 365             


Asp Glu Leu Cys Gly Glu Ser Ala Leu Arg Ala Arg Gly 
    370                 375                 380     


<210>  77
<211>  381
<212>  PRT
<213>  Pseudomonas stutzeri

<400>  77

Met Ser Ile Val Ile Asp Asp Thr Thr Leu Arg Asp Gly Glu Gln Ser 
1               5                   10                  15      


Ala Gly Val Ala Phe Ser Ala Glu Glu Lys Leu Ala Ile Ala Arg Ala 
            20                  25                  30          


Leu Ala Gln Leu Gly Val Pro Glu Leu Glu Ile Gly Ile Pro Ser Met 
        35                  40                  45              


Gly Glu Glu Glu Cys Glu Val Met Arg Ala Ile Ala Gly Leu Ala Leu 
    50                  55                  60                  


Pro Val Arg Leu Leu Ala Trp Cys Arg Leu Cys Asp Ala Asp Leu Leu 
65                  70                  75                  80  


Ala Ala Gly Gly Thr Gly Val Gly Met Val Asp Leu Ser Leu Pro Val 
                85                  90                  95      


Ser Asp Leu Met Leu Gln His Lys Leu Gly Arg Asp Arg Asp Trp Ala 
            100                 105                 110         


Leu Arg Glu Ala Ala Arg Leu Val Gly Ala Ala Arg Asp Ala Gly Leu 
        115                 120                 125             


Glu Val Cys Leu Gly Cys Glu Asp Ala Ser Arg Ala Asp Pro Glu Phe 
    130                 135                 140                 


Ile Val Arg Val Ala Glu Val Ala Gln Ala Ala Gly Ala Arg Arg Leu 
145                 150                 155                 160 


Arg Phe Ala Asp Thr Val Gly Val Met Glu Pro Phe Ala Met His Ala 
                165                 170                 175     


Arg Phe Arg Phe Leu Ala Glu Arg Leu Asp Leu Glu Leu Glu Val His 
            180                 185                 190         


Ala His Asp Asp Phe Gly Leu Ala Thr Ala Asn Thr Leu Ala Ala Val 
        195                 200                 205             


Arg Gly Gly Ala Thr His Ile Asn Thr Thr Val Asn Gly Leu Gly Glu 
    210                 215                 220                 


Arg Ala Gly Asn Ala Ala Leu Glu Glu Cys Ala Leu Ala Leu Lys His 
225                 230                 235                 240 


Leu His Gly Ile Asp Cys Gly Ile Asp Val Arg Gly Ile Pro Ser Ile 
                245                 250                 255     


Ser Ala Leu Val Glu Gln Ala Ser Gly Arg Gln Val Ala Trp Gln Lys 
            260                 265                 270         


Ser Val Val Gly Ala Gly Val Phe Thr His Glu Ala Gly Ile His Val 
        275                 280                 285             


Asp Gly Leu Leu Lys His Arg Arg Asn Tyr Glu Gly Leu Asn Pro Asp 
    290                 295                 300                 


Glu Leu Gly Arg Ser His Ser Leu Val Leu Gly Lys His Ser Gly Ala 
305                 310                 315                 320 


His Met Val Glu Leu Ser Tyr Arg Glu Leu Gly Ile Glu Leu Gln Gln 
                325                 330                 335     


Trp Gln Ser Arg Ala Leu Leu Gly Cys Ile Arg Arg Phe Ser Thr Gln 
            340                 345                 350         


Thr Lys Arg Ser Pro Gln Ser Ala Asp Leu Gln Gly Phe Tyr Gln Gln 
        355                 360                 365             


Leu Cys Glu Gln Gly Leu Ala Leu Ala Gly Gly Ala Ala 
    370                 375                 380     


<210>  78
<211>  477
<212>  PRT
<213>  Acinetobacter sp.

<400>  78

Met Asn Tyr Pro Asn Ile Pro Leu Tyr Ile Asn Gly Glu Phe Leu Asp 
1               5                   10                  15      


His Thr Asn Arg Asp Val Lys Glu Val Phe Asn Pro Val Asn His Glu 
            20                  25                  30          


Cys Ile Gly Leu Met Ala Cys Ala Ser Gln Ala Asp Leu Asp Tyr Ala 
        35                  40                  45              


Leu Glu Ser Ser Gln Gln Ala Phe Leu Arg Trp Lys Lys Thr Ser Pro 
    50                  55                  60                  


Ile Thr Arg Ser Glu Ile Leu Arg Thr Phe Ala Lys Leu Ala Arg Glu 
65                  70                  75                  80  


Lys Ala Ala Glu Ile Gly Arg Asn Ile Thr Leu Asp Gln Gly Lys Pro 
                85                  90                  95      


Leu Lys Glu Ala Ile Ala Glu Val Thr Val Cys Ala Glu His Ala Glu 
            100                 105                 110         


Trp His Ala Glu Glu Cys Arg Arg Ile Tyr Gly Arg Val Ile Pro Pro 
        115                 120                 125             


Arg Asn Pro Asn Val Gln Gln Leu Val Val Arg Glu Pro Leu Gly Val 
    130                 135                 140                 


Cys Leu Ala Phe Ser Pro Trp Asn Phe Pro Phe Asn Gln Ala Ile Arg 
145                 150                 155                 160 


Lys Ile Ser Ala Ala Ile Ala Ala Gly Cys Thr Ile Ile Val Lys Gly 
                165                 170                 175     


Ser Gly Asp Thr Pro Ser Ala Val Tyr Ala Ile Ala Gln Leu Phe His 
            180                 185                 190         


Glu Ala Gly Leu Pro Asn Gly Val Leu Asn Val Ile Trp Gly Asp Ser 
        195                 200                 205             


Asn Phe Ile Ser Asp Tyr Met Ile Lys Ser Pro Ile Ile Gln Lys Ile 
    210                 215                 220                 


Ser Phe Thr Gly Ser Thr Pro Val Gly Lys Lys Leu Ala Ser Gln Ala 
225                 230                 235                 240 


Ser Leu Tyr Met Lys Pro Cys Thr Met Glu Leu Gly Gly His Ala Pro 
                245                 250                 255     


Val Ile Val Cys Asp Asp Ala Asp Ile Asp Ala Ala Val Glu His Leu 
            260                 265                 270         


Val Gly Tyr Lys Phe Arg Asn Ala Gly Gln Val Cys Val Ser Pro Thr 
        275                 280                 285             


Arg Phe Tyr Val Gln Glu Gly Ile Tyr Lys Glu Phe Ser Glu Lys Val 
    290                 295                 300                 


Val Leu Arg Ala Lys Gln Ile Lys Val Gly Cys Gly Leu Asp Ala Ser 
305                 310                 315                 320 


Ser Asp Met Gly Pro Leu Ala Gln Ala Arg Arg Met His Ala Met Gln 
                325                 330                 335     


Gln Ile Val Glu Asp Ala Val His Lys Gly Ser Lys Leu Leu Leu Gly 
            340                 345                 350         


Gly Asn Lys Ile Ser Asp Lys Gly Asn Phe Phe Glu Pro Thr Val Leu 
        355                 360                 365             


Gly Asp Leu Cys Asn Asp Thr Gln Phe Met Asn Asp Glu Pro Phe Gly 
    370                 375                 380                 


Pro Ile Ile Gly Leu Ile Pro Phe Asp Thr Ile Asp His Val Leu Glu 
385                 390                 395                 400 


Glu Ala Asn Arg Leu Pro Phe Gly Leu Ala Ser Tyr Ala Phe Thr Thr 
                405                 410                 415     


Ser Ser Lys Asn Ala His Gln Ile Ser Tyr Gly Leu Glu Ala Gly Met 
            420                 425                 430         


Val Ser Ile Asn His Met Gly Leu Ala Leu Ala Glu Thr Pro Phe Gly 
        435                 440                 445             


Gly Ile Lys Asp Ser Gly Phe Gly Ser Glu Gly Gly Ile Glu Thr Phe 
    450                 455                 460                 


Asp Gly Tyr Leu Arg Thr Lys Phe Ile Thr Gln Leu Asn 
465                 470                 475         


<210>  79
<211>  473
<212>  PRT
<213>  Brucella melitensis

<400>  79

Met Arg Ile Gly Lys Met Glu Met Gln Thr Arg Tyr Pro Asp Val Lys 
1               5                   10                  15      


Leu Phe Ile Asp Gly Thr Trp Arg Asp Gly Ser Arg Gly Glu Thr Ile 
            20                  25                  30          


Glu Ile Phe Asn Pro Ala Thr Asp Glu Val Ile Gly His Ile Ala Arg 
        35                  40                  45              


Ala Thr Thr Ala Asp Leu Asp Asp Ala Leu Ala Ala Val Asp Arg Gly 
    50                  55                  60                  


Phe Glu Ala Trp Ser Lys Val Ser Ala Phe Asp Arg Tyr Lys Ile Met 
65                  70                  75                  80  


Arg Arg Ala Ala Asp Ile Phe Arg Ser Arg Gly Glu Glu Val Ala Arg 
                85                  90                  95      


Leu Leu Thr Met Glu Gln Gly Lys Pro Leu Ala Glu Ala Arg Ile Glu 
            100                 105                 110         


Ala Ala Ala Ala Cys Asp Leu Ile Asp Trp Phe Ala Glu Glu Ala Arg 
        115                 120                 125             


Arg Ser Tyr Gly Arg Ile Val Pro Pro Arg Gln Ala Tyr Val Met Gln 
    130                 135                 140                 


Ala Glu Val Lys Glu Pro Val Gly Pro Val Ala Ala Phe Thr Pro Trp 
145                 150                 155                 160 


Asn Phe Pro Ile Asn Gln Ala Val Arg Lys Ile Ser Ala Ala Leu Ala 
                165                 170                 175     


Ala Gly Cys Ser Ile Leu Leu Lys Ala Ala Glu Asp Thr Pro Ala Ala 
            180                 185                 190         


Pro Ala Glu Leu Val Arg Ala Phe Ala Glu Ala Gly Leu Pro Asp Gly 
        195                 200                 205             


Ala Ile Asn Leu Val Tyr Gly Asp Pro Ala Glu Ile Ser Ala Tyr Leu 
    210                 215                 220                 


Ile Pro His Pro Val Ile Arg Lys Val Ser Phe Thr Gly Ser Thr Gln 
225                 230                 235                 240 


Val Gly Lys Gln Leu Ala Ala Leu Ala Gly Leu His Met Lys Arg Val 
                245                 250                 255     


Thr Met Glu Leu Gly Gly His Ala Pro Val Ile Ile Ala Ala Asp Ala 
            260                 265                 270         


Asp Val Glu Gln Ala Ile Lys Val Val Ser Gly Ser Lys Phe Arg Asn 
        275                 280                 285             


Ala Gly Gln Val Cys Ile Ser Pro Thr Arg Phe Leu Ile Glu Asn Ser 
    290                 295                 300                 


Val Tyr Asp Gln Val Val Glu Gly Met Ala Ala Tyr Ala Thr Ser Leu 
305                 310                 315                 320 


Lys Val Gly Asp Gly Leu Glu Ala Gly Thr Thr Met Gly Pro Leu Val 
                325                 330                 335     


Asn Ala Lys Arg Val Asn Ala Met Glu Arg Leu Val Gln Asp Ala Arg 
            340                 345                 350         


Glu His Lys Ala Arg Val Val Thr Gly Gly Glu Arg Ile Gly Asn Arg 
        355                 360                 365             


Gly Asn Phe Phe Glu Pro Thr Ile Leu Ala Asp Val Pro Arg Asp Ala 
    370                 375                 380                 


Ala Ile Met Asn Glu Glu Pro Phe Gly Pro Val Ala Leu Leu Asn Arg 
385                 390                 395                 400 


Phe Asp Ala Leu Asp Glu Ala Leu Ser Glu Ala Asn Arg Leu Asn Tyr 
                405                 410                 415     


Gly Leu Ala Ala Tyr Ala Phe Thr Gly Ser Ser Ala Lys Ala Ala Arg 
            420                 425                 430         


Ile Ser Ser Thr Val Arg Ser Gly Met Ile Thr Ile Asn Gln Leu Arg 
        435                 440                 445             


Ser Gly Pro Ala Gly Ser Ala Leu Arg Arg Asp Gln Arg Phe Arg Leu 
    450                 455                 460                 


Trp Asn Gly Arg Arg Cys Arg Arg Ala 
465                 470             


<210>  80
<211>  530
<212>  PRT
<213>  Acinetobacter baumannii

<400>  80

Met Arg Leu Ile Met Leu Asn Ile Thr Gly Gln Asn Phe Ile Ala Gly 
1               5                   10                  15      


Gln Arg Ser Ser Ala Gly Ser Lys Phe Val Leu Ser Tyr Asp Ala Ala 
            20                  25                  30          


Thr Asp Glu Ala Leu Pro Tyr Gln Phe Ala Gln Ala Thr Pro Glu Glu 
        35                  40                  45              


Ile Asp Gln Ala Ala Gln Ala Ala Ala Leu Ala Tyr Pro Ala Phe Arg 
    50                  55                  60                  


Gln Thr Thr Pro Glu Gln Arg Ala Val Phe Leu Glu Thr Ile Ala Ser 
65                  70                  75                  80  


Glu Ile Asp Ala Leu Asp Asp Gln Phe Ile Ala Thr Val Cys Gln Glu 
                85                  90                  95      


Thr Ala Leu Pro Glu Ala Arg Ile Arg Gly Glu Arg Gly Arg Thr Thr 
            100                 105                 110         


Gly Gln Leu Arg Leu Phe Ala Gln Val Leu Arg Arg Gly Asp Tyr Leu 
        115                 120                 125             


Gly Ala Arg Ile Asp Leu Ala Leu Pro Glu Arg Gln Pro Leu Pro Arg 
    130                 135                 140                 


Pro Asp Leu Arg Gln Tyr Lys Ile Gly Val Gly Pro Val Ala Val Phe 
145                 150                 155                 160 


Gly Ala Ser Asn Phe Pro Leu Ala Phe Ser Thr Ala Gly Gly Asp Thr 
                165                 170                 175     


Ala Ser Ala Leu Ala Ala Gly Cys Pro Val Ile Val Lys Ala His Ser 
            180                 185                 190         


Gly His Met Ala Thr Ala Glu Ser Ile Ala Asn Ala Ile Cys Ser Ala 
        195                 200                 205             


Ile Glu Lys Cys Ala Met Pro Lys Gly Ile Phe Ser Met Ile Tyr Gly 
    210                 215                 220                 


Gln Gly Val Gly Glu Pro Leu Val Lys His Pro Ala Ile Lys Ala Val 
225                 230                 235                 240 


Gly Phe Thr Gly Ser Leu Lys Gly Gly Arg Ala Leu Cys Asp Leu Ala 
                245                 250                 255     


Ala Ala Arg Pro Glu Pro Ile Pro Val Phe Ala Glu Met Ser Ser Ile 
            260                 265                 270         


Asn Pro Met Ile Leu Leu Pro Glu Ala Leu Lys Val Arg Gly Asp Lys 
        275                 280                 285             


Ile Ala Thr Glu Leu Ser Gly Ser Val Val Leu Gly Cys Gly Gln Phe 
    290                 295                 300                 


Cys Thr Asn Pro Gly Leu Ile Ile Gly Ile Lys Ser Pro Glu Phe Ser 
305                 310                 315                 320 


Gln Phe Leu Asp His Phe Lys Ala Ala Met Ala Gln Gln Pro Pro Gln 
                325                 330                 335     


Thr Met Leu Asn Lys Gly Thr Leu Arg Ser Tyr Glu His Gly Leu Lys 
            340                 345                 350         


Glu Leu Leu Ala His Asp Lys Ile Glu His Leu Ala Gly Gln Pro Gln 
        355                 360                 365             


Gln Gly Pro Gln Ala Tyr Pro Gln Leu Phe Lys Ala Asp Val Ser Leu 
    370                 375                 380                 


Leu Leu Glu His Asp Glu Phe Leu Gln Glu Glu Val Phe Gly Pro Thr 
385                 390                 395                 400 


Thr Ile Val Ile Glu Val Glu Ser Ala Glu Gln Leu Ala Leu Ala Leu 
                405                 410                 415     


Asn Gly Leu Arg Gly Gln Leu Thr Ala Ser Leu Ile Ala Glu Pro Gln 
            420                 425                 430         


Asp Phe Glu Asn Phe Ala Thr Leu Ile Pro Leu Leu Glu Glu Lys Ala 
        435                 440                 445             


Gly Arg Leu Leu Leu Asn Gly Tyr Pro Thr Gly Val Glu Val Cys Asp 
    450                 455                 460                 


Ala Met Val His Gly Gly Pro Tyr Pro Ala Thr Ser Asp Ala Arg Gly 
465                 470                 475                 480 


Thr Ser Val Gly Thr Leu Ala Ile Glu Arg Tyr Leu Arg Pro Val Cys 
                485                 490                 495     


Tyr Gln Asn Tyr Pro Asp His Leu Leu Pro Leu Ala Leu Gln Asn Ala 
            500                 505                 510         


Asn Pro Leu Gly Ile Ala Arg Leu Val Asn Gly Glu Met Ser Lys Ala 
        515                 520                 525             


Ala Leu 
    530 


<210>  81
<211>  481
<212>  PRT
<213>  Azospirillum brasilense

<400>  81

Met Ala Asn Val Thr Tyr Thr Asp Thr Gln Leu Leu Ile Asp Gly Glu 
1               5                   10                  15      


Trp Val Asp Ala Ala Ser Gly Lys Thr Ile Asp Val Val Asn Pro Ala 
            20                  25                  30          


Thr Gly Lys Pro Ile Gly Arg Val Ala His Ala Gly Ile Ala Asp Leu 
        35                  40                  45              


Asp Arg Ala Leu Ala Ala Ala Gln Ser Gly Phe Glu Ala Trp Arg Lys 
    50                  55                  60                  


Val Pro Ala His Glu Arg Ala Ala Thr Met Arg Lys Ala Ala Ala Leu 
65                  70                  75                  80  


Val Arg Glu Arg Ala Asp Ala Ile Ala Gln Leu Met Thr Gln Glu Gln 
                85                  90                  95      


Gly Lys Pro Leu Thr Glu Ala Arg Val Glu Val Leu Ser Ala Ala Asp 
            100                 105                 110         


Ile Ile Glu Trp Phe Ala Asp Glu Gly Arg Arg Val Tyr Gly Arg Ile 
        115                 120                 125             


Val Pro Pro Arg Asn Leu Gly Ala Gln Gln Thr Val Val Lys Glu Pro 
    130                 135                 140                 


Val Gly Pro Val Ala Ala Phe Thr Pro Trp Asn Phe Pro Val Asn Gln 
145                 150                 155                 160 


Val Val Arg Lys Leu Ser Ala Ala Leu Ala Thr Gly Cys Ser Phe Leu 
                165                 170                 175     


Val Lys Ala Pro Glu Glu Thr Pro Ala Ser Pro Ala Ala Leu Leu Arg 
            180                 185                 190         


Ala Phe Val Asp Ala Gly Val Pro Ala Gly Val Ile Gly Leu Val Tyr 
        195                 200                 205             


Gly Asp Pro Ala Glu Ile Ser Ser Tyr Leu Ile Pro His Pro Val Ile 
    210                 215                 220                 


Arg Lys Val Thr Phe Thr Gly Ser Thr Pro Val Gly Lys Gln Leu Ala 
225                 230                 235                 240 


Ser Leu Ala Gly Leu His Met Lys Arg Ala Thr Met Glu Leu Gly Gly 
                245                 250                 255     


His Ala Pro Val Ile Val Ala Glu Asp Ala Asp Val Ala Leu Ala Val 
            260                 265                 270         


Lys Ala Ala Gly Gly Ala Lys Phe Arg Asn Ala Gly Gln Val Cys Ile 
        275                 280                 285             


Ser Pro Thr Arg Phe Leu Val His Asn Ser Ile Arg Asp Glu Phe Thr 
    290                 295                 300                 


Arg Ala Leu Val Lys His Ala Glu Gly Leu Lys Val Gly Asn Gly Leu 
305                 310                 315                 320 


Glu Glu Gly Thr Thr Leu Gly Ala Leu Ala Asn Pro Arg Arg Leu Thr 
                325                 330                 335     


Ala Met Ala Ser Val Ile Asp Asn Ala Arg Lys Val Gly Ala Ser Ile 
            340                 345                 350         


Glu Thr Gly Gly Glu Arg Ile Gly Ser Glu Gly Asn Phe Phe Ala Pro 
        355                 360                 365             


Thr Val Ile Ala Asn Val Pro Leu Asp Ala Asp Val Phe Asn Asn Glu 
    370                 375                 380                 


Pro Phe Gly Pro Val Ala Ala Ile Arg Gly Phe Asp Lys Leu Glu Glu 
385                 390                 395                 400 


Ala Ile Ala Glu Ala Asn Arg Leu Pro Phe Gly Leu Ala Gly Tyr Ala 
                405                 410                 415     


Phe Thr Arg Ser Phe Ala Asn Val His Leu Leu Thr Gln Arg Leu Glu 
            420                 425                 430         


Val Gly Met Leu Trp Ile Asn Gln Pro Ala Thr Pro Trp Pro Glu Met 
        435                 440                 445             


Pro Phe Gly Gly Val Lys Asp Ser Gly Tyr Gly Ser Glu Gly Gly Pro 
    450                 455                 460                 


Glu Ala Leu Glu Pro Tyr Leu Val Thr Lys Ser Val Thr Val Met Ala 
465                 470                 475                 480 


Val 
    


<210>  82
<211>  1350
<212>  DNA
<213>  Bacillus weihenstephanensis


<220>
<221>  CDS
<222>  (1)..(1350)

<400>  82
gtg caa gcg acg gag caa aca caa agt ttg aaa aaa aca gat gaa aag       48
Val Gln Ala Thr Glu Gln Thr Gln Ser Leu Lys Lys Thr Asp Glu Lys         
1               5                   10                  15              

tac ctt tgg cat gcg atg aga gga gca gcc cct agt cca acg aat tta       96
Tyr Leu Trp His Ala Met Arg Gly Ala Ala Pro Ser Pro Thr Asn Leu         
            20                  25                  30                  

att atc aca aaa gca gaa ggg gca tgg gtg acg gat att gat gga aac      144
Ile Ile Thr Lys Ala Glu Gly Ala Trp Val Thr Asp Ile Asp Gly Asn         
        35                  40                  45                      

cgt tat tta gac ggt atg tcc ggt ctt tgg tgc gtg aat gtt ggg tat      192
Arg Tyr Leu Asp Gly Met Ser Gly Leu Trp Cys Val Asn Val Gly Tyr         
    50                  55                  60                          

ggt cga aaa gaa ctt gca aga gcg gcg ttt gaa cag ctt gaa gaa atg      240
Gly Arg Lys Glu Leu Ala Arg Ala Ala Phe Glu Gln Leu Glu Glu Met         
65                  70                  75                  80          

ccg tat ttc cct ctg act caa agt cat gtt cct gct att aaa tta gca      288
Pro Tyr Phe Pro Leu Thr Gln Ser His Val Pro Ala Ile Lys Leu Ala         
                85                  90                  95              

gaa aaa ttg aat gaa tgg ctt gat gat gaa tac gtc att ttc ttt tct      336
Glu Lys Leu Asn Glu Trp Leu Asp Asp Glu Tyr Val Ile Phe Phe Ser         
            100                 105                 110                 

aac agt gga tcg gaa gcg aat gaa aca gca ttt aaa att gct cgt caa      384
Asn Ser Gly Ser Glu Ala Asn Glu Thr Ala Phe Lys Ile Ala Arg Gln         
        115                 120                 125                     

tat cat caa caa aaa ggt gat cat gga cgc tat aag ttt att tcc cgc      432
Tyr His Gln Gln Lys Gly Asp His Gly Arg Tyr Lys Phe Ile Ser Arg         
    130                 135                 140                         

tac cgc gct tat cac ggt aac tca atg gga gct ctt gca gca aca ggt      480
Tyr Arg Ala Tyr His Gly Asn Ser Met Gly Ala Leu Ala Ala Thr Gly         
145                 150                 155                 160         

caa gca cag cga aag tat aaa tat gaa cca ctc ggg caa gga ttc ctg      528
Gln Ala Gln Arg Lys Tyr Lys Tyr Glu Pro Leu Gly Gln Gly Phe Leu         
                165                 170                 175             

cat gta gca ccg cct gat acg tat cga aat cca gag gat gtt cat aca      576
His Val Ala Pro Pro Asp Thr Tyr Arg Asn Pro Glu Asp Val His Thr         
            180                 185                 190                 

ctg gca agt gct gag gaa atc gat cgt gtc atg aca tgg gag tta agc      624
Leu Ala Ser Ala Glu Glu Ile Asp Arg Val Met Thr Trp Glu Leu Ser         
        195                 200                 205                     

caa aca gta gcc ggt gtg att atg gag cca atc att act ggg ggc gga      672
Gln Thr Val Ala Gly Val Ile Met Glu Pro Ile Ile Thr Gly Gly Gly         
    210                 215                 220                         

att tta atg cct cct gat gga tat atg gga aaa gta aaa gaa att tgc      720
Ile Leu Met Pro Pro Asp Gly Tyr Met Gly Lys Val Lys Glu Ile Cys         
225                 230                 235                 240         

gag aag cac ggt gcg ttg ctc att tgt gat gaa gtt ata tgt gga ttt      768
Glu Lys His Gly Ala Leu Leu Ile Cys Asp Glu Val Ile Cys Gly Phe         
                245                 250                 255             

ggc cgg aca ggg aag cca ttt gga ttt atg aat tat ggc gtc aaa cca      816
Gly Arg Thr Gly Lys Pro Phe Gly Phe Met Asn Tyr Gly Val Lys Pro         
            260                 265                 270                 

gat atc att aca atg gca aaa ggt att aca agt gcg tat ctt cct ttg      864
Asp Ile Ile Thr Met Ala Lys Gly Ile Thr Ser Ala Tyr Leu Pro Leu         
        275                 280                 285                     

tca gca aca gca gtt aga cga gag gtt tat gag gca ttc gta ggt agt      912
Ser Ala Thr Ala Val Arg Arg Glu Val Tyr Glu Ala Phe Val Gly Ser         
    290                 295                 300                         

gat gat tat gat cgc ttc cgc cat gta aat acg ttc gga ggg aat cct      960
Asp Asp Tyr Asp Arg Phe Arg His Val Asn Thr Phe Gly Gly Asn Pro         
305                 310                 315                 320         

gct gct tgc gct tta gct ttg aag aat tta gaa att atg gag aat gag     1008
Ala Ala Cys Ala Leu Ala Leu Lys Asn Leu Glu Ile Met Glu Asn Glu         
                325                 330                 335             

aaa ctc att gaa cgt tcc aaa gaa ttg ggt gaa cga ctg tta tat gag     1056
Lys Leu Ile Glu Arg Ser Lys Glu Leu Gly Glu Arg Leu Leu Tyr Glu         
            340                 345                 350                 

cta gag gat gta aaa gag cat cca aac gta ggg gat gtt cgc gga aag     1104
Leu Glu Asp Val Lys Glu His Pro Asn Val Gly Asp Val Arg Gly Lys         
        355                 360                 365                     

ggc ctt ctt tta ggc att gaa cta gtg gaa gat aag caa aca aaa gaa     1152
Gly Leu Leu Leu Gly Ile Glu Leu Val Glu Asp Lys Gln Thr Lys Glu         
    370                 375                 380                         

ccg gct tcc att gaa aag atg aac aaa gtc atc aat gct tgt aaa gaa     1200
Pro Ala Ser Ile Glu Lys Met Asn Lys Val Ile Asn Ala Cys Lys Glu         
385                 390                 395                 400         

aaa ggt cta att att ggt aaa aat ggt gac act gtc gca ggt tac aat     1248
Lys Gly Leu Ile Ile Gly Lys Asn Gly Asp Thr Val Ala Gly Tyr Asn         
                405                 410                 415             

aat att ttg cag ctt gca cct cca tta agc atc aca gag gaa gac ttt     1296
Asn Ile Leu Gln Leu Ala Pro Pro Leu Ser Ile Thr Glu Glu Asp Phe         
            420                 425                 430                 

act ttt atc gtt aaa aca atg aaa gaa tgt tta tcc cgc att aac ggg     1344
Thr Phe Ile Val Lys Thr Met Lys Glu Cys Leu Ser Arg Ile Asn Gly         
        435                 440                 445                     

cag taa                                                             1350
Gln                                                                     
                                                                        


<210>  83
<211>  449
<212>  PRT
<213>  Bacillus weihenstephanensis

<400>  83

Val Gln Ala Thr Glu Gln Thr Gln Ser Leu Lys Lys Thr Asp Glu Lys 
1               5                   10                  15      


Tyr Leu Trp His Ala Met Arg Gly Ala Ala Pro Ser Pro Thr Asn Leu 
            20                  25                  30          


Ile Ile Thr Lys Ala Glu Gly Ala Trp Val Thr Asp Ile Asp Gly Asn 
        35                  40                  45              


Arg Tyr Leu Asp Gly Met Ser Gly Leu Trp Cys Val Asn Val Gly Tyr 
    50                  55                  60                  


Gly Arg Lys Glu Leu Ala Arg Ala Ala Phe Glu Gln Leu Glu Glu Met 
65                  70                  75                  80  


Pro Tyr Phe Pro Leu Thr Gln Ser His Val Pro Ala Ile Lys Leu Ala 
                85                  90                  95      


Glu Lys Leu Asn Glu Trp Leu Asp Asp Glu Tyr Val Ile Phe Phe Ser 
            100                 105                 110         


Asn Ser Gly Ser Glu Ala Asn Glu Thr Ala Phe Lys Ile Ala Arg Gln 
        115                 120                 125             


Tyr His Gln Gln Lys Gly Asp His Gly Arg Tyr Lys Phe Ile Ser Arg 
    130                 135                 140                 


Tyr Arg Ala Tyr His Gly Asn Ser Met Gly Ala Leu Ala Ala Thr Gly 
145                 150                 155                 160 


Gln Ala Gln Arg Lys Tyr Lys Tyr Glu Pro Leu Gly Gln Gly Phe Leu 
                165                 170                 175     


His Val Ala Pro Pro Asp Thr Tyr Arg Asn Pro Glu Asp Val His Thr 
            180                 185                 190         


Leu Ala Ser Ala Glu Glu Ile Asp Arg Val Met Thr Trp Glu Leu Ser 
        195                 200                 205             


Gln Thr Val Ala Gly Val Ile Met Glu Pro Ile Ile Thr Gly Gly Gly 
    210                 215                 220                 


Ile Leu Met Pro Pro Asp Gly Tyr Met Gly Lys Val Lys Glu Ile Cys 
225                 230                 235                 240 


Glu Lys His Gly Ala Leu Leu Ile Cys Asp Glu Val Ile Cys Gly Phe 
                245                 250                 255     


Gly Arg Thr Gly Lys Pro Phe Gly Phe Met Asn Tyr Gly Val Lys Pro 
            260                 265                 270         


Asp Ile Ile Thr Met Ala Lys Gly Ile Thr Ser Ala Tyr Leu Pro Leu 
        275                 280                 285             


Ser Ala Thr Ala Val Arg Arg Glu Val Tyr Glu Ala Phe Val Gly Ser 
    290                 295                 300                 


Asp Asp Tyr Asp Arg Phe Arg His Val Asn Thr Phe Gly Gly Asn Pro 
305                 310                 315                 320 


Ala Ala Cys Ala Leu Ala Leu Lys Asn Leu Glu Ile Met Glu Asn Glu 
                325                 330                 335     


Lys Leu Ile Glu Arg Ser Lys Glu Leu Gly Glu Arg Leu Leu Tyr Glu 
            340                 345                 350         


Leu Glu Asp Val Lys Glu His Pro Asn Val Gly Asp Val Arg Gly Lys 
        355                 360                 365             


Gly Leu Leu Leu Gly Ile Glu Leu Val Glu Asp Lys Gln Thr Lys Glu 
    370                 375                 380                 


Pro Ala Ser Ile Glu Lys Met Asn Lys Val Ile Asn Ala Cys Lys Glu 
385                 390                 395                 400 


Lys Gly Leu Ile Ile Gly Lys Asn Gly Asp Thr Val Ala Gly Tyr Asn 
                405                 410                 415     


Asn Ile Leu Gln Leu Ala Pro Pro Leu Ser Ile Thr Glu Glu Asp Phe 
            420                 425                 430         


Thr Phe Ile Val Lys Thr Met Lys Glu Cys Leu Ser Arg Ile Asn Gly 
        435                 440                 445             


Gln 
    


<210>  84
<211>  1350
<212>  DNA
<213>  Artificial

<220>
<223>  B. weihenstephanensis KBAB4 aminotransferase codon-optimised gene

<400>  84
atgcaggcta ccgaacaaac ccaatctctg aaaaagactg acgaaaaata tctgtggcac     60

gcgatgcgcg gtgcagctcc gtctccgacc aacctgatta ttaccaaagc tgaaggcgcg    120

tgggtgaccg acattgacgg taaccgttat ctggatggca tgagcggcct gtggtgtgtt    180

aatgtcggtt atggccgtaa ggagctggcg cgcgcggcat ttgaacaact ggaagaaatg    240

ccgtacttcc cgctgactca aagccatgtg ccggctatca aactggcgga aaaactgaac    300

gaatggctgg acgacgaata cgtgattttc ttctctaatt ctggctccga agcaaacgaa    360

accgcattca aaatcgcccg tcaatatcac cagcagaaag gtgaccacgg ccgctataaa    420

ttcatcagcc gttatcgtgc ataccatggt aattctatgg gtgcgctggc tgctaccggt    480

caggctcagc gcaaatacaa gtacgaaccg ctgggtcagg gttttctgca cgttgcacca    540

ccggatacct accgtaaccc ggaagacgtc cacaccctgg cttctgccga agaaatcgat    600

cgtgttatga cctgggagct gtcccagact gttgcgggtg ttatcatgga acctattatt    660

accggtggtg gcattctgat gccgccggac ggttatatgg gtaaagtcaa ggaaatctgc    720

gaaaaacacg gcgcgctgct gatctgcgat gaagttatct gtggcttcgg tcgcaccggc    780

aaaccatttg gcttcatgaa ttatggcgta aaacctgaca ttattaccat ggctaaaggc    840

attacttccg cttatctgcc gctgagcgcg accgcagttc gccgcgaagt ttatgaagcg    900

tttgttggtt ctgatgatta cgaccgtttc cgtcatgtaa acacgtttgg cggtaaccca    960

gcggcatgtg cgctggcgct gaaaaacctg gaaatcatgg aaaacgaaaa gctgatcgaa   1020

cgtagcaaag aactgggtga acgtctgctg tacgaactgg aagatgtcaa agaacacccg   1080

aacgtgggcg atgttcgcgg taaaggcctg ctgctgggta ttgaactggt tgaagacaaa   1140

cagaccaagg aaccggcttc cattgaaaag atgaacaaag tgattaacgc gtgcaaagag   1200

aaaggcctga tcattggtaa gaacggtgat accgtggcag gttataacaa cattctgcag   1260

ctggcgccgc ctctgagcat cactgaagaa gatttcacct tcatcgtcaa aactatgaag   1320

gagtgcctga gccgcatcaa tggtcagtaa                                    1350


<210>  85
<211>  1371
<212>  DNA
<213>  Pseudomonas aeruginosa


<220>
<221>  CDS
<222>  (1)..(1371)

<400>  85
atg aac agc caa atc acc aac gcc aag acc cgt gag tgg cag gcg ttg       48
Met Asn Ser Gln Ile Thr Asn Ala Lys Thr Arg Glu Trp Gln Ala Leu         
1               5                   10                  15              

agc cgc gac cac cat ctg ccg ccg ttc acc gac tac aag cag ttg aac       96
Ser Arg Asp His His Leu Pro Pro Phe Thr Asp Tyr Lys Gln Leu Asn         
            20                  25                  30                  

gag aag ggc gcg cgg atc atc acc aag gcc gaa ggc gtc tat atc tgg      144
Glu Lys Gly Ala Arg Ile Ile Thr Lys Ala Glu Gly Val Tyr Ile Trp         
        35                  40                  45                      

gac agc gag ggc aac aag atc ctc gat gcg atg gcc ggc ctc tgg tgc      192
Asp Ser Glu Gly Asn Lys Ile Leu Asp Ala Met Ala Gly Leu Trp Cys         
    50                  55                  60                          

gtc aac gtc ggc tac ggc cgc gag gag ctg gtc cag gcc gcc acc cgg      240
Val Asn Val Gly Tyr Gly Arg Glu Glu Leu Val Gln Ala Ala Thr Arg         
65                  70                  75                  80          

cag atg cgc gag ttg ccg ttc tac aac ctg ttc ttc cag acc gcc cac      288
Gln Met Arg Glu Leu Pro Phe Tyr Asn Leu Phe Phe Gln Thr Ala His         
                85                  90                  95              

ccg ccg gtg gtc gag ctg gcc aag gcg atc gcc gac gtc gct ccg gaa      336
Pro Pro Val Val Glu Leu Ala Lys Ala Ile Ala Asp Val Ala Pro Glu         
            100                 105                 110                 

ggc atg aac cac gtg ttc ttc acc ggc tcc ggc tcc gag gcc aac gac      384
Gly Met Asn His Val Phe Phe Thr Gly Ser Gly Ser Glu Ala Asn Asp         
        115                 120                 125                     

acc gtg ctg cgt atg gtc cgc cac tat tgg gcg acc aag ggc cag ccg      432
Thr Val Leu Arg Met Val Arg His Tyr Trp Ala Thr Lys Gly Gln Pro         
    130                 135                 140                         

cag aag aaa gtg gtg atc ggc cgc tgg aac ggc tac cac ggc tcc acc      480
Gln Lys Lys Val Val Ile Gly Arg Trp Asn Gly Tyr His Gly Ser Thr         
145                 150                 155                 160         

gtc gcc ggc gtc agc ctg ggc ggc atg aag gcg ttg cat gag cag ggt      528
Val Ala Gly Val Ser Leu Gly Gly Met Lys Ala Leu His Glu Gln Gly         
                165                 170                 175             

gat ttc ccc atc ccg ggc atc gtc cac atc gcc cag ccc tac tgg tac      576
Asp Phe Pro Ile Pro Gly Ile Val His Ile Ala Gln Pro Tyr Trp Tyr         
            180                 185                 190                 

ggc gag ggc ggc gac atg tcg ccg gac gag ttc ggc gtc tgg gcc gcc      624
Gly Glu Gly Gly Asp Met Ser Pro Asp Glu Phe Gly Val Trp Ala Ala         
        195                 200                 205                     

gag cag ttg gag aag aag att ctc gaa gtg ggc gag gaa aac gtc gcc      672
Glu Gln Leu Glu Lys Lys Ile Leu Glu Val Gly Glu Glu Asn Val Ala         
    210                 215                 220                         

gcc ttc atc gcc gag ccg atc cag ggc gcc ggc ggc gtg atc gtc ccg      720
Ala Phe Ile Ala Glu Pro Ile Gln Gly Ala Gly Gly Val Ile Val Pro         
225                 230                 235                 240         

ccg gac acc tac tgg ccg aag atc cgc gag atc ctc gcc aag tac gac      768
Pro Asp Thr Tyr Trp Pro Lys Ile Arg Glu Ile Leu Ala Lys Tyr Asp         
                245                 250                 255             

atc ctg ttc atc gcc gac gaa gtg atc tgc ggc ttc ggc cgt acc ggc      816
Ile Leu Phe Ile Ala Asp Glu Val Ile Cys Gly Phe Gly Arg Thr Gly         
            260                 265                 270                 

gag tgg ttc ggc agc cag tac tac ggc aac gcc ccg gac ctg atg ccg      864
Glu Trp Phe Gly Ser Gln Tyr Tyr Gly Asn Ala Pro Asp Leu Met Pro         
        275                 280                 285                     

atc gcc aag ggc ctc acc tcc ggc tac atc ccc atg ggc ggg gtg gtg      912
Ile Ala Lys Gly Leu Thr Ser Gly Tyr Ile Pro Met Gly Gly Val Val         
    290                 295                 300                         

gtg cgc gac gag atc gtc gaa gtg ctc aac cag ggc ggc gag ttc tac      960
Val Arg Asp Glu Ile Val Glu Val Leu Asn Gln Gly Gly Glu Phe Tyr         
305                 310                 315                 320         

cac ggc ttc acc tat tcc ggt cac ccg gtg gcg gcc gcc gtg gcc ctg     1008
His Gly Phe Thr Tyr Ser Gly His Pro Val Ala Ala Ala Val Ala Leu         
                325                 330                 335             

gag aac atc cgc atc ctg cgc gaa gag aag atc atc gag aag gtg aag     1056
Glu Asn Ile Arg Ile Leu Arg Glu Glu Lys Ile Ile Glu Lys Val Lys         
            340                 345                 350                 

gcg gaa acg gca ccg tat ttg cag aaa cgc tgg cag gag ctg gcc gac     1104
Ala Glu Thr Ala Pro Tyr Leu Gln Lys Arg Trp Gln Glu Leu Ala Asp         
        355                 360                 365                     

cac ccg ttg gtg ggc gaa gcg cgc ggg gtc ggc atg gtc gcc gcc ctg     1152
His Pro Leu Val Gly Glu Ala Arg Gly Val Gly Met Val Ala Ala Leu         
    370                 375                 380                         

gag ctg gtc aag aac aag aag acc cgc gag cgt ttc acc gac aag ggc     1200
Glu Leu Val Lys Asn Lys Lys Thr Arg Glu Arg Phe Thr Asp Lys Gly         
385                 390                 395                 400         

gtc ggg atg ctg tgc cgg gaa cat tgt ttc cgc aac ggt ttg atc atg     1248
Val Gly Met Leu Cys Arg Glu His Cys Phe Arg Asn Gly Leu Ile Met         
                405                 410                 415             

cgc gcg gtg ggc gac act atg att atc tcg ccg ccg ctg gtg atc gat     1296
Arg Ala Val Gly Asp Thr Met Ile Ile Ser Pro Pro Leu Val Ile Asp         
            420                 425                 430                 

ccg tcg cag atc gat gag ttg atc acc ctg gcg cgc aag tgc ctc gat     1344
Pro Ser Gln Ile Asp Glu Leu Ile Thr Leu Ala Arg Lys Cys Leu Asp         
        435                 440                 445                     

cag acc gcc gcc gcc gtc ctg gct tga                                 1371
Gln Thr Ala Ala Ala Val Leu Ala                                         
    450                 455                                             


<210>  86
<211>  456
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  86

Met Asn Ser Gln Ile Thr Asn Ala Lys Thr Arg Glu Trp Gln Ala Leu 
1               5                   10                  15      


Ser Arg Asp His His Leu Pro Pro Phe Thr Asp Tyr Lys Gln Leu Asn 
            20                  25                  30          


Glu Lys Gly Ala Arg Ile Ile Thr Lys Ala Glu Gly Val Tyr Ile Trp 
        35                  40                  45              


Asp Ser Glu Gly Asn Lys Ile Leu Asp Ala Met Ala Gly Leu Trp Cys 
    50                  55                  60                  


Val Asn Val Gly Tyr Gly Arg Glu Glu Leu Val Gln Ala Ala Thr Arg 
65                  70                  75                  80  


Gln Met Arg Glu Leu Pro Phe Tyr Asn Leu Phe Phe Gln Thr Ala His 
                85                  90                  95      


Pro Pro Val Val Glu Leu Ala Lys Ala Ile Ala Asp Val Ala Pro Glu 
            100                 105                 110         


Gly Met Asn His Val Phe Phe Thr Gly Ser Gly Ser Glu Ala Asn Asp 
        115                 120                 125             


Thr Val Leu Arg Met Val Arg His Tyr Trp Ala Thr Lys Gly Gln Pro 
    130                 135                 140                 


Gln Lys Lys Val Val Ile Gly Arg Trp Asn Gly Tyr His Gly Ser Thr 
145                 150                 155                 160 


Val Ala Gly Val Ser Leu Gly Gly Met Lys Ala Leu His Glu Gln Gly 
                165                 170                 175     


Asp Phe Pro Ile Pro Gly Ile Val His Ile Ala Gln Pro Tyr Trp Tyr 
            180                 185                 190         


Gly Glu Gly Gly Asp Met Ser Pro Asp Glu Phe Gly Val Trp Ala Ala 
        195                 200                 205             


Glu Gln Leu Glu Lys Lys Ile Leu Glu Val Gly Glu Glu Asn Val Ala 
    210                 215                 220                 


Ala Phe Ile Ala Glu Pro Ile Gln Gly Ala Gly Gly Val Ile Val Pro 
225                 230                 235                 240 


Pro Asp Thr Tyr Trp Pro Lys Ile Arg Glu Ile Leu Ala Lys Tyr Asp 
                245                 250                 255     


Ile Leu Phe Ile Ala Asp Glu Val Ile Cys Gly Phe Gly Arg Thr Gly 
            260                 265                 270         


Glu Trp Phe Gly Ser Gln Tyr Tyr Gly Asn Ala Pro Asp Leu Met Pro 
        275                 280                 285             


Ile Ala Lys Gly Leu Thr Ser Gly Tyr Ile Pro Met Gly Gly Val Val 
    290                 295                 300                 


Val Arg Asp Glu Ile Val Glu Val Leu Asn Gln Gly Gly Glu Phe Tyr 
305                 310                 315                 320 


His Gly Phe Thr Tyr Ser Gly His Pro Val Ala Ala Ala Val Ala Leu 
                325                 330                 335     


Glu Asn Ile Arg Ile Leu Arg Glu Glu Lys Ile Ile Glu Lys Val Lys 
            340                 345                 350         


Ala Glu Thr Ala Pro Tyr Leu Gln Lys Arg Trp Gln Glu Leu Ala Asp 
        355                 360                 365             


His Pro Leu Val Gly Glu Ala Arg Gly Val Gly Met Val Ala Ala Leu 
    370                 375                 380                 


Glu Leu Val Lys Asn Lys Lys Thr Arg Glu Arg Phe Thr Asp Lys Gly 
385                 390                 395                 400 


Val Gly Met Leu Cys Arg Glu His Cys Phe Arg Asn Gly Leu Ile Met 
                405                 410                 415     


Arg Ala Val Gly Asp Thr Met Ile Ile Ser Pro Pro Leu Val Ile Asp 
            420                 425                 430         


Pro Ser Gln Ile Asp Glu Leu Ile Thr Leu Ala Arg Lys Cys Leu Asp 
        435                 440                 445             


Gln Thr Ala Ala Ala Val Leu Ala 
    450                 455     


<210>  87
<211>  70
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  87
ggggacaagt ttgtacaaaa aagcaggcta ggaggaatta accatgaaca gccaaatcac     60

caacgccaag                                                            70


<210>  88
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  primer

<400>  88
ggggaccact ttgtacaaga aagctgggtt caagccagga cggcggcgg                 49


