                         SEQUENCE LISTING

<110>  Schebye, Xiao-Min
       Ermakov, Grigori
       Hodges, Douglas  J.
       Presta, Leonard  G.
 
<120>  ANTI-GITR ANTIBODIES

<130>  BP2009.6860WO

<150>  61/239,667
<151>  2009-09-03

<150>  61/307,767
<151>  2010-02-24

<150>  61/313,955
<151>  2010-03-15

<160>  111   

<170>  PatentIn version 3.5

<210>  1
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  1

Glu Val Asn Leu Val Glu Ser Gly Gly Gly Leu Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Val Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Thr Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Gly Gly Tyr Tyr Asp Ser Met Asp Tyr Trp Gly Gln Gly Ile 
            100                 105                 110         


Ser Val Thr Asp Ser Ser 
        115             


<210>  2
<211>  123
<212>  PRT
<213>  Rattus norvegicus

<400>  2

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Thr Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile His Ala Asn Gly Gly Ser Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Ser Ile Ser Arg Asp Asn Gly Lys Ser Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asp Ser Leu Arg Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Thr Gly Ser Phe Met Tyr Ala Ala Asp Tyr Tyr Ile Met Asp Ala 
            100                 105                 110         


Trp Gly Gln Gly Ala Ser Val Thr Val Ser Ser 
        115                 120             


<210>  3
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  3

Asp Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Thr Val Thr Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Arg Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Gln Leu Asn Ser Val Thr Ser Glu Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Leu Gly Leu Arg Phe Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Thr Leu Thr Val Ser Ser 
        115             


<210>  4
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  4

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Met Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Ile Glu Trp Ile Lys Gln Arg Pro Gly His Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Ser Ser Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Phe Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Val Tyr Tyr Tyr Ala Met Asp Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  5
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  5

Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Ala Arg Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Ser Val Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Lys Ala Thr Leu Thr Ala Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Tyr Tyr Asp Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  6
<211>  122
<212>  PRT
<213>  Mus musculus

<400>  6

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Phe Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Gln Leu Thr Ile Ser Lys Asp Thr Ser Arg Asn Gln Val 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Ser Leu Asp Thr Ala Asp Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Val Arg Ser Tyr Tyr Tyr Gly Ser Ser Gly Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Ser Val Thr Val Ser Ser 
        115                 120         


<210>  7
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  7

Glu Val Lys Leu Val Glu Ser Gly Gly Gly Phe Val Lys Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Arg Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Thr Pro Glu Lys Arg Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Gly Asp Arg Ser Tyr Leu Pro Asp Ser Met Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Arg Asn Ile Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Ser Ser Leu Arg Ser Glu Asp Thr Ala Ile Tyr Tyr Cys Gln 
                85                  90                  95      


Arg Tyr Phe Asp Phe Asp Ser Phe Ala Phe Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ala 
        115         


<210>  8
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  8

Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Glu Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Arg 
    50                  55                  60                  


Gly Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Ser Gln Tyr Tyr Leu 
65                  70                  75                  80  


Gln Leu Ser Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ser 
                85                  90                  95      


Arg Arg His Leu Gly Ser Gly Tyr Gly Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  9
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  9

Glu Val Gln Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Phe Glu Tyr Met 
        35                  40                  45              


Gly Phe Ile Ser Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser Leu Arg 
    50                  55                  60                  


Ser Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Phe Leu 
65                  70                  75                  80  


His Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ser 
                85                  90                  95      


Arg Arg His Leu Ile Ser Gly Tyr Gly Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ala 
        115                 120 


<210>  10
<211>  121
<212>  PRT
<213>  Rattus norvegicus

<400>  10

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Asn Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Ile His Arg Leu Thr Val Ser Lys Asp Thr Ser Asn Asn Gln Ala 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Asn Val Asp Thr Ala Glu Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Gln Ile Lys Glu Pro Arg Asp Trp Phe Phe Glu Phe Trp Gly 
            100                 105                 110         


Pro Gly Thr Met Val Ser Val Ser Ser 
        115                 120     


<210>  11
<211>  121
<212>  PRT
<213>  Rattus norvegicus

<400>  11

Gln Val Thr Leu Lys Glu Ser Gly Pro Gly Ile Leu Gln Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Phe Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Ser Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Leu Ala Asn Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Asn Arg Leu Thr Ile Ser Lys Asp Thr Ser Asn Asn Gln Ala 
65                  70                  75                  80  


Phe Leu Lys Ile Thr Asn Val Asp Thr Ala Glu Thr Ala Thr Tyr Tyr 
                85                  90                  95      


