                         SEQUENCE LISTING

<110>  Cytos Biotechnology AG
       Bachmann, Martin
       Spohn, Gunther
 
<120>  USE OF INTERLEUKIN-1 BETA MUTEIN CONJUGATES IN THE TREATMENT OF 
       DIABETES

<130>  P1104PC00

<150>  EP 09169989.2
<151>  2009-09-10

<160>  21    

<170>  PatentIn version 3.3

<210>  1
<211>  569
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Lys Val Leu Leu Arg Leu Ile Cys Phe Ile Ala Leu Leu Ile Ser 
1               5                   10                  15      


Ser Leu Glu Ala Asp Lys Cys Lys Glu Arg Glu Glu Lys Ile Ile Leu 
            20                  25                  30          


Val Ser Ser Ala Asn Glu Ile Asp Val Arg Pro Cys Pro Leu Asn Pro 
        35                  40                  45              


Asn Glu His Lys Gly Thr Ile Thr Trp Tyr Lys Asp Asp Ser Lys Thr 
    50                  55                  60                  


Pro Val Ser Thr Glu Gln Ala Ser Arg Ile His Gln His Lys Glu Lys 
65                  70                  75                  80  


Leu Trp Phe Val Pro Ala Lys Val Glu Asp Ser Gly His Tyr Tyr Cys 
                85                  90                  95      


Val Val Arg Asn Ser Ser Tyr Cys Leu Arg Ile Lys Ile Ser Ala Lys 
            100                 105                 110         


Phe Val Glu Asn Glu Pro Asn Leu Cys Tyr Asn Ala Gln Ala Ile Phe 
        115                 120                 125             


Lys Gln Asn Leu Pro Val Ala Gly Asp Gly Gly Leu Val Cys Pro Tyr 
    130                 135                 140                 


Met Glu Phe Phe Lys Asn Glu Asn Asn Glu Leu Pro Lys Leu Gln Trp 
145                 150                 155                 160 


Tyr Lys Asp Cys Lys Pro Leu Leu Leu Asp Asn Ile His Phe Ser Gly 
                165                 170                 175     


Val Lys Asp Arg Leu Ile Val Met Asn Val Ala Glu Lys His Arg Gly 
            180                 185                 190         


Asn Tyr Thr Cys His Ala Ser Tyr Thr Tyr Leu Gly Lys Gln Tyr Pro 
        195                 200                 205             


Ile Thr Arg Val Ile Glu Phe Ile Thr Leu Glu Glu Asn Lys Pro Thr 
    210                 215                 220                 


Arg Pro Val Ile Val Ser Pro Ala Asn Glu Thr Met Glu Val Asp Leu 
225                 230                 235                 240 


Gly Ser Gln Ile Gln Leu Ile Cys Asn Val Thr Gly Gln Leu Ser Asp 
                245                 250                 255     


Ile Ala Tyr Trp Lys Trp Asn Gly Ser Val Ile Asp Glu Asp Asp Pro 
            260                 265                 270         


Val Leu Gly Glu Asp Tyr Tyr Ser Val Glu Asn Pro Ala Asn Lys Arg 
        275                 280                 285             


Arg Ser Thr Leu Ile Thr Val Leu Asn Ile Ser Glu Ile Glu Ser Arg 
    290                 295                 300                 


Phe Tyr Lys His Pro Phe Thr Cys Phe Ala Lys Asn Thr His Gly Ile 
305                 310                 315                 320 


Asp Ala Ala Tyr Ile Gln Leu Ile Tyr Pro Val Thr Asn Phe Gln Lys 
                325                 330                 335     


His Met Ile Gly Ile Cys Val Thr Leu Thr Val Ile Ile Val Cys Ser 
            340                 345                 350         


Val Phe Ile Tyr Lys Ile Phe Lys Ile Asp Ile Val Leu Trp Tyr Arg 
        355                 360                 365             


Asp Ser Cys Tyr Asp Phe Leu Pro Ile Lys Ala Ser Asp Gly Lys Thr 
    370                 375                 380                 