<210>  89
<211>  849
<212>  DNA
<213>  Bacillus subtilis


<220>
<221>  CDS
<222>  (1)..(843)

<400>  89
atg aag gtt tta gtc aat ggc cgg ctg att ggg cgc agt gaa gca tca       48
Met Lys Val Leu Val Asn Gly Arg Leu Ile Gly Arg Ser Glu Ala Ser         
1               5                   10                  15              

atc gat ttg gaa gat cgc ggt tat cag ttt ggt gac ggc atc tat gaa       96
Ile Asp Leu Glu Asp Arg Gly Tyr Gln Phe Gly Asp Gly Ile Tyr Glu         
            20                  25                  30                  

gtg atc agg gtg tac aaa gga gta ttg ttc ggc tta cgt gag cat gca      144
Val Ile Arg Val Tyr Lys Gly Val Leu Phe Gly Leu Arg Glu His Ala         
        35                  40                  45                      

gag cgt ttt ttc aga agt gct gct gaa atc gga att tca ctg cca ttc      192
Glu Arg Phe Phe Arg Ser Ala Ala Glu Ile Gly Ile Ser Leu Pro Phe         
    50                  55                  60                          

agt ata gaa gat ctc gag tgg gac ctg caa aag ctt gta cag gaa aat      240
Ser Ile Glu Asp Leu Glu Trp Asp Leu Gln Lys Leu Val Gln Glu Asn         
65                  70                  75                  80          

gcg gtc agt gag gga gcg gta tac att cag aca aca aga ggt gtg gcc      288
Ala Val Ser Glu Gly Ala Val Tyr Ile Gln Thr Thr Arg Gly Val Ala         
                85                  90                  95              

ccg cga aaa cac cag tat gaa gcc ggc ctc gag ccg cag act act gcc      336
Pro Arg Lys His Gln Tyr Glu Ala Gly Leu Glu Pro Gln Thr Thr Ala         
            100                 105                 110                 

tat acg ttt acg gtg aaa aaa ccg gag caa gag cag gca tac gga gtg      384
Tyr Thr Phe Thr Val Lys Lys Pro Glu Gln Glu Gln Ala Tyr Gly Val         
        115                 120                 125                     

gcg gcc att aca gat gag gat ctt cgc tgg tta aga tgt gat atc aaa      432
Ala Ala Ile Thr Asp Glu Asp Leu Arg Trp Leu Arg Cys Asp Ile Lys         
    130                 135                 140                         

agt ctg aat tta ctg tat aat gtc atg acg aag caa agg gcc tat gaa      480
Ser Leu Asn Leu Leu Tyr Asn Val Met Thr Lys Gln Arg Ala Tyr Glu         
145                 150                 155                 160         

gcc gga gca ttt gaa gcc att tta ctt agg gac ggc gtt gtt acg gag      528
Ala Gly Ala Phe Glu Ala Ile Leu Leu Arg Asp Gly Val Val Thr Glu         
                165                 170                 175             

ggt aca tcc tct aac gtt tat gcc gtt atc aac ggc aca gtg cga aca      576
Gly Thr Ser Ser Asn Val Tyr Ala Val Ile Asn Gly Thr Val Arg Thr         
            180                 185                 190                 

cat ccg gct aat cgg ctc att ctc aat gga att aca cgg atg aat att      624
His Pro Ala Asn Arg Leu Ile Leu Asn Gly Ile Thr Arg Met Asn Ile         
        195                 200                 205                     

tta gga ctg att gag aag aat ggg atc aaa ctg gat gag act cct gtc      672
Leu Gly Leu Ile Glu Lys Asn Gly Ile Lys Leu Asp Glu Thr Pro Val         
    210                 215                 220                         

agt gaa gaa gag ttg aaa cag gcg gaa gag atc ttt att tcg tca acg      720
Ser Glu Glu Glu Leu Lys Gln Ala Glu Glu Ile Phe Ile Ser Ser Thr         
225                 230                 235                 240         

acg gca gaa att att ccg gtc gtg acg ctc gat gga caa tcg atc gga      768
Thr Ala Glu Ile Ile Pro Val Val Thr Leu Asp Gly Gln Ser Ile Gly         
                245                 250                 255             

agc ggg aaa ccc gga ccg gtg acc aaa cag ctt cag gct gct ttt caa      816
Ser Gly Lys Pro Gly Pro Val Thr Lys Gln Leu Gln Ala Ala Phe Gln         
            260                 265                 270                 

gaa agc att caa cag gct gct agc att tcataa                           849
Glu Ser Ile Gln Gln Ala Ala Ser Ile                                     
        275                 280                                         


<210>  90
<211>  281
<212>  PRT
<213>  Bacillus subtilis

<400>  90

Met Lys Val Leu Val Asn Gly Arg Leu Ile Gly Arg Ser Glu Ala Ser 
1               5                   10                  15      


Ile Asp Leu Glu Asp Arg Gly Tyr Gln Phe Gly Asp Gly Ile Tyr Glu 
            20                  25                  30          


Val Ile Arg Val Tyr Lys Gly Val Leu Phe Gly Leu Arg Glu His Ala 
        35                  40                  45              


Glu Arg Phe Phe Arg Ser Ala Ala Glu Ile Gly Ile Ser Leu Pro Phe 
    50                  55                  60                  


Ser Ile Glu Asp Leu Glu Trp Asp Leu Gln Lys Leu Val Gln Glu Asn 
65                  70                  75                  80  


Ala Val Ser Glu Gly Ala Val Tyr Ile Gln Thr Thr Arg Gly Val Ala 
                85                  90                  95      


Pro Arg Lys His Gln Tyr Glu Ala Gly Leu Glu Pro Gln Thr Thr Ala 
            100                 105                 110         


Tyr Thr Phe Thr Val Lys Lys Pro Glu Gln Glu Gln Ala Tyr Gly Val 
        115                 120                 125             


Ala Ala Ile Thr Asp Glu Asp Leu Arg Trp Leu Arg Cys Asp Ile Lys 
    130                 135                 140                 


Ser Leu Asn Leu Leu Tyr Asn Val Met Thr Lys Gln Arg Ala Tyr Glu 
145                 150                 155                 160 


Ala Gly Ala Phe Glu Ala Ile Leu Leu Arg Asp Gly Val Val Thr Glu 
                165                 170                 175     


Gly Thr Ser Ser Asn Val Tyr Ala Val Ile Asn Gly Thr Val Arg Thr 
            180                 185                 190         


His Pro Ala Asn Arg Leu Ile Leu Asn Gly Ile Thr Arg Met Asn Ile 
        195                 200                 205             


Leu Gly Leu Ile Glu Lys Asn Gly Ile Lys Leu Asp Glu Thr Pro Val 
    210                 215                 220                 


Ser Glu Glu Glu Leu Lys Gln Ala Glu Glu Ile Phe Ile Ser Ser Thr 
225                 230                 235                 240 


Thr Ala Glu Ile Ile Pro Val Val Thr Leu Asp Gly Gln Ser Ile Gly 
                245                 250                 255     


Ser Gly Lys Pro Gly Pro Val Thr Lys Gln Leu Gln Ala Ala Phe Gln 
            260                 265                 270         


Glu Ser Ile Gln Gln Ala Ala Ser Ile 
        275                 280     


<210>  91
<211>  1347
<212>  DNA
<213>  Bacillus subtilis


<220>
<221>  CDS
<222>  (1)..(1347)

<400>  91
atg act cat gat ttg ata gaa aaa agt aaa aag cac ctc tgg ctg cca       48
Met Thr His Asp Leu Ile Glu Lys Ser Lys Lys His Leu Trp Leu Pro         
1               5                   10                  15              

ttt acc caa atg aaa gat tat gat gaa aac ccc tta atc atc gaa agc       96
Phe Thr Gln Met Lys Asp Tyr Asp Glu Asn Pro Leu Ile Ile Glu Ser         
            20                  25                  30                  

ggg act gga atc aaa gtc aaa gac ata aac ggc aag gaa tac tat gac      144
Gly Thr Gly Ile Lys Val Lys Asp Ile Asn Gly Lys Glu Tyr Tyr Asp         
        35                  40                  45                      

ggt ttt tca tcg gtt tgg ctt aat gtc cac gga cac cgc aaa aaa gaa      192
Gly Phe Ser Ser Val Trp Leu Asn Val His Gly His Arg Lys Lys Glu         
    50                  55                  60                          

cta gat gac gcc ata aaa aaa cag ctc gga aaa att gcg cac tcc acg      240
Leu Asp Asp Ala Ile Lys Lys Gln Leu Gly Lys Ile Ala His Ser Thr         
65                  70                  75                  80          

tta ttg ggc atg acc aat gtt cca gca acc cag ctt gcc gaa aca tta      288
Leu Leu Gly Met Thr Asn Val Pro Ala Thr Gln Leu Ala Glu Thr Leu         
                85                  90                  95              

atc gac atc agc cca aaa aag ctc acg cgg gtc ttt tat tca gac agc      336
Ile Asp Ile Ser Pro Lys Lys Leu Thr Arg Val Phe Tyr Ser Asp Ser         
            100                 105                 110                 

ggc gca gag gcg atg gaa ata gcc cta aaa atg gcg ttt cag tat tgg      384
Gly Ala Glu Ala Met Glu Ile Ala Leu Lys Met Ala Phe Gln Tyr Trp         
        115                 120                 125                     

aag aac atc ggg aag ccc gag aaa caa aaa ttc atc gca atg aaa aac      432
Lys Asn Ile Gly Lys Pro Glu Lys Gln Lys Phe Ile Ala Met Lys Asn         
    130                 135                 140                         

ggg tat cac ggt gat acg att ggc gcc gtc agt gtc ggt tca att gag      480
Gly Tyr His Gly Asp Thr Ile Gly Ala Val Ser Val Gly Ser Ile Glu         
145                 150                 155                 160         

ctt ttt cac cac gta tac ggc ccg ttg atg ttc gag agt tac aag gcc      528
Leu Phe His His Val Tyr Gly Pro Leu Met Phe Glu Ser Tyr Lys Ala         
                165                 170                 175             

ccg att cct tat gtg tat cgt tct gaa agc ggt gat cct gat gag tgc      576
Pro Ile Pro Tyr Val Tyr Arg Ser Glu Ser Gly Asp Pro Asp Glu Cys         
            180                 185                 190                 

cgt gat cag tgc ctc cga gag ctt gca cag ctg ctt gag gaa cat cat      624
Arg Asp Gln Cys Leu Arg Glu Leu Ala Gln Leu Leu Glu Glu His His         
        195                 200                 205                     

gag gaa att gcc gcg ctt tcc att gaa tca atg gta caa ggc gcg tcc      672
Glu Glu Ile Ala Ala Leu Ser Ile Glu Ser Met Val Gln Gly Ala Ser         
    210                 215                 220                         

ggt atg atc gtg atg ccg gaa gga tat ttg gca ggc gtg cgc gag cta      720
Gly Met Ile Val Met Pro Glu Gly Tyr Leu Ala Gly Val Arg Glu Leu         
225                 230                 235                 240         

tgt aca aca tac gat gtc tta atg atc gtt gat gaa gtc gct aca ggc      768
Cys Thr Thr Tyr Asp Val Leu Met Ile Val Asp Glu Val Ala Thr Gly         
                245                 250                 255             

ttt ggc cgt aca gga aaa atg ttt gcg tgc gag cac gag aat gtc cag      816
Phe Gly Arg Thr Gly Lys Met Phe Ala Cys Glu His Glu Asn Val Gln         
            260                 265                 270                 

cct gat ctg atg gct gcc ggt aaa ggc att aca gga ggc tat ttg cca      864
Pro Asp Leu Met Ala Ala Gly Lys Gly Ile Thr Gly Gly Tyr Leu Pro         
        275                 280                 285                     

att gcc gtt acg ttt gcc act gaa gac atc tat aag gca ttc tat gat      912
Ile Ala Val Thr Phe Ala Thr Glu Asp Ile Tyr Lys Ala Phe Tyr Asp         
    290                 295                 300                         

gat tat gaa aac cta aaa acc ttt ttc cat ggc cat tcc tat aca ggc      960
Asp Tyr Glu Asn Leu Lys Thr Phe Phe His Gly His Ser Tyr Thr Gly         
305                 310                 315                 320         

aat cag ctt ggc tgt gcg gtt gcg ctt gaa aat ctg gca tta ttt gaa     1008
Asn Gln Leu Gly Cys Ala Val Ala Leu Glu Asn Leu Ala Leu Phe Glu         
                325                 330                 335             

tct gaa aac att gtg gaa caa gta gcg gaa aaa agt aaa aag ctc cat     1056
Ser Glu Asn Ile Val Glu Gln Val Ala Glu Lys Ser Lys Lys Leu His         
            340                 345                 350                 

ttt ctt ctt caa gat ctg cac gct ctt cct cat gtt ggg gat att cgg     1104
Phe Leu Leu Gln Asp Leu His Ala Leu Pro His Val Gly Asp Ile Arg         
        355                 360                 365                     

cag ctt ggc ttt atg tgc ggt gca gag ctt gta cga tca aag gaa act     1152
Gln Leu Gly Phe Met Cys Gly Ala Glu Leu Val Arg Ser Lys Glu Thr         
    370                 375                 380                         

aaa gaa cct tac ccg gct gat cgg cgg att gga tac aaa gtt tcc tta     1200
Lys Glu Pro Tyr Pro Ala Asp Arg Arg Ile Gly Tyr Lys Val Ser Leu         
385                 390                 395                 400         

aaa atg aga gag tta gga atg ctg aca aga ccg ctt ggg gac gtg att     1248
Lys Met Arg Glu Leu Gly Met Leu Thr Arg Pro Leu Gly Asp Val Ile         
                405                 410                 415             

gca ttt ctt cct cct ctt gcc agc aca gct gaa gag ctc tcg gaa atg     1296
Ala Phe Leu Pro Pro Leu Ala Ser Thr Ala Glu Glu Leu Ser Glu Met         
            420                 425                 430                 

gtt gcc att atg aaa caa gcg atc cac gag gtt acg agc ctt gaa gat     1344
Val Ala Ile Met Lys Gln Ala Ile His Glu Val Thr Ser Leu Glu Asp         
        435                 440                 445                     

tga                                                                 1347


<210>  92
<211>  448
<212>  PRT
<213>  Bacillus subtilis

<400>  92

Met Thr His Asp Leu Ile Glu Lys Ser Lys Lys His Leu Trp Leu Pro 
1               5                   10                  15      


Phe Thr Gln Met Lys Asp Tyr Asp Glu Asn Pro Leu Ile Ile Glu Ser 
            20                  25                  30          


Gly Thr Gly Ile Lys Val Lys Asp Ile Asn Gly Lys Glu Tyr Tyr Asp 
        35                  40                  45              


Gly Phe Ser Ser Val Trp Leu Asn Val His Gly His Arg Lys Lys Glu 
    50                  55                  60                  


Leu Asp Asp Ala Ile Lys Lys Gln Leu Gly Lys Ile Ala His Ser Thr 
65                  70                  75                  80  


Leu Leu Gly Met Thr Asn Val Pro Ala Thr Gln Leu Ala Glu Thr Leu 
                85                  90                  95      


Ile Asp Ile Ser Pro Lys Lys Leu Thr Arg Val Phe Tyr Ser Asp Ser 
            100                 105                 110         


Gly Ala Glu Ala Met Glu Ile Ala Leu Lys Met Ala Phe Gln Tyr Trp 
        115                 120                 125             


Lys Asn Ile Gly Lys Pro Glu Lys Gln Lys Phe Ile Ala Met Lys Asn 
    130                 135                 140                 


Gly Tyr His Gly Asp Thr Ile Gly Ala Val Ser Val Gly Ser Ile Glu 
145                 150                 155                 160 


Leu Phe His His Val Tyr Gly Pro Leu Met Phe Glu Ser Tyr Lys Ala 
                165                 170                 175     


Pro Ile Pro Tyr Val Tyr Arg Ser Glu Ser Gly Asp Pro Asp Glu Cys 
            180                 185                 190         


Arg Asp Gln Cys Leu Arg Glu Leu Ala Gln Leu Leu Glu Glu His His 
        195                 200                 205             


Glu Glu Ile Ala Ala Leu Ser Ile Glu Ser Met Val Gln Gly Ala Ser 
    210                 215                 220                 


Gly Met Ile Val Met Pro Glu Gly Tyr Leu Ala Gly Val Arg Glu Leu 
225                 230                 235                 240 


Cys Thr Thr Tyr Asp Val Leu Met Ile Val Asp Glu Val Ala Thr Gly 
                245                 250                 255     


Phe Gly Arg Thr Gly Lys Met Phe Ala Cys Glu His Glu Asn Val Gln 
            260                 265                 270         


Pro Asp Leu Met Ala Ala Gly Lys Gly Ile Thr Gly Gly Tyr Leu Pro 
        275                 280                 285             


Ile Ala Val Thr Phe Ala Thr Glu Asp Ile Tyr Lys Ala Phe Tyr Asp 
    290                 295                 300                 


Asp Tyr Glu Asn Leu Lys Thr Phe Phe His Gly His Ser Tyr Thr Gly 
305                 310                 315                 320 


Asn Gln Leu Gly Cys Ala Val Ala Leu Glu Asn Leu Ala Leu Phe Glu 
                325                 330                 335     


Ser Glu Asn Ile Val Glu Gln Val Ala Glu Lys Ser Lys Lys Leu His 
            340                 345                 350         


Phe Leu Leu Gln Asp Leu His Ala Leu Pro His Val Gly Asp Ile Arg 
        355                 360                 365             


Gln Leu Gly Phe Met Cys Gly Ala Glu Leu Val Arg Ser Lys Glu Thr 
    370                 375                 380                 


Lys Glu Pro Tyr Pro Ala Asp Arg Arg Ile Gly Tyr Lys Val Ser Leu 
385                 390                 395                 400 


Lys Met Arg Glu Leu Gly Met Leu Thr Arg Pro Leu Gly Asp Val Ile 
                405                 410                 415     


Ala Phe Leu Pro Pro Leu Ala Ser Thr Ala Glu Glu Leu Ser Glu Met 
            420                 425                 430         


Val Ala Ile Met Lys Gln Ala Ile His Glu Val Thr Ser Leu Glu Asp 
        435                 440                 445             


<210>  93
<211>  1467
<212>  DNA
<213>  Rhodobacter sphaeroides


<220>
<221>  CDS
<222>  (1)..(1467)

<400>  93
atg ccc ggt tgc ggg ggc ttg ccc ggg aat gaa ccg aaa tgc gga cga       48
Met Pro Gly Cys Gly Gly Leu Pro Gly Asn Glu Pro Lys Cys Gly Arg         
1               5                   10                  15              

gag ggg agg tcg gcg atg acg cgg aat gac gcg acg aat gct gcc gga       96
Glu Gly Arg Ser Ala Met Thr Arg Asn Asp Ala Thr Asn Ala Ala Gly         
            20                  25                  30                  

gcg gtg ggc gcg gcg atg cgg gat cac atc ctc ttg cct gca cag gaa      144
Ala Val Gly Ala Ala Met Arg Asp His Ile Leu Leu Pro Ala Gln Glu         
        35                  40                  45                      

atg gcg aag ctc ggc aag tcc gcg cag ccg gtg ctg act cat gcc gag      192
Met Ala Lys Leu Gly Lys Ser Ala Gln Pro Val Leu Thr His Ala Glu         
    50                  55                  60                          

ggc atc tat gtc cat acc gag gac ggc cgc cgc ctg atc gac ggg ccg      240
Gly Ile Tyr Val His Thr Glu Asp Gly Arg Arg Leu Ile Asp Gly Pro         
65                  70                  75                  80          

gcg ggc atg tgg tgc gcg cag gtg ggc tac ggc cgc cgc gag atc gtc      288
Ala Gly Met Trp Cys Ala Gln Val Gly Tyr Gly Arg Arg Glu Ile Val         
                85                  90                  95              

gat gcc atg gcg cat cag gcg atg gtg ctg ccc tat gcc tcg ccc tgg      336
Asp Ala Met Ala His Gln Ala Met Val Leu Pro Tyr Ala Ser Pro Trp         
            100                 105                 110                 

tat atg gcc acg agc ccc gcg gcg cgg ctg gcg gag aag atc gcc acg      384
Tyr Met Ala Thr Ser Pro Ala Ala Arg Leu Ala Glu Lys Ile Ala Thr         
        115                 120                 125                     

ctg acg ccg ggc gat ctc aac cgg atc ttt ttc acc acg ggc ggg tcg      432
Leu Thr Pro Gly Asp Leu Asn Arg Ile Phe Phe Thr Thr Gly Gly Ser         
    130                 135                 140                         

acc gcg gtg gac agc gcg ctg cgc ttc tcg gaa ttc tac aac aac gtg      480
Thr Ala Val Asp Ser Ala Leu Arg Phe Ser Glu Phe Tyr Asn Asn Val         
145                 150                 155                 160         

ctg ggc cgg ccg cag aag aag cgc atc atc gtg cgc tac gac ggc tat      528
Leu Gly Arg Pro Gln Lys Lys Arg Ile Ile Val Arg Tyr Asp Gly Tyr         
                165                 170                 175             

cac ggc tcg acg gcg ctc acc gcc gcc tgc acc ggc cgc acc ggc aac      576
His Gly Ser Thr Ala Leu Thr Ala Ala Cys Thr Gly Arg Thr Gly Asn         
            180                 185                 190                 

tgg ccg aac ttc gac atc gcg cag gac cgg atc tcg ttc ctc tcg agc      624
Trp Pro Asn Phe Asp Ile Ala Gln Asp Arg Ile Ser Phe Leu Ser Ser         
        195                 200                 205                     

ccc aat ccg cgc cac gcc ggc aac cgc agc cag gag gcg ttc ctc gac      672
Pro Asn Pro Arg His Ala Gly Asn Arg Ser Gln Glu Ala Phe Leu Asp         
    210                 215                 220                         

gat ctg gtg cag gaa ttc gag gac cgg atc gag agc ctc ggc ccc gac      720
Asp Leu Val Gln Glu Phe Glu Asp Arg Ile Glu Ser Leu Gly Pro Asp         
225                 230                 235                 240         

acg atc gcg gcc ttc ctg gcc gag ccg atc ctc gcc tcg ggc ggc gtc      768
Thr Ile Ala Ala Phe Leu Ala Glu Pro Ile Leu Ala Ser Gly Gly Val         
                245                 250                 255             

att att ccg ccc gca ggc tat cat gcg cgc ttc aag gcg atc tgc gag      816
Ile Ile Pro Pro Ala Gly Tyr His Ala Arg Phe Lys Ala Ile Cys Glu         
            260                 265                 270                 

aag cac gac atc ctc tat atc tcg gac gag gtg gtg acg ggc ttc ggc      864
Lys His Asp Ile Leu Tyr Ile Ser Asp Glu Val Val Thr Gly Phe Gly         
        275                 280                 285                     

cgt tgc ggc gag tgg ttc gcc tcg gag aag gtg ttc ggg gtg gtg ccg      912
Arg Cys Gly Glu Trp Phe Ala Ser Glu Lys Val Phe Gly Val Val Pro         
    290                 295                 300                         

gac atc atc acc ttc gcc aag ggc gtg acc tcg ggc tat gtg ccg ctc      960
Asp Ile Ile Thr Phe Ala Lys Gly Val Thr Ser Gly Tyr Val Pro Leu         
305                 310                 315                 320         

ggc ggc ctt gcg atc tcc gag gcg gtg ctg gcg cgg atc tcg ggc gag     1008
Gly Gly Leu Ala Ile Ser Glu Ala Val Leu Ala Arg Ile Ser Gly Glu         
                325                 330                 335             

aat gcc aag gga agc tgg ttc acc aac ggc tat acc tac agc aat cag     1056
Asn Ala Lys Gly Ser Trp Phe Thr Asn Gly Tyr Thr Tyr Ser Asn Gln         
            340                 345                 350                 

ccg gtg gcc tgc gcc gcg gcg ctt gcc aac atc gag ctg atg gag cgc     1104
Pro Val Ala Cys Ala Ala Ala Leu Ala Asn Ile Glu Leu Met Glu Arg         
        355                 360                 365                     

gag ggc atc gtc gat cag gcg cgc gag atg gcg gac tat ttc gcc gcg     1152
Glu Gly Ile Val Asp Gln Ala Arg Glu Met Ala Asp Tyr Phe Ala Ala         
    370                 375                 380                         

gcg ctg gct tcg ctg cgc gat ctg ccg ggc gtg gcg gaa acc cgg tcg     1200
Ala Leu Ala Ser Leu Arg Asp Leu Pro Gly Val Ala Glu Thr Arg Ser         
385                 390                 395                 400         

gtg ggc ctc gtg ggt tgc gtg caa tgc ctg ctc gac ccg acc cgg gcg     1248
Val Gly Leu Val Gly Cys Val Gln Cys Leu Leu Asp Pro Thr Arg Ala         
                405                 410                 415             

gac ggc acg gcc gag gac aag gcc ttc acc ctg aag atc gac gag cgc     1296
Asp Gly Thr Ala Glu Asp Lys Ala Phe Thr Leu Lys Ile Asp Glu Arg         
            420                 425                 430                 

tgc ttc gag ctc ggg ctg atc gtg cgc ccg ctg ggc gat ctc tgc gtg     1344
Cys Phe Glu Leu Gly Leu Ile Val Arg Pro Leu Gly Asp Leu Cys Val         
        435                 440                 445                     

atc tcg ccg ccg ctc atc atc tcg cgc gcg cag atc gac gag atg gtc     1392
Ile Ser Pro Pro Leu Ile Ile Ser Arg Ala Gln Ile Asp Glu Met Val         
    450                 455                 460                         

gcg atc atg cgg cag gcc atc acc gaa gtg agc gcc gcc cac ggt ctg     1440
Ala Ile Met Arg Gln Ala Ile Thr Glu Val Ser Ala Ala His Gly Leu         
465                 470                 475                 480         

acc gcg aaa gaa ccg gcc gcc gtc tga                                 1467
Thr Ala Lys Glu Pro Ala Ala Val                                         
                485                                                     


<210>  94
<211>  488
<212>  PRT
<213>  Rhodobacter sphaeroides

<400>  94

Met Pro Gly Cys Gly Gly Leu Pro Gly Asn Glu Pro Lys Cys Gly Arg 
1               5                   10                  15      


Glu Gly Arg Ser Ala Met Thr Arg Asn Asp Ala Thr Asn Ala Ala Gly 
            20                  25                  30          


Ala Val Gly Ala Ala Met Arg Asp His Ile Leu Leu Pro Ala Gln Glu 
        35                  40                  45              


Met Ala Lys Leu Gly Lys Ser Ala Gln Pro Val Leu Thr His Ala Glu 
    50                  55                  60                  


Gly Ile Tyr Val His Thr Glu Asp Gly Arg Arg Leu Ile Asp Gly Pro 
65                  70                  75                  80  


Ala Gly Met Trp Cys Ala Gln Val Gly Tyr Gly Arg Arg Glu Ile Val 
                85                  90                  95      


Asp Ala Met Ala His Gln Ala Met Val Leu Pro Tyr Ala Ser Pro Trp 
            100                 105                 110         


Tyr Met Ala Thr Ser Pro Ala Ala Arg Leu Ala Glu Lys Ile Ala Thr 
        115                 120                 125             


Leu Thr Pro Gly Asp Leu Asn Arg Ile Phe Phe Thr Thr Gly Gly Ser 
    130                 135                 140                 


Thr Ala Val Asp Ser Ala Leu Arg Phe Ser Glu Phe Tyr Asn Asn Val 
145                 150                 155                 160 


Leu Gly Arg Pro Gln Lys Lys Arg Ile Ile Val Arg Tyr Asp Gly Tyr 
                165                 170                 175     


His Gly Ser Thr Ala Leu Thr Ala Ala Cys Thr Gly Arg Thr Gly Asn 
            180                 185                 190         


Trp Pro Asn Phe Asp Ile Ala Gln Asp Arg Ile Ser Phe Leu Ser Ser 
        195                 200                 205             


Pro Asn Pro Arg His Ala Gly Asn Arg Ser Gln Glu Ala Phe Leu Asp 
    210                 215                 220                 


Asp Leu Val Gln Glu Phe Glu Asp Arg Ile Glu Ser Leu Gly Pro Asp 
225                 230                 235                 240 


Thr Ile Ala Ala Phe Leu Ala Glu Pro Ile Leu Ala Ser Gly Gly Val 
                245                 250                 255     


Ile Ile Pro Pro Ala Gly Tyr His Ala Arg Phe Lys Ala Ile Cys Glu 
            260                 265                 270         


Lys His Asp Ile Leu Tyr Ile Ser Asp Glu Val Val Thr Gly Phe Gly 
        275                 280                 285             


Arg Cys Gly Glu Trp Phe Ala Ser Glu Lys Val Phe Gly Val Val Pro 
    290                 295                 300                 


Asp Ile Ile Thr Phe Ala Lys Gly Val Thr Ser Gly Tyr Val Pro Leu 
305                 310                 315                 320 


Gly Gly Leu Ala Ile Ser Glu Ala Val Leu Ala Arg Ile Ser Gly Glu 
                325                 330                 335     


Asn Ala Lys Gly Ser Trp Phe Thr Asn Gly Tyr Thr Tyr Ser Asn Gln 
            340                 345                 350         


Pro Val Ala Cys Ala Ala Ala Leu Ala Asn Ile Glu Leu Met Glu Arg 
        355                 360                 365             


Glu Gly Ile Val Asp Gln Ala Arg Glu Met Ala Asp Tyr Phe Ala Ala 
    370                 375                 380                 


Ala Leu Ala Ser Leu Arg Asp Leu Pro Gly Val Ala Glu Thr Arg Ser 
385                 390                 395                 400 


Val Gly Leu Val Gly Cys Val Gln Cys Leu Leu Asp Pro Thr Arg Ala 
                405                 410                 415     


Asp Gly Thr Ala Glu Asp Lys Ala Phe Thr Leu Lys Ile Asp Glu Arg 
            420                 425                 430         


Cys Phe Glu Leu Gly Leu Ile Val Arg Pro Leu Gly Asp Leu Cys Val 
        435                 440                 445             


Ile Ser Pro Pro Leu Ile Ile Ser Arg Ala Gln Ile Asp Glu Met Val 
    450                 455                 460                 


Ala Ile Met Arg Gln Ala Ile Thr Glu Val Ser Ala Ala His Gly Leu 
465                 470                 475                 480 


Thr Ala Lys Glu Pro Ala Ala Val 
                485             


<210>  95
<211>  837
<212>  DNA
<213>  Legionella pneumophila


<220>
<221>  CDS
<222>  (1)..(837)

<400>  95
atg agt atc gca ttt gtt aac ggc aag tat tgt tgt caa tct gaa gca       48
Met Ser Ile Ala Phe Val Asn Gly Lys Tyr Cys Cys Gln Ser Glu Ala         
1               5                   10                  15              

aaa att tca ata ttt gat cga ggg ttt ctt ttt ggt gac tcg gtt tat       96
Lys Ile Ser Ile Phe Asp Arg Gly Phe Leu Phe Gly Asp Ser Val Tyr         
            20                  25                  30                  

gaa gtg ctg cct gtt tac cat ggg cag cct tac ttt gta gac caa cat      144
Glu Val Leu Pro Val Tyr His Gly Gln Pro Tyr Phe Val Asp Gln His         
        35                  40                  45                      

ctt gac cga tta ttc tca aat atg aaa aaa att aag atg att ata cca      192
Leu Asp Arg Leu Phe Ser Asn Met Lys Lys Ile Lys Met Ile Ile Pro         
    50                  55                  60                          

aat tat gat tgg cat ggt tta att cat aga cta ata tca gaa aat aat      240
Asn Tyr Asp Trp His Gly Leu Ile His Arg Leu Ile Ser Glu Asn Asn         
65                  70                  75                  80          

ggc ggt aat tta caa gta tat atc caa gtc aca cga ggg aat caa ggg      288
Gly Gly Asn Leu Gln Val Tyr Ile Gln Val Thr Arg Gly Asn Gln Gly         
                85                  90                  95              

gtg cgc aag cat gat atc cct act tcc atc aca cct tct gtt atc gca      336
Val Arg Lys His Asp Ile Pro Thr Ser Ile Thr Pro Ser Val Ile Ala         
            100                 105                 110                 

ttc act atg cat aat cca ttt ccc acc ctc gaa gat aag gaa cag gga      384
Phe Thr Met His Asn Pro Phe Pro Thr Leu Glu Asp Lys Glu Gln Gly         
        115                 120                 125                     

atg tca gca aaa ctg gtt gaa gat ttt cgg tgg atg aga tgt gat ata      432
Met Ser Ala Lys Leu Val Glu Asp Phe Arg Trp Met Arg Cys Asp Ile         
    130                 135                 140                         

aaa act act tct tta att gcc aat ata tta ctg aat gat gag gct gta      480
Lys Thr Thr Ser Leu Ile Ala Asn Ile Leu Leu Asn Asp Glu Ala Val         
145                 150                 155                 160         

tct gca gga ttc cac act gca att ctt gcc cgg aac ggt cta att aca      528
Ser Ala Gly Phe His Thr Ala Ile Leu Ala Arg Asn Gly Leu Ile Thr         
                165                 170                 175             

gag gga agt agt acc aac gta ttt att gtc gca cag gat ggt gtt att      576
Glu Gly Ser Ser Thr Asn Val Phe Ile Val Ala Gln Asp Gly Val Ile         
            180                 185                 190                 

aag aca cca ccc atg aat aat ttc tgt tta cca gga att act cgg caa      624
Lys Thr Pro Pro Met Asn Asn Phe Cys Leu Pro Gly Ile Thr Arg Gln         
        195                 200                 205                     

gtt gtt att gaa ata att aaa aaa tta gat tta aag ttc aga gaa ata      672
Val Val Ile Glu Ile Ile Lys Lys Leu Asp Leu Lys Phe Arg Glu Ile         
    210                 215                 220                         

gaa att agc att tca gag ctt ttt tct gct cag gaa gtt tgg ata aca      720
Glu Ile Ser Ile Ser Glu Leu Phe Ser Ala Gln Glu Val Trp Ile Thr         
225                 230                 235                 240         

agt acg aca aaa gaa gta ttc cct att aca aag att aat gac tct ttg      768
Ser Thr Thr Lys Glu Val Phe Pro Ile Thr Lys Ile Asn Asp Ser Leu         
                245                 250                 255             

att aat ggc gga aaa gtt ggc gaa tat tgg cgg ata att aat gat tcc      816
Ile Asn Gly Gly Lys Val Gly Glu Tyr Trp Arg Ile Ile Asn Asp Ser         
            260                 265                 270                 

tac caa caa cta gta aac taa                                          837
Tyr Gln Gln Leu Val Asn                                                 
        275                                                             


<210>  96
<211>  278
<212>  PRT
<213>  Legionella pneumophila

<400>  96

Met Ser Ile Ala Phe Val Asn Gly Lys Tyr Cys Cys Gln Ser Glu Ala 
1               5                   10                  15      


Lys Ile Ser Ile Phe Asp Arg Gly Phe Leu Phe Gly Asp Ser Val Tyr 
            20                  25                  30          


Glu Val Leu Pro Val Tyr His Gly Gln Pro Tyr Phe Val Asp Gln His 
        35                  40                  45              


Leu Asp Arg Leu Phe Ser Asn Met Lys Lys Ile Lys Met Ile Ile Pro 
    50                  55                  60                  


Asn Tyr Asp Trp His Gly Leu Ile His Arg Leu Ile Ser Glu Asn Asn 
65                  70                  75                  80  


Gly Gly Asn Leu Gln Val Tyr Ile Gln Val Thr Arg Gly Asn Gln Gly 
                85                  90                  95      


Val Arg Lys His Asp Ile Pro Thr Ser Ile Thr Pro Ser Val Ile Ala 
            100                 105                 110         


Phe Thr Met His Asn Pro Phe Pro Thr Leu Glu Asp Lys Glu Gln Gly 
        115                 120                 125             


Met Ser Ala Lys Leu Val Glu Asp Phe Arg Trp Met Arg Cys Asp Ile 
    130                 135                 140                 


Lys Thr Thr Ser Leu Ile Ala Asn Ile Leu Leu Asn Asp Glu Ala Val 
145                 150                 155                 160 


Ser Ala Gly Phe His Thr Ala Ile Leu Ala Arg Asn Gly Leu Ile Thr 
                165                 170                 175     


Glu Gly Ser Ser Thr Asn Val Phe Ile Val Ala Gln Asp Gly Val Ile 
            180                 185                 190         


Lys Thr Pro Pro Met Asn Asn Phe Cys Leu Pro Gly Ile Thr Arg Gln 
        195                 200                 205             


Val Val Ile Glu Ile Ile Lys Lys Leu Asp Leu Lys Phe Arg Glu Ile 
    210                 215                 220                 


Glu Ile Ser Ile Ser Glu Leu Phe Ser Ala Gln Glu Val Trp Ile Thr 
225                 230                 235                 240 


Ser Thr Thr Lys Glu Val Phe Pro Ile Thr Lys Ile Asn Asp Ser Leu 
                245                 250                 255     


Ile Asn Gly Gly Lys Val Gly Glu Tyr Trp Arg Ile Ile Asn Asp Ser 
            260                 265                 270         


Tyr Gln Gln Leu Val Asn 
        275             


<210>  97
<211>  861
<212>  DNA
<213>  Nitrosomonas europaea


<220>
<221>  CDS
<222>  (1)..(861)

<400>  97
atg att tac ctc aat ggc aaa ttt ctg ccg atg gaa cag gct acc gtt       48
Met Ile Tyr Leu Asn Gly Lys Phe Leu Pro Met Glu Gln Ala Thr Val         
1               5                   10                  15              

cca gtg ctg gat aga ggc ttc atc ttc ggt gat ggt gtc tat gaa gtc       96
Pro Val Leu Asp Arg Gly Phe Ile Phe Gly Asp Gly Val Tyr Glu Val         
            20                  25                  30                  

ata ccg gtt tat tca cgt aaa ccg ttc cgg ctg ggc gaa cat ctt tcc      144
Ile Pro Val Tyr Ser Arg Lys Pro Phe Arg Leu Gly Glu His Leu Ser         
        35                  40                  45                      

cgg ctg cag cac agt ctg gat ggc ata cgt ctc cag aat ccg cac act      192
Arg Leu Gln His Ser Leu Asp Gly Ile Arg Leu Gln Asn Pro His Thr         
    50                  55                  60                          

gaa gaa caa tgg gct ggt ctg atc gaa cgc atc atc gag ctg aat gaa      240
Glu Glu Gln Trp Ala Gly Leu Ile Glu Arg Ile Ile Glu Leu Asn Glu         
65                  70                  75                  80          

ggt gat gat cag tac ctt tac ctg cac att aca cgc ggg gtg gca aaa      288
Gly Asp Asp Gln Tyr Leu Tyr Leu His Ile Thr Arg Gly Val Ala Lys         
                85                  90                  95              

cgt gac cat gcc ttt cct cgc gaa gta acg ccc act gtc ttc atc atg      336
Arg Asp His Ala Phe Pro Arg Glu Val Thr Pro Thr Val Phe Ile Met         
            100                 105                 110                 

agc aac ccg ctt ccg gct cca cct gca aaa ttg ctc gtt tcc gga gtt      384
Ser Asn Pro Leu Pro Ala Pro Pro Ala Lys Leu Leu Val Ser Gly Val         
        115                 120                 125                     

tca gcg att acc gcc agg gat aat cgc tgg ggg cgc tgt gat atc aaa      432
Ser Ala Ile Thr Ala Arg Asp Asn Arg Trp Gly Arg Cys Asp Ile Lys         
    130                 135                 140                         

gcc att tca ctg ttg cca aat atc tta ttg cgc cag ctt gcc gtg gac      480
Ala Ile Ser Leu Leu Pro Asn Ile Leu Leu Arg Gln Leu Ala Val Asp         
145                 150                 155                 160         

gca caa gcc atg gaa acg atc ctg tta cgc gat ggt ctg ttg acc gaa      528
Ala Gln Ala Met Glu Thr Ile Leu Leu Arg Asp Gly Leu Leu Thr Glu         
                165                 170                 175             

ggg gcc gcc agc aat att ttc atc gta aaa gac gac ctg ctg ctg acc      576
Gly Ala Ala Ser Asn Ile Phe Ile Val Lys Asp Asp Leu Leu Leu Thr         
            180                 185                 190                 

ccc ccc aaa gat cac cgt ata ttg cct ggc att act tat gat gta gta      624
Pro Pro Lys Asp His Arg Ile Leu Pro Gly Ile Thr Tyr Asp Val Val         
        195                 200                 205                     

ctg gaa ctg gct gaa aca cat ggt gtt cca cat gcg aca aga gaa ata      672
Leu Glu Leu Ala Glu Thr His Gly Val Pro His Ala Thr Arg Glu Ile         
    210                 215                 220                         

tca gag ctt gag tta cgt act gca cgg gaa atc atg ctg act tct tcc      720
Ser Glu Leu Glu Leu Arg Thr Ala Arg Glu Ile Met Leu Thr Ser Ser         
225                 230                 235                 240         

acc aaa gaa att ctc ccg atc aca cag ctg gat gga caa ccg atc ggt      768
Thr Lys Glu Ile Leu Pro Ile Thr Gln Leu Asp Gly Gln Pro Ile Gly         
                245                 250                 255             

aat ggc acc cca ggg cca gta ttt cag caa ctg gat cgg ctc tat cag      816
Asn Gly Thr Pro Gly Pro Val Phe Gln Gln Leu Asp Arg Leu Tyr Gln         
            260                 265                 270                 

gca tat aag ctg gaa gtc atg cgc ggg cat gct cca cgc cag taa          861
Ala Tyr Lys Leu Glu Val Met Arg Gly His Ala Pro Arg Gln                 
        275                 280                 285                     


<210>  98
<211>  286
<212>  PRT
<213>  Nitrosomonas europaea

<400>  98

Met Ile Tyr Leu Asn Gly Lys Phe Leu Pro Met Glu Gln Ala Thr Val 
1               5                   10                  15      


Pro Val Leu Asp Arg Gly Phe Ile Phe Gly Asp Gly Val Tyr Glu Val 
            20                  25                  30          


Ile Pro Val Tyr Ser Arg Lys Pro Phe Arg Leu Gly Glu His Leu Ser 
        35                  40                  45              


Arg Leu Gln His Ser Leu Asp Gly Ile Arg Leu Gln Asn Pro His Thr 
    50                  55                  60                  


Glu Glu Gln Trp Ala Gly Leu Ile Glu Arg Ile Ile Glu Leu Asn Glu 
65                  70                  75                  80  


Gly Asp Asp Gln Tyr Leu Tyr Leu His Ile Thr Arg Gly Val Ala Lys 
                85                  90                  95      


Arg Asp His Ala Phe Pro Arg Glu Val Thr Pro Thr Val Phe Ile Met 
            100                 105                 110         


Ser Asn Pro Leu Pro Ala Pro Pro Ala Lys Leu Leu Val Ser Gly Val 
        115                 120                 125             


Ser Ala Ile Thr Ala Arg Asp Asn Arg Trp Gly Arg Cys Asp Ile Lys 
    130                 135                 140                 


Ala Ile Ser Leu Leu Pro Asn Ile Leu Leu Arg Gln Leu Ala Val Asp 
145                 150                 155                 160 


Ala Gln Ala Met Glu Thr Ile Leu Leu Arg Asp Gly Leu Leu Thr Glu 
                165                 170                 175     


Gly Ala Ala Ser Asn Ile Phe Ile Val Lys Asp Asp Leu Leu Leu Thr 
            180                 185                 190         


Pro Pro Lys Asp His Arg Ile Leu Pro Gly Ile Thr Tyr Asp Val Val 
        195                 200                 205             


Leu Glu Leu Ala Glu Thr His Gly Val Pro His Ala Thr Arg Glu Ile 
    210                 215                 220                 


Ser Glu Leu Glu Leu Arg Thr Ala Arg Glu Ile Met Leu Thr Ser Ser 
225                 230                 235                 240 


Thr Lys Glu Ile Leu Pro Ile Thr Gln Leu Asp Gly Gln Pro Ile Gly 
                245                 250                 255     


Asn Gly Thr Pro Gly Pro Val Phe Gln Gln Leu Asp Arg Leu Tyr Gln 
            260                 265                 270         


Ala Tyr Lys Leu Glu Val Met Arg Gly His Ala Pro Arg Gln 
        275                 280                 285     


<210>  99
<211>  1293
<212>  DNA
<213>  Neisseria gonorrhoeae


<220>
<221>  CDS
<222>  (1)..(1293)

