                         SEQUENCE LISTING

<110>  Koninklijke Philips Electronics N.V.
 
<120>  NOVEL TUMOR MARKERS SELECTED FROM A GROUP OF CAMP-REGULATORY 
       PATHWAY MEMBERS

<130>  PH014000 WO1

<150>  EP09169428.1
<151>  2009-09-03

<150>  EP09169423.2
<151>  2009-09-03

<160>  232   

<170>  PatentIn version 3.5

<210>  1
<211>  6960
<212>  DNA
<213>  Homo sapiens

<400>  1
atgttaacca tgagcgtgac actttccccc ctgaggtcac aggacctgga tcccatggct       60

actgatgctt cacccatggc catcaacatg acacccactg tggagcaggg tgagggagaa      120

gaggcaatga aggacatgga ctctgaccag cagtatgaaa agccaccccc actacacaca      180

ggggctgact ggaagattgt cctccactta cctgaaattg agacctggct ccggatgacc      240

tcagagaggg tccgagacct aacctattca gtccagcagg attcggacag caagcatgtg      300

gatgtacatc tagttcaact aaaggacatt tgtgaagata tttctgatca tgttgagcaa      360

atccatgccc tccttgaaac agagttctcc ctaaagctgc tgtcttactc tgtcaacgtg      420

atagtggaca tccacgcagt gcagctcctc tggcaccagc ttcgagtctc agtgctggtt      480

ctgcgggagc gcattctgca aggtctgcag gacgccaatg gcaactacac taggcagacg      540

gacattctgc aagctttctc tgaagagaca aaagagggcc ggcttgattc tctaacagaa      600

gtggatgact caggacaatt aaccatcaaa tgttctcaaa attacttgtc tctggattgt      660

ggcattactg cattcgaact gtctgactac agtccaagtg aggatttgct cagtgggcta      720

ggtgacatga cctctagcca agtcaaaacc aaaccctttg actcttggag ctacagtgag      780

atggaaaagg agtttcctga gcttatccga agtgttggtt tacttacggt agctgctgac      840

tctatctcta ccaatggcag tgaagcagtt actgaggagg tatctcaagt atctctctca      900

gtagacgaca aaggtggatg tgaggaagac aatgcttctg cagtcgaaga gcaaccaggc      960

ttaacactgg gggtgtcatc atcttcagga gaagctctga caaatgctgc tcaaccctcc     1020

tctgagactg tgcagcaaga atccagttcc tcctcccatc atgatgcaaa gaatcagcag     1080

cctgttcctt gtgaaaatgc aacccccaaa cgaaccatca gagattgctt taattataac     1140

gaggactctc ccacgcagcc tacattgcca aaaagaggac tttttcttaa agaggaaact     1200

tttaagaatg atctgaaagg caatggtgga aagaggcaaa tggttgatct aaagcctgag     1260

atgagcagaa gcaccccttc gctagtagat cctcctgaca gatccaaact ttgcctggta     1320

ttgcagtctt cttaccccaa cagcccttct gctgccagcc agtcttatga gtgtttacac     1380

aaggtgggga atgggaacct tgaaaacaca gtcaaatttc acattaaaga aatttcttcc     1440

agcctgggaa ggcttaacga ctgctataaa gagaaatctc gacttaaaaa gccacacaag     1500

acctcagaag aggtgcctcc atgccgaaca cctaaacggg ggactggttc aggcaaacaa     1560

gctaaaaata caaagagctc agcagtgcca aatggagagc tttcttatac ttccaaggcc     1620

atagaggggc cacaaacaaa ttctgcttcc acatcctcac ttgagccttg taatcagaga     1680

agttggaatg ccaaattgca attgcagtca gaaacatcca gttcaccagc ttttactcag     1740

agcagtgaat cctctgttgg ctcagacaac atcatgtctc cggtgccact tctttcaaaa     1800

cacaaaagca aaaaaggtca agcctcctct ccaagtcacg tcactaggaa tggtgaggtt     1860

gtggaggcct ggtatggctc tgatgaatac ctagcactgc cctctcacct taagcagaca     1920

gaagtattgg ctttgaagtt ggaaaaccta acaaagcttc tgcctcagaa acccagagga     1980

gaaaccatcc agaatattga tgactgggaa ctgtctgaaa tgaattcaga ttctgaaatc     2040

tatccaacct atcatgtcaa aaagaagcat acaaggctag gcagggtgtc tccaagctca     2100

tctagtgaca tagcctcttc actaggggag agcattgaat ctgggcccct gagtgacatt     2160

ctttctgatg aggagtccag tatgcctctc gctggcatga aaaagtatgc tgatgagaag     2220

tcagaaagag cttcatcctc tgagaaaaat gagagccatt ctgccactaa atcagcttta     2280

attcagaaac tgatgcaaga tattcagcac caagacaact atgaagccat atgggaaaaa     2340

atagaggggt ttgtaaacaa actggatgaa ttcattcaat ggttaaatga agccatggaa     2400

actacagaaa attggactcc ccctaaagca gagatggatg accttaaact gtatctggag     2460

acacacttga gttttaagtt gaatgtagac agtcattgtg ctctcaagga agctgtggag     2520

gaggaaggac accaacttct tgagcttatt gcatctcaca aagcaggact gaaggacatg     2580

ctgcggatga ttgcaagtca atggaaggag ctgcagaggc aaatcaaacg gcagcacagc     2640

tggattctca gggctctgga taccatcaaa gccgagatac tggctactga tgtgtctgtg     2700

gaggatgagg aagggactgg aagccccaag gctgaggttc aactatgcta cctggaagca     2760

caaagagatg ctgttgagca gatgtccctc aagctgtaca gcgagcagta taccagcagc     2820

agcaagcgaa aggaagagtt tgctgatatg tcaaaagttc attcagtggg aagcaatggg     2880

cttctggact ttgattcaga atatcaggag ctctgggatt ggctgattga catggagtcc     2940

cttgtgatgg acagccacga cctgatgatg tcagaggagc agcagcagca tctttacaag     3000

cgatacagtg tggaaatgtc catcagacac ctgaaaaaga cggagctgct tagtaaggtt     3060

gaagctttga agaaaggtgg cgttttacta ccaaatgatc tccttgaaaa agtggattca     3120

attaatgaaa aatgggaact gcttgggaaa accctaggag agaagatcca ggacacaatg     3180

gcagggcaca gtgggtcgag tccacgtgac ctgctctctc ctgaaagtgg aagcctggta     3240

aggcagctgg aggtcaggat caaagaactg aaaggatggc taagagatac agagcttttc     3300

atcttcaatt cctgtctgag acaagaaaag gaaggaacaa tgaatactga gaaacaactg     3360

caatacttta agtccctctg tcgtgaaatc aagcaacgac gtcgaggagt tgcctccatt     3420

ctgcgactat gccagcatct tttggatgac cgggagactt gcaatctgaa tgcagaccac     3480

cagcccatgc agctgatcat tgtaaatctt gaaagaaggt gggaagccat tgtcatgcaa     3540

gccgtccagt ggcaaacacg tctacaaaag aagatgggaa aggaatctga gactttgaat     3600

gtgattgatc ctggcttgat ggacctaaat gggatgagtg aggatgccct ggaatgggat     3660

gaaatggaca taagtaacaa gttaattagt ttgaatgagg aatcaaatga ccttgatcaa     3720

gaactccaac ctgttatccc ttccttgaag cttggagaga caagtaatga ggaccctggt     3780

tatgacgagg aggctgataa ccatggggga tctcagtatg cctcaaatat tactgccccc     3840

tctagtccac acatttacca ggtgtacagc ctccacaatg ttgaactcta tgaggacaac     3900

cacatgccat ttctgaaaaa caatccaaag gtcactggca tgacacagcc taatgtttta     3960

actaagagtc tcagtaaaga ctcttcattt tcatctacca aatctttgcc agatcttcta     4020

ggtggttcca atttggtaaa gccctgcgca tgtcatggag gagacatgag ccagaattca     4080

ggcagtgaga gtggaattgt cagtgaagga gacacagaaa ccactaccaa ctctgaaatg     4140

tgcttgctca atgcagtgga tgggtcccca agtaaccttg aaactgaaca tctggaccca     4200

caaatgggag atgcagttaa cgtgttaaag caaaaattta cagatgaggg ggaaagcatt     4260

aagcttccaa atagctctca gtcgtccatt tcaccagtgg gttgtgtaaa tggaaaagtt     4320

ggagatttaa acagtattac caaacatacc cctgactgtt tgggagaaga attacaagga     4380

aaacatgatg tgtttacatt ttatgattac tcatacctcc aaggctcaaa actcaaatta     4440

ccaatgataa tgaaacagtc acaaagcgaa aaagcgcatg tggaggatcc cctgcttcgt     4500

ggtttttatt ttgataaaaa atcatgcaaa tctaaacatc agactacaga gttacaacca     4560

gatgtacctc cccatgaaag gattttggca agtgcatctc atgaaatgga tcgcatttca     4620

tataaaagtg gcaatataga aaagacattc actggcatgc agaatgccaa acagctctcc     4680

cttttatctc atagttcatc tattgagtcc ctttctccag ggggtgattt atttggattg     4740

ggcatcttta aaaatggcag tgacagcctc cagcgaagca cttctttaga aagttggttg     4800

acttcctata aaagcaatga agatctcttt agctgtcaca gctctgggga tataagcgtg     4860

agcagtggct cagttggtga actaagtaaa agaacattag atctcctgaa tcgtttggag     4920

aatatccaga gcccctcaga gcaaaagata aaacgaagtg tttctgatat cactcttcaa     4980

agcagttccc aaaagatgtc ctttactggc cagatgtcat tggacatagc atcttctatc     5040

aatgaagact cagcggcatc tctaacagaa cttagcagca gtgacgagct ctctctttgc     5100

tcagaggata ttgtgttaca caagaacaag atcccggaat cgaatgcatc gttcaggaag     5160

cgtctgactc gttcagtggc tgatgaaagc gatgtcaatg tcagcatgat tgttaatgtc     5220

tcttgcacct ctgcttgcac tgatgatgaa gatgacagcg acctgctctc cagctctacc     5280

cttaccttga ctgaagaaga gctgtgcatc aaagatgagg atgacgactc cagtattgca     5340

acagatgatg aaatttatga agactgcacc ttgatgtcag ggctagacta cataaagaat     5400

gaattacaga cctggattag gccaaaattg tctttgacaa gagataagaa aaggtgcaat     5460

gtcagtgatg agatgaaggg cagtaaagat ataagtagca gtgagatgac caatccctct     5520

gatactctga atattgagac ccttctaaat ggctctgtaa aacgtgtctc tgaaaataat     5580

ggaaatggta agaattcatc tcatacccat gagttaggga caaagcgtga aaataagaaa     5640

actattttca aagttaataa agatccatat gtggctgaca tggaaaatgg caatattgaa     5700

ggtattccag aaaggcaaaa gggaaaaccg aatgtgactt caaaggtatc agaaaatctt     5760

ggttcacatg ggaaagagat ttcagagagt gagcattgta agtgtaaagc acttatggat     5820

agtttagatg attcaaatac tgctggcaag gaatttgttt cccaagatgt tagacatctt     5880

ccaaagaaat gtccaaatca ccaccatttt gaaaatcaaa gcactgcctc tactcccact     5940

gagaagtctt tctcagaact ggctttagaa accaggttta acaacagaca agactctgat     6000

gcactgaaat catctgatga tgcaccgagt atggctggaa aatctgctgg ttgttgccta     6060

gcacttgaac aaaacggaac agaggaaaat gcttctatca gcaacatttc ctgttgcaac     6120

tgtgagccag atgttttcca tcaaaaagat gccgaagatt gttcagtaca caactttgtt     6180

aaggaaatca ttgacatggc ttcgacagcc ctaaaaagta aatctcaacc tgaaaacgag     6240

gtggctgctc ctacttcatt aactcaaatc aaggagaaag tgttggagca ttctcaccgg     6300

cccatccagc tgagaaaagg ggacttttat tcgtacttat ctctctcatc tcatgacagt     6360

gattgtgggg aggtcaccaa ttacatagaa gagaaaagca gcactccatt gccactagac     6420

accactgact cgggcttaga tgacaaggaa gatattgaat gcttttttga ggcctgtgtt     6480

gagggtgact ctgatggaga ggagccttgt ttctctagtg ctcctccaaa tgaatctgca     6540

gttcccagcg aagctgcaat gccactacaa gcaacagcat gttcttctga gttcagtgat     6600

agttctcttt cagctgatga tgcagataca gtggctcttt caagtccttc ctctcaggaa     6660

agagctgagg ttggaaagga agtgaatggt ttgccccaaa cttccagtgg ctgtgcagaa     6720

aacttagagt ttactccttc aaagcttgac agtgaaaagg aaagttccgg aaaaccaggt     6780

gaatctggaa tgccagaaga acataatgct gcttcagcca aatctaaagt tcaagacctc     6840

tccttgaagg caaatcagcc aacagacaag gccgcattgc atcccagccc caaaacttta     6900

acctgtgaag aaaatcttct aaaccttcat gaaaaacgac atagaaatat gcataggtag     6960


<210>  2
<211>  2319
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Leu Thr Met Ser Val Thr Leu Ser Pro Leu Arg Ser Gln Asp Leu 
1               5                   10                  15      


Asp Pro Met Ala Thr Asp Ala Ser Pro Met Ala Ile Asn Met Thr Pro 
            20                  25                  30          


Thr Val Glu Gln Gly Glu Gly Glu Glu Ala Met Lys Asp Met Asp Ser 
        35                  40                  45              


Asp Gln Gln Tyr Glu Lys Pro Pro Pro Leu His Thr Gly Ala Asp Trp 
    50                  55                  60                  


Lys Ile Val Leu His Leu Pro Glu Ile Glu Thr Trp Leu Arg Met Thr 
65                  70                  75                  80  


Ser Glu Arg Val Arg Asp Leu Thr Tyr Ser Val Gln Gln Asp Ser Asp 
                85                  90                  95      


Ser Lys His Val Asp Val His Leu Val Gln Leu Lys Asp Ile Cys Glu 
            100                 105                 110         


Asp Ile Ser Asp His Val Glu Gln Ile His Ala Leu Leu Glu Thr Glu 
        115                 120                 125             


Phe Ser Leu Lys Leu Leu Ser Tyr Ser Val Asn Val Ile Val Asp Ile 
    130                 135                 140                 


His Ala Val Gln Leu Leu Trp His Gln Leu Arg Val Ser Val Leu Val 
145                 150                 155                 160 


Leu Arg Glu Arg Ile Leu Gln Gly Leu Gln Asp Ala Asn Gly Asn Tyr 
                165                 170                 175     


Thr Arg Gln Thr Asp Ile Leu Gln Ala Phe Ser Glu Glu Thr Lys Glu 
            180                 185                 190         


Gly Arg Leu Asp Ser Leu Thr Glu Val Asp Asp Ser Gly Gln Leu Thr 
        195                 200                 205             


Ile Lys Cys Ser Gln Asn Tyr Leu Ser Leu Asp Cys Gly Ile Thr Ala 
    210                 215                 220                 


Phe Glu Leu Ser Asp Tyr Ser Pro Ser Glu Asp Leu Leu Ser Gly Leu 
225                 230                 235                 240 


Gly Asp Met Thr Ser Ser Gln Val Lys Thr Lys Pro Phe Asp Ser Trp 
                245                 250                 255     


Ser Tyr Ser Glu Met Glu Lys Glu Phe Pro Glu Leu Ile Arg Ser Val 
            260                 265                 270         


Gly Leu Leu Thr Val Ala Ala Asp Ser Ile Ser Thr Asn Gly Ser Glu 
        275                 280                 285             


Ala Val Thr Glu Glu Val Ser Gln Val Ser Leu Ser Val Asp Asp Lys 
    290                 295                 300                 


Gly Gly Cys Glu Glu Asp Asn Ala Ser Ala Val Glu Glu Gln Pro Gly 
305                 310                 315                 320 


Leu Thr Leu Gly Val Ser Ser Ser Ser Gly Glu Ala Leu Thr Asn Ala 
                325                 330                 335     


Ala Gln Pro Ser Ser Glu Thr Val Gln Gln Glu Ser Ser Ser Ser Ser 
            340                 345                 350         


His His Asp Ala Lys Asn Gln Gln Pro Val Pro Cys Glu Asn Ala Thr 
        355                 360                 365             


Pro Lys Arg Thr Ile Arg Asp Cys Phe Asn Tyr Asn Glu Asp Ser Pro 
    370                 375                 380                 


Thr Gln Pro Thr Leu Pro Lys Arg Gly Leu Phe Leu Lys Glu Glu Thr 
385                 390                 395                 400 


Phe Lys Asn Asp Leu Lys Gly Asn Gly Gly Lys Arg Gln Met Val Asp 
                405                 410                 415     


Leu Lys Pro Glu Met Ser Arg Ser Thr Pro Ser Leu Val Asp Pro Pro 
            420                 425                 430         


Asp Arg Ser Lys Leu Cys Leu Val Leu Gln Ser Ser Tyr Pro Asn Ser 
        435                 440                 445             


Pro Ser Ala Ala Ser Gln Ser Tyr Glu Cys Leu His Lys Val Gly Asn 
    450                 455                 460                 


Gly Asn Leu Glu Asn Thr Val Lys Phe His Ile Lys Glu Ile Ser Ser 
465                 470                 475                 480 


Ser Leu Gly Arg Leu Asn Asp Cys Tyr Lys Glu Lys Ser Arg Leu Lys 
                485                 490                 495     


Lys Pro His Lys Thr Ser Glu Glu Val Pro Pro Cys Arg Thr Pro Lys 
            500                 505                 510         


Arg Gly Thr Gly Ser Gly Lys Gln Ala Lys Asn Thr Lys Ser Ser Ala 
        515                 520                 525             


Val Pro Asn Gly Glu Leu Ser Tyr Thr Ser Lys Ala Ile Glu Gly Pro 
    530                 535                 540                 


Gln Thr Asn Ser Ala Ser Thr Ser Ser Leu Glu Pro Cys Asn Gln Arg 
545                 550                 555                 560 


Ser Trp Asn Ala Lys Leu Gln Leu Gln Ser Glu Thr Ser Ser Ser Pro 
                565                 570                 575     


Ala Phe Thr Gln Ser Ser Glu Ser Ser Val Gly Ser Asp Asn Ile Met 
            580                 585                 590         


Ser Pro Val Pro Leu Leu Ser Lys His Lys Ser Lys Lys Gly Gln Ala 
        595                 600                 605             


Ser Ser Pro Ser His Val Thr Arg Asn Gly Glu Val Val Glu Ala Trp 
    610                 615                 620                 


Tyr Gly Ser Asp Glu Tyr Leu Ala Leu Pro Ser His Leu Lys Gln Thr 
625                 630                 635                 640 


Glu Val Leu Ala Leu Lys Leu Glu Asn Leu Thr Lys Leu Leu Pro Gln 
                645                 650                 655     


Lys Pro Arg Gly Glu Thr Ile Gln Asn Ile Asp Asp Trp Glu Leu Ser 
            660                 665                 670         


Glu Met Asn Ser Asp Ser Glu Ile Tyr Pro Thr Tyr His Val Lys Lys 
        675                 680                 685             


Lys His Thr Arg Leu Gly Arg Val Ser Pro Ser Ser Ser Ser Asp Ile 
    690                 695                 700                 


Ala Ser Ser Leu Gly Glu Ser Ile Glu Ser Gly Pro Leu Ser Asp Ile 
705                 710                 715                 720 


Leu Ser Asp Glu Glu Ser Ser Met Pro Leu Ala Gly Met Lys Lys Tyr 
                725                 730                 735     


Ala Asp Glu Lys Ser Glu Arg Ala Ser Ser Ser Glu Lys Asn Glu Ser 
            740                 745                 750         


His Ser Ala Thr Lys Ser Ala Leu Ile Gln Lys Leu Met Gln Asp Ile 
        755                 760                 765             


Gln His Gln Asp Asn Tyr Glu Ala Ile Trp Glu Lys Ile Glu Gly Phe 
    770                 775                 780                 


Val Asn Lys Leu Asp Glu Phe Ile Gln Trp Leu Asn Glu Ala Met Glu 
785                 790                 795                 800 


Thr Thr Glu Asn Trp Thr Pro Pro Lys Ala Glu Met Asp Asp Leu Lys 
                805                 810                 815     


Leu Tyr Leu Glu Thr His Leu Ser Phe Lys Leu Asn Val Asp Ser His 
            820                 825                 830         


Cys Ala Leu Lys Glu Ala Val Glu Glu Glu Gly His Gln Leu Leu Glu 
        835                 840                 845             


Leu Ile Ala Ser His Lys Ala Gly Leu Lys Asp Met Leu Arg Met Ile 
    850                 855                 860                 


Ala Ser Gln Trp Lys Glu Leu Gln Arg Gln Ile Lys Arg Gln His Ser 
865                 870                 875                 880 


Trp Ile Leu Arg Ala Leu Asp Thr Ile Lys Ala Glu Ile Leu Ala Thr 
                885                 890                 895     


Asp Val Ser Val Glu Asp Glu Glu Gly Thr Gly Ser Pro Lys Ala Glu 
            900                 905                 910         


Val Gln Leu Cys Tyr Leu Glu Ala Gln Arg Asp Ala Val Glu Gln Met 
        915                 920                 925             


Ser Leu Lys Leu Tyr Ser Glu Gln Tyr Thr Ser Ser Ser Lys Arg Lys 
    930                 935                 940                 


Glu Glu Phe Ala Asp Met Ser Lys Val His Ser Val Gly Ser Asn Gly 
945                 950                 955                 960 


Leu Leu Asp Phe Asp Ser Glu Tyr Gln Glu Leu Trp Asp Trp Leu Ile 
                965                 970                 975     


Asp Met Glu Ser Leu Val Met Asp Ser His Asp Leu Met Met Ser Glu 
            980                 985                 990         


Glu Gln Gln Gln His Leu Tyr Lys  Arg Tyr Ser Val Glu  Met Ser Ile 
        995                 1000                 1005             


Arg His  Leu Lys Lys Thr Glu  Leu Leu Ser Lys Val  Glu Ala Leu 
    1010                 1015                 1020             


Lys Lys  Gly Gly Val Leu Leu  Pro Asn Asp Leu Leu  Glu Lys Val 
    1025                 1030                 1035             


Asp Ser  Ile Asn Glu Lys Trp  Glu Leu Leu Gly Lys  Thr Leu Gly 
    1040                 1045                 1050             


Glu Lys  Ile Gln Asp Thr Met  Ala Gly His Ser Gly  Ser Ser Pro 
    1055                 1060                 1065             


Arg Asp  Leu Leu Ser Pro Glu  Ser Gly Ser Leu Val  Arg Gln Leu 
    1070                 1075                 1080             


Glu Val  Arg Ile Lys Glu Leu  Lys Gly Trp Leu Arg  Asp Thr Glu 
    1085                 1090                 1095             


Leu Phe  Ile Phe Asn Ser Cys  Leu Arg Gln Glu Lys  Glu Gly Thr 
    1100                 1105                 1110             


Met Asn  Thr Glu Lys Gln Leu  Gln Tyr Phe Lys Ser  Leu Cys Arg 
    1115                 1120                 1125             


Glu Ile  Lys Gln Arg Arg Arg  Gly Val Ala Ser Ile  Leu Arg Leu 
    1130                 1135                 1140             


Cys Gln  His Leu Leu Asp Asp  Arg Glu Thr Cys Asn  Leu Asn Ala 
    1145                 1150                 1155             


Asp His  Gln Pro Met Gln Leu  Ile Ile Val Asn Leu  Glu Arg Arg 
    1160                 1165                 1170             


Trp Glu  Ala Ile Val Met Gln  Ala Val Gln Trp Gln  Thr Arg Leu 
    1175                 1180                 1185             


Gln Lys  Lys Met Gly Lys Glu  Ser Glu Thr Leu Asn  Val Ile Asp 
    1190                 1195                 1200             


Pro Gly  Leu Met Asp Leu Asn  Gly Met Ser Glu Asp  Ala Leu Glu 
    1205                 1210                 1215             


Trp Asp  Glu Met Asp Ile Ser  Asn Lys Leu Ile Ser  Leu Asn Glu 
    1220                 1225                 1230             


Glu Ser  Asn Asp Leu Asp Gln  Glu Leu Gln Pro Val  Ile Pro Ser 
    1235                 1240                 1245             


Leu Lys  Leu Gly Glu Thr Ser  Asn Glu Asp Pro Gly  Tyr Asp Glu 
    1250                 1255                 1260             


Glu Ala  Asp Asn His Gly Gly  Ser Gln Tyr Ala Ser  Asn Ile Thr 
    1265                 1270                 1275             


Ala Pro  Ser Ser Pro His Ile  Tyr Gln Val Tyr Ser  Leu His Asn 
    1280                 1285                 1290             


Val Glu  Leu Tyr Glu Asp Asn  His Met Pro Phe Leu  Lys Asn Asn 
    1295                 1300                 1305             


Pro Lys  Val Thr Gly Met Thr  Gln Pro Asn Val Leu  Thr Lys Ser 
    1310                 1315                 1320             


Leu Ser  Lys Asp Ser Ser Phe  Ser Ser Thr Lys Ser  Leu Pro Asp 
    1325                 1330                 1335             


Leu Leu  Gly Gly Ser Asn Leu  Val Lys Pro Cys Ala  Cys His Gly 
    1340                 1345                 1350             


Gly Asp  Met Ser Gln Asn Ser  Gly Ser Glu Ser Gly  Ile Val Ser 
    1355                 1360                 1365             


Glu Gly  Asp Thr Glu Thr Thr  Thr Asn Ser Glu Met  Cys Leu Leu 
    1370                 1375                 1380             


Asn Ala  Val Asp Gly Ser Pro  Ser Asn Leu Glu Thr  Glu His Leu 
    1385                 1390                 1395             


Asp Pro  Gln Met Gly Asp Ala  Val Asn Val Leu Lys  Gln Lys Phe 
    1400                 1405                 1410             


Thr Asp  Glu Gly Glu Ser Ile  Lys Leu Pro Asn Ser  Ser Gln Ser 
    1415                 1420                 1425             


Ser Ile  Ser Pro Val Gly Cys  Val Asn Gly Lys Val  Gly Asp Leu 
    1430                 1435                 1440             


Asn Ser  Ile Thr Lys His Thr  Pro Asp Cys Leu Gly  Glu Glu Leu 
    1445                 1450                 1455             


Gln Gly  Lys His Asp Val Phe  Thr Phe Tyr Asp Tyr  Ser Tyr Leu 
    1460                 1465                 1470             


Gln Gly  Ser Lys Leu Lys Leu  Pro Met Ile Met Lys  Gln Ser Gln 
    1475                 1480                 1485             


Ser Glu  Lys Ala His Val Glu  Asp Pro Leu Leu Arg  Gly Phe Tyr 
    1490                 1495                 1500             


Phe Asp  Lys Lys Ser Cys Lys  Ser Lys His Gln Thr  Thr Glu Leu 
    1505                 1510                 1515             


Gln Pro  Asp Val Pro Pro His  Glu Arg Ile Leu Ala  Ser Ala Ser 
    1520                 1525                 1530             


His Glu  Met Asp Arg Ile Ser  Tyr Lys Ser Gly Asn  Ile Glu Lys 
    1535                 1540                 1545             


Thr Phe  Thr Gly Met Gln Asn  Ala Lys Gln Leu Ser  Leu Leu Ser 
    1550                 1555                 1560             


His Ser  Ser Ser Ile Glu Ser  Leu Ser Pro Gly Gly  Asp Leu Phe 
    1565                 1570                 1575             


Gly Leu  Gly Ile Phe Lys Asn  Gly Ser Asp Ser Leu  Gln Arg Ser 
    1580                 1585                 1590             


Thr Ser  Leu Glu Ser Trp Leu  Thr Ser Tyr Lys Ser  Asn Glu Asp 
    1595                 1600                 1605             


Leu Phe  Ser Cys His Ser Ser  Gly Asp Ile Ser Val  Ser Ser Gly 
    1610                 1615                 1620             


Ser Val  Gly Glu Leu Ser Lys  Arg Thr Leu Asp Leu  Leu Asn Arg 
    1625                 1630                 1635             


Leu Glu  Asn Ile Gln Ser Pro  Ser Glu Gln Lys Ile  Lys Arg Ser 
    1640                 1645                 1650             


Val Ser  Asp Ile Thr Leu Gln  Ser Ser Ser Gln Lys  Met Ser Phe 
    1655                 1660                 1665             


Thr Gly  Gln Met Ser Leu Asp  Ile Ala Ser Ser Ile  Asn Glu Asp 
    1670                 1675                 1680             


Ser Ala  Ala Ser Leu Thr Glu  Leu Ser Ser Ser Asp  Glu Leu Ser 
    1685                 1690                 1695             


Leu Cys  Ser Glu Asp Ile Val  Leu His Lys Asn Lys  Ile Pro Glu 
    1700                 1705                 1710             


Ser Asn  Ala Ser Phe Arg Lys  Arg Leu Thr Arg Ser  Val Ala Asp 
    1715                 1720                 1725             


Glu Ser  Asp Val Asn Val Ser  Met Ile Val Asn Val  Ser Cys Thr 
    1730                 1735                 1740             


Ser Ala  Cys Thr Asp Asp Glu  Asp Asp Ser Asp Leu  Leu Ser Ser 
    1745                 1750                 1755             


Ser Thr  Leu Thr Leu Thr Glu  Glu Glu Leu Cys Ile  Lys Asp Glu 
    1760                 1765                 1770             


Asp Asp  Asp Ser Ser Ile Ala  Thr Asp Asp Glu Ile  Tyr Glu Asp 
    1775                 1780                 1785             


Cys Thr  Leu Met Ser Gly Leu  Asp Tyr Ile Lys Asn  Glu Leu Gln 
    1790                 1795                 1800             


Thr Trp  Ile Arg Pro Lys Leu  Ser Leu Thr Arg Asp  Lys Lys Arg 
    1805                 1810                 1815             


Cys Asn  Val Ser Asp Glu Met  Lys Gly Ser Lys Asp  Ile Ser Ser 
    1820                 1825                 1830             


Ser Glu  Met Thr Asn Pro Ser  Asp Thr Leu Asn Ile  Glu Thr Leu 
    1835                 1840                 1845             


Leu Asn  Gly Ser Val Lys Arg  Val Ser Glu Asn Asn  Gly Asn Gly 
    1850                 1855                 1860             


Lys Asn  Ser Ser His Thr His  Glu Leu Gly Thr Lys  Arg Glu Asn 
    1865                 1870                 1875             


Lys Lys  Thr Ile Phe Lys Val  Asn Lys Asp Pro Tyr  Val Ala Asp 
    1880                 1885                 1890             


Met Glu  Asn Gly Asn Ile Glu  Gly Ile Pro Glu Arg  Gln Lys Gly 
    1895                 1900                 1905             


Lys Pro  Asn Val Thr Ser Lys  Val Ser Glu Asn Leu  Gly Ser His 
    1910                 1915                 1920             


Gly Lys  Glu Ile Ser Glu Ser  Glu His Cys Lys Cys  Lys Ala Leu 
    1925                 1930                 1935             


Met Asp  Ser Leu Asp Asp Ser  Asn Thr Ala Gly Lys  Glu Phe Val 
    1940                 1945                 1950             


Ser Gln  Asp Val Arg His Leu  Pro Lys Lys Cys Pro  Asn His His 
    1955                 1960                 1965             


His Phe  Glu Asn Gln Ser Thr  Ala Ser Thr Pro Thr  Glu Lys Ser 
    1970                 1975                 1980             


Phe Ser  Glu Leu Ala Leu Glu  Thr Arg Phe Asn Asn  Arg Gln Asp 
    1985                 1990                 1995             


Ser Asp  Ala Leu Lys Ser Ser  Asp Asp Ala Pro Ser  Met Ala Gly 
    2000                 2005                 2010             


Lys Ser  Ala Gly Cys Cys Leu  Ala Leu Glu Gln Asn  Gly Thr Glu 
    2015                 2020                 2025             


Glu Asn  Ala Ser Ile Ser Asn  Ile Ser Cys Cys Asn  Cys Glu Pro 
    2030                 2035                 2040             


Asp Val  Phe His Gln Lys Asp  Ala Glu Asp Cys Ser  Val His Asn 
    2045                 2050                 2055             


Phe Val  Lys Glu Ile Ile Asp  Met Ala Ser Thr Ala  Leu Lys Ser 
    2060                 2065                 2070             


Lys Ser  Gln Pro Glu Asn Glu  Val Ala Ala Pro Thr  Ser Leu Thr 
    2075                 2080                 2085             


Gln Ile  Lys Glu Lys Val Leu  Glu His Ser His Arg  Pro Ile Gln 
    2090                 2095                 2100             


Leu Arg  Lys Gly Asp Phe Tyr  Ser Tyr Leu Ser Leu  Ser Ser His 
    2105                 2110                 2115             


Asp Ser  Asp Cys Gly Glu Val  Thr Asn Tyr Ile Glu  Glu Lys Ser 
    2120                 2125                 2130             


Ser Thr  Pro Leu Pro Leu Asp  Thr Thr Asp Ser Gly  Leu Asp Asp 
    2135                 2140                 2145             


Lys Glu  Asp Ile Glu Cys Phe  Phe Glu Ala Cys Val  Glu Gly Asp 
    2150                 2155                 2160             


Ser Asp  Gly Glu Glu Pro Cys  Phe Ser Ser Ala Pro  Pro Asn Glu 
    2165                 2170                 2175             


Ser Ala  Val Pro Ser Glu Ala  Ala Met Pro Leu Gln  Ala Thr Ala 
    2180                 2185                 2190             


Cys Ser  Ser Glu Phe Ser Asp  Ser Ser Leu Ser Ala  Asp Asp Ala 
    2195                 2200                 2205             


Asp Thr  Val Ala Leu Ser Ser  Pro Ser Ser Gln Glu  Arg Ala Glu 
    2210                 2215                 2220             


Val Gly  Lys Glu Val Asn Gly  Leu Pro Gln Thr Ser  Ser Gly Cys 
    2225                 2230                 2235             


Ala Glu  Asn Leu Glu Phe Thr  Pro Ser Lys Leu Asp  Ser Glu Lys 
    2240                 2245                 2250             


Glu Ser  Ser Gly Lys Pro Gly  Glu Ser Gly Met Pro  Glu Glu His 
    2255                 2260                 2265             


Asn Ala  Ala Ser Ala Lys Ser  Lys Val Gln Asp Leu  Ser Leu Lys 
    2270                 2275                 2280             


Ala Asn  Gln Pro Thr Asp Lys  Ala Ala Leu His Pro  Ser Pro Lys 
    2285                 2290                 2295             


Thr Leu  Thr Cys Glu Glu Asn  Leu Leu Asn Leu His  Glu Lys Arg 
    2300                 2305                 2310             


His Arg  Asn Met His Arg 
    2315                 


<210>  3
<211>  2430
<212>  DNA
<213>  Homo sapiens

<400>  3
atgtttaaat cgctgacaaa agtcaacaag gtgaagccta taggagagaa caatgagaat       60

gaacaaagtt ctcgtcggaa tgaagaaggc tctcacccaa gtaatcagtc tcagcaaacc      120

acagcacagg aagaaaacaa aggtgaagag aaatctctca aaaccaagtc aactccagtc      180

acgtctgaag agccacacac caacatacaa gacaaactct ccaagaaaaa ttcctctgga      240

gatctgacca caaaccctga ccctcaaaat gcagcagaac caactggaac agtgccagag      300

cagaaggaaa tggaccccgg gaaagaaggt ccaaacagcc cacaaaacaa accgcctgca      360

gctcctgtta taaatgagta tgccgatgcc cagctacaca acctggtgaa aagaatgcgt      420

caaagaacag ccctctacaa gaaaaagttg gtagagggag atctctcctc acccgaagcc      480

agcccacaaa ctgcaaagcc cacggctgta ccaccagtaa aagaaagcga tgataagcca      540

acagaacatt actacaggct gttgtggttc aaagtcaaaa agatgccttt aacagagtac      600

ttaaagcgaa ttaaacttcc aaacagcata gattcataca cagatcgact ctatctcctg      660

tggctcttgc ttgtcactct tgcctataac tggaactgct gttttatacc actgcgcctc      720

gtcttcccat atcaaaccgc agacaacata cactactggc ttattgcgga catcatatgt      780

gatatcatct acctttatga tatgctattt atccagccca gactccagtt tgtaagagga      840

ggagacataa tagtggattc aaatgagcta aggaaacact acaggacttc tacaaaattt      900

cagttggatg tcgcatcaat aataccattt gatatttgct acctcttctt tgggtttaat      960

ccaatgttta gagcaaatag gatgttaaag tacacttcat tttttgaatt taatcatcac     1020

ctagagtcta taatggacaa agcatatatc tacagagtta ttcgaacaac tggatacttg     1080

ctgtttattc tgcacattaa tgcctgtgtt tattactggg cttcaaacta tgaaggaatt     1140

ggcactacta gatgggtgta tgatggggaa ggaaacgagt atctgagatg ttattattgg     1200

gcagttcgaa ctttaattac cattggtggc cttccagaac cacaaacttt atttgaaatt     1260

gtttttcaac tcttgaattt tttttctgga gtttttgtgt tctccagttt aattggtcag     1320

atgagagatg tgattggagc agctacagcc aatcagaact acttccgcgc ctgcatggat     1380

gacaccattg cctacatgaa caattactcc attcctaaac ttgtgcaaaa gcgagttcgg     1440

acttggtatg aatatacatg ggactctcaa agaatgctag atgagtctga tttgcttaag     1500

accctaccaa ctacggtcca gttagccctc gccattgatg tgaacttcag catcatcagc     1560

aaagtcgact tgttcaaggg ttgtgataca cagatgattt atgacatgtt gctaagattg     1620

aaatccgttc tctatttgcc tggtgacttt gtctgcaaaa agggagaaat tggcaaggaa     1680

atgtatatca tcaagcatgg agaagtccaa gttcttggag gccctgatgg tactaaagtt     1740

ctggttactc tgaaagctgg gtcggtgttt ggagaaatca gccttctagc agcaggagga     1800

ggaaaccgtc gaactgccaa tgtggtggcc cacgggtttg ccaatctttt aactctagac     1860

aaaaagaccc tccaagaaat tctagtgcat tatccagatt ctgaaaggat cctcatgaag     1920

aaagccagag tgcttttaaa gcagaaggct aagaccgcag aagcaacccc tccaagaaaa     1980

gatcttgccc tcctcttccc accgaaagaa gagacaccca aactgtttaa aactctccta     2040

ggaggcacag gaaaagcaag tcttgcaaga ctactcaaat tgaagcgaga gcaagcagct     2100

cagaagaaag aaaattctga aggaggagag gaagaaggaa aagaaaatga agataaacaa     2160

aaagaaaatg aagataaaca aaaagaaaat gaagataaag gaaaagaaaa tgaagataaa     2220

gataaaggaa gagagccaga agagaagcca ctggacagac ctgaatgtac agcaagtcct     2280

attgcagtgg aggaagaacc ccactcagtt agaaggacag ttttacccag agggacttct     2340

cgtcaatcac tcattatcag catggctcct tctgctgagg gcggagaaga ggttcttact     2400

attgaagtca aagaaaaggc taagcaataa                                      2430


<210>  4
<211>  809
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Phe Lys Ser Leu Thr Lys Val Asn Lys Val Lys Pro Ile Gly Glu 
1               5                   10                  15      


Asn Asn Glu Asn Glu Gln Ser Ser Arg Arg Asn Glu Glu Gly Ser His 
            20                  25                  30          


Pro Ser Asn Gln Ser Gln Gln Thr Thr Ala Gln Glu Glu Asn Lys Gly 
        35                  40                  45              


Glu Glu Lys Ser Leu Lys Thr Lys Ser Thr Pro Val Thr Ser Glu Glu 
    50                  55                  60                  


Pro His Thr Asn Ile Gln Asp Lys Leu Ser Lys Lys Asn Ser Ser Gly 
65                  70                  75                  80  


Asp Leu Thr Thr Asn Pro Asp Pro Gln Asn Ala Ala Glu Pro Thr Gly 
                85                  90                  95      


Thr Val Pro Glu Gln Lys Glu Met Asp Pro Gly Lys Glu Gly Pro Asn 
            100                 105                 110         


Ser Pro Gln Asn Lys Pro Pro Ala Ala Pro Val Ile Asn Glu Tyr Ala 
        115                 120                 125             


Asp Ala Gln Leu His Asn Leu Val Lys Arg Met Arg Gln Arg Thr Ala 
    130                 135                 140                 


Leu Tyr Lys Lys Lys Leu Val Glu Gly Asp Leu Ser Ser Pro Glu Ala 
145                 150                 155                 160 


Ser Pro Gln Thr Ala Lys Pro Thr Ala Val Pro Pro Val Lys Glu Ser 
                165                 170                 175     


Asp Asp Lys Pro Thr Glu His Tyr Tyr Arg Leu Leu Trp Phe Lys Val 
            180                 185                 190         


Lys Lys Met Pro Leu Thr Glu Tyr Leu Lys Arg Ile Lys Leu Pro Asn 
        195                 200                 205             


Ser Ile Asp Ser Tyr Thr Asp Arg Leu Tyr Leu Leu Trp Leu Leu Leu 
    210                 215                 220                 


Val Thr Leu Ala Tyr Asn Trp Asn Cys Cys Phe Ile Pro Leu Arg Leu 
225                 230                 235                 240 


Val Phe Pro Tyr Gln Thr Ala Asp Asn Ile His Tyr Trp Leu Ile Ala 
                245                 250                 255     


Asp Ile Ile Cys Asp Ile Ile Tyr Leu Tyr Asp Met Leu Phe Ile Gln 
            260                 265                 270         


Pro Arg Leu Gln Phe Val Arg Gly Gly Asp Ile Ile Val Asp Ser Asn 
        275                 280                 285             


Glu Leu Arg Lys His Tyr Arg Thr Ser Thr Lys Phe Gln Leu Asp Val 
    290                 295                 300                 


Ala Ser Ile Ile Pro Phe Asp Ile Cys Tyr Leu Phe Phe Gly Phe Asn 
305                 310                 315                 320 


Pro Met Phe Arg Ala Asn Arg Met Leu Lys Tyr Thr Ser Phe Phe Glu 
                325                 330                 335     


Phe Asn His His Leu Glu Ser Ile Met Asp Lys Ala Tyr Ile Tyr Arg 
            340                 345                 350         


Val Ile Arg Thr Thr Gly Tyr Leu Leu Phe Ile Leu His Ile Asn Ala 
        355                 360                 365             


Cys Val Tyr Tyr Trp Ala Ser Asn Tyr Glu Gly Ile Gly Thr Thr Arg 
    370                 375                 380                 


Trp Val Tyr Asp Gly Glu Gly Asn Glu Tyr Leu Arg Cys Tyr Tyr Trp 
385                 390                 395                 400 


Ala Val Arg Thr Leu Ile Thr Ile Gly Gly Leu Pro Glu Pro Gln Thr 
                405                 410                 415     


Leu Phe Glu Ile Val Phe Gln Leu Leu Asn Phe Phe Ser Gly Val Phe 
            420                 425                 430         


Val Phe Ser Ser Leu Ile Gly Gln Met Arg Asp Val Ile Gly Ala Ala 
        435                 440                 445             


Thr Ala Asn Gln Asn Tyr Phe Arg Ala Cys Met Asp Asp Thr Ile Ala 
    450                 455                 460                 


Tyr Met Asn Asn Tyr Ser Ile Pro Lys Leu Val Gln Lys Arg Val Arg 
465                 470                 475                 480 


Thr Trp Tyr Glu Tyr Thr Trp Asp Ser Gln Arg Met Leu Asp Glu Ser 
                485                 490                 495     


Asp Leu Leu Lys Thr Leu Pro Thr Thr Val Gln Leu Ala Leu Ala Ile 
            500                 505                 510         


Asp Val Asn Phe Ser Ile Ile Ser Lys Val Asp Leu Phe Lys Gly Cys 
        515                 520                 525             


Asp Thr Gln Met Ile Tyr Asp Met Leu Leu Arg Leu Lys Ser Val Leu 
    530                 535                 540                 


Tyr Leu Pro Gly Asp Phe Val Cys Lys Lys Gly Glu Ile Gly Lys Glu 
545                 550                 555                 560 


Met Tyr Ile Ile Lys His Gly Glu Val Gln Val Leu Gly Gly Pro Asp 
                565                 570                 575     


Gly Thr Lys Val Leu Val Thr Leu Lys Ala Gly Ser Val Phe Gly Glu 
            580                 585                 590         


Ile Ser Leu Leu Ala Ala Gly Gly Gly Asn Arg Arg Thr Ala Asn Val 
        595                 600                 605             


Val Ala His Gly Phe Ala Asn Leu Leu Thr Leu Asp Lys Lys Thr Leu 
    610                 615                 620                 


Gln Glu Ile Leu Val His Tyr Pro Asp Ser Glu Arg Ile Leu Met Lys 
625                 630                 635                 640 


Lys Ala Arg Val Leu Leu Lys Gln Lys Ala Lys Thr Ala Glu Ala Thr 
                645                 650                 655     


Pro Pro Arg Lys Asp Leu Ala Leu Leu Phe Pro Pro Lys Glu Glu Thr 
            660                 665                 670         


Pro Lys Leu Phe Lys Thr Leu Leu Gly Gly Thr Gly Lys Ala Ser Leu 
        675                 680                 685             


Ala Arg Leu Leu Lys Leu Lys Arg Glu Gln Ala Ala Gln Lys Lys Glu 
    690                 695                 700                 


Asn Ser Glu Gly Gly Glu Glu Glu Gly Lys Glu Asn Glu Asp Lys Gln 
705                 710                 715                 720 


Lys Glu Asn Glu Asp Lys Gln Lys Glu Asn Glu Asp Lys Gly Lys Glu 
                725                 730                 735     


Asn Glu Asp Lys Asp Lys Gly Arg Glu Pro Glu Glu Lys Pro Leu Asp 
            740                 745                 750         


Arg Pro Glu Cys Thr Ala Ser Pro Ile Ala Val Glu Glu Glu Pro His 
        755                 760                 765             


Ser Val Arg Arg Thr Val Leu Pro Arg Gly Thr Ser Arg Gln Ser Leu 
    770                 775                 780                 


Ile Ile Ser Met Ala Pro Ser Ala Glu Gly Gly Glu Glu Val Leu Thr 
785                 790                 795                 800 


Ile Glu Val Lys Glu Lys Ala Lys Gln 
                805                 


<210>  5
<211>  2289
<212>  DNA
<213>  Homo sapiens

<400>  5
atgggaaatg gttcagtgaa acctaaacat tctaagcacc cagatggaca ctctgggaac       60

ctcaccactg atgctctgcg gaacaaggtg acagagctgg agagagagtt gaggaggaag      120

gatgctgaga tccaggagcg ggagtaccat ttgaaggagc tgcgggagca gctgtcgaag      180

cagactgtgg ccattgctga actcacagag gagctccaga acaagtgcat ccagctgaac      240

aagctgcagg atgtggtgca tatgcaggga ggaagcccgc ttcaggcctc tccagataaa      300

gtgcctcttg aggtccaccg gaagacctct ggattggtct ctctccatag caggagggga      360

gcaaaggctg gcgtgtctgc tgagccaaca acccggacct atgacctgaa caaaccccct      420

gaattttcct ttgagaaagc aagagtcaga aaagactcca gtgagaagaa gctcattaca      480

gatgccctta ataaaaatca gtttctgaaa agactggatc ctcagcagat caaagacatg      540

gtggaatgca tgtatgggag aaactatcag caagggagtt acattattaa gcaaggagaa      600

ccaggaaacc atatctttgt gctggcagag ggtcgactag aggtgttcca aggggagaaa      660

ttgctgtcct ccatccctat gtggaccaca tttggggagc ttgccatttt atacaattgt      720

acaaggactg cctctgtgaa agctattacc aatgttaaaa catgggcact agatcgagag      780

gtattccaga atataatgag gaggacagcc caagctagag atgaacaata cagaaacttc      840

ctcagaagtg tatccttgct gaagaattta cctgaagata aattaaccaa gatcattgac      900

tgcttggaag tggaatacta tgacaaagga gattacatca ttagagaggg cgaggaagga      960

agtacctttt tcattttggc aaaaggaaag gtaaaagtaa cacagagcac agaaggccat     1020

gatcaaccac agctgataaa aacactgcag aaaggagaat actttggaga aaaagctctt     1080

atcagtgatg atgtcaggtc agctaacatt attgctgaag aaaatgatgt tgcatgcctg     1140

gttatagatc gagaaacatt caaccaaact gtcggtacat ttgaagagct gcaaaaatac     1200

cttgaaggat atgtggcaaa cctgaaccgt gatgatgaaa aaagacatgc gaagcggtcc     1260

atgtctaact ggaagctgtc caaagcactc tctctggaaa tgattcagct gaaggagaag     1320

gtggccagat tttcctcatc atccccattc cagaaccttg agattattgc aacactgggc     1380

gttggtgggt tcggaagagt tgagcttgtt aaagtaaaaa atgagaatgt tgcttttgct     1440

atgaagtgta taaggaagaa gcacatagtt gacaccaagc agcaggagca tgtctactca     1500

gagaagagga tcctagagga gctgtgctct ccattcattg tgaaattata tcgtactttc     1560

aaggacaata agtatgtata catgcttctg gaggcctgct taggtgggga gctctggagt     1620

atattaaggg acagaggcag ctttgatgaa cccacctcca aattctgcgt tgcttgtgtg     1680

acagaagcat ttgattacct gcatcgacta ggtattatct acagagactt gaaaccagaa     1740

aacttaattc tagatgctga gggttacctt aaattggttg actttggatt tgcgaagaaa     1800

atagggtctg gacagaaaac atggacattc tgtgggactc cagaatatgt agctcctgaa     1860

gtcattctca acaagggaca tgacttcagt gtggatttct ggtcactggg aattctagtg     1920

tatgagctcc taacgggcaa cccacccttt tctggggttg accaaatgat gacctacaat     1980

ttgattctca aaggaattga aaaaatggat tttcccagga agataacacg acgacctgag     2040

gatttgattc ggaggctttg caggcaaaat ccaacagaaa ggctgggaaa tctgaagaat     2100

ggaataaatg acattaagaa acacaggtgg ttaaatggtt ttaattggga gggactgaaa     2160

gcacggagcc ttccatcacc tttgcaaaga gagctcaagg gacccataga tcacagctac     2220

tttgacaaat atcctcctga aaagggaatg cctccagatg agctatcagg ctgggataaa     2280

gacttctga                                                             2289


<210>  6
<211>  762
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Gly Asn Gly Ser Val Lys Pro Lys His Ser Lys His Pro Asp Gly 
1               5                   10                  15      


His Ser Gly Asn Leu Thr Thr Asp Ala Leu Arg Asn Lys Val Thr Glu 
            20                  25                  30          


Leu Glu Arg Glu Leu Arg Arg Lys Asp Ala Glu Ile Gln Glu Arg Glu 
        35                  40                  45              


Tyr His Leu Lys Glu Leu Arg Glu Gln Leu Ser Lys Gln Thr Val Ala 
    50                  55                  60                  


Ile Ala Glu Leu Thr Glu Glu Leu Gln Asn Lys Cys Ile Gln Leu Asn 
65                  70                  75                  80  


Lys Leu Gln Asp Val Val His Met Gln Gly Gly Ser Pro Leu Gln Ala 
                85                  90                  95      


Ser Pro Asp Lys Val Pro Leu Glu Val His Arg Lys Thr Ser Gly Leu 
            100                 105                 110         


Val Ser Leu His Ser Arg Arg Gly Ala Lys Ala Gly Val Ser Ala Glu 
        115                 120                 125             


Pro Thr Thr Arg Thr Tyr Asp Leu Asn Lys Pro Pro Glu Phe Ser Phe 
    130                 135                 140                 


Glu Lys Ala Arg Val Arg Lys Asp Ser Ser Glu Lys Lys Leu Ile Thr 
145                 150                 155                 160 


Asp Ala Leu Asn Lys Asn Gln Phe Leu Lys Arg Leu Asp Pro Gln Gln 
                165                 170                 175     


Ile Lys Asp Met Val Glu Cys Met Tyr Gly Arg Asn Tyr Gln Gln Gly 
            180                 185                 190         


Ser Tyr Ile Ile Lys Gln Gly Glu Pro Gly Asn His Ile Phe Val Leu 
        195                 200                 205             


Ala Glu Gly Arg Leu Glu Val Phe Gln Gly Glu Lys Leu Leu Ser Ser 
    210                 215                 220                 


Ile Pro Met Trp Thr Thr Phe Gly Glu Leu Ala Ile Leu Tyr Asn Cys 
225                 230                 235                 240 


Thr Arg Thr Ala Ser Val Lys Ala Ile Thr Asn Val Lys Thr Trp Ala 
                245                 250                 255     


Leu Asp Arg Glu Val Phe Gln Asn Ile Met Arg Arg Thr Ala Gln Ala 
            260                 265                 270         


Arg Asp Glu Gln Tyr Arg Asn Phe Leu Arg Ser Val Ser Leu Leu Lys 
        275                 280                 285             


Asn Leu Pro Glu Asp Lys Leu Thr Lys Ile Ile Asp Cys Leu Glu Val 
    290                 295                 300                 


Glu Tyr Tyr Asp Lys Gly Asp Tyr Ile Ile Arg Glu Gly Glu Glu Gly 
305                 310                 315                 320 


Ser Thr Phe Phe Ile Leu Ala Lys Gly Lys Val Lys Val Thr Gln Ser 
                325                 330                 335     


Thr Glu Gly His Asp Gln Pro Gln Leu Ile Lys Thr Leu Gln Lys Gly 
            340                 345                 350         


Glu Tyr Phe Gly Glu Lys Ala Leu Ile Ser Asp Asp Val Arg Ser Ala 
        355                 360                 365             


Asn Ile Ile Ala Glu Glu Asn Asp Val Ala Cys Leu Val Ile Asp Arg 
    370                 375                 380                 


Glu Thr Phe Asn Gln Thr Val Gly Thr Phe Glu Glu Leu Gln Lys Tyr 
385                 390                 395                 400 


Leu Glu Gly Tyr Val Ala Asn Leu Asn Arg Asp Asp Glu Lys Arg His 
                405                 410                 415     


Ala Lys Arg Ser Met Ser Asn Trp Lys Leu Ser Lys Ala Leu Ser Leu 
            420                 425                 430         


Glu Met Ile Gln Leu Lys Glu Lys Val Ala Arg Phe Ser Ser Ser Ser 
        435                 440                 445             


Pro Phe Gln Asn Leu Glu Ile Ile Ala Thr Leu Gly Val Gly Gly Phe 
    450                 455                 460                 


Gly Arg Val Glu Leu Val Lys Val Lys Asn Glu Asn Val Ala Phe Ala 
465                 470                 475                 480 


Met Lys Cys Ile Arg Lys Lys His Ile Val Asp Thr Lys Gln Gln Glu 
                485                 490                 495     


His Val Tyr Ser Glu Lys Arg Ile Leu Glu Glu Leu Cys Ser Pro Phe 
            500                 505                 510         


Ile Val Lys Leu Tyr Arg Thr Phe Lys Asp Asn Lys Tyr Val Tyr Met 
        515                 520                 525             


Leu Leu Glu Ala Cys Leu Gly Gly Glu Leu Trp Ser Ile Leu Arg Asp 
    530                 535                 540                 


Arg Gly Ser Phe Asp Glu Pro Thr Ser Lys Phe Cys Val Ala Cys Val 
545                 550                 555                 560 


Thr Glu Ala Phe Asp Tyr Leu His Arg Leu Gly Ile Ile Tyr Arg Asp 
                565                 570                 575     


Leu Lys Pro Glu Asn Leu Ile Leu Asp Ala Glu Gly Tyr Leu Lys Leu 
            580                 585                 590         


Val Asp Phe Gly Phe Ala Lys Lys Ile Gly Ser Gly Gln Lys Thr Trp 
        595                 600                 605             


Thr Phe Cys Gly Thr Pro Glu Tyr Val Ala Pro Glu Val Ile Leu Asn 
    610                 615                 620                 


Lys Gly His Asp Phe Ser Val Asp Phe Trp Ser Leu Gly Ile Leu Val 
625                 630                 635                 640 


Tyr Glu Leu Leu Thr Gly Asn Pro Pro Phe Ser Gly Val Asp Gln Met 
                645                 650                 655     


Met Thr Tyr Asn Leu Ile Leu Lys Gly Ile Glu Lys Met Asp Phe Pro 
            660                 665                 670         


Arg Lys Ile Thr Arg Arg Pro Glu Asp Leu Ile Arg Arg Leu Cys Arg 
        675                 680                 685             


Gln Asn Pro Thr Glu Arg Leu Gly Asn Leu Lys Asn Gly Ile Asn Asp 
    690                 695                 700                 


Ile Lys Lys His Arg Trp Leu Asn Gly Phe Asn Trp Glu Gly Leu Lys 
705                 710                 715                 720 


Ala Arg Ser Leu Pro Ser Pro Leu Gln Arg Glu Leu Lys Gly Pro Ile 
                725                 730                 735     


Asp His Ser Tyr Phe Asp Lys Tyr Pro Pro Glu Lys Gly Met Pro Pro 
            740                 745                 750         


Asp Glu Leu Ser Gly Trp Asp Lys Asp Phe 
        755                 760         


<210>  7
<211>  2712
<212>  DNA
<213>  Homo sapiens

<400>  7
atggcaatcc agttccgttc gctcttcccc ttggcattgc ctgggatgct ggcgctcctc       60

ggctggtggt ggtttttctc tcgtaaaaaa ggccatgtca gcagccatga tgagcagcag      120

gtggaggctg gtgctgtgca gctgagggct gaccctgcca tcaaggaacc tctccccgtg      180

gaagacgtct gtcccaaagt agtgtccaca ccccccagtg tcacagagcc tccagaaaag      240

gaactgtcca ccgtgagcaa gctgcctgca gagcccccag cattgctcca gacacaccca      300

ccttgccgaa gatcagagtc ctcgggcatt cttcctaaca ccacagacat gagattgcga      360

ccaggaacac gcagagatga cagtacaaag ctggagctag ccctgacagg tggtgaagcc      420

aaatcgattc ctctagagtg ccccctttca tccccaaagg gtgtactatt ctccagcaaa      480

tcagctgagg tgtgtaagca agattccccc ttcagcaggg tgccaaggaa ggtccagcca      540

ggctaccccg tagtccccgc agagaagcgt agctctgggg agagggcaag agagacaggt      600

ggggccgaag ggactggtga tgccgtgttg ggggaaaagg tgcttgaaga agctctgttg      660

tctcgggagc atgtcttgga attggagaac agcaagggcc ccagcctggc ctctttagag      720

ggggaagaag ataaggggaa gagcagctca tcccaggtgg tggggccagt gcaggaggaa      780

gagtatgtag cagagaagtt gccaagtagg ttcatcgagt cggctcacac agagctggca      840

aaggacgatg cggcgccagc acccccagtc gcagacgcca aagcccagga tagaggtgtc      900

gagggagaac tgggcaatga ggagagcttg gatagaaatg aggagggctt ggatagaaat      960

gaggagggct tggatagaaa tgaggagagc ttggatagaa atgaggaggg cttggataga     1020

aatgaggaga ttaagcgggc tgccttccag ataatctccc aagtgatctc agaagcaacc     1080

gaacaggtgc tggccaccac ggttggcaag gttgcaggtc gtgtgtgtca ggccagtcag     1140

ctccaagggc agaaggaaga gagctgtgtc ccagttcacc agaaaactgt cttgggccca     1200

gacactgcgg agcctgccac agcagaggca gctgttgccc cgccggatgc tggcctcccc     1260

ttgccaggcc taccagcaga gggctcacca ccaccaaaga cctacgtgag ctgcctgaag     1320

agccttctgt ccagccccac caaggacagt aagccaaata tctctgcaca ccacatctcc     1380

ctggcctcct gcctggcact gaccaccccc agtgaagagt tgccggaccg ggcaggcatc     1440

ctggtggaag atgccacctg tgtcacctgc atgtcagaca gcagccaaag tgtccctttg     1500

gtggcttctc caggacactg ctcagattct ttcagcactt cagggcttga agactcttgc     1560

acagagacca gctcgagccc cagggacaag gccatcaccc cgccactgcc agaaagtact     1620

gtgcccttca gcaatggggt gctgaagggg gagttgtcag acttgggggc tgaggatgga     1680

tggaccatgg atgcggaagc agatcattca ggaggttctg acaggaacag catggattcc     1740

gtggatagct gttgcagtct caagaagact gagagcttcc aaaatgccca ggcaggctcc     1800

aaccctaaga aggtcgacct catcatctgg gagatcgagg tgccaaagca cttagtcggt     1860

cggctaattg gcaagcaggg gcgctatgtg agttttctga agcaaacatc tggtgccaag     1920

atctacattt caaccctgcc ttacacccag agcgtccaga tctgccacat agaaggctct     1980

caacatcatg tagacaaagc gctgaacttg attgggaaga agttcaaaga gctgaacctc     2040

accaatatct acgctccccc attgccttca ctggcactgc cttctctgcc gatgacatcc     2100

tggctcatgc tgcctgatgg catcaccgtg gaggtcattg tggtcaacca ggtcaatgcc     2160

gggcacctgt tcgtgcagca gcacacacac cctaccttcc acgcgctgcg cagcctcgac     2220

cagcagatgt acctctgtta ctctcagcct ggaatcccca ccttgcccac cccagtggaa     2280

ataacggtca tctgtgccgc ccctggtgcg gacggggcct ggtggcgagc ccaagtggtt     2340

gcctcctacg aggagaccaa cgaagtggag attcgatacg tggactacgg cggatataag     2400

agggtgaaag tagacgtgct ccggcaaatc aggtctgact ttgtcaccct gccgtttcag     2460

ggagcagaag tccttctgga cagtgtgatg cccctgtcag acgatgacca gttttcaccg     2520

gaagcagatg ccgccatgag cgagatgacg gggaatacag cactgcttgc tcaggtgaca     2580

agttacagtc caactggtct tcctctgatt cagctgtgga gtgtggttgg agatgaagtg     2640

gtgttgataa accggtccct ggtggagcga ggccttgccc agtgggtaga cagctactac     2700

acaagccttt ga                                                         2712


<210>  8
<211>  903
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Ile Gln Phe Arg Ser Leu Phe Pro Leu Ala Leu Pro Gly Met 
1               5                   10                  15      


Leu Ala Leu Leu Gly Trp Trp Trp Phe Phe Ser Arg Lys Lys Gly His 
            20                  25                  30          


Val Ser Ser His Asp Glu Gln Gln Val Glu Ala Gly Ala Val Gln Leu 
        35                  40                  45              


Arg Ala Asp Pro Ala Ile Lys Glu Pro Leu Pro Val Glu Asp Val Cys 
    50                  55                  60                  


Pro Lys Val Val Ser Thr Pro Pro Ser Val Thr Glu Pro Pro Glu Lys 
65                  70                  75                  80  


Glu Leu Ser Thr Val Ser Lys Leu Pro Ala Glu Pro Pro Ala Leu Leu 
                85                  90                  95      


Gln Thr His Pro Pro Cys Arg Arg Ser Glu Ser Ser Gly Ile Leu Pro 
            100                 105                 110         


Asn Thr Thr Asp Met Arg Leu Arg Pro Gly Thr Arg Arg Asp Asp Ser 
        115                 120                 125             


Thr Lys Leu Glu Leu Ala Leu Thr Gly Gly Glu Ala Lys Ser Ile Pro 
    130                 135                 140                 


Leu Glu Cys Pro Leu Ser Ser Pro Lys Gly Val Leu Phe Ser Ser Lys 
145                 150                 155                 160 


Ser Ala Glu Val Cys Lys Gln Asp Ser Pro Phe Ser Arg Val Pro Arg 
                165                 170                 175     


Lys Val Gln Pro Gly Tyr Pro Val Val Pro Ala Glu Lys Arg Ser Ser 
            180                 185                 190         


Gly Glu Arg Ala Arg Glu Thr Gly Gly Ala Glu Gly Thr Gly Asp Ala 
        195                 200                 205             


Val Leu Gly Glu Lys Val Leu Glu Glu Ala Leu Leu Ser Arg Glu His 
    210                 215                 220                 


Val Leu Glu Leu Glu Asn Ser Lys Gly Pro Ser Leu Ala Ser Leu Glu 
225                 230                 235                 240 


Gly Glu Glu Asp Lys Gly Lys Ser Ser Ser Ser Gln Val Val Gly Pro 
                245                 250                 255     


Val Gln Glu Glu Glu Tyr Val Ala Glu Lys Leu Pro Ser Arg Phe Ile 
            260                 265                 270         


Glu Ser Ala His Thr Glu Leu Ala Lys Asp Asp Ala Ala Pro Ala Pro 
        275                 280                 285             


Pro Val Ala Asp Ala Lys Ala Gln Asp Arg Gly Val Glu Gly Glu Leu 
    290                 295                 300                 


Gly Asn Glu Glu Ser Leu Asp Arg Asn Glu Glu Gly Leu Asp Arg Asn 
305                 310                 315                 320 


Glu Glu Gly Leu Asp Arg Asn Glu Glu Ser Leu Asp Arg Asn Glu Glu 
                325                 330                 335     


Gly Leu Asp Arg Asn Glu Glu Ile Lys Arg Ala Ala Phe Gln Ile Ile 
            340                 345                 350         


Ser Gln Val Ile Ser Glu Ala Thr Glu Gln Val Leu Ala Thr Thr Val 
        355                 360                 365             


Gly Lys Val Ala Gly Arg Val Cys Gln Ala Ser Gln Leu Gln Gly Gln 
    370                 375                 380                 


Lys Glu Glu Ser Cys Val Pro Val His Gln Lys Thr Val Leu Gly Pro 
385                 390                 395                 400 


Asp Thr Ala Glu Pro Ala Thr Ala Glu Ala Ala Val Ala Pro Pro Asp 
                405                 410                 415     


Ala Gly Leu Pro Leu Pro Gly Leu Pro Ala Glu Gly Ser Pro Pro Pro 
            420                 425                 430         


Lys Thr Tyr Val Ser Cys Leu Lys Ser Leu Leu Ser Ser Pro Thr Lys 
        435                 440                 445             


Asp Ser Lys Pro Asn Ile Ser Ala His His Ile Ser Leu Ala Ser Cys 
    450                 455                 460                 


Leu Ala Leu Thr Thr Pro Ser Glu Glu Leu Pro Asp Arg Ala Gly Ile 
465                 470                 475                 480 


Leu Val Glu Asp Ala Thr Cys Val Thr Cys Met Ser Asp Ser Ser Gln 
                485                 490                 495     


Ser Val Pro Leu Val Ala Ser Pro Gly His Cys Ser Asp Ser Phe Ser 
            500                 505                 510         


Thr Ser Gly Leu Glu Asp Ser Cys Thr Glu Thr Ser Ser Ser Pro Arg 
        515                 520                 525             


Asp Lys Ala Ile Thr Pro Pro Leu Pro Glu Ser Thr Val Pro Phe Ser 
    530                 535                 540                 


Asn Gly Val Leu Lys Gly Glu Leu Ser Asp Leu Gly Ala Glu Asp Gly 
545                 550                 555                 560 


Trp Thr Met Asp Ala Glu Ala Asp His Ser Gly Gly Ser Asp Arg Asn 
                565                 570                 575     


Ser Met Asp Ser Val Asp Ser Cys Cys Ser Leu Lys Lys Thr Glu Ser 
            580                 585                 590         


Phe Gln Asn Ala Gln Ala Gly Ser Asn Pro Lys Lys Val Asp Leu Ile 
        595                 600                 605             


Ile Trp Glu Ile Glu Val Pro Lys His Leu Val Gly Arg Leu Ile Gly 
    610                 615                 620                 


Lys Gln Gly Arg Tyr Val Ser Phe Leu Lys Gln Thr Ser Gly Ala Lys 
625                 630                 635                 640 


Ile Tyr Ile Ser Thr Leu Pro Tyr Thr Gln Ser Val Gln Ile Cys His 
                645                 650                 655     


Ile Glu Gly Ser Gln His His Val Asp Lys Ala Leu Asn Leu Ile Gly 
            660                 665                 670         


Lys Lys Phe Lys Glu Leu Asn Leu Thr Asn Ile Tyr Ala Pro Pro Leu 
        675                 680                 685             


Pro Ser Leu Ala Leu Pro Ser Leu Pro Met Thr Ser Trp Leu Met Leu 
    690                 695                 700                 


Pro Asp Gly Ile Thr Val Glu Val Ile Val Val Asn Gln Val Asn Ala 
705                 710                 715                 720 


Gly His Leu Phe Val Gln Gln His Thr His Pro Thr Phe His Ala Leu 
                725                 730                 735     


Arg Ser Leu Asp Gln Gln Met Tyr Leu Cys Tyr Ser Gln Pro Gly Ile 
            740                 745                 750         


Pro Thr Leu Pro Thr Pro Val Glu Ile Thr Val Ile Cys Ala Ala Pro 
        755                 760                 765             


Gly Ala Asp Gly Ala Trp Trp Arg Ala Gln Val Val Ala Ser Tyr Glu 
    770                 775                 780                 


Glu Thr Asn Glu Val Glu Ile Arg Tyr Val Asp Tyr Gly Gly Tyr Lys 
785                 790                 795                 800 


Arg Val Lys Val Asp Val Leu Arg Gln Ile Arg Ser Asp Phe Val Thr 
                805                 810                 815     


Leu Pro Phe Gln Gly Ala Glu Val Leu Leu Asp Ser Val Met Pro Leu 
            820                 825                 830         


Ser Asp Asp Asp Gln Phe Ser Pro Glu Ala Asp Ala Ala Met Ser Glu 
        835                 840                 845             


Met Thr Gly Asn Thr Ala Leu Leu Ala Gln Val Thr Ser Tyr Ser Pro 
    850                 855                 860                 


Thr Gly Leu Pro Leu Ile Gln Leu Trp Ser Val Val Gly Asp Glu Val 
865                 870                 875                 880 


Val Leu Ile Asn Arg Ser Leu Val Glu Arg Gly Leu Ala Gln Trp Val 
                885                 890                 895     


Asp Ser Tyr Tyr Thr Ser Leu 
            900             


<210>  9
<211>  11736
<212>  DNA
<213>  Homo sapiens

<400>  9
atggaggacg aggagagaca gaagaagctg gaggccggca aagccaagat tgaagaactc       60

tctttagctt ttcttgtcag acagcttgcc cagtttcgac aaagaaaagc tcagtcggat      120

gggcagagtc cttccaagaa gcagaaaaaa aagagaaaaa cgtcaagcag taaacatgat      180

gtgtcagcac accatgattt gaatattgat caatcacagt gtaatgaaat gtacataaat      240

agttctcaga gagtagaatc aactgtgatt cctgaatcta caataatgag aactctacat      300

agtggagaaa taaccagtca tgagcagggc ttctctgtgg aactggaaag tgaaatttca      360

accacagcag atgactgcag ttcagaggta aatggttgca gttttgtgat gagaacagga      420

aagcctacaa atttattaag ggaagaagaa tttggtgttg atgattctta ttctgaacaa      480

ggagcacaag acagtccgac tcatctagag atgatggaaa gtgagttggc tgggaagcag      540

catgagattg aagagctaaa cagagagctg gaagaaatga gggttaccta tgggactgaa      600

ggactgcagc agttacaaga atttgaagct gccattaaac aaagagatgg cattataacc      660

cagctcactg ctaatttaca acaagcaaga agagaaaagg atgagacaat gagagaattt      720

ttagagttga cagaacagag tcaaaaatta cagattcaat ttcagcaatt acaggctagt      780

gaaactctga gaaacagcac tcatagtagc acagctgcag acttactaca agccaaacaa      840

cagatcctca ctcatcaaca gcagcttgaa gaacaagacc acttattaga agattatcag      900

aaaaagaaag aagacttcac aatgcaaatt agtttcttgc aagagaaaat taaagtatat      960

gaaatggaac aagataaaaa agtagaaaac tcaaataaag aagaaataca ggaaaaggag     1020

acaatcattg aagaattaaa cacaaaaata atagaagaag aaaagaaaac tcttgagcta     1080

aaggataaat taacaactgc tgataaatta ctaggagaat tacaagaaca gattgtgcaa     1140

aagaaccaag aaataaaaaa catgaaatta gagctgacta attctaagca aaaagaaaga     1200

cagtcttctg aagaaataaa acagttaatg gggacagtcg aagaacttca gaagagaaat     1260

cataaagaca gccagttcga aactgatata gtacaacgaa tggaacaaga aacacaaaga     1320

aagttagaac aactccgggc agagctggat gagatgtatg ggcagcagat agtgcaaatg     1380

aaacaagaat taataagaca acacatggca cagatggagg aaatgaaaac acggcataag     1440

ggagaaatgg agaatgcttt aaggtcatat tcaaatatta cagttaatga agatcagata     1500

aagttaatga atgtggcaat aaatgaactg aatataaaat tgcaagatac taactctcaa     1560

aaggaaaaac tcaaggaaga actaggacta attttagaag aaaagtgtgc tctacagaga     1620

cagcttgaag accttgttga agaattgagc ttttcaaggg aacagattca gagagctaga     1680

cagacaatag ctgaacaaga aagtaaactt aatgaagcac ataagtccct tagtacagtg     1740

gaagatttga aagctgagat tgtttctgca tctgaatcca gaaaggaact agaattaaaa     1800

catgaagcag aagttacaaa ttacaagata aaacttgaaa tgttagaaaa agaaaagaat     1860

gctgtgttag acagaatggc tgaatcacaa gaagctgaat tagagaggct gagaacacag     1920

cttctattta gtcacgaaga agagctttcc aaactgaagg aagatttaga aattgaacat     1980

cgaataaata ttgaaaaact taaagataat ttaggcattc actataaaca gcagatagat     2040

ggtttacaga atgaaatgag tcaaaagata gaaaccatgc agtttgaaaa ggacaatttg     2100

ataactaagc agaatcaatt aattttggaa atttcaaagc taaaagattt acagcagtct     2160

cttgtaaatt caaagtcaga agaaatgact cttcaaatca atgaacttca aaaagaaatt     2220

gaaatactca gacaagaaga aaaagaaaag ggtacacttg aacaagaagt tcaagaatta     2280

caacttaaaa cagaattgtt agaaaaacag atgaaggaaa aagagaatga tcttcaagaa     2340

aaatttgcac aacttgaagc agagaatagc attcttaaag atgaaaagaa aacccttgaa     2400

gacatgttga aaatacatac tcctgttagc caagaagaaa gattgatttt cttagactcc     2460

attaagtcca aatccaaaga ctctgtgtgg gaaaaagaaa tagaaatact tatagaggaa     2520

aatgaggacc tcaaacaaca atgtattcag ctaaatgaag agattgaaaa gcaaaggaac     2580

actttttcat ttgctgaaaa aaactttgaa gttaactatc aagagttaca agaggagtat     2640

gcttgccttc tcaaagtaaa agatgattta gaagacagta aaaataaaca ggaattagag     2700

tataaaagta aacttaaagc acttaatgaa gagcttcatt tgcaaagaat aaatccaact     2760

acagtgaaaa tgaaaagttc tgtctttgat gaagacaaaa cttttgtagc agaaacattg     2820

gaaatgggtg aggttgttga aaaggataca acagaactca tggaaaaact tgaggtaacc     2880

aagcgagaga aattagagct gtcacagaga ctgtctgatc tttctgaaca attgaaacag     2940

aaacatggtg agattagttt tctaaatgaa gaagttaaat ctttaaagca agagaaagaa     3000

caagtttcat tgagatgtag agagctagaa atcattatta accacaacag ggcagaaaat     3060

gtacagtcat gtgatactca agtaagctct ttattagatg gagttgtgac catgacaagc     3120

aggggtgctg aaggatcagt ttctaaagta aataaaagtt ttggtgaaga atcaaaaata     3180

atggtggaag ataaagtttc ttttgaaaat atgactgttg gagaagaaag taagcaagaa     3240

cagttgattt tggatcactt accatctgta acaaaggaat catcacttag agcaactcaa     3300

ccaagtgaaa atgataaact tcagaaagaa ctcaatgtac ttaaatcaga acagaatgat     3360

ttaaggctac agatggaagc ccaacgcatt tgcctctctc tggtttattc aactcatgtg     3420

gatcaggttc gtgaatatat ggaaaatgaa aaagataaag ctctttgcag tcttaaagaa     3480

gagcttattt ttgctcaaga ggaaaagatc aaggaacttc agaaaataca ccagttagaa     3540

ctacagacta tgaaaacaca agaaacaggt gatgaaggaa agcctttaca tctgctcatt     3600

ggaaaacttc aaaaggcagt gtctgaagaa tgttcttatt ttttacagac tttatgcagt     3660

gtccttggtg aatattatac tcctgcttta aaatgtgaag taaatgcaga agacaaagag     3720

aattctggtg attacatttc tgaaaatgaa gatccagaat tacaagatta tagatatgaa     3780

gttcaagact ttcaagaaaa tatgcacact cttctcaaca aagtaacaga agaatacaac     3840

aaactcttgg tacttcaaac acgactaagc aagatctggg gacagcagac agatggtatg     3900

aaacttgaat ttggagaaga aaaccttcca aaagaggaaa cagagttttt atcaatccat     3960

tctcagatga ccaatttgga agacattgat gtcaatcata aaagcaagtt atcttctctg     4020

caagatcttg aaaaaactaa acttgaagaa caagttcaag aattagaaag cctcatatcc     4080

tctttgcagc aacagttgaa agaaactgaa caaaactatg aggcagagat ccactgttta     4140

cagaagaggc ttcaagctgt tagtgagtcc acggttccgc caagcttacc tgttgattcg     4200

gtggtaatta cagaatctga tgcacagaga acaatgtacc ctggaagttg tgtgaaaaag     4260

aatattgatg gtacaataga gttttctggt gaatttggag tgaaagagga aacaaatatc     4320

gttaagttgc ttgaaaaaca ataccaagaa caattagaag aagaagtagc taaggttatt     4380

gtgtcaatga gtatagcatt tgctcaacaa actgaactgt ctagaatatc tgggggaaaa     4440

gaaaatactg catcatcaaa gcaagcacat gctgtgtgtc agcaagaaca acattatttt     4500

aatgaaatga aattatcaca ggatcaaatt ggttttcaga cttttgagac agtggatgtg     4560

aaatttaaag aagaatttaa accacttagt aaagagttag gagaacatgg aaaggaaatt     4620

ttattatcaa atagtgatcc ccatgatata ccagaatcaa aggactgtgt gctgactatt     4680

tcagaagaaa tgttctccaa agataaaaca tttatagtta gacagtctat tcatgatgag     4740

atttcagtgt caagcatgga tgcttctaga caactaatgt tgaatgaaga acagttggaa     4800

gatatgagac aggaacttgt acgacaatac caagaacatc aacaggcaac ggaattgtta     4860

aggcaagcac atatgcggca aatggagaga cagcgagaag accaggaaca gctacaagaa     4920

gagattaaga gacttaatag acaattagcc cagagatcct ccatagataa tgaaaacctg     4980

gtttcagaga gagagagggt gcttttagag gagctggaag cactaaagca gctgtcttta     5040

gctggaagag agaagctgtg ttgtgagctg cgcaacagca gtacgcaaac acagaatgga     5100

aatgaaaacc aaggagaagt tgaagaacaa acatttaaag aaaaggaatt agacagaaaa     5160

cctgaagatg tgcctcctga gattttgtct aatgaaaggt atgcactcca gaaagctaat     5220

aatagacttt tgaagatcct cttagaagtt gtaaagacaa cagcagctgt tgaagaaaca     5280

attggtcgcc atgtccttgg gattctagat agatctagta aaagccagtc atctgccagc     5340

ctaatttgga ggtcagaagc agaggcatct gtaaagtcat gtgtccatga ggaacataca     5400

agagttacag atgaatccat tccctcttat tctggaagtg atatgccaag aaatgacatt     5460

aacatgtggt caaaagtaac tgaggaagga acagagctgt cacaacgact tgtgaggagt     5520

ggttttgctg gaactgaaat agaccctgaa aatgaagaac ttatgctgaa cattagctct     5580

cgactacaag cagcagttga aaaactccta gaagccataa gtgaaactag cagtcagctt     5640

gaacatgcga aagtgacaca gacagagttg atgcgtgagt catttagaca gaaacaagaa     5700

gcaacagagt cccttaagtg ccaagaggaa cttcgagagc gccttcatga ggagtccagg     5760

gccagagaac agctagctgt ggagctcagt aaggctgagg gcgtcattga tggctatgca     5820

gatgaaaaaa ctctttttga aaggcaaatt caggaaaaaa ctgatataat agatcgtctt     5880

gagcaggagt tgttatgtgc aagtaacagg ttgcaagaat tggaggcaga gcaacagcag     5940

atccaagaag aaagagaatt actgtccaga caaaaggaag ctatgaaagc agaggcaggc     6000

ccagttgaac aacaattact acaggagaca gaaaaattaa tgaaggaaaa actagaagta     6060

caatgtcaag ctgaaaaagt acgtgatgac cttcaaaaac aagtgaaagc tctagaaata     6120

gatgtggaag aacaagtcag taggtttata gagctggaac aagaaaaaaa tactgaacta     6180

atggatttaa gacagcaaaa ccaagcattg gaaaagcagt tagaaaaaat gagaaaattt     6240

ttagatgagc aagccattga cagagaacat gagagagatg tattccaaca ggaaatacag     6300

aaactagaac agcaacttaa ggttgttcct cgattccagc ctatcagtga acatcaaact     6360

agagaggttg aacagttagc aaatcatctg aaagaaaaaa cagacaaatg cagtgagctt     6420

ttgctctcta aagagcagct tcaaagggat atacaagaaa ggaatgaaga aatagagaaa     6480

ctggagttca gagtaagaga actggagcag gcgcttcttg tgagtgcaga tacttttcaa     6540

aaggtagagg accgaaaaca ctttggagct gtagaagcta aaccagaatt gtccctagaa     6600

gtacaattgc aggctgaacg agatgccata gacagaaagg aaaaagagat tacaaactta     6660

gaagagcaat tagaacagtt tagagaagaa ctggaaaata agaatgaaga agttcaacaa     6720

ttacatatgc aattagaaat acagaaaaag gaatctacta cccgcctaca agaacttgaa     6780

caggaaaaca aattatttaa ggatgacatg gagaaactgg gacttgccat aaaggaatct     6840

gatgccatgt ctactcaaga ccaacatgtg ctatttggga aatttgctca aataatacag     6900

gaaaaagagg tagaaattga ccaattaaat gaacaagtta cgaaactcca gcagcaactt     6960

aaaattacaa cagataacaa ggttattgaa gaaaaaaatg aactgataag ggatcttgaa     7020

acccaaatag aatgtttgat gagtgatcaa gaatgtgtga agagaaatag agaagaagaa     7080

atagagcagc tcaatgaagt gattgaaaaa cttcaacagg aattggcaaa tattggacag     7140

aagacatcaa tgaatgctca ttccctctca gaagaagcag acagtttaaa acatcaattg     7200

gatgtggtta tagctgaaaa gctggccttg gaacagcaag tagaaaccgc taatgaagaa     7260

atgaccttca tgaaaaatgt acttaaagaa accaatttta aaatgaatca gctaacacag     7320

gaattattca gcttaaagag agaacgtgaa agtgtggaaa agattcaaag cataccagag     7380

aatagtgtta acgtggctat agatcatctg agcaaagaca aacctgaact agaagtagtc     7440

cttacagagg atgctcttaa atccctagaa aatcagacat acttcaaatc ttttgaagaa     7500

aatggcaaag gttccataat taatttggaa acaaggttgc tacaacttga gagcactgtt     7560

agtgcaaagg acttagaact tacccagtgt tataaacaaa taaaagacat gcaagaacaa     7620

ggccagtttg aaacagaaat gcttcaaaag aagattgtaa acctacagaa aatagttgaa     7680

gaaaaagtgg ctgctgctct tgtcagtcaa atccaacttg aggcagttca ggaatatgca     7740

aaattctgtc aagataatca aacaatttca tcagaacctg aaagaacaaa tattcagaat     7800

ttaaatcaac taagagaaga tgagttgggg tcagatatat cagcattaac cttgagaata     7860

tcagaattag aaagccaggt tgttgaaatg catactagtt tgattttaga aaaagaacaa     7920

gtagaaattg cagaaaaaaa tgttttagaa aaagaaaaga agctgctaga actacagaag     7980

ctattggagg gcaatgagaa aaaacagaga gagaaagaaa agaaaagaag ccctcaagat     8040

gttgaagttc tcaagacaac tactgagcta tttcatagca atgaagaaag tggatttttt     8100

aatgaactcg aggctcttag agctgaatca gtggctacca aagcagaact tgccagttat     8160

aaagaaaagg ctgaaaaact tcaagaagag cttttggtaa aagaaacaaa tatgacatct     8220

cttcagaaag acttaagcca agttagggat cacctcgcag aggcaaaaga gaaattgtcc     8280

attttagaaa aagaagatga gactgaggta caagaaagca aaaaggcctg catgtttgag     8340

ccacttccta taaaactgag taagagcatt gcatcccaga cagatgggac tctgaagatc     8400

agtagcagca atcagactcc acaaattctt gttaaaaatg caggaataca aattaattta     8460

cagagtgaat gttcctcaga agaagttact gaaataatca gtcagtttac tgaaaaaatt     8520

gagaagatgc aagaactaca tgctgctgaa attttggaca tggaatccag acatatttca     8580

gaaactgaaa ccttaaagag ggaacactat gttgccgttc agttactgaa agaggaatgt     8640

ggtaccttga aggcagtgat acagtgtctg agaagtaaag aggtatttgg tttttataat     8700

atgtgttttt caacattgtg tgattctgga tcagactggg gtcagggaat ttatcttaca     8760

cacagtcagg gatttgacat agcatcagaa ggccgaggag aagaaagtga aagtgcaaca     8820

gattcctttc caaagaaaat aaagggatta ctgagagctg tccataatga aggcatgcag     8880

gtgctttctc tcactgagtc tccctatagt gatggagagg accattctat tcagcaggtt     8940

tcagaacctt ggctagaaga gagaaaagct tacatcaata caatctcatc tctaaaggat     9000

ttaattacaa agatgcaact gcaaagagaa gccgaggttt atgatagttc tcaatctcat     9060

gagagcttct cagactggcg aggtgaacta ctgcttgccc ttcaacaagt tttcttagaa     9120

gagcgtagtg ttttactagc agcatttcgg acggagctga cagctctagg tactacagat     9180

gcagttggtt tactaaactg tttggaacag agaatacaag aacagggtgt tgaatatcaa     9240

gcagctatgg aatgcctcca gaaagcagat agaaggagtt tgttatctga aattcaggca     9300

ctgcatgcac aaatgaatgg taggaaaatt actctgaaaa gagaacaaga gagtgagaaa     9360

ccaagccaag aactcttgga atataatata cagcagaagc agtctcaaat gctggagatg     9420

caagtggagc tcagcagtat gaaagacaga gcaacggaac tgcaggagca gctgagttct     9480

gagaaaatgg tggttgctga actgaagagt gagcttgcac aaactaaatt ggaactagaa     9540

acaacactca aggcacagca taaacaccta aaagaattgg aggctttcag gttggaagtt     9600

aaagataaga cagatgaagt acatttgctt aatgacacat tagcaagtga acagaaaaaa     9660

tcaagagagc tccagtgggc tttggagaaa gagaaagcca agttgggacg cagtgaagaa     9720

cgggataaag aagaacttga ggatctgaag ttttcacttg agagtcagaa acaaaggaat     9780

cttcagctaa atctactttt ggaacaacag aaacaactac tgaacgaatc ccagcaaaaa     9840

atagaatcac agagaatgct atatgatgcc cagttgtcag aagaacaagg tcgaaactta     9900

gagcttcagg tacttcttga atctgagaaa gttcgaattc gggaaatgag tagtacccta     9960

gatagggagc gggaattgca cgcacagctg cagagcagtg atggtactgg acagtctcgg    10020

ccacccttgc cctcagagga cctactgaaa gagctgcaga aacagctaga ggaaaaacac    10080

agtcgcatag tagaattgtt aaatgagact gaaaaatata aactggattc tttgcaaaca    10140

cgacagcaaa tggaaaaaga taggcaggtt cacaggaaaa cactgcagac agaacaggag    10200

gccaacactg agggacagaa aaaaatgcat gagctccagt ccaaagtgga agatcttcag    10260

cgccagctgg aagagaaaag acaacaagtt tataagttag accttgaagg acagcgacta    10320

caaggaatca tgcaggaatt ccagaagcaa gaactagaac gagaagaaaa acgagaaagt    10380

agaagaattc tgtatcagaa ccttaatgag ccaaccacgt ggagcttaac cagtgataga    10440

actagaaatt gggttcttca acagaaaata gaaggagaaa caaaagaatc aaactacgct    10500

aaattgattg aaatgaatgg aggaggaacc ggctgtaatc atgaattaga aatgatcaga    10560

caaaagcttc aatgtgtagc ttcaaaacta caggttctac cccagaaagc ctctgagaga    10620

ctacagtttg aaacagcaga tgatgaagat ttcatttggg ttcaggaaaa tattgatgaa    10680

attattttac aactacagaa attaactggc cagcaaggtg aagagcccag cttggtgtcc    10740

ccaagtactt cttgtggctc attgactgaa agactactga gacaaaatgc tgagctgaca    10800

gggcatatca gtcaactgac tgaagagaag aatgacttaa ggaacatggt tatgaagctg    10860

gaagagcaga tcaggtggta tcgacagaca ggagctggta gagataattc ttccaggttt    10920

tcattgaatg gtggtgccaa cattgaagcc atcattgcct ctgaaaaaga agtatggaac    10980

agagaaaaat tgactctcca gaaatctttg aaaagggcag aggctgaagt atacaaactg    11040

aaagctgaac taagaaatga ctctttactt caaactctga gccctgattc tgaacatgtc    11100

actttaaaga gaatttatgg taaatacttg agggcagaaa gttttcgaaa ggctctcatt    11160

taccagaaga aatacctgct gctgttactg ggtgggttcc aggaatgtga agatgccacc    11220

ttggccctgc ttgcccggat gggggggcag ccagctttca cggatctaga ggtgatcacc    11280

aatcgcccaa agggcttcac caggtttcgg tcggccgtca gagtatccat tgcaatttcc    11340

agaatgaaat ttttggttcg acggtggcat cgagtcacag gttctgtttc catcaatatt    11400

aacagagatg gctttggact gaatcaaggt gcagaaaaga ctgactcatt ttatcattct    11460

tctggtgggc tggagttata tggagaacca agacatacta cgtatcgctc aagatcagat    11520

ctggactata ttaggtcccc tttaccattt cagaataggt acccaggcac tccagctgat    11580

ttcaatcctg gttctttagc atgttctcag cttcagaatt acgatcctga cagagcccta    11640

acagattata tcactcggct agaggcactg caaagacgac ttggaactat acagtcaggt    11700

tcaactactc aatttcatgc tggcatgaga agataa                              11736


<210>  10
<211>  3911
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Glu Asp Glu Glu Arg Gln Lys Lys Leu Glu Ala Gly Lys Ala Lys 
1               5                   10                  15      


Ile Glu Glu Leu Ser Leu Ala Phe Leu Val Arg Gln Leu Ala Gln Phe 
            20                  25                  30          


Arg Gln Arg Lys Ala Gln Ser Asp Gly Gln Ser Pro Ser Lys Lys Gln 
        35                  40                  45              


Lys Lys Lys Arg Lys Thr Ser Ser Ser Lys His Asp Val Ser Ala His 
    50                  55                  60                  


His Asp Leu Asn Ile Asp Gln Ser Gln Cys Asn Glu Met Tyr Ile Asn 
65                  70                  75                  80  


Ser Ser Gln Arg Val Glu Ser Thr Val Ile Pro Glu Ser Thr Ile Met 
                85                  90                  95      


Arg Thr Leu His Ser Gly Glu Ile Thr Ser His Glu Gln Gly Phe Ser 
            100                 105                 110         


Val Glu Leu Glu Ser Glu Ile Ser Thr Thr Ala Asp Asp Cys Ser Ser 
        115                 120                 125             


Glu Val Asn Gly Cys Ser Phe Val Met Arg Thr Gly Lys Pro Thr Asn 
    130                 135                 140                 


Leu Leu Arg Glu Glu Glu Phe Gly Val Asp Asp Ser Tyr Ser Glu Gln 
145                 150                 155                 160 


Gly Ala Gln Asp Ser Pro Thr His Leu Glu Met Met Glu Ser Glu Leu 
                165                 170                 175     


Ala Gly Lys Gln His Glu Ile Glu Glu Leu Asn Arg Glu Leu Glu Glu 
            180                 185                 190         


Met Arg Val Thr Tyr Gly Thr Glu Gly Leu Gln Gln Leu Gln Glu Phe 
        195                 200                 205             


Glu Ala Ala Ile Lys Gln Arg Asp Gly Ile Ile Thr Gln Leu Thr Ala 
    210                 215                 220                 


Asn Leu Gln Gln Ala Arg Arg Glu Lys Asp Glu Thr Met Arg Glu Phe 
225                 230                 235                 240 


Leu Glu Leu Thr Glu Gln Ser Gln Lys Leu Gln Ile Gln Phe Gln Gln 
                245                 250                 255     


Leu Gln Ala Ser Glu Thr Leu Arg Asn Ser Thr His Ser Ser Thr Ala 
            260                 265                 270         


Ala Asp Leu Leu Gln Ala Lys Gln Gln Ile Leu Thr His Gln Gln Gln 
        275                 280                 285             


Leu Glu Glu Gln Asp His Leu Leu Glu Asp Tyr Gln Lys Lys Lys Glu 
    290                 295                 300                 


Asp Phe Thr Met Gln Ile Ser Phe Leu Gln Glu Lys Ile Lys Val Tyr 
305                 310                 315                 320 


Glu Met Glu Gln Asp Lys Lys Val Glu Asn Ser Asn Lys Glu Glu Ile 
                325                 330                 335     


Gln Glu Lys Glu Thr Ile Ile Glu Glu Leu Asn Thr Lys Ile Ile Glu 
            340                 345                 350         


Glu Glu Lys Lys Thr Leu Glu Leu Lys Asp Lys Leu Thr Thr Ala Asp 
        355                 360                 365             


Lys Leu Leu Gly Glu Leu Gln Glu Gln Ile Val Gln Lys Asn Gln Glu 
    370                 375                 380                 


Ile Lys Asn Met Lys Leu Glu Leu Thr Asn Ser Lys Gln Lys Glu Arg 
385                 390                 395                 400 


Gln Ser Ser Glu Glu Ile Lys Gln Leu Met Gly Thr Val Glu Glu Leu 
                405                 410                 415     


Gln Lys Arg Asn His Lys Asp Ser Gln Phe Glu Thr Asp Ile Val Gln 
            420                 425                 430         


Arg Met Glu Gln Glu Thr Gln Arg Lys Leu Glu Gln Leu Arg Ala Glu 
        435                 440                 445             


Leu Asp Glu Met Tyr Gly Gln Gln Ile Val Gln Met Lys Gln Glu Leu 
    450                 455                 460                 


Ile Arg Gln His Met Ala Gln Met Glu Glu Met Lys Thr Arg His Lys 
465                 470                 475                 480 


Gly Glu Met Glu Asn Ala Leu Arg Ser Tyr Ser Asn Ile Thr Val Asn 
                485                 490                 495     


Glu Asp Gln Ile Lys Leu Met Asn Val Ala Ile Asn Glu Leu Asn Ile 
            500                 505                 510         


Lys Leu Gln Asp Thr Asn Ser Gln Lys Glu Lys Leu Lys Glu Glu Leu 
        515                 520                 525             


Gly Leu Ile Leu Glu Glu Lys Cys Ala Leu Gln Arg Gln Leu Glu Asp 
    530                 535                 540                 


Leu Val Glu Glu Leu Ser Phe Ser Arg Glu Gln Ile Gln Arg Ala Arg 
545                 550                 555                 560 


Gln Thr Ile Ala Glu Gln Glu Ser Lys Leu Asn Glu Ala His Lys Ser 
                565                 570                 575     


Leu Ser Thr Val Glu Asp Leu Lys Ala Glu Ile Val Ser Ala Ser Glu 
            580                 585                 590         


Ser Arg Lys Glu Leu Glu Leu Lys His Glu Ala Glu Val Thr Asn Tyr 
        595                 600                 605             


Lys Ile Lys Leu Glu Met Leu Glu Lys Glu Lys Asn Ala Val Leu Asp 
    610                 615                 620                 


Arg Met Ala Glu Ser Gln Glu Ala Glu Leu Glu Arg Leu Arg Thr Gln 
625                 630                 635                 640 


Leu Leu Phe Ser His Glu Glu Glu Leu Ser Lys Leu Lys Glu Asp Leu 
                645                 650                 655     


Glu Ile Glu His Arg Ile Asn Ile Glu Lys Leu Lys Asp Asn Leu Gly 
            660                 665                 670         


Ile His Tyr Lys Gln Gln Ile Asp Gly Leu Gln Asn Glu Met Ser Gln 
        675                 680                 685             


Lys Ile Glu Thr Met Gln Phe Glu Lys Asp Asn Leu Ile Thr Lys Gln 
    690                 695                 700                 


Asn Gln Leu Ile Leu Glu Ile Ser Lys Leu Lys Asp Leu Gln Gln Ser 
705                 710                 715                 720 


Leu Val Asn Ser Lys Ser Glu Glu Met Thr Leu Gln Ile Asn Glu Leu 
                725                 730                 735     


Gln Lys Glu Ile Glu Ile Leu Arg Gln Glu Glu Lys Glu Lys Gly Thr 
            740                 745                 750         


Leu Glu Gln Glu Val Gln Glu Leu Gln Leu Lys Thr Glu Leu Leu Glu 
        755                 760                 765             


Lys Gln Met Lys Glu Lys Glu Asn Asp Leu Gln Glu Lys Phe Ala Gln 
    770                 775                 780                 


Leu Glu Ala Glu Asn Ser Ile Leu Lys Asp Glu Lys Lys Thr Leu Glu 
785                 790                 795                 800 


Asp Met Leu Lys Ile His Thr Pro Val Ser Gln Glu Glu Arg Leu Ile 
                805                 810                 815     


Phe Leu Asp Ser Ile Lys Ser Lys Ser Lys Asp Ser Val Trp Glu Lys 
            820                 825                 830         


Glu Ile Glu Ile Leu Ile Glu Glu Asn Glu Asp Leu Lys Gln Gln Cys 
        835                 840                 845             


Ile Gln Leu Asn Glu Glu Ile Glu Lys Gln Arg Asn Thr Phe Ser Phe 
    850                 855                 860                 


Ala Glu Lys Asn Phe Glu Val Asn Tyr Gln Glu Leu Gln Glu Glu Tyr 
865                 870                 875                 880 


Ala Cys Leu Leu Lys Val Lys Asp Asp Leu Glu Asp Ser Lys Asn Lys 
                885                 890                 895     


Gln Glu Leu Glu Tyr Lys Ser Lys Leu Lys Ala Leu Asn Glu Glu Leu 
            900                 905                 910         


His Leu Gln Arg Ile Asn Pro Thr Thr Val Lys Met Lys Ser Ser Val 
        915                 920                 925             


Phe Asp Glu Asp Lys Thr Phe Val Ala Glu Thr Leu Glu Met Gly Glu 
    930                 935                 940                 


Val Val Glu Lys Asp Thr Thr Glu Leu Met Glu Lys Leu Glu Val Thr 
945                 950                 955                 960 


Lys Arg Glu Lys Leu Glu Leu Ser Gln Arg Leu Ser Asp Leu Ser Glu 
                965                 970                 975     


Gln Leu Lys Gln Lys His Gly Glu Ile Ser Phe Leu Asn Glu Glu Val 
            980                 985                 990         


Lys Ser Leu Lys Gln Glu Lys Glu  Gln Val Ser Leu Arg  Cys Arg Glu 
        995                 1000                 1005             


Leu Glu  Ile Ile Ile Asn His  Asn Arg Ala Glu Asn  Val Gln Ser 
    1010                 1015                 1020             


Cys Asp  Thr Gln Val Ser Ser  Leu Leu Asp Gly Val  Val Thr Met 
    1025                 1030                 1035             


Thr Ser  Arg Gly Ala Glu Gly  Ser Val Ser Lys Val  Asn Lys Ser 
    1040                 1045                 1050             


Phe Gly  Glu Glu Ser Lys Ile  Met Val Glu Asp Lys  Val Ser Phe 
    1055                 1060                 1065             


Glu Asn  Met Thr Val Gly Glu  Glu Ser Lys Gln Glu  Gln Leu Ile 
    1070                 1075                 1080             


Leu Asp  His Leu Pro Ser Val  Thr Lys Glu Ser Ser  Leu Arg Ala 
    1085                 1090                 1095             


Thr Gln  Pro Ser Glu Asn Asp  Lys Leu Gln Lys Glu  Leu Asn Val 
    1100                 1105                 1110             


Leu Lys  Ser Glu Gln Asn Asp  Leu Arg Leu Gln Met  Glu Ala Gln 
    1115                 1120                 1125             


Arg Ile  Cys Leu Ser Leu Val  Tyr Ser Thr His Val  Asp Gln Val 
    1130                 1135                 1140             


Arg Glu  Tyr Met Glu Asn Glu  Lys Asp Lys Ala Leu  Cys Ser Leu 
    1145                 1150                 1155             


Lys Glu  Glu Leu Ile Phe Ala  Gln Glu Glu Lys Ile  Lys Glu Leu 
    1160                 1165                 1170             


Gln Lys  Ile His Gln Leu Glu  Leu Gln Thr Met Lys  Thr Gln Glu 
    1175                 1180                 1185             


Thr Gly  Asp Glu Gly Lys Pro  Leu His Leu Leu Ile  Gly Lys Leu 
    1190                 1195                 1200             


Gln Lys  Ala Val Ser Glu Glu  Cys Ser Tyr Phe Leu  Gln Thr Leu 
    1205                 1210                 1215             


Cys Ser  Val Leu Gly Glu Tyr  Tyr Thr Pro Ala Leu  Lys Cys Glu 
    1220                 1225                 1230             


Val Asn  Ala Glu Asp Lys Glu  Asn Ser Gly Asp Tyr  Ile Ser Glu 
    1235                 1240                 1245             


Asn Glu  Asp Pro Glu Leu Gln  Asp Tyr Arg Tyr Glu  Val Gln Asp 
    1250                 1255                 1260             


Phe Gln  Glu Asn Met His Thr  Leu Leu Asn Lys Val  Thr Glu Glu 
    1265                 1270                 1275             


Tyr Asn  Lys Leu Leu Val Leu  Gln Thr Arg Leu Ser  Lys Ile Trp 
    1280                 1285                 1290             


Gly Gln  Gln Thr Asp Gly Met  Lys Leu Glu Phe Gly  Glu Glu Asn 
    1295                 1300                 1305             


Leu Pro  Lys Glu Glu Thr Glu  Phe Leu Ser Ile His  Ser Gln Met 
    1310                 1315                 1320             


Thr Asn  Leu Glu Asp Ile Asp  Val Asn His Lys Ser  Lys Leu Ser 
    1325                 1330                 1335             


Ser Leu  Gln Asp Leu Glu Lys  Thr Lys Leu Glu Glu  Gln Val Gln 
    1340                 1345                 1350             


Glu Leu  Glu Ser Leu Ile Ser  Ser Leu Gln Gln Gln  Leu Lys Glu 
    1355                 1360                 1365             


Thr Glu  Gln Asn Tyr Glu Ala  Glu Ile His Cys Leu  Gln Lys Arg 
    1370                 1375                 1380             


Leu Gln  Ala Val Ser Glu Ser  Thr Val Pro Pro Ser  Leu Pro Val 
    1385                 1390                 1395             


Asp Ser  Val Val Ile Thr Glu  Ser Asp Ala Gln Arg  Thr Met Tyr 
    1400                 1405                 1410             


Pro Gly  Ser Cys Val Lys Lys  Asn Ile Asp Gly Thr  Ile Glu Phe 
    1415                 1420                 1425             


Ser Gly  Glu Phe Gly Val Lys  Glu Glu Thr Asn Ile  Val Lys Leu 
    1430                 1435                 1440             


Leu Glu  Lys Gln Tyr Gln Glu  Gln Leu Glu Glu Glu  Val Ala Lys 
    1445                 1450                 1455             


Val Ile  Val Ser Met Ser Ile  Ala Phe Ala Gln Gln  Thr Glu Leu 
    1460                 1465                 1470             


Ser Arg  Ile Ser Gly Gly Lys  Glu Asn Thr Ala Ser  Ser Lys Gln 
    1475                 1480                 1485             


Ala His  Ala Val Cys Gln Gln  Glu Gln His Tyr Phe  Asn Glu Met 
    1490                 1495                 1500             


Lys Leu  Ser Gln Asp Gln Ile  Gly Phe Gln Thr Phe  Glu Thr Val 
    1505                 1510                 1515             


Asp Val  Lys Phe Lys Glu Glu  Phe Lys Pro Leu Ser  Lys Glu Leu 
    1520                 1525                 1530             


Gly Glu  His Gly Lys Glu Ile  Leu Leu Ser Asn Ser  Asp Pro His 
    1535                 1540                 1545             


Asp Ile  Pro Glu Ser Lys Asp  Cys Val Leu Thr Ile  Ser Glu Glu 
    1550                 1555                 1560             


Met Phe  Ser Lys Asp Lys Thr  Phe Ile Val Arg Gln  Ser Ile His 
    1565                 1570                 1575             


Asp Glu  Ile Ser Val Ser Ser  Met Asp Ala Ser Arg  Gln Leu Met 
    1580                 1585                 1590             


Leu Asn  Glu Glu Gln Leu Glu  Asp Met Arg Gln Glu  Leu Val Arg 
    1595                 1600                 1605             


Gln Tyr  Gln Glu His Gln Gln  Ala Thr Glu Leu Leu  Arg Gln Ala 
    1610                 1615                 1620             


His Met  Arg Gln Met Glu Arg  Gln Arg Glu Asp Gln  Glu Gln Leu 
    1625                 1630                 1635             


Gln Glu  Glu Ile Lys Arg Leu  Asn Arg Gln Leu Ala  Gln Arg Ser 
    1640                 1645                 1650             


Ser Ile  Asp Asn Glu Asn Leu  Val Ser Glu Arg Glu  Arg Val Leu 
    1655                 1660                 1665             


Leu Glu  Glu Leu Glu Ala Leu  Lys Gln Leu Ser Leu  Ala Gly Arg 
    1670                 1675                 1680             


Glu Lys  Leu Cys Cys Glu Leu  Arg Asn Ser Ser Thr  Gln Thr Gln 
    1685                 1690                 1695             


Asn Gly  Asn Glu Asn Gln Gly  Glu Val Glu Glu Gln  Thr Phe Lys 
    1700                 1705                 1710             


Glu Lys  Glu Leu Asp Arg Lys  Pro Glu Asp Val Pro  Pro Glu Ile 
    1715                 1720                 1725             


Leu Ser  Asn Glu Arg Tyr Ala  Leu Gln Lys Ala Asn  Asn Arg Leu 
    1730                 1735                 1740             


Leu Lys  Ile Leu Leu Glu Val  Val Lys Thr Thr Ala  Ala Val Glu 
    1745                 1750                 1755             


Glu Thr  Ile Gly Arg His Val  Leu Gly Ile Leu Asp  Arg Ser Ser 
    1760                 1765                 1770             


Lys Ser  Gln Ser Ser Ala Ser  Leu Ile Trp Arg Ser  Glu Ala Glu 
    1775                 1780                 1785             


Ala Ser  Val Lys Ser Cys Val  His Glu Glu His Thr  Arg Val Thr 
    1790                 1795                 1800             


Asp Glu  Ser Ile Pro Ser Tyr  Ser Gly Ser Asp Met  Pro Arg Asn 
    1805                 1810                 1815             


Asp Ile  Asn Met Trp Ser Lys  Val Thr Glu Glu Gly  Thr Glu Leu 
    1820                 1825                 1830             


Ser Gln  Arg Leu Val Arg Ser  Gly Phe Ala Gly Thr  Glu Ile Asp 
    1835                 1840                 1845             


Pro Glu  Asn Glu Glu Leu Met  Leu Asn Ile Ser Ser  Arg Leu Gln 
    1850                 1855                 1860             


Ala Ala  Val Glu Lys Leu Leu  Glu Ala Ile Ser Glu  Thr Ser Ser 
    1865                 1870                 1875             


Gln Leu  Glu His Ala Lys Val  Thr Gln Thr Glu Leu  Met Arg Glu 
    1880                 1885                 1890             


Ser Phe  Arg Gln Lys Gln Glu  Ala Thr Glu Ser Leu  Lys Cys Gln 
    1895                 1900                 1905             


Glu Glu  Leu Arg Glu Arg Leu  His Glu Glu Ser Arg  Ala Arg Glu 
    1910                 1915                 1920             


Gln Leu  Ala Val Glu Leu Ser  Lys Ala Glu Gly Val  Ile Asp Gly 
    1925                 1930                 1935             


Tyr Ala  Asp Glu Lys Thr Leu  Phe Glu Arg Gln Ile  Gln Glu Lys 
    1940                 1945                 1950             


Thr Asp  Ile Ile Asp Arg Leu  Glu Gln Glu Leu Leu  Cys Ala Ser 
    1955                 1960                 1965             


Asn Arg  Leu Gln Glu Leu Glu  Ala Glu Gln Gln Gln  Ile Gln Glu 
    1970                 1975                 1980             


Glu Arg  Glu Leu Leu Ser Arg  Gln Lys Glu Ala Met  Lys Ala Glu 
    1985                 1990                 1995             


Ala Gly  Pro Val Glu Gln Gln  Leu Leu Gln Glu Thr  Glu Lys Leu 
    2000                 2005                 2010             


Met Lys  Glu Lys Leu Glu Val  Gln Cys Gln Ala Glu  Lys Val Arg 
    2015                 2020                 2025             


Asp Asp  Leu Gln Lys Gln Val  Lys Ala Leu Glu Ile  Asp Val Glu 
    2030                 2035                 2040             


Glu Gln  Val Ser Arg Phe Ile  Glu Leu Glu Gln Glu  Lys Asn Thr 
    2045                 2050                 2055             


Glu Leu  Met Asp Leu Arg Gln  Gln Asn Gln Ala Leu  Glu Lys Gln 
    2060                 2065                 2070             


Leu Glu  Lys Met Arg Lys Phe  Leu Asp Glu Gln Ala  Ile Asp Arg 
    2075                 2080                 2085             


Glu His  Glu Arg Asp Val Phe  Gln Gln Glu Ile Gln  Lys Leu Glu 
    2090                 2095                 2100             


Gln Gln  Leu Lys Val Val Pro  Arg Phe Gln Pro Ile  Ser Glu His 
    2105                 2110                 2115             


Gln Thr  Arg Glu Val Glu Gln  Leu Ala Asn His Leu  Lys Glu Lys 
    2120                 2125                 2130             


Thr Asp  Lys Cys Ser Glu Leu  Leu Leu Ser Lys Glu  Gln Leu Gln 
    2135                 2140                 2145             


Arg Asp  Ile Gln Glu Arg Asn  Glu Glu Ile Glu Lys  Leu Glu Phe 
    2150                 2155                 2160             


Arg Val  Arg Glu Leu Glu Gln  Ala Leu Leu Val Ser  Ala Asp Thr 
    2165                 2170                 2175             


Phe Gln  Lys Val Glu Asp Arg  Lys His Phe Gly Ala  Val Glu Ala 
    2180                 2185                 2190             


Lys Pro  Glu Leu Ser Leu Glu  Val Gln Leu Gln Ala  Glu Arg Asp 
    2195                 2200                 2205             


Ala Ile  Asp Arg Lys Glu Lys  Glu Ile Thr Asn Leu  Glu Glu Gln 
    2210                 2215                 2220             


Leu Glu  Gln Phe Arg Glu Glu  Leu Glu Asn Lys Asn  Glu Glu Val 
    2225                 2230                 2235             


Gln Gln  Leu His Met Gln Leu  Glu Ile Gln Lys Lys  Glu Ser Thr 
    2240                 2245                 2250             


Thr Arg  Leu Gln Glu Leu Glu  Gln Glu Asn Lys Leu  Phe Lys Asp 
    2255                 2260                 2265             


Asp Met  Glu Lys Leu Gly Leu  Ala Ile Lys Glu Ser  Asp Ala Met 
    2270                 2275                 2280             


Ser Thr  Gln Asp Gln His Val  Leu Phe Gly Lys Phe  Ala Gln Ile 
    2285                 2290                 2295             


Ile Gln  Glu Lys Glu Val Glu  Ile Asp Gln Leu Asn  Glu Gln Val 
    2300                 2305                 2310             


Thr Lys  Leu Gln Gln Gln Leu  Lys Ile Thr Thr Asp  Asn Lys Val 
    2315                 2320                 2325             


Ile Glu  Glu Lys Asn Glu Leu  Ile Arg Asp Leu Glu  Thr Gln Ile 
    2330                 2335                 2340             


Glu Cys  Leu Met Ser Asp Gln  Glu Cys Val Lys Arg  Asn Arg Glu 
    2345                 2350                 2355             


Glu Glu  Ile Glu Gln Leu Asn  Glu Val Ile Glu Lys  Leu Gln Gln 
    2360                 2365                 2370             


Glu Leu  Ala Asn Ile Gly Gln  Lys Thr Ser Met Asn  Ala His Ser 
    2375                 2380                 2385             


Leu Ser  Glu Glu Ala Asp Ser  Leu Lys His Gln Leu  Asp Val Val 
    2390                 2395                 2400             


Ile Ala  Glu Lys Leu Ala Leu  Glu Gln Gln Val Glu  Thr Ala Asn 
    2405                 2410                 2415             


Glu Glu  Met Thr Phe Met Lys  Asn Val Leu Lys Glu  Thr Asn Phe 
    2420                 2425                 2430             


Lys Met  Asn Gln Leu Thr Gln  Glu Leu Phe Ser Leu  Lys Arg Glu 
    2435                 2440                 2445             


Arg Glu  Ser Val Glu Lys Ile  Gln Ser Ile Pro Glu  Asn Ser Val 
    2450                 2455                 2460             


Asn Val  Ala Ile Asp His Leu  Ser Lys Asp Lys Pro  Glu Leu Glu 
    2465                 2470                 2475             


Val Val  Leu Thr Glu Asp Ala  Leu Lys Ser Leu Glu  Asn Gln Thr 
    2480                 2485                 2490             


Tyr Phe  Lys Ser Phe Glu Glu  Asn Gly Lys Gly Ser  Ile Ile Asn 
    2495                 2500                 2505             


Leu Glu  Thr Arg Leu Leu Gln  Leu Glu Ser Thr Val  Ser Ala Lys 
    2510                 2515                 2520             


Asp Leu  Glu Leu Thr Gln Cys  Tyr Lys Gln Ile Lys  Asp Met Gln 
    2525                 2530                 2535             


Glu Gln  Gly Gln Phe Glu Thr  Glu Met Leu Gln Lys  Lys Ile Val 
    2540                 2545                 2550             


Asn Leu  Gln Lys Ile Val Glu  Glu Lys Val Ala Ala  Ala Leu Val 
    2555                 2560                 2565             


Ser Gln  Ile Gln Leu Glu Ala  Val Gln Glu Tyr Ala  Lys Phe Cys 
    2570                 2575                 2580             


Gln Asp  Asn Gln Thr Ile Ser  Ser Glu Pro Glu Arg  Thr Asn Ile 
    2585                 2590                 2595             


Gln Asn  Leu Asn Gln Leu Arg  Glu Asp Glu Leu Gly  Ser Asp Ile 
    2600                 2605                 2610             


Ser Ala  Leu Thr Leu Arg Ile  Ser Glu Leu Glu Ser  Gln Val Val 
    2615                 2620                 2625             


Glu Met  His Thr Ser Leu Ile  Leu Glu Lys Glu Gln  Val Glu Ile 
    2630                 2635                 2640             


Ala Glu  Lys Asn Val Leu Glu  Lys Glu Lys Lys Leu  Leu Glu Leu 
    2645                 2650                 2655             


Gln Lys  Leu Leu Glu Gly Asn  Glu Lys Lys Gln Arg  Glu Lys Glu 
    2660                 2665                 2670             


Lys Lys  Arg Ser Pro Gln Asp  Val Glu Val Leu Lys  Thr Thr Thr 
    2675                 2680                 2685             


Glu Leu  Phe His Ser Asn Glu  Glu Ser Gly Phe Phe  Asn Glu Leu 
    2690                 2695                 2700             


Glu Ala  Leu Arg Ala Glu Ser  Val Ala Thr Lys Ala  Glu Leu Ala 
    2705                 2710                 2715             


Ser Tyr  Lys Glu Lys Ala Glu  Lys Leu Gln Glu Glu  Leu Leu Val 
    2720                 2725                 2730             


Lys Glu  Thr Asn Met Thr Ser  Leu Gln Lys Asp Leu  Ser Gln Val 
    2735                 2740                 2745             


Arg Asp  His Leu Ala Glu Ala  Lys Glu Lys Leu Ser  Ile Leu Glu 
    2750                 2755                 2760             


Lys Glu  Asp Glu Thr Glu Val  Gln Glu Ser Lys Lys  Ala Cys Met 
    2765                 2770                 2775             


Phe Glu  Pro Leu Pro Ile Lys  Leu Ser Lys Ser Ile  Ala Ser Gln 
    2780                 2785                 2790             


Thr Asp  Gly Thr Leu Lys Ile  Ser Ser Ser Asn Gln  Thr Pro Gln 
    2795                 2800                 2805             


Ile Leu  Val Lys Asn Ala Gly  Ile Gln Ile Asn Leu  Gln Ser Glu 
    2810                 2815                 2820             


Cys Ser  Ser Glu Glu Val Thr  Glu Ile Ile Ser Gln  Phe Thr Glu 
    2825                 2830                 2835             


Lys Ile  Glu Lys Met Gln Glu  Leu His Ala Ala Glu  Ile Leu Asp 
    2840                 2845                 2850             


Met Glu  Ser Arg His Ile Ser  Glu Thr Glu Thr Leu  Lys Arg Glu 
    2855                 2860                 2865             


His Tyr  Val Ala Val Gln Leu  Leu Lys Glu Glu Cys  Gly Thr Leu 
    2870                 2875                 2880             


Lys Ala  Val Ile Gln Cys Leu  Arg Ser Lys Glu Val  Phe Gly Phe 
    2885                 2890                 2895             


Tyr Asn  Met Cys Phe Ser Thr  Leu Cys Asp Ser Gly  Ser Asp Trp 
    2900                 2905                 2910             


Gly Gln  Gly Ile Tyr Leu Thr  His Ser Gln Gly Phe  Asp Ile Ala 
    2915                 2920                 2925             


Ser Glu  Gly Arg Gly Glu Glu  Ser Glu Ser Ala Thr  Asp Ser Phe 
    2930                 2935                 2940             


Pro Lys  Lys Ile Lys Gly Leu  Leu Arg Ala Val His  Asn Glu Gly 
    2945                 2950                 2955             


Met Gln  Val Leu Ser Leu Thr  Glu Ser Pro Tyr Ser  Asp Gly Glu 
    2960                 2965                 2970             


Asp His  Ser Ile Gln Gln Val  Ser Glu Pro Trp Leu  Glu Glu Arg 
    2975                 2980                 2985             


Lys Ala  Tyr Ile Asn Thr Ile  Ser Ser Leu Lys Asp  Leu Ile Thr 
    2990                 2995                 3000             


Lys Met  Gln Leu Gln Arg Glu  Ala Glu Val Tyr Asp  Ser Ser Gln 
    3005                 3010                 3015             


Ser His  Glu Ser Phe Ser Asp  Trp Arg Gly Glu Leu  Leu Leu Ala 
    3020                 3025                 3030             


Leu Gln  Gln Val Phe Leu Glu  Glu Arg Ser Val Leu  Leu Ala Ala 
    3035                 3040                 3045             


Phe Arg  Thr Glu Leu Thr Ala  Leu Gly Thr Thr Asp  Ala Val Gly 
    3050                 3055                 3060             


Leu Leu  Asn Cys Leu Glu Gln  Arg Ile Gln Glu Gln  Gly Val Glu 
    3065                 3070                 3075             


Tyr Gln  Ala Ala Met Glu Cys  Leu Gln Lys Ala Asp  Arg Arg Ser 
    3080                 3085                 3090             


Leu Leu  Ser Glu Ile Gln Ala  Leu His Ala Gln Met  Asn Gly Arg 
    3095                 3100                 3105             


Lys Ile  Thr Leu Lys Arg Glu  Gln Glu Ser Glu Lys  Pro Ser Gln 
    3110                 3115                 3120             


Glu Leu  Leu Glu Tyr Asn Ile  Gln Gln Lys Gln Ser  Gln Met Leu 
    3125                 3130                 3135             


Glu Met  Gln Val Glu Leu Ser  Ser Met Lys Asp Arg  Ala Thr Glu 
    3140                 3145                 3150             


Leu Gln  Glu Gln Leu Ser Ser  Glu Lys Met Val Val  Ala Glu Leu 
    3155                 3160                 3165             


Lys Ser  Glu Leu Ala Gln Thr  Lys Leu Glu Leu Glu  Thr Thr Leu 
    3170                 3175                 3180             


Lys Ala  Gln His Lys His Leu  Lys Glu Leu Glu Ala  Phe Arg Leu 
    3185                 3190                 3195             


Glu Val  Lys Asp Lys Thr Asp  Glu Val His Leu Leu  Asn Asp Thr 
    3200                 3205                 3210             


Leu Ala  Ser Glu Gln Lys Lys  Ser Arg Glu Leu Gln  Trp Ala Leu 
    3215                 3220                 3225             


Glu Lys  Glu Lys Ala Lys Leu  Gly Arg Ser Glu Glu  Arg Asp Lys 
    3230                 3235                 3240             


Glu Glu  Leu Glu Asp Leu Lys  Phe Ser Leu Glu Ser  Gln Lys Gln 
    3245                 3250                 3255             


Arg Asn  Leu Gln Leu Asn Leu  Leu Leu Glu Gln Gln  Lys Gln Leu 
    3260                 3265                 3270             


Leu Asn  Glu Ser Gln Gln Lys  Ile Glu Ser Gln Arg  Met Leu Tyr 
    3275                 3280                 3285             


Asp Ala  Gln Leu Ser Glu Glu  Gln Gly Arg Asn Leu  Glu Leu Gln 
    3290                 3295                 3300             


Val Leu  Leu Glu Ser Glu Lys  Val Arg Ile Arg Glu  Met Ser Ser 
    3305                 3310                 3315             


Thr Leu  Asp Arg Glu Arg Glu  Leu His Ala Gln Leu  Gln Ser Ser 
    3320                 3325                 3330             


Asp Gly  Thr Gly Gln Ser Arg  Pro Pro Leu Pro Ser  Glu Asp Leu 
    3335                 3340                 3345             


Leu Lys  Glu Leu Gln Lys Gln  Leu Glu Glu Lys His  Ser Arg Ile 
    3350                 3355                 3360             


Val Glu  Leu Leu Asn Glu Thr  Glu Lys Tyr Lys Leu  Asp Ser Leu 
    3365                 3370                 3375             


Gln Thr  Arg Gln Gln Met Glu  Lys Asp Arg Gln Val  His Arg Lys 
    3380                 3385                 3390             


Thr Leu  Gln Thr Glu Gln Glu  Ala Asn Thr Glu Gly  Gln Lys Lys 
    3395                 3400                 3405             


Met His  Glu Leu Gln Ser Lys  Val Glu Asp Leu Gln  Arg Gln Leu 
    3410                 3415                 3420             


Glu Glu  Lys Arg Gln Gln Val  Tyr Lys Leu Asp Leu  Glu Gly Gln 
    3425                 3430                 3435             


Arg Leu  Gln Gly Ile Met Gln  Glu Phe Gln Lys Gln  Glu Leu Glu 
    3440                 3445                 3450             


Arg Glu  Glu Lys Arg Glu Ser  Arg Arg Ile Leu Tyr  Gln Asn Leu 
    3455                 3460                 3465             


Asn Glu  Pro Thr Thr Trp Ser  Leu Thr Ser Asp Arg  Thr Arg Asn 
    3470                 3475                 3480             


Trp Val  Leu Gln Gln Lys Ile  Glu Gly Glu Thr Lys  Glu Ser Asn 
    3485                 3490                 3495             


Tyr Ala  Lys Leu Ile Glu Met  Asn Gly Gly Gly Thr  Gly Cys Asn 
    3500                 3505                 3510             


His Glu  Leu Glu Met Ile Arg  Gln Lys Leu Gln Cys  Val Ala Ser 
    3515                 3520                 3525             


Lys Leu  Gln Val Leu Pro Gln  Lys Ala Ser Glu Arg  Leu Gln Phe 
    3530                 3535                 3540             


Glu Thr  Ala Asp Asp Glu Asp  Phe Ile Trp Val Gln  Glu Asn Ile 
    3545                 3550                 3555             


Asp Glu  Ile Ile Leu Gln Leu  Gln Lys Leu Thr Gly  Gln Gln Gly 
    3560                 3565                 3570             


Glu Glu  Pro Ser Leu Val Ser  Pro Ser Thr Ser Cys  Gly Ser Leu 
    3575                 3580                 3585             


Thr Glu  Arg Leu Leu Arg Gln  Asn Ala Glu Leu Thr  Gly His Ile 
    3590                 3595                 3600             


Ser Gln  Leu Thr Glu Glu Lys  Asn Asp Leu Arg Asn  Met Val Met 
    3605                 3610                 3615             


Lys Leu  Glu Glu Gln Ile Arg  Trp Tyr Arg Gln Thr  Gly Ala Gly 
    3620                 3625                 3630             


Arg Asp  Asn Ser Ser Arg Phe  Ser Leu Asn Gly Gly  Ala Asn Ile 
    3635                 3640                 3645             


Glu Ala  Ile Ile Ala Ser Glu  Lys Glu Val Trp Asn  Arg Glu Lys 
    3650                 3655                 3660             


Leu Thr  Leu Gln Lys Ser Leu  Lys Arg Ala Glu Ala  Glu Val Tyr 
    3665                 3670                 3675             


Lys Leu  Lys Ala Glu Leu Arg  Asn Asp Ser Leu Leu  Gln Thr Leu 
    3680                 3685                 3690             


Ser Pro  Asp Ser Glu His Val  Thr Leu Lys Arg Ile  Tyr Gly Lys 
    3695                 3700                 3705             


Tyr Leu  Arg Ala Glu Ser Phe  Arg Lys Ala Leu Ile  Tyr Gln Lys 
    3710                 3715                 3720             


Lys Tyr  Leu Leu Leu Leu Leu  Gly Gly Phe Gln Glu  Cys Glu Asp 
    3725                 3730                 3735             


Ala Thr  Leu Ala Leu Leu Ala  Arg Met Gly Gly Gln  Pro Ala Phe 
    3740                 3745                 3750             


Thr Asp  Leu Glu Val Ile Thr  Asn Arg Pro Lys Gly  Phe Thr Arg 
    3755                 3760                 3765             


Phe Arg  Ser Ala Val Arg Val  Ser Ile Ala Ile Ser  Arg Met Lys 
    3770                 3775                 3780             


Phe Leu  Val Arg Arg Trp His  Arg Val Thr Gly Ser  Val Ser Ile 
    3785                 3790                 3795             