Tyr Asp Ala Tyr Ile Leu Tyr Pro Lys Thr Val Gly Glu Gly Ser Thr 
385                 390                 395                 400 


Ser Asp Cys Asp Ile Phe Val Phe Lys Val Leu Pro Glu Val Leu Glu 
                405                 410                 415     


Lys Gln Cys Gly Tyr Lys Leu Phe Ile Tyr Gly Arg Asp Asp Tyr Val 
            420                 425                 430         


Gly Glu Asp Ile Val Glu Val Ile Asn Glu Asn Val Lys Lys Ser Arg 
        435                 440                 445             


Arg Leu Ile Ile Ile Leu Val Arg Glu Thr Ser Ser Phe Ser Trp Leu 
    450                 455                 460                 


Gly Gly Ser Ser Glu Glu Gln Ile Ala Met Tyr Asn Ala Leu Val Gln 
465                 470                 475                 480 


Asp Gly Ile Lys Val Val Leu Leu Glu Leu Glu Lys Ile Gln Asp Tyr 
                485                 490                 495     


Glu Lys Met Pro Glu Ser Ile Lys Phe Ile Lys Gln Lys His Gly Ala 
            500                 505                 510         


Ile Arg Trp Ser Gly Asp Phe Thr Gln Gly Pro Gln Ser Ala Lys Thr 
        515                 520                 525             


Arg Phe Trp Lys Asn Val Arg Tyr His Met Pro Val Gln Arg Arg Ser 
    530                 535                 540                 


Pro Ser Ser Lys His Gln Leu Leu Ser Pro Ala Thr Lys Glu Lys Leu 
545                 550                 555                 560 


Gln Arg Glu Ala His Val Pro Leu Gly 
                565                 


<210>  2
<211>  398
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Arg Leu Tyr Val Leu Val Met Gly Val Ser Ala Phe Thr Leu 
1               5                   10                  15      


Gln Pro Ala Ala His Thr Gly Ala Ala Arg Ser Cys Arg Phe Arg Gly 
            20                  25                  30          


Arg His Tyr Lys Arg Glu Phe Arg Leu Glu Gly Glu Pro Val Ala Leu 
        35                  40                  45              


Arg Cys Pro Gln Val Pro Tyr Trp Leu Trp Ala Ser Val Ser Pro Arg 
    50                  55                  60                  


Ile Asn Leu Thr Trp His Lys Asn Asp Ser Ala Arg Thr Val Pro Gly 
65                  70                  75                  80  


Glu Glu Glu Thr Arg Met Trp Ala Gln Asp Gly Ala Leu Trp Leu Leu 
                85                  90                  95      


Pro Ala Leu Gln Glu Asp Ser Gly Thr Tyr Val Cys Thr Thr Arg Asn 
            100                 105                 110         


Ala Ser Tyr Cys Asp Lys Met Ser Ile Glu Leu Arg Val Phe Glu Asn 
        115                 120                 125             


Thr Asp Ala Phe Leu Pro Phe Ile Ser Tyr Pro Gln Ile Leu Thr Leu 
    130                 135                 140                 


Ser Thr Ser Gly Val Leu Val Cys Pro Asp Leu Ser Glu Phe Thr Arg 
145                 150                 155                 160 


Asp Lys Thr Asp Val Lys Ile Gln Trp Tyr Lys Asp Ser Leu Leu Leu 
                165                 170                 175     


Asp Lys Asp Asn Glu Lys Phe Leu Ser Val Arg Gly Thr Thr His Leu 
            180                 185                 190         


Leu Val His Asp Val Ala Leu Glu Asp Ala Gly Tyr Tyr Arg Cys Val 
        195                 200                 205             


Leu Thr Phe Ala His Glu Gly Gln Gln Tyr Asn Ile Thr Arg Ser Ile 
    210                 215                 220                 


Glu Leu Arg Ile Lys Lys Lys Lys Glu Glu Thr Ile Pro Val Ile Ile 
225                 230                 235                 240 