<400>  99
atg agg ata aat atg aac cgt aac gaa att tta ttc gac cgc gcc aag       48
Met Arg Ile Asn Met Asn Arg Asn Glu Ile Leu Phe Asp Arg Ala Lys         
1               5                   10                  15              

gcc atc atc ccc ggc ggc gtg aat tcg ccc gtg cgc gca ttc ggc agc       96
Ala Ile Ile Pro Gly Gly Val Asn Ser Pro Val Arg Ala Phe Gly Ser         
            20                  25                  30                  

gtc ggc ggc gtg ccg cgc ttc atc aaa aaa gcc gaa ggc gcg tat gtt      144
Val Gly Gly Val Pro Arg Phe Ile Lys Lys Ala Glu Gly Ala Tyr Val         
        35                  40                  45                      

tgg gac gaa aac ggc acg cgc tac acc gat tat gtc ggc tct tgg ggg      192
Trp Asp Glu Asn Gly Thr Arg Tyr Thr Asp Tyr Val Gly Ser Trp Gly         
    50                  55                  60                          

cct gcg att gtc gga cac gcg cat ccc gaa gtc gtc gaa gcc gtg cgc      240
Pro Ala Ile Val Gly His Ala His Pro Glu Val Val Glu Ala Val Arg         
65                  70                  75                  80          

gaa gct gcg ttg ggc ggt ttg tcg ttc ggc gcg ccc acc gaa ggc gaa      288
Glu Ala Ala Leu Gly Gly Leu Ser Phe Gly Ala Pro Thr Glu Gly Glu         
                85                  90                  95              

atc gcc att gcc gaa caa att gcc gaa att atg ccg tct gtc gaa cgg      336
Ile Ala Ile Ala Glu Gln Ile Ala Glu Ile Met Pro Ser Val Glu Arg         
            100                 105                 110                 

ctg cgc ctc gtc agc tcc ggc acg gaa gcg acg atg act gcc atc cgt      384
Leu Arg Leu Val Ser Ser Gly Thr Glu Ala Thr Met Thr Ala Ile Arg         
        115                 120                 125                     

ctg gca cgc ggt ttt acc ggc cgc gac aaa atc atc aaa ttt gaa ggc      432
Leu Ala Arg Gly Phe Thr Gly Arg Asp Lys Ile Ile Lys Phe Glu Gly         
    130                 135                 140                         

tgc tac cac ggc cat tcc gac agc ctg ttg gtg aaa gca ggc agc ggt      480
Cys Tyr His Gly His Ser Asp Ser Leu Leu Val Lys Ala Gly Ser Gly         
145                 150                 155                 160         

ctg ctt acc ttc ggc aat cct tct tcc gcc ggt gtg cct gcc gac ttt      528
Leu Leu Thr Phe Gly Asn Pro Ser Ser Ala Gly Val Pro Ala Asp Phe         
                165                 170                 175             

acc aaa cat act ttg gta ctc gaa tac aac aac atc gcc caa ctc gaa      576
Thr Lys His Thr Leu Val Leu Glu Tyr Asn Asn Ile Ala Gln Leu Glu         
            180                 185                 190                 

gaa gcc ttt gcc caa agc ggc gac gaa atc gcc tgc gtg att gtc gaa      624
Glu Ala Phe Ala Gln Ser Gly Asp Glu Ile Ala Cys Val Ile Val Glu         
        195                 200                 205                     

ccc ttc gtc ggc aat atg aac ctc gtc cgc ccg acc gaa gcc ttt gtc      672
Pro Phe Val Gly Asn Met Asn Leu Val Arg Pro Thr Glu Ala Phe Val         
    210                 215                 220                         

aaa gcc ttg cgc gga ttg acc gaa aaa cac ggc gcg gtg ttg att tac      720
Lys Ala Leu Arg Gly Leu Thr Glu Lys His Gly Ala Val Leu Ile Tyr         
225                 230                 235                 240         

gac gaa gtg atg acc ggt ttc cgc gtc gcg ctc ggc ggc gcg cag tcg      768
Asp Glu Val Met Thr Gly Phe Arg Val Ala Leu Gly Gly Ala Gln Ser         
                245                 250                 255             

ctg cac ggc atc acg ccc gac ctg acc acg atg ggc aaa gtc atc ggc      816
Leu His Gly Ile Thr Pro Asp Leu Thr Thr Met Gly Lys Val Ile Gly         
            260                 265                 270                 

ggc ggt atg ccg ctt gcc gcg ttc ggc gga cgc aaa gac atc atg gaa      864
Gly Gly Met Pro Leu Ala Ala Phe Gly Gly Arg Lys Asp Ile Met Glu         
        275                 280                 285                     

tgt att tcc ccg ttg ggc ggc gtg tat cag gca ggt aca tta tca ggc      912
Cys Ile Ser Pro Leu Gly Gly Val Tyr Gln Ala Gly Thr Leu Ser Gly         
    290                 295                 300                         

aac ccg att gcc gtc gcc gcc ggc ttg aaa acg ctg gaa atc atc cag      960
Asn Pro Ile Ala Val Ala Ala Gly Leu Lys Thr Leu Glu Ile Ile Gln         
305                 310                 315                 320         

cgc gaa ggc ttc tat gaa aac ctg acc gcc ttg aca caa cgc ctt gcc     1008
Arg Glu Gly Phe Tyr Glu Asn Leu Thr Ala Leu Thr Gln Arg Leu Ala         
                325                 330                 335             

aac ggt att gcc gcc gcc aaa gcg cac ggt atc gag ttt gcc gcc gac     1056
Asn Gly Ile Ala Ala Ala Lys Ala His Gly Ile Glu Phe Ala Ala Asp         
            340                 345                 350                 

agc gtg ggc ggt atg ttc ggt ctg tat ttc gcc gca cac gtg ccg cga     1104
Ser Val Gly Gly Met Phe Gly Leu Tyr Phe Ala Ala His Val Pro Arg         
        355                 360                 365                     

aac tat gcc gat atg gcg cgc tcc aat atc gac gct ttc aaa cgc ttc     1152
Asn Tyr Ala Asp Met Ala Arg Ser Asn Ile Asp Ala Phe Lys Arg Phe         
    370                 375                 380                         

ttc cac ggc atg ctc gac cgc ggc att gcc ttc ggc ccg tcc gct tat     1200
Phe His Gly Met Leu Asp Arg Gly Ile Ala Phe Gly Pro Ser Ala Tyr         
385                 390                 395                 400         

gaa gcg ggt ttc gtt tcc gcc gcg cat acg ccc gag ctg att gac gaa     1248
Glu Ala Gly Phe Val Ser Ala Ala His Thr Pro Glu Leu Ile Asp Glu         
                405                 410                 415             

acg gtt gcg gtt gcg gtt gaa gtg ttc aag gcg atg gct gca tga         1293
Thr Val Ala Val Ala Val Glu Val Phe Lys Ala Met Ala Ala                 
            420                 425                 430                 


<210>  100
<211>  430
<212>  PRT
<213>  Neisseria gonorrhoeae

<400>  100

Met Arg Ile Asn Met Asn Arg Asn Glu Ile Leu Phe Asp Arg Ala Lys 
1               5                   10                  15      


Ala Ile Ile Pro Gly Gly Val Asn Ser Pro Val Arg Ala Phe Gly Ser 
            20                  25                  30          


Val Gly Gly Val Pro Arg Phe Ile Lys Lys Ala Glu Gly Ala Tyr Val 
        35                  40                  45              


Trp Asp Glu Asn Gly Thr Arg Tyr Thr Asp Tyr Val Gly Ser Trp Gly 
    50                  55                  60                  


Pro Ala Ile Val Gly His Ala His Pro Glu Val Val Glu Ala Val Arg 
65                  70                  75                  80  


Glu Ala Ala Leu Gly Gly Leu Ser Phe Gly Ala Pro Thr Glu Gly Glu 
                85                  90                  95      


Ile Ala Ile Ala Glu Gln Ile Ala Glu Ile Met Pro Ser Val Glu Arg 
            100                 105                 110         


Leu Arg Leu Val Ser Ser Gly Thr Glu Ala Thr Met Thr Ala Ile Arg 
        115                 120                 125             


Leu Ala Arg Gly Phe Thr Gly Arg Asp Lys Ile Ile Lys Phe Glu Gly 
    130                 135                 140                 


Cys Tyr His Gly His Ser Asp Ser Leu Leu Val Lys Ala Gly Ser Gly 
145                 150                 155                 160 


Leu Leu Thr Phe Gly Asn Pro Ser Ser Ala Gly Val Pro Ala Asp Phe 
                165                 170                 175     


Thr Lys His Thr Leu Val Leu Glu Tyr Asn Asn Ile Ala Gln Leu Glu 
            180                 185                 190         


Glu Ala Phe Ala Gln Ser Gly Asp Glu Ile Ala Cys Val Ile Val Glu 
        195                 200                 205             


Pro Phe Val Gly Asn Met Asn Leu Val Arg Pro Thr Glu Ala Phe Val 
    210                 215                 220                 


Lys Ala Leu Arg Gly Leu Thr Glu Lys His Gly Ala Val Leu Ile Tyr 
225                 230                 235                 240 


Asp Glu Val Met Thr Gly Phe Arg Val Ala Leu Gly Gly Ala Gln Ser 
                245                 250                 255     


Leu His Gly Ile Thr Pro Asp Leu Thr Thr Met Gly Lys Val Ile Gly 
            260                 265                 270         


Gly Gly Met Pro Leu Ala Ala Phe Gly Gly Arg Lys Asp Ile Met Glu 
        275                 280                 285             


Cys Ile Ser Pro Leu Gly Gly Val Tyr Gln Ala Gly Thr Leu Ser Gly 
    290                 295                 300                 


Asn Pro Ile Ala Val Ala Ala Gly Leu Lys Thr Leu Glu Ile Ile Gln 
305                 310                 315                 320 


Arg Glu Gly Phe Tyr Glu Asn Leu Thr Ala Leu Thr Gln Arg Leu Ala 
                325                 330                 335     


Asn Gly Ile Ala Ala Ala Lys Ala His Gly Ile Glu Phe Ala Ala Asp 
            340                 345                 350         


Ser Val Gly Gly Met Phe Gly Leu Tyr Phe Ala Ala His Val Pro Arg 
        355                 360                 365             


Asn Tyr Ala Asp Met Ala Arg Ser Asn Ile Asp Ala Phe Lys Arg Phe 
    370                 375                 380                 


Phe His Gly Met Leu Asp Arg Gly Ile Ala Phe Gly Pro Ser Ala Tyr 
385                 390                 395                 400 


Glu Ala Gly Phe Val Ser Ala Ala His Thr Pro Glu Leu Ile Asp Glu 
                405                 410                 415     


Thr Val Ala Val Ala Val Glu Val Phe Lys Ala Met Ala Ala 
            420                 425                 430 


<210>  101
<211>  924
<212>  DNA
<213>  Pseudomonas aeruginosa


<220>
<221>  CDS
<222>  (1)..(924)

<400>  101
atg tcg atg gcc gat cgt gat ggc gtg atc tgg tat gac ggt gaa ctg       48
Met Ser Met Ala Asp Arg Asp Gly Val Ile Trp Tyr Asp Gly Glu Leu         
1               5                   10                  15              

gtg cag tgg cgc gac gcg acc acg cac gtg ctg acc cat acc ctg cac       96
Val Gln Trp Arg Asp Ala Thr Thr His Val Leu Thr His Thr Leu His         
            20                  25                  30                  

tat gga atg ggc gtg ttc gag ggc gtg cgc gcc tac gac acc ccg cag      144
Tyr Gly Met Gly Val Phe Glu Gly Val Arg Ala Tyr Asp Thr Pro Gln         
        35                  40                  45                      

ggc acg gcg atc ttc cgc ctg cag gcg cat acc gac cgg ctg ttc gac      192
Gly Thr Ala Ile Phe Arg Leu Gln Ala His Thr Asp Arg Leu Phe Asp         
    50                  55                  60                          

tcc gcg cac atc atg aac atg cag atc ccg tac agc cgc gac gag atc      240
Ser Ala His Ile Met Asn Met Gln Ile Pro Tyr Ser Arg Asp Glu Ile         
65                  70                  75                  80          

aac gag gcg acc cgc gcc gcc gtg cgc gag aac aac ctg gaa agc gcc      288
Asn Glu Ala Thr Arg Ala Ala Val Arg Glu Asn Asn Leu Glu Ser Ala         
                85                  90                  95              

tat atc cgc ccg atg gtg ttc tac gga agc gaa ggc atg ggc ctg cgc      336
Tyr Ile Arg Pro Met Val Phe Tyr Gly Ser Glu Gly Met Gly Leu Arg         
            100                 105                 110                 

gcc agc ggc ctg aag gtc cat gtg atc atc gcc gcc tgg agc tgg ggc      384
Ala Ser Gly Leu Lys Val His Val Ile Ile Ala Ala Trp Ser Trp Gly         
        115                 120                 125                     

gcc tac atg ggc gag gaa gcc ctg cag caa ggc atc aag gtg cgc acc      432
Ala Tyr Met Gly Glu Glu Ala Leu Gln Gln Gly Ile Lys Val Arg Thr         
    130                 135                 140                         

agt tcc ttc acc cgc cac cac gtc aac atc tcg atg acc cgc gcc aag      480
Ser Ser Phe Thr Arg His His Val Asn Ile Ser Met Thr Arg Ala Lys         
145                 150                 155                 160         

tcc aac ggc gcc tac atc aac tcg atg ctg gcc ctc cag gaa gcg atc      528
Ser Asn Gly Ala Tyr Ile Asn Ser Met Leu Ala Leu Gln Glu Ala Ile         
                165                 170                 175             

tcc ggc ggc gcc gac gag gcc atg atg ctc gat ccg gaa ggc tac gtg      576
Ser Gly Gly Ala Asp Glu Ala Met Met Leu Asp Pro Glu Gly Tyr Val         
            180                 185                 190                 

gcc gaa ggc tcc ggc gag aac atc ttc atc atc aag gat ggc gtg atc      624
Ala Glu Gly Ser Gly Glu Asn Ile Phe Ile Ile Lys Asp Gly Val Ile         
        195                 200                 205                     

tac acc ccg gaa gtc acc gcc tgc ctg aac ggc atc act cgt aac act      672
Tyr Thr Pro Glu Val Thr Ala Cys Leu Asn Gly Ile Thr Arg Asn Thr         
    210                 215                 220                         

atc ctg acc ctg gcc gcc gaa cac ggt ttt aaa ctg gtc gag aag cgc      720
Ile Leu Thr Leu Ala Ala Glu His Gly Phe Lys Leu Val Glu Lys Arg         
225                 230                 235                 240         

atc acc cgc gac gag gtg tac atc gcc gac gag gcc ttc ttc act ggc      768
Ile Thr Arg Asp Glu Val Tyr Ile Ala Asp Glu Ala Phe Phe Thr Gly         
                245                 250                 255             

act gcc gcg gaa gtc acg ccg atc cgc gaa gtg gac ggt cgc aag atc      816
Thr Ala Ala Glu Val Thr Pro Ile Arg Glu Val Asp Gly Arg Lys Ile         
            260                 265                 270                 

ggc gcc ggc cgc cgt ggc ccg gtc acc gaa aag ctg cag aaa gcc tat      864
Gly Ala Gly Arg Arg Gly Pro Val Thr Glu Lys Leu Gln Lys Ala Tyr         
        275                 280                 285                     

ttc gac ctg gtc agc ggc aag acc gag gcc cac gcc gag tgg cgt acc      912
Phe Asp Leu Val Ser Gly Lys Thr Glu Ala His Ala Glu Trp Arg Thr         
    290                 295                 300                         

ctg gtc aag taa                                                      924
Leu Val Lys                                                             
305                                                                     


<210>  102
<211>  307
<212>  PRT
<213>  Pseudomonas aeruginosa

<400>  102

Met Ser Met Ala Asp Arg Asp Gly Val Ile Trp Tyr Asp Gly Glu Leu 
1               5                   10                  15      


Val Gln Trp Arg Asp Ala Thr Thr His Val Leu Thr His Thr Leu His 
            20                  25                  30          


Tyr Gly Met Gly Val Phe Glu Gly Val Arg Ala Tyr Asp Thr Pro Gln 
        35                  40                  45              


Gly Thr Ala Ile Phe Arg Leu Gln Ala His Thr Asp Arg Leu Phe Asp 
    50                  55                  60                  


Ser Ala His Ile Met Asn Met Gln Ile Pro Tyr Ser Arg Asp Glu Ile 
65                  70                  75                  80  


Asn Glu Ala Thr Arg Ala Ala Val Arg Glu Asn Asn Leu Glu Ser Ala 
                85                  90                  95      


Tyr Ile Arg Pro Met Val Phe Tyr Gly Ser Glu Gly Met Gly Leu Arg 
            100                 105                 110         


Ala Ser Gly Leu Lys Val His Val Ile Ile Ala Ala Trp Ser Trp Gly 
        115                 120                 125             


Ala Tyr Met Gly Glu Glu Ala Leu Gln Gln Gly Ile Lys Val Arg Thr 
    130                 135                 140                 


Ser Ser Phe Thr Arg His His Val Asn Ile Ser Met Thr Arg Ala Lys 
145                 150                 155                 160 


Ser Asn Gly Ala Tyr Ile Asn Ser Met Leu Ala Leu Gln Glu Ala Ile 
                165                 170                 175     


Ser Gly Gly Ala Asp Glu Ala Met Met Leu Asp Pro Glu Gly Tyr Val 
            180                 185                 190         


Ala Glu Gly Ser Gly Glu Asn Ile Phe Ile Ile Lys Asp Gly Val Ile 
        195                 200                 205             


Tyr Thr Pro Glu Val Thr Ala Cys Leu Asn Gly Ile Thr Arg Asn Thr 
    210                 215                 220                 


Ile Leu Thr Leu Ala Ala Glu His Gly Phe Lys Leu Val Glu Lys Arg 
225                 230                 235                 240 


Ile Thr Arg Asp Glu Val Tyr Ile Ala Asp Glu Ala Phe Phe Thr Gly 
                245                 250                 255     


Thr Ala Ala Glu Val Thr Pro Ile Arg Glu Val Asp Gly Arg Lys Ile 
            260                 265                 270         


Gly Ala Gly Arg Arg Gly Pro Val Thr Glu Lys Leu Gln Lys Ala Tyr 
        275                 280                 285             


Phe Asp Leu Val Ser Gly Lys Thr Glu Ala His Ala Glu Trp Arg Thr 
    290                 295                 300                 


Leu Val Lys 
305         


<210>  103
<211>  1407
<212>  DNA
<213>  Rhodopseudomonas palustris


<220>
<221>  CDS
<222>  (1)..(1407)

<400>  103
atg aag ctg ata ccg tgc cgc gcc ttt cac ccc ccg gcc gcg cag tgc       48
Met Lys Leu Ile Pro Cys Arg Ala Phe His Pro Pro Ala Ala Gln Cys         
1               5                   10                  15              

atg agg agc gcc atg tta gac aag atc aag ccc acg tcc gcc gtc aac       96
Met Arg Ser Ala Met Leu Asp Lys Ile Lys Pro Thr Ser Ala Val Asn         
            20                  25                  30                  

gcg ccg aac gat ctc aac gcg ttc tgg atg ccg ttc acc gcg aac cgg      144
Ala Pro Asn Asp Leu Asn Ala Phe Trp Met Pro Phe Thr Ala Asn Arg         
        35                  40                  45                      

gcc ttc aag cgc gcg ccg aag atg gtc gtg ggt gcc gaa ggc atg cac      192
Ala Phe Lys Arg Ala Pro Lys Met Val Val Gly Ala Glu Gly Met His         
    50                  55                  60                          

tac atc acc gcc gat ggt cgc aag atc atc gac gcc gcc tcg ggc atg      240
Tyr Ile Thr Ala Asp Gly Arg Lys Ile Ile Asp Ala Ala Ser Gly Met         
65                  70                  75                  80          

tgg tgc acc aat gcg ggc cat ggc cgc aag gaa atc gcc gag gcg atc      288
Trp Cys Thr Asn Ala Gly His Gly Arg Lys Glu Ile Ala Glu Ala Ile         
                85                  90                  95              

aag gcg cag gcc gat gaa ctc gac ttc tcg ccg ccg ttc cag ttc ggc      336
Lys Ala Gln Ala Asp Glu Leu Asp Phe Ser Pro Pro Phe Gln Phe Gly         
            100                 105                 110                 

cag ccg aag gcg ttc gaa ctc gcc agc cgg atc gcc gat ctg gcg ccg      384
Gln Pro Lys Ala Phe Glu Leu Ala Ser Arg Ile Ala Asp Leu Ala Pro         
        115                 120                 125                     

gaa ggc ctc gat cac gtg ttc ttc tgc aat tcg ggc tcg gaa gcc ggc      432
Glu Gly Leu Asp His Val Phe Phe Cys Asn Ser Gly Ser Glu Ala Gly         
    130                 135                 140                         

gac acc gcg ctg aag atc gcg gtc gcc tat cag cag atc aag ggc cag      480
Asp Thr Ala Leu Lys Ile Ala Val Ala Tyr Gln Gln Ile Lys Gly Gln         
145                 150                 155                 160         

ggc tca cgc acc cgc ctg atc ggc cgc gag cgc ggc tat cac ggc gtc      528
Gly Ser Arg Thr Arg Leu Ile Gly Arg Glu Arg Gly Tyr His Gly Val         
                165                 170                 175             

ggc ttc ggc ggc acc gcg gtc ggc ggc atc ggc aac aac cgc aag atg      576
Gly Phe Gly Gly Thr Ala Val Gly Gly Ile Gly Asn Asn Arg Lys Met         
            180                 185                 190                 

ttc ggt ccg ctg ctc aac ggc gtc gat cat ctg cct gcg act tat gat      624
Phe Gly Pro Leu Leu Asn Gly Val Asp His Leu Pro Ala Thr Tyr Asp         
        195                 200                 205                     

cgc gac aag cag gct ttc acc atc ggc gag ccg gaa tac ggc gcg cac      672
Arg Asp Lys Gln Ala Phe Thr Ile Gly Glu Pro Glu Tyr Gly Ala His         
    210                 215                 220                         

ttc gcc gaa gcg ctt gaa ggc ctc gtc aat ctg cac ggc gcc aac acc      720
Phe Ala Glu Ala Leu Glu Gly Leu Val Asn Leu His Gly Ala Asn Thr         
225                 230                 235                 240         

atc gcg gcg gtg atc gtc gag ccg atg gcc ggc tcc acc ggc gtg ctg      768
Ile Ala Ala Val Ile Val Glu Pro Met Ala Gly Ser Thr Gly Val Leu         
                245                 250                 255             

ccg gcg ccg aag ggc tat ctc aag aag ctg cgc gag atc acc aag aag      816
Pro Ala Pro Lys Gly Tyr Leu Lys Lys Leu Arg Glu Ile Thr Lys Lys         
            260                 265                 270                 

cac ggc atc ctg ctg atc ttc gac gag gtc atc acc ggc tac ggc cgt      864
His Gly Ile Leu Leu Ile Phe Asp Glu Val Ile Thr Gly Tyr Gly Arg         
        275                 280                 285                     

ctc ggc tat gcc ttc gcg tcc gaa cgt tac ggc gtc acc ccg gac atg      912
Leu Gly Tyr Ala Phe Ala Ser Glu Arg Tyr Gly Val Thr Pro Asp Met         
    290                 295                 300                         

atc acc ttc gcc aag ggc gtc acc aat ggt gcg gtg ccg atg ggc ggc      960
Ile Thr Phe Ala Lys Gly Val Thr Asn Gly Ala Val Pro Met Gly Gly         
305                 310                 315                 320         

gtg atc acc tcg gcg gag atc cac gat gcg ttc atg acc ggc ccc gag     1008
Val Ile Thr Ser Ala Glu Ile His Asp Ala Phe Met Thr Gly Pro Glu         
                325                 330                 335             

cac gcg gtc gag ctg gcg cac ggc tac acc tat tcg gcg cat ccg ctc     1056
His Ala Val Glu Leu Ala His Gly Tyr Thr Tyr Ser Ala His Pro Leu         
            340                 345                 350                 

gcc tgc gcg gcc ggc atc gcc acc ctc gac atc tac cgc gac gag aag     1104
Ala Cys Ala Ala Gly Ile Ala Thr Leu Asp Ile Tyr Arg Asp Glu Lys         
        355                 360                 365                     

ctg ttc gag cgc gcc aag gcg ctg gag ccg aag ttt gcc gag gcg gtg     1152
Leu Phe Glu Arg Ala Lys Ala Leu Glu Pro Lys Phe Ala Glu Ala Val         
    370                 375                 380                         

atg tcg ctg aag tcg gcc ccg aac gtg gtc gac atc cgc acc gtc ggc     1200
Met Ser Leu Lys Ser Ala Pro Asn Val Val Asp Ile Arg Thr Val Gly         
385                 390                 395                 400         

ctg acg gcg ggt atc gac ctc gct tcg atc gcc gat gcg gtc ggc aag     1248
Leu Thr Ala Gly Ile Asp Leu Ala Ser Ile Ala Asp Ala Val Gly Lys         
                405                 410                 415             

cgt ggc ttc gaa gcg atg aat gcc ggc ttc cac gac cac gag ctg atg     1296
Arg Gly Phe Glu Ala Met Asn Ala Gly Phe His Asp His Glu Leu Met         
            420                 425                 430                 

ctg cgg atc gcc ggc gac acc ctg gcg ctg acc ccg ccg ctg atc ctc     1344
Leu Arg Ile Ala Gly Asp Thr Leu Ala Leu Thr Pro Pro Leu Ile Leu         
        435                 440                 445                     

agc gag gac cac atc ggt gag atc gtc gac aag gtc ggc aag gtg atc     1392
Ser Glu Asp His Ile Gly Glu Ile Val Asp Lys Val Gly Lys Val Ile         
    450                 455                 460                         

cgc gcg gtc gcc tga                                                 1407
Arg Ala Val Ala                                                         
465                                                                     


<210>  104
<211>  468
<212>  PRT
<213>  Rhodopseudomonas palustris

<400>  104

Met Lys Leu Ile Pro Cys Arg Ala Phe His Pro Pro Ala Ala Gln Cys 
1               5                   10                  15      


Met Arg Ser Ala Met Leu Asp Lys Ile Lys Pro Thr Ser Ala Val Asn 
            20                  25                  30          


Ala Pro Asn Asp Leu Asn Ala Phe Trp Met Pro Phe Thr Ala Asn Arg 
        35                  40                  45              


Ala Phe Lys Arg Ala Pro Lys Met Val Val Gly Ala Glu Gly Met His 
    50                  55                  60                  


Tyr Ile Thr Ala Asp Gly Arg Lys Ile Ile Asp Ala Ala Ser Gly Met 
65                  70                  75                  80  


Trp Cys Thr Asn Ala Gly His Gly Arg Lys Glu Ile Ala Glu Ala Ile 
                85                  90                  95      


Lys Ala Gln Ala Asp Glu Leu Asp Phe Ser Pro Pro Phe Gln Phe Gly 
            100                 105                 110         


Gln Pro Lys Ala Phe Glu Leu Ala Ser Arg Ile Ala Asp Leu Ala Pro 
        115                 120                 125             


Glu Gly Leu Asp His Val Phe Phe Cys Asn Ser Gly Ser Glu Ala Gly 
    130                 135                 140                 


Asp Thr Ala Leu Lys Ile Ala Val Ala Tyr Gln Gln Ile Lys Gly Gln 
145                 150                 155                 160 


Gly Ser Arg Thr Arg Leu Ile Gly Arg Glu Arg Gly Tyr His Gly Val 
                165                 170                 175     


Gly Phe Gly Gly Thr Ala Val Gly Gly Ile Gly Asn Asn Arg Lys Met 
            180                 185                 190         


Phe Gly Pro Leu Leu Asn Gly Val Asp His Leu Pro Ala Thr Tyr Asp 
        195                 200                 205             


Arg Asp Lys Gln Ala Phe Thr Ile Gly Glu Pro Glu Tyr Gly Ala His 
    210                 215                 220                 


Phe Ala Glu Ala Leu Glu Gly Leu Val Asn Leu His Gly Ala Asn Thr 
225                 230                 235                 240 


Ile Ala Ala Val Ile Val Glu Pro Met Ala Gly Ser Thr Gly Val Leu 
                245                 250                 255     


Pro Ala Pro Lys Gly Tyr Leu Lys Lys Leu Arg Glu Ile Thr Lys Lys 
            260                 265                 270         


His Gly Ile Leu Leu Ile Phe Asp Glu Val Ile Thr Gly Tyr Gly Arg 
        275                 280                 285             


Leu Gly Tyr Ala Phe Ala Ser Glu Arg Tyr Gly Val Thr Pro Asp Met 
    290                 295                 300                 


Ile Thr Phe Ala Lys Gly Val Thr Asn Gly Ala Val Pro Met Gly Gly 
305                 310                 315                 320 


Val Ile Thr Ser Ala Glu Ile His Asp Ala Phe Met Thr Gly Pro Glu 
                325                 330                 335     


His Ala Val Glu Leu Ala His Gly Tyr Thr Tyr Ser Ala His Pro Leu 
            340                 345                 350         


Ala Cys Ala Ala Gly Ile Ala Thr Leu Asp Ile Tyr Arg Asp Glu Lys 
        355                 360                 365             


Leu Phe Glu Arg Ala Lys Ala Leu Glu Pro Lys Phe Ala Glu Ala Val 
    370                 375                 380                 


Met Ser Leu Lys Ser Ala Pro Asn Val Val Asp Ile Arg Thr Val Gly 
385                 390                 395                 400 


Leu Thr Ala Gly Ile Asp Leu Ala Ser Ile Ala Asp Ala Val Gly Lys 
                405                 410                 415     


Arg Gly Phe Glu Ala Met Asn Ala Gly Phe His Asp His Glu Leu Met 
            420                 425                 430         


Leu Arg Ile Ala Gly Asp Thr Leu Ala Leu Thr Pro Pro Leu Ile Leu 
        435                 440                 445             


Ser Glu Asp His Ile Gly Glu Ile Val Asp Lys Val Gly Lys Val Ile 
    450                 455                 460                 


Arg Ala Val Ala 
465             


<210>  105
<211>  1263
<212>  DNA
<213>  Escherichia coli


<220>
<221>  CDS
<222>  (1)..(1263)

<400>  105
atg cca cat tca ctg ttc agc acc gat acc gat ctc acc gcc gaa aat       48
Met Pro His Ser Leu Phe Ser Thr Asp Thr Asp Leu Thr Ala Glu Asn         
1               5                   10                  15              

ctg ctg cgt ttg ccc gct gaa ttt ggc tgc ccg gtg tgg gtc tac gat       96
Leu Leu Arg Leu Pro Ala Glu Phe Gly Cys Pro Val Trp Val Tyr Asp         
            20                  25                  30                  

gcg caa att att cgt cgg cag att gca gcg ctg aaa cag ttt gat gtg      144
Ala Gln Ile Ile Arg Arg Gln Ile Ala Ala Leu Lys Gln Phe Asp Val         
        35                  40                  45                      

gtg cgc ttt gca cag aaa gcc tgt tcc aat att cat att ttg cgc tta      192
Val Arg Phe Ala Gln Lys Ala Cys Ser Asn Ile His Ile Leu Arg Leu         
    50                  55                  60                          

atg cgt gag cag ggc gtg aaa gtg gat tcc gtc tcg tta ggc gaa ata      240
Met Arg Glu Gln Gly Val Lys Val Asp Ser Val Ser Leu Gly Glu Ile         
65                  70                  75                  80          

gag cgt gcg ttg gcg gcg ggt tac aat ccg caa acg cac ccc gat gat      288
Glu Arg Ala Leu Ala Ala Gly Tyr Asn Pro Gln Thr His Pro Asp Asp         
                85                  90                  95              

att gtt ttt acg gca gat gtt atc gat cag gcg acg ctt gaa cgc gtc      336
Ile Val Phe Thr Ala Asp Val Ile Asp Gln Ala Thr Leu Glu Arg Val         
            100                 105                 110                 

agt gaa ttg caa att ccg gtg aat gcg ggt tct gtt gat atg ctc gac      384
Ser Glu Leu Gln Ile Pro Val Asn Ala Gly Ser Val Asp Met Leu Asp         
        115                 120                 125                     

caa ctg ggc cag gtt tcg cca ggg cat cgg gta tgg ctg cgc gtt aat      432
Gln Leu Gly Gln Val Ser Pro Gly His Arg Val Trp Leu Arg Val Asn         
    130                 135                 140                         

ccg ggg ttt ggt cac gga cat agc caa aaa acc aat acc ggt ggc gaa      480
Pro Gly Phe Gly His Gly His Ser Gln Lys Thr Asn Thr Gly Gly Glu         
145                 150                 155                 160         

aac agc aag cac ggt atc tgg tac acc gat ctg ccc gcc gca ctg gac      528
Asn Ser Lys His Gly Ile Trp Tyr Thr Asp Leu Pro Ala Ala Leu Asp         
                165                 170                 175             

gtg ata caa cgt cat cat ctg cag ctg gtc ggc att cac atg cac att      576
Val Ile Gln Arg His His Leu Gln Leu Val Gly Ile His Met His Ile         
            180                 185                 190                 

ggt tct ggc gtt gat tat gcc cat ctg gaa cag gtg tgt ggt gct atg      624
Gly Ser Gly Val Asp Tyr Ala His Leu Glu Gln Val Cys Gly Ala Met         
        195                 200                 205                     

gtg cgt cag gtc atc gaa ttc ggt cag gat tta cag gct att tct gcg      672
Val Arg Gln Val Ile Glu Phe Gly Gln Asp Leu Gln Ala Ile Ser Ala         
    210                 215                 220                         

ggc ggt ggg ctt tct gtt cct tat caa cag ggt gaa gag gcg gtt gat      720
Gly Gly Gly Leu Ser Val Pro Tyr Gln Gln Gly Glu Glu Ala Val Asp         
225                 230                 235                 240         

acc gaa cat tat tat ggt ctg tgg aat gcc gcg cgt gag caa atc gcc      768
Thr Glu His Tyr Tyr Gly Leu Trp Asn Ala Ala Arg Glu Gln Ile Ala         
                245                 250                 255             

cgc cat ttg ggc cac cct gtg aaa ctg gaa att gaa ccg ggt cgc ttc      816
Arg His Leu Gly His Pro Val Lys Leu Glu Ile Glu Pro Gly Arg Phe         
            260                 265                 270                 

ctg gta gcg cag tct ggc gta tta att act cag gtg cgg agc gtc aaa      864
Leu Val Ala Gln Ser Gly Val Leu Ile Thr Gln Val Arg Ser Val Lys         
        275                 280                 285                     

caa atg ggg agc cgc cac ttt gtg ctg gtt gat gcc ggg ttc aac gat      912
Gln Met Gly Ser Arg His Phe Val Leu Val Asp Ala Gly Phe Asn Asp         
    290                 295                 300                         

ctg atg cgc ccg gca atg tac ggt agt tac cac cat atc agt gcc ctg      960
Leu Met Arg Pro Ala Met Tyr Gly Ser Tyr His His Ile Ser Ala Leu         
305                 310                 315                 320         

gca gct gat ggt cgt tct ctg gaa cac gcg cca acg gtg gaa acc gtc     1008
Ala Ala Asp Gly Arg Ser Leu Glu His Ala Pro Thr Val Glu Thr Val         
                325                 330                 335             

gtc gcc gga ccg tta tgt gaa tcg ggc gat gtc ttt acc cag cag gaa     1056
Val Ala Gly Pro Leu Cys Glu Ser Gly Asp Val Phe Thr Gln Gln Glu         
            340                 345                 350                 

ggg gga aat gtt gaa acc cgc gcc ttg ccg gaa gtg aag gca ggt gat     1104
Gly Gly Asn Val Glu Thr Arg Ala Leu Pro Glu Val Lys Ala Gly Asp         
        355                 360                 365                     

tat ctg gta ctg cat gat aca ggg gca tat ggc gca tca atg tca tcc     1152
Tyr Leu Val Leu His Asp Thr Gly Ala Tyr Gly Ala Ser Met Ser Ser         
    370                 375                 380                         

aac tac aat agc cgt ccg ctg tta cca gaa gtt ctg ttt gat aat ggt     1200
Asn Tyr Asn Ser Arg Pro Leu Leu Pro Glu Val Leu Phe Asp Asn Gly         
385                 390                 395                 400         

cag gcg cgg ttg att cgc cgt cgc cag acc atc gaa gaa tta ctg gcg     1248
Gln Ala Arg Leu Ile Arg Arg Arg Gln Thr Ile Glu Glu Leu Leu Ala         
                405                 410                 415             

ctg gaa ttg ctt taa                                                 1263
Leu Glu Leu Leu                                                         
            420                                                         


<210>  106
<211>  420
<212>  PRT
<213>  Escherichia coli

<400>  106

Met Pro His Ser Leu Phe Ser Thr Asp Thr Asp Leu Thr Ala Glu Asn 
1               5                   10                  15      


Leu Leu Arg Leu Pro Ala Glu Phe Gly Cys Pro Val Trp Val Tyr Asp 
            20                  25                  30          


Ala Gln Ile Ile Arg Arg Gln Ile Ala Ala Leu Lys Gln Phe Asp Val 
        35                  40                  45              


Val Arg Phe Ala Gln Lys Ala Cys Ser Asn Ile His Ile Leu Arg Leu 
    50                  55                  60                  


Met Arg Glu Gln Gly Val Lys Val Asp Ser Val Ser Leu Gly Glu Ile 
65                  70                  75                  80  


Glu Arg Ala Leu Ala Ala Gly Tyr Asn Pro Gln Thr His Pro Asp Asp 
                85                  90                  95      


Ile Val Phe Thr Ala Asp Val Ile Asp Gln Ala Thr Leu Glu Arg Val 
            100                 105                 110         


Ser Glu Leu Gln Ile Pro Val Asn Ala Gly Ser Val Asp Met Leu Asp 
        115                 120                 125             


Gln Leu Gly Gln Val Ser Pro Gly His Arg Val Trp Leu Arg Val Asn 
    130                 135                 140                 


Pro Gly Phe Gly His Gly His Ser Gln Lys Thr Asn Thr Gly Gly Glu 
145                 150                 155                 160 


Asn Ser Lys His Gly Ile Trp Tyr Thr Asp Leu Pro Ala Ala Leu Asp 
                165                 170                 175     


Val Ile Gln Arg His His Leu Gln Leu Val Gly Ile His Met His Ile 
            180                 185                 190         


Gly Ser Gly Val Asp Tyr Ala His Leu Glu Gln Val Cys Gly Ala Met 
        195                 200                 205             


Val Arg Gln Val Ile Glu Phe Gly Gln Asp Leu Gln Ala Ile Ser Ala 
    210                 215                 220                 


Gly Gly Gly Leu Ser Val Pro Tyr Gln Gln Gly Glu Glu Ala Val Asp 
225                 230                 235                 240 


Thr Glu His Tyr Tyr Gly Leu Trp Asn Ala Ala Arg Glu Gln Ile Ala 
                245                 250                 255     


Arg His Leu Gly His Pro Val Lys Leu Glu Ile Glu Pro Gly Arg Phe 
            260                 265                 270         


Leu Val Ala Gln Ser Gly Val Leu Ile Thr Gln Val Arg Ser Val Lys 
        275                 280                 285             


Gln Met Gly Ser Arg His Phe Val Leu Val Asp Ala Gly Phe Asn Asp 
    290                 295                 300                 


Leu Met Arg Pro Ala Met Tyr Gly Ser Tyr His His Ile Ser Ala Leu 
305                 310                 315                 320 


Ala Ala Asp Gly Arg Ser Leu Glu His Ala Pro Thr Val Glu Thr Val 
                325                 330                 335     


Val Ala Gly Pro Leu Cys Glu Ser Gly Asp Val Phe Thr Gln Gln Glu 
            340                 345                 350         


Gly Gly Asn Val Glu Thr Arg Ala Leu Pro Glu Val Lys Ala Gly Asp 
        355                 360                 365             


Tyr Leu Val Leu His Asp Thr Gly Ala Tyr Gly Ala Ser Met Ser Ser 
    370                 375                 380                 


Asn Tyr Asn Ser Arg Pro Leu Leu Pro Glu Val Leu Phe Asp Asn Gly 
385                 390                 395                 400 


Gln Ala Arg Leu Ile Arg Arg Arg Gln Thr Ile Glu Glu Leu Leu Ala 
                405                 410                 415     


Leu Glu Leu Leu 
            420 


<210>  107
<211>  1265
<212>  DNA
<213>  Artificial

<220>
<223>  Escherichia.coli diaminopimelate decarboxylase LysA codon 
       optimised gene

<400>  107
atatgccaca ctctctgttt tctactgata ctgatctgac tgcggaaaac ctgctgcgtc     60

tgccggctga attcggttgt ccggtatggg tgtacgacgc tcagattatt cgtcgccaga    120

tcgcagcact gaagcagttc gatgtagtgc gttttgcaca gaaggcgtgc tccaacatcc    180

atatcctgcg cctgatgcgt gagcagggcg ttaaagttga ctccgtctct ctgggtgaga    240

ttgagcgcgc cctggcagcc ggctataacc cacagaccca tcctgacgac attgtattta    300

ctgccgacgt gatcgaccag gctactctgg aacgcgtttc tgaactgcag atcccggtta    360

atgctggttc tgtggacatg ctggaccagc tgggccaggt atccccaggt catcgtgtgt    420

ggctgcgtgt caacccaggt ttcggccacg gccactctca gaaaactaac actggtggtg    480

agaactccaa gcatggcatt tggtataccg atctgccggc tgcactggac gtaatccagc    540

gtcaccacct gcagctggtg ggcatccaca tgcacattgg ctccggcgta gactacgccc    600

acctggagca agtctgcggt gctatggtac gtcaggtaat cgagttcggc caagatctgc    660

aggcaatcag cgctggtggc ggcctgtctg taccttatca gcagggcgag gaggcggttg    720

acactgagca ctactacggt ctgtggaacg ccgctcgtga gcaaattgca cgtcacctgg    780

gccacccggt gaaactggag atcgagccgg gccgcttcct ggtagcacag tccggcgtac    840

tgattaccca ggtacgctct gttaaacaga tgggctcccg tcactttgtg ctggtagacg    900

caggcttcaa cgacctgatg cgtccggcta tgtatggttc ctatcatcac atctctgcgc    960

tggccgccga cggccgctct ctggaacacg cgccgacggt tgaaacggtg gtggctggtc   1020

cgctgtgcga gtccggcgac gttttcactc agcaggaggg cggcaatgta gagacgcgtg   1080

cgctgccgga agtgaaagcc ggtgattatc tggtgctgca tgataccggc gcctatggtg   1140

cgagcatgag cagcaactac aactctcgcc cgctgctgcc ggaggtcctg ttcgataacg   1200

gccaagcccg cctgatccgt cgtcgtcaga ccatcgagga actgctggca ctggagctgc   1260

tgtaa                                                               1265


<210>  108
<211>  1692
<212>  DNA
<213>  Saccharomyces cerevisiae


<220>
<221>  CDS
<222>  (1)..(1692)

<400>  108
atg tct gaa att act ttg ggt aaa tat ttg ttc gaa aga tta aag caa       48
Met Ser Glu Ile Thr Leu Gly Lys Tyr Leu Phe Glu Arg Leu Lys Gln         
1               5                   10                  15              

gtc aac gtt aac acc gtt ttc ggt ttg cca ggt gac ttc aac ttg tcc       96
Val Asn Val Asn Thr Val Phe Gly Leu Pro Gly Asp Phe Asn Leu Ser         
            20                  25                  30                  

ttg ttg gac aag atc tac gaa gtt gaa ggt atg aga tgg gct ggt aac      144
Leu Leu Asp Lys Ile Tyr Glu Val Glu Gly Met Arg Trp Ala Gly Asn         
        35                  40                  45                      

gcc aac gaa ttg aac gct gct tac gcc gct gat ggt tac gct cgt atc      192
Ala Asn Glu Leu Asn Ala Ala Tyr Ala Ala Asp Gly Tyr Ala Arg Ile         
    50                  55                  60                          

aag ggt atg tct tgt atc atc acc acc ttc ggt gtc ggt gaa ttg tct      240
Lys Gly Met Ser Cys Ile Ile Thr Thr Phe Gly Val Gly Glu Leu Ser         
65                  70                  75                  80          

gct ttg aac ggt att gcc ggt tct tac gct gaa cac gtc ggt gtt ttg      288
Ala Leu Asn Gly Ile Ala Gly Ser Tyr Ala Glu His Val Gly Val Leu         
                85                  90                  95              

cac gtt gtt ggt gtc cca tcc atc tct gct caa gct aag caa ttg ttg      336
His Val Val Gly Val Pro Ser Ile Ser Ala Gln Ala Lys Gln Leu Leu         
            100                 105                 110                 

ttg cac cac acc ttg ggt aac ggt gac ttc act gtt ttc cac aga atg      384
Leu His His Thr Leu Gly Asn Gly Asp Phe Thr Val Phe His Arg Met         
        115                 120                 125                     

tct gcc aac att tct gaa acc act gct atg atc act gac att gct acc      432
Ser Ala Asn Ile Ser Glu Thr Thr Ala Met Ile Thr Asp Ile Ala Thr         
    130                 135                 140                         

gcc cca gct gaa att gac aga tgt atc aga acc act tac gtc acc caa      480
Ala Pro Ala Glu Ile Asp Arg Cys Ile Arg Thr Thr Tyr Val Thr Gln         
145                 150                 155                 160         

aga cca gtc tac tta ggt ttg cca gct aac ttg gtc gac ttg aac gtc      528
Arg Pro Val Tyr Leu Gly Leu Pro Ala Asn Leu Val Asp Leu Asn Val         
                165                 170                 175             

cca gct aag ttg ttg caa act cca att gac atg tct ttg aag cca aac      576
Pro Ala Lys Leu Leu Gln Thr Pro Ile Asp Met Ser Leu Lys Pro Asn         
            180                 185                 190                 

gat gct gaa tcc gaa aag gaa gtc att gac acc atc ttg gct ttg gtc      624
Asp Ala Glu Ser Glu Lys Glu Val Ile Asp Thr Ile Leu Ala Leu Val         
        195                 200                 205                     

aag gat gct aag aac cca gtt atc ttg gct gat gct tgt tgt tcc aga      672
Lys Asp Ala Lys Asn Pro Val Ile Leu Ala Asp Ala Cys Cys Ser Arg         
    210                 215                 220                         

cac gac gtc aag gct gaa act aag aag ttg att gac ttg act caa ttc      720
His Asp Val Lys Ala Glu Thr Lys Lys Leu Ile Asp Leu Thr Gln Phe         
225                 230                 235                 240         

cca gct ttc gtc acc cca atg ggt aag ggt tcc att gac gaa caa cac      768
Pro Ala Phe Val Thr Pro Met Gly Lys Gly Ser Ile Asp Glu Gln His         
                245                 250                 255             

cca aga tac ggt ggt gtt tac gtc ggt acc ttg tcc aag cca gaa gtt      816
Pro Arg Tyr Gly Gly Val Tyr Val Gly Thr Leu Ser Lys Pro Glu Val         
            260                 265                 270                 

aag gaa gcc gtt gaa tct gct gac ttg att ttg tct gtc ggt gct ttg      864
Lys Glu Ala Val Glu Ser Ala Asp Leu Ile Leu Ser Val Gly Ala Leu         
        275                 280                 285                     

ttg tct gat ttc aac acc ggt tct ttc tct tac tct tac aag acc aag      912
Leu Ser Asp Phe Asn Thr Gly Ser Phe Ser Tyr Ser Tyr Lys Thr Lys         
    290                 295                 300                         

aac att gtc gaa ttc cac tcc gac cac atg aag atc aga aac gcc act      960
Asn Ile Val Glu Phe His Ser Asp His Met Lys Ile Arg Asn Ala Thr         
305                 310                 315                 320         

ttc cca ggt gtc caa atg aaa ttc gtt ttg caa aag ttg ttg acc act     1008
Phe Pro Gly Val Gln Met Lys Phe Val Leu Gln Lys Leu Leu Thr Thr         
                325                 330                 335             

att gct gac gcc gct aag ggt tac aag cca gtt gct gtc cca gct aga     1056
Ile Ala Asp Ala Ala Lys Gly Tyr Lys Pro Val Ala Val Pro Ala Arg         
            340                 345                 350                 

act cca gct aac gct gct gtc cca gct tct acc cca ttg aag caa gaa     1104
Thr Pro Ala Asn Ala Ala Val Pro Ala Ser Thr Pro Leu Lys Gln Glu         
        355                 360                 365                     

tgg atg tgg aac caa ttg ggt aac ttc ttg caa gaa ggt gat gtt gtc     1152
Trp Met Trp Asn Gln Leu Gly Asn Phe Leu Gln Glu Gly Asp Val Val         
    370                 375                 380                         

att gct gaa acc ggt acc tcc gct ttc ggt atc aac caa acc act ttc     1200
Ile Ala Glu Thr Gly Thr Ser Ala Phe Gly Ile Asn Gln Thr Thr Phe         
385                 390                 395                 400         

cca aac aac acc tac ggt atc tct caa gtc tta tgg ggt tcc att ggt     1248
Pro Asn Asn Thr Tyr Gly Ile Ser Gln Val Leu Trp Gly Ser Ile Gly         
                405                 410                 415             

ttc acc act ggt gct acc ttg ggt gct gct ttc gct gct gaa gaa att     1296
Phe Thr Thr Gly Ala Thr Leu Gly Ala Ala Phe Ala Ala Glu Glu Ile         
            420                 425                 430                 

gat cca aag aag aga gtt atc tta ttc att ggt gac ggt tct ttg caa     1344
Asp Pro Lys Lys Arg Val Ile Leu Phe Ile Gly Asp Gly Ser Leu Gln         
        435                 440                 445                     

ttg act gtt caa gaa atc tcc acc atg atc aga tgg ggc ttg aag cca     1392
Leu Thr Val Gln Glu Ile Ser Thr Met Ile Arg Trp Gly Leu Lys Pro         
    450                 455                 460                         

tac ttg ttc gtc ttg aac aac gat ggt tac acc att gaa aag ttg att     1440
Tyr Leu Phe Val Leu Asn Asn Asp Gly Tyr Thr Ile Glu Lys Leu Ile         
465                 470                 475                 480         

cac ggt cca aag gct caa tac aac gaa att caa ggt tgg gac cac cta     1488
His Gly Pro Lys Ala Gln Tyr Asn Glu Ile Gln Gly Trp Asp His Leu         
                485                 490                 495             

tcc ttg ttg cca act ttc ggt gct aag gac tat gaa acc cac aga gtc     1536
Ser Leu Leu Pro Thr Phe Gly Ala Lys Asp Tyr Glu Thr His Arg Val         
            500                 505                 510                 

gct acc acc ggt gaa tgg gac aag ttg acc caa gac aag tct ttc aac     1584
Ala Thr Thr Gly Glu Trp Asp Lys Leu Thr Gln Asp Lys Ser Phe Asn         
        515                 520                 525                     

gac aac tct aag atc aga atg att gaa atc atg ttg cca gtc ttc gat     1632
Asp Asn Ser Lys Ile Arg Met Ile Glu Ile Met Leu Pro Val Phe Asp         
    530                 535                 540                         

gct cca caa aac ttg gtt gaa caa gct aag ttg act gct gct acc aac     1680
Ala Pro Gln Asn Leu Val Glu Gln Ala Lys Leu Thr Ala Ala Thr Asn         
545                 550                 555                 560         

gct aag caa taa                                                     1692
Ala Lys Gln                                                             
                                                                        