Cys Ala Gln Ile Lys Glu Pro Arg Asp Trp Phe Phe Glu Phe Trp Gly 
            100                 105                 110         


Pro Gly Thr Met Val Ser Val Ser Ser 
        115                 120     


<210>  12
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  12

Asp Ile Val Leu Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Val Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Met Tyr Phe Cys Gln Gln Thr Lys 
                85                  90                  95      


Glu Val Thr Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Ala 
    


<210>  13
<211>  113
<212>  PRT
<213>  Rattus norvegicus

<400>  13

Asp Val Val Met Thr Gln Thr Pro Val Ser Leu Ser Val Ser Leu Gly 
1               5                   10                  15      


Asn Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asp Gly Asn Thr Phe Leu Ser Trp Tyr Phe Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Ala Ser Asn Arg Phe Ser Gly Val Ser 
    50                  55                  60                  


Asn Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Pro Glu Asp Leu Gly Val Tyr Tyr Cys Phe Gln His 
                85                  90                  95      


Thr His Leu Pro Leu Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  14
<211>  108
<212>  PRT
<213>  Mus musculus

<400>  14

Gln Ile Val Leu Thr Gln Ser Pro Ala Leu Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Asn Ser Thr Val Asn Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Arg Ser Ser Pro Lys Pro Cys Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Arg Arg Ala 
            100                 105             


<210>  15
<211>  110
<212>  PRT
<213>  Mus musculus

<400>  15

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Val Thr Cys Thr Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Phe His Trp Tyr Gln Gln Lys Pro Gly Ser Ser Pro Lys Leu Trp 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Thr Met Glu 
65                  70                  75                  80  


Ala Glu Asp Ala Ala Thr Tyr Tyr Cys His Gln Tyr His Arg Ser Pro 
                85                  90                  95      


Arg Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys Arg Ala 
            100                 105                 110 


<210>  16
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  16

Asp Ile Val Val Thr Gln Ser Pro Ala Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Phe Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Ser Leu Asn Ile His 
65                  70                  75                  80  


Pro Met Glu Glu Asp Asp Thr Ala Val Tyr Phe Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg 
            100                 105                 110         


Ala 
    


<210>  17
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  17

Asp Ile Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Lys Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Ala Asp Ala Ala Pro 
        115             


<210>  18
<211>  113
<212>  PRT
<213>  Mus musculus

<400>  18

Asp Ile Gln Met Thr Gln Thr Pro Ser Ser Leu Ser Ala Ser Leu Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp Ile Asn Asn Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Ser Leu Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Lys Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ser Leu Thr Ile Ser Asn Leu Asp Gln 
65                  70                  75                  80  


Glu Asp Val Ala Thr Tyr Phe Cys Gln Gln Gly His Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Val Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro 
    


<210>  19
<211>  114
<212>  PRT
<213>  Mus musculus

<400>  19

Asp Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Ser Ile Thr Cys Lys Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ala Leu Thr Ile Asn Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Leu Ala Leu Tyr Tyr Cys Gln Gln His Ser Tyr Thr Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Arg Arg Ala Asp Ala 
            100                 105                 110         


Ala Pro 
        


<210>  20
<211>  114
<212>  PRT
<213>  Mus musculus

<400>  20

Val Ile Val Met Thr Gln Ser His Lys Phe Met Ser Thr Ser Ile Gly 
1               5                   10                  15      


Asp Arg Val Asn Ile Thr Cys Lys Ala Ser Gln Asp Val Ile Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Thr Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Asn Ser Val Gln Ala 
65                  70                  75                  80  


Glu Asp Arg Ala Leu Tyr Tyr Cys Gln Gln His Ser Tyr Thr Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gly Gly Thr Asn Leu Glu Ile Lys Arg Ala Asp Ala 
            100                 105                 110         


Ala Pro 
        


<210>  21
<211>  113
<212>  PRT
<213>  Rattus norvegicus

<400>  21

Asp Ile Gln Met Thr Gln Thr Pro Ser Ser Met Pro Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Phe Cys Arg Ala Ser Gln Gly Val Asn Asn Phe 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Lys Pro Asp Gly Thr Ile Lys Pro Leu Ile 
        35                  40                  45              


Phe Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Ser Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln Tyr His Gly Phe Pro Asn 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro 
    


<210>  22
<211>  113
<212>  PRT
<213>  Rattus norvegicus

<400>  22

Asp Ile Gln Met Thr Gln Thr Pro Ser Ser Met Pro Ala Ser Leu Gly 
1               5                   10                  15      