Asn Ile  Asn Arg Asp Gly Phe  Gly Leu Asn Gln Gly  Ala Glu Lys 
    3800                 3805                 3810             


Thr Asp  Ser Phe Tyr His Ser  Ser Gly Gly Leu Glu  Leu Tyr Gly 
    3815                 3820                 3825             


Glu Pro  Arg His Thr Thr Tyr  Arg Ser Arg Ser Asp  Leu Asp Tyr 
    3830                 3835                 3840             


Ile Arg  Ser Pro Leu Pro Phe  Gln Asn Arg Tyr Pro  Gly Thr Pro 
    3845                 3850                 3855             


Ala Asp  Phe Asn Pro Gly Ser  Leu Ala Cys Ser Gln  Leu Gln Asn 
    3860                 3865                 3870             


Tyr Asp  Pro Asp Arg Ala Leu  Thr Asp Tyr Ile Thr  Arg Leu Glu 
    3875                 3880                 3885             


Ala Leu  Gln Arg Arg Leu Gly  Thr Ile Gln Ser Gly  Ser Thr Thr 
    3890                 3895                 3900             


Gln Phe  His Ala Gly Met Arg  Arg 
    3905                 3910     


<210>  11
<211>  8442
<212>  DNA
<213>  Homo sapiens

<400>  11
atgaaactta atccacagca agctccctta tatggtgatt gtgttgttac agtgctgctt       60

gctgaagagg acaaagctga agatgatgta gtgttttact tggtattttt gggttccacc      120

ctccgtcact gtacaagtac tcggaaggtc agttctgata cattggagac cattgctcct      180

ggtcatgatt gttgtgaaac agtgaaggtg cagctctgtg cttccaaaga gggccttccc      240

gtgtttgtgg tggctgaaga agactttcat ttcgtccagg atgaagcgta tgatgcagct      300

caattcctag caaccagtgc tggaaatcag caggctttga actttacccg ttttcttgac      360

cagtcaggac ccccatctgg ggatgtgaat tcccttgata agaagttggt gctggcattc      420

aggcacctga agctgcccac ggagtggaat gtattgggga cagatcagag tttgcatgat      480

gctggcccgc gagagacatt gatgcatttt gctgtgcggc tgggactgct gaggttgacg      540

tggttcctgt tgcagaagcc aggtggccgc ggagctctca gtatccacaa ccaggaaggg      600

gcgacgcctg tgagcttggc cttggagcga ggctatcaca agctgcacca gcttctaacc      660

gaggagaatg ctggagaacc agactcctgg agcagtttat cctatgaaat accgtatgga      720

gactgttctg tgaggcatca tcgagagttg gacatctata cattaacctc tgagtctgat      780

tcacatcatg aacacccatt tcctggagac ggttgcactg gaccaatttt taaacttatg      840

aacatccaac agcaactaat gaaaacaaac ctcaagcaga tggacagtct tatgccctta      900

atgatgacag cacaggatcc ttccagtgcc ccagagacag atggccagtt tcttccctgt      960

gcaccggagc ccacggaccc tcagcgactt tcttcttctg aagagactga gagcactcag     1020

tgctgcccag ggagccctgt tgcacagact gaaagtccct gtgatttgtc aagcatagtt     1080

gaggaggaga atacagaccg ttcctgtagg aagaaaaata aaggcgtgga aagaaaaggg     1140

gaagaggtgg agccagcacc tattgtggac tctggaactg tatctgatca agacagctgc     1200

cttcagagct tgcctgattg tggagtaaag ggcacggaag gcctttcgtc ctgtggaaac     1260

agaaatgaag aaactggaac aaaatcttct ggaatgccca cagaccagga gtccctgagc     1320

agtggagatg ctgtgcttca gagagacttg gtcatggagc caggcacagc ccagtattcc     1380

tctggaggtg aactgggagg catttcaaca acaaatgtca gtaccccaga cactgcaggg     1440

gaaatggaac atgggctcat gaacccagat gccactgttt ggaagaatgt gcttcaggga     1500

ggggaaagta caaaggaaag atttgagaac tctaatattg gcacagctgg agcctctgac     1560

gtgcacgtca caagtaagcc tgtggataaa atcagtgttc caaactgtgc ccctgctgcc     1620

agttccctgg atggtaacaa acctgctgag tcttcacttg catttagtaa tgaagaaacc     1680

tccactgaaa aaacagcaga aacggaaact tcacgaagtc gtgaggagag tgctgatgct     1740

ccagtagatc agaattctgt ggtgattcca gctgctgcaa aagacaagat ttcagatgga     1800

ttagaacctt atactctctt agcagcaggc ataggtgagg caatgtcacc ctcagattta     1860

gcccttcttg ggctggaaga agatgtaatg ccacaccaga actcagaaac aaattcatct     1920

catgctcaaa gccaaaaggg caaatcctca cccatttgtt ctacaactgg agacgataaa     1980

ctttgtgcag actctgcatg tcaacagaac acagtgactt ctagtggcga tttggttgca     2040

aaactgtgtg ataacatagt tagcgagtcc gaaagcacca cagcaaggca acccagctca     2100

caagatccac ccgatgcctc ccactgtgaa gacccacagg ctcatacagt cacctctgac     2160

cctgtaaggg atacccagga acgtgcggat ttttgtcctt tcaaagtggt ggataacaaa     2220

ggccaacgaa aagatgtgaa actagataaa cctttaacaa atatgcttga ggtggtttca     2280

catccacatc cagttgtccc taaaatggag aaagaactgg tgccagacca ggcagtaata     2340

tcagacagta ctttctctct ggcaaacagt ccaggcagtg aatcagtaac caaggatgac     2400

gcactttctt ttgtcccctc ccagaaagaa aagggaacag caactcctga actacataca     2460

gctacagatt atagagatgg cccagatgga aattcgaatg agcctgatac gcggccacta     2520

gaagacaggg cagtaggcct gtccacatcc tccactgctg cagagcttca gcacgggatg     2580

gggaatacca gtctcacagg acttggtgga gagcatgagg gtcccgcccc tccagcaatc     2640

ccagaagctc tgaatatcaa ggggaacact gactcttccc tgcaaagtgt gggtaaggcc     2700

actttggctt tagattcagt tttgactgaa gaaggaaaac ttctggtggt ttcagaaagc     2760

tctgcagctc aggaacaaga taaggataaa gcggtgacct gttcctctat taaggaaaat     2820

gctctctctt caggaacttt gcaggaagag cagagaacac cacctcctgg acaagatact     2880

caacaatttc atgaaaaatc aatctcagct gactgtgcca aggacaaagc acttcagcta     2940

agtaattcac cgggtgcatc ctctgccttt cttaaggcag aaactgaaca taacaaggaa     3000

gtggccccac aagtctcact gctgactcaa ggtggggctg cccagagcct ggtgccacca     3060

ggagcaagtc tggccacaga gtcaaggcag gaagccttgg gggcagagca caacagctcc     3120

gctctgttgc catgtctgtt gccagatggg tctgatgggt ccgatgctct taactgcagt     3180

cagccttctc ctctggatgt tggagtgaag aacactcaat cccagggaaa aactagtgcc     3240

tgtgaggtga gtggagatgt gacggtggat gttacagggg ttaatgctct acaaggtatg     3300

gctgagccca gaagagagaa tatatcacac aacacccaag acatcctgat tccaaacgtc     3360

ttgttgagcc aagagaagaa tgccgttcta ggtttgccag tggctctaca ggacaaagct     3420

gtgactgacc cacagggagt tggaacccca gagatgatac ctcttgattg ggagaaaggg     3480

aagctggagg gagcagacca cagctgtacc atgggtgacg ctgaggaagc ccaaatagac     3540

gatgaagcac atcctgtcct actgcagcct gttgccaagg agctccccac agacatggag     3600

ctctcagccc atgatgatgg ggccccagct ggtgtgaggg aagtcatgcg agccccgcct     3660

tcaggcaggg aaaggagcac tccctctcta ccttgcatgg tctctgccca ggacgcacct     3720

ctgcctaagg gggcagactt gatagaggag gctgccagcc gtatagtgga tgctgtcatc     3780

gaacaagtca aggccgctgg agcactgctt actgaggggg aggcctgtca catgtcactg     3840

tccagccctg agttgggtcc tctcactaaa ggactagaga gtgcttttac agaaaaagtg     3900

agtactttcc cacctgggga gagcctacca atgggcagta ctcctgagga agccacgggg     3960

agccttgcag gatgttttgc tggaagggag gagccagaga agatcatttt acctgtccag     4020

gggcctgagc cagcagcaga aatgccagac gtgaaagctg aagatgaagt ggattttaga     4080

gcaagttcaa tttctgaaga agtggctgta gggagcatag ctgctacact gaagatgaag     4140

caaggcccaa tgacccaggc gataaaccga gaaaactggt gtacaataga gccatgccct     4200

gatgcagcat ctcttctggc ttccaagcag agcccagaat gtgagaactt cctggatgtt     4260

ggactgggca gagagtgtac ctcaaaacaa ggtgtactta aaagagaatc tgggagtgat     4320

tctgacctct ttcactcacc cagtgatgac atggacagca tcatcttccc aaagccagag     4380

gaagagcatt tggcctgtga tatcaccgga tccagttcat ccaccgatga cacggcttca     4440

ctggaccgac attcttctca tggcagtgat gtgtctctct cccagatttt aaagccaaac     4500

aggtcaagag atcggcaaag ccttgatgga ttctacagcc atgggatggg agctgagggt     4560

cgagaaagtg agagtgagcc tgctgaccca ggcgacgtgg aggaggagga gatggacagt     4620

atcactgaag tgcctgcaaa ctgctctgtc ctaaggagct ccatgcgctc tctttctccc     4680

ttccggaggc acagctgggg gcctgggaaa aatgcagcca gcgatgcaga aatgaaccac     4740

cggagttcaa tgcgagttct tggggatgtt gtcaggagac ctcccattca taggagaagt     4800

ttcagtctag aaggcttgac aggaggagct ggtgtcggaa acaagccatc ctcatctcta     4860

gaagtaagct ctgcaaatgc cgaagagctc agacacccat tcagtggtga ggaacgggtt     4920

gactctttgg tgtcactttc agaagaggat ctggagtcag accagagaga acataggatg     4980

tttgatcagc agatatgtca cagatctaag cagcagggat ttaattactg tacatcagcc     5040

atttcctctc cattgacaaa atccatctca ttaatgacaa tcagccatcc tggattggac     5100

aattcacggc ccttccacag taccttccac aataccagtg ctaatctgac tgagagtata     5160

acagaagaga actataattt cctgccacat agcccctcca agaaagattc tgaatggaag     5220

agtggaacaa aagtcagtcg tacattcagc tacatcaaga ataaaatgtc tagcagcaag     5280

aagagcaaag aaaaggaaaa agaaaaagat aagattaagg agaaggagaa agattctaaa     5340

gacaaggaga aagataagaa gactgtcaac gggcacactt tcagttccat tcctgttgtg     5400

ggtcccatca gctgtagcca gtgtatgaag cccttcacca acaaagatgc ctatacttgt     5460

gcaaattgca gtgcttttgt ccacaaaggc tgccgagaaa gtctagcctc ctgtgcaaag     5520

gtcaaaatga agcagcccaa agggagcctt caggcacatg acacatcatc actgcccacg     5580

gtcattatga gaaacaagcc ctcacagccc aaggagcgtc ctcggtccgc agtcctcctg     5640

gtggatgaaa ccgctaccac cccaatattt gccaatagac gatcccagca gagtgtctcg     5700

ctctccaaaa gtgtctccat acagaacatt actggagttg gcaatgatga gaacatgtca     5760

aacacctgga aattcctgtc tcattcaaca gactcactaa ataaaatcag caaggtcaat     5820

gagtcaacag aatcacttac tgatgaggga gtaggtacag acatgaatga aggacaacta     5880

ctgggagact ttgagattga gtccaaacag ctggaagcag agtcttggag tcggataata     5940

gacagcaagt ttctaaaaca gcaaaagaaa gatgtggtca aacggcaaga agtaatatat     6000

gagttgatgc agacagagtt tcatcatgtc cgcactctca agatcatgag tggtgtgtac     6060

agccagggga tgatggcgga tctgcttttt gagcagcaga tggtagaaaa gctgttcccc     6120

tgtttggatg agctgatcag tatccatagc caattcttcc agaggattct ggagcggaag     6180

aaggagtctc tggtggataa aagtgaaaag aactttctca tcaagaggat aggggatgtg     6240

cttgtaaatc agttttcagg tgagaatgca gaacgtttaa agaagacata tggcaagttt     6300

tgtgggcaac ataaccagtc tgtaaactac ttcaaagacc tttatgccaa ggataagcgt     6360

tttcaagcct ttgtaaagaa gaagatgagc agttcagttg ttagaaggct tggaattcca     6420

gagtgcatat tgcttgtaac tcagcggatt accaagtacc cagttttatt ccaaagaata     6480

ttgcagtgta ccaaagacaa tgaagtggag caggaagatc tagcacagtc cttgagcctg     6540

gtgaaggatg tgattggagc tgtagacagc aaagtggcaa gttatgaaaa gaaagtgcgt     6600

ctcaatgaga tttatacaaa gacagatagc aagtcaatca tgaggatgaa gagtggtcag     6660

atgtttgcca aggaagattt gaaacggaag aagcttgtac gtgatgggag tgtgtttctg     6720

aagaatgcag caggaaggtt gaaagaggtt caagcagttc ttctcactga cattttagtt     6780

ttccttcaag aaaaagacca gaagtacatc tttgcatcat tggaccagaa gtcaacagtg     6840

atctctttaa agaagctgat tgtgagagaa gtggcacatg aggagaaagg tttattcctg     6900

atcagcatgg ggatgacaga tccagagatg gtagaagtcc atgccagctc caaagaggaa     6960

cgaaacagct ggattcagat cattcaggac acaatcaaca ccctgaacag agatgaagat     7020

gaaggaattc ctagtgagaa tgaggaagaa aagaaaatgt tggacaccag agcccgagaa     7080

ttaaaagaac aacttcacca gaaggaccaa aaaatcctac tcttgttgga agagaaggag     7140

atgattttcc gggacatggc tgagtgcagc acccctctcc cagaggattg ctccccaaca     7200

catagcccta gagttctctt ccgctccaac acagaagagg ctctcaaagg aggaccttta     7260

atgaaaagtg caataaatga ggtggagatc cttcagggtt tggtgagtgg aaatctggga     7320

ggcacacttg ggccgactgt cagcagcccc attgagcaag atgtggtcgg tcccgtttcc     7380

ctgccccgga gagcagagac ctttggagga tttgacagcc atcagatgaa tgcttcaaaa     7440

ggaggcgaga aggaagaggg agatgatggc caagatctta ggagaacgga atcagatagt     7500

ggcctaaaaa agggtggaaa tgctaacctg gtatttatgc ttaaaagaaa cagtgagcag     7560

gttgtccaga gcgttgttca tctctacgag ctcctcagcg ctctgcaggg tgtggtgctg     7620

cagcaggaca gctacattga ggaccagaaa ctggtgctga gcgagagggc gctcactcgc     7680

agcttgtccc gcccgagctc cctcattgag caggagaagc agcgcagcct ggagaagcag     7740

cgccaggacc tggccaacct gcagaagcag caggcccagt acctcgagga gaagcgcagg     7800

cgcgagcgtg agtgggaagc tcgtgagagg gagctgcggg agcgggaggc cctcctggcc     7860

cagcgcgagg aggaggtgca gcaggggcag caggacctgg aaaaggagcg ggaggagctc     7920

cagcagaaga agggcacata ccagtatgac ctggagcgac tgcgtgctgc ccagaaacag     7980

cttgagaggg aacaggagca gctgcgccgg gaggcagagc ggctcagcca gcggcagaca     8040

gaacgggacc tgtgtcaggt ttcccatcca cataccaagc tgatgaggat cccatcgttc     8100

ttccccagtc ctgaggagcc cccctcgcca tctgcacctt ccatagccaa atcagggtca     8160

ttggactcag aactttcagt gtccccaaaa aggaacagca tctctcggac acacaaagat     8220

aaggggcctt ttcacatact gagttcaacc agccagacaa acaaaggacc agaagggcag     8280

agccaggccc ctgcgtccac ctctgcctct acccgcctgt ttgggttaac aaagccaaag     8340

gaaaagaagg agaaaaaaaa gaagaacaaa accagccgct ctcagcccgg tgatggtccc     8400

gcgtcagaag tatcagcaga gggtgaagag atcttctgct ga                        8442


<210>  12
<211>  2813
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Lys Leu Asn Pro Gln Gln Ala Pro Leu Tyr Gly Asp Cys Val Val 
1               5                   10                  15      


Thr Val Leu Leu Ala Glu Glu Asp Lys Ala Glu Asp Asp Val Val Phe 
            20                  25                  30          


Tyr Leu Val Phe Leu Gly Ser Thr Leu Arg His Cys Thr Ser Thr Arg 
        35                  40                  45              


Lys Val Ser Ser Asp Thr Leu Glu Thr Ile Ala Pro Gly His Asp Cys 
    50                  55                  60                  


Cys Glu Thr Val Lys Val Gln Leu Cys Ala Ser Lys Glu Gly Leu Pro 
65                  70                  75                  80  


Val Phe Val Val Ala Glu Glu Asp Phe His Phe Val Gln Asp Glu Ala 
                85                  90                  95      


Tyr Asp Ala Ala Gln Phe Leu Ala Thr Ser Ala Gly Asn Gln Gln Ala 
            100                 105                 110         


Leu Asn Phe Thr Arg Phe Leu Asp Gln Ser Gly Pro Pro Ser Gly Asp 
        115                 120                 125             


Val Asn Ser Leu Asp Lys Lys Leu Val Leu Ala Phe Arg His Leu Lys 
    130                 135                 140                 


Leu Pro Thr Glu Trp Asn Val Leu Gly Thr Asp Gln Ser Leu His Asp 
145                 150                 155                 160 


Ala Gly Pro Arg Glu Thr Leu Met His Phe Ala Val Arg Leu Gly Leu 
                165                 170                 175     


Leu Arg Leu Thr Trp Phe Leu Leu Gln Lys Pro Gly Gly Arg Gly Ala 
            180                 185                 190         


Leu Ser Ile His Asn Gln Glu Gly Ala Thr Pro Val Ser Leu Ala Leu 
        195                 200                 205             


Glu Arg Gly Tyr His Lys Leu His Gln Leu Leu Thr Glu Glu Asn Ala 
    210                 215                 220                 


Gly Glu Pro Asp Ser Trp Ser Ser Leu Ser Tyr Glu Ile Pro Tyr Gly 
225                 230                 235                 240 


Asp Cys Ser Val Arg His His Arg Glu Leu Asp Ile Tyr Thr Leu Thr 
                245                 250                 255     


Ser Glu Ser Asp Ser His His Glu His Pro Phe Pro Gly Asp Gly Cys 
            260                 265                 270         


Thr Gly Pro Ile Phe Lys Leu Met Asn Ile Gln Gln Gln Leu Met Lys 
        275                 280                 285             


Thr Asn Leu Lys Gln Met Asp Ser Leu Met Pro Leu Met Met Thr Ala 
    290                 295                 300                 


Gln Asp Pro Ser Ser Ala Pro Glu Thr Asp Gly Gln Phe Leu Pro Cys 
305                 310                 315                 320 


Ala Pro Glu Pro Thr Asp Pro Gln Arg Leu Ser Ser Ser Glu Glu Thr 
                325                 330                 335     


Glu Ser Thr Gln Cys Cys Pro Gly Ser Pro Val Ala Gln Thr Glu Ser 
            340                 345                 350         


Pro Cys Asp Leu Ser Ser Ile Val Glu Glu Glu Asn Thr Asp Arg Ser 
        355                 360                 365             


Cys Arg Lys Lys Asn Lys Gly Val Glu Arg Lys Gly Glu Glu Val Glu 
    370                 375                 380                 


Pro Ala Pro Ile Val Asp Ser Gly Thr Val Ser Asp Gln Asp Ser Cys 
385                 390                 395                 400 


Leu Gln Ser Leu Pro Asp Cys Gly Val Lys Gly Thr Glu Gly Leu Ser 
                405                 410                 415     


Ser Cys Gly Asn Arg Asn Glu Glu Thr Gly Thr Lys Ser Ser Gly Met 
            420                 425                 430         


Pro Thr Asp Gln Glu Ser Leu Ser Ser Gly Asp Ala Val Leu Gln Arg 
        435                 440                 445             


Asp Leu Val Met Glu Pro Gly Thr Ala Gln Tyr Ser Ser Gly Gly Glu 
    450                 455                 460                 


Leu Gly Gly Ile Ser Thr Thr Asn Val Ser Thr Pro Asp Thr Ala Gly 
465                 470                 475                 480 


Glu Met Glu His Gly Leu Met Asn Pro Asp Ala Thr Val Trp Lys Asn 
                485                 490                 495     


Val Leu Gln Gly Gly Glu Ser Thr Lys Glu Arg Phe Glu Asn Ser Asn 
            500                 505                 510         


Ile Gly Thr Ala Gly Ala Ser Asp Val His Val Thr Ser Lys Pro Val 
        515                 520                 525             


Asp Lys Ile Ser Val Pro Asn Cys Ala Pro Ala Ala Ser Ser Leu Asp 
    530                 535                 540                 


Gly Asn Lys Pro Ala Glu Ser Ser Leu Ala Phe Ser Asn Glu Glu Thr 
545                 550                 555                 560 


Ser Thr Glu Lys Thr Ala Glu Thr Glu Thr Ser Arg Ser Arg Glu Glu 
                565                 570                 575     


Ser Ala Asp Ala Pro Val Asp Gln Asn Ser Val Val Ile Pro Ala Ala 
            580                 585                 590         


Ala Lys Asp Lys Ile Ser Asp Gly Leu Glu Pro Tyr Thr Leu Leu Ala 
        595                 600                 605             


Ala Gly Ile Gly Glu Ala Met Ser Pro Ser Asp Leu Ala Leu Leu Gly 
    610                 615                 620                 


Leu Glu Glu Asp Val Met Pro His Gln Asn Ser Glu Thr Asn Ser Ser 
625                 630                 635                 640 


His Ala Gln Ser Gln Lys Gly Lys Ser Ser Pro Ile Cys Ser Thr Thr 
                645                 650                 655     


Gly Asp Asp Lys Leu Cys Ala Asp Ser Ala Cys Gln Gln Asn Thr Val 
            660                 665                 670         


Thr Ser Ser Gly Asp Leu Val Ala Lys Leu Cys Asp Asn Ile Val Ser 
        675                 680                 685             


Glu Ser Glu Ser Thr Thr Ala Arg Gln Pro Ser Ser Gln Asp Pro Pro 
    690                 695                 700                 


Asp Ala Ser His Cys Glu Asp Pro Gln Ala His Thr Val Thr Ser Asp 
705                 710                 715                 720 


Pro Val Arg Asp Thr Gln Glu Arg Ala Asp Phe Cys Pro Phe Lys Val 
                725                 730                 735     


Val Asp Asn Lys Gly Gln Arg Lys Asp Val Lys Leu Asp Lys Pro Leu 
            740                 745                 750         


Thr Asn Met Leu Glu Val Val Ser His Pro His Pro Val Val Pro Lys 
        755                 760                 765             


Met Glu Lys Glu Leu Val Pro Asp Gln Ala Val Ile Ser Asp Ser Thr 
    770                 775                 780                 


Phe Ser Leu Ala Asn Ser Pro Gly Ser Glu Ser Val Thr Lys Asp Asp 
785                 790                 795                 800 


Ala Leu Ser Phe Val Pro Ser Gln Lys Glu Lys Gly Thr Ala Thr Pro 
                805                 810                 815     


Glu Leu His Thr Ala Thr Asp Tyr Arg Asp Gly Pro Asp Gly Asn Ser 
            820                 825                 830         


Asn Glu Pro Asp Thr Arg Pro Leu Glu Asp Arg Ala Val Gly Leu Ser 
        835                 840                 845             


Thr Ser Ser Thr Ala Ala Glu Leu Gln His Gly Met Gly Asn Thr Ser 
    850                 855                 860                 


Leu Thr Gly Leu Gly Gly Glu His Glu Gly Pro Ala Pro Pro Ala Ile 
865                 870                 875                 880 


Pro Glu Ala Leu Asn Ile Lys Gly Asn Thr Asp Ser Ser Leu Gln Ser 
                885                 890                 895     


Val Gly Lys Ala Thr Leu Ala Leu Asp Ser Val Leu Thr Glu Glu Gly 
            900                 905                 910         


Lys Leu Leu Val Val Ser Glu Ser Ser Ala Ala Gln Glu Gln Asp Lys 
        915                 920                 925             


Asp Lys Ala Val Thr Cys Ser Ser Ile Lys Glu Asn Ala Leu Ser Ser 
    930                 935                 940                 


Gly Thr Leu Gln Glu Glu Gln Arg Thr Pro Pro Pro Gly Gln Asp Thr 
945                 950                 955                 960 


Gln Gln Phe His Glu Lys Ser Ile Ser Ala Asp Cys Ala Lys Asp Lys 
                965                 970                 975     


Ala Leu Gln Leu Ser Asn Ser Pro Gly Ala Ser Ser Ala Phe Leu Lys 
            980                 985                 990         


Ala Glu Thr Glu His Asn Lys Glu  Val Ala Pro Gln Val  Ser Leu Leu 
        995                 1000                 1005             


Thr Gln  Gly Gly Ala Ala Gln  Ser Leu Val Pro Pro  Gly Ala Ser 
    1010                 1015                 1020             


Leu Ala  Thr Glu Ser Arg Gln  Glu Ala Leu Gly Ala  Glu His Asn 
    1025                 1030                 1035             


Ser Ser  Ala Leu Leu Pro Cys  Leu Leu Pro Asp Gly  Ser Asp Gly 
    1040                 1045                 1050             


Ser Asp  Ala Leu Asn Cys Ser  Gln Pro Ser Pro Leu  Asp Val Gly 
    1055                 1060                 1065             


Val Lys  Asn Thr Gln Ser Gln  Gly Lys Thr Ser Ala  Cys Glu Val 
    1070                 1075                 1080             


Ser Gly  Asp Val Thr Val Asp  Val Thr Gly Val Asn  Ala Leu Gln 
    1085                 1090                 1095             


Gly Met  Ala Glu Pro Arg Arg  Glu Asn Ile Ser His  Asn Thr Gln 
    1100                 1105                 1110             


Asp Ile  Leu Ile Pro Asn Val  Leu Leu Ser Gln Glu  Lys Asn Ala 
    1115                 1120                 1125             


Val Leu  Gly Leu Pro Val Ala  Leu Gln Asp Lys Ala  Val Thr Asp 
    1130                 1135                 1140             


Pro Gln  Gly Val Gly Thr Pro  Glu Met Ile Pro Leu  Asp Trp Glu 
    1145                 1150                 1155             


Lys Gly  Lys Leu Glu Gly Ala  Asp His Ser Cys Thr  Met Gly Asp 
    1160                 1165                 1170             


Ala Glu  Glu Ala Gln Ile Asp  Asp Glu Ala His Pro  Val Leu Leu 
    1175                 1180                 1185             


Gln Pro  Val Ala Lys Glu Leu  Pro Thr Asp Met Glu  Leu Ser Ala 
    1190                 1195                 1200             


His Asp  Asp Gly Ala Pro Ala  Gly Val Arg Glu Val  Met Arg Ala 
    1205                 1210                 1215             


Pro Pro  Ser Gly Arg Glu Arg  Ser Thr Pro Ser Leu  Pro Cys Met 
    1220                 1225                 1230             


Val Ser  Ala Gln Asp Ala Pro  Leu Pro Lys Gly Ala  Asp Leu Ile 
    1235                 1240                 1245             


Glu Glu  Ala Ala Ser Arg Ile  Val Asp Ala Val Ile  Glu Gln Val 
    1250                 1255                 1260             


Lys Ala  Ala Gly Ala Leu Leu  Thr Glu Gly Glu Ala  Cys His Met 
    1265                 1270                 1275             


Ser Leu  Ser Ser Pro Glu Leu  Gly Pro Leu Thr Lys  Gly Leu Glu 
    1280                 1285                 1290             


Ser Ala  Phe Thr Glu Lys Val  Ser Thr Phe Pro Pro  Gly Glu Ser 
    1295                 1300                 1305             


Leu Pro  Met Gly Ser Thr Pro  Glu Glu Ala Thr Gly  Ser Leu Ala 
    1310                 1315                 1320             


Gly Cys  Phe Ala Gly Arg Glu  Glu Pro Glu Lys Ile  Ile Leu Pro 
    1325                 1330                 1335             


Val Gln  Gly Pro Glu Pro Ala  Ala Glu Met Pro Asp  Val Lys Ala 
    1340                 1345                 1350             


Glu Asp  Glu Val Asp Phe Arg  Ala Ser Ser Ile Ser  Glu Glu Val 
    1355                 1360                 1365             


Ala Val  Gly Ser Ile Ala Ala  Thr Leu Lys Met Lys  Gln Gly Pro 
    1370                 1375                 1380             


Met Thr  Gln Ala Ile Asn Arg  Glu Asn Trp Cys Thr  Ile Glu Pro 
    1385                 1390                 1395             


Cys Pro  Asp Ala Ala Ser Leu  Leu Ala Ser Lys Gln  Ser Pro Glu 
    1400                 1405                 1410             


Cys Glu  Asn Phe Leu Asp Val  Gly Leu Gly Arg Glu  Cys Thr Ser 
    1415                 1420                 1425             


Lys Gln  Gly Val Leu Lys Arg  Glu Ser Gly Ser Asp  Ser Asp Leu 
    1430                 1435                 1440             


Phe His  Ser Pro Ser Asp Asp  Met Asp Ser Ile Ile  Phe Pro Lys 
    1445                 1450                 1455             


Pro Glu  Glu Glu His Leu Ala  Cys Asp Ile Thr Gly  Ser Ser Ser 
    1460                 1465                 1470             


Ser Thr  Asp Asp Thr Ala Ser  Leu Asp Arg His Ser  Ser His Gly 
    1475                 1480                 1485             


Ser Asp  Val Ser Leu Ser Gln  Ile Leu Lys Pro Asn  Arg Ser Arg 
    1490                 1495                 1500             


Asp Arg  Gln Ser Leu Asp Gly  Phe Tyr Ser His Gly  Met Gly Ala 
    1505                 1510                 1515             


Glu Gly  Arg Glu Ser Glu Ser  Glu Pro Ala Asp Pro  Gly Asp Val 
    1520                 1525                 1530             


Glu Glu  Glu Glu Met Asp Ser  Ile Thr Glu Val Pro  Ala Asn Cys 
    1535                 1540                 1545             


Ser Val  Leu Arg Ser Ser Met  Arg Ser Leu Ser Pro  Phe Arg Arg 
    1550                 1555                 1560             


His Ser  Trp Gly Pro Gly Lys  Asn Ala Ala Ser Asp  Ala Glu Met 
    1565                 1570                 1575             


Asn His  Arg Ser Ser Met Arg  Val Leu Gly Asp Val  Val Arg Arg 
    1580                 1585                 1590             


Pro Pro  Ile His Arg Arg Ser  Phe Ser Leu Glu Gly  Leu Thr Gly 
    1595                 1600                 1605             


Gly Ala  Gly Val Gly Asn Lys  Pro Ser Ser Ser Leu  Glu Val Ser 
    1610                 1615                 1620             


Ser Ala  Asn Ala Glu Glu Leu  Arg His Pro Phe Ser  Gly Glu Glu 
    1625                 1630                 1635             


Arg Val  Asp Ser Leu Val Ser  Leu Ser Glu Glu Asp  Leu Glu Ser 
    1640                 1645                 1650             


Asp Gln  Arg Glu His Arg Met  Phe Asp Gln Gln Ile  Cys His Arg 
    1655                 1660                 1665             


Ser Lys  Gln Gln Gly Phe Asn  Tyr Cys Thr Ser Ala  Ile Ser Ser 
    1670                 1675                 1680             


Pro Leu  Thr Lys Ser Ile Ser  Leu Met Thr Ile Ser  His Pro Gly 
    1685                 1690                 1695             


Leu Asp  Asn Ser Arg Pro Phe  His Ser Thr Phe His  Asn Thr Ser 
    1700                 1705                 1710             


Ala Asn  Leu Thr Glu Ser Ile  Thr Glu Glu Asn Tyr  Asn Phe Leu 
    1715                 1720                 1725             


Pro His  Ser Pro Ser Lys Lys  Asp Ser Glu Trp Lys  Ser Gly Thr 
    1730                 1735                 1740             


Lys Val  Ser Arg Thr Phe Ser  Tyr Ile Lys Asn Lys  Met Ser Ser 
    1745                 1750                 1755             


Ser Lys  Lys Ser Lys Glu Lys  Glu Lys Glu Lys Asp  Lys Ile Lys 
    1760                 1765                 1770             


Glu Lys  Glu Lys Asp Ser Lys  Asp Lys Glu Lys Asp  Lys Lys Thr 
    1775                 1780                 1785             


Val Asn  Gly His Thr Phe Ser  Ser Ile Pro Val Val  Gly Pro Ile 
    1790                 1795                 1800             


Ser Cys  Ser Gln Cys Met Lys  Pro Phe Thr Asn Lys  Asp Ala Tyr 
    1805                 1810                 1815             


Thr Cys  Ala Asn Cys Ser Ala  Phe Val His Lys Gly  Cys Arg Glu 
    1820                 1825                 1830             


Ser Leu  Ala Ser Cys Ala Lys  Val Lys Met Lys Gln  Pro Lys Gly 
    1835                 1840                 1845             


Ser Leu  Gln Ala His Asp Thr  Ser Ser Leu Pro Thr  Val Ile Met 
    1850                 1855                 1860             


Arg Asn  Lys Pro Ser Gln Pro  Lys Glu Arg Pro Arg  Ser Ala Val 
    1865                 1870                 1875             


Leu Leu  Val Asp Glu Thr Ala  Thr Thr Pro Ile Phe  Ala Asn Arg 
    1880                 1885                 1890             


Arg Ser  Gln Gln Ser Val Ser  Leu Ser Lys Ser Val  Ser Ile Gln 
    1895                 1900                 1905             


Asn Ile  Thr Gly Val Gly Asn  Asp Glu Asn Met Ser  Asn Thr Trp 
    1910                 1915                 1920             


Lys Phe  Leu Ser His Ser Thr  Asp Ser Leu Asn Lys  Ile Ser Lys 
    1925                 1930                 1935             


Val Asn  Glu Ser Thr Glu Ser  Leu Thr Asp Glu Gly  Val Gly Thr 
    1940                 1945                 1950             


Asp Met  Asn Glu Gly Gln Leu  Leu Gly Asp Phe Glu  Ile Glu Ser 
    1955                 1960                 1965             


Lys Gln  Leu Glu Ala Glu Ser  Trp Ser Arg Ile Ile  Asp Ser Lys 
    1970                 1975                 1980             


Phe Leu  Lys Gln Gln Lys Lys  Asp Val Val Lys Arg  Gln Glu Val 
    1985                 1990                 1995             


Ile Tyr  Glu Leu Met Gln Thr  Glu Phe His His Val  Arg Thr Leu 
    2000                 2005                 2010             


Lys Ile  Met Ser Gly Val Tyr  Ser Gln Gly Met Met  Ala Asp Leu 
    2015                 2020                 2025             


Leu Phe  Glu Gln Gln Met Val  Glu Lys Leu Phe Pro  Cys Leu Asp 
    2030                 2035                 2040             


Glu Leu  Ile Ser Ile His Ser  Gln Phe Phe Gln Arg  Ile Leu Glu 
    2045                 2050                 2055             


Arg Lys  Lys Glu Ser Leu Val  Asp Lys Ser Glu Lys  Asn Phe Leu 
    2060                 2065                 2070             


Ile Lys  Arg Ile Gly Asp Val  Leu Val Asn Gln Phe  Ser Gly Glu 
    2075                 2080                 2085             


Asn Ala  Glu Arg Leu Lys Lys  Thr Tyr Gly Lys Phe  Cys Gly Gln 
    2090                 2095                 2100             


His Asn  Gln Ser Val Asn Tyr  Phe Lys Asp Leu Tyr  Ala Lys Asp 
    2105                 2110                 2115             


Lys Arg  Phe Gln Ala Phe Val  Lys Lys Lys Met Ser  Ser Ser Val 
    2120                 2125                 2130             


Val Arg  Arg Leu Gly Ile Pro  Glu Cys Ile Leu Leu  Val Thr Gln 
    2135                 2140                 2145             


Arg Ile  Thr Lys Tyr Pro Val  Leu Phe Gln Arg Ile  Leu Gln Cys 
    2150                 2155                 2160             


Thr Lys  Asp Asn Glu Val Glu  Gln Glu Asp Leu Ala  Gln Ser Leu 
    2165                 2170                 2175             


Ser Leu  Val Lys Asp Val Ile  Gly Ala Val Asp Ser  Lys Val Ala 
    2180                 2185                 2190             


Ser Tyr  Glu Lys Lys Val Arg  Leu Asn Glu Ile Tyr  Thr Lys Thr 
    2195                 2200                 2205             


Asp Ser  Lys Ser Ile Met Arg  Met Lys Ser Gly Gln  Met Phe Ala 
    2210                 2215                 2220             


Lys Glu  Asp Leu Lys Arg Lys  Lys Leu Val Arg Asp  Gly Ser Val 
    2225                 2230                 2235             


Phe Leu  Lys Asn Ala Ala Gly  Arg Leu Lys Glu Val  Gln Ala Val 
    2240                 2245                 2250             


Leu Leu  Thr Asp Ile Leu Val  Phe Leu Gln Glu Lys  Asp Gln Lys 
    2255                 2260                 2265             


Tyr Ile  Phe Ala Ser Leu Asp  Gln Lys Ser Thr Val  Ile Ser Leu 
    2270                 2275                 2280             


Lys Lys  Leu Ile Val Arg Glu  Val Ala His Glu Glu  Lys Gly Leu 
    2285                 2290                 2295             


Phe Leu  Ile Ser Met Gly Met  Thr Asp Pro Glu Met  Val Glu Val 
    2300                 2305                 2310             


His Ala  Ser Ser Lys Glu Glu  Arg Asn Ser Trp Ile  Gln Ile Ile 
    2315                 2320                 2325             


Gln Asp  Thr Ile Asn Thr Leu  Asn Arg Asp Glu Asp  Glu Gly Ile 
    2330                 2335                 2340             


Pro Ser  Glu Asn Glu Glu Glu  Lys Lys Met Leu Asp  Thr Arg Ala 
    2345                 2350                 2355             


Arg Glu  Leu Lys Glu Gln Leu  His Gln Lys Asp Gln  Lys Ile Leu 
    2360                 2365                 2370             


Leu Leu  Leu Glu Glu Lys Glu  Met Ile Phe Arg Asp  Met Ala Glu 
    2375                 2380                 2385             


Cys Ser  Thr Pro Leu Pro Glu  Asp Cys Ser Pro Thr  His Ser Pro 
    2390                 2395                 2400             


Arg Val  Leu Phe Arg Ser Asn  Thr Glu Glu Ala Leu  Lys Gly Gly 
    2405                 2410                 2415             


Pro Leu  Met Lys Ser Ala Ile  Asn Glu Val Glu Ile  Leu Gln Gly 
    2420                 2425                 2430             


Leu Val  Ser Gly Asn Leu Gly  Gly Thr Leu Gly Pro  Thr Val Ser 
    2435                 2440                 2445             


Ser Pro  Ile Glu Gln Asp Val  Val Gly Pro Val Ser  Leu Pro Arg 
    2450                 2455                 2460             


Arg Ala  Glu Thr Phe Gly Gly  Phe Asp Ser His Gln  Met Asn Ala 
    2465                 2470                 2475             


Ser Lys  Gly Gly Glu Lys Glu  Glu Gly Asp Asp Gly  Gln Asp Leu 
    2480                 2485                 2490             


Arg Arg  Thr Glu Ser Asp Ser  Gly Leu Lys Lys Gly  Gly Asn Ala 
    2495                 2500                 2505             


Asn Leu  Val Phe Met Leu Lys  Arg Asn Ser Glu Gln  Val Val Gln 
    2510                 2515                 2520             


Ser Val  Val His Leu Tyr Glu  Leu Leu Ser Ala Leu  Gln Gly Val 
    2525                 2530                 2535             


Val Leu  Gln Gln Asp Ser Tyr  Ile Glu Asp Gln Lys  Leu Val Leu 
    2540                 2545                 2550             


Ser Glu  Arg Ala Leu Thr Arg  Ser Leu Ser Arg Pro  Ser Ser Leu 
    2555                 2560                 2565             


Ile Glu  Gln Glu Lys Gln Arg  Ser Leu Glu Lys Gln  Arg Gln Asp 
    2570                 2575                 2580             


Leu Ala  Asn Leu Gln Lys Gln  Gln Ala Gln Tyr Leu  Glu Glu Lys 
    2585                 2590                 2595             


Arg Arg  Arg Glu Arg Glu Trp  Glu Ala Arg Glu Arg  Glu Leu Arg 
    2600                 2605                 2610             


Glu Arg  Glu Ala Leu Leu Ala  Gln Arg Glu Glu Glu  Val Gln Gln 
    2615                 2620                 2625             


Gly Gln  Gln Asp Leu Glu Lys  Glu Arg Glu Glu Leu  Gln Gln Lys 
    2630                 2635                 2640             


Lys Gly  Thr Tyr Gln Tyr Asp  Leu Glu Arg Leu Arg  Ala Ala Gln 
    2645                 2650                 2655             


Lys Gln  Leu Glu Arg Glu Gln  Glu Gln Leu Arg Arg  Glu Ala Glu 
    2660                 2665                 2670             


Arg Leu  Ser Gln Arg Gln Thr  Glu Arg Asp Leu Cys  Gln Val Ser 
    2675                 2680                 2685             


His Pro  His Thr Lys Leu Met  Arg Ile Pro Ser Phe  Phe Pro Ser 
    2690                 2695                 2700             


Pro Glu  Glu Pro Pro Ser Pro  Ser Ala Pro Ser Ile  Ala Lys Ser 
    2705                 2710                 2715             


Gly Ser  Leu Asp Ser Glu Leu  Ser Val Ser Pro Lys  Arg Asn Ser 
    2720                 2725                 2730             


Ile Ser  Arg Thr His Lys Asp  Lys Gly Pro Phe His  Ile Leu Ser 
    2735                 2740                 2745             


Ser Thr  Ser Gln Thr Asn Lys  Gly Pro Glu Gly Gln  Ser Gln Ala 
    2750                 2755                 2760             


Pro Ala  Ser Thr Ser Ala Ser  Thr Arg Leu Phe Gly  Leu Thr Lys 
    2765                 2770                 2775             


Pro Lys  Glu Lys Lys Glu Lys  Lys Lys Lys Asn Lys  Thr Ser Arg 
    2780                 2785                 2790             


Ser Gln  Pro Gly Asp Gly Pro  Ala Ser Glu Val Ser  Ala Glu Gly 
    2795                 2800                 2805             


Glu Glu  Ile Phe Cys 
    2810             


<210>  13
<211>  1782
<212>  DNA
<213>  Homo sapiens

<400>  13
atgggatccg gctcctccag ctaccggccc aaggccatct acctggacat cgatggacgc       60

attcagaagg taatcttcag caagtactgc aactccagcg acatcatgga cctgttctgc      120

atcgccaccg gcctgcctcg gaacacgacc atctccctgc tgaccaccga cgacgccatg      180

gtctccatcg accccaccat gcccgcgaat tcagaacgca ctccgtacaa agtgagacct      240

gtggccatca agcaactctc cgctggtgtc gaggacaaga gaaccacaag ccgtggccag      300

tctgctgaga gaccactgag ggacagacgg gttgtgggcc tggagcagcc ccggagggaa      360

ggagcatttg aaagtggaca ggtagagccc aggcccagag agccccaggg ctgctaccag      420

gaaggccagc gcatccctcc agagagagaa gaattaatcc agagcgtgct ggcgcaggtt      480

gcagagcagt tctcaagagc attcaaaatc aatgaactga aagctgaagt tgcaaatcac      540

ttggctgtcc tagagaaacg cgtggaattg gaaggactaa aagtggtgga gattgagaaa      600

tgcaagagtg acattaagaa gatgagggag gagctggcgg ccagaagcag caggaccaac      660

tgcccctgta agtacagttt tttggataac cacaagaagt tgactcctcg acgcgatgtt      720

cccacttacc ccaagtacct gctctctcca gagaccatcg aggccctgcg gaagccgacc      780

tttgacgtct ggctttggga gcccaatgag atgctgagct gcctggagca catgtaccac      840

gacctcgggc tggtcaggga cttcagcatc aaccctgtca ccctcaggag gtggctgttc      900

tgcgtccacg acaactacag aaacaacccc ttccacaact tccggcactg cttctgcgtg      960

gcccagatga tgtacagcat ggtctggctc tgcagtctcc aggagaagtt ctcacaaacg     1020

gatatcctga tcctaatgac agcggccatc tgccacgatc tggaccatcc cggctacaac     1080

aacacgtacc agatcaatgc ccgcacagag ctggcggtcc gctacaatga catctcaccg     1140

ctggagaacc accactgcgc cgtggccttc cagatcctcg ccgagcctga gtgcaacatc     1200

ttctccaaca tcccacctga tgggttcaag cagatccgac agggaatgat cacattaatc     1260

ttggccactg acatggcaag acatgcagaa attatggatt ctttcaaaga gaaaatggag     1320

aattttgact acagcaacga ggagcacatg accctgctga agatgatttt gataaaatgc     1380

tgtgatatct ctaacgaggt ccgtccaatg gaagtcgcag agccttgggt ggactgttta     1440

ttagaggaat attttatgca gagcgaccgt gagaagtcag aaggccttcc tgtggcaccg     1500

ttcatggacc gagacaaagt gaccaaggcc acagcccaga ttgggttcat caagtttgtc     1560

ctgatcccaa tgtttgaaac agtgaccaag ctcttcccca tggttgagga gatcatgctg     1620

cagccacttt gggaatcccg agatcgctac gaggagctga agcggataga tgacgccatg     1680

aaagagttac agaagaagac tgacagcttg acgtctgggg ccaccgagaa gtccagagag     1740

agaagcagag atgtgaaaaa cagtgaagga gactgtgcct ga                        1782


<210>  14
<211>  593
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Gly Ser Gly Ser Ser Ser Tyr Arg Pro Lys Ala Ile Tyr Leu Asp 
1               5                   10                  15      


Ile Asp Gly Arg Ile Gln Lys Val Ile Phe Ser Lys Tyr Cys Asn Ser 
            20                  25                  30          


Ser Asp Ile Met Asp Leu Phe Cys Ile Ala Thr Gly Leu Pro Arg Asn 
        35                  40                  45              


Thr Thr Ile Ser Leu Leu Thr Thr Asp Asp Ala Met Val Ser Ile Asp 
    50                  55                  60                  


Pro Thr Met Pro Ala Asn Ser Glu Arg Thr Pro Tyr Lys Val Arg Pro 
65                  70                  75                  80  


Val Ala Ile Lys Gln Leu Ser Ala Gly Val Glu Asp Lys Arg Thr Thr 
                85                  90                  95      


Ser Arg Gly Gln Ser Ala Glu Arg Pro Leu Arg Asp Arg Arg Val Val 
            100                 105                 110         


Gly Leu Glu Gln Pro Arg Arg Glu Gly Ala Phe Glu Ser Gly Gln Val 
        115                 120                 125             


Glu Pro Arg Pro Arg Glu Pro Gln Gly Cys Tyr Gln Glu Gly Gln Arg 
    130                 135                 140                 


Ile Pro Pro Glu Arg Glu Glu Leu Ile Gln Ser Val Leu Ala Gln Val 
145                 150                 155                 160 


Ala Glu Gln Phe Ser Arg Ala Phe Lys Ile Asn Glu Leu Lys Ala Glu 
                165                 170                 175     


Val Ala Asn His Leu Ala Val Leu Glu Lys Arg Val Glu Leu Glu Gly 
            180                 185                 190         


Leu Lys Val Val Glu Ile Glu Lys Cys Lys Ser Asp Ile Lys Lys Met 
        195                 200                 205             


Arg Glu Glu Leu Ala Ala Arg Ser Ser Arg Thr Asn Cys Pro Cys Lys 
    210                 215                 220                 


Tyr Ser Phe Leu Asp Asn His Lys Lys Leu Thr Pro Arg Arg Asp Val 
225                 230                 235                 240 


Pro Thr Tyr Pro Lys Tyr Leu Leu Ser Pro Glu Thr Ile Glu Ala Leu 
                245                 250                 255     


Arg Lys Pro Thr Phe Asp Val Trp Leu Trp Glu Pro Asn Glu Met Leu 
            260                 265                 270         


Ser Cys Leu Glu His Met Tyr His Asp Leu Gly Leu Val Arg Asp Phe 
        275                 280                 285             


Ser Ile Asn Pro Val Thr Leu Arg Arg Trp Leu Phe Cys Val His Asp 
    290                 295                 300                 


Asn Tyr Arg Asn Asn Pro Phe His Asn Phe Arg His Cys Phe Cys Val 
305                 310                 315                 320 


Ala Gln Met Met Tyr Ser Met Val Trp Leu Cys Ser Leu Gln Glu Lys 
                325                 330                 335     


Phe Ser Gln Thr Asp Ile Leu Ile Leu Met Thr Ala Ala Ile Cys His 
            340                 345                 350         


Asp Leu Asp His Pro Gly Tyr Asn Asn Thr Tyr Gln Ile Asn Ala Arg 
        355                 360                 365             


Thr Glu Leu Ala Val Arg Tyr Asn Asp Ile Ser Pro Leu Glu Asn His 
    370                 375                 380                 


His Cys Ala Val Ala Phe Gln Ile Leu Ala Glu Pro Glu Cys Asn Ile 
385                 390                 395                 400 


Phe Ser Asn Ile Pro Pro Asp Gly Phe Lys Gln Ile Arg Gln Gly Met 
                405                 410                 415     


Ile Thr Leu Ile Leu Ala Thr Asp Met Ala Arg His Ala Glu Ile Met 
            420                 425                 430         


Asp Ser Phe Lys Glu Lys Met Glu Asn Phe Asp Tyr Ser Asn Glu Glu 
        435                 440                 445             


His Met Thr Leu Leu Lys Met Ile Leu Ile Lys Cys Cys Asp Ile Ser 
    450                 455                 460                 


Asn Glu Val Arg Pro Met Glu Val Ala Glu Pro Trp Val Asp Cys Leu 
465                 470                 475                 480 


Leu Glu Glu Tyr Phe Met Gln Ser Asp Arg Glu Lys Ser Glu Gly Leu 
                485                 490                 495     


Pro Val Ala Pro Phe Met Asp Arg Asp Lys Val Thr Lys Ala Thr Ala 
            500                 505                 510         


Gln Ile Gly Phe Ile Lys Phe Val Leu Ile Pro Met Phe Glu Thr Val 
        515                 520                 525             


Thr Lys Leu Phe Pro Met Val Glu Glu Ile Met Leu Gln Pro Leu Trp 
    530                 535                 540                 


Glu Ser Arg Asp Arg Tyr Glu Glu Leu Lys Arg Ile Asp Asp Ala Met 
545                 550                 555                 560 


Lys Glu Leu Gln Lys Lys Thr Asp Ser Leu Thr Ser Gly Ala Thr Glu 
                565                 570                 575     


Lys Ser Arg Glu Arg Ser Arg Asp Val Lys Asn Ser Glu Gly Asp Cys 
            580                 585                 590         


Ala 
    


<210>  15
<211>  243
<212>  DNA
<213>  Homo sapiens

<400>  15
atgggcagca cgctgaggaa acgcaagatg tacgaggagt tcctcagcaa ggtctccatc       60

ctagagtccc tggagaagtg ggagcgtctg accgtggcgg atgcgctgga gcccgtccag      120

tttgaagatg gagagaaaat cgtggtccag ggagagcctg gggacgactt ttacatcatc      180

acggagaaaa atttgccggg tgtggtggca catgcctgta atcccagcta cttgggaggc      240

tga                                                                    243


<210>  16
<211>  80
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Gly Ser Thr Leu Arg Lys Arg Lys Met Tyr Glu Glu Phe Leu Ser 
1               5                   10                  15      


Lys Val Ser Ile Leu Glu Ser Leu Glu Lys Trp Glu Arg Leu Thr Val 
            20                  25                  30          


Ala Asp Ala Leu Glu Pro Val Gln Phe Glu Asp Gly Glu Lys Ile Val 
        35                  40                  45              


Val Gln Gly Glu Pro Gly Asp Asp Phe Tyr Ile Ile Thr Glu Lys Asn 
    50                  55                  60                  


Leu Pro Gly Val Val Ala His Ala Cys Asn Pro Ser Tyr Leu Gly Gly 
65                  70                  75                  80  


<210>  17
<211>  2139
<212>  DNA
<213>  Homo sapiens

<400>  17
atggagaacc tgggggtcgg cgaaggggca gaggcttgca gcaggttgag tcgctctcgc       60

ggccgccaca gcatgaccag agccccgaag cacctgtggc ggcaaccccg gcgccccatc      120

cgcatccaac agcgcttcta ttcggatccg gacaagtccg cgggctgccg cgagagggac      180

ctgagcccgc ggccggagct caggaagtcg cggctctcct ggcccgtttc ctcctgcagg      240

cgctttgacc tggaaaatgg gctctcgtgt gggaggaggg ccctggaccc tcagtccagc      300

cctggcctgg gccggattat gcaggctcca gtcccgcaca gccagcggcg cgagtccttc      360

ctgtaccgct cagatagcga ctatgaactc tcgcccaagg ccatgtctcg gaactcctct      420

gtggccagcg acctacatgg agaggacatg attgtgacgc cctttgccca ggtcctggcc      480

agtctgcgga ccgttcggag caacgtggcg gcccttgccc gccagcaatg cctaggagca      540

gccaagcagg gacccgtcgg aaacccttca tccagcaatc agctccctcc tgcagaggac      600

acggggcaga agctggcatt ggagacgcta gacgagctgg actggtgcct ggatcagttg      660

gagacgctgc agacccggca ctcggtgggg gagatggcct ccaacaagtt caagcggatc      720

ctgaaccggg agttgaccca cctgtccgaa accagccgct ccgggaacca ggtgtccgag      780

tacatctccc ggaccttcct ggaccagcag accgaggtgg agctgcccaa ggtgaccgct      840

gaggaggccc cacagcccat gtcccggatc agtggcctac atgggctctg ccacagtgcc      900

agcctctcct cagccactgt cccacgcttt ggggtccaga ctgaccagga ggagcaactg      960

gccaaggagc tagaagacac caacaagtgg ggacttgatg tgttcaaggt ggcggagcta     1020

agtgggaacc ggcccctcac agctatcata ttcagcattt ttcaggagcg ggacctgctg     1080

aagacattcc agatcccagc agacacactg gccacctacc tgctgatgct ggaaggtcac     1140

taccacgcca atgtggccta ccacaacagc ctacatgccg ccgacgtggc ccagtccacg     1200

catgtgctgc tggctacgcc cgccctcgag gctgtgttca cagacttgga aatcctggct     1260

gccctctttg caagcgccat ccacgacgtg gaccatcctg gggtctccaa ccagtttctg     1320

attaacacca actcagagct ggcgcttatg tacaacgacg cctcggtgct ggagaaccat     1380

cacctggctg tgggcttcaa gctgctgcag gcagagaact gcgatatctt ccagaacctc     1440

agcgccaagc agcgactgag tctgcgcagg atggtcattg acatggtgct ggccacagac     1500

atgtccaaac acatgaacct cctggccgac ctcaagacca tggtggagac caagaaggtg     1560

acaagcctcg gtgtcctcct cctggacaac tattccgacc gaatccaggt cttgcagaac     1620

ctggtgcact gtgctgatct gagcaacccc accaagccgc tgcccctgta ccgccagtgg     1680

acggaccgca tcatggccga gttcttccag cagggagacc gcgagcgtga gtcgggcctg     1740

gacatcagtc ccatgtgtga caagcatacg gcctcagtgg agaagtccca ggtgggtttc     1800

attgactaca ttgctcaccc actgtgggag acttgggctg acctggtcca cccagatgca     1860

caggacctgc tggacacgct ggaggacaat cgagagtggt accagagcaa gatcccccga     1920

agtccctcag acctcaccaa ccccgagcgg gacgggcctg acagattcca gtttgaactg     1980

actctggagg aggcagagga agaggatgag gaggaagaag aggaggggga agagacagct     2040

ttagccaaag aggccttgga gttgcctgac actgaactcc tgtcccctga agccggccca     2100

gaccctgggg acttacccct cgacaaccag aggacttag                            2139


<210>  18
<211>  712
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Glu Asn Leu Gly Val Gly Glu Gly Ala Glu Ala Cys Ser Arg Leu 
1               5                   10                  15      


Ser Arg Ser Arg Gly Arg His Ser Met Thr Arg Ala Pro Lys His Leu 
            20                  25                  30          


Trp Arg Gln Pro Arg Arg Pro Ile Arg Ile Gln Gln Arg Phe Tyr Ser 
        35                  40                  45              


Asp Pro Asp Lys Ser Ala Gly Cys Arg Glu Arg Asp Leu Ser Pro Arg 
    50                  55                  60                  


Pro Glu Leu Arg Lys Ser Arg Leu Ser Trp Pro Val Ser Ser Cys Arg 
65                  70                  75                  80  


Arg Phe Asp Leu Glu Asn Gly Leu Ser Cys Gly Arg Arg Ala Leu Asp 
                85                  90                  95      


Pro Gln Ser Ser Pro Gly Leu Gly Arg Ile Met Gln Ala Pro Val Pro 
            100                 105                 110         


His Ser Gln Arg Arg Glu Ser Phe Leu Tyr Arg Ser Asp Ser Asp Tyr 
        115                 120                 125             


Glu Leu Ser Pro Lys Ala Met Ser Arg Asn Ser Ser Val Ala Ser Asp 
    130                 135                 140                 


Leu His Gly Glu Asp Met Ile Val Thr Pro Phe Ala Gln Val Leu Ala 
145                 150                 155                 160 


Ser Leu Arg Thr Val Arg Ser Asn Val Ala Ala Leu Ala Arg Gln Gln 
                165                 170                 175     


Cys Leu Gly Ala Ala Lys Gln Gly Pro Val Gly Asn Pro Ser Ser Ser 
            180                 185                 190         


Asn Gln Leu Pro Pro Ala Glu Asp Thr Gly Gln Lys Leu Ala Leu Glu 
        195                 200                 205             


Thr Leu Asp Glu Leu Asp Trp Cys Leu Asp Gln Leu Glu Thr Leu Gln 
    210                 215                 220                 


Thr Arg His Ser Val Gly Glu Met Ala Ser Asn Lys Phe Lys Arg Ile 
225                 230                 235                 240 


Leu Asn Arg Glu Leu Thr His Leu Ser Glu Thr Ser Arg Ser Gly Asn 
                245                 250                 255     


Gln Val Ser Glu Tyr Ile Ser Arg Thr Phe Leu Asp Gln Gln Thr Glu 
            260                 265                 270         


Val Glu Leu Pro Lys Val Thr Ala Glu Glu Ala Pro Gln Pro Met Ser 
        275                 280                 285             


Arg Ile Ser Gly Leu His Gly Leu Cys His Ser Ala Ser Leu Ser Ser 
    290                 295                 300                 


Ala Thr Val Pro Arg Phe Gly Val Gln Thr Asp Gln Glu Glu Gln Leu 
305                 310                 315                 320 


Ala Lys Glu Leu Glu Asp Thr Asn Lys Trp Gly Leu Asp Val Phe Lys 
                325                 330                 335     


Val Ala Glu Leu Ser Gly Asn Arg Pro Leu Thr Ala Ile Ile Phe Ser 
            340                 345                 350         


Ile Phe Gln Glu Arg Asp Leu Leu Lys Thr Phe Gln Ile Pro Ala Asp 
        355                 360                 365             


Thr Leu Ala Thr Tyr Leu Leu Met Leu Glu Gly His Tyr His Ala Asn 
    370                 375                 380                 


Val Ala Tyr His Asn Ser Leu His Ala Ala Asp Val Ala Gln Ser Thr 
385                 390                 395                 400 


His Val Leu Leu Ala Thr Pro Ala Leu Glu Ala Val Phe Thr Asp Leu 
                405                 410                 415     


Glu Ile Leu Ala Ala Leu Phe Ala Ser Ala Ile His Asp Val Asp His 
            420                 425                 430         


Pro Gly Val Ser Asn Gln Phe Leu Ile Asn Thr Asn Ser Glu Leu Ala 
        435                 440                 445             


Leu Met Tyr Asn Asp Ala Ser Val Leu Glu Asn His His Leu Ala Val 
    450                 455                 460                 


Gly Phe Lys Leu Leu Gln Ala Glu Asn Cys Asp Ile Phe Gln Asn Leu 
465                 470                 475                 480 


Ser Ala Lys Gln Arg Leu Ser Leu Arg Arg Met Val Ile Asp Met Val 
                485                 490                 495     


Leu Ala Thr Asp Met Ser Lys His Met Asn Leu Leu Ala Asp Leu Lys 
            500                 505                 510         


Thr Met Val Glu Thr Lys Lys Val Thr Ser Leu Gly Val Leu Leu Leu 
        515                 520                 525             


Asp Asn Tyr Ser Asp Arg Ile Gln Val Leu Gln Asn Leu Val His Cys 
    530                 535                 540                 


Ala Asp Leu Ser Asn Pro Thr Lys Pro Leu Pro Leu Tyr Arg Gln Trp 
545                 550                 555                 560 


Thr Asp Arg Ile Met Ala Glu Phe Phe Gln Gln Gly Asp Arg Glu Arg 
                565                 570                 575     


Glu Ser Gly Leu Asp Ile Ser Pro Met Cys Asp Lys His Thr Ala Ser 
            580                 585                 590         


Val Glu Lys Ser Gln Val Gly Phe Ile Asp Tyr Ile Ala His Pro Leu 
        595                 600                 605             


Trp Glu Thr Trp Ala Asp Leu Val His Pro Asp Ala Gln Asp Leu Leu 
    610                 615                 620                 


Asp Thr Leu Glu Asp Asn Arg Glu Trp Tyr Gln Ser Lys Ile Pro Arg 
625                 630                 635                 640 


Ser Pro Ser Asp Leu Thr Asn Pro Glu Arg Asp Gly Pro Asp Arg Phe 
                645                 650                 655     


Gln Phe Glu Leu Thr Leu Glu Glu Ala Glu Glu Glu Asp Glu Glu Glu 
            660                 665                 670         


Glu Glu Glu Gly Glu Glu Thr Ala Leu Ala Lys Glu Ala Leu Glu Leu 
        675                 680                 685             


Pro Asp Thr Glu Leu Leu Ser Pro Glu Ala Gly Pro Asp Pro Gly Asp 
    690                 695                 700                 


Leu Pro Leu Asp Asn Gln Arg Thr 
705                 710         


<210>  19
<211>  1161
<212>  DNA
<213>  Homo sapiens

<400>  19
atgagagctg cacccctcct cctggccagg gcagcaagcc ttagccttgg cttcttgttt       60

ctgctttttt tctggctaga ccgaagtgta ctagccaagg agttgaagtt tgtgactttg      120

gtgtttcggc atggagaccg aagtcccatt gacacctttc ccactgaccc cataaaggaa      180

tcctcatggc cacaaggatt tggccaactc acccagctgg gcatggagca gcattatgaa      240

cttggagagt atataagaaa gagatataga aaattcttga atgagtccta taaacatgaa      300

caggtttata ttcgaagcac agacgttgac cggactttga tgagtgctat gacaaacctg      360

gcagccctgt ttcccccaga aggtgtcagc atctggaatc ctatcctact ctggcagccc      420

atcccggtgc acacagttcc tctttctgaa gatcagttgc tatacctgcc tttcaggaac      480

tgccctcgtt ttcaagaact tgagagtgag actttgaaat cagaggaatt ccagaagagg      540

ctgcaccctt ataaggattt tatagctacc ttgggaaaac tttcaggatt acatggccag      600

gacctttttg gaatttggag taaagtctac gaccctttat attgtgagag tgttcacaat      660

ttcactttac cctcctgggc cactgaggac accatgacta agttgagaga attgtcagaa      720

ttgtccctcc tgtccctcta tggaattcac aagcagaaag agaaatctag gctccaaggg      780

ggtgtcctgg tcaatgaaat cctcaatcac atgaagagag caactcagat accaagctac      840

aaaaaactca tcatgtattc tgcgcatgac actactgtga gtggcctaca gatggcgcta      900

gatgtttaca acggactcct tcctccctat gcttcttgcc acttgacgga attgtacttt      960

gagaaggggg agtactttgt ggagatgtac tatcggaatg agacgcagca cgagccgtat     1020

cccctcatgc tacctggctg cagccccagc tgtcctctgg agaggtttgc tgagctggtt     1080

ggccctgtga tccctcaaga ctggtccacg gagtgtatga ccacaaacag ccatcaaggt     1140

actgaagaca gtacagatta g                                               1161


<210>  20
<211>  386
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Arg Ala Ala Pro Leu Leu Leu Ala Arg Ala Ala Ser Leu Ser Leu 
1               5                   10                  15      


Gly Phe Leu Phe Leu Leu Phe Phe Trp Leu Asp Arg Ser Val Leu Ala 
            20                  25                  30          


Lys Glu Leu Lys Phe Val Thr Leu Val Phe Arg His Gly Asp Arg Ser 
        35                  40                  45              


Pro Ile Asp Thr Phe Pro Thr Asp Pro Ile Lys Glu Ser Ser Trp Pro 
    50                  55                  60                  


Gln Gly Phe Gly Gln Leu Thr Gln Leu Gly Met Glu Gln His Tyr Glu 
65                  70                  75                  80  


Leu Gly Glu Tyr Ile Arg Lys Arg Tyr Arg Lys Phe Leu Asn Glu Ser 
                85                  90                  95      


Tyr Lys His Glu Gln Val Tyr Ile Arg Ser Thr Asp Val Asp Arg Thr 
            100                 105                 110         


Leu Met Ser Ala Met Thr Asn Leu Ala Ala Leu Phe Pro Pro Glu Gly 
        115                 120                 125             


Val Ser Ile Trp Asn Pro Ile Leu Leu Trp Gln Pro Ile Pro Val His 
    130                 135                 140                 


Thr Val Pro Leu Ser Glu Asp Gln Leu Leu Tyr Leu Pro Phe Arg Asn 
145                 150                 155                 160 


Cys Pro Arg Phe Gln Glu Leu Glu Ser Glu Thr Leu Lys Ser Glu Glu 
                165                 170                 175     


Phe Gln Lys Arg Leu His Pro Tyr Lys Asp Phe Ile Ala Thr Leu Gly 
            180                 185                 190         


Lys Leu Ser Gly Leu His Gly Gln Asp Leu Phe Gly Ile Trp Ser Lys 
        195                 200                 205             


Val Tyr Asp Pro Leu Tyr Cys Glu Ser Val His Asn Phe Thr Leu Pro 
    210                 215                 220                 


Ser Trp Ala Thr Glu Asp Thr Met Thr Lys Leu Arg Glu Leu Ser Glu 
225                 230                 235                 240 


Leu Ser Leu Leu Ser Leu Tyr Gly Ile His Lys Gln Lys Glu Lys Ser 
                245                 250                 255     


Arg Leu Gln Gly Gly Val Leu Val Asn Glu Ile Leu Asn His Met Lys 
            260                 265                 270         


Arg Ala Thr Gln Ile Pro Ser Tyr Lys Lys Leu Ile Met Tyr Ser Ala 
        275                 280                 285             


His Asp Thr Thr Val Ser Gly Leu Gln Met Ala Leu Asp Val Tyr Asn 
    290                 295                 300                 


Gly Leu Leu Pro Pro Tyr Ala Ser Cys His Leu Thr Glu Leu Tyr Phe 
305                 310                 315                 320 


Glu Lys Gly Glu Tyr Phe Val Glu Met Tyr Tyr Arg Asn Glu Thr Gln 
                325                 330                 335     


His Glu Pro Tyr Pro Leu Met Leu Pro Gly Cys Ser Pro Ser Cys Pro 
            340                 345                 350         


Leu Glu Arg Phe Ala Glu Leu Val Gly Pro Val Ile Pro Gln Asp Trp 
        355                 360                 365             


Ser Thr Glu Cys Met Thr Thr Asn Ser His Gln Gly Thr Glu Asp Ser 
    370                 375                 380                 


Thr Asp 
385     


<210>  21
<211>  1134
<212>  DNA
<213>  Homo sapiens

<400>  21
atgtgcgacg aagacgagac caccgccctc gtgtgcgaca atggctccgg cctggtgaaa       60

gccggcttcg ccggggatga cgcccctagg gccgtgttcc cgtccatcgt gggccgcccc      120

cgacaccagg gcgtcatggt cggtatgggt cagaaagatt cctacgtggg cgacgaggct      180

cagagcaaga gaggtatcct gaccctgaag taccctatcg agcacggcat catcaccaac      240

tgggatgaca tggagaagat ctggcaccac accttctaca acgagcttcg cgtggctccc      300

gaggagcacc ccaccctgct caccgaggcc cccctcaatc ccaaggccaa ccgcgagaag      360

atgacccaga tcatgtttga gaccttcaac gtgcccgcca tgtacgtggc catccaggcc      420

gtgctgtccc tctacgcctc cggcaggacc accggcatcg tgctggactc cggcgacggc      480

gtcacccaca acgtgcccat ttatgagggc tacgcgctgc cgcacgccat catgcgcctg      540

gacctggcgg gccgcgatct caccgactac ctgatgaaga tcctcactga gcgtggctac      600

tccttcgtga ccacagctga gcgcgagatc gtgcgcgaca tcaaggagaa gctgtgctac      660

gtggccctgg acttcgagaa cgagatggcg acggccgcct cctcctcctc cctggaaaag      720

agctacgagc tgccagacgg gcaggtcatc accatcggca acgagcgctt ccgctgcccg      780

gagacgctct tccagccctc cttcatcggt atggagtcgg cgggcattca cgagaccacc      840

tacaacagca tcatgaagtg tgacatcgac atcaggaagg acctgtatgc caacaacgtc      900

atgtcggggg gcaccacgat gtaccctggg atcgctgacc gcatgcagaa agagatcacc      960

gcgctggcac ccagcaccat gaagatcaag atcatcgccc cgccggagcg caaatactcg     1020

gtgtggatcg gcggctccat cctggcctcg ctgtccacct tccagcagat gtggatcacc     1080

aagcaggagt acgacgaggc cggcccttcc atcgtccacc gcaaatgctt ctag           1134


<210>  22
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Cys Asp Glu Asp Glu Thr Thr Ala Leu Val Cys Asp Asn Gly Ser 
1               5                   10                  15      


Gly Leu Val Lys Ala Gly Phe Ala Gly Asp Asp Ala Pro Arg Ala Val 
            20                  25                  30          


Phe Pro Ser Ile Val Gly Arg Pro Arg His Gln Gly Val Met Val Gly 
        35                  40                  45              


Met Gly Gln Lys Asp Ser Tyr Val Gly Asp Glu Ala Gln Ser Lys Arg 
    50                  55                  60                  


Gly Ile Leu Thr Leu Lys Tyr Pro Ile Glu His Gly Ile Ile Thr Asn 
65                  70                  75                  80  


Trp Asp Asp Met Glu Lys Ile Trp His His Thr Phe Tyr Asn Glu Leu 
                85                  90                  95      


Arg Val Ala Pro Glu Glu His Pro Thr Leu Leu Thr Glu Ala Pro Leu 
            100                 105                 110         


Asn Pro Lys Ala Asn Arg Glu Lys Met Thr Gln Ile Met Phe Glu Thr 
        115                 120                 125             


Phe Asn Val Pro Ala Met Tyr Val Ala Ile Gln Ala Val Leu Ser Leu 
    130                 135                 140                 


Tyr Ala Ser Gly Arg Thr Thr Gly Ile Val Leu Asp Ser Gly Asp Gly 
145                 150                 155                 160 


Val Thr His Asn Val Pro Ile Tyr Glu Gly Tyr Ala Leu Pro His Ala 
                165                 170                 175     


Ile Met Arg Leu Asp Leu Ala Gly Arg Asp Leu Thr Asp Tyr Leu Met 
            180                 185                 190         


Lys Ile Leu Thr Glu Arg Gly Tyr Ser Phe Val Thr Thr Ala Glu Arg 
        195                 200                 205             


Glu Ile Val Arg Asp Ile Lys Glu Lys Leu Cys Tyr Val Ala Leu Asp 
    210                 215                 220                 


Phe Glu Asn Glu Met Ala Thr Ala Ala Ser Ser Ser Ser Leu Glu Lys 
225                 230                 235                 240 


Ser Tyr Glu Leu Pro Asp Gly Gln Val Ile Thr Ile Gly Asn Glu Arg 
                245                 250                 255     


Phe Arg Cys Pro Glu Thr Leu Phe Gln Pro Ser Phe Ile Gly Met Glu 
            260                 265                 270         


Ser Ala Gly Ile His Glu Thr Thr Tyr Asn Ser Ile Met Lys Cys Asp 
        275                 280                 285             


Ile Asp Ile Arg Lys Asp Leu Tyr Ala Asn Asn Val Met Ser Gly Gly 
    290                 295                 300                 


Thr Thr Met Tyr Pro Gly Ile Ala Asp Arg Met Gln Lys Glu Ile Thr 
305                 310                 315                 320 


Ala Leu Ala Pro Ser Thr Met Lys Ile Lys Ile Ile Ala Pro Pro Glu 
                325                 330                 335     


Arg Lys Tyr Ser Val Trp Ile Gly Gly Ser Ile Leu Ala Ser Leu Ser 
            340                 345                 350         


Thr Phe Gln Gln Met Trp Ile Thr Lys Gln Glu Tyr Asp Glu Ala Gly 
        355                 360                 365             


Pro Ser Ile Val His Arg Lys Cys Phe 
    370                 375         


<210>  23
<211>  1149
<212>  DNA
<213>  Homo sapiens

<400>  23
atggcactgc agggcatctc ggtcgtggag ctgtccggcc tggccccggg cccgttctgt       60

gctatggtcc tggctgactt cggggcgcgt gtggtacgcg tggaccggcc cggctcccgc      120

tacgacgtga gccgcttggg ccggggcaag cgctcgctag tgctggacct gaagcagccg      180

cggggagccg ccgtgctgcg gcgtctgtgc aagcggtcgg atgtgctgct ggagcccttc      240

cgccgcggtg tcatggagaa actccagctg ggcccagaga ttctgcagcg ggaaaatcca      300

aggcttattt atgccaggct gagtggattt ggccagtcag gaagcttctg ccggttagct      360

ggccacgata tcaactattt ggctttgtca ggtgttctct caaaaattgg cagaagtggt      420

gagaatccgt atgccccgct gaatctcctg gctgactttg ctggtggtgg ccttatgtgt      480

gcactgggca ttataatggc tctttttgac cgcacacgca ctggcaaggg tcaggtcatt      540

gatgcaaata tggtggaagg aacagcatat ttaagttctt ttctgtggaa aactcagaaa      600

tcgagtctgt gggaagcacc tcgaggacag aacatgttgg atggtggagc acctttctat      660

acgacttaca ggacagcaga tggggaattc atggctgttg gagcaataga accccagttc      720

tacgagctgc tgatcaaagg acttggacta aagtctgatg aacttcccaa tcagatgagc      780

atggatgatt ggccagaaat gaagaagaag tttgcagatg tatttgcaaa gaagacgaag      840

gcagagtggt gtcaaatctt tgacggcaca gatgcctgtg tgactccggt tctgactttt      900

gaggaggttg ttcatcatga tcacaacaag gaacggggct cgtttatcac cagtgaggag      960

caggacgtga gcccccgccc tgcacctctg ctgttaaaca ccccagccat cccttctttc     1020

aaaagggatc ctttcatagg agaacacact gaggagatac ttgaagaatt tggattcagc     1080

cgcgaagaga tttatcagct taactcagat aaaatcattg aaagtaataa ggtaaaagct     1140

agtctctaa                                                             1149


<210>  24
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Ala Leu Gln Gly Ile Ser Val Val Glu Leu Ser Gly Leu Ala Pro 
1               5                   10                  15      


Gly Pro Phe Cys Ala Met Val Leu Ala Asp Phe Gly Ala Arg Val Val 
            20                  25                  30          


Arg Val Asp Arg Pro Gly Ser Arg Tyr Asp Val Ser Arg Leu Gly Arg 
        35                  40                  45              


Gly Lys Arg Ser Leu Val Leu Asp Leu Lys Gln Pro Arg Gly Ala Ala 
    50                  55                  60                  


Val Leu Arg Arg Leu Cys Lys Arg Ser Asp Val Leu Leu Glu Pro Phe 
65                  70                  75                  80  


Arg Arg Gly Val Met Glu Lys Leu Gln Leu Gly Pro Glu Ile Leu Gln 
                85                  90                  95      


Arg Glu Asn Pro Arg Leu Ile Tyr Ala Arg Leu Ser Gly Phe Gly Gln 
            100                 105                 110         


Ser Gly Ser Phe Cys Arg Leu Ala Gly His Asp Ile Asn Tyr Leu Ala 
        115                 120                 125             


Leu Ser Gly Val Leu Ser Lys Ile Gly Arg Ser Gly Glu Asn Pro Tyr 
    130                 135                 140                 


Ala Pro Leu Asn Leu Leu Ala Asp Phe Ala Gly Gly Gly Leu Met Cys 
145                 150                 155                 160 


Ala Leu Gly Ile Ile Met Ala Leu Phe Asp Arg Thr Arg Thr Gly Lys 
                165                 170                 175     


Gly Gln Val Ile Asp Ala Asn Met Val Glu Gly Thr Ala Tyr Leu Ser 
            180                 185                 190         


Ser Phe Leu Trp Lys Thr Gln Lys Ser Ser Leu Trp Glu Ala Pro Arg 
        195                 200                 205             


Gly Gln Asn Met Leu Asp Gly Gly Ala Pro Phe Tyr Thr Thr Tyr Arg 
    210                 215                 220                 


Thr Ala Asp Gly Glu Phe Met Ala Val Gly Ala Ile Glu Pro Gln Phe 
225                 230                 235                 240 


Tyr Glu Leu Leu Ile Lys Gly Leu Gly Leu Lys Ser Asp Glu Leu Pro 
                245                 250                 255     


Asn Gln Met Ser Met Asp Asp Trp Pro Glu Met Lys Lys Lys Phe Ala 
            260                 265                 270         


Asp Val Phe Ala Lys Lys Thr Lys Ala Glu Trp Cys Gln Ile Phe Asp 
        275                 280                 285             


Gly Thr Asp Ala Cys Val Thr Pro Val Leu Thr Phe Glu Glu Val Val 
    290                 295                 300                 


His His Asp His Asn Lys Glu Arg Gly Ser Phe Ile Thr Ser Glu Glu 
305                 310                 315                 320 


Gln Asp Val Ser Pro Arg Pro Ala Pro Leu Leu Leu Asn Thr Pro Ala 
                325                 330                 335     


Ile Pro Ser Phe Lys Arg Asp Pro Phe Ile Gly Glu His Thr Glu Glu 
            340                 345                 350         


Ile Leu Glu Glu Phe Gly Phe Ser Arg Glu Glu Ile Tyr Gln Leu Asn 
        355                 360                 365             


Ser Asp Lys Ile Ile Glu Ser Asn Lys Val Lys Ala Ser Leu 
    370                 375                 380         


<210>  25
<211>  1041
<212>  DNA
<213>  Homo sapiens

<400>  25
atggcaatgg tatcagaatt cctcaagcag gcctggttta ttgaaaatga agagcaggaa       60

tatgttcaaa ctgtgaagtc atccaaaggt ggtcccggat cagcggtgag cccctatcct      120

accttcaatc catcctcgga tgtcgctgcc ttgcataagg ccataatggt taaaggtgtg      180

gatgaagcaa ccatcattga cattctaact aagcgaaaca atgcacagcg tcaacagatc      240

aaagcagcat atctccagga aacaggaaag cccctggatg aaacactgaa gaaagccctt      300

acaggtcacc ttgaggaggt tgttttagct ctgctaaaaa ctccagcgca atttgatgct      360

gatgaacttc gtgctgccat gaagggcctt ggaactgatg aagatactct aattgagatt      420

ttggcatcaa gaactaacaa agaaatcaga gacattaaca gggtctacag agaggaactg      480

aagagagatc tggccaaaga cataacctca gacacatctg gagattttcg gaacgctttg      540

ctttctcttg ctaagggtga ccgatctgag gactttggtg tgaatgaaga cttggctgat      600

tcagatgcca gggccttgta tgaagcagga gaaaggagaa aggggacaga cgtaaacgtg      660

ttcaatacca tccttaccac cagaagctat ccacaacttc gcagagtgtt tcagaaatac      720

accaagtaca gtaagcatga catgaacaaa gttctggacc tggagttgaa aggtgacatt      780

gagaaatgcc tcacagctat cgtgaagtgc gccacaagca aaccagcttt ctttgcagag      840

aagcttcatc aagccatgaa aggtgttgga actcgccata aggcattgat caggattatg      900

gtttcccgtt ctgaaattga catgaatgat atcaaagcat tctatcagaa gatgtatggt      960

atctcccttt gccaagccat cctggatgaa accaaaggag attatgagaa aatcctggtg     1020

gctctttgtg gaggaaacta a                                               1041


<210>  26
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Ala Met Val Ser Glu Phe Leu Lys Gln Ala Trp Phe Ile Glu Asn 
1               5                   10                  15      


Glu Glu Gln Glu Tyr Val Gln Thr Val Lys Ser Ser Lys Gly Gly Pro 
            20                  25                  30          


Gly Ser Ala Val Ser Pro Tyr Pro Thr Phe Asn Pro Ser Ser Asp Val 
        35                  40                  45              


Ala Ala Leu His Lys Ala Ile Met Val Lys Gly Val Asp Glu Ala Thr 
    50                  55                  60                  


Ile Ile Asp Ile Leu Thr Lys Arg Asn Asn Ala Gln Arg Gln Gln Ile 
65                  70                  75                  80  


Lys Ala Ala Tyr Leu Gln Glu Thr Gly Lys Pro Leu Asp Glu Thr Leu 
                85                  90                  95      


Lys Lys Ala Leu Thr Gly His Leu Glu Glu Val Val Leu Ala Leu Leu 
            100                 105                 110         


Lys Thr Pro Ala Gln Phe Asp Ala Asp Glu Leu Arg Ala Ala Met Lys 
        115                 120                 125             


Gly Leu Gly Thr Asp Glu Asp Thr Leu Ile Glu Ile Leu Ala Ser Arg 
    130                 135                 140                 


Thr Asn Lys Glu Ile Arg Asp Ile Asn Arg Val Tyr Arg Glu Glu Leu 
145                 150                 155                 160 


Lys Arg Asp Leu Ala Lys Asp Ile Thr Ser Asp Thr Ser Gly Asp Phe 
                165                 170                 175     


Arg Asn Ala Leu Leu Ser Leu Ala Lys Gly Asp Arg Ser Glu Asp Phe 
            180                 185                 190         


Gly Val Asn Glu Asp Leu Ala Asp Ser Asp Ala Arg Ala Leu Tyr Glu 
        195                 200                 205             


Ala Gly Glu Arg Arg Lys Gly Thr Asp Val Asn Val Phe Asn Thr Ile 
    210                 215                 220                 


Leu Thr Thr Arg Ser Tyr Pro Gln Leu Arg Arg Val Phe Gln Lys Tyr 
225                 230                 235                 240 


Thr Lys Tyr Ser Lys His Asp Met Asn Lys Val Leu Asp Leu Glu Leu 
                245                 250                 255     


Lys Gly Asp Ile Glu Lys Cys Leu Thr Ala Ile Val Lys Cys Ala Thr 
            260                 265                 270         


Ser Lys Pro Ala Phe Phe Ala Glu Lys Leu His Gln Ala Met Lys Gly 
        275                 280                 285             


Val Gly Thr Arg His Lys Ala Leu Ile Arg Ile Met Val Ser Arg Ser 
    290                 295                 300                 


Glu Ile Asp Met Asn Asp Ile Lys Ala Phe Tyr Gln Lys Met Tyr Gly 
305                 310                 315                 320 


Ile Ser Leu Cys Gln Ala Ile Leu Asp Glu Thr Lys Gly Asp Tyr Glu 
                325                 330                 335     


Lys Ile Leu Val Ala Leu Cys Gly Gly Asn 
            340                 345     


<210>  27
<211>  1467
<212>  DNA
<213>  Homo sapiens

<400>  27
atgtcatacc caggctatcc cccaacaggc tacccacctt tccctggata tcctcctgca       60

ggtcaggagt catcttttcc cccttctggt cagtatcctt atcctagtgg ctttcctcca      120

atgggaggag gtgcctaccc acaagtgcca agtagtggct acccaggagc tggaggctac      180

cctgcgcctg gaggttatcc agcccctgga ggctatcctg gtgccccaca gccaggggga      240

gctccatcct atcccggagt tcctccaggc caaggatttg gagtcccacc aggtggagca      300

ggcttttctg ggtatccaca gccaccttca cagtcttatg gaggtggtcc agcacaggtt      360

ccactacctg gtggctttcc tggaggacag atgccttctc agtatcctgg aggacaacct      420

acttacccta gtcagatcaa tacagattct ttttcttcct atcctgtttt ctctcctgtt      480

tctttggatt atagcagtga acctgccaca gtgactcagg tcactcaagg aactatccga      540

ccagctgcca acttcgatgc tataagagat gcagaaattc ttcgtaaggc aatgaagggt      600

tttgggacag atgagcaggc aattgtggat gtggtggcca accgttccaa tgatcagagg      660

caaaaaatta aagcagcatt taagacctcc tatggcaagg atttaatcaa agatctcaaa      720

tcagagttaa gtggaaatat ggaagaactg atcctggccc tcttcatgcc tcctacgtat      780

tacgatgcct ggagcttacg gaaagcaatg cagggagcag gaactcagga acgtgtattg      840

attgagattt tgtgcacaag aacaaatcag gaaatccgag aaattgtcag atgttatcag      900

tcagaatttg gacgagacct tgaaaaggac attaggtcag atacatcagg acattttgaa      960

cgtttacttg tgtccatgtg ccagggaaat cgtgatgaga accagagtat aaaccaccaa     1020

atggctcagg aagatgctca gcgtctctat caagctggtg aggggagact agggaccgat     1080

gaatcttgct ttaacatgat ccttgccaca agaagctttc ctcagctgag agctaccatg     1140

gaggcttatt ctaggatggc taatcgagac ttgttaagca gtgtgagccg tgagttttcc     1200

ggatatgtag aaagtggttt gaagaccatc ttgcagtgtg ccctgaaccg ccctgccttc     1260

tttgctgaga ggctctacta tgctatgaaa ggtgctggca cagatgactc caccctggtc     1320

cggattgtgg tcactcgaag tgagattgac cttgtacaaa taaaacagat gttcgctcag     1380

atgtatcaga agactctggg cacaatgatt gcaggtgaca cgagtggaga ttaccgaaga     1440

cttcttctgg ctattgtggg ccagtag                                         1467


<210>  28
<211>  488
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Ser Tyr Pro Gly Tyr Pro Pro Thr Gly Tyr Pro Pro Phe Pro Gly 
1               5                   10                  15      


Tyr Pro Pro Ala Gly Gln Glu Ser Ser Phe Pro Pro Ser Gly Gln Tyr 
            20                  25                  30          


Pro Tyr Pro Ser Gly Phe Pro Pro Met Gly Gly Gly Ala Tyr Pro Gln 
        35                  40                  45              


Val Pro Ser Ser Gly Tyr Pro Gly Ala Gly Gly Tyr Pro Ala Pro Gly 
    50                  55                  60                  


Gly Tyr Pro Ala Pro Gly Gly Tyr Pro Gly Ala Pro Gln Pro Gly Gly 
65                  70                  75                  80  


Ala Pro Ser Tyr Pro Gly Val Pro Pro Gly Gln Gly Phe Gly Val Pro 
                85                  90                  95      


Pro Gly Gly Ala Gly Phe Ser Gly Tyr Pro Gln Pro Pro Ser Gln Ser 
            100                 105                 110         


Tyr Gly Gly Gly Pro Ala Gln Val Pro Leu Pro Gly Gly Phe Pro Gly 
        115                 120                 125             


Gly Gln Met Pro Ser Gln Tyr Pro Gly Gly Gln Pro Thr Tyr Pro Ser 
    130                 135                 140                 


Gln Ile Asn Thr Asp Ser Phe Ser Ser Tyr Pro Val Phe Ser Pro Val 
145                 150                 155                 160 


Ser Leu Asp Tyr Ser Ser Glu Pro Ala Thr Val Thr Gln Val Thr Gln 
                165                 170                 175     


Gly Thr Ile Arg Pro Ala Ala Asn Phe Asp Ala Ile Arg Asp Ala Glu 
            180                 185                 190         


Ile Leu Arg Lys Ala Met Lys Gly Phe Gly Thr Asp Glu Gln Ala Ile 
        195                 200                 205             


Val Asp Val Val Ala Asn Arg Ser Asn Asp Gln Arg Gln Lys Ile Lys 
    210                 215                 220                 


Ala Ala Phe Lys Thr Ser Tyr Gly Lys Asp Leu Ile Lys Asp Leu Lys 
225                 230                 235                 240 


Ser Glu Leu Ser Gly Asn Met Glu Glu Leu Ile Leu Ala Leu Phe Met 
                245                 250                 255     


Pro Pro Thr Tyr Tyr Asp Ala Trp Ser Leu Arg Lys Ala Met Gln Gly 
            260                 265                 270         


Ala Gly Thr Gln Glu Arg Val Leu Ile Glu Ile Leu Cys Thr Arg Thr 
        275                 280                 285             


Asn Gln Glu Ile Arg Glu Ile Val Arg Cys Tyr Gln Ser Glu Phe Gly 
    290                 295                 300                 


Arg Asp Leu Glu Lys Asp Ile Arg Ser Asp Thr Ser Gly His Phe Glu 
305                 310                 315                 320 


Arg Leu Leu Val Ser Met Cys Gln Gly Asn Arg Asp Glu Asn Gln Ser 
                325                 330                 335     


Ile Asn His Gln Met Ala Gln Glu Asp Ala Gln Arg Leu Tyr Gln Ala 
            340                 345                 350         


Gly Glu Gly Arg Leu Gly Thr Asp Glu Ser Cys Phe Asn Met Ile Leu 
        355                 360                 365             


Ala Thr Arg Ser Phe Pro Gln Leu Arg Ala Thr Met Glu Ala Tyr Ser 
    370                 375                 380                 


Arg Met Ala Asn Arg Asp Leu Leu Ser Ser Val Ser Arg Glu Phe Ser 
385                 390                 395                 400 


Gly Tyr Val Glu Ser Gly Leu Lys Thr Ile Leu Gln Cys Ala Leu Asn 
                405                 410                 415     


Arg Pro Ala Phe Phe Ala Glu Arg Leu Tyr Tyr Ala Met Lys Gly Ala 
            420                 425                 430         


Gly Thr Asp Asp Ser Thr Leu Val Arg Ile Val Val Thr Arg Ser Glu 
        435                 440                 445             


Ile Asp Leu Val Gln Ile Lys Gln Met Phe Ala Gln Met Tyr Gln Lys 
    450                 455                 460                 


Thr Leu Gly Thr Met Ile Ala Gly Asp Thr Ser Gly Asp Tyr Arg Arg 
465                 470                 475                 480 


Leu Leu Leu Ala Ile Val Gly Gln 
                485             


<210>  29
<211>  537
<212>  DNA
<213>  Homo sapiens

<400>  29
atgccggctt accactcttc tctcatggat cctgatacca aactcatcgg aaacatggca       60

ctgttgccta tcagaagtca attcaaagga cctgccccca gagagacaaa agatacagat      120

attgtggatg aagccatcta ttacttcaag gccaatgtct tcttcaaaaa ctatgaaatt      180

aagaatgaag ctgataggac cttgatatat ataactctct acatttctga atgtctgaag      240

aaactgcaaa agtgcaattc caaaagccaa ggtgagaaag aaatgtatac gctgggaatc      300

actaattttc ccattcctgg agagcctggt tttccactta acgcaattta tgccaaacct      360

gcaaacaaac aggaagatga agtgatgaga gcctatttac aacagctaag gcaagagact      420

ggactgagac tttgtgagaa agttttcgac cctcagaatg ataaacccag caagtggtgg      480

acttgctttg tgaagagaca gttcatgaac aagagtcttt caggacctgg acagtga         537


<210>  30
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Pro Ala Tyr His Ser Ser Leu Met Asp Pro Asp Thr Lys Leu Ile 
1               5                   10                  15      


Gly Asn Met Ala Leu Leu Pro Ile Arg Ser Gln Phe Lys Gly Pro Ala 
            20                  25                  30          


Pro Arg Glu Thr Lys Asp Thr Asp Ile Val Asp Glu Ala Ile Tyr Tyr 
        35                  40                  45              


Phe Lys Ala Asn Val Phe Phe Lys Asn Tyr Glu Ile Lys Asn Glu Ala 
    50                  55                  60                  


Asp Arg Thr Leu Ile Tyr Ile Thr Leu Tyr Ile Ser Glu Cys Leu Lys 
65                  70                  75                  80  


Lys Leu Gln Lys Cys Asn Ser Lys Ser Gln Gly Glu Lys Glu Met Tyr 
                85                  90                  95      


Thr Leu Gly Ile Thr Asn Phe Pro Ile Pro Gly Glu Pro Gly Phe Pro 
            100                 105                 110         


Leu Asn Ala Ile Tyr Ala Lys Pro Ala Asn Lys Gln Glu Asp Glu Val 
        115                 120                 125             


Met Arg Ala Tyr Leu Gln Gln Leu Arg Gln Glu Thr Gly Leu Arg Leu 
    130                 135                 140                 


Cys Glu Lys Val Phe Asp Pro Gln Asn Asp Lys Pro Ser Lys Trp Trp 
145                 150                 155                 160 


Thr Cys Phe Val Lys Arg Gln Phe Met Asn Lys Ser Leu Ser Gly Pro 
                165                 170                 175     


Gly Gln 
        


<210>  31
<211>  1188
<212>  DNA
<213>  Homo sapiens

<400>  31
atgccgggcc ggagttgcgt cgccttagtc ctcctggctg ccgccgtcag ctgtgccgtc       60

gcgcagcacg cgccgccgtg gacagaggac tgcagaaaat caacctatcc tccttcagga      120

ccaacgtaca gaggtgcagt tccatggtac accataaatc ttgacttacc accctacaaa      180

agatggcatg aattgatgct tgacaaggca ccaatgctaa aggttatagt gaattctctg      240

aagaatatga taaatacatt cgtgccaagt ggaaaagtta tgcaggtggt ggatgaaaaa      300

ttgcctggcc tacttggcaa ctttcctggc ccttttgaag aggaaatgaa gggtattgcc      360

gctgttactg atataccttt aggagagatt atttcattca atatttttta tgaattattt      420

accatttgta cttcaatagt agcagaagac aaaaaaggtc atctaataca tgggagaaac      480

atggattttg gagtatttct tgggtggaac ataaataatg atacctgggt cataactgag      540

caactaaaac ctttaacagt gaatttggat ttccaaagaa acaacaaaac tgtcttcaag      600

gcttcaagct ttgctggcta tgtgggcatg ttaacaggat tcaaaccagg actgttcagt      660

cttacactga atgaacgttt cagtataaat ggtggttatc tgggtattct agaatggatt      720

ctgggaaaga aagatgccat gtggataggg ttcctcacta gaacagttct ggaaaatagc      780

acaagttatg aagaagccaa gaatttattg accaagacca agatattggc cccagcctac      840

tttatcctgg gaggcaacca gtctggggaa ggttgtgtga ttacacgaga cagaaaggaa      900

tcattggatg tatatgaact cgatgctaag cagggtagat ggtatgtggt acaaacaaat      960

tatgaccgtt ggaaacatcc cttcttcctt gatgatcgca gaacgcctgc aaagatgtgt     1020

ctgaaccgca ccagccaaga gaatatctca tttgaaacca tgtatgatgt cctgtcaaca     1080

aaacctgtcc tcaacaagct gaccgtatac acaaccttga tagatgttac caaaggtcaa     1140

ttcgaaactt acctgcggga ctgccctgac ccttgtatag gttggtga                  1188


<210>  32
<211>  395
<212>  PRT
<213>  Homo sapiens

<400>  32

Met Pro Gly Arg Ser Cys Val Ala Leu Val Leu Leu Ala Ala Ala Val 
1               5                   10                  15      


Ser Cys Ala Val Ala Gln His Ala Pro Pro Trp Thr Glu Asp Cys Arg 
            20                  25                  30          


Lys Ser Thr Tyr Pro Pro Ser Gly Pro Thr Tyr Arg Gly Ala Val Pro 
        35                  40                  45              


Trp Tyr Thr Ile Asn Leu Asp Leu Pro Pro Tyr Lys Arg Trp His Glu 
    50                  55                  60                  


Leu Met Leu Asp Lys Ala Pro Met Leu Lys Val Ile Val Asn Ser Leu 
65                  70                  75                  80  


Lys Asn Met Ile Asn Thr Phe Val Pro Ser Gly Lys Val Met Gln Val 
                85                  90                  95      


Val Asp Glu Lys Leu Pro Gly Leu Leu Gly Asn Phe Pro Gly Pro Phe 
            100                 105                 110         


Glu Glu Glu Met Lys Gly Ile Ala Ala Val Thr Asp Ile Pro Leu Gly 
        115                 120                 125             


Glu Ile Ile Ser Phe Asn Ile Phe Tyr Glu Leu Phe Thr Ile Cys Thr 
    130                 135                 140                 


Ser Ile Val Ala Glu Asp Lys Lys Gly His Leu Ile His Gly Arg Asn 
145                 150                 155                 160 


Met Asp Phe Gly Val Phe Leu Gly Trp Asn Ile Asn Asn Asp Thr Trp 
                165                 170                 175     


Val Ile Thr Glu Gln Leu Lys Pro Leu Thr Val Asn Leu Asp Phe Gln 
            180                 185                 190         


Arg Asn Asn Lys Thr Val Phe Lys Ala Ser Ser Phe Ala Gly Tyr Val 
        195                 200                 205             


Gly Met Leu Thr Gly Phe Lys Pro Gly Leu Phe Ser Leu Thr Leu Asn 
    210                 215                 220                 


Glu Arg Phe Ser Ile Asn Gly Gly Tyr Leu Gly Ile Leu Glu Trp Ile 
225                 230                 235                 240 


Leu Gly Lys Lys Asp Ala Met Trp Ile Gly Phe Leu Thr Arg Thr Val 
                245                 250                 255     


Leu Glu Asn Ser Thr Ser Tyr Glu Glu Ala Lys Asn Leu Leu Thr Lys 
            260                 265                 270         


Thr Lys Ile Leu Ala Pro Ala Tyr Phe Ile Leu Gly Gly Asn Gln Ser 
        275                 280                 285             


Gly Glu Gly Cys Val Ile Thr Arg Asp Arg Lys Glu Ser Leu Asp Val 
    290                 295                 300                 


Tyr Glu Leu Asp Ala Lys Gln Gly Arg Trp Tyr Val Val Gln Thr Asn 
305                 310                 315                 320 


Tyr Asp Arg Trp Lys His Pro Phe Phe Leu Asp Asp Arg Arg Thr Pro 
                325                 330                 335     


Ala Lys Met Cys Leu Asn Arg Thr Ser Gln Glu Asn Ile Ser Phe Glu 
            340                 345                 350         


Thr Met Tyr Asp Val Leu Ser Thr Lys Pro Val Leu Asn Lys Leu Thr 
        355                 360                 365             


Val Tyr Thr Thr Leu Ile Asp Val Thr Lys Gly Gln Phe Glu Thr Tyr 
    370                 375                 380                 


Leu Arg Asp Cys Pro Asp Pro Cys Ile Gly Trp 
385                 390                 395 


<210>  33
<211>  1035
<212>  DNA
<213>  Homo sapiens

<400>  33
atggcccaga aggagaactc ctacccctgg ccctacggcc gacagacggc tccatctggc       60

ctgagcaccc tgccccagcg agtcctccgg aaagagcctg tcaccccatc tgcacttgtc      120

ctcatgagcc gctccaatgt ccagcccaca gctgcccctg gccagaaggt gatggagaat      180

agcagtggga cacccgacat cttaacgcgg cacttcacaa ttgatgactt tgagattggg      240

cgtcctctgg gcaaaggcaa gtttggaaac gtgtacttgg ctcgggagaa gaaaagccat      300

ttcatcgtgg cgctcaaggt cctcttcaag tcccagatag agaaggaggg cgtggagcat      360

cagctgcgca gagagatcga aatccaggcc cacctgcacc atcccaacat cctgcgtctc      420

tacaactatt tttatgaccg gaggaggatc tacttgattc tagagtatgc cccccgcggg      480

gagctctaca aggagctgca gaagagctgc acatttgacg agcagcgaac agccacgatc      540

atggaggagt tggcagatgc tctaatgtac tgccatggga agaaggtgat tcacagagac      600

ataaagccag aaaatctgct cttagggctc aagggagagc tgaagattgc tgacttcggc      660

tggtctgtgc atgcgccctc cctgaggagg aagacaatgt gtggcaccct ggactacctg      720

cccccagaga tgattgaggg gcgcatgcac aatgagaagg tggatctgtg gtgcattgga      780

gtgctttgct atgagctgct ggtggggaac ccaccctttg agagtgcatc acacaacgag      840

acctatcgcc gcatcgtcaa ggtggaccta aagttccccg cttccgtgcc catgggagcc      900

caggacctca tctccaaact gctcaggcat aacccctcgg aacggctgcc cctggcccag      960

gtctcagccc acccttgggt ccgggccaac tctcggaggg tgctgcctcc ctctgccctt     1020

caatctgtcg cctga                                                      1035


<210>  34
<211>  344
<212>  PRT
<213>  Homo sapiens

<400>  34

Met Ala Gln Lys Glu Asn Ser Tyr Pro Trp Pro Tyr Gly Arg Gln Thr 
1               5                   10                  15      


Ala Pro Ser Gly Leu Ser Thr Leu Pro Gln Arg Val Leu Arg Lys Glu 
            20                  25                  30          


Pro Val Thr Pro Ser Ala Leu Val Leu Met Ser Arg Ser Asn Val Gln 
        35                  40                  45              


Pro Thr Ala Ala Pro Gly Gln Lys Val Met Glu Asn Ser Ser Gly Thr 
    50                  55                  60                  


Pro Asp Ile Leu Thr Arg His Phe Thr Ile Asp Asp Phe Glu Ile Gly 
65                  70                  75                  80  


Arg Pro Leu Gly Lys Gly Lys Phe Gly Asn Val Tyr Leu Ala Arg Glu 
                85                  90                  95      


Lys Lys Ser His Phe Ile Val Ala Leu Lys Val Leu Phe Lys Ser Gln 
            100                 105                 110         


Ile Glu Lys Glu Gly Val Glu His Gln Leu Arg Arg Glu Ile Glu Ile 
        115                 120                 125             


Gln Ala His Leu His His Pro Asn Ile Leu Arg Leu Tyr Asn Tyr Phe 
    130                 135                 140                 


Tyr Asp Arg Arg Arg Ile Tyr Leu Ile Leu Glu Tyr Ala Pro Arg Gly 
145                 150                 155                 160 


Glu Leu Tyr Lys Glu Leu Gln Lys Ser Cys Thr Phe Asp Glu Gln Arg 
                165                 170                 175     


Thr Ala Thr Ile Met Glu Glu Leu Ala Asp Ala Leu Met Tyr Cys His 
            180                 185                 190         


Gly Lys Lys Val Ile His Arg Asp Ile Lys Pro Glu Asn Leu Leu Leu 
        195                 200                 205             


Gly Leu Lys Gly Glu Leu Lys Ile Ala Asp Phe Gly Trp Ser Val His 
    210                 215                 220                 


Ala Pro Ser Leu Arg Arg Lys Thr Met Cys Gly Thr Leu Asp Tyr Leu 
225                 230                 235                 240 


Pro Pro Glu Met Ile Glu Gly Arg Met His Asn Glu Lys Val Asp Leu 
                245                 250                 255     


Trp Cys Ile Gly Val Leu Cys Tyr Glu Leu Leu Val Gly Asn Pro Pro 
            260                 265                 270         


Phe Glu Ser Ala Ser His Asn Glu Thr Tyr Arg Arg Ile Val Lys Val 
        275                 280                 285             


Asp Leu Lys Phe Pro Ala Ser Val Pro Met Gly Ala Gln Asp Leu Ile 
    290                 295                 300                 


Ser Lys Leu Leu Arg His Asn Pro Ser Glu Arg Leu Pro Leu Ala Gln 
305                 310                 315                 320 


Val Ser Ala His Pro Trp Val Arg Ala Asn Ser Arg Arg Val Leu Pro 
                325                 330                 335     


Pro Ser Ala Leu Gln Ser Val Ala 
            340                 


<210>  35
<211>  1857
<212>  DNA
<213>  Homo sapiens

<400>  35
atgcacaaaa ctgcctccca aagacttttc ccaggtccct cgtatcaaaa cattaagagt       60

ataatggaag atagcacgat cttgtcagat tggacaaaca gcaacaaaca aaaaatgaag      120

tatgactttt cctgtgaact ctacagaatg tctacatatt caactttccc cgccggggtg      180

cctgtctcag aaaggagtct tgctcgtgct ggtttttatt atactggtgt gaatgacaag      240

gtcaaatgct tctgttgtgg cctgatgctg gataactgga aactaggaga cagtcctatt      300

caaaagcata aacagctata tcctagctgt agctttattc agaatctggt ttcagctagt      360

ctgggatcca cctctaagaa tacgtctcca atgagaaaca gttttgcaca ttcattatct      420

cccaccttgg aacatagtag cttgttcagt ggttcttact ccagcctttc tccaaaccct      480

cttaattcta gagcagttga agacatctct tcatcgagga ctaaccccta cagttatgca      540

atgagtactg aagaagccag atttcttacc taccatatgt ggccattaac ttttttgtca      600

ccatcagaat tggcaagagc tggtttttat tatataggac ctggagatag ggtagcctgc      660

tttgcctgtg gtgggaagct cagtaactgg gaaccaaagg atgatgctat gtcagaacac      720

cggaggcatt ttcccaactg tccatttttg gaaaattctc tagaaactct gaggtttagc      780

atttcaaatc tgagcatgca gacacatgca gctcgaatga gaacatttat gtactggcca      840

tctagtgttc cagttcagcc tgagcagctt gcaagtgctg gtttttatta tgtgggtcgc      900

aatgatgatg tcaaatgctt ttgttgtgat ggtggcttga ggtgttggga atctggagat      960

gatccatggg tagaacatgc caagtggttt ccaaggtgtg agttcttgat acgaatgaaa     1020

ggccaagagt ttgttgatga gattcaaggt agatatcctc atcttcttga acagctgttg     1080

tcaacttcag ataccactgg agaagaaaat gctgacccac caattattca ttttggacct     1140

ggagaaagtt cttcagaaga tgctgtcatg atgaatacac ctgtggttaa atctgccttg     1200

gaaatgggct ttaatagaga cctggtgaaa caaacagttc aaagtaaaat cctgacaact     1260

ggagagaact ataaaacagt taatgatatt gtgtcagcac ttcttaatgc tgaagatgaa     1320

aaaagagaag aggagaagga aaaacaagct gaagaaatgg catcagatga tttgtcatta     1380

attcggaaga acagaatggc tctctttcaa caattgacat gtgtgcttcc tatcctggat     1440

aatcttttaa aggccaatgt aattaataaa caggaacatg atattattaa acaaaaaaca     1500

cagatacctt tacaagcgag agaactgatt gataccattt tggttaaagg aaatgctgcg     1560

gccaacatct tcaaaaactg tctaaaagaa attgactcta cattgtataa gaacttattt     1620

gtggataaga atatgaagta tattccaaca gaagatgttt caggtctgtc actggaagaa     1680

caattgagga ggttgcaaga agaacgaact tgtaaagtgt gtatggacaa agaagtttct     1740

gttgtattta ttccttgtgg tcatctggta gtatgccagg aatgtgcccc ttctctaaga     1800

aaatgcccta tttgcagggg tataatcaag ggtactgttc gtacatttct ctcttaa        1857


<210>  36
<211>  618
<212>  PRT
<213>  Homo sapiens

<400>  36

Met His Lys Thr Ala Ser Gln Arg Leu Phe Pro Gly Pro Ser Tyr Gln 
1               5                   10                  15      


Asn Ile Lys Ser Ile Met Glu Asp Ser Thr Ile Leu Ser Asp Trp Thr 
            20                  25                  30          


Asn Ser Asn Lys Gln Lys Met Lys Tyr Asp Phe Ser Cys Glu Leu Tyr 
        35                  40                  45              


Arg Met Ser Thr Tyr Ser Thr Phe Pro Ala Gly Val Pro Val Ser Glu 
    50                  55                  60                  


Arg Ser Leu Ala Arg Ala Gly Phe Tyr Tyr Thr Gly Val Asn Asp Lys 
65                  70                  75                  80  


Val Lys Cys Phe Cys Cys Gly Leu Met Leu Asp Asn Trp Lys Leu Gly 
                85                  90                  95      


Asp Ser Pro Ile Gln Lys His Lys Gln Leu Tyr Pro Ser Cys Ser Phe 
            100                 105                 110         


Ile Gln Asn Leu Val Ser Ala Ser Leu Gly Ser Thr Ser Lys Asn Thr 
        115                 120                 125             


Ser Pro Met Arg Asn Ser Phe Ala His Ser Leu Ser Pro Thr Leu Glu 
    130                 135                 140                 


His Ser Ser Leu Phe Ser Gly Ser Tyr Ser Ser Leu Ser Pro Asn Pro 
145                 150                 155                 160 


Leu Asn Ser Arg Ala Val Glu Asp Ile Ser Ser Ser Arg Thr Asn Pro 
                165                 170                 175     


Tyr Ser Tyr Ala Met Ser Thr Glu Glu Ala Arg Phe Leu Thr Tyr His 
            180                 185                 190         


Met Trp Pro Leu Thr Phe Leu Ser Pro Ser Glu Leu Ala Arg Ala Gly 
        195                 200                 205             


Phe Tyr Tyr Ile Gly Pro Gly Asp Arg Val Ala Cys Phe Ala Cys Gly 
    210                 215                 220                 


Gly Lys Leu Ser Asn Trp Glu Pro Lys Asp Asp Ala Met Ser Glu His 
225                 230                 235                 240 


Arg Arg His Phe Pro Asn Cys Pro Phe Leu Glu Asn Ser Leu Glu Thr 
                245                 250                 255     


Leu Arg Phe Ser Ile Ser Asn Leu Ser Met Gln Thr His Ala Ala Arg 
            260                 265                 270         


Met Arg Thr Phe Met Tyr Trp Pro Ser Ser Val Pro Val Gln Pro Glu 
        275                 280                 285             


Gln Leu Ala Ser Ala Gly Phe Tyr Tyr Val Gly Arg Asn Asp Asp Val 
    290                 295                 300                 


Lys Cys Phe Cys Cys Asp Gly Gly Leu Arg Cys Trp Glu Ser Gly Asp 
305                 310                 315                 320 


Asp Pro Trp Val Glu His Ala Lys Trp Phe Pro Arg Cys Glu Phe Leu 
                325                 330                 335     


Ile Arg Met Lys Gly Gln Glu Phe Val Asp Glu Ile Gln Gly Arg Tyr 
            340                 345                 350         


Pro His Leu Leu Glu Gln Leu Leu Ser Thr Ser Asp Thr Thr Gly Glu 
        355                 360                 365             


Glu Asn Ala Asp Pro Pro Ile Ile His Phe Gly Pro Gly Glu Ser Ser 
    370                 375                 380                 


Ser Glu Asp Ala Val Met Met Asn Thr Pro Val Val Lys Ser Ala Leu 
385                 390                 395                 400 


Glu Met Gly Phe Asn Arg Asp Leu Val Lys Gln Thr Val Gln Ser Lys 
                405                 410                 415     


Ile Leu Thr Thr Gly Glu Asn Tyr Lys Thr Val Asn Asp Ile Val Ser 
            420                 425                 430         


Ala Leu Leu Asn Ala Glu Asp Glu Lys Arg Glu Glu Glu Lys Glu Lys 
        435                 440                 445             


Gln Ala Glu Glu Met Ala Ser Asp Asp Leu Ser Leu Ile Arg Lys Asn 
    450                 455                 460                 


Arg Met Ala Leu Phe Gln Gln Leu Thr Cys Val Leu Pro Ile Leu Asp 
465                 470                 475                 480 


Asn Leu Leu Lys Ala Asn Val Ile Asn Lys Gln Glu His Asp Ile Ile 
                485                 490                 495     


Lys Gln Lys Thr Gln Ile Pro Leu Gln Ala Arg Glu Leu Ile Asp Thr 
            500                 505                 510         


Ile Leu Val Lys Gly Asn Ala Ala Ala Asn Ile Phe Lys Asn Cys Leu 
        515                 520                 525             


Lys Glu Ile Asp Ser Thr Leu Tyr Lys Asn Leu Phe Val Asp Lys Asn 
    530                 535                 540                 


Met Lys Tyr Ile Pro Thr Glu Asp Val Ser Gly Leu Ser Leu Glu Glu 
545                 550                 555                 560 


Gln Leu Arg Arg Leu Gln Glu Glu Arg Thr Cys Lys Val Cys Met Asp 
                565                 570                 575     


Lys Glu Val Ser Val Val Phe Ile Pro Cys Gly His Leu Val Val Cys 
            580                 585                 590         


Gln Glu Cys Ala Pro Ser Leu Arg Lys Cys Pro Ile Cys Arg Gly Ile 
        595                 600                 605             


Ile Lys Gly Thr Val Arg Thr Phe Leu Ser 
    610                 615             


<210>  37
<211>  906
<212>  DNA
<213>  Homo sapiens

<400>  37
atggaaggag acttctcggt gtgcaggaac tgtaaaagac atgtagtctc tgccaacttc       60

accctccatg aggcttactg cctgcggttc ctggtcctgt gtccggagtg tgaggagcct      120

gtccccaagg aaaccatgga ggagcactgc aagcttgagc accagcaggt tgggtgtacg      180

atgtgtcagc agagcatgca gaagtcctcg ctggagtttc ataaggccaa tgagtgccag      240

gagcgccctg ttgagtgtaa gttctgcaaa ctggacatgc agctcagcaa gctggagctc      300

cacgagtcct actgtggcag ccggacagag ctctgccaag gctgtggcca gttcatcatg      360

caccgcatgc tcgcccagca cagagatgtc tgtcgcagtg aacaggccca gctcgggaaa      420

ggggaaagaa tttcagctcc tgaaagggaa atctactgtc attattgcaa ccaaatgatt      480

ccagaaaata agtatttcca ccatatgggt aaatgttgtc cagactcaga gtttaagaaa      540

cactttcctg ttggaaatcc agaaattctt ccttcatctc ttccaagtca agctgctgaa      600

aatcaaactt ccacgatgga gaaagatgtt cgtccaaaga caagaagtat aaacagattt      660

cctcttcatt ctgaaagttc atcaaagaaa gcaccaagaa gcaaaaacaa aaccttggat      720

ccacttttga tgtcagagcc caagcccagg accagctccc ctagaggaga taaagcagcc      780

tatgacattc tgaggagatg ttctcagtgt ggcatcctgc ttcccctgcc gatcctaaat      840

caacatcagg agaaatgccg gtggttagct tcatcaaaag gaaaacaagt gagaaatttc      900

agctag                                                                 906


<210>  38
<211>  301
<212>  PRT
<213>  Homo sapiens

<400>  38

Met Glu Gly Asp Phe Ser Val Cys Arg Asn Cys Lys Arg His Val Val 
1               5                   10                  15      


Ser Ala Asn Phe Thr Leu His Glu Ala Tyr Cys Leu Arg Phe Leu Val 
            20                  25                  30          


Leu Cys Pro Glu Cys Glu Glu Pro Val Pro Lys Glu Thr Met Glu Glu 
        35                  40                  45              


His Cys Lys Leu Glu His Gln Gln Val Gly Cys Thr Met Cys Gln Gln 
    50                  55                  60                  


Ser Met Gln Lys Ser Ser Leu Glu Phe His Lys Ala Asn Glu Cys Gln 
65                  70                  75                  80  


Glu Arg Pro Val Glu Cys Lys Phe Cys Lys Leu Asp Met Gln Leu Ser 
                85                  90                  95      


Lys Leu Glu Leu His Glu Ser Tyr Cys Gly Ser Arg Thr Glu Leu Cys 
            100                 105                 110         


Gln Gly Cys Gly Gln Phe Ile Met His Arg Met Leu Ala Gln His Arg 
        115                 120                 125             


Asp Val Cys Arg Ser Glu Gln Ala Gln Leu Gly Lys Gly Glu Arg Ile 
    130                 135                 140                 


Ser Ala Pro Glu Arg Glu Ile Tyr Cys His Tyr Cys Asn Gln Met Ile 
145                 150                 155                 160 


Pro Glu Asn Lys Tyr Phe His His Met Gly Lys Cys Cys Pro Asp Ser 
                165                 170                 175     


Glu Phe Lys Lys His Phe Pro Val Gly Asn Pro Glu Ile Leu Pro Ser 
            180                 185                 190         


Ser Leu Pro Ser Gln Ala Ala Glu Asn Gln Thr Ser Thr Met Glu Lys 
        195                 200                 205             


Asp Val Arg Pro Lys Thr Arg Ser Ile Asn Arg Phe Pro Leu His Ser 
    210                 215                 220                 


Glu Ser Ser Ser Lys Lys Ala Pro Arg Ser Lys Asn Lys Thr Leu Asp 
225                 230                 235                 240 


Pro Leu Leu Met Ser Glu Pro Lys Pro Arg Thr Ser Ser Pro Arg Gly 
                245                 250                 255     


Asp Lys Ala Ala Tyr Asp Ile Leu Arg Arg Cys Ser Gln Cys Gly Ile 
            260                 265                 270         


Leu Leu Pro Leu Pro Ile Leu Asn Gln His Gln Glu Lys Cys Arg Trp 
        275                 280                 285             


Leu Ala Ser Ser Lys Gly Lys Gln Val Arg Asn Phe Ser 
    290                 295                 300     


<210>  39
<211>  1725
<212>  DNA
<213>  Homo sapiens

<400>  39
atgcctcctc agcttcaaga aactagaatg aaccgaagca ttcctgtgga ggttgatgaa       60

tcagaaccat acccaagtca gttgctgaaa ccaatcccag aatattcccc ggaagaggaa      120

tcagaaccac ctgctccaaa tataaggaac atggcaccca acagcttgtc tgcacccaca      180

atgcttcaca attcctccgg agacttttct caagctcact caaccctgaa acttgcaaat      240

caccagcggc ctgtatcccg gcaggtcacc tgcctgcgca ctcaagttct ggaggacagt      300

gaagacagtt tctgcaggag acacccaggc ctgggcaaag ctttcccttc tgggtgctct      360

gcagtcagcg agcctgcgtc tgagtctgtg gttggagccc tccctgcaga gcatcagttt      420

tcatttatgg aaaaacgtaa tcaatggctg gtatctcagc tttcagcggc ttctcctgac      480

actggccatg actcagacaa atcagaccaa agtttaccta atgcctcagc agactccttg      540

ggcggtagcc aggagatggt gcaacggccc cagcctcaca ggaaccgagc aggcctggat      600

ctgccaacca tagacacggg atatgattcc cagccccagg atgtcctggg catcaggcag      660

ctggaaaggc ccctgcccct cacctccgtg tgttaccccc aggacctccc cagacctctc      720

aggtccaggg agttccctca gtttgaacct cagaggtatc cagcatgtgc acagatgctg      780

cctcccaatc tttccccaca tgctccatgg aactatcatt accattgtcc tggaagtccc      840

gatcaccagg tgccatatgg ccatgactac cctcgagcag cctaccagca agtgatccag      900

ccggctctgc ctgggcagcc cctgcctgga gccagtgtga gaggcctgca ccctgtgcag      960

aaggttatcc tgaattatcc cagcccctgg gaccacgaag agaggcccgc acagagagac     1020

tgctcctttc cggggcttcc aaggcaccag gaccagccac atcaccagcc acctaataga     1080

gctggtgctc ctggggagtc cttggagtgc cctgcagagc tgagaccaca ggttccccag     1140

cctccgtccc cagctgctgt gcctagaccc cctagcaacc ctccagccag aggaactcta     1200

aaaacaagca atttgccaga agaattgcgg aaagtcttta tcacttattc gatggacaca     1260

gctatggagg tggtgaaatt cgtgaacttt ttgttggtaa atggcttcca aactgcaatt     1320

gacatatttg aggatagaat ccgaggcatt gatatcatta aatggatgga gcgctacctt     1380

agggataaga ccgtgatgat aatcgtagca atcagcccca aatacaaaca ggacgtggaa     1440

ggcgctgagt cgcagctgga cgaggatgag catggcttac atactaagta cattcatcga     1500

atgatgcaga ttgagttcat aaaacaagga agcatgaatt tcagattcat ccctgtgctc     1560

ttcccaaatg ctaagaagga gcatgtgccc acctggcttc agaacactca tgtctacagc     1620

tggcccaaga ataaaaaaaa catcctgctg cggctgctga gagaggaaga gtatgtggct     1680

cctccacggg ggcctctgcc cacccttcag gtggttccct tgtga                     1725


<210>  40
<211>  574
<212>  PRT
<213>  Homo sapiens

<400>  40

Met Pro Pro Gln Leu Gln Glu Thr Arg Met Asn Arg Ser Ile Pro Val 
1               5                   10                  15      


Glu Val Asp Glu Ser Glu Pro Tyr Pro Ser Gln Leu Leu Lys Pro Ile 
            20                  25                  30          


Pro Glu Tyr Ser Pro Glu Glu Glu Ser Glu Pro Pro Ala Pro Asn Ile 
        35                  40                  45              


Arg Asn Met Ala Pro Asn Ser Leu Ser Ala Pro Thr Met Leu His Asn 
    50                  55                  60                  


Ser Ser Gly Asp Phe Ser Gln Ala His Ser Thr Leu Lys Leu Ala Asn 
65                  70                  75                  80  


His Gln Arg Pro Val Ser Arg Gln Val Thr Cys Leu Arg Thr Gln Val 
                85                  90                  95      


Leu Glu Asp Ser Glu Asp Ser Phe Cys Arg Arg His Pro Gly Leu Gly 
            100                 105                 110         


Lys Ala Phe Pro Ser Gly Cys Ser Ala Val Ser Glu Pro Ala Ser Glu 
        115                 120                 125             


Ser Val Val Gly Ala Leu Pro Ala Glu His Gln Phe Ser Phe Met Glu 
    130                 135                 140                 


Lys Arg Asn Gln Trp Leu Val Ser Gln Leu Ser Ala Ala Ser Pro Asp 
145                 150                 155                 160 


Thr Gly His Asp Ser Asp Lys Ser Asp Gln Ser Leu Pro Asn Ala Ser 
                165                 170                 175     


Ala Asp Ser Leu Gly Gly Ser Gln Glu Met Val Gln Arg Pro Gln Pro 
            180                 185                 190         


His Arg Asn Arg Ala Gly Leu Asp Leu Pro Thr Ile Asp Thr Gly Tyr 
        195                 200                 205             


Asp Ser Gln Pro Gln Asp Val Leu Gly Ile Arg Gln Leu Glu Arg Pro 
    210                 215                 220                 


Leu Pro Leu Thr Ser Val Cys Tyr Pro Gln Asp Leu Pro Arg Pro Leu 
225                 230                 235                 240 


Arg Ser Arg Glu Phe Pro Gln Phe Glu Pro Gln Arg Tyr Pro Ala Cys 
                245                 250                 255     


Ala Gln Met Leu Pro Pro Asn Leu Ser Pro His Ala Pro Trp Asn Tyr 
            260                 265                 270         


His Tyr His Cys Pro Gly Ser Pro Asp His Gln Val Pro Tyr Gly His 
        275                 280                 285             


Asp Tyr Pro Arg Ala Ala Tyr Gln Gln Val Ile Gln Pro Ala Leu Pro 
    290                 295                 300                 


Gly Gln Pro Leu Pro Gly Ala Ser Val Arg Gly Leu His Pro Val Gln 
305                 310                 315                 320 


Lys Val Ile Leu Asn Tyr Pro Ser Pro Trp Asp His Glu Glu Arg Pro 
                325                 330                 335     


Ala Gln Arg Asp Cys Ser Phe Pro Gly Leu Pro Arg His Gln Asp Gln 
            340                 345                 350         


Pro His His Gln Pro Pro Asn Arg Ala Gly Ala Pro Gly Glu Ser Leu 
        355                 360                 365             


Glu Cys Pro Ala Glu Leu Arg Pro Gln Val Pro Gln Pro Pro Ser Pro 
    370                 375                 380                 


Ala Ala Val Pro Arg Pro Pro Ser Asn Pro Pro Ala Arg Gly Thr Leu 
385                 390                 395                 400 


Lys Thr Ser Asn Leu Pro Glu Glu Leu Arg Lys Val Phe Ile Thr Tyr 
                405                 410                 415     


Ser Met Asp Thr Ala Met Glu Val Val Lys Phe Val Asn Phe Leu Leu 
            420                 425                 430         


Val Asn Gly Phe Gln Thr Ala Ile Asp Ile Phe Glu Asp Arg Ile Arg 
        435                 440                 445             


Gly Ile Asp Ile Ile Lys Trp Met Glu Arg Tyr Leu Arg Asp Lys Thr 
    450                 455                 460                 


Val Met Ile Ile Val Ala Ile Ser Pro Lys Tyr Lys Gln Asp Val Glu 
465                 470                 475                 480 


Gly Ala Glu Ser Gln Leu Asp Glu Asp Glu His Gly Leu His Thr Lys 
                485                 490                 495     


Tyr Ile His Arg Met Met Gln Ile Glu Phe Ile Lys Gln Gly Ser Met 
            500                 505                 510         


Asn Phe Arg Phe Ile Pro Val Leu Phe Pro Asn Ala Lys Lys Glu His 
        515                 520                 525             


Val Pro Thr Trp Leu Gln Asn Thr His Val Tyr Ser Trp Pro Lys Asn 
    530                 535                 540                 


Lys Lys Asn Ile Leu Leu Arg Leu Leu Arg Glu Glu Glu Tyr Val Ala 
545                 550                 555                 560 


Pro Pro Arg Gly Pro Leu Pro Thr Leu Gln Val Val Pro Leu 
                565                 570                 