<210>  109
<211>  563
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  109

Met Ser Glu Ile Thr Leu Gly Lys Tyr Leu Phe Glu Arg Leu Lys Gln 
1               5                   10                  15      


Val Asn Val Asn Thr Val Phe Gly Leu Pro Gly Asp Phe Asn Leu Ser 
            20                  25                  30          


Leu Leu Asp Lys Ile Tyr Glu Val Glu Gly Met Arg Trp Ala Gly Asn 
        35                  40                  45              


Ala Asn Glu Leu Asn Ala Ala Tyr Ala Ala Asp Gly Tyr Ala Arg Ile 
    50                  55                  60                  


Lys Gly Met Ser Cys Ile Ile Thr Thr Phe Gly Val Gly Glu Leu Ser 
65                  70                  75                  80  


Ala Leu Asn Gly Ile Ala Gly Ser Tyr Ala Glu His Val Gly Val Leu 
                85                  90                  95      


His Val Val Gly Val Pro Ser Ile Ser Ala Gln Ala Lys Gln Leu Leu 
            100                 105                 110         


Leu His His Thr Leu Gly Asn Gly Asp Phe Thr Val Phe His Arg Met 
        115                 120                 125             


Ser Ala Asn Ile Ser Glu Thr Thr Ala Met Ile Thr Asp Ile Ala Thr 
    130                 135                 140                 


Ala Pro Ala Glu Ile Asp Arg Cys Ile Arg Thr Thr Tyr Val Thr Gln 
145                 150                 155                 160 


Arg Pro Val Tyr Leu Gly Leu Pro Ala Asn Leu Val Asp Leu Asn Val 
                165                 170                 175     


Pro Ala Lys Leu Leu Gln Thr Pro Ile Asp Met Ser Leu Lys Pro Asn 
            180                 185                 190         


Asp Ala Glu Ser Glu Lys Glu Val Ile Asp Thr Ile Leu Ala Leu Val 
        195                 200                 205             


Lys Asp Ala Lys Asn Pro Val Ile Leu Ala Asp Ala Cys Cys Ser Arg 
    210                 215                 220                 


His Asp Val Lys Ala Glu Thr Lys Lys Leu Ile Asp Leu Thr Gln Phe 
225                 230                 235                 240 


Pro Ala Phe Val Thr Pro Met Gly Lys Gly Ser Ile Asp Glu Gln His 
                245                 250                 255     


Pro Arg Tyr Gly Gly Val Tyr Val Gly Thr Leu Ser Lys Pro Glu Val 
            260                 265                 270         


Lys Glu Ala Val Glu Ser Ala Asp Leu Ile Leu Ser Val Gly Ala Leu 
        275                 280                 285             


Leu Ser Asp Phe Asn Thr Gly Ser Phe Ser Tyr Ser Tyr Lys Thr Lys 
    290                 295                 300                 


Asn Ile Val Glu Phe His Ser Asp His Met Lys Ile Arg Asn Ala Thr 
305                 310                 315                 320 


Phe Pro Gly Val Gln Met Lys Phe Val Leu Gln Lys Leu Leu Thr Thr 
                325                 330                 335     


Ile Ala Asp Ala Ala Lys Gly Tyr Lys Pro Val Ala Val Pro Ala Arg 
            340                 345                 350         


Thr Pro Ala Asn Ala Ala Val Pro Ala Ser Thr Pro Leu Lys Gln Glu 
        355                 360                 365             


Trp Met Trp Asn Gln Leu Gly Asn Phe Leu Gln Glu Gly Asp Val Val 
    370                 375                 380                 


Ile Ala Glu Thr Gly Thr Ser Ala Phe Gly Ile Asn Gln Thr Thr Phe 
385                 390                 395                 400 


Pro Asn Asn Thr Tyr Gly Ile Ser Gln Val Leu Trp Gly Ser Ile Gly 
                405                 410                 415     


Phe Thr Thr Gly Ala Thr Leu Gly Ala Ala Phe Ala Ala Glu Glu Ile 
            420                 425                 430         


Asp Pro Lys Lys Arg Val Ile Leu Phe Ile Gly Asp Gly Ser Leu Gln 
        435                 440                 445             


Leu Thr Val Gln Glu Ile Ser Thr Met Ile Arg Trp Gly Leu Lys Pro 
    450                 455                 460                 


Tyr Leu Phe Val Leu Asn Asn Asp Gly Tyr Thr Ile Glu Lys Leu Ile 
465                 470                 475                 480 


His Gly Pro Lys Ala Gln Tyr Asn Glu Ile Gln Gly Trp Asp His Leu 
                485                 490                 495     


Ser Leu Leu Pro Thr Phe Gly Ala Lys Asp Tyr Glu Thr His Arg Val 
            500                 505                 510         


Ala Thr Thr Gly Glu Trp Asp Lys Leu Thr Gln Asp Lys Ser Phe Asn 
        515                 520                 525             


Asp Asn Ser Lys Ile Arg Met Ile Glu Ile Met Leu Pro Val Phe Asp 
    530                 535                 540                 


Ala Pro Gln Asn Leu Val Glu Gln Ala Lys Leu Thr Ala Ala Thr Asn 
545                 550                 555                 560 


Ala Lys Gln 
            


<210>  110
<211>  1692
<212>  DNA
<213>  Artificial

<220>
<223>  Saccharomyces cerevisiae pyruvate decarboxylase Pdc codon 
       optimised gene

<400>  110
atgtccgaga tcactctggg caaatacctg tttgaacgtc tgaaacaggt gaacgttaat     60

accgtattcg gcctgccggg tgatttcaac ctgtccctgc tggacaaaat ctatgaagtt    120

gaaggtatgc gttgggctgg caacgctaac gagctgaacg cagcgtacgc ggcagatggt    180

tacgctcgta tcaaaggtat gtcttgtatc atcaccacct tcggtgttgg tgagctgagc    240

gccctgaacg gcatcgccgg ctcctatgca gagcacgtgg gcgtgctgca cgttgtgggt    300

gtaccgtcca tcagcgccca ggcaaaacag ctgctgctgc accacaccct gggtaacggc    360

gactttaccg ttttccatcg tatgtctgcg aacatcagcg aaactactgc aatgattact    420

gacatcgcta cggcaccggc agaaatcgac cgttgcattc gtaccacgta cgttactcag    480

cgcccggttt atctgggcct gccagccaac ctggtggatc tgaacgtccc ggctaaactg    540

ctgcagactc cgatcgatat gtctctgaaa cctaacgacg cagaatctga gaaagaagtt    600

atcgatacta ttctggctct ggtgaaagat gcaaagaacc cagttatcct ggctgacgca    660

tgttgctctc gtcatgatgt aaaggcagaa accaaaaagc tgatcgacct gacgcagttc    720

ccggcgttcg ttaccccgat gggcaagggt tccatcgatg agcagcaccc gcgttatggt    780

ggtgtatacg ttggcacgct gtccaaaccg gaggtaaaag aagcggttga aagcgcagat    840

ctgatcctgt ctgttggtgc actgctgagc gacttcaaca ccggttcttt ctcctatagc    900

tacaagacca aaaacattgt ggagtttcac tccgatcaca tgaaaatccg caacgcgacc    960

tttcctggtg tgcagatgaa attcgtactg cagaaactgc tgaccaccat cgccgacgct   1020

gcgaaaggtt ataaaccggt agctgtgccg gcacgtaccc cggcgaacgc cgcggttcct   1080

gcatccactc cactgaagca ggaatggatg tggaatcagc tgggtaattt cctgcaagaa   1140

ggcgacgttg taatcgcaga aaccggcact agcgcgtttg gcattaacca gacgaccttc   1200

ccaaacaaca cctacggtat cagccaagtc ctgtggggct ctatcggctt caccaccggt   1260

gcaaccctgg gtgcggcttt cgctgctgag gagatcgacc cgaagaaacg tgttatcctg   1320

ttcatcggtg acggctccct gcagctgacc gtccaggaga tttctaccat gatccgctgg   1380

ggcctgaaac cgtacctgtt tgtgctgaac aacgacggct acactattga gaaactgatc   1440

cacggtccga aagcacagta taatgagatc cagggttggg atcatctgtc tctgctgccg   1500

acctttggcg ctaaagacta cgagacccac cgcgtggcta ccaccggcga gtgggataaa   1560

ctgacgcagg ataaatcctt caatgacaat agcaagattc gtatgatcga aatcatgctg   1620

ccggtctttg atgctccgca gaacctggta gagcaagcaa aactgaccgc ggcaactaac   1680

gctaaacagt aa                                                       1692


<210>  111
<211>  1707
<212>  DNA
<213>  Zymomonas mobilis


<220>
<221>  CDS
<222>  (1)..(1707)

<400>  111
atg agt tat act gtc ggt acc tat tta gcg gag cgg ctt gtc cag att       48
Met Ser Tyr Thr Val Gly Thr Tyr Leu Ala Glu Arg Leu Val Gln Ile         
1               5                   10                  15              

ggt ctc aag cat cac ttc gca gtc gcg ggc gac tac aac ctc gtc ctt       96
Gly Leu Lys His His Phe Ala Val Ala Gly Asp Tyr Asn Leu Val Leu         
            20                  25                  30                  

ctt gac aac ctg ctt ttg aac aaa aac atg gag cag gtt tat tgc tgt      144
Leu Asp Asn Leu Leu Leu Asn Lys Asn Met Glu Gln Val Tyr Cys Cys         
        35                  40                  45                      

aac gaa ctg aac tgc ggt ttc agt gca gaa ggt tat gct cgt gcc aaa      192
Asn Glu Leu Asn Cys Gly Phe Ser Ala Glu Gly Tyr Ala Arg Ala Lys         
    50                  55                  60                          

ggc gca gca gca gcc gtc gtt acc tac agc gtc ggt gcg ctt tcc gca      240
Gly Ala Ala Ala Ala Val Val Thr Tyr Ser Val Gly Ala Leu Ser Ala         
65                  70                  75                  80          

ttt gat gct atc ggt ggc gcc tat gca gaa aac ctt ccg gtt atc ctg      288
Phe Asp Ala Ile Gly Gly Ala Tyr Ala Glu Asn Leu Pro Val Ile Leu         
                85                  90                  95              

atc tcc ggt gct ccg aac aac aat gat cac gct gct ggt cac gtg ttg      336
Ile Ser Gly Ala Pro Asn Asn Asn Asp His Ala Ala Gly His Val Leu         
            100                 105                 110                 

cat cac gct ctt ggc aaa acc gac tat cac tat cag ttg gaa atg gcc      384
His His Ala Leu Gly Lys Thr Asp Tyr His Tyr Gln Leu Glu Met Ala         
        115                 120                 125                     

aag aac atc acg gcc gcc gct gaa gcg att tac acc ccg gaa gaa gct      432
Lys Asn Ile Thr Ala Ala Ala Glu Ala Ile Tyr Thr Pro Glu Glu Ala         
    130                 135                 140                         

ccg gct aaa atc gat cac gtg att aaa act gct ctt cgt gag aag aag      480
Pro Ala Lys Ile Asp His Val Ile Lys Thr Ala Leu Arg Glu Lys Lys         
145                 150                 155                 160         

ccg gtt tat ctc gaa atc gct tgc aac att gct tcc atg ccc tgc gcc      528
Pro Val Tyr Leu Glu Ile Ala Cys Asn Ile Ala Ser Met Pro Cys Ala         
                165                 170                 175             

gct cct gga ccg gca agc gca ttg ttc aat gac gaa gcc agc gac gaa      576
Ala Pro Gly Pro Ala Ser Ala Leu Phe Asn Asp Glu Ala Ser Asp Glu         
            180                 185                 190                 

gct tct ttg aat gca gcg gtt gaa gaa acc ctg aaa ttc atc gcc aac      624
Ala Ser Leu Asn Ala Ala Val Glu Glu Thr Leu Lys Phe Ile Ala Asn         
        195                 200                 205                     

cgc gac aaa gtt gcc gtc ctc gtc ggc agc aag ctg cgc gca gct ggt      672
Arg Asp Lys Val Ala Val Leu Val Gly Ser Lys Leu Arg Ala Ala Gly         
    210                 215                 220                         

gct gaa gaa gct gct gtc aaa ttt gct gat gct ctc ggt ggc gca gtt      720
Ala Glu Glu Ala Ala Val Lys Phe Ala Asp Ala Leu Gly Gly Ala Val         
225                 230                 235                 240         

gct acc atg gct gct gca aaa agc ttc ttc cca gaa gaa aac ccg cat      768
Ala Thr Met Ala Ala Ala Lys Ser Phe Phe Pro Glu Glu Asn Pro His         
                245                 250                 255             

tac atc ggc acc tca tgg ggt gaa gtc agc tat ccg ggc gtt gaa aag      816
Tyr Ile Gly Thr Ser Trp Gly Glu Val Ser Tyr Pro Gly Val Glu Lys         
            260                 265                 270                 

acg atg aaa gaa gcc gat gcg gtt atc gct ctg gct cct gtc ttc aac      864
Thr Met Lys Glu Ala Asp Ala Val Ile Ala Leu Ala Pro Val Phe Asn         
        275                 280                 285                     

gac tac tcc acc act ggt tgg acg gat att cct gat cct aag aaa ctg      912
Asp Tyr Ser Thr Thr Gly Trp Thr Asp Ile Pro Asp Pro Lys Lys Leu         
    290                 295                 300                         

gtt ctc gct gaa ccg cgt tct gtc gtc gtt aac ggc att cgc ttc ccc      960
Val Leu Ala Glu Pro Arg Ser Val Val Val Asn Gly Ile Arg Phe Pro         
305                 310                 315                 320         

agc gtc cat ctg aaa gac tat ctg acc cgt ttg gct cag aaa gtt tcc     1008
Ser Val His Leu Lys Asp Tyr Leu Thr Arg Leu Ala Gln Lys Val Ser         
                325                 330                 335             

aag aaa acc ggt gca ttg gac ttc ttc aaa tcc ctc aat gca ggt gaa     1056
Lys Lys Thr Gly Ala Leu Asp Phe Phe Lys Ser Leu Asn Ala Gly Glu         
            340                 345                 350                 

ctg aag aaa gcc gct ccg gct gat ccg agt gct ccg ttg gtc aac gca     1104
Leu Lys Lys Ala Ala Pro Ala Asp Pro Ser Ala Pro Leu Val Asn Ala         
        355                 360                 365                     

gaa atc gcc cgt cag gtc gaa gct ctt ctg acc ccg aac acg acg gtt     1152
Glu Ile Ala Arg Gln Val Glu Ala Leu Leu Thr Pro Asn Thr Thr Val         
    370                 375                 380                         

att gct gaa acc ggt gac tct tgg ttc aat gct cag cgc atg aag ctc     1200
Ile Ala Glu Thr Gly Asp Ser Trp Phe Asn Ala Gln Arg Met Lys Leu         
385                 390                 395                 400         

ccg aac ggt gct cgc gtt gaa tat gaa atg cag tgg ggt cac att ggt     1248
Pro Asn Gly Ala Arg Val Glu Tyr Glu Met Gln Trp Gly His Ile Gly         
                405                 410                 415             

tgg tcc gtt cct gcc gcc ttc ggt tat gcc gtc ggt gct ccg gaa cgt     1296
Trp Ser Val Pro Ala Ala Phe Gly Tyr Ala Val Gly Ala Pro Glu Arg         
            420                 425                 430                 

cgc aac atc ctc atg gtt ggt gat ggt tcc ttc cag ctg acg gct cag     1344
Arg Asn Ile Leu Met Val Gly Asp Gly Ser Phe Gln Leu Thr Ala Gln         
        435                 440                 445                     

gaa gtc gct cag atg gtt cgc ctg aaa ctg ccg gtt atc atc ttc ttg     1392
Glu Val Ala Gln Met Val Arg Leu Lys Leu Pro Val Ile Ile Phe Leu         
    450                 455                 460                         

atc aat aac tat ggt tac acc gcc gaa gtt atg atc cat gat ggt ccg     1440
Ile Asn Asn Tyr Gly Tyr Thr Ala Glu Val Met Ile His Asp Gly Pro         
465                 470                 475                 480         

tac aac aac atc aag aac tgg gat tat gcc ggt ctg atg gaa gtg ttc     1488
Tyr Asn Asn Ile Lys Asn Trp Asp Tyr Ala Gly Leu Met Glu Val Phe         
                485                 490                 495             

aac ggt aac ggt ggt tat gac agc ggt gct ggt aaa ggc ctg aag gct     1536
Asn Gly Asn Gly Gly Tyr Asp Ser Gly Ala Gly Lys Gly Leu Lys Ala         
            500                 505                 510                 

aaa acc ggt ggc gaa ctg gca gaa gct atc aag gtt gct ctg gca aac     1584
Lys Thr Gly Gly Glu Leu Ala Glu Ala Ile Lys Val Ala Leu Ala Asn         
        515                 520                 525                     

acc gac ggc cca acc ctg atc gaa tgc ttc atc ggt cgt gaa gac tgc     1632
Thr Asp Gly Pro Thr Leu Ile Glu Cys Phe Ile Gly Arg Glu Asp Cys         
    530                 535                 540                         

act gaa gaa ttg gtc aaa tgg ggt aag cgc gtt gct gcc gcc aac agc     1680
Thr Glu Glu Leu Val Lys Trp Gly Lys Arg Val Ala Ala Ala Asn Ser         
545                 550                 555                 560         

cgt aag cct gtt aac aag ctc ctc tag                                 1707
Arg Lys Pro Val Asn Lys Leu Leu                                         
                565                                                     


<210>  112
<211>  568
<212>  PRT
<213>  Zymomonas mobilis

<400>  112

Met Ser Tyr Thr Val Gly Thr Tyr Leu Ala Glu Arg Leu Val Gln Ile 
1               5                   10                  15      


Gly Leu Lys His His Phe Ala Val Ala Gly Asp Tyr Asn Leu Val Leu 
            20                  25                  30          


Leu Asp Asn Leu Leu Leu Asn Lys Asn Met Glu Gln Val Tyr Cys Cys 
        35                  40                  45              


Asn Glu Leu Asn Cys Gly Phe Ser Ala Glu Gly Tyr Ala Arg Ala Lys 
    50                  55                  60                  


Gly Ala Ala Ala Ala Val Val Thr Tyr Ser Val Gly Ala Leu Ser Ala 
65                  70                  75                  80  


Phe Asp Ala Ile Gly Gly Ala Tyr Ala Glu Asn Leu Pro Val Ile Leu 
                85                  90                  95      


Ile Ser Gly Ala Pro Asn Asn Asn Asp His Ala Ala Gly His Val Leu 
            100                 105                 110         


His His Ala Leu Gly Lys Thr Asp Tyr His Tyr Gln Leu Glu Met Ala 
        115                 120                 125             


Lys Asn Ile Thr Ala Ala Ala Glu Ala Ile Tyr Thr Pro Glu Glu Ala 
    130                 135                 140                 


Pro Ala Lys Ile Asp His Val Ile Lys Thr Ala Leu Arg Glu Lys Lys 
145                 150                 155                 160 


Pro Val Tyr Leu Glu Ile Ala Cys Asn Ile Ala Ser Met Pro Cys Ala 
                165                 170                 175     


Ala Pro Gly Pro Ala Ser Ala Leu Phe Asn Asp Glu Ala Ser Asp Glu 
            180                 185                 190         


Ala Ser Leu Asn Ala Ala Val Glu Glu Thr Leu Lys Phe Ile Ala Asn 
        195                 200                 205             


Arg Asp Lys Val Ala Val Leu Val Gly Ser Lys Leu Arg Ala Ala Gly 
    210                 215                 220                 


Ala Glu Glu Ala Ala Val Lys Phe Ala Asp Ala Leu Gly Gly Ala Val 
225                 230                 235                 240 


Ala Thr Met Ala Ala Ala Lys Ser Phe Phe Pro Glu Glu Asn Pro His 
                245                 250                 255     


Tyr Ile Gly Thr Ser Trp Gly Glu Val Ser Tyr Pro Gly Val Glu Lys 
            260                 265                 270         


Thr Met Lys Glu Ala Asp Ala Val Ile Ala Leu Ala Pro Val Phe Asn 
        275                 280                 285             


Asp Tyr Ser Thr Thr Gly Trp Thr Asp Ile Pro Asp Pro Lys Lys Leu 
    290                 295                 300                 


Val Leu Ala Glu Pro Arg Ser Val Val Val Asn Gly Ile Arg Phe Pro 
305                 310                 315                 320 


Ser Val His Leu Lys Asp Tyr Leu Thr Arg Leu Ala Gln Lys Val Ser 
                325                 330                 335     


Lys Lys Thr Gly Ala Leu Asp Phe Phe Lys Ser Leu Asn Ala Gly Glu 
            340                 345                 350         


Leu Lys Lys Ala Ala Pro Ala Asp Pro Ser Ala Pro Leu Val Asn Ala 
        355                 360                 365             


Glu Ile Ala Arg Gln Val Glu Ala Leu Leu Thr Pro Asn Thr Thr Val 
    370                 375                 380                 


Ile Ala Glu Thr Gly Asp Ser Trp Phe Asn Ala Gln Arg Met Lys Leu 
385                 390                 395                 400 


Pro Asn Gly Ala Arg Val Glu Tyr Glu Met Gln Trp Gly His Ile Gly 
                405                 410                 415     


Trp Ser Val Pro Ala Ala Phe Gly Tyr Ala Val Gly Ala Pro Glu Arg 
            420                 425                 430         


Arg Asn Ile Leu Met Val Gly Asp Gly Ser Phe Gln Leu Thr Ala Gln 
        435                 440                 445             


Glu Val Ala Gln Met Val Arg Leu Lys Leu Pro Val Ile Ile Phe Leu 
    450                 455                 460                 


Ile Asn Asn Tyr Gly Tyr Thr Ala Glu Val Met Ile His Asp Gly Pro 
465                 470                 475                 480 


Tyr Asn Asn Ile Lys Asn Trp Asp Tyr Ala Gly Leu Met Glu Val Phe 
                485                 490                 495     


Asn Gly Asn Gly Gly Tyr Asp Ser Gly Ala Gly Lys Gly Leu Lys Ala 
            500                 505                 510         


Lys Thr Gly Gly Glu Leu Ala Glu Ala Ile Lys Val Ala Leu Ala Asn 
        515                 520                 525             


Thr Asp Gly Pro Thr Leu Ile Glu Cys Phe Ile Gly Arg Glu Asp Cys 
    530                 535                 540                 


Thr Glu Glu Leu Val Lys Trp Gly Lys Arg Val Ala Ala Ala Asn Ser 
545                 550                 555                 560 


Arg Lys Pro Val Asn Lys Leu Leu 
                565             


<210>  113
<211>  1707
<212>  DNA
<213>  Artificial

<220>
<223>  Zymomonas mobilis pyruvate decarboxylase PdcI472A codon optimised
       gene

<400>  113
atgtcttata ctgttggtac ttatctggct gagcgtctgg tgcaaatcgg cctgaaacac     60

cactttgcag ttgctggcga ctacaacctg gttctgctgg ataacctgct gctgaacaaa    120

aacatggagc aagtttattg ctgtaacgag ctgaactgcg gcttctctgc ggagggttat    180

gcgcgtgcga aaggtgccgc tgcagcagtc gtaacctact ctgtgggcgc tctgtccgcg    240

ttcgacgcaa tcggtggcgc ttacgctgaa aacctgccgg tgatcctgat tagcggtgcg    300

ccgaataata acgaccatgc tgctggccac gttctgcacc acgccctggg taaaactgat    360

taccattacc agctggagat ggctaaaaac atcactgcag cagcagaagc gatctacacc    420

ccggaagagg ctccggcaaa aatcgaccac gtgattaaaa ccgctctgcg tgagaaaaag    480

ccggtatacc tggaaatcgc gtgcaacatc gcgtctatgc cgtgcgccgc accgggtccg    540

gcttctgccc tgttcaacga tgaggcgagc gatgaggcat ctctgaacgc agcagtagaa    600

gaaaccctga aatttatcgc aaaccgtgac aaagtagcag tcctggtagg ttctaaactg    660

cgtgcggctg gtgcggaaga ggctgcggta aagttcgcgg atgctctggg cggtgcagtg    720

gcgaccatgg cagcggctaa atccttcttc ccagaggaga acccgcatta cattggtacc    780

tcctggggcg aagtttccta ccctggtgtg gagaaaacca tgaaagaagc cgatgctgtg    840

attgccctgg cgcctgtatt caacgattat tccaccaccg gttggaccga tatcccggac    900

ccgaagaaac tggtcctggc tgaaccgcgc tccgtagtag tgaatggcat tcgtttcccg    960

tccgtacacc tgaaggatta cctgacgcgt ctggcacaga aagtatccaa gaaaactggc   1020

gcgctggact tctttaaatc cctgaacgct ggtgagctga aaaaggcggc tccggccgat   1080

ccgtccgcac cgctggtgaa cgcagagatt gcacgtcagg ttgaggcact gctgacgccg   1140

aacaccaccg taatcgcgga aacgggcgac tcttggttca acgcacagcg catgaaactg   1200

ccgaacggtg cccgcgttga atatgaaatg cagtggggtc acatcggctg gtctgtccca   1260

gcagcgtttg gttacgcggt tggtgcaccg gagcgtcgca acatcctgat ggtgggtgac   1320

ggctccttcc agctgactgc tcaggaggtg gcgcagatgg tgcgcctgaa gctgccggtt   1380

atcattttcc tgatcaacaa ctacggctac accgccgagg taatgatcca cgatggtccg   1440

tacaacaaca tcaaaaactg ggactacgcc ggtctgatgg aggtttttaa cggtaacggc   1500

ggttacgaca gcggtgctgg taagggtctg aaagccaaaa ccggtggcga actggcagag   1560

gcgattaaag ttgcgctggc aaacaccgat ggcccgaccc tgatcgagtg cttcatcggc   1620

cgtgaggact gcaccgagga gctggtcaaa tggggcaaac gtgtggcggc tgctaactct   1680

cgcaagccgg taaacaaact gctgtaa                                       1707


<210>  114
<211>  1644
<212>  DNA
<213>  Lactococcus lactis


<220>
<221>  CDS
<222>  (1)..(1644)

<400>  114
atg tat aca gta gga gat tac ctg tta gac cga tta cac gag ttg gga       48
Met Tyr Thr Val Gly Asp Tyr Leu Leu Asp Arg Leu His Glu Leu Gly         
1               5                   10                  15              

att gaa gaa att ttt gga gtt cct ggt gac tat aac tta caa ttt tta       96
Ile Glu Glu Ile Phe Gly Val Pro Gly Asp Tyr Asn Leu Gln Phe Leu         
            20                  25                  30                  

gat caa att att tca cgc gaa gat atg aaa tgg att gga aat gct aat      144
Asp Gln Ile Ile Ser Arg Glu Asp Met Lys Trp Ile Gly Asn Ala Asn         
        35                  40                  45                      

gaa tta aat gct tct tat atg gct gat ggt tat gct cgt act aaa aaa      192
Glu Leu Asn Ala Ser Tyr Met Ala Asp Gly Tyr Ala Arg Thr Lys Lys         
    50                  55                  60                          

gct gcc gca ttt ctc acc aca ttt gga gtc ggc gaa ttg agt gcg atc      240
Ala Ala Ala Phe Leu Thr Thr Phe Gly Val Gly Glu Leu Ser Ala Ile         
65                  70                  75                  80          

aat gga ctg gca gga agt tat gcc gaa aat tta cca gta gta gaa att      288
Asn Gly Leu Ala Gly Ser Tyr Ala Glu Asn Leu Pro Val Val Glu Ile         
                85                  90                  95              

gtt ggt tca cca act tca aaa gta caa aat gac gga aaa ttt gtc cat      336
Val Gly Ser Pro Thr Ser Lys Val Gln Asn Asp Gly Lys Phe Val His         
            100                 105                 110                 

cat aca cta gca gat ggt gat ttt aaa cac ttt atg aag atg cat gaa      384
His Thr Leu Ala Asp Gly Asp Phe Lys His Phe Met Lys Met His Glu         
        115                 120                 125                     

cct gtt aca gca gcg cgg act tta ctg aca gca gaa aat gcc aca tat      432
Pro Val Thr Ala Ala Arg Thr Leu Leu Thr Ala Glu Asn Ala Thr Tyr         
    130                 135                 140                         

gaa att gac cga gta ctt tct caa tta cta aaa gaa aga aaa cca gtc      480
Glu Ile Asp Arg Val Leu Ser Gln Leu Leu Lys Glu Arg Lys Pro Val         
145                 150                 155                 160         

tat att aac tta cca gtc gat gtt gct gca gca aaa gca gag aag cct      528
Tyr Ile Asn Leu Pro Val Asp Val Ala Ala Ala Lys Ala Glu Lys Pro         
                165                 170                 175             

gca tta tct tta gaa aaa gaa agc tct aca aca aat aca act gaa caa      576
Ala Leu Ser Leu Glu Lys Glu Ser Ser Thr Thr Asn Thr Thr Glu Gln         
            180                 185                 190                 

gtg att ttg agt aag att gaa gaa agt ttg aaa aat gcc caa aaa cca      624
Val Ile Leu Ser Lys Ile Glu Glu Ser Leu Lys Asn Ala Gln Lys Pro         
        195                 200                 205                     

gta gtg att gca gga cac gaa gta att agt ttt ggt tta gaa aaa acg      672
Val Val Ile Ala Gly His Glu Val Ile Ser Phe Gly Leu Glu Lys Thr         
    210                 215                 220                         

gta act cag ttt gtt tca gaa aca aaa cta ccg att acg aca cta aat      720
Val Thr Gln Phe Val Ser Glu Thr Lys Leu Pro Ile Thr Thr Leu Asn         
225                 230                 235                 240         

ttt ggt aaa agt gct gtt gat gaa tct ttg ccc tca ttt tta gga ata      768
Phe Gly Lys Ser Ala Val Asp Glu Ser Leu Pro Ser Phe Leu Gly Ile         
                245                 250                 255             

tat aac ggg aaa ctt tca gaa atc agt ctt aaa aat ttt gtg gag tcc      816
Tyr Asn Gly Lys Leu Ser Glu Ile Ser Leu Lys Asn Phe Val Glu Ser         
            260                 265                 270                 

gca gac ttt atc cta atg ctt gga gtg aag ctt acg gac tcc tca aca      864
Ala Asp Phe Ile Leu Met Leu Gly Val Lys Leu Thr Asp Ser Ser Thr         
        275                 280                 285                     

ggt gca ttc aca cat cat tta gat gaa aat aaa atg att tca cta aac      912
Gly Ala Phe Thr His His Leu Asp Glu Asn Lys Met Ile Ser Leu Asn         
    290                 295                 300                         

ata gat gaa gga ata att ttc aat aaa gtg gta gaa gat ttt gat ttt      960
Ile Asp Glu Gly Ile Ile Phe Asn Lys Val Val Glu Asp Phe Asp Phe         
305                 310                 315                 320         

aga gca gtg gtt tct tct tta tca gaa tta aaa gga ata gaa tat gaa     1008
Arg Ala Val Val Ser Ser Leu Ser Glu Leu Lys Gly Ile Glu Tyr Glu         
                325                 330                 335             

gga caa tat att gat aag caa tat gaa gaa ttt att cca tca agt gct     1056
Gly Gln Tyr Ile Asp Lys Gln Tyr Glu Glu Phe Ile Pro Ser Ser Ala         
            340                 345                 350                 

ccc tta tca caa gac cgt cta tgg cag gca gtt gaa agt ttg act caa     1104
Pro Leu Ser Gln Asp Arg Leu Trp Gln Ala Val Glu Ser Leu Thr Gln         
        355                 360                 365                     

agc aat gaa aca atc gtt gct gaa caa gga acc tca ttt ttt gga gct     1152
Ser Asn Glu Thr Ile Val Ala Glu Gln Gly Thr Ser Phe Phe Gly Ala         
    370                 375                 380                         

tca aca att ttc tta aaa tca aat agt cgt ttt att gga caa cct tta     1200
Ser Thr Ile Phe Leu Lys Ser Asn Ser Arg Phe Ile Gly Gln Pro Leu         
385                 390                 395                 400         

tgg ggt tct att gga tat act ttt cca gcg gct tta gga agc caa att     1248
Trp Gly Ser Ile Gly Tyr Thr Phe Pro Ala Ala Leu Gly Ser Gln Ile         
                405                 410                 415             

gcg gat aaa gag agc aga cac ctt tta ttt att ggt gat ggt tca ctt     1296
Ala Asp Lys Glu Ser Arg His Leu Leu Phe Ile Gly Asp Gly Ser Leu         
            420                 425                 430                 

caa ctt acc gta caa gaa tta gga cta tca atc aga gaa aaa ctc aat     1344
Gln Leu Thr Val Gln Glu Leu Gly Leu Ser Ile Arg Glu Lys Leu Asn         
        435                 440                 445                     

cca att tgt ttt atc ata aat aat gat ggt tat aca gtt gaa aga gaa     1392
Pro Ile Cys Phe Ile Ile Asn Asn Asp Gly Tyr Thr Val Glu Arg Glu         
    450                 455                 460                         

atc cac gga cct act caa agt tat aac gac att cca atg tgg aat tac     1440
Ile His Gly Pro Thr Gln Ser Tyr Asn Asp Ile Pro Met Trp Asn Tyr         
465                 470                 475                 480         

tcg aaa tta cca gaa aca ttt gga gca aca gaa gat cgt gta gta tca     1488
Ser Lys Leu Pro Glu Thr Phe Gly Ala Thr Glu Asp Arg Val Val Ser         
                485                 490                 495             

aaa att gtt aga aca gag aat gaa ttt gtg tct gtc atg aaa gaa gcc     1536
Lys Ile Val Arg Thr Glu Asn Glu Phe Val Ser Val Met Lys Glu Ala         
            500                 505                 510                 

caa gca gat gtc aat aga atg tat tgg ata gaa cta gtt ttg gaa aaa     1584
Gln Ala Asp Val Asn Arg Met Tyr Trp Ile Glu Leu Val Leu Glu Lys         
        515                 520                 525                     

gaa gat gcg cca aaa tta ctg aaa aaa atg ggt aaa tta ttt gct gag     1632
Glu Asp Ala Pro Lys Leu Leu Lys Lys Met Gly Lys Leu Phe Ala Glu         
    530                 535                 540                         

caa aat aaa tag                                                     1644
Gln Asn Lys                                                             
545                                                                     


<210>  115
<211>  547
<212>  PRT
<213>  Lactococcus lactis

<400>  115

Met Tyr Thr Val Gly Asp Tyr Leu Leu Asp Arg Leu His Glu Leu Gly 
1               5                   10                  15      


Ile Glu Glu Ile Phe Gly Val Pro Gly Asp Tyr Asn Leu Gln Phe Leu 
            20                  25                  30          


Asp Gln Ile Ile Ser Arg Glu Asp Met Lys Trp Ile Gly Asn Ala Asn 
        35                  40                  45              


Glu Leu Asn Ala Ser Tyr Met Ala Asp Gly Tyr Ala Arg Thr Lys Lys 
    50                  55                  60                  


Ala Ala Ala Phe Leu Thr Thr Phe Gly Val Gly Glu Leu Ser Ala Ile 
65                  70                  75                  80  


Asn Gly Leu Ala Gly Ser Tyr Ala Glu Asn Leu Pro Val Val Glu Ile 
                85                  90                  95      


Val Gly Ser Pro Thr Ser Lys Val Gln Asn Asp Gly Lys Phe Val His 
            100                 105                 110         


His Thr Leu Ala Asp Gly Asp Phe Lys His Phe Met Lys Met His Glu 
        115                 120                 125             


Pro Val Thr Ala Ala Arg Thr Leu Leu Thr Ala Glu Asn Ala Thr Tyr 
    130                 135                 140                 


Glu Ile Asp Arg Val Leu Ser Gln Leu Leu Lys Glu Arg Lys Pro Val 
145                 150                 155                 160 


Tyr Ile Asn Leu Pro Val Asp Val Ala Ala Ala Lys Ala Glu Lys Pro 
                165                 170                 175     


Ala Leu Ser Leu Glu Lys Glu Ser Ser Thr Thr Asn Thr Thr Glu Gln 
            180                 185                 190         


Val Ile Leu Ser Lys Ile Glu Glu Ser Leu Lys Asn Ala Gln Lys Pro 
        195                 200                 205             


Val Val Ile Ala Gly His Glu Val Ile Ser Phe Gly Leu Glu Lys Thr 
    210                 215                 220                 


Val Thr Gln Phe Val Ser Glu Thr Lys Leu Pro Ile Thr Thr Leu Asn 
225                 230                 235                 240 


Phe Gly Lys Ser Ala Val Asp Glu Ser Leu Pro Ser Phe Leu Gly Ile 
                245                 250                 255     


Tyr Asn Gly Lys Leu Ser Glu Ile Ser Leu Lys Asn Phe Val Glu Ser 
            260                 265                 270         


Ala Asp Phe Ile Leu Met Leu Gly Val Lys Leu Thr Asp Ser Ser Thr 
        275                 280                 285             


Gly Ala Phe Thr His His Leu Asp Glu Asn Lys Met Ile Ser Leu Asn 
    290                 295                 300                 


Ile Asp Glu Gly Ile Ile Phe Asn Lys Val Val Glu Asp Phe Asp Phe 
305                 310                 315                 320 


Arg Ala Val Val Ser Ser Leu Ser Glu Leu Lys Gly Ile Glu Tyr Glu 
                325                 330                 335     


Gly Gln Tyr Ile Asp Lys Gln Tyr Glu Glu Phe Ile Pro Ser Ser Ala 
            340                 345                 350         


Pro Leu Ser Gln Asp Arg Leu Trp Gln Ala Val Glu Ser Leu Thr Gln 
        355                 360                 365             


Ser Asn Glu Thr Ile Val Ala Glu Gln Gly Thr Ser Phe Phe Gly Ala 
    370                 375                 380                 


Ser Thr Ile Phe Leu Lys Ser Asn Ser Arg Phe Ile Gly Gln Pro Leu 
385                 390                 395                 400 


Trp Gly Ser Ile Gly Tyr Thr Phe Pro Ala Ala Leu Gly Ser Gln Ile 
                405                 410                 415     


Ala Asp Lys Glu Ser Arg His Leu Leu Phe Ile Gly Asp Gly Ser Leu 
            420                 425                 430         


Gln Leu Thr Val Gln Glu Leu Gly Leu Ser Ile Arg Glu Lys Leu Asn 
        435                 440                 445             


Pro Ile Cys Phe Ile Ile Asn Asn Asp Gly Tyr Thr Val Glu Arg Glu 
    450                 455                 460                 


Ile His Gly Pro Thr Gln Ser Tyr Asn Asp Ile Pro Met Trp Asn Tyr 
465                 470                 475                 480 


Ser Lys Leu Pro Glu Thr Phe Gly Ala Thr Glu Asp Arg Val Val Ser 
                485                 490                 495     


Lys Ile Val Arg Thr Glu Asn Glu Phe Val Ser Val Met Lys Glu Ala 
            500                 505                 510         


Gln Ala Asp Val Asn Arg Met Tyr Trp Ile Glu Leu Val Leu Glu Lys 
        515                 520                 525             


Glu Asp Ala Pro Lys Leu Leu Lys Lys Met Gly Lys Leu Phe Ala Glu 
    530                 535                 540                 


Gln Asn Lys 
545         


<210>  116
<211>  1644
<212>  DNA
<213>  Artificial

<220>
<223>  Lactococcus lactis branched chain alpha-ketoacid decarboxylase 
       KdcA codon optimised gene

<400>  116
atgtatactg ttggtgatta tctgctggac cgtctgcatg aactgggcat tgaagaaatc     60

ttcggtgtcc caggcgacta caacctgcag ttcctggacc agatcatctc ccgcgaagat    120

atgaaatgga tcggtaacgc aaacgagctg aacgcgtctt atatggctga tggttatgct    180

cgcaccaaaa aggctgcggc ctttctgacc acctttggtg tgggcgagct gagcgcgatc    240

aacggcctgg caggttccta cgctgagaac ctgccggtag tagaaatcgt tggttccccg    300

acctctaagg ttcagaacga cggcaaattc gtacatcaca ccctggcgga cggcgatttt    360

aagcacttta tgaaaatgca cgaaccggtc accgccgctc gcactctgct gaccgcggaa    420

aacgcaacgt acgagatcga tcgtgtactg tcccagctgc tgaaagaacg taaaccggtg    480

tatatcaatc tgccggttga tgtcgctgcg gccaaagcag agaaaccggc actgtccctg    540

gagaaggaga gctccactac taacaccacc gaacaggtta tcctgtccaa aattgaagaa    600

tctctgaaaa acgcacagaa accggtggtt atcgcaggtc acgaggttat ctccttcggc    660

ctggagaaaa ctgttactca attcgtctct gaaacgaaac tgccgatcac gaccctgaac    720

tttggcaagt ccgcagttga cgaatctctg ccttctttcc tgggcattta caacggcaaa    780

ctgtccgaga tctccctgaa gaacttcgta gaatccgctg actttatcct gatgctgggt    840

gtgaaactga ccgactcctc taccggtgcg ttcacgcacc atctggatga aaacaaaatg    900

atcagcctga acatcgacga gggtatcatc ttcaacaagg tagttgaaga tttcgacttc    960

cgtgctgttg tcagcagcct gtccgagctg aaaggcattg agtacgaggg tcaatacatc   1020

gataaacagt acgaagagtt tattccgtct tctgcaccgc tgagccagga ccgcctgtgg   1080

caggcagttg agtccctgac gcagtccaac gaaactatcg tagcggaaca aggtacctct   1140

ttcttcggtg cttctaccat ctttctgaag tccaactctc gctttatcgg tcagccgctg   1200

tggggttcta tcggttacac gttcccggct gcgctgggta gccagatcgc tgataaagag   1260

tctcgtcatc tgctgttcat cggtgatggt tccctgcagc tgactgtaca ggaactgggt   1320

ctgtctatcc gtgaaaaact gaacccgatt tgttttatca tcaataacga tggctacact   1380

gttgagcgtg aaattcatgg tccgactcag tcttacaacg atattccgat gtggaactac   1440

tctaaactgc cggaaacctt cggtgcaact gaggatcgcg tcgtgagcaa gattgtgcgt   1500

actgagaacg agttcgtatc tgttatgaaa gaggcgcagg cagatgtgaa ccgcatgtac   1560

tggatcgaac tggttctgga aaaagaggat gcaccgaaac tgctgaagaa aatgggtaaa   1620

ctgtttgcgg agcagaacaa gtaa                                          1644


<210>  117
<211>  1647
<212>  DNA
<213>  Lactococcus lactis


<220>
<221>  CDS
<222>  (1)..(1647)