Glu Arg Val Thr Ile Phe Cys Arg Ala Ser Gln Gly Val Asn Asn Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Lys Pro Asp Gly Thr Ile Lys Pro Leu Ile 
        35                  40                  45              


Phe Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Ser Leu Ser Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Met Tyr Tyr Cys Gln Gln Tyr His Gly Phe Pro Asn 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys Arg Ala Asp Ala Ala 
            100                 105                 110         


Pro 
    


<210>  23
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  23

Gly Phe Thr Phe Ser Ser Tyr Ala Met Ser 
1               5                   10  


<210>  24
<211>  10
<212>  PRT
<213>  Rattus norvegicus

<400>  24

Gly Phe Thr Phe Ser Asp Tyr Tyr Met Ala 
1               5                   10  


<210>  25
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  25

Gly Tyr Ser Ile Thr Ser Asp Tyr Ala Trp Asn 
1               5                   10      


<210>  26
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  26

Gly Tyr Thr Phe Ser Arg Tyr Trp Ile Glu 
1               5                   10  


<210>  27
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  27

Gly Tyr Thr Phe Thr Ser Tyr Thr Met His 
1               5                   10  


<210>  28
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  28

Gly Phe Ser Leu Ser Thr Ser Gly Met Gly Val Gly 
1               5                   10          


<210>  29
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  29

Gly Phe Thr Val Arg Asn Tyr Ala Met Ser 
1               5                   10  


<210>  30
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  30

Gly Asp Ser Ile Thr Ser Gly Tyr Trp Asn 
1               5                   10  


<210>  31
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  31

Gly Asp Ser Ile Thr Ser Gly Tyr Trp Asn 
1               5                   10  


<210>  32
<211>  12
<212>  PRT
<213>  Rattus norvegicus

<400>  32

Gly Phe Ser Leu Ser Thr Tyr Gly Val Gly Val Gly 
1               5                   10          


<210>  33
<211>  12
<212>  PRT
<213>  Rattus norvegicus

<400>  33

Gly Phe Ser Leu Ser Thr Tyr Gly Val Gly Val Gly 
1               5                   10          


<210>  34
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  34

Ser Ile Ser Ser Gly Gly Thr Thr Tyr Tyr Pro Asp Ser Val Lys Gly 
1               5                   10                  15      


<210>  35
<211>  17
<212>  PRT
<213>  Rattus norvegicus

<400>  35

Tyr Ile His Ala Asn Gly Gly Ser Thr Tyr Tyr Arg Asp Ser Val Arg 
1               5                   10                  15      


Gly 
    


<210>  36
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  36

Tyr Ile Ser Tyr Ser Gly Ser Thr Arg Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  37
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  37

Glu Ile Leu Pro Gly Ser Gly Ser Ser Asn Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  38
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  38

Tyr Ile Asn Pro Arg Ser Val Tyr Thr Asn Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Asp 
    


<210>  39
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  39

His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Ser Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  40
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  40

Ser Ile Ser Thr Gly Asp Arg Ser Tyr Leu Pro Asp Ser Met Lys Gly 
1               5                   10                  15      


<210>  41
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  41

Tyr Ile Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Arg Gly 
1               5                   10                  15      


<210>  42
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  42

Phe Ile Ser Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser Leu Arg Ser 
1               5                   10                  15      


<210>  43
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  43

Asn Ile Trp Trp Asp Asp Asp Asn Tyr Tyr Asn Pro Ser Leu Ile His 
1               5                   10                  15      


<210>  44
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  44

Asn Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  45
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  45

Val Gly Gly Tyr Tyr Asp Ser Met Asp Tyr 
1               5                   10  


<210>  46
<211>  14
<212>  PRT
<213>  Rattus norvegicus

<400>  46

Gly Ser Phe Met Tyr Ala Ala Asp Tyr Tyr Ile Met Asp Ala 
1               5                   10                  


<210>  47
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  47

Gln Leu Gly Leu Arg Phe Phe Asp Tyr 
1               5                   


<210>  48
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  48

Lys Val Tyr Tyr Tyr Ala Met Asp Phe 
1               5                   


<210>  49
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  49

Leu Gly Gly Tyr Tyr Asp Thr Met Asp Tyr 
1               5                   10  


<210>  50
<211>  23
<212>  PRT
<213>  Mus musculus

<400>  50

Ser Tyr Tyr Tyr Gly Ser Ser Gly Ala Met Asp Tyr Trp Gly Gln Gly 
1               5                   10                  15      