Ser Pro Leu Lys Thr Ile Ser Ala Ser Leu Gly Ser Arg Leu Thr Ile 
                245                 250                 255     


Pro Cys Lys Val Phe Leu Gly Thr Gly Thr Pro Leu Thr Thr Met Leu 
            260                 265                 270         


Trp Trp Thr Ala Asn Asp Thr His Ile Glu Ser Ala Tyr Pro Gly Gly 
        275                 280                 285             


Arg Val Thr Glu Gly Pro Arg Gln Glu Tyr Ser Glu Asn Asn Glu Asn 
    290                 295                 300                 


Tyr Ile Glu Val Pro Leu Ile Phe Asp Pro Val Thr Arg Glu Asp Leu 
305                 310                 315                 320 


His Met Asp Phe Lys Cys Val Val His Asn Thr Leu Ser Phe Gln Thr 
                325                 330                 335     


Leu Arg Thr Thr Val Lys Glu Ala Ser Ser Thr Phe Ser Trp Gly Ile 
            340                 345                 350         


Val Leu Ala Pro Leu Ser Leu Ala Phe Leu Val Leu Gly Gly Ile Trp 
        355                 360                 365             


Met His Arg Arg Cys Lys His Arg Thr Gly Lys Ala Asp Gly Leu Thr 
    370                 375                 380                 


Val Leu Trp Pro His His Gln Asp Phe Gln Ser Tyr Pro Lys 
385                 390                 395             


<210>  3
<211>  132
<212>  PRT
<213>  bacteriophage Qbeta

<400>  3

Ala Lys Leu Glu Thr Val Thr Leu Gly Asn Ile Gly Lys Asp Gly Lys 
1               5                   10                  15      


Gln Thr Leu Val Leu Asn Pro Arg Gly Val Asn Pro Thr Asn Gly Val 
            20                  25                  30          


Ala Ser Leu Ser Gln Ala Gly Ala Val Pro Ala Leu Glu Lys Arg Val 
        35                  40                  45              


Thr Val Ser Val Ser Gln Pro Ser Arg Asn Arg Lys Asn Tyr Lys Val 
    50                  55                  60                  


Gln Val Lys Ile Gln Asn Pro Thr Ala Cys Thr Ala Asn Gly Ser Cys 
65                  70                  75                  80  


Asp Pro Ser Val Thr Arg Gln Ala Tyr Ala Asp Val Thr Phe Ser Phe 
                85                  90                  95      


Thr Gln Tyr Ser Thr Asp Glu Glu Arg Ala Phe Val Arg Thr Glu Leu 
            100                 105                 110         


Ala Ala Leu Leu Ala Ser Pro Leu Leu Ile Asp Ala Ile Asp Gln Leu 
        115                 120                 125             


Asn Pro Ala Tyr 
    130         


<210>  4
<211>  153
<212>  PRT
<213>  Homo sapiens

<400>  4

Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp Ser Gln Gln Lys 
1               5                   10                  15      


Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala Leu His Leu Gln 
            20                  25                  30          


Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met Ser Phe Val Gln 
        35                  40                  45              


Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu Lys Glu 
    50                  55                  60                  


Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro Thr Leu 
65                  70                  75                  80  


Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met Glu 
                85                  90                  95      


Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu Glu Phe 
            100                 105                 110         


Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr Ser Gln Ala Glu 
        115                 120                 125             


Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly Gln Asp Ile Thr 
    130                 135                 140                 


Asp Phe Thr Met Gln Phe Val Ser Ser 
145                 150             


<210>  5
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  chemically synthesized

<400>  5

Met Asp Ile 
1           


<210>  6
<211>  155
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Asp Ile Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp Ser Gln 
1               5                   10                  15      


Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala Leu His 
            20                  25                  30          


Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met Ser Phe 
        35                  40                  45              


Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu 
    50                  55                  60                  


Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro 
65                  70                  75                  80  


Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys 
                85                  90                  95      


Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu 
            100                 105                 110         


Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr Ser Gln 
        115                 120                 125             


Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly Gln Asp 
    130                 135                 140                 


Ile Thr Lys Phe Thr Met Gln Phe Val Ser Ser 
145                 150                 155 


<210>  7
<211>  4
<212>  PRT
<213>  artificial sequence

<220>
<223>  chemically synthesized

<400>  7

Gly Gly Cys Gly 
1               


<210>  8
<211>  3
<212>  PRT
<213>  artificial sequence

<220>
<223>  chemically synthisized

<400>  8

Gly Gly Cys 
1           


<210>  9
<211>  12
<212>  PRT
<213>  artificial sequence

<220>
<223>  chemically synthesized

<400>  9

Leu Glu His His His His His His Gly Gly Cys Gly 
1               5                   10          


<210>  10
<211>  11
<212>  PRT
<213>  artificial sequence

<220>
<223>  chemically synthesized

<400>  10

Leu Glu His His His His His His Gly Gly Cys 
1               5                   10      


<210>  11
<211>  167
<212>  PRT
<213>  Homo sapiens

<400>  11

Met Asp Ile Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp Ser Gln 
1               5                   10                  15      


Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala Leu His 
            20                  25                  30          


Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met Ser Phe 
        35                  40                  45              


Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu 
    50                  55                  60                  


Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro 
65                  70                  75                  80  


Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys 
                85                  90                  95      


Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu 
            100                 105                 110         


Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr Ser Gln 
        115                 120                 125             


Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly Gln Asp 
    130                 135                 140                 


Ile Thr Lys Phe Thr Met Gln Phe Val Ser Ser Leu Glu His His His 
145                 150                 155                 160 


His His His Gly Gly Cys Gly 
                165         


<210>  12
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asp Ile Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp Ser Gln 
1               5                   10                  15      


Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala Leu His 
            20                  25                  30          


Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met Ser Phe 
        35                  40                  45              


Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu 
    50                  55                  60                  


Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro 
65                  70                  75                  80  


Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys 
                85                  90                  95      


Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu 
            100                 105                 110         


Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr Ser Gln 
        115                 120                 125             


Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly Gln Asp 
    130                 135                 140                 


Ile Thr Lys Phe Thr Met Gln Phe Val Ser Ser Leu Glu His His His 
145                 150                 155                 160 


His His His Gly Gly Cys 
                165     


<210>  13
<211>  159
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Asp Ile Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp Ser Gln 
1               5                   10                  15      


Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala Leu His 
            20                  25                  30          


Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met Ser Phe 
        35                  40                  45              


Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu 
    50                  55                  60                  


Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro 
65                  70                  75                  80  


Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys 
                85                  90                  95      


Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu 
            100                 105                 110         


Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr Ser Gln 
        115                 120                 125             


Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly Gln Asp 
    130                 135                 140                 


Ile Thr Lys Phe Thr Met Gln Phe Val Ser Ser Gly Gly Cys Gly 
145                 150                 155                 


<210>  14
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Asp Ile Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp Ser Gln 
1               5                   10                  15      


Gln Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala Leu His 
            20                  25                  30          


Leu Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met Ser Phe 
        35                  40                  45              


Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu 
    50                  55                  60                  


Lys Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro 
65                  70                  75                  80  


Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys 
                85                  90                  95      


Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu 
            100                 105                 110         


Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr Ser Gln 
        115                 120                 125             


Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly Gln Asp 
    130                 135                 140                 


Ile Thr Lys Phe Thr Met Gln Phe Val Ser Ser Gly Gly Cys 
145                 150                 155             


<210>  15
<211>  36
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized

<400>  15
atatatgata tccccattag acagctgcac tacagg                               36


<210>  16
<211>  37
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized

<400>  16
atatatctcg agggaagaca cagattccat ggtgaag                              37


<210>  17
<211>  165
<212>  PRT
<213>  Mus musculus

<400>  17

Met Asp Ile Pro Ile Arg Gln Leu His Tyr Arg Leu Arg Asp Glu Gln 
1               5                   10                  15      