<400>  117
atg tat aca gta gga gat tac cta tta gac cga tta cac gag tta gga       48
Met Tyr Thr Val Gly Asp Tyr Leu Leu Asp Arg Leu His Glu Leu Gly         
1               5                   10                  15              

att gaa gaa att ttt gga gtc cct gga gac tat aac tta caa ttt tta       96
Ile Glu Glu Ile Phe Gly Val Pro Gly Asp Tyr Asn Leu Gln Phe Leu         
            20                  25                  30                  

gat caa att att tcc cac aag gat atg aaa tgg gtc gga aat gct aat      144
Asp Gln Ile Ile Ser His Lys Asp Met Lys Trp Val Gly Asn Ala Asn         
        35                  40                  45                      

gaa tta aat gct tca tat atg gct gat ggc tat gct cgt act aaa aaa      192
Glu Leu Asn Ala Ser Tyr Met Ala Asp Gly Tyr Ala Arg Thr Lys Lys         
    50                  55                  60                          

gct gcc gca ttt ctt aca acc ttt gga gta ggt gaa ttg agt gca gtt      240
Ala Ala Ala Phe Leu Thr Thr Phe Gly Val Gly Glu Leu Ser Ala Val         
65                  70                  75                  80          

aat gga tta gca gga agt tac gcc gaa aat tta cca gta gta gaa ata      288
Asn Gly Leu Ala Gly Ser Tyr Ala Glu Asn Leu Pro Val Val Glu Ile         
                85                  90                  95              

gtg gga tca cct aca tca aaa gtt caa aat gaa gga aaa ttt gtt cat      336
Val Gly Ser Pro Thr Ser Lys Val Gln Asn Glu Gly Lys Phe Val His         
            100                 105                 110                 

cat acg ctg gct gac ggt gat ttt aaa cac ttt atg aaa atg cac gaa      384
His Thr Leu Ala Asp Gly Asp Phe Lys His Phe Met Lys Met His Glu         
        115                 120                 125                     

cct gtt aca gca gct cga act tta ctg aca gca gaa aat gca acc gtt      432
Pro Val Thr Ala Ala Arg Thr Leu Leu Thr Ala Glu Asn Ala Thr Val         
    130                 135                 140                         

gaa att gac cga gta ctt tct gca cta tta aaa gaa aga aaa cct gtc      480
Glu Ile Asp Arg Val Leu Ser Ala Leu Leu Lys Glu Arg Lys Pro Val         
145                 150                 155                 160         

tat atc aac tta cca gtt gat gtt gct gct gca aaa gca gag aaa ccc      528
Tyr Ile Asn Leu Pro Val Asp Val Ala Ala Ala Lys Ala Glu Lys Pro         
                165                 170                 175             

tca ctc cct ttg aaa aag gaa aac tca act tca aat aca agt gac caa      576
Ser Leu Pro Leu Lys Lys Glu Asn Ser Thr Ser Asn Thr Ser Asp Gln         
            180                 185                 190                 

gaa att ttg aac aaa att caa gaa agc ttg aaa aat gcc aaa aaa cca      624
Glu Ile Leu Asn Lys Ile Gln Glu Ser Leu Lys Asn Ala Lys Lys Pro         
        195                 200                 205                     

atc gtg att aca gga cat gaa ata att agt ttt ggc tta gaa aaa aca      672
Ile Val Ile Thr Gly His Glu Ile Ile Ser Phe Gly Leu Glu Lys Thr         
    210                 215                 220                         

gtc act caa ttt att tca aag aca aaa cta cct att acg aca tta aac      720
Val Thr Gln Phe Ile Ser Lys Thr Lys Leu Pro Ile Thr Thr Leu Asn         
225                 230                 235                 240         

ttt ggt aaa agt tca gtt gat gaa gcc ctc cct tca ttt tta gga atc      768
Phe Gly Lys Ser Ser Val Asp Glu Ala Leu Pro Ser Phe Leu Gly Ile         
                245                 250                 255             

tat aat ggt aca ctc tca gag cct aat ctt aaa gaa ttc gtg gaa tca      816
Tyr Asn Gly Thr Leu Ser Glu Pro Asn Leu Lys Glu Phe Val Glu Ser         
            260                 265                 270                 

gcc gac ttc atc ttg atg ctt gga gtt aaa ctc aca gac tct tca aca      864
Ala Asp Phe Ile Leu Met Leu Gly Val Lys Leu Thr Asp Ser Ser Thr         
        275                 280                 285                     

gga gcc ttc act cat cat tta aat gaa aat aaa atg att tca ctg aat      912
Gly Ala Phe Thr His His Leu Asn Glu Asn Lys Met Ile Ser Leu Asn         
    290                 295                 300                         

ata gat gaa gga aaa ata ttt aac gaa aga atc caa aat ttt gat ttt      960
Ile Asp Glu Gly Lys Ile Phe Asn Glu Arg Ile Gln Asn Phe Asp Phe         
305                 310                 315                 320         

gaa tcc ctc atc tcc tct ctc tta gac cta agc gaa ata gaa tac aaa     1008
Glu Ser Leu Ile Ser Ser Leu Leu Asp Leu Ser Glu Ile Glu Tyr Lys         
                325                 330                 335             

gga aaa tat atc gat aaa aag caa gaa gac ttt gtt cca tca aat gcg     1056
Gly Lys Tyr Ile Asp Lys Lys Gln Glu Asp Phe Val Pro Ser Asn Ala         
            340                 345                 350                 

ctt tta tca caa gac cgc cta tgg caa gca gtt gaa aac cta act caa     1104
Leu Leu Ser Gln Asp Arg Leu Trp Gln Ala Val Glu Asn Leu Thr Gln         
        355                 360                 365                     

agc aat gaa aca atc gtt gct gaa caa ggg aca tca ttc ttt ggc gct     1152
Ser Asn Glu Thr Ile Val Ala Glu Gln Gly Thr Ser Phe Phe Gly Ala         
    370                 375                 380                         

tca tca att ttc tta aaa tca aag agt cat ttt att ggt caa ccc tta     1200
Ser Ser Ile Phe Leu Lys Ser Lys Ser His Phe Ile Gly Gln Pro Leu         
385                 390                 395                 400         

tgg gga tca att gga tat aca ttc cca gca gca tta gga agc caa att     1248
Trp Gly Ser Ile Gly Tyr Thr Phe Pro Ala Ala Leu Gly Ser Gln Ile         
                405                 410                 415             

gca gat aaa gaa agc aga cac ctt tta ttt att ggt gat ggt tca ctt     1296
Ala Asp Lys Glu Ser Arg His Leu Leu Phe Ile Gly Asp Gly Ser Leu         
            420                 425                 430                 

caa ctt aca gtg caa gaa tta gga tta gca atc aga gaa aaa att aat     1344
Gln Leu Thr Val Gln Glu Leu Gly Leu Ala Ile Arg Glu Lys Ile Asn         
        435                 440                 445                     

cca att tgc ttt att atc aat aat gat ggt tat aca gtc gaa aga gaa     1392
Pro Ile Cys Phe Ile Ile Asn Asn Asp Gly Tyr Thr Val Glu Arg Glu         
    450                 455                 460                         

att cat gga cca aat caa agc tac aat gat att cca atg tgg aat tac     1440
Ile His Gly Pro Asn Gln Ser Tyr Asn Asp Ile Pro Met Trp Asn Tyr         
465                 470                 475                 480         

tca aaa tta cca gaa tcg ttt gga gca aca gaa gat cga gta gtc tca     1488
Ser Lys Leu Pro Glu Ser Phe Gly Ala Thr Glu Asp Arg Val Val Ser         
                485                 490                 495             

aaa atc gtt aga act gaa aat gaa ttt gtg tct gtc atg aaa gaa gct     1536
Lys Ile Val Arg Thr Glu Asn Glu Phe Val Ser Val Met Lys Glu Ala         
            500                 505                 510                 

caa gca gat cca aat aga atg tac tgg att gag tta att ttg gca aaa     1584
Gln Ala Asp Pro Asn Arg Met Tyr Trp Ile Glu Leu Ile Leu Ala Lys         
        515                 520                 525                     

gaa ggt gca cca aaa gta ctg aaa aaa atg ggc aaa cta ttt gct gaa     1632
Glu Gly Ala Pro Lys Val Leu Lys Lys Met Gly Lys Leu Phe Ala Glu         
    530                 535                 540                         

caa aat aaa tca taa                                                 1647
Gln Asn Lys Ser                                                         
545                                                                     


<210>  118
<211>  548
<212>  PRT
<213>  Lactococcus lactis

<400>  118

Met Tyr Thr Val Gly Asp Tyr Leu Leu Asp Arg Leu His Glu Leu Gly 
1               5                   10                  15      


Ile Glu Glu Ile Phe Gly Val Pro Gly Asp Tyr Asn Leu Gln Phe Leu 
            20                  25                  30          


Asp Gln Ile Ile Ser His Lys Asp Met Lys Trp Val Gly Asn Ala Asn 
        35                  40                  45              


Glu Leu Asn Ala Ser Tyr Met Ala Asp Gly Tyr Ala Arg Thr Lys Lys 
    50                  55                  60                  


Ala Ala Ala Phe Leu Thr Thr Phe Gly Val Gly Glu Leu Ser Ala Val 
65                  70                  75                  80  


Asn Gly Leu Ala Gly Ser Tyr Ala Glu Asn Leu Pro Val Val Glu Ile 
                85                  90                  95      


Val Gly Ser Pro Thr Ser Lys Val Gln Asn Glu Gly Lys Phe Val His 
            100                 105                 110         


His Thr Leu Ala Asp Gly Asp Phe Lys His Phe Met Lys Met His Glu 
        115                 120                 125             


Pro Val Thr Ala Ala Arg Thr Leu Leu Thr Ala Glu Asn Ala Thr Val 
    130                 135                 140                 


Glu Ile Asp Arg Val Leu Ser Ala Leu Leu Lys Glu Arg Lys Pro Val 
145                 150                 155                 160 


Tyr Ile Asn Leu Pro Val Asp Val Ala Ala Ala Lys Ala Glu Lys Pro 
                165                 170                 175     


Ser Leu Pro Leu Lys Lys Glu Asn Ser Thr Ser Asn Thr Ser Asp Gln 
            180                 185                 190         


Glu Ile Leu Asn Lys Ile Gln Glu Ser Leu Lys Asn Ala Lys Lys Pro 
        195                 200                 205             


Ile Val Ile Thr Gly His Glu Ile Ile Ser Phe Gly Leu Glu Lys Thr 
    210                 215                 220                 


Val Thr Gln Phe Ile Ser Lys Thr Lys Leu Pro Ile Thr Thr Leu Asn 
225                 230                 235                 240 


Phe Gly Lys Ser Ser Val Asp Glu Ala Leu Pro Ser Phe Leu Gly Ile 
                245                 250                 255     


Tyr Asn Gly Thr Leu Ser Glu Pro Asn Leu Lys Glu Phe Val Glu Ser 
            260                 265                 270         


Ala Asp Phe Ile Leu Met Leu Gly Val Lys Leu Thr Asp Ser Ser Thr 
        275                 280                 285             


Gly Ala Phe Thr His His Leu Asn Glu Asn Lys Met Ile Ser Leu Asn 
    290                 295                 300                 


Ile Asp Glu Gly Lys Ile Phe Asn Glu Arg Ile Gln Asn Phe Asp Phe 
305                 310                 315                 320 


Glu Ser Leu Ile Ser Ser Leu Leu Asp Leu Ser Glu Ile Glu Tyr Lys 
                325                 330                 335     


Gly Lys Tyr Ile Asp Lys Lys Gln Glu Asp Phe Val Pro Ser Asn Ala 
            340                 345                 350         


Leu Leu Ser Gln Asp Arg Leu Trp Gln Ala Val Glu Asn Leu Thr Gln 
        355                 360                 365             


Ser Asn Glu Thr Ile Val Ala Glu Gln Gly Thr Ser Phe Phe Gly Ala 
    370                 375                 380                 


Ser Ser Ile Phe Leu Lys Ser Lys Ser His Phe Ile Gly Gln Pro Leu 
385                 390                 395                 400 


Trp Gly Ser Ile Gly Tyr Thr Phe Pro Ala Ala Leu Gly Ser Gln Ile 
                405                 410                 415     


Ala Asp Lys Glu Ser Arg His Leu Leu Phe Ile Gly Asp Gly Ser Leu 
            420                 425                 430         


Gln Leu Thr Val Gln Glu Leu Gly Leu Ala Ile Arg Glu Lys Ile Asn 
        435                 440                 445             


Pro Ile Cys Phe Ile Ile Asn Asn Asp Gly Tyr Thr Val Glu Arg Glu 
    450                 455                 460                 


Ile His Gly Pro Asn Gln Ser Tyr Asn Asp Ile Pro Met Trp Asn Tyr 
465                 470                 475                 480 


Ser Lys Leu Pro Glu Ser Phe Gly Ala Thr Glu Asp Arg Val Val Ser 
                485                 490                 495     


Lys Ile Val Arg Thr Glu Asn Glu Phe Val Ser Val Met Lys Glu Ala 
            500                 505                 510         


Gln Ala Asp Pro Asn Arg Met Tyr Trp Ile Glu Leu Ile Leu Ala Lys 
        515                 520                 525             


Glu Gly Ala Pro Lys Val Leu Lys Lys Met Gly Lys Leu Phe Ala Glu 
    530                 535                 540                 


Gln Asn Lys Ser 
545             


<210>  119
<211>  1647
<212>  DNA
<213>  Artificial

<220>
<223>  Lactococcus lactis  -ketoisovalerate decarboxylase KivD codon 
       optimised gene

<400>  119
atgtatactg ttggtgatta cctgctggat cgtctgcatg aactgggcat cgaggaaatt     60

ttcggcgtac ctggtgacta taacctgcag ttcctggatc agatcatttc ccacaaagat    120

atgaaatggg ttggtaacgc gaacgagctg aatgcaagct acatggctga cggttatgca    180

cgcaccaaga aagctgcggc gttcctgact acttttggcg tcggcgagct gtctgcggta    240

aacggtctgg ccggctccta cgcggaaaac ctgccggtag tagaaatcgt cggttccccg    300

acctctaaag ttcagaacga gggtaaattc gtgcaccata ctctggccga tggtgacttc    360

aaacacttca tgaagatgca cgaaccggtc actgctgctc gtacgctgct gaccgcggaa    420

aatgcgactg tcgagattga tcgtgtactg agcgcactgc tgaaagaacg caagcctgta    480

tacatcaacc tgccggttga tgtcgcggcc gccaaagcgg aaaaaccatc tctgccgctg    540

aaaaaggaga acagcacctc taacaccagc gaccaggaaa tcctgaacaa gatccaggag    600

tctctgaaga acgctaaaaa gccgatcgta atcaccggcc atgagattat ctctttcggt    660

ctggagaaaa ctgtcaccca gttcatcagc aaaaccaaac tgccgatcac caccctgaac    720

ttcggtaaat cctccgttga cgaagcgctg ccgtcctttc tgggtattta caacggcact    780

ctgtctgagc cgaacctgaa agagttcgtg gagtctgcgg attttatcct gatgctgggc    840

gtgaaactga cggattcctc caccggtgca ttcacccacc acctgaatga gaataaaatg    900

atctctctga acattgatga gggcaaaatc ttcaacgagc gtattcagaa cttcgatttc    960

gaatccctga tctcctccct gctggatctg tccgagattg aatataaagg caaatacatt   1020

gataagaagc aagaggactt cgtaccgtct aacgcgctgc tgagccagga ccgtctgtgg   1080

caagctgtgg aaaacctgac ccagtccaac gaaaccatcg tggcggaaca gggtacctcc   1140

ttcttcggtg ctagctctat cttcctgaaa tctaaaagcc acttcatcgg tcagccactg   1200

tggggctcta ttggctacac cttcccggca gcgctgggtt cccaaatcgc agacaaagaa   1260

tcccgccacc tgctgttcat tggtgacggc tctctgcaac tgaccgtaca ggagctgggt   1320

ctggcgattc gtgagaaaat caacccgatt tgtttcatca tcaacaacga tggctacact   1380

gttgagcgtg agatccacgg cccgaaccag tcctacaacg acattccgat gtggaactac   1440

tctaaactgc cggaatcctt cggtgcgact gaagaccgtg tcgtaagcaa gatcgtccgt   1500

accgaaaacg aattcgtgtc tgtcatgaaa gaagcacagg cggacccgaa ccgcatgtac   1560

tggatcgagc tgattctggc taaagagggc gcgccaaaag tactgaaaaa gatgggtaaa   1620

ctgttcgcag aacagaacaa atcctaa                                       1647


<210>  120
<211>  3696
<212>  DNA
<213>  Mycobacterium tuberculosis


<220>
<221>  CDS
<222>  (1)..(3696)

<400>  120
gtg gcc aac ata agt tca cca ttc ggg caa aac gaa tgg ctg gtc gaa       48
Val Ala Asn Ile Ser Ser Pro Phe Gly Gln Asn Glu Trp Leu Val Glu         
1               5                   10                  15              

gag atg tac cgc aag ttc cgc gac gac ccc tcc tcg gtc gat ccc agc       96
Glu Met Tyr Arg Lys Phe Arg Asp Asp Pro Ser Ser Val Asp Pro Ser         
            20                  25                  30                  

tgg cac gag ttc ctg gtt gac tac agc ccc gaa ccc acc tcc caa cca      144
Trp His Glu Phe Leu Val Asp Tyr Ser Pro Glu Pro Thr Ser Gln Pro         
        35                  40                  45                      

gct gcc gaa cca acc cgg gtt acc tcg cca ctc gtt gcc gag cgg gcc      192
Ala Ala Glu Pro Thr Arg Val Thr Ser Pro Leu Val Ala Glu Arg Ala         
    50                  55                  60                          

gct gcg gcc gcc ccg cag gca ccc ccc aag ccg gcc gac acc gcg gcc      240
Ala Ala Ala Ala Pro Gln Ala Pro Pro Lys Pro Ala Asp Thr Ala Ala         
65                  70                  75                  80          

gcg ggc aac ggc gtg gtc gcc gca ctg gcc gcc aaa act gcc gtt ccc      288
Ala Gly Asn Gly Val Val Ala Ala Leu Ala Ala Lys Thr Ala Val Pro         
                85                  90                  95              

ccg cca gcc gaa ggt gac gag gta gcg gtg ctg cgc ggc gcc gcc gcg      336
Pro Pro Ala Glu Gly Asp Glu Val Ala Val Leu Arg Gly Ala Ala Ala         
            100                 105                 110                 

gcc gtc gtc aag aac atg tcc gcg tcg ttg gag gtg ccg acg gcg acc      384
Ala Val Val Lys Asn Met Ser Ala Ser Leu Glu Val Pro Thr Ala Thr         
        115                 120                 125                     

agc gtc cgg gcg gtc ccg gcc aag cta ctg atc gac aac cgg atc gtc      432
Ser Val Arg Ala Val Pro Ala Lys Leu Leu Ile Asp Asn Arg Ile Val         
    130                 135                 140                         

atc aac aac cag ttg aag cgg acc cgc ggc ggc aag atc tcg ttc acg      480
Ile Asn Asn Gln Leu Lys Arg Thr Arg Gly Gly Lys Ile Ser Phe Thr         
145                 150                 155                 160         

cat ttg ctg ggc tac gcc ctg gtg cag gcg gtg aag aaa ttc ccg aac      528
His Leu Leu Gly Tyr Ala Leu Val Gln Ala Val Lys Lys Phe Pro Asn         
                165                 170                 175             

atg aac cgg cac tac acc gaa gtc gac ggc aag ccc acc gcg gtc acg      576
Met Asn Arg His Tyr Thr Glu Val Asp Gly Lys Pro Thr Ala Val Thr         
            180                 185                 190                 

ccg gcg cac acc aat ctc ggc ctg gcg atc gac ctg caa ggc aag gac      624
Pro Ala His Thr Asn Leu Gly Leu Ala Ile Asp Leu Gln Gly Lys Asp         
        195                 200                 205                     

ggg aag cgt tcc ctg gtg gtg gcc ggc atc aag cgg tgc gag acc atg      672
Gly Lys Arg Ser Leu Val Val Ala Gly Ile Lys Arg Cys Glu Thr Met         
    210                 215                 220                         

cga ttc gcg cag ttc gtc acg gcc tac gaa gac atc gta cgc cgg gcc      720
Arg Phe Ala Gln Phe Val Thr Ala Tyr Glu Asp Ile Val Arg Arg Ala         
225                 230                 235                 240         

cgc gac ggc aag ctg acc act gaa gac ttt gcc ggc gtg acg att tcg      768
Arg Asp Gly Lys Leu Thr Thr Glu Asp Phe Ala Gly Val Thr Ile Ser         
                245                 250                 255             

ctg acc aat ccc gga acc atc ggc acc gtg cat tcg gtg ccg cgg ctg      816
Leu Thr Asn Pro Gly Thr Ile Gly Thr Val His Ser Val Pro Arg Leu         
            260                 265                 270                 

atg ccc ggc cag ggc gcc atc atc ggc gtg ggc gcc atg gaa tac ccc      864
Met Pro Gly Gln Gly Ala Ile Ile Gly Val Gly Ala Met Glu Tyr Pro         
        275                 280                 285                     

gcc gag ttt caa ggc gcc agc gag gaa cgc atc gcc gag ctg ggc atc      912
Ala Glu Phe Gln Gly Ala Ser Glu Glu Arg Ile Ala Glu Leu Gly Ile         
    290                 295                 300                         

ggc aaa ttg atc act ttg acc tcc acc tac gac cac cgc atc atc cag      960
Gly Lys Leu Ile Thr Leu Thr Ser Thr Tyr Asp His Arg Ile Ile Gln         
305                 310                 315                 320         

ggc gcg gaa tcg ggc gac ttc ctg cgc acc atc cac gag ttg ctg ctc     1008
Gly Ala Glu Ser Gly Asp Phe Leu Arg Thr Ile His Glu Leu Leu Leu         
                325                 330                 335             

tcg gat ggc ttc tgg gac gag gtc ttc cgc gaa ctg agc atc cca tat     1056
Ser Asp Gly Phe Trp Asp Glu Val Phe Arg Glu Leu Ser Ile Pro Tyr         
            340                 345                 350                 

ctg ccg gtg cgc tgg agc acc gac aac ccc gac tcg atc gtc gac aag     1104
Leu Pro Val Arg Trp Ser Thr Asp Asn Pro Asp Ser Ile Val Asp Lys         
        355                 360                 365                     

aac gct cgc gtc atg aac ttg atc gcg gcc tac cgc aac cgc ggc cat     1152
Asn Ala Arg Val Met Asn Leu Ile Ala Ala Tyr Arg Asn Arg Gly His         
    370                 375                 380                         

ctg atg gcc gat acc gac ccg ctg cgg ttg gac aaa gct cgg ttc cgc     1200
Leu Met Ala Asp Thr Asp Pro Leu Arg Leu Asp Lys Ala Arg Phe Arg         
385                 390                 395                 400         

agt cac ccc gac ctc gaa gtg ctg acc cac ggc ctg acg ctg tgg gat     1248
Ser His Pro Asp Leu Glu Val Leu Thr His Gly Leu Thr Leu Trp Asp         
                405                 410                 415             

ctc gat cgg gtg ttc aag gtc gac ggc ttt gcc ggt gcg cag tac aag     1296
Leu Asp Arg Val Phe Lys Val Asp Gly Phe Ala Gly Ala Gln Tyr Lys         
            420                 425                 430                 

aaa ctg cgc gac gtg ctg ggc ttg ctg cgc gat gcc tac tgc cgc cac     1344
Lys Leu Arg Asp Val Leu Gly Leu Leu Arg Asp Ala Tyr Cys Arg His         
        435                 440                 445                     

atc ggc gtg gag tac gcc cat atc ctc gac ccc gaa caa aag gag tgg     1392
Ile Gly Val Glu Tyr Ala His Ile Leu Asp Pro Glu Gln Lys Glu Trp         
    450                 455                 460                         

ctc gaa caa cgg gtc gag acc aag cac gtc aaa ccc act gtg gcc caa     1440
Leu Glu Gln Arg Val Glu Thr Lys His Val Lys Pro Thr Val Ala Gln         
465                 470                 475                 480         

cag aaa tac atc ctc agc aag ctc aac gcc gcc gag gcc ttt gaa acg     1488
Gln Lys Tyr Ile Leu Ser Lys Leu Asn Ala Ala Glu Ala Phe Glu Thr         
                485                 490                 495             

ttc cta cag acc aag tac gtc ggc cag aag cgg ttc tcg ctg gaa ggc     1536
Phe Leu Gln Thr Lys Tyr Val Gly Gln Lys Arg Phe Ser Leu Glu Gly         
            500                 505                 510                 

gcc gaa agc gtg atc ccg atg atg gac gcg gcg atc gac cag tgc gct     1584
Ala Glu Ser Val Ile Pro Met Met Asp Ala Ala Ile Asp Gln Cys Ala         
        515                 520                 525                     

gag cac ggc ctc gac gag gtg gtc atc ggg atg ccg cac cgg ggc cgg     1632
Glu His Gly Leu Asp Glu Val Val Ile Gly Met Pro His Arg Gly Arg         
    530                 535                 540                         

ctc aac gtg ctg gcc aac atc gtc ggc aag ccg tac tcg cag atc ttc     1680
Leu Asn Val Leu Ala Asn Ile Val Gly Lys Pro Tyr Ser Gln Ile Phe         
545                 550                 555                 560         

acc gag ttc gag ggc aac ctg aat ccg tcg cag gcg cac ggc tcc ggt     1728
Thr Glu Phe Glu Gly Asn Leu Asn Pro Ser Gln Ala His Gly Ser Gly         
                565                 570                 575             

gac gtc aag tac cac ctg ggc gcc acc ggg ctg tac ctg cag atg ttc     1776
Asp Val Lys Tyr His Leu Gly Ala Thr Gly Leu Tyr Leu Gln Met Phe         
            580                 585                 590                 

ggc gac aac gac att cag gtg tcg ctg acc gcc aac ccg tcg cat ctg     1824
Gly Asp Asn Asp Ile Gln Val Ser Leu Thr Ala Asn Pro Ser His Leu         
        595                 600                 605                     

gag gcc gtc gac ccg gtg ctg gag gga ttg gtg cgg gcc aag cag gat     1872
Glu Ala Val Asp Pro Val Leu Glu Gly Leu Val Arg Ala Lys Gln Asp         
    610                 615                 620                         

ctg ctc gac cac gga agc atc gac agc gac ggc caa cgg gcg ttc tcg     1920
Leu Leu Asp His Gly Ser Ile Asp Ser Asp Gly Gln Arg Ala Phe Ser         
625                 630                 635                 640         

gtg gtg ccg ctg atg ttg cat ggc gat gcc gcg ttc gcc ggt cag ggt     1968
Val Val Pro Leu Met Leu His Gly Asp Ala Ala Phe Ala Gly Gln Gly         
                645                 650                 655             

gtg gtc gcc gag acg ctg aac ctg gcg aat ctg ccg ggc tac cgc gtc     2016
Val Val Ala Glu Thr Leu Asn Leu Ala Asn Leu Pro Gly Tyr Arg Val         
            660                 665                 670                 

ggc ggc acc atc cac atc atc gtc aac aac cag atc ggc ttc acc acc     2064
Gly Gly Thr Ile His Ile Ile Val Asn Asn Gln Ile Gly Phe Thr Thr         
        675                 680                 685                     

gcg ccc gag tat tcc agg tcc agc gag tac tgc acc gac gtc gca aag     2112
Ala Pro Glu Tyr Ser Arg Ser Ser Glu Tyr Cys Thr Asp Val Ala Lys         
    690                 695                 700                         

atg atc ggg gca ccg atc ttt cac gtc aac ggc gac gac ccg gag gcg     2160
Met Ile Gly Ala Pro Ile Phe His Val Asn Gly Asp Asp Pro Glu Ala         
705                 710                 715                 720         

tgt gtc tgg gtg gcg cgg ttg gcg gtg gac ttc cga caa cgg ttc aag     2208
Cys Val Trp Val Ala Arg Leu Ala Val Asp Phe Arg Gln Arg Phe Lys         
                725                 730                 735             

aag gac gtc gtc atc gac atg ctg tgc tac cgc cgc cgc ggg cac aac     2256
Lys Asp Val Val Ile Asp Met Leu Cys Tyr Arg Arg Arg Gly His Asn         
            740                 745                 750                 

gag ggt gac gac ccg tcg atg acc aac ccc tac gtg tac gac gtc gtc     2304
Glu Gly Asp Asp Pro Ser Met Thr Asn Pro Tyr Val Tyr Asp Val Val         
        755                 760                 765                     

gac acc aag cgc ggg gcc cgc aaa agc tac acc gaa gcc ctg atc gga     2352
Asp Thr Lys Arg Gly Ala Arg Lys Ser Tyr Thr Glu Ala Leu Ile Gly         
    770                 775                 780                         

cgt ggc gac atc tcg atg aag gag gcc gag gac gcg ctg cgc gac tac     2400
Arg Gly Asp Ile Ser Met Lys Glu Ala Glu Asp Ala Leu Arg Asp Tyr         
785                 790                 795                 800         

cag ggc cag ctg gaa cgg gtg ttc aac gaa gtg cgc gag ctg gag aag     2448
Gln Gly Gln Leu Glu Arg Val Phe Asn Glu Val Arg Glu Leu Glu Lys         
                805                 810                 815             

cac ggt gtg cag ccg agc gag tcg gtc gag tcc gac cag atg att ccc     2496
His Gly Val Gln Pro Ser Glu Ser Val Glu Ser Asp Gln Met Ile Pro         
            820                 825                 830                 

gcg ggg ctg gcc act gcg gtg gac aag tcg ctg ctg gcc cgg atc ggc     2544
Ala Gly Leu Ala Thr Ala Val Asp Lys Ser Leu Leu Ala Arg Ile Gly         
        835                 840                 845                     

gat gcg ttc ctc gcc ttg ccg aac ggc ttc acc gcg cac ccg cga gtc     2592
Asp Ala Phe Leu Ala Leu Pro Asn Gly Phe Thr Ala His Pro Arg Val         
    850                 855                 860                         

caa ccg gtg ctg gag aag cgc cgg gag atg gcc tat gaa ggc aag atc     2640
Gln Pro Val Leu Glu Lys Arg Arg Glu Met Ala Tyr Glu Gly Lys Ile         
865                 870                 875                 880         

gac tgg gcc ttt ggc gag ctg ctg gcg ctg ggc tcg ctg gtg gcc gaa     2688
Asp Trp Ala Phe Gly Glu Leu Leu Ala Leu Gly Ser Leu Val Ala Glu         
                885                 890                 895             

ggc aag ctg gtg cgc ttg tcg ggg cag gac agc cgc cgc ggc acc ttc     2736
Gly Lys Leu Val Arg Leu Ser Gly Gln Asp Ser Arg Arg Gly Thr Phe         
            900                 905                 910                 

tcc cag cgg cat tcg gtt ctc atc gac cgc cac act ggc gag gag ttc     2784
Ser Gln Arg His Ser Val Leu Ile Asp Arg His Thr Gly Glu Glu Phe         
        915                 920                 925                     

aca cca ctg cag ctg ctg gcg acc aac tcc gac ggc agc ccg acc ggc     2832
Thr Pro Leu Gln Leu Leu Ala Thr Asn Ser Asp Gly Ser Pro Thr Gly         
    930                 935                 940                         

gga aag ttc ctg gtc tac gac tcg cca ctg tcg gag tac gcc gcc gtc     2880
Gly Lys Phe Leu Val Tyr Asp Ser Pro Leu Ser Glu Tyr Ala Ala Val         
945                 950                 955                 960         

ggc ttc gag tac ggc tac act gtg ggc aat ccg gac gcc gtg gtg ctc     2928
Gly Phe Glu Tyr Gly Tyr Thr Val Gly Asn Pro Asp Ala Val Val Leu         
                965                 970                 975             

tgg gag gcg cag ttc ggc gac ttc gtc aac ggc gcg cag tcg atc atc     2976
Trp Glu Ala Gln Phe Gly Asp Phe Val Asn Gly Ala Gln Ser Ile Ile         
            980                 985                 990                 

gac gag ttc atc agc tcc ggt gag  gcc aag tgg ggc caa  ttg tcc aac   3024
Asp Glu Phe Ile Ser Ser Gly Glu  Ala Lys Trp Gly Gln  Leu Ser Asn       
        995                 1000                 1005                   

gtc gtg  ctg ctg tta ccg cac  ggg cac gag ggg cag  gga ccc gac      3069
Val Val  Leu Leu Leu Pro His  Gly His Glu Gly Gln  Gly Pro Asp          
    1010                 1015                 1020                      

cac act  tct gcc cgg atc gaa  cgc ttc ttg cag ttg  tgg gcg gaa      3114
His Thr  Ser Ala Arg Ile Glu  Arg Phe Leu Gln Leu  Trp Ala Glu          
    1025                 1030                 1035                      

ggt tcg  atg acc atc gcg atg  ccg tcg act ccg tcg  aac tac ttc      3159
Gly Ser  Met Thr Ile Ala Met  Pro Ser Thr Pro Ser  Asn Tyr Phe          
    1040                 1045                 1050                      

cac ctg  cta cgc cgg cat gcc  ctg gac ggc atc caa  cgc ccg ctg      3204
His Leu  Leu Arg Arg His Ala  Leu Asp Gly Ile Gln  Arg Pro Leu          
    1055                 1060                 1065                      

atc gtg  ttc acg ccc aag tcg  atg ttg cgt cac aag  gcc gcc gtc      3249
Ile Val  Phe Thr Pro Lys Ser  Met Leu Arg His Lys  Ala Ala Val          
    1070                 1075                 1080                      

agc gaa  atc aag gac ttc acc  gag atc aag ttc cgc  tca gtg ctg      3294
Ser Glu  Ile Lys Asp Phe Thr  Glu Ile Lys Phe Arg  Ser Val Leu          
    1085                 1090                 1095                      

gag gaa  ccc acc tat gag gac  ggc atc gga gac cgc  aac aag gtc      3339
Glu Glu  Pro Thr Tyr Glu Asp  Gly Ile Gly Asp Arg  Asn Lys Val          
    1100                 1105                 1110                      

agc cgg  atc ctg ctg acc agt  ggc aag ctg tat tac  gag ctg gcc      3384
Ser Arg  Ile Leu Leu Thr Ser  Gly Lys Leu Tyr Tyr  Glu Leu Ala          
    1115                 1120                 1125                      

gcc cgc  aag gcc aag gac aac  cgc aat gac ctc gcg  atc gtg cgg      3429
Ala Arg  Lys Ala Lys Asp Asn  Arg Asn Asp Leu Ala  Ile Val Arg          
    1130                 1135                 1140                      

ctt gaa  cag ctc gcc ccg ctg  ccc agg cgt cga ctg  cgt gaa acg      3474
Leu Glu  Gln Leu Ala Pro Leu  Pro Arg Arg Arg Leu  Arg Glu Thr          
    1145                 1150                 1155                      

ctg gac  cgc tac gag aac gtc  aag gag ttc ttc tgg  gtc caa gag      3519
Leu Asp  Arg Tyr Glu Asn Val  Lys Glu Phe Phe Trp  Val Gln Glu          
    1160                 1165                 1170                      

gaa ccg  gcc aac cag ggt gcg  tgg ccg cga ttc ggg  ctc gaa cta      3564
Glu Pro  Ala Asn Gln Gly Ala  Trp Pro Arg Phe Gly  Leu Glu Leu          
    1175                 1180                 1185                      

ccc gag  ctg ctg cct gac aag  ttg gcc ggg atc aag  cga atc tcg      3609
Pro Glu  Leu Leu Pro Asp Lys  Leu Ala Gly Ile Lys  Arg Ile Ser          
    1190                 1195                 1200                      

cgc cgg  gcg atg tca gcc ccg  tcg tca ggc tcg tcg  aag gtg cac      3654
Arg Arg  Ala Met Ser Ala Pro  Ser Ser Gly Ser Ser  Lys Val His          
    1205                 1210                 1215                      

gcc gtc  gaa cag cag gag atc  ctc gac gag gcg ttc  ggc tga          3696
Ala Val  Glu Gln Gln Glu Ile  Leu Asp Glu Ala Phe  Gly                  
    1220                 1225                 1230                      


<210>  121
<211>  1231
<212>  PRT
<213>  Mycobacterium tuberculosis

<400>  121

Val Ala Asn Ile Ser Ser Pro Phe Gly Gln Asn Glu Trp Leu Val Glu 
1               5                   10                  15      


Glu Met Tyr Arg Lys Phe Arg Asp Asp Pro Ser Ser Val Asp Pro Ser 
            20                  25                  30          


Trp His Glu Phe Leu Val Asp Tyr Ser Pro Glu Pro Thr Ser Gln Pro 
        35                  40                  45              


Ala Ala Glu Pro Thr Arg Val Thr Ser Pro Leu Val Ala Glu Arg Ala 
    50                  55                  60                  


Ala Ala Ala Ala Pro Gln Ala Pro Pro Lys Pro Ala Asp Thr Ala Ala 
65                  70                  75                  80  


Ala Gly Asn Gly Val Val Ala Ala Leu Ala Ala Lys Thr Ala Val Pro 
                85                  90                  95      


Pro Pro Ala Glu Gly Asp Glu Val Ala Val Leu Arg Gly Ala Ala Ala 
            100                 105                 110         


Ala Val Val Lys Asn Met Ser Ala Ser Leu Glu Val Pro Thr Ala Thr 
        115                 120                 125             


Ser Val Arg Ala Val Pro Ala Lys Leu Leu Ile Asp Asn Arg Ile Val 
    130                 135                 140                 


Ile Asn Asn Gln Leu Lys Arg Thr Arg Gly Gly Lys Ile Ser Phe Thr 
145                 150                 155                 160 


His Leu Leu Gly Tyr Ala Leu Val Gln Ala Val Lys Lys Phe Pro Asn 
                165                 170                 175     


Met Asn Arg His Tyr Thr Glu Val Asp Gly Lys Pro Thr Ala Val Thr 
            180                 185                 190         


Pro Ala His Thr Asn Leu Gly Leu Ala Ile Asp Leu Gln Gly Lys Asp 
        195                 200                 205             


Gly Lys Arg Ser Leu Val Val Ala Gly Ile Lys Arg Cys Glu Thr Met 
    210                 215                 220                 


Arg Phe Ala Gln Phe Val Thr Ala Tyr Glu Asp Ile Val Arg Arg Ala 
225                 230                 235                 240 


Arg Asp Gly Lys Leu Thr Thr Glu Asp Phe Ala Gly Val Thr Ile Ser 
                245                 250                 255     


Leu Thr Asn Pro Gly Thr Ile Gly Thr Val His Ser Val Pro Arg Leu 
            260                 265                 270         


Met Pro Gly Gln Gly Ala Ile Ile Gly Val Gly Ala Met Glu Tyr Pro 
        275                 280                 285             


Ala Glu Phe Gln Gly Ala Ser Glu Glu Arg Ile Ala Glu Leu Gly Ile 
    290                 295                 300                 


Gly Lys Leu Ile Thr Leu Thr Ser Thr Tyr Asp His Arg Ile Ile Gln 
305                 310                 315                 320 


Gly Ala Glu Ser Gly Asp Phe Leu Arg Thr Ile His Glu Leu Leu Leu 
                325                 330                 335     


Ser Asp Gly Phe Trp Asp Glu Val Phe Arg Glu Leu Ser Ile Pro Tyr 
            340                 345                 350         


Leu Pro Val Arg Trp Ser Thr Asp Asn Pro Asp Ser Ile Val Asp Lys 
        355                 360                 365             


Asn Ala Arg Val Met Asn Leu Ile Ala Ala Tyr Arg Asn Arg Gly His 
    370                 375                 380                 


Leu Met Ala Asp Thr Asp Pro Leu Arg Leu Asp Lys Ala Arg Phe Arg 
385                 390                 395                 400 


Ser His Pro Asp Leu Glu Val Leu Thr His Gly Leu Thr Leu Trp Asp 
                405                 410                 415     


Leu Asp Arg Val Phe Lys Val Asp Gly Phe Ala Gly Ala Gln Tyr Lys 
            420                 425                 430         


Lys Leu Arg Asp Val Leu Gly Leu Leu Arg Asp Ala Tyr Cys Arg His 
        435                 440                 445             


Ile Gly Val Glu Tyr Ala His Ile Leu Asp Pro Glu Gln Lys Glu Trp 
    450                 455                 460                 


Leu Glu Gln Arg Val Glu Thr Lys His Val Lys Pro Thr Val Ala Gln 
465                 470                 475                 480 


Gln Lys Tyr Ile Leu Ser Lys Leu Asn Ala Ala Glu Ala Phe Glu Thr 
                485                 490                 495     


Phe Leu Gln Thr Lys Tyr Val Gly Gln Lys Arg Phe Ser Leu Glu Gly 
            500                 505                 510         


Ala Glu Ser Val Ile Pro Met Met Asp Ala Ala Ile Asp Gln Cys Ala 
        515                 520                 525             


Glu His Gly Leu Asp Glu Val Val Ile Gly Met Pro His Arg Gly Arg 
    530                 535                 540                 


Leu Asn Val Leu Ala Asn Ile Val Gly Lys Pro Tyr Ser Gln Ile Phe 
545                 550                 555                 560 


Thr Glu Phe Glu Gly Asn Leu Asn Pro Ser Gln Ala His Gly Ser Gly 
                565                 570                 575     


Asp Val Lys Tyr His Leu Gly Ala Thr Gly Leu Tyr Leu Gln Met Phe 
            580                 585                 590         


Gly Asp Asn Asp Ile Gln Val Ser Leu Thr Ala Asn Pro Ser His Leu 
        595                 600                 605             


Glu Ala Val Asp Pro Val Leu Glu Gly Leu Val Arg Ala Lys Gln Asp 
    610                 615                 620                 


Leu Leu Asp His Gly Ser Ile Asp Ser Asp Gly Gln Arg Ala Phe Ser 
625                 630                 635                 640 


Val Val Pro Leu Met Leu His Gly Asp Ala Ala Phe Ala Gly Gln Gly 
                645                 650                 655     


Val Val Ala Glu Thr Leu Asn Leu Ala Asn Leu Pro Gly Tyr Arg Val 
            660                 665                 670         


Gly Gly Thr Ile His Ile Ile Val Asn Asn Gln Ile Gly Phe Thr Thr 
        675                 680                 685             


Ala Pro Glu Tyr Ser Arg Ser Ser Glu Tyr Cys Thr Asp Val Ala Lys 
    690                 695                 700                 


Met Ile Gly Ala Pro Ile Phe His Val Asn Gly Asp Asp Pro Glu Ala 
705                 710                 715                 720 


Cys Val Trp Val Ala Arg Leu Ala Val Asp Phe Arg Gln Arg Phe Lys 
                725                 730                 735     


Lys Asp Val Val Ile Asp Met Leu Cys Tyr Arg Arg Arg Gly His Asn 
            740                 745                 750         


Glu Gly Asp Asp Pro Ser Met Thr Asn Pro Tyr Val Tyr Asp Val Val 
        755                 760                 765             


Asp Thr Lys Arg Gly Ala Arg Lys Ser Tyr Thr Glu Ala Leu Ile Gly 
    770                 775                 780                 


Arg Gly Asp Ile Ser Met Lys Glu Ala Glu Asp Ala Leu Arg Asp Tyr 
785                 790                 795                 800 


Gln Gly Gln Leu Glu Arg Val Phe Asn Glu Val Arg Glu Leu Glu Lys 
                805                 810                 815     


His Gly Val Gln Pro Ser Glu Ser Val Glu Ser Asp Gln Met Ile Pro 
            820                 825                 830         


Ala Gly Leu Ala Thr Ala Val Asp Lys Ser Leu Leu Ala Arg Ile Gly 
        835                 840                 845             


Asp Ala Phe Leu Ala Leu Pro Asn Gly Phe Thr Ala His Pro Arg Val 
    850                 855                 860                 


Gln Pro Val Leu Glu Lys Arg Arg Glu Met Ala Tyr Glu Gly Lys Ile 
865                 870                 875                 880 


Asp Trp Ala Phe Gly Glu Leu Leu Ala Leu Gly Ser Leu Val Ala Glu 
                885                 890                 895     


Gly Lys Leu Val Arg Leu Ser Gly Gln Asp Ser Arg Arg Gly Thr Phe 
            900                 905                 910         


Ser Gln Arg His Ser Val Leu Ile Asp Arg His Thr Gly Glu Glu Phe 
        915                 920                 925             


Thr Pro Leu Gln Leu Leu Ala Thr Asn Ser Asp Gly Ser Pro Thr Gly 
    930                 935                 940                 


Gly Lys Phe Leu Val Tyr Asp Ser Pro Leu Ser Glu Tyr Ala Ala Val 
945                 950                 955                 960 


Gly Phe Glu Tyr Gly Tyr Thr Val Gly Asn Pro Asp Ala Val Val Leu 
                965                 970                 975     


Trp Glu Ala Gln Phe Gly Asp Phe Val Asn Gly Ala Gln Ser Ile Ile 
            980                 985                 990         


Asp Glu Phe Ile Ser Ser Gly Glu  Ala Lys Trp Gly Gln  Leu Ser Asn 
        995                 1000                 1005             


Val Val  Leu Leu Leu Pro His  Gly His Glu Gly Gln  Gly Pro Asp 
    1010                 1015                 1020             


His Thr  Ser Ala Arg Ile Glu  Arg Phe Leu Gln Leu  Trp Ala Glu 
    1025                 1030                 1035             


Gly Ser  Met Thr Ile Ala Met  Pro Ser Thr Pro Ser  Asn Tyr Phe 
    1040                 1045                 1050             


His Leu  Leu Arg Arg His Ala  Leu Asp Gly Ile Gln  Arg Pro Leu 
    1055                 1060                 1065             


Ile Val  Phe Thr Pro Lys Ser  Met Leu Arg His Lys  Ala Ala Val 
    1070                 1075                 1080             


Ser Glu  Ile Lys Asp Phe Thr  Glu Ile Lys Phe Arg  Ser Val Leu 
    1085                 1090                 1095             


Glu Glu  Pro Thr Tyr Glu Asp  Gly Ile Gly Asp Arg  Asn Lys Val 
    1100                 1105                 1110             


Ser Arg  Ile Leu Leu Thr Ser  Gly Lys Leu Tyr Tyr  Glu Leu Ala 
    1115                 1120                 1125             


Ala Arg  Lys Ala Lys Asp Asn  Arg Asn Asp Leu Ala  Ile Val Arg 
    1130                 1135                 1140             


Leu Glu  Gln Leu Ala Pro Leu  Pro Arg Arg Arg Leu  Arg Glu Thr 
    1145                 1150                 1155             


Leu Asp  Arg Tyr Glu Asn Val  Lys Glu Phe Phe Trp  Val Gln Glu 
    1160                 1165                 1170             


Glu Pro  Ala Asn Gln Gly Ala  Trp Pro Arg Phe Gly  Leu Glu Leu 
    1175                 1180                 1185             


Pro Glu  Leu Leu Pro Asp Lys  Leu Ala Gly Ile Lys  Arg Ile Ser 
    1190                 1195                 1200             


Arg Arg  Ala Met Ser Ala Pro  Ser Ser Gly Ser Ser  Lys Val His 
    1205                 1210                 1215             


Ala Val  Glu Gln Gln Glu Ile  Leu Asp Glu Ala Phe  Gly 
    1220                 1225                 1230     


<210>  122
<211>  3696
<212>  DNA
<213>  Artificial

<220>
<223>  Mycobacterium tuberculosis  -ketoglutarate decarboxylase Kgd 
       codon optimised gene