Thr Ser Val Thr Val Ser Ser 
            20              


<210>  51
<211>  20
<212>  PRT
<213>  Mus musculus

<400>  51

Tyr Phe Asp Phe Asp Ser Phe Ala Phe Trp Gly Gln Gly Thr Leu Val 
1               5                   10                  15      


Thr Val Ser Ala 
            20  


<210>  52
<211>  23
<212>  PRT
<213>  Mus musculus

<400>  52

Arg His Leu Gly Ser Gly Tyr Gly Trp Phe Ala Tyr Trp Gly Gln Gly 
1               5                   10                  15      


Thr Leu Val Thr Val Ser Ala 
            20              


<210>  53
<211>  23
<212>  PRT
<213>  Mus musculus

<400>  53

Arg His Leu Ile Ser Gly Tyr Gly Trp Phe Ala Tyr Trp Gly Gln Gly 
1               5                   10                  15      


Thr Leu Val Thr Val Ser Ala 
            20              


<210>  54
<211>  22
<212>  PRT
<213>  Rattus norvegicus

<400>  54

Ile Lys Glu Pro Arg Asp Trp Phe Phe Glu Phe Trp Gly Pro Gly Thr 
1               5                   10                  15      


Met Val Ser Val Ser Ser 
            20          


<210>  55
<211>  22
<212>  PRT
<213>  Rattus norvegicus

<400>  55

Ile Lys Glu Pro Arg Asp Trp Phe Phe Glu Phe Trp Gly Pro Gly Thr 
1               5                   10                  15      


Met Val Ser Val Ser Ser 
            20          


<210>  56
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  56

Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Val Ser Phe Met Asn 
1               5                   10                  15  


<210>  57
<211>  16
<212>  PRT
<213>  Rattus norvegicus

<400>  57

Arg Ser Ser Gln Ser Leu Leu His Ser Asp Gly Asn Thr Phe Leu Ser 
1               5                   10                  15      


<210>  58
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  58

Ser Ala Asn Ser Thr Val Asn Tyr Met Tyr 
1               5                   10  


<210>  59
<211>  12
<212>  PRT
<213>  Mus musculus

<400>  59

Thr Ala Ser Ser Ser Val Ser Ser Ser Tyr Phe His 
1               5                   10          


<210>  60
<211>  15
<212>  PRT
<213>  Mus musculus

<400>  60

Arg Ala Ser Glu Ser Val Asp Asn Tyr Gly Ile Ser Phe Met Asn 
1               5                   10                  15  


<210>  61
<211>  16
<212>  PRT
<213>  Mus musculus

<400>  61

Arg Ser Ser Gln Ser Leu Val His Ser Asp Gly Asn Thr Tyr Leu His 
1               5                   10                  15      


<210>  62
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  62

Arg Ala Ser Gln Asp Ile Asn Asn Phe Leu Asn 
1               5                   10      


<210>  63
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  63

Lys Ala Ser Gln Asp Val Asn Thr Ala Val Ala 
1               5                   10      


<210>  64
<211>  11
<212>  PRT
<213>  Mus musculus

<400>  64

Lys Ala Ser Gln Asp Val Ile Ser Ala Val Ala 
1               5                   10      


<210>  65
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  65

Arg Ala Ser Gln Gly Val Asn Asn Phe Leu Thr 
1               5                   10      


<210>  66
<211>  11
<212>  PRT
<213>  Rattus norvegicus

<400>  66

Arg Ala Ser Gln Gly Val Asn Asn Tyr Leu Thr 
1               5                   10      


<210>  67
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  67

Ala Ala Ser Asn Gln Gly Ser 
1               5           


<210>  68
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  68

Leu Ala Ser Asn Arg Phe Ser 
1               5           


<210>  69
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  69

Leu Thr Ser Asn Leu Ala Ser 
1               5           


<210>  70
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  70

Ser Thr Ser Asn Leu Ala Ser 
1               5           


<210>  71
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  71

Ala Ala Ser Asn Gln Gly Ser 
1               5           


<210>  72
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  72

Lys Val Ser Lys Arg Phe Ser 
1               5           


<210>  73
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  73

Tyr Thr Ser Lys Leu His Ser 
1               5           


<210>  74
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  74

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  75
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  75