<210>  41
<211>  2382
<212>  DNA
<213>  Homo sapiens

<400>  41
atggatgatt ttgagcgtcg cagagaactt agaaggcaaa agagggagga gatgcgactc       60

gaagcagaaa gaatcgccta ccagaggaat gacgatgatg aagaggaggc agcccgggaa      120

cgccgccgcc gagcccgaca ggaacggctg cggcagaagc aggaggaaga atccttggga      180

caggtgaccg accaggtgga ggtgaatgcc cagaacagtg tgcctgacga ggaggccaag      240

acaaccacca caaacactca agtggaaggg gatgatgagg ccgcattcct ggagcgcctg      300

gctcggcgtg aggaaagacg ccaaaaacgc cttcaggagg ctctggagcg gcagaaggag      360

ttcgacccaa caataacaga tgcaagtctg tcgctcccaa gcagaagaat gcaaaatgac      420

acagcagaaa atgaaactac cgagaaggaa gaaaaaagtg aaagtcgcca agaaagatac      480

gagatagagg aaacagaaac agtcaccaag tcctaccaga agaatgattg gagggatgct      540

gaagaaaaca agaaagaaga caaggaaaag gaggaggagg aagaggagaa gccaaagcga      600

gggagcattg gagaaaatca ggtagaggtg atggtggaag agaaaacaac tgaaagccag      660

gaggaaacag tggtaatgtc attaaaaaat gggcagatca gttcagaaga gcctaaacaa      720

gaggaggaga gggaacaagg ttcagatgag atttcccatc atgaaaagat ggaagaggaa      780

gacaaggaaa gagctgaggc agagagggca aggttggaag cagaagaaag agaaagaatt      840

aaagccgagc aagacaaaaa gatagcagat gaacgagcaa gaattgaagc agaagaaaaa      900

gcagctgccc aagaaagaga aaggagagag gcagaagaga gggaaaggat gagggaggaa      960

gagaaaaggg cagcagagga gaggcagagg ataaaggagg aagagaaaag ggcagcagag     1020

gagaggcaga ggataaagga ggaagagaaa agggcagcag aggagaggca gaggataaaa     1080

gaggaagaga aaagggcagc agaggagagg caaagggcca gggcagagga ggaagagaag     1140

gctaaggtag aagagcagaa acgtaacaag cagctagaag agaaaaaacg tgccatgcaa     1200

gagacaaaga taaaagggga aaaggtagaa cagaaaatag aagggaaatg ggtaaatgaa     1260

aagaaagcac aagaagataa acttcagaca gctgtcctaa agaaacaggg agaagagaag     1320

ggaactaaag tgcaagctaa aagagaaaag ctccaagaag acaagcctac cttcaaaaaa     1380

gaagagatca aagatgaaaa gattaaaaag gacaaagaac ccaaagaaga agttaagagc     1440

ttcatggatc gaaagaaggg atttacagaa gttaagtcgc agaatggaga attcatgacc     1500

cacaaactta aacatactga gaatactttc agccgccctg gagggagggc cagcgtggac     1560

accaaggagg ctgagggcgc cccccaggtg gaagccggca aaaggctgga ggagcttcgt     1620

cgtcgtcgcg gggagaccga gagcgaagag ttcgagaagc tcaaacagaa gcagcaggag     1680

gcggctttgg agctggagga actcaagaaa aagagggagg agagaaggaa ggtcctggag     1740

gaggaagagc agaggaggaa gcaggaggaa gccgatcgaa aactcagaga ggaggaagag     1800

aagaggaggc taaaggaaga gattgaaagg cgaagagcag aagctgctga gaaacgccag     1860

aagatgccag aagatggctt gtcagatgac aagaaaccat tcaagtgttt cactcctaaa     1920

ggttcatctc tcaagataga agagcgagca gaatttttga ataagtctgt gcagaaaagc     1980

agtggtgtca aatcgaccca tcaagcagca atagtctcca agattgacag cagactggag     2040

cagtatacca gtgcaattga gggaacaaaa agcgcaaaac ctacaaagcc ggcagcctcg     2100

gatcttcctg ttcctgctga aggtgtacgc aacatcaaga gtatgtggga gaaagggaat     2160

gtgttttcat cccccactgc agcaggcaca ccaaataagg aaactgctgg cttgaaggta     2220

ggggtttcta gccgcatcaa tgaatggcta actaaaaccc cagatggaaa caagtcacct     2280

gctcccaaac cttctgactt gagaccagga gacgtatcca gcaagcggaa cctctgggaa     2340

aagcaatctg tggataaggt cacttccccc actaaggttt ga                        2382


<210>  42
<211>  793
<212>  PRT
<213>  Homo sapiens

<400>  42

Met Asp Asp Phe Glu Arg Arg Arg Glu Leu Arg Arg Gln Lys Arg Glu 
1               5                   10                  15      


Glu Met Arg Leu Glu Ala Glu Arg Ile Ala Tyr Gln Arg Asn Asp Asp 
            20                  25                  30          


Asp Glu Glu Glu Ala Ala Arg Glu Arg Arg Arg Arg Ala Arg Gln Glu 
        35                  40                  45              


Arg Leu Arg Gln Lys Gln Glu Glu Glu Ser Leu Gly Gln Val Thr Asp 
    50                  55                  60                  


Gln Val Glu Val Asn Ala Gln Asn Ser Val Pro Asp Glu Glu Ala Lys 
65                  70                  75                  80  


Thr Thr Thr Thr Asn Thr Gln Val Glu Gly Asp Asp Glu Ala Ala Phe 
                85                  90                  95      


Leu Glu Arg Leu Ala Arg Arg Glu Glu Arg Arg Gln Lys Arg Leu Gln 
            100                 105                 110         


Glu Ala Leu Glu Arg Gln Lys Glu Phe Asp Pro Thr Ile Thr Asp Ala 
        115                 120                 125             


Ser Leu Ser Leu Pro Ser Arg Arg Met Gln Asn Asp Thr Ala Glu Asn 
    130                 135                 140                 


Glu Thr Thr Glu Lys Glu Glu Lys Ser Glu Ser Arg Gln Glu Arg Tyr 
145                 150                 155                 160 


Glu Ile Glu Glu Thr Glu Thr Val Thr Lys Ser Tyr Gln Lys Asn Asp 
                165                 170                 175     


Trp Arg Asp Ala Glu Glu Asn Lys Lys Glu Asp Lys Glu Lys Glu Glu 
            180                 185                 190         


Glu Glu Glu Glu Lys Pro Lys Arg Gly Ser Ile Gly Glu Asn Gln Val 
        195                 200                 205             


Glu Val Met Val Glu Glu Lys Thr Thr Glu Ser Gln Glu Glu Thr Val 
    210                 215                 220                 


Val Met Ser Leu Lys Asn Gly Gln Ile Ser Ser Glu Glu Pro Lys Gln 
225                 230                 235                 240 


Glu Glu Glu Arg Glu Gln Gly Ser Asp Glu Ile Ser His His Glu Lys 
                245                 250                 255     


Met Glu Glu Glu Asp Lys Glu Arg Ala Glu Ala Glu Arg Ala Arg Leu 
            260                 265                 270         


Glu Ala Glu Glu Arg Glu Arg Ile Lys Ala Glu Gln Asp Lys Lys Ile 
        275                 280                 285             


Ala Asp Glu Arg Ala Arg Ile Glu Ala Glu Glu Lys Ala Ala Ala Gln 
    290                 295                 300                 


Glu Arg Glu Arg Arg Glu Ala Glu Glu Arg Glu Arg Met Arg Glu Glu 
305                 310                 315                 320 


Glu Lys Arg Ala Ala Glu Glu Arg Gln Arg Ile Lys Glu Glu Glu Lys 
                325                 330                 335     


Arg Ala Ala Glu Glu Arg Gln Arg Ile Lys Glu Glu Glu Lys Arg Ala 
            340                 345                 350         


Ala Glu Glu Arg Gln Arg Ile Lys Glu Glu Glu Lys Arg Ala Ala Glu 
        355                 360                 365             


Glu Arg Gln Arg Ala Arg Ala Glu Glu Glu Glu Lys Ala Lys Val Glu 
    370                 375                 380                 


Glu Gln Lys Arg Asn Lys Gln Leu Glu Glu Lys Lys Arg Ala Met Gln 
385                 390                 395                 400 


Glu Thr Lys Ile Lys Gly Glu Lys Val Glu Gln Lys Ile Glu Gly Lys 
                405                 410                 415     


Trp Val Asn Glu Lys Lys Ala Gln Glu Asp Lys Leu Gln Thr Ala Val 
            420                 425                 430         


Leu Lys Lys Gln Gly Glu Glu Lys Gly Thr Lys Val Gln Ala Lys Arg 
        435                 440                 445             


Glu Lys Leu Gln Glu Asp Lys Pro Thr Phe Lys Lys Glu Glu Ile Lys 
    450                 455                 460                 


Asp Glu Lys Ile Lys Lys Asp Lys Glu Pro Lys Glu Glu Val Lys Ser 
465                 470                 475                 480 


Phe Met Asp Arg Lys Lys Gly Phe Thr Glu Val Lys Ser Gln Asn Gly 
                485                 490                 495     


Glu Phe Met Thr His Lys Leu Lys His Thr Glu Asn Thr Phe Ser Arg 
            500                 505                 510         


Pro Gly Gly Arg Ala Ser Val Asp Thr Lys Glu Ala Glu Gly Ala Pro 
        515                 520                 525             


Gln Val Glu Ala Gly Lys Arg Leu Glu Glu Leu Arg Arg Arg Arg Gly 
    530                 535                 540                 


Glu Thr Glu Ser Glu Glu Phe Glu Lys Leu Lys Gln Lys Gln Gln Glu 
545                 550                 555                 560 


Ala Ala Leu Glu Leu Glu Glu Leu Lys Lys Lys Arg Glu Glu Arg Arg 
                565                 570                 575     


Lys Val Leu Glu Glu Glu Glu Gln Arg Arg Lys Gln Glu Glu Ala Asp 
            580                 585                 590         


Arg Lys Leu Arg Glu Glu Glu Glu Lys Arg Arg Leu Lys Glu Glu Ile 
        595                 600                 605             


Glu Arg Arg Arg Ala Glu Ala Ala Glu Lys Arg Gln Lys Met Pro Glu 
    610                 615                 620                 


Asp Gly Leu Ser Asp Asp Lys Lys Pro Phe Lys Cys Phe Thr Pro Lys 
625                 630                 635                 640 


Gly Ser Ser Leu Lys Ile Glu Glu Arg Ala Glu Phe Leu Asn Lys Ser 
                645                 650                 655     


Val Gln Lys Ser Ser Gly Val Lys Ser Thr His Gln Ala Ala Ile Val 
            660                 665                 670         


Ser Lys Ile Asp Ser Arg Leu Glu Gln Tyr Thr Ser Ala Ile Glu Gly 
        675                 680                 685             


Thr Lys Ser Ala Lys Pro Thr Lys Pro Ala Ala Ser Asp Leu Pro Val 
    690                 695                 700                 


Pro Ala Glu Gly Val Arg Asn Ile Lys Ser Met Trp Glu Lys Gly Asn 
705                 710                 715                 720 


Val Phe Ser Ser Pro Thr Ala Ala Gly Thr Pro Asn Lys Glu Thr Ala 
                725                 730                 735     


Gly Leu Lys Val Gly Val Ser Ser Arg Ile Asn Glu Trp Leu Thr Lys 
            740                 745                 750         


Thr Pro Asp Gly Asn Lys Ser Pro Ala Pro Lys Pro Ser Asp Leu Arg 
        755                 760                 765             


Pro Gly Asp Val Ser Ser Lys Arg Asn Leu Trp Glu Lys Gln Ser Val 
    770                 775                 780                 


Asp Lys Val Thr Ser Pro Thr Lys Val 
785                 790             


<210>  43
<211>  1584
<212>  DNA
<213>  Homo sapiens

<400>  43
atggccacca ccgccacctg cacccgtttc accgacgact accagctctt cgaggagctt       60

ggcaagggtg ctttctctgt ggtccgcagg tgtgtgaaga aaacctccac gcaggagtac      120

gcagcaaaaa tcatcaatac caagaagttg tctgcccggg atcaccagaa actagaacgt      180

gaggctcgga tatgtcgact tctgaaacat ccaaacatcg tgcgcctcca tgacagtatt      240

tctgaagaag ggtttcacta cctcgtgttt gaccttgtta ccggcgggga gctgtttgaa      300

gacattgtgg ccagagagta ctacagtgaa gcagatgcca gccactgtat acatcagatt      360

ctggagagtg ttaaccacat ccaccagcat gacatcgtcc acagggacct gaagcctgag      420

aacctgctgc tggcgagtaa atgcaagggt gccgccgtca agctggctga ttttggccta      480

gccatcgaag tacagggaga gcagcaggct tggtttggtt ttgctggcac cccaggttac      540

ttgtcccctg aggtcttgag gaaagatccc tatggaaaac ctgtggatat ctgggcctgc      600

ggggtcatcc tgtatatcct cctggtgggc tatcctccct tctgggatga ggatcagcac      660

aagctgtatc agcagatcaa ggctggagcc tatgatttcc catcaccaga atgggacacg      720

gtaactcctg aagccaagaa cttgatcaac cagatgctga ccataaaccc agcaaagcgc      780

atcacggctg accaggctct caagcacccg tgggtctgtc aacgatccac ggtggcatcc      840

atgatgcatc gtcaggagac tgtggagtgt ttgcgcaagt tcaatgcccg gagaaaactg      900

aagggtgcca tcctcacgac catgcttgtc tccaggaact tctcagttgg caggcagagc      960

tccgcccccg cctcgcctgc cgcgagcgcc gccggcctgg ccgggcaagc tgccaaaagc     1020

ctattgaaca agaagtcgga tggcggtgtc aagaaaagga agtcgagttc cagcgtgcac     1080

ctaatggagc cacaaaccac tgtggtacac aacgctacag atgggatcaa gggctccaca     1140

gagagctgca acaccaccac agaagatgag gacctcaaag tgcgaaaaca ggagatcatt     1200

aagattacag aacagctgat tgaagccatc aacaatgggg actttgaggc ctacacgaag     1260

atttgtgatc caggcctcac ttcctttgag cctgaggccc ttggtaacct cgtggagggg     1320

atggatttcc ataagtttta ctttgagaat ctcctgtcca agaacagcaa gcctatccat     1380

accaccatcc taaacccaca cgtccacgtg attggggagg acgcagcgtg catcgcctac     1440

atccgcctca cccagtacat cgacgggcag ggtcggcctc gcaccagcca gtcagaagag     1500

acccgggtct ggcaccgtcg ggatggcaag tggctcaatg tccactatca ctgctcaggg     1560

gcccctgccg caccgctgca gtga                                            1584


<210>  44
<211>  527
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Ala Thr Thr Ala Thr Cys Thr Arg Phe Thr Asp Asp Tyr Gln Leu 
1               5                   10                  15      


Phe Glu Glu Leu Gly Lys Gly Ala Phe Ser Val Val Arg Arg Cys Val 
            20                  25                  30          


Lys Lys Thr Ser Thr Gln Glu Tyr Ala Ala Lys Ile Ile Asn Thr Lys 
        35                  40                  45              


Lys Leu Ser Ala Arg Asp His Gln Lys Leu Glu Arg Glu Ala Arg Ile 
    50                  55                  60                  


Cys Arg Leu Leu Lys His Pro Asn Ile Val Arg Leu His Asp Ser Ile 
65                  70                  75                  80  


Ser Glu Glu Gly Phe His Tyr Leu Val Phe Asp Leu Val Thr Gly Gly 
                85                  90                  95      


Glu Leu Phe Glu Asp Ile Val Ala Arg Glu Tyr Tyr Ser Glu Ala Asp 
            100                 105                 110         


Ala Ser His Cys Ile His Gln Ile Leu Glu Ser Val Asn His Ile His 
        115                 120                 125             


Gln His Asp Ile Val His Arg Asp Leu Lys Pro Glu Asn Leu Leu Leu 
    130                 135                 140                 


Ala Ser Lys Cys Lys Gly Ala Ala Val Lys Leu Ala Asp Phe Gly Leu 
145                 150                 155                 160 


Ala Ile Glu Val Gln Gly Glu Gln Gln Ala Trp Phe Gly Phe Ala Gly 
                165                 170                 175     


Thr Pro Gly Tyr Leu Ser Pro Glu Val Leu Arg Lys Asp Pro Tyr Gly 
            180                 185                 190         


Lys Pro Val Asp Ile Trp Ala Cys Gly Val Ile Leu Tyr Ile Leu Leu 
        195                 200                 205             


Val Gly Tyr Pro Pro Phe Trp Asp Glu Asp Gln His Lys Leu Tyr Gln 
    210                 215                 220                 


Gln Ile Lys Ala Gly Ala Tyr Asp Phe Pro Ser Pro Glu Trp Asp Thr 
225                 230                 235                 240 


Val Thr Pro Glu Ala Lys Asn Leu Ile Asn Gln Met Leu Thr Ile Asn 
                245                 250                 255     


Pro Ala Lys Arg Ile Thr Ala Asp Gln Ala Leu Lys His Pro Trp Val 
            260                 265                 270         


Cys Gln Arg Ser Thr Val Ala Ser Met Met His Arg Gln Glu Thr Val 
        275                 280                 285             


Glu Cys Leu Arg Lys Phe Asn Ala Arg Arg Lys Leu Lys Gly Ala Ile 
    290                 295                 300                 


Leu Thr Thr Met Leu Val Ser Arg Asn Phe Ser Val Gly Arg Gln Ser 
305                 310                 315                 320 


Ser Ala Pro Ala Ser Pro Ala Ala Ser Ala Ala Gly Leu Ala Gly Gln 
                325                 330                 335     


Ala Ala Lys Ser Leu Leu Asn Lys Lys Ser Asp Gly Gly Val Lys Lys 
            340                 345                 350         


Arg Lys Ser Ser Ser Ser Val His Leu Met Glu Pro Gln Thr Thr Val 
        355                 360                 365             


Val His Asn Ala Thr Asp Gly Ile Lys Gly Ser Thr Glu Ser Cys Asn 
    370                 375                 380                 


Thr Thr Thr Glu Asp Glu Asp Leu Lys Val Arg Lys Gln Glu Ile Ile 
385                 390                 395                 400 


Lys Ile Thr Glu Gln Leu Ile Glu Ala Ile Asn Asn Gly Asp Phe Glu 
                405                 410                 415     


Ala Tyr Thr Lys Ile Cys Asp Pro Gly Leu Thr Ser Phe Glu Pro Glu 
            420                 425                 430         


Ala Leu Gly Asn Leu Val Glu Gly Met Asp Phe His Lys Phe Tyr Phe 
        435                 440                 445             


Glu Asn Leu Leu Ser Lys Asn Ser Lys Pro Ile His Thr Thr Ile Leu 
    450                 455                 460                 


Asn Pro His Val His Val Ile Gly Glu Asp Ala Ala Cys Ile Ala Tyr 
465                 470                 475                 480 


Ile Arg Leu Thr Gln Tyr Ile Asp Gly Gln Gly Arg Pro Arg Thr Ser 
                485                 490                 495     


Gln Ser Glu Glu Thr Arg Val Trp His Arg Arg Asp Gly Lys Trp Leu 
            500                 505                 510         


Asn Val His Tyr His Cys Ser Gly Ala Pro Ala Ala Pro Leu Gln 
        515                 520                 525         


<210>  45
<211>  912
<212>  DNA
<213>  Homo sapiens

<400>  45
atggcagatg atcagggctg tattgaagag cagggggttg aggattcagc aaatgaagat       60

tcagtggatg ctaagccaga ccggtcctcg tttgtaccgt ccctcttcag taagaagaag      120

aaaaatgtca ccatgcgatc catcaagacc acccgggacc gagtgcctac atatcagtac      180

aacatgaatt ttgaaaagct gggcaaatgc atcataataa acaacaagaa ctttgataaa      240

gtgacaggta tgggcgttcg aaacggaaca gacaaagatg ccgaggcgct cttcaagtgc      300

ttccgaagcc tgggttttga cgtgattgtc tataatgact gctcttgtgc caagatgcaa      360

gatctgctta aaaaagcttc tgaagaggac catacaaatg ccgcctgctt cgcctgcatc      420

ctcttaagcc atggagaaga aaatgtaatt tatgggaaag atggtgtcac accaataaag      480

gatttgacag cccactttag gggggataga tgcaaaaccc ttttagagaa acccaaactc      540

ttcttcattc aggcttgccg agggaccgag cttgatgatg gcatccaggc cgactcgggg      600

cccatcaatg acacagatgc taatcctcga tacaagatcc cagtggaagc tgacttcctc      660

ttcgcctatt ccacggttcc aggctattac tcgtggagga gcccaggaag aggctcctgg      720

tttgtgcaag ccctctgctc catcctggag gagcacggaa aagacctgga aatcatgcag      780

atcctcacca gggtgaatga cagagttgcc aggcactttg agtctcagtc tgatgaccca      840

cacttccatg agaagaagca gatcccctgt gtggtctcca tgctcaccaa ggaactctac      900

ttcagtcaat ag                                                          912


<210>  46
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Ala Asp Asp Gln Gly Cys Ile Glu Glu Gln Gly Val Glu Asp Ser 
1               5                   10                  15      


Ala Asn Glu Asp Ser Val Asp Ala Lys Pro Asp Arg Ser Ser Phe Val 
            20                  25                  30          


Pro Ser Leu Phe Ser Lys Lys Lys Lys Asn Val Thr Met Arg Ser Ile 
        35                  40                  45              


Lys Thr Thr Arg Asp Arg Val Pro Thr Tyr Gln Tyr Asn Met Asn Phe 
    50                  55                  60                  


Glu Lys Leu Gly Lys Cys Ile Ile Ile Asn Asn Lys Asn Phe Asp Lys 
65                  70                  75                  80  


Val Thr Gly Met Gly Val Arg Asn Gly Thr Asp Lys Asp Ala Glu Ala 
                85                  90                  95      


Leu Phe Lys Cys Phe Arg Ser Leu Gly Phe Asp Val Ile Val Tyr Asn 
            100                 105                 110         


Asp Cys Ser Cys Ala Lys Met Gln Asp Leu Leu Lys Lys Ala Ser Glu 
        115                 120                 125             


Glu Asp His Thr Asn Ala Ala Cys Phe Ala Cys Ile Leu Leu Ser His 
    130                 135                 140                 


Gly Glu Glu Asn Val Ile Tyr Gly Lys Asp Gly Val Thr Pro Ile Lys 
145                 150                 155                 160 


Asp Leu Thr Ala His Phe Arg Gly Asp Arg Cys Lys Thr Leu Leu Glu 
                165                 170                 175     


Lys Pro Lys Leu Phe Phe Ile Gln Ala Cys Arg Gly Thr Glu Leu Asp 
            180                 185                 190         


Asp Gly Ile Gln Ala Asp Ser Gly Pro Ile Asn Asp Thr Asp Ala Asn 
        195                 200                 205             


Pro Arg Tyr Lys Ile Pro Val Glu Ala Asp Phe Leu Phe Ala Tyr Ser 
    210                 215                 220                 


Thr Val Pro Gly Tyr Tyr Ser Trp Arg Ser Pro Gly Arg Gly Ser Trp 
225                 230                 235                 240 


Phe Val Gln Ala Leu Cys Ser Ile Leu Glu Glu His Gly Lys Asp Leu 
                245                 250                 255     


Glu Ile Met Gln Ile Leu Thr Arg Val Asn Asp Arg Val Ala Arg His 
            260                 265                 270         


Phe Glu Ser Gln Ser Asp Asp Pro His Phe His Glu Lys Lys Gln Ile 
        275                 280                 285             


Pro Cys Val Val Ser Met Leu Thr Lys Glu Leu Tyr Phe Ser Gln 
    290                 295                 300             


<210>  47
<211>  537
<212>  DNA
<213>  Homo sapiens

<400>  47
atgtctgggg gcaaatacgt agactcggag ggacatctct acaccgttcc catccgggaa       60

cagggcaaca tctacaagcc caacaacaag gccatggcag acgagctgag cgagaagcaa      120

gtgtacgacg cgcacaccaa ggagatcgac ctggtcaacc gcgaccctaa acacctcaac      180

gatgacgtgg tcaagattga ctttgaagat gtgattgcag aaccagaagg gacacacagt      240

tttgacggca tttggaaggc cagcttcacc accttcactg tgacgaaata ctggttttac      300

cgcttgctgt ctgccctctt tggcatcccg atggcactca tctggggcat ttacttcgcc      360

attctctctt tcctgcacat ctgggcagtt gtaccatgca ttaagagctt cctgattgag      420

attcagtgca tcagccgtgt ctattccatc tacgtccaca ccgtctgtga cccactcttt      480

gaagctgttg ggaaaatatt cagcaatgtc cgcatcaact tgcagaaaga aatataa         537


<210>  48
<211>  178
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Ser Gly Gly Lys Tyr Val Asp Ser Glu Gly His Leu Tyr Thr Val 
1               5                   10                  15      


Pro Ile Arg Glu Gln Gly Asn Ile Tyr Lys Pro Asn Asn Lys Ala Met 
            20                  25                  30          


Ala Asp Glu Leu Ser Glu Lys Gln Val Tyr Asp Ala His Thr Lys Glu 
        35                  40                  45              


Ile Asp Leu Val Asn Arg Asp Pro Lys His Leu Asn Asp Asp Val Val 
    50                  55                  60                  


Lys Ile Asp Phe Glu Asp Val Ile Ala Glu Pro Glu Gly Thr His Ser 
65                  70                  75                  80  


Phe Asp Gly Ile Trp Lys Ala Ser Phe Thr Thr Phe Thr Val Thr Lys 
                85                  90                  95      


Tyr Trp Phe Tyr Arg Leu Leu Ser Ala Leu Phe Gly Ile Pro Met Ala 
            100                 105                 110         


Leu Ile Trp Gly Ile Tyr Phe Ala Ile Leu Ser Phe Leu His Ile Trp 
        115                 120                 125             


Ala Val Val Pro Cys Ile Lys Ser Phe Leu Ile Glu Ile Gln Cys Ile 
    130                 135                 140                 


Ser Arg Val Tyr Ser Ile Tyr Val His Thr Val Cys Asp Pro Leu Phe 
145                 150                 155                 160 


Glu Ala Val Gly Lys Ile Phe Ser Asn Val Arg Ile Asn Leu Gln Lys 
                165                 170                 175     


Glu Ile 
        


<210>  49
<211>  489
<212>  DNA
<213>  Homo sapiens

<400>  49
atggggctgg agacggagaa ggcggacgta cagctcttca tggacgacga ctcctacagc       60

caccacagcg gcctcgagta cgccgacccc gagaagttcg cggactcgga ccaggaccgg      120

gatccccacc ggctcaactc gcatctcaag ctgggcttcg aggatgtgat cgcagagccg      180

gtgactacgc actcctttga caaagtgtgg atctgcagcc atgccctctt tgaaatcagc      240

aaatacgtaa tgtacaagtt cctgacggtg ttcctggcca ttcccctggc cttcattgcg      300

ggaattctct ttgccaccct cagctgtctg cacatctgga ttttaatgcc ttttgtaaag      360

acctgcctaa tggttctgcc ttcagtgcag acaatatgga agagtgtgac agatgttatc      420

attgctccat tgtgtacgag cgtaggacga tgcttctctt ctgtcagcct gcaactgagc      480

caggattga                                                              489


<210>  50
<211>  162
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Gly Leu Glu Thr Glu Lys Ala Asp Val Gln Leu Phe Met Asp Asp 
1               5                   10                  15      


Asp Ser Tyr Ser His His Ser Gly Leu Glu Tyr Ala Asp Pro Glu Lys 
            20                  25                  30          


Phe Ala Asp Ser Asp Gln Asp Arg Asp Pro His Arg Leu Asn Ser His 
        35                  40                  45              


Leu Lys Leu Gly Phe Glu Asp Val Ile Ala Glu Pro Val Thr Thr His 
    50                  55                  60                  


Ser Phe Asp Lys Val Trp Ile Cys Ser His Ala Leu Phe Glu Ile Ser 
65                  70                  75                  80  


Lys Tyr Val Met Tyr Lys Phe Leu Thr Val Phe Leu Ala Ile Pro Leu 
                85                  90                  95      


Ala Phe Ile Ala Gly Ile Leu Phe Ala Thr Leu Ser Cys Leu His Ile 
            100                 105                 110         


Trp Ile Leu Met Pro Phe Val Lys Thr Cys Leu Met Val Leu Pro Ser 
        115                 120                 125             


Val Gln Thr Ile Trp Lys Ser Val Thr Asp Val Ile Ile Ala Pro Leu 
    130                 135                 140                 


Cys Thr Ser Val Gly Arg Cys Phe Ser Ser Val Ser Leu Gln Leu Ser 
145                 150                 155                 160 


Gln Asp 
        


<210>  51
<211>  552
<212>  DNA
<213>  Homo sapiens

<400>  51
atggcctcca acaaaactac attgcaaaaa atgggaaaaa aacagaatgg aaagagtaaa       60

aaagttgaag aggcagagcc tgaagaattt gtcgtggaaa aagtactaga tcgacgtgta      120

gtgaatggga aagtggaata tttcctgaag tggaagggat ttacagatgc tgacaatact      180

tgggaacctg aagaaaattt agattgtcca gaattgattg aagcgtttct taactctcag      240

aaagctggca aagaaaaaga tggtacaaaa agaaaatctt tatctgacag tgaatctgat      300

gacagcaaat caaagaagaa aagagatgct gctgacaaac caagaggatt tgccagaggt      360

cttgatcctg aaagaataat tggtgccaca gacagcagtg gagaattgat gtttctcatg      420

aaatggaaag attcagatga ggcagacttg gtgctggcga aagaggcaaa tatgaagtgt      480

cctcaaattg taattgcttt ttatgaagag agactaactt ggcattcttg tccagaagat      540

gaagctcaat aa                                                          552


<210>  52
<211>  183
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ala Ser Asn Lys Thr Thr Leu Gln Lys Met Gly Lys Lys Gln Asn 
1               5                   10                  15      


Gly Lys Ser Lys Lys Val Glu Glu Ala Glu Pro Glu Glu Phe Val Val 
            20                  25                  30          


Glu Lys Val Leu Asp Arg Arg Val Val Asn Gly Lys Val Glu Tyr Phe 
        35                  40                  45              


Leu Lys Trp Lys Gly Phe Thr Asp Ala Asp Asn Thr Trp Glu Pro Glu 
    50                  55                  60                  


Glu Asn Leu Asp Cys Pro Glu Leu Ile Glu Ala Phe Leu Asn Ser Gln 
65                  70                  75                  80  


Lys Ala Gly Lys Glu Lys Asp Gly Thr Lys Arg Lys Ser Leu Ser Asp 
                85                  90                  95      


Ser Glu Ser Asp Asp Ser Lys Ser Lys Lys Lys Arg Asp Ala Ala Asp 
            100                 105                 110         


Lys Pro Arg Gly Phe Ala Arg Gly Leu Asp Pro Glu Arg Ile Ile Gly 
        115                 120                 125             


Ala Thr Asp Ser Ser Gly Glu Leu Met Phe Leu Met Lys Trp Lys Asp 
    130                 135                 140                 


Ser Asp Glu Ala Asp Leu Val Leu Ala Lys Glu Ala Asn Met Lys Cys 
145                 150                 155                 160 


Pro Gln Ile Val Ile Ala Phe Tyr Glu Glu Arg Leu Thr Trp His Ser 
                165                 170                 175     


Cys Pro Glu Asp Glu Ala Gln 
            180             


<210>  53
<211>  576
<212>  DNA
<213>  Homo sapiens

<400>  53
atgcagacaa ttaagtgtgt tgttgtgggc gatggtgctg ttggtaaaac atgtctcctg       60

atatcctaca caacaaacaa atttccatcg gaatatgtac cgactgtttt tgacaactat      120

gcagtcacag ttatgattgg tggagaacca tatactcttg gactttttga tactgcaggg      180

caagaggatt atgacagatt acgaccgctg agttatccac aaacagatgt atttctagtc      240

tgtttttcag tggtctctcc atcttcattt gaaaacgtga aagaaaagtg ggtgcctgag      300

ataactcacc actgtccaaa gactcctttc ttgcttgttg ggactcaaat tgatctcaga      360

gatgacccct ctactattga gaaacttgcc aagaacaaac agaagcctat cactccagag      420

actgctgaaa agctggcccg tgacctgaag gctgtcaagt atgtggagtg ttctgcactt      480

acacagagag gtctgaagaa tgtgtttgat gaggctatcc tagctgccct cgagcctccg      540

gaaactcaac ccaaaaggaa gtgctgtata ttctaa                                576


<210>  54
<211>  191
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Gln Thr Ile Lys Cys Val Val Val Gly Asp Gly Ala Val Gly Lys 
1               5                   10                  15      


Thr Cys Leu Leu Ile Ser Tyr Thr Thr Asn Lys Phe Pro Ser Glu Tyr 
            20                  25                  30          


Val Pro Thr Val Phe Asp Asn Tyr Ala Val Thr Val Met Ile Gly Gly 
        35                  40                  45              


Glu Pro Tyr Thr Leu Gly Leu Phe Asp Thr Ala Gly Gln Glu Asp Tyr 
    50                  55                  60                  


Asp Arg Leu Arg Pro Leu Ser Tyr Pro Gln Thr Asp Val Phe Leu Val 
65                  70                  75                  80  


Cys Phe Ser Val Val Ser Pro Ser Ser Phe Glu Asn Val Lys Glu Lys 
                85                  90                  95      


Trp Val Pro Glu Ile Thr His His Cys Pro Lys Thr Pro Phe Leu Leu 
            100                 105                 110         


Val Gly Thr Gln Ile Asp Leu Arg Asp Asp Pro Ser Thr Ile Glu Lys 
        115                 120                 125             


Leu Ala Lys Asn Lys Gln Lys Pro Ile Thr Pro Glu Thr Ala Glu Lys 
    130                 135                 140                 


Leu Ala Arg Asp Leu Lys Ala Val Lys Tyr Val Glu Cys Ser Ala Leu 
145                 150                 155                 160 


Thr Gln Arg Gly Leu Lys Asn Val Phe Asp Glu Ala Ile Leu Ala Ala 
                165                 170                 175     


Leu Glu Pro Pro Glu Thr Gln Pro Lys Arg Lys Cys Cys Ile Phe 
            180                 185                 190     


<210>  55
<211>  897
<212>  DNA
<213>  Homo sapiens

<400>  55
atggagaact tccaaaaggt ggaaaagatc ggagagggca cgtacggagt tgtgtacaaa       60

gccagaaaca agttgacggg agaggtggtg gcgcttaaga aaatccgcct ggacactgag      120

actgagggtg tgcccagtac tgccatccga gagatctctc tgcttaagga gcttaaccat      180

cctaatattg tcaagctgct ggatgtcatt cacacagaaa ataaactcta cctggttttt      240

gaatttctgc accaagatct caagaaattc atggatgcct ctgctctcac tggcattcct      300

cttcccctca tcaagagcta tctgttccag ctgctccagg gcctagcttt ctgccattct      360

catcgggtcc tccaccgaga ccttaaacct cagaatctgc ttattaacac agagggggcc      420

atcaagctag cagactttgg actagccaga gcttttggag tccctgttcg tacttacacc      480

catgaggtgg tgaccctgtg gtaccgagct cctgaaatcc tcctgggctg caaatattat      540

tccacagctg tggacatctg gagcctgggc tgcatctttg ctgagatggt gactcgccgg      600

gccctattcc ctggagattc tgagattgac cagctcttcc ggatctttcg gactctgggg      660

accccagatg aggtggtgtg gccaggagtt acttctatgc ctgattacaa gccaagtttc      720

cccaagtggg cccggcaaga ttttagtaaa gttgtacctc ccctggatga agatggacgg      780

agcttgttat cgcaaatgct gcactacgac cctaacaagc ggatttcggc caaggcagcc      840

ctggctcacc ctttcttcca ggatgtgacc aagccagtac cccatcttcg actctga         897


<210>  56
<211>  298
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Glu Asn Phe Gln Lys Val Glu Lys Ile Gly Glu Gly Thr Tyr Gly 
1               5                   10                  15      


Val Val Tyr Lys Ala Arg Asn Lys Leu Thr Gly Glu Val Val Ala Leu 
            20                  25                  30          


Lys Lys Ile Arg Leu Asp Thr Glu Thr Glu Gly Val Pro Ser Thr Ala 
        35                  40                  45              


Ile Arg Glu Ile Ser Leu Leu Lys Glu Leu Asn His Pro Asn Ile Val 
    50                  55                  60                  


Lys Leu Leu Asp Val Ile His Thr Glu Asn Lys Leu Tyr Leu Val Phe 
65                  70                  75                  80  


Glu Phe Leu His Gln Asp Leu Lys Lys Phe Met Asp Ala Ser Ala Leu 
                85                  90                  95      


Thr Gly Ile Pro Leu Pro Leu Ile Lys Ser Tyr Leu Phe Gln Leu Leu 
            100                 105                 110         


Gln Gly Leu Ala Phe Cys His Ser His Arg Val Leu His Arg Asp Leu 
        115                 120                 125             


Lys Pro Gln Asn Leu Leu Ile Asn Thr Glu Gly Ala Ile Lys Leu Ala 
    130                 135                 140                 


Asp Phe Gly Leu Ala Arg Ala Phe Gly Val Pro Val Arg Thr Tyr Thr 
145                 150                 155                 160 


His Glu Val Val Thr Leu Trp Tyr Arg Ala Pro Glu Ile Leu Leu Gly 
                165                 170                 175     


Cys Lys Tyr Tyr Ser Thr Ala Val Asp Ile Trp Ser Leu Gly Cys Ile 
            180                 185                 190         


Phe Ala Glu Met Val Thr Arg Arg Ala Leu Phe Pro Gly Asp Ser Glu 
        195                 200                 205             


Ile Asp Gln Leu Phe Arg Ile Phe Arg Thr Leu Gly Thr Pro Asp Glu 
    210                 215                 220                 


Val Val Trp Pro Gly Val Thr Ser Met Pro Asp Tyr Lys Pro Ser Phe 
225                 230                 235                 240 


Pro Lys Trp Ala Arg Gln Asp Phe Ser Lys Val Val Pro Pro Leu Asp 
                245                 250                 255     


Glu Asp Gly Arg Ser Leu Leu Ser Gln Met Leu His Tyr Asp Pro Asn 
            260                 265                 270         


Lys Arg Ile Ser Ala Lys Ala Ala Leu Ala His Pro Phe Phe Gln Asp 
        275                 280                 285             


Val Thr Lys Pro Val Pro His Leu Arg Leu 
    290                 295             


<210>  57
<211>  912
<212>  DNA
<213>  Homo sapiens

<400>  57
atggctacct ctcgatatga gccagtggct gaaattggtg tcggtgccta tgggacagtg       60

tacaaggccc gtgatcccca cagtggccac tttgtggccc tcaagagtgt gagagtcccc      120

aatggaggag gaggtggagg aggccttccc atcagcacag ttcgtgaggt ggctttactg      180

aggcgactgg aggcttttga gcatcccaat gttgtccggc tgatggacgt ctgtgccaca      240

tcccgaactg accgggagat caaggtaacc ctggtgtttg agcatgtaga ccaggaccta      300

aggacatatc tggacaaggc acccccacca ggcttgccag ccgaaacgat caaggatctg      360

atgcgccagt ttctaagagg cctagatttc cttcatgcca attgcatcgt tcaccgagat      420

ctgaagccag agaacattct ggtgacaagt ggtggaacag tcaagctggc tgactttggc      480

ctggccagaa tctacagcta ccagatggca cttacacccg tggttgttac actctggtac      540

cgagctcccg aagttcttct gcagtccaca tatgcaacac ctgtggacat gtggagtgtt      600

ggctgtatct ttgcagagat gtttcgtcga aagcctctct tctgtggaaa ctctgaagcc      660

gaccagttgg gcaaaatctt tgacctgatt gggctgcctc cagaggatga ctggcctcga      720

gatgtatccc tgccccgtgg agcctttccc cccagagggc cccgcccagt gcagtcggtg      780

gtacctgaga tggaggagtc gggagcacag ctgctgctgg aaatgctgac ttttaaccca      840

cacaagcgaa tctctgcctt tcgagctctg cagcactctt atctacataa ggatgaaggt      900

aatccggagt ga                                                          912


<210>  58
<211>  303
<212>  PRT
<213>  Homo sapiens

<400>  58

Met Ala Thr Ser Arg Tyr Glu Pro Val Ala Glu Ile Gly Val Gly Ala 
1               5                   10                  15      


Tyr Gly Thr Val Tyr Lys Ala Arg Asp Pro His Ser Gly His Phe Val 
            20                  25                  30          


Ala Leu Lys Ser Val Arg Val Pro Asn Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Leu Pro Ile Ser Thr Val Arg Glu Val Ala Leu Leu Arg Arg Leu Glu 
    50                  55                  60                  


Ala Phe Glu His Pro Asn Val Val Arg Leu Met Asp Val Cys Ala Thr 
65                  70                  75                  80  


Ser Arg Thr Asp Arg Glu Ile Lys Val Thr Leu Val Phe Glu His Val 
                85                  90                  95      


Asp Gln Asp Leu Arg Thr Tyr Leu Asp Lys Ala Pro Pro Pro Gly Leu 
            100                 105                 110         


Pro Ala Glu Thr Ile Lys Asp Leu Met Arg Gln Phe Leu Arg Gly Leu 
        115                 120                 125             


Asp Phe Leu His Ala Asn Cys Ile Val His Arg Asp Leu Lys Pro Glu 
    130                 135                 140                 


Asn Ile Leu Val Thr Ser Gly Gly Thr Val Lys Leu Ala Asp Phe Gly 
145                 150                 155                 160 


Leu Ala Arg Ile Tyr Ser Tyr Gln Met Ala Leu Thr Pro Val Val Val 
                165                 170                 175     


Thr Leu Trp Tyr Arg Ala Pro Glu Val Leu Leu Gln Ser Thr Tyr Ala 
            180                 185                 190         


Thr Pro Val Asp Met Trp Ser Val Gly Cys Ile Phe Ala Glu Met Phe 
        195                 200                 205             


Arg Arg Lys Pro Leu Phe Cys Gly Asn Ser Glu Ala Asp Gln Leu Gly 
    210                 215                 220                 


Lys Ile Phe Asp Leu Ile Gly Leu Pro Pro Glu Asp Asp Trp Pro Arg 
225                 230                 235                 240 


Asp Val Ser Leu Pro Arg Gly Ala Phe Pro Pro Arg Gly Pro Arg Pro 
                245                 250                 255     


Val Gln Ser Val Val Pro Glu Met Glu Glu Ser Gly Ala Gln Leu Leu 
            260                 265                 270         


Leu Glu Met Leu Thr Phe Asn Pro His Lys Arg Ile Ser Ala Phe Arg 
        275                 280                 285             


Ala Leu Gln His Ser Tyr Leu His Lys Asp Glu Gly Asn Pro Glu 
    290                 295                 300             


<210>  59
<211>  1041
<212>  DNA
<213>  Homo sapiens

<400>  59
atggctctgg acgtgaagtc tcgggcaaag cgttatgaga agctggactt ccttggggag       60

ggacagtttg ccaccgttta caaggccaga gataagaaca ccaaccaaat tgtcgccatt      120

aagaaaatca aacttggaca tagatcagaa gctaaagatg gtataaatag aaccgcctta      180

agagagataa aattattaca ggagctaagt catccaaata taattggtct ccttgatgct      240

tttggacata aatctaatat tagccttgtc tttgatttta tggaaactga tctagaggtt      300

ataataaagg ataatagtct tgtgctgaca ccatcacaca tcaaagccta catgttgatg      360

actcttcaag gattagaata tttacatcaa cattggatcc tacataggga tctgaaacca      420

aacaacttgt tgctagatga aaatggagtt ctaaaactgg cagattttgg cctggccaaa      480

tcttttggga gccccaatag agcttataca catcaggttg taaccaggtg gtatcgggcc      540

cccgagttac tatttggagc taggatgtat ggtgtaggtg tggacatgtg ggctgttggc      600

tgtatattag cagagttact tctaagggtt ccttttttgc caggagattc agaccttgat      660

cagctaacaa gaatatttga aactttgggc acaccaactg aggaacagtg gccggacatg      720

tgtagtcttc cagattatgt gacatttaag agtttccctg gaataccttt gcatcacatc      780

ttcagtgcag caggagacga cttactagat ctcatacaag gcttattctt atttaatcca      840

tgtgctcgaa ttacggccac acaggcactg aaaatgaagt atttcagtaa tcggccaggg      900

ccaacacctg gatgtcagct gccaagacca aactgtccag tggaaacctt aaaggagcaa      960

tcaaatccag ctttggcaat aaaaaggaaa agaacagagg ccttagaaca aggaggattg     1020

cccaagaaac taatttttta a                                               1041


<210>  60
<211>  346
<212>  PRT
<213>  Homo sapiens

<400>  60

Met Ala Leu Asp Val Lys Ser Arg Ala Lys Arg Tyr Glu Lys Leu Asp 
1               5                   10                  15      


Phe Leu Gly Glu Gly Gln Phe Ala Thr Val Tyr Lys Ala Arg Asp Lys 
            20                  25                  30          


Asn Thr Asn Gln Ile Val Ala Ile Lys Lys Ile Lys Leu Gly His Arg 
        35                  40                  45              


Ser Glu Ala Lys Asp Gly Ile Asn Arg Thr Ala Leu Arg Glu Ile Lys 
    50                  55                  60                  


Leu Leu Gln Glu Leu Ser His Pro Asn Ile Ile Gly Leu Leu Asp Ala 
65                  70                  75                  80  


Phe Gly His Lys Ser Asn Ile Ser Leu Val Phe Asp Phe Met Glu Thr 
                85                  90                  95      


Asp Leu Glu Val Ile Ile Lys Asp Asn Ser Leu Val Leu Thr Pro Ser 
            100                 105                 110         


His Ile Lys Ala Tyr Met Leu Met Thr Leu Gln Gly Leu Glu Tyr Leu 
        115                 120                 125             


His Gln His Trp Ile Leu His Arg Asp Leu Lys Pro Asn Asn Leu Leu 
    130                 135                 140                 


Leu Asp Glu Asn Gly Val Leu Lys Leu Ala Asp Phe Gly Leu Ala Lys 
145                 150                 155                 160 


Ser Phe Gly Ser Pro Asn Arg Ala Tyr Thr His Gln Val Val Thr Arg 
                165                 170                 175     


Trp Tyr Arg Ala Pro Glu Leu Leu Phe Gly Ala Arg Met Tyr Gly Val 
            180                 185                 190         


Gly Val Asp Met Trp Ala Val Gly Cys Ile Leu Ala Glu Leu Leu Leu 
        195                 200                 205             


Arg Val Pro Phe Leu Pro Gly Asp Ser Asp Leu Asp Gln Leu Thr Arg 
    210                 215                 220                 


Ile Phe Glu Thr Leu Gly Thr Pro Thr Glu Glu Gln Trp Pro Asp Met 
225                 230                 235                 240 


Cys Ser Leu Pro Asp Tyr Val Thr Phe Lys Ser Phe Pro Gly Ile Pro 
                245                 250                 255     


Leu His His Ile Phe Ser Ala Ala Gly Asp Asp Leu Leu Asp Leu Ile 
            260                 265                 270         


Gln Gly Leu Phe Leu Phe Asn Pro Cys Ala Arg Ile Thr Ala Thr Gln 
        275                 280                 285             


Ala Leu Lys Met Lys Tyr Phe Ser Asn Arg Pro Gly Pro Thr Pro Gly 
    290                 295                 300                 


Cys Gln Leu Pro Arg Pro Asn Cys Pro Val Glu Thr Leu Lys Glu Gln 
305                 310                 315                 320 


Ser Asn Pro Ala Leu Ala Ile Lys Arg Lys Arg Thr Glu Ala Leu Glu 
                325                 330                 335     


Gln Gly Gly Leu Pro Lys Lys Leu Ile Phe 
            340                 345     


<210>  61
<211>  1740
<212>  DNA
<213>  Homo sapiens

<400>  61
atggcgcagg aggtgtcgga gtacctgagc cagaacccgc gggtggcagc ctgggtggag       60

gcgctgcgct gcgacggcga gactgacaaa cactggcgcc accgccggga ttttttgctt      120

cgcaacgccg gggacctggc ccccgctggc ggcgctgcct ccgctagcac ggatgaagct      180

gccgacgccg agagcgggac ccgaaaccgg cagctgcagc agctcatctc cttttccatg      240

gcctgggcga accacgtctt cctcgggtgc cgataccctc aaaaagttat ggataaaata      300

cttagtatgg ctgaaggcat caaagtgaca gatgctccaa cctatacaac aagagatgaa      360

ctggttgcca aggtgaagaa aagagggata tcgagtagca atgaaggggt agaagagcca      420

tccaaaaaac gagttataga aggaaaaaac agttctgcag ttgagcaaga tcacgcaaaa      480

acctctgcca agacagaacg tgcatcagct cagcaggaaa acagttcaac gtgtataggg      540

tcggccatca aatcagagag tgggaactca gctcggagct ctggcatctc cagtcagaat      600

agctctacaa gtgatggaga tcgatctgtt tccagccaaa gcagcagcag cgtttcctct      660

caggtaacaa cggcaggatc tgggaaagct tctgaagcag aagctccaga taaacacggt      720

tcatcatttg tttccttgct gaaatccagt gtgaatagtc acatgaccca atccactgat      780

tctagacaac aaagtggatc acctaaaaag agtgctttgg aaggctcttc agcctcagct      840

tctcaaagca gctcagagat cgaggtgccc ttgttgggct cctcaggaag ctcagaggta      900

gaattgccac tattgtcttc caaacctagt tcagagacag cttcaagtgg gttaacttcc      960

aaaactagtt cagaggcaag tgtttcatca tcagttgcta aaaacagttc ctcatcaggc     1020

acatccttac tgactcccaa gagcagctct tcaacaaata catcgctgct aacttccaag     1080

agcacttccc aggtagctgc atcactacta gcttccaaga gcagctccca gaccagtgga     1140

tctctggttt ccaaaagcac ttccttagca agtgtgtccc agttggcttc taagagtagt     1200

tctcagacta gcacctcaca gttgccttct aaaagtactt cacagtcaag tgagagttct     1260

gtcaaattct cttgcaagtt aaccaatgaa gatgtgaaac agaagcaacc ttttttcaat     1320

agactatata aaacggtggc atggaagttg gtagctgttg gtggctttag tcccaatgtg     1380

aatcatggag agctcctaaa tgcagctatt gaggctctga aagcaacact ggatgtattt     1440

tttgtcccac taaaagaatt ggcagatctg cctcaaaata agagctctca agaaagtatt     1500

gtttgtgaat tgaggtgcaa gtctgtgtat ttgggcactg gctgtggaaa aagcaaagaa     1560

aatgcaaaag cagttgcatc aagagaagca ttgaagttat ttctcaagaa aaaggtggtg     1620

gtaaaaatat gtaaaaggaa atacagaggc agtgaaatag aagatctagt actccttgat     1680

gaagaatcga ggcctgtaaa cttacctcca gcactaaaac atcctcaaga attactataa     1740


<210>  62
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  62

Met Ala Gln Glu Val Ser Glu Tyr Leu Ser Gln Asn Pro Arg Val Ala 
1               5                   10                  15      


Ala Trp Val Glu Ala Leu Arg Cys Asp Gly Glu Thr Asp Lys His Trp 
            20                  25                  30          


Arg His Arg Arg Asp Phe Leu Leu Arg Asn Ala Gly Asp Leu Ala Pro 
        35                  40                  45              


Ala Gly Gly Ala Ala Ser Ala Ser Thr Asp Glu Ala Ala Asp Ala Glu 
    50                  55                  60                  


Ser Gly Thr Arg Asn Arg Gln Leu Gln Gln Leu Ile Ser Phe Ser Met 
65                  70                  75                  80  


Ala Trp Ala Asn His Val Phe Leu Gly Cys Arg Tyr Pro Gln Lys Val 
                85                  90                  95      


Met Asp Lys Ile Leu Ser Met Ala Glu Gly Ile Lys Val Thr Asp Ala 
            100                 105                 110         


Pro Thr Tyr Thr Thr Arg Asp Glu Leu Val Ala Lys Val Lys Lys Arg 
        115                 120                 125             


Gly Ile Ser Ser Ser Asn Glu Gly Val Glu Glu Pro Ser Lys Lys Arg 
    130                 135                 140                 


Val Ile Glu Gly Lys Asn Ser Ser Ala Val Glu Gln Asp His Ala Lys 
145                 150                 155                 160 


Thr Ser Ala Lys Thr Glu Arg Ala Ser Ala Gln Gln Glu Asn Ser Ser 
                165                 170                 175     


Thr Cys Ile Gly Ser Ala Ile Lys Ser Glu Ser Gly Asn Ser Ala Arg 
            180                 185                 190         


Ser Ser Gly Ile Ser Ser Gln Asn Ser Ser Thr Ser Asp Gly Asp Arg 
        195                 200                 205             


Ser Val Ser Ser Gln Ser Ser Ser Ser Val Ser Ser Gln Val Thr Thr 
    210                 215                 220                 


Ala Gly Ser Gly Lys Ala Ser Glu Ala Glu Ala Pro Asp Lys His Gly 
225                 230                 235                 240 


Ser Ser Phe Val Ser Leu Leu Lys Ser Ser Val Asn Ser His Met Thr 
                245                 250                 255     


Gln Ser Thr Asp Ser Arg Gln Gln Ser Gly Ser Pro Lys Lys Ser Ala 
            260                 265                 270         


Leu Glu Gly Ser Ser Ala Ser Ala Ser Gln Ser Ser Ser Glu Ile Glu 
        275                 280                 285             


Val Pro Leu Leu Gly Ser Ser Gly Ser Ser Glu Val Glu Leu Pro Leu 
    290                 295                 300                 


Leu Ser Ser Lys Pro Ser Ser Glu Thr Ala Ser Ser Gly Leu Thr Ser 
305                 310                 315                 320 


Lys Thr Ser Ser Glu Ala Ser Val Ser Ser Ser Val Ala Lys Asn Ser 
                325                 330                 335     


Ser Ser Ser Gly Thr Ser Leu Leu Thr Pro Lys Ser Ser Ser Ser Thr 
            340                 345                 350         


Asn Thr Ser Leu Leu Thr Ser Lys Ser Thr Ser Gln Val Ala Ala Ser 
        355                 360                 365             


Leu Leu Ala Ser Lys Ser Ser Ser Gln Thr Ser Gly Ser Leu Val Ser 
    370                 375                 380                 


Lys Ser Thr Ser Leu Ala Ser Val Ser Gln Leu Ala Ser Lys Ser Ser 
385                 390                 395                 400 


Ser Gln Thr Ser Thr Ser Gln Leu Pro Ser Lys Ser Thr Ser Gln Ser 
                405                 410                 415     


Ser Glu Ser Ser Val Lys Phe Ser Cys Lys Leu Thr Asn Glu Asp Val 
            420                 425                 430         


Lys Gln Lys Gln Pro Phe Phe Asn Arg Leu Tyr Lys Thr Val Ala Trp 
        435                 440                 445             


Lys Leu Val Ala Val Gly Gly Phe Ser Pro Asn Val Asn His Gly Glu 
    450                 455                 460                 


Leu Leu Asn Ala Ala Ile Glu Ala Leu Lys Ala Thr Leu Asp Val Phe 
465                 470                 475                 480 


Phe Val Pro Leu Lys Glu Leu Ala Asp Leu Pro Gln Asn Lys Ser Ser 
                485                 490                 495     


Gln Glu Ser Ile Val Cys Glu Leu Arg Cys Lys Ser Val Tyr Leu Gly 
            500                 505                 510         


Thr Gly Cys Gly Lys Ser Lys Glu Asn Ala Lys Ala Val Ala Ser Arg 
        515                 520                 525             


Glu Ala Leu Lys Leu Phe Leu Lys Lys Lys Val Val Val Lys Ile Cys 
    530                 535                 540                 


Lys Arg Lys Tyr Arg Gly Ser Glu Ile Glu Asp Leu Val Leu Leu Asp 
545                 550                 555                 560 


Glu Glu Ser Arg Pro Val Asn Leu Pro Pro Ala Leu Lys His Pro Gln 
                565                 570                 575     


Glu Leu Leu 
            


<210>  63
<211>  1656
<212>  DNA
<213>  Homo sapiens

<400>  63
atggaagaag aacttcctct tttctctgga gacagtggca agccagtaca ggctactctg       60

tcatctttga agatgttaga tgtgggaaag tggccaattt tttccctttg ttctgaagaa      120

gaactacagt taattcgtca ggcttgtgtc tttggcagtg ctggcaatga agttttatac      180

actacagtaa atgatgagat ttttgtgctt ggcacaaact gctgtggctg tttggggtta      240

ggtgacgtcc agagcaccat tgaacctcgg agactggatt ctttaaatgg caaaaaaata      300

gcctgcctca gctatgggag tggtccacat attgtccttg caacaacaga aggagaagtc      360

tttacctggg gtcataatgc ttatagccag ctgggcaatg ggacaactaa tcatggttta      420

gtgccctgtc atatctctac taatctgtca aacaaacaag tcattgaagt tgcctgtggg      480

tcttaccatt ctttggtgct aacatctgat ggagaggtat ttgcctgggg ttataataac      540

tctgggcagg taggatctgg atcaacagtt aatcagccaa tccctcgaag agtcactggc      600

tgcctacaaa ataaagtagt tgtgaccata gcatgtgggc agatgtgctg catggcagta      660

gtagacacgg gggaggtcta tgtctggggt tacaacggaa acgggcagct tggactcggc      720

aacagtggca accagccaac cccttgcaga gtggcagctt tgcaaggcat ccgtgtccag      780

agggtcgcct gtggctacgc acacacatta gtattaacag atgaaggcca agtgtatgct      840

tggggcgcca attcttatgg gcagttgggc actggcaata aaagcaacca gtcctatcct      900

actcctgtca ctgtggaaaa ggacaggatt atcgagattg cagcctgtca ctccacacac      960

acgtctgcgg ccaagacgca gggtgggcac gtgtacatgt ggggccagtg ccggggtcag     1020

tccgtgatcc tcccgcacct cacccacttc tcctgcactg acgacgtgtt tgcctgcttt     1080

gccacgcccg ccgtcacgtg gcgcctcctc tccgtggaac ctgatgacca cctcacagtg     1140

gctgagtcac tgaagaggga atttgacaac ccggacactg cagacctgaa gtttctagtt     1200

gatggaaagt acatttatgc acataaagtc cttctcaaga ttcgatgtga gcattttcgt     1260

tcgtcattgg aagataacga ggatgatatt gtagaaatga gtgaattttc atatcctgtt     1320

taccgggcct tcctggaata cctatacaca gacagcatca gcctttctcc tgaggaggca     1380

gtaggactgc tagacttggc tacattttat agagaaaatc gtttgaaaaa gctctgccaa     1440

caaactatca agcaaggcat ctgcgaggag aatgccatcg ctctgctctc ggctgcggtg     1500

aagtatgatg cacaggattt agaagaattc tgcttcaggt tttgcataaa ccatctgact     1560

gtagtaacac aaacatcagg ttttgcagaa atggaccatg atctcctgaa gaactttatc     1620

agcaaagcaa gcagagttgg agcctttaaa aattga                               1656


<210>  64
<211>  551
<212>  PRT
<213>  Homo sapiens

<400>  64

Met Glu Glu Glu Leu Pro Leu Phe Ser Gly Asp Ser Gly Lys Pro Val 
1               5                   10                  15      


Gln Ala Thr Leu Ser Ser Leu Lys Met Leu Asp Val Gly Lys Trp Pro 
            20                  25                  30          


Ile Phe Ser Leu Cys Ser Glu Glu Glu Leu Gln Leu Ile Arg Gln Ala 
        35                  40                  45              


Cys Val Phe Gly Ser Ala Gly Asn Glu Val Leu Tyr Thr Thr Val Asn 
    50                  55                  60                  


Asp Glu Ile Phe Val Leu Gly Thr Asn Cys Cys Gly Cys Leu Gly Leu 
65                  70                  75                  80  


Gly Asp Val Gln Ser Thr Ile Glu Pro Arg Arg Leu Asp Ser Leu Asn 
                85                  90                  95      


Gly Lys Lys Ile Ala Cys Leu Ser Tyr Gly Ser Gly Pro His Ile Val 
            100                 105                 110         


Leu Ala Thr Thr Glu Gly Glu Val Phe Thr Trp Gly His Asn Ala Tyr 
        115                 120                 125             


Ser Gln Leu Gly Asn Gly Thr Thr Asn His Gly Leu Val Pro Cys His 
    130                 135                 140                 


Ile Ser Thr Asn Leu Ser Asn Lys Gln Val Ile Glu Val Ala Cys Gly 
145                 150                 155                 160 


Ser Tyr His Ser Leu Val Leu Thr Ser Asp Gly Glu Val Phe Ala Trp 
                165                 170                 175     


Gly Tyr Asn Asn Ser Gly Gln Val Gly Ser Gly Ser Thr Val Asn Gln 
            180                 185                 190         


Pro Ile Pro Arg Arg Val Thr Gly Cys Leu Gln Asn Lys Val Val Val 
        195                 200                 205             


Thr Ile Ala Cys Gly Gln Met Cys Cys Met Ala Val Val Asp Thr Gly 
    210                 215                 220                 


Glu Val Tyr Val Trp Gly Tyr Asn Gly Asn Gly Gln Leu Gly Leu Gly 
225                 230                 235                 240 


Asn Ser Gly Asn Gln Pro Thr Pro Cys Arg Val Ala Ala Leu Gln Gly 
                245                 250                 255     


Ile Arg Val Gln Arg Val Ala Cys Gly Tyr Ala His Thr Leu Val Leu 
            260                 265                 270         


Thr Asp Glu Gly Gln Val Tyr Ala Trp Gly Ala Asn Ser Tyr Gly Gln 
        275                 280                 285             


Leu Gly Thr Gly Asn Lys Ser Asn Gln Ser Tyr Pro Thr Pro Val Thr 
    290                 295                 300                 


Val Glu Lys Asp Arg Ile Ile Glu Ile Ala Ala Cys His Ser Thr His 
305                 310                 315                 320 


Thr Ser Ala Ala Lys Thr Gln Gly Gly His Val Tyr Met Trp Gly Gln 
                325                 330                 335     


Cys Arg Gly Gln Ser Val Ile Leu Pro His Leu Thr His Phe Ser Cys 
            340                 345                 350         


Thr Asp Asp Val Phe Ala Cys Phe Ala Thr Pro Ala Val Thr Trp Arg 
        355                 360                 365             


Leu Leu Ser Val Glu Pro Asp Asp His Leu Thr Val Ala Glu Ser Leu 
    370                 375                 380                 


Lys Arg Glu Phe Asp Asn Pro Asp Thr Ala Asp Leu Lys Phe Leu Val 
385                 390                 395                 400 


Asp Gly Lys Tyr Ile Tyr Ala His Lys Val Leu Leu Lys Ile Arg Cys 
                405                 410                 415     


Glu His Phe Arg Ser Ser Leu Glu Asp Asn Glu Asp Asp Ile Val Glu 
            420                 425                 430         


Met Ser Glu Phe Ser Tyr Pro Val Tyr Arg Ala Phe Leu Glu Tyr Leu 
        435                 440                 445             


Tyr Thr Asp Ser Ile Ser Leu Ser Pro Glu Glu Ala Val Gly Leu Leu 
    450                 455                 460                 


Asp Leu Ala Thr Phe Tyr Arg Glu Asn Arg Leu Lys Lys Leu Cys Gln 
465                 470                 475                 480 


Gln Thr Ile Lys Gln Gly Ile Cys Glu Glu Asn Ala Ile Ala Leu Leu 
                485                 490                 495     


Ser Ala Ala Val Lys Tyr Asp Ala Gln Asp Leu Glu Glu Phe Cys Phe 
            500                 505                 510         


Arg Phe Cys Ile Asn His Leu Thr Val Val Thr Gln Thr Ser Gly Phe 
        515                 520                 525             


Ala Glu Met Asp His Asp Leu Leu Lys Asn Phe Ile Ser Lys Ala Ser 
    530                 535                 540                 


Arg Val Gly Ala Phe Lys Asn 
545                 550     


<210>  65
<211>  528
<212>  DNA
<213>  Homo sapiens

<400>  65
atggacatcg ccatccacca cccctggatc cgccgcccct tctttccttt ccactccccc       60

agccgcctct ttgaccagtt cttcggagag cacctgttgg agtctgatct tttcccgacg      120

tctacttccc tgagtccctt ctaccttcgg ccaccctcct tcctgcgggc acccagctgg      180

tttgacactg gactctcaga gatgcgcctg gagaaggaca ggttctctgt caacctggat      240

gtgaagcact tctccccaga ggaactcaaa gttaaggtgt tgggagatgt gattgaggtg      300

catggaaaac atgaagagcg ccaggatgaa catggtttca tctccaggga gttccacagg      360

aaataccgga tcccagctga tgtagaccct ctcaccatta cttcatccct gtcatctgat      420

ggggtcctca ctgtgaatgg accaaggaaa caggtctctg gccctgagcg caccattccc      480

atcacccgtg aagagaagcc tgctgtcacc gcagccccca agaaatag                   528


<210>  66
<211>  175
<212>  PRT
<213>  Homo sapiens

<400>  66

Met Asp Ile Ala Ile His His Pro Trp Ile Arg Arg Pro Phe Phe Pro 
1               5                   10                  15      


Phe His Ser Pro Ser Arg Leu Phe Asp Gln Phe Phe Gly Glu His Leu 
            20                  25                  30          


Leu Glu Ser Asp Leu Phe Pro Thr Ser Thr Ser Leu Ser Pro Phe Tyr 
        35                  40                  45              


Leu Arg Pro Pro Ser Phe Leu Arg Ala Pro Ser Trp Phe Asp Thr Gly 
    50                  55                  60                  


Leu Ser Glu Met Arg Leu Glu Lys Asp Arg Phe Ser Val Asn Leu Asp 
65                  70                  75                  80  


Val Lys His Phe Ser Pro Glu Glu Leu Lys Val Lys Val Leu Gly Asp 
                85                  90                  95      


Val Ile Glu Val His Gly Lys His Glu Glu Arg Gln Asp Glu His Gly 
            100                 105                 110         


Phe Ile Ser Arg Glu Phe His Arg Lys Tyr Arg Ile Pro Ala Asp Val 
        115                 120                 125             


Asp Pro Leu Thr Ile Thr Ser Ser Leu Ser Ser Asp Gly Val Leu Thr 
    130                 135                 140                 


Val Asn Gly Pro Arg Lys Gln Val Ser Gly Pro Glu Arg Thr Ile Pro 
145                 150                 155                 160 


Ile Thr Arg Glu Glu Lys Pro Ala Val Thr Ala Ala Pro Lys Lys 
                165                 170                 175 


<210>  67
<211>  785
<212>  DNA
<213>  Homo sapiens

<400>  67
atggcgagta gcagcggctc caaggctgaa ttcattgtcg gagggaaata taaactggta       60

cggaagatcg ggtctggctc cttcggggac atctatttgg cgatcaacat caccaacggc      120

gaggaagtgg cagtgaagct agaatctcag aaggccaggc atccccagtt gctgtacgag      180

agcaagctct ataagattct tcaaggtggg gttggcatcc cccacatacg gtggtatggt      240

caggaaaaag actacaatgt actagtcatg gatcttctgg gacctagcct cgaagacctc      300

ttcaatttct gttcaagaag gttcacaatg aaaactgtac ttatgttagc tgaccagatg      360

atcagtagaa ttgaatatgt gcatacaaag aattttatac acagagacat taaaccagat      420

aacttcctaa tgggtattgg gcgtcactgt aataagtgtt tagaatctcc agtggggaag      480

aggaaaagaa gcatgactgt tagtacttct caggacccat ctttctcagg attaaaccag      540

ttattcctta ttgattttgg tttggccaaa aagtacagag acaacaggac aaggcaacac      600

ataccataca gagaagataa aaacctcact ggcactgccc gatatgctag catcaatgca      660

catcttggta ttgagcagag tcgccgagat gacatggaat cattaggata tgttttgatg      720

tattttaata gaaccagcct gccatggcaa gggctaaagg ctgcaacaaa aaaaaaaaaa      780

aaaaa                                                                  785


<210>  68
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  68

Met Ala Ser Ser Ser Gly Ser Lys Ala Glu Phe Ile Val Gly Gly Lys 
1               5                   10                  15      


Tyr Lys Leu Val Arg Lys Ile Gly Ser Gly Ser Phe Gly Asp Ile Tyr 
            20                  25                  30          


Leu Ala Ile Asn Ile Thr Asn Gly Glu Glu Val Ala Val Lys Leu Glu 
        35                  40                  45              


Ser Gln Lys Ala Arg His Pro Gln Leu Leu Tyr Glu Ser Lys Leu Tyr 
    50                  55                  60                  


Lys Ile Leu Gln Gly Gly Val Gly Ile Pro His Ile Arg Trp Tyr Gly 
65                  70                  75                  80  


Gln Glu Lys Asp Tyr Asn Val Leu Val Met Asp Leu Leu Gly Pro Ser 
                85                  90                  95      


Leu Glu Asp Leu Phe Asn Phe Cys Ser Arg Arg Phe Thr Met Lys Thr 
            100                 105                 110         


Val Leu Met Leu Ala Asp Gln Met Ile Ser Arg Ile Glu Tyr Val His 
        115                 120                 125             


Thr Lys Asn Phe Ile His Arg Asp Ile Lys Pro Asp Asn Phe Leu Met 
    130                 135                 140                 


Gly Ile Gly Arg His Cys Asn Lys Cys Leu Glu Ser Pro Val Gly Lys 
145                 150                 155                 160 


Arg Lys Arg Ser Met Thr Val Ser Thr Ser Gln Asp Pro Ser Phe Ser 
                165                 170                 175     


Gly Leu Asn Gln Leu Phe Leu Ile Asp Phe Gly Leu Ala Lys Lys Tyr 
            180                 185                 190         


Arg Asp Asn Arg Thr Arg Gln His Ile Pro Tyr Arg Glu Asp Lys Asn 
        195                 200                 205             


Leu Thr Gly Thr Ala Arg Tyr Ala Ser Ile Asn Ala His Leu Gly Ile 
    210                 215                 220                 


Glu Gln Ser Arg Arg Asp Asp Met Glu Ser Leu Gly Tyr Val Leu Met 
225                 230                 235                 240 


Tyr Phe Asn Arg Thr Ser Leu Pro Trp Gln Gly Leu Lys Ala Ala Thr 
                245                 250                 255     


Lys Lys Lys Lys Lys 
            260     


<210>  69
<211>  582
<212>  DNA
<213>  Homo sapiens

<400>  69
atgccgaact ggggaggagg caagaaatgt ggggtgtgtc agaagacggt ttactttgcc       60

gaagaggttc agtgcgaagg caacagcttc cataaatcct gcttcctgtg catggtctgc      120

aagaagaatc tggacagtac cactgtggcc gtgcatggtg aggagattta ctgcaagtcc      180

tgctacggca agaagtatgg gcccaaaggc tatggctacg ggcagggcgc aggcaccctc      240

agcactgaca agggggagtc gctgggtatc aagcacgagg aagcccctgg ccacaggccc      300

accaccaacc ccaatgcatc caaatttgcc cagaagattg gtggctccga gcgctgcccc      360

cgatgcagcc aggcagtcta tgctgcggag aaggtgattg gtgctgggaa gtcctggcat      420

aaggcctgct ttcgatgtgc caagtgtggc aaaggccttg agtcaaccac cctggcagac      480

aaggatggcg agatttactg caaaggatgt tatgctaaaa acttcgggcc caagggcttt      540

ggttttgggc aaggagctgg ggccttggtc cactctgagt ga                         582


<210>  70
<211>  193
<212>  PRT
<213>  Homo sapiens

<400>  70

Met Pro Asn Trp Gly Gly Gly Lys Lys Cys Gly Val Cys Gln Lys Thr 
1               5                   10                  15      


Val Tyr Phe Ala Glu Glu Val Gln Cys Glu Gly Asn Ser Phe His Lys 
            20                  25                  30          


Ser Cys Phe Leu Cys Met Val Cys Lys Lys Asn Leu Asp Ser Thr Thr 
        35                  40                  45              


Val Ala Val His Gly Glu Glu Ile Tyr Cys Lys Ser Cys Tyr Gly Lys 
    50                  55                  60                  


Lys Tyr Gly Pro Lys Gly Tyr Gly Tyr Gly Gln Gly Ala Gly Thr Leu 
65                  70                  75                  80  


Ser Thr Asp Lys Gly Glu Ser Leu Gly Ile Lys His Glu Glu Ala Pro 
                85                  90                  95      


Gly His Arg Pro Thr Thr Asn Pro Asn Ala Ser Lys Phe Ala Gln Lys 
            100                 105                 110         


Ile Gly Gly Ser Glu Arg Cys Pro Arg Cys Ser Gln Ala Val Tyr Ala 
        115                 120                 125             


Ala Glu Lys Val Ile Gly Ala Gly Lys Ser Trp His Lys Ala Cys Phe 
    130                 135                 140                 


Arg Cys Ala Lys Cys Gly Lys Gly Leu Glu Ser Thr Thr Leu Ala Asp 
145                 150                 155                 160 


Lys Asp Gly Glu Ile Tyr Cys Lys Gly Cys Tyr Ala Lys Asn Phe Gly 
                165                 170                 175     


Pro Lys Gly Phe Gly Phe Gly Gln Gly Ala Gly Ala Leu Val His Ser 
            180                 185                 190         


Glu 
    


<210>  71
<211>  996
<212>  DNA
<213>  Homo sapiens

<400>  71
atggaggtga ccggggacgc cggggtacca gaatctggcg agatccggac tctaaagccg       60

tgtctgctgc gccgcaacta cagccgcgaa cagcacggcg tggccgcctc ctgcctcgaa      120

gacctgagga gcaaggcctg tgacattctg gccattgata agtccctgac accagtcacc      180

ctggtcctgg cagaggatgg caccatagtg gatgatgacg attactttct gtgtctacct      240

tccaatacta agtttgtggc attggctagt aatgagaaat gggcatacaa caattcagat      300

ggaggtacag cttggatttc ccaagagtcc tttgatgtag atgaaacaga cagcggggca      360

gggttgaagt ggaagaatgt ggccaggcag ctgaaagaag atctgtccag catcatcctc      420

ctatcagagg aggacctcca gatgcttgtt gacgctccct gctcagacct ggctcaggaa      480

ctacgtcaga gttgtgccac cgtccagcgg ctgcagcaca cactccaaca ggtgcttgac      540

caaagagagg aagtgcgtca gtccaagcag ctcctgcagc tgtacctcca ggctttggag      600

aaagagggca gcctcttgtc aaagcaggaa gagtccaaag ctgcctttgg tgaggaggtg      660

gatgcagtag acacgggtat cagcagagag acctcctcgg acgttgcgct ggcgagccac      720

atccttactg cactgaggga gaagcaggct ccagagctga gcttatctag tcaggatttg      780

gagttggtta ccaaggaaga ccccaaagca ctggctgttg ccttgaactg ggacataaag      840

aagacggaga ctgttcagga ggcctgtgag cgggagctcg ccctgcgcct gcagcagacg      900

cagagcttgc attctctccg gagcatctca gcaagcaagg cctcaccacc tggtgacctg      960

cagaatccta agcgagccag acaggatccc acatag                                996


<210>  72
<211>  331
<212>  PRT
<213>  Homo sapiens

<400>  72

Met Glu Val Thr Gly Asp Ala Gly Val Pro Glu Ser Gly Glu Ile Arg 
1               5                   10                  15      


Thr Leu Lys Pro Cys Leu Leu Arg Arg Asn Tyr Ser Arg Glu Gln His 
            20                  25                  30          


Gly Val Ala Ala Ser Cys Leu Glu Asp Leu Arg Ser Lys Ala Cys Asp 
        35                  40                  45              


Ile Leu Ala Ile Asp Lys Ser Leu Thr Pro Val Thr Leu Val Leu Ala 
    50                  55                  60                  


Glu Asp Gly Thr Ile Val Asp Asp Asp Asp Tyr Phe Leu Cys Leu Pro 
65                  70                  75                  80  


Ser Asn Thr Lys Phe Val Ala Leu Ala Ser Asn Glu Lys Trp Ala Tyr 
                85                  90                  95      


Asn Asn Ser Asp Gly Gly Thr Ala Trp Ile Ser Gln Glu Ser Phe Asp 
            100                 105                 110         


Val Asp Glu Thr Asp Ser Gly Ala Gly Leu Lys Trp Lys Asn Val Ala 
        115                 120                 125             


Arg Gln Leu Lys Glu Asp Leu Ser Ser Ile Ile Leu Leu Ser Glu Glu 
    130                 135                 140                 


Asp Leu Gln Met Leu Val Asp Ala Pro Cys Ser Asp Leu Ala Gln Glu 
145                 150                 155                 160 


Leu Arg Gln Ser Cys Ala Thr Val Gln Arg Leu Gln His Thr Leu Gln 
                165                 170                 175     


Gln Val Leu Asp Gln Arg Glu Glu Val Arg Gln Ser Lys Gln Leu Leu 
            180                 185                 190         


Gln Leu Tyr Leu Gln Ala Leu Glu Lys Glu Gly Ser Leu Leu Ser Lys 
        195                 200                 205             


Gln Glu Glu Ser Lys Ala Ala Phe Gly Glu Glu Val Asp Ala Val Asp 
    210                 215                 220                 


Thr Gly Ile Ser Arg Glu Thr Ser Ser Asp Val Ala Leu Ala Ser His 
225                 230                 235                 240 


Ile Leu Thr Ala Leu Arg Glu Lys Gln Ala Pro Glu Leu Ser Leu Ser 
                245                 250                 255     


Ser Gln Asp Leu Glu Leu Val Thr Lys Glu Asp Pro Lys Ala Leu Ala 
            260                 265                 270         


Val Ala Leu Asn Trp Asp Ile Lys Lys Thr Glu Thr Val Gln Glu Ala 
        275                 280                 285             


Cys Glu Arg Glu Leu Ala Leu Arg Leu Gln Gln Thr Gln Ser Leu His 
    290                 295                 300                 


Ser Leu Arg Ser Ile Ser Ala Ser Lys Ala Ser Pro Pro Gly Asp Leu 
305                 310                 315                 320 


Gln Asn Pro Lys Arg Ala Arg Gln Asp Pro Thr 
                325                 330     


<210>  73
<211>  1284
<212>  DNA
<213>  Homo sapiens

<400>  73
atggaaaccc tttgcctcag ggcatccttt tggctggcac tggttggatg tgtaatcagt       60

gataatcctg agagatacag cacaaatcta agcaatcatg tggatgattt caccactttt      120

cgtggcacag agctcagctt cctggttacc actcatcaac ccactaattt ggtcctaccc      180

agcaatggct caatgcacaa ctattgccca cagcagacta aaattacttc agctttcaaa      240

tacattaaca ctgtgatatc ttgtactatt ttcatcgtgg gaatggtggg gaatgcaact      300

ctgctcagga tcatttacca gaacaaatgt atgaggaatg gccccaacgc gctgatagcc      360

agtcttgccc ttggagacct tatctatgtg gtcattgatc tccctatcaa tgtatttaag      420

ctgctggctg ggcgctggcc ttttgatcac aatgactttg gcgtatttct ttgcaagctg      480

ttcccctttt tgcagaagtc ctcggtgggg atcaccgtcc tcaacctctg cgctcttagt      540

gttgacaggt acagagcagt tgcctcctgg agtcgtgttc agggaattgg gattcctttg      600

gtaactgcca ttgaaattgt ctccatctgg atcctgtcct ttatcctggc cattcctgaa      660

gcgattggct tcgtcatggt accctttgaa tataggggtg aacagcataa aacctgtatg      720

ctcaatgcca catcaaaatt catggagttc taccaagatg taaaggactg gtggctcttc      780

gggttctatt tctgtatgcc cttggtgtgc actgcgatct tctacaccct catgacttgt      840

gagatgttga acagaaggaa tggcagcttg agaattgccc tcagtgaaca tcttaagcag      900

cgtcgagaag tggcaaaaac agttttctgc ttggttgtaa tttttgctct ttgctggttc      960

cctcttcatt taagccgtat attgaagaaa actgtgtata acgagatgga caagaaccga     1020

tgtgaattac ttagtttctt actgctcatg gattacatcg gtattaactt ggcaaccatg     1080

aattcatgta taaaccccat agctctgtat tttgtgagca agaaatttaa aaattgtttc     1140

cagtcatgcc tctgctgctg ctgttaccag tccaaaagtc tgatgacctc ggtccccatg     1200

aacggaacaa gcatccagtg gaagaaccac gatcaaaaca accacaacac agaccggagc     1260

agccataagg acagcatgaa ctga                                            1284


<210>  74
<211>  427
<212>  PRT
<213>  Homo sapiens

<400>  74

Met Glu Thr Leu Cys Leu Arg Ala Ser Phe Trp Leu Ala Leu Val Gly 
1               5                   10                  15      


Cys Val Ile Ser Asp Asn Pro Glu Arg Tyr Ser Thr Asn Leu Ser Asn 
            20                  25                  30          


His Val Asp Asp Phe Thr Thr Phe Arg Gly Thr Glu Leu Ser Phe Leu 
        35                  40                  45              


Val Thr Thr His Gln Pro Thr Asn Leu Val Leu Pro Ser Asn Gly Ser 
    50                  55                  60                  


Met His Asn Tyr Cys Pro Gln Gln Thr Lys Ile Thr Ser Ala Phe Lys 
65                  70                  75                  80  


Tyr Ile Asn Thr Val Ile Ser Cys Thr Ile Phe Ile Val Gly Met Val 
                85                  90                  95      


Gly Asn Ala Thr Leu Leu Arg Ile Ile Tyr Gln Asn Lys Cys Met Arg 
            100                 105                 110         


Asn Gly Pro Asn Ala Leu Ile Ala Ser Leu Ala Leu Gly Asp Leu Ile 
        115                 120                 125             


Tyr Val Val Ile Asp Leu Pro Ile Asn Val Phe Lys Leu Leu Ala Gly 
    130                 135                 140                 


Arg Trp Pro Phe Asp His Asn Asp Phe Gly Val Phe Leu Cys Lys Leu 
145                 150                 155                 160 


Phe Pro Phe Leu Gln Lys Ser Ser Val Gly Ile Thr Val Leu Asn Leu 
                165                 170                 175     


Cys Ala Leu Ser Val Asp Arg Tyr Arg Ala Val Ala Ser Trp Ser Arg 
            180                 185                 190         


Val Gln Gly Ile Gly Ile Pro Leu Val Thr Ala Ile Glu Ile Val Ser 
        195                 200                 205             


Ile Trp Ile Leu Ser Phe Ile Leu Ala Ile Pro Glu Ala Ile Gly Phe 
    210                 215                 220                 


Val Met Val Pro Phe Glu Tyr Arg Gly Glu Gln His Lys Thr Cys Met 
225                 230                 235                 240 


Leu Asn Ala Thr Ser Lys Phe Met Glu Phe Tyr Gln Asp Val Lys Asp 
                245                 250                 255     


Trp Trp Leu Phe Gly Phe Tyr Phe Cys Met Pro Leu Val Cys Thr Ala 
            260                 265                 270         


Ile Phe Tyr Thr Leu Met Thr Cys Glu Met Leu Asn Arg Arg Asn Gly 
        275                 280                 285             


Ser Leu Arg Ile Ala Leu Ser Glu His Leu Lys Gln Arg Arg Glu Val 
    290                 295                 300                 


Ala Lys Thr Val Phe Cys Leu Val Val Ile Phe Ala Leu Cys Trp Phe 
305                 310                 315                 320 


Pro Leu His Leu Ser Arg Ile Leu Lys Lys Thr Val Tyr Asn Glu Met 
                325                 330                 335     


Asp Lys Asn Arg Cys Glu Leu Leu Ser Phe Leu Leu Leu Met Asp Tyr 
            340                 345                 350         


Ile Gly Ile Asn Leu Ala Thr Met Asn Ser Cys Ile Asn Pro Ile Ala 
        355                 360                 365             


Leu Tyr Phe Val Ser Lys Lys Phe Lys Asn Cys Phe Gln Ser Cys Leu 
    370                 375                 380                 


Cys Cys Cys Cys Tyr Gln Ser Lys Ser Leu Met Thr Ser Val Pro Met 
385                 390                 395                 400 


Asn Gly Thr Ser Ile Gln Trp Lys Asn His Asp Gln Asn Asn His Asn 
                405                 410                 415     


Thr Asp Arg Ser Ser His Lys Asp Ser Met Asn 
            420                 425         


<210>  75
<211>  1686
<212>  DNA
<213>  Homo sapiens

<400>  75
atggccattg ccacgtcgac ccagctggcc cgggcactgt atgacaacac cgctgagtcc       60

ccccaggagc tgtccttccg ccgaggggat gtcctacggg tcctgcagag agagggcgct      120

ggtggactgg acggctggtg cctctgctcc ctacacggcc agcagggcat tgtgcccgcc      180

aacagggtga agctcttgcc tgctggccca gcacccaagc ccagcctctc tcctgcgtcc      240

ccagcccagc ctggctcacc atatccagcc ccagatcaca gcaatgagga ccaggaggtg      300

tatgtggtgc cgcccccagc tcggccctgt ccaacctcag gacctccagc tggaccttgc      360

ccaccctctc ctgacctcat ctacaaaatc cccagagcta gtgggaccca gctggctgct      420

cccagagatg ccttggaggt ctacgatgtg ccccccaccg ccctccgggt gccctccagt      480

ggcccctatg actgccctgc ctccttttcc caccctctga cccgggttgc cccgcagccc      540

cctggagagg atgatgctcc ctatgatgtg cctctgaccc caaagccacc tgcagagctg      600

gaaccagatc tggagtggga aggaggccgg gagccggggc cccccatcta tgctgccccc      660

tccaacctga aacgagcgtc agccttactc aatttgtatg aagcacccga ggaactgctg      720

gcagacgggg agggcggggg cactgatgag gggatctacg atgtgcctct gctggggcca      780

gaggctcccc cttctccaga gccccctgga gccttggcct cccatgacca ggacaccctg      840

gcccagcttc tggccagaag ccccccaccc ccacacaggc cccggctccc ctcagctgag      900

agcctgtccc gccgccctct gcctgccctg cctgtccctg aggcccccag cccctcccca      960

gtgccctctc ctgccccagg ccggaagggc agcatccagg accggcctct gcccccaccc     1020

ccaccccgcc tgcctggtta tggaggcccc aaggtcgagg gggatccaga gggcagggag     1080

atggaggatg acccagcagg acaccacaat gagtacgagg gcattccgat ggccgaggag     1140

tatgactatg tccacctgaa gggcatggac aaagctcagg gatctaggcc cccggatcag     1200

gcctgcacag gggatcctga actgcccgag agggggatgc cggcgccgca ggaggccctg     1260

tccccagggg agccactggt tgtgtccacc ggagatctgc agctcctgta cttctatgct     1320

gggcaatgcc agagccacta ctcagccctg caggcagccg tggcagccct gatgtccagt     1380

acccaggcta atcagccccc gcgccttttc gtgccccaca gcaagagggt ggtggtggct     1440

gctcatcgcc tggtgtttgt tggggacacc ctgggccggc tggcagcctc tgcccctctg     1500

agagcacagg tcagggctgc aggtacagca ctgggccagg cattgcgggc cactgtgctg     1560

gctgtcaagg gagctgccct gggctaccca tccagccctg ccatccaaga gatggtgcag     1620

tgtgtaacag aactggcagg gcaggccctg caattcacta ccctgctcac tagcctggct     1680

ccatga                                                                1686


<210>  76
<211>  561
<212>  PRT
<213>  Homo sapiens

<400>  76

Met Ala Ile Ala Thr Ser Thr Gln Leu Ala Arg Ala Leu Tyr Asp Asn 
1               5                   10                  15      


Thr Ala Glu Ser Pro Gln Glu Leu Ser Phe Arg Arg Gly Asp Val Leu 
            20                  25                  30          


Arg Val Leu Gln Arg Glu Gly Ala Gly Gly Leu Asp Gly Trp Cys Leu 
        35                  40                  45              


Cys Ser Leu His Gly Gln Gln Gly Ile Val Pro Ala Asn Arg Val Lys 
    50                  55                  60                  


Leu Leu Pro Ala Gly Pro Ala Pro Lys Pro Ser Leu Ser Pro Ala Ser 
65                  70                  75                  80  


Pro Ala Gln Pro Gly Ser Pro Tyr Pro Ala Pro Asp His Ser Asn Glu 
                85                  90                  95      


Asp Gln Glu Val Tyr Val Val Pro Pro Pro Ala Arg Pro Cys Pro Thr 
            100                 105                 110         


Ser Gly Pro Pro Ala Gly Pro Cys Pro Pro Ser Pro Asp Leu Ile Tyr 
        115                 120                 125             


Lys Ile Pro Arg Ala Ser Gly Thr Gln Leu Ala Ala Pro Arg Asp Ala 
    130                 135                 140                 


Leu Glu Val Tyr Asp Val Pro Pro Thr Ala Leu Arg Val Pro Ser Ser 
145                 150                 155                 160 


Gly Pro Tyr Asp Cys Pro Ala Ser Phe Ser His Pro Leu Thr Arg Val 
                165                 170                 175     


Ala Pro Gln Pro Pro Gly Glu Asp Asp Ala Pro Tyr Asp Val Pro Leu 
            180                 185                 190         


Thr Pro Lys Pro Pro Ala Glu Leu Glu Pro Asp Leu Glu Trp Glu Gly 
        195                 200                 205             


Gly Arg Glu Pro Gly Pro Pro Ile Tyr Ala Ala Pro Ser Asn Leu Lys 
    210                 215                 220                 


Arg Ala Ser Ala Leu Leu Asn Leu Tyr Glu Ala Pro Glu Glu Leu Leu 
225                 230                 235                 240 


Ala Asp Gly Glu Gly Gly Gly Thr Asp Glu Gly Ile Tyr Asp Val Pro 
                245                 250                 255     


Leu Leu Gly Pro Glu Ala Pro Pro Ser Pro Glu Pro Pro Gly Ala Leu 
            260                 265                 270         


Ala Ser His Asp Gln Asp Thr Leu Ala Gln Leu Leu Ala Arg Ser Pro 
        275                 280                 285             


Pro Pro Pro His Arg Pro Arg Leu Pro Ser Ala Glu Ser Leu Ser Arg 
    290                 295                 300                 


Arg Pro Leu Pro Ala Leu Pro Val Pro Glu Ala Pro Ser Pro Ser Pro 
305                 310                 315                 320 


Val Pro Ser Pro Ala Pro Gly Arg Lys Gly Ser Ile Gln Asp Arg Pro 
                325                 330                 335     


Leu Pro Pro Pro Pro Pro Arg Leu Pro Gly Tyr Gly Gly Pro Lys Val 
            340                 345                 350         


Glu Gly Asp Pro Glu Gly Arg Glu Met Glu Asp Asp Pro Ala Gly His 
        355                 360                 365             


His Asn Glu Tyr Glu Gly Ile Pro Met Ala Glu Glu Tyr Asp Tyr Val 
    370                 375                 380                 


His Leu Lys Gly Met Asp Lys Ala Gln Gly Ser Arg Pro Pro Asp Gln 
385                 390                 395                 400 


Ala Cys Thr Gly Asp Pro Glu Leu Pro Glu Arg Gly Met Pro Ala Pro 
                405                 410                 415     


Gln Glu Ala Leu Ser Pro Gly Glu Pro Leu Val Val Ser Thr Gly Asp 
            420                 425                 430         


Leu Gln Leu Leu Tyr Phe Tyr Ala Gly Gln Cys Gln Ser His Tyr Ser 
        435                 440                 445             


Ala Leu Gln Ala Ala Val Ala Ala Leu Met Ser Ser Thr Gln Ala Asn 
    450                 455                 460                 


Gln Pro Pro Arg Leu Phe Val Pro His Ser Lys Arg Val Val Val Ala 
465                 470                 475                 480 


Ala His Arg Leu Val Phe Val Gly Asp Thr Leu Gly Arg Leu Ala Ala 
                485                 490                 495     


Ser Ala Pro Leu Arg Ala Gln Val Arg Ala Ala Gly Thr Ala Leu Gly 
            500                 505                 510         


Gln Ala Leu Arg Ala Thr Val Leu Ala Val Lys Gly Ala Ala Leu Gly 
        515                 520                 525             


Tyr Pro Ser Ser Pro Ala Ile Gln Glu Met Val Gln Cys Val Thr Glu 
    530                 535                 540                 


Leu Ala Gly Gln Ala Leu Gln Phe Thr Thr Leu Leu Thr Ser Leu Ala 
545                 550                 555                 560 


Pro 
    


<210>  77
<211>  2280
<212>  DNA
<213>  Homo sapiens

<400>  77
atggaatcat ctccatttaa tagacggcaa tggacctcac tatcattgag ggtaacagcc       60

aaagaacttt ctcttgtcaa caagaacaag tcatcggcta ttgtggaaat attctccaag      120

taccagaaag cagctgaaga aacaaacatg gagaagaaga gaagtaacac cgaaaatctc      180

tcccagcact ttagaaaggg gaccctgact gtgttaaaga agaagtggga gaacccaggg      240

ctgggagcag agtctcacac agactctcta cggaacagca gcactgagat taggcacaga      300

gcagaccatc ctcctgctga agtgacaagc cacgctgctt ctggagccaa agctgaccaa      360

gaagaacaaa tccaccccag atctagactc aggtcacctc ctgaagccct cgttcagggt      420

cgatatcccc acatcaagga cggtgaggat cttaaagacc actcaacaga aagtaaaaaa      480

atggaaaatt gtctaggaga atccaggcat gaagtagaaa aatcagaaat cagtgaaaac      540

acagatgctt cgggcaaaat agagaaatat aatgttccgc tgaacaggct taagatgatg      600

tttgagaaag gtgaaccaac tcaaactaag attctccggg cccaaagccg aagtgcaagt      660

ggaaggaaga tctctgaaaa cagctattct ctagatgacc tggaaatagg cccaggtcag      720

ttgtcatctt ctacatttga ctcggagaaa aatgagagta gacgaaatct ggaacttcca      780

cgcctctcag aaacctctat aaaggatcga atggccaagt accaggcagc tgtgtccaaa      840

caaagcagct caaccaacta tacaaatgag ctgaaagcca gtggtggcga aatcaaaatt      900

cataaaatgg agcaaaagga gaatgtgccc ccaggtcctg aggtctgcat cacccatcag      960

gaaggggaaa agatttctgc aaatgagaat agcctggcag tccgttccac ccctgccgaa     1020

gatgactccc gtgactccca ggttaagagt gaggttcaac agcctgtcca tcccaagcca     1080

ctaagtccag attccagagc ctccagtctt tctgaaagtt ctcctcccaa agcaatgaag     1140

aagtttcagg cacctgcaag agagacctgc gtggaatgtc agaagacagt ctatccaatg     1200

gagcgtctct tggccaacca gcaggtgttt cacatcagct gcttccgttg ctcctattgc     1260

aacaacaaac tcagtctagg aacatatgca tctttacatg gaagaatcta ttgtaagcct     1320

cacttcaatc aactctttaa atctaagggc aactatgatg aaggctttgg gcacagacca     1380

cacaaggatc tatgggcaag caaaaatgaa aacgaagaga ttttggagag accagcccag     1440

cttgcaaatg caagggagac ccctcacagc ccaggggtag aagatgcccc tattgctaag     1500

gtgggtgtcc tggctgcaag tatggaagcc aaggcctcct ctcagcagga gaaggaagac     1560

aagccagctg aaaccaagaa gctgaggatc gcctggccac cccccactga acttggaagt     1620

tcaggaagtg ccttggagga agggatcaaa atgtcaaagc ccaaatggcc tcctgaagac     1680

gaaatcagca agcccgaagt tcctgaggat gtcgatctag atctgaagaa gctaagacga     1740

tcttcttcac tgaaggaaag aagccgccca ttcactgtag cagcttcatt tcaaagcacc     1800

tctgtcaaga gcccaaaaac tgtgtcccca cctatcagga aaggctggag catgtcagag     1860

cagagtgaag agtctgtggg tggaagagtt gcagaaagga aacaagtgga aaatgccaag     1920

gcttctaaga agaatgggaa tgtgggaaaa acaacctggc aaaacaaaga atctaaagga     1980

gagacaggga agagaagtaa ggaaggtcat agtttggaga tggagaatga gaatcttgta     2040

gaaaatggtg cagactccga tgaagatgat aacagcttcc tcaaacaaca atctccacaa     2100

gaacccaagt ctctgaattg gtcgagtttt gtagacaaca cctttgctga agaattcact     2160

actcagaatc agaaatccca ggatgtggaa ctctgggagg gagaagtggt caaagagctc     2220

tctgtggaag aacagataaa gagaaatcgg tattatgatg aggatgagga tgaagagtga     2280


<210>  78
<211>  759
<212>  PRT
<213>  Homo sapiens

<400>  78

Met Glu Ser Ser Pro Phe Asn Arg Arg Gln Trp Thr Ser Leu Ser Leu 
1               5                   10                  15      


Arg Val Thr Ala Lys Glu Leu Ser Leu Val Asn Lys Asn Lys Ser Ser 
            20                  25                  30          


Ala Ile Val Glu Ile Phe Ser Lys Tyr Gln Lys Ala Ala Glu Glu Thr 
        35                  40                  45              


Asn Met Glu Lys Lys Arg Ser Asn Thr Glu Asn Leu Ser Gln His Phe 
    50                  55                  60                  


Arg Lys Gly Thr Leu Thr Val Leu Lys Lys Lys Trp Glu Asn Pro Gly 
65                  70                  75                  80  


Leu Gly Ala Glu Ser His Thr Asp Ser Leu Arg Asn Ser Ser Thr Glu 
                85                  90                  95      


Ile Arg His Arg Ala Asp His Pro Pro Ala Glu Val Thr Ser His Ala 
            100                 105                 110         


Ala Ser Gly Ala Lys Ala Asp Gln Glu Glu Gln Ile His Pro Arg Ser 
        115                 120                 125             


Arg Leu Arg Ser Pro Pro Glu Ala Leu Val Gln Gly Arg Tyr Pro His 
    130                 135                 140                 


Ile Lys Asp Gly Glu Asp Leu Lys Asp His Ser Thr Glu Ser Lys Lys 
145                 150                 155                 160 


Met Glu Asn Cys Leu Gly Glu Ser Arg His Glu Val Glu Lys Ser Glu 
                165                 170                 175     


Ile Ser Glu Asn Thr Asp Ala Ser Gly Lys Ile Glu Lys Tyr Asn Val 
            180                 185                 190         


Pro Leu Asn Arg Leu Lys Met Met Phe Glu Lys Gly Glu Pro Thr Gln 
        195                 200                 205             


Thr Lys Ile Leu Arg Ala Gln Ser Arg Ser Ala Ser Gly Arg Lys Ile 
    210                 215                 220                 


Ser Glu Asn Ser Tyr Ser Leu Asp Asp Leu Glu Ile Gly Pro Gly Gln 
225                 230                 235                 240 


Leu Ser Ser Ser Thr Phe Asp Ser Glu Lys Asn Glu Ser Arg Arg Asn 
                245                 250                 255     


Leu Glu Leu Pro Arg Leu Ser Glu Thr Ser Ile Lys Asp Arg Met Ala 
            260                 265                 270         


Lys Tyr Gln Ala Ala Val Ser Lys Gln Ser Ser Ser Thr Asn Tyr Thr 
        275                 280                 285             


Asn Glu Leu Lys Ala Ser Gly Gly Glu Ile Lys Ile His Lys Met Glu 
    290                 295                 300                 


Gln Lys Glu Asn Val Pro Pro Gly Pro Glu Val Cys Ile Thr His Gln 
305                 310                 315                 320 


Glu Gly Glu Lys Ile Ser Ala Asn Glu Asn Ser Leu Ala Val Arg Ser 
                325                 330                 335     


Thr Pro Ala Glu Asp Asp Ser Arg Asp Ser Gln Val Lys Ser Glu Val 
            340                 345                 350         


Gln Gln Pro Val His Pro Lys Pro Leu Ser Pro Asp Ser Arg Ala Ser 
        355                 360                 365             


Ser Leu Ser Glu Ser Ser Pro Pro Lys Ala Met Lys Lys Phe Gln Ala 
    370                 375                 380                 


Pro Ala Arg Glu Thr Cys Val Glu Cys Gln Lys Thr Val Tyr Pro Met 
385                 390                 395                 400 


Glu Arg Leu Leu Ala Asn Gln Gln Val Phe His Ile Ser Cys Phe Arg 
                405                 410                 415     


Cys Ser Tyr Cys Asn Asn Lys Leu Ser Leu Gly Thr Tyr Ala Ser Leu 
            420                 425                 430         


His Gly Arg Ile Tyr Cys Lys Pro His Phe Asn Gln Leu Phe Lys Ser 
        435                 440                 445             


Lys Gly Asn Tyr Asp Glu Gly Phe Gly His Arg Pro His Lys Asp Leu 
    450                 455                 460                 


Trp Ala Ser Lys Asn Glu Asn Glu Glu Ile Leu Glu Arg Pro Ala Gln 
465                 470                 475                 480 


Leu Ala Asn Ala Arg Glu Thr Pro His Ser Pro Gly Val Glu Asp Ala 
                485                 490                 495     


Pro Ile Ala Lys Val Gly Val Leu Ala Ala Ser Met Glu Ala Lys Ala 
            500                 505                 510         


Ser Ser Gln Gln Glu Lys Glu Asp Lys Pro Ala Glu Thr Lys Lys Leu 
        515                 520                 525             


Arg Ile Ala Trp Pro Pro Pro Thr Glu Leu Gly Ser Ser Gly Ser Ala 
    530                 535                 540                 


Leu Glu Glu Gly Ile Lys Met Ser Lys Pro Lys Trp Pro Pro Glu Asp 
545                 550                 555                 560 


Glu Ile Ser Lys Pro Glu Val Pro Glu Asp Val Asp Leu Asp Leu Lys 
                565                 570                 575     


Lys Leu Arg Arg Ser Ser Ser Leu Lys Glu Arg Ser Arg Pro Phe Thr 
            580                 585                 590         


Val Ala Ala Ser Phe Gln Ser Thr Ser Val Lys Ser Pro Lys Thr Val 
        595                 600                 605             


Ser Pro Pro Ile Arg Lys Gly Trp Ser Met Ser Glu Gln Ser Glu Glu 
    610                 615                 620                 


Ser Val Gly Gly Arg Val Ala Glu Arg Lys Gln Val Glu Asn Ala Lys 
625                 630                 635                 640 


Ala Ser Lys Lys Asn Gly Asn Val Gly Lys Thr Thr Trp Gln Asn Lys 
                645                 650                 655     


Glu Ser Lys Gly Glu Thr Gly Lys Arg Ser Lys Glu Gly His Ser Leu 
            660                 665                 670         


Glu Met Glu Asn Glu Asn Leu Val Glu Asn Gly Ala Asp Ser Asp Glu 
        675                 680                 685             


Asp Asp Asn Ser Phe Leu Lys Gln Gln Ser Pro Gln Glu Pro Lys Ser 
    690                 695                 700                 


Leu Asn Trp Ser Ser Phe Val Asp Asn Thr Phe Ala Glu Glu Phe Thr 
705                 710                 715                 720 


Thr Gln Asn Gln Lys Ser Gln Asp Val Glu Leu Trp Glu Gly Glu Val 
                725                 730                 735     


Val Lys Glu Leu Ser Val Glu Glu Gln Ile Lys Arg Asn Arg Tyr Tyr 
            740                 745                 750         


Asp Glu Asp Glu Asp Glu Glu 
        755                 


<210>  79
<211>  2469
<212>  DNA
<213>  Homo sapiens

<400>  79
atgaatggtc atatttctaa tcatcccagt agttttggaa tgtacccatc tcagatgaat       60

ggctacggat catcacctac cttttcccag acggacagag aacatggttc aaaaacaagt      120

gcaaaggccc tttatgaaca aaggaagaat tatgcacggg acagtgtcag cagtgtgtca      180

gatatatctc aataccgtgt tgaacacttg actacctttg tcctggatcg gaaagatgct      240

atgatcactg ttgatgatgg aataaggaaa ttgaaattgc ttgatgccaa gggcaaagtg      300

tggactcaag atatgattct tcaagtggat gacagagctg tgagcctgat tgatttagaa      360

tcaaagaatg aactggagaa ttttccttta aacacaatcc agcactgcca agctgtgatg      420

cattcatgca gctatgattc agttcttgca ctggtgtgca aagagccaac ccagaacaag      480

ccagatcttc atctcttcca gtgtgatgag gttaaggcaa acctaattag tgaagatatt      540

gaaagtgcaa tcagtgacag taaaggaggg aaacagaaga ggcggcccga cgccctgagg      600

atgatttcca atgcagaccc tagtataccg cctccaccca gagctcctgc ccctgcgccc      660

cctgggaccg tcacccaggt ggatgttaga agtcgagtgg cagcctggtc tgcatgggca      720

gccgaccaag gggactttga gaaaccaagg cagtatcatg agcaggaaga aacacctgag      780

atgatggcag cccgcattga cagagatgtg caaatcttaa accacatttt ggatgacatt      840

gaatttttta tcacaaaact ccaaaaagca gcagaagcat tttctgagct ttctaaaagg      900

aagaaaaaca agaaaggtaa aaggaaagga ccaggagagg gtgttttaac gctgcgggca      960

aaacctccac ctcctgatga atttcttgac tgtttccaaa agtttaaaca cggatttaac     1020

cttctggcca aactgaagtc tcatattcag aatcctagtg ctgcagattt ggttcacttt     1080

ttgtttactc cattaaatat ggtggtgcag gcaacaggag gtcctgaact agccagttca     1140

gtacttagtc ccctattgaa taaggacaca attgatttct taaattatac tgtcaatggt     1200

gatgaacggc agctgtggat gtcattggga ggaacttgga tgaaagccag agcagagtgg     1260

ccaaaagaac agtttattcc accatatgtt ccacgattcc gcaatggctg ggagccccca     1320

atgctgaact ttatgggagc cacaatggaa caagatcttt atcaactggc agaatctgtg     1380

gcaaatgtag cagaacatca gcgcaaacag gaaataaaaa gattatccac agagcattcc     1440

agtgtatcag agtatcatcc agccgatggc tatgcgttca gtagcaacat ttacacaaga     1500

ggatcccacc tggaccaagg ggaagctgct gttgctttta agccaacttc taatcgccat     1560

atagatagaa attatgaacc actcaaaaca caacccaaga aatatgccaa atccaagtat     1620

gactttgtag caaggaacaa cagtgagctc tcggttctaa aggatgatat tttagagata     1680

cttgatgatc ggaagcaatg gtggaaagtt cgaaatgcaa gtggagactc tggatttgtg     1740

ccaaataaca ttttggatat tgtgagacct ccagaatctg gattggggcg tgctgatcca     1800

ccttatactc atactataca gaaacaaagg atggagtatg gcccaagacc agctgatact     1860

ccccctgctc catcacctcc tccaacacca gctcctgttc ctgttcccct tcccccttcc     1920

actccagcac ctgttcctgt gtcaaaggtc ccagcaaata taacacgtca aaacagcagc     1980

tccagtgaca gtggtggcag tatcgtgcga gacagccaga gacacaaaca acttccggtg     2040

gaccgaagga aatctcagat ggaggaagtg caagatgaac tcatccacag actgaccatt     2100

ggtcggagtg ccgctcagaa gaaattccat gtgccacggc agaacgtgcc agttatcaat     2160

atcacttacg actccacacc agaggatgtg aagacgtggt tacagtcaaa gggattcaac     2220

cctgtgactg tcaatagtct tggagtatta aatggtgcac aacttttctc tctcaataag     2280

gatgaactga ggacagtctg ccctgaaggg gcgagagtct atagccaaat cactgtacaa     2340

aaagctgcat tggaggatag cagtggcagc tccgagttac aagaaattat gagaagacga     2400

caggaaaaaa tcagtgctgc cgctagtgat tcaggagtgg aatcttttga tgaaggaagc     2460

agtcactaa                                                             2469


<210>  80
<211>  822
<212>  PRT
<213>  Homo sapiens

<400>  80

Met Asn Gly His Ile Ser Asn His Pro Ser Ser Phe Gly Met Tyr Pro 
1               5                   10                  15      


Ser Gln Met Asn Gly Tyr Gly Ser Ser Pro Thr Phe Ser Gln Thr Asp 
            20                  25                  30          


Arg Glu His Gly Ser Lys Thr Ser Ala Lys Ala Leu Tyr Glu Gln Arg 
        35                  40                  45              


Lys Asn Tyr Ala Arg Asp Ser Val Ser Ser Val Ser Asp Ile Ser Gln 
    50                  55                  60                  


Tyr Arg Val Glu His Leu Thr Thr Phe Val Leu Asp Arg Lys Asp Ala 
65                  70                  75                  80  


Met Ile Thr Val Asp Asp Gly Ile Arg Lys Leu Lys Leu Leu Asp Ala 
                85                  90                  95      


Lys Gly Lys Val Trp Thr Gln Asp Met Ile Leu Gln Val Asp Asp Arg 
            100                 105                 110         


Ala Val Ser Leu Ile Asp Leu Glu Ser Lys Asn Glu Leu Glu Asn Phe 
        115                 120                 125             


Pro Leu Asn Thr Ile Gln His Cys Gln Ala Val Met His Ser Cys Ser 
    130                 135                 140                 


Tyr Asp Ser Val Leu Ala Leu Val Cys Lys Glu Pro Thr Gln Asn Lys 
145                 150                 155                 160 


Pro Asp Leu His Leu Phe Gln Cys Asp Glu Val Lys Ala Asn Leu Ile 
                165                 170                 175     


Ser Glu Asp Ile Glu Ser Ala Ile Ser Asp Ser Lys Gly Gly Lys Gln 
            180                 185                 190         


Lys Arg Arg Pro Asp Ala Leu Arg Met Ile Ser Asn Ala Asp Pro Ser 
        195                 200                 205             


Ile Pro Pro Pro Pro Arg Ala Pro Ala Pro Ala Pro Pro Gly Thr Val 
    210                 215                 220                 


Thr Gln Val Asp Val Arg Ser Arg Val Ala Ala Trp Ser Ala Trp Ala 
225                 230                 235                 240 


Ala Asp Gln Gly Asp Phe Glu Lys Pro Arg Gln Tyr His Glu Gln Glu 
                245                 250                 255     


Glu Thr Pro Glu Met Met Ala Ala Arg Ile Asp Arg Asp Val Gln Ile 
            260                 265                 270         


Leu Asn His Ile Leu Asp Asp Ile Glu Phe Phe Ile Thr Lys Leu Gln 
        275                 280                 285             


Lys Ala Ala Glu Ala Phe Ser Glu Leu Ser Lys Arg Lys Lys Asn Lys 
    290                 295                 300                 


Lys Gly Lys Arg Lys Gly Pro Gly Glu Gly Val Leu Thr Leu Arg Ala 
305                 310                 315                 320 


Lys Pro Pro Pro Pro Asp Glu Phe Leu Asp Cys Phe Gln Lys Phe Lys 
                325                 330                 335     


His Gly Phe Asn Leu Leu Ala Lys Leu Lys Ser His Ile Gln Asn Pro 
            340                 345                 350         


Ser Ala Ala Asp Leu Val His Phe Leu Phe Thr Pro Leu Asn Met Val 
        355                 360                 365             


Val Gln Ala Thr Gly Gly Pro Glu Leu Ala Ser Ser Val Leu Ser Pro 
    370                 375                 380                 


Leu Leu Asn Lys Asp Thr Ile Asp Phe Leu Asn Tyr Thr Val Asn Gly 
385                 390                 395                 400 


Asp Glu Arg Gln Leu Trp Met Ser Leu Gly Gly Thr Trp Met Lys Ala 
                405                 410                 415     


Arg Ala Glu Trp Pro Lys Glu Gln Phe Ile Pro Pro Tyr Val Pro Arg 
            420                 425                 430         


Phe Arg Asn Gly Trp Glu Pro Pro Met Leu Asn Phe Met Gly Ala Thr 
        435                 440                 445             


Met Glu Gln Asp Leu Tyr Gln Leu Ala Glu Ser Val Ala Asn Val Ala 
    450                 455                 460                 


Glu His Gln Arg Lys Gln Glu Ile Lys Arg Leu Ser Thr Glu His Ser 
465                 470                 475                 480 


Ser Val Ser Glu Tyr His Pro Ala Asp Gly Tyr Ala Phe Ser Ser Asn 
                485                 490                 495     


Ile Tyr Thr Arg Gly Ser His Leu Asp Gln Gly Glu Ala Ala Val Ala 
            500                 505                 510         


Phe Lys Pro Thr Ser Asn Arg His Ile Asp Arg Asn Tyr Glu Pro Leu 
        515                 520                 525             


Lys Thr Gln Pro Lys Lys Tyr Ala Lys Ser Lys Tyr Asp Phe Val Ala 
    530                 535                 540                 


Arg Asn Asn Ser Glu Leu Ser Val Leu Lys Asp Asp Ile Leu Glu Ile 
545                 550                 555                 560 


Leu Asp Asp Arg Lys Gln Trp Trp Lys Val Arg Asn Ala Ser Gly Asp 
                565                 570                 575     


Ser Gly Phe Val Pro Asn Asn Ile Leu Asp Ile Val Arg Pro Pro Glu 
            580                 585                 590         


Ser Gly Leu Gly Arg Ala Asp Pro Pro Tyr Thr His Thr Ile Gln Lys 
        595                 600                 605             


Gln Arg Met Glu Tyr Gly Pro Arg Pro Ala Asp Thr Pro Pro Ala Pro 
    610                 615                 620                 


Ser Pro Pro Pro Thr Pro Ala Pro Val Pro Val Pro Leu Pro Pro Ser 
625                 630                 635                 640 


Thr Pro Ala Pro Val Pro Val Ser Lys Val Pro Ala Asn Ile Thr Arg 
                645                 650                 655     


Gln Asn Ser Ser Ser Ser Asp Ser Gly Gly Ser Ile Val Arg Asp Ser 
            660                 665                 670         


Gln Arg His Lys Gln Leu Pro Val Asp Arg Arg Lys Ser Gln Met Glu 
        675                 680                 685             


Glu Val Gln Asp Glu Leu Ile His Arg Leu Thr Ile Gly Arg Ser Ala 
    690                 695                 700                 


Ala Gln Lys Lys Phe His Val Pro Arg Gln Asn Val Pro Val Ile Asn 
705                 710                 715                 720 


Ile Thr Tyr Asp Ser Thr Pro Glu Asp Val Lys Thr Trp Leu Gln Ser 
                725                 730                 735     


Lys Gly Phe Asn Pro Val Thr Val Asn Ser Leu Gly Val Leu Asn Gly 
            740                 745                 750         


Ala Gln Leu Phe Ser Leu Asn Lys Asp Glu Leu Arg Thr Val Cys Pro 
        755                 760                 765             


Glu Gly Ala Arg Val Tyr Ser Gln Ile Thr Val Gln Lys Ala Ala Leu 
    770                 775                 780                 


Glu Asp Ser Ser Gly Ser Ser Glu Leu Gln Glu Ile Met Arg Arg Arg 
785                 790                 795                 800 


Gln Glu Lys Ile Ser Ala Ala Ala Ser Asp Ser Gly Val Glu Ser Phe 
                805                 810                 815     


Asp Glu Gly Ser Ser His 
            820         


<210>  81
<211>  894
<212>  DNA
<213>  Homo sapiens

<400>  81
atggaccctg ggaaggacaa agagggggtg ccccagccct cagggccgcc agcaaggaag       60

aaatttgtga tacccctcga cgaggatgag gtccctcctg gagtggccaa gcccttattc      120

cgatctacac agagccttcc cactgtggac acctcggccc aggcggcccc tcagacctac      180

gccgaatatg ccatctcaca gcctctggaa ggggctgggg ccacgtgccc cacagggtca      240

gagcccctgg caggagagac gcccaaccag gccctgaaac ccggggcaaa atccaacagc      300

atcattgtga gccctcggca gaggggcaat cccgtactga agttcgtgcg caatgtgccc      360

tgggaatttg gcgacgtaat tcccgactat gtgctgggcc agagcacctg tgccctgttc      420

ctcagcctcc gctaccacaa cctgcaccca gactacatcc atgggcggct gcagagcctg      480

gggaagaact tcgccttgcg ggtcctgctt gtccaggtgg atgtgaaaga tccccagcag      540

gccctcaagg agctggctaa gatgtgtatc ctggccgact gcacattgat cctcgcctgg      600

agccccgagg aagctgggcg gtacctggag acctacaagg cctatgagca gaaaccagcg      660

gacctcctga tggagaagct agagcaggac ttcgtctccc gggtgactga atgtctgacc      720

accgtgaagt cagtcaacaa aacggacagt cagaccctcc tgaccacatt tggatctctg      780

gaacagctca tcgccgcatc aagagaagat ctggccttat gcccaggcct gggccctcag      840

aaagcccgga ggctgtttga tgtcctgcac gagcccttct tgaaagtacc ctga            894


<210>  82
<211>  297
<212>  PRT
<213>  Homo sapiens

<400>  82

Met Asp Pro Gly Lys Asp Lys Glu Gly Val Pro Gln Pro Ser Gly Pro 
1               5                   10                  15      


Pro Ala Arg Lys Lys Phe Val Ile Pro Leu Asp Glu Asp Glu Val Pro 
            20                  25                  30          


Pro Gly Val Ala Lys Pro Leu Phe Arg Ser Thr Gln Ser Leu Pro Thr 
        35                  40                  45              


Val Asp Thr Ser Ala Gln Ala Ala Pro Gln Thr Tyr Ala Glu Tyr Ala 
    50                  55                  60                  


Ile Ser Gln Pro Leu Glu Gly Ala Gly Ala Thr Cys Pro Thr Gly Ser 
65                  70                  75                  80  


Glu Pro Leu Ala Gly Glu Thr Pro Asn Gln Ala Leu Lys Pro Gly Ala 
                85                  90                  95      


Lys Ser Asn Ser Ile Ile Val Ser Pro Arg Gln Arg Gly Asn Pro Val 
            100                 105                 110         


Leu Lys Phe Val Arg Asn Val Pro Trp Glu Phe Gly Asp Val Ile Pro 
        115                 120                 125             


Asp Tyr Val Leu Gly Gln Ser Thr Cys Ala Leu Phe Leu Ser Leu Arg 
    130                 135                 140                 


Tyr His Asn Leu His Pro Asp Tyr Ile His Gly Arg Leu Gln Ser Leu 
145                 150                 155                 160 


Gly Lys Asn Phe Ala Leu Arg Val Leu Leu Val Gln Val Asp Val Lys 
                165                 170                 175     


Asp Pro Gln Gln Ala Leu Lys Glu Leu Ala Lys Met Cys Ile Leu Ala 
            180                 185                 190         


Asp Cys Thr Leu Ile Leu Ala Trp Ser Pro Glu Glu Ala Gly Arg Tyr 
        195                 200                 205             


Leu Glu Thr Tyr Lys Ala Tyr Glu Gln Lys Pro Ala Asp Leu Leu Met 
    210                 215                 220                 


Glu Lys Leu Glu Gln Asp Phe Val Ser Arg Val Thr Glu Cys Leu Thr 
225                 230                 235                 240 


Thr Val Lys Ser Val Asn Lys Thr Asp Ser Gln Thr Leu Leu Thr Thr 
                245                 250                 255     


Phe Gly Ser Leu Glu Gln Leu Ile Ala Ala Ser Arg Glu Asp Leu Ala 
            260                 265                 270         


Leu Cys Pro Gly Leu Gly Pro Gln Lys Ala Arg Arg Leu Phe Asp Val 
        275                 280                 285             


Leu His Glu Pro Phe Leu Lys Val Pro 
    290                 295         


<210>  83
<211>  2241
<212>  DNA
<213>  Homo sapiens

<400>  83
atgggccaga ctgggaagaa atctgagaag ggaccagttt gttggcggaa gcgtgtaaaa       60

tcagagtaca tgcgactgag acagctcaag aggttcagac gagctgatga agtaaagagt      120

atgtttagtt ccaatcgtca gaaaattttg gaaagaacgg aaatcttaaa ccaagaatgg      180

aaacagcgaa ggatacagcc tgtgcacatc ctgacttctg tgagctcatt gcgcgggact      240

agggagtgtt cggtgaccag tgacttggat tttccaacac aagtcatccc attaaagact      300

ctgaatgcag ttgcttcagt acccataatg tattcttggt ctcccctaca gcagaatttt      360

atggtggaag atgaaactgt tttacataac attccttata tgggagatga agttttagat      420

caggatggta ctttcattga agaactaata aaaaattatg atgggaaagt acacggggat      480

agagaatgtg ggtttataaa tgatgaaatt tttgtggagt tggtgaatgc ccttggtcaa      540

tataatgatg atgacgatga tgatgatgga gacgatcctg aagaaagaga agaaaagcag      600

aaagatctgg aggatcaccg agatgataaa gaaagccgcc cacctcggaa atttccttct      660

gataaaattt ttgaagccat ttcctcaatg tttccagata agggcacagc agaagaacta      720

aaggaaaaat ataaagaact caccgaacag cagctcccag gcgcacttcc tcctgaatgt      780

acccccaaca tagatggacc aaatgctaaa tctgttcaga gagagcaaag cttacactcc      840

tttcatacgc ttttctgtag gcgatgtttt aaatatgact gcttcctaca tccttttcat      900

gcaacaccca acacttataa gcggaagaac acagaaacag ctctagacaa caaaccttgt      960

ggaccacagt gttaccagca tttggaggga gcaaaggagt ttgctgctgc tctcaccgct     1020

gagcggataa agaccccacc aaaacgtcca ggaggccgca gaagaggacg gcttcccaat     1080

aacagtagca ggcccagcac ccccaccatt aatgtgctgg aatcaaagga tacagacagt     1140

gatagggaag cagggactga aacgggggga gagaacaatg ataaagaaga agaagagaag     1200

aaagatgaaa cttcgagctc ctctgaagca aattctcggt gtcaaacacc aataaagatg     1260

aagccaaata ttgaacctcc tgagaatgtg gagtggagtg gtgctgaagc ctcaatgttt     1320

agagtcctca ttggcactta ctatgacaat ttctgtgcca ttgctaggtt aattgggacc     1380

aaaacatgta gacaggtgta tgagtttaga gtcaaagaat ctagcatcat agctccagct     1440

cccgctgagg atgtggatac tcctccaagg aaaaagaaga ggaaacaccg gttgtgggct     1500

gcacactgca gaaagataca gctgaaaaag gacggctcct ctaaccatgt ttacaactat     1560

caaccctgtg atcatccacg gcagccttgt gacagttcgt gcccttgtgt gatagcacaa     1620

aatttttgtg aaaagttttg tcaatgtagt tcagagtgtc aaaaccgctt tccgggatgc     1680

cgctgcaaag cacagtgcaa caccaagcag tgcccgtgct acctggctgt ccgagagtgt     1740

gaccctgacc tctgtcttac ttgtggagcc gctgaccatt gggacagtaa aaatgtgtcc     1800

tgcaagaact gcagtattca gcggggctcc aaaaagcatc tattgctggc accatctgac     1860

gtggcaggct gggggatttt tatcaaagat cctgtgcaga aaaatgaatt catctcagaa     1920

tactgtggag agattatttc tcaagatgaa gctgacagaa gagggaaagt gtatgataaa     1980

tacatgtgca gctttctgtt caacttgaac aatgattttg tggtggatgc aacccgcaag     2040

ggtaacaaaa ttcgttttgc aaatcattcg gtaaatccaa actgctatgc aaaagttatg     2100

atggttaacg gtgatcacag gataggtatt tttgccaaga gagccatcca gactggcgaa     2160

gagctgtttt ttgattacag atacagccag gctgatgccc tgaagtatgt cggcatcgaa     2220

agagaaatgg aaatcccttg a                                               2241


<210>  84
<211>  746
<212>  PRT
<213>  Homo sapiens

<400>  84

Met Gly Gln Thr Gly Lys Lys Ser Glu Lys Gly Pro Val Cys Trp Arg 
1               5                   10                  15      


Lys Arg Val Lys Ser Glu Tyr Met Arg Leu Arg Gln Leu Lys Arg Phe 
            20                  25                  30          


Arg Arg Ala Asp Glu Val Lys Ser Met Phe Ser Ser Asn Arg Gln Lys 
        35                  40                  45              


Ile Leu Glu Arg Thr Glu Ile Leu Asn Gln Glu Trp Lys Gln Arg Arg 
    50                  55                  60                  


Ile Gln Pro Val His Ile Leu Thr Ser Val Ser Ser Leu Arg Gly Thr 
65                  70                  75                  80  


Arg Glu Cys Ser Val Thr Ser Asp Leu Asp Phe Pro Thr Gln Val Ile 
                85                  90                  95      


Pro Leu Lys Thr Leu Asn Ala Val Ala Ser Val Pro Ile Met Tyr Ser 
            100                 105                 110         


Trp Ser Pro Leu Gln Gln Asn Phe Met Val Glu Asp Glu Thr Val Leu 
        115                 120                 125             


His Asn Ile Pro Tyr Met Gly Asp Glu Val Leu Asp Gln Asp Gly Thr 
    130                 135                 140                 


Phe Ile Glu Glu Leu Ile Lys Asn Tyr Asp Gly Lys Val His Gly Asp 
145                 150                 155                 160 


Arg Glu Cys Gly Phe Ile Asn Asp Glu Ile Phe Val Glu Leu Val Asn 
                165                 170                 175     


Ala Leu Gly Gln Tyr Asn Asp Asp Asp Asp Asp Asp Asp Gly Asp Asp 
            180                 185                 190         


Pro Glu Glu Arg Glu Glu Lys Gln Lys Asp Leu Glu Asp His Arg Asp 
        195                 200                 205             


Asp Lys Glu Ser Arg Pro Pro Arg Lys Phe Pro Ser Asp Lys Ile Phe 
    210                 215                 220                 


Glu Ala Ile Ser Ser Met Phe Pro Asp Lys Gly Thr Ala Glu Glu Leu 
225                 230                 235                 240 


Lys Glu Lys Tyr Lys Glu Leu Thr Glu Gln Gln Leu Pro Gly Ala Leu 
                245                 250                 255     


Pro Pro Glu Cys Thr Pro Asn Ile Asp Gly Pro Asn Ala Lys Ser Val 
            260                 265                 270         


Gln Arg Glu Gln Ser Leu His Ser Phe His Thr Leu Phe Cys Arg Arg 
        275                 280                 285             


Cys Phe Lys Tyr Asp Cys Phe Leu His Pro Phe His Ala Thr Pro Asn 
    290                 295                 300                 


Thr Tyr Lys Arg Lys Asn Thr Glu Thr Ala Leu Asp Asn Lys Pro Cys 
305                 310                 315                 320 


Gly Pro Gln Cys Tyr Gln His Leu Glu Gly Ala Lys Glu Phe Ala Ala 
                325                 330                 335     


Ala Leu Thr Ala Glu Arg Ile Lys Thr Pro Pro Lys Arg Pro Gly Gly 
            340                 345                 350         


Arg Arg Arg Gly Arg Leu Pro Asn Asn Ser Ser Arg Pro Ser Thr Pro 
        355                 360                 365             


Thr Ile Asn Val Leu Glu Ser Lys Asp Thr Asp Ser Asp Arg Glu Ala 
    370                 375                 380                 


Gly Thr Glu Thr Gly Gly Glu Asn Asn Asp Lys Glu Glu Glu Glu Lys 
385                 390                 395                 400 


Lys Asp Glu Thr Ser Ser Ser Ser Glu Ala Asn Ser Arg Cys Gln Thr 
                405                 410                 415     


Pro Ile Lys Met Lys Pro Asn Ile Glu Pro Pro Glu Asn Val Glu Trp 
            420                 425                 430         


Ser Gly Ala Glu Ala Ser Met Phe Arg Val Leu Ile Gly Thr Tyr Tyr 
        435                 440                 445             