<400>  122
atggctaata tctcctctcc gtttggtcag aatgaatggc tggtagaaga aatgtaccgt     60

aaattccgcg atgacccgtc ctctgtggac ccgtcctggc atgaattcct ggtagactac    120

agcccggagc cgaccagcca accggcagcg gaaccaaccc gcgttacttc tccgctggta    180

gcggaacgtg cagctgctgc cgcgcctcag gcgccgccta aaccggcgga tactgccgca    240

gccggtaacg gtgtggtggc cgcactggct gctaagactg cggttccgcc gccagcagaa    300

ggcgatgaag ttgcagtcct gcgcggtgcg gcggctgcag tggtgaaaaa catgagcgcg    360

tccctggagg taccgaccgc cacgagcgtg cgcgcggtcc ctgctaaact gctgattgat    420

aaccgtattg tgatcaacaa ccagctgaaa cgtacccgtg gtggcaagat ctccttcact    480

catctgctgg gttatgcact ggtacaagcg gttaagaaat tccctaacat gaaccgtcat    540

tacactgagg tcgacggtaa accgacggct gttactccgg cacacacgaa cctgggcctg    600

gcgatcgacc tgcaaggtaa agatggtaag cgctccctgg tagttgcggg tattaaacgt    660

tgcgaaacca tgcgtttcgc acaattcgta accgcctacg aggacattgt ccgccgtgct    720

cgtgatggca aactgaccac cgaagatttt gcgggcgtta ctattagcct gaccaaccca    780

ggcaccatcg gcaccgtgca cagcgtacct cgtctgatgc cgggccaagg tgcgattatc    840

ggtgtgggtg ccatggagta cccggcagaa tttcagggtg cttctgaaga gcgcatcgcc    900

gagctgggta ttggtaaact gatcaccctg acttctacct atgaccaccg catcattcag    960

ggcgcagaat ccggtgactt cctgcgcact attcacgaac tgctgctgtc cgacggtttc   1020

tgggatgaag tttttcgtga actgagcatc ccatatctgc cagttcgctg gtccaccgac   1080

aatccggact ctatcgttga caaaaacgct cgcgtaatga acctgatcgc tgcttatcgt   1140

aatcgtggtc acctgatggc tgatacggat ccgctgcgcc tggataaagc tcgtttccgt   1200

tcccacccgg acctggaagt gctgacccat ggtctgactc tgtgggatct ggaccgcgtg   1260

ttcaaagtag atggtttcgc gggtgctcag tacaagaagc tgcgtgacgt gctgggtctg   1320

ctgcgtgatg cgtactgtcg tcacattggt gtggagtacg cccacattct ggatccggaa   1380

cagaaagaat ggctggagca gcgtgtcgag accaaacacg taaaaccgac cgtagcgcag   1440

cagaaatata tcctgtccaa actgaacgcc gccgaggctt tcgaaacttt cctgcagacc   1500

aagtacgtgg gccagaaacg cttcagcctg gagggtgcgg aaagcgttat tccgatgatg   1560

gatgcagcta tcgatcagtg cgcggaacat ggtctggatg aagtcgttat cggtatgccg   1620

caccgtggtc gcctgaacgt actggcaaac atcgtcggta aaccatattc tcagatcttc   1680

acggaattcg agggcaacct gaacccgtcc caagcccacg gctccggcga cgtaaaatat   1740

catctgggtg ctaccggcct gtatctgcag atgttcggtg ataacgacat ccaggtatct   1800

ctgactgcta acccgagcca cctggaggcg gttgatcctg ttctggaagg tctggttcgc   1860

gccaaacagg atctgctgga ccacggctct atcgacagcg atggccagcg tgcattcagc   1920

gttgtaccgc tgatgctgca tggcgacgcg gcgttcgccg gtcagggtgt cgtagcagaa   1980

actctgaacc tggcgaacct gcctggctat cgcgtgggtg gcaccattca catcatcgtt   2040

aacaaccaaa tcggtttcac cacggcaccg gagtatagcc gttctagcga atattgcacc   2100

gacgtagcca aaatgatcgg tgcgccgatc ttccatgtaa acggtgacga tccagaggcc   2160

tgcgtgtggg tggctcgtct ggccgtagac ttccgccagc gttttaagaa agatgtggtt   2220

atcgacatgc tgtgctaccg ccgtcgtggt cacaacgaag gtgatgatcc gtctatgact   2280

aacccgtatg tctatgacgt ggtggacacc aagcgtggtg cacgcaaatc ttacacggag   2340

gccctgatcg gtcgtggcga catctctatg aaagaagcgg aagacgctct gcgtgattac   2400

cagggtcagc tggaacgtgt gttcaatgag gtgcgtgagc tggaaaagca cggcgtacaa   2460

ccgtccgaat ccgtagagtc cgatcagatg atccctgctg gtctggcaac tgctgttgat   2520

aaaagcctgc tggcgcgtat cggcgacgca ttcctggcgc tgccgaatgg ctttaccgcg   2580

cacccgcgcg tacagccggt actggaaaaa cgtcgtgaaa tggcctacga aggtaaaatc   2640

gattgggcct tcggtgagct gctggccctg ggctctctgg tggctgaggg caagctggta   2700

cgcctgagcg gccaggactc ccgtcgcggc actttttctc agcgtcacag cgtcctgatc   2760

gatcgtcaca ccggcgaaga attcacgccg ctgcaactgc tggctactaa ctccgatggt   2820

agcccgaccg gtggtaagtt cctggtgtac gattccccgc tgtccgaata tgctgcagtt   2880

ggtttcgagt atggttacac cgttggcaac ccggacgcag tggttctgtg ggaagcgcag   2940

ttcggcgatt tcgttaacgg tgcccagtcc attatcgatg agtttattag cagcggcgag   3000

gccaaatggg gccagctgtc taacgttgtg ctgctgctgc ctcacggcca cgagggtcaa   3060

ggcccggacc acacctccgc ccgtatcgaa cgcttcctgc agctgtgggc tgaaggctct   3120

atgaccatcg cgatgccgtc taccccaagc aactacttcc acctgctgcg tcgccacgca   3180

ctggacggca ttcagcgccc gctgatcgtt ttcaccccaa aatccatgct gcgccacaaa   3240

gcagctgttt ctgaaatcaa agattttacg gaaattaaat tccgttctgt gctggaagaa   3300

ccaacctacg aagacggtat tggcgaccgc aacaaggtaa gccgtatcct gctgacctcc   3360

ggcaaactgt actacgagct ggcagcacgt aaggcaaaag ataaccgcaa cgacctggcc   3420

atcgtccgcc tggaacagct ggcgccactg ccacgccgtc gcctgcgtga aaccctggat   3480

cgctacgaaa acgtaaaaga attcttctgg gtgcaggaag aaccggcaaa ccagggtgcg   3540

tggccgcgct ttggtctgga actgccggaa ctgctgccgg ataaactggc aggtatcaag   3600

cgcatcagcc gtcgcgctat gagcgccccg tcttctggta gctctaaagt acacgctgta   3660

gaacagcaag agatcctgga tgaggccttc ggctaa                             3696


<210>  123
<211>  74
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for amplification of Bacillus subtilis 
       aminotransferase x

<400>  123
ggggacaagt ttgtacaaaa aagcaggcta ggaggaatta accatgaagg ttttagtcaa     60

tggccggctg attg                                                       74


<210>  124
<211>  62
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for amplification of Bacillus subtilis 
       aminotransferase x

<400>  124
ggggaccact ttgtacaaga aagctgggtt tatgaaatgc tagcagcctg ttgaatgctt     60

tc                                                                    62


<210>  125
<211>  82
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for amplification of Bacillus subtilis 
       aminotransferase y

<400>  125
ggggacaagt ttgtacaaaa aagcaggcta ggaggaatta accatgactc atgatttgat     60

agaaaaaagt aaaaagcacc tc                                              82


<210>  126
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for amplification of Bacillus subtilis 
       aminotransferase y

<400>  126
ggggaccact ttgtacaaga aagctgggtt caatcttcaa ggctcgtaac ctcgtgg        57


<210>  127
<211>  64
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for amplification of Rhodobacter sphaeroides 
       aminotransferase

<400>  127
ggggacaagt ttgtacaaaa aagcaggcta ggaggaatta accatgcccg gttgcggggg     60

cttg                                                                  64


<210>  128
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for amplification of Rhodobacter sphaeroides 
       aminotransferase

<400>  128
ggggaccact ttgtacaaga aagctgggtt cagacggcgg ccggttcttt c              51


<210>  129
<211>  78
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for amplification of Legionella pneumophila 
       aminotransferase

<400>  129
ggggacaagt ttgtacaaaa aagcaggcta ggaggaatta accatgagta tcgcatttgt     60

taacggcaag tattgttg                                                   78


<210>  130
<211>  67
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for amplification of Legionella pneumophila 
       aminotransferase

<400>  130
ggggaccact ttgtacaaga aagctgggtt tagtttacta gttgttggta ggaatcatta     60

attatcc                                                               67


<210>  131
<211>  76
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for amplification of Nitrosomonas europaea 
       aminotransferase

<400>  131
ggggacaagt ttgtacaaaa aagcaggcta ggaggaatta accatgattt acctcaatgg     60

caaatttctg ccgatg                                                     76


<210>  132
<211>  50
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for amplification of Nitrosomonas europaea 
       aminotransferase

<400>  132
ggggaccact ttgtacaaga aagctgggtt tactggcgtg gagcatgccc                50


<210>  133
<211>  79
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for amplification of Neisseria gonorrhoeae 
       aminotransferase

<400>  133
ggggacaagt ttgtacaaaa aagcaggcta ggaggaatta accatgagga taaatatgaa     60

ccgtaacgaa attttattc                                                  79


<210>  134
<211>  56
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for amplification of Neisseria gonorrhoeae 
       aminotransferase

<400>  134
ggggaccact ttgtacaaga aagctgggtt catgcagcca tcgccttgaa cacttc         56


<210>  135
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for amplification of Pseudomonas aeruginosa 
       aminotransferase

<400>  135
ggggacaagt ttgtacaaaa aagcaggcta ggaggaatta accatgtcga tggccgatcg     60

tgatgg                                                                66


<210>  136
<211>  53
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for amplification of Pseudomonas aeruginosa 
       aminotransferase

<400>  136
ggggaccact ttgtacaaga aagctgggtt tacttgacca gggtacgcca ctc            53


<210>  137
<211>  67
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for amplification of Rhodopseudomonas palustris 
       aminotransferase

<400>  137
ggggacaagt ttgtacaaaa aagcaggcta ggaggaatta accatgaagc tgataccgtg     60

ccgcgcc                                                               67


<210>  138
<211>  51
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for amplification of Rhodopseudomonas palustris 
       aminotransferase

<400>  138
ggggaccact ttgtacaaga aagctgggtt caggcgaccg cgcggatcac c              51


<210>  139
<211>  71
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for amplification of Bacillus subtilis 
       aminotransferase (gi16077991)

<400>  139
ggggacaagt ttgtacaaaa aagcaggcta ggaggaatta accatggaga tgatggggat     60

ggaaaacatt c                                                          71


<210>  140
<211>  65
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for amplification of Bacillus subtilis 
       aminotransferase (gi16077991)

<400>  140
ggggaccact ttgtacaaga aagctgggtt tatatcgttt gaaagctttc tttcaccgtt     60

ttcac                                                                 65


<210>  141
<211>  66
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for amplification of Pseudomonas aeruginosa 
       aminotransferase (gi9951072)

<400>  141
ggggacaagt ttgtacaaaa aagcaggcta ggaggaatta accatgaacg caagactgca     60

cgccac                                                                66


<210>  142
<211>  48
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for amplification of Pseudomonas aeruginosa 
       aminotransferase (gi9951072)

<400>  142
ggggaccact ttgtacaaga aagctgggtt taccggtgac cggcgcgg                  48


<210>  143
<211>  69
<212>  DNA
<213>  Artificial

<220>
<223>  Forward primer for amplification of Pseudomonas aeruginosa 
       aminotransferase (gi9951630)

<400>  143
ggggacaagt ttgtacaaaa aagcaggcta ggaggaatta accatgacaa tgaatgacga     60

gccgcagtc                                                             69


<210>  144
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  Reverse primer for amplification of Pseudomonas aeruginosa 
       aminotransferase (gi9951630)

<400>  144
ggggaccact ttgtacaaga aagctgggtt cagacgctgg cgcggatgg                 49


<210>  145
<211>  1221
<212>  DNA
<213>  Methanococcus jannaschii

<400>  145
atgacaaaag tgctggtgat gtttatggat ttcttatttg agaacagctg gaaagcagtt     60

tgtccctaca atccaaagtt ggatttaaag gacatttata tttatgacac aaccctaaga    120

gatggagagc aaaccccagg agtttgcttt accaaagaac aaaaattgga gattgcaagg    180

aagttggatg aacttggatt aaagcagatt gaagctggct tcccaatagt atctgaaaga    240

gaagcagata tagttaaaac aattgctaat gaagggctaa atgctgatat cttagcttta    300

tgcagggctt taaagaaaga tatagataaa gcaatagagt gcgatgtaga tgggattatt    360

accttcatag caacatctcc tctccactta aaatataaat tcaacaacaa aagcttagat    420

gaaatattag agatgggagt tgaggcagtt gagtatgcaa aggaacatgg cttatttgtt    480

gctttctctg cagaggatgc gacaagaaca ccaatagagg acttgattaa agtgcataaa    540

gccgctgaag aggctggagc agatagggtt catatagcag acacaactgg ctgtgctacc    600

ccccaaagta tggagtttat atgtaaaaca ttgaaggaga acttaaaaaa ggcacatatt    660

ggagtgcatt gtcacaacga ctttggattt gcagttataa attcaatata tggtttaatt    720

ggaggagcta aggcagtttc aacaacagtt aatggtattg gagagagggc agggaatgca    780

gctttagaag agctaattat ggctttaact gtcttgtatg atgttgattt gggattaaac    840

ttggaggttc ttccagagtt atgcagaatg gttgaggaat actctggaat aaagatgcca    900

aagaacaaac caatagttgg agagcttgta tttgctcatg aaagtggaat tcacgttgat    960

gctgtcatag agaatccatt aacctatgaa cccttccttc cagagaaaat agggcttaag   1020

agaaatattt tgttagggaa gcattctgga tgcagagccg ttgcctataa gctaaaactt   1080

atgggaattg attacgatag agagatgttg tgcgagattg ttaaaaaggt taaagagatt   1140

agagaggaag gtaaatttat aactgatgaa gtctttaagg agattgttga agaagtttta   1200

aggaagagaa ataaaaatta a                                             1221


<210>  146
<211>  513
<212>  DNA
<213>  Methanococcus jannaschii

<400>  146
atgattatta agggaagagc tcacaaattt ggggatgatg tagatacaga cgcaataatt     60

ccaggacctt acttaaggac tacagaccct tacgagttag cttcacactg catggcaggg    120

atagatgaaa acttcccgaa aaaggttaag gagggggatg tgatagttgc tggagagaat    180

tttggttgtg gttcaagtag ggagcaggct gtaatagcaa taaaatactg tggtattaag    240

gctgtgatag caaaaagctt tgcaagaata ttctatagaa atgcaataaa cgttggatta    300

ataccaataa tagcaaatac agatgaaatt aaagacggag acatagtaga gattgattta    360

gataaagaag agattgtaat aaccaataaa aacaaaacaa taaagtgtga aacaccaaaa    420

ggtttagaaa gagaaatatt ggctgctggt ggcttagtca attatttaaa aaagagaaaa    480

ctaatacaat caaaaaaagg tgtaaaaaca tga                                 513


<210>  147
<211>  1263
<212>  DNA
<213>  Methanococcus jannaschii

<400>  147
ttgacattgg tagagaagat actatcaaaa aaagttggtt atgaagtttg tgcaggagat     60

agcatagagg ttgaagttga tttggcaatg acacacgatg gaacaacacc tttagcatac    120

aaagctttaa aggaaatgag tgatagtgtt tggaatccag ataaaatagt cgttgccttt    180

gaccacaatg ttccaccaaa cacagttaaa gctgctgaaa tgcaaaaatt agctttggag    240

tttgttaaaa gatttggcat taaaaatttc cataaaggtg gagaaggcat ctgtcatcaa    300

atcttagctg aaaattatgt tttgccaaac atgtttgtag ctggtggaga cagccataca    360

tgcacacatg gagcttttgg agcttttgct actggctttg gagctactga tatggcttac    420

atctatgcaa caggagaaac atggattaaa gtgccaaaaa caattagggt agatatagtt    480

ggaaaaaatg aaaatgtttc tgccaaagat attgttttaa gggtttgtaa ggaaattggg    540

agaagaggag caacatacat ggctattgag tatggtggag aggttgttaa aaacatggac    600

atggatggaa ggctaacttt atgcaacatg gcaatagaga tgggaggaaa aacaggagtg    660

atagaggctg atgaaattac ttatgattat ttaaagaaag agagaggact ttctgatgag    720

gatatagcta aattaaaaaa agagagaata acagtaaata gagatgaagc aaactactat    780

aaggagatag aaattgacat aacagatatg gaagaacaag ttgctgttcc acaccaccca    840

gataacgtaa agccaattag tgatgttgaa gggactgaga taaatcaagt ttttattggg    900

agttgcacaa atggaaggtt gagtgattta agagaagcag ctaaatattt aaaaggtagg    960

gaggttcata aagatgttaa gctaattgtt atcccggcat caaaaaaggt atttttgcaa   1020

gcgttaaaag agggtattat agatatcttt gttaaagctg gggcgatgat ttgcactccg   1080

ggatgcggac cttgcttagg agctcatcaa ggggttttgg ctgagggaga aatttgttta   1140

tcaacaacaa acagaaactt taaaggaagg atggggcata taaatagcta tatttacttg   1200

gcatctccaa agattgccgc aataagtgca gttaagggat atataaccaa caaattggat   1260

taa                                                                 1263


<210>  148
<211>  1044
<212>  DNA
<213>  Methanococcus jannaschii

<400>  148
atgatgaagg tgtgtgttat agaaggggat ggaataggaa aagaagtgat tccagaggcc     60

ataaaaatat taaatgagtt gggagagttt gaaataataa aaggagaggc aggattagaa    120

tgtttaaaaa aatatggtaa tgcacttcca gaggatacaa tagaaaaagc taaagaggca    180

gatattattt tgtttggggc tataacctca ccaaagccag gggaagttca aaattataaa    240

agccctataa taacgttgag gaagatgttt catttatatg caaatgtaag accaataaac    300

aactttggaa ttggacaatt aattgggaaa attgcagatt atgaattctt aaatgctaag    360

aatattgata tagttattat aagagagaat acggaagatt tatatgttgg tagagagaga    420

ttagaaaatg atacagcaat agctgagagg gttataacaa gaaagggtag cgagagaata    480

ataagatttg catttgaata tgctataaaa aataatagga aaaaggtatc ttgcatccat    540

aaagctaatg ttttaagaat aactgatggt ttattcttag aggtttttaa tgaaataaaa    600

aaacattata atatagaggc agatgattat ttagttgatt caacagctat gaacttaata    660

aaacatcctg aaaaatttga tgttattgtt acaacaaaca tgtttgggga tattttatca    720

gatgaggcat ctgcattaat tggaggactt ggtttagctc cttcagcaaa tataggagat    780

gataaagcat tatttgagcc agttcatggt tcagctccag atatagctgg gaaaggtata    840

gcaaatccaa tggcatctat attaagtatt gctatgcttt ttgattatat tggagagaaa    900

gaaaagggag atttgattag agaggcagtg aaatactgct taataaacaa aaaagttact    960

cctgacttgg gaggggattt aaagacaaaa gatgttggag acgaaattct aaattacatt   1020

agaaagaagt taaagggata ttga                                          1044


<210>  149
<211>  1155
<212>  DNA
<213>  Azotobacter vinelandii

<400>  149
atggctagcg tgatcatcga cgacactacc ctgcgtgacg gtgaacagag tgccggggtc     60

gccttcaatg ccgacgagaa gatcgctatc gcccgcgcgc tcgccgaact gggcgtgccg    120

gagttggaga tcggcattcc cagcatgggc gaggaagagc gcgaggtgat gcacgccatc    180

gccggtctcg gcctgtcgtc tcgcctgctg gcctggtgcc ggctatgcga cgtcgatctc    240

gcggcggcgc gctccaccgg ggtgaccatg gtcgaccttt cgctgccggt ctccgacctg    300

atgctgcacc acaagctcaa tcgcgatcgc gactgggcct tgcgcgaagt ggccaggctg    360

gtcggcgaag cgcgcatggc cgggctcgag gtgtgcctgg gctgcgagga cgcctcgcgg    420

gcggatctgg agttcgtcgt gcaggtgggc gaagtggcgc aggccgccgg cgcccgtcgg    480

ctgcgcttcg ccgacaccgt cggggtcatg gagcccttcg gcatgctcga ccgcttccgt    540

ttcctcagcc ggcgcctgga catggagctg gaagtgcacg cccacgatga tttcgggctg    600

gccacggcca acaccctggc cgcggtgatg ggcggggcga ctcatatcaa caccacggtc    660

aacgggctcg gcgagcgtgc cggcaacgcc gcgctggaag agtgcgtgct ggcgctcaag    720

aacctccacg gtatcgacac cggtatcgat acccgcggca tcccggccat ctccgcgctg    780

gtcgagcggg cctcggggcg ccaggtggcc tggcagaaga gcgtggtcgg cgccggggtg    840

ttcactcacg aggccggtat ccacgtcgac ggactgctca agcatcggcg caactacgag    900

gggctgaatc ccgacgaact cggtcgcagc cacagtctgg tgctgggcaa gcattccggg    960

gcgcacatgg tgcgcaacac gtaccgcgat ctgggtatcg agctggcgga ctggcagagc   1020

caagcgctgc tcggccgcat ccgtgccttc tccaccagga ccaagcgcag cccgcagcct   1080

gccgagctgc aggatttcta tcggcagttg tgcgagcaag gcaatcccga actggccgca   1140

ggaggaatgg catga                                                    1155


<210>  150
<211>  30
<212>  DNA
<213>  Artificial

<220>
<223>  Avine-WT-R-BamHI

<400>  150
aaattggatc ctcatgccat tcctcctgcg                                      30


<210>  151
<211>  75
<212>  DNA
<213>  Artificial

<220>
<223>  Avine-WT-F-SacI

<400>  151
aaattgagct ctttctccat acccgttttt ttgggctaac aggaggaatt aaccatggct     60

agcgtgatca tcgac                                                      75


<210>  152
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  Avine-WT-R-HindIII

<400>  152
aaattaaagc tttcatgcca ttcctcctgc g                                    31


<210>  153
<211>  76
<212>  DNA
<213>  Artificial

<220>
<223>  Avine-WT-F-HindIII

<400>  153
aaattaaagc tttttctcca tacccgtttt tttgggctaa caggaggaat taaccatggc     60

tagcgtgatc atcgac                                                     76


<210>  154
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  AksA-Avine-F

<400>  154
atggctagcg tgatcatcga c                                               21


<210>  155
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  AksA-Avine-R1

<400>  155
aaattggcgc gcctcatgcc attcctcctg cg                                   32


<210>  156
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  Pgal2-F2

<400>  156
aaattgttaa ctccagaagg cacatctatt ac                                   32


<210>  157
<211>  49
<212>  DNA
<213>  Artificial

<220>
<223>  Pgal2-R

<400>  157
cgtcgatgat cacgctagcc attatgaaag cctccttttt tttattatg                 49


<210>  158
<211>  207
<212>  DNA
<213>  Artificial

<220>
<223>  mtSP

<400>  158
atggcctcca ctcgtgtcct cgcctctcgc ctggcctccc agatggctgc ttccgccaag     60

gttgcccgcc ctgctgtccg cgttgctcag gtcagcaagc gcaccatcca gactggctcc    120

cccctccaga ccctcaagcg cacccagatg acctccatcg tcaacgccac cacccgccag    180

gctttccaga agcgcgccta ctcttcc                                        207


<210>  159
<211>  29
<212>  DNA
<213>  Artificial

<220>
<223>  pF113-F-NsiI

<400>  159
aaattatgca tacagcatgg cctgcaacg                                       29


<210>  160
<211>  31
<212>  DNA
<213>  Artificial

<220>
<223>  pF113-R-AgeI

<400>  160
aaattaccgg tcagggttat tgtctcatga g                                    31


<210>  161
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  AT-Vfl_for_Ec

<400>  161
aaatttggta ccgctaggag gaattaacca tg                                   32


<210>  162
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  Kdc_for_Ec

<400>  162
aaatttacta gtggctagga ggaattacat atg                                  33


<210>  163
<211>  35
<212>  DNA
<213>  Artificial

<220>
<223>  Kdc_rev_Ec

<400>  163
aaatttaagc ttattacttg ttctgctccg caaac                                35


<210>  164
<211>  57
<212>  DNA
<213>  Artificial

<220>
<223>  AT-Vfl-F

<400>  164
aaatttacta gtaagaattt ttgaggaggc aatataaatg aataaaccac agtcttg        57


<210>  165
<211>  32
<212>  DNA
<213>  Artificial

<220>
<223>  AT-Vfl-R

<400>  165
aaatttggat cctacaagaa agctgggttt ac                                   32


<210>  166
<211>  33
<212>  DNA
<213>  Artificial

<220>
<223>  AT-Vfl_rev_Ec

<400>  166
aaatttacta gtaagctggg tttacgcgac ttc                                  33


<210>  167
<211>  1221
<212>  DNA
<213>  Escherichia coli

<400>  167
atgaccaaag ttctggtaat gttcatggac ttcctgttcg aaaactcctg gaaagcggtt     60

tgcccgtaca acccgaaact ggatctgaaa gacatctaca tctacgacac cactctgcgt    120

gacggtgaac agactccggg cgtttgcttc accaaagagc agaagctgga aatcgctcgt    180

aagctggacg aactgggtct gaagcagatc gaagctggct tcccgatcgt ttctgaacgt    240

gaagctgaca tcgttaaaac tatcgctaac gaaggtctga acgctgacat cctggcactg    300

tgccgtgcgc tgaagaaaga catcgacaaa gcaatcgaat gcgacgttga cggtatcatc    360

actttcatcg caacttctcc gctgcacctg aaatacaaat tcaacaacaa atctctggat    420

gaaatcctgg aaatgggcgt tgaagcggta gaatacgcta aagagcacgg tctgttcgtt    480

gcattctctg cagaagatgc aactcgtact ccgatcgaag atctgatcaa agttcacaaa    540

gcagctgaag aagcgggtgc tgaccgcgtt cacatcgctg acaccactgg ctgcgcaact    600

ccgcagtcta tggaattcat ctgcaaaact ctgaaagaaa acctgaagaa agcacacatc    660

ggcgtacact gccacaacga cttcggtttc gctgttatca actccatcta cggtctgatc    720

ggtggtgcga aagcggtatc tactaccgtt aacggtatcg gtgaacgtgc tggtaacgct    780

gcactggaag agctgatcat ggcgctgacc gtactgtacg acgttgacct gggtctgaac    840

ctggaagttc tgccggaact gtgccgtatg gttgaagaat actccggtat caagatgccg    900

aaaaacaagc caatcgttgg tgaactggta ttcgctcacg aatccggtat ccacgttgac    960

gctgttatcg aaaacccgct gacttacgaa ccgttcctgc cggaaaaaat cggtctgaaa   1020

cgtaacatcc tgctgggtaa gcactctggt tgccgtgctg ttgcttacaa gctgaaactg   1080

atgggtatcg actacgaccg tgaaatgctg tgcgaaatcg ttaagaaagt taaagaaatc   1140

cgtgaagaag gtaaattcat cactgacgaa gttttcaaag agatcgttga agaagttctg   1200

cgtaagcgta acaaaaacta a                                             1221


<210>  168
<211>  1044
<212>  DNA
<213>  Escherichia coli

<400>  168
atgatgaaag tttgcgttat cgaaggtgac ggtatcggta aagaagttat cccggaagct     60

atcaagatcc tgaacgaact gggtgaattc gaaatcatca aaggtgaagc gggtctggaa    120

tgcctgaaga aatacggtaa cgcactgcca gaagatacca tcgaaaaagc gaaagaagct    180

gacatcatcc tgttcggtgc aatcacttct ccgaagccgg gtgaagttca gaactacaaa    240

tctccgatca tcactctgcg taagatgttc cacctgtacg ctaacgtacg tccgatcaac    300

aacttcggta tcggtcagct gatcggtaag atcgctgact acgagttcct gaacgctaaa    360

aacatcgaca tcgttatcat ccgtgaaaac actgaagatc tgtacgttgg tcgtgaacgt    420

ctggaaaacg acactgctat cgctgagcgc gttatcactc gtaaaggttc tgaacgtatc    480

atccgcttcg cattcgaata cgcaatcaaa aacaaccgta agaaagtttc ctgcatccac    540

aaagctaacg tactgcgtat cactgacggt ctgttcctgg aagtattcaa cgaaatcaag    600

aaacactaca acatcgaagc tgacgactac ctggttgact ccactgcaat gaacctgatc    660

aagcacccgg aaaaattcga cgttatcgtt accactaaca tgttcggtga catcctgtct    720

gacgaagcgt ctgcactgat cggtggtctg ggtctggcac cgtctgctaa catcggtgac    780

gacaaagcgc tgttcgaacc ggttcacggt tctgcaccgg atatcgctgg taaaggtatc    840

gctaacccga tggcttctat cctgtctatc gcgatgctgt tcgactacat cggtgaaaaa    900

gagaaaggcg acctgatccg tgaagcggta aaatactgcc tgatcaacaa gaaagttact    960

ccggatctgg gtggtgacct gaaaaccaaa gacgttggtg acgaaatcct gaactacatc   1020

cgtaagaaac tgaaaggtta ctaa                                          1044


<210>  169
<211>  1263
<212>  DNA
<213>  Escherichia coli

<400>  169
atgactctgg ttgagaagat cctctccaag aaagttggtt acgaagtttg cgcaggcgac     60

tccatcgaag ttgaagttga cctggcgatg actcacgacg gtactactcc gctggcttac    120

aaagcgctga aagagatgtc tgactccgta tggaacccgg acaagatcgt tgttgcattc    180

gaccacaacg taccgccgaa caccgttaaa gcagctgaaa tgcagaagct ggcgctggaa    240

ttcgttaagc gcttcggtat caaaaacttc cacaaaggtg gtgaaggtat ctgccaccag    300

atcctggctg aaaactacgt tctgccgaac atgttcgttg ctggcggcga ctctcacacc    360

tgtactcacg gtgcattcgg tgcattcgca actggcttcg gtgcaactga catggcttac    420

atctacgcaa ctggcgaaac ctggatcaaa gttccgaaaa ctatccgcgt tgatatcgtt    480

ggtaaaaacg aaaacgtatc tgcgaaagac atcgttctgc gcgtttgcaa agaaatcggt    540

cgtcgcggtg caacttacat ggctatcgaa tacggtggtg aagttgttaa aaacatggac    600

atggacggtc gtctgactct gtgcaacatg gctatcgaaa tgggtggtaa aactggcgtt    660

atcgaagctg acgaaatcac ttacgactac ctgaagaaag agcgtggtct gtctgacgaa    720

gatatcgcta aactgaagaa agagcgtatc accgttaacc gtgacgaagc taactactac    780

aaagaaatcg aaatcgacat cactgacatg gaagaacagg ttgctgtacc gcaccacccg    840

gataacgtta agccaatctc tgacgttgaa ggtactgaaa tcaaccaggt attcatcggt    900

tcctgcacca acggtcgtct gtctgatctg cgtgaagctg cgaaatacct gaaaggtcgt    960

gaagttcaca aagacgttaa gctgatcgtt atcccggctt ccaagaaagt attcctgcag   1020

gcgctgaaag aaggtatcat cgacatcttc gttaaagcgg gtgcgatgat ctgtactccg   1080

ggttgcggtc cgtgcctggg tgcacaccag ggcgtactgg cagaaggtga aatctgcctg   1140

tctactacca accgtaactt caaaggtcgt atgggtcaca tcaactctta catctacctg   1200

gcttctccga aaatcgctgc tatctctgct gttaaaggtt acatcactaa caagctggat   1260

taa                                                                 1263


<210>  170
<211>  513
<212>  DNA
<213>  Escherichia coli

<400>  170
atgatcatca aaggtcgtgc gcacaagttc ggtgacgacg ttgacactga cgctatcatc     60

ccaggtccgt acctccgtac tactgacccg tacgaactgg catctcactg catggcgggt    120

atcgacgaaa acttcccgaa gaaagttaaa gaaggtgacg ttatcgttgc tggcgaaaac    180

ttcggttgcg gttcttcccg tgagcaggct gttatcgcta tcaaatactg cggtatcaaa    240

gcggttatcg ctaaatcttt cgcacgtatc ttctaccgta acgcaatcaa cgtaggtctg    300

atcccgatca tcgctaacac cgacgaaatc aaagacggtg acatcgttga aatcgacctg    360

gataaagaag aaatcgttat cactaacaaa aacaaaacta tcaagtgcga aactccgaaa    420

ggtctggaac gtgaaatcct ggcagctggc ggtctggtta actacctgaa gaaacgtaag    480

ctgattcagt ccaagaaagg cgtaaaaact taa                                 513


<210>  171
<211>  1221
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  171
atgaccaagg ttttggtcat gttcatggac ttcttgtttg aaaactcctg gaaggccgtt     60

tgtccataca acccaaagtt ggacttgaag gacatctaca tctacgacac cactttaaga    120

gatggtgaac aaaccccagg tgtttgtttc accaaggaac aaaaattgga aattgccaga    180

aagttggacg aattgggttt gaaacaaatc gaagctggtt tcccaatcgt ttctgaaaga    240

gaagctgaca ttgtcaagac cattgccaac gaaggtttga acgctgatat cttagctcta    300

tgtagagctt tgaagaagga cattgacaag gccatcgaat gtgatgtcga tggtatcatc    360

actttcattg ctacttctcc attacatttg aaatacaagt tcaacaacaa atctttggac    420

gaaatcttgg aaatgggtgt tgaagctgtc gaatacgcca aggaacacgg tttattcgtt    480

gctttctctg ctgaagatgc taccagaact ccaattgaag atttgatcaa ggtccacaag    540

gctgctgaag aagctggtgc tgaccgtgtc cacattgctg acaccactgg ttgtgccact    600

ccacaatcca tggaatttat ctgtaagact ttgaaggaaa acttgaagaa ggctcacatt    660

ggtgttcact gtcacaacga tttcggtttc gctgtcatca actccatcta cggtttgatt    720

ggtggtgcca aggccgtttc caccaccgtc aacggtatcg gtgaaagagc tggtaacgct    780

gctttggaag aattgatcat ggctttgact gtcttatacg atgtcgattt gggtttgaac    840

ttggaagttt tgccagaatt gtgtagaatg gttgaagaat actctggtat caagatgcca    900

aagaacaagc caattgtcgg tgaattggtt ttcgctcatg aatctggtat tcacgttgac    960

gctgtcattg aaaacccatt gacctacgaa cctttcttgc cagaaaagat cggtttgaag   1020

agaaacatcc tattaggtaa gcactctggt tgtcgtgctg ttgcttacaa attgaaattg   1080

atgggtattg actacgacag agaaatgttg tgtgaaattg tcaagaaggt caaggaaatc   1140

agagaagaag gtaagttcat cactgacgaa gttttcaagg aaatcgttga agaagttttg   1200

agaaagagaa acaaaaatta a                                             1221


<210>  172
<211>  1263
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  172
atgactttag tcgaaaagat cttatccaag aaggtcggtt acgaagtttg tgccggtgac     60

tctattgaag ttgaagttga cttggccatg acccacgacg gtactacccc attggcttac    120

aaggctttga aggaaatgtc tgactccgtc tggaacccag acaagattgt tgttgctttc    180

gaccacaacg ttccaccaaa caccgtcaag gctgctgaaa tgcaaaaatt ggctttggaa    240

tttgtcaaga gattcggtat caagaacttc cacaagggtg gtgaaggtat ctgtcaccaa    300

atcttggctg aaaactacgt tttgccaaac atgttcgttg ctggtggtga ctcccacact    360

tgtacccacg gtgctttcgg tgcctttgct accggtttcg gtgctactga catggcttac    420

atctacgcta ccggtgaaac ctggatcaag gttccaaaga ctatcagagt tgacattgtc    480

ggtaagaacg aaaacgtttc tgccaaggat atcgtcttga gagtttgtaa ggaaattggt    540

agaagaggtg ctacttacat ggccattgaa tacggtggtg aagttgtcaa gaacatggac    600

atggacggta gattgacttt gtgtaacatg gccattgaaa tgggtggtaa gactggtgtc    660

attgaagctg atgaaatcac ctacgactac ttgaagaagg aaagaggtct atccgatgaa    720

gatatcgcca aattgaagaa ggaaagaatc actgttaaca gagatgaagc taactactac    780

aaggaaattg aaattgatat cactgacatg gaagaacaag ttgctgttcc tcatcaccca    840

gacaatgtca agccaatttc tgacgtcgaa ggtactgaaa tcaaccaagt tttcatcggt    900

tcttgtacca acggtagatt atctgattta cgtgaagctg ctaagtactt gaaaggtcgt    960

gaagttcaca aggatgtcaa attgattgtc attccagctt ccaagaaggt tttcttgcaa   1020

gctttgaagg aaggtatcat cgatatcttc gtcaaggctg gtgccatgat ctgtacccca   1080

ggttgtggtc catgtttggg tgctcatcaa ggtgtcttgg ctgaaggtga aatctgtttg   1140

tccaccacca acagaaactt caagggtaga atgggtcaca tcaactctta catctacttg   1200

gcttctccaa agattgctgc catttctgct gtcaagggtt acatcactaa caaattggat   1260

taa                                                                 1263


<210>  173
<211>  513
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  173
atgatcatca agggtcgtgc tcacaagttc ggtgacgatg ttgacactga tgctatcatt     60

ccaggtccat acttgagaac cactgaccca tacgaattgg cttctcactg tatggctggt    120

attgacgaaa acttcccaaa gaaggtcaag gaaggtgatg tcattgttgc tggtgaaaac    180

tttggttgtg gttcttccag agaacaagct gttattgcca tcaaatactg tggtatcaag    240

gctgtcattg ccaagtcttt cgctagaatc ttctacagaa acgccatcaa cgttggtttg    300

attccaatca ttgctaacac tgacgaaatc aaggatggtg acattgttga aatcgatttg    360

gacaaggaag aaattgttat caccaacaag aacaagacca tcaagtgtga aactccaaag    420

ggtttggaaa gagaaatctt ggctgctggt ggtttagtca actacttgaa gaagagaaag    480

ttgatccaat ccaagaaggg tgtcaaaacc taa                                 513


<210>  174
<211>  1044
<212>  DNA
<213>  Saccharomyces cerevisiae

<400>  174
atgatgaagg tttgtgtcat tgaaggtgac ggtattggta aggaagtcat tccagaagct     60

atcaagatct tgaatgaatt gggtgaattt gaaatcatca agggtgaagc tggtttggaa    120

tgtttgaaga aatacggtaa cgctttgcca gaagatacca ttgaaaaggc caaggaagct    180

gatatcatct tattcggtgc catcacttct ccaaagccag gtgaagttca aaactacaaa    240

tctccaatca tcactttgag aaagatgttc cacttgtacg ctaacgtcag accaatcaac    300

aacttcggta ttggtcaatt gattggtaag attgctgact acgaattttt gaatgccaag    360

aacattgaca ttgtcatcat cagagaaaac actgaagatt tgtacgttgg tcgtgaaaga    420

ttagaaaacg acactgccat tgctgaacgt gttatcacca gaaagggttc tgaaagaatc    480

atcagattcg ctttcgaata cgccatcaag aacaacagaa agaaggtttc ctgtatccac    540

aaggctaacg ttttgagaat caccgatggt ttattcttgg aagttttcaa cgaaatcaag    600

aagcactaca acattgaagc tgatgactac ttggttgact ccactgctat gaacttgatc    660

aagcatccag aaaagttcga tgtcattgtc accaccaaca tgttcggtga catcttatct    720

gacgaagctt ctgctttgat tggtggtcta ggtttggctc catctgccaa cattggtgat    780

gacaaggctt tattcgaacc tgttcacggt tctgctccag acattgctgg taagggtatt    840

gccaacccaa tggcttccat cttgtccatt gctatgttgt tcgactacat cggtgaaaag    900

gaaaagggtg acttgatcag agaagctgtc aaatactgtt tgatcaacaa gaaggttact    960

ccagatttgg gtggtgactt gaaaaccaag gatgtcggtg acgaaatctt gaactacatc   1020

agaaagaaat tgaaaggcta ctaa                                          1044


<210>  175
<211>  52
<212>  DNA
<213>  Artificial

<220>
<223>  DC-KdcA-F

<400>  175
aaatttggat ccgttgagga ggcctcaaaa atgtatactg ttggtgatta tc             52


<210>  176
<211>  37
<212>  DNA
<213>  Artificial

<220>
<223>  DC-KdcA-R

<400>  176
aaatttggcg cgccattact tgttctgctc cgcaaac                              37