Trp Ala Ser Thr Arg His Thr 
1               5           


<210>  76
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  76

Tyr Thr Ser Asn Leu Gln Ser 
1               5           


<210>  77
<211>  7
<212>  PRT
<213>  Rattus norvegicus

<400>  77

Tyr Thr Ser Asn Leu Gln Ser 
1               5           


<210>  78
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  78

Gln Gln Thr Lys Glu Val Thr Trp Thr 
1               5                   


<210>  79
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  79

Phe Gln His Thr His Leu Pro Leu Thr 
1               5                   


<210>  80
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  80

Gln Gln Trp Asn Ser Asn Pro Pro Thr 
1               5                   


<210>  81
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  81

His Gln Tyr His Arg Ser Pro Arg Thr 
1               5                   


<210>  82
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  82

Gln Gln Ser Lys Glu Val Pro Phe Thr 
1               5                   


<210>  83
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  83

Ser Gln Ser Thr His Val Pro Pro Thr 
1               5                   


<210>  84
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  84

Gln Gln Gly His Thr Leu Pro Pro Thr 
1               5                   


<210>  85
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  85

Gln Gln His Ser Tyr Thr Pro Pro Trp Thr 
1               5                   10  


<210>  86
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  86

Gln Gln His Ser Tyr Thr Pro Pro Trp Thr 
1               5                   10  


<210>  87
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  87

Gln Gln Tyr His Gly Phe Pro Asn Thr 
1               5                   


<210>  88
<211>  9
<212>  PRT
<213>  Rattus norvegicus

<400>  88

Gln Gln Tyr His Gly Phe Pro Asn Thr 
1               5                   


<210>  89
<211>  241
<212>  PRT
<213>  Homo sapiens


<220>
<221>  SIGNAL
<222>  (1)..(25)

<400>  89

Met Ala Gln His Gly Ala Met Gly Ala Phe Arg Ala Leu Cys Gly Leu 
1               5                   10                  15      


Ala Leu Leu Cys Ala Leu Ser Leu Gly Gln Arg Pro Thr Gly Gly Pro 
            20                  25                  30          


Gly Cys Gly Pro Gly Arg Leu Leu Leu Gly Thr Gly Thr Asp Ala Arg 
        35                  40                  45              


Cys Cys Arg Val His Thr Thr Arg Cys Cys Arg Asp Tyr Pro Gly Glu 
    50                  55                  60                  


Glu Cys Cys Ser Glu Trp Asp Cys Met Cys Val Gln Pro Glu Phe His 
65                  70                  75                  80  


Cys Gly Asp Pro Cys Cys Thr Thr Cys Arg His His Pro Cys Pro Pro 
                85                  90                  95      


Gly Gln Gly Val Gln Ser Gln Gly Lys Phe Ser Phe Gly Phe Gln Cys 
            100                 105                 110         


Ile Asp Cys Ala Ser Gly Thr Phe Ser Gly Gly His Glu Gly His Cys 
        115                 120                 125             


Lys Pro Trp Thr Asp Cys Thr Gln Phe Gly Phe Leu Thr Val Phe Pro 
    130                 135                 140                 


Gly Asn Lys Thr His Asn Ala Val Cys Val Pro Gly Ser Pro Pro Ala 
145                 150                 155                 160 


Glu Pro Leu Gly Trp Leu Thr Val Val Leu Leu Ala Val Ala Ala Cys 
                165                 170                 175     


Val Leu Leu Leu Thr Ser Ala Gln Leu Gly Leu His Ile Trp Gln Leu 
            180                 185                 190         


Arg Ser Gln Cys Met Trp Pro Arg Glu Thr Gln Leu Leu Leu Glu Val 
        195                 200                 205             


Pro Pro Ser Thr Glu Asp Ala Arg Ser Cys Gln Phe Pro Glu Glu Glu 
    210                 215                 220                 


Arg Gly Glu Arg Ser Ala Glu Glu Lys Gly Arg Leu Gly Asp Leu Trp 
225                 230                 235                 240 


Val 
    


<210>  90
<211>  122
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  humanized antibody sequence


<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  Can be A or F

<220>
<221>  VARIANT
<222>  (69)..(69)
<223>  Can be F or L

<220>
<221>  VARIANT
<222>  (73)..(73)
<223>  Can be R or K

<220>
<221>  VARIANT
<222>  (75)..(75)
<223>  Can be N or T

<220>
<221>  VARIANT
<222>  (80)..(80)
<223>  Can be L or V

<220>
<221>  VARIANT
<222>  (98)..(98)
<223>  Can be A or V

<400>  90

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Xaa Ser Gly Phe Ser Leu Ser Thr Ser 
            20                  25                  30          


Gly Met Gly Val Gly Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Val Ala His Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Ser Pro Ser 
    50                  55                  60                  


