                         SEQUENCE LISTING

<110>  Case Western Reserve University
 
<120>  INSULIN ANALOGUE WITH ENHANCED RECEPTOR-BINDING SPECIFICITY

<130>  200512.00088

<150>  US 61/238,871
<151>  2009-09-01

<160>  21    

<170>  PatentIn version 3.4

<210>  1
<211>  86
<212>  PRT
<213>  Homo sapiens

<400>  1

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr Arg Arg 
            20                  25                  30          


Glu Ala Glu Asp Leu Gln Val Gly Gln Val Glu Leu Gly Gly Gly Pro 
        35                  40                  45              


Gly Ala Gly Ser Leu Gln Pro Leu Ala Leu Glu Gly Ser Leu Gln Lys 
    50                  55                  60                  


Arg Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln 
65                  70                  75                  80  


Leu Glu Asn Tyr Cys Asn 
                85      


<210>  2
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  2

Gly Ile Val Glu Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  3
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  3

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  4
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  4

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Lys Pro Thr 
            20                  25                  30  


<210>  5
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  5

Phe Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Asp Lys Thr 
            20                  25                  30  


<210>  6
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  6

Phe Val Asn Gln His Leu Cys Gly Ser Asp Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  7
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  7

Phe Val Asn Gln His Leu Cys Gly Ser Asp Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Lys Pro Thr 
            20                  25                  30  


<210>  8
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa=D-Ala, D-Leu, or D-Asp, Phe

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa=His, Lys, Arg, Orn, Dbu, Dpr

<400>  8

Xaa Ile Val Glu Gln Cys Cys Xaa Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  9
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa=Dbu

<400>  9

Phe Ile Val Glu Gln Cys Cys Xaa Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  10
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa=D-Ala

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa=Dbu

<400>  10

Xaa Ile Val Glu Gln Cys Cys Xaa Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  11
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa=D-Leu

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa=Dbu

<400>  11

Xaa Ile Val Glu Gln Cys Cys Xaa Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  12
<211>  21
<212>  PRT
<213>  Homo sapiens


<220>
<221>  MISC_FEATURE
<222>  (1)..(1)
<223>  Xaa=D-Asp

<220>
<221>  MISC_FEATURE
<222>  (8)..(8)
<223>  Xaa=Dbu

<400>  12

Xaa Ile Val Glu Gln Cys Cys Xaa Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  13
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  13

Arg Gly Ile Val Glu Gln Cys Cys Arg Ser Ile Cys Ser Leu Tyr Gln 
1               5                   10                  15      


Leu Glu Asn Tyr Cys Gly 
            20          


<210>  14
<211>  22
<212>  PRT
<213>  Homo sapiens

<400>  14

Arg Gly Ile Val Glu Gln Cys Cys His Ser Ile Cys Ser Leu Tyr Gln 
1               5                   10                  15      


Leu Glu Asn Tyr Cys Gly 
            20          


<210>  15
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  15

Gly Ile Val Glu Gln Cys Cys His Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Gly 
            20      


<210>  16
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  16

Gly Ile Val Ala Gln Cys Cys His Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  17
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  17

Gly Ile Val His Gln Cys Cys His Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  18
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  18

Gly Ile Val Ala Gln Cys Cys His Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Gly 
            20      


<210>  19
<211>  30
<212>  PRT
<213>  Homo sapiens

<400>  19

His Val Asn Gln His Leu Cys Gly Ser His Leu Val Glu Ala Leu Tyr 
1               5                   10                  15      


Leu Val Cys Gly Glu Arg Gly Phe Phe Tyr Thr Pro Lys Thr 
            20                  25                  30  


<210>  20
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  20

Gly Ile Val His Gln Cys Cys Thr Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


<210>  21
<211>  21
<212>  PRT
<213>  Homo sapiens

<400>  21

Gly Ile Val Glu Gln Cys Cys His Ser Ile Cys Ser Leu Tyr Gln Leu 
1               5                   10                  15      


Glu Asn Tyr Cys Asn 
            20      