<210>  177
<211>  1161
<212>  DNA
<213>  Artificial

<220>
<223>  AksA E. coli codon optimised

<400>  177
atggactgga aagcggtatc tccgtacaac ccgaaactga acctgaaaga ctgctacctg     60

tacgacacca ctctgcgtga cggcgagcag actccgggcg tttgcttcac tcacgaccag    120

aaactggaaa tcgcgaagaa actggacgaa ctgaaaatca agcagatcga agctggcttc    180

ccgatcgttt ctgaaaacga acgtaaagca atcaagtcta tcaccggtga aggtctgaac    240

gctcagatcc tggcactctc tcgcgtactg aaagaagata tcgacaaagc aatcgaatgc    300

gacgttgacg gtatcatcac tttcatcgct gcttctccga tgcacctgaa atacaaactg    360

cacaaatctc tggatgaagt tgaagagatg ggtatgaaag cggtagaata cgctaaagac    420

cacggtctgt tcgttgcatt ctctgctgaa gatgcaactc gtactccggt tgaagatctg    480

atccgtatcc acaaaaacgc tgaagagcac ggtgctaacc gcgttcacat cgctgacact    540

ctgggttgcg caactccgca ggcaatgtac cacatctgct ctgaactgtc ctccaacctg    600

aagaaagcgc acatcggtgt tcactgccac aacgacttcg gtttcgctgt tatcaactcc    660

atctacggtc tgatcggtgg tgcgaaagcg gtatctacta ccgttaacgg tatcggtgaa    720

cgtgctggta acgctgctat cgaagaaatc gttatggcgc tgaaagttct gtacgaccac    780

gacatgggtc tgaacactga aatcctgact gaaatctcca agctggttga aaactactcc    840

aagatccgta tcccggaaaa caagccgctg gttggtgaaa tggcattcta ccacgaatcc    900

ggtatccacg ttgacgctgt tctggaaaac ccgctgactt acgaaccgtt cctgccagaa    960

aaaatcggtc agaagcgtaa gatcatcctg ggtaagcact ctggttgccg tgctgttgct   1020

caccgtctgc aggaactggg tctggaagca tctcgtgaag agctgtggga aatcgttaag   1080

aaaaccaaag aaactcgtga agaaggtact gaaatctctg acgaagtatt caaaaacatc   1140

gttgacaaaa tcattaaata a                                             1161


<210>  178
<211>  1020
<212>  DNA
<213>  Artificial

<220>
<223>  AksF E. coli codon optimised

<400>  178
atgcgtaaca ctccgaaaat ctgcgttatc aacggtgacg gtatcggtaa cgaagttatc     60

ccggaaaccg ttcgcgtact gaacgaaatc ggtgacttcg aattcatcga aactcacgct    120

ggttacgaat gcttcaagcg ctgcggtgac gctatcccgg aaaaaactat cgaaatcgct    180

aaagagtctg actccatcct gttcggttct gtaactactc cgaagccgac tgaactgaaa    240

aacaagccgt accgttctcc gattctgact ctgcgtaaag agctggatct gtacgctaac    300

atccgtccga ctttcaactt caaaaacctg gacttcgtta tcatccgtga aaacactgaa    360

ggtctgtacg ttaagaaaga atactacgac gaaaaaaacg aagttgcaac tgctgaacgt    420

atcatctcca aattcggttc ttcccgtatc gttaagttcg cattcgacta cgcactgcag    480

aacaaccgta agaaagtttc ctgcatccac aaagctaacg ttctgcgtat cactgacggt    540

ctgttcctgg gcgtattcga agaaatctcc aagaaatacg agaagctggg tatcgtttct    600

gacgactacc tgatcgacgc aactgcgatg tacctgatcc gtaacccgca gatgttcgac    660

gtaatggtta ccactaacct gttcggtgac atcctgtctg acgaagctgc tggtctgatc    720

ggtggtctgg gtatgtcccc gtctgctaac atcggtgaca aaaacggtct gttcgaaccg    780

gttcacggtt ctgcaccgga tatcgctggt aaaggtatct ccaacccaat cgcgactatc    840

ctgtctgctg caatgatgct ggatcacctg aaaatcaaca aagaagctga atacatccgt    900

aacgctgtta agaaaaccgt tgaatgtaaa tacctgactc cggacctggg tggtcacctg    960

aaaacttctg aagttactga aaaaatcatc gaatccatca aatctcagat gattcagtaa   1020


<210>  179
<211>  1257
<212>  DNA
<213>  Artificial

<220>
<223>  AksD E. coli codon optimised

<400>  179
atgactctgg ctgaaaaaat catctccaaa aacgttggta aaaacgttta cgctggcgac     60

tccgttgaaa tcgacgttga cgttgcgatg actcacgacg gtactactcc gctgaccgtt    120

aaagcattcg agcagatctc tgacaaagta tgggataacg aaaaaatcgt tatcatcttc    180

gaccacaaca tcccggctaa cacctctaaa gctgctaaca tgcaagttat cactcgtgaa    240

ttcatcaaga agcagggtat caaaaactac tacctggacg gtgaaggtat ctgccaccag    300

gttctgccgg aaaaaggtca cgttaagccg aacatgatca tcgctggtgc tgactctcac    360

acctgtactc acggtgcatt cggtgcattc gcaactggct tcggtgcaac tgacatgggt    420

tacgtttacg caactggtaa aacctggctg cgcgtaccag aaaccattca ggttaacgta    480

actggcgaaa acgaaaacat ctccggtaaa gacatcatcc tgaaaacctg taaagaagtt    540

ggtcgtcgcg gtgcaactta cctctctctg gaatacggtg gtaacgcggt acagaacctg    600

gatatggacg aacgtatggt tctgtctaac atggctatcg aaatgggtgg taaagcgggt    660

atcatcgaag ctgacgacac cacttacaaa tacctggaaa acgctggcgt ttcccgtgaa    720

gaaatcctga acctgaagaa aaacaagatc aaagttaacg aatctgaaga aaactactac    780

aaaactttcg agttcgacat cactgacatg gaagagcaga tcgcttgccc gcaccacccg    840

gacaacgtta aaggcgtttc tgaagtttct ggtatcgaac tggatcaggt attcatcggt    900

tcctgcacca acggtcgtct gaacgatctg cgtatcgctg cgaagcacct gaaaggtaag    960

aaagttaacg aatccactcg tctgatcgtt atcccggctt ccaagtctat cttcaaagaa   1020

gcgctgaaag aaggtctgat cgacaccttc gttgactccg gtgcgctgat ctgtactccg   1080

ggttgcggtc cgtgcctggg tgcacaccag ggcgtactgg gtgacggtga agtttgcctg   1140

gcaactacca accgtaactt caaaggtcgt atgggtaaca ccaagtctga agtttacctc   1200

tcttctccgg caatcgctgc gaagtctgct gttaaaggtt acatcactaa cgagtaa      1257


<210>  180
<211>  486
<212>  DNA
<213>  Artificial

<220>
<223>  AksE E. coli codon optimised

<400>  180
atgaagatca ccggtaaagt tcacgtattc ggtgacgaca tcgacactga cgctatcatt     60

ccgggtgctt acctgaaaac cactgacgaa tacgaactgg cttctcactg catggcgggt    120

atcgacgaag atttcccgga aatggttaaa gaaggtgact tcctggttgc tggcgaaaac    180

ttcggttgcg gttcttcccg tgagcaggca ccgatcgcta tcaaatactg cggtatcaaa    240

gcaatcatcg ttgaatcctt cgcacgtatc ttctaccgta actgcatcaa cctgggcgta    300

ttcccgatcg aatgtaaagg tatctccaag cacgttaaag acggtgacct gatcgaactg    360

gatctggaaa acaagaaagt tatcctgaaa gacaaagttc tggactgcca catcccgact    420

ggtactgcga aagacatcat ggacgaaggt ggtctgatca actacgctaa gaagcagaaa    480

aactaa                                                               486


<210>  181
<211>  1161
<212>  DNA
<213>  Methanococcus maripaludis

<400>  181
atggattgga aagctgtatc tccgtacaac cctaaattaa atttgaaaga ctgttatttg     60

tatgatacga cattgagaga tggtgaacag actcccggag tttgttttac acatgatcaa    120

aaacttgaga tcgccaaaaa actggatgaa cttaaaatta aacagatcga agcgggtttt    180

ccaattgttt ctgaaaacga gagaaaagcc atcaaatcaa ttactggcga aggattaaat    240

gcacaaattt tggcgttatc aagagtttta aaagaggata ttgataaagc cattgaatgt    300

gatgttgatg gaataattac attcattgca gcttcaccaa tgcatttgaa atacaaattg    360

cacaaaagcc tcgatgaagt cgaagaaatg ggtatgaaag ccgttgaata cgcaaaagat    420

cacggacttt tcgtagcatt ctctgcagaa gatgcgacaa gaactcctgt tgaagacctc    480

atcagaatcc acaaaaatgc agaagaacac ggtgccaata gggtgcatat tgcagatacc    540

ctcgggtgtg caacaccaca ggcaatgtat catatctgct ctgaattaag cagtaacttg    600

aaaaaagcac atatcggggt acactgtcac aacgactttg ggttcgcagt tataaactcg    660

atatacggat taattggtgg agcaaaagcg gtatctacaa cagttaacgg aataggcgaa    720

agagcaggaa atgctgcaat tgaagaaatt gtaatggcat tgaaagtact ttacgaccac    780

gatatgggat taaatactga aatactaact gaaatatcga aactcgttga aaactattca    840

aaaattagga ttcccgaaaa taaacctctt gttggggaaa tggcatttta ccatgaaagc    900

ggaatacatg ttgatgcggt tttagagaat cctttaacgt atgaaccgtt tttacctgaa    960

aaaataggtc aaaaaagaaa aattatactt ggaaaacatt ccggatgcag agcagttgca   1020

cacagactgc aagaacttgg gcttgaagct tcaagagaag aactttggga aattgtgaaa   1080

aaaactaaag aaaccagaga agaaggtact gaaataagcg acgaagtgtt taaaaacatt   1140

gtcgataaga ttataaaata a                                             1161


<210>  182
<211>  1020
<212>  DNA
<213>  Methanococcus maripaludis

<400>  182
atgagaaaca ctcccaaaat ttgtgttatt aatggagatg gcattggaaa cgaagtgatt     60

cctgaaacag tgcgcgtctt gaatgaaatt ggggattttg aatttataga aacacatgcg    120

ggctacgaat gttttaaaag atgtggcgat gcgatacctg aaaagaccat agaaattgca    180

aaagaatctg attctattct ttttggatct gttactaccc caaaaccaac tgaattaaaa    240

aataaaccct atagaagtcc aatattaact ttaagaaaag aactcgacct ttatgcaaat    300

ataagaccga ctttcaactt caaaaacctt gattttgtga taattcgcga aaataccgaa    360

ggtctttatg tgaaaaaaga atattacgac gaaaaaaatg aagttgcgac tgctgaacga    420

attatttcta aatttggaag ctcgagaatt gtaaaatttg cttttgatta tgcacttcaa    480

aacaatagaa aaaaagtatc ctgtattcac aaagcaaatg ttttgaggat cacagatggg    540

ttattcctag gggtatttga agaaatatcg aaaaaatatg aaaaattggg aatagtgtct    600

gatgactatt tgattgatgc aacagcgatg tatttaatta gaaatccgca aatgtttgat    660

gtcatggtta caacaaattt atttggagat attttatcgg atgaagctgc tggacttatc    720

ggaggacttg gaatgtctcc ttcagcaaat attggtgaca aaaacggatt attcgaacca    780

gtgcatggat ccgcaccaga tattgctgga aaaggaattt caaacccgat tgcaacaatt    840

ttaagtgctg caatgatgct tgatcattta aaaataaata aagaagcgga atacataaga    900

aatgcagtta aaaaaactgt tgaatgtaaa tacctaactc cggatcttgg gggacactta    960

aaaacttctg aagttacaga aaaaatcatt gaatcaataa aatctcaaat gattcaatga   1020


<210>  183
<211>  1257
<212>  DNA
<213>  Methanococcus maripaludis

<400>  183
atgacacttg ctgaaaaaat catttctaaa aatgttggaa aaaatgttta cgcgggcgat     60

agcgttgaaa tagacgtgga tgtcgcaatg acgcatgacg ggactacccc tcttacagta    120

aaagcttttg agcagatttc agacaaagtt tgggataatg aaaagatagt tattattttt    180

gaccacaaca tccctgcaaa cacgtcaaaa gctgcgaata tgcaggttat aacgagagaa    240

tttatcaaaa aacagggaat taaaaattat taccttgatg gcgaaggaat atgtcatcag    300

gtacttcctg aaaaaggcca cgtgaagcca aacatgataa ttgcaggagc tgacagtcac    360

acctgtactc atggggcatt cggtgctttt gcgacaggtt ttggtgcaac tgacatgggt    420

tacgtctatg caaccggaaa aacatggctt agagttcctg aaaccattca agtaaatgta    480

accggagaaa atgaaaatat ttctggaaag gacattatct taaaaacttg taaggaagtt    540

ggaagacgtg gagcgacata cctgtcttta gaatacggcg gaaatgcagt ccaaaatctt    600

gacatggacg aaagaatggt tttatcgaac atggccattg aaatgggcgg aaaagctgga    660

attatcgaag ctgacgatac tacttacaaa taccttgaaa atgcaggagt ttcaagagaa    720

gaaattctta acttgaaaaa aaataaaata aaagttaatg aatccgaaga aaattactac    780

aaaacatttg aatttgatat aaccgatatg gaagaacaga ttgcttgccc gcaccaccct    840

gacaatgtaa aaggagtttc tgaagtatca ggaattgaat tagatcaggt attcatcgga    900

tcttgtacaa acggaagatt aaacgattta agaattgctg caaaacattt gaaaggaaaa    960

aaagttaatg aaagcacccg actaattgta attcctgcat caaaatcaat ctttaaagaa   1020

gcgttaaaag aaggattaat cgatactttt gtagattctg gagcattaat ctgcactcct   1080

ggatgcggac catgccttgg agcccatcag ggtgttttag gtgatgggga agtatgtctt   1140

gctacaacca ataggaactt taaaggaaga atgggaaaca caaaatcgga agtttacctc   1200

tcatctcctg caatagctgc aaaatccgca gttaaaggat acattaccaa tgaataa      1257


<210>  184
<211>  486
<212>  DNA
<213>  Methanococcus maripaludis

<400>  184
atgaaaataa caggcaaggt gcacgtattt ggggatgaca tcgacacaga tgcgataatt     60

cctggcgctt atttaaaaac aactgatgaa tatgagcttg catcacactg tatggctgga    120

atcgatgaag attttccaga aatggtcaaa gaaggcgact ttttggtagc aggtgagaat    180

ttcggatgcg gaagttcgag agagcaagct ccaattgcaa taaaatactg cggaatcaag    240

gcaataattg ttgaaagttt tgcaaggata ttttatagaa attgtattaa tcttggagtt    300

tttccaattg aatgcaaagg aatatcaaaa cacgtgaaag atggagattt aatagaattg    360

gatctcgaaa ataaaaaagt aattttaaag gacaaggttc tagactgcca cattccaacc    420

ggaactgcaa aagacataat ggatgaaggc gggcttataa attacgcaaa gaaacagaaa    480

aactaa                                                               486


<210>  185
<211>  1113
<212>  DNA
<213>  Homo sapiens

<400>  185
atgctccccc ggctaatttg tatcaatgat tatgaacaac atgctaaatc agtacttcca     60

aagtctatat atgactatta caggtctggg gcaaatgatg aagaaacttt ggctgataat    120

attgcagcat tttccagatg gaagctgtat ccaaggatgc tccggaatgt tgctgaaaca    180

gatctgtcga cttctgtttt aggacagagg gtcagcatgc caatatgtgt gggggctacg    240

gccatgcagc gcatggctca tgtggacggc gagcttgcca ctgtgagagc ctgtcagtcc    300

ctgggaacgg gcatgatgtt gagttcctgg gccacctcct caattgaaga agtggcggaa    360

gctggtcctg aggcacttcg ttggctgcaa ctgtatatct acaaggaccg agaagtcacc    420

aagaagctag tgcggcaggc agagaagatg ggctacaagg ccatatttgt gacagtggac    480

acaccttacc tgggcaaccg tctggatgat gtgcgtaaca gattcaaact gccgccacaa    540

ctcaggatga aaaattttga aaccagtact ttatcatttt ctcctgagga aaattttgga    600

gacgacagtg gacttgctgc atatgtggct aaagcaatag acccatctat cagctgggaa    660

gatatcaaat ggctgagaag actgacatca ttgccaattg ttgcaaaggg cattttgaga    720

ggtgatgatg ccagggaggc tgttaaacat ggcttgaatg ggatcttggt gtcgaatcat    780

ggggctcgac aactcgatgg ggtgccagcc actattgatg ttctgccaga aattgtggag    840

gctgtggaag ggaaggtgga agtcttcctg gacgggggtg tgcggaaagg cactgatgtt    900

ctgaaagctc tggctcttgg cgccaaggct gtgtttgtgg ggagaccaat cgtttggggc    960

ttagctttcc agggggagaa aggtgttcaa gatgtcctcg agatactaaa ggaagaattc   1020

cggttggcca tggctctgag tgggtgccag aatgtgaaag tcatcgacaa gacattggtg   1080

aggaaaaatc ctttggccgt ttccaagatc tga                                1113


<210>  186
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  186

Met Leu Pro Arg Leu Ile Cys Ile Asn Asp Tyr Glu Gln His Ala Lys 
1               5                   10                  15      


Ser Val Leu Pro Lys Ser Ile Tyr Asp Tyr Tyr Arg Ser Gly Ala Asn 
            20                  25                  30          


Asp Glu Glu Thr Leu Ala Asp Asn Ile Ala Ala Phe Ser Arg Trp Lys 
        35                  40                  45              


Leu Tyr Pro Arg Met Leu Arg Asn Val Ala Glu Thr Asp Leu Ser Thr 
    50                  55                  60                  


Ser Val Leu Gly Gln Arg Val Ser Met Pro Ile Cys Val Gly Ala Thr 
65                  70                  75                  80  


Ala Met Gln Arg Met Ala His Val Asp Gly Glu Leu Ala Thr Val Arg 
                85                  90                  95      


Ala Cys Gln Ser Leu Gly Thr Gly Met Met Leu Ser Ser Trp Ala Thr 
            100                 105                 110         


Ser Ser Ile Glu Glu Val Ala Glu Ala Gly Pro Glu Ala Leu Arg Trp 
        115                 120                 125             


Leu Gln Leu Tyr Ile Tyr Lys Asp Arg Glu Val Thr Lys Lys Leu Val 
    130                 135                 140                 


Arg Gln Ala Glu Lys Met Gly Tyr Lys Ala Ile Phe Val Thr Val Asp 
145                 150                 155                 160 


Thr Pro Tyr Leu Gly Asn Arg Leu Asp Asp Val Arg Asn Arg Phe Lys 
                165                 170                 175     


Leu Pro Pro Gln Leu Arg Met Lys Asn Phe Glu Thr Ser Thr Leu Ser 
            180                 185                 190         


Phe Ser Pro Glu Glu Asn Phe Gly Asp Asp Ser Gly Leu Ala Ala Tyr 
        195                 200                 205             


Val Ala Lys Ala Ile Asp Pro Ser Ile Ser Trp Glu Asp Ile Lys Trp 
    210                 215                 220                 


Leu Arg Arg Leu Thr Ser Leu Pro Ile Val Ala Lys Gly Ile Leu Arg 
225                 230                 235                 240 


Gly Asp Asp Ala Arg Glu Ala Val Lys His Gly Leu Asn Gly Ile Leu 
                245                 250                 255     


Val Ser Asn His Gly Ala Arg Gln Leu Asp Gly Val Pro Ala Thr Ile 
            260                 265                 270         


Asp Val Leu Pro Glu Ile Val Glu Ala Val Glu Gly Lys Val Glu Val 
        275                 280                 285             


Phe Leu Asp Gly Gly Val Arg Lys Gly Thr Asp Val Leu Lys Ala Leu 
    290                 295                 300                 


Ala Leu Gly Ala Lys Ala Val Phe Val Gly Arg Pro Ile Val Trp Gly 
305                 310                 315                 320 


Leu Ala Phe Gln Gly Glu Lys Gly Val Gln Asp Val Leu Glu Ile Leu 
                325                 330                 335     


Lys Glu Glu Phe Arg Leu Ala Met Ala Leu Ser Gly Cys Gln Asn Val 
            340                 345                 350         


Lys Val Ile Asp Lys Thr Leu Val Arg Lys Asn Pro Leu Ala Val Ser 
        355                 360                 365             


Lys Ile 
    370 


<210>  187
<211>  1113
<212>  DNA
<213>  Artificial

<220>
<223>  human sequence codon optimised

<400>  187
atgctgccac gtctgatttg tattaacgat tacgaacaac acgcgaagag cgtactgccg     60

aaatccattt acgattatta ccgttctggt gcaaacgatg aagaaacgct ggctgataac    120

atcgccgctt tttcccgttg gaaactgtac ccacgtatgc tgcgtaacgt tgccgaaacc    180

gacctgtcca ccagcgtcct gggtcagcgt gtgtccatgc caatctgcgt gggtgcaacc    240

gcaatgcagc gtatggcaca cgttgacggc gaactggcaa ccgtccgtgc gtgccagagc    300

ctgggtaccg gtatgatgct gagcagctgg gctacctcta gcatcgagga agtggcagaa    360

gctggtccgg aagcactgcg ctggctgcag ctgtacatct acaaagatcg cgaagtcact    420

aagaaactgg tgcgccaggc ggaaaagatg ggttacaagg caatctttgt gactgttgac    480

accccgtacc tgggtaaccg cctggatgac gttcgtaacc gcttcaagct gccgccgcag    540

ctgcgtatga agaactttga aaccagcacc ctgtcctttt ccccagaaga aaatttcggt    600

gatgactctg gtctggccgc gtacgtcgcg aaagctatcg atccgtccat ctcctgggaa    660

gatatcaaat ggctgcgtcg tctgacttcc ctgccgatcg ttgctaaggg tattctgcgt    720

ggtgacgacg cgcgtgaagc tgttaaacat ggtctgaacg gcattctggt aagcaaccat    780

ggcgcacgcc agctggatgg tgtacctgct actattgatg tgctgccgga aatcgtggaa    840

gcggttgaag gtaaagttga agtgttcctg gacggtggtg tgcgcaaagg caccgatgta    900

ctgaaagcac tggcgctggg tgcgaaagcc gtctttgttg gccgtcctat tgtttggggt    960

ctggcattcc agggtgagaa aggtgtacag gacgttctgg agatcctgaa agaggagttc   1020

cgcctggcta tggcgctgtc tggttgtcaa aacgtgaaag taatcgataa aaccctggta   1080

cgtaaaaacc ctctggcagt aagcaagatc taa                                1113


<210>  188
<211>  1125
<212>  DNA
<213>  Aerococcus viridans

<400>  188
atgaataaca atgacattga atataatgca cctagtgaaa tcaagtacat tgatgttgtc     60

aatacttacg acttagaaga agaagcaagt aaagtggtac cacatggtgg ttttaactat    120

attgccggtg catctggtga tgagtggact aaacgcgcta atgaccgtgc ttggaaacat    180

aaattactat acccacgtct agcgcaagat gttgaagcgc ccgatacaag tactgaaatt    240

ttaggtcata aaattaaagc cccattcatc atggcaccaa ttgctgcaca tggtttagcc    300

cacactacta aagaagctgg tactgcacgt gcagtttcag aatttggtac aattatgtcc    360

atctcagctt attctggtgc aacatttgaa gaaatttctg aaggcttaaa tggcggaccc    420

cgttggttcc aaatctatat ggctaaagat gaccaacaaa accgtgatat cttagacgaa    480

gctaaatctg atggtgcaac tgctatcatc cttacagctg actcaactgt ttctggaaac    540

cgtgaccgtg atgtgaagaa taaattcgtt tacccatttg gtatgccaat tgttcaacgt    600

tacttacgtg gtacagcaga aggtatgtca ttaaacaata tctacggtgc ttcaaaacaa    660

aaaatctcac caagagatat tgaggaaatc gccggtcatt ctggattacc agtattcgtt    720

aaaggtattc aacacccaga agatgcagat atggcaatca aacgtggtgc atcaggtatc    780

tgggtatcta accacggtgc tcgtcaacta tatgaagctc caggttcatt tgacaccctt    840

ccagctattg ctgaacgtgt aaacaaacgt gtaccaatcg tctttgattc aggtgtacgt    900

cgtggtgaac acgttgccaa agcgctagct tcaggggcag acgttgttgc tttaggacgc    960

ccagtcttat ttggtttagc tttaggtggc tggcaaggtg cttactcagt acttgactac   1020

ttccaaaaag acttaacacg cgtaatgcaa ttaacaggtt cacaaaatgt ggaagacttg   1080

aagggtctag atttattcga taacccatac ggttatgaat actag                   1125


<210>  189
<211>  374
<212>  PRT
<213>  Aerococcus viridans

<400>  189

Met Asn Asn Asn Asp Ile Glu Tyr Asn Ala Pro Ser Glu Ile Lys Tyr 
1               5                   10                  15      


Ile Asp Val Val Asn Thr Tyr Asp Leu Glu Glu Glu Ala Ser Lys Val 
            20                  25                  30          


Val Pro His Gly Gly Phe Asn Tyr Ile Ala Gly Ala Ser Gly Asp Glu 
        35                  40                  45              


Trp Thr Lys Arg Ala Asn Asp Arg Ala Trp Lys His Lys Leu Leu Tyr 
    50                  55                  60                  


Pro Arg Leu Ala Gln Asp Val Glu Ala Pro Asp Thr Ser Thr Glu Ile 
65                  70                  75                  80  


Leu Gly His Lys Ile Lys Ala Pro Phe Ile Met Ala Pro Ile Ala Ala 
                85                  90                  95      


His Gly Leu Ala His Thr Thr Lys Glu Ala Gly Thr Ala Arg Ala Val 
            100                 105                 110         


Ser Glu Phe Gly Thr Ile Met Ser Ile Ser Ala Tyr Ser Gly Ala Thr 
        115                 120                 125             


Phe Glu Glu Ile Ser Glu Gly Leu Asn Gly Gly Pro Arg Trp Phe Gln 
    130                 135                 140                 


Ile Tyr Met Ala Lys Asp Asp Gln Gln Asn Arg Asp Ile Leu Asp Glu 
145                 150                 155                 160 


Ala Lys Ser Asp Gly Ala Thr Ala Ile Ile Leu Thr Ala Asp Ser Thr 
                165                 170                 175     


Val Ser Gly Asn Arg Asp Arg Asp Val Lys Asn Lys Phe Val Tyr Pro 
            180                 185                 190         


Phe Gly Met Pro Ile Val Gln Arg Tyr Leu Arg Gly Thr Ala Glu Gly 
        195                 200                 205             


Met Ser Leu Asn Asn Ile Tyr Gly Ala Ser Lys Gln Lys Ile Ser Pro 
    210                 215                 220                 


Arg Asp Ile Glu Glu Ile Ala Gly His Ser Gly Leu Pro Val Phe Val 
225                 230                 235                 240 


Lys Gly Ile Gln His Pro Glu Asp Ala Asp Met Ala Ile Lys Arg Gly 
                245                 250                 255     


Ala Ser Gly Ile Trp Val Ser Asn His Gly Ala Arg Gln Leu Tyr Glu 
            260                 265                 270         


Ala Pro Gly Ser Phe Asp Thr Leu Pro Ala Ile Ala Glu Arg Val Asn 
        275                 280                 285             


Lys Arg Val Pro Ile Val Phe Asp Ser Gly Val Arg Arg Gly Glu His 
    290                 295                 300                 


Val Ala Lys Ala Leu Ala Ser Gly Ala Asp Val Val Ala Leu Gly Arg 
305                 310                 315                 320 


Pro Val Leu Phe Gly Leu Ala Leu Gly Gly Trp Gln Gly Ala Tyr Ser 
                325                 330                 335     


Val Leu Asp Tyr Phe Gln Lys Asp Leu Thr Arg Val Met Gln Leu Thr 
            340                 345                 350         


Gly Ser Gln Asn Val Glu Asp Leu Lys Gly Leu Asp Leu Phe Asp Asn 
        355                 360                 365             


Pro Tyr Gly Tyr Glu Tyr 
    370                 


<210>  190
<211>  1125
<212>  DNA
<213>  Artificial

<220>
<223>  LAOX-8C A. viridans codon optimised

<400>  190
atgaacaaca acgacatcga atataacgct ccttctgaaa tcaaatatat cgacgtggtt     60

aacacctatg acctggagga agaagcgtct aaggtcgtac cgcacggtgg tttcaattac    120

attgcaggtg cctctggtga tgaatggacc aaacgcgcaa acgatcgtgc atggaaacac    180

aaactgctgt atccgcgcct ggcccaggat gtggaagcac cggatacttc cactgaaatc    240

ctgggtcaca aaatcaaggc accgtttatt atggctccga tcgcagcgca cggcctggca    300

cacaccacca aagaagctgg caccgctcgt gcggtttctg agttcggcac cattatgtct    360

atctctgcgt atagcggtgc cactttcgag gaaatttccg agggcctgaa cggtggcccg    420

cgttggtttc agatttacat ggcgaaagat gaccagcaga accgcgatat cctggatgaa    480

gccaaatctg acggcgcgac tgctatcatc ctgaccgcgg actctaccgt atccggtaac    540

cgtgaccgtg atgtgaagaa caagttcgtc tatcctttcg gtatgccgat tgttcagcgc    600

tatctgcgcg gtaccgctga gggtatgagc ctgaacaaca tctatggtgc gtccaaacag    660

aaaatcagcc cacgtgacat cgaagaaatt gctggtcata gcggtctgcc ggtgtttgtg    720

aaaggtatcc agcatccaga agatgcggac atggcaatca aacgtggtgc gtctggcatc    780

tgggttagca accacggtgc gcgtcagctg tacgaagctc cgggtagctt cgataccctg    840

ccggccatcg cggaacgtgt gaataaacgc gtgccgatcg ttttcgattc cggtgtgcgt    900

cgtggtgaac atgtggcaaa agcactggcg tctggcgctg atgtcgtagc actgggccgt    960

ccagtgctgt tcggtctggc tctgggtggc tggcagggcg cttactccgt cctggattac   1020

tttcagaaag acctgacccg tgttatgcag ctgaccggtt cccagaacgt agaggacctg   1080

aaaggcctgg acctgttcga caacccttac ggttacgaat actaa                   1125


<210>  191
<211>  314
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  191

Met Lys Glu Thr Val Gly Asn Lys Ile Val Leu Ile Gly Ala Gly Asp 
1               5                   10                  15      


Val Gly Val Ala Tyr Ala Tyr Ala Leu Ile Asn Gln Gly Met Ala Asp 
            20                  25                  30          


His Leu Ala Ile Ile Asp Ile Asp Glu Lys Lys Leu Glu Gly Asn Val 
        35                  40                  45              


Met Asp Leu Asn His Gly Val Val Trp Ala Asp Ser Arg Thr Arg Val 
    50                  55                  60                  


Thr Lys Gly Thr Tyr Ala Asp Cys Glu Asp Ala Ala Met Val Val Ile 
65                  70                  75                  80  


Cys Ala Gly Ala Ala Gln Lys Pro Gly Glu Thr Arg Leu Gln Leu Val 
                85                  90                  95      


Asp Lys Asn Val Lys Ile Met Lys Ser Ile Val Gly Asp Val Met Asp 
            100                 105                 110         


Ser Gly Phe Asp Gly Ile Phe Leu Val Ala Ser Asn Pro Val Asp Ile 
        115                 120                 125             


Leu Thr Tyr Ala Val Trp Lys Phe Ser Gly Leu Glu Trp Asn Arg Val 
    130                 135                 140                 


Ile Gly Ser Gly Thr Val Leu Asp Ser Ala Arg Phe Arg Tyr Met Leu 
145                 150                 155                 160 


Gly Glu Leu Tyr Glu Val Ala Pro Ser Ser Val His Ala Tyr Ile Ile 
                165                 170                 175     


Gly Glu His Gly Asp Thr Glu Leu Pro Val Leu Ser Ser Ala Thr Ile 
            180                 185                 190         


Ala Gly Val Ser Leu Ser Arg Met Leu Asp Lys Asp Pro Glu Leu Glu 
        195                 200                 205             


Gly Arg Leu Glu Lys Ile Phe Glu Asp Thr Arg Asp Ala Ala Tyr His 
    210                 215                 220                 


Ile Ile Asp Ala Lys Gly Ser Thr Ser Tyr Gly Ile Gly Met Gly Leu 
225                 230                 235                 240 


Ala Arg Ile Thr Arg Ala Ile Leu Gln Asn Gln Asp Val Ala Val Pro 
                245                 250                 255     


Val Ser Ala Leu Leu His Gly Glu Tyr Gly Glu Glu Asp Ile Tyr Ile 
            260                 265                 270         


Gly Thr Pro Ala Val Val Asn Arg Arg Gly Ile Arg Arg Val Val Glu 
        275                 280                 285             


Leu Glu Ile Thr Asp His Glu Met Glu Arg Phe Lys His Ser Ala Asn 
    290                 295                 300                 


Thr Leu Arg Glu Ile Gln Lys Gln Phe Phe 
305                 310                 


<210>  192
<211>  329
<212>  PRT
<213>  Escherichia coli

<400>  192

Met Lys Leu Ala Val Tyr Ser Thr Lys Gln Tyr Asp Lys Lys Tyr Leu 
1               5                   10                  15      


Gln Gln Val Asn Glu Ser Phe Gly Phe Glu Leu Glu Phe Phe Asp Phe 
            20                  25                  30          


Leu Leu Thr Glu Lys Thr Ala Lys Thr Ala Asn Gly Cys Glu Ala Val 
        35                  40                  45              


Cys Ile Phe Val Asn Asp Asp Gly Ser Arg Pro Val Leu Glu Glu Leu 
    50                  55                  60                  


Lys Lys His Gly Val Lys Tyr Ile Ala Leu Arg Cys Ala Gly Phe Asn 
65                  70                  75                  80  


Asn Val Asp Leu Asp Ala Ala Lys Glu Leu Gly Leu Lys Val Val Arg 
                85                  90                  95      


Val Pro Ala Tyr Asp Pro Glu Ala Val Ala Glu His Ala Ile Gly Met 
            100                 105                 110         


Met Met Thr Leu Asn Arg Arg Ile His Arg Ala Tyr Gln Arg Thr Arg 
        115                 120                 125             


Asp Ala Asn Phe Ser Leu Glu Gly Leu Thr Gly Phe Thr Met Tyr Gly 
    130                 135                 140                 


Lys Thr Ala Gly Val Ile Gly Thr Gly Lys Ile Gly Val Ala Met Leu 
145                 150                 155                 160 


Arg Ile Leu Lys Gly Phe Gly Met Arg Leu Leu Ala Phe Asp Pro Tyr 
                165                 170                 175     


Pro Ser Ala Ala Ala Leu Glu Leu Gly Val Glu Tyr Val Asp Leu Pro 
            180                 185                 190         


Thr Leu Phe Ser Glu Ser Asp Val Ile Ser Leu His Cys Pro Leu Thr 
        195                 200                 205             


Pro Glu Asn Tyr His Leu Leu Asn Glu Ala Ala Phe Glu Gln Met Lys 
    210                 215                 220                 


Asn Gly Val Met Ile Val Asn Thr Ser Arg Gly Ala Leu Ile Asp Ser 
225                 230                 235                 240 


Gln Ala Ala Ile Glu Ala Leu Lys Asn Gln Lys Ile Gly Ser Leu Gly 
                245                 250                 255     


Met Asp Val Tyr Glu Asn Glu Arg Asp Leu Phe Phe Glu Asp Lys Ser 
            260                 265                 270         


Asn Asp Val Ile Gln Asp Asp Val Phe Arg Arg Leu Ser Ala Cys His 
        275                 280                 285             


Asn Val Leu Phe Thr Gly His Gln Ala Phe Leu Thr Ala Glu Ala Leu 
    290                 295                 300                 


Thr Ser Ile Ser Gln Thr Thr Leu Gln Asn Leu Ser Asn Leu Glu Lys 
305                 310                 315                 320 


Gly Glu Thr Cys Pro Asn Glu Leu Val 
                325                 


<210>  193
<211>  312
<212>  PRT
<213>  Escherichia coli

<400>  193

Met Lys Val Ala Val Leu Gly Ala Ala Gly Gly Ile Gly Gln Ala Leu 
1               5                   10                  15      


Ala Leu Leu Leu Lys Thr Gln Leu Pro Ser Gly Ser Glu Leu Ser Leu 
            20                  25                  30          


Tyr Asp Ile Ala Pro Val Thr Pro Gly Val Ala Val Asp Leu Ser His 
        35                  40                  45              


Ile Pro Thr Ala Val Lys Ile Lys Gly Phe Ser Gly Glu Asp Ala Thr 
    50                  55                  60                  


Pro Ala Leu Glu Gly Ala Asp Val Val Leu Ile Ser Ala Gly Val Ala 
65                  70                  75                  80  


Arg Lys Pro Gly Met Asp Arg Ser Asp Leu Phe Asn Val Asn Ala Gly 
                85                  90                  95      


Ile Val Lys Asn Leu Val Gln Gln Val Ala Lys Thr Cys Pro Lys Ala 
            100                 105                 110         


Cys Ile Gly Ile Ile Thr Asn Pro Val Asn Thr Thr Val Ala Ile Ala 
        115                 120                 125             


Ala Glu Val Leu Lys Lys Ala Gly Val Tyr Asp Lys Asn Lys Leu Phe 
    130                 135                 140                 


Gly Val Thr Thr Leu Asp Ile Ile Arg Ser Asn Thr Phe Val Ala Glu 
145                 150                 155                 160 


Leu Lys Gly Lys Gln Pro Gly Glu Val Glu Val Pro Val Ile Gly Gly 
                165                 170                 175     


His Ser Gly Val Thr Ile Leu Pro Leu Leu Ser Gln Val Pro Gly Val 
            180                 185                 190         


Ser Phe Thr Glu Gln Glu Val Ala Asp Leu Thr Lys Arg Ile Gln Asn 
        195                 200                 205             


Ala Gly Thr Glu Val Val Glu Ala Lys Ala Gly Gly Gly Ser Ala Thr 
    210                 215                 220                 


Leu Ser Met Gly Gln Ala Ala Ala Arg Phe Gly Leu Ser Leu Val Arg 
225                 230                 235                 240 


Ala Leu Gln Gly Glu Gln Gly Val Val Glu Cys Ala Tyr Val Glu Gly 
                245                 250                 255     


Asp Gly Gln Tyr Ala Arg Phe Phe Ser Gln Pro Leu Leu Leu Gly Lys 
            260                 265                 270         


Asn Gly Val Glu Glu Arg Lys Ser Ile Gly Thr Leu Ser Ala Phe Glu 
        275                 280                 285             


Gln Asn Ala Leu Glu Gly Met Leu Asp Thr Leu Lys Lys Asp Ile Ala 
    290                 295                 300                 


Leu Gly Glu Glu Phe Val Asn Lys 
305                 310         


<210>  194
<211>  312
<212>  PRT
<213>  Bacillus subtilis

<400>  194

Met Gly Asn Thr Arg Lys Lys Val Ser Val Ile Gly Ala Gly Phe Thr 
1               5                   10                  15      


Gly Ala Thr Thr Ala Phe Leu Ile Ala Gln Lys Glu Leu Ala Asp Val 
            20                  25                  30          


Val Leu Val Asp Ile Pro Gln Leu Glu Asn Pro Thr Lys Gly Lys Ala 
        35                  40                  45              


Leu Asp Met Leu Glu Ala Ser Pro Val Gln Gly Phe Asp Ala Lys Ile 
    50                  55                  60                  


Thr Gly Thr Ser Asn Tyr Glu Asp Thr Ala Gly Ser Asp Ile Val Val 
65                  70                  75                  80  


Ile Thr Ala Gly Ile Ala Arg Lys Pro Gly Met Ser Arg Asp Asp Leu 
                85                  90                  95      


Val Ser Thr Asn Glu Lys Ile Met Arg Ser Val Thr Gln Glu Ile Val 
            100                 105                 110         


Lys Tyr Ser Pro Asp Ser Ile Ile Val Val Leu Thr Asn Pro Val Asp 
        115                 120                 125             


Ala Met Thr Tyr Ala Val Tyr Lys Glu Ser Gly Phe Pro Lys Glu Arg 
    130                 135                 140                 


Val Ile Gly Gln Ser Gly Val Leu Asp Thr Ala Arg Phe Arg Thr Phe 
145                 150                 155                 160 


Val Ala Glu Glu Leu Asn Leu Ser Val Lys Asp Val Thr Gly Phe Val 
                165                 170                 175     


Leu Gly Gly His Gly Asp Asp Met Val Pro Leu Val Arg Tyr Ser Tyr 
            180                 185                 190         


Ala Gly Gly Ile Pro Leu Glu Thr Leu Ile Pro Lys Glu Arg Ile Asp 
        195                 200                 205             


Ala Ile Val Glu Arg Thr Arg Lys Gly Gly Gly Glu Ile Val Asn Leu 
    210                 215                 220                 


Leu Gly Asn Gly Ser Ala Tyr Tyr Ala Pro Ala Ala Ser Leu Thr Glu 
225                 230                 235                 240 


Met Val Glu Ala Ile Leu Lys Asp Gln Arg Arg Val Leu Pro Thr Ile 
                245                 250                 255     


Ala Tyr Leu Glu Gly Glu Tyr Gly Tyr Glu Gly Ile Tyr Leu Gly Val 
            260                 265                 270         


Pro Thr Ile Val Gly Gly Asn Gly Leu Glu Gln Ile Ile Glu Leu Glu 
        275                 280                 285             


Leu Thr Asp Tyr Glu Arg Ala Gln Leu Asn Lys Ser Val Glu Ser Val 
    290                 295                 300                 


Lys Asn Val Met Lys Val Leu Ser 
305                 310         


<210>  195
<211>  365
<212>  PRT
<213>  Pichia stipitis

<400>  195

Met Thr Leu Lys Gln Gln Val Leu Phe Val Gly Lys Pro Asn Thr Asn 
1               5                   10                  15      


Thr Glu Ala Tyr Lys Lys Phe Ser Ala Asn Phe Glu Val Ile Asn Tyr 
            20                  25                  30          


Lys Ile Thr Ser Lys Ser Gln Leu Ile Glu Asp Phe Glu Gly Arg Leu 
        35                  40                  45              


Arg Tyr Ile Glu Ala Ile Tyr Ala Gly Trp Gly Gly Phe Asp Gly Val 
    50                  55                  60                  


Gly Gly Phe Gln Gly Glu Val Leu Arg His Cys Pro Pro Asn Val Lys 
65                  70                  75                  80  


Val Val Ala Ile Cys Ser Ile Gly His Asp Gly Tyr Asp Thr Glu Gly 
                85                  90                  95      


Met Ser Lys Arg Gly Ile Thr Leu Thr Asn Val Pro Ser Val Ile Ala 
            100                 105                 110         


Ser Glu Ala Val Ala Asp Leu Val Leu Tyr Asn Thr Leu Ser Ser Phe 
        115                 120                 125             


Arg Asn Phe Lys Met Phe Glu Lys Asn Leu Gly Gly Lys Leu Thr Asn 
    130                 135                 140                 


Thr Gly Ala Leu Arg Thr Ala Leu Val Arg Gly Glu Phe Asp Gln Phe 
145                 150                 155                 160 


Asn Gly Val Pro Val Ile Lys Pro Thr Val Gly Gly Ala Phe Ala Ser 
                165                 170                 175     


Ser Cys Cys Gly Arg Asp Ile Leu Ser Pro Arg Gly His Asn Val Val 
            180                 185                 190         


Ile Val Gly Phe Gly Ser Ile Gly Lys Leu Ile Gly Glu Arg Leu Ala 
        195                 200                 205             


Cys Ile Gly Met Asn Ile His Tyr Val Lys Arg Ser Lys Leu Ser Glu 
    210                 215                 220                 


Gln Glu Glu Ala Ser Leu Gly Tyr Lys Val Thr Tyr His Ala Thr Leu 
225                 230                 235                 240 


Lys Asp Thr Lys Asn Ile Ala Asp Leu Val Val Ile Ala Cys Pro Gly 
                245                 250                 255     


Thr Ala His Thr Arg His Met Val Asn Glu Glu Met Ile Asn Asp Phe 
            260                 265                 270         


Ala Lys Pro Phe Arg Leu Ile Asn Ile Gly Arg Gly Tyr Val Val Asp 
        275                 280                 285             


Glu Lys Ala Leu Val Asn Gly Leu Gln Ser Gly Lys Ile Leu Phe Ala 
    290                 295                 300                 


Gly Leu Asp Val Phe Glu Asn Glu Pro Ser Ile Asn Pro Asp Leu Leu 
305                 310                 315                 320 


Asn Arg Gln Asp Val Val Leu Thr Pro His Ile Gly Ser Ser Thr Thr 
                325                 330                 335     


Glu Asn Phe Asn Tyr Thr Ala Ala Ala Ala Met Phe Asn Ile Glu Thr 
            340                 345                 350         


Val Leu Tyr Asp Arg Glu Asp Thr Ile Thr Arg Val Asn 
        355                 360                 365 


<210>  196
<211>  424
<212>  PRT
<213>  Pseudomonas putida

<400>  196

Met Ser Val Asp Pro Gln Lys Leu Leu Arg Glu Leu Phe Asp Thr Ala 
1               5                   10                  15      


Ile Ala Ala Ala His Pro Arg Gln Val Leu Glu Pro Tyr Leu Pro Ala 
            20                  25                  30          


Asp Arg Ser Gly Arg Val Ile Val Ile Gly Ala Gly Lys Ala Ala Ala 
        35                  40                  45              


Ala Met Ala Glu Val Val Glu Lys Ser Trp Gln Gly Glu Val Ser Gly 
    50                  55                  60                  


Leu Val Val Thr Arg Tyr Gly His Gly Ala Asn Cys Gln Lys Ile Glu 
65                  70                  75                  80  


Val Val Glu Ala Ala His Pro Val Pro Asp Ala Ala Gly Leu Ala Val 
                85                  90                  95      


Ala Lys Arg Val Leu Glu Leu Val Ser Asn Leu Asn Glu Glu Asp Arg 
            100                 105                 110         


Val Ile Phe Leu Leu Ser Gly Gly Gly Ser Ala Leu Leu Ala Leu Pro 
        115                 120                 125             


Ala Glu Gly Leu Thr Leu Ala Asp Lys Gln Gln Ile Asn Lys Ala Leu 
    130                 135                 140                 


Leu Lys Ser Gly Ala Thr Ile Gly Glu Met Asn Cys Val Arg Lys His 
145                 150                 155                 160 


Leu Ser Ala Ile Lys Gly Gly Arg Leu Ala Lys Ala Cys Trp Pro Ala 
                165                 170                 175     


Thr Val Tyr Thr Tyr Ala Ile Ser Asp Val Pro Gly Asp Leu Ala Thr 
            180                 185                 190         


Val Ile Ala Ser Gly Pro Thr Val Ala Asp Pro Ser Thr Ser Ala Asp 
        195                 200                 205             


Ala Leu Ala Ile Leu Lys Arg Tyr Asn Ile Glu Ala Pro Lys Ala Val 
    210                 215                 220                 


Ile Asp Trp Leu Asn Asn Pro Ala Ser Glu Thr Val Lys Ala Asp Asp 
225                 230                 235                 240 


Pro Ala Leu Ala Arg Ser His Phe Gln Leu Ile Ala Lys Pro Gln Gln 
                245                 250                 255     


Ser Leu Glu Ala Ala Ala Val Lys Ala Arg Gln Ala Gly Phe Ser Pro 
            260                 265                 270         


Leu Ile Leu Gly Asp Leu Glu Gly Glu Ser Arg Glu Val Ala Lys Val 
        275                 280                 285             


His Ala Gly Ile Ala Arg Gln Ile Val Gln His Gly Gln Pro Leu Lys 
    290                 295                 300                 


Ala Pro Cys Val Ile Leu Ser Gly Gly Glu Thr Thr Val Thr Val Arg 
305                 310                 315                 320 


Gly Asn Gly Arg Gly Gly Arg Asn Ala Glu Phe Leu Leu Ser Leu Thr 
                325                 330                 335     


Glu Ser Leu Lys Gly Leu Pro Gly Val Tyr Ala Leu Ala Gly Asp Thr 
            340                 345                 350         


Asp Gly Ile Asp Gly Ser Glu Glu Asn Ala Gly Ala Phe Met Thr Pro 
        355                 360                 365             


Ala Ser Tyr Ala Ser Ala Glu Ala Leu Gly Leu Ser Ala Ser Asp Glu 
    370                 375                 380                 


Leu Asp Asn Asn Asn Gly Tyr Gly Tyr Phe Ala Ala Leu Asp Ala Leu 
385                 390                 395                 400 


Ile Val Thr Glu Pro Thr Arg Thr Asn Val Asn Asp Phe Arg Ala Ile 
                405                 410                 415     


Leu Ile Leu Glu Thr Ala Gln Ser 
            420                 


<210>  197
<211>  347
<212>  PRT
<213>  Corynebacterium glutamicum

<400>  197

Met Pro Glu Val Thr Val Asn Ala Gln Gln Leu Thr Val Leu Cys Thr 
1               5                   10                  15      


Asp Ile Leu Thr Lys Thr Gly Val Pro Ala Ala Asp Ala His Leu Val 
            20                  25                  30          


Gly Asp Ser Leu Val Gln Ala Asp Leu Trp Gly His Pro Ser His Gly 
        35                  40                  45              


Val Leu Arg Leu Pro Trp Tyr Val Arg Arg Leu His Ser Gly Ala Met 
    50                  55                  60                  


Thr Thr His Ala His Val Glu Val Leu Asn Asp Leu Gly Ala Val Leu 
65                  70                  75                  80  


Ala Leu Asp Gly His Asn Gly Ile Gly Gln Val Leu Ala Asp His Ala 
                85                  90                  95      


Arg Lys Glu Ala Val Thr Arg Ala Met Met Phe Gly Ile Gly Ala Val 
            100                 105                 110         


Ser Val Arg Asn Ser Asn His Phe Gly Thr Ala Met Tyr Tyr Thr Arg 
        115                 120                 125             


Lys Ala Ala Ala Gln Gly Cys Val Ser Ile Leu Thr Thr Asn Ala Ser 
    130                 135                 140                 


Pro Ala Met Ala Pro Trp Gly Gly Arg Glu Lys Arg Ile Gly Thr Asn 
145                 150                 155                 160 


Pro Trp Ser Ile Ala Ala Pro Phe Gly Glu Thr Ala Thr Val Val Asp 
                165                 170                 175     


Ile Ala Asn Thr Ala Val Ala Arg Gly Lys Ile Tyr His Ala Arg Gln 
            180                 185                 190         


Thr Asn Met Pro Ile Pro Glu Thr Trp Ala Ile Thr Ser Glu Gly Ala 
        195                 200                 205             


Pro Thr Thr Asp Pro Ala Glu Ala Ile Asn Gly Val Val Leu Pro Met 
    210                 215                 220                 


Ala Gly His Lys Gly Tyr Ala Ile Ser Phe Met Met Asp Val Leu Ser 
225                 230                 235                 240 


Gly Val Leu Thr Gly Ser Gln His Ser Thr Lys Val His Gly Pro Tyr 
                245                 250                 255     


Asp Pro Thr Pro Pro Gly Gly Ala Gly His Leu Phe Ile Ala Leu Asp 
            260                 265                 270         


Val Ala Ala Phe Arg Asp Pro Gln Asp Phe Asp Asp Ala Leu Ser Asp 
        275                 280                 285             


Leu Val Gly Glu Val Lys Ser Thr Pro Lys Ala Gln Asn Thr Glu Glu 
    290                 295                 300                 


Ile Phe Tyr Pro Gly Glu Ser Glu Asp Arg Ala His Arg Lys Asn Ser 
305                 310                 315                 320 


Ala His Gly Ile Ser Leu Pro Glu Lys Thr Trp Met Glu Leu Gln Glu 
                325                 330                 335     


Leu Ala Ile Glu Asn His Val Val Thr His Arg 
            340                 345         


<210>  198
<211>  315
<212>  PRT
<213>  Vibrio fischeri

<400>  198

Met Lys Val Ser Tyr Tyr Glu Val Lys Glu Arg Leu Ile Arg Lys Phe 
1               5                   10                  15      


Ile Ala Ser Gly Leu Ala Trp Asp Asp Ala Asn Trp Val Thr Asp Val 
            20                  25                  30          


Leu Ile Ser Ser Glu Gln Arg Gly Asp Lys Ser His Gly Ile Lys His 
        35                  40                  45              


Ala Lys Asn Ile Phe Asp Val Ile Asn Ser Glu Cys Tyr Ile Ala Gln 
    50                  55                  60                  


Ala Pro Ile Ile His Asp Glu Arg Ser Ile Thr Ile Leu Asp Gly Gln 
65                  70                  75                  80  


Asn Ser Ile Gly Pro Ile Val Ala Lys Gln Ala Ile Asp Ile Ala Ile 
                85                  90                  95      


Lys Lys Ala Lys Lys Tyr Gly Thr Ala Ala Ile Ser Leu Arg Ser Ser 
            100                 105                 110         


Asn His Leu Phe Ser Leu Ser His Tyr Val Arg Tyr Ile Ala Asn Asn 
        115                 120                 125             


Asn Met Ile Gly Phe Ile Cys Ser Ser Ser Ser Pro Ala Met Ala Ala 
    130                 135                 140                 


Pro Asn Ser Leu Asn Ala Thr Ile Gly Thr Asn Pro Phe Ala Phe Gly 
145                 150                 155                 160 


Ala Pro Ser Ser Lys Asp Pro Ile Val Ile Asp Met Ser Ser Thr Asn 
                165                 170                 175     