Leu Lys Ser Arg Xaa Thr Ile Ser Xaa Asp Xaa Ser Lys Asn Thr Xaa 
65                  70                  75                  80  


Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Xaa Arg Ser Tyr Tyr Tyr Gly Ser Ser Gly Ala Met Asp Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  91
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence

<400>  91

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Ser 
            20                  25                  30          


Asp Gly Asn Thr Tyr Leu His Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Lys Val Ser Lys Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  92
<211>  123
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (97)..(97)
<223>  Can be A or T

<220>
<221>  VARIANT
<222>  (98)..(98)
<223>  Can be R or T

<400>  92

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr 
            20                  25                  30          


Tyr Met Ala Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Tyr Ile His Ala Asn Gly Gly Ser Thr Tyr Tyr Arg Asp Ser Val 
    50                  55                  60                  


Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Xaa Xaa Gly Ser Phe Met Tyr Ala Ala Asp Tyr Tyr Ile Met Asp Ala 
            100                 105                 110         


Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120             


<210>  93
<211>  113
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence

<400>  93

Asp Ile Val Met Thr Gln Ser Pro Leu Ser Leu Pro Val Thr Pro Gly 
1               5                   10                  15      


Glu Pro Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Leu His Ser 
            20                  25                  30          


Asp Gly Asn Thr Phe Leu Ser Trp Tyr Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Gln Leu Leu Ile Tyr Leu Ala Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr Cys Phe Gln His 
                85                  90                  95      


Thr His Leu Pro Leu Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 
            100                 105                 110         


Arg 
    


<210>  94
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (48)..(48)
<223>  Can be M or I

<220>
<221>  VARIANT
<222>  (68)..(68)
<223>  Can be V or A

<220>
<221>  VARIANT
<222>  (70)..(70)
<223>  Can be M or F

<220>
<221>  VARIANT
<222>  (72)..(72)
<223>  Can be T or A

<400>  94

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Ser Arg Tyr 
            20                  25                  30          


Trp Ile Glu Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Xaa 
        35                  40                  45              


Gly Glu Ile Leu Pro Gly Ser Gly Ser Ser Asn Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Asp Arg Xaa Thr Xaa Thr Xaa Asp Thr Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Lys Val Tyr Tyr Tyr Ala Met Asp Phe Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  95
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (48)..(48)
<223>  Can be L or W

<220>
<221>  VARIANT
<222>  (72)..(72)
<223>  Can be F or Y

<400>  95

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Thr Ala Ser Ser Ser Val Ser Ser Ser 
            20                  25                  30          


Tyr Phe His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Xaa 
        35                  40                  45              


Ile Tyr Ser Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Asp Xaa Thr Leu Thr Ile Ser Arg Leu Glu 
65                  70                  75                  80  


Pro Glu Asp Phe Ala Val Tyr Tyr Cys His Gln Tyr His Arg Ser Pro 
                85                  90                  95      


Arg Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 


<210>  96
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  Can be V or F

<220>
<221>  VARIANT
<222>  (50)..(50)
<223>  Can be I or L

<220>
<221>  VARIANT
<222>  (51)..(51)
<223>  Can be G or A

<220>
<221>  VARIANT
<222>  (69)..(69)
<223>  Can be V or L

<220>
<221>  VARIANT
<222>  (71)..(71)
<223>  Can be I or V

<220>
<221>  VARIANT
<222>  (73)..(73)
<223>  Can be V or K

<220>
<221>  VARIANT
<222>  (80)..(80)
<223>  Can be F or A

<220>
<221>  VARIANT
<222>  (99)..(99)
<223>  Can be R or Q

<400>  96

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Xaa Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Xaa Xaa Asn Ile Trp Trp Asp Asp Asp Asn Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Ile His Arg Xaa Thr Xaa Ser Xaa Asp Thr Ser Lys Asn Gln Xaa 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Xaa Ile Lys Glu Pro Arg Asp Trp Phe Phe Glu Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  97
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (46)..(46)
<223>  Can be L or P

<220>
<221>  VARIANT
<222>  (49)..(49)
<223>  Can be Y or F

<220>
<221>  VARIANT
<222>  (71)..(71)
<223>  Can be F or Y

<400>  97

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Asn Asn Phe 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Xaa Leu Ile 
        35                  40                  45              


Xaa Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Xaa Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Gly Phe Pro Asn 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  98
<211>  121
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (24)..(24)
<223>  Can be V or F