Gln Lys Ser Leu Val Leu Ser Asp Pro Tyr Glu Leu Lys Ala Leu His 
            20                  25                  30          


Leu Asn Gly Gln Asn Ile Asn Gln Gln Val Ile Phe Ser Met Ser Phe 
        35                  40                  45              


Val Gln Gly Glu Pro Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu 
    50                  55                  60                  


Lys Gly Lys Asn Leu Tyr Leu Ser Cys Val Met Lys Asp Gly Thr Pro 
65                  70                  75                  80  


Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Gln Tyr Pro Lys Lys Lys 
                85                  90                  95      


Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Val Lys Ser Lys Val 
            100                 105                 110         


Glu Phe Glu Ser Ala Glu Phe Pro Asn Trp Tyr Ile Ser Thr Ser Gln 
        115                 120                 125             


Ala Glu His Lys Pro Val Phe Leu Gly Asn Asn Ser Gly Gln Asp Ile 
    130                 135                 140                 


Ile Lys Phe Thr Met Glu Ser Val Ser Ser Leu Glu His His His His 
145                 150                 155                 160 


His His Gly Gly Cys 
                165 


<210>  18
<211>  42
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized

<400>  18
cagtggtcag gacataatta aattcaccat ggaatctgtg tc                        42


<210>  19
<211>  42
<212>  DNA
<213>  artificial sequence

<220>
<223>  chemically synthesized

<400>  19
gacacagatt ccatggtgaa tttaattatg tcctgaccac tg                        42


<210>  20
<211>  154
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Pro Val Arg Ser Leu Asn Cys Thr Leu Arg Asp Ser Gln Gln 
1               5                   10                  15      


Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala Leu His Leu 
            20                  25                  30          


Gln Gly Gln Asp Met Glu Gln Gln Val Val Phe Ser Met Ser Phe Val 
        35                  40                  45              


Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu Lys 
    50                  55                  60                  


Glu Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro Thr 
65                  70                  75                  80  


Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys Met 
                85                  90                  95      


Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu Glu 
            100                 105                 110         


Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr Ser Gln Ala 
        115                 120                 125             


Glu Asn Met Pro Val Phe Leu Gly Gly Thr Lys Gly Gly Gln Asp Ile 
    130                 135                 140                 


Thr Asp Phe Thr Met Gln Phe Val Ser Ser 
145                 150                 


<210>  21
<211>  167
<212>  PRT
<213>  Macaca mulatta

<400>  21

Met Asp Ile Pro Val Arg Ser Leu His Cys Thr Leu Arg Asp Ala Gln 
1               5                   10                  15      


Leu Lys Ser Leu Val Met Ser Gly Pro Tyr Glu Leu Lys Ala Leu His 
            20                  25                  30          


Leu Gln Gly Gln Asp Leu Glu Gln Gln Val Val Phe Ser Met Ser Phe 
        35                  40                  45              


Val Gln Gly Glu Glu Ser Asn Asp Lys Ile Pro Val Ala Leu Gly Leu 
    50                  55                  60                  


Lys Ala Lys Asn Leu Tyr Leu Ser Cys Val Leu Lys Asp Asp Lys Pro 
65                  70                  75                  80  


Thr Leu Gln Leu Glu Ser Val Asp Pro Lys Asn Tyr Pro Lys Lys Lys 
                85                  90                  95      


Met Glu Lys Arg Phe Val Phe Asn Lys Ile Glu Ile Asn Asn Lys Leu 
            100                 105                 110         


Glu Phe Glu Ser Ala Gln Phe Pro Asn Trp Tyr Ile Ser Thr Ser Gln 
        115                 120                 125             


Ala Glu Asn Met Pro Val Phe Leu Gly Gly Thr Arg Gly Gly Gln Asp 
    130                 135                 140                 


Ile Thr Lys Phe Thr Met Gln Phe Val Ser Ser Leu Glu His His His 
145                 150                 155                 160 


His His His Gly Gly Cys Gly 
                165         