Asp Asn Phe Cys Ala Ile Ala Arg Leu Ile Gly Thr Lys Thr Cys Arg 
    450                 455                 460                 


Gln Val Tyr Glu Phe Arg Val Lys Glu Ser Ser Ile Ile Ala Pro Ala 
465                 470                 475                 480 


Pro Ala Glu Asp Val Asp Thr Pro Pro Arg Lys Lys Lys Arg Lys His 
                485                 490                 495     


Arg Leu Trp Ala Ala His Cys Arg Lys Ile Gln Leu Lys Lys Asp Gly 
            500                 505                 510         


Ser Ser Asn His Val Tyr Asn Tyr Gln Pro Cys Asp His Pro Arg Gln 
        515                 520                 525             


Pro Cys Asp Ser Ser Cys Pro Cys Val Ile Ala Gln Asn Phe Cys Glu 
    530                 535                 540                 


Lys Phe Cys Gln Cys Ser Ser Glu Cys Gln Asn Arg Phe Pro Gly Cys 
545                 550                 555                 560 


Arg Cys Lys Ala Gln Cys Asn Thr Lys Gln Cys Pro Cys Tyr Leu Ala 
                565                 570                 575     


Val Arg Glu Cys Asp Pro Asp Leu Cys Leu Thr Cys Gly Ala Ala Asp 
            580                 585                 590         


His Trp Asp Ser Lys Asn Val Ser Cys Lys Asn Cys Ser Ile Gln Arg 
        595                 600                 605             


Gly Ser Lys Lys His Leu Leu Leu Ala Pro Ser Asp Val Ala Gly Trp 
    610                 615                 620                 


Gly Ile Phe Ile Lys Asp Pro Val Gln Lys Asn Glu Phe Ile Ser Glu 
625                 630                 635                 640 


Tyr Cys Gly Glu Ile Ile Ser Gln Asp Glu Ala Asp Arg Arg Gly Lys 
                645                 650                 655     


Val Tyr Asp Lys Tyr Met Cys Ser Phe Leu Phe Asn Leu Asn Asn Asp 
            660                 665                 670         


Phe Val Val Asp Ala Thr Arg Lys Gly Asn Lys Ile Arg Phe Ala Asn 
        675                 680                 685             


His Ser Val Asn Pro Asn Cys Tyr Ala Lys Val Met Met Val Asn Gly 
    690                 695                 700                 


Asp His Arg Ile Gly Ile Phe Ala Lys Arg Ala Ile Gln Thr Gly Glu 
705                 710                 715                 720 


Glu Leu Phe Phe Asp Tyr Arg Tyr Ser Gln Ala Asp Ala Leu Lys Tyr 
                725                 730                 735     


Val Gly Ile Glu Arg Glu Met Glu Ile Pro 
            740                 745     


<210>  85
<211>  7944
<212>  DNA
<213>  Homo sapiens

<400>  85
atgagtagct cccactctcg ggcgggccag agcgcagcag gcgcggctcc gggcggcggc       60

gtcgacacgc gggacgccga gatgccggcc accgagaagg acctggcgga ggacgcgccg      120

tggaagaaga tccagcagaa cactttcacg cgctggtgca acgagcacct gaagtgcgtg      180

agcaagcgca tcgccaacct gcagacggac ctgagcgacg ggctgcggct tatcgcgctg      240

ttggaggtgc tcagccagaa gaagatgcac cgcaagcaca accagcggcc cactttccgc      300

caaatgcagc ttgagaacgt gtcggtggcg ctcgagttcc tggaccgcga gagcatcaaa      360

ctggtgtcca tcgacagcaa ggccatcgtg gacgggaacc tgaagctgat cctgggcctc      420

atctggaccc tgatcctgca ctactccatc tccatgccca tgtgggacga ggaggaggat      480

gaggaggcca agaagcagac ccccaagcag aggctcctgg gctggatcca gaacaagctg      540

ccgcagctgc ccatcaccaa cttcagccgg gactggcaga gcggccgggc cctgggcgcc      600

ctggtggaca gctgtgcccc gggcctgtgt cctgactggg actcttggga cgccagcaag      660

cccgttacca atgcgcgaga ggccatgcag caggcggatg actggctggg catcccccag      720

gtgatcaccc ccgaggagat tgtggacccc aacgtggacg agcactctgt catgacctac      780

ctgtcccagt tccccaaggc caagctgaag ccaggggctc ccttgcgccc caaactgaac      840

ccgaagaaag cccgtgccta cgggccaggc atcgagccca caggcaacat ggtgaagaag      900

cgggcagagt tcactgtgga gaccagaagt gctggccagg gagaggtgct ggtgtacgtg      960

gaggacccgg ccggacacca ggaggaggca aaagtgaccg ccaataacga caagaaccgc     1020

accttctccg tctggtacgt ccccgaggtg acggggactc ataaggttac tgtgctcttt     1080

gctggccagc acatcgccaa gagccccttc gaggtgtacg tggataagtc acagggtgac     1140

gccagcaaag tgacagccca aggtcccggc ctggagccca gtggcaacat cgccaacaag     1200

accacctact ttgagatctt tacggcagga gctggcacgg gcgaggtcga ggttgtgatc     1260

caggacccca tgggacagaa gggcacggta gagcctcagc tggaggcccg gggcgacagc     1320

acataccgct gcagctacca gcccaccatg gagggcgtcc acaccgtgca cgtcacgttt     1380

gccggcgtgc ccatccctcg cagcccctac actgtcactg ttggccaagc ctgtaacccg     1440

agtgcctgcc gggcggttgg ccggggcctc cagcccaagg gtgtgcgggt gaaggagaca     1500

gctgacttca aggtgtacac aaagggcgct ggcagtgggg agctgaaggt caccgtgaag     1560

ggccccaagg gagaggagcg cgtgaagcag aaggacctgg gggatggcgt gtatggcttc     1620

gagtattacc ccatggtccc tggaacctat atcgtcacca tcacgtgggg tggtcagaac     1680

atcgggcgca gtcccttcga agtgaaggtg ggcaccgagt gtggcaatca gaaggtacgg     1740

gcctggggcc ctgggctgga gggcggcgtc gttggcaagt cagcagactt tgtggtggag     1800

gctatcgggg acgacgtggg cacgctgggc ttctcggtgg aagggccatc gcaggctaag     1860

atcgaatgtg acgacaaggg cgacggctcc tgtgatgtgc gctactggcc gcaggaggct     1920

ggcgagtatg ccgttcacgt gctgtgcaac agcgaagaca tccgcctcag ccccttcatg     1980

gctgacatcc gtgacgcgcc ccaggacttc cacccagaca gggtgaaggc acgtgggcct     2040

ggattggaga agacaggtgt ggccgtcaac aagccagcag agttcacagt ggatgccaag     2100

cacggtggca aggccccact tcgggtccaa gtccaggaca atgaaggctg ccctgtggag     2160

gcgttggtca aggacaacgg caatggcact tacagctgct cctacgtgcc caggaagccg     2220

gtgaagcaca cagccatggt gtcctgggga ggcgtcagca tccccaacag ccccttcagg     2280

gtgaatgtgg gagctggcag ccaccccaac aaggtcaaag tatacggccc cggagtagcc     2340

aagacagggc tcaaggccca cgagcccacc tacttcactg tggactgcgc cgaggctggc     2400

cagggggacg tcagcatcgg catcaagtgt gcccctggag tggtaggccc cgccgaagct     2460

gacatcgact tcgacatcat ccgcaatgac aatgacacct tcacggtcaa gtacacgccc     2520

cggggggctg gcagctacac cattatggtc ctctttgctg accaggccac gcccaccagc     2580

cccatccgag tcaaggtgga gccctctcat gacgccagta aggtgaaggc cgagggccct     2640

ggcctcagtc gcactggtgt cgagcttggc aagcccaccc acttcacagt aaatgccaaa     2700

gctgctggca aaggcaagct ggacgtccag ttctcaggac tcaccaaggg ggatgcagtg     2760

cgagatgtgg acatcatcga ccaccatgac aacacctaca cagtcaagta cacgcctgtc     2820

cagcagggtc cagtaggcgt caatgtcact tatggagggg atcccatccc taagagccct     2880

ttctcagtgg cagtatctcc aagcctggac ctcagcaaga tcaaggtgtc tggcctggga     2940

gagaaggtgg acgttggcaa agaccaggag ttcacagtca aatcaaaggg tgctggtggt     3000

caaggcaaag tggcatccaa gattgtgggc ccctcgggtg cagcggtgcc ctgcaaggtg     3060

gagccaggcc tgggggctga caacagtgtg gtgcgcttcc tgccccgtga ggaagggccc     3120

tatgaggtgg aggtgaccta tgacggcgtg cccgtgcctg gcagcccctt tcctctggaa     3180

gctgtggccc ccaccaagcc tagcaaggtg aaggcgtttg ggccggggct gcagggaggc     3240

agtgcgggct cccccgcccg cttcaccatc gacaccaagg gcgccggcac aggtggcctg     3300

ggcctgacgg tggagggccc ctgtgaggcg cagctcgagt gcttggacaa tggggatggc     3360

acatgttccg tgtcctacgt gcccaccgag cccggggact acaacatcaa catcctcttc     3420

gctgacaccc acatccctgg ctccccattc aaggcccacg tggttccctg ctttgacgca     3480

tccaaagtca agtgctcagg ccccgggctg gagcgggcca ccgctgggga ggtgggccaa     3540

ttccaagtgg actgctcgag cgcgggcagc gcggagctga ccattgagat ctgctcggag     3600

gcggggcttc cggccgaggt gtacatccag gaccacggtg atggcacgca caccattacc     3660

tacattcccc tctgccccgg ggcctacacc gtcaccatca agtacggcgg ccagcccgtg     3720

cccaacttcc ccagcaagct gcaggtggaa cctgcggtgg acacttccgg tgtccagtgc     3780

tatgggcctg gtattgaggg ccagggtgtc ttccgtgagg ccaccactga gttcagtgtg     3840

gacgcccggg ctctgacaca gaccggaggg ccgcacgtca aggcccgtgt ggccaacccc     3900

tcaggcaacc tgacggagac ctacgttcag gaccgtggcg atggcatgta caaagtggag     3960

tacacgcctt acgaggaggg actgcactcc gtggacgtga cctatgacgg cagtcccgtg     4020

cccagcagcc ccttccaggt gcccgtgacc gagggctgcg acccctcccg ggtgcgtgtc     4080

cacgggccag gcatccaaag tggcaccacc aacaagccca acaagttcac tgtggagacc     4140

aggggagctg gcacgggcgg cctgggcctg gctgtagagg gcccctccga ggccaagatg     4200

tcctgcatgg ataacaagga cggcagctgc tcggtcgagt acatccctta tgaggctggc     4260

acctacagcc tcaacgtcac ctatggtggc catcaagtgc caggcagtcc tttcaaggtc     4320

cctgtgcatg atgtgacaga tgcgtccaag gtcaagtgct ctgggcccgg cctgagccca     4380

ggcatggttc gtgccaacct ccctcagtcc ttccaggtgg acacaagcaa ggctggtgtg     4440

gccccattgc aggtcaaagt gcaagggccc aaaggcctgg tggagccagt ggacgtggta     4500

gacaacgctg atggcaccca gaccgtcaat tatgtgccca gccgagaagg gccctacagc     4560

atctcagtac tgtatggaga tgaagaggta ccccggagcc ccttcaaggt caaggtgctg     4620

cctactcatg atgccagcaa ggtgaaggcc agtggccccg ggctcaacac cactggcgtg     4680

cctgccagcc tgcccgtgga gttcaccatc gatgcaaagg acgccgggga gggcctgctg     4740

gctgtccaga tcacggatcc cgaaggcaag ccgaagaaga cacacatcca agacaaccat     4800

gacggcacgt atacagtggc ctacgtgcca gacgtgacag gtcgctacac catcctcatc     4860

aagtacggtg gtgacgagat ccccttctcc ccgtaccgcg tgcgtgccgt gcccaccggg     4920

gacgccagca agtgcactgt cacagtgtca atcggaggtc acgggctagg tgctggcatc     4980

ggccccacca ttcagattgg ggaggagacg gtgatcactg tggacactaa ggcggcaggc     5040

aaaggcaaag tgacgtgcac cgtgtgcacg cctgatggct cagaggtgga tgtggacgtg     5100

gtggagaatg aggacggcac tttcgacatc ttctacacgg ccccccagcc gggcaaatac     5160

gtcatctgtg tgcgctttgg tggcgagcac gtgcccaaca gccccttcca agtgacggct     5220

ctggctgggg accagccctc ggtgcagccc cctctacggt ctcagcagct ggccccacag     5280

tacacctacg cccagggcgg ccagcagact tgggccccgg agaggcccct ggtgggtgtc     5340

aatgggctgg atgtgaccag cctgaggccc tttgaccttg tcatcccctt caccatcaag     5400

aagggcgaga tcacagggga ggttcggatg ccctcaggca aggtggcgca gcccaccatc     5460

actgacaaca aagacggcac cgtgaccgtg cggtatgcac ccagcgaggc tggcctgcac     5520

gagatggaca tccgctatga caacatgcac atcccaggaa gccccttgca gttctatgtg     5580

gattacgtca actgtggcca tgtcactgcc tatgggcctg gcctcaccca tggagtagtg     5640

aacaagcctg ccaccttcac cgtcaacacc aaggatgcag gagagggggg cctgtctctg     5700

gccattgagg gcccgtccaa agcagaaatc agctgcactg acaaccagga tgggacatgc     5760

agcgtgtcct acctgcctgt gctgccgggg gactacagca ttctagtcaa gtacaatgaa     5820

cagcacgtcc caggcagccc cttcactgct cgggtcacag gtgacgactc catgcgtatg     5880

tcccacctaa aggtcggctc tgctgccgac atccccatca acatctcaga gacggatctc     5940

agcctgctga cggccactgt ggtcccgccc tcgggccggg aggagccctg tttgctgaag     6000

cggctgcgta atggccacgt ggggatttca ttcgtgccca aggagacggg ggagcacctg     6060

gtgcatgtga agaaaaatgg ccagcacgtg gccagcagcc ccatcccggt ggtgatcagc     6120

cagtcggaaa ttggggatgc cagtcgtgtt cgggtctctg gtcagggcct tcacgaaggc     6180

cacacctttg agcctgcaga gtttatcatt gatacccgcg atgcaggcta tggtgggctc     6240

agcctgtcca ttgagggccc cagcaaggtg gacatcaaca cagaggacct ggaggacggg     6300

acgtgcaggg tcacctactg ccccacagag ccaggcaact acatcatcaa catcaagttt     6360

gccgaccagc acgtgcctgg cagccccttc tctgtgaagg tgacaggcga gggccgggtg     6420

aaagagagca tcacccgcag gcgtcgggct ccttcagtgg ccaacgttgg tagtcattgt     6480

gacctcagcc tgaaaatccc tgaaattagc atccaggata tgacagccca ggtgaccagc     6540

ccatcgggca agacccatga ggccgagatc gtggaagggg agaaccacac ctactgcatc     6600

cgctttgttc ccgctgagat gggcacacac acagtcagcg tcaagtacaa gggccagcac     6660

gtgcctggga gccccttcca gttcaccgtg gggcccctag gggaaggggg agcccacaag     6720

gtccgagctg ggggccctgg cctggagaga gctgaagctg gagtgccagc cgaattcagt     6780

atctggaccc gggaagctgg tgctggaggc ctggccattg ctgtcgaggg ccccagcaag     6840

gctgagatct cttttgagga ccgcaaggac ggctcctgtg gtgtggctta tgtggtccag     6900

gagccaggtg actacgaagt ctcagtcaag ttcaacgagg aacacattcc cgacagcccc     6960

ttcgtggtgc ctgtggcttc tccgtctggc gacgcccgcc gcctcactgt ttctagcctt     7020

caggagtcag ggctaaaggt caaccagcca gcctcttttg cagtcagcct gaacggggcc     7080

aagggggcga tcgatgccaa ggtgcacagc ccctcaggag ccctggagga gtgctatgtc     7140

acagaaattg accaagataa gtatgctgtg cgcttcatcc ctcgggagaa tggcgtttac     7200

ctgattgacg tcaagttcaa cggtacccac atccctggaa gccccttcaa gatccgagtt     7260

ggggagcctg ggcatggagg ggacccaggc ttggtgtctg cttacggagc aggtctggaa     7320

ggcggtgtca cagggaaccc agctgagttc gtcgtgaaca cgagcaatgc gggagctggt     7380

gccctgtcgg tgaccattga cggcccctcc aaggtgaaga tggattgcca ggagtgccct     7440

gagggctacc gcgtcaccta tacccccatg gcacctggca gctacctcat ctccatcaag     7500

tacggcggcc cctaccacat tgggggcagc cccttcaagg ccaaagtcac aggcccccgt     7560

ctcgtcagca accacagcct ccacgagaca tcatcagtgt ttgtagactc tctgaccaag     7620

gccacctgtg ccccccagca tggggccccg ggtcctgggc ctgctgacgc cagcaaggtg     7680

gtggccaagg gcctggggct gagcaaggcc tacgtaggcc agaagagcag cttcacagta     7740

gactgcagca aagcaggcaa caacatgctg ctggtggggg ttcatggccc aaggaccccc     7800

tgcgaggaga tcctggtgaa gcacgtgggc agccggctct acagcgtgtc ctacctgctc     7860

aaggacaagg gggagtacac actggtggtc aaatgggggc acgagcacat cccaggcagc     7920

ccctaccgcg ttgtggtgcc ctga                                            7944


<210>  86
<211>  2647
<212>  PRT
<213>  Homo sapiens

<400>  86

Met Ser Ser Ser His Ser Arg Ala Gly Gln Ser Ala Ala Gly Ala Ala 
1               5                   10                  15      


Pro Gly Gly Gly Val Asp Thr Arg Asp Ala Glu Met Pro Ala Thr Glu 
            20                  25                  30          


Lys Asp Leu Ala Glu Asp Ala Pro Trp Lys Lys Ile Gln Gln Asn Thr 
        35                  40                  45              


Phe Thr Arg Trp Cys Asn Glu His Leu Lys Cys Val Ser Lys Arg Ile 
    50                  55                  60                  


Ala Asn Leu Gln Thr Asp Leu Ser Asp Gly Leu Arg Leu Ile Ala Leu 
65                  70                  75                  80  


Leu Glu Val Leu Ser Gln Lys Lys Met His Arg Lys His Asn Gln Arg 
                85                  90                  95      


Pro Thr Phe Arg Gln Met Gln Leu Glu Asn Val Ser Val Ala Leu Glu 
            100                 105                 110         


Phe Leu Asp Arg Glu Ser Ile Lys Leu Val Ser Ile Asp Ser Lys Ala 
        115                 120                 125             


Ile Val Asp Gly Asn Leu Lys Leu Ile Leu Gly Leu Ile Trp Thr Leu 
    130                 135                 140                 


Ile Leu His Tyr Ser Ile Ser Met Pro Met Trp Asp Glu Glu Glu Asp 
145                 150                 155                 160 


Glu Glu Ala Lys Lys Gln Thr Pro Lys Gln Arg Leu Leu Gly Trp Ile 
                165                 170                 175     


Gln Asn Lys Leu Pro Gln Leu Pro Ile Thr Asn Phe Ser Arg Asp Trp 
            180                 185                 190         


Gln Ser Gly Arg Ala Leu Gly Ala Leu Val Asp Ser Cys Ala Pro Gly 
        195                 200                 205             


Leu Cys Pro Asp Trp Asp Ser Trp Asp Ala Ser Lys Pro Val Thr Asn 
    210                 215                 220                 


Ala Arg Glu Ala Met Gln Gln Ala Asp Asp Trp Leu Gly Ile Pro Gln 
225                 230                 235                 240 


Val Ile Thr Pro Glu Glu Ile Val Asp Pro Asn Val Asp Glu His Ser 
                245                 250                 255     


Val Met Thr Tyr Leu Ser Gln Phe Pro Lys Ala Lys Leu Lys Pro Gly 
            260                 265                 270         


Ala Pro Leu Arg Pro Lys Leu Asn Pro Lys Lys Ala Arg Ala Tyr Gly 
        275                 280                 285             


Pro Gly Ile Glu Pro Thr Gly Asn Met Val Lys Lys Arg Ala Glu Phe 
    290                 295                 300                 


Thr Val Glu Thr Arg Ser Ala Gly Gln Gly Glu Val Leu Val Tyr Val 
305                 310                 315                 320 


Glu Asp Pro Ala Gly His Gln Glu Glu Ala Lys Val Thr Ala Asn Asn 
                325                 330                 335     


Asp Lys Asn Arg Thr Phe Ser Val Trp Tyr Val Pro Glu Val Thr Gly 
            340                 345                 350         


Thr His Lys Val Thr Val Leu Phe Ala Gly Gln His Ile Ala Lys Ser 
        355                 360                 365             


Pro Phe Glu Val Tyr Val Asp Lys Ser Gln Gly Asp Ala Ser Lys Val 
    370                 375                 380                 


Thr Ala Gln Gly Pro Gly Leu Glu Pro Ser Gly Asn Ile Ala Asn Lys 
385                 390                 395                 400 


Thr Thr Tyr Phe Glu Ile Phe Thr Ala Gly Ala Gly Thr Gly Glu Val 
                405                 410                 415     


Glu Val Val Ile Gln Asp Pro Met Gly Gln Lys Gly Thr Val Glu Pro 
            420                 425                 430         


Gln Leu Glu Ala Arg Gly Asp Ser Thr Tyr Arg Cys Ser Tyr Gln Pro 
        435                 440                 445             


Thr Met Glu Gly Val His Thr Val His Val Thr Phe Ala Gly Val Pro 
    450                 455                 460                 


Ile Pro Arg Ser Pro Tyr Thr Val Thr Val Gly Gln Ala Cys Asn Pro 
465                 470                 475                 480 


Ser Ala Cys Arg Ala Val Gly Arg Gly Leu Gln Pro Lys Gly Val Arg 
                485                 490                 495     


Val Lys Glu Thr Ala Asp Phe Lys Val Tyr Thr Lys Gly Ala Gly Ser 
            500                 505                 510         


Gly Glu Leu Lys Val Thr Val Lys Gly Pro Lys Gly Glu Glu Arg Val 
        515                 520                 525             


Lys Gln Lys Asp Leu Gly Asp Gly Val Tyr Gly Phe Glu Tyr Tyr Pro 
    530                 535                 540                 


Met Val Pro Gly Thr Tyr Ile Val Thr Ile Thr Trp Gly Gly Gln Asn 
545                 550                 555                 560 


Ile Gly Arg Ser Pro Phe Glu Val Lys Val Gly Thr Glu Cys Gly Asn 
                565                 570                 575     


Gln Lys Val Arg Ala Trp Gly Pro Gly Leu Glu Gly Gly Val Val Gly 
            580                 585                 590         


Lys Ser Ala Asp Phe Val Val Glu Ala Ile Gly Asp Asp Val Gly Thr 
        595                 600                 605             


Leu Gly Phe Ser Val Glu Gly Pro Ser Gln Ala Lys Ile Glu Cys Asp 
    610                 615                 620                 


Asp Lys Gly Asp Gly Ser Cys Asp Val Arg Tyr Trp Pro Gln Glu Ala 
625                 630                 635                 640 


Gly Glu Tyr Ala Val His Val Leu Cys Asn Ser Glu Asp Ile Arg Leu 
                645                 650                 655     


Ser Pro Phe Met Ala Asp Ile Arg Asp Ala Pro Gln Asp Phe His Pro 
            660                 665                 670         


Asp Arg Val Lys Ala Arg Gly Pro Gly Leu Glu Lys Thr Gly Val Ala 
        675                 680                 685             


Val Asn Lys Pro Ala Glu Phe Thr Val Asp Ala Lys His Gly Gly Lys 
    690                 695                 700                 


Ala Pro Leu Arg Val Gln Val Gln Asp Asn Glu Gly Cys Pro Val Glu 
705                 710                 715                 720 


Ala Leu Val Lys Asp Asn Gly Asn Gly Thr Tyr Ser Cys Ser Tyr Val 
                725                 730                 735     


Pro Arg Lys Pro Val Lys His Thr Ala Met Val Ser Trp Gly Gly Val 
            740                 745                 750         


Ser Ile Pro Asn Ser Pro Phe Arg Val Asn Val Gly Ala Gly Ser His 
        755                 760                 765             


Pro Asn Lys Val Lys Val Tyr Gly Pro Gly Val Ala Lys Thr Gly Leu 
    770                 775                 780                 


Lys Ala His Glu Pro Thr Tyr Phe Thr Val Asp Cys Ala Glu Ala Gly 
785                 790                 795                 800 


Gln Gly Asp Val Ser Ile Gly Ile Lys Cys Ala Pro Gly Val Val Gly 
                805                 810                 815     


Pro Ala Glu Ala Asp Ile Asp Phe Asp Ile Ile Arg Asn Asp Asn Asp 
            820                 825                 830         


Thr Phe Thr Val Lys Tyr Thr Pro Arg Gly Ala Gly Ser Tyr Thr Ile 
        835                 840                 845             


Met Val Leu Phe Ala Asp Gln Ala Thr Pro Thr Ser Pro Ile Arg Val 
    850                 855                 860                 


Lys Val Glu Pro Ser His Asp Ala Ser Lys Val Lys Ala Glu Gly Pro 
865                 870                 875                 880 


Gly Leu Ser Arg Thr Gly Val Glu Leu Gly Lys Pro Thr His Phe Thr 
                885                 890                 895     


Val Asn Ala Lys Ala Ala Gly Lys Gly Lys Leu Asp Val Gln Phe Ser 
            900                 905                 910         


Gly Leu Thr Lys Gly Asp Ala Val Arg Asp Val Asp Ile Ile Asp His 
        915                 920                 925             


His Asp Asn Thr Tyr Thr Val Lys Tyr Thr Pro Val Gln Gln Gly Pro 
    930                 935                 940                 


Val Gly Val Asn Val Thr Tyr Gly Gly Asp Pro Ile Pro Lys Ser Pro 
945                 950                 955                 960 


Phe Ser Val Ala Val Ser Pro Ser Leu Asp Leu Ser Lys Ile Lys Val 
                965                 970                 975     


Ser Gly Leu Gly Glu Lys Val Asp Val Gly Lys Asp Gln Glu Phe Thr 
            980                 985                 990         


Val Lys Ser Lys Gly Ala Gly Gly  Gln Gly Lys Val Ala  Ser Lys Ile 
        995                 1000                 1005             


Val Gly  Pro Ser Gly Ala Ala  Val Pro Cys Lys Val  Glu Pro Gly 
    1010                 1015                 1020             


Leu Gly  Ala Asp Asn Ser Val  Val Arg Phe Leu Pro  Arg Glu Glu 
    1025                 1030                 1035             


Gly Pro  Tyr Glu Val Glu Val  Thr Tyr Asp Gly Val  Pro Val Pro 
    1040                 1045                 1050             


Gly Ser  Pro Phe Pro Leu Glu  Ala Val Ala Pro Thr  Lys Pro Ser 
    1055                 1060                 1065             


Lys Val  Lys Ala Phe Gly Pro  Gly Leu Gln Gly Gly  Ser Ala Gly 
    1070                 1075                 1080             


Ser Pro  Ala Arg Phe Thr Ile  Asp Thr Lys Gly Ala  Gly Thr Gly 
    1085                 1090                 1095             


Gly Leu  Gly Leu Thr Val Glu  Gly Pro Cys Glu Ala  Gln Leu Glu 
    1100                 1105                 1110             


Cys Leu  Asp Asn Gly Asp Gly  Thr Cys Ser Val Ser  Tyr Val Pro 
    1115                 1120                 1125             


Thr Glu  Pro Gly Asp Tyr Asn  Ile Asn Ile Leu Phe  Ala Asp Thr 
    1130                 1135                 1140             


His Ile  Pro Gly Ser Pro Phe  Lys Ala His Val Val  Pro Cys Phe 
    1145                 1150                 1155             


Asp Ala  Ser Lys Val Lys Cys  Ser Gly Pro Gly Leu  Glu Arg Ala 
    1160                 1165                 1170             


Thr Ala  Gly Glu Val Gly Gln  Phe Gln Val Asp Cys  Ser Ser Ala 
    1175                 1180                 1185             


Gly Ser  Ala Glu Leu Thr Ile  Glu Ile Cys Ser Glu  Ala Gly Leu 
    1190                 1195                 1200             


Pro Ala  Glu Val Tyr Ile Gln  Asp His Gly Asp Gly  Thr His Thr 
    1205                 1210                 1215             


Ile Thr  Tyr Ile Pro Leu Cys  Pro Gly Ala Tyr Thr  Val Thr Ile 
    1220                 1225                 1230             


Lys Tyr  Gly Gly Gln Pro Val  Pro Asn Phe Pro Ser  Lys Leu Gln 
    1235                 1240                 1245             


Val Glu  Pro Ala Val Asp Thr  Ser Gly Val Gln Cys  Tyr Gly Pro 
    1250                 1255                 1260             


Gly Ile  Glu Gly Gln Gly Val  Phe Arg Glu Ala Thr  Thr Glu Phe 
    1265                 1270                 1275             


Ser Val  Asp Ala Arg Ala Leu  Thr Gln Thr Gly Gly  Pro His Val 
    1280                 1285                 1290             


Lys Ala  Arg Val Ala Asn Pro  Ser Gly Asn Leu Thr  Glu Thr Tyr 
    1295                 1300                 1305             


Val Gln  Asp Arg Gly Asp Gly  Met Tyr Lys Val Glu  Tyr Thr Pro 
    1310                 1315                 1320             


Tyr Glu  Glu Gly Leu His Ser  Val Asp Val Thr Tyr  Asp Gly Ser 
    1325                 1330                 1335             


Pro Val  Pro Ser Ser Pro Phe  Gln Val Pro Val Thr  Glu Gly Cys 
    1340                 1345                 1350             


Asp Pro  Ser Arg Val Arg Val  His Gly Pro Gly Ile  Gln Ser Gly 
    1355                 1360                 1365             


Thr Thr  Asn Lys Pro Asn Lys  Phe Thr Val Glu Thr  Arg Gly Ala 
    1370                 1375                 1380             


Gly Thr  Gly Gly Leu Gly Leu  Ala Val Glu Gly Pro  Ser Glu Ala 
    1385                 1390                 1395             


Lys Met  Ser Cys Met Asp Asn  Lys Asp Gly Ser Cys  Ser Val Glu 
    1400                 1405                 1410             


Tyr Ile  Pro Tyr Glu Ala Gly  Thr Tyr Ser Leu Asn  Val Thr Tyr 
    1415                 1420                 1425             


Gly Gly  His Gln Val Pro Gly  Ser Pro Phe Lys Val  Pro Val His 
    1430                 1435                 1440             


Asp Val  Thr Asp Ala Ser Lys  Val Lys Cys Ser Gly  Pro Gly Leu 
    1445                 1450                 1455             


Ser Pro  Gly Met Val Arg Ala  Asn Leu Pro Gln Ser  Phe Gln Val 
    1460                 1465                 1470             


Asp Thr  Ser Lys Ala Gly Val  Ala Pro Leu Gln Val  Lys Val Gln 
    1475                 1480                 1485             


Gly Pro  Lys Gly Leu Val Glu  Pro Val Asp Val Val  Asp Asn Ala 
    1490                 1495                 1500             


Asp Gly  Thr Gln Thr Val Asn  Tyr Val Pro Ser Arg  Glu Gly Pro 
    1505                 1510                 1515             


Tyr Ser  Ile Ser Val Leu Tyr  Gly Asp Glu Glu Val  Pro Arg Ser 
    1520                 1525                 1530             


Pro Phe  Lys Val Lys Val Leu  Pro Thr His Asp Ala  Ser Lys Val 
    1535                 1540                 1545             


Lys Ala  Ser Gly Pro Gly Leu  Asn Thr Thr Gly Val  Pro Ala Ser 
    1550                 1555                 1560             


Leu Pro  Val Glu Phe Thr Ile  Asp Ala Lys Asp Ala  Gly Glu Gly 
    1565                 1570                 1575             


Leu Leu  Ala Val Gln Ile Thr  Asp Pro Glu Gly Lys  Pro Lys Lys 
    1580                 1585                 1590             


Thr His  Ile Gln Asp Asn His  Asp Gly Thr Tyr Thr  Val Ala Tyr 
    1595                 1600                 1605             


Val Pro  Asp Val Thr Gly Arg  Tyr Thr Ile Leu Ile  Lys Tyr Gly 
    1610                 1615                 1620             


Gly Asp  Glu Ile Pro Phe Ser  Pro Tyr Arg Val Arg  Ala Val Pro 
    1625                 1630                 1635             


Thr Gly  Asp Ala Ser Lys Cys  Thr Val Thr Val Ser  Ile Gly Gly 
    1640                 1645                 1650             


His Gly  Leu Gly Ala Gly Ile  Gly Pro Thr Ile Gln  Ile Gly Glu 
    1655                 1660                 1665             


Glu Thr  Val Ile Thr Val Asp  Thr Lys Ala Ala Gly  Lys Gly Lys 
    1670                 1675                 1680             


Val Thr  Cys Thr Val Cys Thr  Pro Asp Gly Ser Glu  Val Asp Val 
    1685                 1690                 1695             


Asp Val  Val Glu Asn Glu Asp  Gly Thr Phe Asp Ile  Phe Tyr Thr 
    1700                 1705                 1710             


Ala Pro  Gln Pro Gly Lys Tyr  Val Ile Cys Val Arg  Phe Gly Gly 
    1715                 1720                 1725             


Glu His  Val Pro Asn Ser Pro  Phe Gln Val Thr Ala  Leu Ala Gly 
    1730                 1735                 1740             


Asp Gln  Pro Ser Val Gln Pro  Pro Leu Arg Ser Gln  Gln Leu Ala 
    1745                 1750                 1755             


Pro Gln  Tyr Thr Tyr Ala Gln  Gly Gly Gln Gln Thr  Trp Ala Pro 
    1760                 1765                 1770             


Glu Arg  Pro Leu Val Gly Val  Asn Gly Leu Asp Val  Thr Ser Leu 
    1775                 1780                 1785             


Arg Pro  Phe Asp Leu Val Ile  Pro Phe Thr Ile Lys  Lys Gly Glu 
    1790                 1795                 1800             


Ile Thr  Gly Glu Val Arg Met  Pro Ser Gly Lys Val  Ala Gln Pro 
    1805                 1810                 1815             


Thr Ile  Thr Asp Asn Lys Asp  Gly Thr Val Thr Val  Arg Tyr Ala 
    1820                 1825                 1830             


Pro Ser  Glu Ala Gly Leu His  Glu Met Asp Ile Arg  Tyr Asp Asn 
    1835                 1840                 1845             


Met His  Ile Pro Gly Ser Pro  Leu Gln Phe Tyr Val  Asp Tyr Val 
    1850                 1855                 1860             


Asn Cys  Gly His Val Thr Ala  Tyr Gly Pro Gly Leu  Thr His Gly 
    1865                 1870                 1875             


Val Val  Asn Lys Pro Ala Thr  Phe Thr Val Asn Thr  Lys Asp Ala 
    1880                 1885                 1890             


Gly Glu  Gly Gly Leu Ser Leu  Ala Ile Glu Gly Pro  Ser Lys Ala 
    1895                 1900                 1905             


Glu Ile  Ser Cys Thr Asp Asn  Gln Asp Gly Thr Cys  Ser Val Ser 
    1910                 1915                 1920             


Tyr Leu  Pro Val Leu Pro Gly  Asp Tyr Ser Ile Leu  Val Lys Tyr 
    1925                 1930                 1935             


Asn Glu  Gln His Val Pro Gly  Ser Pro Phe Thr Ala  Arg Val Thr 
    1940                 1945                 1950             


Gly Asp  Asp Ser Met Arg Met  Ser His Leu Lys Val  Gly Ser Ala 
    1955                 1960                 1965             


Ala Asp  Ile Pro Ile Asn Ile  Ser Glu Thr Asp Leu  Ser Leu Leu 
    1970                 1975                 1980             


Thr Ala  Thr Val Val Pro Pro  Ser Gly Arg Glu Glu  Pro Cys Leu 
    1985                 1990                 1995             


Leu Lys  Arg Leu Arg Asn Gly  His Val Gly Ile Ser  Phe Val Pro 
    2000                 2005                 2010             


Lys Glu  Thr Gly Glu His Leu  Val His Val Lys Lys  Asn Gly Gln 
    2015                 2020                 2025             


His Val  Ala Ser Ser Pro Ile  Pro Val Val Ile Ser  Gln Ser Glu 
    2030                 2035                 2040             


Ile Gly  Asp Ala Ser Arg Val  Arg Val Ser Gly Gln  Gly Leu His 
    2045                 2050                 2055             


Glu Gly  His Thr Phe Glu Pro  Ala Glu Phe Ile Ile  Asp Thr Arg 
    2060                 2065                 2070             


Asp Ala  Gly Tyr Gly Gly Leu  Ser Leu Ser Ile Glu  Gly Pro Ser 
    2075                 2080                 2085             


Lys Val  Asp Ile Asn Thr Glu  Asp Leu Glu Asp Gly  Thr Cys Arg 
    2090                 2095                 2100             


Val Thr  Tyr Cys Pro Thr Glu  Pro Gly Asn Tyr Ile  Ile Asn Ile 
    2105                 2110                 2115             


Lys Phe  Ala Asp Gln His Val  Pro Gly Ser Pro Phe  Ser Val Lys 
    2120                 2125                 2130             


Val Thr  Gly Glu Gly Arg Val  Lys Glu Ser Ile Thr  Arg Arg Arg 
    2135                 2140                 2145             


Arg Ala  Pro Ser Val Ala Asn  Val Gly Ser His Cys  Asp Leu Ser 
    2150                 2155                 2160             


Leu Lys  Ile Pro Glu Ile Ser  Ile Gln Asp Met Thr  Ala Gln Val 
    2165                 2170                 2175             


Thr Ser  Pro Ser Gly Lys Thr  His Glu Ala Glu Ile  Val Glu Gly 
    2180                 2185                 2190             


Glu Asn  His Thr Tyr Cys Ile  Arg Phe Val Pro Ala  Glu Met Gly 
    2195                 2200                 2205             


Thr His  Thr Val Ser Val Lys  Tyr Lys Gly Gln His  Val Pro Gly 
    2210                 2215                 2220             


Ser Pro  Phe Gln Phe Thr Val  Gly Pro Leu Gly Glu  Gly Gly Ala 
    2225                 2230                 2235             


His Lys  Val Arg Ala Gly Gly  Pro Gly Leu Glu Arg  Ala Glu Ala 
    2240                 2245                 2250             


Gly Val  Pro Ala Glu Phe Ser  Ile Trp Thr Arg Glu  Ala Gly Ala 
    2255                 2260                 2265             


Gly Gly  Leu Ala Ile Ala Val  Glu Gly Pro Ser Lys  Ala Glu Ile 
    2270                 2275                 2280             


Ser Phe  Glu Asp Arg Lys Asp  Gly Ser Cys Gly Val  Ala Tyr Val 
    2285                 2290                 2295             


Val Gln  Glu Pro Gly Asp Tyr  Glu Val Ser Val Lys  Phe Asn Glu 
    2300                 2305                 2310             


Glu His  Ile Pro Asp Ser Pro  Phe Val Val Pro Val  Ala Ser Pro 
    2315                 2320                 2325             


Ser Gly  Asp Ala Arg Arg Leu  Thr Val Ser Ser Leu  Gln Glu Ser 
    2330                 2335                 2340             


Gly Leu  Lys Val Asn Gln Pro  Ala Ser Phe Ala Val  Ser Leu Asn 
    2345                 2350                 2355             


Gly Ala  Lys Gly Ala Ile Asp  Ala Lys Val His Ser  Pro Ser Gly 
    2360                 2365                 2370             


Ala Leu  Glu Glu Cys Tyr Val  Thr Glu Ile Asp Gln  Asp Lys Tyr 
    2375                 2380                 2385             


Ala Val  Arg Phe Ile Pro Arg  Glu Asn Gly Val Tyr  Leu Ile Asp 
    2390                 2395                 2400             


Val Lys  Phe Asn Gly Thr His  Ile Pro Gly Ser Pro  Phe Lys Ile 
    2405                 2410                 2415             


Arg Val  Gly Glu Pro Gly His  Gly Gly Asp Pro Gly  Leu Val Ser 
    2420                 2425                 2430             


Ala Tyr  Gly Ala Gly Leu Glu  Gly Gly Val Thr Gly  Asn Pro Ala 
    2435                 2440                 2445             


Glu Phe  Val Val Asn Thr Ser  Asn Ala Gly Ala Gly  Ala Leu Ser 
    2450                 2455                 2460             


Val Thr  Ile Asp Gly Pro Ser  Lys Val Lys Met Asp  Cys Gln Glu 
    2465                 2470                 2475             


Cys Pro  Glu Gly Tyr Arg Val  Thr Tyr Thr Pro Met  Ala Pro Gly 
    2480                 2485                 2490             


Ser Tyr  Leu Ile Ser Ile Lys  Tyr Gly Gly Pro Tyr  His Ile Gly 
    2495                 2500                 2505             


Gly Ser  Pro Phe Lys Ala Lys  Val Thr Gly Pro Arg  Leu Val Ser 
    2510                 2515                 2520             


Asn His  Ser Leu His Glu Thr  Ser Ser Val Phe Val  Asp Ser Leu 
    2525                 2530                 2535             


Thr Lys  Ala Thr Cys Ala Pro  Gln His Gly Ala Pro  Gly Pro Gly 
    2540                 2545                 2550             


Pro Ala  Asp Ala Ser Lys Val  Val Ala Lys Gly Leu  Gly Leu Ser 
    2555                 2560                 2565             


Lys Ala  Tyr Val Gly Gln Lys  Ser Ser Phe Thr Val  Asp Cys Ser 
    2570                 2575                 2580             


Lys Ala  Gly Asn Asn Met Leu  Leu Val Gly Val His  Gly Pro Arg 
    2585                 2590                 2595             


Thr Pro  Cys Glu Glu Ile Leu  Val Lys His Val Gly  Ser Arg Leu 
    2600                 2605                 2610             


Tyr Ser  Val Ser Tyr Leu Leu  Lys Asp Lys Gly Glu  Tyr Thr Leu 
    2615                 2620                 2625             


Val Val  Lys Trp Gly His Glu  His Ile Pro Gly Ser  Pro Tyr Arg 
    2630                 2635                 2640             


Val Val  Val Pro 
    2645         


<210>  87
<211>  1140
<212>  DNA
<213>  Homo sapiens

<400>  87
atgacgttgc agccccgctg cgaggacgta gagacggccg agggggtagc tttaactgtg       60

acgggtgtcg cccaggtgaa gatcatgacg gagaaggaac tcctggccgt ggcttgtgag      120

cagtttctgg gtaagaatgt gcaggacatc aaaaacgtcg tcctgcagac cctggaggga      180

catctgcgct ccatcctcgg gaccctgaca gtggagcaga tttatcagga ccgggaccag      240

tttgccaagc tggtgcggga ggtggcagcc cctgatgttg gccgcatggg cattgagatc      300

ctcagcttca ccatcaagga cgtgtatgac aaagtggact atctgagctc cctgggcaag      360

acgcagactg ccgtggtgca gagagatgct gacattggcg tggccgaggc tgaacgggac      420

gcaggcatcc gggaagctga gtgcaagaag gagatgctgg atgtgaagtt catggcagac      480

accaagattg ctgactctaa gcgagccttc gagctgcaaa agtcagcctt cagtgaggag      540

gttaacatca agacagctga ggcccagttg gcctatgagc tgcagggggc ccgtgaacag      600

cagaagatcc ggcaggaaga gattgagatt gaggttgtgc agcgcaagaa acagattgcc      660

gtggaggcac aggagatcct gcgtacggac aaggagctca tcgctacagt gcgccggcct      720

gccgaggccg aggcccaccg catccagcag attgccgagg gtgaaaaggt gaagcaggtc      780

ctcttggcac aggcagaggc tgagaagatc cgcaaaatcg gggaggcgga agcggcagtc      840

atcgaggcga tgggcaaggc agaggctgag cggatgaagc tcaaggcaga agcctaccag      900

aaatacgggg atgcagccaa gatggccttg gtgctagagg ccctgcccca gattgctgcc      960

aaaatcgctg ccccacttac caaggtcgat gagattgtgg tcctcagtgg agacaacagt     1020

aaggtcacat cagaagtgaa ccgactgctg gccgagctgc ctgcctctgt gcatgccctc     1080

acaggcgtgg acctgtctaa gatacccctg atcaagaagg ccactggtgt gcaggtgtga     1140


<210>  88
<211>  379
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Thr Leu Gln Pro Arg Cys Glu Asp Val Glu Thr Ala Glu Gly Val 
1               5                   10                  15      


Ala Leu Thr Val Thr Gly Val Ala Gln Val Lys Ile Met Thr Glu Lys 
            20                  25                  30          


Glu Leu Leu Ala Val Ala Cys Glu Gln Phe Leu Gly Lys Asn Val Gln 
        35                  40                  45              


Asp Ile Lys Asn Val Val Leu Gln Thr Leu Glu Gly His Leu Arg Ser 
    50                  55                  60                  


Ile Leu Gly Thr Leu Thr Val Glu Gln Ile Tyr Gln Asp Arg Asp Gln 
65                  70                  75                  80  


Phe Ala Lys Leu Val Arg Glu Val Ala Ala Pro Asp Val Gly Arg Met 
                85                  90                  95      


Gly Ile Glu Ile Leu Ser Phe Thr Ile Lys Asp Val Tyr Asp Lys Val 
            100                 105                 110         


Asp Tyr Leu Ser Ser Leu Gly Lys Thr Gln Thr Ala Val Val Gln Arg 
        115                 120                 125             


Asp Ala Asp Ile Gly Val Ala Glu Ala Glu Arg Asp Ala Gly Ile Arg 
    130                 135                 140                 


Glu Ala Glu Cys Lys Lys Glu Met Leu Asp Val Lys Phe Met Ala Asp 
145                 150                 155                 160 


Thr Lys Ile Ala Asp Ser Lys Arg Ala Phe Glu Leu Gln Lys Ser Ala 
                165                 170                 175     


Phe Ser Glu Glu Val Asn Ile Lys Thr Ala Glu Ala Gln Leu Ala Tyr 
            180                 185                 190         


Glu Leu Gln Gly Ala Arg Glu Gln Gln Lys Ile Arg Gln Glu Glu Ile 
        195                 200                 205             


Glu Ile Glu Val Val Gln Arg Lys Lys Gln Ile Ala Val Glu Ala Gln 
    210                 215                 220                 


Glu Ile Leu Arg Thr Asp Lys Glu Leu Ile Ala Thr Val Arg Arg Pro 
225                 230                 235                 240 


Ala Glu Ala Glu Ala His Arg Ile Gln Gln Ile Ala Glu Gly Glu Lys 
                245                 250                 255     


Val Lys Gln Val Leu Leu Ala Gln Ala Glu Ala Glu Lys Ile Arg Lys 
            260                 265                 270         


Ile Gly Glu Ala Glu Ala Ala Val Ile Glu Ala Met Gly Lys Ala Glu 
        275                 280                 285             


Ala Glu Arg Met Lys Leu Lys Ala Glu Ala Tyr Gln Lys Tyr Gly Asp 
    290                 295                 300                 


Ala Ala Lys Met Ala Leu Val Leu Glu Ala Leu Pro Gln Ile Ala Ala 
305                 310                 315                 320 


Lys Ile Ala Ala Pro Leu Thr Lys Val Asp Glu Ile Val Val Leu Ser 
                325                 330                 335     


Gly Asp Asn Ser Lys Val Thr Ser Glu Val Asn Arg Leu Leu Ala Glu 
            340                 345                 350         


Leu Pro Ala Ser Val His Ala Leu Thr Gly Val Asp Leu Ser Lys Ile 
        355                 360                 365             


Pro Leu Ile Lys Lys Ala Thr Gly Val Gln Val 
    370                 375                 


<210>  89
<211>  753
<212>  DNA
<213>  Homo sapiens

<400>  89
atggcggcag ggaccagcag ttactgggaa gatctcagga aacaggctcg acagctggaa       60

aatgaacttg acctgaaact agtttccttc agcaaactat gtacaagtta cagtcatagc      120

agtacccgag atggaagacg cgacaggtat agttctgata caacacccct tttaaatgga      180

tcaagccaag acagaatgtt tgagacaatg gcgattgaga ttgaacaact tttggcaagg      240

cttacagggg taaatgataa aatggcagaa tataccaaca gtgcaggtgt cccctccttg      300

aatgcagccc tgatgcatac attacagcgg catagagaca tattgcagga ttatacacat      360

gaattccata aaaccaaagc aaactttatg gcaatacggg aaagggagaa tcttatggga      420

tcagtacgaa aagatattga gtcatataaa agtgggtctg gagtaaacaa cagaagaact      480

gagctatttt tgaaagaaca tgaccacctt cgaaactcag atcgtctgat agaagagaca      540

ataagcattg ctatggcaac aaaagaaaat atgacttcac agagaggaat gttgaagtca      600

attcacagca aaatgaacac tttggccaat cgttttcctg ctgtaaacag cctgatccag      660

aggatcaacc tgaggaagcg gcgggactcg ctcatcctag ggggtgttat tgggatctgt      720

accatcctgt tgctgctgta tgcgttccat tga                                   753


<210>  90
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Ala Ala Gly Thr Ser Ser Tyr Trp Glu Asp Leu Arg Lys Gln Ala 
1               5                   10                  15      


Arg Gln Leu Glu Asn Glu Leu Asp Leu Lys Leu Val Ser Phe Ser Lys 
            20                  25                  30          


Leu Cys Thr Ser Tyr Ser His Ser Ser Thr Arg Asp Gly Arg Arg Asp 
        35                  40                  45              


Arg Tyr Ser Ser Asp Thr Thr Pro Leu Leu Asn Gly Ser Ser Gln Asp 
    50                  55                  60                  


Arg Met Phe Glu Thr Met Ala Ile Glu Ile Glu Gln Leu Leu Ala Arg 
65                  70                  75                  80  


Leu Thr Gly Val Asn Asp Lys Met Ala Glu Tyr Thr Asn Ser Ala Gly 
                85                  90                  95      


Val Pro Ser Leu Asn Ala Ala Leu Met His Thr Leu Gln Arg His Arg 
            100                 105                 110         


Asp Ile Leu Gln Asp Tyr Thr His Glu Phe His Lys Thr Lys Ala Asn 
        115                 120                 125             


Phe Met Ala Ile Arg Glu Arg Glu Asn Leu Met Gly Ser Val Arg Lys 
    130                 135                 140                 


Asp Ile Glu Ser Tyr Lys Ser Gly Ser Gly Val Asn Asn Arg Arg Thr 
145                 150                 155                 160 


Glu Leu Phe Leu Lys Glu His Asp His Leu Arg Asn Ser Asp Arg Leu 
                165                 170                 175     


Ile Glu Glu Thr Ile Ser Ile Ala Met Ala Thr Lys Glu Asn Met Thr 
            180                 185                 190         


Ser Gln Arg Gly Met Leu Lys Ser Ile His Ser Lys Met Asn Thr Leu 
        195                 200                 205             


Ala Asn Arg Phe Pro Ala Val Asn Ser Leu Ile Gln Arg Ile Asn Leu 
    210                 215                 220                 


Arg Lys Arg Arg Asp Ser Leu Ile Leu Gly Gly Val Ile Gly Ile Cys 
225                 230                 235                 240 


Thr Ile Leu Leu Leu Leu Tyr Ala Phe His 
                245                 250 


<210>  91
<211>  1599
<212>  DNA
<213>  Homo sapiens

<400>  91
atggagctgg atctgtctcc acctcatctt agcagctctc cggaagacct ttgcccagcc       60

cctgggaccc ctcctgggac tccccggccc cctgataccc ctctgcctga ggaggtaaag      120

aggtcccagc ctctcctcat cccaaccacc ggcaggaaac ttcgagagga ggagaggcgt      180

gccacctccc tcccctctat ccccaacccc ttccctgagc tctgcagtcc tccctcacag      240

agcccaattc tcgggggccc ctccagtgca agggggctgc tcccccgcga tgccagccgc      300

ccccatgtag taaaggtgta cagtgaggat ggggcctgca ggtctgtgga ggtggcagca      360

ggtgccacag ctcgccacgt gtgtgaaatg ctggtgcagc gagctcacgc cttgagcgac      420

gagacctggg ggctggtgga gtgccacccc cacctagcac tggagcgggg tttggaggac      480

cacgagtccg tggtggaagt gcaggctgcc tggcccgtgg gcggagatag ccgcttcgtc      540

ttccggaaaa acttcgccaa gtacgaactg ttcaagagct ccccacactc cctgttccca      600

gaaaaaatgg tctccagctg tctcgatgca cacactggta tatcccatga agacctcatc      660

cagaacttcc tgaatgctgg cagctttcct gagatccagg gctttctgca gctgcggggt      720

tcaggacgga agctttggaa acgctttttc tgcttcttgc gccgatctgg cctctattac      780

tccaccaagg gcacctctaa ggatccgagg cacctgcagt acgtggcaga tgtgaacgag      840

tccaacgtgt acgtggtgac gcagggccgc aagctctacg ggatgcccac tgacttcggt      900

ttctgtgtca agcccaacaa gcttcgaaat ggccacaagg ggcttcggat cttctgcagt      960

gaagatgagc agagccgcac ctgctggctg gctgccttcc gcctcttcaa gtacggggtg     1020

cagctgtaca agaattacca gcaggcacag tctcgccatc tgcatccatc ttgtttgggc     1080

tccccaccct tgagaagtgc ctcagataat accctggtgg ccatggactt ctctggccat     1140

gctgggcgtg tcattgagaa cccccgggag gctctgagtg tggccctgga ggaggcccag     1200

gcctggagga agaagacaaa ccaccgcctc agcctgccca tgccagcctc cggcacgagc     1260

ctcagtgcag ccatccaccg cacccaactc tggttccacg ggcgcatttc ccgtgaggag     1320

agccagcggc ttattggaca gcagggcttg gtagacggcc tgttcctggt ccgggagagt     1380

cagcggaacc cccagggctt tgtcctctct ttgtgccacc tgcagaaagt gaagcattat     1440

ctcatcctgc cgagcgagga ggagggccgc ctgtacttca gcatggatga tggccagacc     1500

cgcttcactg acctgctgca gctcgtggag ttccaccagc tgaaccgcgg catcctgccg     1560

tgcttgctgc gccattgctg cacgcgggtg gccctctga                            1599


<210>  92
<211>  532
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Glu Leu Asp Leu Ser Pro Pro His Leu Ser Ser Ser Pro Glu Asp 
1               5                   10                  15      


Leu Cys Pro Ala Pro Gly Thr Pro Pro Gly Thr Pro Arg Pro Pro Asp 
            20                  25                  30          


Thr Pro Leu Pro Glu Glu Val Lys Arg Ser Gln Pro Leu Leu Ile Pro 
        35                  40                  45              


Thr Thr Gly Arg Lys Leu Arg Glu Glu Glu Arg Arg Ala Thr Ser Leu 
    50                  55                  60                  


Pro Ser Ile Pro Asn Pro Phe Pro Glu Leu Cys Ser Pro Pro Ser Gln 
65                  70                  75                  80  


Ser Pro Ile Leu Gly Gly Pro Ser Ser Ala Arg Gly Leu Leu Pro Arg 
                85                  90                  95      


Asp Ala Ser Arg Pro His Val Val Lys Val Tyr Ser Glu Asp Gly Ala 
            100                 105                 110         


Cys Arg Ser Val Glu Val Ala Ala Gly Ala Thr Ala Arg His Val Cys 
        115                 120                 125             


Glu Met Leu Val Gln Arg Ala His Ala Leu Ser Asp Glu Thr Trp Gly 
    130                 135                 140                 


Leu Val Glu Cys His Pro His Leu Ala Leu Glu Arg Gly Leu Glu Asp 
145                 150                 155                 160 


His Glu Ser Val Val Glu Val Gln Ala Ala Trp Pro Val Gly Gly Asp 
                165                 170                 175     


Ser Arg Phe Val Phe Arg Lys Asn Phe Ala Lys Tyr Glu Leu Phe Lys 
            180                 185                 190         


Ser Ser Pro His Ser Leu Phe Pro Glu Lys Met Val Ser Ser Cys Leu 
        195                 200                 205             


Asp Ala His Thr Gly Ile Ser His Glu Asp Leu Ile Gln Asn Phe Leu 
    210                 215                 220                 


Asn Ala Gly Ser Phe Pro Glu Ile Gln Gly Phe Leu Gln Leu Arg Gly 
225                 230                 235                 240 


Ser Gly Arg Lys Leu Trp Lys Arg Phe Phe Cys Phe Leu Arg Arg Ser 
                245                 250                 255     


Gly Leu Tyr Tyr Ser Thr Lys Gly Thr Ser Lys Asp Pro Arg His Leu 
            260                 265                 270         


Gln Tyr Val Ala Asp Val Asn Glu Ser Asn Val Tyr Val Val Thr Gln 
        275                 280                 285             


Gly Arg Lys Leu Tyr Gly Met Pro Thr Asp Phe Gly Phe Cys Val Lys 
    290                 295                 300                 


Pro Asn Lys Leu Arg Asn Gly His Lys Gly Leu Arg Ile Phe Cys Ser 
305                 310                 315                 320 


Glu Asp Glu Gln Ser Arg Thr Cys Trp Leu Ala Ala Phe Arg Leu Phe 
                325                 330                 335     


Lys Tyr Gly Val Gln Leu Tyr Lys Asn Tyr Gln Gln Ala Gln Ser Arg 
            340                 345                 350         


His Leu His Pro Ser Cys Leu Gly Ser Pro Pro Leu Arg Ser Ala Ser 
        355                 360                 365             


Asp Asn Thr Leu Val Ala Met Asp Phe Ser Gly His Ala Gly Arg Val 
    370                 375                 380                 


Ile Glu Asn Pro Arg Glu Ala Leu Ser Val Ala Leu Glu Glu Ala Gln 
385                 390                 395                 400 


Ala Trp Arg Lys Lys Thr Asn His Arg Leu Ser Leu Pro Met Pro Ala 
                405                 410                 415     


Ser Gly Thr Ser Leu Ser Ala Ala Ile His Arg Thr Gln Leu Trp Phe 
            420                 425                 430         


His Gly Arg Ile Ser Arg Glu Glu Ser Gln Arg Leu Ile Gly Gln Gln 
        435                 440                 445             


Gly Leu Val Asp Gly Leu Phe Leu Val Arg Glu Ser Gln Arg Asn Pro 
    450                 455                 460                 


Gln Gly Phe Val Leu Ser Leu Cys His Leu Gln Lys Val Lys His Tyr 
465                 470                 475                 480 


Leu Ile Leu Pro Ser Glu Glu Glu Gly Arg Leu Tyr Phe Ser Met Asp 
                485                 490                 495     


Asp Gly Gln Thr Arg Phe Thr Asp Leu Leu Gln Leu Val Glu Phe His 
            500                 505                 510         


Gln Leu Asn Arg Gly Ile Leu Pro Cys Leu Leu Arg His Cys Cys Thr 
        515                 520                 525             


Arg Val Ala Leu 
    530         


<210>  93
<211>  2349
<212>  DNA
<213>  Homo sapiens

<400>  93
atggctccgc accgccccgc gcccgcgctg ctttgcgcgc tgtccctggc gctgtgcgcg       60

ctgtcgctgc ccgtccgcgc ggccactgcg tcgcgggggg cgtcccaggc gggggcgccc      120

caggggcggg tgcccgaggc gcggcccaac agcatggtgg tggaacaccc cgagttcctc      180

aaggcaggga aggagcctgg cctgcagatc tggcgtgtgg agaagttcga tctggtgccc      240

gtgcccacca acctttatgg agacttcttc acgggcgacg cctacgtcat cctgaagaca      300

gtgcagctga ggaacggaaa tctgcagtat gacctccact actggctggg caatgagtgc      360

agccaggatg agagcggggc ggccgccatc tttaccgtgc agctggatga ctacctgaac      420

ggccgggccg tgcagcaccg tgaggtccag ggcttcgagt cggccacctt cctaggctac      480

ttcaagtctg gcctgaagta caagaaagga ggtgtggcat caggattcaa gcacgtggta      540

cccaacgagg tggtggtgca gagactcttc caggtcaaag ggcggcgtgt ggtccgtgcc      600

accgaggtac ctgtgtcctg ggagagcttc aacaatggcg actgcttcat cctggacctg      660

ggcaacaaca tccaccagtg gtgtggttcc aacagcaatc ggtatgaaag actgaaggcc      720

acacaggtgt ccaagggcat ccgggacaac gagcggagtg gccgggcccg agtgcacgtg      780

tctgaggagg gcactgagcc cgaggcgatg ctccaggtgc tgggccccaa gccggctctg      840

cctgcaggta ccgaggacac cgccaaggag gatgcggcca accgcaagct ggccaagctc      900

tacaaggtct ccaatggtgc agggaccatg tccgtctccc tcgtggctga tgagaacccc      960

ttcgcccagg gggccctgaa gtcagaggac tgcttcatcc tggaccacgg caaagatggg     1020

aaaatctttg tctggaaagg caagcaggca aacacggagg agaggaaggc tgccctcaaa     1080

acagcctctg acttcatcac caagatggac taccccaagc agactcaggt ctcggtcctt     1140

cctgagggcg gtgagacccc actgttcaag cagttcttca agaactggcg ggacccagac     1200

cagacagatg gcctgggctt gtcctacctt tccagccata tcgccaacgt ggagcgggtg     1260

cccttcgacg ccgccaccct gcacacctcc actgccatgg ccgcccagca cggcatggat     1320

gacgatggca caggccagaa acagatctgg agaatcgaag gttccaacaa ggtgcccgtg     1380

gaccctgcca catatggaca gttctatgga ggcgacagct acatcattct gtacaactac     1440

cgccatggtg gccgccaggg gcagataatc tataactggc agggtgccca gtctacccag     1500

gatgaggtcg ctgcatctgc catcctgact gctcagctgg atgaggagct gggaggtacc     1560

cctgtccaga gccgtgtggt ccaaggcaag gagcccgccc acctcatgag cctgtttggt     1620

gggaagccca tgatcatcta caagggcggc acctcccgcg agggcgggca gacagcccct     1680

gccagcaccc gcctcttcca ggtccgcgcc aacagcgctg gagccacccg ggctgttgag     1740

gtattgccta aggctggtgc actgaactcc aacgatgcct ttgttctgaa aaccccctca     1800

gccgcctacc tgtgggtggg tacaggagcc agcgaggcag agaagacggg ggcccaggag     1860

ctgctcaggg tgctgcgggc ccaacctgtg caggtggcag aaggcagcga gccagatggc     1920

ttctgggagg ccctgggcgg gaaggctgcc taccgcacat ccccacggct gaaggacaag     1980

aagatggatg cccatcctcc tcgcctcttt gcctgctcca acaagattgg acgttttgtg     2040

atcgaagagg ttcctggtga gctcatgcag gaagacctgg caacggatga cgtcatgctt     2100

ctggacacct gggaccaggt ctttgtctgg gttggaaagg attctcaaga agaagaaaag     2160

acagaagcct tgacttctgc taagcggtac atcgagacgg acccagccaa tcgggatcgg     2220

cggacgccca tcaccgtggt gaagcaaggc tttgagcctc cctcctttgt gggctggttc     2280

cttggctggg atgatgatta ctggtctgtg gaccccttgg acagggccat ggctgagctg     2340

gctgcctga                                                             2349


<210>  94
<211>  782
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Ala Pro His Arg Pro Ala Pro Ala Leu Leu Cys Ala Leu Ser Leu 
1               5                   10                  15      


Ala Leu Cys Ala Leu Ser Leu Pro Val Arg Ala Ala Thr Ala Ser Arg 
            20                  25                  30          


Gly Ala Ser Gln Ala Gly Ala Pro Gln Gly Arg Val Pro Glu Ala Arg 
        35                  40                  45              


Pro Asn Ser Met Val Val Glu His Pro Glu Phe Leu Lys Ala Gly Lys 
    50                  55                  60                  


Glu Pro Gly Leu Gln Ile Trp Arg Val Glu Lys Phe Asp Leu Val Pro 
65                  70                  75                  80  


Val Pro Thr Asn Leu Tyr Gly Asp Phe Phe Thr Gly Asp Ala Tyr Val 
                85                  90                  95      


Ile Leu Lys Thr Val Gln Leu Arg Asn Gly Asn Leu Gln Tyr Asp Leu 
            100                 105                 110         


His Tyr Trp Leu Gly Asn Glu Cys Ser Gln Asp Glu Ser Gly Ala Ala 
        115                 120                 125             


Ala Ile Phe Thr Val Gln Leu Asp Asp Tyr Leu Asn Gly Arg Ala Val 
    130                 135                 140                 


Gln His Arg Glu Val Gln Gly Phe Glu Ser Ala Thr Phe Leu Gly Tyr 
145                 150                 155                 160 


Phe Lys Ser Gly Leu Lys Tyr Lys Lys Gly Gly Val Ala Ser Gly Phe 
                165                 170                 175     


Lys His Val Val Pro Asn Glu Val Val Val Gln Arg Leu Phe Gln Val 
            180                 185                 190         


Lys Gly Arg Arg Val Val Arg Ala Thr Glu Val Pro Val Ser Trp Glu 
        195                 200                 205             


Ser Phe Asn Asn Gly Asp Cys Phe Ile Leu Asp Leu Gly Asn Asn Ile 
    210                 215                 220                 


His Gln Trp Cys Gly Ser Asn Ser Asn Arg Tyr Glu Arg Leu Lys Ala 
225                 230                 235                 240 


Thr Gln Val Ser Lys Gly Ile Arg Asp Asn Glu Arg Ser Gly Arg Ala 
                245                 250                 255     


Arg Val His Val Ser Glu Glu Gly Thr Glu Pro Glu Ala Met Leu Gln 
            260                 265                 270         


Val Leu Gly Pro Lys Pro Ala Leu Pro Ala Gly Thr Glu Asp Thr Ala 
        275                 280                 285             


Lys Glu Asp Ala Ala Asn Arg Lys Leu Ala Lys Leu Tyr Lys Val Ser 
    290                 295                 300                 


Asn Gly Ala Gly Thr Met Ser Val Ser Leu Val Ala Asp Glu Asn Pro 
305                 310                 315                 320 


Phe Ala Gln Gly Ala Leu Lys Ser Glu Asp Cys Phe Ile Leu Asp His 
                325                 330                 335     


Gly Lys Asp Gly Lys Ile Phe Val Trp Lys Gly Lys Gln Ala Asn Thr 
            340                 345                 350         


Glu Glu Arg Lys Ala Ala Leu Lys Thr Ala Ser Asp Phe Ile Thr Lys 
        355                 360                 365             


Met Asp Tyr Pro Lys Gln Thr Gln Val Ser Val Leu Pro Glu Gly Gly 
    370                 375                 380                 


Glu Thr Pro Leu Phe Lys Gln Phe Phe Lys Asn Trp Arg Asp Pro Asp 
385                 390                 395                 400 


Gln Thr Asp Gly Leu Gly Leu Ser Tyr Leu Ser Ser His Ile Ala Asn 
                405                 410                 415     


Val Glu Arg Val Pro Phe Asp Ala Ala Thr Leu His Thr Ser Thr Ala 
            420                 425                 430         


Met Ala Ala Gln His Gly Met Asp Asp Asp Gly Thr Gly Gln Lys Gln 
        435                 440                 445             


Ile Trp Arg Ile Glu Gly Ser Asn Lys Val Pro Val Asp Pro Ala Thr 
    450                 455                 460                 


Tyr Gly Gln Phe Tyr Gly Gly Asp Ser Tyr Ile Ile Leu Tyr Asn Tyr 
465                 470                 475                 480 


Arg His Gly Gly Arg Gln Gly Gln Ile Ile Tyr Asn Trp Gln Gly Ala 
                485                 490                 495     


Gln Ser Thr Gln Asp Glu Val Ala Ala Ser Ala Ile Leu Thr Ala Gln 
            500                 505                 510         


Leu Asp Glu Glu Leu Gly Gly Thr Pro Val Gln Ser Arg Val Val Gln 
        515                 520                 525             


Gly Lys Glu Pro Ala His Leu Met Ser Leu Phe Gly Gly Lys Pro Met 
    530                 535                 540                 


Ile Ile Tyr Lys Gly Gly Thr Ser Arg Glu Gly Gly Gln Thr Ala Pro 
545                 550                 555                 560 


Ala Ser Thr Arg Leu Phe Gln Val Arg Ala Asn Ser Ala Gly Ala Thr 
                565                 570                 575     


Arg Ala Val Glu Val Leu Pro Lys Ala Gly Ala Leu Asn Ser Asn Asp 
            580                 585                 590         


Ala Phe Val Leu Lys Thr Pro Ser Ala Ala Tyr Leu Trp Val Gly Thr 
        595                 600                 605             


Gly Ala Ser Glu Ala Glu Lys Thr Gly Ala Gln Glu Leu Leu Arg Val 
    610                 615                 620                 


Leu Arg Ala Gln Pro Val Gln Val Ala Glu Gly Ser Glu Pro Asp Gly 
625                 630                 635                 640 


Phe Trp Glu Ala Leu Gly Gly Lys Ala Ala Tyr Arg Thr Ser Pro Arg 
                645                 650                 655     


Leu Lys Asp Lys Lys Met Asp Ala His Pro Pro Arg Leu Phe Ala Cys 
            660                 665                 670         


Ser Asn Lys Ile Gly Arg Phe Val Ile Glu Glu Val Pro Gly Glu Leu 
        675                 680                 685             


Met Gln Glu Asp Leu Ala Thr Asp Asp Val Met Leu Leu Asp Thr Trp 
    690                 695                 700                 


Asp Gln Val Phe Val Trp Val Gly Lys Asp Ser Gln Glu Glu Glu Lys 
705                 710                 715                 720 


Thr Glu Ala Leu Thr Ser Ala Lys Arg Tyr Ile Glu Thr Asp Pro Ala 
                725                 730                 735     


Asn Arg Asp Arg Arg Thr Pro Ile Thr Val Val Lys Gln Gly Phe Glu 
            740                 745                 750         


Pro Pro Ser Phe Val Gly Trp Phe Leu Gly Trp Asp Asp Asp Tyr Trp 
        755                 760                 765             


Ser Val Asp Pro Leu Asp Arg Ala Met Ala Glu Leu Ala Ala 
    770                 775                 780         


<210>  95
<211>  951
<212>  DNA
<213>  Homo sapiens

<400>  95
atggcgtcta ccagccgttt ggatgctctt ccaagagtca catgtccaaa ccatccagat       60

gcgattttag tggaggacta cagagccggt gatatgatct gtcctgaatg tggcttggtt      120

gtaggtgacc gggttattga tgtgggatct gaatggcgaa ctttcagcaa tgacaaagca      180

acaaaagatc catctcgagt tggagattct cagaatcctc ttctgagtga tggagatttg      240

tctaccatga ttggcaaggg cacaggagct gcaagttttg acgaatttgg caattctaag      300

taccagaatc ggagaacaat gagcagttct gatcgggcaa tgatgaatgc attcaaagaa      360

atcactacca tggcagacag aatcaatcta cctcgaaata tagttgatcg aacaaataat      420

ttattcaagc aagtatatga acagaagagc ctgaagggaa gagctaatga tgctatagct      480

tctgcttgtc tctatattgc ctgtagacaa gaaggggttc ctaggacatt taaagaaata      540

tgtgccgtat cacgaatttc taagaaagaa attggtcggt gttttaaact tattttgaaa      600

gcgctagaaa ccagtgtgga tttgattaca actggggact tcatgtccag gttctgttcc      660

aacctttgtc ttcctaaaca agtacagatg gcagctacac atatagcccg taaagctgtg      720

gaactggact tggttcctgg gaggagcccc atctctgtgg cagcggcagc tatttacatg      780

gcctcacagg catcagctga aaagaggacc caaaaagaaa ttggagatat tgctggtgtt      840

gctgatgtta caatcagaca gtcctataga ctgatctatc ctcgagcccc agatctgttt      900

cctacagact tcaaatttga caccccagtg gacaaactac cacagctata a               951


<210>  96
<211>  316
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Ala Ser Thr Ser Arg Leu Asp Ala Leu Pro Arg Val Thr Cys Pro 
1               5                   10                  15      


Asn His Pro Asp Ala Ile Leu Val Glu Asp Tyr Arg Ala Gly Asp Met 
            20                  25                  30          


Ile Cys Pro Glu Cys Gly Leu Val Val Gly Asp Arg Val Ile Asp Val 
        35                  40                  45              


Gly Ser Glu Trp Arg Thr Phe Ser Asn Asp Lys Ala Thr Lys Asp Pro 
    50                  55                  60                  


Ser Arg Val Gly Asp Ser Gln Asn Pro Leu Leu Ser Asp Gly Asp Leu 
65                  70                  75                  80  


Ser Thr Met Ile Gly Lys Gly Thr Gly Ala Ala Ser Phe Asp Glu Phe 
                85                  90                  95      


Gly Asn Ser Lys Tyr Gln Asn Arg Arg Thr Met Ser Ser Ser Asp Arg 
            100                 105                 110         


Ala Met Met Asn Ala Phe Lys Glu Ile Thr Thr Met Ala Asp Arg Ile 
        115                 120                 125             


Asn Leu Pro Arg Asn Ile Val Asp Arg Thr Asn Asn Leu Phe Lys Gln 
    130                 135                 140                 


Val Tyr Glu Gln Lys Ser Leu Lys Gly Arg Ala Asn Asp Ala Ile Ala 
145                 150                 155                 160 


Ser Ala Cys Leu Tyr Ile Ala Cys Arg Gln Glu Gly Val Pro Arg Thr 
                165                 170                 175     


Phe Lys Glu Ile Cys Ala Val Ser Arg Ile Ser Lys Lys Glu Ile Gly 
            180                 185                 190         


Arg Cys Phe Lys Leu Ile Leu Lys Ala Leu Glu Thr Ser Val Asp Leu 
        195                 200                 205             


Ile Thr Thr Gly Asp Phe Met Ser Arg Phe Cys Ser Asn Leu Cys Leu 
    210                 215                 220                 


Pro Lys Gln Val Gln Met Ala Ala Thr His Ile Ala Arg Lys Ala Val 
225                 230                 235                 240 


Glu Leu Asp Leu Val Pro Gly Arg Ser Pro Ile Ser Val Ala Ala Ala 
                245                 250                 255     


Ala Ile Tyr Met Ala Ser Gln Ala Ser Ala Glu Lys Arg Thr Gln Lys 
            260                 265                 270         


Glu Ile Gly Asp Ile Ala Gly Val Ala Asp Val Thr Ile Arg Gln Ser 
        275                 280                 285             


Tyr Arg Leu Ile Tyr Pro Arg Ala Pro Asp Leu Phe Pro Thr Asp Phe 
    290                 295                 300                 


Lys Phe Asp Thr Pro Val Asp Lys Leu Pro Gln Leu 
305                 310                 315     


<210>  97
<211>  786
<212>  DNA
<213>  Homo sapiens

<400>  97
atggcagcag cgtgtcggag cgtgaagggc ctggtggcgg taataaccgg aggagcctcg       60

ggcctgggcc tggccacggc ggagcgactt gtggggcagg gagcctctgc tgtgcttctg      120

gacctgccca actcgggtgg ggaggcccaa gccaagaagt taggaaacaa ctgcgttttc      180

gccccagccg acgtgacctc tgagaaggat gtgcaaacag ctctggctct agcaaaagga      240

aagtttggcc gtgtggatgt agctgtcaac tgtgcaggca tcgcggtggc tagcaagacg      300

tacaacttaa agaagggcca gacccatacc ttggaagact tccagcgagt tcttgatgtg      360

aatctcatgg gcaccttcaa tgtgatccgc ctggtggctg gtgagatggg ccagaatgaa      420

ccagaccagg gaggccaacg tggggtcatc atcaacactg ccagtgtggc tgccttcgag      480

ggtcaggttg gacaagctgc atactctgct tccaaggggg gaatagtggg catgacactg      540

cccattgctc gggatctggc tcccataggt atccgggtga tgaccattgc cccaggtctg      600

tttggcaccc cactgctgac cagcctccca gagaaagtgt gcaacttctt ggccagccaa      660

gtgcccttcc ctagccgact gggtgaccct gctgagtatg ctcacctcgt acaggccatc      720

atcgagaacc cattcctcaa tggagaggtc atccggctgg atggggccat tcgtatgcag      780

ccttga                                                                 786


<210>  98
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Ala Ala Ala Cys Arg Ser Val Lys Gly Leu Val Ala Val Ile Thr 
1               5                   10                  15      


Gly Gly Ala Ser Gly Leu Gly Leu Ala Thr Ala Glu Arg Leu Val Gly 
            20                  25                  30          


Gln Gly Ala Ser Ala Val Leu Leu Asp Leu Pro Asn Ser Gly Gly Glu 
        35                  40                  45              


Ala Gln Ala Lys Lys Leu Gly Asn Asn Cys Val Phe Ala Pro Ala Asp 
    50                  55                  60                  


Val Thr Ser Glu Lys Asp Val Gln Thr Ala Leu Ala Leu Ala Lys Gly 
65                  70                  75                  80  


Lys Phe Gly Arg Val Asp Val Ala Val Asn Cys Ala Gly Ile Ala Val 
                85                  90                  95      


Ala Ser Lys Thr Tyr Asn Leu Lys Lys Gly Gln Thr His Thr Leu Glu 
            100                 105                 110         


Asp Phe Gln Arg Val Leu Asp Val Asn Leu Met Gly Thr Phe Asn Val 
        115                 120                 125             


Ile Arg Leu Val Ala Gly Glu Met Gly Gln Asn Glu Pro Asp Gln Gly 
    130                 135                 140                 


Gly Gln Arg Gly Val Ile Ile Asn Thr Ala Ser Val Ala Ala Phe Glu 
145                 150                 155                 160 


Gly Gln Val Gly Gln Ala Ala Tyr Ser Ala Ser Lys Gly Gly Ile Val 
                165                 170                 175     


Gly Met Thr Leu Pro Ile Ala Arg Asp Leu Ala Pro Ile Gly Ile Arg 
            180                 185                 190         


Val Met Thr Ile Ala Pro Gly Leu Phe Gly Thr Pro Leu Leu Thr Ser 
        195                 200                 205             


Leu Pro Glu Lys Val Cys Asn Phe Leu Ala Ser Gln Val Pro Phe Pro 
    210                 215                 220                 


Ser Arg Leu Gly Asp Pro Ala Glu Tyr Ala His Leu Val Gln Ala Ile 
225                 230                 235                 240 


Ile Glu Asn Pro Phe Leu Asn Gly Glu Val Ile Arg Leu Asp Gly Ala 
                245                 250                 255     


Ile Arg Met Gln Pro 
            260     


<210>  99
<211>  840
<212>  DNA
<213>  Homo sapiens

<400>  99
atgagcctct ttgatctctt ccggggcttt ttcggctttc ctggacctcg gagccacaga       60

gatccctttt ttggagggat gactcgagat gaagatgatg atgaggaaga agaagaagaa      120

gggggctcat ggggccgtgg gaacccaagg ttccatagtc ctcagcaccc ccctgaggaa      180

tttggcttcg gcttcagctt cagcccagga ggagggatac gtttccacga taacttcggc      240

tttgatgacc tagtacgaga tttcaatagc atcttcagcg atatgggggc ctggaccttg      300

ccttcccatc ctcctgaact tccaggtcct gagtcagaga cacctggtga gagactacgg      360

gagggacaga cacttcggga ctcaatgctt aagtatccag atagtcacca gcccaggatc      420

tttggggggg tcttggagag tgatgcaaga agtgaatccc cccaaccagc accagactgg      480

ggctcccaga ggccatttca taggtttgat gatgtatggc ctatggaccc ccatcctaga      540

accagagagg acaatgatct tgattcccag gtttcccagg agggtcttgg cccggttcta      600

cagccccagc ccaaatccta tttcaagagc atctctgtga ccaagatcac taaaccagat      660

gggatagtgg aggagcgccg gactgtggtg gacagtgagg gccggacaga gactacagta      720

acccgacacg aagcagatag cagtcctagg ggtgatccag aatcaccaag acctccagcc      780

ctggatgatg ccttttccat cctggactta ttcctgggac gttggttccg gtcccggtag      840


<210>  100
<211>  279
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Ser Leu Phe Asp Leu Phe Arg Gly Phe Phe Gly Phe Pro Gly Pro 
1               5                   10                  15      


Arg Ser His Arg Asp Pro Phe Phe Gly Gly Met Thr Arg Asp Glu Asp 
            20                  25                  30          


Asp Asp Glu Glu Glu Glu Glu Glu Gly Gly Ser Trp Gly Arg Gly Asn 
        35                  40                  45              


Pro Arg Phe His Ser Pro Gln His Pro Pro Glu Glu Phe Gly Phe Gly 
    50                  55                  60                  


Phe Ser Phe Ser Pro Gly Gly Gly Ile Arg Phe His Asp Asn Phe Gly 
65                  70                  75                  80  


Phe Asp Asp Leu Val Arg Asp Phe Asn Ser Ile Phe Ser Asp Met Gly 
                85                  90                  95      


Ala Trp Thr Leu Pro Ser His Pro Pro Glu Leu Pro Gly Pro Glu Ser 
            100                 105                 110         


Glu Thr Pro Gly Glu Arg Leu Arg Glu Gly Gln Thr Leu Arg Asp Ser 
        115                 120                 125             


Met Leu Lys Tyr Pro Asp Ser His Gln Pro Arg Ile Phe Gly Gly Val 
    130                 135                 140                 


Leu Glu Ser Asp Ala Arg Ser Glu Ser Pro Gln Pro Ala Pro Asp Trp 
145                 150                 155                 160 


Gly Ser Gln Arg Pro Phe His Arg Phe Asp Asp Val Trp Pro Met Asp 
                165                 170                 175     


Pro His Pro Arg Thr Arg Glu Asp Asn Asp Leu Asp Ser Gln Val Ser 
            180                 185                 190         


Gln Glu Gly Leu Gly Pro Val Leu Gln Pro Gln Pro Lys Ser Tyr Phe 
        195                 200                 205             


Lys Ser Ile Ser Val Thr Lys Ile Thr Lys Pro Asp Gly Ile Val Glu 
    210                 215                 220                 


Glu Arg Arg Thr Val Val Asp Ser Glu Gly Arg Thr Glu Thr Thr Val 
225                 230                 235                 240 


Thr Arg His Glu Ala Asp Ser Ser Pro Arg Gly Asp Pro Glu Ser Pro 
                245                 250                 255     


Arg Pro Pro Ala Leu Asp Asp Ala Phe Ser Ile Leu Asp Leu Phe Leu 
            260                 265                 270         


Gly Arg Trp Phe Arg Ser Arg 
        275                 


<210>  101
<211>  1722
<212>  DNA
<213>  Homo sapiens

<400>  101
atgcttcggt tacccacagt ctttcgccag atgagaccgg tgtccagggt actggctcct       60

catctcactc gggcttatgc caaagatgta aaatttggtg cagatgcccg agccttaatg      120

cttcaaggtg tagacctttt agccgatgct gtggccgtta caatggggcc aaagggaaga      180

acagtgatta ttgagcagag ttggggaagt cccaaagtaa caaaagatgg tgtgactgtt      240

gcaaagtcaa ttgacttaaa agataaatac aaaaacattg gagctaaact tgttcaagat      300

gttgccaata acacaaatga agaagctggg gatggcacta ccactgctac tgtactggca      360

cgctctatag ccaaggaagg cttcgagaag attagcaaag gtgctaatcc agtggaaatc      420

aggagaggtg tgatgttagc tgttgatgct gtaattgctg aacttaaaaa gcagtctaaa      480

cctgtgacca cccctgaaga aattgcacag gttgctacga tttctgcaaa cggagacaaa      540

gaaattggca atatcatctc tgatgcaatg aaaaaagttg gaagaaaggg tgtcatcaca      600

gtaaaggatg gaaaaacact gaatgatgaa ttagaaatta ttgaaggcat gaagtttgat      660

cgaggctata tttctccata ctttattaat acatcaaaag gtcagaaatg tgaattccag      720

gatgcctatg ttctgttgag tgaaaagaaa atttctagta tccagtccat tgtacctgct      780

cttgaaattg ccaatgctca ccgtaagcct ttggtcataa tcgctgaaga tgttgatgga      840

gaagctctaa gtacactcgt cttgaatagg ctaaaggttg gtcttcaggt tgtggcagtc      900

aaggctccag ggtttggtga caatagaaag aaccagctta aagatatggc tattgctact      960

ggtggtgcag tgtttggaga agagggattg accctgaatc ttgaagacgt tcagcctcat     1020

gacttaggaa aagttggaga ggtcattgtg accaaagacg atgccatgct cttaaaagga     1080

aaaggtgaca aggctcaaat tgaaaaacgt attcaagaaa tcattgagca gttagatgtc     1140

acaactagtg aatatgaaaa ggaaaaactg aatgaacggc ttgcaaaact ttcagatgga     1200

gtggctgtgc tgaaggttgg tgggacaagt gatgttgaag tgaatgaaaa gaaagacaga     1260

gttacagatg cccttaatgc tacaagagct gctgttgaag aaggcattgt tttgggaggg     1320

ggttgtgccc tccttcgatg cattccagcc ttggactcat tgactccagc taatgaagat     1380

caaaaaattg gtatagaaat tattaaaaga acactcaaaa ttccagcaat gaccattgct     1440

aagaatgcag gtgttgaagg atctttgata gttgagaaaa ttatgcaaag ttcctcagaa     1500

gttggttatg atgctatggc tggagatttt gtgaatatgg tggaaaaagg aatcattgac     1560

ccaacaaagg ttgtgagaac tgctttattg gatgctgctg gtgtggcctc tctgttaact     1620

acagcagaag ttgtagtcac agaaattcct aaagaagaga aggaccctgg aatgggtgca     1680

atgggtggaa tgggaggtgg tatgggaggt ggcatgttct aa                        1722


<210>  102
<211>  573
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Leu Arg Leu Pro Thr Val Phe Arg Gln Met Arg Pro Val Ser Arg 
1               5                   10                  15      


Val Leu Ala Pro His Leu Thr Arg Ala Tyr Ala Lys Asp Val Lys Phe 
            20                  25                  30          


Gly Ala Asp Ala Arg Ala Leu Met Leu Gln Gly Val Asp Leu Leu Ala 
        35                  40                  45              


Asp Ala Val Ala Val Thr Met Gly Pro Lys Gly Arg Thr Val Ile Ile 
    50                  55                  60                  


Glu Gln Ser Trp Gly Ser Pro Lys Val Thr Lys Asp Gly Val Thr Val 
65                  70                  75                  80  


Ala Lys Ser Ile Asp Leu Lys Asp Lys Tyr Lys Asn Ile Gly Ala Lys 
                85                  90                  95      


Leu Val Gln Asp Val Ala Asn Asn Thr Asn Glu Glu Ala Gly Asp Gly 
            100                 105                 110         


Thr Thr Thr Ala Thr Val Leu Ala Arg Ser Ile Ala Lys Glu Gly Phe 
        115                 120                 125             


Glu Lys Ile Ser Lys Gly Ala Asn Pro Val Glu Ile Arg Arg Gly Val 
    130                 135                 140                 


Met Leu Ala Val Asp Ala Val Ile Ala Glu Leu Lys Lys Gln Ser Lys 
145                 150                 155                 160 


Pro Val Thr Thr Pro Glu Glu Ile Ala Gln Val Ala Thr Ile Ser Ala 
                165                 170                 175     


Asn Gly Asp Lys Glu Ile Gly Asn Ile Ile Ser Asp Ala Met Lys Lys 
            180                 185                 190         


Val Gly Arg Lys Gly Val Ile Thr Val Lys Asp Gly Lys Thr Leu Asn 
        195                 200                 205             


Asp Glu Leu Glu Ile Ile Glu Gly Met Lys Phe Asp Arg Gly Tyr Ile 
    210                 215                 220                 


Ser Pro Tyr Phe Ile Asn Thr Ser Lys Gly Gln Lys Cys Glu Phe Gln 
225                 230                 235                 240 


Asp Ala Tyr Val Leu Leu Ser Glu Lys Lys Ile Ser Ser Ile Gln Ser 
                245                 250                 255     


Ile Val Pro Ala Leu Glu Ile Ala Asn Ala His Arg Lys Pro Leu Val 
            260                 265                 270         


Ile Ile Ala Glu Asp Val Asp Gly Glu Ala Leu Ser Thr Leu Val Leu 
        275                 280                 285             


Asn Arg Leu Lys Val Gly Leu Gln Val Val Ala Val Lys Ala Pro Gly 
    290                 295                 300                 


Phe Gly Asp Asn Arg Lys Asn Gln Leu Lys Asp Met Ala Ile Ala Thr 
305                 310                 315                 320 


Gly Gly Ala Val Phe Gly Glu Glu Gly Leu Thr Leu Asn Leu Glu Asp 
                325                 330                 335     


Val Gln Pro His Asp Leu Gly Lys Val Gly Glu Val Ile Val Thr Lys 
            340                 345                 350         


Asp Asp Ala Met Leu Leu Lys Gly Lys Gly Asp Lys Ala Gln Ile Glu 
        355                 360                 365             


Lys Arg Ile Gln Glu Ile Ile Glu Gln Leu Asp Val Thr Thr Ser Glu 
    370                 375                 380                 


Tyr Glu Lys Glu Lys Leu Asn Glu Arg Leu Ala Lys Leu Ser Asp Gly 
385                 390                 395                 400 


Val Ala Val Leu Lys Val Gly Gly Thr Ser Asp Val Glu Val Asn Glu 
                405                 410                 415     


Lys Lys Asp Arg Val Thr Asp Ala Leu Asn Ala Thr Arg Ala Ala Val 
            420                 425                 430         


Glu Glu Gly Ile Val Leu Gly Gly Gly Cys Ala Leu Leu Arg Cys Ile 
        435                 440                 445             


Pro Ala Leu Asp Ser Leu Thr Pro Ala Asn Glu Asp Gln Lys Ile Gly 
    450                 455                 460                 


Ile Glu Ile Ile Lys Arg Thr Leu Lys Ile Pro Ala Met Thr Ile Ala 
465                 470                 475                 480 


Lys Asn Ala Gly Val Glu Gly Ser Leu Ile Val Glu Lys Ile Met Gln 
                485                 490                 495     


Ser Ser Ser Glu Val Gly Tyr Asp Ala Met Ala Gly Asp Phe Val Asn 
            500                 505                 510         


Met Val Glu Lys Gly Ile Ile Asp Pro Thr Lys Val Val Arg Thr Ala 
        515                 520                 525             


Leu Leu Asp Ala Ala Gly Val Ala Ser Leu Leu Thr Thr Ala Glu Val 
    530                 535                 540                 


Val Val Thr Glu Ile Pro Lys Glu Glu Lys Asp Pro Gly Met Gly Ala 
545                 550                 555                 560 


Met Gly Gly Met Gly Gly Gly Met Gly Gly Gly Met Phe 
                565                 570             


<210>  103
<211>  2139
<212>  DNA
<213>  Homo sapiens

<400>  103
atggccgggg ggccgggccc gggggagccc gcagcccccg gcgcccagca cttcttgtac       60

gaggtgccgc cctgggtcat gtgccgcttc tacaaagtga tggacgccct ggagcccgcc      120

gactggtgcc agttcgccgc cctgatcgtg cgcgaccaga ccgagctgcg gctgtgcgag      180

cgctccgggc agcgcacggc cagcgtcctg tggccctgga tcaaccgcaa cgcccgtgtg      240

gccgacctcg tgcacatcct cacgcacctg cagctgctcc gtgcgcggga catcatcaca      300

gcctggcacc ctcccgcccc gcttccgtcc ccaggcacca ctgccccgag gcccagcagc      360

atccctgcac ccgccgaggc cgaggcctgg agcccccgga agttgccatc ctcagcctcc      420

accttcctct ccccagcttt tccaggctcc cagacccatt cagggcctga gctcggcctg      480

gtcccaagcc ctgcttccct gtggcctcca ccgccatctc cagccccttc ttctaccaag      540

ccaggcccag agagctcagt gtccctcctg cagggagccc gcccctttcc gttttgctgg      600

cccctctgtg agatttcccg gggcacccac aacttctcgg aggagctcaa gatcggggag      660

ggtggctttg ggtgcgtgta ccgggcggtg atgaggaaca cggtgtatgc tgtgaagagg      720

ctgaaggaga acgctgacct ggagtggact gcagtgaagc agagcttcct gaccgaggtg      780

gagcagctgt ccaggtttcg tcacccaaac attgtggact ttgctggcta ctgtgctcag      840

aacggcttct actgcctggt gtacggcttc ctgcccaacg gctccctgga ggaccgtctc      900

cactgccaga cccaggcctg cccacctctc tcctggcctc agcgactgga catccttctg      960

ggtacagccc gggcaattca gtttctacat caggacagcc ccagcctcat ccatggagac     1020

atcaagagtt ccaacgtcct tctggatgag aggctgacac ccaagctggg agactttggc     1080

ctggcccggt tcagccgctt tgccgggtcc agccccagcc agagcagcat ggtggcccgg     1140

acacagacag tgcggggcac cctggcctac ctgcccgagg agtacatcaa gacgggaagg     1200

ctggctgtgg acacggacac cttcagcttt ggggtggtag tgctagagac cttggctggt     1260

cagagggctg tgaagacgca cggtgccagg accaagtatc tgaaagacct ggtggaagag     1320

gaggctgagg aggctggagt ggctttgaga agcacccaga gcacactgca agcaggtctg     1380

gctgcagatg cctgggctgc tcccatcgcc atgcagatct acaagaagca cctggacccc     1440

aggcccgggc cctgcccacc tgagctgggc ctgggcctgg gccagctggc ctgctgctgc     1500

ctgcaccgcc gggccaaaag gaggcctcct atgacccagg tgtacgagag gctagagaag     1560

ctgcaggcag tggtggcggg ggtgcccggg cattcggagg ccgccagctg catcccccct     1620

tccccgcagg agaactccta cgtgtccagc actggcagag cccacagtgg ggctgctcca     1680

tggcagcccc tggcagcgcc atcaggagcc agtgcccagg cagcagagca gctgcagaga     1740

ggccccaacc agcccgtgga gagtgacgag agcctaggcg gcctctctgc tgccctgcgc     1800

tcctggcact tgactccaag ctgccctctg gacccagcac ccctcaggga ggccggctgt     1860

cctcaggggg acacggcagg agaatcgagc tgggggagtg gcccaggatc ccggcccaca     1920

gccgtggaag gactggccct tggcagctct gcatcatcgt cgtcagagcc accgcagatt     1980

atcatcaacc ctgcccgaca gaagatggtc cagaagctgg ccctgtacga ggatggggcc     2040

ctggacagcc tgcagctgct gtcgtccagc tccctcccag gcttgggcct ggaacaggac     2100

aggcaggggc ccgaagaaag tgatgaattt cagagctga                            2139


<210>  104
<211>  712
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Ala Gly Gly Pro Gly Pro Gly Glu Pro Ala Ala Pro Gly Ala Gln 
1               5                   10                  15      


His Phe Leu Tyr Glu Val Pro Pro Trp Val Met Cys Arg Phe Tyr Lys 
            20                  25                  30          


Val Met Asp Ala Leu Glu Pro Ala Asp Trp Cys Gln Phe Ala Ala Leu 
        35                  40                  45              


Ile Val Arg Asp Gln Thr Glu Leu Arg Leu Cys Glu Arg Ser Gly Gln 
    50                  55                  60                  


Arg Thr Ala Ser Val Leu Trp Pro Trp Ile Asn Arg Asn Ala Arg Val 
65                  70                  75                  80  


Ala Asp Leu Val His Ile Leu Thr His Leu Gln Leu Leu Arg Ala Arg 
                85                  90                  95      


Asp Ile Ile Thr Ala Trp His Pro Pro Ala Pro Leu Pro Ser Pro Gly 
            100                 105                 110         


Thr Thr Ala Pro Arg Pro Ser Ser Ile Pro Ala Pro Ala Glu Ala Glu 
        115                 120                 125             


Ala Trp Ser Pro Arg Lys Leu Pro Ser Ser Ala Ser Thr Phe Leu Ser 
    130                 135                 140                 


Pro Ala Phe Pro Gly Ser Gln Thr His Ser Gly Pro Glu Leu Gly Leu 
145                 150                 155                 160 


Val Pro Ser Pro Ala Ser Leu Trp Pro Pro Pro Pro Ser Pro Ala Pro 
                165                 170                 175     


Ser Ser Thr Lys Pro Gly Pro Glu Ser Ser Val Ser Leu Leu Gln Gly 
            180                 185                 190         


Ala Arg Pro Phe Pro Phe Cys Trp Pro Leu Cys Glu Ile Ser Arg Gly 
        195                 200                 205             


Thr His Asn Phe Ser Glu Glu Leu Lys Ile Gly Glu Gly Gly Phe Gly 
    210                 215                 220                 


Cys Val Tyr Arg Ala Val Met Arg Asn Thr Val Tyr Ala Val Lys Arg 
225                 230                 235                 240 


Leu Lys Glu Asn Ala Asp Leu Glu Trp Thr Ala Val Lys Gln Ser Phe 
                245                 250                 255     


Leu Thr Glu Val Glu Gln Leu Ser Arg Phe Arg His Pro Asn Ile Val 
            260                 265                 270         


Asp Phe Ala Gly Tyr Cys Ala Gln Asn Gly Phe Tyr Cys Leu Val Tyr 
        275                 280                 285             


Gly Phe Leu Pro Asn Gly Ser Leu Glu Asp Arg Leu His Cys Gln Thr 
    290                 295                 300                 


Gln Ala Cys Pro Pro Leu Ser Trp Pro Gln Arg Leu Asp Ile Leu Leu 
305                 310                 315                 320 


Gly Thr Ala Arg Ala Ile Gln Phe Leu His Gln Asp Ser Pro Ser Leu 
                325                 330                 335     


Ile His Gly Asp Ile Lys Ser Ser Asn Val Leu Leu Asp Glu Arg Leu 
            340                 345                 350         


Thr Pro Lys Leu Gly Asp Phe Gly Leu Ala Arg Phe Ser Arg Phe Ala 
        355                 360                 365             


Gly Ser Ser Pro Ser Gln Ser Ser Met Val Ala Arg Thr Gln Thr Val 
    370                 375                 380                 


Arg Gly Thr Leu Ala Tyr Leu Pro Glu Glu Tyr Ile Lys Thr Gly Arg 
385                 390                 395                 400 


Leu Ala Val Asp Thr Asp Thr Phe Ser Phe Gly Val Val Val Leu Glu 
                405                 410                 415     


Thr Leu Ala Gly Gln Arg Ala Val Lys Thr His Gly Ala Arg Thr Lys 
            420                 425                 430         


Tyr Leu Lys Asp Leu Val Glu Glu Glu Ala Glu Glu Ala Gly Val Ala 
        435                 440                 445             


Leu Arg Ser Thr Gln Ser Thr Leu Gln Ala Gly Leu Ala Ala Asp Ala 
    450                 455                 460                 


Trp Ala Ala Pro Ile Ala Met Gln Ile Tyr Lys Lys His Leu Asp Pro 
465                 470                 475                 480 


Arg Pro Gly Pro Cys Pro Pro Glu Leu Gly Leu Gly Leu Gly Gln Leu 
                485                 490                 495     


Ala Cys Cys Cys Leu His Arg Arg Ala Lys Arg Arg Pro Pro Met Thr 
            500                 505                 510         


Gln Val Tyr Glu Arg Leu Glu Lys Leu Gln Ala Val Val Ala Gly Val 
        515                 520                 525             


Pro Gly His Ser Glu Ala Ala Ser Cys Ile Pro Pro Ser Pro Gln Glu 
    530                 535                 540                 


Asn Ser Tyr Val Ser Ser Thr Gly Arg Ala His Ser Gly Ala Ala Pro 
545                 550                 555                 560 


Trp Gln Pro Leu Ala Ala Pro Ser Gly Ala Ser Ala Gln Ala Ala Glu 
                565                 570                 575     


Gln Leu Gln Arg Gly Pro Asn Gln Pro Val Glu Ser Asp Glu Ser Leu 
            580                 585                 590         


Gly Gly Leu Ser Ala Ala Leu Arg Ser Trp His Leu Thr Pro Ser Cys 
        595                 600                 605             


Pro Leu Asp Pro Ala Pro Leu Arg Glu Ala Gly Cys Pro Gln Gly Asp 
    610                 615                 620                 


Thr Ala Gly Glu Ser Ser Trp Gly Ser Gly Pro Gly Ser Arg Pro Thr 
625                 630                 635                 640 


Ala Val Glu Gly Leu Ala Leu Gly Ser Ser Ala Ser Ser Ser Ser Glu 
                645                 650                 655     


Pro Pro Gln Ile Ile Ile Asn Pro Ala Arg Gln Lys Met Val Gln Lys 
            660                 665                 670         


Leu Ala Leu Tyr Glu Asp Gly Ala Leu Asp Ser Leu Gln Leu Leu Ser 
        675                 680                 685             


Ser Ser Ser Leu Pro Gly Leu Gly Leu Glu Gln Asp Arg Gln Gly Pro 
    690                 695                 700                 


Glu Glu Ser Asp Glu Phe Gln Ser 
705                 710         


<210>  105
<211>  3150
<212>  DNA
<213>  Homo sapiens

<400>  105
atggggagcc ggacgccaga gtcccctctc cacgccgtgc agctgcgctg gggcccccgg       60

cgccgacccc cgctgctgcc gctgctgttg ctgctgctgc cgccgccacc cagggtcggg      120

ggcttcaact tagacgcgga ggccccagca gtactctcgg ggcccccggg ctccttcttc      180

ggattctcag tggagtttta ccggccggga acagacgggg tcagtgtgct ggtgggagca      240

cccaaggcta ataccagcca gccaggagtg ctgcagggtg gtgctgtcta cctctgtcct      300

tggggtgcca gccccacaca gtgcaccccc attgaatttg acagcaaagg ctctcggctc      360

ctggagtcct cactgtccag ctcagaggga gaggagcctg tggagtacaa gtccttgcag      420

tggttcgggg caacagttcg agcccatggc tcctccatct tggcatgcgc tccactgtac      480

agctggcgca cagagaagga gccactgagc gaccccgtgg gcacctgcta cctctccaca      540

gataacttca cccgaattct ggagtatgca ccctgccgct cagatttcag ctgggcagca      600

ggacagggtt actgccaagg aggcttcagt gccgagttca ccaagactgg ccgtgtggtt      660

ttaggtggac caggaagcta tttctggcaa ggccagatcc tgtctgccac tcaggagcag      720

attgcagaat cttattaccc cgagtacctg atcaacctgg ttcaggggca gctgcagact      780

cgccaggcca gttccatcta tgatgacagc tacctaggat actctgtggc tgttggtgaa      840

ttcagtggtg atgacacaga agactttgtt gctggtgtgc ccaaagggaa cctcacttac      900

ggctatgtca ccatccttaa tggctcagac attcgatccc tctacaactt ctcaggggaa      960

cagatggcct cctactttgg ctatgcagtg gccgccacag acgtcaatgg ggatgggctg     1020

gatgacttgc tggtgggggc acccctgctc atggatcgga cccctgacgg gcggcctcag     1080

gaggtgggca gggtctacgt ctacctgcag cacccagccg gcatagagcc cacgcccacc     1140

cttaccctca ctggccatga tgagtttggc cgatttggca gctccttgac ccccctgggg     1200

gacctggacc aggatggcta caatgatgtg gccatcgggg ctccctttgg tggggagacc     1260

cagcagggag tagtgtttgt atttcctggg ggcccaggag ggctgggctc taagccttcc     1320

caggttctgc agcccctgtg ggcagccagc cacaccccag acttctttgg ctctgccctt     1380

cgaggaggcc gagacctgga tggcaatgga tatcctgatc tgattgtggg gtcctttggt     1440

gtggacaagg ctgtggtata caggggccgc cccatcgtgt ccgctagtgc ctccctcacc     1500

atcttccccg ccatgttcaa cccagaggag cggagctgca gcttagaggg gaaccctgtg     1560

gcctgcatca accttagctt ctgcctcaat gcttctggaa aacacgttgc tgactccatt     1620

ggtttcacag tggaacttca gctggactgg cagaagcaga agggaggggt acggcgggca     1680

ctgttcctgg cctccaggca ggcaaccctg acccagaccc tgctcatcca gaatggggct     1740

cgagaggatt gcagagagat gaagatctac ctcaggaacg agtcagaatt tcgagacaaa     1800

ctctcgccga ttcacatcgc tctcaacttc tccttggacc cccaagcccc agtggacagc     1860

cacggcctca ggccagccct acattatcag agcaagagcc ggatagagga caaggctcag     1920

atcttgctgg actgtggaga agacaacatc tgtgtgcctg acctgcagct ggaagtgttt     1980

ggggagcaga accatgtgta cctgggtgac aagaatgccc tgaacctcac tttccatgcc     2040

cagaatgtgg gtgagggtgg cgcctatgag gctgagcttc gggtcaccgc ccctccagag     2100

gctgagtact caggactcgt cagacaccca gggaacttct ccagcctgag ctgtgactac     2160

tttgccgtga accagagccg cctgctggtg tgtgacctgg gcaaccccat gaaggcagga     2220

gccagtctgt ggggtggcct tcggtttaca gtccctcatc tccgggacac taagaaaacc     2280

atccagtttg acttccagat cctcagcaag aatctcaaca actcgcaaag cgacgtggtt     2340

tcctttcggc tctccgtgga ggctcaggcc caggtcaccc tgaacggtgt ctccaagcct     2400

gaggcagtgc tattcccagt aagcgactgg catccccgag accagcctca gaaggaggag     2460

gacctgggac ctgctgtcca ccatgtctat gagctcatca accaaggccc cagctccatt     2520

agccagggtg tgctggaact cagctgtccc caggctctgg aaggtcagca gctcctatat     2580

gtgaccagag ttacgggact caactgcacc accaatcacc ccattaaccc aaagggcctg     2640

gagttggatc ccgagggttc cctgcaccac cagcaaaaac gggaagctcc aagccgcagc     2700

tctgcttcct cgggacctca gatcctgaaa tgcccggagg ctgagtgttt caggctgcgc     2760

tgtgagctcg ggcccctgca ccaacaagag agccaaagtc tgcagttgca tttccgagtc     2820

tgggccaaga ctttcttgca gcgggagcac cagccattta gcctgcagtg tgaggctgtg     2880

tacaaagccc tgaagatgcc ctaccgaatc ctgcctcggc agctgcccca aaaagagcgt     2940

caggtggcca cagctgtgca atggaccaag gcagaaggca gctatggcgt cccactgtgg     3000

atcatcatcc tagccatcct gtttggcctc ctgctcctag gtctactcat ctacatcctc     3060

tacaagcttg gattcttcaa acgctccctc ccatatggca ccgccatgga aaaagctcag     3120

ctcaagcctc cagccacctc tgatgcctga                                      3150


<210>  106
<211>  1049
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Gly Ser Arg Thr Pro Glu Ser Pro Leu His Ala Val Gln Leu Arg 
1               5                   10                  15      


Trp Gly Pro Arg Arg Arg Pro Pro Leu Leu Pro Leu Leu Leu Leu Leu 
            20                  25                  30          


Leu Pro Pro Pro Pro Arg Val Gly Gly Phe Asn Leu Asp Ala Glu Ala 
        35                  40                  45              


Pro Ala Val Leu Ser Gly Pro Pro Gly Ser Phe Phe Gly Phe Ser Val 
    50                  55                  60                  


Glu Phe Tyr Arg Pro Gly Thr Asp Gly Val Ser Val Leu Val Gly Ala 
65                  70                  75                  80  


Pro Lys Ala Asn Thr Ser Gln Pro Gly Val Leu Gln Gly Gly Ala Val 
                85                  90                  95      


Tyr Leu Cys Pro Trp Gly Ala Ser Pro Thr Gln Cys Thr Pro Ile Glu 
            100                 105                 110         


Phe Asp Ser Lys Gly Ser Arg Leu Leu Glu Ser Ser Leu Ser Ser Ser 
        115                 120                 125             


Glu Gly Glu Glu Pro Val Glu Tyr Lys Ser Leu Gln Trp Phe Gly Ala 
    130                 135                 140                 


Thr Val Arg Ala His Gly Ser Ser Ile Leu Ala Cys Ala Pro Leu Tyr 
145                 150                 155                 160 


Ser Trp Arg Thr Glu Lys Glu Pro Leu Ser Asp Pro Val Gly Thr Cys 
                165                 170                 175     


Tyr Leu Ser Thr Asp Asn Phe Thr Arg Ile Leu Glu Tyr Ala Pro Cys 
            180                 185                 190         


Arg Ser Asp Phe Ser Trp Ala Ala Gly Gln Gly Tyr Cys Gln Gly Gly 
        195                 200                 205             


Phe Ser Ala Glu Phe Thr Lys Thr Gly Arg Val Val Leu Gly Gly Pro 
    210                 215                 220                 


Gly Ser Tyr Phe Trp Gln Gly Gln Ile Leu Ser Ala Thr Gln Glu Gln 
225                 230                 235                 240 


Ile Ala Glu Ser Tyr Tyr Pro Glu Tyr Leu Ile Asn Leu Val Gln Gly 
                245                 250                 255     


Gln Leu Gln Thr Arg Gln Ala Ser Ser Ile Tyr Asp Asp Ser Tyr Leu 
            260                 265                 270         


Gly Tyr Ser Val Ala Val Gly Glu Phe Ser Gly Asp Asp Thr Glu Asp 
        275                 280                 285             


Phe Val Ala Gly Val Pro Lys Gly Asn Leu Thr Tyr Gly Tyr Val Thr 
    290                 295                 300                 


Ile Leu Asn Gly Ser Asp Ile Arg Ser Leu Tyr Asn Phe Ser Gly Glu 
305                 310                 315                 320 


Gln Met Ala Ser Tyr Phe Gly Tyr Ala Val Ala Ala Thr Asp Val Asn 
                325                 330                 335     


Gly Asp Gly Leu Asp Asp Leu Leu Val Gly Ala Pro Leu Leu Met Asp 
            340                 345                 350         


Arg Thr Pro Asp Gly Arg Pro Gln Glu Val Gly Arg Val Tyr Val Tyr 
        355                 360                 365             


Leu Gln His Pro Ala Gly Ile Glu Pro Thr Pro Thr Leu Thr Leu Thr 
    370                 375                 380                 


Gly His Asp Glu Phe Gly Arg Phe Gly Ser Ser Leu Thr Pro Leu Gly 
385                 390                 395                 400 


Asp Leu Asp Gln Asp Gly Tyr Asn Asp Val Ala Ile Gly Ala Pro Phe 
                405                 410                 415     


Gly Gly Glu Thr Gln Gln Gly Val Val Phe Val Phe Pro Gly Gly Pro 
            420                 425                 430         


Gly Gly Leu Gly Ser Lys Pro Ser Gln Val Leu Gln Pro Leu Trp Ala 
        435                 440                 445             


Ala Ser His Thr Pro Asp Phe Phe Gly Ser Ala Leu Arg Gly Gly Arg 
    450                 455                 460                 


Asp Leu Asp Gly Asn Gly Tyr Pro Asp Leu Ile Val Gly Ser Phe Gly 
465                 470                 475                 480 


Val Asp Lys Ala Val Val Tyr Arg Gly Arg Pro Ile Val Ser Ala Ser 
                485                 490                 495     


Ala Ser Leu Thr Ile Phe Pro Ala Met Phe Asn Pro Glu Glu Arg Ser 
            500                 505                 510         


Cys Ser Leu Glu Gly Asn Pro Val Ala Cys Ile Asn Leu Ser Phe Cys 
        515                 520                 525             


Leu Asn Ala Ser Gly Lys His Val Ala Asp Ser Ile Gly Phe Thr Val 
    530                 535                 540                 


Glu Leu Gln Leu Asp Trp Gln Lys Gln Lys Gly Gly Val Arg Arg Ala 
545                 550                 555                 560 


Leu Phe Leu Ala Ser Arg Gln Ala Thr Leu Thr Gln Thr Leu Leu Ile 
                565                 570                 575     


Gln Asn Gly Ala Arg Glu Asp Cys Arg Glu Met Lys Ile Tyr Leu Arg 
            580                 585                 590         


Asn Glu Ser Glu Phe Arg Asp Lys Leu Ser Pro Ile His Ile Ala Leu 
        595                 600                 605             


Asn Phe Ser Leu Asp Pro Gln Ala Pro Val Asp Ser His Gly Leu Arg 
    610                 615                 620                 


Pro Ala Leu His Tyr Gln Ser Lys Ser Arg Ile Glu Asp Lys Ala Gln 
625                 630                 635                 640 


Ile Leu Leu Asp Cys Gly Glu Asp Asn Ile Cys Val Pro Asp Leu Gln 
                645                 650                 655     


Leu Glu Val Phe Gly Glu Gln Asn His Val Tyr Leu Gly Asp Lys Asn 
            660                 665                 670         


Ala Leu Asn Leu Thr Phe His Ala Gln Asn Val Gly Glu Gly Gly Ala 
        675                 680                 685             


Tyr Glu Ala Glu Leu Arg Val Thr Ala Pro Pro Glu Ala Glu Tyr Ser 
    690                 695                 700                 


Gly Leu Val Arg His Pro Gly Asn Phe Ser Ser Leu Ser Cys Asp Tyr 
705                 710                 715                 720 


Phe Ala Val Asn Gln Ser Arg Leu Leu Val Cys Asp Leu Gly Asn Pro 
                725                 730                 735     


Met Lys Ala Gly Ala Ser Leu Trp Gly Gly Leu Arg Phe Thr Val Pro 
            740                 745                 750         


His Leu Arg Asp Thr Lys Lys Thr Ile Gln Phe Asp Phe Gln Ile Leu 
        755                 760                 765             


Ser Lys Asn Leu Asn Asn Ser Gln Ser Asp Val Val Ser Phe Arg Leu 
    770                 775                 780                 


Ser Val Glu Ala Gln Ala Gln Val Thr Leu Asn Gly Val Ser Lys Pro 
785                 790                 795                 800 


Glu Ala Val Leu Phe Pro Val Ser Asp Trp His Pro Arg Asp Gln Pro 
                805                 810                 815     


Gln Lys Glu Glu Asp Leu Gly Pro Ala Val His His Val Tyr Glu Leu 
            820                 825                 830         


Ile Asn Gln Gly Pro Ser Ser Ile Ser Gln Gly Val Leu Glu Leu Ser 
        835                 840                 845             


Cys Pro Gln Ala Leu Glu Gly Gln Gln Leu Leu Tyr Val Thr Arg Val 
    850                 855                 860                 


Thr Gly Leu Asn Cys Thr Thr Asn His Pro Ile Asn Pro Lys Gly Leu 
865                 870                 875                 880 


Glu Leu Asp Pro Glu Gly Ser Leu His His Gln Gln Lys Arg Glu Ala 
                885                 890                 895     


Pro Ser Arg Ser Ser Ala Ser Ser Gly Pro Gln Ile Leu Lys Cys Pro 
            900                 905                 910         


Glu Ala Glu Cys Phe Arg Leu Arg Cys Glu Leu Gly Pro Leu His Gln 
        915                 920                 925             


Gln Glu Ser Gln Ser Leu Gln Leu His Phe Arg Val Trp Ala Lys Thr 
    930                 935                 940                 


Phe Leu Gln Arg Glu His Gln Pro Phe Ser Leu Gln Cys Glu Ala Val 
945                 950                 955                 960 


Tyr Lys Ala Leu Lys Met Pro Tyr Arg Ile Leu Pro Arg Gln Leu Pro 
                965                 970                 975     


Gln Lys Glu Arg Gln Val Ala Thr Ala Val Gln Trp Thr Lys Ala Glu 
            980                 985                 990         


Gly Ser Tyr Gly Val Pro Leu Trp  Ile Ile Ile Leu Ala  Ile Leu Phe 
        995                 1000                 1005             


Gly Leu  Leu Leu Leu Gly Leu  Leu Ile Tyr Ile Leu  Tyr Lys Leu 
    1010                 1015                 1020             


Gly Phe  Phe Lys Arg Ser Leu  Pro Tyr Gly Thr Ala  Met Glu Lys 
    1025                 1030                 1035             


Ala Gln  Leu Lys Pro Pro Ala  Thr Ser Asp Ala 
    1040                 1045                 


<210>  107
<211>  786
<212>  DNA
<213>  Homo sapiens

<400>  107
atgtgggtcc cggttgtctt cctcaccctg tccgtgacgt ggattggtgc tgcacccctc       60

atcctgtctc ggattgtggg aggctgggag tgcgagaagc attcccaacc ctggcaggtg      120

cttgtggcct ctcgtggcag ggcagtctgc ggcggtgttc tggtgcaccc ccagtgggtc      180

ctcacagctg cccactgcat caggaacaaa agcgtgatct tgctgggtcg gcacagcctg      240

tttcatcctg aagacacagg ccaggtattt caggtcagcc acagcttccc acacccgctc      300

tacgatatga gcctcctgaa gaatcgattc ctcaggccag gtgatgactc cagccacgac      360

ctcatgctgc tccgcctgtc agagcctgcc gagctcacgg atgctgtgaa ggtcatggac      420

ctgcccaccc aggagccagc actggggacc acctgctacg cctcaggctg gggcagcatt      480

gaaccagagg agttcttgac cccaaagaaa cttcagtgtg tggacctcca tgttatttcc      540

aatgacgtgt gtgcgcaagt tcaccctcag aaggtgacca agttcatgct gtgtgctgga      600

cgctggacag ggggcaaaag cacctgctcg ggtgattctg ggggcccact tgtctgtaat      660

ggtgtgcttc aaggtatcac gtcatggggc agtgaaccat gtgccctgcc cgaaaggcct      720

tccctgtaca ccaaggtggt gcattaccgg aagtggatca aggacaccat cgtggccaac      780

ccctga                                                                 786


<210>  108
<211>  261
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Trp Val Pro Val Val Phe Leu Thr Leu Ser Val Thr Trp Ile Gly 
1               5                   10                  15      


Ala Ala Pro Leu Ile Leu Ser Arg Ile Val Gly Gly Trp Glu Cys Glu 
            20                  25                  30          


Lys His Ser Gln Pro Trp Gln Val Leu Val Ala Ser Arg Gly Arg Ala 
        35                  40                  45              


Val Cys Gly Gly Val Leu Val His Pro Gln Trp Val Leu Thr Ala Ala 
    50                  55                  60                  


His Cys Ile Arg Asn Lys Ser Val Ile Leu Leu Gly Arg His Ser Leu 
65                  70                  75                  80  


Phe His Pro Glu Asp Thr Gly Gln Val Phe Gln Val Ser His Ser Phe 
                85                  90                  95      


Pro His Pro Leu Tyr Asp Met Ser Leu Leu Lys Asn Arg Phe Leu Arg 
            100                 105                 110         


Pro Gly Asp Asp Ser Ser His Asp Leu Met Leu Leu Arg Leu Ser Glu 
        115                 120                 125             


Pro Ala Glu Leu Thr Asp Ala Val Lys Val Met Asp Leu Pro Thr Gln 
    130                 135                 140                 


Glu Pro Ala Leu Gly Thr Thr Cys Tyr Ala Ser Gly Trp Gly Ser Ile 
145                 150                 155                 160 


Glu Pro Glu Glu Phe Leu Thr Pro Lys Lys Leu Gln Cys Val Asp Leu 
                165                 170                 175     


His Val Ile Ser Asn Asp Val Cys Ala Gln Val His Pro Gln Lys Val 
            180                 185                 190         


Thr Lys Phe Met Leu Cys Ala Gly Arg Trp Thr Gly Gly Lys Ser Thr 
        195                 200                 205             


Cys Ser Gly Asp Ser Gly Gly Pro Leu Val Cys Asn Gly Val Leu Gln 
    210                 215                 220                 


Gly Ile Thr Ser Trp Gly Ser Glu Pro Cys Ala Leu Pro Glu Arg Pro 
225                 230                 235                 240 


Ser Leu Tyr Thr Lys Val Val His Tyr Arg Lys Trp Ile Lys Asp Thr 
                245                 250                 255     


Ile Val Ala Asn Pro 
            260     


<210>  109
<211>  1590
<212>  DNA
<213>  Homo sapiens

<400>  109
atgtccacca acgagaatgc taatacacca gctgcccgtc ttcacagatt caagaacaag       60

ggaaaagaca gtacagaaat gaggcgtcgc agaatagagg tcaatgtgga gctgaggaaa      120

gctaagaagg atgaccagat gctgaagagg agaaatgtaa gctcatttcc tgatgatgct      180

acttctccgc tgcaggaaaa ccgcaacaac cagggcactg taaattggtc tgttgatgac      240

attgtcaaag gcataaatag cagcaatgtg gaaaatcagc tccaagctac tcaagctgcc      300

aggaaactac tttccagaga aaaacagccc cccatagaca acataatccg ggctggtttg      360

attccgaaat ttgtgtcctt cttgggcaga actgattgta gtcccattca gtttgaatct      420

gcttgggcac tcactaacat tgcttctggg acatcagaac aaaccaaggc tgtggtagat      480

ggaggtgcca tcccagcatt catttctctg ttggcatctc cccatgctca catcagtgaa      540

caagctgtct gggctctagg aaacattgca ggtgatggct cagtgttccg agacttggtt      600

attaagtacg gtgcagttga cccactgttg gctctccttg cagttcctga tatgtcatct      660

ttagcatgtg gctacttacg taatcttacc tggacacttt ctaatctttg ccgcaacaag      720

aatcctgcac ccccgataga tgctgttgag cagattcttc ctaccttagt tcggctcctg      780

catcatgatg atccagaagt attagcagat acctgctggg ctatttccta ccttactgat      840

ggtccaaatg aacgaattgg catggtggtg aaaacaggag ttgtgcccca acttgtgaag      900

cttctaggag cttctgaatt gccaattgtg actcctgccc taagagccat agggaatatt      960

gtcactggta cagatgaaca gactcaggtt gtgattgatg caggagcact cgccgtcttt     1020

cccagcctgc tcaccaaccc caaaactaac attcagaagg aagctacgtg gacaatgtca     1080

aacatcacag ccggccgcca ggaccagata cagcaagttg tgaatcatgg attagtccca     1140

ttccttgtca gtgttctctc taaggcagat tttaagacac aaaaggaagc tgtgtgggcc     1200

gtgaccaact ataccagtgg tggaacagtt gaacagattg tgtaccttgt tcactgtggc     1260

ataatagaac cgttgatgaa cctcttaact gcaaaagata ccaagattat tctggttatc     1320

ctggatgcca tttcaaatat ctttcaggct gctgagaaac taggtgaaac tgagaaactt     1380

agtataatga ttgaagaatg tggaggctta gacaaaattg aagctctaca aaaccatgaa     1440

aatgagtctg tgtataaggc ttcgttaagc ttaattgaga agtatttctc tgtagaggaa     1500

gaggaagatc aaaacgttgt accagaaact acctctgaag gctacacttt ccaagttcag     1560

gatggggctc ctgggacctt taacttttag                                      1590


<210>  110
<211>  529
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Ser Thr Asn Glu Asn Ala Asn Thr Pro Ala Ala Arg Leu His Arg 
1               5                   10                  15      


Phe Lys Asn Lys Gly Lys Asp Ser Thr Glu Met Arg Arg Arg Arg Ile 
            20                  25                  30          


Glu Val Asn Val Glu Leu Arg Lys Ala Lys Lys Asp Asp Gln Met Leu 
        35                  40                  45              


Lys Arg Arg Asn Val Ser Ser Phe Pro Asp Asp Ala Thr Ser Pro Leu 
    50                  55                  60                  


Gln Glu Asn Arg Asn Asn Gln Gly Thr Val Asn Trp Ser Val Asp Asp 
65                  70                  75                  80  


Ile Val Lys Gly Ile Asn Ser Ser Asn Val Glu Asn Gln Leu Gln Ala 
                85                  90                  95      


Thr Gln Ala Ala Arg Lys Leu Leu Ser Arg Glu Lys Gln Pro Pro Ile 
            100                 105                 110         


Asp Asn Ile Ile Arg Ala Gly Leu Ile Pro Lys Phe Val Ser Phe Leu 
        115                 120                 125             


Gly Arg Thr Asp Cys Ser Pro Ile Gln Phe Glu Ser Ala Trp Ala Leu 
    130                 135                 140                 


Thr Asn Ile Ala Ser Gly Thr Ser Glu Gln Thr Lys Ala Val Val Asp 
145                 150                 155                 160 


Gly Gly Ala Ile Pro Ala Phe Ile Ser Leu Leu Ala Ser Pro His Ala 
                165                 170                 175     


His Ile Ser Glu Gln Ala Val Trp Ala Leu Gly Asn Ile Ala Gly Asp 
            180                 185                 190         


Gly Ser Val Phe Arg Asp Leu Val Ile Lys Tyr Gly Ala Val Asp Pro 
        195                 200                 205             


Leu Leu Ala Leu Leu Ala Val Pro Asp Met Ser Ser Leu Ala Cys Gly 
    210                 215                 220                 


Tyr Leu Arg Asn Leu Thr Trp Thr Leu Ser Asn Leu Cys Arg Asn Lys 
225                 230                 235                 240 


Asn Pro Ala Pro Pro Ile Asp Ala Val Glu Gln Ile Leu Pro Thr Leu 
                245                 250                 255     


Val Arg Leu Leu His His Asp Asp Pro Glu Val Leu Ala Asp Thr Cys 
            260                 265                 270         


Trp Ala Ile Ser Tyr Leu Thr Asp Gly Pro Asn Glu Arg Ile Gly Met 
        275                 280                 285             


Val Val Lys Thr Gly Val Val Pro Gln Leu Val Lys Leu Leu Gly Ala 
    290                 295                 300                 


Ser Glu Leu Pro Ile Val Thr Pro Ala Leu Arg Ala Ile Gly Asn Ile 
305                 310                 315                 320 


Val Thr Gly Thr Asp Glu Gln Thr Gln Val Val Ile Asp Ala Gly Ala 
                325                 330                 335     


Leu Ala Val Phe Pro Ser Leu Leu Thr Asn Pro Lys Thr Asn Ile Gln 
            340                 345                 350         


Lys Glu Ala Thr Trp Thr Met Ser Asn Ile Thr Ala Gly Arg Gln Asp 
        355                 360                 365             


Gln Ile Gln Gln Val Val Asn His Gly Leu Val Pro Phe Leu Val Ser 
    370                 375                 380                 


Val Leu Ser Lys Ala Asp Phe Lys Thr Gln Lys Glu Ala Val Trp Ala 
385                 390                 395                 400 


Val Thr Asn Tyr Thr Ser Gly Gly Thr Val Glu Gln Ile Val Tyr Leu 
                405                 410                 415     


Val His Cys Gly Ile Ile Glu Pro Leu Met Asn Leu Leu Thr Ala Lys 
            420                 425                 430         


Asp Thr Lys Ile Ile Leu Val Ile Leu Asp Ala Ile Ser Asn Ile Phe 
        435                 440                 445             


Gln Ala Ala Glu Lys Leu Gly Glu Thr Glu Lys Leu Ser Ile Met Ile 
    450                 455                 460                 


Glu Glu Cys Gly Gly Leu Asp Lys Ile Glu Ala Leu Gln Asn His Glu 
465                 470                 475                 480 


Asn Glu Ser Val Tyr Lys Ala Ser Leu Ser Leu Ile Glu Lys Tyr Phe 
                485                 490                 495     