<220>
<221>  VARIANT
<222>  (50)..(50)
<223>  Can be I or L

<220>
<221>  VARIANT
<222>  (51)..(51)
<223>  Can be G or A

<220>
<221>  VARIANT
<222>  (69)..(69)
<223>  Can be V or L

<220>
<221>  VARIANT
<222>  (73)..(73)
<223>  Can be V or K

<220>
<221>  VARIANT
<222>  (80)..(80)
<223>  Can be F or A

<220>
<221>  VARIANT
<222>  (99)..(99)
<223>  Can be R or Q

<400>  98

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Xaa Ser Gly Phe Ser Leu Ser Thr Tyr 
            20                  25                  30          


Gly Val Gly Val Gly Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu 
        35                  40                  45              


Trp Xaa Xaa Asn Ile Trp Trp Asp Asp Asp Lys Tyr Tyr Asn Pro Ser 
    50                  55                  60                  


Leu Lys Asn Arg Xaa Thr Ile Ser Xaa Asp Thr Ser Lys Asn Gln Xaa 
65                  70                  75                  80  


Ser Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr 
                85                  90                  95      


Cys Ala Xaa Ile Lys Glu Pro Arg Asp Trp Phe Phe Glu Phe Trp Gly 
            100                 105                 110         


Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120     


<210>  99
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (46)..(46)
<223>  Can be L or P

<220>
<221>  VARIANT
<222>  (49)..(49)
<223>  Can be Y or F

<220>
<221>  VARIANT
<222>  (71)..(71)
<223>  Can be F or Y

<400>  99

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Gly Val Asn Asn Tyr 
            20                  25                  30          


Leu Thr Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Xaa Leu Ile 
        35                  40                  45              


Xaa Tyr Thr Ser Asn Leu Gln Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Xaa Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Tyr His Gly Phe Pro Asn 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  100
<211>  117
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (96)..(96)
<223>  Can be A or Q

<400>  100

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Val Arg Asn Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Thr Gly Asp Arg Ser Tyr Leu Pro Asp Ser Met Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Xaa 
                85                  90                  95      


Arg Tyr Phe Asp Phe Asp Ser Phe Ala Phe Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  101
<211>  108
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence

<400>  101

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Gln Asp Ile Asn Asn Phe 
            20                  25                  30          


Leu Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Tyr Thr Ser Lys Leu His Ser Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Gly His Thr Leu Pro Pro 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105             


<210>  102
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (47)..(47)
<223>  Can be W or Y

<220>
<221>  VARIANT
<222>  (48)..(48)
<223>  Can be I or M

<220>
<221>  VARIANT
<222>  (71)..(71)
<223>  Can be V or R

<220>
<221>  VARIANT
<222>  (96)..(96)
<223>  Can be A or S

<400>  102

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Xaa Xaa 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Tyr Tyr Asn Pro Ser Leu Arg 
    50                  55                  60                  


Gly Arg Val Thr Ile Ser Xaa Asp Thr Ser Lys Asn Gln Phe Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Xaa 
                85                  90                  95      


Arg Arg His Leu Gly Ser Gly Tyr Gly Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  103
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (71)..(71)
<223>  Can be F or Y

<400>  103

Asp Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Asp Val Asn Thr Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Xaa Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln His Ser Tyr Thr Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 


<210>  104
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence

<400>  104

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Val Val Gln Pro Gly Arg 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr 
            20                  25                  30          


Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Ser Ile Ser Ser Gly Gly Thr Thr Tyr Tyr Pro Asp Ser Val Lys 
    50                  55                  60                  


Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Val Gly Gly Tyr Tyr Asp Ser Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  105
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (31)..(31)
<223>  Can be N or Q

<220>
<221>  VARIANT
<222>  (57)..(57)
<223>  Can be N or Q

<400>  105

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Glu Ser Val Asp Xaa Tyr 
            20                  25                  30          


Gly Val Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro 
        35                  40                  45              


Arg Leu Leu Ile Tyr Ala Ala Ser Xaa Gln Gly Ser Gly Ile Pro Asp 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Arg Leu Glu Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Lys 
                85                  90                  95      


Glu Val Thr Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  106
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (47)..(47)
<223>  Can be W or Y

<220>
<221>  VARIANT
<222>  (48)..(48)
<223>  Can be I or M

<220>
<221>  VARIANT
<222>  (67)..(67)
<223>  Can be V or I

<220>
<221>  VARIANT
<222>  (71)..(71)
<223>  Can be V or R

<220>
<221>  VARIANT
<222>  (78)..(78)
<223>  Can be F or Y

<220>
<221>  VARIANT
<222>  (96)..(96)
<223>  Can be A or S

<400>  106

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Asp Ser Ile Thr Ser Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Xaa Xaa 
        35                  40                  45              