Val Ala Arg Gly Lys Ile Lys Glu Tyr Lys Asp Ala Glu Leu Asp Ile 
            180                 185                 190         


Pro Val Ser Trp Ala Leu Asp Glu Tyr Gly Asn Pro Thr Thr Cys Ala 
        195                 200                 205             


Ile Glu Ala Leu Lys Gly Thr Leu Ser Pro Leu Gly Gly Tyr Lys Gly 
    210                 215                 220                 


Phe Ala Leu Gly Cys Met Ile Asp Ile Phe Ser Ser Val Leu Ser Gly 
225                 230                 235                 240 


Ser Ala Phe Ser Thr Gln Ile Thr Gly Thr Ser Leu His Met Glu Glu 
                245                 250                 255     


Ala Asp Val Asn Lys Lys Gly Asp Phe Leu Phe Val Leu Asp Ile Ser 
            260                 265                 270         


Lys Phe Ile Gln Leu Ser Glu Phe Lys Ile Arg Met Asp Glu Phe Ile 
        275                 280                 285             


His Ile Ile Glu Ser Asn Gly Gly Tyr Ile Pro Gly Thr Asn Tyr Ile 
    290                 295                 300                 


Asn Asn Gln Phe Ala Asp Ile Glu Ile Leu Asn 
305                 310                 315 


<210>  199
<211>  354
<212>  PRT
<213>  Bacillus weihenstephanensis

<400>  199

Met Glu Lys Arg Ile Val Cys Leu Ala Gly Asp Gly Val Gly Pro Glu 
1               5                   10                  15      


Ile Met Glu Ser Ala Lys Glu Val Leu His Met Val Glu Arg Leu Tyr 
            20                  25                  30          


Gly His His Phe His Leu Gln Asp Glu Tyr Phe Gly Gly Ala Ala Ile 
        35                  40                  45              


Asp Leu Asn Gly Gln Pro Leu Pro Gln Arg Thr Leu Ala Ala Cys Leu 
    50                  55                  60                  


Ala Ser Asp Ala Val Leu Leu Gly Ala Val Gly Gly Pro Arg Trp Asp 
65                  70                  75                  80  


Asp Ala Lys Glu Arg Pro Glu Lys Gly Leu Leu Ala Leu Arg Lys Gly 
                85                  90                  95      


Leu Gly Val Phe Ala Asn Val Arg Pro Val Thr Val Glu Ser Ala Thr 
            100                 105                 110         


Ala His Leu Ser Pro Leu Lys Asn Ala Asp Glu Ile Asp Phe Val Val 
        115                 120                 125             


Val Arg Glu Leu Thr Gly Gly Ile Tyr Phe Ser Tyr Pro Lys Glu Arg 
    130                 135                 140                 


Thr Glu Glu Ser Ala Thr Asp Thr Leu Thr Tyr His Arg His Glu Ile 
145                 150                 155                 160 


Glu Arg Ile Val Ser Tyr Ala Phe Gln Leu Ala Ser Lys Arg Glu Lys 
                165                 170                 175     


Lys Val Thr Ser Ile Asp Lys Ala Asn Val Leu Glu Ser Ser Lys Leu 
            180                 185                 190         


Trp Arg Ala Val Thr Glu Glu Val Ala Leu Arg Tyr Pro Asn Val Glu 
        195                 200                 205             


Leu Glu His Ile Leu Val Asp Ala Ala Ala Met Glu Leu Ile Arg Asn 
    210                 215                 220                 


Pro Arg Arg Phe Asp Val Ile Val Thr Glu Asn Leu Phe Gly Asp Ile 
225                 230                 235                 240 


Leu Ser Asp Glu Ala Ser Val Leu Ala Gly Ser Leu Gly Met Leu Pro 
                245                 250                 255     


Ser Ala Ser His Ala Glu Asn Gly Pro Ser Leu Tyr Glu Pro Ile His 
            260                 265                 270         


Gly Ser Ala Pro Asp Ile Ala Gly Lys Asn Lys Ala Asn Pro Ile Ala 
        275                 280                 285             


Met Met Arg Ser Val Ala Met Met Leu Gly Gln Ser Phe Gly Leu Thr 
    290                 295                 300                 


Arg Glu Gly Tyr Ala Ile Glu Glu Ala Ile Ser Ala Val Leu Gln Ser 
305                 310                 315                 320 


Gly Lys Cys Thr Ala Asp Ile Gly Gly Asn Glu Thr Thr Thr Ser Phe 
                325                 330                 335     


Thr Arg Ala Val Ile Gln Glu Met Glu Glu Gln Ala Leu Val Gly Arg 
            340                 345                 350         


Gly Arg 
        


<210>  200
<211>  349
<212>  PRT
<213>  Zymomonas mobilis

<400>  200

Met Arg Ile Ala Leu Leu Ala Gly Asp Gly Ile Gly Pro Glu Ile Thr 
1               5                   10                  15      


Ala Glu Ala Val Lys Ile Leu Lys Ala Val Val Gly Gln Glu Ile Glu 
            20                  25                  30          


Phe Asp Glu Ala Leu Ile Gly Gly Ala Ala Trp Lys Val Thr Gly Ser 
        35                  40                  45              


Pro Leu Pro Glu Glu Thr Leu Lys Leu Cys Lys Asn Ser Asp Ala Ile 
    50                  55                  60                  


Leu Phe Gly Ser Val Gly Asp Pro Glu Cys Asp His Leu Glu Arg Ala 
65                  70                  75                  80  


Leu Arg Pro Glu Gln Ala Ile Leu Gly Leu Arg Lys Glu Leu Asp Leu 
                85                  90                  95      


Phe Ala Asn Leu Arg Pro Ala Arg Leu Phe Pro Glu Leu Gln Ala Glu 
            100                 105                 110         


Ser Pro Leu Lys Glu Asn Ile Val Thr Gly Thr Asp Leu Met Ile Val 
        115                 120                 125             


Arg Glu Leu Thr Gly Asp Val Tyr Phe Gly Thr Pro Arg Gly Gln Arg 
    130                 135                 140                 


Lys Asp Asp Gln Asn Arg Arg Glu Gly Phe Asp Thr Met Arg Tyr Asn 
145                 150                 155                 160 


Glu Asp Glu Val Lys Arg Ile Ala Arg Ile Gly Phe Glu Thr Ala Arg 
                165                 170                 175     


Ser Arg Ser Gly Asn Leu Cys Ser Ile Asp Lys Ser Asn Val Leu Glu 
            180                 185                 190         


Thr Ser Gln Leu Trp Arg Thr Val Val Leu Glu Ile Ala Gln Glu Tyr 
        195                 200                 205             


Pro Asp Val Glu Leu Ser His Met Tyr Val Asp Asn Ala Ala Met Gln 
    210                 215                 220                 


Leu Val Arg Ala Pro Asp Gln Phe Asp Val Ile Val Thr Gly Asn Leu 
225                 230                 235                 240 


Phe Gly Asp Ile Leu Ser Asp Leu Ala Ser Ala Cys Val Gly Ser Ile 
                245                 250                 255     


Gly Leu Leu Pro Ser Ala Ser Leu Asn Ser Glu Gly Lys Gly Leu Tyr 
            260                 265                 270         


Glu Pro Ile His Gly Ser Ala Pro Asp Ile Ala Gly Leu Gly Lys Ala 
        275                 280                 285             


Asn Pro Leu Ala Thr Ile Leu Ser Gly Ala Met Met Leu Arg Tyr Ser 
    290                 295                 300                 


Leu Lys Arg Glu Ala Asp Ala Asp Arg Ile Glu Lys Ala Val Ser Thr 
305                 310                 315                 320 


Ala Leu Glu Lys Gly Ala Arg Thr Ala Asp Leu Gly Gly Lys Met Thr 
                325                 330                 335     


Thr Ser Glu Met Gly Asn Ala Val Leu Ala Ala Leu Asn 
            340                 345                 


<210>  201
<211>  361
<212>  PRT
<213>  Escherichia coli

<400>  201

Met Met Lys Thr Met Arg Ile Ala Ala Ile Pro Gly Asp Gly Ile Gly 
1               5                   10                  15      


Lys Glu Val Leu Pro Glu Gly Ile Arg Val Leu Gln Ala Ala Ala Glu 
            20                  25                  30          


Arg Trp Gly Phe Ala Leu Ser Phe Glu Gln Met Glu Trp Ala Ser Cys 
        35                  40                  45              


Glu Tyr Tyr Ser His His Gly Lys Met Met Pro Asp Asp Trp His Glu 
    50                  55                  60                  


Gln Leu Ser Arg Phe Asp Ala Ile Tyr Phe Gly Ala Val Gly Trp Pro 
65                  70                  75                  80  


Asp Thr Val Pro Asp His Ile Ser Leu Trp Gly Ser Leu Leu Lys Phe 
                85                  90                  95      


Arg Arg Glu Phe Asp Gln Tyr Val Asn Leu Arg Pro Val Arg Leu Phe 
            100                 105                 110         


Pro Gly Val Pro Cys Pro Leu Ala Gly Lys Gln Pro Gly Asp Ile Asp 
        115                 120                 125             


Phe Tyr Val Val Arg Glu Asn Thr Glu Gly Glu Tyr Ser Ser Leu Gly 
    130                 135                 140                 


Gly Arg Val Asn Glu Gly Thr Glu His Glu Val Val Ile Gln Glu Ser 
145                 150                 155                 160 


Val Phe Thr Arg Arg Gly Val Asp Arg Ile Leu Arg Tyr Ala Phe Glu 
                165                 170                 175     


Leu Ala Gln Ser Arg Pro Arg Lys Thr Leu Thr Ser Ala Thr Lys Ser 
            180                 185                 190         


Asn Gly Leu Ala Ile Ser Met Pro Tyr Trp Asp Glu Arg Val Glu Ala 
        195                 200                 205             


Met Ala Glu Asn Tyr Pro Glu Ile Arg Trp Asp Lys Gln His Ile Asp 
    210                 215                 220                 


Ile Leu Cys Ala Arg Phe Val Met Gln Pro Glu Arg Phe Asp Val Val 
225                 230                 235                 240 


Val Ala Ser Asn Leu Phe Gly Asp Ile Leu Ser Asp Leu Gly Pro Ala 
                245                 250                 255     


Cys Thr Gly Thr Ile Gly Ile Ala Pro Ser Ala Asn Leu Asn Pro Glu 
            260                 265                 270         


Arg Thr Phe Pro Ser Leu Phe Glu Pro Val His Gly Ser Ala Pro Asp 
        275                 280                 285             


Ile Tyr Gly Lys Asn Ile Ala Asn Pro Ile Ala Thr Ile Trp Ala Gly 
    290                 295                 300                 


Ala Met Met Leu Asp Phe Leu Gly Asn Gly Asp Glu Arg Phe Gln Gln 
305                 310                 315                 320 


Ala His Asn Gly Ile Leu Ala Ala Ile Glu Glu Val Ile Ala His Gly 
                325                 330                 335     


Pro Lys Thr Pro Asp Met Lys Gly Asn Ala Thr Thr Pro Gln Val Ala 
            340                 345                 350         


Asp Ala Ile Cys Lys Ile Ile Leu Arg 
        355                 360     


<210>  202
<211>  362
<212>  PRT
<213>  Aspergillus niger

<400>  202

Met Thr Thr Glu Thr Thr Thr Tyr Arg Ile Ala Ser Ile Pro Gly Asp 
1               5                   10                  15      


Gly Ile Gly Glu Glu Val Val Arg Ala Thr Ile Glu Val Ile Asn Lys 
            20                  25                  30          


Leu Ala Gln Thr Leu Asn Thr Phe Asn Ile Glu Phe Thr His Leu Pro 
        35                  40                  45              


Trp Gly Thr Glu Tyr Tyr Lys Gln His Gly Arg Tyr Val Ser Glu Gly 
    50                  55                  60                  


Tyr Leu Asp Thr Leu Arg Gln Phe Asp Ala Gly Leu Phe Gly Ser Val 
65                  70                  75                  80  


Gly His Pro Asp Val Pro Asp His Val Ser Leu Trp Gly Leu Leu Leu 
                85                  90                  95      


Ala Leu Arg Ser Pro Leu Gln Leu Tyr Ala Asn Val Arg Pro Val Arg 
            100                 105                 110         


Thr Phe Pro Gly Thr Lys Ser Pro Leu Thr Thr Ala Val Asn Gly Ile 
        115                 120                 125             


Asp Trp Val Leu Val Arg Glu Asn Ser Glu Gly Glu Tyr Cys Gly Gln 
    130                 135                 140                 


Gly Gly Arg Ser His Thr Gly Gln Pro Trp Glu Ala Ala Thr Glu Val 
145                 150                 155                 160 


Ala Ile Phe Thr Arg Val Gly Val Glu Arg Ile Met Arg Phe Ala Phe 
                165                 170                 175     


Glu Thr Ala Arg Ser Arg Pro Arg Arg His Leu Thr Val Val Thr Lys 
            180                 185                 190         


Ser Asn Ala Met Arg His Gly Met Val Leu Trp Asp Glu Val Ala Glu 
        195                 200                 205             


Glu Val Ala Lys Asp Phe Pro Asp Val Thr Trp Asp Lys Met Leu Val 
    210                 215                 220                 


Asp Ala Met Thr Leu Arg Met Ile Ser Lys Pro Glu Ser Leu Asp Thr 
225                 230                 235                 240 


Ile Val Gly Thr Asn Leu His Met Asp Ile Leu Ser Asp Leu Ala Ala 
                245                 250                 255     


Gly Leu Ala Gly Ser Ile Gly Val Ala Pro Ser Ser Asn Leu Asp Pro 
            260                 265                 270         


Thr Arg Lys Asn Pro Ser Leu Phe Glu Pro Val His Gly Ser Ala Phe 
        275                 280                 285             


Asp Ile Met Gly Lys Gly Val Ala Asn Pro Val Ala Thr Phe Trp Ser 
    290                 295                 300                 


Ala Ala Glu Met Leu Ala Trp Leu Gly Glu Lys Asp Ala Ala Lys Lys 
305                 310                 315                 320 


Leu Met Asp Cys Val Glu Lys Val Cys Ala Ala Gly Ile Leu Thr Pro 
                325                 330                 335     


Asp Leu Gly Gly Ser Ala Asn Thr Gln Gly Val Val Asp Ala Val Cys 
            340                 345                 350         


Lys Glu Ile Glu Gln Gln Leu Ala Ser Ser 
        355                 360         


<210>  203
<211>  591
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  203

Met Leu Lys Tyr Lys Pro Leu Leu Lys Ile Ser Lys Asn Cys Glu Ala 
1               5                   10                  15      


Ala Ile Leu Arg Ala Ser Lys Thr Arg Leu Asn Thr Ile Arg Ala Tyr 
            20                  25                  30          


Gly Ser Thr Val Pro Lys Ser Lys Ser Phe Glu Gln Asp Ser Arg Lys 
        35                  40                  45              


Arg Thr Gln Ser Trp Thr Ala Leu Arg Val Gly Ala Ile Leu Ala Ala 
    50                  55                  60                  


Thr Ser Ser Val Ala Tyr Leu Asn Trp His Asn Gly Gln Ile Asp Asn 
65                  70                  75                  80  


Glu Pro Lys Leu Asp Met Asn Lys Gln Lys Ile Ser Pro Ala Glu Val 
                85                  90                  95      


Ala Lys His Asn Lys Pro Asp Asp Cys Trp Val Val Ile Asn Gly Tyr 
            100                 105                 110         


Val Tyr Asp Leu Thr Arg Phe Leu Pro Asn His Pro Gly Gly Gln Asp 
        115                 120                 125             


Val Ile Lys Phe Asn Ala Gly Lys Asp Val Thr Ala Ile Phe Glu Pro 
    130                 135                 140                 


Leu His Ala Pro Asn Val Ile Asp Lys Tyr Ile Ala Pro Glu Lys Lys 
145                 150                 155                 160 


Leu Gly Pro Leu Gln Gly Ser Met Pro Pro Glu Leu Val Cys Pro Pro 
                165                 170                 175     


Tyr Ala Pro Gly Glu Thr Lys Glu Asp Ile Ala Arg Lys Glu Gln Leu 
            180                 185                 190         


Lys Ser Leu Leu Pro Pro Leu Asp Asn Ile Ile Asn Leu Tyr Asp Phe 
        195                 200                 205             


Glu Tyr Leu Ala Ser Gln Thr Leu Thr Lys Gln Ala Trp Ala Tyr Tyr 
    210                 215                 220                 


Ser Ser Gly Ala Asn Asp Glu Val Thr His Arg Glu Asn His Asn Ala 
225                 230                 235                 240 


Tyr His Arg Ile Phe Phe Lys Pro Lys Ile Leu Val Asp Val Arg Lys 
                245                 250                 255     


Val Asp Ile Ser Thr Asp Met Leu Gly Ser His Val Asp Val Pro Phe 
            260                 265                 270         


Tyr Val Ser Ala Thr Ala Leu Cys Lys Leu Gly Asn Pro Leu Glu Gly 
        275                 280                 285             


Glu Lys Asp Val Ala Arg Gly Cys Gly Gln Gly Val Thr Lys Val Pro 
    290                 295                 300                 


Gln Met Ile Ser Thr Leu Ala Ser Cys Ser Pro Glu Glu Ile Ile Glu 
305                 310                 315                 320 


Ala Ala Pro Ser Asp Lys Gln Ile Gln Trp Tyr Gln Leu Tyr Val Asn 
                325                 330                 335     


Ser Asp Arg Lys Ile Thr Asp Asp Leu Val Lys Asn Val Glu Lys Leu 
            340                 345                 350         


Gly Val Lys Ala Leu Phe Val Thr Val Asp Ala Pro Ser Leu Gly Gln 
        355                 360                 365             


Arg Glu Lys Asp Met Lys Leu Lys Phe Ser Asn Thr Lys Ala Gly Pro 
    370                 375                 380                 


Lys Ala Met Lys Lys Thr Asn Val Glu Glu Ser Gln Gly Ala Ser Arg 
385                 390                 395                 400 


Ala Leu Ser Lys Phe Ile Asp Pro Ser Leu Thr Trp Lys Asp Ile Glu 
                405                 410                 415     


Glu Leu Lys Lys Lys Thr Lys Leu Pro Ile Val Ile Lys Gly Val Gln 
            420                 425                 430         


Arg Thr Glu Asp Val Ile Lys Ala Ala Glu Ile Gly Val Ser Gly Val 
        435                 440                 445             


Val Leu Ser Asn His Gly Gly Arg Gln Leu Asp Phe Ser Arg Ala Pro 
    450                 455                 460                 


Ile Glu Val Leu Ala Glu Thr Met Pro Ile Leu Glu Gln Arg Asn Leu 
465                 470                 475                 480 


Lys Asp Lys Leu Glu Val Phe Val Asp Gly Gly Val Arg Arg Gly Thr 
                485                 490                 495     


Asp Val Leu Lys Ala Leu Cys Leu Gly Ala Lys Gly Val Gly Leu Gly 
            500                 505                 510         


Arg Pro Phe Leu Tyr Ala Asn Ser Cys Tyr Gly Arg Asn Gly Val Glu 
        515                 520                 525             


Lys Ala Ile Glu Ile Leu Arg Asp Glu Ile Glu Met Ser Met Arg Leu 
    530                 535                 540                 


Leu Gly Val Thr Ser Ile Ala Glu Leu Lys Pro Asp Leu Leu Asp Leu 
545                 550                 555                 560 


Ser Thr Leu Lys Ala Arg Thr Val Gly Val Pro Asn Asp Val Leu Tyr 
                565                 570                 575     


Asn Glu Val Tyr Glu Gly Pro Thr Leu Thr Glu Phe Glu Asp Ala 
            580                 585                 590     


<210>  204
<211>  396
<212>  PRT
<213>  Escherichia coli

<400>  204

Met Ile Ile Ser Ala Ala Ser Asp Tyr Arg Ala Ala Ala Gln Arg Ile 
1               5                   10                  15      


Leu Pro Pro Phe Leu Phe His Tyr Met Asp Gly Gly Ala Tyr Ser Glu 
            20                  25                  30          


Tyr Thr Leu Arg Arg Asn Val Glu Asp Leu Ser Glu Val Ala Leu Arg 
        35                  40                  45              


Gln Arg Ile Leu Lys Asn Met Ser Asp Leu Ser Leu Glu Thr Thr Leu 
    50                  55                  60                  


Phe Asn Glu Lys Leu Ser Met Pro Val Ala Leu Ala Pro Val Gly Leu 
65                  70                  75                  80  


Cys Gly Met Tyr Ala Arg Arg Gly Glu Val Gln Ala Ala Lys Ala Ala 
                85                  90                  95      


Asp Ala His Gly Ile Pro Phe Thr Leu Ser Thr Val Ser Val Cys Pro 
            100                 105                 110         


Ile Glu Glu Val Ala Pro Ala Ile Lys Arg Pro Met Trp Phe Gln Leu 
        115                 120                 125             


Tyr Val Leu Arg Asp Arg Gly Phe Met Arg Asn Ala Leu Glu Arg Ala 
    130                 135                 140                 


Lys Ala Ala Gly Cys Ser Thr Leu Val Phe Thr Val Asp Met Pro Thr 
145                 150                 155                 160 


Pro Gly Ala Arg Tyr Arg Asp Ala His Ser Gly Met Ser Gly Pro Asn 
                165                 170                 175     


Ala Ala Met Arg Arg Tyr Leu Gln Ala Val Thr His Pro Gln Trp Ala 
            180                 185                 190         


Trp Asp Val Gly Leu Asn Gly Arg Pro His Asp Leu Gly Asn Ile Ser 
        195                 200                 205             


Ala Tyr Leu Gly Lys Pro Thr Gly Leu Glu Asp Tyr Ile Gly Trp Leu 
    210                 215                 220                 


Gly Asn Asn Phe Asp Pro Ser Ile Ser Trp Lys Asp Leu Glu Trp Ile 
225                 230                 235                 240 


Arg Asp Phe Trp Asp Gly Pro Met Val Ile Lys Gly Ile Leu Asp Pro 
                245                 250                 255     


Glu Asp Ala Arg Asp Ala Val Arg Phe Gly Ala Asp Gly Ile Val Val 
            260                 265                 270         


Ser Asn His Gly Gly Arg Gln Leu Asp Gly Val Leu Ser Ser Ala Arg 
        275                 280                 285             


Ala Leu Pro Ala Ile Ala Asp Ala Val Lys Gly Asp Ile Ala Ile Leu 
    290                 295                 300                 


Ala Asp Ser Gly Ile Arg Asn Gly Leu Asp Val Val Arg Met Ile Ala 
305                 310                 315                 320 


Leu Gly Ala Asp Thr Val Leu Leu Gly Arg Ala Phe Leu Tyr Ala Leu 
                325                 330                 335     


Ala Thr Ala Gly Gln Ala Gly Val Ala Asn Leu Leu Asn Leu Ile Glu 
            340                 345                 350         


Lys Glu Met Lys Val Ala Met Thr Leu Thr Gly Ala Lys Ser Ile Ser 
        355                 360                 365             


Glu Ile Thr Gln Asp Ser Leu Val Gln Gly Leu Gly Lys Glu Leu Pro 
    370                 375                 380                 


Ala Ala Leu Ala Pro Met Ala Lys Gly Asn Ala Ala 
385                 390                 395     


<210>  205
<211>  587
<212>  PRT
<213>  Saccharomyces cerevisiae

<400>  205

Met Leu Trp Lys Arg Thr Cys Thr Arg Leu Ile Lys Pro Ile Ala Gln 
1               5                   10                  15      


Pro Arg Gly Arg Leu Val Arg Arg Ser Cys Tyr Arg Tyr Ala Ser Thr 
            20                  25                  30          


Gly Thr Gly Ser Thr Asp Ser Ser Ser Gln Trp Leu Lys Tyr Ser Val 
        35                  40                  45              


Ile Ala Ser Ser Ala Thr Leu Phe Gly Tyr Leu Phe Ala Lys Asn Leu 
    50                  55                  60                  


Tyr Ser Arg Glu Thr Lys Glu Asp Leu Ile Glu Lys Leu Glu Met Val 
65                  70                  75                  80  


Lys Lys Ile Asp Pro Val Asn Ser Thr Leu Lys Leu Ser Ser Leu Asp 
                85                  90                  95      


Ser Pro Asp Tyr Leu His Asp Pro Val Lys Ile Asp Lys Val Val Glu 
            100                 105                 110         


Asp Leu Lys Gln Val Leu Gly Asn Lys Pro Glu Asn Tyr Ser Asp Ala 
        115                 120                 125             


Lys Ser Asp Leu Asp Ala His Ser Asp Thr Tyr Phe Asn Thr His His 
    130                 135                 140                 


Pro Ser Pro Glu Gln Arg Pro Arg Ile Ile Leu Phe Pro His Thr Thr 
145                 150                 155                 160 


Glu Glu Val Ser Lys Ile Leu Lys Ile Cys His Asp Asn Asn Met Pro 
                165                 170                 175     


Val Val Pro Phe Ser Gly Gly Thr Ser Leu Glu Gly His Phe Leu Pro 
            180                 185                 190         


Thr Arg Ile Gly Asp Thr Ile Thr Val Asp Leu Ser Lys Phe Met Asn 
        195                 200                 205             


Asn Val Val Lys Phe Asp Lys Leu Asp Leu Asp Ile Thr Val Gln Ala 
    210                 215                 220                 


Gly Leu Pro Trp Glu Asp Leu Asn Asp Tyr Leu Ser Asp His Gly Leu 
225                 230                 235                 240 


Met Phe Gly Cys Asp Pro Gly Pro Gly Ala Gln Ile Gly Gly Cys Ile 
                245                 250                 255     


Ala Asn Ser Cys Ser Gly Thr Asn Ala Tyr Arg Tyr Gly Thr Met Lys 
            260                 265                 270         


Glu Asn Ile Ile Asn Met Thr Ile Val Leu Pro Asp Gly Thr Ile Val 
        275                 280                 285             


Lys Thr Lys Lys Arg Pro Arg Lys Ser Ser Ala Gly Tyr Asn Leu Asn 
    290                 295                 300                 


Gly Leu Phe Val Gly Ser Glu Gly Thr Leu Gly Ile Val Thr Glu Ala 
305                 310                 315                 320 


Thr Val Lys Cys His Val Lys Pro Lys Ala Glu Thr Val Ala Val Val 
                325                 330                 335     


Ser Phe Asp Thr Ile Lys Asp Ala Ala Ala Cys Ala Ser Asn Leu Thr 
            340                 345                 350         


Gln Ser Gly Ile His Leu Asn Ala Met Glu Leu Leu Asp Glu Asn Met 
        355                 360                 365             


Met Lys Leu Ile Asn Ala Ser Glu Ser Thr Asp Arg Cys Asp Trp Val 
    370                 375                 380                 


Glu Lys Pro Thr Met Phe Phe Lys Ile Gly Gly Arg Ser Pro Asn Ile 
385                 390                 395                 400 


Val Asn Ala Leu Val Asp Glu Val Lys Ala Val Ala Gln Leu Asn His 
                405                 410                 415     


Cys Asn Ser Phe Gln Phe Ala Lys Asp Asp Asp Glu Lys Leu Glu Leu 
            420                 425                 430         


Trp Glu Ala Arg Lys Val Ala Leu Trp Ser Val Leu Asp Ala Asp Lys 
        435                 440                 445             


Ser Lys Asp Lys Ser Ala Lys Ile Trp Thr Thr Asp Val Ala Val Pro 
    450                 455                 460                 


Val Ser Gln Phe Asp Lys Val Ile His Glu Thr Lys Lys Asp Met Gln 
465                 470                 475                 480 


Ala Ser Lys Leu Ile Asn Ala Ile Val Gly His Ala Gly Asp Gly Asn 
                485                 490                 495     


Phe His Ala Phe Ile Val Tyr Arg Thr Pro Glu Glu His Glu Thr Cys 
            500                 505                 510         


Ser Gln Leu Val Asp Arg Met Val Lys Arg Ala Leu Asn Ala Glu Gly 
        515                 520                 525             


Thr Cys Thr Gly Glu His Gly Val Gly Ile Gly Lys Arg Glu Tyr Leu 
    530                 535                 540                 


Leu Glu Glu Leu Gly Glu Ala Pro Val Asp Leu Met Arg Lys Ile Lys 
545                 550                 555                 560 


Leu Ala Ile Asp Pro Lys Arg Ile Met Asn Pro Asp Lys Ile Phe Lys 
                565                 570                 575     


Thr Asp Pro Asn Glu Pro Ala Asn Asp Tyr Arg 
            580                 585         


<210>  206
<211>  477
<212>  PRT
<213>  Gluconobacter oxydans

<400>  206

Met Pro Glu Pro Val Met Thr Ala Ser Ser Ala Ser Ala Pro Asp Arg 
1               5                   10                  15      


Leu Gln Ala Val Leu Lys Ala Leu Gln Pro Val Met Gly Glu Arg Ile 
            20                  25                  30          


Ser Thr Ala Pro Ser Val Arg Glu Glu His Ser His Gly Glu Ala Met 
        35                  40                  45              


Asn Ala Ser Asn Leu Pro Glu Ala Val Val Phe Ala Glu Ser Thr Gln 
    50                  55                  60                  


Asp Val Ala Thr Val Leu Arg His Cys His Glu Trp Arg Val Pro Val 
65                  70                  75                  80  


Val Ala Phe Gly Ala Gly Thr Ser Val Glu Gly His Val Val Pro Pro 
                85                  90                  95      


Glu Gln Ala Ile Ser Leu Asp Leu Ser Arg Met Thr Gly Ile Val Asp 
            100                 105                 110         


Leu Asn Ala Glu Asp Leu Asp Cys Arg Val Gln Ala Gly Ile Thr Arg 
        115                 120                 125             


Gln Thr Leu Asn Val Glu Ile Arg Asp Thr Gly Leu Phe Phe Pro Val 
    130                 135                 140                 


Asp Pro Gly Gly Glu Ala Thr Ile Gly Gly Met Cys Ala Thr Arg Ala 
145                 150                 155                 160 


Ser Gly Thr Ala Ala Val Arg Tyr Gly Thr Met Lys Glu Asn Val Leu 
                165                 170                 175     


Gly Leu Thr Val Val Leu Ala Thr Gly Glu Ile Ile Arg Thr Gly Gly 
            180                 185                 190         


Arg Val Arg Lys Ser Ser Thr Gly Tyr Asp Leu Thr Ser Leu Phe Val 
        195                 200                 205             


Gly Ser Glu Gly Thr Leu Gly Ile Ile Thr Glu Val Gln Leu Arg Leu 
    210                 215                 220                 


His Gly Arg Pro Asp Ser Val Ser Ala Ala Ile Cys Gln Phe Glu Ser 
225                 230                 235                 240 


Leu His Asp Ala Ile Gln Thr Ala Met Glu Ile Ile Gln Cys Gly Ile 
                245                 250                 255     


Pro Ile Thr Arg Val Glu Leu Met Asp Ser Val Gln Met Ala Ala Ser 
            260                 265                 270         


Ile Gln Tyr Ser Gly Leu Asn Glu Tyr Gln Pro Leu Thr Thr Leu Phe 
        275                 280                 285             


Phe Glu Phe Thr Gly Ser Pro Ala Ala Val Arg Glu Gln Val Glu Thr 
    290                 295                 300                 


Thr Glu Ala Ile Ala Ser Gly Asn Asn Gly Leu Gly Phe Ala Trp Ala 
305                 310                 315                 320 


Glu Ser Pro Glu Asp Arg Thr Arg Leu Trp Lys Ala Arg His Asp Ala 
                325                 330                 335     


Tyr Trp Ala Ala Lys Ala Ile Val Pro Asp Ala Arg Val Ile Ser Thr 
            340                 345                 350         


Asp Cys Ile Val Pro Ile Ser Arg Leu Gly Glu Leu Ile Glu Gly Val 
        355                 360                 365             


His Arg Asp Ile Glu Ala Ser Gly Leu Arg Ala Pro Leu Leu Gly His 
    370                 375                 380                 


Val Gly Asp Gly Asn Phe His Thr Leu Ile Ile Thr Asp Asp Thr Pro 
385                 390                 395                 400 


Glu Gly His Gln Gln Ala Leu Asp Leu Asp Arg Lys Ile Val Ala Arg 
                405                 410                 415     


Ala Leu Ser Leu Asn Gly Ser Cys Ser Gly Glu His Gly Val Gly Met 
            420                 425                 430         


Gly Lys Leu Glu Phe Leu Glu Thr Glu His Gly Pro Gly Ser Leu Ser 
        435                 440                 445             


Val Met Arg Ala Leu Lys Asn Thr Met Asp Pro His His Ile Leu Asn 
    450                 455                 460                 


Pro Gly Lys Leu Leu Pro Pro Gly Ala Val Tyr Thr Gly 
465                 470                 475         


<210>  207
<211>  433
<212>  PRT
<213>  Caenorhabditis elegans

<400>  207

Met Leu Asn Arg Gly Thr Phe Gln Val Phe Arg Gly Ile Ser Gly Pro 
1               5                   10                  15      


Pro Lys Lys Ser Val Asp Leu Pro Lys Tyr Asp Leu Val Ile Val Gly 
            20                  25                  30          


Gly Gly Ile Val Gly Cys Ala Thr Ala Arg Gln Leu Leu Ile Glu Lys 
        35                  40                  45              


Pro Gln Leu Lys Val Ala Leu Ile Glu Lys Glu Lys Glu Leu Ala Val 
    50                  55                  60                  


His Gln Ser Gly His Asn Ser Gly Val Ile His Ala Gly Ile Tyr Tyr 
65                  70                  75                  80  


Thr Pro Gly Ser Leu Lys Ala Lys Leu Cys Val Glu Gly Leu Asp Leu 
                85                  90                  95      


Ser Tyr Glu Phe Phe Asp Lys Glu Lys Val Pro Tyr Lys Lys Thr Gly 
            100                 105                 110         


Lys Leu Ile Val Ala Val Glu Pro Glu Glu Val Pro Arg Leu Asp Ala 
        115                 120                 125             


Leu Phe Ser Arg Ala Gln Thr Asn Gly Cys Arg Asp Ile Glu Met Ile 
    130                 135                 140                 


Asp Ser Ser Lys Ile Thr Glu Leu Glu Pro His Cys Arg Gly Leu Lys 
145                 150                 155                 160 


Ala Leu Trp Ser Pro His Thr Gly Ile Val Asp Trp Gly Tyr Val Thr 
                165                 170                 175     


Lys Arg Phe Gly Glu Asp Phe Glu Lys Arg Gly Gly Lys Ile Tyr Thr 
            180                 185                 190         


Ser Tyr Pro Leu Glu Lys Ile Ser Asp Asn His Asp Pro Gly Tyr Pro 
        195                 200                 205             


Ile Arg Val Ser Ser Gly Pro Ala Leu Ala Glu Phe Glu Thr Lys Asn 
    210                 215                 220                 


Leu Ile Thr Cys Ala Gly Leu Gln Ser Asp Arg Val Ala Ala Leu Ser 
225                 230                 235                 240 


Gly Cys Ser Thr Asp Pro Lys Ile Val Pro Phe Arg Gly Glu Tyr Leu 
                245                 250                 255     


Leu Leu Lys Pro Glu Lys Arg His Leu Val Lys Thr Asn Ile Tyr Pro 
            260                 265                 270         


Val Pro Asp Pro Arg Phe Pro Phe Leu Gly Val His Phe Thr Pro Arg 
        275                 280                 285             


Met Asn Gly Asp Ile Trp Leu Gly Pro Asn Ala Val Leu Ala Tyr Lys 
    290                 295                 300                 


Arg Glu Gly Tyr Ser Tyr Phe Ser Ile Ser Pro Ser Asp Leu Leu Glu 
305                 310                 315                 320 


Ser Leu Ser Tyr Ser Gly Met Gln Lys Leu Val Lys Lys His Phe Thr 
                325                 330                 335     


Phe Gly Ile Lys Glu Leu Tyr Arg Gly Val Trp Ile Ala Ala Gln Val 
            340                 345                 350         


Lys Gln Leu Gln Arg Phe Ile Pro Glu Leu Lys Leu Ser Asp Val Thr 
        355                 360                 365             


Arg Gly Pro Ala Gly Val Arg Ala Gln Ala Met Asp Ser Ala Gly Asn 
    370                 375                 380                 


Leu Val Asp Asp Phe Val Phe Asp Ser Gly Thr Gly Lys Leu Ser Pro 
385                 390                 395                 400 


Leu Leu Met His Val Arg Asn Ala Pro Ser Pro Ala Ala Thr Ser Ser 
                405                 410                 415     


Leu Ala Ile Ala Lys Met Ile Thr Ser Glu Ala Ile Asn Arg Phe Lys 
            420                 425                 430         


Leu 
    


<210>  208
<211>  455
<212>  PRT
<213>  Drosophila melanogaster

<400>  208

Met Ala Gln Val Arg Leu Leu Val Gln Gly Leu Arg Arg Ser Leu Leu 
1               5                   10                  15      


Asn Val Gly Val Ala Ala Pro Asn Glu Ser Thr Ala Thr His Lys Arg 
            20                  25                  30          


Ser Gln His Ser Ser Ser Ser Cys Gly Asp Tyr Asp Leu Val Val Val 
        35                  40                  45              


Gly Gly Gly Ile Val Gly Ala Ala Ser Ala Arg Glu Ile Val Leu Arg 
    50                  55                  60                  


His Pro Ser Leu Lys Val Ala Val Leu Glu Lys Glu Cys Lys Leu Ala 
65                  70                  75                  80  


Lys His Gln Ser Gly His Asn Ser Gly Val Ile His Ala Gly Ile Tyr 
                85                  90                  95      


Tyr Lys Pro Gly Thr Leu Lys Ala Arg Leu Cys Val Glu Gly Met His 
            100                 105                 110         


Leu Ala Tyr Ala Tyr Leu Asp Glu Lys Lys Ile Pro Tyr Lys Lys Thr 
        115                 120                 125             


Gly Lys Leu Ile Val Ala Thr Asp Glu Lys Glu Val Lys Leu Leu Lys 
    130                 135                 140                 


Asp Leu Glu Lys Arg Gly Ile Ala Asn Asn Val Pro Asp Leu Arg Met 
145                 150                 155                 160 


Ile Glu Gly Ser Glu Ile Gln Glu Ile Glu Pro Tyr Cys Gln Gly Val 
                165                 170                 175     


Met Ala Leu His Ser Pro His Thr Gly Ile Val Asp Trp Gly Leu Val 
            180                 185                 190         


Thr Glu His Tyr Gly Gln Asp Phe Lys Gln Cys Gly Gly Asp Ile Tyr 
        195                 200                 205             


Leu Asp Phe Asn Val Ser Lys Phe Thr Glu Thr Lys Glu Gly Thr Asp 
    210                 215                 220                 


Tyr Pro Val Thr Ile His Gly Ala Lys Pro Gly Gln Thr Val Arg Thr 
225                 230                 235                 240 


Lys Asn Val Leu Thr Cys Gly Gly Leu Gln Ser Asp Leu Leu Ala Glu 
                245                 250                 255     


Lys Thr Gly Cys Pro Arg Asp Pro Arg Ile Val Pro Phe Arg Gly Glu 
            260                 265                 270         


Tyr Leu Leu Leu Thr Lys Glu Lys Gln His Met Val Lys Gly Asn Ile 
        275                 280                 285             


Tyr Pro Val Pro Asp Pro Arg Phe Pro Phe Leu Gly Val His Phe Thr 
    290                 295                 300                 


Pro Arg Met Asp Gly Ser Ile Trp Leu Gly Pro Asn Ala Val Leu Ala 
305                 310                 315                 320 


Leu Lys Arg Glu Gly Tyr Thr Trp Gly Asp Ile Asn Leu Phe Glu Leu 
                325                 330                 335     


Phe Asp Ala Leu Arg Tyr Pro Gly Phe Val Lys Met Ala Ser Lys Tyr 
            340                 345                 350         


Ile Gly Phe Gly Leu Ser Glu Met Ser Lys Ser Trp Phe Ile Asn Leu 
        355                 360                 365             


Gln Ile Lys Ala Leu Gln Lys Tyr Ile Pro Asp Ile Thr Glu Tyr Asp 
    370                 375                 380                 


Ile Gln Arg Gly Pro Ala Gly Val Arg Ala Gln Ala Met Asp Leu Asp 
385                 390                 395                 400 


Gly Asn Leu Val Asp Asp Phe Val Phe Asp Arg Gly Gln Gly Ser Gly 
                405                 410                 415     


Ala Leu Ala Lys Arg Val Leu His Cys Arg Asn Ala Pro Ser Pro Gly 
            420                 425                 430         


Ala Thr Ser Ser Leu Ala Ile Ala Lys Met Ile Ala Asp Lys Ile Glu 
        435                 440                 445             


Asn Glu Phe Ser Ile Gly Lys 
    450                 455 


<210>  209
<211>  321
<212>  PRT
<213>  Bacillus subtilis

<400>  209

Met Met Asn Lys His Val Asn Lys Val Ala Leu Ile Gly Ala Gly Phe 
1               5                   10                  15      


Val Gly Ser Ser Tyr Ala Phe Ala Leu Ile Asn Gln Gly Ile Thr Asp 
            20                  25                  30          


Glu Leu Val Val Ile Asp Val Asn Lys Glu Lys Ala Met Gly Asp Val 
        35                  40                  45              


Met Asp Leu Pro His Gly Lys Ala Phe Gly Leu Gln Pro Val Lys Thr 
    50                  55                  60                  


Ser Tyr Gly Thr Tyr Glu Asp Cys Lys Asp Ala Asp Ile Val Cys Ile 
65                  70                  75                  80  


Cys Ala Gly Ala Asn Gln Lys Pro Gly Glu Thr Arg Leu Glu Leu Val 
                85                  90                  95      


Glu Lys Asn Leu Lys Ile Phe Lys Gly Ile Val Ser Glu Val Met Ala 
            100                 105                 110         


Ser Gly Phe Asp Gly Ile Phe Leu Val Ala Thr Asn Pro Val Asp Ile 
        115                 120                 125             


Leu Thr Tyr Ala Thr Trp Lys Phe Ser Gly Leu Pro Lys Glu Arg Val 
    130                 135                 140                 


Ile Gly Ser Gly Thr Thr Leu Asp Ser Ala Arg Phe Arg Phe Met Leu 
145                 150                 155                 160 


Ser Glu Tyr Phe Gly Ala Ala Pro Gln Asn Val His Ala His Ile Ile 
                165                 170                 175     


Gly Glu His Gly Asp Thr Glu Leu Pro Val Trp Ser His Ala Asn Val 
            180                 185                 190         


Gly Gly Val Pro Val Ser Glu Leu Val Glu Lys Asn Asp Ala Tyr Lys 
        195                 200                 205             


Gln Glu Glu Leu Asp Gln Ile Val Asp Asp Val Lys Asn Ala Ala Tyr 
    210                 215                 220                 


His Ile Ile Glu Lys Lys Gly Ala Thr Tyr Tyr Gly Val Ala Met Ser 
225                 230                 235                 240 


Leu Ala Arg Ile Thr Lys Ala Ile Leu His Asn Glu Asn Ser Ile Leu 
                245                 250                 255     


Thr Val Ser Thr Tyr Leu Asp Gly Gln Tyr Gly Ala Asp Asp Val Tyr 
            260                 265                 270         


Ile Gly Val Pro Ala Val Val Asn Arg Gly Gly Ile Ala Gly Ile Thr 
        275                 280                 285             


Glu Leu Asn Leu Asn Glu Lys Glu Lys Glu Gln Phe Leu His Ser Ala 
    290                 295                 300                 


Gly Val Leu Lys Asn Ile Leu Lys Pro His Phe Ala Glu Gln Lys Val 
305                 310                 315                 320 


Asn 
    


<210>  210
<211>  342
<212>  PRT
<213>  Pseudomonas putida

<400>  210

Met Thr His Pro Arg His Ala Leu Gln Arg Ser Ser Thr Met Arg Ala 
1               5                   10                  15      


Leu Leu Phe Ser Ser Gln His Tyr Asp Gln Glu Ser Phe Thr Lys Ala 
            20                  25                  30          


Ala Gly Gly Thr Ala Leu Glu Leu His Phe Gln Pro Ala Arg Leu Thr 
        35                  40                  45              


Leu Asp Thr Ala Ala Leu Ala Asp Gly Phe Glu Val Val Cys Ala Phe 
    50                  55                  60                  


Ile Asn Asp Glu Leu Asp Ala Pro Val Leu Gln Arg Leu Ala Ala Ala 
65                  70                  75                  80  


Gly Thr Arg Leu Ile Ala Leu Arg Ser Ala Gly Tyr Asn His Val Asp 
                85                  90                  95      


Leu Ala Ala Ala Gln Arg Leu Gly Leu Ala Val Val Arg Val Pro Ala 
            100                 105                 110         


Tyr Ser Pro His Ala Val Ala Glu His Ala Val Ala Leu Ile Leu Ala 
        115                 120                 125             


Leu Asn Arg Arg Leu His Arg Ala Tyr Asn Arg Thr Arg Glu Gly Asp 
    130                 135                 140                 


Phe Thr Leu His Gly Leu Thr Gly Phe Asp Leu His Gly Lys Thr Val 
145                 150                 155                 160 


Gly Val Val Gly Thr Gly Gln Ile Gly Val Ala Phe Ala Arg Ile Met 
                165                 170                 175     


Ala Gly Phe Gly Cys Gln Leu Leu Ala Tyr Asp Pro Tyr Pro Asn Pro 
            180                 185                 190         


Glu Leu Leu Ala Leu Gly Ala Arg Tyr Leu Pro Leu Pro Glu Leu Leu 
        195                 200                 205             


Arg Glu Ala Arg Ile Ile Ser Leu His Cys Pro Leu Thr Glu His Thr 
    210                 215                 220                 


Arg His Leu Ile Asn Ala Gln Ser Leu Ala Gln Leu Gln Pro Gly Ala 
225                 230                 235                 240 


Met Leu Ile Asn Thr Gly Arg Gly Ala Leu Val Asp Thr Pro Ala Leu 
                245                 250                 255     


Ile Asp Ala Leu Lys Ser Gly Gln Leu Gly Tyr Leu Gly Leu Asp Val 
            260                 265                 270         


Tyr Glu Glu Glu Ala Gln Leu Phe Phe Glu Asp Arg Ser Asp Leu Pro 
        275                 280                 285             


Leu Gln Asp Asp Val Leu Ala Arg Leu Leu Thr Phe Pro Asn Val Ile 
    290                 295                 300                 


Ile Thr Ala His Gln Ala Phe Leu Thr Arg Glu Ala Leu Asp Ala Ile 
305                 310                 315                 320 


Ala Ala Thr Thr Leu Asp Asn Ile Asn Arg Trp Ala Ala Gly Asn Pro 
                325                 330                 335     


Gln Asn Leu Val Met Gly 
            340         