Ser Val Glu Glu Glu Glu Asp Gln Asn Val Val Pro Glu Thr Thr Ser 
            500                 505                 510         


Glu Gly Tyr Thr Phe Gln Val Gln Asp Gly Ala Pro Gly Thr Phe Asn 
        515                 520                 525             


Phe 
    


<210>  111
<211>  1221
<212>  DNA
<213>  Homo sapiens

<400>  111
atggttcact gtgccggctg caaaaggccc atcctggacc gctttctctt gaacgtgctg       60

gacagggcct ggcacgtcaa gtgcgtccag tgctgtgaat gtaaatgcaa cctgaccgag      120

aagtgcttct ccagggaagg caaactctac tgcaagaacg acttcttccg gtgtttcggt      180

accaaatgcg caggctgcgc tcagggcatc tcccctagcg acctggtgcg gagagcgcgg      240

agcaaagtgt ttcacctgaa ctgcttcacc tgcatgatgt gtaacaagca gctctccact      300

ggcgaggaac tctacatcat cgacgagaat aagttcgtct gcaaagagga ttacctaagt      360

aacagcagtg ttgccaaaga gaacagcctt cactcggcca ccacgggcag tgaccccagt      420

ttgtctccgg attcccaaga cccgtcgcag gacgacgcca aggactcgga gagcgccaac      480

gtgtcggaca aggaagcggg tagcaacgag aatgacgacc agaacctggg cgccaagcgg      540

cggggaccgc gcaccaccat caaagccaag cagctggaga cgctgaaggc cgccttcgct      600

gctacaccca agcccacccg ccacatccgc gagcagctgg cgcaggagac cggcctcaac      660

atgcgcgtca ttcaggtctg gttccagaac cggcgctcca aggagcggag gatgaagcag      720

ctgagcgccc tgggcgcccg gcgccacgcc ttcttccgca gtccgcgccg gatgcggccg      780

ctggtggacc gcctggagcc gggcgagctc atccccaatg gtcccttctc cttctacgga      840

gattaccaga gcgagtacta cgggcccggg ggcaactacg acttcttccc gcaaggcccc      900

ccgtcctcgc aggcccagac accagtggac ctacccttcg tgccgtcatc tgggccgtcc      960

gggacgcccc tgggtggcct ggagcacccg ctgccgggcc accacccgtc gagcgaggcg     1020

cagcggttta ccgacatcct ggcgcaccca cccggggact cgcccagccc cgagcccagc     1080

ctgcccgggc ctctgcactc catgtcggcc gaggtcttcg gacccagccc gcccttctcg     1140

tcgctgtcgg tcaacggtgg ggcgagctac ggaaaccacc tgtcccaccc ccccgaaatg     1200

aacgaggcgg ccgtgtggta g                                               1221


<210>  112
<211>  406
<212>  PRT
<213>  Homo sapiens

<400>  112

Met Val His Cys Ala Gly Cys Lys Arg Pro Ile Leu Asp Arg Phe Leu 
1               5                   10                  15      


Leu Asn Val Leu Asp Arg Ala Trp His Val Lys Cys Val Gln Cys Cys 
            20                  25                  30          


Glu Cys Lys Cys Asn Leu Thr Glu Lys Cys Phe Ser Arg Glu Gly Lys 
        35                  40                  45              


Leu Tyr Cys Lys Asn Asp Phe Phe Arg Cys Phe Gly Thr Lys Cys Ala 
    50                  55                  60                  


Gly Cys Ala Gln Gly Ile Ser Pro Ser Asp Leu Val Arg Arg Ala Arg 
65                  70                  75                  80  


Ser Lys Val Phe His Leu Asn Cys Phe Thr Cys Met Met Cys Asn Lys 
                85                  90                  95      


Gln Leu Ser Thr Gly Glu Glu Leu Tyr Ile Ile Asp Glu Asn Lys Phe 
            100                 105                 110         


Val Cys Lys Glu Asp Tyr Leu Ser Asn Ser Ser Val Ala Lys Glu Asn 
        115                 120                 125             


Ser Leu His Ser Ala Thr Thr Gly Ser Asp Pro Ser Leu Ser Pro Asp 
    130                 135                 140                 


Ser Gln Asp Pro Ser Gln Asp Asp Ala Lys Asp Ser Glu Ser Ala Asn 
145                 150                 155                 160 


Val Ser Asp Lys Glu Ala Gly Ser Asn Glu Asn Asp Asp Gln Asn Leu 
                165                 170                 175     


Gly Ala Lys Arg Arg Gly Pro Arg Thr Thr Ile Lys Ala Lys Gln Leu 
            180                 185                 190         


Glu Thr Leu Lys Ala Ala Phe Ala Ala Thr Pro Lys Pro Thr Arg His 
        195                 200                 205             


Ile Arg Glu Gln Leu Ala Gln Glu Thr Gly Leu Asn Met Arg Val Ile 
    210                 215                 220                 


Gln Val Trp Phe Gln Asn Arg Arg Ser Lys Glu Arg Arg Met Lys Gln 
225                 230                 235                 240 


Leu Ser Ala Leu Gly Ala Arg Arg His Ala Phe Phe Arg Ser Pro Arg 
                245                 250                 255     


Arg Met Arg Pro Leu Val Asp Arg Leu Glu Pro Gly Glu Leu Ile Pro 
            260                 265                 270         


Asn Gly Pro Phe Ser Phe Tyr Gly Asp Tyr Gln Ser Glu Tyr Tyr Gly 
        275                 280                 285             


Pro Gly Gly Asn Tyr Asp Phe Phe Pro Gln Gly Pro Pro Ser Ser Gln 
    290                 295                 300                 


Ala Gln Thr Pro Val Asp Leu Pro Phe Val Pro Ser Ser Gly Pro Ser 
305                 310                 315                 320 


Gly Thr Pro Leu Gly Gly Leu Glu His Pro Leu Pro Gly His His Pro 
                325                 330                 335     


Ser Ser Glu Ala Gln Arg Phe Thr Asp Ile Leu Ala His Pro Pro Gly 
            340                 345                 350         


Asp Ser Pro Ser Pro Glu Pro Ser Leu Pro Gly Pro Leu His Ser Met 
        355                 360                 365             


Ser Ala Glu Val Phe Gly Pro Ser Pro Pro Phe Ser Ser Leu Ser Val 
    370                 375                 380                 


Asn Gly Gly Ala Ser Tyr Gly Asn His Leu Ser His Pro Pro Glu Met 
385                 390                 395                 400 


Asn Glu Ala Ala Val Trp 
                405     


<210>  113
<211>  825
<212>  DNA
<213>  Homo sapiens

<400>  113
atggcggcgc cggaggcgga ggttctgtcc tcagccgcag tccctgattt ggagtggtat       60

gagaagtccg aagaaactca cgcctcccag atagaactac ttgagacaag ctctacgcag      120

gaacctctca acgcttcgga ggccttttgc ccaagagact gcatggtacc agtggtgttt      180

cctgggcctg tgagccagga aggctgctgt cagtttactt gtgaacttct aaagcatatc      240

atgtatcaac gccagcagct ccctctgccc tatgaacagc ttaagcactt ttaccgaaaa      300

ccttctcccc aggcagagga gatgctgaag aagaaacctc gggccaccac tgaggtgagc      360

agcaggaaat gccaacaagc cctggcagaa ctggagagtg tcctcagcca cctggaggac      420

ttctttgcac ggacactagt accgcgagtg ctgattctcc ttgggggcaa tgccctaagc      480

cccaaggagt tctatgaact cgacttgtct ctgctggccc cctacagcgt ggaccagagc      540

ctgagcacag cagcttgttt gcgccgtctc ttccgagcca tattcatggc tgatgccttt      600

agcgagcttc aggctcctcc actcatgggc accgtcgtca tggcacaggg acaccgcaac      660

tgtggagaag attggtttcg acccaagctc aactatcgag tgcccagccg gggccataaa      720

ctgactgtga ccctgtcatg tggcagacct tccatccgaa ccacggcttg ggaagactac      780

atttggttcc aggcaccagt gacatttaaa ggcttccgcg agtga                      825


<210>  114
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Ala Ala Pro Glu Ala Glu Val Leu Ser Ser Ala Ala Val Pro Asp 
1               5                   10                  15      


Leu Glu Trp Tyr Glu Lys Ser Glu Glu Thr His Ala Ser Gln Ile Glu 
            20                  25                  30          


Leu Leu Glu Thr Ser Ser Thr Gln Glu Pro Leu Asn Ala Ser Glu Ala 
        35                  40                  45              


Phe Cys Pro Arg Asp Cys Met Val Pro Val Val Phe Pro Gly Pro Val 
    50                  55                  60                  


Ser Gln Glu Gly Cys Cys Gln Phe Thr Cys Glu Leu Leu Lys His Ile 
65                  70                  75                  80  


Met Tyr Gln Arg Gln Gln Leu Pro Leu Pro Tyr Glu Gln Leu Lys His 
                85                  90                  95      


Phe Tyr Arg Lys Pro Ser Pro Gln Ala Glu Glu Met Leu Lys Lys Lys 
            100                 105                 110         


Pro Arg Ala Thr Thr Glu Val Ser Ser Arg Lys Cys Gln Gln Ala Leu 
        115                 120                 125             


Ala Glu Leu Glu Ser Val Leu Ser His Leu Glu Asp Phe Phe Ala Arg 
    130                 135                 140                 


Thr Leu Val Pro Arg Val Leu Ile Leu Leu Gly Gly Asn Ala Leu Ser 
145                 150                 155                 160 


Pro Lys Glu Phe Tyr Glu Leu Asp Leu Ser Leu Leu Ala Pro Tyr Ser 
                165                 170                 175     


Val Asp Gln Ser Leu Ser Thr Ala Ala Cys Leu Arg Arg Leu Phe Arg 
            180                 185                 190         


Ala Ile Phe Met Ala Asp Ala Phe Ser Glu Leu Gln Ala Pro Pro Leu 
        195                 200                 205             


Met Gly Thr Val Val Met Ala Gln Gly His Arg Asn Cys Gly Glu Asp 
    210                 215                 220                 


Trp Phe Arg Pro Lys Leu Asn Tyr Arg Val Pro Ser Arg Gly His Lys 
225                 230                 235                 240 


Leu Thr Val Thr Leu Ser Cys Gly Arg Pro Ser Ile Arg Thr Thr Ala 
                245                 250                 255     


Trp Glu Asp Tyr Ile Trp Phe Gln Ala Pro Val Thr Phe Lys Gly Phe 
            260                 265                 270         


Arg Glu 
        


<210>  115
<211>  1200
<212>  DNA
<213>  Homo sapiens

<400>  115
atggcggctc cgagcccgag cggcggcggc ggctccgggg gcggcagcgg cagcggcacc       60

cccggccccg tagggtcccc ggcgccaggc cacccggccg tcagcagcat gcagggtaaa      120

cgcaaagcac tgaagttgaa ttttgcaaat ccacctttca aatctacagc aaggtttact      180

ctgaatccca atcctacagg agttcaaaac ccacacatag agagactgag aacacacagc      240

attgagtcat caggaaaact gaagatctcc cctgaacaac actgggattt cactgcagag      300

gacttgaaag accttggaga aattggacga ggagcttatg gttctgtcaa cagaatggtc      360

cacaaaccaa gtgggcaaat aatggcagtt aaaagaattc ggtcaacagt ggatgaaaaa      420

gaacaaaaac aacttcttat ggatttggat gtagtaatgc ggagtagtga ttgcccatac      480

attgttcagt tttatggtgc actcttcaga gagggtgact gttggatctg tatggaactc      540

atgtctacct cgtttgataa gttttacaaa tatgtatata gtgtattaga tgatgttatt      600

ccagaagaaa ttttaggcaa aatcacttta gcaactgtga aagcactaaa ccacttaaaa      660

gaaaacttga aaattattca cagagatatc aaaccttcca atattcttct ggacagaagt      720

ggaaatatta agctctgtga cttcggcatc agtggacagc ttgtggactc tattgccaag      780

acaagagatg ctggctgtag gccatacatg gcacctgaaa gaatagaccc aagcgcatca      840

cgacaaggat atgatgtccg ctctgatgtc tggagtttgg ggatcacatt gtatgagttg      900

gccacaggcc gatttcctta tccaaagtgg aatagtgtat ttgatcaact aacacaagtc      960

gtgaaaggag atcctccgca gctgagtaat tctgaggaaa gggaattctc cccgagtttc     1020

atcaactttg tcaacttgtg ccttacgaag gatgaatcca aaaggccaaa gtataaagag     1080

cttctgaaac atccctttat tttgatgtat gaagaacgtg ccgttgaggt cgcatgctat     1140

gtttgtaaaa tcctggatca aatgccagct actcccagct ctcccatgta tgtcgattga     1200


<210>  116
<211>  399
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Ala Ala Pro Ser Pro Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser 
1               5                   10                  15      


Gly Ser Gly Thr Pro Gly Pro Val Gly Ser Pro Ala Pro Gly His Pro 
            20                  25                  30          


Ala Val Ser Ser Met Gln Gly Lys Arg Lys Ala Leu Lys Leu Asn Phe 
        35                  40                  45              


Ala Asn Pro Pro Phe Lys Ser Thr Ala Arg Phe Thr Leu Asn Pro Asn 
    50                  55                  60                  


Pro Thr Gly Val Gln Asn Pro His Ile Glu Arg Leu Arg Thr His Ser 
65                  70                  75                  80  


Ile Glu Ser Ser Gly Lys Leu Lys Ile Ser Pro Glu Gln His Trp Asp 
                85                  90                  95      


Phe Thr Ala Glu Asp Leu Lys Asp Leu Gly Glu Ile Gly Arg Gly Ala 
            100                 105                 110         


Tyr Gly Ser Val Asn Arg Met Val His Lys Pro Ser Gly Gln Ile Met 
        115                 120                 125             


Ala Val Lys Arg Ile Arg Ser Thr Val Asp Glu Lys Glu Gln Lys Gln 
    130                 135                 140                 


Leu Leu Met Asp Leu Asp Val Val Met Arg Ser Ser Asp Cys Pro Tyr 
145                 150                 155                 160 


Ile Val Gln Phe Tyr Gly Ala Leu Phe Arg Glu Gly Asp Cys Trp Ile 
                165                 170                 175     


Cys Met Glu Leu Met Ser Thr Ser Phe Asp Lys Phe Tyr Lys Tyr Val 
            180                 185                 190         


Tyr Ser Val Leu Asp Asp Val Ile Pro Glu Glu Ile Leu Gly Lys Ile 
        195                 200                 205             


Thr Leu Ala Thr Val Lys Ala Leu Asn His Leu Lys Glu Asn Leu Lys 
    210                 215                 220                 


Ile Ile His Arg Asp Ile Lys Pro Ser Asn Ile Leu Leu Asp Arg Ser 
225                 230                 235                 240 


Gly Asn Ile Lys Leu Cys Asp Phe Gly Ile Ser Gly Gln Leu Val Asp 
                245                 250                 255     


Ser Ile Ala Lys Thr Arg Asp Ala Gly Cys Arg Pro Tyr Met Ala Pro 
            260                 265                 270         


Glu Arg Ile Asp Pro Ser Ala Ser Arg Gln Gly Tyr Asp Val Arg Ser 
        275                 280                 285             


Asp Val Trp Ser Leu Gly Ile Thr Leu Tyr Glu Leu Ala Thr Gly Arg 
    290                 295                 300                 


Phe Pro Tyr Pro Lys Trp Asn Ser Val Phe Asp Gln Leu Thr Gln Val 
305                 310                 315                 320 


Val Lys Gly Asp Pro Pro Gln Leu Ser Asn Ser Glu Glu Arg Glu Phe 
                325                 330                 335     


Ser Pro Ser Phe Ile Asn Phe Val Asn Leu Cys Leu Thr Lys Asp Glu 
            340                 345                 350         


Ser Lys Arg Pro Lys Tyr Lys Glu Leu Leu Lys His Pro Phe Ile Leu 
        355                 360                 365             


Met Tyr Glu Glu Arg Ala Val Glu Val Ala Cys Tyr Val Cys Lys Ile 
    370                 375                 380                 


Leu Asp Gln Met Pro Ala Thr Pro Ser Ser Pro Met Tyr Val Asp 
385                 390                 395                 


<210>  117
<211>  960
<212>  DNA
<213>  Homo sapiens

<400>  117
atggaactga tggatgccaa cttatgtcaa gtgattcaga tggaattaga ccatgagcga       60

atgtcttacc tgctgtacca aatgttgtgt ggcattaagc acctccattc tgctggaatt      120

attcacaggg atttaaaacc aagtaacatt gtagtcaagt ctgattgcac attgaaaatc      180

ctggactttg gactggccag gacagcaggc acaagcttca tgatgactcc atatgtggtg      240

acacgttatt acagagcccc tgaggtcatc ctggggatgg gctacaagga gaacgttgac      300

atgtggtcag tagggtgcat catgggagaa atgataaaag gtgcagtgct gtttcctggc      360

actgatcata ttgaccagtg gaataaggta attgaacaac taggaacacc atgtccagaa      420

ttcatgaaga aattgcaacc cacagtaaga aactatgtgg agaatcggcc caagtatgcg      480

ggactcacct tccccaaact cttcccagat tccctcttcc cagcggactc cgagcacaat      540

aaactcaaag ccagccaagc cagggacttg ttgtcaaaga tgctagtgat tgacccagca      600

aaaagaatat cagtggacga cgccttacag catccctaca tcaacgtctg gtatgaccca      660

gccgaagtgg aggcgcctcc acctcagata tatgacaagc agttggatga aagagaacac      720

acaattgaag aatggaaaga acttatctac aaggaagtaa tgaattcaga agaaaagact      780

aaaaatggtg tagtaaaagg acagccttct ccttcaggtg cagcagtgaa cagcagtgag      840

agtctccctc catcctcgtc tgtcaatgac atctcctcca tgtccaccga ccagaccctg      900

gcatctgaca ctgacagcag cctggaagcc tcggcaggac ccctgggttg ttgcaggtga      960


<210>  118
<211>  319
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Glu Leu Met Asp Ala Asn Leu Cys Gln Val Ile Gln Met Glu Leu 
1               5                   10                  15      


Asp His Glu Arg Met Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile 
            20                  25                  30          


Lys His Leu His Ser Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser 
        35                  40                  45              


Asn Ile Val Val Lys Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly 
    50                  55                  60                  


Leu Ala Arg Thr Ala Gly Thr Ser Phe Met Met Thr Pro Tyr Val Val 
65                  70                  75                  80  


Thr Arg Tyr Tyr Arg Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys 
                85                  90                  95      


Glu Asn Val Asp Met Trp Ser Val Gly Cys Ile Met Gly Glu Met Ile 
            100                 105                 110         


Lys Gly Ala Val Leu Phe Pro Gly Thr Asp His Ile Asp Gln Trp Asn 
        115                 120                 125             


Lys Val Ile Glu Gln Leu Gly Thr Pro Cys Pro Glu Phe Met Lys Lys 
    130                 135                 140                 


Leu Gln Pro Thr Val Arg Asn Tyr Val Glu Asn Arg Pro Lys Tyr Ala 
145                 150                 155                 160 


Gly Leu Thr Phe Pro Lys Leu Phe Pro Asp Ser Leu Phe Pro Ala Asp 
                165                 170                 175     


Ser Glu His Asn Lys Leu Lys Ala Ser Gln Ala Arg Asp Leu Leu Ser 
            180                 185                 190         


Lys Met Leu Val Ile Asp Pro Ala Lys Arg Ile Ser Val Asp Asp Ala 
        195                 200                 205             


Leu Gln His Pro Tyr Ile Asn Val Trp Tyr Asp Pro Ala Glu Val Glu 
    210                 215                 220                 


Ala Pro Pro Pro Gln Ile Tyr Asp Lys Gln Leu Asp Glu Arg Glu His 
225                 230                 235                 240 


Thr Ile Glu Glu Trp Lys Glu Leu Ile Tyr Lys Glu Val Met Asn Ser 
                245                 250                 255     


Glu Glu Lys Thr Lys Asn Gly Val Val Lys Gly Gln Pro Ser Pro Ser 
            260                 265                 270         


Gly Ala Ala Val Asn Ser Ser Glu Ser Leu Pro Pro Ser Ser Ser Val 
        275                 280                 285             


Asn Asp Ile Ser Ser Met Ser Thr Asp Gln Thr Leu Ala Ser Asp Thr 
    290                 295                 300                 


Asp Ser Ser Leu Glu Ala Ser Ala Gly Pro Leu Gly Cys Cys Arg 
305                 310                 315                 


<210>  119
<211>  1083
<212>  DNA
<213>  Homo sapiens

<400>  119
atgtctcagg agaggcccac gttctaccgg caggagctga acaagacaat ctgggaggtg       60

cccgagcgtt accagaacct gtctccagtg ggctctggcg cctatggctc tgtgtgtgct      120

gcttttgaca caaaaacggg gttacgtgtg gcagtgaaga agctctccag accatttcag      180

tccatcattc atgcgaaaag aacctacaga gaactgcggt tacttaaaca tatgaaacat      240

gaaaatgtga ttggtctgtt ggacgttttt acacctgcaa ggtctctgga ggaattcaat      300

gatgtgtatc tggtgaccca tctcatgggg gcagatctga acaacattgt gaaatgtcag      360

aagcttacag atgaccatgt tcagttcctt atctaccaaa ttctccgagg tctaaagtat      420

atacattcag ctgacataat tcacagggac ctaaaaccta gtaatctagc tgtgaatgaa      480

gactgtgagc tgaagattct ggattttgga ctggctcggc acacagatga tgaaatgaca      540

ggctacgtgg ccactaggtg gtacagggct cctgagatca tgctgaactg gatgcattac      600

aaccagacag ttgatatttg gtcagtggga tgcataatgg ccgagctgtt gactggaaga      660

acattgtttc ctggtacaga ccatattgat cagttgaagc tcattttaag actcgttgga      720

accccagggg ctgagctttt gaagaaaatc tcctcagagt ctgcaagaaa ctatattcag      780

tctttgactc agatgccgaa gatgaacttt gcgaatgtat ttattggtgc caatcccctg      840

gctgtcgact tgctggagaa gatgcttgta ttggactcag ataagagaat tacagcggcc      900

caagcccttg cacatgccta ctttgctcag taccacgatc ctgatgatga accagtggcc      960

gatccttatg atcagtcctt tgaaagcagg gacctcctta tagatgagtg gaaaagcctg     1020

acctatgatg aagtcatcag ctttgtgcca ccaccccttg accaagaaga gatggagtcc     1080

tga                                                                   1083


<210>  120
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Ser Gln Glu Arg Pro Thr Phe Tyr Arg Gln Glu Leu Asn Lys Thr 
1               5                   10                  15      


Ile Trp Glu Val Pro Glu Arg Tyr Gln Asn Leu Ser Pro Val Gly Ser 
            20                  25                  30          


Gly Ala Tyr Gly Ser Val Cys Ala Ala Phe Asp Thr Lys Thr Gly Leu 
        35                  40                  45              


Arg Val Ala Val Lys Lys Leu Ser Arg Pro Phe Gln Ser Ile Ile His 
    50                  55                  60                  


Ala Lys Arg Thr Tyr Arg Glu Leu Arg Leu Leu Lys His Met Lys His 
65                  70                  75                  80  


Glu Asn Val Ile Gly Leu Leu Asp Val Phe Thr Pro Ala Arg Ser Leu 
                85                  90                  95      


Glu Glu Phe Asn Asp Val Tyr Leu Val Thr His Leu Met Gly Ala Asp 
            100                 105                 110         


Leu Asn Asn Ile Val Lys Cys Gln Lys Leu Thr Asp Asp His Val Gln 
        115                 120                 125             


Phe Leu Ile Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala 
    130                 135                 140                 


Asp Ile Ile His Arg Asp Leu Lys Pro Ser Asn Leu Ala Val Asn Glu 
145                 150                 155                 160 


Asp Cys Glu Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg His Thr Asp 
                165                 170                 175     


Asp Glu Met Thr Gly Tyr Val Ala Thr Arg Trp Tyr Arg Ala Pro Glu 
            180                 185                 190         


Ile Met Leu Asn Trp Met His Tyr Asn Gln Thr Val Asp Ile Trp Ser 
        195                 200                 205             


Val Gly Cys Ile Met Ala Glu Leu Leu Thr Gly Arg Thr Leu Phe Pro 
    210                 215                 220                 


Gly Thr Asp His Ile Asp Gln Leu Lys Leu Ile Leu Arg Leu Val Gly 
225                 230                 235                 240 


Thr Pro Gly Ala Glu Leu Leu Lys Lys Ile Ser Ser Glu Ser Ala Arg 
                245                 250                 255     


Asn Tyr Ile Gln Ser Leu Thr Gln Met Pro Lys Met Asn Phe Ala Asn 
            260                 265                 270         


Val Phe Ile Gly Ala Asn Pro Leu Ala Val Asp Leu Leu Glu Lys Met 
        275                 280                 285             


Leu Val Leu Asp Ser Asp Lys Arg Ile Thr Ala Ala Gln Ala Leu Ala 
    290                 295                 300                 


His Ala Tyr Phe Ala Gln Tyr His Asp Pro Asp Asp Glu Pro Val Ala 
305                 310                 315                 320 


Asp Pro Tyr Asp Gln Ser Phe Glu Ser Arg Asp Leu Leu Ile Asp Glu 
                325                 330                 335     


Trp Lys Ser Leu Thr Tyr Asp Glu Val Ile Ser Phe Val Pro Pro Pro 
            340                 345                 350         


Leu Asp Gln Glu Glu Met Glu Ser 
        355                 360 


<210>  121
<211>  1149
<212>  DNA
<213>  Homo sapiens

<400>  121
atggatggtg aaacagcaga ggagcagggg ggccctgtgc ccccgccagt tgcacccggc       60

ggacccggct tgggcggtgc tccggggggg cggcgggagc ccaagaagta cgcagtgacc      120

gacgactacc agttgtccaa gcaggtgctg ggcctgggtg tgaacggcaa agtgctggag      180

tgcttccatc ggcgcactgg acagaagtgt gccctgaagc tcctgtatga cagccccaag      240

gcccggcagg aggtagacca tcactggcag gcttctggcg gcccccatat tgtctgcatc      300

ctggatgtgt atgagaacat gcaccatggc aagcgctgtc tcctcatcat catggaatgc      360

atggaaggtg gtgagttgtt cagcaggatt caggagcgtg gcgaccaggc tttcactgag      420

agagaagctg cagagataat gcgggatatt ggcactgcca tccagtttct gcacagccat      480

aacattgccc accgagatgt caagcctgaa aacctactct acacatctaa ggagaaagac      540

gcagtgctta agctcaccga ttttggcttt gctaaggaga ccacccaaaa tgccctgcag      600

acaccctgct atactcccta ttatgtggcc cctgaggtcc tgggtccaga gaagtatgac      660

aagtcatgtg acatgtggtc cctgggtgtc atcatgtaca tcctcctttg tggcttccca      720

cccttctact ccaacacggg ccaggccatc tccccgggga tgaagaggag gattcgcctg      780

ggccagtacg gcttccccaa tcctgagtgg tcagaagtct ctgaggatgc caagcagctg      840

atccgcctcc tgttgaagac agaccccaca gagaggctga ccatcactca gttcatgaac      900

cacccctgga tcaaccaatc gatggtagtg ccacagaccc cactccacac ggcccgagtg      960

ctgcaggagg acaaagacca ctgggacgaa gtcaaggagg agatgaccag tgccttggcc     1020

actatgcggg tagactacga ccaggtgaag atcaaggacc tgaagacctc taacaaccgg     1080

ctcctcaaca agaggagaaa aaagcaggca ggcagctcct ctgcctcaca gggctgcaac     1140

aaccagtag                                                             1149


<210>  122
<211>  382
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Asp Gly Glu Thr Ala Glu Glu Gln Gly Gly Pro Val Pro Pro Pro 
1               5                   10                  15      


Val Ala Pro Gly Gly Pro Gly Leu Gly Gly Ala Pro Gly Gly Arg Arg 
            20                  25                  30          


Glu Pro Lys Lys Tyr Ala Val Thr Asp Asp Tyr Gln Leu Ser Lys Gln 
        35                  40                  45              


Val Leu Gly Leu Gly Val Asn Gly Lys Val Leu Glu Cys Phe His Arg 
    50                  55                  60                  


Arg Thr Gly Gln Lys Cys Ala Leu Lys Leu Leu Tyr Asp Ser Pro Lys 
65                  70                  75                  80  


Ala Arg Gln Glu Val Asp His His Trp Gln Ala Ser Gly Gly Pro His 
                85                  90                  95      


Ile Val Cys Ile Leu Asp Val Tyr Glu Asn Met His His Gly Lys Arg 
            100                 105                 110         


Cys Leu Leu Ile Ile Met Glu Cys Met Glu Gly Gly Glu Leu Phe Ser 
        115                 120                 125             


Arg Ile Gln Glu Arg Gly Asp Gln Ala Phe Thr Glu Arg Glu Ala Ala 
    130                 135                 140                 


Glu Ile Met Arg Asp Ile Gly Thr Ala Ile Gln Phe Leu His Ser His 
145                 150                 155                 160 


Asn Ile Ala His Arg Asp Val Lys Pro Glu Asn Leu Leu Tyr Thr Ser 
                165                 170                 175     


Lys Glu Lys Asp Ala Val Leu Lys Leu Thr Asp Phe Gly Phe Ala Lys 
            180                 185                 190         


Glu Thr Thr Gln Asn Ala Leu Gln Thr Pro Cys Tyr Thr Pro Tyr Tyr 
        195                 200                 205             


Val Ala Pro Glu Val Leu Gly Pro Glu Lys Tyr Asp Lys Ser Cys Asp 
    210                 215                 220                 


Met Trp Ser Leu Gly Val Ile Met Tyr Ile Leu Leu Cys Gly Phe Pro 
225                 230                 235                 240 


Pro Phe Tyr Ser Asn Thr Gly Gln Ala Ile Ser Pro Gly Met Lys Arg 
                245                 250                 255     


Arg Ile Arg Leu Gly Gln Tyr Gly Phe Pro Asn Pro Glu Trp Ser Glu 
            260                 265                 270         


Val Ser Glu Asp Ala Lys Gln Leu Ile Arg Leu Leu Leu Lys Thr Asp 
        275                 280                 285             


Pro Thr Glu Arg Leu Thr Ile Thr Gln Phe Met Asn His Pro Trp Ile 
    290                 295                 300                 


Asn Gln Ser Met Val Val Pro Gln Thr Pro Leu His Thr Ala Arg Val 
305                 310                 315                 320 


Leu Gln Glu Asp Lys Asp His Trp Asp Glu Val Lys Glu Glu Met Thr 
                325                 330                 335     


Ser Ala Leu Ala Thr Met Arg Val Asp Tyr Asp Gln Val Lys Ile Lys 
            340                 345                 350         


Asp Leu Lys Thr Ser Asn Asn Arg Leu Leu Asn Lys Arg Arg Lys Lys 
        355                 360                 365             


Gln Ala Gly Ser Ser Ser Ala Ser Gln Gly Cys Asn Asn Gln 
    370                 375                 380         


<210>  123
<211>  521
<212>  DNA
<213>  Homo sapiens

<400>  123
atggcagtga acgtatactc aacgtcagtg accagtgata acctaagtcg acatgacatg       60

ctggcctgga tcaatgagtc tctgcagttg aatctgacaa agatcgaaca gttgtgctca      120

ggggctgcgt attgtcagtt tatggacatg ctgttccctg gctccattgc cttgaagaaa      180

gtgaaattcc aagctaagct agaacacgag tacatccaga acttcaaaat actacaagca      240

ggttttaaga gaatgggtgt tgacaaaata attcctgtgg acaaattagt aaaaggaaag      300

tttcaggaca attttgaatt cgttcagtgg ttcaagaagt ttttcgatgc aaactatgat      360

ggaaaagact atgaccctgt ggctgccaga caaggtcaag aaactgcagt ggctccttcc      420

cttgttgctc cagctctgaa taaaccgaag aaacctctca cttctagcag tgcagctccc      480

cagaggccca tctcaacaca gagaaccgct gctccccaaa t                          521


<210>  124
<211>  173
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Ala Val Asn Val Tyr Ser Thr Ser Val Thr Ser Asp Asn Leu Ser 
1               5                   10                  15      


Arg His Asp Met Leu Ala Trp Ile Asn Glu Ser Leu Gln Leu Asn Leu 
            20                  25                  30          


Thr Lys Ile Glu Gln Leu Cys Ser Gly Ala Ala Tyr Cys Gln Phe Met 
        35                  40                  45              


Asp Met Leu Phe Pro Gly Ser Ile Ala Leu Lys Lys Val Lys Phe Gln 
    50                  55                  60                  


Ala Lys Leu Glu His Glu Tyr Ile Gln Asn Phe Lys Ile Leu Gln Ala 
65                  70                  75                  80  


Gly Phe Lys Arg Met Gly Val Asp Lys Ile Ile Pro Val Asp Lys Leu 
                85                  90                  95      


Val Lys Gly Lys Phe Gln Asp Asn Phe Glu Phe Val Gln Trp Phe Lys 
            100                 105                 110         


Lys Phe Phe Asp Ala Asn Tyr Asp Gly Lys Asp Tyr Asp Pro Val Ala 
        115                 120                 125             


Ala Arg Gln Gly Gln Glu Thr Ala Val Ala Pro Ser Leu Val Ala Pro 
    130                 135                 140                 


Ala Leu Asn Lys Pro Lys Lys Pro Leu Thr Ser Ser Ser Ala Ala Pro 
145                 150                 155                 160 


Gln Arg Pro Ile Ser Thr Gln Arg Thr Ala Ala Pro Gln 
                165                 170             


<210>  125
<211>  1941
<212>  DNA
<213>  Homo sapiens

<400>  125
atggggcttc ccaggctggt ctgcgccttc ttgctcgccg cctgctgctg ctgtcctcgc       60

gtcgcgggtg tgcccggaga ggctgagcag cctgcgcctg agctggtgga ggtggaagtg      120

ggcagcacag cccttctgaa gtgcggcctc tcccagtccc aaggcaacct cagccatgtc      180

gactggtttt ctgtccacaa ggagaagcgg acgctcatct tccgtgtgcg ccagggccag      240

ggccagagcg aacctgggga gtacgagcag cggctcagcc tccaggacag aggggctact      300

ctggccctga ctcaagtcac cccccaagac gagcgcatct tcttgtgcca gggcaagcgc      360

cctcggtccc aggagtaccg catccagctc cgcgtctaca aagctccgga ggagccaaac      420

atccaggtca accccctggg catccctgtg aacagtaagg agcctgagga ggtcgctacc      480

tgtgtaggga ggaacgggta ccccattcct caagtcatct ggtacaagaa tggccggcct      540

ctgaaggagg agaagaaccg ggtccacatt cagtcgtccc agactgtgga gtcgagtggt      600

ttgtacacct tgcagagtat tctgaaggca cagctggtta aagaagacaa agatgcccag      660

ttttactgtg agctcaacta ccggctgccc agtgggaacc acatgaagga gtccagggaa      720

gtcaccgtcc ctgttttcta cccgacagaa aaagtgtggc tggaagtgga gcccgtggga      780

atgctgaagg aaggggaccg cgtggaaatc aggtgtttgg ctgatggcaa ccctccacca      840

cacttcagca tcagcaagca gaaccccagc accagggagg cagaggaaga gacaaccaac      900

gacaacgggg tcctggtgct ggagcctgcc cggaaggaac acagtgggcg ctatgaatgt      960

cagggcctgg acttggacac catgatatcg ctgctgagtg aaccacagga actactggtg     1020

aactatgtgt ctgacgtccg agtgagtccc gcagcccctg agagacagga aggcagcagc     1080

ctcaccctga cctgtgaggc agagagtagc caggacctcg agttccagtg gctgagagaa     1140

gagacaggcc aggtgctgga aagggggcct gtgcttcagt tgcatgacct gaaacgggag     1200

gcaggaggcg gctatcgctg cgtggcgtct gtgcccagca tacccggcct gaaccgcaca     1260

cagctggtca acgtggccat ttttggcccc ccttggatgg cattcaagga gaggaaggtg     1320

tgggtgaaag agaatatggt gttgaatctg tcttgtgaag cgtcagggca cccccggccc     1380

accatctcct ggaacgtcaa cggcacggca agtgaacaag accaagatcc acagcgagtc     1440

ctgagcaccc tgaatgtcct cgtgaccccg gagctgttgg agacaggtgt tgaatgcacg     1500

gcctccaacg acctgggcaa aaacaccagc atcctcttcc tggagctggt caatttaacc     1560

accctcacac cagactccaa cacaaccact ggcctcagca cttccactgc cagtcctcat     1620

accagagcca acagcacctc cacagagaga aagctgccgg agccggagag ccggggcgtg     1680

gtcatcgtgg ctgtgattgt gtgcatcctg gtcctggcgg tgctgggcgc tgtcctctat     1740

ttcctctata agaagggcaa gctgccgtgc aggcgctcag ggaagcagga gatcacgcta     1800

cccccgtctc gtaagagcga acttgtagtt gaagttaagt cagataagct cccagaagag     1860

atgggcctcc tgcagggcag cagcggtgac aagagggctc cgggagacca gggagagaaa     1920

tacatcgatc tgaggcatta g                                               1941


<210>  126
<211>  646
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Gly Leu Pro Arg Leu Val Cys Ala Phe Leu Leu Ala Ala Cys Cys 
1               5                   10                  15      


Cys Cys Pro Arg Val Ala Gly Val Pro Gly Glu Ala Glu Gln Pro Ala 
            20                  25                  30          


Pro Glu Leu Val Glu Val Glu Val Gly Ser Thr Ala Leu Leu Lys Cys 
        35                  40                  45              


Gly Leu Ser Gln Ser Gln Gly Asn Leu Ser His Val Asp Trp Phe Ser 
    50                  55                  60                  


Val His Lys Glu Lys Arg Thr Leu Ile Phe Arg Val Arg Gln Gly Gln 
65                  70                  75                  80  


Gly Gln Ser Glu Pro Gly Glu Tyr Glu Gln Arg Leu Ser Leu Gln Asp 
                85                  90                  95      


Arg Gly Ala Thr Leu Ala Leu Thr Gln Val Thr Pro Gln Asp Glu Arg 
            100                 105                 110         


Ile Phe Leu Cys Gln Gly Lys Arg Pro Arg Ser Gln Glu Tyr Arg Ile 
        115                 120                 125             


Gln Leu Arg Val Tyr Lys Ala Pro Glu Glu Pro Asn Ile Gln Val Asn 
    130                 135                 140                 


Pro Leu Gly Ile Pro Val Asn Ser Lys Glu Pro Glu Glu Val Ala Thr 
145                 150                 155                 160 


Cys Val Gly Arg Asn Gly Tyr Pro Ile Pro Gln Val Ile Trp Tyr Lys 
                165                 170                 175     


Asn Gly Arg Pro Leu Lys Glu Glu Lys Asn Arg Val His Ile Gln Ser 
            180                 185                 190         


Ser Gln Thr Val Glu Ser Ser Gly Leu Tyr Thr Leu Gln Ser Ile Leu 
        195                 200                 205             


Lys Ala Gln Leu Val Lys Glu Asp Lys Asp Ala Gln Phe Tyr Cys Glu 
    210                 215                 220                 


Leu Asn Tyr Arg Leu Pro Ser Gly Asn His Met Lys Glu Ser Arg Glu 
225                 230                 235                 240 


Val Thr Val Pro Val Phe Tyr Pro Thr Glu Lys Val Trp Leu Glu Val 
                245                 250                 255     


Glu Pro Val Gly Met Leu Lys Glu Gly Asp Arg Val Glu Ile Arg Cys 
            260                 265                 270         


Leu Ala Asp Gly Asn Pro Pro Pro His Phe Ser Ile Ser Lys Gln Asn 
        275                 280                 285             


Pro Ser Thr Arg Glu Ala Glu Glu Glu Thr Thr Asn Asp Asn Gly Val 
    290                 295                 300                 


Leu Val Leu Glu Pro Ala Arg Lys Glu His Ser Gly Arg Tyr Glu Cys 
305                 310                 315                 320 


Gln Gly Leu Asp Leu Asp Thr Met Ile Ser Leu Leu Ser Glu Pro Gln 
                325                 330                 335     


Glu Leu Leu Val Asn Tyr Val Ser Asp Val Arg Val Ser Pro Ala Ala 
            340                 345                 350         


Pro Glu Arg Gln Glu Gly Ser Ser Leu Thr Leu Thr Cys Glu Ala Glu 
        355                 360                 365             


Ser Ser Gln Asp Leu Glu Phe Gln Trp Leu Arg Glu Glu Thr Gly Gln 
    370                 375                 380                 


Val Leu Glu Arg Gly Pro Val Leu Gln Leu His Asp Leu Lys Arg Glu 
385                 390                 395                 400 


Ala Gly Gly Gly Tyr Arg Cys Val Ala Ser Val Pro Ser Ile Pro Gly 
                405                 410                 415     


Leu Asn Arg Thr Gln Leu Val Asn Val Ala Ile Phe Gly Pro Pro Trp 
            420                 425                 430         


Met Ala Phe Lys Glu Arg Lys Val Trp Val Lys Glu Asn Met Val Leu 
        435                 440                 445             


Asn Leu Ser Cys Glu Ala Ser Gly His Pro Arg Pro Thr Ile Ser Trp 
    450                 455                 460                 


Asn Val Asn Gly Thr Ala Ser Glu Gln Asp Gln Asp Pro Gln Arg Val 
465                 470                 475                 480 


Leu Ser Thr Leu Asn Val Leu Val Thr Pro Glu Leu Leu Glu Thr Gly 
                485                 490                 495     


Val Glu Cys Thr Ala Ser Asn Asp Leu Gly Lys Asn Thr Ser Ile Leu 
            500                 505                 510         


Phe Leu Glu Leu Val Asn Leu Thr Thr Leu Thr Pro Asp Ser Asn Thr 
        515                 520                 525             


Thr Thr Gly Leu Ser Thr Ser Thr Ala Ser Pro His Thr Arg Ala Asn 
    530                 535                 540                 


Ser Thr Ser Thr Glu Arg Lys Leu Pro Glu Pro Glu Ser Arg Gly Val 
545                 550                 555                 560 


Val Ile Val Ala Val Ile Val Cys Ile Leu Val Leu Ala Val Leu Gly 
                565                 570                 575     


Ala Val Leu Tyr Phe Leu Tyr Lys Lys Gly Lys Leu Pro Cys Arg Arg 
            580                 585                 590         


Ser Gly Lys Gln Glu Ile Thr Leu Pro Pro Ser Arg Lys Ser Glu Leu 
        595                 600                 605             


Val Val Glu Val Lys Ser Asp Lys Leu Pro Glu Glu Met Gly Leu Leu 
    610                 615                 620                 


Gln Gly Ser Ser Gly Asp Lys Arg Ala Pro Gly Asp Gln Gly Glu Lys 
625                 630                 635                 640 


Tyr Ile Asp Leu Arg His 
                645     


<210>  127
<211>  2592
<212>  DNA
<213>  Homo sapiens

<400>  127
atgtcgtccc cggcgtcgac cccgagccgc cgcggcagcc ggcgtggaag ggccaccccc       60

gcccagacgc ctcggagtga ggatgccagg tcatctccct ctcagagacg tagaggcgag      120

gattccacct ccacggggga gttgcagccg atgccaacct cgcctggagt ggacctgcag      180

agccctgctg cgcaggacgt gctgttttcc agccctcccc aaatgcattc ttcagctatc      240

cctcttgact ttgatgttag ttcaccactg acatacggca ctcccagctc tcgggtagag      300

ggaaccccaa gaagtggtgt taggggcaca cctgtgagac agaggcctga cctgggctct      360

gcacagaagg gcctgcaagt ggatctgcag tctgacgggg cagcagcaga agatatagtg      420

gcaagtgagc agtctctagg ccaaaaactt gtgatctggg gaacagatgt aaatgtggca      480

gcatgcaaag aaaactttca gagatttctt cagcgtttta ttgaccctct ggctaaagaa      540

gaagaaaatg ttggcataga tattactgaa cctctataca tgcaacgact tggggagatt      600

aatgttattg gtgagccatt tttaaatgtg aactgtgaac acatcaaatc atttgacaaa      660

aatttgtaca gacaactcat ctcttaccca caggaagtta ttccaacttt tgacatggct      720

gtcaatgaaa tcttctttga ccgttaccct gactcaatct tagaacatca gattcaagta      780

agaccattca acgcattgaa gactaagaat atgagaaacc tgaatccaga agacattgac      840

cagctcatca ccatcagcgg catggtgatc aggacatccc agctgattcc cgagatgcag      900

gaggccttct tccagtgcca agtgtgtgcc cacacgaccc gggtggagat ggaccgcggc      960

cgcattgcag agcccagtgt gtgcgggcgc tgccacacca cccacagcat ggcactcatc     1020

cacaaccgct ccctcttctc tgacaagcag atgatcaagc ttcaggagtc tccggaagac     1080

atgcctgcag ggcagacacc acacacagtt atcctgtttg ctcacaatga tctcgttgac     1140

aaggtccagc ctggggacag agtgaatgtt acaggcatct atcgagctgt gcctattcga     1200

gtcaatccaa gagtgagtaa tgtgaagtct gtctacaaaa cccacattga tgtcattcat     1260

tatcggaaaa cggatgcaaa acgtctgcat ggccttgatg aagaagcaga acagaaactt     1320

ttttcagaga aacgtgtgga attgcttaag gaactttcca ggaaaccaga catttatgag     1380

aggcttgctt cagccttggc tccaagcatt tatgaacatg aagatataaa gaagggaatt     1440

ttgcttcagc tctttggcgg gacaaggaag gattttagtc acactggaag gggcaaattt     1500

cgggctgaga tcaacatctt gctgtgtggc gaccctggta ccagcaagtc ccagctgctg     1560

cagtacgtgt acaacctcgt ccccaggggc cagtacacgt ctgggaaggg ctccagtgca     1620

gttggcctca ctgcgtacgt aatgaaagac cctgagacaa ggcagctggt cctgcagaca     1680

ggtgctcttg tcctgagtga caacggcatc tgctgtatcg atgagttcga caagatgaat     1740

gaaagtacaa gatcggtatt gcatgaagtc atggaacagc agactctgtc cattgcaaag     1800

gctgggatca tctgtcagct caatgcgcgc acctctgtcc tggcagcagc aaatcccatt     1860

gagtctcagt ggaatcctaa aaaaacaacc attgaaaaca tccagctgcc tcatacttta     1920

ttatcaaggt ttgatttgat cttcctcttg ctggaccctc aggacgaagc ctatgacagg     1980

cgtctggctc accacctggt cgcactgtac taccagagcg aggagcaggc agaggaggag     2040

ctcctggaca tggcggtgct aaaggactac attgcctacg cgcacagcac catcatgccg     2100

cggctaagtg aggaagccag ccaggctctc atcgaggctt atgtagacat gaggaagatt     2160

ggcagtagcc ggggaatggt ttctgcatac cctcgacagc tagagtcatt aatccgctta     2220

gcagaagccc atgctaaagt aagattgtct aacaaagttg aagccattga tgtggaagag     2280

gccaaacgcc tccatcggga agctctgaag cagtctgcaa ctgatccccg gactggcatc     2340

gtggacatat ctattcttac tacggggatg agtgccacct ctcgtaaacg gaaagaagaa     2400

ttagctgaag cattgaaaaa gcttatttta tctaagggca aaacaccagc tctaaaatac     2460

cagcaacttt ttgaagatat tcggggacaa tctgacatag caattactaa agatatgttt     2520

gaagaagcac tgcgtgccct ggcagatgat gatttcctga cagtgactgg gaagaccgtg     2580

cgcttgctct ga                                                         2592


<210>  128
<211>  863
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Ser Ser Pro Ala Ser Thr Pro Ser Arg Arg Gly Ser Arg Arg Gly 
1               5                   10                  15      


Arg Ala Thr Pro Ala Gln Thr Pro Arg Ser Glu Asp Ala Arg Ser Ser 
            20                  25                  30          


Pro Ser Gln Arg Arg Arg Gly Glu Asp Ser Thr Ser Thr Gly Glu Leu 
        35                  40                  45              


Gln Pro Met Pro Thr Ser Pro Gly Val Asp Leu Gln Ser Pro Ala Ala 
    50                  55                  60                  


Gln Asp Val Leu Phe Ser Ser Pro Pro Gln Met His Ser Ser Ala Ile 
65                  70                  75                  80  


Pro Leu Asp Phe Asp Val Ser Ser Pro Leu Thr Tyr Gly Thr Pro Ser 
                85                  90                  95      


Ser Arg Val Glu Gly Thr Pro Arg Ser Gly Val Arg Gly Thr Pro Val 
            100                 105                 110         


Arg Gln Arg Pro Asp Leu Gly Ser Ala Gln Lys Gly Leu Gln Val Asp 
        115                 120                 125             


Leu Gln Ser Asp Gly Ala Ala Ala Glu Asp Ile Val Ala Ser Glu Gln 
    130                 135                 140                 


Ser Leu Gly Gln Lys Leu Val Ile Trp Gly Thr Asp Val Asn Val Ala 
145                 150                 155                 160 


Ala Cys Lys Glu Asn Phe Gln Arg Phe Leu Gln Arg Phe Ile Asp Pro 
                165                 170                 175     


Leu Ala Lys Glu Glu Glu Asn Val Gly Ile Asp Ile Thr Glu Pro Leu 
            180                 185                 190         


Tyr Met Gln Arg Leu Gly Glu Ile Asn Val Ile Gly Glu Pro Phe Leu 
        195                 200                 205             


Asn Val Asn Cys Glu His Ile Lys Ser Phe Asp Lys Asn Leu Tyr Arg 
    210                 215                 220                 


Gln Leu Ile Ser Tyr Pro Gln Glu Val Ile Pro Thr Phe Asp Met Ala 
225                 230                 235                 240 


Val Asn Glu Ile Phe Phe Asp Arg Tyr Pro Asp Ser Ile Leu Glu His 
                245                 250                 255     


Gln Ile Gln Val Arg Pro Phe Asn Ala Leu Lys Thr Lys Asn Met Arg 
            260                 265                 270         


Asn Leu Asn Pro Glu Asp Ile Asp Gln Leu Ile Thr Ile Ser Gly Met 
        275                 280                 285             


Val Ile Arg Thr Ser Gln Leu Ile Pro Glu Met Gln Glu Ala Phe Phe 
    290                 295                 300                 


Gln Cys Gln Val Cys Ala His Thr Thr Arg Val Glu Met Asp Arg Gly 
305                 310                 315                 320 


Arg Ile Ala Glu Pro Ser Val Cys Gly Arg Cys His Thr Thr His Ser 
                325                 330                 335     


Met Ala Leu Ile His Asn Arg Ser Leu Phe Ser Asp Lys Gln Met Ile 
            340                 345                 350         


Lys Leu Gln Glu Ser Pro Glu Asp Met Pro Ala Gly Gln Thr Pro His 
        355                 360                 365             


Thr Val Ile Leu Phe Ala His Asn Asp Leu Val Asp Lys Val Gln Pro 
    370                 375                 380                 


Gly Asp Arg Val Asn Val Thr Gly Ile Tyr Arg Ala Val Pro Ile Arg 
385                 390                 395                 400 


Val Asn Pro Arg Val Ser Asn Val Lys Ser Val Tyr Lys Thr His Ile 
                405                 410                 415     


Asp Val Ile His Tyr Arg Lys Thr Asp Ala Lys Arg Leu His Gly Leu 
            420                 425                 430         


Asp Glu Glu Ala Glu Gln Lys Leu Phe Ser Glu Lys Arg Val Glu Leu 
        435                 440                 445             


Leu Lys Glu Leu Ser Arg Lys Pro Asp Ile Tyr Glu Arg Leu Ala Ser 
    450                 455                 460                 


Ala Leu Ala Pro Ser Ile Tyr Glu His Glu Asp Ile Lys Lys Gly Ile 
465                 470                 475                 480 


Leu Leu Gln Leu Phe Gly Gly Thr Arg Lys Asp Phe Ser His Thr Gly 
                485                 490                 495     


Arg Gly Lys Phe Arg Ala Glu Ile Asn Ile Leu Leu Cys Gly Asp Pro 
            500                 505                 510         


Gly Thr Ser Lys Ser Gln Leu Leu Gln Tyr Val Tyr Asn Leu Val Pro 
        515                 520                 525             


Arg Gly Gln Tyr Thr Ser Gly Lys Gly Ser Ser Ala Val Gly Leu Thr 
    530                 535                 540                 


Ala Tyr Val Met Lys Asp Pro Glu Thr Arg Gln Leu Val Leu Gln Thr 
545                 550                 555                 560 


Gly Ala Leu Val Leu Ser Asp Asn Gly Ile Cys Cys Ile Asp Glu Phe 
                565                 570                 575     


Asp Lys Met Asn Glu Ser Thr Arg Ser Val Leu His Glu Val Met Glu 
            580                 585                 590         


Gln Gln Thr Leu Ser Ile Ala Lys Ala Gly Ile Ile Cys Gln Leu Asn 
        595                 600                 605             


Ala Arg Thr Ser Val Leu Ala Ala Ala Asn Pro Ile Glu Ser Gln Trp 
    610                 615                 620                 


Asn Pro Lys Lys Thr Thr Ile Glu Asn Ile Gln Leu Pro His Thr Leu 
625                 630                 635                 640 


Leu Ser Arg Phe Asp Leu Ile Phe Leu Leu Leu Asp Pro Gln Asp Glu 
                645                 650                 655     


Ala Tyr Asp Arg Arg Leu Ala His His Leu Val Ala Leu Tyr Tyr Gln 
            660                 665                 670         


Ser Glu Glu Gln Ala Glu Glu Glu Leu Leu Asp Met Ala Val Leu Lys 
        675                 680                 685             


Asp Tyr Ile Ala Tyr Ala His Ser Thr Ile Met Pro Arg Leu Ser Glu 
    690                 695                 700                 


Glu Ala Ser Gln Ala Leu Ile Glu Ala Tyr Val Asp Met Arg Lys Ile 
705                 710                 715                 720 


Gly Ser Ser Arg Gly Met Val Ser Ala Tyr Pro Arg Gln Leu Glu Ser 
                725                 730                 735     


Leu Ile Arg Leu Ala Glu Ala His Ala Lys Val Arg Leu Ser Asn Lys 
            740                 745                 750         


Val Glu Ala Ile Asp Val Glu Glu Ala Lys Arg Leu His Arg Glu Ala 
        755                 760                 765             


Leu Lys Gln Ser Ala Thr Asp Pro Arg Thr Gly Ile Val Asp Ile Ser 
    770                 775                 780                 


Ile Leu Thr Thr Gly Met Ser Ala Thr Ser Arg Lys Arg Lys Glu Glu 
785                 790                 795                 800 


Leu Ala Glu Ala Leu Lys Lys Leu Ile Leu Ser Lys Gly Lys Thr Pro 
                805                 810                 815     


Ala Leu Lys Tyr Gln Gln Leu Phe Glu Asp Ile Arg Gly Gln Ser Asp 
            820                 825                 830         


Ile Ala Ile Thr Lys Asp Met Phe Glu Glu Ala Leu Arg Ala Leu Ala 
        835                 840                 845             


Asp Asp Asp Phe Leu Thr Val Thr Gly Lys Thr Val Arg Leu Leu 
    850                 855                 860             


<210>  129
<211>  2466
<212>  DNA
<213>  Homo sapiens

<400>  129
atggacctcg cggcggcagc ggagccgggc gccggcagcc agcacctgga ggtccgcgac       60

gaggtggccg agaagtgcca gaaactgttc ctggacttct tggaggagtt tcagagcagc      120

gatggagaaa ttaaatactt gcaattagca gaggaactga ttcgtcctga gagaaacaca      180

ttggttgtga gttttgtgga cctggaacaa tttaaccagc aactttccac caccattcaa      240

gaggagttct atagagttta cccttacctg tgtcgggcct tgaaaacatt cgtcaaagac      300

cgtaaagaga tccctcttgc caaggatttt tatgttgcat tccaagacct gcctaccaga      360

cacaagattc gagagctcac ctcatccaga attggtttgc tcactcgcat cagtgggcag      420

gtggtgcgga ctcacccagt tcacccagag cttgtgagcg gaacttttct gtgcttggac      480

tgtcagacag tgatcaggga tgtagaacag cagttcaaat acacacagcc aaacatctgc      540

cgaaatccag tttgtgccaa caggaggaga ttcttactgg atacaaataa atcaagattt      600

gttgattttc aaaaggttcg tattcaagag acccaagctg agcttcctcg agggagtatc      660

ccccgcagtt tagaagtaat tttaagggct gaagctgtgg aatcagctca agctggtgac      720

aagtgtgact ttacagggac actgattgtt gtgcctgacg tctccaagct tagcacacca      780

ggagcacgtg cagaaactaa ttcccgtgtc agtggtgttg atggatatga gacagaaggc      840

attcgaggac tccgggccct tggtgttagg gacctttctt ataggctggt ctttcttgcc      900

tgctgtgttg cgccaaccaa cccaaggttt ggggggaaag agctcagaga tgaggaacag      960

acagctgaga gcattaagaa ccaaatgact gtgaaagaat gggagaaagt gtttgagatg     1020

agtcaagata aaaatctata ccacaatctt tgtaccagcc tgttccctac tatacatggc     1080

aatgatgaag taaaacgggg tgtcctgctg atgctctttg gtggcgttcc aaagacaaca     1140

ggagaaggga cctctcttcg aggggacata aatgtttgca ttgttggtga cccaagtaca     1200

gctaagagcc aatttctcaa gcacgtggag gagttcagcc ccagagctgt ctacaccagt     1260

ggtaaagcgt ccagtgctgc tggcttaaca gcagctgttg tgagagatga agaatctcat     1320

gagtttgtca ttgaggctgg agctttgatg ttggctgata atggtgtgtg ttgtattgat     1380

gaatttgata agatggacgt gcgggatcaa gttgctattc atgaagctat ggaacagcag     1440

accatatcca tcactaaagc aggagtgaag gctactctga acgcccggac gtccattttg     1500

gcagcagcaa acccaatcag tggacactat gacagatcaa aatcattgaa acagaatata     1560

aatttgtcag ctcccatcat gtcccgattc gatctcttct ttatccttgt ggatgaatgt     1620

aatgaggtta cagattatgc cattgccagg cgcatagtag atttgcattc aagaattgag     1680

gaatcaattg atcgtgtcta ttccctcgat gatatcagaa gatatcttct ctttgcaaga     1740

cagtttaaac ccaagatttc caaagagtca gaggacttca ttgtggagca atataaacat     1800

ctccgccaga gagatggttc tggagtgacc aagtcttcat ggaggattac agtgcgacag     1860

cttgagagca tgattcgtct ctctgaagct atggctcgga tgcactgctg tgatgaggtc     1920

caacctaaac atgtgaagga agctttccgg ttactgaata aatcaatcat ccgtgtggaa     1980

acacctgatg tcaatctaga tcaagaggaa gagatccaga tggaggtaga tgagggtgct     2040

ggtggcatca atggtcatgc tgacagccct gctcctgtga acgggatcaa tggctacaat     2100

gaagacataa atcaagagtc tgctcccaaa gcctccttaa ggctgggctt ctctgagtac     2160

tgccgaatct ctaaccttat tgtgcttcac ctcagaaagg tggaagaaga agaggacgag     2220

tcagcattaa agaggagcga gcttgttaac tggtacttga aggaaatcga atcagagata     2280

gactctgaag aagaacttat aaataaaaaa agaatcatag agaaagttat tcatcgactc     2340

acacactatg atcatgttct aattgagctc acccaggctg gattgaaagg ctccacagag     2400

ggaagtgaga gctatgaaga agatccctac ttggtagtta accctaacta cttgctcgaa     2460

gattga                                                                2466


<210>  130
<211>  821
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Asp Leu Ala Ala Ala Ala Glu Pro Gly Ala Gly Ser Gln His Leu 
1               5                   10                  15      


Glu Val Arg Asp Glu Val Ala Glu Lys Cys Gln Lys Leu Phe Leu Asp 
            20                  25                  30          


Phe Leu Glu Glu Phe Gln Ser Ser Asp Gly Glu Ile Lys Tyr Leu Gln 
        35                  40                  45              


Leu Ala Glu Glu Leu Ile Arg Pro Glu Arg Asn Thr Leu Val Val Ser 
    50                  55                  60                  


Phe Val Asp Leu Glu Gln Phe Asn Gln Gln Leu Ser Thr Thr Ile Gln 
65                  70                  75                  80  


Glu Glu Phe Tyr Arg Val Tyr Pro Tyr Leu Cys Arg Ala Leu Lys Thr 
                85                  90                  95      


Phe Val Lys Asp Arg Lys Glu Ile Pro Leu Ala Lys Asp Phe Tyr Val 
            100                 105                 110         


Ala Phe Gln Asp Leu Pro Thr Arg His Lys Ile Arg Glu Leu Thr Ser 
        115                 120                 125             


Ser Arg Ile Gly Leu Leu Thr Arg Ile Ser Gly Gln Val Val Arg Thr 
    130                 135                 140                 


His Pro Val His Pro Glu Leu Val Ser Gly Thr Phe Leu Cys Leu Asp 
145                 150                 155                 160 


Cys Gln Thr Val Ile Arg Asp Val Glu Gln Gln Phe Lys Tyr Thr Gln 
                165                 170                 175     


Pro Asn Ile Cys Arg Asn Pro Val Cys Ala Asn Arg Arg Arg Phe Leu 
            180                 185                 190         


Leu Asp Thr Asn Lys Ser Arg Phe Val Asp Phe Gln Lys Val Arg Ile 
        195                 200                 205             


Gln Glu Thr Gln Ala Glu Leu Pro Arg Gly Ser Ile Pro Arg Ser Leu 
    210                 215                 220                 


Glu Val Ile Leu Arg Ala Glu Ala Val Glu Ser Ala Gln Ala Gly Asp 
225                 230                 235                 240 


Lys Cys Asp Phe Thr Gly Thr Leu Ile Val Val Pro Asp Val Ser Lys 
                245                 250                 255     


Leu Ser Thr Pro Gly Ala Arg Ala Glu Thr Asn Ser Arg Val Ser Gly 
            260                 265                 270         


Val Asp Gly Tyr Glu Thr Glu Gly Ile Arg Gly Leu Arg Ala Leu Gly 
        275                 280                 285             


Val Arg Asp Leu Ser Tyr Arg Leu Val Phe Leu Ala Cys Cys Val Ala 
    290                 295                 300                 


Pro Thr Asn Pro Arg Phe Gly Gly Lys Glu Leu Arg Asp Glu Glu Gln 
305                 310                 315                 320 


Thr Ala Glu Ser Ile Lys Asn Gln Met Thr Val Lys Glu Trp Glu Lys 
                325                 330                 335     


Val Phe Glu Met Ser Gln Asp Lys Asn Leu Tyr His Asn Leu Cys Thr 
            340                 345                 350         


Ser Leu Phe Pro Thr Ile His Gly Asn Asp Glu Val Lys Arg Gly Val 
        355                 360                 365             


Leu Leu Met Leu Phe Gly Gly Val Pro Lys Thr Thr Gly Glu Gly Thr 
    370                 375                 380                 


Ser Leu Arg Gly Asp Ile Asn Val Cys Ile Val Gly Asp Pro Ser Thr 
385                 390                 395                 400 


Ala Lys Ser Gln Phe Leu Lys His Val Glu Glu Phe Ser Pro Arg Ala 
                405                 410                 415     


Val Tyr Thr Ser Gly Lys Ala Ser Ser Ala Ala Gly Leu Thr Ala Ala 
            420                 425                 430         


Val Val Arg Asp Glu Glu Ser His Glu Phe Val Ile Glu Ala Gly Ala 
        435                 440                 445             


Leu Met Leu Ala Asp Asn Gly Val Cys Cys Ile Asp Glu Phe Asp Lys 
    450                 455                 460                 


Met Asp Val Arg Asp Gln Val Ala Ile His Glu Ala Met Glu Gln Gln 
465                 470                 475                 480 


Thr Ile Ser Ile Thr Lys Ala Gly Val Lys Ala Thr Leu Asn Ala Arg 
                485                 490                 495     


Thr Ser Ile Leu Ala Ala Ala Asn Pro Ile Ser Gly His Tyr Asp Arg 
            500                 505                 510         


Ser Lys Ser Leu Lys Gln Asn Ile Asn Leu Ser Ala Pro Ile Met Ser 
        515                 520                 525             


Arg Phe Asp Leu Phe Phe Ile Leu Val Asp Glu Cys Asn Glu Val Thr 
    530                 535                 540                 


Asp Tyr Ala Ile Ala Arg Arg Ile Val Asp Leu His Ser Arg Ile Glu 
545                 550                 555                 560 


Glu Ser Ile Asp Arg Val Tyr Ser Leu Asp Asp Ile Arg Arg Tyr Leu 
                565                 570                 575     


Leu Phe Ala Arg Gln Phe Lys Pro Lys Ile Ser Lys Glu Ser Glu Asp 
            580                 585                 590         


Phe Ile Val Glu Gln Tyr Lys His Leu Arg Gln Arg Asp Gly Ser Gly 
        595                 600                 605             


Val Thr Lys Ser Ser Trp Arg Ile Thr Val Arg Gln Leu Glu Ser Met 
    610                 615                 620                 


Ile Arg Leu Ser Glu Ala Met Ala Arg Met His Cys Cys Asp Glu Val 
625                 630                 635                 640 


Gln Pro Lys His Val Lys Glu Ala Phe Arg Leu Leu Asn Lys Ser Ile 
                645                 650                 655     


Ile Arg Val Glu Thr Pro Asp Val Asn Leu Asp Gln Glu Glu Glu Ile 
            660                 665                 670         


Gln Met Glu Val Asp Glu Gly Ala Gly Gly Ile Asn Gly His Ala Asp 
        675                 680                 685             


Ser Pro Ala Pro Val Asn Gly Ile Asn Gly Tyr Asn Glu Asp Ile Asn 
    690                 695                 700                 


Gln Glu Ser Ala Pro Lys Ala Ser Leu Arg Leu Gly Phe Ser Glu Tyr 
705                 710                 715                 720 


Cys Arg Ile Ser Asn Leu Ile Val Leu His Leu Arg Lys Val Glu Glu 
                725                 730                 735     


Glu Glu Asp Glu Ser Ala Leu Lys Arg Ser Glu Leu Val Asn Trp Tyr 
            740                 745                 750         


Leu Lys Glu Ile Glu Ser Glu Ile Asp Ser Glu Glu Glu Leu Ile Asn 
        755                 760                 765             


Lys Lys Arg Ile Ile Glu Lys Val Ile His Arg Leu Thr His Tyr Asp 
    770                 775                 780                 


His Val Leu Ile Glu Leu Thr Gln Ala Gly Leu Lys Gly Ser Thr Glu 
785                 790                 795                 800 


Gly Ser Glu Ser Tyr Glu Glu Asp Pro Tyr Leu Val Val Asn Pro Asn 
                805                 810                 815     


Tyr Leu Leu Glu Asp 
            820     


<210>  131
<211>  882
<212>  DNA
<213>  Homo sapiens

<400>  131
atggcgactt tttctggccc ggctgggcca atcctgtcgc ttaatccgca ggaagatgtc       60

gagtttcaaa aggaggtggc gcaggttcgc aagcgcataa cccagcgaaa aaaacaagaa      120

caacttactc ctggagtagt ctatgtgcgc cacctaccta acctacttga cgaaacccag      180

atcttttcat atttctccca gtttggcact gtgacacggt tcaggctgtc cagaagtaaa      240

aggactggaa atagcaaagg ctatgcattt gtggagtttg agtctgagga tgttgccaaa      300

atagttgctg aaacaatgaa caactacctg tttggtgaaa gactcttgga gtgtcatttt      360

atgccacctg aaaaagtaca taaagaactc tttaaagact ggaatattcc atttaagcag      420

ccatcatatc catcagtgaa acggtataat cggaatcgga cactaacaca aaagctacgg      480

atggaggagc gatttaaaaa gaaagaaaga ttactcagga agaaattagc taaaaaagga      540

attgactatg attttccttc tttgatttta cagaaaacgg aaagtatttc aaaaactaat      600

cgtcagacgt ctacaaaagg ccaggtttta cgtaagaaga agaaaaaagt ttcaggtact      660

cttgacactc ctgagaagac tgtggatagc cagggcccca caccagtttg tacaccaaca      720

tttttggaga ggcgaaaatc tcaagtggct gaactgaatg atgatgataa agatgatgaa      780

atagttttca aacagcccat atcctgtgta aaagaagaaa tacaagagac tcaaacacct      840

acacattcac ggaaaaaaag acgaagaagc agcaatcagt ga                         882


<210>  132
<211>  293
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Ala Thr Phe Ser Gly Pro Ala Gly Pro Ile Leu Ser Leu Asn Pro 
1               5                   10                  15      


Gln Glu Asp Val Glu Phe Gln Lys Glu Val Ala Gln Val Arg Lys Arg 
            20                  25                  30          


Ile Thr Gln Arg Lys Lys Gln Glu Gln Leu Thr Pro Gly Val Val Tyr 
        35                  40                  45              


Val Arg His Leu Pro Asn Leu Leu Asp Glu Thr Gln Ile Phe Ser Tyr 
    50                  55                  60                  


Phe Ser Gln Phe Gly Thr Val Thr Arg Phe Arg Leu Ser Arg Ser Lys 
65                  70                  75                  80  


Arg Thr Gly Asn Ser Lys Gly Tyr Ala Phe Val Glu Phe Glu Ser Glu 
                85                  90                  95      


Asp Val Ala Lys Ile Val Ala Glu Thr Met Asn Asn Tyr Leu Phe Gly 
            100                 105                 110         


Glu Arg Leu Leu Glu Cys His Phe Met Pro Pro Glu Lys Val His Lys 
        115                 120                 125             


Glu Leu Phe Lys Asp Trp Asn Ile Pro Phe Lys Gln Pro Ser Tyr Pro 
    130                 135                 140                 


Ser Val Lys Arg Tyr Asn Arg Asn Arg Thr Leu Thr Gln Lys Leu Arg 
145                 150                 155                 160 


Met Glu Glu Arg Phe Lys Lys Lys Glu Arg Leu Leu Arg Lys Lys Leu 
                165                 170                 175     


Ala Lys Lys Gly Ile Asp Tyr Asp Phe Pro Ser Leu Ile Leu Gln Lys 
            180                 185                 190         


Thr Glu Ser Ile Ser Lys Thr Asn Arg Gln Thr Ser Thr Lys Gly Gln 
        195                 200                 205             


Val Leu Arg Lys Lys Lys Lys Lys Val Ser Gly Thr Leu Asp Thr Pro 
    210                 215                 220                 


Glu Lys Thr Val Asp Ser Gln Gly Pro Thr Pro Val Cys Thr Pro Thr 
225                 230                 235                 240 


Phe Leu Glu Arg Arg Lys Ser Gln Val Ala Glu Leu Asn Asp Asp Asp 
                245                 250                 255     


Lys Asp Asp Glu Ile Val Phe Lys Gln Pro Ile Ser Cys Val Lys Glu 
            260                 265                 270         


Glu Ile Gln Glu Thr Gln Thr Pro Thr His Ser Arg Lys Lys Arg Arg 
        275                 280                 285             


Arg Ser Ser Asn Gln 
    290             


<210>  133
<211>  1173
<212>  DNA
<213>  Homo sapiens

<400>  133
atgggccgcg gggcccgtgt cccctcggag gccccggggg caggcgtcga gcgccgctgg       60

cttggagccg cgctggtcgc cctgtgcctc ctccccgcgc tggtgctgct ggcccggctg      120

ggggccccgg cggtgccggc ctggagcgca gcgcagggag acgtcgctgc gctgggcctc      180

tcggcggtcc cccccacccg ggtcccgggc ccactggccc cccgcagacg ccgctacacg      240

ctgactccag ccaggctgcg ctgggaccac ttcaacctca cctacaggat cctctccttc      300

ccgcggaacc tgctgagccc gcgggagacg cggcgggccc tagctgccgc cttccgcatg      360

tggagcgacg tgtccccctt cagcttccgc gaggtggccc ccgagcagcc cagcgacctc      420

cggataggct tctacccgat caaccacacg gactgcctgg tctccgcgct gcaccactgc      480

ttcgacggcc ccacggggga gctggcccac gccttcttcc ccccgcacgg cggcatccac      540

ttcgacgaca gcgagtactg ggtcctgggc cccacgcgct acagctggaa gaaaggcgtg      600

tggctcacgg acctggtgca cgtggcggcc cacgagatcg gccacgcgct gggcctgatg      660

cactcacaac acggccgggc gctcatgcac ctgaacgcca cgctgcgcgg ctggaaggcg      720

ttgtcccagg acgagctgtg ggggctgcac cggctctacg gatgcctcga caggctgttc      780

gtgtgcgcgt cctgggcgcg gaggggcttc tgcgacgctc gccggcggct catgaagagg      840

ctctgcccca gcagctgcga cttctgctac gaattcccct tccccacggt ggccaccacc      900

ccaccgcccc ccaggaccaa aaccaggctg gtgcccgagg gcaggaacgt gaccttccgc      960

tgcggccaga agatcctcca caagaaaggg aaagtgtact ggtacaagga ccaggagccc     1020

ctggagttct cctaccccgg ctacctggcc ctgggcgagg cgcacctgag catcatcgcc     1080

aacgccgtca atgagggcac ctacacctgc gtggtgcgcc gccagcagcg cgtgctgacc     1140

acctactcct ggcgagtccg tgtgcggggc tga                                  1173


<210>  134
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Gly Arg Gly Ala Arg Val Pro Ser Glu Ala Pro Gly Ala Gly Val 
1               5                   10                  15      


Glu Arg Arg Trp Leu Gly Ala Ala Leu Val Ala Leu Cys Leu Leu Pro 
            20                  25                  30          


Ala Leu Val Leu Leu Ala Arg Leu Gly Ala Pro Ala Val Pro Ala Trp 
        35                  40                  45              


Ser Ala Ala Gln Gly Asp Val Ala Ala Leu Gly Leu Ser Ala Val Pro 
    50                  55                  60                  


Pro Thr Arg Val Pro Gly Pro Leu Ala Pro Arg Arg Arg Arg Tyr Thr 
65                  70                  75                  80  


Leu Thr Pro Ala Arg Leu Arg Trp Asp His Phe Asn Leu Thr Tyr Arg 
                85                  90                  95      


Ile Leu Ser Phe Pro Arg Asn Leu Leu Ser Pro Arg Glu Thr Arg Arg 
            100                 105                 110         


Ala Leu Ala Ala Ala Phe Arg Met Trp Ser Asp Val Ser Pro Phe Ser 
        115                 120                 125             


Phe Arg Glu Val Ala Pro Glu Gln Pro Ser Asp Leu Arg Ile Gly Phe 
    130                 135                 140                 


Tyr Pro Ile Asn His Thr Asp Cys Leu Val Ser Ala Leu His His Cys 
145                 150                 155                 160 


Phe Asp Gly Pro Thr Gly Glu Leu Ala His Ala Phe Phe Pro Pro His 
                165                 170                 175     


Gly Gly Ile His Phe Asp Asp Ser Glu Tyr Trp Val Leu Gly Pro Thr 
            180                 185                 190         


Arg Tyr Ser Trp Lys Lys Gly Val Trp Leu Thr Asp Leu Val His Val 
        195                 200                 205             


Ala Ala His Glu Ile Gly His Ala Leu Gly Leu Met His Ser Gln His 
    210                 215                 220                 


Gly Arg Ala Leu Met His Leu Asn Ala Thr Leu Arg Gly Trp Lys Ala 
225                 230                 235                 240 


Leu Ser Gln Asp Glu Leu Trp Gly Leu His Arg Leu Tyr Gly Cys Leu 
                245                 250                 255     


Asp Arg Leu Phe Val Cys Ala Ser Trp Ala Arg Arg Gly Phe Cys Asp 
            260                 265                 270         


Ala Arg Arg Arg Leu Met Lys Arg Leu Cys Pro Ser Ser Cys Asp Phe 
        275                 280                 285             


Cys Tyr Glu Phe Pro Phe Pro Thr Val Ala Thr Thr Pro Pro Pro Pro 
    290                 295                 300                 


Arg Thr Lys Thr Arg Leu Val Pro Glu Gly Arg Asn Val Thr Phe Arg 
305                 310                 315                 320 


Cys Gly Gln Lys Ile Leu His Lys Lys Gly Lys Val Tyr Trp Tyr Lys 
                325                 330                 335     


Asp Gln Glu Pro Leu Glu Phe Ser Tyr Pro Gly Tyr Leu Ala Leu Gly 
            340                 345                 350         


Glu Ala His Leu Ser Ile Ile Ala Asn Ala Val Asn Glu Gly Thr Tyr 
        355                 360                 365             


Thr Cys Val Val Arg Arg Gln Gln Arg Val Leu Thr Thr Tyr Ser Trp 
    370                 375                 380                 


Arg Val Arg Val Arg Gly 
385                 390 


<210>  135
<211>  2805
<212>  DNA
<213>  Homo sapiens

<400>  135
atggcggtgc agccgaagga gacgctgcag ttggagagcg cggccgaggt cggcttcgtg       60

cgcttctttc agggcatgcc ggagaagccg accaccacag tgcgcctttt cgaccggggc      120

gacttctata cggcgcacgg cgaggacgcg ctgctggccg cccgggaggt gttcaagacc      180

cagggggtga tcaagtacat ggggccggca ggagcaaaga atctgcagag tgttgtgctt      240

agtaaaatga attttgaatc ttttgtaaaa gatcttcttc tggttcgtca gtatagagtt      300

gaagtttata agaatagagc tggaaataag gcatccaagg agaatgattg gtatttggca      360

tataaggctt ctcctggcaa tctctctcag tttgaagaca ttctctttgg taacaatgat      420

atgtcagctt ccattggtgt tgtgggtgtt aaaatgtccg cagttgatgg ccagagacag      480

gttggagttg ggtatgtgga ttccatacag aggaaactag gactgtgtga attccctgat      540

aatgatcagt tctccaatct tgaggctctc ctcatccaga ttggaccaaa ggaatgtgtt      600

ttacccggag gagagactgc tggagacatg gggaaactga gacagataat tcaaagagga      660

ggaattctga tcacagaaag aaaaaaagct gacttttcca caaaagacat ttatcaggac      720

ctcaaccggt tgttgaaagg caaaaaggga gagcagatga atagtgctgt attgccagaa      780

atggagaatc aggttgcagt ttcatcactg tctgcggtaa tcaagttttt agaactctta      840

tcagatgatt ccaactttgg acagtttgaa ctgactactt ttgacttcag ccagtatatg      900

aaattggata ttgcagcagt cagagccctt aacctttttc agggttctgt tgaagatacc      960

actggctctc agtctctggc tgccttgctg aataagtgta aaacccctca aggacaaaga     1020

cttgttaacc agtggattaa gcagcctctc atggataaga acagaataga ggagagattg     1080

aatttagtgg aagcttttgt agaagatgca gaattgaggc agactttaca agaagattta     1140

cttcgtcgat tcccagatct taaccgactt gccaagaagt ttcaaagaca agcagcaaac     1200

ttacaagatt gttaccgact ctatcagggt ataaatcaac tacctaatgt tatacaggct     1260

ctggaaaaac atgaaggaaa acaccagaaa ttattgttgg cagtttttgt gactcctctt     1320

actgatcttc gttctgactt ctccaagttt caggaaatga tagaaacaac tttagatatg     1380

gatcaggtgg aaaaccatga attccttgta aaaccttcat ttgatcctaa tctcagtgaa     1440

ttaagagaaa taatgaatga cttggaaaag aagatgcagt caacattaat aagtgcagcc     1500

agagatcttg gcttggaccc tggcaaacag attaaactgg attccagtgc acagtttgga     1560

tattactttc gtgtaacctg taaggaagaa aaagtccttc gtaacaataa aaactttagt     1620

actgtagata tccagaagaa tggtgttaaa tttaccaaca gcaaattgac ttctttaaat     1680

gaagagtata ccaaaaataa aacagaatat gaagaagccc aggatgccat tgttaaagaa     1740

attgtcaata tttcttcagg ctatgtagaa ccaatgcaga cactcaatga tgtgttagct     1800

cagctagatg ctgttgtcag ctttgctcac gtgtcaaatg gagcacctgt tccatatgta     1860

cgaccagcca ttttggagaa aggacaagga agaattatat taaaagcatc caggcatgct     1920

tgtgttgaag ttcaagatga aattgcattt attcctaatg acgtatactt tgaaaaagat     1980

aaacagatgt tccacatcat tactggcccc aatatgggag gtaaatcaac atatattcga     2040

caaactgggg tgatagtact catggcccaa attgggtgtt ttgtgccatg tgagtcagca     2100

gaagtgtcca ttgtggactg catcttagcc cgagtagggg ctggtgacag tcaattgaaa     2160

ggagtctcca cgttcatggc tgaaatgttg gaaactgctt ctatcctcag gtctgcaacc     2220

aaagattcat taataatcat agatgaattg ggaagaggaa cttctaccta cgatggattt     2280

gggttagcat gggctatatc agaatacatt gcaacaaaga ttggtgcttt ttgcatgttt     2340

gcaacccatt ttcatgaact tactgccttg gccaatcaga taccaactgt taataatcta     2400

catgtcacag cactcaccac tgaagagacc ttaactatgc tttatcaggt gaagaaaggt     2460

gtctgtgatc aaagttttgg gattcatgtt gcagagcttg ctaatttccc taagcatgta     2520

atagagtgtg ctaaacagaa agccctggaa cttgaggagt ttcagtatat tggagaatcg     2580

caaggatatg atatcatgga accagcagca aagaagtgct atctggaaag agagcaaggt     2640

gaaaaaatta ttcaggagtt cctgtccaag gtgaaacaaa tgccctttac tgaaatgtca     2700

gaagaaaaca tcacaataaa gttaaaacag ctaaaagctg aagtaatagc aaagaataat     2760

agctttgtaa atgaaatcat ttcacgaata aaagttacta cgtga                     2805


<210>  136
<211>  934
<212>  PRT
<213>  Homo sapiens

<400>  136

Met Ala Val Gln Pro Lys Glu Thr Leu Gln Leu Glu Ser Ala Ala Glu 
1               5                   10                  15      


Val Gly Phe Val Arg Phe Phe Gln Gly Met Pro Glu Lys Pro Thr Thr 
            20                  25                  30          


Thr Val Arg Leu Phe Asp Arg Gly Asp Phe Tyr Thr Ala His Gly Glu 
        35                  40                  45              


Asp Ala Leu Leu Ala Ala Arg Glu Val Phe Lys Thr Gln Gly Val Ile 
    50                  55                  60                  


Lys Tyr Met Gly Pro Ala Gly Ala Lys Asn Leu Gln Ser Val Val Leu 
65                  70                  75                  80  


Ser Lys Met Asn Phe Glu Ser Phe Val Lys Asp Leu Leu Leu Val Arg 
                85                  90                  95      


Gln Tyr Arg Val Glu Val Tyr Lys Asn Arg Ala Gly Asn Lys Ala Ser 
            100                 105                 110         


Lys Glu Asn Asp Trp Tyr Leu Ala Tyr Lys Ala Ser Pro Gly Asn Leu 
        115                 120                 125             


Ser Gln Phe Glu Asp Ile Leu Phe Gly Asn Asn Asp Met Ser Ala Ser 
    130                 135                 140                 


Ile Gly Val Val Gly Val Lys Met Ser Ala Val Asp Gly Gln Arg Gln 
145                 150                 155                 160 


Val Gly Val Gly Tyr Val Asp Ser Ile Gln Arg Lys Leu Gly Leu Cys 
                165                 170                 175     


Glu Phe Pro Asp Asn Asp Gln Phe Ser Asn Leu Glu Ala Leu Leu Ile 
            180                 185                 190         


Gln Ile Gly Pro Lys Glu Cys Val Leu Pro Gly Gly Glu Thr Ala Gly 
        195                 200                 205             


Asp Met Gly Lys Leu Arg Gln Ile Ile Gln Arg Gly Gly Ile Leu Ile 
    210                 215                 220                 


Thr Glu Arg Lys Lys Ala Asp Phe Ser Thr Lys Asp Ile Tyr Gln Asp 
225                 230                 235                 240 


Leu Asn Arg Leu Leu Lys Gly Lys Lys Gly Glu Gln Met Asn Ser Ala 
                245                 250                 255     


Val Leu Pro Glu Met Glu Asn Gln Val Ala Val Ser Ser Leu Ser Ala 
            260                 265                 270         


Val Ile Lys Phe Leu Glu Leu Leu Ser Asp Asp Ser Asn Phe Gly Gln 
        275                 280                 285             


Phe Glu Leu Thr Thr Phe Asp Phe Ser Gln Tyr Met Lys Leu Asp Ile 
    290                 295                 300                 


Ala Ala Val Arg Ala Leu Asn Leu Phe Gln Gly Ser Val Glu Asp Thr 
305                 310                 315                 320 


Thr Gly Ser Gln Ser Leu Ala Ala Leu Leu Asn Lys Cys Lys Thr Pro 
                325                 330                 335     


Gln Gly Gln Arg Leu Val Asn Gln Trp Ile Lys Gln Pro Leu Met Asp 
            340                 345                 350         


Lys Asn Arg Ile Glu Glu Arg Leu Asn Leu Val Glu Ala Phe Val Glu 
        355                 360                 365             


Asp Ala Glu Leu Arg Gln Thr Leu Gln Glu Asp Leu Leu Arg Arg Phe 
    370                 375                 380                 


Pro Asp Leu Asn Arg Leu Ala Lys Lys Phe Gln Arg Gln Ala Ala Asn 
385                 390                 395                 400 


Leu Gln Asp Cys Tyr Arg Leu Tyr Gln Gly Ile Asn Gln Leu Pro Asn 
                405                 410                 415     


Val Ile Gln Ala Leu Glu Lys His Glu Gly Lys His Gln Lys Leu Leu 
            420                 425                 430         


Leu Ala Val Phe Val Thr Pro Leu Thr Asp Leu Arg Ser Asp Phe Ser 
        435                 440                 445             


Lys Phe Gln Glu Met Ile Glu Thr Thr Leu Asp Met Asp Gln Val Glu 
    450                 455                 460                 


Asn His Glu Phe Leu Val Lys Pro Ser Phe Asp Pro Asn Leu Ser Glu 
465                 470                 475                 480 


Leu Arg Glu Ile Met Asn Asp Leu Glu Lys Lys Met Gln Ser Thr Leu 
                485                 490                 495     


Ile Ser Ala Ala Arg Asp Leu Gly Leu Asp Pro Gly Lys Gln Ile Lys 
            500                 505                 510         


Leu Asp Ser Ser Ala Gln Phe Gly Tyr Tyr Phe Arg Val Thr Cys Lys 
        515                 520                 525             


Glu Glu Lys Val Leu Arg Asn Asn Lys Asn Phe Ser Thr Val Asp Ile 
    530                 535                 540                 


Gln Lys Asn Gly Val Lys Phe Thr Asn Ser Lys Leu Thr Ser Leu Asn 
545                 550                 555                 560 


Glu Glu Tyr Thr Lys Asn Lys Thr Glu Tyr Glu Glu Ala Gln Asp Ala 
                565                 570                 575     


Ile Val Lys Glu Ile Val Asn Ile Ser Ser Gly Tyr Val Glu Pro Met 
            580                 585                 590         


Gln Thr Leu Asn Asp Val Leu Ala Gln Leu Asp Ala Val Val Ser Phe 
        595                 600                 605             


Ala His Val Ser Asn Gly Ala Pro Val Pro Tyr Val Arg Pro Ala Ile 
    610                 615                 620                 


Leu Glu Lys Gly Gln Gly Arg Ile Ile Leu Lys Ala Ser Arg His Ala 
625                 630                 635                 640 


Cys Val Glu Val Gln Asp Glu Ile Ala Phe Ile Pro Asn Asp Val Tyr 
                645                 650                 655     


Phe Glu Lys Asp Lys Gln Met Phe His Ile Ile Thr Gly Pro Asn Met 
            660                 665                 670         


Gly Gly Lys Ser Thr Tyr Ile Arg Gln Thr Gly Val Ile Val Leu Met 
        675                 680                 685             


Ala Gln Ile Gly Cys Phe Val Pro Cys Glu Ser Ala Glu Val Ser Ile 
    690                 695                 700                 


Val Asp Cys Ile Leu Ala Arg Val Gly Ala Gly Asp Ser Gln Leu Lys 
705                 710                 715                 720 


Gly Val Ser Thr Phe Met Ala Glu Met Leu Glu Thr Ala Ser Ile Leu 
                725                 730                 735     


Arg Ser Ala Thr Lys Asp Ser Leu Ile Ile Ile Asp Glu Leu Gly Arg 
            740                 745                 750         


Gly Thr Ser Thr Tyr Asp Gly Phe Gly Leu Ala Trp Ala Ile Ser Glu 
        755                 760                 765             


Tyr Ile Ala Thr Lys Ile Gly Ala Phe Cys Met Phe Ala Thr His Phe 
    770                 775                 780                 


His Glu Leu Thr Ala Leu Ala Asn Gln Ile Pro Thr Val Asn Asn Leu 
785                 790                 795                 800 


His Val Thr Ala Leu Thr Thr Glu Glu Thr Leu Thr Met Leu Tyr Gln 
                805                 810                 815     


Val Lys Lys Gly Val Cys Asp Gln Ser Phe Gly Ile His Val Ala Glu 
            820                 825                 830         


Leu Ala Asn Phe Pro Lys His Val Ile Glu Cys Ala Lys Gln Lys Ala 
        835                 840                 845             


Leu Glu Leu Glu Glu Phe Gln Tyr Ile Gly Glu Ser Gln Gly Tyr Asp 
    850                 855                 860                 


Ile Met Glu Pro Ala Ala Lys Lys Cys Tyr Leu Glu Arg Glu Gln Gly 
865                 870                 875                 880 


Glu Lys Ile Ile Gln Glu Phe Leu Ser Lys Val Lys Gln Met Pro Phe 
                885                 890                 895     


Thr Glu Met Ser Glu Glu Asn Ile Thr Ile Lys Leu Lys Gln Leu Lys 
            900                 905                 910         


Ala Glu Val Ile Ala Lys Asn Asn Ser Phe Val Asn Glu Ile Ile Ser 
        915                 920                 925             


Arg Ile Lys Val Thr Thr 
    930                 


<210>  137
<211>  503
<212>  DNA
<213>  Homo sapiens

<400>  137
cgggcaatgc tgtgagagcc attggaagac tgtcctctat ggcaatgatc tcagggctca       60

gtggcaggaa atcctcaaca gggtcaccaa ccagcccgct caatgcagaa aaactagaat      120

ctgaagaaga tgtgtcccaa gctttccttg aggctgttgc tgaggaaaag cctcatgtaa      180

aaccctattt ctctaagacc attcgcgatt tagaagttgt ggagggaagt gctgctagat      240

ttgactgcaa gattgaagga tacccagacc ccgaggttgt ctggttcaaa gatgaccagt      300

caatcaggga gtcccgccac ttccagatag actacgatga ggacgggaac tgctctttaa      360

ttattagtga tgtttgcggg gatgacgatg ccaagtacac ctgcaaggct gtcaacagtc      420

ttggagaagc cacctgcaca gcagagctca ttgtggaaac gatggaggaa ggtgaagggg      480

aaggggaaga ggaagaagag tga                                              503


<210>  138
<211>  166
<212>  PRT
<213>  Homo sapiens

<400>  138

Gly Asn Ala Val Arg Ala Ile Gly Arg Leu Ser Ser Met Ala Met Ile 
1               5                   10                  15      


Ser Gly Leu Ser Gly Arg Lys Ser Ser Thr Gly Ser Pro Thr Ser Pro 
            20                  25                  30          


Leu Asn Ala Glu Lys Leu Glu Ser Glu Glu Asp Val Ser Gln Ala Phe 
        35                  40                  45              


Leu Glu Ala Val Ala Glu Glu Lys Pro His Val Lys Pro Tyr Phe Ser 
    50                  55                  60                  


Lys Thr Ile Arg Asp Leu Glu Val Val Glu Gly Ser Ala Ala Arg Phe 
65                  70                  75                  80  


Asp Cys Lys Ile Glu Gly Tyr Pro Asp Pro Glu Val Val Trp Phe Lys 
                85                  90                  95      


Asp Asp Gln Ser Ile Arg Glu Ser Arg His Phe Gln Ile Asp Tyr Asp 
            100                 105                 110         


Glu Asp Gly Asn Cys Ser Leu Ile Ile Ser Asp Val Cys Gly Asp Asp 
        115                 120                 125             


Asp Ala Lys Tyr Thr Cys Lys Ala Val Asn Ser Leu Gly Glu Ala Thr 
    130                 135                 140                 


Cys Thr Ala Glu Leu Ile Val Glu Thr Met Glu Glu Gly Glu Gly Glu 
145                 150                 155                 160 


Gly Glu Glu Glu Glu Glu 
                165     


<210>  139
<211>  3858
<212>  DNA
<213>  Homo sapiens

<400>  139
atggaggatg gaaagcccgt ttgggcgcca caccctacag atggatttca gatgggcaat       60

attgtggata ttggccccga cagcttaaca attgaaccct tgaatcagaa aggcaagaca      120

tttttggctc tcataaacca agtgtttcct gcagaagagg acagtaaaaa agatgtggaa      180

gataactgtt cactaatgta tttaaatgaa gccacactgc tccataatat caaagttcga      240

tatagtaaag acagaattta tacatatgtc gccaacattc tgattgcagt gaatccatac      300

tttgacatac ctaaaatata ttcttcagaa gcaataaagt catatcaagg aaaatctctt      360

gggacaagac cacctcatgt ctttgcaatt gctgataaag cttttcgaga catgaaggtg      420

ctcaagatga gtcagtctat cattgtatct ggagaatcag gagccggcaa aacagaaaat      480

acaaaatttg ttctaagata cctgactgaa tcctatggaa caggtcaaga tattgatgac      540

agaattgttg aagctaaccc actcctagaa gcctttggaa atgcgaagac tgttcgcaac      600

aataatagca gtcgatttgg gaaatttgta gaaatacatt ttaatgaaaa gagctcagtt      660

gttggaggat ttgtttcaca ttatctccta gagaaatcta ggatctgtgt tcaaggcaaa      720

gaggaaagaa attatcatat cttttatagg ttgtgtgctg gtgcttctga agatattaga      780

gaaaaacttc atttgagttc accagataat tttcggtatt taaaccgagg ctgcactaga      840

tactttgcta acaaagaaac tgacaaacag attttacaga accgcaaaag tcctgagtac      900

cttaaggcag gttctatgaa agatcctctg ctagatgacc atggtgattt tattagaatg      960

tgcacggcta tgaaaaaaat tggtttggat gatgaagaaa agcttgatct cttccgggta     1020

gtagctggcg tcctgcacct tggaaatatt gattttgagg aagctggcag cacttcaggt     1080

ggttgtaatc tgaagaataa atctgctcag tctttggaat attgtgctga attactgggt     1140

ttggaccaag atgatcttcg agtaagtttg accacaagag tcatgctaac aacagcaggg     1200

ggcaccaaag gaacagttat aaaggtacct ctgaaagtgg agcaagcaaa caatgctcgt     1260

gatgccctgg caaagacagt gtatagccat ctttttgatc atgtggtaaa cagagtaaat     1320

cagtgttttc cttttgaaac atcatcctat tttattggag tcctagatat tgctggtttt     1380

gagtactttg agcataacag ttttgaacaa ttttgcatca actattgcaa tgaaaaactt     1440

caacaatttt ttaatgaaag gattctgaag gaggaacaag aactctatca aaaagaaggt     1500

ttaggtgtta atgaagtgca ttatgtggat aatcaggact gtatagattt aattgaagcc     1560

aaattagtgg gaatactgga tattttggat gaagaaaatc gccttcccca gccaagtgat     1620

caacacttta catctgcagt tcaccaaaag cacaaggatc attttcgact cactattccc     1680

agaaaatcta agctggcagt tcataggaat atcagagacg acgaaggctt cattatcagg     1740

cattttgcgg gggcagtgtg ctatgaaaca acccagtttg tggagaaaaa taatgatgct     1800

ttacatatgt ctcttgaatc cttaatatgt gaatccagag ataagtttat acgggaatta     1860

tttgaatcat ccacaaataa caacaaagat actaaacaaa aagcaggaaa acttagcttc     1920

atcagcgtgg gaaacaagtt taagacacag ttaaatttgc ttctggataa acttcgaagt     1980

actggagcaa gctttattcg ttgcatcaaa cctaacttaa agatgacaag ccaccacttt     2040

gaaggtgctc aaattctgtc tcagcttcag tgttcaggga tggtgtctgt tttggacttg     2100

atgcagggtg gttacccatc acgagcttca tttcatgaac tctacaacat gtacaaaaag     2160

tatatgccag ataaacttgc aagattggat ccaagactat tttgtaaggc tttgtttaaa     2220

gctttgggct taaatgaaaa tgactacaag tttgggttaa ccaaagtatt ttttagacct     2280

ggcaagtttg cagaatttga tcagatcatg aagtctgacc ctgaccactt agcagagttg     2340

gttaaaagag tcaatcactg gctcacatgc agtcgctgga agaaagttca gtggtgctca     2400

ctctcagtca tcaaattgaa aaacaaaata aaatatcgag ctgaagcctg cattaaaatg     2460

caaaaaacta ttcgaatgtg gctttgcaag aggagacaca aacctcgcat tgatggtctg     2520

gttaaggtgg gcacactgaa aaaacgactt gataaattta atgaggtagt cagtgtgttg     2580

aaagatggaa aacccgagat gaataaacag atcaagaatc tggaaatttc tattgatact     2640

ttgatggcca aaattaagtc cactatgatg acgcaggaac aaatccagaa agaatatgat     2700

gcactggtta aaagctcaga ggaactcctc agtgcattac agaaaaaaaa acagcaggaa     2760

gaggaagcag aaaggctgag gcgtattcaa gaagaaatgg aaaaggaaag aaaaagacgt     2820

gaagaagacg aaaaacgtcg aagaaaggaa gaggaggaaa ggcggatgaa acttgagatg     2880

gaagcaaaga gaaaacaaga agaagaagag agaaagaaaa gggaagatga tgaaaaacgc     2940

attcaagctg aagtggaggc acagctggcc cgacagaagg aggaggaatc ccaacagcaa     3000

gcagttctgg agcaggagcg cagggaccgg gagctggccc tgaggattgc ccagagtgaa     3060

gccgagctca tcagtgatga ggcccaggcc gacctggcgc tgcggagaaa tgatggaaca     3120

agacccaaaa tgacaccgga acaaatggcc aaagaaatgt cagaattttt gagtagaggt     3180

cctgctgtac tagccaccaa agcagctgct ggtactaaga aatatgatct tagtaaatgg     3240

aaatatgcag aactacgtga taccatcaat acttcttgtg atattgagct cctggcagct     3300

tgcagagaag aatttcatag gagactaaaa gtgtatcatg cttggaaatc taagaacaag     3360

aagagaaata ctgaaacaga gcaacgtgct ccaaagtctg ttactgatta tgattttgca     3420

ccatttttga acaattcacc tcagcaaaac ccagcagctc agattcctgc caggcagcgg     3480

gagattgaaa tgaaccgaca gcaacgcttc ttccgcatcc cattcatccg ccctgccgac     3540

cagtacaaag accctcagag taagaaaaaa ggctggtggt atgcccattt tgatggacca     3600

tggattgccc ggcaaatgga actccatcct gacaagccac ccatcctact tgtggctggt     3660

aaggacgaca tggagatgtg tgagctgaat cttgaggaga ctggcctgac tcggaagcgt     3720

ggtgctgaga tcttgccaag acagtttgaa gaaatctggg aacgctgtgg aggcatccag     3780

taccttcaga atgcgattga gagcagacag gctcggccca cctatgcaac agccatgctg     3840

cagagtctgt taaagtag                                                   3858


<210>  140
<211>  1285
<212>  PRT
<213>  Homo sapiens

<400>  140

Met Glu Asp Gly Lys Pro Val Trp Ala Pro His Pro Thr Asp Gly Phe 
1               5                   10                  15      


Gln Met Gly Asn Ile Val Asp Ile Gly Pro Asp Ser Leu Thr Ile Glu 
            20                  25                  30          


Pro Leu Asn Gln Lys Gly Lys Thr Phe Leu Ala Leu Ile Asn Gln Val 
        35                  40                  45              


Phe Pro Ala Glu Glu Asp Ser Lys Lys Asp Val Glu Asp Asn Cys Ser 
    50                  55                  60                  


Leu Met Tyr Leu Asn Glu Ala Thr Leu Leu His Asn Ile Lys Val Arg 
65                  70                  75                  80  


Tyr Ser Lys Asp Arg Ile Tyr Thr Tyr Val Ala Asn Ile Leu Ile Ala 
                85                  90                  95      


Val Asn Pro Tyr Phe Asp Ile Pro Lys Ile Tyr Ser Ser Glu Ala Ile 
            100                 105                 110         


Lys Ser Tyr Gln Gly Lys Ser Leu Gly Thr Arg Pro Pro His Val Phe 
        115                 120                 125             


Ala Ile Ala Asp Lys Ala Phe Arg Asp Met Lys Val Leu Lys Met Ser 
    130                 135                 140                 


Gln Ser Ile Ile Val Ser Gly Glu Ser Gly Ala Gly Lys Thr Glu Asn 
145                 150                 155                 160 


Thr Lys Phe Val Leu Arg Tyr Leu Thr Glu Ser Tyr Gly Thr Gly Gln 
                165                 170                 175     


Asp Ile Asp Asp Arg Ile Val Glu Ala Asn Pro Leu Leu Glu Ala Phe 
            180                 185                 190         


Gly Asn Ala Lys Thr Val Arg Asn Asn Asn Ser Ser Arg Phe Gly Lys 
        195                 200                 205             


Phe Val Glu Ile His Phe Asn Glu Lys Ser Ser Val Val Gly Gly Phe 
    210                 215                 220                 


Val Ser His Tyr Leu Leu Glu Lys Ser Arg Ile Cys Val Gln Gly Lys 
225                 230                 235                 240 


Glu Glu Arg Asn Tyr His Ile Phe Tyr Arg Leu Cys Ala Gly Ala Ser 
                245                 250                 255     


Glu Asp Ile Arg Glu Lys Leu His Leu Ser Ser Pro Asp Asn Phe Arg 
            260                 265                 270         


Tyr Leu Asn Arg Gly Cys Thr Arg Tyr Phe Ala Asn Lys Glu Thr Asp 
        275                 280                 285             


Lys Gln Ile Leu Gln Asn Arg Lys Ser Pro Glu Tyr Leu Lys Ala Gly 
    290                 295                 300                 


Ser Met Lys Asp Pro Leu Leu Asp Asp His Gly Asp Phe Ile Arg Met 
305                 310                 315                 320 


Cys Thr Ala Met Lys Lys Ile Gly Leu Asp Asp Glu Glu Lys Leu Asp 
                325                 330                 335     


Leu Phe Arg Val Val Ala Gly Val Leu His Leu Gly Asn Ile Asp Phe 
            340                 345                 350         


Glu Glu Ala Gly Ser Thr Ser Gly Gly Cys Asn Leu Lys Asn Lys Ser 
        355                 360                 365             


Ala Gln Ser Leu Glu Tyr Cys Ala Glu Leu Leu Gly Leu Asp Gln Asp 
    370                 375                 380                 


Asp Leu Arg Val Ser Leu Thr Thr Arg Val Met Leu Thr Thr Ala Gly 
385                 390                 395                 400 


Gly Thr Lys Gly Thr Val Ile Lys Val Pro Leu Lys Val Glu Gln Ala 
                405                 410                 415     


Asn Asn Ala Arg Asp Ala Leu Ala Lys Thr Val Tyr Ser His Leu Phe 
            420                 425                 430         


Asp His Val Val Asn Arg Val Asn Gln Cys Phe Pro Phe Glu Thr Ser 
        435                 440                 445             


Ser Tyr Phe Ile Gly Val Leu Asp Ile Ala Gly Phe Glu Tyr Phe Glu 
    450                 455                 460                 


His Asn Ser Phe Glu Gln Phe Cys Ile Asn Tyr Cys Asn Glu Lys Leu 
465                 470                 475                 480 


Gln Gln Phe Phe Asn Glu Arg Ile Leu Lys Glu Glu Gln Glu Leu Tyr 
                485                 490                 495     


Gln Lys Glu Gly Leu Gly Val Asn Glu Val His Tyr Val Asp Asn Gln 
            500                 505                 510         


Asp Cys Ile Asp Leu Ile Glu Ala Lys Leu Val Gly Ile Leu Asp Ile 
        515                 520                 525             


Leu Asp Glu Glu Asn Arg Leu Pro Gln Pro Ser Asp Gln His Phe Thr 
    530                 535                 540                 


Ser Ala Val His Gln Lys His Lys Asp His Phe Arg Leu Thr Ile Pro 
545                 550                 555                 560 


Arg Lys Ser Lys Leu Ala Val His Arg Asn Ile Arg Asp Asp Glu Gly 
                565                 570                 575     


Phe Ile Ile Arg His Phe Ala Gly Ala Val Cys Tyr Glu Thr Thr Gln 
            580                 585                 590         


Phe Val Glu Lys Asn Asn Asp Ala Leu His Met Ser Leu Glu Ser Leu 
        595                 600                 605             


Ile Cys Glu Ser Arg Asp Lys Phe Ile Arg Glu Leu Phe Glu Ser Ser 
    610                 615                 620                 


Thr Asn Asn Asn Lys Asp Thr Lys Gln Lys Ala Gly Lys Leu Ser Phe 
625                 630                 635                 640 


Ile Ser Val Gly Asn Lys Phe Lys Thr Gln Leu Asn Leu Leu Leu Asp 
                645                 650                 655     


Lys Leu Arg Ser Thr Gly Ala Ser Phe Ile Arg Cys Ile Lys Pro Asn 
            660                 665                 670         


Leu Lys Met Thr Ser His His Phe Glu Gly Ala Gln Ile Leu Ser Gln 
        675                 680                 685             


Leu Gln Cys Ser Gly Met Val Ser Val Leu Asp Leu Met Gln Gly Gly 
    690                 695                 700                 


Tyr Pro Ser Arg Ala Ser Phe His Glu Leu Tyr Asn Met Tyr Lys Lys 
705                 710                 715                 720 


Tyr Met Pro Asp Lys Leu Ala Arg Leu Asp Pro Arg Leu Phe Cys Lys 
                725                 730                 735     


Ala Leu Phe Lys Ala Leu Gly Leu Asn Glu Asn Asp Tyr Lys Phe Gly 
            740                 745                 750         


Leu Thr Lys Val Phe Phe Arg Pro Gly Lys Phe Ala Glu Phe Asp Gln 
        755                 760                 765             


Ile Met Lys Ser Asp Pro Asp His Leu Ala Glu Leu Val Lys Arg Val 
    770                 775                 780                 


Asn His Trp Leu Thr Cys Ser Arg Trp Lys Lys Val Gln Trp Cys Ser 
785                 790                 795                 800 


Leu Ser Val Ile Lys Leu Lys Asn Lys Ile Lys Tyr Arg Ala Glu Ala 
                805                 810                 815     


Cys Ile Lys Met Gln Lys Thr Ile Arg Met Trp Leu Cys Lys Arg Arg 
            820                 825                 830         


His Lys Pro Arg Ile Asp Gly Leu Val Lys Val Gly Thr Leu Lys Lys 
        835                 840                 845             


Arg Leu Asp Lys Phe Asn Glu Val Val Ser Val Leu Lys Asp Gly Lys 
    850                 855                 860                 


Pro Glu Met Asn Lys Gln Ile Lys Asn Leu Glu Ile Ser Ile Asp Thr 
865                 870                 875                 880 


Leu Met Ala Lys Ile Lys Ser Thr Met Met Thr Gln Glu Gln Ile Gln 
                885                 890                 895     


Lys Glu Tyr Asp Ala Leu Val Lys Ser Ser Glu Glu Leu Leu Ser Ala 
            900                 905                 910         


Leu Gln Lys Lys Lys Gln Gln Glu Glu Glu Ala Glu Arg Leu Arg Arg 
        915                 920                 925             


Ile Gln Glu Glu Met Glu Lys Glu Arg Lys Arg Arg Glu Glu Asp Glu 
    930                 935                 940                 


Lys Arg Arg Arg Lys Glu Glu Glu Glu Arg Arg Met Lys Leu Glu Met 
945                 950                 955                 960 


Glu Ala Lys Arg Lys Gln Glu Glu Glu Glu Arg Lys Lys Arg Glu Asp 
                965                 970                 975     


Asp Glu Lys Arg Ile Gln Ala Glu Val Glu Ala Gln Leu Ala Arg Gln 
            980                 985                 990         


Lys Glu Glu Glu Ser Gln Gln Gln  Ala Val Leu Glu Gln  Glu Arg Arg 
        995                 1000                 1005             


Asp Arg  Glu Leu Ala Leu Arg  Ile Ala Gln Ser Glu  Ala Glu Leu 
    1010                 1015                 1020             


Ile Ser  Asp Glu Ala Gln Ala  Asp Leu Ala Leu Arg  Arg Asn Asp 
    1025                 1030                 1035             


Gly Thr  Arg Pro Lys Met Thr  Pro Glu Gln Met Ala  Lys Glu Met 
    1040                 1045                 1050             


Ser Glu  Phe Leu Ser Arg Gly  Pro Ala Val Leu Ala  Thr Lys Ala 
    1055                 1060                 1065             


Ala Ala  Gly Thr Lys Lys Tyr  Asp Leu Ser Lys Trp  Lys Tyr Ala 
    1070                 1075                 1080             


Glu Leu  Arg Asp Thr Ile Asn  Thr Ser Cys Asp Ile  Glu Leu Leu 
    1085                 1090                 1095             


Ala Ala  Cys Arg Glu Glu Phe  His Arg Arg Leu Lys  Val Tyr His 
    1100                 1105                 1110             


Ala Trp  Lys Ser Lys Asn Lys  Lys Arg Asn Thr Glu  Thr Glu Gln 
    1115                 1120                 1125             


Arg Ala  Pro Lys Ser Val Thr  Asp Tyr Asp Phe Ala  Pro Phe Leu 
    1130                 1135                 1140             


Asn Asn  Ser Pro Gln Gln Asn  Pro Ala Ala Gln Ile  Pro Ala Arg 
    1145                 1150                 1155             


Gln Arg  Glu Ile Glu Met Asn  Arg Gln Gln Arg Phe  Phe Arg Ile 
    1160                 1165                 1170             


Pro Phe  Ile Arg Pro Ala Asp  Gln Tyr Lys Asp Pro  Gln Ser Lys 
    1175                 1180                 1185             


Lys Lys  Gly Trp Trp Tyr Ala  His Phe Asp Gly Pro  Trp Ile Ala 
    1190                 1195                 1200             


Arg Gln  Met Glu Leu His Pro  Asp Lys Pro Pro Ile  Leu Leu Val 
    1205                 1210                 1215             


Ala Gly  Lys Asp Asp Met Glu  Met Cys Glu Leu Asn  Leu Glu Glu 
    1220                 1225                 1230             


Thr Gly  Leu Thr Arg Lys Arg  Gly Ala Glu Ile Leu  Pro Arg Gln 
    1235                 1240                 1245             


Phe Glu  Glu Ile Trp Glu Arg  Cys Gly Gly Ile Gln  Tyr Leu Gln 
    1250                 1255                 1260             


Asn Ala  Ile Glu Ser Arg Gln  Ala Arg Pro Thr Tyr  Ala Thr Ala 
    1265                 1270                 1275             


Met Leu  Gln Ser Leu Leu Lys  
    1280                 1285 


<210>  141
<211>  2028
<212>  DNA
<213>  Homo sapiens

<400>  141
atgaatgata tttcccaaaa ggctgagatt ctgctttctt catctaaacc tgtcccaaaa       60

acctatgtac caaaacttgg caagggtgat gtaaaggata agtttgaagc catgcagaga      120

gccagggaag aaagaaatca aaggagatct agagacgaaa aacaaagaag aaaagaacaa      180

tatattagag agagagaatg gaacaggaga aagcaggaga ttaaagaaat gcttgcttct      240

gatgatgagg aagatgtatc ttctaaagta gaaaaggctt atgttccaaa attaacagga      300

actgtgaagg gtagatttgc tgaaatggag aaacaaagac aagaggaaca aaggaagaga      360

acggaggagg aacgaaaacg cagaattgag caggatatgt tagaaaagag gaaaatacag      420

cgtgaattag caaaaagggc tgaacagatt gaggacataa acaatacggg aactgaatca      480

gcatcagagg aaggagatga ttcactactt ataactgtgg tacctgtcaa atcatataaa      540

acatctggaa aaatgaaaaa gaattttgag gatctagaaa aagaacgtga agagaaagaa      600

aggatcaagt acgaggaaga taaaagaata agatatgaag aacaacgacc atctctcaag      660

gaagcaaagt gtctttcatt agttatggat gatgaaatag aaagtgaagc aaaaaaagaa      720

tcactttctc ccggaaaatt gaaactaact tttgaagaac tggagcgaca aagacaagaa      780

aaccgaaaga agcaagctga agaggaagca agaaaacgtt tagaagaaga gaagcgtgct      840

tttgaagaag caaggcggca aatggtaaat gaagatgagg aaaaccaaga cacagcaaaa      900

atttttaaag ggtaccgccc tggtaaactc aaactcagtt ttgaagaaat ggaaaggcaa      960

agaagagaag atgaaaaaag gaaagcagaa gaagaagcca gaaggagaat agaggaagaa     1020

aagaaggcgt ttgctgaagc aaggagaaat atggtagtag atgatgactc cccagagatg     1080

tataagacaa tctctcaaga atttcttaca ccgggaaaac tggaaattaa ttttgaagaa     1140

ttattaaaac aaaaaatgga agaagaaaaa cgacgaacag aggaggaacg gaagcataag     1200

ctagaaatgg agaaacaaga atttgaacaa ctgagacagg aaatgggaga ggaagaggaa     1260

gaaaatgaaa cctttggatt gagcagagaa tatgaagaac tgatcaaatt aaaaaggagt     1320

ggctctattc aagctaaaaa cctaaaaagc aagtttgaaa aaattggaca gttgtctgaa     1380

aaagaaatac agaaaaaaat agaagaagag cgagcaagaa ggagagcaat tgaccttgaa     1440

attaaagagc gagaagctga aaattttcat gaggaagatg atgttgatgt taggcctgca     1500

agaaaaagcg aggctccatt tactcacaaa gtgaatatga aagctagatt tgaacaaatg     1560

gctaaggcaa gagaagaaga agaacaaaga agaattgaag aacaaaagtt actacgcatg     1620

cagtttgaac aaagggaaat tgatgcagca ctacaaaaga aaagagaaga ggaggaggag     1680

gaagaaggta gcatcatgaa tggctccact gctgaagatg aagagcaaac cagatcagga     1740

gctccatggt tcaagaagcc tcttaaaaac acatcagttg tagacagtga gccagtcaga     1800

tttacggtta aagtaacagg agaacccaaa ccagaaatta catggtggtt tgaaggagaa     1860

atactgcagg atggagaaga ctatcaatat attgaaaggg gagaaactta ctgcctttac     1920

ttaccagaaa ctttcccaga agatggagga gagtatatgt gtaaagcagt caacaataaa     1980

ggatctgcag ctagtacctg tattcttacc attgaaagta agaattaa                  2028


<210>  142
<211>  675
<212>  PRT
<213>  Homo sapiens

<400>  142

Met Asn Asp Ile Ser Gln Lys Ala Glu Ile Leu Leu Ser Ser Ser Lys 
1               5                   10                  15      


Pro Val Pro Lys Thr Tyr Val Pro Lys Leu Gly Lys Gly Asp Val Lys 
            20                  25                  30          


Asp Lys Phe Glu Ala Met Gln Arg Ala Arg Glu Glu Arg Asn Gln Arg 
        35                  40                  45              


Arg Ser Arg Asp Glu Lys Gln Arg Arg Lys Glu Gln Tyr Ile Arg Glu 
    50                  55                  60                  


Arg Glu Trp Asn Arg Arg Lys Gln Glu Ile Lys Glu Met Leu Ala Ser 
65                  70                  75                  80  


Asp Asp Glu Glu Asp Val Ser Ser Lys Val Glu Lys Ala Tyr Val Pro 
                85                  90                  95      


Lys Leu Thr Gly Thr Val Lys Gly Arg Phe Ala Glu Met Glu Lys Gln 
            100                 105                 110         


Arg Gln Glu Glu Gln Arg Lys Arg Thr Glu Glu Glu Arg Lys Arg Arg 
        115                 120                 125             


Ile Glu Gln Asp Met Leu Glu Lys Arg Lys Ile Gln Arg Glu Leu Ala 
    130                 135                 140                 


Lys Arg Ala Glu Gln Ile Glu Asp Ile Asn Asn Thr Gly Thr Glu Ser 
145                 150                 155                 160 


Ala Ser Glu Glu Gly Asp Asp Ser Leu Leu Ile Thr Val Val Pro Val 
                165                 170                 175     


Lys Ser Tyr Lys Thr Ser Gly Lys Met Lys Lys Asn Phe Glu Asp Leu 
            180                 185                 190         


Glu Lys Glu Arg Glu Glu Lys Glu Arg Ile Lys Tyr Glu Glu Asp Lys 
        195                 200                 205             


Arg Ile Arg Tyr Glu Glu Gln Arg Pro Ser Leu Lys Glu Ala Lys Cys 
    210                 215                 220                 


Leu Ser Leu Val Met Asp Asp Glu Ile Glu Ser Glu Ala Lys Lys Glu 
225                 230                 235                 240 


Ser Leu Ser Pro Gly Lys Leu Lys Leu Thr Phe Glu Glu Leu Glu Arg 
                245                 250                 255     


Gln Arg Gln Glu Asn Arg Lys Lys Gln Ala Glu Glu Glu Ala Arg Lys 
            260                 265                 270         


Arg Leu Glu Glu Glu Lys Arg Ala Phe Glu Glu Ala Arg Arg Gln Met 
        275                 280                 285             


Val Asn Glu Asp Glu Glu Asn Gln Asp Thr Ala Lys Ile Phe Lys Gly 
    290                 295                 300                 


Tyr Arg Pro Gly Lys Leu Lys Leu Ser Phe Glu Glu Met Glu Arg Gln 
305                 310                 315                 320 


Arg Arg Glu Asp Glu Lys Arg Lys Ala Glu Glu Glu Ala Arg Arg Arg 
                325                 330                 335     


Ile Glu Glu Glu Lys Lys Ala Phe Ala Glu Ala Arg Arg Asn Met Val 
            340                 345                 350         


Val Asp Asp Asp Ser Pro Glu Met Tyr Lys Thr Ile Ser Gln Glu Phe 
        355                 360                 365             


Leu Thr Pro Gly Lys Leu Glu Ile Asn Phe Glu Glu Leu Leu Lys Gln 
    370                 375                 380                 


Lys Met Glu Glu Glu Lys Arg Arg Thr Glu Glu Glu Arg Lys His Lys 
385                 390                 395                 400 


Leu Glu Met Glu Lys Gln Glu Phe Glu Gln Leu Arg Gln Glu Met Gly 
                405                 410                 415     


Glu Glu Glu Glu Glu Asn Glu Thr Phe Gly Leu Ser Arg Glu Tyr Glu 
            420                 425                 430         


Glu Leu Ile Lys Leu Lys Arg Ser Gly Ser Ile Gln Ala Lys Asn Leu 
        435                 440                 445             


Lys Ser Lys Phe Glu Lys Ile Gly Gln Leu Ser Glu Lys Glu Ile Gln 
    450                 455                 460                 


Lys Lys Ile Glu Glu Glu Arg Ala Arg Arg Arg Ala Ile Asp Leu Glu 
465                 470                 475                 480 


Ile Lys Glu Arg Glu Ala Glu Asn Phe His Glu Glu Asp Asp Val Asp 
                485                 490                 495     


Val Arg Pro Ala Arg Lys Ser Glu Ala Pro Phe Thr His Lys Val Asn 
            500                 505                 510         


Met Lys Ala Arg Phe Glu Gln Met Ala Lys Ala Arg Glu Glu Glu Glu 
        515                 520                 525             


Gln Arg Arg Ile Glu Glu Gln Lys Leu Leu Arg Met Gln Phe Glu Gln 
    530                 535                 540                 


Arg Glu Ile Asp Ala Ala Leu Gln Lys Lys Arg Glu Glu Glu Glu Glu 
545                 550                 555                 560 


Glu Glu Gly Ser Ile Met Asn Gly Ser Thr Ala Glu Asp Glu Glu Gln 
                565                 570                 575     


Thr Arg Ser Gly Ala Pro Trp Phe Lys Lys Pro Leu Lys Asn Thr Ser 
            580                 585                 590         


Val Val Asp Ser Glu Pro Val Arg Phe Thr Val Lys Val Thr Gly Glu 
        595                 600                 605             


Pro Lys Pro Glu Ile Thr Trp Trp Phe Glu Gly Glu Ile Leu Gln Asp 
    610                 615                 620                 


Gly Glu Asp Tyr Gln Tyr Ile Glu Arg Gly Glu Thr Tyr Cys Leu Tyr 
625                 630                 635                 640 


Leu Pro Glu Thr Phe Pro Glu Asp Gly Gly Glu Tyr Met Cys Lys Ala 
                645                 650                 655     


Val Asn Asn Lys Gly Ser Ala Ala Ser Thr Cys Ile Leu Thr Ile Glu 
            660                 665                 670         


Ser Lys Asn 
        675 


<210>  143
<211>  459
<212>  DNA
<213>  Homo sapiens

<400>  143
atggccaact gtgagcgtac cttcattgcg atcaaaccag atggggtcca gcggggtctt       60

gtgggagaga ttatcaagcg ttttgagcag aaaggattcc gccttgttgg tctgaaattc      120

atgcaagctt ccgaagatct tctcaaggaa cactacgttg acctgaagga ccgtccattc      180

tttgccggcc tggtgaaata catgcactca gggccggtag ttgccatggt ctgggagggg      240

ctgaatgtgg tgaagacggg ccgagtcatg ctcggggaga ccaaccctgc agactccaag      300

cctgggacca tccgtggaga cttctgcata caagttggca ggaacattat acatggcagt      360

gattctgtgg agagtgcaga gaaggagatc ggcttgtggt ttcaccctga ggaactggta      420

gattacacga gctgtgctca gaactggatc tatgaatga                             459


<210>  144
<211>  152
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Ala Asn Cys Glu Arg Thr Phe Ile Ala Ile Lys Pro Asp Gly Val 
1               5                   10                  15      


Gln Arg Gly Leu Val Gly Glu Ile Ile Lys Arg Phe Glu Gln Lys Gly 
            20                  25                  30          


Phe Arg Leu Val Gly Leu Lys Phe Met Gln Ala Ser Glu Asp Leu Leu 
        35                  40                  45              


Lys Glu His Tyr Val Asp Leu Lys Asp Arg Pro Phe Phe Ala Gly Leu 
    50                  55                  60                  


Val Lys Tyr Met His Ser Gly Pro Val Val Ala Met Val Trp Glu Gly 
65                  70                  75                  80  


Leu Asn Val Val Lys Thr Gly Arg Val Met Leu Gly Glu Thr Asn Pro 
                85                  90                  95      


Ala Asp Ser Lys Pro Gly Thr Ile Arg Gly Asp Phe Cys Ile Gln Val 
            100                 105                 110         


Gly Arg Asn Ile Ile His Gly Ser Asp Ser Val Glu Ser Ala Glu Lys 
        115                 120                 125             


Glu Ile Gly Leu Trp Phe His Pro Glu Glu Leu Val Asp Tyr Thr Ser 
    130                 135                 140                 