Gly Phe Ile Ser Tyr Ser Gly Asn Thr Tyr Tyr Asn Pro Ser Leu Arg 
    50                  55                  60                  


Ser Arg Xaa Thr Ile Ser Xaa Asp Thr Ser Lys Asn Gln Xaa Ser Leu 
65                  70                  75                  80  


Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys Xaa 
                85                  90                  95      


Arg Arg His Leu Ile Ser Gly Tyr Gly Trp Phe Ala Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  107
<211>  109
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (1)..(1)
<223>  Can be D or V

<400>  107

Xaa Ile Val Met Thr Gln Ser Pro Asp Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Glu Arg Ala Thr Ile Asn Cys Lys Ala Ser Gln Asp Val Ile Ser Ala 
            20                  25                  30          


Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro Lys Leu Leu Ile 
        35                  40                  45              


Tyr Trp Ala Ser Thr Arg His Thr Gly Val Pro Asp Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Gln Ala 
65                  70                  75                  80  


Glu Asp Val Ala Val Tyr Tyr Cys Gln Gln His Ser Tyr Thr Pro Pro 
                85                  90                  95      


Trp Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 


<210>  108
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (48)..(48)
<223>  Can be M or I

<220>
<221>  VARIANT
<222>  (68)..(68)
<223>  Can be V or A

<220>
<221>  VARIANT
<222>  (70)..(70)
<223>  Can be M or L

<220>
<221>  VARIANT
<222>  (72)..(72)
<223>  Can be T or A

<220>
<221>  VARIANT
<222>  (74)..(74)
<223>  Can be T or K

<400>  108

Gln Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Val Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Thr Met His Trp Val Arg Gln Ala Pro Gly Gln Gly Leu Glu Trp Xaa 
        35                  40                  45              


Gly Tyr Ile Asn Pro Arg Ser Val Tyr Thr Asn Tyr Asn Gln Lys Phe 
    50                  55                  60                  


Lys Asp Arg Xaa Thr Xaa Thr Xaa Asp Xaa Ser Thr Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Arg Ser Leu Arg Ser Asp Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Leu Gly Gly Tyr Tyr Asp Thr Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Leu Val Thr Val Ser Ser 
        115                 


<210>  109
<211>  112
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence

<400>  109

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Ala Ser Glu Ser Val Asp Asn Tyr 
            20                  25                  30          


Gly Ile Ser Phe Met Asn Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Ala Ala Ser Asn Gln Gly Ser Gly Val Pro Ser 
    50                  55                  60                  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser 
65                  70                  75                  80  


Ser Leu Gln Pro Glu Asp Phe Ala Thr Tyr Tyr Cys Gln Gln Ser Lys 
                85                  90                  95      


Glu Val Pro Phe Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105                 110         


<210>  110
<211>  118
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (49)..(49)
<223>  Can be I or M

<220>
<221>  VARIANT
<222>  (68)..(68)
<223>  Can be V or I

<220>
<221>  VARIANT
<222>  (72)..(72)
<223>  Can be V or R

<400>  110

Gln Val Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Glu 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Thr Val Ser Gly Tyr Ser Ile Thr Ser Asp 
            20                  25                  30          


Tyr Ala Trp Asn Trp Ile Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp 
        35                  40                  45              


Xaa Gly Tyr Ile Ser Tyr Ser Gly Ser Thr Arg Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Ser Arg Xaa Thr Ile Ser Xaa Asp Thr Ser Lys Asn Gln Phe Ser 
65                  70                  75                  80  


Leu Lys Leu Ser Ser Val Thr Ala Ala Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gln Leu Gly Leu Arg Phe Phe Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Leu Val Thr Val Ser Ser 
        115             


<210>  111
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized antibody sequence


<220>
<221>  VARIANT
<222>  (45)..(45)
<223>  Can be L or P

<220>
<221>  VARIANT
<222>  (46)..(46)
<223>  Can be L or C

<400>  111

Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Ser Ala Asn Ser Thr Val Asn Tyr Met 
            20                  25                  30          


Tyr Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Xaa Xaa Ile Tyr 
        35                  40                  45              


Leu Thr Ser Asn Leu Ala Ser Gly Ile Pro Asp Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu 
65                  70                  75                  80  


Asp Phe Ala Val Tyr Tyr Cys Gln Gln Trp Asn Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Gln Gly Thr Lys Val Glu Ile Lys Arg 
            100                 105         