Cys Ala Gln Asn Trp Ile Tyr Glu 
145                 150         


<210>  145
<211>  3960
<212>  DNA
<213>  Homo sapiens

<400>  145
gcgggggcgg gctttgccga gcgcagagct gcagccgccg agccggacgt gtgcgcgaag       60

atggcgggcc ggagcatgca agcggcaaga tgtcctacag atgaattatc tttaaccaat      120

tgttcagttg tgaatgaaaa ggatttccag tctggccagc atgtgattgt gaggacctct      180

cccaatcaca ggtacacatt tacactgaag acacatccat cggtggttcc agggagcatt      240

gcattcagtt tacctcagag aaaatgggct gggctttcta ttgggcaaga aatagaagtc      300

tccttatata catttgacaa agccaaacag tgtattggca caatgaccat cgagattgat      360

ttcctgcaga aaaaaagcaa tgactccaac ccttatgaca ccgacaagat ggcagcagaa      420

tttattcagc aattcaacaa ccaggcctac tcagtgggac aacagcttgt ctttagcttc      480

aatgaaaagc tttttggctt actggtgaag gacattgaat ccatggatcc tagcatcctg      540

aagggagagc ctgcgacagg gaaaaggcag aagattgaag taggactggt tgttggaaac      600

agtcaagttg catttgaaaa agcagaaaat tcgtcactta atcttattgg caaagctaaa      660

accaaggaaa atcgccaatc aattatcaat cctgactgga actttgaaaa aatgggaata      720

ggaggtctag acaaggaatt ttcagatatt ttccgacgag catttgcctt ccgagtattt      780

cctccagaga ttgtggagca gatgggttgt atacatgtta aaggcatcct gttatatgga      840

cccccaggtt gtggtaagac tctcttggct cgacagattg gcaagatgtt gaatgcaaga      900

gagcccaaag tggtcaatgg gccagaaatc cttaacaaat atgtgggaga atcagaggct      960

aacattcgca aactttttgc tgatgctgaa gaggagcaaa ggaggcttgg tgctaacagt     1020

ggtttgcaca tcatcatctt tgatgaaatt gatgccatct gcaagcagag agggagcatg     1080

gctggtagca cgggagttca tgacactgtt gtcaaccagt tgctgtccaa aattgatggc     1140

gtggagcagc taaacaacat cctagtcatt ggaatgacca atagaccaga tctgatagat     1200

gaggctcttc ttagacctgg aagactggaa gttaaaatgg agataggctt gccagatgag     1260

aaaggccgac tacagattct tcacatccac acagcaagaa tgagagggca tcagttactc     1320

tctgctgatg tagacattaa agaactggcc gtggagacca agaatttcag tggtgctgaa     1380

ttggagggtc tggtgcgagc agcccagtcc actgctatga atagacacat aaaggccagt     1440

actaaagtgg aagtggacat ggagaaagca gaaagcctgc aagtgacgag aggagacttc     1500

cttgcttctt tggagaatga tatcaaacca gcctttggca caaaccaaga agattatgca     1560

agttacatta tgaacggtat catcaaatgg ggtgacccag ttactcgagt tctagatgat     1620

ggggagctgc tggtgcagca gactaagaac agtgaccgca caccattggt cagcgtgctt     1680

ctggaaggcc ctcctcacag tgggaagact gctttagctg caaaaattgc agaggaatcc     1740

aacttcccgt tcatcaagat ctgttctcct gataaaatga ttggcttttc tgaaacagcc     1800

aaatgtcagg ccatgaagaa gatctttgat gatgcgtaca aatcccagct cagttgtgtg     1860

gttgtggatg acattgagag attgcttgat tacgtcccta ttggccctcg attttcaaat     1920

cttgtattac aggctcttct cgttttactg aaaaaggcac ctcctcaggg ccgcaagctt     1980

cttatcattg ggaccactag ccgcaaagat gtccttcagg agatggaaat gcttaacgct     2040

ttcagcacca ccatccacgt gcccaacatt gccacaggag agcagctgtt ggaagctttg     2100

gagcttttgg gcaacttaaa ggataaggaa cgcaccacaa ttgcacagca agtcaaaggg     2160

aagaaggtct ggataggaat caagaagtta ctaatgctga tcgagatgtc cctacagatg     2220

gatcctgaat accgtgtgag aaaattcttg gccctcttaa gagaagaagg agctagcccc     2280

cttgattttg attgaaaatg aactatttga aacacacagt gaccaaggga agtgaccaag     2340

gtgaagatgg cctaggatct tcactgtctt actcaagata ctggactaag tggaacgttc     2400

tctaccttca acatgtgctc gctctgcatg attagtgcaa taaaactccc ttccttatgc     2460

atactgagat agcttagtgt ctcgtggaag gtgtcaattt ggtttagaat gctgcgctta     2520

ccttcccatg caggctaaag tgattccttc ttgctcagtc cctctgggtg ggaaccatcc     2580

agtacttgtg gacactacac gtttcaacct ctctactagc accatcaccc ttgaaaactc     2640

tcagtcagtg tcatgaatgt tgcatgacaa cagttggccg attagaaggc agactttcta     2700

catgcaaatc tggcttagta aatcgaggtg tgggccagag atcctctgac agctgtcctg     2760

agctaacact aaaagtcact gggtatttgg ttaaaggtct cccacaagac tggtattctc     2820

tttgcctgaa gaaacaaggc attgaatctc taaaatgctg ttctcaatca ttgtcagaga     2880

tgttttcaag ttgcagtcag aagatctttc ttaatagaaa gtcagatgac taccgtgttg     2940

gttgtgactt ccccttaagt ataactaatt tgctctgtgg taagagatat gctcattatt     3000

accacttaga agatgttgtt aaaaacatgt gaaagatagg tatggaaaaa gcatacaccc     3060

ccaaacagaa aggagttatt aaagtaattt acaaacctct cagcactaat tagtgtccaa     3120

ctccaagtgg gtcaattcct tagtataata ttaaggctta ctagtatcac tgctttttcc     3180

ttagcttaat gacttactta gaatttatcc tttattttaa atgatctgta ctatctagtg     3240

tctaaaacac tattctccag aaaaatcaat cattttctag ccctctccct cagtccttta     3300

ttgtccattc caatacattg aacacatttc ctttaccctc cacacacttc ttccaaaagg     3360

aagcacccgt tgagtccttt tgagggtgat ttgtcttaca actgactgac ttagcaggaa     3420

tttaattagg tcatatttgg tgatgagact tatggagtgt gcctctctct cccaactgct     3480

gcttaaaatg caaggacaag caattagaag ccatcctaag gtgcttacct cacacgccac     3540

ccatgaggct tgtggccaca gtggcacttg ggtgtggctc ctctgttatt tgtcctcatg     3600

tgagaaagca gatcatctcc aaatcttgcc atttgtatac ttttggtgga gacttggatg     3660

tcatatcttc tttgttttgg gttttcttcc ctagcttatt ttgtggcttt taaagaagtg     3720

gattgtattg tgagatcctg tgattcctgg tggccagtat cctggattcc tctaagatct     3780

tgcctctttc ctcctcatga aagcagcaca cattgtgtta acttatgtct cttgttaaat     3840

gagcttaatg tctttgtgtt ttgtccaaaa ctgtattgaa aaaatattgt ttaatgcaaa     3900

tgaaggaatg caataaagag taaatatact tgaaaaaaaa aaaaaaaaaa aaaaaaaaaa     3960


<210>  146
<211>  744
<212>  PRT
<213>  Homo sapiens

<400>  146

Met Ala Gly Arg Ser Met Gln Ala Ala Arg Cys Pro Thr Asp Glu Leu 
1               5                   10                  15      


Ser Leu Thr Asn Cys Ser Val Val Asn Glu Lys Asp Phe Gln Ser Gly 
            20                  25                  30          


Gln His Val Ile Val Arg Thr Ser Pro Asn His Arg Tyr Thr Phe Thr 
        35                  40                  45              


Leu Lys Thr His Pro Ser Val Val Pro Gly Ser Ile Ala Phe Ser Leu 
    50                  55                  60                  


Pro Gln Arg Lys Trp Ala Gly Leu Ser Ile Gly Gln Glu Ile Glu Val 
65                  70                  75                  80  


Ser Leu Tyr Thr Phe Asp Lys Ala Lys Gln Cys Ile Gly Thr Met Thr 
                85                  90                  95      


Ile Glu Ile Asp Phe Leu Gln Lys Lys Ser Asn Asp Ser Asn Pro Tyr 
            100                 105                 110         


Asp Thr Asp Lys Met Ala Ala Glu Phe Ile Gln Gln Phe Asn Asn Gln 
        115                 120                 125             


Ala Tyr Ser Val Gly Gln Gln Leu Val Phe Ser Phe Asn Glu Lys Leu 
    130                 135                 140                 


Phe Gly Leu Leu Val Lys Asp Ile Glu Ser Met Asp Pro Ser Ile Leu 
145                 150                 155                 160 


Lys Gly Glu Pro Ala Thr Gly Lys Arg Gln Lys Ile Glu Val Gly Leu 
                165                 170                 175     


Val Val Gly Asn Ser Gln Val Ala Phe Glu Lys Ala Glu Asn Ser Ser 
            180                 185                 190         


Leu Asn Leu Ile Gly Lys Ala Lys Thr Lys Glu Asn Arg Gln Ser Ile 
        195                 200                 205             


Ile Asn Pro Asp Trp Asn Phe Glu Lys Met Gly Ile Gly Gly Leu Asp 
    210                 215                 220                 


Lys Glu Phe Ser Asp Ile Phe Arg Arg Ala Phe Ala Phe Arg Val Phe 
225                 230                 235                 240 


Pro Pro Glu Ile Val Glu Gln Met Gly Cys Ile His Val Lys Gly Ile 
                245                 250                 255     


Leu Leu Tyr Gly Pro Pro Gly Cys Gly Lys Thr Leu Leu Ala Arg Gln 
            260                 265                 270         


Ile Gly Lys Met Leu Asn Ala Arg Glu Pro Lys Val Val Asn Gly Pro 
        275                 280                 285             


Glu Ile Leu Asn Lys Tyr Val Gly Glu Ser Glu Ala Asn Ile Arg Lys 
    290                 295                 300                 


Leu Phe Ala Asp Ala Glu Glu Glu Gln Arg Arg Leu Gly Ala Asn Ser 
305                 310                 315                 320 


Gly Leu His Ile Ile Ile Phe Asp Glu Ile Asp Ala Ile Cys Lys Gln 
                325                 330                 335     


Arg Gly Ser Met Ala Gly Ser Thr Gly Val His Asp Thr Val Val Asn 
            340                 345                 350         


Gln Leu Leu Ser Lys Ile Asp Gly Val Glu Gln Leu Asn Asn Ile Leu 
        355                 360                 365             


Val Ile Gly Met Thr Asn Arg Pro Asp Leu Ile Asp Glu Ala Leu Leu 
    370                 375                 380                 


Arg Pro Gly Arg Leu Glu Val Lys Met Glu Ile Gly Leu Pro Asp Glu 
385                 390                 395                 400 


Lys Gly Arg Leu Gln Ile Leu His Ile His Thr Ala Arg Met Arg Gly 
                405                 410                 415     


His Gln Leu Leu Ser Ala Asp Val Asp Ile Lys Glu Leu Ala Val Glu 
            420                 425                 430         


Thr Lys Asn Phe Ser Gly Ala Glu Leu Glu Gly Leu Val Arg Ala Ala 
        435                 440                 445             


Gln Ser Thr Ala Met Asn Arg His Ile Lys Ala Ser Thr Lys Val Glu 
    450                 455                 460                 


Val Asp Met Glu Lys Ala Glu Ser Leu Gln Val Thr Arg Gly Asp Phe 
465                 470                 475                 480 


Leu Ala Ser Leu Glu Asn Asp Ile Lys Pro Ala Phe Gly Thr Asn Gln 
                485                 490                 495     


Glu Asp Tyr Ala Ser Tyr Ile Met Asn Gly Ile Ile Lys Trp Gly Asp 
            500                 505                 510         


Pro Val Thr Arg Val Leu Asp Asp Gly Glu Leu Leu Val Gln Gln Thr 
        515                 520                 525             


Lys Asn Ser Asp Arg Thr Pro Leu Val Ser Val Leu Leu Glu Gly Pro 
    530                 535                 540                 


Pro His Ser Gly Lys Thr Ala Leu Ala Ala Lys Ile Ala Glu Glu Ser 
545                 550                 555                 560 


Asn Phe Pro Phe Ile Lys Ile Cys Ser Pro Asp Lys Met Ile Gly Phe 
                565                 570                 575     


Ser Glu Thr Ala Lys Cys Gln Ala Met Lys Lys Ile Phe Asp Asp Ala 
            580                 585                 590         


Tyr Lys Ser Gln Leu Ser Cys Val Val Val Asp Asp Ile Glu Arg Leu 
        595                 600                 605             


Leu Asp Tyr Val Pro Ile Gly Pro Arg Phe Ser Asn Leu Val Leu Gln 
    610                 615                 620                 


Ala Leu Leu Val Leu Leu Lys Lys Ala Pro Pro Gln Gly Arg Lys Leu 
625                 630                 635                 640 


Leu Ile Ile Gly Thr Thr Ser Arg Lys Asp Val Leu Gln Glu Met Glu 
                645                 650                 655     


Met Leu Asn Ala Phe Ser Thr Thr Ile His Val Pro Asn Ile Ala Thr 
            660                 665                 670         


Gly Glu Gln Leu Leu Glu Ala Leu Glu Leu Leu Gly Asn Leu Lys Asp 
        675                 680                 685             


Lys Glu Arg Thr Thr Ile Ala Gln Gln Val Lys Gly Lys Lys Val Trp 
    690                 695                 700                 


Ile Gly Ile Lys Lys Leu Leu Met Leu Ile Glu Met Ser Leu Gln Met 
705                 710                 715                 720 


Asp Pro Glu Tyr Arg Val Arg Lys Phe Leu Ala Leu Leu Arg Glu Glu 
                725                 730                 735     


Gly Ala Ser Pro Leu Asp Phe Asp 
            740                 


<210>  147
<211>  1569
<212>  DNA
<213>  Homo sapiens

<400>  147
atgagcgggt ttaattttgg aggcactggg gcccctacag gcgggttcac gtttggcact       60

gcaaagacgg caacaaccac acctgctaca gggttttctt tctccacctc tggcactgga      120

gggtttaatt ttggggctcc cttccaacca gccacaagta ccccttccac cggcctgttc      180

tcacttgcca cccagactcc ggccacacag acgacaggct tcacttttgg aacagcgact      240

cttgcttcgg ggggaactgg attttctttg gggatcggtg cttcaaagct caacttgagc      300

aacacagctg ccaccccagc catggcaaac cccagcggct ttgggctggg cagcagcaac      360

ctcactaatg ccatatcgag caccgtcacc tccagccagg gcacagcacc caccggcttt      420

gtgtttggcc cctccaccac ctctgtggct ccagctacca catctggagg cttctcattc      480

actggtggaa gcacggccca accctccggt ttcaacattg gctcagcagg gaattcagcc      540

cagcccacgg cacctgccac gttgcccttc actccggcca cgccagcagc caccacagca      600

ggtgccacac agccagctgc tcccacaccc acagccacca tcaccagcac tgggcccagc      660

ctctttgcgt caatagcaac tgctccaacc tcatctgcca ccactggact ctccctctgt      720

acccctgtga ccacagcggg cgcccccact gctgggacac agggcttcag cttaaaggca      780

cctggagcag cttccggcac ctccacaaca acatccaccg ctgccaccgc caccgccacc      840

accaccagca gcagcagcac caccggcttt gccttgaatt taaaaccact ggcgccagcc      900

gggatcccca gcaatacagc agctgccgtg accgctccac ctggccctgg cgcagctgca      960

ggggcggctg ccagctccgc catgacctac gcgcagctgg agagcctgat caacaaatgg     1020

agcctggagc tagaggacca ggagcggcac ttcctccagc aggccaccca ggtcaacgcc     1080

tgggaccgca cgctgatcga gaatggagaa aagatcacca gcctgcaccg cgaggtggag     1140

aaggtgaagc tggaccagaa gaggctggac caggagctcg acttcatcct gtcccagcag     1200

aaggagctgg aagacctgct gagcccactg gaggagttgg tcaaggagca gagcgggacc     1260

atctacctgc agcacgcgga tgaggagcgt gagaaaacct acaagctggc tgagaacatc     1320

gatgcacagc tcaagcgcat ggcccaggat ctcaaggaca tcatcgagca cctgaacacg     1380

tccggggccc ccgccgacac cagtgaccca ctgcagcaga tctgcaagat cctcaatgcg     1440

cacatggact cactgcagtg gatcgaccag aactcggccc tgctgcagag gaaggtggag     1500

gaggtgacca aggtgtgcga gggccggcgc aaggagcagg agcgcagctt ccggatcacc     1560

tttgactga                                                             1569


<210>  148
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  148

Met Ser Gly Phe Asn Phe Gly Gly Thr Gly Ala Pro Thr Gly Gly Phe 
1               5                   10                  15      


Thr Phe Gly Thr Ala Lys Thr Ala Thr Thr Thr Pro Ala Thr Gly Phe 
            20                  25                  30          


Ser Phe Ser Thr Ser Gly Thr Gly Gly Phe Asn Phe Gly Ala Pro Phe 
        35                  40                  45              


Gln Pro Ala Thr Ser Thr Pro Ser Thr Gly Leu Phe Ser Leu Ala Thr 
    50                  55                  60                  


Gln Thr Pro Ala Thr Gln Thr Thr Gly Phe Thr Phe Gly Thr Ala Thr 
65                  70                  75                  80  


Leu Ala Ser Gly Gly Thr Gly Phe Ser Leu Gly Ile Gly Ala Ser Lys 
                85                  90                  95      


Leu Asn Leu Ser Asn Thr Ala Ala Thr Pro Ala Met Ala Asn Pro Ser 
            100                 105                 110         


Gly Phe Gly Leu Gly Ser Ser Asn Leu Thr Asn Ala Ile Ser Ser Thr 
        115                 120                 125             


Val Thr Ser Ser Gln Gly Thr Ala Pro Thr Gly Phe Val Phe Gly Pro 
    130                 135                 140                 


Ser Thr Thr Ser Val Ala Pro Ala Thr Thr Ser Gly Gly Phe Ser Phe 
145                 150                 155                 160 


Thr Gly Gly Ser Thr Ala Gln Pro Ser Gly Phe Asn Ile Gly Ser Ala 
                165                 170                 175     


Gly Asn Ser Ala Gln Pro Thr Ala Pro Ala Thr Leu Pro Phe Thr Pro 
            180                 185                 190         


Ala Thr Pro Ala Ala Thr Thr Ala Gly Ala Thr Gln Pro Ala Ala Pro 
        195                 200                 205             


Thr Pro Thr Ala Thr Ile Thr Ser Thr Gly Pro Ser Leu Phe Ala Ser 
    210                 215                 220                 


Ile Ala Thr Ala Pro Thr Ser Ser Ala Thr Thr Gly Leu Ser Leu Cys 
225                 230                 235                 240 


Thr Pro Val Thr Thr Ala Gly Ala Pro Thr Ala Gly Thr Gln Gly Phe 
                245                 250                 255     


Ser Leu Lys Ala Pro Gly Ala Ala Ser Gly Thr Ser Thr Thr Thr Ser 
            260                 265                 270         


Thr Ala Ala Thr Ala Thr Ala Thr Thr Thr Ser Ser Ser Ser Thr Thr 
        275                 280                 285             


Gly Phe Ala Leu Asn Leu Lys Pro Leu Ala Pro Ala Gly Ile Pro Ser 
    290                 295                 300                 


Asn Thr Ala Ala Ala Val Thr Ala Pro Pro Gly Pro Gly Ala Ala Ala 
305                 310                 315                 320 


Gly Ala Ala Ala Ser Ser Ala Met Thr Tyr Ala Gln Leu Glu Ser Leu 
                325                 330                 335     


Ile Asn Lys Trp Ser Leu Glu Leu Glu Asp Gln Glu Arg His Phe Leu 
            340                 345                 350         


Gln Gln Ala Thr Gln Val Asn Ala Trp Asp Arg Thr Leu Ile Glu Asn 
        355                 360                 365             


Gly Glu Lys Ile Thr Ser Leu His Arg Glu Val Glu Lys Val Lys Leu 
    370                 375                 380                 


Asp Gln Lys Arg Leu Asp Gln Glu Leu Asp Phe Ile Leu Ser Gln Gln 
385                 390                 395                 400 


Lys Glu Leu Glu Asp Leu Leu Ser Pro Leu Glu Glu Leu Val Lys Glu 
                405                 410                 415     


Gln Ser Gly Thr Ile Tyr Leu Gln His Ala Asp Glu Glu Arg Glu Lys 
            420                 425                 430         


Thr Tyr Lys Leu Ala Glu Asn Ile Asp Ala Gln Leu Lys Arg Met Ala 
        435                 440                 445             


Gln Asp Leu Lys Asp Ile Ile Glu His Leu Asn Thr Ser Gly Ala Pro 
    450                 455                 460                 


Ala Asp Thr Ser Asp Pro Leu Gln Gln Ile Cys Lys Ile Leu Asn Ala 
465                 470                 475                 480 


His Met Asp Ser Leu Gln Trp Ile Asp Gln Asn Ser Ala Leu Leu Gln 
                485                 490                 495     


Arg Lys Val Glu Glu Val Thr Lys Val Cys Glu Gly Arg Arg Lys Glu 
            500                 505                 510         


Gln Glu Arg Ser Phe Arg Ile Thr Phe Asp 
        515                 520         


<210>  149
<211>  1569
<212>  DNA
<213>  Homo sapiens

<400>  149
atgtcatcca ggcctcttga aagtccacct ccttacaggc ctgatgaatt caaaccgaat       60

cattatgcac caagcaatga catatatggt ggagagatgc atgttcgacc aatgctctct      120

cagccagcct actcttttta cccagaagat gaaattcttc acttctacaa atggacctct      180

cctccaggag tgattcggat cctgtctatg ctcattattg tgatgtgcat tgccatcttt      240

gcctgtgtgg cctccacgct tgcctgggac agaggctatg gaacttccct tttaggaggt      300

agtgtaggct acccttatgg aggaagtggc tttggtagct acggaagtgg ctatggctat      360

ggctatggtt atggctatgg ctacggaggc tatacagacc caagagcagc aaagggcttc      420

atgttggcca tggctgcctt ttgtttcatt gccgcgttgg tgatctttgt taccagtgtt      480

ataagatctg aaatgtccag aacaagaaga tactacttaa gtgtgataat agtgagtgct      540

atcctgggca tcatggtgtt tattgccaca attgtctata taatgggagt gaacccaact      600

gctcagtctt ctggatctct atatggttca caaatatatg ccctctgcaa ccaattttat      660

acacctgcag ctactggact ctacgtggat cagtatttgt atcactactg tgttgtggat      720

ccccaggagg ccattgccat tgtactgggg ttcatgatta ttgtggcttt tgctttaata      780

attttctttg ctgtgaaaac tcgaagaaag atggacaggt atgacaagtc caatattttg      840

tgggacaagg aacacattta tgatgagcag ccccccaatg tcgaggagtg ggttaaaaat      900

gtgtctgcag gcacacagga cgtgccttca cccccatctg actatgtgga aagagttgac      960

agtcccatgg catactcttc caatggcaaa gtgaatgaca agcggtttta tccagagtct     1020

tcctataaat ccacgccggt tcctgaagtg gttcaggagc ttccattaac ttcgcctgtg     1080

gatgacttca ggcagcctcg ttacagcagc ggtggtaact ttgagacacc ttcaaaaaga     1140

gcacctgcaa agggaagagc aggaaggtca aagagaacag agcaagatca ctatgagaca     1200

gactacacaa ctggcggcga gtcctgtgat gagctggagg aggactggat cagggaatat     1260

ccacctatca cttcagatca acaaagacaa ctgtacaaga ggaattttga cactggccta     1320

caggaataca agagcttaca atcagaactt gatgagatca ataaagaact ctcccgtttg     1380

gataaagaat tggatgacta tagagaagaa agtgaagagt acatggctgc tgctgatgaa     1440

tacaatagac tgaagcaagt gaagggatct gcagattaca aaagtaagaa gaatcattgc     1500

aagcagttaa agagcaaatt gtcacacatc aagaagatgg ttggagacta tgatagacag     1560

aaaacatag                                                             1569


<210>  150
<211>  522
<212>  PRT
<213>  Homo sapiens

<400>  150

Met Ser Ser Arg Pro Leu Glu Ser Pro Pro Pro Tyr Arg Pro Asp Glu 
1               5                   10                  15      


Phe Lys Pro Asn His Tyr Ala Pro Ser Asn Asp Ile Tyr Gly Gly Glu 
            20                  25                  30          


Met His Val Arg Pro Met Leu Ser Gln Pro Ala Tyr Ser Phe Tyr Pro 
        35                  40                  45              


Glu Asp Glu Ile Leu His Phe Tyr Lys Trp Thr Ser Pro Pro Gly Val 
    50                  55                  60                  


Ile Arg Ile Leu Ser Met Leu Ile Ile Val Met Cys Ile Ala Ile Phe 
65                  70                  75                  80  


Ala Cys Val Ala Ser Thr Leu Ala Trp Asp Arg Gly Tyr Gly Thr Ser 
                85                  90                  95      


Leu Leu Gly Gly Ser Val Gly Tyr Pro Tyr Gly Gly Ser Gly Phe Gly 
            100                 105                 110         


Ser Tyr Gly Ser Gly Tyr Gly Tyr Gly Tyr Gly Tyr Gly Tyr Gly Tyr 
        115                 120                 125             


Gly Gly Tyr Thr Asp Pro Arg Ala Ala Lys Gly Phe Met Leu Ala Met 
    130                 135                 140                 


Ala Ala Phe Cys Phe Ile Ala Ala Leu Val Ile Phe Val Thr Ser Val 
145                 150                 155                 160 


Ile Arg Ser Glu Met Ser Arg Thr Arg Arg Tyr Tyr Leu Ser Val Ile 
                165                 170                 175     


Ile Val Ser Ala Ile Leu Gly Ile Met Val Phe Ile Ala Thr Ile Val 
            180                 185                 190         


Tyr Ile Met Gly Val Asn Pro Thr Ala Gln Ser Ser Gly Ser Leu Tyr 
        195                 200                 205             


Gly Ser Gln Ile Tyr Ala Leu Cys Asn Gln Phe Tyr Thr Pro Ala Ala 
    210                 215                 220                 


Thr Gly Leu Tyr Val Asp Gln Tyr Leu Tyr His Tyr Cys Val Val Asp 
225                 230                 235                 240 


Pro Gln Glu Ala Ile Ala Ile Val Leu Gly Phe Met Ile Ile Val Ala 
                245                 250                 255     


Phe Ala Leu Ile Ile Phe Phe Ala Val Lys Thr Arg Arg Lys Met Asp 
            260                 265                 270         


Arg Tyr Asp Lys Ser Asn Ile Leu Trp Asp Lys Glu His Ile Tyr Asp 
        275                 280                 285             


Glu Gln Pro Pro Asn Val Glu Glu Trp Val Lys Asn Val Ser Ala Gly 
    290                 295                 300                 


Thr Gln Asp Val Pro Ser Pro Pro Ser Asp Tyr Val Glu Arg Val Asp 
305                 310                 315                 320 


Ser Pro Met Ala Tyr Ser Ser Asn Gly Lys Val Asn Asp Lys Arg Phe 
                325                 330                 335     


Tyr Pro Glu Ser Ser Tyr Lys Ser Thr Pro Val Pro Glu Val Val Gln 
            340                 345                 350         


Glu Leu Pro Leu Thr Ser Pro Val Asp Asp Phe Arg Gln Pro Arg Tyr 
        355                 360                 365             


Ser Ser Gly Gly Asn Phe Glu Thr Pro Ser Lys Arg Ala Pro Ala Lys 
    370                 375                 380                 


Gly Arg Ala Gly Arg Ser Lys Arg Thr Glu Gln Asp His Tyr Glu Thr 
385                 390                 395                 400 


Asp Tyr Thr Thr Gly Gly Glu Ser Cys Asp Glu Leu Glu Glu Asp Trp 
                405                 410                 415     


Ile Arg Glu Tyr Pro Pro Ile Thr Ser Asp Gln Gln Arg Gln Leu Tyr 
            420                 425                 430         


Lys Arg Asn Phe Asp Thr Gly Leu Gln Glu Tyr Lys Ser Leu Gln Ser 
        435                 440                 445             


Glu Leu Asp Glu Ile Asn Lys Glu Leu Ser Arg Leu Asp Lys Glu Leu 
    450                 455                 460                 


Asp Asp Tyr Arg Glu Glu Ser Glu Glu Tyr Met Ala Ala Ala Asp Glu 
465                 470                 475                 480 


Tyr Asn Arg Leu Lys Gln Val Lys Gly Ser Ala Asp Tyr Lys Ser Lys 
                485                 490                 495     


Lys Asn His Cys Lys Gln Leu Lys Ser Lys Leu Ser His Ile Lys Lys 
            500                 505                 510         


Met Val Gly Asp Tyr Asp Arg Gln Lys Thr 
        515                 520         


<210>  151
<211>  1734
<212>  DNA
<213>  Homo sapiens

<400>  151
atgtcccatc aacctctcag ctgcctcact gaaaaggagg acagccccag tgaaagcaca       60

ggaaatggac ccccccacct ggcccaccca aacctggaca cgtttacccc ggaggagctg      120

ctgcagcaga tgaaagagct cctgaccgag aaccaccagc tgaaagaagc catgaagcta      180

aataatcaag ccatgaaagg gagatttgag gagctttcgg cctggacaga gaaacagaag      240

gaagaacgcc agttttttga gatacagagc aaagaagcaa aagagcgtct aatggccttg      300

agtcatgaga atgagaaatt gaaggaagag cttggaaaac taaaagggaa atcagaaagg      360

tcatctgagg accccactga tgactccagg cttcccaggg ccgaagcgga gcaggaaaag      420

gaccagctca ggacccaggt ggtgaggcta caagcagaga aggcagacct gttgggcatc      480

gtgtctgaac tgcagctcaa gctgaactcc agcggctcct cagaagattc ctttgttgaa      540

attaggatgg ctgaaggaga agcagaaggg tcagtaaaag aaatcaagca tagtcctggg      600

cccacgagaa cagtctccac tggcacggca ttgtctaaat ataggagcag atctgcagat      660

ggggccaaga attacttcga acatgaggag ttaactgtga gccagctcct gctgtgccta      720

agggaaggga atcagaaggt ggagagactt gaagttgcac tcaaggaggc caaagaaaga      780

gtttcagatt ttgaaaagaa aacaagtaat cgttctgaga ttgaaaccca gacagagggg      840

agcacagaga aagagaatga tgaagagaaa ggcccggaga ctgttggaag cgaagtggaa      900

gcactgaacc tccaggtgac atctctgttt aaggagcttc aagaggctca tacaaaactc      960

agcaaagctg agctaatgaa gaagagactt caagaaaagt gtcaggccct tgaaaggaaa     1020

aattctgcaa ttccatcaga gttgaatgaa aagcaagagc ttgtttatac taacaaaaag     1080

ttagagctac aagtggaaag catgctatca gaaatcaaaa tggaacaggc taaaacagag     1140

gatgaaaagt ccaaattaac tgtgctacag atgacacaca acaagcttct tcaagaacat     1200

aataatgcat tgaaaacaat tgaggaacta acaagaaaag agtcagaaaa agtggacagg     1260

gcagtgctga aggaactgag tgaaaaactg gaactggcag agaaggctct ggcttccaaa     1320

cagctgcaaa tggatgaaat gaagcaaacc attgccaagc aggaagagga cctggaaacc     1380

atgaccatcc tcagggctca gatggaagtt tactgttctg attttcatgc tgaaagagca     1440

gcgagagaga aaattcatga ggaaaaggag caactggcat tgcagctggc agttctgctg     1500

aaagagaatg atgctttcga agacggaggc aggcagtcct tgatggagat gcagagtcgt     1560

catggggcga gaacaagtga ctctgaccag caggcttacc ttgttcaaag aggagctgag     1620

gacagggact ggcggcaaca gcggaatatt ccgattcatt cctgccccaa gtgtggagag     1680

gttctgcctg acatagacac gttacagatt cacgtgatgg attgcatcat ttaa           1734


<210>  152
<211>  577
<212>  PRT
<213>  Homo sapiens

<400>  152

Met Ser His Gln Pro Leu Ser Cys Leu Thr Glu Lys Glu Asp Ser Pro 
1               5                   10                  15      


Ser Glu Ser Thr Gly Asn Gly Pro Pro His Leu Ala His Pro Asn Leu 
            20                  25                  30          


Asp Thr Phe Thr Pro Glu Glu Leu Leu Gln Gln Met Lys Glu Leu Leu 
        35                  40                  45              


Thr Glu Asn His Gln Leu Lys Glu Ala Met Lys Leu Asn Asn Gln Ala 
    50                  55                  60                  


Met Lys Gly Arg Phe Glu Glu Leu Ser Ala Trp Thr Glu Lys Gln Lys 
65                  70                  75                  80  


Glu Glu Arg Gln Phe Phe Glu Ile Gln Ser Lys Glu Ala Lys Glu Arg 
                85                  90                  95      


Leu Met Ala Leu Ser His Glu Asn Glu Lys Leu Lys Glu Glu Leu Gly 
            100                 105                 110         


Lys Leu Lys Gly Lys Ser Glu Arg Ser Ser Glu Asp Pro Thr Asp Asp 
        115                 120                 125             


Ser Arg Leu Pro Arg Ala Glu Ala Glu Gln Glu Lys Asp Gln Leu Arg 
    130                 135                 140                 


Thr Gln Val Val Arg Leu Gln Ala Glu Lys Ala Asp Leu Leu Gly Ile 
145                 150                 155                 160 


Val Ser Glu Leu Gln Leu Lys Leu Asn Ser Ser Gly Ser Ser Glu Asp 
                165                 170                 175     


Ser Phe Val Glu Ile Arg Met Ala Glu Gly Glu Ala Glu Gly Ser Val 
            180                 185                 190         


Lys Glu Ile Lys His Ser Pro Gly Pro Thr Arg Thr Val Ser Thr Gly 
        195                 200                 205             


Thr Ala Leu Ser Lys Tyr Arg Ser Arg Ser Ala Asp Gly Ala Lys Asn 
    210                 215                 220                 


Tyr Phe Glu His Glu Glu Leu Thr Val Ser Gln Leu Leu Leu Cys Leu 
225                 230                 235                 240 


Arg Glu Gly Asn Gln Lys Val Glu Arg Leu Glu Val Ala Leu Lys Glu 
                245                 250                 255     


Ala Lys Glu Arg Val Ser Asp Phe Glu Lys Lys Thr Ser Asn Arg Ser 
            260                 265                 270         


Glu Ile Glu Thr Gln Thr Glu Gly Ser Thr Glu Lys Glu Asn Asp Glu 
        275                 280                 285             


Glu Lys Gly Pro Glu Thr Val Gly Ser Glu Val Glu Ala Leu Asn Leu 
    290                 295                 300                 


Gln Val Thr Ser Leu Phe Lys Glu Leu Gln Glu Ala His Thr Lys Leu 
305                 310                 315                 320 


Ser Lys Ala Glu Leu Met Lys Lys Arg Leu Gln Glu Lys Cys Gln Ala 
                325                 330                 335     


Leu Glu Arg Lys Asn Ser Ala Ile Pro Ser Glu Leu Asn Glu Lys Gln 
            340                 345                 350         


Glu Leu Val Tyr Thr Asn Lys Lys Leu Glu Leu Gln Val Glu Ser Met 
        355                 360                 365             


Leu Ser Glu Ile Lys Met Glu Gln Ala Lys Thr Glu Asp Glu Lys Ser 
    370                 375                 380                 


Lys Leu Thr Val Leu Gln Met Thr His Asn Lys Leu Leu Gln Glu His 
385                 390                 395                 400 


Asn Asn Ala Leu Lys Thr Ile Glu Glu Leu Thr Arg Lys Glu Ser Glu 
                405                 410                 415     


Lys Val Asp Arg Ala Val Leu Lys Glu Leu Ser Glu Lys Leu Glu Leu 
            420                 425                 430         


Ala Glu Lys Ala Leu Ala Ser Lys Gln Leu Gln Met Asp Glu Met Lys 
        435                 440                 445             


Gln Thr Ile Ala Lys Gln Glu Glu Asp Leu Glu Thr Met Thr Ile Leu 
    450                 455                 460                 


Arg Ala Gln Met Glu Val Tyr Cys Ser Asp Phe His Ala Glu Arg Ala 
465                 470                 475                 480 


Ala Arg Glu Lys Ile His Glu Glu Lys Glu Gln Leu Ala Leu Gln Leu 
                485                 490                 495     


Ala Val Leu Leu Lys Glu Asn Asp Ala Phe Glu Asp Gly Gly Arg Gln 
            500                 505                 510         


Ser Leu Met Glu Met Gln Ser Arg His Gly Ala Arg Thr Ser Asp Ser 
        515                 520                 525             


Asp Gln Gln Ala Tyr Leu Val Gln Arg Gly Ala Glu Asp Arg Asp Trp 
    530                 535                 540                 


Arg Gln Gln Arg Asn Ile Pro Ile His Ser Cys Pro Lys Cys Gly Glu 
545                 550                 555                 560 


Val Leu Pro Asp Ile Asp Thr Leu Gln Ile His Val Met Asp Cys Ile 
                565                 570                 575     


Ile 
    


<210>  153
<211>  823
<212>  DNA
<213>  Homo sapiens

<400>  153
ctttgaaggg gaggtcacca aggagaacct gctggacttt atcaaacaca accagctgcc       60

ccttgtcatt gagttcaccg agcagagtgt gtctgactat gacggcaaac tgagcaactt      120

caaaacagca gccgagagct tcaagggcaa gatcctgttc atcttcatcg acagcgacca      180

caccgacaac cagcgcatcc tcgagttctt tggcctgaag aaggaagagt gcccggccgt      240

gcgcctcatc accctggagg aggagatgac caagtacaag cccgaatcgg aggagctgac      300

ggcagagtgg atcacagagt tctgccaccg cttcctggag ggcaaaatca agccccacct      360

gatgagccag gagctgccgg aggactggga caagcagcct gtcaaggtgc ttgttgggaa      420

gaactttgaa gacgtggctt ttgatgagaa aaaaaacgtc tttgtggagt tctatgcccc      480

atggtgtggt cactgcaaac agttggctcc catttgggat aaactgggag agacgtacaa      540

ggaccatgag aacatcgtca tcgccaagat ggactcgact gccaacgagg tggaggccgt      600

caaagtgcac agcttcccca cactcaagtt ctttcctgcc agtgccgaca ggacggtcat      660

cgattacaac ggggaacgca cgctggatgg ttttaagaaa ttcctggaga gcggtggcca      720

ggatggggca ggggatgatg acgatctcga ggacctggaa gaagcagagg agccagacat      780

ggaggaagac gatgatcaga aagctgtgaa agatgaactg taa                        823


<210>  154
<211>  273
<212>  PRT
<213>  Homo sapiens

<400>  154

Phe Glu Gly Glu Val Thr Lys Glu Asn Leu Leu Asp Phe Ile Lys His 
1               5                   10                  15      


Asn Gln Leu Pro Leu Val Ile Glu Phe Thr Glu Gln Ser Val Ser Asp 
            20                  25                  30          


Tyr Asp Gly Lys Leu Ser Asn Phe Lys Thr Ala Ala Glu Ser Phe Lys 
        35                  40                  45              


Gly Lys Ile Leu Phe Ile Phe Ile Asp Ser Asp His Thr Asp Asn Gln 
    50                  55                  60                  


Arg Ile Leu Glu Phe Phe Gly Leu Lys Lys Glu Glu Cys Pro Ala Val 
65                  70                  75                  80  


Arg Leu Ile Thr Leu Glu Glu Glu Met Thr Lys Tyr Lys Pro Glu Ser 
                85                  90                  95      


Glu Glu Leu Thr Ala Glu Trp Ile Thr Glu Phe Cys His Arg Phe Leu 
            100                 105                 110         


Glu Gly Lys Ile Lys Pro His Leu Met Ser Gln Glu Leu Pro Glu Asp 
        115                 120                 125             


Trp Asp Lys Gln Pro Val Lys Val Leu Val Gly Lys Asn Phe Glu Asp 
    130                 135                 140                 


Val Ala Phe Asp Glu Lys Lys Asn Val Phe Val Glu Phe Tyr Ala Pro 
145                 150                 155                 160 


Trp Cys Gly His Cys Lys Gln Leu Ala Pro Ile Trp Asp Lys Leu Gly 
                165                 170                 175     


Glu Thr Tyr Lys Asp His Glu Asn Ile Val Ile Ala Lys Met Asp Ser 
            180                 185                 190         


Thr Ala Asn Glu Val Glu Ala Val Lys Val His Ser Phe Pro Thr Leu 
        195                 200                 205             


Lys Phe Phe Pro Ala Ser Ala Asp Arg Thr Val Ile Asp Tyr Asn Gly 
    210                 215                 220                 


Glu Arg Thr Leu Asp Gly Phe Lys Lys Phe Leu Glu Ser Gly Gly Gln 
225                 230                 235                 240 


Asp Gly Ala Gly Asp Asp Asp Asp Leu Glu Asp Leu Glu Glu Ala Glu 
                245                 250                 255     


Glu Pro Asp Met Glu Glu Asp Asp Asp Gln Lys Ala Val Lys Asp Glu 
            260                 265                 270         


Leu 
    


<210>  155
<211>  1680
<212>  DNA
<213>  Homo sapiens

<400>  155
atgtctgacg gtctggataa tgaagagaaa cccccggctc ctccactgag gatgaatagt       60

aacaaccggg attcttcagc actcaaccac agctccaaac cacttcccat ggcccctgaa      120

gagaagaata agaaagccag gcttcgctct atcttcccag gaggagggga taaaaccaat      180

aagaagaagg agaaagagcg cccagagatc tctcttcctt cagactttga gcatacgatt      240

catgtggggt ttgatgcagt caccggggaa ttcactccag atctctatgg ctcacagatg      300

tgcccaggga agctcccaga gggaattcca gagcaatggg cacgattact ccaaacttcc      360

aacataacaa aattggaaca gaagaagaac ccacaagctg ttctagatgt tctcaaattc      420

tatgattcca aagaaacagt caacaaccag aaatacatga gctttacatc aggagataaa      480

agtgcacatg gatacatagc agcccatcct tcgagtacaa aaacagcatc tgagcctcca      540

ttggcccctc ctgtgtctga agaagaagat gaagaggaag aagaagaaga agatgaaaat      600

gagccaccac cagttatcgc accaagacca gagcatacaa aatcaatcta tactcgttct      660

gtggttgaat ccattgcttc accagcagta ccaaataaag aggtcacacc accctctgct      720

gaaaatgcca attccagtac tttgtacagg aacacagatc ggcaaagaaa aaaatccaag      780

atgacagatg aggagatctt agagaagcta agaagcattg tgagtgttgg ggacccaaag      840

aaaaaataca caagatttga aaaaattggt caaggggcat caggtactgt ttatacagca      900

ctagacattg caacaggaca agaggtggcc ataaagcaga tgaaccttca acagcaaccc      960

aagaaggaat taattattaa tgaaattctg gtcatgaggg aaaataagaa ccctaatatt     1020

gttaattatt tagatagcta cttggtgggt gatgaactat gggtagtcat ggaatacttg     1080

gctggtggct ctctgactga tgtggtcaca gagacctgta tggatgaagg acagatagca     1140

gctgtctgca gagagtgcct gcaagctttg gatttcctgc actcaaacca ggtgatccat     1200

agagatataa agagtgacaa tattcttctc gggatggatg gctctgttaa attgactgac     1260

tttgggttct gtgcccagat cactcctgag caaagtaaac gaagcactat ggtgggaacc     1320

ccatattgga tggcacctga ggtggtgact cgaaaagctt atggtccgaa agttgatatc     1380

tggtctcttg gaattatggc aattgaaatg gtggaaggtg aaccccctta ccttaatgaa     1440

aatccactca gggcattgta tctgatagcc actaatggaa ctccagagct ccagaatcct     1500

gagagactgt cagctgtatt ccgtgacttt ttaaatcgct gtcttgagat ggatgtggat     1560

aggcgaggat ctgccaagga gcttttgcag catccatttt taaaattagc caagcctctc     1620

tccagcctga ctcctctgat tatcgctgca aaggaagcaa ttaagaacag cagccgctaa     1680


<210>  156
<211>  559
<212>  PRT
<213>  Homo sapiens

<400>  156

Met Ser Asp Gly Leu Asp Asn Glu Glu Lys Pro Pro Ala Pro Pro Leu 
1               5                   10                  15      


Arg Met Asn Ser Asn Asn Arg Asp Ser Ser Ala Leu Asn His Ser Ser 
            20                  25                  30          


Lys Pro Leu Pro Met Ala Pro Glu Glu Lys Asn Lys Lys Ala Arg Leu 
        35                  40                  45              


Arg Ser Ile Phe Pro Gly Gly Gly Asp Lys Thr Asn Lys Lys Lys Glu 
    50                  55                  60                  


Lys Glu Arg Pro Glu Ile Ser Leu Pro Ser Asp Phe Glu His Thr Ile 
65                  70                  75                  80  


His Val Gly Phe Asp Ala Val Thr Gly Glu Phe Thr Pro Asp Leu Tyr 
                85                  90                  95      


Gly Ser Gln Met Cys Pro Gly Lys Leu Pro Glu Gly Ile Pro Glu Gln 
            100                 105                 110         


Trp Ala Arg Leu Leu Gln Thr Ser Asn Ile Thr Lys Leu Glu Gln Lys 
        115                 120                 125             


Lys Asn Pro Gln Ala Val Leu Asp Val Leu Lys Phe Tyr Asp Ser Lys 
    130                 135                 140                 


Glu Thr Val Asn Asn Gln Lys Tyr Met Ser Phe Thr Ser Gly Asp Lys 
145                 150                 155                 160 


Ser Ala His Gly Tyr Ile Ala Ala His Pro Ser Ser Thr Lys Thr Ala 
                165                 170                 175     


Ser Glu Pro Pro Leu Ala Pro Pro Val Ser Glu Glu Glu Asp Glu Glu 
            180                 185                 190         


Glu Glu Glu Glu Glu Asp Glu Asn Glu Pro Pro Pro Val Ile Ala Pro 
        195                 200                 205             


Arg Pro Glu His Thr Lys Ser Ile Tyr Thr Arg Ser Val Val Glu Ser 
    210                 215                 220                 


Ile Ala Ser Pro Ala Val Pro Asn Lys Glu Val Thr Pro Pro Ser Ala 
225                 230                 235                 240 


Glu Asn Ala Asn Ser Ser Thr Leu Tyr Arg Asn Thr Asp Arg Gln Arg 
                245                 250                 255     


Lys Lys Ser Lys Met Thr Asp Glu Glu Ile Leu Glu Lys Leu Arg Ser 
            260                 265                 270         


Ile Val Ser Val Gly Asp Pro Lys Lys Lys Tyr Thr Arg Phe Glu Lys 
        275                 280                 285             


Ile Gly Gln Gly Ala Ser Gly Thr Val Tyr Thr Ala Leu Asp Ile Ala 
    290                 295                 300                 


Thr Gly Gln Glu Val Ala Ile Lys Gln Met Asn Leu Gln Gln Gln Pro 
305                 310                 315                 320 


Lys Lys Glu Leu Ile Ile Asn Glu Ile Leu Val Met Arg Glu Asn Lys 
                325                 330                 335     


Asn Pro Asn Ile Val Asn Tyr Leu Asp Ser Tyr Leu Val Gly Asp Glu 
            340                 345                 350         


Leu Trp Val Val Met Glu Tyr Leu Ala Gly Gly Ser Leu Thr Asp Val 
        355                 360                 365             


Val Thr Glu Thr Cys Met Asp Glu Gly Gln Ile Ala Ala Val Cys Arg 
    370                 375                 380                 


Glu Cys Leu Gln Ala Leu Asp Phe Leu His Ser Asn Gln Val Ile His 
385                 390                 395                 400 


Arg Asp Ile Lys Ser Asp Asn Ile Leu Leu Gly Met Asp Gly Ser Val 
                405                 410                 415     


Lys Leu Thr Asp Phe Gly Phe Cys Ala Gln Ile Thr Pro Glu Gln Ser 
            420                 425                 430         


Lys Arg Ser Thr Met Val Gly Thr Pro Tyr Trp Met Ala Pro Glu Val 
        435                 440                 445             


Val Thr Arg Lys Ala Tyr Gly Pro Lys Val Asp Ile Trp Ser Leu Gly 
    450                 455                 460                 


Ile Met Ala Ile Glu Met Val Glu Gly Glu Pro Pro Tyr Leu Asn Glu 
465                 470                 475                 480 


Asn Pro Leu Arg Ala Leu Tyr Leu Ile Ala Thr Asn Gly Thr Pro Glu 
                485                 490                 495     


Leu Gln Asn Pro Glu Arg Leu Ser Ala Val Phe Arg Asp Phe Leu Asn 
            500                 505                 510         


Arg Cys Leu Glu Met Asp Val Asp Arg Arg Gly Ser Ala Lys Glu Leu 
        515                 520                 525             


Leu Gln His Pro Phe Leu Lys Leu Ala Lys Pro Leu Ser Ser Leu Thr 
    530                 535                 540                 


Pro Leu Ile Ile Ala Ala Lys Glu Ala Ile Lys Asn Ser Ser Arg 
545                 550                 555                 


<210>  157
<211>  1518
<212>  DNA
<213>  Homo sapiens

<400>  157
atggggcgcg tcgtcgcgga gctcgtctcc tcgctgctgg ggttgtggct gttgctgtgc       60

agctgcggat gccccgaggg cgccgagctg cgtgctccgc cagataaaat cgcgattatt      120

ggagccggaa ttggtggcac ttcagcagcc tattacctgc ggcagaaatt tgggaaagat      180

gtgaagatag acctgtttga aagagaagag gtcgggggcc gcctggctac catgatggtg      240

caggggcaag aatacgaggc aggaggttct gtcatccatc ctttaaatct gcacatgaaa      300

cgttttgtca aagacctggg tctctctgct gttcaggcct ctggtggcct actggggata      360

tataatggag agactctggt atttgaggag agcaactggt tcataattaa cgtgattaaa      420

ttagtttggc gctatggatt tcaatccctc cgtatgcaca tgtgggtaga ggacgtgtta      480

gacaagttca tgaggatcta ccgctaccag tctcatgact atgccttcag tagtgtcgaa      540

aaattacttc atgctctagg aggagatgac ttccttggaa tgcttaatcg aacacttctt      600

gaaaccttgc aaaaggccgg cttttctgag aagttcctca atgaaatgat tgctcctgtt      660

atgagggtca attatggcca aagcacggac atcaatgcct ttgtgggggc ggtgtcactg      720

tcctgttctg attctggcct ttgggcagta gaaggtggca ataaacttgt ttgctcaggg      780

cttctgcagg catccaaaag caatcttata tctggctcag taatgtacat cgaggagaaa      840

acaaagacca agtacacagg aaatccaaca aagatgtatg aagtggtcta ccaaattgga      900

actgagactc gttcagactt ctatgacatc gtcttggtgg ccactccgtt gaatcgaaaa      960

atgtcgaata ttacttttct caactttgat cctccaattg aggaattcca tcaatattat     1020

caacatatag tgacaacttt agttaagggg gaattgaata catctatctt tagctctaga     1080

cccatagata aatttggcct taatacagtt ttaaccactg ataattcaga tttgttcatt     1140

aacagtattg ggattgtgcc ctctgtgaga gaaaaggaag atcctgagcc atcaacagat     1200

ggaacatatg tttggaagat cttttcccaa gaaactctta ctaaagcaca aattttaaag     1260

ctctttctgt cctatgatta tgctgtgaag aagccatggc ttgcatatcc tcactataag     1320

cccccggaga aatgcccctc tatcattctc catgatcgac tttattacct caatggcata     1380

gagtgtgcag caagtgccat ggagatgagt gccattgcag cccacaacgc tgcactcctt     1440

gcctatcacc gctggaacgg gcacacagac atgattgatc aggatggctt atatgagaaa     1500

cttaaaactg aactatga                                                   1518


<210>  158
<211>  505
<212>  PRT
<213>  Homo sapiens

<400>  158

Met Gly Arg Val Val Ala Glu Leu Val Ser Ser Leu Leu Gly Leu Trp 
1               5                   10                  15      


Leu Leu Leu Cys Ser Cys Gly Cys Pro Glu Gly Ala Glu Leu Arg Ala 
            20                  25                  30          


Pro Pro Asp Lys Ile Ala Ile Ile Gly Ala Gly Ile Gly Gly Thr Ser 
        35                  40                  45              


Ala Ala Tyr Tyr Leu Arg Gln Lys Phe Gly Lys Asp Val Lys Ile Asp 
    50                  55                  60                  


Leu Phe Glu Arg Glu Glu Val Gly Gly Arg Leu Ala Thr Met Met Val 
65                  70                  75                  80  


Gln Gly Gln Glu Tyr Glu Ala Gly Gly Ser Val Ile His Pro Leu Asn 
                85                  90                  95      


Leu His Met Lys Arg Phe Val Lys Asp Leu Gly Leu Ser Ala Val Gln 
            100                 105                 110         


Ala Ser Gly Gly Leu Leu Gly Ile Tyr Asn Gly Glu Thr Leu Val Phe 
        115                 120                 125             


Glu Glu Ser Asn Trp Phe Ile Ile Asn Val Ile Lys Leu Val Trp Arg 
    130                 135                 140                 


Tyr Gly Phe Gln Ser Leu Arg Met His Met Trp Val Glu Asp Val Leu 
145                 150                 155                 160 


Asp Lys Phe Met Arg Ile Tyr Arg Tyr Gln Ser His Asp Tyr Ala Phe 
                165                 170                 175     


Ser Ser Val Glu Lys Leu Leu His Ala Leu Gly Gly Asp Asp Phe Leu 
            180                 185                 190         


Gly Met Leu Asn Arg Thr Leu Leu Glu Thr Leu Gln Lys Ala Gly Phe 
        195                 200                 205             


Ser Glu Lys Phe Leu Asn Glu Met Ile Ala Pro Val Met Arg Val Asn 
    210                 215                 220                 


Tyr Gly Gln Ser Thr Asp Ile Asn Ala Phe Val Gly Ala Val Ser Leu 
225                 230                 235                 240 


Ser Cys Ser Asp Ser Gly Leu Trp Ala Val Glu Gly Gly Asn Lys Leu 
                245                 250                 255     


Val Cys Ser Gly Leu Leu Gln Ala Ser Lys Ser Asn Leu Ile Ser Gly 
            260                 265                 270         


Ser Val Met Tyr Ile Glu Glu Lys Thr Lys Thr Lys Tyr Thr Gly Asn 
        275                 280                 285             


Pro Thr Lys Met Tyr Glu Val Val Tyr Gln Ile Gly Thr Glu Thr Arg 
    290                 295                 300                 


Ser Asp Phe Tyr Asp Ile Val Leu Val Ala Thr Pro Leu Asn Arg Lys 
305                 310                 315                 320 


Met Ser Asn Ile Thr Phe Leu Asn Phe Asp Pro Pro Ile Glu Glu Phe 
                325                 330                 335     


His Gln Tyr Tyr Gln His Ile Val Thr Thr Leu Val Lys Gly Glu Leu 
            340                 345                 350         


Asn Thr Ser Ile Phe Ser Ser Arg Pro Ile Asp Lys Phe Gly Leu Asn 
        355                 360                 365             


Thr Val Leu Thr Thr Asp Asn Ser Asp Leu Phe Ile Asn Ser Ile Gly 
    370                 375                 380                 


Ile Val Pro Ser Val Arg Glu Lys Glu Asp Pro Glu Pro Ser Thr Asp 
385                 390                 395                 400 


Gly Thr Tyr Val Trp Lys Ile Phe Ser Gln Glu Thr Leu Thr Lys Ala 
                405                 410                 415     


Gln Ile Leu Lys Leu Phe Leu Ser Tyr Asp Tyr Ala Val Lys Lys Pro 
            420                 425                 430         


Trp Leu Ala Tyr Pro His Tyr Lys Pro Pro Glu Lys Cys Pro Ser Ile 
        435                 440                 445             


Ile Leu His Asp Arg Leu Tyr Tyr Leu Asn Gly Ile Glu Cys Ala Ala 
    450                 455                 460                 


Ser Ala Met Glu Met Ser Ala Ile Ala Ala His Asn Ala Ala Leu Leu 
465                 470                 475                 480 


Ala Tyr His Arg Trp Asn Gly His Thr Asp Met Ile Asp Gln Asp Gly 
                485                 490                 495     


Leu Tyr Glu Lys Leu Lys Thr Glu Leu 
            500                 505 


<210>  159
<211>  2175
<212>  DNA
<213>  Homo sapiens

<400>  159
atgagtgctg aggggtacca gtacagagcg ctgtatgatt ataaaaagga aagagaagaa       60

gatattgact tgcacttggg tgacatattg actgtgaata aagggtcctt agtagctctt      120

ggattcagtg atggacagga agccaggcct gaagaaattg gctggttaaa tggctataat      180

gaaaccacag gggaaagggg ggactttccg ggaacttacg tagaatatat tggaaggaaa      240

aaaatctcgc ctcccacacc aaagccccgg ccacctcggc ctcttcctgt tgcaccaggt      300

tcttcgaaaa ctgaagcaga tgttgaacaa caagctttga ctctcccgga tcttgcagag      360

cagtttgccc ctcctgacat tgccccgcct cttcttatca agctcgtgga agccattgaa      420

aagaaaggtc tggaatgttc aactctatac agaacacaga gctccagcaa cctggcagaa      480

ttacgacagc ttcttgattg tgatacaccc tccgtggact tggaaatgat cgatgtgcac      540

gttttggctg acgctttcaa acgctatctc ctggacttac caaatcctgt cattccagca      600

gccgtttaca gtgaaatgat ttctttagct ccagaagtac aaagctccga agaatatatt      660

cagctattga agaagcttat taggtcgcct agcatacctc atcagtattg gcttacgctt      720

cagtatttgt taaaacattt cttcaagctc tctcaaacct ccagcaaaaa tctgttgaat      780

gcaagagtac tctctgaaat tttcagccct atgcttttca gattctcagc agccagctct      840

gataatactg aaaacctcat aaaagttata gaaattttaa tctcaactga atggaatgaa      900

cgacagcctg caccagcact gcctcctaaa ccaccaaaac ctactactgt agccaacaac      960

ggtatgaata acaatatgtc cttacaagat gctgaatggt actggggaga tatctcgagg     1020

gaagaagtga atgaaaaact tcgagataca gcagacggga cctttttggt acgagatgcg     1080

tctactaaaa tgcatggtga ttatactctt acactaagga aagggggaaa taacaaatta     1140

atcaaaatat ttcatcgaga tgggaaatat ggcttctctg acccattaac cttcagttct     1200

gtggttgaat taataaacca ctaccggaat gaatctctag ctcagtataa tcccaaattg     1260

gatgtgaaat tactttatcc agtatccaaa taccaacagg atcaagttgt caaagaagat     1320

aatattgaag ctgtagggaa aaaattacat gaatataaca ctcagtttca agaaaaaagt     1380

cgagaatatg atagattata tgaagaatat acccgcacat cccaggaaat ccaaatgaaa     1440

aggacagcta ttgaagcatt taatgaaacc ataaaaatat ttgaagaaca gtgccagacc     1500

caagagcggt acagcaaaga atacatagaa aagtttaaac gtgaaggcaa tgagaaagaa     1560

atacaaagga ttatgcataa ttatgataag ttgaagtctc gaatcagtga aattattgac     1620

agtagaagaa gattggaaga agacttgaag aagcaggcag ctgagtatcg agaaattgac     1680

aaacgtatga acagcattaa accagacctt atccagctga gaaagacgag agaccaatac     1740

ttgatgtggt tgactcaaaa aggtgttcgg caaaagaagt tgaacgagtg gttgggcaat     1800

gaaaacactg aagaccaata ttcactggtg gaagatgatg aagatttgcc ccatcatgat     1860

gagaagacat ggaatgttgg aagcagcaac cgaaacaaag ctgaaaacct gttgcgaggg     1920

aagcgagatg gcacttttct tgtccgggag agcagtaaac agggctgcta tgcctgctct     1980

gtagtggtgg acggcgaagt aaagcattgt gtcataaaca aaacagcaac tggctatggc     2040

tttgccgagc cctataactt gtacagctct ctgaaagaac tggtgctaca ttaccaacac     2100

acctcccttg tgcagcacaa cgactccctc aatgtcacac tagcctaccc agtatatgca     2160

cagcagaggc gatga                                                      2175


<210>  160
<211>  724
<212>  PRT
<213>  Homo sapiens

<400>  160

Met Ser Ala Glu Gly Tyr Gln Tyr Arg Ala Leu Tyr Asp Tyr Lys Lys 
1               5                   10                  15      


Glu Arg Glu Glu Asp Ile Asp Leu His Leu Gly Asp Ile Leu Thr Val 
            20                  25                  30          


Asn Lys Gly Ser Leu Val Ala Leu Gly Phe Ser Asp Gly Gln Glu Ala 
        35                  40                  45              


Arg Pro Glu Glu Ile Gly Trp Leu Asn Gly Tyr Asn Glu Thr Thr Gly 
    50                  55                  60                  


Glu Arg Gly Asp Phe Pro Gly Thr Tyr Val Glu Tyr Ile Gly Arg Lys 
65                  70                  75                  80  


Lys Ile Ser Pro Pro Thr Pro Lys Pro Arg Pro Pro Arg Pro Leu Pro 
                85                  90                  95      


Val Ala Pro Gly Ser Ser Lys Thr Glu Ala Asp Val Glu Gln Gln Ala 
            100                 105                 110         


Leu Thr Leu Pro Asp Leu Ala Glu Gln Phe Ala Pro Pro Asp Ile Ala 
        115                 120                 125             


Pro Pro Leu Leu Ile Lys Leu Val Glu Ala Ile Glu Lys Lys Gly Leu 
    130                 135                 140                 


Glu Cys Ser Thr Leu Tyr Arg Thr Gln Ser Ser Ser Asn Leu Ala Glu 
145                 150                 155                 160 


Leu Arg Gln Leu Leu Asp Cys Asp Thr Pro Ser Val Asp Leu Glu Met 
                165                 170                 175     


Ile Asp Val His Val Leu Ala Asp Ala Phe Lys Arg Tyr Leu Leu Asp 
            180                 185                 190         


Leu Pro Asn Pro Val Ile Pro Ala Ala Val Tyr Ser Glu Met Ile Ser 
        195                 200                 205             


Leu Ala Pro Glu Val Gln Ser Ser Glu Glu Tyr Ile Gln Leu Leu Lys 
    210                 215                 220                 


Lys Leu Ile Arg Ser Pro Ser Ile Pro His Gln Tyr Trp Leu Thr Leu 
225                 230                 235                 240 


Gln Tyr Leu Leu Lys His Phe Phe Lys Leu Ser Gln Thr Ser Ser Lys 
                245                 250                 255     


Asn Leu Leu Asn Ala Arg Val Leu Ser Glu Ile Phe Ser Pro Met Leu 
            260                 265                 270         


Phe Arg Phe Ser Ala Ala Ser Ser Asp Asn Thr Glu Asn Leu Ile Lys 
        275                 280                 285             


Val Ile Glu Ile Leu Ile Ser Thr Glu Trp Asn Glu Arg Gln Pro Ala 
    290                 295                 300                 


Pro Ala Leu Pro Pro Lys Pro Pro Lys Pro Thr Thr Val Ala Asn Asn 
305                 310                 315                 320 


Gly Met Asn Asn Asn Met Ser Leu Gln Asp Ala Glu Trp Tyr Trp Gly 
                325                 330                 335     


Asp Ile Ser Arg Glu Glu Val Asn Glu Lys Leu Arg Asp Thr Ala Asp 
            340                 345                 350         


Gly Thr Phe Leu Val Arg Asp Ala Ser Thr Lys Met His Gly Asp Tyr 
        355                 360                 365             


Thr Leu Thr Leu Arg Lys Gly Gly Asn Asn Lys Leu Ile Lys Ile Phe 
    370                 375                 380                 


His Arg Asp Gly Lys Tyr Gly Phe Ser Asp Pro Leu Thr Phe Ser Ser 
385                 390                 395                 400 


Val Val Glu Leu Ile Asn His Tyr Arg Asn Glu Ser Leu Ala Gln Tyr 
                405                 410                 415     


Asn Pro Lys Leu Asp Val Lys Leu Leu Tyr Pro Val Ser Lys Tyr Gln 
            420                 425                 430         


Gln Asp Gln Val Val Lys Glu Asp Asn Ile Glu Ala Val Gly Lys Lys 
        435                 440                 445             


Leu His Glu Tyr Asn Thr Gln Phe Gln Glu Lys Ser Arg Glu Tyr Asp 
    450                 455                 460                 


Arg Leu Tyr Glu Glu Tyr Thr Arg Thr Ser Gln Glu Ile Gln Met Lys 
465                 470                 475                 480 


Arg Thr Ala Ile Glu Ala Phe Asn Glu Thr Ile Lys Ile Phe Glu Glu 
                485                 490                 495     


Gln Cys Gln Thr Gln Glu Arg Tyr Ser Lys Glu Tyr Ile Glu Lys Phe 
            500                 505                 510         


Lys Arg Glu Gly Asn Glu Lys Glu Ile Gln Arg Ile Met His Asn Tyr 
        515                 520                 525             


Asp Lys Leu Lys Ser Arg Ile Ser Glu Ile Ile Asp Ser Arg Arg Arg 
    530                 535                 540                 


Leu Glu Glu Asp Leu Lys Lys Gln Ala Ala Glu Tyr Arg Glu Ile Asp 
545                 550                 555                 560 


Lys Arg Met Asn Ser Ile Lys Pro Asp Leu Ile Gln Leu Arg Lys Thr 
                565                 570                 575     


Arg Asp Gln Tyr Leu Met Trp Leu Thr Gln Lys Gly Val Arg Gln Lys 
            580                 585                 590         


Lys Leu Asn Glu Trp Leu Gly Asn Glu Asn Thr Glu Asp Gln Tyr Ser 
        595                 600                 605             


Leu Val Glu Asp Asp Glu Asp Leu Pro His His Asp Glu Lys Thr Trp 
    610                 615                 620                 


Asn Val Gly Ser Ser Asn Arg Asn Lys Ala Glu Asn Leu Leu Arg Gly 
625                 630                 635                 640 


Lys Arg Asp Gly Thr Phe Leu Val Arg Glu Ser Ser Lys Gln Gly Cys 
                645                 650                 655     


Tyr Ala Cys Ser Val Val Val Asp Gly Glu Val Lys His Cys Val Ile 
            660                 665                 670         


Asn Lys Thr Ala Thr Gly Tyr Gly Phe Ala Glu Pro Tyr Asn Leu Tyr 
        675                 680                 685             


Ser Ser Leu Lys Glu Leu Val Leu His Tyr Gln His Thr Ser Leu Val 
    690                 695                 700                 


Gln His Asn Asp Ser Leu Asn Val Thr Leu Ala Tyr Pro Val Tyr Ala 
705                 710                 715                 720 


Gln Gln Arg Arg 
                


<210>  161
<211>  993
<212>  DNA
<213>  Homo sapiens

<400>  161
atgtccgaca gcgagaagct caacctggac tcgatcatcg ggcgcctgct ggaagtgcag       60

ggctcgcggc ctggcaagaa tgtacagctg acagagaacg agatccgcgg tctgtgcctg      120

aaatcccggg agatttttct gagccagccc attcttctgg agctggaggc acccctcaag      180

atctgcggtg acatacacgg ccagtactac gaccttctgc gactatttga gtatggcggt      240

ttccctcccg agagcaacta cctctttctg ggggactatg tggacagggg caagcagtcc      300

ttggagacca tctgcctgct gctggcctat aagatcaagt accccgagaa cttcttcctg      360

ctccgtggga accacgagtg tgccagcatc aaccgcatct atggtttcta cgatgagtgc      420

aagagacgct acaacatcaa actgtggaaa accttcactg actgcttcaa ctgcctgccc      480

atcgcggcca tagtggacga aaagatcttc tgctgccacg gaggcctgtc cccggacctg      540

cagtctatgg agcagattcg gcggatcatg cggcccacag atgtgcctga ccagggcctg      600

ctgtgtgacc tgctgtggtc tgaccctgac aaggacgtgc agggctgggg cgagaacgac      660

cgtggcgtct cttttacctt tggagccgag gtggtggcca agttcctcca caagcacgac      720

ttggacctca tctgccgagc acaccaggtg gtagaagacg gctacgagtt ctttgccaag      780

cggcagctgg tgacactttt ctcagctccc aactactgtg gcgagtttga caatgctggc      840

gccatgatga gtgtggacga gaccctcatg tgctctttcc agatcctcaa gcccgccgac      900

aagaacaagg ggaagtacgg gcagttcagt ggcctgaacc ctggaggccg acccatcacc      960

ccaccccgca attccgccaa agccaagaaa tag                                   993


<210>  162
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  162

Met Ser Asp Ser Glu Lys Leu Asn Leu Asp Ser Ile Ile Gly Arg Leu 
1               5                   10                  15      


Leu Glu Val Gln Gly Ser Arg Pro Gly Lys Asn Val Gln Leu Thr Glu 
            20                  25                  30          


Asn Glu Ile Arg Gly Leu Cys Leu Lys Ser Arg Glu Ile Phe Leu Ser 
        35                  40                  45              


Gln Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp 
    50                  55                  60                  


Ile His Gly Gln Tyr Tyr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly 
65                  70                  75                  80  


Phe Pro Pro Glu Ser Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg 
                85                  90                  95      


Gly Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile 
            100                 105                 110         


Lys Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala 
        115                 120                 125             


Ser Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Tyr 
    130                 135                 140                 


Asn Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro 
145                 150                 155                 160 


Ile Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu 
                165                 170                 175     


Ser Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro 
            180                 185                 190         


Thr Asp Val Pro Asp Gln Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp 
        195                 200                 205             


Pro Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser 
    210                 215                 220                 


Phe Thr Phe Gly Ala Glu Val Val Ala Lys Phe Leu His Lys His Asp 
225                 230                 235                 240 


Leu Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu 
                245                 250                 255     


Phe Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr 
            260                 265                 270         


Cys Gly Glu Phe Asp Asn Ala Gly Ala Met Met Ser Val Asp Glu Thr 
        275                 280                 285             


Leu Met Cys Ser Phe Gln Ile Leu Lys Pro Ala Asp Lys Asn Lys Gly 
    290                 295                 300                 


Lys Tyr Gly Gln Phe Ser Gly Leu Asn Pro Gly Gly Arg Pro Ile Thr 
305                 310                 315                 320 


Pro Pro Arg Asn Ser Ala Lys Ala Lys Lys 
                325                 330 


<210>  163
<211>  3093
<212>  DNA
<213>  Homo sapiens

<400>  163
atgaagatgg cggacgcgaa gcagaagcgg aacgagcagc tgaaacgctg gatcggctcc       60

gagacggacc tcgagcctcc ggtggtgaag cgccagaaga ccaaggtgaa gttcgacgat      120

ggcgccgtct tcctggctgc ttgctccagc ggcgacacgg acgaggtcct caagctgctg      180

caccgcggcg ccgacatcaa ttacgccaat gtggacggac tcactgccct gcaccaggct      240

tgcattgatg acaatgttga tatggtgaag tttctggtag aaaatggagc aaatattaat      300

caacctgata atgaaggctg gataccacta catgcagcag cttcctgtgg atatcttgat      360

attgcagagt ttttgattgg tcaaggagca catgtagggg ctgtcaacag tgaaggagat      420

acacctttag atattgcgga ggaggaggca atggaagagc tacttcaaaa tgaagttaat      480

cggcaagggg ttgatataga agcagctcga aaggaagaag aacggatcat gcttagagat      540

gccaggcagt ggctaaatag tggtcatata aatgatgtcc ggcatgcaaa atctggaggt      600

acagcacttc acgttgcagc tgctaaaggc tatacggaag ttttaaaact tttaatacag      660

gcaggctatg atgttaatat taaagactat gatggctgga cacctcttca tgctgcagct      720

cattggggta aagaagaagc atgtcgaatt ttagtggaca atctgtgtga tatggagatg      780

gtcaacaaag tgggccaaac agcctttgat gtagcagatg aagacatttt aggatattta      840

gaagagttgc aaaagaaaca aaatctgctc catagtgaaa aacgggacaa gaaatctcca      900

ctaattgaat caacagcaaa tatggacaat aatcagtcac agaagacctt taaaaacaaa      960

gagacgttga ttattgaacc agagaaaaat gcatcccgta ttgaatctct ggaacaagaa     1020

aaggttgatg aagaagaaga aggaaagaag gatgagtcta gctgctctag tgaagaagat     1080

gaggaagatg actcggaatc agaagctgaa acagataaga caaaacccct ggcttctgta     1140

actaatgcca acacttctag tacacaagca gctcctgtag ctgttacaac acctactgtg     1200

tcatcaggtc aagcaacacc tacatcacct attaaaaagt ttccaaccac agctacaaaa     1260

atttctccca aagaagaaga gagaaaagat gagtctcctg caacttggag gttaggactt     1320

agaaagacgg gcagctatgg tgcacttgct gaaatcacag catctaaaga gggtcagaaa     1380

gaaaaagata ctgcaggtgt tacacgttca gcttcaagtc ccagactttc ctcctctttg     1440

gataataaag aaaaggagaa agatagtaaa ggaactaggc ttgcatatgt tgcacctaca     1500

ataccaagac gactagccag tacatctgac attgaagaga aagaaaacag agattcttca     1560

agtttgcgaa caagtagttc atatacaagg agaaaatggg aagatgatct taaaaaaaat     1620

agctcagtta atgaaggatc aacgtatcat aaaagttgct cctttggtag aagacaagat     1680

gatttgatta gttctagtgt tccaagcacc acatcaacac caacagttac ctctgcagct     1740

gggcttcaga aaagcctgct ttccagcaca agcactacta caaagattac aacgggttct     1800

tcctcagcag gcacacaaag cagtacctca aatcgtttgt gggctgagga tagtactgag     1860

aaagaaaagg acagtgttcc tacggcagtg accattcctg ttgctccaac tgttgtaaat     1920

gctgcagctt ctaccacaac cctgactaca actactgctg gcactgtctc ctccacaaca     1980

gaggtcaggg agagacgcag atcatacctc actcctgtta gggatgaaga gtctgaatcc     2040

caaagaaaag caagatctag acaagcaaga caatctagaa gatcaacaca gggagtgaca     2100

ttaactgatc ttcaagaagc tgagaaaaca ataggaagaa gtcgttctac ccgaaccaga     2160

gaacaagaaa atgaagaaaa agaaaaagag gaaaaagaga aacaagataa agagaaacaa     2220

gaagaaaaga aggagtcaga aacatctaga gaagatgaat ataaacaaaa gtactccaga     2280

acgtatgatg agacttacca gcgttatagg ccagtatcaa cttcaagttc aaccactcca     2340

tcctcttcac tttctactat gagcagttca ctgtatgctt caagtcaact aaacaggcca     2400

aatagtcttg taggcataac ttctgcttac tccagaggaa taacaaaaga aaatgaaaga     2460

gagggagaaa aaagagaaga ggagaaagaa ggagaagata aatcacaacc taaatcaatc     2520

agagaacgac gacgaccaag agagaaaaga agatctacag gagtttcatt ttggacacaa     2580

gatagtgatg aaaatgaaca agaacaacaa tcagacacag aagagggatc caataagaaa     2640

gaaactcaga cggattccat ttctagatat gaaaccagtt ctacatcagc tggtgatcga     2700

tatgattcct tgctgggtcg ctctggatca tacagttact tagaagaaag aaaaccttac     2760

agcagcaggc tagaaaagga tgactcaact gactttaaaa agctttatga acaaattcta     2820

gctgaaaatg aaaagctgaa ggcacagcta catgatacaa atatggaact aacagatctt     2880

aaattacagt tggaaaaggc cacccagaga caagaaagat ttgctgatag atcactgttg     2940

gaaatggaaa aaagggaacg aagagctcta gaaagaagaa tatctgaaat ggaagaagag     3000

ctcaaaatgt taccagacct aaaagcagac aaccagaggc taaaggatga aaatggggcc     3060

ttgatcagag ttataagcaa actttccaaa taa                                  3093


<210>  164
<211>  1030
<212>  PRT
<213>  Homo sapiens

<400>  164

Met Lys Met Ala Asp Ala Lys Gln Lys Arg Asn Glu Gln Leu Lys Arg 
1               5                   10                  15      


Trp Ile Gly Ser Glu Thr Asp Leu Glu Pro Pro Val Val Lys Arg Gln 
            20                  25                  30          


Lys Thr Lys Val Lys Phe Asp Asp Gly Ala Val Phe Leu Ala Ala Cys 
        35                  40                  45              


Ser Ser Gly Asp Thr Asp Glu Val Leu Lys Leu Leu His Arg Gly Ala 
    50                  55                  60                  


Asp Ile Asn Tyr Ala Asn Val Asp Gly Leu Thr Ala Leu His Gln Ala 
65                  70                  75                  80  


Cys Ile Asp Asp Asn Val Asp Met Val Lys Phe Leu Val Glu Asn Gly 
                85                  90                  95      


Ala Asn Ile Asn Gln Pro Asp Asn Glu Gly Trp Ile Pro Leu His Ala 
            100                 105                 110         


Ala Ala Ser Cys Gly Tyr Leu Asp Ile Ala Glu Phe Leu Ile Gly Gln 
        115                 120                 125             


Gly Ala His Val Gly Ala Val Asn Ser Glu Gly Asp Thr Pro Leu Asp 
    130                 135                 140                 


Ile Ala Glu Glu Glu Ala Met Glu Glu Leu Leu Gln Asn Glu Val Asn 
145                 150                 155                 160 


Arg Gln Gly Val Asp Ile Glu Ala Ala Arg Lys Glu Glu Glu Arg Ile 
                165                 170                 175     


Met Leu Arg Asp Ala Arg Gln Trp Leu Asn Ser Gly His Ile Asn Asp 
            180                 185                 190         


Val Arg His Ala Lys Ser Gly Gly Thr Ala Leu His Val Ala Ala Ala 
        195                 200                 205             


Lys Gly Tyr Thr Glu Val Leu Lys Leu Leu Ile Gln Ala Gly Tyr Asp 
    210                 215                 220                 


Val Asn Ile Lys Asp Tyr Asp Gly Trp Thr Pro Leu His Ala Ala Ala 
225                 230                 235                 240 


His Trp Gly Lys Glu Glu Ala Cys Arg Ile Leu Val Asp Asn Leu Cys 
                245                 250                 255     


Asp Met Glu Met Val Asn Lys Val Gly Gln Thr Ala Phe Asp Val Ala 
            260                 265                 270         


Asp Glu Asp Ile Leu Gly Tyr Leu Glu Glu Leu Gln Lys Lys Gln Asn 
        275                 280                 285             


Leu Leu His Ser Glu Lys Arg Asp Lys Lys Ser Pro Leu Ile Glu Ser 
    290                 295                 300                 


Thr Ala Asn Met Asp Asn Asn Gln Ser Gln Lys Thr Phe Lys Asn Lys 
305                 310                 315                 320 


Glu Thr Leu Ile Ile Glu Pro Glu Lys Asn Ala Ser Arg Ile Glu Ser 
                325                 330                 335     


Leu Glu Gln Glu Lys Val Asp Glu Glu Glu Glu Gly Lys Lys Asp Glu 
            340                 345                 350         


Ser Ser Cys Ser Ser Glu Glu Asp Glu Glu Asp Asp Ser Glu Ser Glu 
        355                 360                 365             


Ala Glu Thr Asp Lys Thr Lys Pro Leu Ala Ser Val Thr Asn Ala Asn 
    370                 375                 380                 


Thr Ser Ser Thr Gln Ala Ala Pro Val Ala Val Thr Thr Pro Thr Val 
385                 390                 395                 400 


Ser Ser Gly Gln Ala Thr Pro Thr Ser Pro Ile Lys Lys Phe Pro Thr 
                405                 410                 415     


Thr Ala Thr Lys Ile Ser Pro Lys Glu Glu Glu Arg Lys Asp Glu Ser 
            420                 425                 430         


Pro Ala Thr Trp Arg Leu Gly Leu Arg Lys Thr Gly Ser Tyr Gly Ala 
        435                 440                 445             


Leu Ala Glu Ile Thr Ala Ser Lys Glu Gly Gln Lys Glu Lys Asp Thr 
    450                 455                 460                 


Ala Gly Val Thr Arg Ser Ala Ser Ser Pro Arg Leu Ser Ser Ser Leu 
465                 470                 475                 480 


Asp Asn Lys Glu Lys Glu Lys Asp Ser Lys Gly Thr Arg Leu Ala Tyr 
                485                 490                 495     


Val Ala Pro Thr Ile Pro Arg Arg Leu Ala Ser Thr Ser Asp Ile Glu 
            500                 505                 510         


Glu Lys Glu Asn Arg Asp Ser Ser Ser Leu Arg Thr Ser Ser Ser Tyr 
        515                 520                 525             


Thr Arg Arg Lys Trp Glu Asp Asp Leu Lys Lys Asn Ser Ser Val Asn 
    530                 535                 540                 


Glu Gly Ser Thr Tyr His Lys Ser Cys Ser Phe Gly Arg Arg Gln Asp 
545                 550                 555                 560 


Asp Leu Ile Ser Ser Ser Val Pro Ser Thr Thr Ser Thr Pro Thr Val 
                565                 570                 575     


Thr Ser Ala Ala Gly Leu Gln Lys Ser Leu Leu Ser Ser Thr Ser Thr 
            580                 585                 590         


Thr Thr Lys Ile Thr Thr Gly Ser Ser Ser Ala Gly Thr Gln Ser Ser 
        595                 600                 605             


Thr Ser Asn Arg Leu Trp Ala Glu Asp Ser Thr Glu Lys Glu Lys Asp 
    610                 615                 620                 


Ser Val Pro Thr Ala Val Thr Ile Pro Val Ala Pro Thr Val Val Asn 
625                 630                 635                 640 


Ala Ala Ala Ser Thr Thr Thr Leu Thr Thr Thr Thr Ala Gly Thr Val 
                645                 650                 655     


Ser Ser Thr Thr Glu Val Arg Glu Arg Arg Arg Ser Tyr Leu Thr Pro 
            660                 665                 670         


Val Arg Asp Glu Glu Ser Glu Ser Gln Arg Lys Ala Arg Ser Arg Gln 
        675                 680                 685             


Ala Arg Gln Ser Arg Arg Ser Thr Gln Gly Val Thr Leu Thr Asp Leu 
    690                 695                 700                 


Gln Glu Ala Glu Lys Thr Ile Gly Arg Ser Arg Ser Thr Arg Thr Arg 
705                 710                 715                 720 


Glu Gln Glu Asn Glu Glu Lys Glu Lys Glu Glu Lys Glu Lys Gln Asp 
                725                 730                 735     


Lys Glu Lys Gln Glu Glu Lys Lys Glu Ser Glu Thr Ser Arg Glu Asp 
            740                 745                 750         


Glu Tyr Lys Gln Lys Tyr Ser Arg Thr Tyr Asp Glu Thr Tyr Gln Arg 
        755                 760                 765             


Tyr Arg Pro Val Ser Thr Ser Ser Ser Thr Thr Pro Ser Ser Ser Leu 
    770                 775                 780                 


Ser Thr Met Ser Ser Ser Leu Tyr Ala Ser Ser Gln Leu Asn Arg Pro 
785                 790                 795                 800 


Asn Ser Leu Val Gly Ile Thr Ser Ala Tyr Ser Arg Gly Ile Thr Lys 
                805                 810                 815     


Glu Asn Glu Arg Glu Gly Glu Lys Arg Glu Glu Glu Lys Glu Gly Glu 
            820                 825                 830         


Asp Lys Ser Gln Pro Lys Ser Ile Arg Glu Arg Arg Arg Pro Arg Glu 
        835                 840                 845             


Lys Arg Arg Ser Thr Gly Val Ser Phe Trp Thr Gln Asp Ser Asp Glu 
    850                 855                 860                 


Asn Glu Gln Glu Gln Gln Ser Asp Thr Glu Glu Gly Ser Asn Lys Lys 
865                 870                 875                 880 


Glu Thr Gln Thr Asp Ser Ile Ser Arg Tyr Glu Thr Ser Ser Thr Ser 
                885                 890                 895     


Ala Gly Asp Arg Tyr Asp Ser Leu Leu Gly Arg Ser Gly Ser Tyr Ser 
            900                 905                 910         


Tyr Leu Glu Glu Arg Lys Pro Tyr Ser Ser Arg Leu Glu Lys Asp Asp 
        915                 920                 925             


Ser Thr Asp Phe Lys Lys Leu Tyr Glu Gln Ile Leu Ala Glu Asn Glu 
    930                 935                 940                 


Lys Leu Lys Ala Gln Leu His Asp Thr Asn Met Glu Leu Thr Asp Leu 
945                 950                 955                 960 


Lys Leu Gln Leu Glu Lys Ala Thr Gln Arg Gln Glu Arg Phe Ala Asp 
                965                 970                 975     


Arg Ser Leu Leu Glu Met Glu Lys Arg Glu Arg Arg Ala Leu Glu Arg 
            980                 985                 990         


Arg Ile Ser Glu Met Glu Glu Glu  Leu Lys Met Leu Pro  Asp Leu Lys 
        995                 1000                 1005             


Ala Asp  Asn Gln Arg Leu Lys  Asp Glu Asn Gly Ala  Leu Ile Arg 
    1010                 1015                 1020             


Val Ile  Ser Lys Leu Ser Lys  
    1025                 1030 


<210>  165
<211>  1146
<212>  DNA
<213>  Homo sapiens

<400>  165
atggagtctg gcagtaccgc cgccagtgag gaggcacgca gccttcgaga atgtgagctc       60

tacgtccaga agcataacat tcaagcgctg ctcaaagatt ctattgtgca gttgtgcact      120

gctcgacctg agagacccat ggcattcctc agggaatact ttgagaggtt ggagaaggag      180

gaggcaaaac agattcagaa tctgcagaaa gcaggcactc gtacagactc aagggaggat      240

gagatttctc ctcctccacc caacccagtg gttaaaggta ggaggcgacg aggtgctatc      300

agcgctgagg tctacacgga ggaagatgcg gcatcctatg ttagaaaggt tataccaaaa      360

gattacaaga caatggccgc tttagccaaa gccattgaaa agaatgtgct gttttcacat      420

cttgatgata atgagagaag tgatattttt gatgccatgt tttcggtctc ctttatcgca      480

ggagagactg tgattcagca aggtgatgaa ggggataact tctatgtgat tgatcaagga      540

gagacggatg tctatgttaa caatgaatgg gcaaccagtg ttggggaagg agggagcttt      600

ggagaacttg ctttgattta tggaacaccg agagcagcca ctgtcaaagc aaagacaaat      660

gtgaaattgt ggggcatcga ccgagacagc tatagaagaa tcctcatggg aagcacactg      720

agaaagcgga agatgtatga ggaattcctt agtaaagtct ctattttaga gtctctggac      780

aagtgggaac gtcttacggt agctgatgca ttggaaccag tgcagtttga agatgggcag      840

aagattgtgg tgcagggaga accaggggat gagttcttca ttattttaga ggggtcagct      900

gctgtgctac aacgtcggtc agaaaatgaa gagtttgttg aagtgggaag attggggcct      960

tctgattatt ttggtgaaat tgcactactg atgaatcgtc ctcgtgctgc cacagttgtt     1020

gctcgtggcc ccttgaagtg cgttaagctg gaccgaccta gatttgaacg tgttcttggc     1080

ccatgctcag acatcctcaa acgaaacatc cagcagtaca acagttttgt gtcactgtct     1140

gtctga                                                                1146


<210>  166
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  166

Met Glu Ser Gly Ser Thr Ala Ala Ser Glu Glu Ala Arg Ser Leu Arg 
1               5                   10                  15      


Glu Cys Glu Leu Tyr Val Gln Lys His Asn Ile Gln Ala Leu Leu Lys 
            20                  25                  30          


Asp Ser Ile Val Gln Leu Cys Thr Ala Arg Pro Glu Arg Pro Met Ala 
        35                  40                  45              


Phe Leu Arg Glu Tyr Phe Glu Arg Leu Glu Lys Glu Glu Ala Lys Gln 
    50                  55                  60                  


Ile Gln Asn Leu Gln Lys Ala Gly Thr Arg Thr Asp Ser Arg Glu Asp 
65                  70                  75                  80  


Glu Ile Ser Pro Pro Pro Pro Asn Pro Val Val Lys Gly Arg Arg Arg 
                85                  90                  95      


Arg Gly Ala Ile Ser Ala Glu Val Tyr Thr Glu Glu Asp Ala Ala Ser 
            100                 105                 110         


Tyr Val Arg Lys Val Ile Pro Lys Asp Tyr Lys Thr Met Ala Ala Leu 
        115                 120                 125             


Ala Lys Ala Ile Glu Lys Asn Val Leu Phe Ser His Leu Asp Asp Asn 
    130                 135                 140                 


Glu Arg Ser Asp Ile Phe Asp Ala Met Phe Ser Val Ser Phe Ile Ala 
145                 150                 155                 160 


Gly Glu Thr Val Ile Gln Gln Gly Asp Glu Gly Asp Asn Phe Tyr Val 
                165                 170                 175     


Ile Asp Gln Gly Glu Thr Asp Val Tyr Val Asn Asn Glu Trp Ala Thr 
            180                 185                 190         


Ser Val Gly Glu Gly Gly Ser Phe Gly Glu Leu Ala Leu Ile Tyr Gly 
        195                 200                 205             


Thr Pro Arg Ala Ala Thr Val Lys Ala Lys Thr Asn Val Lys Leu Trp 
    210                 215                 220                 


Gly Ile Asp Arg Asp Ser Tyr Arg Arg Ile Leu Met Gly Ser Thr Leu 
225                 230                 235                 240 


Arg Lys Arg Lys Met Tyr Glu Glu Phe Leu Ser Lys Val Ser Ile Leu 
                245                 250                 255     


Glu Ser Leu Asp Lys Trp Glu Arg Leu Thr Val Ala Asp Ala Leu Glu 
            260                 265                 270         


Pro Val Gln Phe Glu Asp Gly Gln Lys Ile Val Val Gln Gly Glu Pro 
        275                 280                 285             


Gly Asp Glu Phe Phe Ile Ile Leu Glu Gly Ser Ala Ala Val Leu Gln 
    290                 295                 300                 


Arg Arg Ser Glu Asn Glu Glu Phe Val Glu Val Gly Arg Leu Gly Pro 
305                 310                 315                 320 


Ser Asp Tyr Phe Gly Glu Ile Ala Leu Leu Met Asn Arg Pro Arg Ala 
                325                 330                 335     


Ala Thr Val Val Ala Arg Gly Pro Leu Lys Cys Val Lys Leu Asp Arg 
            340                 345                 350         


Pro Arg Phe Glu Arg Val Leu Gly Pro Cys Ser Asp Ile Leu Lys Arg 
        355                 360                 365             


Asn Ile Gln Gln Tyr Asn Ser Phe Val Ser Leu Ser Val 
    370                 375                 380     


<210>  167
<211>  1257
<212>  DNA
<213>  Homo sapiens

<400>  167
atgagcatcg agatcccggc gggactgacg gagctgctgc agggcttcac ggtggaggtg       60

ctgaggcacc agcccgcgga cctgctggag ttcgcgctgc agcacttcac ccgcctgcag      120

caggagaacg agcgcaaagg caccgcgcgc ttcggccatg agggcaggac ctggggggac      180

ctgggcgccg ctgccggggg cggcaccccc agcaaggggg tcaacttcgc cgaggagccc      240

atgcagtccg actccgagga cggggaggag gaggaggcgg cgcccgcgga cgcaggggcg      300

ttcaatgctc cagtaataaa ccgattcaca aggcgtgcct cagtatgtgc agaagcttat      360

aatcctgatg aagaagaaga tgatgcagag tccaggatta tacatccaaa aactgatgat      420

caaagaaata ggttgcaaga ggcttgcaaa gacatcctgc tgtttaagaa tctggatccg      480

gagcagatgt ctcaagtatt agatgccatg tttgaaaaat tggtcaaaga tggggagcat      540

gtaattgatc aaggtgacga tggtgacaac ttttatgtaa ttgatagagg cacatttgat      600

atttatgtga aatgtgatgg tgttggaaga tgtgttggta actatgataa tcgtgggagt      660

ttcggcgaac tggccttaat gtacaataca cccagagcag ctacaatcac tgctacctct      720

cctggtgctc tgtggggttt ggacagggta accttcagga gaataattgt gaaaaacaat      780

gccaaaaaga gaaaaatgta tgaaagcttt attgagtcac tgccattcct taaatctttg      840

gagttttctg aacgcctgaa agtagtagat gtgataggca ccaaagtata caacgatgga      900

gaacaaatca ttgctcaggg agattcggct gattcttttt tcattgtaga atctggagaa      960

gtgaaaatta ctatgaaaag aaagggtaaa tcagaagtgg aagagaatgg tgcagtagaa     1020

atcgctcgat gctcgcgggg acagtacttt ggagagcttg ccctggtaac taacaaacct     1080

cgagcagctt ctgcccacgc cattgggact gtcaaatgtt tagcaatgga tgtgcaagca     1140

tttgaaaggc ttctgggacc ttgcatggaa attatgaaaa ggaacatcgc tacctatgaa     1200

gaacagttag ttgccctgtt tggaacgaac atggatattg ttgaacccac tgcatga        1257


<210>  168
<211>  418
<212>  PRT
<213>  Homo sapiens

<400>  168

Met Ser Ile Glu Ile Pro Ala Gly Leu Thr Glu Leu Leu Gln Gly Phe 
1               5                   10                  15      


Thr Val Glu Val Leu Arg His Gln Pro Ala Asp Leu Leu Glu Phe Ala 
            20                  25                  30          


Leu Gln His Phe Thr Arg Leu Gln Gln Glu Asn Glu Arg Lys Gly Thr 
        35                  40                  45              


Ala Arg Phe Gly His Glu Gly Arg Thr Trp Gly Asp Leu Gly Ala Ala 
    50                  55                  60                  


Ala Gly Gly Gly Thr Pro Ser Lys Gly Val Asn Phe Ala Glu Glu Pro 
65                  70                  75                  80  


Met Gln Ser Asp Ser Glu Asp Gly Glu Glu Glu Glu Ala Ala Pro Ala 
                85                  90                  95      


Asp Ala Gly Ala Phe Asn Ala Pro Val Ile Asn Arg Phe Thr Arg Arg 
            100                 105                 110         


Ala Ser Val Cys Ala Glu Ala Tyr Asn Pro Asp Glu Glu Glu Asp Asp 
        115                 120                 125             


Ala Glu Ser Arg Ile Ile His Pro Lys Thr Asp Asp Gln Arg Asn Arg 
    130                 135                 140                 


Leu Gln Glu Ala Cys Lys Asp Ile Leu Leu Phe Lys Asn Leu Asp Pro 
145                 150                 155                 160 


Glu Gln Met Ser Gln Val Leu Asp Ala Met Phe Glu Lys Leu Val Lys 
                165                 170                 175     


Asp Gly Glu His Val Ile Asp Gln Gly Asp Asp Gly Asp Asn Phe Tyr 
            180                 185                 190         


Val Ile Asp Arg Gly Thr Phe Asp Ile Tyr Val Lys Cys Asp Gly Val 
        195                 200                 205             


Gly Arg Cys Val Gly Asn Tyr Asp Asn Arg Gly Ser Phe Gly Glu Leu 
    210                 215                 220                 


Ala Leu Met Tyr Asn Thr Pro Arg Ala Ala Thr Ile Thr Ala Thr Ser 
225                 230                 235                 240 


Pro Gly Ala Leu Trp Gly Leu Asp Arg Val Thr Phe Arg Arg Ile Ile 
                245                 250                 255     


Val Lys Asn Asn Ala Lys Lys Arg Lys Met Tyr Glu Ser Phe Ile Glu 
            260                 265                 270         


Ser Leu Pro Phe Leu Lys Ser Leu Glu Phe Ser Glu Arg Leu Lys Val 
        275                 280                 285             


Val Asp Val Ile Gly Thr Lys Val Tyr Asn Asp Gly Glu Gln Ile Ile 
    290                 295                 300                 


Ala Gln Gly Asp Ser Ala Asp Ser Phe Phe Ile Val Glu Ser Gly Glu 
305                 310                 315                 320 


Val Lys Ile Thr Met Lys Arg Lys Gly Lys Ser Glu Val Glu Glu Asn 
                325                 330                 335     


Gly Ala Val Glu Ile Ala Arg Cys Ser Arg Gly Gln Tyr Phe Gly Glu 
            340                 345                 350         


Leu Ala Leu Val Thr Asn Lys Pro Arg Ala Ala Ser Ala His Ala Ile 
        355                 360                 365             


Gly Thr Val Lys Cys Leu Ala Met Asp Val Gln Ala Phe Glu Arg Leu 
    370                 375                 380                 


Leu Gly Pro Cys Met Glu Ile Met Lys Arg Asn Ile Ala Thr Tyr Glu 
385                 390                 395                 400 


Glu Gln Leu Val Ala Leu Phe Gly Thr Asn Met Asp Ile Val Glu Pro 
                405                 410                 415     


Thr Ala 
        


<210>  169
<211>  2016
<212>  DNA
<213>  Homo sapiens

<400>  169
atggctgacc cggctgcggg gccgccgccg agcgagggcg aggagagcac cgtgcgcttc       60

gcccgcaaag gcgccctccg gcagaagaac gtgcatgagg tcaagaacca caaattcacc      120

gcccgcttct tcaagcagcc caccttctgc agccactgca ccgacttcat ctggggcttc      180

gggaagcagg gattccagtg ccaagtttgc tgctttgtgg tgcacaagcg gtgccatgaa      240

tttgtcacat tctcctgccc tggcgctgac aagggtccag cctccgatga cccccgcagc      300

aaacacaagt ttaagatcca cacgtactcc agccccacgt tttgtgacca ctgtgggtca      360

ctgctgtatg gactcatcca ccaggggatg aaatgtgaca cctgcatgat gaatgtgcac      420

aagcgctgcg tgatgaatgt tcccagcctg tgtggcacgg accacacgga gcgccgcggc      480

cgcatctaca tccaggccca catcgacagg gacgtcctca ttgtcctcgt aagagatgct      540

aaaaaccttg tacctatgga ccccaatggc ctgtcagatc cctacgtaaa actgaaactg      600

attcccgatc ccaaaagtga gagcaaacag aagaccaaaa ccatcaaatg ctccctcaac      660

cctgagtgga atgagacatt tagatttcag ctgaaagaat cggacaaaga cagaagactg      720

tcagtagaga tttgggattg ggatttgacc agcaggaatg acttcatggg atctttgtcc      780

tttgggattt ctgaacttca gaaagccagt gttgatggct ggtttaagtt actgagccag      840

gaggaaggcg agtacttcaa tgtgcctgtg ccaccagaag gaagtgaggc caatgaagaa      900

ctgcggcaga aatttgagag ggccaagatc agtcagggaa ccaaggtccc ggaagaaaag      960

acgaccaaca ctgtctccaa atttgacaac aatggcaaca gagaccggat gaaactgacc     1020

gattttaact tcctaatggt gctggggaaa ggcagctttg gcaaggtcat gctttcagaa     1080

cgaaaaggca cagatgagct ctatgctgtg aagatcctga agaaggacgt tgtgatccaa     1140

gatgatgacg tggagtgcac tatggtggag aagcgggtgt tggccctgcc tgggaagccg     1200

cccttcctga cccagctcca ctcctgcttc cagaccatgg accgcctgta ctttgtgatg     1260

gagtacgtga atgggggcga cctcatgtat cacatccagc aagtcggccg gttcaaggag     1320

ccccatgctg tattttacgc tgcagaaatt gccatcggtc tgttcttctt acagagtaag     1380

ggcatcattt accgtgacct aaaacttgac aacgtgatgc tcgattctga gggacacatc     1440

aagattgccg attttggcat gtgtaaggaa aacatctggg atggggtgac aaccaagaca     1500

ttctgtggca ctccagacta catcgccccc gagataattg cttatcagcc ctatgggaag     1560

tccgtggatt ggtgggcatt tggagtcctg ctgtatgaaa tgttggctgg gcaggcaccc     1620

tttgaagggg aggatgaaga tgaactcttc caatccatca tggaacacaa cgtagcctat     1680

cccaagtcta tgtccaagga agctgtggcc atctgcaaag ggctgatgac caaacaccca     1740

ggcaaacgtc tgggttgtgg acctgaaggc gaacgtgata tcaaagagca tgcatttttc     1800

cggtatattg attgggagaa acttgaacgc aaagagatcc agccccctta taagccaaaa     1860

gctagagaca agagagacac ctccaacttc gacaaagagt tcaccagaca gcctgtggaa     1920

ctgaccccca ctgataaact cttcatcatg aacttggacc aaaatgaatt tgctggcttc     1980

tcttatacta acccagagtt tgtcattaat gtgtag                               2016


<210>  170
<211>  671
<212>  PRT
<213>  Homo sapiens

<400>  170

Met Ala Asp Pro Ala Ala Gly Pro Pro Pro Ser Glu Gly Glu Glu Ser 
1               5                   10                  15      


Thr Val Arg Phe Ala Arg Lys Gly Ala Leu Arg Gln Lys Asn Val His 
            20                  25                  30          


Glu Val Lys Asn His Lys Phe Thr Ala Arg Phe Phe Lys Gln Pro Thr 
        35                  40                  45              


Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly 
    50                  55                  60                  


Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu 
65                  70                  75                  80  


Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Ala Ser Asp 
                85                  90                  95      


Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Ser Ser Pro 
            100                 105                 110         


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln 
        115                 120                 125             


Gly Met Lys Cys Asp Thr Cys Met Met Asn Val His Lys Arg Cys Val 
    130                 135                 140                 


Met Asn Val Pro Ser Leu Cys Gly Thr Asp His Thr Glu Arg Arg Gly 
145                 150                 155                 160 


Arg Ile Tyr Ile Gln Ala His Ile Asp Arg Asp Val Leu Ile Val Leu 
                165                 170                 175     


Val Arg Asp Ala Lys Asn Leu Val Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Ser Glu Ser 
        195                 200                 205             


Lys Gln Lys Thr Lys Thr Ile Lys Cys Ser Leu Asn Pro Glu Trp Asn 
    210                 215                 220                 


Glu Thr Phe Arg Phe Gln Leu Lys Glu Ser Asp Lys Asp Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Ile Trp Asp Trp Asp Leu Thr Ser Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ser Leu Ser Phe Gly Ile Ser Glu Leu Gln Lys Ala Ser Val Asp 
            260                 265                 270         


Gly Trp Phe Lys Leu Leu Ser Gln Glu Glu Gly Glu Tyr Phe Asn Val 
        275                 280                 285             


Pro Val Pro Pro Glu Gly Ser Glu Ala Asn Glu Glu Leu Arg Gln Lys 
    290                 295                 300                 


Phe Glu Arg Ala Lys Ile Ser Gln Gly Thr Lys Val Pro Glu Glu Lys 
305                 310                 315                 320 


Thr Thr Asn Thr Val Ser Lys Phe Asp Asn Asn Gly Asn Arg Asp Arg 
                325                 330                 335     


Met Lys Leu Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser 
            340                 345                 350         


Phe Gly Lys Val Met Leu Ser Glu Arg Lys Gly Thr Asp Glu Leu Tyr 
        355                 360                 365             


Ala Val Lys Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val 
    370                 375                 380                 


Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala Leu Pro Gly Lys Pro 
385                 390                 395                 400 


Pro Phe Leu Thr Gln Leu His Ser Cys Phe Gln Thr Met Asp Arg Leu 
                405                 410                 415     


Tyr Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile 
            420                 425                 430         


Gln Gln Val Gly Arg Phe Lys Glu Pro His Ala Val Phe Tyr Ala Ala 
        435                 440                 445             


Glu Ile Ala Ile Gly Leu Phe Phe Leu Gln Ser Lys Gly Ile Ile Tyr 
    450                 455                 460                 


Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile 
465                 470                 475                 480 


Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn Ile Trp Asp Gly Val 
                485                 490                 495     


Thr Thr Lys Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile 
            500                 505                 510         


Ile Ala Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Phe Gly 
        515                 520                 525             


Val Leu Leu Tyr Glu Met Leu Ala Gly Gln Ala Pro Phe Glu Gly Glu 
    530                 535                 540                 


Asp Glu Asp Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ala Tyr 
545                 550                 555                 560 


Pro Lys Ser Met Ser Lys Glu Ala Val Ala Ile Cys Lys Gly Leu Met 
                565                 570                 575     


Thr Lys His Pro Gly Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg 
            580                 585                 590         


Asp Ile Lys Glu His Ala Phe Phe Arg Tyr Ile Asp Trp Glu Lys Leu 
        595                 600                 605             


Glu Arg Lys Glu Ile Gln Pro Pro Tyr Lys Pro Lys Ala Arg Asp Lys 
    610                 615                 620                 


Arg Asp Thr Ser Asn Phe Asp Lys Glu Phe Thr Arg Gln Pro Val Glu 
625                 630                 635                 640 


Leu Thr Pro Thr Asp Lys Leu Phe Ile Met Asn Leu Asp Gln Asn Glu 
                645                 650                 655     


Phe Ala Gly Phe Ser Tyr Thr Asn Pro Glu Phe Val Ile Asn Val 
            660                 665                 670     


<210>  171
<211>  1032
<212>  DNA
<213>  Homo sapiens

<400>  171
atggcccaga agggggtcct ggggcctggg cagctggggg ctgtggccat tctgctctat       60

cttggattac tccggtcggg gacaggagcg gaaggggcag aagctccctg cggtgtggcc      120

ccccaagcac gcatcacagg tggcagcagt gcagtcgccg gtcagtggcc ctggcaggtc      180

agcatcacct atgaaggcgt ccatgtgtgt ggtggctctc tcgtgtctga gcagtgggtg      240

ctgtcagctg ctcactgctt ccccagcgag caccacaagg aagcctatga ggtcaagctg      300

ggggcccacc agctagactc ctactccgag gacgccaagg tcagcaccct gaaggacatc      360

atcccccacc ccagctacct ccaggagggc tcccagggcg acattgcact cctccaactc      420

agcagaccca tcaccttctc ccgctacatc cggcccatct gcctccctgc agccaacgcc      480

tccttcccca acggcctcca ctgcactgtc actggctggg gtcatgtggc cccctcagtg      540

agcctcctga cgcccaagcc actgcagcaa ctcgaggtgc ctctgatcag tcgtgagacg      600

tgtaactgcc tgtacaacat cgacgccaag cctgaggagc cgcactttgt ccaagaggac      660

atggtgtgtg ctggctatgt ggaggggggc aaggacgcct gccagggtga ctctgggggc      720

ccactctcct gccctgtgga gggtctctgg tacctgacgg gcattgtgag ctggggagat      780

gcctgtgggg cccgcaacag gcctggtgtg tacactctgg cctccagcta tgcctcctgg      840

atccaaagca aggtgacaga actccagcct cgtgtggtgc cccaaaccca ggagtcccag      900

cccgacagca acctctgtgg cagccacctg gccttcagct ctgccccagc ccagggcttg      960

ctgaggccca tccttttcct gcctctgggc ctggctctgg gcctcctctc cccatggctc     1020

agcgagcact ga                                                         1032


<210>  172
<211>  343
<212>  PRT
<213>  Homo sapiens

<400>  172

Met Ala Gln Lys Gly Val Leu Gly Pro Gly Gln Leu Gly Ala Val Ala 
1               5                   10                  15      


Ile Leu Leu Tyr Leu Gly Leu Leu Arg Ser Gly Thr Gly Ala Glu Gly 
            20                  25                  30          


Ala Glu Ala Pro Cys Gly Val Ala Pro Gln Ala Arg Ile Thr Gly Gly 
        35                  40                  45              


Ser Ser Ala Val Ala Gly Gln Trp Pro Trp Gln Val Ser Ile Thr Tyr 
    50                  55                  60                  


Glu Gly Val His Val Cys Gly Gly Ser Leu Val Ser Glu Gln Trp Val 
65                  70                  75                  80  


Leu Ser Ala Ala His Cys Phe Pro Ser Glu His His Lys Glu Ala Tyr 
                85                  90                  95      


Glu Val Lys Leu Gly Ala His Gln Leu Asp Ser Tyr Ser Glu Asp Ala 
            100                 105                 110         


Lys Val Ser Thr Leu Lys Asp Ile Ile Pro His Pro Ser Tyr Leu Gln 
        115                 120                 125             


Glu Gly Ser Gln Gly Asp Ile Ala Leu Leu Gln Leu Ser Arg Pro Ile 
    130                 135                 140                 


Thr Phe Ser Arg Tyr Ile Arg Pro Ile Cys Leu Pro Ala Ala Asn Ala 
145                 150                 155                 160 


Ser Phe Pro Asn Gly Leu His Cys Thr Val Thr Gly Trp Gly His Val 
                165                 170                 175     


Ala Pro Ser Val Ser Leu Leu Thr Pro Lys Pro Leu Gln Gln Leu Glu 
            180                 185                 190         


Val Pro Leu Ile Ser Arg Glu Thr Cys Asn Cys Leu Tyr Asn Ile Asp 
        195                 200                 205             


Ala Lys Pro Glu Glu Pro His Phe Val Gln Glu Asp Met Val Cys Ala 
    210                 215                 220                 


Gly Tyr Val Glu Gly Gly Lys Asp Ala Cys Gln Gly Asp Ser Gly Gly 
225                 230                 235                 240 


Pro Leu Ser Cys Pro Val Glu Gly Leu Trp Tyr Leu Thr Gly Ile Val 
                245                 250                 255     


Ser Trp Gly Asp Ala Cys Gly Ala Arg Asn Arg Pro Gly Val Tyr Thr 
            260                 265                 270         


Leu Ala Ser Ser Tyr Ala Ser Trp Ile Gln Ser Lys Val Thr Glu Leu 
        275                 280                 285             


Gln Pro Arg Val Val Pro Gln Thr Gln Glu Ser Gln Pro Asp Ser Asn 
    290                 295                 300                 


Leu Cys Gly Ser His Leu Ala Phe Ser Ser Ala Pro Ala Gln Gly Leu 
305                 310                 315                 320 


Leu Arg Pro Ile Leu Phe Leu Pro Leu Gly Leu Ala Leu Gly Leu Leu 
                325                 330                 335     


Ser Pro Trp Leu Ser Glu His 
            340             


<210>  173
<211>  1173
<212>  DNA
<213>  Homo sapiens

<400>  173
atggaggacc ccacgctcta tattgtcgag cggccgcttc ccgggtaccc cgacgccgag       60

gccccggagc cttcctccgc tggggctcag gcagcggagg agccgtcggg ggccggctca      120

gaagagctga tcaagtcgga ccaggtgaac ggcgtgctgg tgctgagcct cctggacaaa      180

atcatcgggg ccgtagacca gatccagctg actcaagcac agctggagga gcggcaggcg      240

gagatggagg gcgcagtgca gagcatccag ggcgagctga gcaagctggg caaggcgcac      300

gccaccacga gcaatacggt gagcaagctg ctggagaagg tgcgcaaggt cagcgtcaac      360

gtgaagaccg tgcgcggcag cctggagcgc caggcggggc agatcaagaa gctggaggtc      420

aacgaggccg agctgctgcg gcgccgcaac tttaaagtca tgatctacca ggatgaagtg      480

aagctgccgg ccaaactgag catcagcaaa tcgctgaaag agtcggaggc gctgccagag      540

aaggagggcg aggagctggg cgagggcgag cggcccgagg aggacgcagc ggcgctggag      600

ctttcgtcgg acgaggcggt ggaggttgag gaggttattg aggagtcccg cgcagagcgt      660

atcaagcgca gcggcctgcg gcgcgtggac gacttcaaga aggccttctc caaggagaag      720

atggagaaga ccaaggtgcg tacccgcgag aacctggaga agacgcgcct caagaccaag      780

gaaaacctgg agaagacgcg gcacaccctg gagaagcgca tgaacaagct gggcacgcgc      840

ctggtgcccg ccgagcggcg cgagaaactg aagacgtcgc gggacaagtt gcgcaaatcc      900

ttcacgcccg accacgtggt gtacgcgcgc tccaagaccg cggtctacaa ggtgccaccc      960

ttcaccttcc acgtcaagaa gatccgcgag ggccaggtgg aagtgctcaa ggccaccgag     1020

atggtggagg tgggcgccga cgacgacgag ggcggcgcgg agcgcgggga ggccggcgac     1080

ctgcggcgcg ggagcagccc cgacgtgcac gcgctgctgg agatcaccga ggagtcggac     1140

gccgtgctgg tggacaagag cgacagcgac tga                                  1173


<210>  174
<211>  390
<212>  PRT
<213>  Homo sapiens

<400>  174

Met Glu Asp Pro Thr Leu Tyr Ile Val Glu Arg Pro Leu Pro Gly Tyr 
1               5                   10                  15      


Pro Asp Ala Glu Ala Pro Glu Pro Ser Ser Ala Gly Ala Gln Ala Ala 
            20                  25                  30          


Glu Glu Pro Ser Gly Ala Gly Ser Glu Glu Leu Ile Lys Ser Asp Gln 
        35                  40                  45              


Val Asn Gly Val Leu Val Leu Ser Leu Leu Asp Lys Ile Ile Gly Ala 
    50                  55                  60                  


Val Asp Gln Ile Gln Leu Thr Gln Ala Gln Leu Glu Glu Arg Gln Ala 
65                  70                  75                  80  


Glu Met Glu Gly Ala Val Gln Ser Ile Gln Gly Glu Leu Ser Lys Leu 
                85                  90                  95      


Gly Lys Ala His Ala Thr Thr Ser Asn Thr Val Ser Lys Leu Leu Glu 
            100                 105                 110         


Lys Val Arg Lys Val Ser Val Asn Val Lys Thr Val Arg Gly Ser Leu 
        115                 120                 125             


Glu Arg Gln Ala Gly Gln Ile Lys Lys Leu Glu Val Asn Glu Ala Glu 
    130                 135                 140                 


Leu Leu Arg Arg Arg Asn Phe Lys Val Met Ile Tyr Gln Asp Glu Val 
145                 150                 155                 160 


Lys Leu Pro Ala Lys Leu Ser Ile Ser Lys Ser Leu Lys Glu Ser Glu 
                165                 170                 175     


Ala Leu Pro Glu Lys Glu Gly Glu Glu Leu Gly Glu Gly Glu Arg Pro 
            180                 185                 190         


Glu Glu Asp Ala Ala Ala Leu Glu Leu Ser Ser Asp Glu Ala Val Glu 
        195                 200                 205             


Val Glu Glu Val Ile Glu Glu Ser Arg Ala Glu Arg Ile Lys Arg Ser 
    210                 215                 220                 


Gly Leu Arg Arg Val Asp Asp Phe Lys Lys Ala Phe Ser Lys Glu Lys 
225                 230                 235                 240 


Met Glu Lys Thr Lys Val Arg Thr Arg Glu Asn Leu Glu Lys Thr Arg 
                245                 250                 255     


Leu Lys Thr Lys Glu Asn Leu Glu Lys Thr Arg His Thr Leu Glu Lys 
            260                 265                 270         


Arg Met Asn Lys Leu Gly Thr Arg Leu Val Pro Ala Glu Arg Arg Glu 
        275                 280                 285             


Lys Leu Lys Thr Ser Arg Asp Lys Leu Arg Lys Ser Phe Thr Pro Asp 
    290                 295                 300                 


His Val Val Tyr Ala Arg Ser Lys Thr Ala Val Tyr Lys Val Pro Pro 
305                 310                 315                 320 


Phe Thr Phe His Val Lys Lys Ile Arg Glu Gly Gln Val Glu Val Leu 
                325                 330                 335     


Lys Ala Thr Glu Met Val Glu Val Gly Ala Asp Asp Asp Glu Gly Gly 
            340                 345                 350         


Ala Glu Arg Gly Glu Ala Gly Asp Leu Arg Arg Gly Ser Ser Pro Asp 
        355                 360                 365             


Val His Ala Leu Leu Glu Ile Thr Glu Glu Ser Asp Ala Val Leu Val 
    370                 375                 380                 


Asp Lys Ser Asp Ser Asp 
385                 390 


<210>  175
<211>  651
<212>  DNA
<213>  Homo sapiens

<400>  175
atgggcaccc gcgacgacga gtacgactac ctctttaaag ttgtccttat tggagattct       60

ggtgttggaa agagtaatct cctgtctcga tttactcgaa atgagtttaa tctggaaagc      120

aagagcacca ttggagtaga gtttgcaaca agaagcatcc aggttgatgg aaaaacaata      180

aaggcacaga tatgggacac agcagggcaa gagcgatatc gagctataac atcagcatat      240

tatcgtggag ctgtaggtgc cttattggtt tatgacattg ctaaacatct cacatatgaa      300

aatgtagagc gatggctgaa agaactgaga gatcatgctg atagtaacat tgttatcatg      360

cttgtgggca ataagagtga tctacgtcat ctcagggcag ttcctacaga tgaagcaaga      420

gcttttgcag aaaagaatgg tttgtcattc attgaaactt cggccctaga ctctacaaat      480

gtagaagctg cttttcagac aattttaaca gagatttacc gcattgtttc tcagaagcaa      540

atgtcagaca gacgcgaaaa tgacatgtct ccaagcaaca atgtggttcc tattcatgtt      600

ccaccaacca ctgaaaacaa gccaaaggtg cagtgctgtc agaacatcta a               651


<210>  176
<211>  216
<212>  PRT
<213>  Homo sapiens

<400>  176

Met Gly Thr Arg Asp Asp Glu Tyr Asp Tyr Leu Phe Lys Val Val Leu 
1               5                   10                  15      


Ile Gly Asp Ser Gly Val Gly Lys Ser Asn Leu Leu Ser Arg Phe Thr 
            20                  25                  30          


Arg Asn Glu Phe Asn Leu Glu Ser Lys Ser Thr Ile Gly Val Glu Phe 
        35                  40                  45              


Ala Thr Arg Ser Ile Gln Val Asp Gly Lys Thr Ile Lys Ala Gln Ile 
    50                  55                  60                  


Trp Asp Thr Ala Gly Gln Glu Arg Tyr Arg Ala Ile Thr Ser Ala Tyr 
65                  70                  75                  80  


Tyr Arg Gly Ala Val Gly Ala Leu Leu Val Tyr Asp Ile Ala Lys His 
                85                  90                  95      


Leu Thr Tyr Glu Asn Val Glu Arg Trp Leu Lys Glu Leu Arg Asp His 
            100                 105                 110         


Ala Asp Ser Asn Ile Val Ile Met Leu Val Gly Asn Lys Ser Asp Leu 
        115                 120                 125             


Arg His Leu Arg Ala Val Pro Thr Asp Glu Ala Arg Ala Phe Ala Glu 
    130                 135                 140                 


Lys Asn Gly Leu Ser Phe Ile Glu Thr Ser Ala Leu Asp Ser Thr Asn 
145                 150                 155                 160 


Val Glu Ala Ala Phe Gln Thr Ile Leu Thr Glu Ile Tyr Arg Ile Val 
                165                 170                 175     


Ser Gln Lys Gln Met Ser Asp Arg Arg Glu Asn Asp Met Ser Pro Ser 
            180                 185                 190         


Asn Asn Val Val Pro Ile His Val Pro Pro Thr Thr Glu Asn Lys Pro 
        195                 200                 205             


Lys Val Gln Cys Cys Gln Asn Ile 
    210                 215     


<210>  177
<211>  666
<212>  DNA
<213>  Homo sapiens

<400>  177
atgtctgatg gagattatga ttacctcatc aagtttttag ctttgggaga ctctggtgta       60

gggaagacca gtgtacttta ccaatataca gatggtaaat ttaactccaa atttatcaca      120

acagtgggca ttgatttcag ggaaaaaaga gtggtgtaca gagccagtgg gccggatgga      180

gccactggca gaggccagag aatccacctg cagttatggg acacagcagg gcaggagagg      240

tttcgtagct taacgacagc gttcttcaga gatgctatgg gttttcttct actttttgat      300

ctgacaaatg agcaaagttt cctcaatgtc agaaactgga taagccagct acagatgcat      360

gcatattgtg aaaacccaga tatagtgctg tgtggaaaca agagtgatct ggaggaccag      420

agagtagtga aagaggagga agccatagca ctcgcagaga aatatggaat cccctacttt      480

gaaactagtg ctgccaatgg gacaaacata agccaagcaa ttgagatgct tctggacctg      540

ataatgaagc gaatggaacg gtgtgtggac aagtcctgga ttcctgaagg agtggtgcga      600

tcaaatggtc atgcctctac ggatcagtta agtgaagaaa aggagaaagg ggcatgtggc      660

tgttga                                                                 666


<210>  178
<211>  221
<212>  PRT
<213>  Homo sapiens

<400>  178

Met Ser Asp Gly Asp Tyr Asp Tyr Leu Ile Lys Phe Leu Ala Leu Gly 
1               5                   10                  15      


Asp Ser Gly Val Gly Lys Thr Ser Val Leu Tyr Gln Tyr Thr Asp Gly 
            20                  25                  30          


Lys Phe Asn Ser Lys Phe Ile Thr Thr Val Gly Ile Asp Phe Arg Glu 
        35                  40                  45              


Lys Arg Val Val Tyr Arg Ala Ser Gly Pro Asp Gly Ala Thr Gly Arg 
    50                  55                  60                  


Gly Gln Arg Ile His Leu Gln Leu Trp Asp Thr Ala Gly Gln Glu Arg 
65                  70                  75                  80  


Phe Arg Ser Leu Thr Thr Ala Phe Phe Arg Asp Ala Met Gly Phe Leu 
                85                  90                  95      


Leu Leu Phe Asp Leu Thr Asn Glu Gln Ser Phe Leu Asn Val Arg Asn 
            100                 105                 110         


Trp Ile Ser Gln Leu Gln Met His Ala Tyr Cys Glu Asn Pro Asp Ile 
        115                 120                 125             


Val Leu Cys Gly Asn Lys Ser Asp Leu Glu Asp Gln Arg Val Val Lys 
    130                 135                 140                 


Glu Glu Glu Ala Ile Ala Leu Ala Glu Lys Tyr Gly Ile Pro Tyr Phe 
145                 150                 155                 160 


Glu Thr Ser Ala Ala Asn Gly Thr Asn Ile Ser Gln Ala Ile Glu Met 
                165                 170                 175     


Leu Leu Asp Leu Ile Met Lys Arg Met Glu Arg Cys Val Asp Lys Ser 
            180                 185                 190         


Trp Ile Pro Glu Gly Val Val Arg Ser Asn Gly His Ala Ser Thr Asp 
        195                 200                 205             


Gln Leu Ser Glu Glu Lys Glu Lys Gly Ala Cys Gly Cys 
    210                 215                 220     


<210>  179
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  179
atgtccgaaa cctacgattt tttgtttaag ttcttggtta ttggaaatgc aggaactggc       60

aaatcttgct tacttcatca gtttattgaa aaaaaattca aagatgactc aaatcataca      120

ataggagtgg aatttggttc aaagataata aatgttggtg gtaaatatgt aaagttacaa      180

atatgggata cagcaggaca agaacgattc aggtccgtga cgagaagtta ttaccgaggc      240

gcggccgggg ctctcctcgt ctatgatatc accagccgag aaacctacaa tgcgcttact      300

aattggttaa cagatgcccg aatgctagcg agccagaaca ttgtgatcat cctttgtgga      360

aacaagaagg acctggatgc agatcgtgaa gttaccttct tagaagcctc cagatttgct      420

caagaaaatg agctgatgtt tttggaaaca agtgcgctca caggggaaga tgtagaagag      480

gcttttgtac agtgtgcaag aaaaatactt aacaaaatcg aatcaggtga gctggaccca      540

gaaagaatgg gctcaggtat tcagtacgga gatgctgcct tgagacagct gaggtcaccg      600

cggcgcaccc aggccccgaa cgctcaggag tgtggttgtt ag                         642


<210>  180
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  180

Met Ser Glu Thr Tyr Asp Phe Leu Phe Lys Phe Leu Val Ile Gly Asn 
1               5                   10                  15      


Ala Gly Thr Gly Lys Ser Cys Leu Leu His Gln Phe Ile Glu Lys Lys 
            20                  25                  30          


Phe Lys Asp Asp Ser Asn His Thr Ile Gly Val Glu Phe Gly Ser Lys 
        35                  40                  45              


Ile Ile Asn Val Gly Gly Lys Tyr Val Lys Leu Gln Ile Trp Asp Thr 
    50                  55                  60                  


Ala Gly Gln Glu Arg Phe Arg Ser Val Thr Arg Ser Tyr Tyr Arg Gly 
65                  70                  75                  80  


Ala Ala Gly Ala Leu Leu Val Tyr Asp Ile Thr Ser Arg Glu Thr Tyr 
                85                  90                  95      


Asn Ala Leu Thr Asn Trp Leu Thr Asp Ala Arg Met Leu Ala Ser Gln 
            100                 105                 110         


Asn Ile Val Ile Ile Leu Cys Gly Asn Lys Lys Asp Leu Asp Ala Asp 
        115                 120                 125             


Arg Glu Val Thr Phe Leu Glu Ala Ser Arg Phe Ala Gln Glu Asn Glu 
    130                 135                 140                 


Leu Met Phe Leu Glu Thr Ser Ala Leu Thr Gly Glu Asp Val Glu Glu 
145                 150                 155                 160 


Ala Phe Val Gln Cys Ala Arg Lys Ile Leu Asn Lys Ile Glu Ser Gly 
                165                 170                 175     


Glu Leu Asp Pro Glu Arg Met Gly Ser Gly Ile Gln Tyr Gly Asp Ala 
            180                 185                 190         


Ala Leu Arg Gln Leu Arg Ser Pro Arg Arg Thr Gln Ala Pro Asn Ala 
        195                 200                 205             


Gln Glu Cys Gly Cys 
    210             


<210>  181
<211>  621
<212>  DNA
<213>  Homo sapiens

<400>  181
atggctgcaa ataagcccaa gggtcagaat tctttggctt tacacaaagt catcatggtg       60

ggcagtggtg gcgtgggcaa gtcagctctg actctacagt tcatgtacga tgagtttgtg      120

gaggactatg agcctaccaa agcagacagc tatcggaaga aggtagtgct agatggggag      180

gaagtccaga tcgatatctt agatacagct gggcaggagg actacgctgc aattagagac      240

aactacttcc gaagtgggga ggggttcctc tgtgttttct ctattacaga aatggaatcc      300

tttgcagcta cagctgactt cagggagcag attttaagag taaaagaaga tgagaatgtt      360

ccatttctac tggttggtaa caaatcagat ttagaagata aaagacaggt ttctgtagaa      420

gaggcaaaaa acagagctga gcagtggaat gttaactacg tggaaacatc tgctaaaaca      480

cgagctaatg ttgacaaggt attttttgat ttaatgagag aaattcgagc gagaaagatg      540

gaagacagca aagaaaagaa tggaaaaaag aagaggaaaa gtttagccaa gagaatcaga      600

gaaagatgct gcattttata a                                                621


<210>  182
<211>  206
<212>  PRT
<213>  Homo sapiens

<400>  182

Met Ala Ala Asn Lys Pro Lys Gly Gln Asn Ser Leu Ala Leu His Lys 
1               5                   10                  15      


Val Ile Met Val Gly Ser Gly Gly Val Gly Lys Ser Ala Leu Thr Leu 
            20                  25                  30          


Gln Phe Met Tyr Asp Glu Phe Val Glu Asp Tyr Glu Pro Thr Lys Ala 
        35                  40                  45              


Asp Ser Tyr Arg Lys Lys Val Val Leu Asp Gly Glu Glu Val Gln Ile 
    50                  55                  60                  


Asp Ile Leu Asp Thr Ala Gly Gln Glu Asp Tyr Ala Ala Ile Arg Asp 
65                  70                  75                  80  


Asn Tyr Phe Arg Ser Gly Glu Gly Phe Leu Cys Val Phe Ser Ile Thr 
                85                  90                  95      


Glu Met Glu Ser Phe Ala Ala Thr Ala Asp Phe Arg Glu Gln Ile Leu 
            100                 105                 110         


Arg Val Lys Glu Asp Glu Asn Val Pro Phe Leu Leu Val Gly Asn Lys 
        115                 120                 125             


Ser Asp Leu Glu Asp Lys Arg Gln Val Ser Val Glu Glu Ala Lys Asn 
    130                 135                 140                 


Arg Ala Glu Gln Trp Asn Val Asn Tyr Val Glu Thr Ser Ala Lys Thr 
145                 150                 155                 160 


Arg Ala Asn Val Asp Lys Val Phe Phe Asp Leu Met Arg Glu Ile Arg 
                165                 170                 175     


Ala Arg Lys Met Glu Asp Ser Lys Glu Lys Asn Gly Lys Lys Lys Arg 
            180                 185                 190         


Lys Ser Leu Ala Lys Arg Ile Arg Glu Arg Cys Cys Ile Leu 
        195                 200                 205     


<210>  183
<211>  1278
<212>  DNA
<213>  Homo sapiens

<400>  183
atggccgaca aggaagcagc cttcgacgac gcagtggaag aacgagtgat caacgaggaa       60

tacaaaatat ggaaaaagaa cacccctttt ctttatgatt tggtgatgac ccatgctctg      120

gagtggccca gcctaactgc ccagtggctt ccagatgtaa ccagaccaga agggaaagat      180

ttcagcattc atcgacttgt cctggggaca cacacatcgg atgaacaaaa ccatcttgtt      240

atagccagtg tgcagctccc taatgatgat gctcagtttg atgcgtcaca ctacgacagt      300

gagaaaggag aatttggagg ttttggttca gttagtggaa aaattgaaat agaaatcaag      360

atcaaccatg aaggagaagt aaacagggcc cgttatatgc cccagaaccc ttgtatcatc      420

gcaacaaaga ctccttccag tgatgttctt gtttttgact atacaaaaca tccttctaaa      480

ccagatcctt ctggagagtg caacccagac ttgcgtctcc gtggacatca gaaggaaggc      540

tatgggcttt cttggaaccc aaatctcagt gggcacttac ttagtgcttc agatgaccat      600

accatctgcc tgtgggacat cagtgccgtt ccaaaggagg gaaaagtggt agatgcgaag      660

accatcttta cagggcatac ggcagtagta gaagatgttt cctggcatct actccatgag      720

tctctgtttg ggtcagttgc tgatgatcag aaacttatga tttgggatac tcgttcaaac      780

aatacttcca aaccaagcca ctcagttgat gctcacactg ctgaagtgaa ctgcctttct      840

ttcaatcctt atagtgagtt cattcttgcc acaggatcag ctgacaagac tgttgccttg      900

tgggatctga gaaatctgaa acttaagttg cattcctttg agtcacataa ggatgaaata      960

ttccaggttc agtggtcacc tcacaatgag actattttag cttccagtgg tactgatcgc     1020

agactgaatg tctgggattt aagtaaaatt ggagaggaac aatccccaga agatgcagaa     1080

gacgggccac cagagttgtt gtttattcat ggtggtcata ctgccaagat atctgatttc     1140

tcctggaatc ccaatgaacc ttgggtgatt tgttctgtat cagaagacaa tatcatgcaa     1200

gtgtggcaaa tggcagagaa catttataat gatgaagacc ctgaaggaag cgtggatcca     1260

gaaggacaag ggtcctag                                                   1278


<210>  184
<211>  425
<212>  PRT
<213>  Homo sapiens

<400>  184

Met Ala Asp Lys Glu Ala Ala Phe Asp Asp Ala Val Glu Glu Arg Val 
1               5                   10                  15      


Ile Asn Glu Glu Tyr Lys Ile Trp Lys Lys Asn Thr Pro Phe Leu Tyr 
            20                  25                  30          


Asp Leu Val Met Thr His Ala Leu Glu Trp Pro Ser Leu Thr Ala Gln 
        35                  40                  45              


Trp Leu Pro Asp Val Thr Arg Pro Glu Gly Lys Asp Phe Ser Ile His 
    50                  55                  60                  


Arg Leu Val Leu Gly Thr His Thr Ser Asp Glu Gln Asn His Leu Val 
65                  70                  75                  80  


Ile Ala Ser Val Gln Leu Pro Asn Asp Asp Ala Gln Phe Asp Ala Ser 
                85                  90                  95      


His Tyr Asp Ser Glu Lys Gly Glu Phe Gly Gly Phe Gly Ser Val Ser 
            100                 105                 110         


Gly Lys Ile Glu Ile Glu Ile Lys Ile Asn His Glu Gly Glu Val Asn 
        115                 120                 125             


Arg Ala Arg Tyr Met Pro Gln Asn Pro Cys Ile Ile Ala Thr Lys Thr 
    130                 135                 140                 


Pro Ser Ser Asp Val Leu Val Phe Asp Tyr Thr Lys His Pro Ser Lys 
145                 150                 155                 160 


Pro Asp Pro Ser Gly Glu Cys Asn Pro Asp Leu Arg Leu Arg Gly His 
                165                 170                 175     


Gln Lys Glu Gly Tyr Gly Leu Ser Trp Asn Pro Asn Leu Ser Gly His 
            180                 185                 190         


Leu Leu Ser Ala Ser Asp Asp His Thr Ile Cys Leu Trp Asp Ile Ser 
        195                 200                 205             


Ala Val Pro Lys Glu Gly Lys Val Val Asp Ala Lys Thr Ile Phe Thr 
    210                 215                 220                 


Gly His Thr Ala Val Val Glu Asp Val Ser Trp His Leu Leu His Glu 
225                 230                 235                 240 


Ser Leu Phe Gly Ser Val Ala Asp Asp Gln Lys Leu Met Ile Trp Asp 
                245                 250                 255     


Thr Arg Ser Asn Asn Thr Ser Lys Pro Ser His Ser Val Asp Ala His 
            260                 265                 270         


Thr Ala Glu Val Asn Cys Leu Ser Phe Asn Pro Tyr Ser Glu Phe Ile 
        275                 280                 285             


Leu Ala Thr Gly Ser Ala Asp Lys Thr Val Ala Leu Trp Asp Leu Arg 
    290                 295                 300                 


Asn Leu Lys Leu Lys Leu His Ser Phe Glu Ser His Lys Asp Glu Ile 
305                 310                 315                 320 


Phe Gln Val Gln Trp Ser Pro His Asn Glu Thr Ile Leu Ala Ser Ser 
                325                 330                 335     


Gly Thr Asp Arg Arg Leu Asn Val Trp Asp Leu Ser Lys Ile Gly Glu 
            340                 345                 350         


Glu Gln Ser Pro Glu Asp Ala Glu Asp Gly Pro Pro Glu Leu Leu Phe 
        355                 360                 365             


Ile His Gly Gly His Thr Ala Lys Ile Ser Asp Phe Ser Trp Asn Pro 
    370                 375                 380                 


Asn Glu Pro Trp Val Ile Cys Ser Val Ser Glu Asp Asn Ile Met Gln 
385                 390                 395                 400 


Val Trp Gln Met Ala Glu Asn Ile Tyr Asn Asp Glu Asp Pro Glu Gly 
                405                 410                 415     


Ser Val Asp Pro Glu Gly Gln Gly Ser 
            420                 425 


<210>  185
<211>  4167
<212>  DNA
<213>  Homo sapiens

<400>  185
atgagccggc ccccgccgac ggggaaaatg cccggcgccc ccgagaccgc gccgggggac       60

ggggcaggcg cgagccgcca gaggaagctg gaggcgctga tccgagaccc tcgctccccc      120

atcaacgtgg agagcttgct ggatggctta aattccttgg tccttgattt agattttcct      180

gctttgagga aaaacaagaa catagataat ttcttaaata gatatgagaa aattgtgaaa      240

aaaatcagag gtctacagat gaaggcagaa gactatgatg ttgtaaaagt tattggaaga      300

ggtgcttttg gtgaagtgca gttggttcgt cacaaggcat cgcagaaggt ttatgctatg      360

aagcttctta gtaagtttga aatgataaaa agatcagatt ctgccttttt ttgggaagaa      420

agagatatta tggcctttgc caatagcccc tgggtggttc agctttttta tgcctttcaa      480

gatgataggt atctgtacat ggtaatggag tacatgcctg gtggagacct tgtaaacctt      540

atgagtaatt atgatgtgcc tgaaaaatgg gccaaatttt acactgctga agttgttctt      600

gctctggatg caatacactc catgggttta atacacagag atgtgaagcc tgacaacatg      660

ctcttggata aacatggaca tctaaaatta gcagattttg gcacgtgtat gaagatggat      720

gaaacaggca tggtacattg tgatacagca gttggaacac cggattatat atcacctgag      780

gttctgaaat cacaaggggg tgatggtttc tatgggcgag aatgtgattg gtggtctgta      840

ggtgttttcc tttatgagat gctagtgggg gatactccat tttatgcgga ttcacttgta      900

ggaacatata gcaaaattat ggatcataag aattcactgt gtttccctga agatgcagaa      960

atttccaaac atgcaaagaa tctcatctgt gctttcttaa cagataggga ggtacgactt     1020

gggagaaatg gggtggaaga aatcagacag catcctttct ttaagaatga tcagtggcat     1080

tgggataaca taagagaaac ggcagctcct gtagtacctg aactcagcag tgacatagac     1140

agcagcaatt tcgatgacat tgaagatgac aaaggagatg tagaaacctt cccaattcct     1200

aaagcttttg ttggaaatca gctgcctttc atcggattta cctactatag agaaaattta     1260

ttattaagtg actctccatc ttgtagagaa actgattcca tacaatcaag gaaaaatgaa     1320

gaaagtcaag agattcagaa aaaactgtat acattagaag aacatcttag caatgagatg     1380

caagccaaag aggaactgga acagaagtgc aaatctgtta atactcgcct agaaaaaaca     1440

gcaaaggagc tagaagagga gattacctta cggaaaagtg tggaatcagc attaagacag     1500

ttagaaagag aaaaggcgct tcttcagcac aaaaatgcag aatatcagag gaaagctgat     1560

catgaagcag acaaaaaacg aaatttggaa aatgatgtta acagcttaaa agatcaactt     1620

gaagatttga aaaaaagaaa tcaaaactct caaatatcca ctgagaaagt gaatcaactc     1680

cagagacaac tggatgaaac caatgcttta ctgcgaacag agtctgatac tgcagcccgg     1740

ttaaggaaaa cccaggcaga aagttcaaaa cagattcagc agctggaatc taacaataga     1800

gatctacaag ataaaaactg cctgctggag actgccaagt taaaacttga aaaggaattt     1860

atcaatcttc agtcagctct agaatctgaa aggagggatc gaacccatgg atcagagata     1920

attaatgatt tacaaggtag aatatgtggc ctagaagaag atttaaagaa cggcaaaatc     1980

ttactagcga aagtagaact ggagaagaga caacttcagg agagatttac tgatttggaa     2040

aaggaaaaaa gcaacatgga aatagatatg acataccaac taaaagttat acagcagagc     2100

ctagaacaag aagaagctga acataaggcc acaaaggcac gactagcaga taaaaataag     2160

atctatgagt ccatcgaaga agccaaatca gaagccatga aagaaatgga gaagaagctc     2220

ttggaggaaa gaactttaaa acagaaagtg gagaacctat tgctagaagc tgagaaaaga     2280

tgttctctat tagactgtga cctcaaacag tcacagcaga aaataaatga gctccttaaa     2340

cagaaagatg tgctaaatga ggatgttaga aacctgacat taaaaataga gcaagaaact     2400

cagaagcgct gccttacaca aaatgacctg aagatgcaaa cacaacaggt taacacacta     2460

aaaatgtcag aaaagcagtt aaagcaagaa aataaccatc tcatggaaat gaaaatgaac     2520

ttggaaaaac aaaatgctga acttcgaaaa gaacgtcagg atgcagatgg gcaaatgaaa     2580

gagctccagg atcagctcga agcagaacag tatttctcaa ccctttataa aacacaagtt     2640

agggagctta aagaagaatg tgaagaaaag accaaacttg gtaaagaatt gcagcagaag     2700

aaacaggaat tacaggatga acgggactct ttggctgccc aactggagat caccttgacc     2760

aaagcagatt ctgagcaact ggctcgttca attgctgaag aacaatattc tgatttggaa     2820

aaagagaaga tcatgaaaga gctggagatc aaagagatga tggctagaca caaacaggaa     2880

cttacggaaa aagatgctac aattgcttct cttgaggaaa ctaataggac actaactagt     2940

gatgttgcca atcttgcaaa tgagaaagaa gaattaaata acaaattgaa agatgttcaa     3000

gagcaactgt caagattgaa agatgaagaa ataagcgcag cagctattaa agcacagttt     3060

gagaagcagc tattaacaga aagaacactc aaaactcaag ctgtgaataa gttggctgag     3120

atcatgaatc gaaaagaacc tgtcaagcgt ggtaatgaca cagatgtgcg gagaaaagag     3180

aaggagaata gaaagctaca tatggagctt aaatctgaac gtgagaaatt gacccagcag     3240

atgatcaagt atcagaaaga actgaatgaa atgcaggcac aaatagctga agagagccag     3300

attcgaattg aactgcagat gacattggac agtaaagaca gtgacattga gcagctgcgg     3360

tcacaactcc aagccttgca tattggtctg gatagttcca gtataggcag tggaccaggg     3420

gatgctgagg cagatgatgg gtttccagaa tcaagattag aaggatggct ttcattgcct     3480

gtacgaaaca acactaagaa atttggatgg gttaaaaagt atgtgattgt aagcagtaag     3540

aagattcttt tctatgacag tgaacaagat aaagaacaat ccaatcctta catggtttta     3600

gatatagaca agttatttca tgtccgacca gttacacaga cagatgtgta tagagcagat     3660

gctaaagaaa ttccaaggat attccagatt ctgtatgcca atgaaggaga aagtaagaag     3720

gaacaagaat ttccagtgga gccagttgga gaaaaatcta attatatttg ccacaaggga     3780

catgagttta ttcctactct ttatcatttc ccaaccaact gtgaggcttg tatgaagccc     3840

ctgtggcaca tgtttaagcc tcctcctgct ttggagtgcc gccgttgcca tattaagtgt     3900

cataaagatc atatggacaa aaaggaggag attatagcac cttgcaaagt atattatgat     3960

atttcaacgg caaagaatct gttattacta gcaaattcta cagaagagca gcagaagtgg     4020

gttagtcggt tggtgaaaaa gatacctaaa aagcccccag ctccagaccc ttttgcccga     4080

tcatctccta gaacttcaat gaagatacag caaaaccagt ctattagacg gccaagtcga     4140

cagcttgccc caaacaaacc tagctaa                                         4167


<210>  186
<211>  1388
<212>  PRT
<213>  Homo sapiens

<400>  186

Met Ser Arg Pro Pro Pro Thr Gly Lys Met Pro Gly Ala Pro Glu Thr 
1               5                   10                  15      


Ala Pro Gly Asp Gly Ala Gly Ala Ser Arg Gln Arg Lys Leu Glu Ala 
            20                  25                  30          


Leu Ile Arg Asp Pro Arg Ser Pro Ile Asn Val Glu Ser Leu Leu Asp 
        35                  40                  45              


Gly Leu Asn Ser Leu Val Leu Asp Leu Asp Phe Pro Ala Leu Arg Lys 
    50                  55                  60                  


Asn Lys Asn Ile Asp Asn Phe Leu Asn Arg Tyr Glu Lys Ile Val Lys 
65                  70                  75                  80  


Lys Ile Arg Gly Leu Gln Met Lys Ala Glu Asp Tyr Asp Val Val Lys 
                85                  90                  95      


Val Ile Gly Arg Gly Ala Phe Gly Glu Val Gln Leu Val Arg His Lys 
            100                 105                 110         


Ala Ser Gln Lys Val Tyr Ala Met Lys Leu Leu Ser Lys Phe Glu Met 
        115                 120                 125             


Ile Lys Arg Ser Asp Ser Ala Phe Phe Trp Glu Glu Arg Asp Ile Met 
    130                 135                 140                 


Ala Phe Ala Asn Ser Pro Trp Val Val Gln Leu Phe Tyr Ala Phe Gln 
145                 150                 155                 160 


Asp Asp Arg Tyr Leu Tyr Met Val Met Glu Tyr Met Pro Gly Gly Asp 
                165                 170                 175     


Leu Val Asn Leu Met Ser Asn Tyr Asp Val Pro Glu Lys Trp Ala Lys 
            180                 185                 190         


Phe Tyr Thr Ala Glu Val Val Leu Ala Leu Asp Ala Ile His Ser Met 
        195                 200                 205             


Gly Leu Ile His Arg Asp Val Lys Pro Asp Asn Met Leu Leu Asp Lys 
    210                 215                 220                 


His Gly His Leu Lys Leu Ala Asp Phe Gly Thr Cys Met Lys Met Asp 
225                 230                 235                 240 


Glu Thr Gly Met Val His Cys Asp Thr Ala Val Gly Thr Pro Asp Tyr 
                245                 250                 255     


Ile Ser Pro Glu Val Leu Lys Ser Gln Gly Gly Asp Gly Phe Tyr Gly 
            260                 265                 270         


Arg Glu Cys Asp Trp Trp Ser Val Gly Val Phe Leu Tyr Glu Met Leu 
        275                 280                 285             


Val Gly Asp Thr Pro Phe Tyr Ala Asp Ser Leu Val Gly Thr Tyr Ser 
    290                 295                 300                 


Lys Ile Met Asp His Lys Asn Ser Leu Cys Phe Pro Glu Asp Ala Glu 
305                 310                 315                 320 


Ile Ser Lys His Ala Lys Asn Leu Ile Cys Ala Phe Leu Thr Asp Arg 
                325                 330                 335     


Glu Val Arg Leu Gly Arg Asn Gly Val Glu Glu Ile Arg Gln His Pro 
            340                 345                 350         


Phe Phe Lys Asn Asp Gln Trp His Trp Asp Asn Ile Arg Glu Thr Ala 
        355                 360                 365             


Ala Pro Val Val Pro Glu Leu Ser Ser Asp Ile Asp Ser Ser Asn Phe 
    370                 375                 380                 


Asp Asp Ile Glu Asp Asp Lys Gly Asp Val Glu Thr Phe Pro Ile Pro 
385                 390                 395                 400 


Lys Ala Phe Val Gly Asn Gln Leu Pro Phe Ile Gly Phe Thr Tyr Tyr 
                405                 410                 415     


Arg Glu Asn Leu Leu Leu Ser Asp Ser Pro Ser Cys Arg Glu Thr Asp 
            420                 425                 430         


Ser Ile Gln Ser Arg Lys Asn Glu Glu Ser Gln Glu Ile Gln Lys Lys 
        435                 440                 445             


Leu Tyr Thr Leu Glu Glu His Leu Ser Asn Glu Met Gln Ala Lys Glu 
    450                 455                 460                 


Glu Leu Glu Gln Lys Cys Lys Ser Val Asn Thr Arg Leu Glu Lys Thr 
465                 470                 475                 480 


Ala Lys Glu Leu Glu Glu Glu Ile Thr Leu Arg Lys Ser Val Glu Ser 
                485                 490                 495     


Ala Leu Arg Gln Leu Glu Arg Glu Lys Ala Leu Leu Gln His Lys Asn 
            500                 505                 510         


Ala Glu Tyr Gln Arg Lys Ala Asp His Glu Ala Asp Lys Lys Arg Asn 
        515                 520                 525             


Leu Glu Asn Asp Val Asn Ser Leu Lys Asp Gln Leu Glu Asp Leu Lys 
    530                 535                 540                 


Lys Arg Asn Gln Asn Ser Gln Ile Ser Thr Glu Lys Val Asn Gln Leu 
545                 550                 555                 560 


Gln Arg Gln Leu Asp Glu Thr Asn Ala Leu Leu Arg Thr Glu Ser Asp 
                565                 570                 575     


Thr Ala Ala Arg Leu Arg Lys Thr Gln Ala Glu Ser Ser Lys Gln Ile 
            580                 585                 590         


Gln Gln Leu Glu Ser Asn Asn Arg Asp Leu Gln Asp Lys Asn Cys Leu 
        595                 600                 605             


Leu Glu Thr Ala Lys Leu Lys Leu Glu Lys Glu Phe Ile Asn Leu Gln 
    610                 615                 620                 


Ser Ala Leu Glu Ser Glu Arg Arg Asp Arg Thr His Gly Ser Glu Ile 
625                 630                 635                 640 


Ile Asn Asp Leu Gln Gly Arg Ile Cys Gly Leu Glu Glu Asp Leu Lys 
                645                 650                 655     


Asn Gly Lys Ile Leu Leu Ala Lys Val Glu Leu Glu Lys Arg Gln Leu 
            660                 665                 670         


Gln Glu Arg Phe Thr Asp Leu Glu Lys Glu Lys Ser Asn Met Glu Ile 
        675                 680                 685             


Asp Met Thr Tyr Gln Leu Lys Val Ile Gln Gln Ser Leu Glu Gln Glu 
    690                 695                 700                 


Glu Ala Glu His Lys Ala Thr Lys Ala Arg Leu Ala Asp Lys Asn Lys 
705                 710                 715                 720 


Ile Tyr Glu Ser Ile Glu Glu Ala Lys Ser Glu Ala Met Lys Glu Met 
                725                 730                 735     


Glu Lys Lys Leu Leu Glu Glu Arg Thr Leu Lys Gln Lys Val Glu Asn 
            740                 745                 750         


Leu Leu Leu Glu Ala Glu Lys Arg Cys Ser Leu Leu Asp Cys Asp Leu 
        755                 760                 765             


Lys Gln Ser Gln Gln Lys Ile Asn Glu Leu Leu Lys Gln Lys Asp Val 
    770                 775                 780                 


Leu Asn Glu Asp Val Arg Asn Leu Thr Leu Lys Ile Glu Gln Glu Thr 
785                 790                 795                 800 


Gln Lys Arg Cys Leu Thr Gln Asn Asp Leu Lys Met Gln Thr Gln Gln 
                805                 810                 815     


Val Asn Thr Leu Lys Met Ser Glu Lys Gln Leu Lys Gln Glu Asn Asn 
            820                 825                 830         


His Leu Met Glu Met Lys Met Asn Leu Glu Lys Gln Asn Ala Glu Leu 
        835                 840                 845             


Arg Lys Glu Arg Gln Asp Ala Asp Gly Gln Met Lys Glu Leu Gln Asp 
    850                 855                 860                 


Gln Leu Glu Ala Glu Gln Tyr Phe Ser Thr Leu Tyr Lys Thr Gln Val 
865                 870                 875                 880 


Arg Glu Leu Lys Glu Glu Cys Glu Glu Lys Thr Lys Leu Gly Lys Glu 
                885                 890                 895     


Leu Gln Gln Lys Lys Gln Glu Leu Gln Asp Glu Arg Asp Ser Leu Ala 
            900                 905                 910         


Ala Gln Leu Glu Ile Thr Leu Thr Lys Ala Asp Ser Glu Gln Leu Ala 
        915                 920                 925             


Arg Ser Ile Ala Glu Glu Gln Tyr Ser Asp Leu Glu Lys Glu Lys Ile 
    930                 935                 940                 


Met Lys Glu Leu Glu Ile Lys Glu Met Met Ala Arg His Lys Gln Glu 
945                 950                 955                 960 


Leu Thr Glu Lys Asp Ala Thr Ile Ala Ser Leu Glu Glu Thr Asn Arg 
                965                 970                 975     


Thr Leu Thr Ser Asp Val Ala Asn Leu Ala Asn Glu Lys Glu Glu Leu 
            980                 985                 990         


Asn Asn Lys Leu Lys Asp Val Gln  Glu Gln Leu Ser Arg  Leu Lys Asp 
        995                 1000                 1005             


Glu Glu  Ile Ser Ala Ala Ala  Ile Lys Ala Gln Phe  Glu Lys Gln 
    1010                 1015                 1020             


Leu Leu  Thr Glu Arg Thr Leu  Lys Thr Gln Ala Val  Asn Lys Leu 
    1025                 1030                 1035             


Ala Glu  Ile Met Asn Arg Lys  Glu Pro Val Lys Arg  Gly Asn Asp 
    1040                 1045                 1050             


Thr Asp  Val Arg Arg Lys Glu  Lys Glu Asn Arg Lys  Leu His Met 
    1055                 1060                 1065             


Glu Leu  Lys Ser Glu Arg Glu  Lys Leu Thr Gln Gln  Met Ile Lys 
    1070                 1075                 1080             


Tyr Gln  Lys Glu Leu Asn Glu  Met Gln Ala Gln Ile  Ala Glu Glu 
    1085                 1090                 1095             


Ser Gln  Ile Arg Ile Glu Leu  Gln Met Thr Leu Asp  Ser Lys Asp 
    1100                 1105                 1110             


Ser Asp  Ile Glu Gln Leu Arg  Ser Gln Leu Gln Ala  Leu His Ile 
    1115                 1120                 1125             


Gly Leu  Asp Ser Ser Ser Ile  Gly Ser Gly Pro Gly  Asp Ala Glu 
    1130                 1135                 1140             


Ala Asp  Asp Gly Phe Pro Glu  Ser Arg Leu Glu Gly  Trp Leu Ser 
    1145                 1150                 1155             


Leu Pro  Val Arg Asn Asn Thr  Lys Lys Phe Gly Trp  Val Lys Lys 
    1160                 1165                 1170             


Tyr Val  Ile Val Ser Ser Lys  Lys Ile Leu Phe Tyr  Asp Ser Glu 
    1175                 1180                 1185             


Gln Asp  Lys Glu Gln Ser Asn  Pro Tyr Met Val Leu  Asp Ile Asp 
    1190                 1195                 1200             


Lys Leu  Phe His Val Arg Pro  Val Thr Gln Thr Asp  Val Tyr Arg 
    1205                 1210                 1215             


Ala Asp  Ala Lys Glu Ile Pro  Arg Ile Phe Gln Ile  Leu Tyr Ala 
    1220                 1225                 1230             


Asn Glu  Gly Glu Ser Lys Lys  Glu Gln Glu Phe Pro  Val Glu Pro 
    1235                 1240                 1245             


Val Gly  Glu Lys Ser Asn Tyr  Ile Cys His Lys Gly  His Glu Phe 
    1250                 1255                 1260             


Ile Pro  Thr Leu Tyr His Phe  Pro Thr Asn Cys Glu  Ala Cys Met 
    1265                 1270                 1275             


Lys Pro  Leu Trp His Met Phe  Lys Pro Pro Pro Ala  Leu Glu Cys 
    1280                 1285                 1290             


Arg Arg  Cys His Ile Lys Cys  His Lys Asp His Met  Asp Lys Lys 
    1295                 1300                 1305             


Glu Glu  Ile Ile Ala Pro Cys  Lys Val Tyr Tyr Asp  Ile Ser Thr 
    1310                 1315                 1320             


Ala Lys  Asn Leu Leu Leu Leu  Ala Asn Ser Thr Glu  Glu Gln Gln 
    1325                 1330                 1335             


Lys Trp  Val Ser Arg Leu Val  Lys Lys Ile Pro Lys  Lys Pro Pro 
    1340                 1345                 1350             


Ala Pro  Asp Pro Phe Ala Arg  Ser Ser Pro Arg Thr  Ser Met Lys 
    1355                 1360                 1365             


Ile Gln  Gln Asn Gln Ser Ile  Arg Arg Pro Ser Arg  Gln Leu Ala 
    1370                 1375                 1380             


Pro Asn  Lys Pro Ser 
    1385             


<210>  187
<211>  2271
<212>  DNA
<213>  Homo sapiens

<400>  187
atgaatggtg ccccttcccc agaggacggg gcctccccct cgtctccccc gctgccccca       60

cccccgcccc ctagttggcg ggagttctgt gagtcccacg cccgggctgc ggctctggac      120

tttgcccgcc gttttcgcct ctacctggcc tcccaccccc aatatgcggg gcccggggcc      180

gaggctgcct tctcccgccg ttttgctgag ctcttcctgc agcactttga agccgaggtg      240

gcccgggcct ctggctccct gtcgccaccc atcctggctc ccctgagccc tggtgcggag      300

atttcgccac atgacctgtc ccttgagagc tgcagggtgg gtgggcccct ggctgtgctg      360

ggcccttctc gatcatctga ggacctggcc ggccccctcc cttcctcagt ctcttcctcc      420

tctacaacct cctccaagcc gaagctcaag aagcgctttt ccctgcgttc agtgggtcgc      480

tctgtccgag gctcagtccg tggcatcctg cagtggcggg ggaccgttga ccctccctcc      540

tccgctgggc ccctggagac ctcgtcaggc ccccctgtct taggtggaaa cagcaactcc      600

aactcctctg gcggggctgg gaccgttggt aggggactgg tcagtgatgg aacgtcccct      660

ggggaaagat ggactcaccg ttttgagagg ctgagactca gtcggggagg gggcgccttg      720

aaggatggag cagggatggt gcagagggaa gagctgctga gtttcatggg ggctgaggag      780

gcagcccctg acccagccgg agtgggccgg ggaggagggg tggctgggcc tccttcaggg      840

ggaggagggc agcctcagtg gcagaagtgt cgcctgctgc ttcgaagtga aggagaagga      900

ggaggaggaa gtcgcctgga gttctttgta ccacccaagg cctctcggcc ccgactcagc      960

atcccctgct cttctatcac agacgtccgg acaaccacag ccctggagat gcctgaccgg     1020

gagaacacgt ttgtggttaa ggtggaaggt ccatccgagt atatcatgga gacagtggat     1080

gcccagcatg tgaaggcctg ggtgtctgac atccaagaat gcctgagccc aggaccctgc     1140

cctgccacca gtccccgccc catgaccctc cctctggccc ctgggacctc attccttaca     1200

agggagaaca cagacagcct ggagctgtcc tgcctgaatc actcggagag tttacccagc     1260

caggacctgc tgcttggacc cagcgagagc aatgaccgcc tgtcgcaggg ggcatatggg     1320

ggcctctcag accgcccctc ggcatccatc tcccccagct ctgcctccat tgccgcctcc     1380

cattttgact cgatggaact gcttccccca gagttgcccc cccgcatccc cattgaagag     1440

ggacccccag cagggacagt tcatcccctc tcagccccct accctccctt ggacactccg     1500

gaaacagcca cagggtcctt cctgttccag ggggagccag agggcggtga gggggaccag     1560

cccctctcag ggtatccttg gttccacggg atgctctctc ggctcaaggc tgcacagttg     1620

gtgctgactg gcggcactgg ctcccacggt gtcttcctgg tgcgccagag tgagacaagg     1680

cggggtgaat acgtcctcac cttcaacttc cagggcaagg ccaagcacct gcgtttgtcg     1740

ctgaacgagg agggtcagtg ccgggtccag cacctgtggt tccagtccat tttcgatatg     1800

ctcgagcact tccgggtgca ccccatccct ttggagtcgg gaggctccag tgatgttgtc     1860

cttgtcagct atgtcccatc ctcccagcga cagcaggaac cgaccacctc ccatgaccca     1920

ccccagcccc ctgaaccccc ttcatggaca gatcccccac agcctggggc agaagaggcg     1980

tcgagggcgc cagaagtggc ggcagcagca gccgcagcag ccaaagagag gcaagagaaa     2040

gagaaagcgg gcggtggagg ggtcccggaa gagctggtcc ccgtggttga gctggtcccc     2100

gtggttgaat tggaagaggc catagcccca ggctcagagg cccagggcgc tgggtctggt     2160

ggggacgcgg gggtgccccc aatggtgcag ctgcagcagt caccactagg gggtgatgga     2220

gaggaagggg gccaccccag ggccattaac aaccagtact ccttcgtgtg a              2271


<210>  188
<211>  756
<212>  PRT
<213>  Homo sapiens

<400>  188

Met Asn Gly Ala Pro Ser Pro Glu Asp Gly Ala Ser Pro Ser Ser Pro 
1               5                   10                  15      


Pro Leu Pro Pro Pro Pro Pro Pro Ser Trp Arg Glu Phe Cys Glu Ser 
            20                  25                  30          


His Ala Arg Ala Ala Ala Leu Asp Phe Ala Arg Arg Phe Arg Leu Tyr 
        35                  40                  45              


Leu Ala Ser His Pro Gln Tyr Ala Gly Pro Gly Ala Glu Ala Ala Phe 
    50                  55                  60                  


Ser Arg Arg Phe Ala Glu Leu Phe Leu Gln His Phe Glu Ala Glu Val 
65                  70                  75                  80  


Ala Arg Ala Ser Gly Ser Leu Ser Pro Pro Ile Leu Ala Pro Leu Ser 
                85                  90                  95      


Pro Gly Ala Glu Ile Ser Pro His Asp Leu Ser Leu Glu Ser Cys Arg 
            100                 105                 110         


Val Gly Gly Pro Leu Ala Val Leu Gly Pro Ser Arg Ser Ser Glu Asp 
        115                 120                 125             


Leu Ala Gly Pro Leu Pro Ser Ser Val Ser Ser Ser Ser Thr Thr Ser 
    130                 135                 140                 


Ser Lys Pro Lys Leu Lys Lys Arg Phe Ser Leu Arg Ser Val Gly Arg 
145                 150                 155                 160 


Ser Val Arg Gly Ser Val Arg Gly Ile Leu Gln Trp Arg Gly Thr Val 
                165                 170                 175     


Asp Pro Pro Ser Ser Ala Gly Pro Leu Glu Thr Ser Ser Gly Pro Pro 
            180                 185                 190         


Val Leu Gly Gly Asn Ser Asn Ser Asn Ser Ser Gly Gly Ala Gly Thr 
        195                 200                 205             


Val Gly Arg Gly Leu Val Ser Asp Gly Thr Ser Pro Gly Glu Arg Trp 
    210                 215                 220                 


Thr His Arg Phe Glu Arg Leu Arg Leu Ser Arg Gly Gly Gly Ala Leu 
225                 230                 235                 240 


Lys Asp Gly Ala Gly Met Val Gln Arg Glu Glu Leu Leu Ser Phe Met 
                245                 250                 255     


Gly Ala Glu Glu Ala Ala Pro Asp Pro Ala Gly Val Gly Arg Gly Gly 
            260                 265                 270         


Gly Val Ala Gly Pro Pro Ser Gly Gly Gly Gly Gln Pro Gln Trp Gln 
        275                 280                 285             


Lys Cys Arg Leu Leu Leu Arg Ser Glu Gly Glu Gly Gly Gly Gly Ser 
    290                 295                 300                 


Arg Leu Glu Phe Phe Val Pro Pro Lys Ala Ser Arg Pro Arg Leu Ser 
305                 310                 315                 320 


Ile Pro Cys Ser Ser Ile Thr Asp Val Arg Thr Thr Thr Ala Leu Glu 
                325                 330                 335     


Met Pro Asp Arg Glu Asn Thr Phe Val Val Lys Val Glu Gly Pro Ser 
            340                 345                 350         


Glu Tyr Ile Met Glu Thr Val Asp Ala Gln His Val Lys Ala Trp Val 
        355                 360                 365             


Ser Asp Ile Gln Glu Cys Leu Ser Pro Gly Pro Cys Pro Ala Thr Ser 
    370                 375                 380                 


Pro Arg Pro Met Thr Leu Pro Leu Ala Pro Gly Thr Ser Phe Leu Thr 
385                 390                 395                 400 


Arg Glu Asn Thr Asp Ser Leu Glu Leu Ser Cys Leu Asn His Ser Glu 
                405                 410                 415     


Ser Leu Pro Ser Gln Asp Leu Leu Leu Gly Pro Ser Glu Ser Asn Asp 
            420                 425                 430         


Arg Leu Ser Gln Gly Ala Tyr Gly Gly Leu Ser Asp Arg Pro Ser Ala 
        435                 440                 445             


Ser Ile Ser Pro Ser Ser Ala Ser Ile Ala Ala Ser His Phe Asp Ser 
    450                 455                 460                 


Met Glu Leu Leu Pro Pro Glu Leu Pro Pro Arg Ile Pro Ile Glu Glu 
465                 470                 475                 480 


Gly Pro Pro Ala Gly Thr Val His Pro Leu Ser Ala Pro Tyr Pro Pro 
                485                 490                 495     


Leu Asp Thr Pro Glu Thr Ala Thr Gly Ser Phe Leu Phe Gln Gly Glu 
            500                 505                 510         


Pro Glu Gly Gly Glu Gly Asp Gln Pro Leu Ser Gly Tyr Pro Trp Phe 
        515                 520                 525             


His Gly Met Leu Ser Arg Leu Lys Ala Ala Gln Leu Val Leu Thr Gly 
    530                 535                 540                 


Gly Thr Gly Ser His Gly Val Phe Leu Val Arg Gln Ser Glu Thr Arg 
545                 550                 555                 560 


Arg Gly Glu Tyr Val Leu Thr Phe Asn Phe Gln Gly Lys Ala Lys His 
                565                 570                 575     


Leu Arg Leu Ser Leu Asn Glu Glu Gly Gln Cys Arg Val Gln His Leu 
            580                 585                 590         


Trp Phe Gln Ser Ile Phe Asp Met Leu Glu His Phe Arg Val His Pro 
        595                 600                 605             


Ile Pro Leu Glu Ser Gly Gly Ser Ser Asp Val Val Leu Val Ser Tyr 
    610                 615                 620                 


Val Pro Ser Ser Gln Arg Gln Gln Glu Pro Thr Thr Ser His Asp Pro 
625                 630                 635                 640 


Pro Gln Pro Pro Glu Pro Pro Ser Trp Thr Asp Pro Pro Gln Pro Gly 
                645                 650                 655     


Ala Glu Glu Ala Ser Arg Ala Pro Glu Val Ala Ala Ala Ala Ala Ala 
            660                 665                 670         


Ala Ala Lys Glu Arg Gln Glu Lys Glu Lys Ala Gly Gly Gly Gly Val 
        675                 680                 685             


Pro Glu Glu Leu Val Pro Val Val Glu Leu Val Pro Val Val Glu Leu 
    690                 695                 700                 


Glu Glu Ala Ile Ala Pro Gly Ser Glu Ala Gln Gly Ala Gly Ser Gly 
705                 710                 715                 720 


Gly Asp Ala Gly Val Pro Pro Met Val Gln Leu Gln Gln Ser Pro Leu 
                725                 730                 735     


Gly Gly Asp Gly Glu Glu Gly Gly His Pro Arg Ala Ile Asn Asn Gln 
            740                 745                 750         


Tyr Ser Phe Val 
        755     


<210>  189
<211>  1404
<212>  DNA
<213>  Homo sapiens

<400>  189
atgtcgtcca tcttgccatt cacgccgcca gttgtgaaga gactgctggg atggaagaag       60

tcagctggtg ggtctggagg agcaggcgga ggagagcaga atgggcagga agaaaagtgg      120

tgtgagaaag cagtgaaaag tctggtgaag aagctaaaga aaacaggacg attagatgag      180

cttgagaaag ccatcaccac tcaaaactgt aatactaaat gtgttaccat accaagcact      240

tgctctgaaa tttggggact gagtacacca aatacgatag atcagtggga tacaacaggc      300

ctttacagct tctctgaaca aaccaggtct cttgatggtc gtctccaggt atcccatcga      360

aaaggattgc cacatgttat atattgccga ttatggcgct ggcctgatct tcacagtcat      420

catgaactca aggcaattga aaactgcgaa tatgctttta atcttaaaaa ggatgaagta      480

tgtgtaaacc cttaccacta tcagagagtt gagacaccag ttttgcctcc agtattagtg      540

ccccgacaca ccgagatcct aacagaactt ccgcctctgg atgactatac tcactccatt      600

ccagaaaaca ctaacttccc agcaggaatt gagccacaga gtaattatat tccagaaacg      660

ccacctcctg gatatatcag tgaagatgga gaaacaagtg accaacagtt gaatcaaagt      720

atggacacag gctctccagc agaactatct cctactactc tttcccctgt taatcatagc      780

ttggatttac agccagttac ttactcagaa cctgcatttt ggtgttcgat agcatattat      840

gaattaaatc agagggttgg agaaaccttc catgcatcac agccctcact cactgtagat      900

ggctttacag acccatcaaa ttcagagagg ttctgcttag gtttactctc caatgttaac      960

cgaaatgcca cggtagaaat gacaagaagg catataggaa gaggagtgcg cttatactac     1020

ataggtgggg aagtttttgc tgagtgccta agtgatagtg caatctttgt gcagagcccc     1080

aattgtaatc agagatatgg ctggcaccct gcaacagtgt gtaaaattcc accaggctgt     1140

aatctgaaga tcttcaacaa ccaggaattt gctgctcttc tggctcagtc tgttaatcag     1200

ggttttgaag ccgtctatca gctaactaga atgtgcacca taagaatgag ttttgtgaaa     1260

gggtggggag cagaataccg aaggcagacg gtaacaagta ctccttgctg gattgaactt     1320

catctgaatg gacctctaca gtggttggac aaagtattaa ctcagatggg atccccttca     1380

gtgcgttgct caagcatgtc ataa                                            1404


<210>  190
<211>  467
<212>  PRT
<213>  Homo sapiens

<400>  190

Met Ser Ser Ile Leu Pro Phe Thr Pro Pro Val Val Lys Arg Leu Leu 
1               5                   10                  15      


Gly Trp Lys Lys Ser Ala Gly Gly Ser Gly Gly Ala Gly Gly Gly Glu 
            20                  25                  30          


Gln Asn Gly Gln Glu Glu Lys Trp Cys Glu Lys Ala Val Lys Ser Leu 
        35                  40                  45              


Val Lys Lys Leu Lys Lys Thr Gly Arg Leu Asp Glu Leu Glu Lys Ala 
    50                  55                  60                  


Ile Thr Thr Gln Asn Cys Asn Thr Lys Cys Val Thr Ile Pro Ser Thr 
65                  70                  75                  80  


Cys Ser Glu Ile Trp Gly Leu Ser Thr Pro Asn Thr Ile Asp Gln Trp 
                85                  90                  95      


Asp Thr Thr Gly Leu Tyr Ser Phe Ser Glu Gln Thr Arg Ser Leu Asp 
            100                 105                 110         


Gly Arg Leu Gln Val Ser His Arg Lys Gly Leu Pro His Val Ile Tyr 
        115                 120                 125             


Cys Arg Leu Trp Arg Trp Pro Asp Leu His Ser His His Glu Leu Lys 
    130                 135                 140                 


Ala Ile Glu Asn Cys Glu Tyr Ala Phe Asn Leu Lys Lys Asp Glu Val 
145                 150                 155                 160 


Cys Val Asn Pro Tyr His Tyr Gln Arg Val Glu Thr Pro Val Leu Pro 
                165                 170                 175     


Pro Val Leu Val Pro Arg His Thr Glu Ile Leu Thr Glu Leu Pro Pro 
            180                 185                 190         


Leu Asp Asp Tyr Thr His Ser Ile Pro Glu Asn Thr Asn Phe Pro Ala 
        195                 200                 205             


Gly Ile Glu Pro Gln Ser Asn Tyr Ile Pro Glu Thr Pro Pro Pro Gly 
    210                 215                 220                 


Tyr Ile Ser Glu Asp Gly Glu Thr Ser Asp Gln Gln Leu Asn Gln Ser 
225                 230                 235                 240 


Met Asp Thr Gly Ser Pro Ala Glu Leu Ser Pro Thr Thr Leu Ser Pro 
                245                 250                 255     


Val Asn His Ser Leu Asp Leu Gln Pro Val Thr Tyr Ser Glu Pro Ala 
            260                 265                 270         


Phe Trp Cys Ser Ile Ala Tyr Tyr Glu Leu Asn Gln Arg Val Gly Glu 
        275                 280                 285             


Thr Phe His Ala Ser Gln Pro Ser Leu Thr Val Asp Gly Phe Thr Asp 
    290                 295                 300                 


Pro Ser Asn Ser Glu Arg Phe Cys Leu Gly Leu Leu Ser Asn Val Asn 
305                 310                 315                 320 


Arg Asn Ala Thr Val Glu Met Thr Arg Arg His Ile Gly Arg Gly Val 
                325                 330                 335     


Arg Leu Tyr Tyr Ile Gly Gly Glu Val Phe Ala Glu Cys Leu Ser Asp 
            340                 345                 350         


Ser Ala Ile Phe Val Gln Ser Pro Asn Cys Asn Gln Arg Tyr Gly Trp 
        355                 360                 365             


His Pro Ala Thr Val Cys Lys Ile Pro Pro Gly Cys Asn Leu Lys Ile 
    370                 375                 380                 


Phe Asn Asn Gln Glu Phe Ala Ala Leu Leu Ala Gln Ser Val Asn Gln 
385                 390                 395                 400 


Gly Phe Glu Ala Val Tyr Gln Leu Thr Arg Met Cys Thr Ile Arg Met 
                405                 410                 415     


Ser Phe Val Lys Gly Trp Gly Ala Glu Tyr Arg Arg Gln Thr Val Thr 
            420                 425                 430         


Ser Thr Pro Cys Trp Ile Glu Leu His Leu Asn Gly Pro Leu Gln Trp 
        435                 440                 445             


Leu Asp Lys Val Leu Thr Gln Met Gly Ser Pro Ser Val Arg Cys Ser 
    450                 455                 460                 


Ser Met Ser 
465         


<210>  191
<211>  4944
<212>  DNA
<213>  Homo sapiens

<400>  191
atgtccactc cagacccacc cctgggcgga actcctcggc caggtccttc cccgggccct       60

ggcccttccc ctggagccat gctgggccct agcccgggtc cctcgccggg ctccgcccac      120

agcatgatgg ggcccagccc agggccgccc tcagcaggac accccatccc cacccagggg      180

cctggagggt accctcagga caacatgcac cagatgcaca agcccatgga gtccatgcat      240

gagaagggca tgtcggacga cccgcgctac aaccagatga aaggaatggg gatgcggtca      300

gggggccatg ctgggatggg gcccccgccc agccccatgg accagcactc ccaaggttac      360

ccctcgcccc tgggtggctc tgagcatgcc tctagtccag ttccagccag tggcccgtct      420

tcggggcccc agatgtcttc cgggccagga ggtgccccgc tggatggtgc tgacccccag      480

gccttggggc agcagaaccg gggcccaacc ccatttaacc agaaccagct gcaccagctc      540

agagctcaga tcatggccta caagatgctg gccagggggc agcccctccc cgaccacctg      600

cagatggcgg tgcagggcaa gcggccgatg cccgggatgc agcagcagat gccaacgcta      660

cctccaccct cggtgtccgc aacaggaccc ggccctggcc ctggccctgg ccccggcccg      720

ggtcccggcc cggcacctcc aaattacagc aggcctcatg gtatgggagg gcccaacatg      780

cctcccccag gaccctcggg cgtgcccccc gggatgccag gccagcctcc tggagggcct      840

cccaagccct ggcctgaagg acccatggcg aatgctgctg cccccacgag cacccctcag      900

aagctgattc ccccgcagcc aacgggccgc ccttcccccg cgccccctgc cgtcccaccc      960

gccgcctcgc ccgtgatgcc accgcagacc cagtcccccg ggcagccggc ccagcccgcg     1020

cccatggtgc cactgcacca gaagcagagc cgcatcaccc ccatccagaa gccgcggggc     1080

ctcgaccctg tggagatcct gcaggagcgc gagtacaggc tgcaggctcg catcgcacac     1140

cgaattcagg aacttgaaaa ccttcccggg tccctggccg gggatttgcg aaccaaagcg     1200

accattgagc tcaaggccct caggctgctg aacttccaga ggcagctgcg ccaggaggtg     1260

gtggtgtgca tgcggaggga cacagcgctg gagacagccc tcaatgctaa ggcctacaag     1320

cgcagcaagc gccagtccct gcgcgaggcc cgcatcactg agaagctgga gaagcagcag     1380

aagatcgagc aggagcgcaa gcgccggcag aagcaccagg aatacctcaa tagcattctc     1440

cagcatgcca aggatttcaa ggaatatcac agatccgtca caggcaaaat ccagaagctg     1500

accaaggcag tggccacgta ccatgccaac acggagcggg agcagaagaa agagaacgag     1560

cggatcgaga aggagcgcat gcggaggctc atggctgaag atgaggaggg gtaccgcaag     1620

ctcatcgacc agaagaagga caagcgcctg gcctacctct tgcagcagac agacgagtac     1680

gtggctaacc tcacggagct ggtgcggcag cacaaggctg cccaggtcgc caaggagaaa     1740

aagaagaaaa agaaaaagaa gaaggcagaa aatgcagaag gacagacgcc tgccattggg     1800

ccggatggcg agcctctgga cgagaccagc cagatgagcg acctcccggt gaaggtgatc     1860

cacgtggaga gtgggaagat cctcacaggc acagatgccc ccaaagccgg gcagctggag     1920

gcctggctcg agatgaaccc ggggtatgaa gtagctccga ggtctgatag tgaagaaagt     1980

ggctcagaag aagaggaaga ggaggaggag gaagagcagc cgcaggcagc acagcctccc     2040

accctgcccg tggaggagaa gaagaagatt ccagatccag acagcgatga cgtctctgag     2100

gtggacgcgc ggcacatcat tgagaatgcc aagcaagatg tcgatgatga atatggcgtg     2160

tcccaggccc ttgcacgtgg cctgcagtcc tactatgccg tggcccatgc tgtcactgag     2220

agagtggaca agcagtcagc gcttatggtc aatggtgtcc tcaaacagta ccagatcaaa     2280

ggtttggagt ggctggtgtc cctgtacaac aacaacctga acggcatcct ggccgacgag     2340

atgggcctgg ggaagaccat ccagaccatc gcgctcatca cgtacctcat ggagcacaaa     2400

cgcatcaatg ggcccttcct catcatcgtg cctctctcaa cgctgtccaa ctgggcgtac     2460

gagtttgaca agtgggcccc ctccgtggtg aaggtgtctt acaagggatc cccagcagca     2520

agacgggcct ttgtccccca gctccggagt gggaagttca acgtcttgct gacgacgtac     2580

gagtacatca tcaaagacaa gcacatcctc gccaagatcc gttggaagta catgattgtg     2640

gacgaaggtc accgcatgaa gaaccaccac tgcaagctga cgcaggtgct caacacgcac     2700

tatgtggcac cccgccgcct gctgctgacg ggcacaccgc tgcagaacaa gcttcccgag     2760

ctctgggcgc tgctcaactt cctgctgccc accatcttca agagctgcag caccttcgag     2820

cagtggttta acgcaccctt tgccatgacc ggggaaaagg tggacctgaa tgaggaggaa     2880

accattctca tcatccggcg tctccacaaa gtgctgcggc ccttcttgct ccgacgactc     2940

aagaaggaag tcgaggccca gttgcccgaa aaggtggagt acgtcatcaa gtgcgacatg     3000

tctgcgctgc agcgagtgct ctaccgccac atgcaggcca agggcgtgct gctgactgat     3060

ggctccgaga aggacaagaa gggcaaaggc ggcaccaaga ccctgatgaa caccatcatg     3120

cagctgcgga agatctgcaa ccacccctac atgttccagc acatcgagga gtccttttcc     3180

gagcacttgg ggttcactgg cggcattgtc caagggctgg acctgtaccg agcctcgggt     3240

aaatttgagc ttcttgatag aattcttccc aaactccgag caaccaacca caaagtgctg     3300

ctgttctgcc aaatgacctc cctcatgacc atcatggaag attactttgc gtatcgcggc     3360

tttaaatacc tcaggcttga tggaaccacg aaggcggagg accggggcat gctgctgaaa     3420

accttcaacg agcccggctc tgagtacttc atcttcctgc tcagcacccg ggctgggggg     3480

ctcggcctga acctccagtc ggcagacact gtgatcattt ttgacagcga ctggaatcct     3540

caccaggacc tgcaagcgca ggaccgagcc caccgcatcg ggcagcagaa cgaggtgcgt     3600

gtgctccgcc tctgcaccgt caacagcgtg gaggagaaga tcctagctgc agccaagtac     3660

aagctcaacg tggaccagaa ggtgatccag gccggcatgt tcgaccagaa gtcctccagc     3720

catgagcggc gcgccttcct gcaggccatc ctggagcacg aggagcagga tgagagcaga     3780

cactgcagca cgggcagcgg cagtgccagc ttcgcccaca ctgcccctcc gccagcgggc     3840

gtcaaccccg acttggagga gccacctcta aaggaggaag acgaggtgcc cgacgacgag     3900

accgtcaacc agatgatcgc ccggcacgag gaggagtttg atctgttcat gcgcatggac     3960

ctggaccgca ggcgcgagga ggcccgcaac cccaagcgga agccgcgcct catggaggag     4020

gacgagctcc cctcgtggat catcaaggac gacgcggagg tggagcggct gacctgtgag     4080

gaggaggagg agaagatgtt cggccgtggc tcccgccacc gcaaggaggt ggactacagc     4140

gactcactga cggagaagca gtggctcaag gccatcgagg agggcacgct ggaggagatc     4200

gaagaggagg tccggcagaa gaaatcatca cggaagcgca agcgagacag cgacgccggc     4260

tcctccaccc cgaccaccag cacccgcagc cgcgacaagg acgacgagag caagaagcag     4320

aagaagcgcg ggcggccgcc tgccgagaaa ctctccccta acccacccaa cctcaccaag     4380

aagatgaaga agattgtgga tgccgtgatc aagtacaagg acagcagcag tggacgtcag     4440

ctcagcgagg tcttcatcca gctgccctcg cgaaaggagc tgcccgagta ctacgagctc     4500

atccgcaagc ccgtggactt caagaagata aaggagcgca ttcgcaacca caagtaccgc     4560

agcctcaacg acctagagaa ggacgtcatg ctcctgtgcc agaacgcaca gaccttcaac     4620

ctggagggct ccctgatcta tgaagactcc atcgtcttgc agtcggtctt caccagcgtg     4680

cggcagaaaa tcgagaagga ggatgacagt gaaggcgagg agagtgagga ggaggaagag     4740

ggcgaggagg aaggctccga atccgaatct cggtccgtca aagtgaagat caagcttggc     4800

cggaaggaga aggcacagga ccggctgaag ggcggccggc ggcggccgag ccgagggtcc     4860

cgagccaagc cggtcgtgag tgacgatgac agtgaggagg aacaagagga ggaccgctca     4920

ggaagtggca gcgaagaaga ctga                                            4944


<210>  192
<211>  1647
<212>  PRT
<213>  Homo sapiens

<400>  192

Met Ser Thr Pro Asp Pro Pro Leu Gly Gly Thr Pro Arg Pro Gly Pro 
1               5                   10                  15      


Ser Pro Gly Pro Gly Pro Ser Pro Gly Ala Met Leu Gly Pro Ser Pro 
            20                  25                  30          


Gly Pro Ser Pro Gly Ser Ala His Ser Met Met Gly Pro Ser Pro Gly 
        35                  40                  45              


Pro Pro Ser Ala Gly His Pro Ile Pro Thr Gln Gly Pro Gly Gly Tyr 
    50                  55                  60                  


Pro Gln Asp Asn Met His Gln Met His Lys Pro Met Glu Ser Met His 
65                  70                  75                  80  


Glu Lys Gly Met Ser Asp Asp Pro Arg Tyr Asn Gln Met Lys Gly Met 
                85                  90                  95      


Gly Met Arg Ser Gly Gly His Ala Gly Met Gly Pro Pro Pro Ser Pro 
            100                 105                 110         


Met Asp Gln His Ser Gln Gly Tyr Pro Ser Pro Leu Gly Gly Ser Glu 
        115                 120                 125             


His Ala Ser Ser Pro Val Pro Ala Ser Gly Pro Ser Ser Gly Pro Gln 
    130                 135                 140                 


Met Ser Ser Gly Pro Gly Gly Ala Pro Leu Asp Gly Ala Asp Pro Gln 
145                 150                 155                 160 


Ala Leu Gly Gln Gln Asn Arg Gly Pro Thr Pro Phe Asn Gln Asn Gln 
                165                 170                 175     


Leu His Gln Leu Arg Ala Gln Ile Met Ala Tyr Lys Met Leu Ala Arg 
            180                 185                 190         


Gly Gln Pro Leu Pro Asp His Leu Gln Met Ala Val Gln Gly Lys Arg 
        195                 200                 205             


Pro Met Pro Gly Met Gln Gln Gln Met Pro Thr Leu Pro Pro Pro Ser 
    210                 215                 220                 


Val Ser Ala Thr Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro Gly Pro 
225                 230                 235                 240 


Gly Pro Gly Pro Ala Pro Pro Asn Tyr Ser Arg Pro His Gly Met Gly 
                245                 250                 255     


Gly Pro Asn Met Pro Pro Pro Gly Pro Ser Gly Val Pro Pro Gly Met 
            260                 265                 270         


Pro Gly Gln Pro Pro Gly Gly Pro Pro Lys Pro Trp Pro Glu Gly Pro 
        275                 280                 285             


Met Ala Asn Ala Ala Ala Pro Thr Ser Thr Pro Gln Lys Leu Ile Pro 
    290                 295                 300                 


Pro Gln Pro Thr Gly Arg Pro Ser Pro Ala Pro Pro Ala Val Pro Pro 
305                 310                 315                 320 


Ala Ala Ser Pro Val Met Pro Pro Gln Thr Gln Ser Pro Gly Gln Pro 
                325                 330                 335     


Ala Gln Pro Ala Pro Met Val Pro Leu His Gln Lys Gln Ser Arg Ile 
            340                 345                 350         


Thr Pro Ile Gln Lys Pro Arg Gly Leu Asp Pro Val Glu Ile Leu Gln 
        355                 360                 365             


Glu Arg Glu Tyr Arg Leu Gln Ala Arg Ile Ala His Arg Ile Gln Glu 
    370                 375                 380                 


Leu Glu Asn Leu Pro Gly Ser Leu Ala Gly Asp Leu Arg Thr Lys Ala 
385                 390                 395                 400 


Thr Ile Glu Leu Lys Ala Leu Arg Leu Leu Asn Phe Gln Arg Gln Leu 
                405                 410                 415     


Arg Gln Glu Val Val Val Cys Met Arg Arg Asp Thr Ala Leu Glu Thr 
            420                 425                 430         


Ala Leu Asn Ala Lys Ala Tyr Lys Arg Ser Lys Arg Gln Ser Leu Arg 
        435                 440                 445             


Glu Ala Arg Ile Thr Glu Lys Leu Glu Lys Gln Gln Lys Ile Glu Gln 
    450                 455                 460                 


Glu Arg Lys Arg Arg Gln Lys His Gln Glu Tyr Leu Asn Ser Ile Leu 
465                 470                 475                 480 


Gln His Ala Lys Asp Phe Lys Glu Tyr His Arg Ser Val Thr Gly Lys 
                485                 490                 495     


Ile Gln Lys Leu Thr Lys Ala Val Ala Thr Tyr His Ala Asn Thr Glu 
            500                 505                 510         


Arg Glu Gln Lys Lys Glu Asn Glu Arg Ile Glu Lys Glu Arg Met Arg 
        515                 520                 525             


Arg Leu Met Ala Glu Asp Glu Glu Gly Tyr Arg Lys Leu Ile Asp Gln 
    530                 535                 540                 


Lys Lys Asp Lys Arg Leu Ala Tyr Leu Leu Gln Gln Thr Asp Glu Tyr 
545                 550                 555                 560 


Val Ala Asn Leu Thr Glu Leu Val Arg Gln His Lys Ala Ala Gln Val 
                565                 570                 575     


Ala Lys Glu Lys Lys Lys Lys Lys Lys Lys Lys Lys Ala Glu Asn Ala 
            580                 585                 590         


Glu Gly Gln Thr Pro Ala Ile Gly Pro Asp Gly Glu Pro Leu Asp Glu 
        595                 600                 605             


Thr Ser Gln Met Ser Asp Leu Pro Val Lys Val Ile His Val Glu Ser 
    610                 615                 620                 


Gly Lys Ile Leu Thr Gly Thr Asp Ala Pro Lys Ala Gly Gln Leu Glu 
625                 630                 635                 640 


Ala Trp Leu Glu Met Asn Pro Gly Tyr Glu Val Ala Pro Arg Ser Asp 
                645                 650                 655     


Ser Glu Glu Ser Gly Ser Glu Glu Glu Glu Glu Glu Glu Glu Glu Glu 
            660                 665                 670         


Gln Pro Gln Ala Ala Gln Pro Pro Thr Leu Pro Val Glu Glu Lys Lys 
        675                 680                 685             


Lys Ile Pro Asp Pro Asp Ser Asp Asp Val Ser Glu Val Asp Ala Arg 
    690                 695                 700                 


His Ile Ile Glu Asn Ala Lys Gln Asp Val Asp Asp Glu Tyr Gly Val 
705                 710                 715                 720 


Ser Gln Ala Leu Ala Arg Gly Leu Gln Ser Tyr Tyr Ala Val Ala His 
                725                 730                 735     


Ala Val Thr Glu Arg Val Asp Lys Gln Ser Ala Leu Met Val Asn Gly 
            740                 745                 750         


Val Leu Lys Gln Tyr Gln Ile Lys Gly Leu Glu Trp Leu Val Ser Leu 
        755                 760                 765             


Tyr Asn Asn Asn Leu Asn Gly Ile Leu Ala Asp Glu Met Gly Leu Gly 
    770                 775                 780                 


Lys Thr Ile Gln Thr Ile Ala Leu Ile Thr Tyr Leu Met Glu His Lys 
785                 790                 795                 800 


Arg Ile Asn Gly Pro Phe Leu Ile Ile Val Pro Leu Ser Thr Leu Ser 
                805                 810                 815     


Asn Trp Ala Tyr Glu Phe Asp Lys Trp Ala Pro Ser Val Val Lys Val 
            820                 825                 830         


Ser Tyr Lys Gly Ser Pro Ala Ala Arg Arg Ala Phe Val Pro Gln Leu 
        835                 840                 845             


Arg Ser Gly Lys Phe Asn Val Leu Leu Thr Thr Tyr Glu Tyr Ile Ile 
    850                 855                 860                 


Lys Asp Lys His Ile Leu Ala Lys Ile Arg Trp Lys Tyr Met Ile Val 
865                 870                 875                 880 


Asp Glu Gly His Arg Met Lys Asn His His Cys Lys Leu Thr Gln Val 
                885                 890                 895     


Leu Asn Thr His Tyr Val Ala Pro Arg Arg Leu Leu Leu Thr Gly Thr 
            900                 905                 910         


Pro Leu Gln Asn Lys Leu Pro Glu Leu Trp Ala Leu Leu Asn Phe Leu 
        915                 920                 925             


Leu Pro Thr Ile Phe Lys Ser Cys Ser Thr Phe Glu Gln Trp Phe Asn 
    930                 935                 940                 


Ala Pro Phe Ala Met Thr Gly Glu Lys Val Asp Leu Asn Glu Glu Glu 
945                 950                 955                 960 


Thr Ile Leu Ile Ile Arg Arg Leu His Lys Val Leu Arg Pro Phe Leu 
                965                 970                 975     


Leu Arg Arg Leu Lys Lys Glu Val Glu Ala Gln Leu Pro Glu Lys Val 
            980                 985                 990         


Glu Tyr Val Ile Lys Cys Asp Met  Ser Ala Leu Gln Arg  Val Leu Tyr 
        995                 1000                 1005             


Arg His  Met Gln Ala Lys Gly  Val Leu Leu Thr Asp  Gly Ser Glu 
    1010                 1015                 1020             


Lys Asp  Lys Lys Gly Lys Gly  Gly Thr Lys Thr Leu  Met Asn Thr 
    1025                 1030                 1035             


Ile Met  Gln Leu Arg Lys Ile  Cys Asn His Pro Tyr  Met Phe Gln 
    1040                 1045                 1050             


His Ile  Glu Glu Ser Phe Ser  Glu His Leu Gly Phe  Thr Gly Gly 
    1055                 1060                 1065             


Ile Val  Gln Gly Leu Asp Leu  Tyr Arg Ala Ser Gly  Lys Phe Glu 
    1070                 1075                 1080             


Leu Leu  Asp Arg Ile Leu Pro  Lys Leu Arg Ala Thr  Asn His Lys 
    1085                 1090                 1095             


Val Leu  Leu Phe Cys Gln Met  Thr Ser Leu Met Thr  Ile Met Glu 
    1100                 1105                 1110             


Asp Tyr  Phe Ala Tyr Arg Gly  Phe Lys Tyr Leu Arg  Leu Asp Gly 
    1115                 1120                 1125             


Thr Thr  Lys Ala Glu Asp Arg  Gly Met Leu Leu Lys  Thr Phe Asn 
    1130                 1135                 1140             


Glu Pro  Gly Ser Glu Tyr Phe  Ile Phe Leu Leu Ser  Thr Arg Ala 
    1145                 1150                 1155             


Gly Gly  Leu Gly Leu Asn Leu  Gln Ser Ala Asp Thr  Val Ile Ile 
    1160                 1165                 1170             


Phe Asp  Ser Asp Trp Asn Pro  His Gln Asp Leu Gln  Ala Gln Asp 
    1175                 1180                 1185             


Arg Ala  His Arg Ile Gly Gln  Gln Asn Glu Val Arg  Val Leu Arg 
    1190                 1195                 1200             


Leu Cys  Thr Val Asn Ser Val  Glu Glu Lys Ile Leu  Ala Ala Ala 
    1205                 1210                 1215             


Lys Tyr  Lys Leu Asn Val Asp  Gln Lys Val Ile Gln  Ala Gly Met 
    1220                 1225                 1230             


Phe Asp  Gln Lys Ser Ser Ser  His Glu Arg Arg Ala  Phe Leu Gln 
    1235                 1240                 1245             


Ala Ile  Leu Glu His Glu Glu  Gln Asp Glu Ser Arg  His Cys Ser 
    1250                 1255                 1260             


Thr Gly  Ser Gly Ser Ala Ser  Phe Ala His Thr Ala  Pro Pro Pro 
    1265                 1270                 1275             


Ala Gly  Val Asn Pro Asp Leu  Glu Glu Pro Pro Leu  Lys Glu Glu 
    1280                 1285                 1290             


Asp Glu  Val Pro Asp Asp Glu  Thr Val Asn Gln Met  Ile Ala Arg 
    1295                 1300                 1305             


His Glu  Glu Glu Phe Asp Leu  Phe Met Arg Met Asp  Leu Asp Arg 
    1310                 1315                 1320             


Arg Arg  Glu Glu Ala Arg Asn  Pro Lys Arg Lys Pro  Arg Leu Met 
    1325                 1330                 1335             


Glu Glu  Asp Glu Leu Pro Ser  Trp Ile Ile Lys Asp  Asp Ala Glu 
    1340                 1345                 1350             


Val Glu  Arg Leu Thr Cys Glu  Glu Glu Glu Glu Lys  Met Phe Gly 
    1355                 1360                 1365             


Arg Gly  Ser Arg His Arg Lys  Glu Val Asp Tyr Ser  Asp Ser Leu 
    1370                 1375                 1380             


Thr Glu  Lys Gln Trp Leu Lys  Ala Ile Glu Glu Gly  Thr Leu Glu 
    1385                 1390                 1395             


Glu Ile  Glu Glu Glu Val Arg  Gln Lys Lys Ser Ser  Arg Lys Arg 
    1400                 1405                 1410             


Lys Arg  Asp Ser Asp Ala Gly  Ser Ser Thr Pro Thr  Thr Ser Thr 
    1415                 1420                 1425             


Arg Ser  Arg Asp Lys Asp Asp  Glu Ser Lys Lys Gln  Lys Lys Arg 
    1430                 1435                 1440             


Gly Arg  Pro Pro Ala Glu Lys  Leu Ser Pro Asn Pro  Pro Asn Leu 
    1445                 1450                 1455             


Thr Lys  Lys Met Lys Lys Ile  Val Asp Ala Val Ile  Lys Tyr Lys 
    1460                 1465                 1470             


Asp Ser  Ser Ser Gly Arg Gln  Leu Ser Glu Val Phe  Ile Gln Leu 
    1475                 1480                 1485             


Pro Ser  Arg Lys Glu Leu Pro  Glu Tyr Tyr Glu Leu  Ile Arg Lys 
    1490                 1495                 1500             


Pro Val  Asp Phe Lys Lys Ile  Lys Glu Arg Ile Arg  Asn His Lys 
    1505                 1510                 1515             


Tyr Arg  Ser Leu Asn Asp Leu  Glu Lys Asp Val Met  Leu Leu Cys 
    1520                 1525                 1530             


Gln Asn  Ala Gln Thr Phe Asn  Leu Glu Gly Ser Leu  Ile Tyr Glu 
    1535                 1540                 1545             


Asp Ser  Ile Val Leu Gln Ser  Val Phe Thr Ser Val  Arg Gln Lys 
    1550                 1555                 1560             


Ile Glu  Lys Glu Asp Asp Ser  Glu Gly Glu Glu Ser  Glu Glu Glu 
    1565                 1570                 1575             


Glu Glu  Gly Glu Glu Glu Gly  Ser Glu Ser Glu Ser  Arg Ser Val 
    1580                 1585                 1590             


Lys Val  Lys Ile Lys Leu Gly  Arg Lys Glu Lys Ala  Gln Asp Arg 
    1595                 1600                 1605             


Leu Lys  Gly Gly Arg Arg Arg  Pro Ser Arg Gly Ser  Arg Ala Lys 
    1610                 1615                 1620             


Pro Val  Val Ser Asp Asp Asp  Ser Glu Glu Glu Gln  Glu Glu Asp 
    1625                 1630                 1635             


Arg Ser  Gly Ser Gly Ser Glu  Glu Asp 
    1640                 1645         


<210>  193
<211>  3645
<212>  DNA
<213>  Homo sapiens

<400>  193
atggcggtgc ggaagaagga cggcggcccc aacgtgaagt actacgaggc cgcggacacc       60

gtgacccagt tcgacaacgt gcggctgtgg ctcggcaaga actacaagaa gtatatacaa      120

gctgaaccac ccaccaacaa gtccctgtct agcctggttg tacagttgct acaatttcag      180

gaagaagttt ttggcaaaca tgtcagcaat gcaccgctca ctaaactgcc gatcaaatgt      240

ttcctagatt tcaaagcggg aggctccttg tgccacattc ttgcagctgc ctacaaattc      300

aagagtgacc agggatggcg gcgttacgat ttccagaatc catcacgcat ggaccgcaat      360

gtggaaatgt ttatgaccat tgagaagtcc ttggtgcaga ataattgcct gtctcgacct      420

aacatttttc tgtgcccaga aattgagccc aaactactag ggaaattaaa ggacattatc      480

aagagacacc agggaacagt cactgaggat aagaacaatg cctcccatgt tgtgtatcct      540

gtcccgggga atctagaaga agaggaatgg gtacgaccag tcatgaagag ggataagcag      600

gttcttctgc actggggcta ctatcctgac agttacgaca cgtggatccc agcgagtgaa      660

attgaggcat ctgtggaaga tgctccaact cctgagaaac ctaggaaggt tcatgcaaag      720

tggatcctgg acaccgacac cttcaatgaa tggatgaatg aggaagacta tgaagtaaat      780

gatgacaaaa accctgtctc ccgccgaaag aagatttcag ccaagacact gacagatgag      840

gtgaacagcc cagattcaga tcgacgggac aagaaggggg gaaactataa gaagaggaag      900

cgctccccct ctccttcacc aaccccagaa gcaaagaaga aaaatgctaa gaaaggtccc      960

tcaacacctt acactaagtc aaagcgtggc cacagagaag aggagcaaga agacctgaca     1020

aaggacatgg acgagccctc accagtcccc aatgtagaag aggtgacact tcccaaaaca     1080

gtcaacacaa agaaagactc agagtcggcc ccagtcaaag gcggcaccat gaccgacctg     1140

gatgaacagg aagatgaaag catggagacg acgggcaagg atgaggatga gaacagtacg     1200

gggaacaagg gagagcagac caagaatcca gacctgcatg aggacaatgt gactgaacag     1260

acccaccaca tcatcattcc cagctacgct gcctggtttg actacaatag tgttcatgcc     1320

attgagcgga gggctctccc cgagttcttc aacggcaaga acaagtccaa gactccagag     1380

atctacctgg cctatcgaaa ctttatgatt gacacttacc gactgaaccc ccaagagtat     1440

cttacctcta ccgcctgccg ccgaaaccta gcgggtgatg tctgtgccat catgagggtc     1500

catgccttcc tagaacagtg gggtcttatt aactaccagg tggatgctga gagtcgacca     1560

accccaatgg ggcctccgcc tacctctcac ttccatgtct tggctgacac accatcaggg     1620

ctggtgcctc tgcagcccaa gacacctcag cagacctctg cttcccaaca aatgctcaac     1680

tttcctgaca aaggcaaaga gaaaccaaca gacatgcaaa actttgggct gcgcacagac     1740

atgtacacaa aaaagaatgt tccctccaag agcaaggctg cagccagtgc cactcgtgag     1800

tggacagaac aggaaaccct gcttctcctg gaggcactgg aaatgtacaa agatgactgg     1860

aacaaagtgt ccgagcatgt gggaagccgc acacaggacg agtgcatctt gcattttctt     1920

cgtcttccca ttgaagaccc atacctggag gactcagagg cctccctagg ccccctggcc     1980

taccaaccca tccccttcag tcagtcgggc aaccctgtta tgagcactgt tgccttcctg     2040

gcctctgtcg tcgatccccg agtcgcctct gctgctgcaa agtcagccct agaggagttc     2100

tccaaaatga aggaagaggt acccacggcc ttggtggagg cccatgttcg aaaagtggaa     2160

gaagcagcca aagtaacagg caaggcggac cctgccttcg gtctggaaag cagtggcatt     2220

gcaggaacca cctctgatga gcctgagcgg attgaggaga gcgggaatga cgaggctcgg     2280

gtggaaggcc aggccacaga tgagaagaag gagcccaagg aaccccgaga aggagggggt     2340

gctatagagg aggaagcaaa agagaaaacc agcgaggctc ccaagaagga tgaggagaaa     2400

gggaaagaag gcgacagtga gaaggagtcc gagaagagtg atggagaccc aatagtcgat     2460

cctgagaagg agaaggagcc aaaggaaggg caggaggaag tgctgaagga agtggtggag     2520

tctgaggggg aaaggaagac aaaggtggag cgggacattg gcgagggcaa cctctccacc     2580

gctgctgccg ccgccctggc cgccgccgca gtgaaagcta agcacttggc tgctgttgag     2640

gaaaggaaga tcaaatcttt ggtggccctg ctggtggaga cccagatgaa aaagttggag     2700

atcaaacttc ggcactttga ggagctggag actatcatgg accgggagcg agaagcactg     2760

gagtatcaga ggcagcagct cctggccgac agacaagcct tccacatgga gcagctgaag     2820

tatgcggaga tgagggctcg gcagcagcac ttccaacaga tgcaccaaca gcagcagcag     2880

ccaccaccag ccctgccccc aggctcccag cctatccccc caacaggggc tgctgggcca     2940

cccgcagtcc atggcttggc tgtggctcca gcctctgtag tccctgctcc tgctggcagt     3000

ggggcccctc caggaagttt gggcccttct gaacagattg ggcaggcagg gtcaactgca     3060

gggccacagc agcagcaacc agctggagcc ccccagcctg gggcagtccc accaggggtt     3120

cccccccctg gaccccatgg cccctcaccg ttccccaacc aacaaactcc tccctcaatg     3180

atgccagggg cagtgccagg cagcgggcac ccaggcgtgg cgggtaatgc tcctttgggt     3240

ttgccttttg gcatgccgcc tcctcctcct cctcctgctc catccatcat cccatttggt     3300

agtctagctg actccatcag tattaacctc cccgctcctc ctaacctgca tgggcatcac     3360

caccatctcc cgttcgcccc gggcactctc cccccaccta acctgcctgt gtccatggcg     3420

aaccctctac atcctaacct gccggcgacc accaccatgc catcttcctt gcctctcggg     3480

ccggggctcg gatccgccgc agcccaaagc cctgccattg tggcagctgt tcagggcaac     3540

ctcctgccca gtgccagccc actgccagac ccaggcaccc ccctgcctcc agaccccaca     3600

gccccgagcc caggcacggt cacccctgtg ccacctccac agtga                     3645


<210>  194
<211>  1214
<212>  PRT
<213>  Homo sapiens

<400>  194

Met Ala Val Arg Lys Lys Asp Gly Gly Pro Asn Val Lys Tyr Tyr Glu 
1               5                   10                  15      


Ala Ala Asp Thr Val Thr Gln Phe Asp Asn Val Arg Leu Trp Leu Gly 
            20                  25                  30          


Lys Asn Tyr Lys Lys Tyr Ile Gln Ala Glu Pro Pro Thr Asn Lys Ser 
        35                  40                  45              


Leu Ser Ser Leu Val Val Gln Leu Leu Gln Phe Gln Glu Glu Val Phe 
    50                  55                  60                  


Gly Lys His Val Ser Asn Ala Pro Leu Thr Lys Leu Pro Ile Lys Cys 
65                  70                  75                  80  


Phe Leu Asp Phe Lys Ala Gly Gly Ser Leu Cys His Ile Leu Ala Ala 
                85                  90                  95      


Ala Tyr Lys Phe Lys Ser Asp Gln Gly Trp Arg Arg Tyr Asp Phe Gln 
            100                 105                 110         


Asn Pro Ser Arg Met Asp Arg Asn Val Glu Met Phe Met Thr Ile Glu 
        115                 120                 125             


Lys Ser Leu Val Gln Asn Asn Cys Leu Ser Arg Pro Asn Ile Phe Leu 
    130                 135                 140                 


Cys Pro Glu Ile Glu Pro Lys Leu Leu Gly Lys Leu Lys Asp Ile Ile 
145                 150                 155                 160 


Lys Arg His Gln Gly Thr Val Thr Glu Asp Lys Asn Asn Ala Ser His 
                165                 170                 175     


Val Val Tyr Pro Val Pro Gly Asn Leu Glu Glu Glu Glu Trp Val Arg 
            180                 185                 190         


Pro Val Met Lys Arg Asp Lys Gln Val Leu Leu His Trp Gly Tyr Tyr 
        195                 200                 205             


Pro Asp Ser Tyr Asp Thr Trp Ile Pro Ala Ser Glu Ile Glu Ala Ser 
    210                 215                 220                 


Val Glu Asp Ala Pro Thr Pro Glu Lys Pro Arg Lys Val His Ala Lys 
225                 230                 235                 240 


Trp Ile Leu Asp Thr Asp Thr Phe Asn Glu Trp Met Asn Glu Glu Asp 
                245                 250                 255     


Tyr Glu Val Asn Asp Asp Lys Asn Pro Val Ser Arg Arg Lys Lys Ile 
            260                 265                 270         


Ser Ala Lys Thr Leu Thr Asp Glu Val Asn Ser Pro Asp Ser Asp Arg 
        275                 280                 285             


Arg Asp Lys Lys Gly Gly Asn Tyr Lys Lys Arg Lys Arg Ser Pro Ser 
    290                 295                 300                 


Pro Ser Pro Thr Pro Glu Ala Lys Lys Lys Asn Ala Lys Lys Gly Pro 
305                 310                 315                 320 


Ser Thr Pro Tyr Thr Lys Ser Lys Arg Gly His Arg Glu Glu Glu Gln 
                325                 330                 335     


Glu Asp Leu Thr Lys Asp Met Asp Glu Pro Ser Pro Val Pro Asn Val 
            340                 345                 350         


Glu Glu Val Thr Leu Pro Lys Thr Val Asn Thr Lys Lys Asp Ser Glu 
        355                 360                 365             


Ser Ala Pro Val Lys Gly Gly Thr Met Thr Asp Leu Asp Glu Gln Glu 
    370                 375                 380                 


Asp Glu Ser Met Glu Thr Thr Gly Lys Asp Glu Asp Glu Asn Ser Thr 
385                 390                 395                 400 


Gly Asn Lys Gly Glu Gln Thr Lys Asn Pro Asp Leu His Glu Asp Asn 
                405                 410                 415     


Val Thr Glu Gln Thr His His Ile Ile Ile Pro Ser Tyr Ala Ala Trp 
            420                 425                 430         


Phe Asp Tyr Asn Ser Val His Ala Ile Glu Arg Arg Ala Leu Pro Glu 
        435                 440                 445             


Phe Phe Asn Gly Lys Asn Lys Ser Lys Thr Pro Glu Ile Tyr Leu Ala 
    450                 455                 460                 


Tyr Arg Asn Phe Met Ile Asp Thr Tyr Arg Leu Asn Pro Gln Glu Tyr 
465                 470                 475                 480 


Leu Thr Ser Thr Ala Cys Arg Arg Asn Leu Ala Gly Asp Val Cys Ala 
                485                 490                 495     


Ile Met Arg Val His Ala Phe Leu Glu Gln Trp Gly Leu Ile Asn Tyr 
            500                 505                 510         


Gln Val Asp Ala Glu Ser Arg Pro Thr Pro Met Gly Pro Pro Pro Thr 
        515                 520                 525             


Ser His Phe His Val Leu Ala Asp Thr Pro Ser Gly Leu Val Pro Leu 
    530                 535                 540                 


Gln Pro Lys Thr Pro Gln Gln Thr Ser Ala Ser Gln Gln Met Leu Asn 
545                 550                 555                 560 


Phe Pro Asp Lys Gly Lys Glu Lys Pro Thr Asp Met Gln Asn Phe Gly 
                565                 570                 575     


Leu Arg Thr Asp Met Tyr Thr Lys Lys Asn Val Pro Ser Lys Ser Lys 
            580                 585                 590         


Ala Ala Ala Ser Ala Thr Arg Glu Trp Thr Glu Gln Glu Thr Leu Leu 
        595                 600                 605             


Leu Leu Glu Ala Leu Glu Met Tyr Lys Asp Asp Trp Asn Lys Val Ser 
    610                 615                 620                 


Glu His Val Gly Ser Arg Thr Gln Asp Glu Cys Ile Leu His Phe Leu 
625                 630                 635                 640 


Arg Leu Pro Ile Glu Asp Pro Tyr Leu Glu Asp Ser Glu Ala Ser Leu 
                645                 650                 655     


Gly Pro Leu Ala Tyr Gln Pro Ile Pro Phe Ser Gln Ser Gly Asn Pro 
            660                 665                 670         


Val Met Ser Thr Val Ala Phe Leu Ala Ser Val Val Asp Pro Arg Val 
        675                 680                 685             


Ala Ser Ala Ala Ala Lys Ser Ala Leu Glu Glu Phe Ser Lys Met Lys 
    690                 695                 700                 


Glu Glu Val Pro Thr Ala Leu Val Glu Ala His Val Arg Lys Val Glu 
705                 710                 715                 720 


Glu Ala Ala Lys Val Thr Gly Lys Ala Asp Pro Ala Phe Gly Leu Glu 
                725                 730                 735     


Ser Ser Gly Ile Ala Gly Thr Thr Ser Asp Glu Pro Glu Arg Ile Glu 
            740                 745                 750         


Glu Ser Gly Asn Asp Glu Ala Arg Val Glu Gly Gln Ala Thr Asp Glu 
        755                 760                 765             


Lys Lys Glu Pro Lys Glu Pro Arg Glu Gly Gly Gly Ala Ile Glu Glu 
    770                 775                 780                 


Glu Ala Lys Glu Lys Thr Ser Glu Ala Pro Lys Lys Asp Glu Glu Lys 
785                 790                 795                 800 


Gly Lys Glu Gly Asp Ser Glu Lys Glu Ser Glu Lys Ser Asp Gly Asp 
                805                 810                 815     


Pro Ile Val Asp Pro Glu Lys Glu Lys Glu Pro Lys Glu Gly Gln Glu 
            820                 825                 830         


Glu Val Leu Lys Glu Val Val Glu Ser Glu Gly Glu Arg Lys Thr Lys 
        835                 840                 845             


Val Glu Arg Asp Ile Gly Glu Gly Asn Leu Ser Thr Ala Ala Ala Ala 
    850                 855                 860                 


Ala Leu Ala Ala Ala Ala Val Lys Ala Lys His Leu Ala Ala Val Glu 
865                 870                 875                 880 


Glu Arg Lys Ile Lys Ser Leu Val Ala Leu Leu Val Glu Thr Gln Met 
                885                 890                 895     


Lys Lys Leu Glu Ile Lys Leu Arg His Phe Glu Glu Leu Glu Thr Ile 
            900                 905                 910         


Met Asp Arg Glu Arg Glu Ala Leu Glu Tyr Gln Arg Gln Gln Leu Leu 
        915                 920                 925             


Ala Asp Arg Gln Ala Phe His Met Glu Gln Leu Lys Tyr Ala Glu Met 
    930                 935                 940                 


Arg Ala Arg Gln Gln His Phe Gln Gln Met His Gln Gln Gln Gln Gln 
945                 950                 955                 960 


Pro Pro Pro Ala Leu Pro Pro Gly Ser Gln Pro Ile Pro Pro Thr Gly 
                965                 970                 975     


Ala Ala Gly Pro Pro Ala Val His Gly Leu Ala Val Ala Pro Ala Ser 
            980                 985                 990         


Val Val Pro Ala Pro Ala Gly Ser  Gly Ala Pro Pro Gly  Ser Leu Gly 
        995                 1000                 1005             


Pro Ser  Glu Gln Ile Gly Gln  Ala Gly Ser Thr Ala  Gly Pro Gln 
    1010                 1015                 1020             


Gln Gln  Gln Pro Ala Gly Ala  Pro Gln Pro Gly Ala  Val Pro Pro 
    1025                 1030                 1035             


Gly Val  Pro Pro Pro Gly Pro  His Gly Pro Ser Pro  Phe Pro Asn 
    1040                 1045                 1050             


Gln Gln  Thr Pro Pro Ser Met  Met Pro Gly Ala Val  Pro Gly Ser 
    1055                 1060                 1065             


Gly His  Pro Gly Val Ala Gly  Asn Ala Pro Leu Gly  Leu Pro Phe 
    1070                 1075                 1080             


Gly Met  Pro Pro Pro Pro Pro  Pro Pro Ala Pro Ser  Ile Ile Pro 
    1085                 1090                 1095             


Phe Gly  Ser Leu Ala Asp Ser  Ile Ser Ile Asn Leu  Pro Ala Pro 
    1100                 1105                 1110             


Pro Asn  Leu His Gly His His  His His Leu Pro Phe  Ala Pro Gly 
    1115                 1120                 1125             


Thr Leu  Pro Pro Pro Asn Leu  Pro Val Ser Met Ala  Asn Pro Leu 
    1130                 1135                 1140             


His Pro  Asn Leu Pro Ala Thr  Thr Thr Met Pro Ser  Ser Leu Pro 
    1145                 1150                 1155             


Leu Gly  Pro Gly Leu Gly Ser  Ala Ala Ala Gln Ser  Pro Ala Ile 
    1160                 1165                 1170             


Val Ala  Ala Val Gln Gly Asn  Leu Leu Pro Ser Ala  Ser Pro Leu 
    1175                 1180                 1185             


Pro Asp  Pro Gly Thr Pro Leu  Pro Pro Asp Pro Thr  Ala Pro Ser 
    1190                 1195                 1200             


Pro Gly  Thr Val Thr Pro Val  Pro Pro Pro Gln 
    1205                 1210                 


<210>  195
<211>  6645
<212>  DNA
<213>  Homo sapiens

<400>  195
atggcgacac ggagcagcag gagggagtcg cgactcccgt tcctattcac cctggtcgca       60

ctgctgccgc ccggagctct ctgcgaagtc tggacgcaga ggctgcacgg cggcagcgcg      120

cccttgcccc aggaccgggg cttcctcgtg gtgcagggcg acccgcgcga gctgcggctg      180

tgggcgcgcg gggatgccag gggggcgagc cgcgcggacg agaagccgct ccggaggaaa      240

cggagcgctg ccctgcagcc cgagcccatc aaggtgtacg gacaggttag tctgaatgat      300

tcccacaatc agatggtggt gcactgggct ggagagaaaa gcaacgtgat cgtggccttg      360

gcccgagata gcctggcatt ggcgaggccc aagagcagtg atgtgtacgt gtcttacgac      420

tatggaaaat cattcaagaa aatttcagac aagttaaact ttggcttggg aaataggagt      480

gaagctgtta tcgcccagtt ctaccacagc cctgcggaca acaagcggta catctttgca      540

gacgcttatg cccagtacct ctggatcacg tttgacttct gcaacactct tcaaggcttt      600

tccatcccat ttcgggcagc tgatctcctc ctacacagta aggcctccaa ccttctcttg      660

ggctttgaca ggtcccaccc caacaagcag ctgtggaagt cagatgactt tggccagacc      720

tggatcatga ttcaggaaca tgtcaagtcc ttttcttggg gaattgatcc ctatgacaaa      780

ccaaatacca tctacattga acgacatgaa ccctctggct actccactgt cttccgaagt      840

acagatttct tccagtcccg ggaaaaccag gaagtgatcc ttgaggaagt gagagatttt      900

cagcttcggg acaagtacat gtttgctaca aaggtggtgc atctcttggg cagtgaacag      960

cagtcttctg tccagctctg ggtctccttt ggccggaagc ccatgagagc agcccagttt     1020

gtcacaagac atcctattaa tgaatattac atcgcagatg cctccgagga ccaggtgttt     1080

gtgtgtgtca gccacagtaa caaccgcacc aatttataca tctcagaggc agaggggctg     1140

aagttctccc tgtccttgga gaacgtgctc tattacagcc caggaggggc cggcagtgac     1200

accttggtga ggtattttgc aaatgaacca tttgctgact tccaccgagt ggaaggattg     1260

caaggagtct acattgctac tctgattaat ggttctatga atgaggagaa catgagatcg     1320

gtcatcacct ttgacaaagg gggaacctgg gagtttcttc aggctccagc cttcacggga     1380

tatggagaga aaatcaattg tgagctttcc cagggctgtt cccttcatct ggctcagcgc     1440

ctcagtcagc tcctcaacct ccagctccgg agaatgccca tcctgtccaa ggagtcggct     1500

ccaggcctca tcatcgccac tggctcagtg ggaaagaact tggctagcaa gacaaacgtg     1560

tacatctcta gcagtgctgg agccaggtgg cgagaggcac ttcctggacc tcactactac     1620

acatggggag accacggcgg aatcatcacg gctattgccc agggcatgga aaccaacgag     1680

ctaaaataca gtaccaatga aggggagacc tggaaaacat tcatcttctc tgagaagcca     1740

gtgtttgtgt atggcctcct cacagaacct ggggagaaga gcactgtctt caccatcttt     1800

ggctcgaaca aagagaatgt ccacagctgg ctgatcctcc aggtcaatgc cacggatgcc     1860

ttgggagttc cctgcacaga gaatgactac aagctgtggt caccatctga tgagcggggg     1920

aatgagtgtt tgctgggaca caagactgtt ttcaaacggc ggacccccca tgccacatgc     1980

ttcaatggag aggactttga caggccggtg gtcgtgtcca actgctcctg cacccgggag     2040

gactatgagt gtgacttcgg tttcaagatg agtgaagatt tgtcattaga ggtttgtgtt     2100

ccagatccgg aattttctgg aaagtcatac tcccctcctg tgccttgccc tgtgggttct     2160

acttacagga gaacgagagg ctaccggaag atttctgggg acacttgtag cggaggagat     2220

gttgaagcgc gactggaagg agagctggtc ccctgtcccc tggcagaaga gaacgagttc     2280

attctgtatg ctgtgaggaa atccatctac cgctatgacc tggcctcggg agccaccgag     2340

cagttgcctc tcaccgggct acgggcagca gtggccctgg actttgacta tgagcacaac     2400

tgtttgtatt ggtccgacct ggccttggac gtcatccagc gcctctgttt gaatggaagc     2460

acagggcaag aggtgatcat caattctggc ctggagacag tagaagcttt ggcttttgaa     2520

cccctcagcc agctgcttta ctgggtagat gcaggcttca aaaagattga ggtagctaat     2580

ccagatggcg acttccgact cacaatcgtc aattcctctg tgcttgatcg tcccagggct     2640

ctggtcctcg tgccccaaga gggggtgatg ttctggacag actggggaga cctgaagcct     2700

gggatttatc ggagcaatat ggatggttct gctgcctatc acctggtgtc tgaggatgtg     2760

aagtggccca atggcatctc tgtggacgac cagtggattt actggacgga tgcctacctg     2820

gagtgcatag agcggatcac gttcagtggc cagcagcgct ctgtcattct ggacaacctc     2880

ccgcacccct atgccattgc tgtctttaag aatgaaatct actgggatga ctggtcacag     2940

ctcagcatat tccgagcttc caaatacagt gggtcccaga tggagattct ggcaaaccag     3000

ctcacggggc tcatggacat gaagattttc tacaagggga agaacactgg aagcaatgcc     3060

tgtgtgccca ggccatgcag cctgctgtgc ctgcccaagg ccaacaacag tagaagctgc     3120

aggtgtccag aggatgtgtc cagcagtgtg cttccatcag gggacctgat gtgtgactgc     3180

cctcagggct atcagctcaa gaacaatacc tgtgtcaaac aagagaacac ctgtcttcgc     3240

aaccagtatc gctgcagcaa cgggaactgt atcaacagca tttggtggtg tgactttgac     3300

aacgactgtg gagacatgag cgatgagaga aactgcccta ccaccatctg tgacctggac     3360

acccagtttc gttgccagga gtctgggact tgtatcccac tgtcctataa atgtgacctt     3420

gaggatgact gtggagacaa cagtgatgaa agtcattgtg aaatgcacca gtgccggagt     3480

gacgagtaca actgcagttc cggcatgtgc atccgctcct cctgggtatg tgacggggac     3540

aacgactgca gggactggtc tgatgaagcc aactgtaccg ccatctatca cacctgtgag     3600

gcctccaact tccagtgccg aaacgggcac tgcatccccc agcggtgggc gtgtgacggg     3660

gatacggact gccaggatgg ttccgatgag gatccagtca actgtgagaa gaagtgcaat     3720

ggattccgct gcccaaacgg cacttgcatc ccatccagca aacattgtga tggtctgcgt     3780

gattgctctg atggctccga tgaacagcac tgcgagcccc tctgtacgca cttcatggac     3840

tttgtgtgta agaaccgcca gcagtgcctg ttccactcca tggtctgtga cggaatcatc     3900

cagtgccgcg acgggtccga tgaggatgcg gcgtttgcag gatgctccca agatcctgag     3960

ttccacaagg tatgtgatga gttcggtttc cagtgtcaga atggagtgtg catcagtttg     4020

atttggaagt gcgacgggat ggatgattgc ggcgattatt ctgatgaagc caactgcgaa     4080

aaccccacag aagccccaaa ctgctcccgc tacttccagt ttcggtgtga gaatggccac     4140

tgcatcccca acagatggaa atgtgacagg gagaacgact gtggggactg gtctgatgag     4200

aaggattgtg gagattcaca tattcttccc ttctcgactc ctgggccctc cacgtgtctg     4260

cccaattact accgctgcag cagtgggacc tgcgtgatgg acacctgggt gtgcgacggg     4320

taccgagatt gtgcagatgg ctctgacgag gaagcctgcc ccttgcttgc aaacgtcact     4380

gctgcctcca ctcccaccca acttgggcga tgtgaccgat ttgagttcga atgccaccaa     4440

ccgaagacgt gtattcccaa ctggaagcgc tgtgacggcc accaagattg ccaggatggc     4500

cgggacgagg ccaattgccc cacacacagc accttgactt gcatgagcag ggagttccag     4560

tgcgaggacg gggaggcctg cattgtgctc tcggagcgct gcgacggctt cctggactgc     4620

tcggacgaga gcgatgaaaa ggcctgcagt gatgagttga ctgtgtacaa agtacagaat     4680

cttcagtgga cagctgactt ctctggggat gtgactttga cctggatgag gcccaaaaaa     4740

atgccctctg cttcttgtgt atataatgtc tactacaggg tggttggaga gagcatatgg     4800

aagactctgg agacccacag caataagaca aacactgtat taaaagtctt gaaaccagat     4860

accacgtatc aggttaaagt acaggttcag tgtctcagca aggcacacaa caccaatgac     4920

tttgtgaccc tgaggacccc agagggattg ccagatgccc ctcgaaatct ccagctgtca     4980

ctccccaggg aagcagaagg tgtgattgta ggccactggg ctcctcccat ccacacccat     5040

ggcctcatcc gtgagtacat tgtagaatac agcaggagtg gttccaagat gtgggcctcc     5100

cagagggctg ctagtaactt tacagaaatc aagaacttat tggtcaacac tctatacacc     5160

gtcagagtgg ctgcggtgac tagtcgtgga ataggaaact ggagcgattc taaatccatt     5220

accaccataa aaggaaaagt gatcccacca ccagatatcc acattgacag ctatggtgaa     5280

aattatctaa gcttcaccct gaccatggag agtgatatca aggtgaatgg ctatgtggtg     5340

aaccttttct gggcatttga cacccacaag caagagagga gaactttgaa cttccgagga     5400

agcatattgt cacacaaagt tggcaatctg acagctcata catcctatga gatttctgcc     5460

tgggccaaga ctgacttggg ggatagccct ctggcatttg agcatgttat gaccagaggg     5520

gttcgcccac ctgcacctag cctcaaggcc aaagccatca accagactgc agtggaatgt     5580

acctggaccg gcccccggaa tgtggtttat ggtattttct atgccacgtc ctttcttgac     5640

ctctatcgca acccgaagag cttgactact tcactccaca acaagacggt cattgtcagt     5700

aaggatgagc agtatttgtt tctggtccgt gtagtggtac cctaccaggg gccatcctct     5760

gactacgttg tagtgaagat gatcccggac agcaggcttc caccccgtca cctgcatgtg     5820

gttcatacgg gcaaaacctc cgtggtcatc aagtgggaat caccgtatga ctctcctgac     5880

caggacttgt tgtatgcagt tgcagtcaaa gatctcataa gaaagactga caggagctac     5940

aaagtaaaat cccgtaacag cactgtggaa tacaccctta acaagttgga gcctggcggg     6000

aaataccaca tcattgtcca actggggaac atgagcaaag attccagcat aaaaattacc     6060

acagtttcat tatcagcacc tgatgcctta aaaatcataa cagaaaatga tcatgttctt     6120

ctgttttgga aaagcctggc tttaaaggaa aagcatttta atgaaagcag gggctatgag     6180

atacacatgt ttgatagtgc catgaatatc acagcttacc ttgggaatac tactgacaat     6240

ttctttaaaa tttccaacct gaagatgggt cataattaca cgttcaccgt ccaagcaaga     6300

tgcctttttg gcaaccagat ctgtggggag cctgccatcc tgctgtacga tgagctgggg     6360

tctggtgcag atgcatctgc aacgcaggct gccagatcta cggatgttgc tgctgtggtg     6420

gtgcccatct tattcctgat actgctgagc ctgggggtgg ggtttgccat cctgtacacg     6480

aagcaccgga ggctgcagag cagcttcacc gccttcgcca acagccacta cagctccagg     6540

ctggggtccg caatcttctc ctctggggat gacctggggg aagatgatga agatgcccct     6600

atgataactg gattttcaga tgacgtcccc atggtgatag cctga                     6645


<210>  196
<211>  2214
<212>  PRT
<213>  Homo sapiens

<400>  196

Met Ala Thr Arg Ser Ser Arg Arg Glu Ser Arg Leu Pro Phe Leu Phe 
1               5                   10                  15      


Thr Leu Val Ala Leu Leu Pro Pro Gly Ala Leu Cys Glu Val Trp Thr 
            20                  25                  30          


Gln Arg Leu His Gly Gly Ser Ala Pro Leu Pro Gln Asp Arg Gly Phe 
        35                  40                  45              


Leu Val Val Gln Gly Asp Pro Arg Glu Leu Arg Leu Trp Ala Arg Gly 
    50                  55                  60                  


Asp Ala Arg Gly Ala Ser Arg Ala Asp Glu Lys Pro Leu Arg Arg Lys 
65                  70                  75                  80  


Arg Ser Ala Ala Leu Gln Pro Glu Pro Ile Lys Val Tyr Gly Gln Val 
                85                  90                  95      


Ser Leu Asn Asp Ser His Asn Gln Met Val Val His Trp Ala Gly Glu 
            100                 105                 110         


Lys Ser Asn Val Ile Val Ala Leu Ala Arg Asp Ser Leu Ala Leu Ala 
        115                 120                 125             


Arg Pro Lys Ser Ser Asp Val Tyr Val Ser Tyr Asp Tyr Gly Lys Ser 
    130                 135                 140                 


Phe Lys Lys Ile Ser Asp Lys Leu Asn Phe Gly Leu Gly Asn Arg Ser 
145                 150                 155                 160 


Glu Ala Val Ile Ala Gln Phe Tyr His Ser Pro Ala Asp Asn Lys Arg 
                165                 170                 175     


Tyr Ile Phe Ala Asp Ala Tyr Ala Gln Tyr Leu Trp Ile Thr Phe Asp 
            180                 185                 190         


Phe Cys Asn Thr Leu Gln Gly Phe Ser Ile Pro Phe Arg Ala Ala Asp 
        195                 200                 205             


Leu Leu Leu His Ser Lys Ala Ser Asn Leu Leu Leu Gly Phe Asp Arg 
    210                 215                 220                 


Ser His Pro Asn Lys Gln Leu Trp Lys Ser Asp Asp Phe Gly Gln Thr 
225                 230                 235                 240 


Trp Ile Met Ile Gln Glu His Val Lys Ser Phe Ser Trp Gly Ile Asp 
                245                 250                 255     


Pro Tyr Asp Lys Pro Asn Thr Ile Tyr Ile Glu Arg His Glu Pro Ser 
            260                 265                 270         


Gly Tyr Ser Thr Val Phe Arg Ser Thr Asp Phe Phe Gln Ser Arg Glu 
        275                 280                 285             


Asn Gln Glu Val Ile Leu Glu Glu Val Arg Asp Phe Gln Leu Arg Asp 
    290                 295                 300                 


Lys Tyr Met Phe Ala Thr Lys Val Val His Leu Leu Gly Ser Glu Gln 
305                 310                 315                 320 


Gln Ser Ser Val Gln Leu Trp Val Ser Phe Gly Arg Lys Pro Met Arg 
                325                 330                 335     


Ala Ala Gln Phe Val Thr Arg His Pro Ile Asn Glu Tyr Tyr Ile Ala 
            340                 345                 350         


Asp Ala Ser Glu Asp Gln Val Phe Val Cys Val Ser His Ser Asn Asn 
        355                 360                 365             


Arg Thr Asn Leu Tyr Ile Ser Glu Ala Glu Gly Leu Lys Phe Ser Leu 
    370                 375                 380                 


Ser Leu Glu Asn Val Leu Tyr Tyr Ser Pro Gly Gly Ala Gly Ser Asp 
385                 390                 395                 400 


Thr Leu Val Arg Tyr Phe Ala Asn Glu Pro Phe Ala Asp Phe His Arg 
                405                 410                 415     


Val Glu Gly Leu Gln Gly Val Tyr Ile Ala Thr Leu Ile Asn Gly Ser 
            420                 425                 430         


Met Asn Glu Glu Asn Met Arg Ser Val Ile Thr Phe Asp Lys Gly Gly 
        435                 440                 445             


Thr Trp Glu Phe Leu Gln Ala Pro Ala Phe Thr Gly Tyr Gly Glu Lys 
    450                 455                 460                 


Ile Asn Cys Glu Leu Ser Gln Gly Cys Ser Leu His Leu Ala Gln Arg 
465                 470                 475                 480 


Leu Ser Gln Leu Leu Asn Leu Gln Leu Arg Arg Met Pro Ile Leu Ser 
                485                 490                 495     


Lys Glu Ser Ala Pro Gly Leu Ile Ile Ala Thr Gly Ser Val Gly Lys 
            500                 505                 510         


Asn Leu Ala Ser Lys Thr Asn Val Tyr Ile Ser Ser Ser Ala Gly Ala 
        515                 520                 525             


Arg Trp Arg Glu Ala Leu Pro Gly Pro His Tyr Tyr Thr Trp Gly Asp 
    530                 535                 540                 


His Gly Gly Ile Ile Thr Ala Ile Ala Gln Gly Met Glu Thr Asn Glu 
545                 550                 555                 560 


Leu Lys Tyr Ser Thr Asn Glu Gly Glu Thr Trp Lys Thr Phe Ile Phe 
                565                 570                 575     


Ser Glu Lys Pro Val Phe Val Tyr Gly Leu Leu Thr Glu Pro Gly Glu 
            580                 585                 590         


Lys Ser Thr Val Phe Thr Ile Phe Gly Ser Asn Lys Glu Asn Val His 
        595                 600                 605             


Ser Trp Leu Ile Leu Gln Val Asn Ala Thr Asp Ala Leu Gly Val Pro 
    610                 615                 620                 


Cys Thr Glu Asn Asp Tyr Lys Leu Trp Ser Pro Ser Asp Glu Arg Gly 
625                 630                 635                 640 


Asn Glu Cys Leu Leu Gly His Lys Thr Val Phe Lys Arg Arg Thr Pro 
                645                 650                 655     


His Ala Thr Cys Phe Asn Gly Glu Asp Phe Asp Arg Pro Val Val Val 
            660                 665                 670         


Ser Asn Cys Ser Cys Thr Arg Glu Asp Tyr Glu Cys Asp Phe Gly Phe 
        675                 680                 685             


Lys Met Ser Glu Asp Leu Ser Leu Glu Val Cys Val Pro Asp Pro Glu 
    690                 695                 700                 


Phe Ser Gly Lys Ser Tyr Ser Pro Pro Val Pro Cys Pro Val Gly Ser 
705                 710                 715                 720 


Thr Tyr Arg Arg Thr Arg Gly Tyr Arg Lys Ile Ser Gly Asp Thr Cys 
                725                 730                 735     


Ser Gly Gly Asp Val Glu Ala Arg Leu Glu Gly Glu Leu Val Pro Cys 
            740                 745                 750         


Pro Leu Ala Glu Glu Asn Glu Phe Ile Leu Tyr Ala Val Arg Lys Ser 
        755                 760                 765             


Ile Tyr Arg Tyr Asp Leu Ala Ser Gly Ala Thr Glu Gln Leu Pro Leu 
    770                 775                 780                 


Thr Gly Leu Arg Ala Ala Val Ala Leu Asp Phe Asp Tyr Glu His Asn 
785                 790                 795                 800 


Cys Leu Tyr Trp Ser Asp Leu Ala Leu Asp Val Ile Gln Arg Leu Cys 
                805                 810                 815     


Leu Asn Gly Ser Thr Gly Gln Glu Val Ile Ile Asn Ser Gly Leu Glu 
            820                 825                 830         


Thr Val Glu Ala Leu Ala Phe Glu Pro Leu Ser Gln Leu Leu Tyr Trp 
        835                 840                 845             


Val Asp Ala Gly Phe Lys Lys Ile Glu Val Ala Asn Pro Asp Gly Asp 
    850                 855                 860                 


Phe Arg Leu Thr Ile Val Asn Ser Ser Val Leu Asp Arg Pro Arg Ala 
865                 870                 875                 880 


Leu Val Leu Val Pro Gln Glu Gly Val Met Phe Trp Thr Asp Trp Gly 
                885                 890                 895     


Asp Leu Lys Pro Gly Ile Tyr Arg Ser Asn Met Asp Gly Ser Ala Ala 
            900                 905                 910         


Tyr His Leu Val Ser Glu Asp Val Lys Trp Pro Asn Gly Ile Ser Val 
        915                 920                 925             


Asp Asp Gln Trp Ile Tyr Trp Thr Asp Ala Tyr Leu Glu Cys Ile Glu 
    930                 935                 940                 


Arg Ile Thr Phe Ser Gly Gln Gln Arg Ser Val Ile Leu Asp Asn Leu 
945                 950                 955                 960 


Pro His Pro Tyr Ala Ile Ala Val Phe Lys Asn Glu Ile Tyr Trp Asp 
                965                 970                 975     


Asp Trp Ser Gln Leu Ser Ile Phe Arg Ala Ser Lys Tyr Ser Gly Ser 
            980                 985                 990         


Gln Met Glu Ile Leu Ala Asn Gln  Leu Thr Gly Leu Met  Asp Met Lys 
        995                 1000                 1005             


Ile Phe  Tyr Lys Gly Lys Asn  Thr Gly Ser Asn Ala  Cys Val Pro 
    1010                 1015                 1020             


Arg Pro  Cys Ser Leu Leu Cys  Leu Pro Lys Ala Asn  Asn Ser Arg 
    1025                 1030                 1035             


Ser Cys  Arg Cys Pro Glu Asp  Val Ser Ser Ser Val  Leu Pro Ser 
    1040                 1045                 1050             


Gly Asp  Leu Met Cys Asp Cys  Pro Gln Gly Tyr Gln  Leu Lys Asn 
    1055                 1060                 1065             


Asn Thr  Cys Val Lys Gln Glu  Asn Thr Cys Leu Arg  Asn Gln Tyr 
    1070                 1075                 1080             


Arg Cys  Ser Asn Gly Asn Cys  Ile Asn Ser Ile Trp  Trp Cys Asp 
    1085                 1090                 1095             


Phe Asp  Asn Asp Cys Gly Asp  Met Ser Asp Glu Arg  Asn Cys Pro 
    1100                 1105                 1110             


Thr Thr  Ile Cys Asp Leu Asp  Thr Gln Phe Arg Cys  Gln Glu Ser 
    1115                 1120                 1125             


Gly Thr  Cys Ile Pro Leu Ser  Tyr Lys Cys Asp Leu  Glu Asp Asp 
    1130                 1135                 1140             


Cys Gly  Asp Asn Ser Asp Glu  Ser His Cys Glu Met  His Gln Cys 
    1145                 1150                 1155             


Arg Ser  Asp Glu Tyr Asn Cys  Ser Ser Gly Met Cys  Ile Arg Ser 
    1160                 1165                 1170             


Ser Trp  Val Cys Asp Gly Asp  Asn Asp Cys Arg Asp  Trp Ser Asp 
    1175                 1180                 1185             


Glu Ala  Asn Cys Thr Ala Ile  Tyr His Thr Cys Glu  Ala Ser Asn 
    1190                 1195                 1200             


Phe Gln  Cys Arg Asn Gly His  Cys Ile Pro Gln Arg  Trp Ala Cys 
    1205                 1210                 1215             


Asp Gly  Asp Thr Asp Cys Gln  Asp Gly Ser Asp Glu  Asp Pro Val 
    1220                 1225                 1230             


Asn Cys  Glu Lys Lys Cys Asn  Gly Phe Arg Cys Pro  Asn Gly Thr 
    1235                 1240                 1245             


Cys Ile  Pro Ser Ser Lys His  Cys Asp Gly Leu Arg  Asp Cys Ser 
    1250                 1255                 1260             


Asp Gly  Ser Asp Glu Gln His  Cys Glu Pro Leu Cys  Thr His Phe 
    1265                 1270                 1275             


Met Asp  Phe Val Cys Lys Asn  Arg Gln Gln Cys Leu  Phe His Ser 
    1280                 1285                 1290             


Met Val  Cys Asp Gly Ile Ile  Gln Cys Arg Asp Gly  Ser Asp Glu 
    1295                 1300                 1305             


Asp Ala  Ala Phe Ala Gly Cys  Ser Gln Asp Pro Glu  Phe His Lys 
    1310                 1315                 1320             


Val Cys  Asp Glu Phe Gly Phe  Gln Cys Gln Asn Gly  Val Cys Ile 
    1325                 1330                 1335             


Ser Leu  Ile Trp Lys Cys Asp  Gly Met Asp Asp Cys  Gly Asp Tyr 
    1340                 1345                 1350             


Ser Asp  Glu Ala Asn Cys Glu  Asn Pro Thr Glu Ala  Pro Asn Cys 
    1355                 1360                 1365             


Ser Arg  Tyr Phe Gln Phe Arg  Cys Glu Asn Gly His  Cys Ile Pro 
    1370                 1375                 1380             


Asn Arg  Trp Lys Cys Asp Arg  Glu Asn Asp Cys Gly  Asp Trp Ser 
    1385                 1390                 1395             


Asp Glu  Lys Asp Cys Gly Asp  Ser His Ile Leu Pro  Phe Ser Thr 
    1400                 1405                 1410             


Pro Gly  Pro Ser Thr Cys Leu  Pro Asn Tyr Tyr Arg  Cys Ser Ser 
    1415                 1420                 1425             


Gly Thr  Cys Val Met Asp Thr  Trp Val Cys Asp Gly  Tyr Arg Asp 
    1430                 1435                 1440             


Cys Ala  Asp Gly Ser Asp Glu  Glu Ala Cys Pro Leu  Leu Ala Asn 
    1445                 1450                 1455             


Val Thr  Ala Ala Ser Thr Pro  Thr Gln Leu Gly Arg  Cys Asp Arg 
    1460                 1465                 1470             


Phe Glu  Phe Glu Cys His Gln  Pro Lys Thr Cys Ile  Pro Asn Trp 
    1475                 1480                 1485             


Lys Arg  Cys Asp Gly His Gln  Asp Cys Gln Asp Gly  Arg Asp Glu 
    1490                 1495                 1500             


Ala Asn  Cys Pro Thr His Ser  Thr Leu Thr Cys Met  Ser Arg Glu 
    1505                 1510                 1515             


Phe Gln  Cys Glu Asp Gly Glu  Ala Cys Ile Val Leu  Ser Glu Arg 
    1520                 1525                 1530             


Cys Asp  Gly Phe Leu Asp Cys  Ser Asp Glu Ser Asp  Glu Lys Ala 
    1535                 1540                 1545             


Cys Ser  Asp Glu Leu Thr Val  Tyr Lys Val Gln Asn  Leu Gln Trp 
    1550                 1555                 1560             


Thr Ala  Asp Phe Ser Gly Asp  Val Thr Leu Thr Trp  Met Arg Pro 
    1565                 1570                 1575             


Lys Lys  Met Pro Ser Ala Ser  Cys Val Tyr Asn Val  Tyr Tyr Arg 
    1580                 1585                 1590             


Val Val  Gly Glu Ser Ile Trp  Lys Thr Leu Glu Thr  His Ser Asn 
    1595                 1600                 1605             


Lys Thr  Asn Thr Val Leu Lys  Val Leu Lys Pro Asp  Thr Thr Tyr 
    1610                 1615                 1620             


Gln Val  Lys Val Gln Val Gln  Cys Leu Ser Lys Ala  His Asn Thr 
    1625                 1630                 1635             


Asn Asp  Phe Val Thr Leu Arg  Thr Pro Glu Gly Leu  Pro Asp Ala 
    1640                 1645                 1650             


Pro Arg  Asn Leu Gln Leu Ser  Leu Pro Arg Glu Ala  Glu Gly Val 
    1655                 1660                 1665             


Ile Val  Gly His Trp Ala Pro  Pro Ile His Thr His  Gly Leu Ile 
    1670                 1675                 1680             


Arg Glu  Tyr Ile Val Glu Tyr  Ser Arg Ser Gly Ser  Lys Met Trp 
    1685                 1690                 1695             


Ala Ser  Gln Arg Ala Ala Ser  Asn Phe Thr Glu Ile  Lys Asn Leu 
    1700                 1705                 1710             


Leu Val  Asn Thr Leu Tyr Thr  Val Arg Val Ala Ala  Val Thr Ser 
    1715                 1720                 1725             


Arg Gly  Ile Gly Asn Trp Ser  Asp Ser Lys Ser Ile  Thr Thr Ile 
    1730                 1735                 1740             


Lys Gly  Lys Val Ile Pro Pro  Pro Asp Ile His Ile  Asp Ser Tyr 
    1745                 1750                 1755             


Gly Glu  Asn Tyr Leu Ser Phe  Thr Leu Thr Met Glu  Ser Asp Ile 
    1760                 1765                 1770             


Lys Val  Asn Gly Tyr Val Val  Asn Leu Phe Trp Ala  Phe Asp Thr 
    1775                 1780                 1785             


His Lys  Gln Glu Arg Arg Thr  Leu Asn Phe Arg Gly  Ser Ile Leu 
    1790                 1795                 1800             


Ser His  Lys Val Gly Asn Leu  Thr Ala His Thr Ser  Tyr Glu Ile 
    1805                 1810                 1815             


Ser Ala  Trp Ala Lys Thr Asp  Leu Gly Asp Ser Pro  Leu Ala Phe 
    1820                 1825                 1830             


Glu His  Val Met Thr Arg Gly  Val Arg Pro Pro Ala  Pro Ser Leu 
    1835                 1840                 1845             


Lys Ala  Lys Ala Ile Asn Gln  Thr Ala Val Glu Cys  Thr Trp Thr 
    1850                 1855                 1860             


Gly Pro  Arg Asn Val Val Tyr  Gly Ile Phe Tyr Ala  Thr Ser Phe 
    1865                 1870                 1875             


Leu Asp  Leu Tyr Arg Asn Pro  Lys Ser Leu Thr Thr  Ser Leu His 
    1880                 1885                 1890             


Asn Lys  Thr Val Ile Val Ser  Lys Asp Glu Gln Tyr  Leu Phe Leu 
    1895                 1900                 1905             


Val Arg  Val Val Val Pro Tyr  Gln Gly Pro Ser Ser  Asp Tyr Val 
    1910                 1915                 1920             


Val Val  Lys Met Ile Pro Asp  Ser Arg Leu Pro Pro  Arg His Leu 
    1925                 1930                 1935             


His Val  Val His Thr Gly Lys  Thr Ser Val Val Ile  Lys Trp Glu 
    1940                 1945                 1950             


Ser Pro  Tyr Asp Ser Pro Asp  Gln Asp Leu Leu Tyr  Ala Val Ala 
    1955                 1960                 1965             


Val Lys  Asp Leu Ile Arg Lys  Thr Asp Arg Ser Tyr  Lys Val Lys 
    1970                 1975                 1980             


Ser Arg  Asn Ser Thr Val Glu  Tyr Thr Leu Asn Lys  Leu Glu Pro 
    1985                 1990                 1995             


Gly Gly  Lys Tyr His Ile Ile  Val Gln Leu Gly Asn  Met Ser Lys 
    2000                 2005                 2010             


Asp Ser  Ser Ile Lys Ile Thr  Thr Val Ser Leu Ser  Ala Pro Asp 
    2015                 2020                 2025             


Ala Leu  Lys Ile Ile Thr Glu  Asn Asp His Val Leu  Leu Phe Trp 
    2030                 2035                 2040             


Lys Ser  Leu Ala Leu Lys Glu  Lys His Phe Asn Glu  Ser Arg Gly 
    2045                 2050                 2055             


Tyr Glu  Ile His Met Phe Asp  Ser Ala Met Asn Ile  Thr Ala Tyr 
    2060                 2065                 2070             


Leu Gly  Asn Thr Thr Asp Asn  Phe Phe Lys Ile Ser  Asn Leu Lys 
    2075                 2080                 2085             


Met Gly  His Asn Tyr Thr Phe  Thr Val Gln Ala Arg  Cys Leu Phe 
    2090                 2095                 2100             


Gly Asn  Gln Ile Cys Gly Glu  Pro Ala Ile Leu Leu  Tyr Asp Glu 
    2105                 2110                 2115             


Leu Gly  Ser Gly Ala Asp Ala  Ser Ala Thr Gln Ala  Ala Arg Ser 
    2120                 2125                 2130             


Thr Asp  Val Ala Ala Val Val  Val Pro Ile Leu Phe  Leu Ile Leu 
    2135                 2140                 2145             


Leu Ser  Leu Gly Val Gly Phe  Ala Ile Leu Tyr Thr  Lys His Arg 
    2150                 2155                 2160             


Arg Leu  Gln Ser Ser Phe Thr  Ala Phe Ala Asn Ser  His Tyr Ser 
    2165                 2170                 2175             


Ser Arg  Leu Gly Ser Ala Ile  Phe Ser Ser Gly Asp  Asp Leu Gly 
    2180                 2185                 2190             


Glu Asp  Asp Glu Asp Ala Pro  Met Ile Thr Gly Phe  Ser Asp Asp 
    2195                 2200                 2205             


Val Pro  Met Val Ile Ala 
    2210                 


<210>  197
<211>  1212
<212>  DNA
<213>  Homo sapiens

<400>  197
atggaccgat ctaaagaaaa ctgcatttca ggacctgtta aggctacagc tccagttgga       60

ggtccaaaac gtgttctcgt gactcagcaa tttccttgtc agaatccatt acctgtaaat      120

agtggccagg ctcagcgggt cttgtgtcct tcaaattctt cccagcgcat tcctttgcaa      180

gcacaaaagc ttgtctccag tcacaagccg gttcagaatc agaagcagaa gcaattgcag      240

gcaaccagtg tacctcatcc tgtctccagg ccactgaata acacccaaaa gagcaagcag      300

cccctgccat cggcacctga aaataatcct gaggaggaac tggcatcaaa acagaaaaat      360

gaagaatcaa aaaagaggca gtgggctttg gaagactttg aaattggtcg ccctctgggt      420

aaaggaaagt ttggtaatgt ttatttggca agagaaaagc aaagcaagtt tattctggct      480

cttaaagtgt tatttaaagc tcagctggag aaagccggag tggagcatca gctcagaaga      540

gaagtagaaa tacagtccca ccttcggcat cctaatattc ttagactgta tggttatttc      600

catgatgcta ccagagtcta cctaattctg gaatatgcac cacttggaac agtttataga      660

gaacttcaga aactttcaaa gtttgatgag cagagaactg ctacttatat aacagaattg      720

gcaaatgccc tgtcttactg tcattcgaag agagttattc atagagacat taagccagag      780

aacttacttc ttggatcagc tggagagctt aaaattgcag attttgggtg gtcagtacat      840

gctccatctt ccaggaggac cactctctgt ggcaccctgg actacctgcc ccctgaaatg      900

attgaaggtc ggatgcatga tgagaaggtg gatctctgga gccttggagt tctttgctat      960

gaatttttag ttgggaagcc tccttttgag gcaaacacat accaagagac ctacaaaaga     1020

atatcacggg ttgaattcac attccctgac tttgtaacag agggagccag ggacctcatt     1080

tcaagactgt tgaagcataa tcccagccag aggccaatgc tcagagaagt acttgaacac     1140

ccctggatca cagcaaattc atcaaaacca tcaaattgcc aaaacaaaga atcagctagc     1200

aaacagtctt ag                                                         1212


<210>  198
<211>  403
<212>  PRT
<213>  Homo sapiens

<400>  198

Met Asp Arg Ser Lys Glu Asn Cys Ile Ser Gly Pro Val Lys Ala Thr 
1               5                   10                  15      


Ala Pro Val Gly Gly Pro Lys Arg Val Leu Val Thr Gln Gln Phe Pro 
            20                  25                  30          


Cys Gln Asn Pro Leu Pro Val Asn Ser Gly Gln Ala Gln Arg Val Leu 
        35                  40                  45              


Cys Pro Ser Asn Ser Ser Gln Arg Ile Pro Leu Gln Ala Gln Lys Leu 
    50                  55                  60                  


Val Ser Ser His Lys Pro Val Gln Asn Gln Lys Gln Lys Gln Leu Gln 
65                  70                  75                  80  


Ala Thr Ser Val Pro His Pro Val Ser Arg Pro Leu Asn Asn Thr Gln 
                85                  90                  95      


Lys Ser Lys Gln Pro Leu Pro Ser Ala Pro Glu Asn Asn Pro Glu Glu 
            100                 105                 110         


Glu Leu Ala Ser Lys Gln Lys Asn Glu Glu Ser Lys Lys Arg Gln Trp 
        115                 120                 125             


Ala Leu Glu Asp Phe Glu Ile Gly Arg Pro Leu Gly Lys Gly Lys Phe 
    130                 135                 140                 


Gly Asn Val Tyr Leu Ala Arg Glu Lys Gln Ser Lys Phe Ile Leu Ala 
145                 150                 155                 160 


Leu Lys Val Leu Phe Lys Ala Gln Leu Glu Lys Ala Gly Val Glu His 
                165                 170                 175     


Gln Leu Arg Arg Glu Val Glu Ile Gln Ser His Leu Arg His Pro Asn 
            180                 185                 190         


Ile Leu Arg Leu Tyr Gly Tyr Phe His Asp Ala Thr Arg Val Tyr Leu 
        195                 200                 205             


Ile Leu Glu Tyr Ala Pro Leu Gly Thr Val Tyr Arg Glu Leu Gln Lys 
    210                 215                 220                 


Leu Ser Lys Phe Asp Glu Gln Arg Thr Ala Thr Tyr Ile Thr Glu Leu 
225                 230                 235                 240 


Ala Asn Ala Leu Ser Tyr Cys His Ser Lys Arg Val Ile His Arg Asp 
                245                 250                 255     


Ile Lys Pro Glu Asn Leu Leu Leu Gly Ser Ala Gly Glu Leu Lys Ile 
            260                 265                 270         


Ala Asp Phe Gly Trp Ser Val His Ala Pro Ser Ser Arg Arg Thr Thr 
        275                 280                 285             


Leu Cys Gly Thr Leu Asp Tyr Leu Pro Pro Glu Met Ile Glu Gly Arg 
    290                 295                 300                 


Met His Asp Glu Lys Val Asp Leu Trp Ser Leu Gly Val Leu Cys Tyr 
305                 310                 315                 320 


Glu Phe Leu Val Gly Lys Pro Pro Phe Glu Ala Asn Thr Tyr Gln Glu 
                325                 330                 335     


Thr Tyr Lys Arg Ile Ser Arg Val Glu Phe Thr Phe Pro Asp Phe Val 
            340                 345                 350         


Thr Glu Gly Ala Arg Asp Leu Ile Ser Arg Leu Leu Lys His Asn Pro 
        355                 360                 365             


Ser Gln Arg Pro Met Leu Arg Glu Val Leu Glu His Pro Trp Ile Thr 
    370                 375                 380                 


Ala Asn Ser Ser Lys Pro Ser Asn Cys Gln Asn Lys Glu Ser Ala Ser 
385                 390                 395                 400 


Lys Gln Ser 
            


<210>  199
<211>  450
<212>  DNA
<213>  Homo sapiens

<400>  199
atggcttctt ctgatatcca ggtgaaagaa ctggagaagc gtgcctcagg ccaggctttt       60

gagctgattc tcagccctcg gtcaaaagaa tctgttccag aattccccct ttcccctcca      120

aagaagaagg atctttccct ggaggaaatt cagaagaaat tagaagctgc agaagaaaga      180

cgcaagtccc atgaagctga ggtcttgaag cagctggctg agaaacgaga gcacgagaaa      240

gaagtgcttc agaaggcaat agaagagaac aacaacttca gtaaaatggc agaagagaaa      300

ctgacccaca aaatggaagc taataaagag aaccgagagg cacaaatggc tgccaaactg      360

gaacgtttgc gagagaagga taagcacatt gaagaagtgc ggaagaacaa agaatccaaa      420

gaccctgctg acgagactga agctgactaa                                       450


<210>  200
<211>  149
<212>  PRT
<213>  Homo sapiens

<400>  200

Met Ala Ser Ser Asp Ile Gln Val Lys Glu Leu Glu Lys Arg Ala Ser 
1               5                   10                  15      


Gly Gln Ala Phe Glu Leu Ile Leu Ser Pro Arg Ser Lys Glu Ser Val 
            20                  25                  30          


Pro Glu Phe Pro Leu Ser Pro Pro Lys Lys Lys Asp Leu Ser Leu Glu 
        35                  40                  45              


Glu Ile Gln Lys Lys Leu Glu Ala Ala Glu Glu Arg Arg Lys Ser His 
    50                  55                  60                  


Glu Ala Glu Val Leu Lys Gln Leu Ala Glu Lys Arg Glu His Glu Lys 
65                  70                  75                  80  


Glu Val Leu Gln Lys Ala Ile Glu Glu Asn Asn Asn Phe Ser Lys Met 
                85                  90                  95      


Ala Glu Glu Lys Leu Thr His Lys Met Glu Ala Asn Lys Glu Asn Arg 
            100                 105                 110         


Glu Ala Gln Met Ala Ala Lys Leu Glu Arg Leu Arg Glu Lys Asp Lys 
        115                 120                 125             


His Ile Glu Glu Val Arg Lys Asn Lys Glu Ser Lys Asp Pro Ala Asp 
    130                 135                 140                 


Glu Thr Glu Ala Asp 
145                 


<210>  201
<211>  831
<212>  DNA
<213>  Homo sapiens

<400>  201
atgtcatacg gtcccttaga catgtaccgg aacccggggc cctcggggcc ccagctccgg       60

gacttcagca gcatcatcca gacgtgcagc ggcaacatcc agcggatcag ccaagccact      120

gctcagataa agaatttgat gagccagcta ggaactaagc aggactcaag caagctacag      180

gaaaatctgc aacagttaca acactccaca aatcagctcg ccaaggaaac aaatgaattg      240

ctgaaagaat tagggtcctt gccccttccc ttatctactt cagaacagcg ccagcagaga      300

cttcagaagg aacgcctcat gaatgacttc tctgcagcct taaacaattt ccaggctgtg      360

cagagaaggg tatctgaaaa ggaaaaggag agtattgcca gagcaagagc tggatctcgt      420

ctttctgcag aagagaggca aagagaggag cagctggtct catttgacag ccatgaggag      480

tggaaccaga tgcagagcca ggaggatgag gtggccatca ctgagcagga tttggaactt      540

attaaagaaa gagaaacggc aattcggcag ctggaggctg acattttgga tgtcaatcag      600

atatttaaag atttggccat gatgatccat gaccagggtg atctgattga tagcatagaa      660

gccaatgtgg aaagctcaga ggtgcacgtc gaaagagcca ctgaacagtt acagcgagct      720

gcttactatc agaaaaaatc tcgcaagaag atgtgtatcc tggtgcttgt cctgtcagtg      780

attattctaa tcttgggact tattatctgg ctagtttata aaacgaagtg a               831


<210>  202
<211>  276
<212>  PRT
<213>  Homo sapiens

<400>  202

Met Ser Tyr Gly Pro Leu Asp Met Tyr Arg Asn Pro Gly Pro Ser Gly 
1               5                   10                  15      


Pro Gln Leu Arg Asp Phe Ser Ser Ile Ile Gln Thr Cys Ser Gly Asn 
            20                  25                  30          


Ile Gln Arg Ile Ser Gln Ala Thr Ala Gln Ile Lys Asn Leu Met Ser 
        35                  40                  45              


Gln Leu Gly Thr Lys Gln Asp Ser Ser Lys Leu Gln Glu Asn Leu Gln 
    50                  55                  60                  


Gln Leu Gln His Ser Thr Asn Gln Leu Ala Lys Glu Thr Asn Glu Leu 
65                  70                  75                  80  


Leu Lys Glu Leu Gly Ser Leu Pro Leu Pro Leu Ser Thr Ser Glu Gln 
                85                  90                  95      


Arg Gln Gln Arg Leu Gln Lys Glu Arg Leu Met Asn Asp Phe Ser Ala 
            100                 105                 110         


Ala Leu Asn Asn Phe Gln Ala Val Gln Arg Arg Val Ser Glu Lys Glu 
        115                 120                 125             


Lys Glu Ser Ile Ala Arg Ala Arg Ala Gly Ser Arg Leu Ser Ala Glu 
    130                 135                 140                 


Glu Arg Gln Arg Glu Glu Gln Leu Val Ser Phe Asp Ser His Glu Glu 
145                 150                 155                 160 


Trp Asn Gln Met Gln Ser Gln Glu Asp Glu Val Ala Ile Thr Glu Gln 
                165                 170                 175     


Asp Leu Glu Leu Ile Lys Glu Arg Glu Thr Ala Ile Arg Gln Leu Glu 
            180                 185                 190         


Ala Asp Ile Leu Asp Val Asn Gln Ile Phe Lys Asp Leu Ala Met Met 
        195                 200                 205             


Ile His Asp Gln Gly Asp Leu Ile Asp Ser Ile Glu Ala Asn Val Glu 
    210                 215                 220                 


Ser Ser Glu Val His Val Glu Arg Ala Thr Glu Gln Leu Gln Arg Ala 
225                 230                 235                 240 


Ala Tyr Tyr Gln Lys Lys Ser Arg Lys Lys Met Cys Ile Leu Val Leu 
                245                 250                 255     


Val Leu Ser Val Ile Ile Leu Ile Leu Gly Leu Ile Ile Trp Leu Val 
            260                 265                 270         


Tyr Lys Thr Lys 
        275     


<210>  203
<211>  1386
<212>  DNA
<213>  Homo sapiens

<400>  203
atggaggacc tggatgccct gctctctgac ctggagacta ccacctcgca catgccaagg       60

tcaggggctc ccaaagagcg ccctgcggag cctctcaccc ctcccccatc ctatggccac      120

cagccacaga cagggtctgg ggagtcttca ggagcctcgg gggacaagga ccacctgtac      180

agcacggtat gcaagcctcg gtccccaaag cctgcagccc cggcggcccc tccattctcc      240

tcttccagcg gtgtcttggg taccgggctc tgtgagctag atcggttgct tcaggaactt      300

aatgccactc agttcaacat cacagatgaa atcatgtctc agttcccatc tagcaaggtg      360

gcttcaggag agcagaagga ggaccagtct gaagataaga aaagacccag cctcccttcc      420

agcccgtctc ctggcctccc aaaggcttct gccacctcag ccactctgga gctggataga      480

ctgatggcct cactctctga cttccgcgtt caaaaccatc ttccagcctc tgggccaact      540

cagccaccgg tggtgagctc cacaaatgag ggctccccat ccccaccaga gccgactggc      600

aagggcagcc tagacaccat gctggggctg ctgcagtccg acctcagccg ccggggtgtt      660

cccacccagg ccaaaggcct ctgtggctcc tgcaataaac ctattgctgg gcaagtggtg      720

acggctctgg gccgcgcctg gcaccccgag cacttcgttt gcggaggctg ttccaccgcc      780

ctgggaggca gcagcttctt cgagaaggat ggagccccct tctgccccga gtgctacttt      840

gagcgcttct cgccaagatg tggcttctgc aaccagccca tccgacacaa gatggtgacc      900

gccttgggca ctcactggca cccagagcat ttctgctgcg tcagttgcgg ggagcccttc      960

ggagatgagg gtttccacga gcgcgagggc cgcccctact gccgccggga cttcctgcag     1020

ctgttcgccc cgcgctgcca gggctgccag ggccccatcc tggataacta catctcggcg     1080

ctcagcgcgc tctggcaccc ggactgtttc gtctgcaggg aatgcttcgc gcccttctcg     1140

ggaggcagct ttttcgagca cgagggccgc ccgttgtgcg agaaccactt ccacgcacga     1200

cgcggctcgc tgtgcgccac gtgtggcctc cctgtgaccg gccgctgcgt gtcggccctg     1260

ggtcgccgct tccacccgga ccacttcaca tgcaccttct gcctgcgccc gctcaccaag     1320

gggtccttcc aggagcgcgc cggcaagccc tactgccagc cctgcttcct gaagctcttc     1380

ggctga                                                                1386


<210>  204
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  204

Met Glu Asp Leu Asp Ala Leu Leu Ser Asp Leu Glu Thr Thr Thr Ser 
1               5                   10                  15      


His Met Pro Arg Ser Gly Ala Pro Lys Glu Arg Pro Ala Glu Pro Leu 
            20                  25                  30          


Thr Pro Pro Pro Ser Tyr Gly His Gln Pro Gln Thr Gly Ser Gly Glu 
        35                  40                  45              


Ser Ser Gly Ala Ser Gly Asp Lys Asp His Leu Tyr Ser Thr Val Cys 
    50                  55                  60                  


Lys Pro Arg Ser Pro Lys Pro Ala Ala Pro Ala Ala Pro Pro Phe Ser 
65                  70                  75                  80  


Ser Ser Ser Gly Val Leu Gly Thr Gly Leu Cys Glu Leu Asp Arg Leu 
                85                  90                  95      


Leu Gln Glu Leu Asn Ala Thr Gln Phe Asn Ile Thr Asp Glu Ile Met 
            100                 105                 110         


Ser Gln Phe Pro Ser Ser Lys Val Ala Ser Gly Glu Gln Lys Glu Asp 
        115                 120                 125             


Gln Ser Glu Asp Lys Lys Arg Pro Ser Leu Pro Ser Ser Pro Ser Pro 
    130                 135                 140                 


Gly Leu Pro Lys Ala Ser Ala Thr Ser Ala Thr Leu Glu Leu Asp Arg 
145                 150                 155                 160 


Leu Met Ala Ser Leu Ser Asp Phe Arg Val Gln Asn His Leu Pro Ala 
                165                 170                 175     


Ser Gly Pro Thr Gln Pro Pro Val Val Ser Ser Thr Asn Glu Gly Ser 
            180                 185                 190         


Pro Ser Pro Pro Glu Pro Thr Gly Lys Gly Ser Leu Asp Thr Met Leu 
        195                 200                 205             


Gly Leu Leu Gln Ser Asp Leu Ser Arg Arg Gly Val Pro Thr Gln Ala 
    210                 215                 220                 


Lys Gly Leu Cys Gly Ser Cys Asn Lys Pro Ile Ala Gly Gln Val Val 
225                 230                 235                 240 


Thr Ala Leu Gly Arg Ala Trp His Pro Glu His Phe Val Cys Gly Gly 
                245                 250                 255     


Cys Ser Thr Ala Leu Gly Gly Ser Ser Phe Phe Glu Lys Asp Gly Ala 
            260                 265                 270         


Pro Phe Cys Pro Glu Cys Tyr Phe Glu Arg Phe Ser Pro Arg Cys Gly 
        275                 280                 285             


Phe Cys Asn Gln Pro Ile Arg His Lys Met Val Thr Ala Leu Gly Thr 
    290                 295                 300                 


His Trp His Pro Glu His Phe Cys Cys Val Ser Cys Gly Glu Pro Phe 
305                 310                 315                 320 


Gly Asp Glu Gly Phe His Glu Arg Glu Gly Arg Pro Tyr Cys Arg Arg 
                325                 330                 335     


Asp Phe Leu Gln Leu Phe Ala Pro Arg Cys Gln Gly Cys Gln Gly Pro 
            340                 345                 350         


Ile Leu Asp Asn Tyr Ile Ser Ala Leu Ser Ala Leu Trp His Pro Asp 
        355                 360                 365             


Cys Phe Val Cys Arg Glu Cys Phe Ala Pro Phe Ser Gly Gly Ser Phe 
    370                 375                 380                 


Phe Glu His Glu Gly Arg Pro Leu Cys Glu Asn His Phe His Ala Arg 
385                 390                 395                 400 


Arg Gly Ser Leu Cys Ala Thr Cys Gly Leu Pro Val Thr Gly Arg Cys 
                405                 410                 415     


Val Ser Ala Leu Gly Arg Arg Phe His Pro Asp His Phe Thr Cys Thr 
            420                 425                 430         


Phe Cys Leu Arg Pro Leu Thr Lys Gly Ser Phe Gln Glu Arg Ala Gly 
        435                 440                 445             


Lys Pro Tyr Cys Gln Pro Cys Phe Leu Lys Leu Phe Gly 
    450                 455                 460     


<210>  205
<211>  1386
<212>  DNA
<213>  Homo sapiens

<400>  205
atgactccca acagtatgac agaaaatggc cttacagcct gggacaaacc gaagcactgt       60

ccagaccgag aacacgactg gaagctagta ggaatgtctg aagcctgcct acataggaag      120

agccattcag agaggcgcag cacgttgaaa aatgaacagt cgtcgccaca tctcatccag      180

accacttgga ctagctcaat attccatctg gaccatgatg atgtgaacga ccagagtgtc      240

tcaagtgccc agaccttcca aacggaggag aagaaatgta aagggtacat ccccagttac      300

ttagacaagg acgagctctg tgtagtgtgt ggtgacaaag ccaccgggta tcactaccgc      360

tgtatcacgt gtgaaggctg caagggtttc tttagaagaa ccattcagaa aaatctccat      420

ccatcctatt cctgtaaata tgaaggaaaa tgtgtcatag acaaagtcac gcgaaatcag      480

tgccaggaat gtcgctttaa gaaatgcatc tatgttggca tggcaacaga tttggtgctg      540

gatgacagca agaggctggc caagaggaag ctgatagagg agaaccggga gaaaagacgg      600

cgggaagagc tgcagaagtc catcgggcac aagccagagc ccacagacga ggaatgggag      660

ctcatcaaaa ctgtcaccga agcccatgtg gcgaccaacg cccaaggcag ccactggaag      720

caaaaacgga aattcctgcc agaagacatt ggacaagcac caatagtcaa tgccccagaa      780

ggtggaaagg ttgacttgga agccttcagc cattttacaa aaatcatcac accagcaatt      840

accagagtgg tggattttgc caaaaagttg cctatgtttt gtgagctgcc atgtgaagac      900

cagatcatcc tcctcaaagg ctgctgcatg gagatcatgt cccttcgcgc tgctgtgcgc      960

tatgacccag aaagtgagac tttaaccttg aatggggaaa tggcagtgac acggggccag     1020

ctgaaaaatg ggggtcttgg ggtggtgtca gacgccatct ttgacctggg catgtctctg     1080

tcttctttca acctggatga cactgaagta gccctccttc aggccgtcct gctgatgtct     1140

tcagatcgcc cggggcttgc ctgtgttgag agaatagaaa agtaccaaga tagtttcctg     1200

ctggcctttg aacactatat caattaccga aaacaccacg tgacacactt ttggccaaaa     1260

ctcctgatga aggtgacaga tctgcggatg ataggagcct gccatgccag ccgcttcctg     1320

cacatgaagg tggaatgccc cacagaactc ttcccccctt tgttcttgga agtgttcgag     1380

gattag                                                                1386


<210>  206
<211>  461
<212>  PRT
<213>  Homo sapiens

<400>  206

Met Thr Pro Asn Ser Met Thr Glu Asn Gly Leu Thr Ala Trp Asp Lys 
1               5                   10                  15      


Pro Lys His Cys Pro Asp Arg Glu His Asp Trp Lys Leu Val Gly Met 
            20                  25                  30          


Ser Glu Ala Cys Leu His Arg Lys Ser His Ser Glu Arg Arg Ser Thr 
        35                  40                  45              


Leu Lys Asn Glu Gln Ser Ser Pro His Leu Ile Gln Thr Thr Trp Thr 
    50                  55                  60                  


Ser Ser Ile Phe His Leu Asp His Asp Asp Val Asn Asp Gln Ser Val 
65                  70                  75                  80  


Ser Ser Ala Gln Thr Phe Gln Thr Glu Glu Lys Lys Cys Lys Gly Tyr 
                85                  90                  95      


Ile Pro Ser Tyr Leu Asp Lys Asp Glu Leu Cys Val Val Cys Gly Asp 
            100                 105                 110         


Lys Ala Thr Gly Tyr His Tyr Arg Cys Ile Thr Cys Glu Gly Cys Lys 
        115                 120                 125             


Gly Phe Phe Arg Arg Thr Ile Gln Lys Asn Leu His Pro Ser Tyr Ser 
    130                 135                 140                 


Cys Lys Tyr Glu Gly Lys Cys Val Ile Asp Lys Val Thr Arg Asn Gln 
145                 150                 155                 160 


Cys Gln Glu Cys Arg Phe Lys Lys Cys Ile Tyr Val Gly Met Ala Thr 
                165                 170                 175     


Asp Leu Val Leu Asp Asp Ser Lys Arg Leu Ala Lys Arg Lys Leu Ile 
            180                 185                 190         


Glu Glu Asn Arg Glu Lys Arg Arg Arg Glu Glu Leu Gln Lys Ser Ile 
        195                 200                 205             


Gly His Lys Pro Glu Pro Thr Asp Glu Glu Trp Glu Leu Ile Lys Thr 
    210                 215                 220                 


Val Thr Glu Ala His Val Ala Thr Asn Ala Gln Gly Ser His Trp Lys 
225                 230                 235                 240 


Gln Lys Arg Lys Phe Leu Pro Glu Asp Ile Gly Gln Ala Pro Ile Val 
                245                 250                 255     


Asn Ala Pro Glu Gly Gly Lys Val Asp Leu Glu Ala Phe Ser His Phe 
            260                 265                 270         


Thr Lys Ile Ile Thr Pro Ala Ile Thr Arg Val Val Asp Phe Ala Lys 
        275                 280                 285             


Lys Leu Pro Met Phe Cys Glu Leu Pro Cys Glu Asp Gln Ile Ile Leu 
    290                 295                 300                 


Leu Lys Gly Cys Cys Met Glu Ile Met Ser Leu Arg Ala Ala Val Arg 
305                 310                 315                 320 


Tyr Asp Pro Glu Ser Glu Thr Leu Thr Leu Asn Gly Glu Met Ala Val 
                325                 330                 335     


Thr Arg Gly Gln Leu Lys Asn Gly Gly Leu Gly Val Val Ser Asp Ala 
            340                 345                 350         


Ile Phe Asp Leu Gly Met Ser Leu Ser Ser Phe Asn Leu Asp Asp Thr 
        355                 360                 365             


Glu Val Ala Leu Leu Gln Ala Val Leu Leu Met Ser Ser Asp Arg Pro 
    370                 375                 380                 


Gly Leu Ala Cys Val Glu Arg Ile Glu Lys Tyr Gln Asp Ser Phe Leu 
385                 390                 395                 400 


Leu Ala Phe Glu His Tyr Ile Asn Tyr Arg Lys His His Val Thr His 
                405                 410                 415     


Phe Trp Pro Lys Leu Leu Met Lys Val Thr Asp Leu Arg Met Ile Gly 
            420                 425                 430         


Ala Cys His Ala Ser Arg Phe Leu His Met Lys Val Glu Cys Pro Thr 
        435                 440                 445             


Glu Leu Phe Pro Pro Leu Phe Leu Glu Val Phe Glu Asp 
    450                 455                 460     


<210>  207
<211>  636
<212>  DNA
<213>  Homo sapiens

<400>  207
atgacccctt ggctcgggct catcgtgctc ctgggcagct ggagcctggg ggactggggc       60

gccgaggcgt gcacatgctc gcccagccac ccccaggacg ccttctgcaa ctccgacatc      120

gtgatccggg ccaaggtggt ggggaagaag ctggtaaagg aggggccctt cggcacgctg      180

gtctacacca tcaagcagat gaagatgtac cgaggcttca ccaagatgcc ccatgtgcag      240

tacatccata cggaagcttc cgagagtctc tgtggcctta agctggaggt caacaagtac      300

cagtacctgc tgacaggtcg cgtctatgat ggcaagatgt acacggggct gtgcaacttc      360

gtggagaggt gggaccagct caccctctcc cagcgcaagg ggctgaacta tcggtatcac      420

ctgggttgta actgcaagat caagtcctgc tactacctgc cttgctttgt gacttccaag      480

aacgagtgtc tctggaccga catgctctcc aatttcggtt accctggcta ccagtccaaa      540

cactacgcct gcatccggca gaagggcggc tactgcagct ggtaccgagg atgggccccc      600

ccggataaaa gcatcatcaa tgccacagac ccctga                                636


<210>  208
<211>  211
<212>  PRT
<213>  Homo sapiens

<400>  208

Met Thr Pro Trp Leu Gly Leu Ile Val Leu Leu Gly Ser Trp Ser Leu 
1               5                   10                  15      


Gly Asp Trp Gly Ala Glu Ala Cys Thr Cys Ser Pro Ser His Pro Gln 
            20                  25                  30          


Asp Ala Phe Cys Asn Ser Asp Ile Val Ile Arg Ala Lys Val Val Gly 
        35                  40                  45              


Lys Lys Leu Val Lys Glu Gly Pro Phe Gly Thr Leu Val Tyr Thr Ile 
    50                  55                  60                  


Lys Gln Met Lys Met Tyr Arg Gly Phe Thr Lys Met Pro His Val Gln 
65                  70                  75                  80  


Tyr Ile His Thr Glu Ala Ser Glu Ser Leu Cys Gly Leu Lys Leu Glu 
                85                  90                  95      


Val Asn Lys Tyr Gln Tyr Leu Leu Thr Gly Arg Val Tyr Asp Gly Lys 
            100                 105                 110         


Met Tyr Thr Gly Leu Cys Asn Phe Val Glu Arg Trp Asp Gln Leu Thr 
        115                 120                 125             


Leu Ser Gln Arg Lys Gly Leu Asn Tyr Arg Tyr His Leu Gly Cys Asn 
    130                 135                 140                 


Cys Lys Ile Lys Ser Cys Tyr Tyr Leu Pro Cys Phe Val Thr Ser Lys 
145                 150                 155                 160 


Asn Glu Cys Leu Trp Thr Asp Met Leu Ser Asn Phe Gly Tyr Pro Gly 
                165                 170                 175     


Tyr Gln Ser Lys His Tyr Ala Cys Ile Arg Gln Lys Gly Gly Tyr Cys 
            180                 185                 190         


Ser Trp Tyr Arg Gly Trp Ala Pro Pro Asp Lys Ser Ile Ile Asn Ala 
        195                 200                 205             


Thr Asp Pro 
    210     


<210>  209
<211>  2085
<212>  DNA
<213>  Homo sapiens

<400>  209
atgccggagt tcctggaaga cccctcggtc ctgacaaaag acaagttgaa gagtgagttg       60

gtcgccaaca atgtgacgct gccggccggg gagcagcgca aagacgtgta cgtccagctc      120

tacctgcagc acctcacggc tcgcaaccgg ccgccgctcc ccgccggcac caacagcaag      180

gggcccccgg acttctccag tgacgaagag cgcgagccca ccccggtcct cggctctggg      240

gccgccgccg cgggccggag ccgagcagcc gtcggcagga aagccacaaa aaaaactgat      300

aaacccagac aagaagataa agatgatcta gatgtaacag agctcactaa tgaagatctt      360

ttggatcagc ttgtgaaata cggagtgaat cctggtccta ttgtgggaac aaccaggaag      420

ctatatgaga aaaagctttt gaaactgagg gaacaaggaa cagaatcaag atcttctact      480

cctctgccaa caatttcttc ttcagcagaa aatacaaggc agaatggaag taatgattct      540

gacagataca gtgacaatga agaaggaaag aagaaagaac acaagaaagt gaagtccact      600

agggatattg ttcctttttc tgaacttgga actactccct ctggtggtgg attttttcag      660

ggtatttctt ttcctgaaat ctccacccgt cctcctttgg gcagtaccga actacaggca      720

gctaagaaag tacatacttc taagggagac ctacctaggg agcctcttgt tgccacaaac      780

ttgcctggca ggggacagtt gcagaagtta gcctctgaaa ggaatttgtt tatttcatgc      840

aagtctagcc atgataggtg tttagagaaa agttcttcgt catcttctca gcctgaacac      900

agtgccatgt tggtctctac tgcagcttct ccttcactga ttaaagaaac caccactggt      960

tactataaag acatagtaga aaatatttgc ggtagagaga aaagtggaat tcaaccatta     1020

tgtcctgaga ggtcccatat ttcagatcaa tcgcctctct ccagtaaaag gaaagcacta     1080

gaagagtctg agagctcaca actaatttct ccgccacttg cccaggcaat cagagattat     1140

gtcaattctc tgttggtcca gggtggggta ggtagtttgc ctggaacttc taactctatg     1200

cccccactgg atgtagaaaa catacagaag agaattgatc agtctaagtt tcaagaaact     1260

gaattcctgt ctcctccaag aaaagtccct agactgagtg agaagtcagt ggaggaaagg     1320

gattcaggtt cctttgtggc atttcagaac atacctggat ccgaactgat gtcttctttt     1380

gccaaaactg ttgtctctca ttcactcact accttaggtc tagaagtggc taagcaatca     1440

cagcatgata aaatagatgc ctcagaacta tcttttccct tccatgaatc tattttaaaa     1500

gtaattgaag aagaatggca gcaagttgac aggcagctgc cttcactggc atgcaaatat     1560

ccagtttctt ccagggaggc aacacagata ttatcagttc caaaagtaga tgatgaaatc     1620

ctagggttta tttctgaagc cactccacta ggaggtattc aagcagcctc cactgagtct     1680

tgcaatcagc agttggactt agcactctgt agagcatatg aagctgcagc atcagcattg     1740

cagattgcaa ctcacactgc ctttgtagct aaggctatgc aggcagacat tagtcaagct     1800

gcacagattc ttagctcaga tcctagtcgt acccaccaag cgcttgggat tctgagcaaa     1860

acatatgatg cagcctcata tatttgtgaa gctgcatttg atgaagtgaa gatggctgcc     1920

cataccatgg gaaatgccac tgtaggtcgt cgatacctct ggctgaagga ttgcaaaatt     1980

aatttagctt ctaagaataa gctggcttcc actcccttta aaggtggaac attatttgga     2040

ggagaagtat gcaaagtaat taaaaagcgt ggaaataaac actag                     2085


<210>  210
<211>  694
<212>  PRT
<213>  Homo sapiens

<400>  210

Met Pro Glu Phe Leu Glu Asp Pro Ser Val Leu Thr Lys Asp Lys Leu 
1               5                   10                  15      


Lys Ser Glu Leu Val Ala Asn Asn Val Thr Leu Pro Ala Gly Glu Gln 
            20                  25                  30          


Arg Lys Asp Val Tyr Val Gln Leu Tyr Leu Gln His Leu Thr Ala Arg 
        35                  40                  45              


Asn Arg Pro Pro Leu Pro Ala Gly Thr Asn Ser Lys Gly Pro Pro Asp 
    50                  55                  60                  


Phe Ser Ser Asp Glu Glu Arg Glu Pro Thr Pro Val Leu Gly Ser Gly 
65                  70                  75                  80  


Ala Ala Ala Ala Gly Arg Ser Arg Ala Ala Val Gly Arg Lys Ala Thr 
                85                  90                  95      


Lys Lys Thr Asp Lys Pro Arg Gln Glu Asp Lys Asp Asp Leu Asp Val 
            100                 105                 110         


Thr Glu Leu Thr Asn Glu Asp Leu Leu Asp Gln Leu Val Lys Tyr Gly 
        115                 120                 125             


Val Asn Pro Gly Pro Ile Val Gly Thr Thr Arg Lys Leu Tyr Glu Lys 
    130                 135                 140                 


Lys Leu Leu Lys Leu Arg Glu Gln Gly Thr Glu Ser Arg Ser Ser Thr 
145                 150                 155                 160 


Pro Leu Pro Thr Ile Ser Ser Ser Ala Glu Asn Thr Arg Gln Asn Gly 
                165                 170                 175     


Ser Asn Asp Ser Asp Arg Tyr Ser Asp Asn Glu Glu Gly Lys Lys Lys 
            180                 185                 190         


Glu His Lys Lys Val Lys Ser Thr Arg Asp Ile Val Pro Phe Ser Glu 
        195                 200                 205             


Leu Gly Thr Thr Pro Ser Gly Gly Gly Phe Phe Gln Gly Ile Ser Phe 
    210                 215                 220                 


Pro Glu Ile Ser Thr Arg Pro Pro Leu Gly Ser Thr Glu Leu Gln Ala 
225                 230                 235                 240 


Ala Lys Lys Val His Thr Ser Lys Gly Asp Leu Pro Arg Glu Pro Leu 
                245                 250                 255     


Val Ala Thr Asn Leu Pro Gly Arg Gly Gln Leu Gln Lys Leu Ala Ser 
            260                 265                 270         


Glu Arg Asn Leu Phe Ile Ser Cys Lys Ser Ser His Asp Arg Cys Leu 
        275                 280                 285             


Glu Lys Ser Ser Ser Ser Ser Ser Gln Pro Glu His Ser Ala Met Leu 
    290                 295                 300                 


Val Ser Thr Ala Ala Ser Pro Ser Leu Ile Lys Glu Thr Thr Thr Gly 
305                 310                 315                 320 


Tyr Tyr Lys Asp Ile Val Glu Asn Ile Cys Gly Arg Glu Lys Ser Gly 
                325                 330                 335     


Ile Gln Pro Leu Cys Pro Glu Arg Ser His Ile Ser Asp Gln Ser Pro 
            340                 345                 350         


Leu Ser Ser Lys Arg Lys Ala Leu Glu Glu Ser Glu Ser Ser Gln Leu 
        355                 360                 365             


Ile Ser Pro Pro Leu Ala Gln Ala Ile Arg Asp Tyr Val Asn Ser Leu 
    370                 375                 380                 


Leu Val Gln Gly Gly Val Gly Ser Leu Pro Gly Thr Ser Asn Ser Met 
385                 390                 395                 400 


Pro Pro Leu Asp Val Glu Asn Ile Gln Lys Arg Ile Asp Gln Ser Lys 
                405                 410                 415     


Phe Gln Glu Thr Glu Phe Leu Ser Pro Pro Arg Lys Val Pro Arg Leu 
            420                 425                 430         


Ser Glu Lys Ser Val Glu Glu Arg Asp Ser Gly Ser Phe Val Ala Phe 
        435                 440                 445             


Gln Asn Ile Pro Gly Ser Glu Leu Met Ser Ser Phe Ala Lys Thr Val 
    450                 455                 460                 


Val Ser His Ser Leu Thr Thr Leu Gly Leu Glu Val Ala Lys Gln Ser 
465                 470                 475                 480 


Gln His Asp Lys Ile Asp Ala Ser Glu Leu Ser Phe Pro Phe His Glu 
                485                 490                 495     


Ser Ile Leu Lys Val Ile Glu Glu Glu Trp Gln Gln Val Asp Arg Gln 
            500                 505                 510         


Leu Pro Ser Leu Ala Cys Lys Tyr Pro Val Ser Ser Arg Glu Ala Thr 
        515                 520                 525             


Gln Ile Leu Ser Val Pro Lys Val Asp Asp Glu Ile Leu Gly Phe Ile 
    530                 535                 540                 


Ser Glu Ala Thr Pro Leu Gly Gly Ile Gln Ala Ala Ser Thr Glu Ser 
545                 550                 555                 560 


Cys Asn Gln Gln Leu Asp Leu Ala Leu Cys Arg Ala Tyr Glu Ala Ala 
                565                 570                 575     


Ala Ser Ala Leu Gln Ile Ala Thr His Thr Ala Phe Val Ala Lys Ala 
            580                 585                 590         


Met Gln Ala Asp Ile Ser Gln Ala Ala Gln Ile Leu Ser Ser Asp Pro 
        595                 600                 605             


Ser Arg Thr His Gln Ala Leu Gly Ile Leu Ser Lys Thr Tyr Asp Ala 
    610                 615                 620                 


Ala Ser Tyr Ile Cys Glu Ala Ala Phe Asp Glu Val Lys Met Ala Ala 
625                 630                 635                 640 


His Thr Met Gly Asn Ala Thr Val Gly Arg Arg Tyr Leu Trp Leu Lys 
                645                 650                 655     


Asp Cys Lys Ile Asn Leu Ala Ser Lys Asn Lys Leu Ala Ser Thr Pro 
            660                 665                 670         


Phe Lys Gly Gly Thr Leu Phe Gly Gly Glu Val Cys Lys Val Ile Lys 
        675                 680                 685             


Lys Arg Gly Asn Lys His 
    690                 


<210>  211
<211>  1272
<212>  DNA
<213>  Homo sapiens

<400>  211
atggctttaa aagtgctact agaacaagag aaaacgtttt tcactctttt agtattacta       60

ggctatttgt catgtaaagt gacttgtgaa tcaggagact gtagacagca agaattcagg      120

gatcggtctg gaaactgtgt tccctgcaac cagtgtgggc caggcatgga gttgtctaag      180

gaatgtggct tcggctatgg ggaggatgca cagtgtgtga cgtgccggct gcacaggttc      240

aaggaggact ggggcttcca gaaatgcaag ccctgtctgg actgcgcagt ggtgaaccgc      300

tttcagaagg caaattgttc agccaccagt gatgccatct gcggggactg cttgccagga      360

ttttatagga agacgaaact tgtcggcttt caagacatgg agtgtgtgcc ttgtggagac      420

cctcctcctc cttacgaacc gcactgtgcc agcaaggtca acctcgtgaa gatcgcgtcc      480

acggcctcca gcccacggga cacggcgctg gctgccgtta tctgcagcgc tctggccacc      540

gtcctgctgg ccctgctcat cctctgtgtc atctattgta agagacagtt tatggagaag      600

aaacccagct ggtctctgcg gtcacaggac attcagtaca acggctctga gctgtcgtgt      660

tttgacagac ctcagctcca cgaatatgcc cacagagcct gctgccagtg ccgccgtgac      720

tcagtgcaga cctgcgggcc ggtgcgcttg ctcccatcca tgtgctgtga ggaggcctgc      780

agccccaacc cggcgactct tggttgtggg gtgcattctg cagccagtct tcaggcaaga      840

aacgcaggcc cagccgggga gatggtgccg actttcttcg gatccctcac gcagtccatc      900

tgtggcgagt tttcagatgc ctggcctctg atgcagaatc ccatgggtgg tgacaacatc      960

tctttttgtg actcttatcc tgaactcact ggagaagaca ttcattctct caatccagaa     1020

cttgaaagct caacgtcttt ggattcaaat agcagtcaag atttggttgg tggggctgtt     1080

ccagtccagt ctcattctga aaactttaca gcagctactg atttatctag atataacaac     1140

acactggtag aatcagcatc aactcaggat gcactaacta tgagaagcca gctagatcag     1200

gagagtggtg ctgtcatcca cccagccact cagacgtccc tccaggtaag gcagcgactg     1260

ggttccctgt ga                                                         1272


<210>  212
<211>  423
<212>  PRT
<213>  Homo sapiens

<400>  212

Met Ala Leu Lys Val Leu Leu Glu Gln Glu Lys Thr Phe Phe Thr Leu 
1               5                   10                  15      


Leu Val Leu Leu Gly Tyr Leu Ser Cys Lys Val Thr Cys Glu Ser Gly 
            20                  25                  30          


Asp Cys Arg Gln Gln Glu Phe Arg Asp Arg Ser Gly Asn Cys Val Pro 
        35                  40                  45              


Cys Asn Gln Cys Gly Pro Gly Met Glu Leu Ser Lys Glu Cys Gly Phe 
    50                  55                  60                  


Gly Tyr Gly Glu Asp Ala Gln Cys Val Thr Cys Arg Leu His Arg Phe 
65                  70                  75                  80  


Lys Glu Asp Trp Gly Phe Gln Lys Cys Lys Pro Cys Leu Asp Cys Ala 
                85                  90                  95      


Val Val Asn Arg Phe Gln Lys Ala Asn Cys Ser Ala Thr Ser Asp Ala 
            100                 105                 110         


Ile Cys Gly Asp Cys Leu Pro Gly Phe Tyr Arg Lys Thr Lys Leu Val 
        115                 120                 125             


Gly Phe Gln Asp Met Glu Cys Val Pro Cys Gly Asp Pro Pro Pro Pro 
    130                 135                 140                 


Tyr Glu Pro His Cys Ala Ser Lys Val Asn Leu Val Lys Ile Ala Ser 
145                 150                 155                 160 


Thr Ala Ser Ser Pro Arg Asp Thr Ala Leu Ala Ala Val Ile Cys Ser 
                165                 170                 175     


Ala Leu Ala Thr Val Leu Leu Ala Leu Leu Ile Leu Cys Val Ile Tyr 
            180                 185                 190         


Cys Lys Arg Gln Phe Met Glu Lys Lys Pro Ser Trp Ser Leu Arg Ser 
        195                 200                 205             


Gln Asp Ile Gln Tyr Asn Gly Ser Glu Leu Ser Cys Phe Asp Arg Pro 
    210                 215                 220                 


Gln Leu His Glu Tyr Ala His Arg Ala Cys Cys Gln Cys Arg Arg Asp 
225                 230                 235                 240 


Ser Val Gln Thr Cys Gly Pro Val Arg Leu Leu Pro Ser Met Cys Cys 
                245                 250                 255     


Glu Glu Ala Cys Ser Pro Asn Pro Ala Thr Leu Gly Cys Gly Val His 
            260                 265                 270         


Ser Ala Ala Ser Leu Gln Ala Arg Asn Ala Gly Pro Ala Gly Glu Met 
        275                 280                 285             


Val Pro Thr Phe Phe Gly Ser Leu Thr Gln Ser Ile Cys Gly Glu Phe 
    290                 295                 300                 


Ser Asp Ala Trp Pro Leu Met Gln Asn Pro Met Gly Gly Asp Asn Ile 
305                 310                 315                 320 


Ser Phe Cys Asp Ser Tyr Pro Glu Leu Thr Gly Glu Asp Ile His Ser 
                325                 330                 335     


Leu Asn Pro Glu Leu Glu Ser Ser Thr Ser Leu Asp Ser Asn Ser Ser 
            340                 345                 350         


Gln Asp Leu Val Gly Gly Ala Val Pro Val Gln Ser His Ser Glu Asn 
        355                 360                 365             


Phe Thr Ala Ala Thr Asp Leu Ser Arg Tyr Asn Asn Thr Leu Val Glu 
    370                 375                 380                 


Ser Ala Ser Thr Gln Asp Ala Leu Thr Met Arg Ser Gln Leu Asp Gln 
385                 390                 395                 400 


Glu Ser Gly Ala Val Ile His Pro Ala Thr Gln Thr Ser Leu Gln Val 
                405                 410                 415     


Arg Gln Arg Leu Gly Ser Leu 
            420             


<210>  213
<211>  4596
<212>  DNA
<213>  Homo sapiens

<400>  213
atggaagtgt caccattgca gcctgtaaat gaaaatatgc aagtcaacaa aataaagaaa       60

aatgaagatg ctaagaaaag actgtctgtt gaaagaatct atcaaaagaa aacacaattg      120

gaacatattt tgctccgccc agacacctac attggttctg tggaattagt gacccagcaa      180

atgtgggttt acgatgaaga tgttggcatt aactataggg aagtcacttt tgttcctggt      240

ttgtacaaaa tctttgatga gattctagtt aatgctgcgg acaacaaaca aagggaccca      300

aaaatgtctt gtattagagt cacaattgat ccggaaaaca atttaattag tatatggaat      360

aatggaaaag gtattcctgt tgttgaacac aaagttgaaa agatgtatgt cccagctctc      420

atatttggac agctcctaac ttctagtaac tatgatgatg atgaaaagaa agtgacaggt      480

ggtcgaaatg gctatggagc caaattgtgt aacatattca gtaccaaatt tactgtggaa      540

acagccagta gagaatacaa gaaaatgttc aaacagacat ggatggataa tatgggaaga      600

gctggtgaga tggaactcaa gcccttcaat ggagaagatt atacatgtat cacctttcag      660

cctgatttgt ctaagtttaa aatgcaaagc ctggacaaag atattgttgc actaatggtc      720

agaagagcat atgatattgc tggatccacc aaagatgtca aagtctttct taatggaaat      780

aaactgccag taaaaggatt tcgtagttat gtggacatgt atttgaagga caagttggat      840

gaaactggta actccttgaa agtaatacat gaacaagtaa accacaggtg ggaagtgtgt      900

ttaactatga gtgaaaaagg ctttcagcaa attagctttg tcaacagcat tgctacatcc      960

aagggtggca gacatgttga ttatgtagct gatcagattg tgactaaact tgttgatgtt     1020

gtgaagaaga agaacaaggg tggtgttgca gtaaaagcac atcaggtgaa aaatcacatg     1080

tggatttttg taaatgcctt aattgaaaac ccaacctttg actctcagac aaaagaaaac     1140

atgactttac aacccaagag ctttggatca acatgccaat tgagtgaaaa atttatcaaa     1200

gctgccattg gctgtggtat tgtagaaagc atactaaact gggtgaagtt taaggcccaa     1260

gtccagttaa acaagaagtg ttcagctgta aaacataata gaatcaaggg aattcccaaa     1320

ctcgatgatg ccaatgatgc agggggccga aactccactg agtgtacgct tatcctgact     1380

gagggagatt cagccaaaac tttggctgtt tcaggccttg gtgtggttgg gagagacaaa     1440

tatggggttt tccctcttag aggaaaaata ctcaatgttc gagaagcttc tcataagcag     1500

atcatggaaa atgctgagat taacaatatc atcaagattg tgggtcttca gtacaagaaa     1560

aactatgaag atgaagattc attgaagacg cttcgttatg ggaagataat gattatgaca     1620

gatcaggacc aagatggttc ccacatcaaa ggcttgctga ttaattttat ccatcacaac     1680

tggccctctc ttctgcgaca tcgttttctg gaggaattta tcactcccat tgtaaaggta     1740

tctaaaaaca agcaagaaat ggcattttac agccttcctg aatttgaaga gtggaagagt     1800

tctactccaa atcataaaaa atggaaagtc aaatattaca aaggtttggg caccagcaca     1860

tcaaaggaag ctaaagaata ctttgcagat atgaaaagac atcgtatcca gttcaaatat     1920

tctggtcctg aagatgatgc tgctatcagc ctggccttta gcaaaaaaca gatagatgat     1980

cgaaaggaat ggttaactaa tttcatggag gatagaagac aacgaaagtt acttgggctt     2040

cctgaggatt acttgtatgg acaaactacc acatatctga catataatga cttcatcaac     2100

aaggaactta tcttgttctc aaattctgat aacgagagat ctatcccttc tatggtggat     2160

ggtttgaaac caggtcagag aaaggttttg tttacttgct tcaaacggaa tgacaagcga     2220

gaagtaaagg ttgcccaatt agctggatca gtggctgaaa tgtcttctta tcatcatggt     2280

gagatgtcac taatgatgac cattatcaat ttggctcaga attttgtggg tagcaataat     2340

ctaaacctct tgcagcccat tggtcagttt ggtaccaggc tacatggtgg caaggattct     2400

gctagtccac gatacatctt tacaatgctc agctctttgg ctcgattgtt atttccacca     2460

aaagatgatc acacgttgaa gtttttatat gatgacaacc agcgtgttga gcctgaatgg     2520

tacattccta ttattcccat ggtgctgata aatggtgctg aaggaatcgg tactgggtgg     2580

tcctgcaaaa tccccaactt tgatgtgcgt gaaattgtaa ataacatcag gcgtttgatg     2640

gatggagaag aacctttgcc aatgcttcca agttacaaga acttcaaggg tactattgaa     2700

gaactggctc caaatcaata tgtgattagt ggtgaagtag ctattcttaa ttctacaacc     2760

attgaaatct cagagcttcc cgtcagaaca tggacccaga catacaaaga acaagttcta     2820

gaacccatgt tgaatggcac cgagaagaca cctcctctca taacagacta tagggaatac     2880

catacagata ccactgtgaa atttgttgtg aagatgactg aagaaaaact ggcagaggca     2940

gagagagttg gactacacaa agtcttcaaa ctccaaacta gtctcacatg caactctatg     3000

gtgctttttg accacgtagg ctgtttaaag aaatatgaca cggtgttgga tattctaaga     3060

gacttttttg aactcagact taaatattat ggattaagaa aagaatggct cctaggaatg     3120

cttggtgctg aatctgctaa actgaataat caggctcgct ttatcttaga gaaaatagat     3180

ggcaaaataa tcattgaaaa taagcctaag aaagaattaa ttaaagttct gattcagagg     3240

ggatatgatt cggatcctgt gaaggcctgg aaagaagccc agcaaaaggt tccagatgaa     3300

gaagaaaatg aagagagtga caacgaaaag gaaactgaaa agagtgactc cgtaacagat     3360

tctggaccaa ccttcaacta tcttcttgat atgccccttt ggtatttaac caaggaaaag     3420

aaagatgaac tctgcaggct aagaaatgaa aaagaacaag agctggacac attaaaaaga     3480

aagagtccat cagatttgtg gaaagaagac ttggctacat ttattgaaga attggaggct     3540

gttgaagcca aggaaaaaca agatgaacaa gtcggacttc ctgggaaagg ggggaaggcc     3600

aaggggaaaa aaacacaaat ggctgaagtt ttgccttctc cgcgtggtca aagagtcatt     3660

ccacgaataa ccatagaaat gaaagcagag gcagaaaaga aaaataaaaa gaaaattaag     3720

aatgaaaata ctgaaggaag ccctcaagaa gatggtgtgg aactagaagg cctaaaacaa     3780

agattagaaa agaaacagaa aagagaacca ggtacaaaga caaagaaaca aactacattg     3840

gcatttaagc caatcaaaaa aggaaagaag agaaatccct ggtctgattc agaatcagat     3900

aggagcagtg acgaaagtaa ttttgatgtc cctccacgag aaacagagcc acggagagca     3960

gcaacaaaaa caaaattcac aatggatttg gattcagatg aagatttctc agattttgat     4020

gaaaaaactg atgatgaaga ttttgtccca tcagatgcta gtccacctaa gaccaaaact     4080

tccccaaaac ttagtaacaa agaactgaaa ccacagaaaa gtgtcgtgtc agaccttgaa     4140

gctgatgatg ttaagggcag tgtaccactg tcttcaagcc ctcctgctac acatttccca     4200

gatgaaactg aaattacaaa cccagttcct aaaaagaatg tgacagtgaa gaagacagca     4260

gcaaaaagtc agtcttccac ctccactacc ggtgccaaaa aaagggctgc cccaaaagga     4320

actaaaaggg atccagcttt gaattctggt gtctctcaaa agcctgatcc tgccaaaacc     4380

aagaatcgcc gcaaaaggaa gccatccact tctgatgatt ctgactctaa ttttgagaaa     4440

attgtttcga aagcagtcac aagcaagaaa tccaaggggg agagtgatga cttccatatg     4500

gactttgact cagctgtggc tcctcgggca aaatctgtac gggcaaagaa acctataaag     4560

tacctggaag agtcagatga agatgatctg ttttaa                               4596


<210>  214
<211>  1531
<212>  PRT
<213>  Homo sapiens

<400>  214

Met Glu Val Ser Pro Leu Gln Pro Val Asn Glu Asn Met Gln Val Asn 
1               5                   10                  15      


Lys Ile Lys Lys Asn Glu Asp Ala Lys Lys Arg Leu Ser Val Glu Arg 
            20                  25                  30          


Ile Tyr Gln Lys Lys Thr Gln Leu Glu His Ile Leu Leu Arg Pro Asp 
        35                  40                  45              


Thr Tyr Ile Gly Ser Val Glu Leu Val Thr Gln Gln Met Trp Val Tyr 
    50                  55                  60                  


Asp Glu Asp Val Gly Ile Asn Tyr Arg Glu Val Thr Phe Val Pro Gly 
65                  70                  75                  80  


Leu Tyr Lys Ile Phe Asp Glu Ile Leu Val Asn Ala Ala Asp Asn Lys 
                85                  90                  95      


Gln Arg Asp Pro Lys Met Ser Cys Ile Arg Val Thr Ile Asp Pro Glu 
            100                 105                 110         


Asn Asn Leu Ile Ser Ile Trp Asn Asn Gly Lys Gly Ile Pro Val Val 
        115                 120                 125             


Glu His Lys Val Glu Lys Met Tyr Val Pro Ala Leu Ile Phe Gly Gln 
    130                 135                 140                 


Leu Leu Thr Ser Ser Asn Tyr Asp Asp Asp Glu Lys Lys Val Thr Gly 
145                 150                 155                 160 


Gly Arg Asn Gly Tyr Gly Ala Lys Leu Cys Asn Ile Phe Ser Thr Lys 
                165                 170                 175     


Phe Thr Val Glu Thr Ala Ser Arg Glu Tyr Lys Lys Met Phe Lys Gln 
            180                 185                 190         


Thr Trp Met Asp Asn Met Gly Arg Ala Gly Glu Met Glu Leu Lys Pro 
        195                 200                 205             


Phe Asn Gly Glu Asp Tyr Thr Cys Ile Thr Phe Gln Pro Asp Leu Ser 
    210                 215                 220                 


Lys Phe Lys Met Gln Ser Leu Asp Lys Asp Ile Val Ala Leu Met Val 
225                 230                 235                 240 


Arg Arg Ala Tyr Asp Ile Ala Gly Ser Thr Lys Asp Val Lys Val Phe 
                245                 250                 255     


Leu Asn Gly Asn Lys Leu Pro Val Lys Gly Phe Arg Ser Tyr Val Asp 
            260                 265                 270         


Met Tyr Leu Lys Asp Lys Leu Asp Glu Thr Gly Asn Ser Leu Lys Val 
        275                 280                 285             


Ile His Glu Gln Val Asn His Arg Trp Glu Val Cys Leu Thr Met Ser 
    290                 295                 300                 


Glu Lys Gly Phe Gln Gln Ile Ser Phe Val Asn Ser Ile Ala Thr Ser 
305                 310                 315                 320 


Lys Gly Gly Arg His Val Asp Tyr Val Ala Asp Gln Ile Val Thr Lys 
                325                 330                 335     


Leu Val Asp Val Val Lys Lys Lys Asn Lys Gly Gly Val Ala Val Lys 
            340                 345                 350         


Ala His Gln Val Lys Asn His Met Trp Ile Phe Val Asn Ala Leu Ile 
        355                 360                 365             


Glu Asn Pro Thr Phe Asp Ser Gln Thr Lys Glu Asn Met Thr Leu Gln 
    370                 375                 380                 


Pro Lys Ser Phe Gly Ser Thr Cys Gln Leu Ser Glu Lys Phe Ile Lys 
385                 390                 395                 400 


Ala Ala Ile Gly Cys Gly Ile Val Glu Ser Ile Leu Asn Trp Val Lys 
                405                 410                 415     


Phe Lys Ala Gln Val Gln Leu Asn Lys Lys Cys Ser Ala Val Lys His 
            420                 425                 430         


Asn Arg Ile Lys Gly Ile Pro Lys Leu Asp Asp Ala Asn Asp Ala Gly 
        435                 440                 445             


Gly Arg Asn Ser Thr Glu Cys Thr Leu Ile Leu Thr Glu Gly Asp Ser 
    450                 455                 460                 


Ala Lys Thr Leu Ala Val Ser Gly Leu Gly Val Val Gly Arg Asp Lys 
465                 470                 475                 480 


Tyr Gly Val Phe Pro Leu Arg Gly Lys Ile Leu Asn Val Arg Glu Ala 
                485                 490                 495     


Ser His Lys Gln Ile Met Glu Asn Ala Glu Ile Asn Asn Ile Ile Lys 
            500                 505                 510         


Ile Val Gly Leu Gln Tyr Lys Lys Asn Tyr Glu Asp Glu Asp Ser Leu 
        515                 520                 525             


Lys Thr Leu Arg Tyr Gly Lys Ile Met Ile Met Thr Asp Gln Asp Gln 
    530                 535                 540                 


Asp Gly Ser His Ile Lys Gly Leu Leu Ile Asn Phe Ile His His Asn 
545                 550                 555                 560 


Trp Pro Ser Leu Leu Arg His Arg Phe Leu Glu Glu Phe Ile Thr Pro 
                565                 570                 575     


Ile Val Lys Val Ser Lys Asn Lys Gln Glu Met Ala Phe Tyr Ser Leu 
            580                 585                 590         


Pro Glu Phe Glu Glu Trp Lys Ser Ser Thr Pro Asn His Lys Lys Trp 
        595                 600                 605             


Lys Val Lys Tyr Tyr Lys Gly Leu Gly Thr Ser Thr Ser Lys Glu Ala 
    610                 615                 620                 


Lys Glu Tyr Phe Ala Asp Met Lys Arg His Arg Ile Gln Phe Lys Tyr 
625                 630                 635                 640 


Ser Gly Pro Glu Asp Asp Ala Ala Ile Ser Leu Ala Phe Ser Lys Lys 
                645                 650                 655     


Gln Ile Asp Asp Arg Lys Glu Trp Leu Thr Asn Phe Met Glu Asp Arg 
            660                 665                 670         


Arg Gln Arg Lys Leu Leu Gly Leu Pro Glu Asp Tyr Leu Tyr Gly Gln 
        675                 680                 685             


Thr Thr Thr Tyr Leu Thr Tyr Asn Asp Phe Ile Asn Lys Glu Leu Ile 
    690                 695                 700                 


Leu Phe Ser Asn Ser Asp Asn Glu Arg Ser Ile Pro Ser Met Val Asp 
705                 710                 715                 720 


Gly Leu Lys Pro Gly Gln Arg Lys Val Leu Phe Thr Cys Phe Lys Arg 
                725                 730                 735     


Asn Asp Lys Arg Glu Val Lys Val Ala Gln Leu Ala Gly Ser Val Ala 
            740                 745                 750         


Glu Met Ser Ser Tyr His His Gly Glu Met Ser Leu Met Met Thr Ile 
        755                 760                 765             


Ile Asn Leu Ala Gln Asn Phe Val Gly Ser Asn Asn Leu Asn Leu Leu 
    770                 775                 780                 


Gln Pro Ile Gly Gln Phe Gly Thr Arg Leu His Gly Gly Lys Asp Ser 
785                 790                 795                 800 


Ala Ser Pro Arg Tyr Ile Phe Thr Met Leu Ser Ser Leu Ala Arg Leu 
                805                 810                 815     


Leu Phe Pro Pro Lys Asp Asp His Thr Leu Lys Phe Leu Tyr Asp Asp 
            820                 825                 830         


Asn Gln Arg Val Glu Pro Glu Trp Tyr Ile Pro Ile Ile Pro Met Val 
        835                 840                 845             


Leu Ile Asn Gly Ala Glu Gly Ile Gly Thr Gly Trp Ser Cys Lys Ile 
    850                 855                 860                 


Pro Asn Phe Asp Val Arg Glu Ile Val Asn Asn Ile Arg Arg Leu Met 
865                 870                 875                 880 


Asp Gly Glu Glu Pro Leu Pro Met Leu Pro Ser Tyr Lys Asn Phe Lys 
                885                 890                 895     


Gly Thr Ile Glu Glu Leu Ala Pro Asn Gln Tyr Val Ile Ser Gly Glu 
            900                 905                 910         


Val Ala Ile Leu Asn Ser Thr Thr Ile Glu Ile Ser Glu Leu Pro Val 
        915                 920                 925             


Arg Thr Trp Thr Gln Thr Tyr Lys Glu Gln Val Leu Glu Pro Met Leu 
    930                 935                 940                 


Asn Gly Thr Glu Lys Thr Pro Pro Leu Ile Thr Asp Tyr Arg Glu Tyr 
945                 950                 955                 960 


His Thr Asp Thr Thr Val Lys Phe Val Val Lys Met Thr Glu Glu Lys 
                965                 970                 975     


Leu Ala Glu Ala Glu Arg Val Gly Leu His Lys Val Phe Lys Leu Gln 
            980                 985                 990         


Thr Ser Leu Thr Cys Asn Ser Met  Val Leu Phe Asp His  Val Gly Cys 
        995                 1000                 1005             


Leu Lys  Lys Tyr Asp Thr Val  Leu Asp Ile Leu Arg  Asp Phe Phe 
    1010                 1015                 1020             


Glu Leu  Arg Leu Lys Tyr Tyr  Gly Leu Arg Lys Glu  Trp Leu Leu 
    1025                 1030                 1035             


Gly Met  Leu Gly Ala Glu Ser  Ala Lys Leu Asn Asn  Gln Ala Arg 
    1040                 1045                 1050             


Phe Ile  Leu Glu Lys Ile Asp  Gly Lys Ile Ile Ile  Glu Asn Lys 
    1055                 1060                 1065             


Pro Lys  Lys Glu Leu Ile Lys  Val Leu Ile Gln Arg  Gly Tyr Asp 
    1070                 1075                 1080             


Ser Asp  Pro Val Lys Ala Trp  Lys Glu Ala Gln Gln  Lys Val Pro 
    1085                 1090                 1095             


Asp Glu  Glu Glu Asn Glu Glu  Ser Asp Asn Glu Lys  Glu Thr Glu 
    1100                 1105                 1110             


Lys Ser  Asp Ser Val Thr Asp  Ser Gly Pro Thr Phe  Asn Tyr Leu 
    1115                 1120                 1125             


Leu Asp  Met Pro Leu Trp Tyr  Leu Thr Lys Glu Lys  Lys Asp Glu 
    1130                 1135                 1140             


Leu Cys  Arg Leu Arg Asn Glu  Lys Glu Gln Glu Leu  Asp Thr Leu 
    1145                 1150                 1155             


Lys Arg  Lys Ser Pro Ser Asp  Leu Trp Lys Glu Asp  Leu Ala Thr 
    1160                 1165                 1170             


Phe Ile  Glu Glu Leu Glu Ala  Val Glu Ala Lys Glu  Lys Gln Asp 
    1175                 1180                 1185             


Glu Gln  Val Gly Leu Pro Gly  Lys Gly Gly Lys Ala  Lys Gly Lys 
    1190                 1195                 1200             


Lys Thr  Gln Met Ala Glu Val  Leu Pro Ser Pro Arg  Gly Gln Arg 
    1205                 1210                 1215             


Val Ile  Pro Arg Ile Thr Ile  Glu Met Lys Ala Glu  Ala Glu Lys 
    1220                 1225                 1230             


Lys Asn  Lys Lys Lys Ile Lys  Asn Glu Asn Thr Glu  Gly Ser Pro 
    1235                 1240                 1245             


Gln Glu  Asp Gly Val Glu Leu  Glu Gly Leu Lys Gln  Arg Leu Glu 
    1250                 1255                 1260             


Lys Lys  Gln Lys Arg Glu Pro  Gly Thr Lys Thr Lys  Lys Gln Thr 
    1265                 1270                 1275             


Thr Leu  Ala Phe Lys Pro Ile  Lys Lys Gly Lys Lys  Arg Asn Pro 
    1280                 1285                 1290             


Trp Ser  Asp Ser Glu Ser Asp  Arg Ser Ser Asp Glu  Ser Asn Phe 
    1295                 1300                 1305             


Asp Val  Pro Pro Arg Glu Thr  Glu Pro Arg Arg Ala  Ala Thr Lys 
    1310                 1315                 1320             


Thr Lys  Phe Thr Met Asp Leu  Asp Ser Asp Glu Asp  Phe Ser Asp 
    1325                 1330                 1335             


Phe Asp  Glu Lys Thr Asp Asp  Glu Asp Phe Val Pro  Ser Asp Ala 
    1340                 1345                 1350             


Ser Pro  Pro Lys Thr Lys Thr  Ser Pro Lys Leu Ser  Asn Lys Glu 
    1355                 1360                 1365             


Leu Lys  Pro Gln Lys Ser Val  Val Ser Asp Leu Glu  Ala Asp Asp 
    1370                 1375                 1380             


Val Lys  Gly Ser Val Pro Leu  Ser Ser Ser Pro Pro  Ala Thr His 
    1385                 1390                 1395             


Phe Pro  Asp Glu Thr Glu Ile  Thr Asn Pro Val Pro  Lys Lys Asn 
    1400                 1405                 1410             


Val Thr  Val Lys Lys Thr Ala  Ala Lys Ser Gln Ser  Ser Thr Ser 
    1415                 1420                 1425             


Thr Thr  Gly Ala Lys Lys Arg  Ala Ala Pro Lys Gly  Thr Lys Arg 
    1430                 1435                 1440             


Asp Pro  Ala Leu Asn Ser Gly  Val Ser Gln Lys Pro  Asp Pro Ala 
    1445                 1450                 1455             


Lys Thr  Lys Asn Arg Arg Lys  Arg Lys Pro Ser Thr  Ser Asp Asp 
    1460                 1465                 1470             


Ser Asp  Ser Asn Phe Glu Lys  Ile Val Ser Lys Ala  Val Thr Ser 
    1475                 1480                 1485             


Lys Lys  Ser Lys Gly Glu Ser  Asp Asp Phe His Met  Asp Phe Asp 
    1490                 1495                 1500             


Ser Ala  Val Ala Pro Arg Ala  Lys Ser Val Arg Ala  Lys Lys Pro 
    1505                 1510                 1515             


Ile Lys  Tyr Leu Glu Glu Ser  Asp Glu Asp Asp Leu  Phe 
    1520                 1525                 1530     


<210>  215
<211>  675
<212>  DNA
<213>  Homo sapiens

<400>  215
atggattgta gagagatgga cttatatgag gactaccagt ccccgtttga ttttgatgca       60

ggagtgaaca aaagctatct ctacttgtct cctagtggaa attcatctcc acccggatca      120

cctactcttc agaaatttgg tctgctgaga acagacccag tccctgagga aggagaagat      180

gttgctgcca cgatcagtgc cacagagacc ctctcggaag aggagcagga agagctaaga      240

agagaacttg caaaggtaga agaagaaatc cagactctgt ctcaagtgtt agcagcaaaa      300

gagaagcatc tagcagagat caagcggaaa cttggaatca attctctaca ggaactaaaa      360

cagaacattg ccaaagggtg gcaagacgtg acagcaacat ctgcttacaa gaagacatct      420

gaaaccttat cccaggctgg acagaaggcc tcagctgctt tttcgtctgt tggctcagtc      480

atcaccaaaa agctggaaga tgtaaaaaac tccccaactt ttaaatcatt tgaagaaaag      540

gtcgaaaact taaagtctaa agtaggggga accaagcctg ctggtggtga ttttggagaa      600

gtcttgaatt cggctgcaaa tgctagtgcc accaccacgg agcctcttcc agaaaagaca      660

caggagagcc tgtga                                                       675


<210>  216
<211>  224
<212>  PRT
<213>  Homo sapiens

<400>  216

Met Asp Cys Arg Glu Met Asp Leu Tyr Glu Asp Tyr Gln Ser Pro Phe 
1               5                   10                  15      


Asp Phe Asp Ala Gly Val Asn Lys Ser Tyr Leu Tyr Leu Ser Pro Ser 
            20                  25                  30          


Gly Asn Ser Ser Pro Pro Gly Ser Pro Thr Leu Gln Lys Phe Gly Leu 
        35                  40                  45              


Leu Arg Thr Asp Pro Val Pro Glu Glu Gly Glu Asp Val Ala Ala Thr 
    50                  55                  60                  


Ile Ser Ala Thr Glu Thr Leu Ser Glu Glu Glu Gln Glu Glu Leu Arg 
65                  70                  75                  80  


Arg Glu Leu Ala Lys Val Glu Glu Glu Ile Gln Thr Leu Ser Gln Val 
                85                  90                  95      


Leu Ala Ala Lys Glu Lys His Leu Ala Glu Ile Lys Arg Lys Leu Gly 
            100                 105                 110         


Ile Asn Ser Leu Gln Glu Leu Lys Gln Asn Ile Ala Lys Gly Trp Gln 
        115                 120                 125             


Asp Val Thr Ala Thr Ser Ala Tyr Lys Lys Thr Ser Glu Thr Leu Ser 
    130                 135                 140                 


Gln Ala Gly Gln Lys Ala Ser Ala Ala Phe Ser Ser Val Gly Ser Val 
145                 150                 155                 160 


Ile Thr Lys Lys Leu Glu Asp Val Lys Asn Ser Pro Thr Phe Lys Ser 
                165                 170                 175     


Phe Glu Glu Lys Val Glu Asn Leu Lys Ser Lys Val Gly Gly Thr Lys 
            180                 185                 190         


Pro Ala Gly Gly Asp Phe Gly Glu Val Leu Asn Ser Ala Ala Asn Ala 
        195                 200                 205             


Ser Ala Thr Thr Thr Glu Pro Leu Pro Glu Lys Thr Gln Glu Ser Leu 
    210                 215                 220                 


<210>  217
<211>  1893
<212>  DNA
<213>  Homo sapiens

<400>  217
atggcagagc tgtgccccct ggccgaggag ctgtcgtgct ccatctgcct ggagcccttc       60

aaggagccgg tcaccactcc gtgcggccac aacttctgcg ggtcgtgcct gaatgagacg      120

tgggcagtcc agggctcgcc atacctgtgc ccgcagtgcc gcgccgtcta ccaggcgcga      180

ccgcagctgc acaagaacac ggtgctgtgc aacgtggtgg agcagttcct gcaggccgac      240

ctggcccggg agccacccgc cgacgtctgg acgccgcccg cccgcgcctc tgcacccagc      300

ccgaatgccc aggtggcctg cgaccactgc ctgaaggagg ccgccgtgaa gacgtgcttg      360

gtgtgcatgg cctccttctg tcaggagcac ctgcagccgc acttcgacag ccccgccttc      420

caggaccacc cgctgcagcc gcccgttcgc gacctgttgc gccgcaaatg ttcccagcac      480

aatcggctgc gggaattttt ctgccccgag cacagcgagt gcatctgcca catctgcctg      540

gtggagcata agacctgctc tcccgcgtcc ctgagccagg ccagcgccga cctggaggcc      600

accctgaggc acaaactaac tgtcatgtac agtcagatca acggggcgtc gagagcactg      660

gatgatgtga gaaacaggca gcaggatgtg cggatgactg caaacagaaa ggtggagcag      720

ctacaacaag aatacacgga aatgaaggct ctcttggacg cctcagagac cacctcgaca      780

aggaagataa aggaagagga gaagagggtc aacagcaagt ttgacaccat ttatcagatt      840

ctcctcaaga agaagagtga gatccagacc ttgaaggagg agattgaaca gagcctgacc      900

aagagggatg agttcgagtt tctggagaaa gcatcaaaac tgcgaggaat ctcaacaaag      960

ccagtctaca tccccgaggt ggaactgaac cacaagctga taaaaggcat ccaccagagc     1020

accatagacc tcaaaaacga gctgaagcag tgcatcgggc ggctccagga gcccaccccc     1080

agttcaggtg accctggaga gcatgaccca gcgtccacac acaaatccac acgccctgtg     1140

aagaaggtct ccaaagagga aaagaaatcc aagaaacctc cccctgtccc tgccttaccc     1200

agcaagcttc ccacgtttgg agccccggaa cagttagtgg atttaaaaca agctggcttg     1260

gaggctgcag ccaaagccac cagctcacat ccgaactcaa catctctcaa ggccaaggtg     1320

ctggagacct tcctggccaa gtccagacct gagctcctgg agtattacat taaagtcatc     1380

ctggactaca acaccgccca caacaaagtg gctctgtcag agtgctatac agtagcttct     1440

gtggctgaga tgcctcagaa ctaccggccg catccccaga ggttcacata ctgctctcag     1500

gtgctgggcc tgcactgcta caagaagggg atccactact gggaggtgga gctgcagaag     1560

aacaacttct gtggggtagg catctgctac ggaagcatga accggcaggg cccagaaagc     1620

aggctcggcc gcaacagcgc ctcctggtgc gtggagtggt tcaacaccaa gatctctgcc     1680

tggcacaata acgtggagaa aaccctgccc tccaccaagg ccacgcgggt gggcgtgctt     1740

ctcaactgtg accacggctt tgtcatcttc ttcgctgttg ccgacaaggt ccacctgatg     1800

tataagttca gggtggactt tactgaggct ttgtacccgg ctttctgggt attttctgct     1860

ggtgccacac tctccatctg ctcccccaag tag                                  1893


<210>  218
<211>  630
<212>  PRT
<213>  Homo sapiens

<400>  218

Met Ala Glu Leu Cys Pro Leu Ala Glu Glu Leu Ser Cys Ser Ile Cys 
1               5                   10                  15      


Leu Glu Pro Phe Lys Glu Pro Val Thr Thr Pro Cys Gly His Asn Phe 
            20                  25                  30          


Cys Gly Ser Cys Leu Asn Glu Thr Trp Ala Val Gln Gly Ser Pro Tyr 
        35                  40                  45              


Leu Cys Pro Gln Cys Arg Ala Val Tyr Gln Ala Arg Pro Gln Leu His 
    50                  55                  60                  


Lys Asn Thr Val Leu Cys Asn Val Val Glu Gln Phe Leu Gln Ala Asp 
65                  70                  75                  80  


Leu Ala Arg Glu Pro Pro Ala Asp Val Trp Thr Pro Pro Ala Arg Ala 
                85                  90                  95      


Ser Ala Pro Ser Pro Asn Ala Gln Val Ala Cys Asp His Cys Leu Lys 
            100                 105                 110         


Glu Ala Ala Val Lys Thr Cys Leu Val Cys Met Ala Ser Phe Cys Gln 
        115                 120                 125             


Glu His Leu Gln Pro His Phe Asp Ser Pro Ala Phe Gln Asp His Pro 
    130                 135                 140                 


Leu Gln Pro Pro Val Arg Asp Leu Leu Arg Arg Lys Cys Ser Gln His 
145                 150                 155                 160 


Asn Arg Leu Arg Glu Phe Phe Cys Pro Glu His Ser Glu Cys Ile Cys 
                165                 170                 175     


His Ile Cys Leu Val Glu His Lys Thr Cys Ser Pro Ala Ser Leu Ser 
            180                 185                 190         


Gln Ala Ser Ala Asp Leu Glu Ala Thr Leu Arg His Lys Leu Thr Val 
        195                 200                 205             


Met Tyr Ser Gln Ile Asn Gly Ala Ser Arg Ala Leu Asp Asp Val Arg 
    210                 215                 220                 


Asn Arg Gln Gln Asp Val Arg Met Thr Ala Asn Arg Lys Val Glu Gln 
225                 230                 235                 240 


Leu Gln Gln Glu Tyr Thr Glu Met Lys Ala Leu Leu Asp Ala Ser Glu 
                245                 250                 255     


Thr Thr Ser Thr Arg Lys Ile Lys Glu Glu Glu Lys Arg Val Asn Ser 
            260                 265                 270         


Lys Phe Asp Thr Ile Tyr Gln Ile Leu Leu Lys Lys Lys Ser Glu Ile 
        275                 280                 285             


Gln Thr Leu Lys Glu Glu Ile Glu Gln Ser Leu Thr Lys Arg Asp Glu 
    290                 295                 300                 


Phe Glu Phe Leu Glu Lys Ala Ser Lys Leu Arg Gly Ile Ser Thr Lys 
305                 310                 315                 320 


Pro Val Tyr Ile Pro Glu Val Glu Leu Asn His Lys Leu Ile Lys Gly 
                325                 330                 335     


Ile His Gln Ser Thr Ile Asp Leu Lys Asn Glu Leu Lys Gln Cys Ile 
            340                 345                 350         


Gly Arg Leu Gln Glu Pro Thr Pro Ser Ser Gly Asp Pro Gly Glu His 
        355                 360                 365             


Asp Pro Ala Ser Thr His Lys Ser Thr Arg Pro Val Lys Lys Val Ser 
    370                 375                 380                 


Lys Glu Glu Lys Lys Ser Lys Lys Pro Pro Pro Val Pro Ala Leu Pro 
385                 390                 395                 400 


Ser Lys Leu Pro Thr Phe Gly Ala Pro Glu Gln Leu Val Asp Leu Lys 
                405                 410                 415     


Gln Ala Gly Leu Glu Ala Ala Ala Lys Ala Thr Ser Ser His Pro Asn 
            420                 425                 430         


Ser Thr Ser Leu Lys Ala Lys Val Leu Glu Thr Phe Leu Ala Lys Ser 
        435                 440                 445             


Arg Pro Glu Leu Leu Glu Tyr Tyr Ile Lys Val Ile Leu Asp Tyr Asn 
    450                 455                 460                 


Thr Ala His Asn Lys Val Ala Leu Ser Glu Cys Tyr Thr Val Ala Ser 
465                 470                 475                 480 


Val Ala Glu Met Pro Gln Asn Tyr Arg Pro His Pro Gln Arg Phe Thr 
                485                 490                 495     


Tyr Cys Ser Gln Val Leu Gly Leu His Cys Tyr Lys Lys Gly Ile His 
            500                 505                 510         


Tyr Trp Glu Val Glu Leu Gln Lys Asn Asn Phe Cys Gly Val Gly Ile 
        515                 520                 525             


Cys Tyr Gly Ser Met Asn Arg Gln Gly Pro Glu Ser Arg Leu Gly Arg 
    530                 535                 540                 


Asn Ser Ala Ser Trp Cys Val Glu Trp Phe Asn Thr Lys Ile Ser Ala 
545                 550                 555                 560 


Trp His Asn Asn Val Glu Lys Thr Leu Pro Ser Thr Lys Ala Thr Arg 
                565                 570                 575     


Val Gly Val Leu Leu Asn Cys Asp His Gly Phe Val Ile Phe Phe Ala 
            580                 585                 590         


Val Ala Asp Lys Val His Leu Met Tyr Lys Phe Arg Val Asp Phe Thr 
        595                 600                 605             


Glu Ala Leu Tyr Pro Ala Phe Trp Val Phe Ser Ala Gly Ala Thr Leu 
    610                 615                 620                 


Ser Ile Cys Ser Pro Lys 
625                 630 


<210>  219
<211>  2508
<212>  DNA
<213>  Homo sapiens

<400>  219
atggcggcct ccgcggcggc agcctcggca gcagcggcct cggccgcctc tggcagcccg       60

ggcccgggcg agggctccgc tggcggcgaa aagcgctcca ccgccccttc ggccgcagcc      120

tcggcctctg cctcagccgc ggcgtcgtcg cccgcggggg gcggcgccga ggcgctggag      180

ctgctggagc actgcggcgt gtgcagagag cgcctgcgac ccgagaggga gccccgcctg      240

ctgccctgtt tgcactcggc ctgtagtgcc tgcttagggc ccgcggcccc cgccgccgcc      300

aacagctcgg gggacggcgg ggcggcgggc gacggcaccg tggtggactg tcccgtgtgc      360

aagcaacagt gcttctccaa agacatcgtg gagaattatt tcatgcgtga tagtggcagc      420

aaggctgcca ccgacgccca ggatgcgaac cagtgctgca ctagctgtga ggataatgcc      480

ccagccacca gctactgtgt ggagtgctcg gagcctctgt gtgagacctg tgtagaggcg      540

caccagcggg tgaagtacac caaggaccat actgtgcgct ctactgggcc agccaagtct      600

cgggatggtg aacgtactgt ctattgcaac gtacacaagc atgaacccct tgtgctgttt      660

tgtgagagct gtgatactct cacctgccga gactgccagc tcaatgccca caaggaccac      720

cagtaccagt tcttagagga tgcagtgagg aaccagcgca agctcctggc ctcactggtg      780

aagcgccttg gggacaaaca tgcaacattg cagaagagca ccaaggaggt tcgcagctca      840

atccgccagg tgtctgacgt acagaagcgt gtgcaagtgg atgtcaagat ggccatcctg      900

cagatcatga aggagctgaa taagcggggc cgtgtgctgg tcaatgatgc ccagaaggtg      960

actgaggggc agcaggagcg cctggagcgg cagcactgga ccatgaccaa gatccagaag     1020

caccaggagc acattctgcg ctttgcctct tgggctctgg agagtgacaa caacacagcc     1080

cttttgcttt ctaagaagtt gatctacttc cagctgcacc gggccctcaa gatgattgtg     1140

gatcccgtgg agccacatgg cgagatgaag tttcagtggg acctcaatgc ctggaccaag     1200

agtgccgagg cctttggcaa gattgtggca gagcgtcctg gcactaactc aacaggccct     1260

gcacccatgg cccctccaag agccccaggg cccctgagca agcagggctc tggcagcagc     1320

cagcccatgg aggtgcagga aggctatggc tttgggtcag gagatgatcc ctactcaagt     1380

gcagagcccc atgtgtcagg tgtgaaacgg tcccgctcag gtgagggcga ggtgagcggc     1440

cttatgcgca aggtgccacg agtgagcctt gaacgcctgg acctggacct cacagctgac     1500

agccagccac ccgtcttcaa ggtcttccca ggcagtacca ctgaggacta caaccttatt     1560

gttattgaac gtggcgctgc cgctgcagct accggccagc cagggactgc gcctgcagga     1620

acccctggtg ccccacccct ggctggcatg gccattgtca aggaggagga gacggaggct     1680

gccattggag cccctcctac tgccactgag ggccctgaga ccaaacctgt gcttatggct     1740

cttgcggagg gtcctggtgc tgagggtccc cgcctggcct cacctagtgg cagcaccagc     1800

tcagggctgg aggtggtggc tcctgagggt acctcagccc caggtggtgg cccgggaacc     1860

ctggatgaca gtgccaccat ttgccgtgtc tgccagaagc caggcgatct ggttatgtgc     1920

aaccagtgtg agttttgttt ccacctggac tgtcacctgc cggccctgca ggatgtacca     1980

ggggaggagt ggagctgctc actctgccat gtgctccctg acctgaagga ggaggatggc     2040

agcctcagcc tggatggtgc agacagcact ggcgtggtgg ccaagctctc accagccaac     2100

cagcggaaat gtgagcgtgt actgctggcc ctattctgtc acgaaccctg ccgccccctg     2160

catcagctgg ctaccgactc caccttctcc ctggaccagc ccggtggcac cctggatctg     2220

accctgatcc gtgcccgcct ccaggagaag ttgtcacctc cctacagctc cccacaggag     2280

tttgcccagg atgtgggccg catgttcaag caattcaaca agttaactga ggacaaggca     2340

gacgtgcagt ccatcatcgg cctgcagcgc ttcttcgaga cgcgcatgaa cgaggccttc     2400

ggtgacacca agttctctgc tgtgctggtg gagcccccgc cgatgagcct gcctggtgct     2460

ggcctgagtt cccaggagct gtctggtggc cctggtgatg gcccctga                  2508


<210>  220
<211>  835
<212>  PRT
<213>  Homo sapiens

<400>  220

Met Ala Ala Ser Ala Ala Ala Ala Ser Ala Ala Ala Ala Ser Ala Ala 
1               5                   10                  15      


Ser Gly Ser Pro Gly Pro Gly Glu Gly Ser Ala Gly Gly Glu Lys Arg 
            20                  25                  30          


Ser Thr Ala Pro Ser Ala Ala Ala Ser Ala Ser Ala Ser Ala Ala Ala 
        35                  40                  45              


Ser Ser Pro Ala Gly Gly Gly Ala Glu Ala Leu Glu Leu Leu Glu His 
    50                  55                  60                  


Cys Gly Val Cys Arg Glu Arg Leu Arg Pro Glu Arg Glu Pro Arg Leu 
65                  70                  75                  80  


Leu Pro Cys Leu His Ser Ala Cys Ser Ala Cys Leu Gly Pro Ala Ala 
                85                  90                  95      


Pro Ala Ala Ala Asn Ser Ser Gly Asp Gly Gly Ala Ala Gly Asp Gly 
            100                 105                 110         


Thr Val Val Asp Cys Pro Val Cys Lys Gln Gln Cys Phe Ser Lys Asp 
        115                 120                 125             


Ile Val Glu Asn Tyr Phe Met Arg Asp Ser Gly Ser Lys Ala Ala Thr 
    130                 135                 140                 


Asp Ala Gln Asp Ala Asn Gln Cys Cys Thr Ser Cys Glu Asp Asn Ala 
145                 150                 155                 160 


Pro Ala Thr Ser Tyr Cys Val Glu Cys Ser Glu Pro Leu Cys Glu Thr 
                165                 170                 175     


Cys Val Glu Ala His Gln Arg Val Lys Tyr Thr Lys Asp His Thr Val 
            180                 185                 190         


Arg Ser Thr Gly Pro Ala Lys Ser Arg Asp Gly Glu Arg Thr Val Tyr 
        195                 200                 205             


Cys Asn Val His Lys His Glu Pro Leu Val Leu Phe Cys Glu Ser Cys 
    210                 215                 220                 


Asp Thr Leu Thr Cys Arg Asp Cys Gln Leu Asn Ala His Lys Asp His 
225                 230                 235                 240 


Gln Tyr Gln Phe Leu Glu Asp Ala Val Arg Asn Gln Arg Lys Leu Leu 
                245                 250                 255     


Ala Ser Leu Val Lys Arg Leu Gly Asp Lys His Ala Thr Leu Gln Lys 
            260                 265                 270         


Ser Thr Lys Glu Val Arg Ser Ser Ile Arg Gln Val Ser Asp Val Gln 
        275                 280                 285             


Lys Arg Val Gln Val Asp Val Lys Met Ala Ile Leu Gln Ile Met Lys 
    290                 295                 300                 


Glu Leu Asn Lys Arg Gly Arg Val Leu Val Asn Asp Ala Gln Lys Val 
305                 310                 315                 320 


Thr Glu Gly Gln Gln Glu Arg Leu Glu Arg Gln His Trp Thr Met Thr 
                325                 330                 335     


Lys Ile Gln Lys His Gln Glu His Ile Leu Arg Phe Ala Ser Trp Ala 
            340                 345                 350         


Leu Glu Ser Asp Asn Asn Thr Ala Leu Leu Leu Ser Lys Lys Leu Ile 
        355                 360                 365             


Tyr Phe Gln Leu His Arg Ala Leu Lys Met Ile Val Asp Pro Val Glu 
    370                 375                 380                 


Pro His Gly Glu Met Lys Phe Gln Trp Asp Leu Asn Ala Trp Thr Lys 
385                 390                 395                 400 


Ser Ala Glu Ala Phe Gly Lys Ile Val Ala Glu Arg Pro Gly Thr Asn 
                405                 410                 415     


Ser Thr Gly Pro Ala Pro Met Ala Pro Pro Arg Ala Pro Gly Pro Leu 
            420                 425                 430         


Ser Lys Gln Gly Ser Gly Ser Ser Gln Pro Met Glu Val Gln Glu Gly 
        435                 440                 445             


Tyr Gly Phe Gly Ser Gly Asp Asp Pro Tyr Ser Ser Ala Glu Pro His 
    450                 455                 460                 


Val Ser Gly Val Lys Arg Ser Arg Ser Gly Glu Gly Glu Val Ser Gly 
465                 470                 475                 480 


Leu Met Arg Lys Val Pro Arg Val Ser Leu Glu Arg Leu Asp Leu Asp 
                485                 490                 495     


Leu Thr Ala Asp Ser Gln Pro Pro Val Phe Lys Val Phe Pro Gly Ser 
            500                 505                 510         


Thr Thr Glu Asp Tyr Asn Leu Ile Val Ile Glu Arg Gly Ala Ala Ala 
        515                 520                 525             


Ala Ala Thr Gly Gln Pro Gly Thr Ala Pro Ala Gly Thr Pro Gly Ala 
    530                 535                 540                 


Pro Pro Leu Ala Gly Met Ala Ile Val Lys Glu Glu Glu Thr Glu Ala 
545                 550                 555                 560 


Ala Ile Gly Ala Pro Pro Thr Ala Thr Glu Gly Pro Glu Thr Lys Pro 
                565                 570                 575     


Val Leu Met Ala Leu Ala Glu Gly Pro Gly Ala Glu Gly Pro Arg Leu 
            580                 585                 590         


Ala Ser Pro Ser Gly Ser Thr Ser Ser Gly Leu Glu Val Val Ala Pro 
        595                 600                 605             


Glu Gly Thr Ser Ala Pro Gly Gly Gly Pro Gly Thr Leu Asp Asp Ser 
    610                 615                 620                 


Ala Thr Ile Cys Arg Val Cys Gln Lys Pro Gly Asp Leu Val Met Cys 
625                 630                 635                 640 


Asn Gln Cys Glu Phe Cys Phe His Leu Asp Cys His Leu Pro Ala Leu 
                645                 650                 655     


Gln Asp Val Pro Gly Glu Glu Trp Ser Cys Ser Leu Cys His Val Leu 
            660                 665                 670         


Pro Asp Leu Lys Glu Glu Asp Gly Ser Leu Ser Leu Asp Gly Ala Asp 
        675                 680                 685             


Ser Thr Gly Val Val Ala Lys Leu Ser Pro Ala Asn Gln Arg Lys Cys 
    690                 695                 700                 


Glu Arg Val Leu Leu Ala Leu Phe Cys His Glu Pro Cys Arg Pro Leu 
705                 710                 715                 720 


His Gln Leu Ala Thr Asp Ser Thr Phe Ser Leu Asp Gln Pro Gly Gly 
                725                 730                 735     


Thr Leu Asp Leu Thr Leu Ile Arg Ala Arg Leu Gln Glu Lys Leu Ser 
            740                 745                 750         


Pro Pro Tyr Ser Ser Pro Gln Glu Phe Ala Gln Asp Val Gly Arg Met 
        755                 760                 765             


Phe Lys Gln Phe Asn Lys Leu Thr Glu Asp Lys Ala Asp Val Gln Ser 
    770                 775                 780                 


Ile Ile Gly Leu Gln Arg Phe Phe Glu Thr Arg Met Asn Glu Ala Phe 
785                 790                 795                 800 


Gly Asp Thr Lys Phe Ser Ala Val Leu Val Glu Pro Pro Pro Met Ser 
                805                 810                 815     


Leu Pro Gly Ala Gly Leu Ser Ser Gln Glu Leu Ser Gly Gly Pro Gly 
            820                 825                 830         


Asp Gly Pro 
        835 


<210>  221
<211>  3564
<212>  DNA
<213>  Homo sapiens

<400>  221
atgcctctgc gccactgggg gatggccagg ggcagtaagc ccgttgggga tggagcccag       60

cccatggctg ccatgggagg cctgaaggtg cttctgcact gggctggtcc aggcggcggg      120

gagccctggg tcactttcag tgagtcatcg ctgacagctg aggaagtctg catccacatt      180

gcacataaag ttggtatcac tcctccttgc ttcaatctct ttgccctctt cgatgctcag      240

gcccaagtct ggttgccccc aaaccacatc ctagagatcc ccagagatgc aagcctgatg      300

ctatatttcc gcataaggtt ttatttccgg aactggcatg gcatgaatcc tcgggaaccg      360

gctgtgtacc gttgtgggcc cccaggaacc gaggcatcct cagatcagac agcacagggg      420

atgcaactcc tggacccagc ctcatttgag tacctctttg agcagggcaa gcatgagttt      480

gtgaatgacg tggcatcact gtgggagctg tcgaccgagg aggagatcca ccactttaag      540

aatgagagcc tgggcatggc ctttctgcac ctctgtcacc tcgctctccg ccatggcatc      600

cccctggagg aggtggccaa gaagaccagc ttcaaggact gcatcccgcg ctccttccgc      660

cggcatatcc ggcagcacag cgccctgacc cggctgcgcc ttcggaacgt cttccgcagg      720

ttcctgcggg acttccagcc gggccgactc tcccagcaga tggtcatggt caaataccta      780

gccacactcg agcggctggc accccgcttc ggcacagagc gtgtgcccgt gtgccacctg      840

aggctgctgg cccaggccga gggggagccc tgctacatcc gggacagtgg ggtggcccct      900

acagaccctg gccctgagtc tgctgctggg cccccaaccc acgaggtgct ggtgacaggc      960

actggtggca tccagtggtg gccagtagag gaggaggtga acaaggagga gggttctagt     1020

ggcagcagtg gcaggaaccc ccaagccagc ctgtttggga agaaggccaa ggctcacaag     1080

gcagtcggcc agccggcaga caggccgcgg gagccactgt gggcctactt ctgtgacttc     1140

cgggacatca cccacgtggt gctgaaagag cactgtgtca gcatccaccg gcaggacaac     1200

aagtgcctgg agctgagctt gccttcccgg gctgcggcgc tgtccttcgt gtcgctggtg     1260

gacggctatt tccgcctgac ggccgactcc agccactacc tgtgccacga ggtggctccc     1320

ccacggctgg tgatgagcat ccgggatggg atccacggac ccctgctgga gccatttgtg     1380

caggccaagc tgcggcccga ggacggcctg tacctcattc actggagcac cagccacccc     1440

taccgcctga tcctcacagt ggcccagcgt agccaggcac cagacggcat gcagagcttg     1500

cggctccgaa agttccccat tgagcagcag gacggggcct tcgtgctgga gggctggggc     1560

cggtccttcc ccagcgttcg ggaacttggg gctgccttgc agggctgctt gctgagggcc     1620

ggggatgact gcttctctct gcgtcgctgt tgcctgcccc aaccaggaga aacctccaat     1680

ctcatcatca tgcggggggc tcgggccagc cccaggacac tcaacctcag ccagctcagc     1740

ttccaccggg ttgaccagaa ggagatcacc cagctgtccc acttgggcca gggcacaagg     1800

accaacgtgt atgagggccg cctgcgagtg gagggcagcg gggaccctga ggagggcaag     1860

atggatgacg aggaccccct cgtgcctggc agggaccgtg ggcaggagct acgagtggtg     1920

ctcaaagtgc tggaccctag tcaccatgac atcgccctgg ccttctacga gacagccagc     1980

ctcatgagcc aggtctccca cacgcacctg gccttcgtgc atggcgtctg tgtgcgcggc     2040

cctgaaaata tcatggtgac agagtacgtg gagcacggac ccctggatgt gtggctgcgg     2100

agggagcggg gccatgtgcc catggcttgg aagatggtgg tggcccagca gctggccagc     2160

gccctcagct acctggagaa caagaacctg gttcatggta atgtgtgtgg ccggaacatc     2220

ctgctggccc ggctggggtt ggcagagggc accagcccct tcatcaagct gagtgatcct     2280

ggcgtgggcc tgggcgccct ctccagggag gagcgggtgg agaggatccc ctggctggcc     2340

cccgaatgcc taccaggtgg ggccaacagc ctaagcaccg ccatggacaa gtgggggttt     2400

ggcgccaccc tcctggagat ctgctttgac ggagaggccc ctctgcagag ccgcagtccc     2460

tccgagaagg agcatttcta ccagaggcag caccggctgc ccgagccctc ctgcccacag     2520

ctggccacac tcaccagcca gtgtctgacc tatgagccaa cccagaggcc atcattccgc     2580

accatcctgc gtgacctcac ccggctgcag ccccacaatc ttgctgacgt cttgactgtg     2640

aacccggact caccggcgtc ggaccctacg gttttccaca agcgctattt gaaaaagatc     2700

cgagatctgg gcgagggtca cttcggcaag gtcagcttgt actgctacga tccgaccaac     2760

gacggcactg gcgagatggt ggcggtgaaa gccctcaagg cagactgcgg cccccagcac     2820

cgctcgggct ggaagcagga gattgacatt ctgcgcacgc tctaccacga gcacatcatc     2880

aagtacaagg gctgctgcga ggaccaaggc gagaagtcgc tgcagctggt catggagtac     2940

gtgcccctgg gcagcctccg agactacctg ccccggcaca gcatcgggct ggcccagctg     3000

ctgctcttcg cccagcagat ctgcgagggc atggcctatc tgcacgcgca gcactacatc     3060

caccgagacc tagccgcgcg caacgtgctg ctggacaacg acaggctggt caagatcggg     3120

gactttggcc tagccaaggc cgtgcccgaa ggccacgagt actaccgcgt gcgcgaggat     3180

ggggacagcc ccgtgttctg gtatgcccca gagtgcctga aggagtataa gttctactat     3240

gcgtcagatg tctggtcctt cggggtgacc ctgtatgagc tgctgacgca ctgtgactcc     3300

agccagagcc cccccacgaa attccttgag ctcataggca ttgctcaggg tcagatgaca     3360

gttctgagac tcactgagtt gctggaacga ggggagaggc tgccacggcc cgacaaatgt     3420

ccctgtgagg tctatcatct catgaagaac tgctgggaga cagaggcgtc ctttcgccca     3480

accttcgaga acctcatacc cattctgaag acagtccatg agaagtacca aggccaggcc     3540

ccttcagtgt tcagcgtgtg ctga                                            3564


<210>  222
<211>  1187
<212>  PRT
<213>  Homo sapiens

<400>  222

Met Pro Leu Arg His Trp Gly Met Ala Arg Gly Ser Lys Pro Val Gly 
1               5                   10                  15      


Asp Gly Ala Gln Pro Met Ala Ala Met Gly Gly Leu Lys Val Leu Leu 
            20                  25                  30          


His Trp Ala Gly Pro Gly Gly Gly Glu Pro Trp Val Thr Phe Ser Glu 
        35                  40                  45              


Ser Ser Leu Thr Ala Glu Glu Val Cys Ile His Ile Ala His Lys Val 
    50                  55                  60                  


Gly Ile Thr Pro Pro Cys Phe Asn Leu Phe Ala Leu Phe Asp Ala Gln 
65                  70                  75                  80  


Ala Gln Val Trp Leu Pro Pro Asn His Ile Leu Glu Ile Pro Arg Asp 
                85                  90                  95      


Ala Ser Leu Met Leu Tyr Phe Arg Ile Arg Phe Tyr Phe Arg Asn Trp 
            100                 105                 110         


His Gly Met Asn Pro Arg Glu Pro Ala Val Tyr Arg Cys Gly Pro Pro 
        115                 120                 125             


Gly Thr Glu Ala Ser Ser Asp Gln Thr Ala Gln Gly Met Gln Leu Leu 
    130                 135                 140                 


Asp Pro Ala Ser Phe Glu Tyr Leu Phe Glu Gln Gly Lys His Glu Phe 
145                 150                 155                 160 


Val Asn Asp Val Ala Ser Leu Trp Glu Leu Ser Thr Glu Glu Glu Ile 
                165                 170                 175     


His His Phe Lys Asn Glu Ser Leu Gly Met Ala Phe Leu His Leu Cys 
            180                 185                 190         


His Leu Ala Leu Arg His Gly Ile Pro Leu Glu Glu Val Ala Lys Lys 
        195                 200                 205             


Thr Ser Phe Lys Asp Cys Ile Pro Arg Ser Phe Arg Arg His Ile Arg 
    210                 215                 220                 


Gln His Ser Ala Leu Thr Arg Leu Arg Leu Arg Asn Val Phe Arg Arg 
225                 230                 235                 240 


Phe Leu Arg Asp Phe Gln Pro Gly Arg Leu Ser Gln Gln Met Val Met 
                245                 250                 255     


Val Lys Tyr Leu Ala Thr Leu Glu Arg Leu Ala Pro Arg Phe Gly Thr 
            260                 265                 270         


Glu Arg Val Pro Val Cys His Leu Arg Leu Leu Ala Gln Ala Glu Gly 
        275                 280                 285             


Glu Pro Cys Tyr Ile Arg Asp Ser Gly Val Ala Pro Thr Asp Pro Gly 
    290                 295                 300                 


Pro Glu Ser Ala Ala Gly Pro Pro Thr His Glu Val Leu Val Thr Gly 
305                 310                 315                 320 


Thr Gly Gly Ile Gln Trp Trp Pro Val Glu Glu Glu Val Asn Lys Glu 
                325                 330                 335     


Glu Gly Ser Ser Gly Ser Ser Gly Arg Asn Pro Gln Ala Ser Leu Phe 
            340                 345                 350         


Gly Lys Lys Ala Lys Ala His Lys Ala Val Gly Gln Pro Ala Asp Arg 
        355                 360                 365             


Pro Arg Glu Pro Leu Trp Ala Tyr Phe Cys Asp Phe Arg Asp Ile Thr 
    370                 375                 380                 


His Val Val Leu Lys Glu His Cys Val Ser Ile His Arg Gln Asp Asn 
385                 390                 395                 400 


Lys Cys Leu Glu Leu Ser Leu Pro Ser Arg Ala Ala Ala Leu Ser Phe 
                405                 410                 415     


Val Ser Leu Val Asp Gly Tyr Phe Arg Leu Thr Ala Asp Ser Ser His 
            420                 425                 430         


Tyr Leu Cys His Glu Val Ala Pro Pro Arg Leu Val Met Ser Ile Arg 
        435                 440                 445             


Asp Gly Ile His Gly Pro Leu Leu Glu Pro Phe Val Gln Ala Lys Leu 
    450                 455                 460                 


Arg Pro Glu Asp Gly Leu Tyr Leu Ile His Trp Ser Thr Ser His Pro 
465                 470                 475                 480 


Tyr Arg Leu Ile Leu Thr Val Ala Gln Arg Ser Gln Ala Pro Asp Gly 
                485                 490                 495     


Met Gln Ser Leu Arg Leu Arg Lys Phe Pro Ile Glu Gln Gln Asp Gly 
            500                 505                 510         


Ala Phe Val Leu Glu Gly Trp Gly Arg Ser Phe Pro Ser Val Arg Glu 
        515                 520                 525             


Leu Gly Ala Ala Leu Gln Gly Cys Leu Leu Arg Ala Gly Asp Asp Cys 
    530                 535                 540                 


Phe Ser Leu Arg Arg Cys Cys Leu Pro Gln Pro Gly Glu Thr Ser Asn 
545                 550                 555                 560 


Leu Ile Ile Met Arg Gly Ala Arg Ala Ser Pro Arg Thr Leu Asn Leu 
                565                 570                 575     


Ser Gln Leu Ser Phe His Arg Val Asp Gln Lys Glu Ile Thr Gln Leu 
            580                 585                 590         


Ser His Leu Gly Gln Gly Thr Arg Thr Asn Val Tyr Glu Gly Arg Leu 
        595                 600                 605             


Arg Val Glu Gly Ser Gly Asp Pro Glu Glu Gly Lys Met Asp Asp Glu 
    610                 615                 620                 


Asp Pro Leu Val Pro Gly Arg Asp Arg Gly Gln Glu Leu Arg Val Val 
625                 630                 635                 640 


Leu Lys Val Leu Asp Pro Ser His His Asp Ile Ala Leu Ala Phe Tyr 
                645                 650                 655     


Glu Thr Ala Ser Leu Met Ser Gln Val Ser His Thr His Leu Ala Phe 
            660                 665                 670         


Val His Gly Val Cys Val Arg Gly Pro Glu Asn Ile Met Val Thr Glu 
        675                 680                 685             


Tyr Val Glu His Gly Pro Leu Asp Val Trp Leu Arg Arg Glu Arg Gly 
    690                 695                 700                 


His Val Pro Met Ala Trp Lys Met Val Val Ala Gln Gln Leu Ala Ser 
705                 710                 715                 720 


Ala Leu Ser Tyr Leu Glu Asn Lys Asn Leu Val His Gly Asn Val Cys 
                725                 730                 735     


Gly Arg Asn Ile Leu Leu Ala Arg Leu Gly Leu Ala Glu Gly Thr Ser 
            740                 745                 750         


Pro Phe Ile Lys Leu Ser Asp Pro Gly Val Gly Leu Gly Ala Leu Ser 
        755                 760                 765             


Arg Glu Glu Arg Val Glu Arg Ile Pro Trp Leu Ala Pro Glu Cys Leu 
    770                 775                 780                 


Pro Gly Gly Ala Asn Ser Leu Ser Thr Ala Met Asp Lys Trp Gly Phe 
785                 790                 795                 800 


Gly Ala Thr Leu Leu Glu Ile Cys Phe Asp Gly Glu Ala Pro Leu Gln 
                805                 810                 815     


Ser Arg Ser Pro Ser Glu Lys Glu His Phe Tyr Gln Arg Gln His Arg 
            820                 825                 830         


Leu Pro Glu Pro Ser Cys Pro Gln Leu Ala Thr Leu Thr Ser Gln Cys 
        835                 840                 845             


Leu Thr Tyr Glu Pro Thr Gln Arg Pro Ser Phe Arg Thr Ile Leu Arg 
    850                 855                 860                 


Asp Leu Thr Arg Leu Gln Pro His Asn Leu Ala Asp Val Leu Thr Val 
865                 870                 875                 880 


Asn Pro Asp Ser Pro Ala Ser Asp Pro Thr Val Phe His Lys Arg Tyr 
                885                 890                 895     


Leu Lys Lys Ile Arg Asp Leu Gly Glu Gly His Phe Gly Lys Val Ser 
            900                 905                 910         


Leu Tyr Cys Tyr Asp Pro Thr Asn Asp Gly Thr Gly Glu Met Val Ala 
        915                 920                 925             


Val Lys Ala Leu Lys Ala Asp Cys Gly Pro Gln His Arg Ser Gly Trp 
    930                 935                 940                 


Lys Gln Glu Ile Asp Ile Leu Arg Thr Leu Tyr His Glu His Ile Ile 
945                 950                 955                 960 


Lys Tyr Lys Gly Cys Cys Glu Asp Gln Gly Glu Lys Ser Leu Gln Leu 
                965                 970                 975     


Val Met Glu Tyr Val Pro Leu Gly Ser Leu Arg Asp Tyr Leu Pro Arg 
            980                 985                 990         


His Ser Ile Gly Leu Ala Gln Leu  Leu Leu Phe Ala Gln  Gln Ile Cys 
        995                 1000                 1005             


Glu Gly  Met Ala Tyr Leu His  Ala Gln His Tyr Ile  His Arg Asp 
    1010                 1015                 1020             


Leu Ala  Ala Arg Asn Val Leu  Leu Asp Asn Asp Arg  Leu Val Lys 
    1025                 1030                 1035             


Ile Gly  Asp Phe Gly Leu Ala  Lys Ala Val Pro Glu  Gly His Glu 
    1040                 1045                 1050             


Tyr Tyr  Arg Val Arg Glu Asp  Gly Asp Ser Pro Val  Phe Trp Tyr 
    1055                 1060                 1065             


Ala Pro  Glu Cys Leu Lys Glu  Tyr Lys Phe Tyr Tyr  Ala Ser Asp 
    1070                 1075                 1080             


Val Trp  Ser Phe Gly Val Thr  Leu Tyr Glu Leu Leu  Thr His Cys 
    1085                 1090                 1095             


Asp Ser  Ser Gln Ser Pro Pro  Thr Lys Phe Leu Glu  Leu Ile Gly 
    1100                 1105                 1110             


Ile Ala  Gln Gly Gln Met Thr  Val Leu Arg Leu Thr  Glu Leu Leu 
    1115                 1120                 1125             


Glu Arg  Gly Glu Arg Leu Pro  Arg Pro Asp Lys Cys  Pro Cys Glu 
    1130                 1135                 1140             


Val Tyr  His Leu Met Lys Asn  Cys Trp Glu Thr Glu  Ala Ser Phe 
    1145                 1150                 1155             


Arg Pro  Thr Phe Glu Asn Leu  Ile Pro Ile Leu Lys  Thr Val His 
    1160                 1165                 1170             


Glu Lys  Tyr Gln Gly Gln Ala  Pro Ser Val Phe Ser  Val Cys 
    1175                 1180                 1185         


<210>  223
<211>  1923
<212>  DNA
<213>  Homo sapiens

<400>  223
atggcactgt cgcgggggct gccccgggag ctggctgagg cggtggccgg gggccgggtg       60

ctggtggtgg gggcgggcgg catcggctgc gagctcctca agaatctcgt gctcaccggt      120

ttctcccaca tcgacctgat tgatctggat actattgatg taagcaacct caacagacag      180

tttttgtttc aaaagaaaca tgttggaaga tcaaaggcac aggttgccaa ggaaagtgta      240

ctgcagtttt acccgaaagc taatatcgtt gcctaccatg acagcatcat gaaccctgac      300

tataatgtgg aatttttccg acagtttata ctggttatga atgctttaga taacagagct      360

gcccgaaacc atgttaatag aatgtgcctg gcagctgatg ttcctcttat tgaaagtgga      420

acagctgggt atcttggaca agtaactact atcaaaaagg gtgtgaccga gtgttatgag      480

tgtcatccta agccgaccca gagaaccttt cctggctgta caattcgtaa cacaccttca      540

gaacctatac attgcatcgt ttgggcaaag tacttgttca accagttgtt tggggaagaa      600

gatgctgatc aagaagtatc tcctgacaga gctgaccctg aagctgcctg ggaaccaacg      660

gaagccgaag ccagagctag agcatctaat gaagatggtg acattaaacg tatttctact      720

aaggaatggg ctaaatcaac tggatatgat ccagttaaac tttttaccaa gctttttaaa      780

gatgacatca ggtatctgtt gacaatggac aaactatggc ggaaaaggaa acctccagtt      840

ccgttggact gggctgaagt acaaagtcaa ggagaagaaa cgaatgcatc agatcaacag      900

aatgaacccc agttaggcct gaaagaccag caggttctag atgtaaagag ctatgcacgt      960

cttttttcaa agagcatcga gactttgaga gttcatttag cagaaaaggg ggatggagct     1020

gagctcatat gggataagga tgacccatct gcaatggatt ttgtcacctc tgctgcaaac     1080

ctcaggatgc atattttcag tatgaatatg aagagtagat ttgatatcaa atcaatggca     1140

gggaacatta ttcctgctat tgctactact aatgcagtaa ttgctgggtt gatagtattg     1200

gaaggattga agattttatc aggaaaaata gaccagtgca gaacaatttt tttgaataaa     1260

caaccaaacc caagaaagaa gcttcttgtg ccttgtgcac tggatcctcc caaccccaat     1320

tgttatgtat gtgccagcaa gccagaggtg actgtgcggc tgaatgtcca taaagtgact     1380

gttctcacct tacaagacaa gatagtgaaa gaaaaatttg ctatggtagc accagatgtc     1440

caaattgaag atgggaaagg aacaatccta atatcttccg aagagggaga gacggaagct     1500

aataatcaca agaagttgtc agaatttgga attagaaatg gcagccggct tcaagcagat     1560

gacttcctcc aggactatac tttattgatc aacatccttc atagtgaaga cctaggaaag     1620

gacgttgaat ttgaagttgt tggtgatgcc ccggaaaaag tggggcccaa acaagctgaa     1680

gatgctgcca aaagcataac caatggcagt gatgatggag ctcagccctc cacctccaca     1740

gctcaagagc aagatgacgt tctcatagtt gattcagatg aagaagattc ttcaaataat     1800

gccgacgtca gtgaagaaga gagaagccgc aagaggaaat tagatgagaa agagaatctc     1860

agtgcaaaga ggtcacgtat agaacagaag gaagagcttg atgatgtcat agcattagat     1920

tga                                                                   1923


<210>  224
<211>  640
<212>  PRT
<213>  Homo sapiens

<400>  224

Met Ala Leu Ser Arg Gly Leu Pro Arg Glu Leu Ala Glu Ala Val Ala 
1               5                   10                  15      


Gly Gly Arg Val Leu Val Val Gly Ala Gly Gly Ile Gly Cys Glu Leu 
            20                  25                  30          


Leu Lys Asn Leu Val Leu Thr Gly Phe Ser His Ile Asp Leu Ile Asp 
        35                  40                  45              


Leu Asp Thr Ile Asp Val Ser Asn Leu Asn Arg Gln Phe Leu Phe Gln 
    50                  55                  60                  


Lys Lys His Val Gly Arg Ser Lys Ala Gln Val Ala Lys Glu Ser Val 
65                  70                  75                  80  


Leu Gln Phe Tyr Pro Lys Ala Asn Ile Val Ala Tyr His Asp Ser Ile 
                85                  90                  95      


Met Asn Pro Asp Tyr Asn Val Glu Phe Phe Arg Gln Phe Ile Leu Val 
            100                 105                 110         


Met Asn Ala Leu Asp Asn Arg Ala Ala Arg Asn His Val Asn Arg Met 
        115                 120                 125             


Cys Leu Ala Ala Asp Val Pro Leu Ile Glu Ser Gly Thr Ala Gly Tyr 
    130                 135                 140                 


Leu Gly Gln Val Thr Thr Ile Lys Lys Gly Val Thr Glu Cys Tyr Glu 
145                 150                 155                 160 


Cys His Pro Lys Pro Thr Gln Arg Thr Phe Pro Gly Cys Thr Ile Arg 
                165                 170                 175     


Asn Thr Pro Ser Glu Pro Ile His Cys Ile Val Trp Ala Lys Tyr Leu 
            180                 185                 190         


Phe Asn Gln Leu Phe Gly Glu Glu Asp Ala Asp Gln Glu Val Ser Pro 
        195                 200                 205             


Asp Arg Ala Asp Pro Glu Ala Ala Trp Glu Pro Thr Glu Ala Glu Ala 
    210                 215                 220                 


Arg Ala Arg Ala Ser Asn Glu Asp Gly Asp Ile Lys Arg Ile Ser Thr 
225                 230                 235                 240 


Lys Glu Trp Ala Lys Ser Thr Gly Tyr Asp Pro Val Lys Leu Phe Thr 
                245                 250                 255     


Lys Leu Phe Lys Asp Asp Ile Arg Tyr Leu Leu Thr Met Asp Lys Leu 
            260                 265                 270         


Trp Arg Lys Arg Lys Pro Pro Val Pro Leu Asp Trp Ala Glu Val Gln 
        275                 280                 285             


Ser Gln Gly Glu Glu Thr Asn Ala Ser Asp Gln Gln Asn Glu Pro Gln 
    290                 295                 300                 


Leu Gly Leu Lys Asp Gln Gln Val Leu Asp Val Lys Ser Tyr Ala Arg 
305                 310                 315                 320 


Leu Phe Ser Lys Ser Ile Glu Thr Leu Arg Val His Leu Ala Glu Lys 
                325                 330                 335     


Gly Asp Gly Ala Glu Leu Ile Trp Asp Lys Asp Asp Pro Ser Ala Met 
            340                 345                 350         


Asp Phe Val Thr Ser Ala Ala Asn Leu Arg Met His Ile Phe Ser Met 
        355                 360                 365             


Asn Met Lys Ser Arg Phe Asp Ile Lys Ser Met Ala Gly Asn Ile Ile 
    370                 375                 380                 


Pro Ala Ile Ala Thr Thr Asn Ala Val Ile Ala Gly Leu Ile Val Leu 
385                 390                 395                 400 


Glu Gly Leu Lys Ile Leu Ser Gly Lys Ile Asp Gln Cys Arg Thr Ile 
                405                 410                 415     


Phe Leu Asn Lys Gln Pro Asn Pro Arg Lys Lys Leu Leu Val Pro Cys 
            420                 425                 430         


Ala Leu Asp Pro Pro Asn Pro Asn Cys Tyr Val Cys Ala Ser Lys Pro 
        435                 440                 445             


Glu Val Thr Val Arg Leu Asn Val His Lys Val Thr Val Leu Thr Leu 
    450                 455                 460                 


Gln Asp Lys Ile Val Lys Glu Lys Phe Ala Met Val Ala Pro Asp Val 
465                 470                 475                 480 


Gln Ile Glu Asp Gly Lys Gly Thr Ile Leu Ile Ser Ser Glu Glu Gly 
                485                 490                 495     


Glu Thr Glu Ala Asn Asn His Lys Lys Leu Ser Glu Phe Gly Ile Arg 
            500                 505                 510         


Asn Gly Ser Arg Leu Gln Ala Asp Asp Phe Leu Gln Asp Tyr Thr Leu 
        515                 520                 525             


Leu Ile Asn Ile Leu His Ser Glu Asp Leu Gly Lys Asp Val Glu Phe 
    530                 535                 540                 


Glu Val Val Gly Asp Ala Pro Glu Lys Val Gly Pro Lys Gln Ala Glu 
545                 550                 555                 560 


Asp Ala Ala Lys Ser Ile Thr Asn Gly Ser Asp Asp Gly Ala Gln Pro 
                565                 570                 575     


Ser Thr Ser Thr Ala Gln Glu Gln Asp Asp Val Leu Ile Val Asp Ser 
            580                 585                 590         


Asp Glu Glu Asp Ser Ser Asn Asn Ala Asp Val Ser Glu Glu Glu Arg 
        595                 600                 605             


Ser Arg Lys Arg Lys Leu Asp Glu Lys Glu Asn Leu Ser Ala Lys Arg 
    610                 615                 620                 


Ser Arg Ile Glu Gln Lys Glu Glu Leu Asp Asp Val Ile Ala Leu Asp 
625                 630                 635                 640 


<210>  225
<211>  477
<212>  DNA
<213>  Homo sapiens

<400>  225
atgtcgggga tcgccctcag cagactcgcc caggagagga aagcatggag gaaagaccac       60

ccatttggtt tcgtggctgt cccaacaaaa aatcccgatg gcacgatgaa cctcatgaac      120

tgggagtgcg ccattccagg aaagaaaggg actccgtggg aaggaggctt gtttaaacta      180

cggatgcttt tcaaagatga ttatccatct tcgccaccaa aatgtaaatt cgaaccacca      240

ttatttcacc cgaatgtgta cccttcgggg acagtgtgcc tgtccatctt agaggaggac      300

aaggactgga ggccagccat cacaatcaaa cagatcctat taggaataca ggaacttcta      360

aatgaaccaa atatccaaga cccagctcaa gcagaggcct acacgattta ctgccaaaac      420

agagtggagt acgagaaaag ggtccgagca caagccaaga agtttgcgcc ctcataa         477


<210>  226
<211>  158
<212>  PRT
<213>  Homo sapiens

<400>  226

Met Ser Gly Ile Ala Leu Ser Arg Leu Ala Gln Glu Arg Lys Ala Trp 
1               5                   10                  15      


Arg Lys Asp His Pro Phe Gly Phe Val Ala Val Pro Thr Lys Asn Pro 
            20                  25                  30          


Asp Gly Thr Met Asn Leu Met Asn Trp Glu Cys Ala Ile Pro Gly Lys 
        35                  40                  45              


Lys Gly Thr Pro Trp Glu Gly Gly Leu Phe Lys Leu Arg Met Leu Phe 
    50                  55                  60                  


Lys Asp Asp Tyr Pro Ser Ser Pro Pro Lys Cys Lys Phe Glu Pro Pro 
65                  70                  75                  80  


Leu Phe His Pro Asn Val Tyr Pro Ser Gly Thr Val Cys Leu Ser Ile 
                85                  90                  95      


Leu Glu Glu Asp Lys Asp Trp Arg Pro Ala Ile Thr Ile Lys Gln Ile 
            100                 105                 110         


Leu Leu Gly Ile Gln Glu Leu Leu Asn Glu Pro Asn Ile Gln Asp Pro 
        115                 120                 125             


Ala Gln Ala Glu Ala Tyr Thr Ile Tyr Cys Gln Asn Arg Val Glu Tyr 
    130                 135                 140                 


Glu Lys Arg Val Arg Ala Gln Ala Lys Lys Phe Ala Pro Ser 
145                 150                 155             


<210>  227
<211>  2382
<212>  DNA
<213>  Homo sapiens

<400>  227
atgtggatcc aggttcggac catggacggg aggcagaccc acacggtgga ctcgctgtcc       60

aggctgacca aggtggagga gctgaggcgg aagatccagg agctgttcca cgtggagcca      120

ggcctgcaga ggctgttcta caggggcaaa cagatggagg acggccatac cctcttcgac      180

tacgaggtcc gcctgaatga caccatccag ctcctggtcc gccagagcct cgtgctcccc      240

cacagcacca aggagcggga ctccgagctc tccgacaccg actccggctg ctgcctgggc      300

cagagtgagt cagacaagtc ctccacccac ggtgaggcgg ccgccgagac tgacagcagg      360

ccagccgatg aggacatgtg ggatgagacg gaattggggc tgtacaaggt caatgagtac      420

gtcgatgctc gggacacgaa catgggggcg tggtttgagg cgcaggtggt cagggtgacg      480

cggaaggccc cctcccggga cgagccctgc agctccacgt ccaggccggc gctggaggag      540

gacgtcattt accacgtgaa atacgacgac tacccggaga acggcgtggt ccagatgaac      600

tccagggacg tccgagcgcg cgcccgcacc atcatcaagt ggcaggacct ggaggtgggc      660

caggtggtca tgctcaacta caaccccgac aaccccaagg agcggggctt ctggtacgac      720

gcggagatct ccaggaagcg cgagaccagg acggcgcggg aactctacgc caacgtggtg      780

ctgggggatg attctctgaa cgactgtcgg atcatcttcg tggacgaagt cttcaagatt      840

gagcggccgg gtgaagggag ccccatggtt gacaacccca tgagacggaa gagcgggccg      900

tcctgcaagc actgcaagga cgacgtgaac agactctgcc gggtctgcgc ctgccacctg      960

tgcgggggcc ggcaggaccc cgacaagcag ctcatgtgcg atgagtgcga catggccttc     1020

cacatctact gcctggaccc gcccctcagc agtgttccca gcgaggacga gtggtactgc     1080

cctgagtgcc ggaatgatgc cagcgaggtg gtactggcgg gagagcggct gagagagagc     1140

aagaagaagg cgaagatggc ctcggccaca tcgtcctcac agcgggactg gggcaagggc     1200

atggcctgtg tgggccgcac caaggaatgt accatcgtcc cgtccaacca ctacggaccc     1260

atcccgggga tccccgtggg caccatgtgg cggttccgag tccaggtcag cgagtcgggt     1320

gtccatcggc cccacgtggc tggcatacac ggccggagca acgacggagc gtactcccta     1380

gtcctggcgg ggggctatga ggatgatgtg gaccatggga attttttcac atacacgggt     1440

agtggtggtc gagatctttc cggcaacaag aggaccgcgg aacagtcttg tgatcagaaa     1500

ctcaccaaca ccaacagggc gctggctctc aactgctttg ctcccatcaa tgaccaagaa     1560

ggggccgagg ccaaggactg gcggtcgggg aagccggtca gggtggtgcg caatgtcaag     1620

ggtggcaaga atagcaagta cgcccccgct gagggcaacc gctacgatgg catctacaag     1680

gttgtgaaat actggcccga gaaggggaag tccgggtttc tcgtgtggcg ctaccttctg     1740

cggagggacg atgatgagcc tggcccttgg acgaaggagg ggaaggaccg gatcaagaag     1800

ctggggctga ccatgcagta tccagaaggc tacctggaag ccctggccaa ccgagagcga     1860

gagaaggaga acagcaagag ggaggaggag gagcagcagg aggggggctt cgcgtccccc     1920

aggacgggca agggcaagtg gaagcggaag tcggcaggag gtggcccgag cagggccggg     1980

tccccgcgcc ggacatccaa gaaaaccaag gtggagccct acagtctcac ggcccagcag     2040

agcagcctca tcagagagga caagagcaac gccaagctgt ggaatgaggt cctggcgtca     2100

ctcaaggacc ggccggcgag cggcagcccg ttccagttgt tcctgagtaa agtggaggag     2160

acgttccagt gtatctgctg tcaggagctg gtgttccggc ccatcacgac cgtgtgccag     2220

cacaacgtgt gcaaggactg cctggacaga tcctttcggg cacaggtgtt cagctgccct     2280

gcctgccgct acgacctggg ccgcagctat gccatgcagg tgaaccagcc tctgcagacc     2340

gtcctcaacc agctcttccc cggctacggc aatggccggt ga                        2382


<210>  228
<211>  793
<212>  PRT
<213>  Homo sapiens

<400>  228

Met Trp Ile Gln Val Arg Thr Met Asp Gly Arg Gln Thr His Thr Val 
1               5                   10                  15      


Asp Ser Leu Ser Arg Leu Thr Lys Val Glu Glu Leu Arg Arg Lys Ile 
            20                  25                  30          


Gln Glu Leu Phe His Val Glu Pro Gly Leu Gln Arg Leu Phe Tyr Arg 
        35                  40                  45              


Gly Lys Gln Met Glu Asp Gly His Thr Leu Phe Asp Tyr Glu Val Arg 
    50                  55                  60                  


Leu Asn Asp Thr Ile Gln Leu Leu Val Arg Gln Ser Leu Val Leu Pro 
65                  70                  75                  80  


His Ser Thr Lys Glu Arg Asp Ser Glu Leu Ser Asp Thr Asp Ser Gly 
                85                  90                  95      


Cys Cys Leu Gly Gln Ser Glu Ser Asp Lys Ser Ser Thr His Gly Glu 
            100                 105                 110         


Ala Ala Ala Glu Thr Asp Ser Arg Pro Ala Asp Glu Asp Met Trp Asp 
        115                 120                 125             


Glu Thr Glu Leu Gly Leu Tyr Lys Val Asn Glu Tyr Val Asp Ala Arg 
    130                 135                 140                 


Asp Thr Asn Met Gly Ala Trp Phe Glu Ala Gln Val Val Arg Val Thr 
145                 150                 155                 160 


Arg Lys Ala Pro Ser Arg Asp Glu Pro Cys Ser Ser Thr Ser Arg Pro 
                165                 170                 175     


Ala Leu Glu Glu Asp Val Ile Tyr His Val Lys Tyr Asp Asp Tyr Pro 
            180                 185                 190         


Glu Asn Gly Val Val Gln Met Asn Ser Arg Asp Val Arg Ala Arg Ala 
        195                 200                 205             


Arg Thr Ile Ile Lys Trp Gln Asp Leu Glu Val Gly Gln Val Val Met 
    210                 215                 220                 


Leu Asn Tyr Asn Pro Asp Asn Pro Lys Glu Arg Gly Phe Trp Tyr Asp 
225                 230                 235                 240 


Ala Glu Ile Ser Arg Lys Arg Glu Thr Arg Thr Ala Arg Glu Leu Tyr 
                245                 250                 255     


Ala Asn Val Val Leu Gly Asp Asp Ser Leu Asn Asp Cys Arg Ile Ile 
            260                 265                 270         


Phe Val Asp Glu Val Phe Lys Ile Glu Arg Pro Gly Glu Gly Ser Pro 
        275                 280                 285             


Met Val Asp Asn Pro Met Arg Arg Lys Ser Gly Pro Ser Cys Lys His 
    290                 295                 300                 


Cys Lys Asp Asp Val Asn Arg Leu Cys Arg Val Cys Ala Cys His Leu 
305                 310                 315                 320 


Cys Gly Gly Arg Gln Asp Pro Asp Lys Gln Leu Met Cys Asp Glu Cys 
                325                 330                 335     


Asp Met Ala Phe His Ile Tyr Cys Leu Asp Pro Pro Leu Ser Ser Val 
            340                 345                 350         


Pro Ser Glu Asp Glu Trp Tyr Cys Pro Glu Cys Arg Asn Asp Ala Ser 
        355                 360                 365             


Glu Val Val Leu Ala Gly Glu Arg Leu Arg Glu Ser Lys Lys Lys Ala 
    370                 375                 380                 


Lys Met Ala Ser Ala Thr Ser Ser Ser Gln Arg Asp Trp Gly Lys Gly 
385                 390                 395                 400 


Met Ala Cys Val Gly Arg Thr Lys Glu Cys Thr Ile Val Pro Ser Asn 
                405                 410                 415     


His Tyr Gly Pro Ile Pro Gly Ile Pro Val Gly Thr Met Trp Arg Phe 
            420                 425                 430         


Arg Val Gln Val Ser Glu Ser Gly Val His Arg Pro His Val Ala Gly 
        435                 440                 445             


Ile His Gly Arg Ser Asn Asp Gly Ala Tyr Ser Leu Val Leu Ala Gly 
    450                 455                 460                 


Gly Tyr Glu Asp Asp Val Asp His Gly Asn Phe Phe Thr Tyr Thr Gly 
465                 470                 475                 480 


Ser Gly Gly Arg Asp Leu Ser Gly Asn Lys Arg Thr Ala Glu Gln Ser 
                485                 490                 495     


Cys Asp Gln Lys Leu Thr Asn Thr Asn Arg Ala Leu Ala Leu Asn Cys 
            500                 505                 510         


Phe Ala Pro Ile Asn Asp Gln Glu Gly Ala Glu Ala Lys Asp Trp Arg 
        515                 520                 525             


Ser Gly Lys Pro Val Arg Val Val Arg Asn Val Lys Gly Gly Lys Asn 
    530                 535                 540                 


Ser Lys Tyr Ala Pro Ala Glu Gly Asn Arg Tyr Asp Gly Ile Tyr Lys 
545                 550                 555                 560 


Val Val Lys Tyr Trp Pro Glu Lys Gly Lys Ser Gly Phe Leu Val Trp 
                565                 570                 575     


Arg Tyr Leu Leu Arg Arg Asp Asp Asp Glu Pro Gly Pro Trp Thr Lys 
            580                 585                 590         


Glu Gly Lys Asp Arg Ile Lys Lys Leu Gly Leu Thr Met Gln Tyr Pro 
        595                 600                 605             


Glu Gly Tyr Leu Glu Ala Leu Ala Asn Arg Glu Arg Glu Lys Glu Asn 
    610                 615                 620                 


Ser Lys Arg Glu Glu Glu Glu Gln Gln Glu Gly Gly Phe Ala Ser Pro 
625                 630                 635                 640 


Arg Thr Gly Lys Gly Lys Trp Lys Arg Lys Ser Ala Gly Gly Gly Pro 
                645                 650                 655     


Ser Arg Ala Gly Ser Pro Arg Arg Thr Ser Lys Lys Thr Lys Val Glu 
            660                 665                 670         


Pro Tyr Ser Leu Thr Ala Gln Gln Ser Ser Leu Ile Arg Glu Asp Lys 
        675                 680                 685             


Ser Asn Ala Lys Leu Trp Asn Glu Val Leu Ala Ser Leu Lys Asp Arg 
    690                 695                 700                 


Pro Ala Ser Gly Ser Pro Phe Gln Leu Phe Leu Ser Lys Val Glu Glu 
705                 710                 715                 720 


Thr Phe Gln Cys Ile Cys Cys Gln Glu Leu Val Phe Arg Pro Ile Thr 
                725                 730                 735     


Thr Val Cys Gln His Asn Val Cys Lys Asp Cys Leu Asp Arg Ser Phe 
            740                 745                 750         


Arg Ala Gln Val Phe Ser Cys Pro Ala Cys Arg Tyr Asp Leu Gly Arg 
        755                 760                 765             


Ser Tyr Ala Met Gln Val Asn Gln Pro Leu Gln Thr Val Leu Asn Gln 
    770                 775                 780                 


Leu Phe Pro Gly Tyr Gly Asn Gly Arg 
785                 790             


<210>  229
<211>  3216
<212>  DNA
<213>  Homo sapiens

<400>  229
atgccagcaa ttatgacaat gttagcagac catgcagctc gtcagctgct tgatttcagc       60

caaaaactgg atatcaactt attagataat gtggtgaatt gcttatacca tggagaagga      120

gcccagcaaa gaatggctca agaagtactg acacatttaa aggagcatcc tgatgcttgg      180

acaagagtcg acacaatttt ggaattttct cagaatatga atacgaaata ctatggacta      240

caaattttgg aaaatgtgat aaaaacaagg tggaagattc ttccaaggaa ccagtgcgaa      300

ggaataaaaa aatacgttgt tggcctcatt atcaagacgt catctgaccc aacttgtgta      360

gagaaagaaa aggtgtatat cggaaaatta aatatgatcc ttgttcagat actgaaacaa      420

gaatggccca aacattggcc aacttttatc agtgatattg ttggagcaag taggaccagc      480

gaaagtctct gtcaaaataa tatggtgatt cttaaactct tgagtgaaga agtatttgat      540

ttctctagtg gacagataac ccaagtcaaa tctaagcatt taaaagacag catgtgcaat      600

gaattctcac agatatttca actgtgtcag tttgtaatgg aaaattctca aaatgctcca      660

cttgtacatg caaccttgga aacattgctc agatttctga actggattcc cctgggatat      720

atttttgaga ccaaattaat cagcacattg atttataagt tcctgaatgt tccaatgttt      780

cgaaatgtct ctctgaagtg cctcactgag attgctggtg tgagtgtaag ccaatatgaa      840

gaacaatttg taacactatt tactctgaca atgatgcaac taaagcagat gcttccttta      900

aataccaata ttcgacttgc gtactcaaat ggaaaagatg atgaacagaa cttcattcaa      960

aatctcagtt tgtttctctg cacctttctt aaggaacatg atcaacttat agaaaaaaga     1020

ttaaatctca gggaaactct tatggaggcc cttcattata tgttgttggt atctgaagta     1080

gaagaaactg aaatctttaa aatttgtctt gaatactgga atcatttggc tgctgaactc     1140

tatagagaga gtccattctc tacatctgcc tctccgttgc tttctggaag tcaacatttt     1200

gatgttcctc ccaggagaca gctatatttg cccatgttat tcaaggtccg tttattaatg     1260

gttagtcgaa tggctaaacc agaggaagta ttggttgtag agaatgatca aggagaagtt     1320

gtgagagaat tcatgaagga tacagattcc ataaatttgt ataagaatat gagggaaaca     1380

ttggtttatc ttactcatct ggattatgta gatacagaaa gaataatgac agagaagctt     1440

cacaatcaag tgaatggtac agagtggtca tggaaaaatt tgaatacatt gtgttgggca     1500

ataggctcca ttagtggagc aatgcatgaa gaggacgaaa aacgatttct tgttactgtt     1560

ataaaggatc tattaggatt atgtgaacag aaaagaggca aagataataa agctattatt     1620

gcatcaaata tcatgtacat agtaggtcaa tacccacgtt ttttgagagc tcactggaaa     1680

tttctgaaga ctgtagttaa caagctgttc gaattcatgc atgagaccca tgatggagtc     1740

caggatatgg cttgtgatac tttcattaaa atagcccaaa aatgccgcag gcatttcgtt     1800

caggttcagg ttggagaagt gatgccattt attgatgaaa ttttgaacaa cattaacact     1860

attatttgtg atcttcagcc tcaacaggtt catacgtttt atgaagctgt ggggtacatg     1920

attggtgcac aaacagatca aacagtacaa gaacacttga tagaaaagta catgttactc     1980

cctaatcaag tgtgggatag tataatccag caggcaacca aaaatgtgga tatactgaaa     2040

gatcctgaaa cagtcaagca gcttggtagc attttgaaaa caaatgtgag agcctgcaaa     2100

gctgttggac acccctttgt aattcagctt ggaagaattt atttagatat gcttaatgta     2160

tacaagtgcc tcagtgaaaa tatttctgca gctatccaag ctaatggtga aatggttaca     2220

aagcaaccat tgattagaag tatgcgaact gtaaaaaggg aaactttaaa gttaatatct     2280

ggttgggtga gccgatccaa tgatccacag atggtcgctg aaaattttgt tccccctctg     2340

ttggatgcag ttctcattga ttatcagaga aatgtcccag ctgctagaga accagaagtg     2400

cttagtacta tggccataat tgtcaacaag ttagggggac atataacagc tgaaatacct     2460

caaatatttg atgctgtttt tgaatgcaca ttgaatatga taaataagga ctttgaagaa     2520

tatcctgaac atagaacgaa ctttttctta ctacttcagg ctgtcaattc tcattgtttc     2580

ccagcattcc ttgctattcc acctacacag tttaaacttg ttttggattc catcatttgg     2640

gctttcaaac atactatgag gaatgtcgca gatacgggct tacagatact ttttacactc     2700

ttacaaaatg ttgcacaaga agaagctgca gctcagagtt tttatcaaac ttatttttgt     2760

gatattctcc agcatatctt ttctgttgtg acagacactt cacatactgc tggtttaaca     2820

atgcatgcat caattcttgc atatatgttt aatttggttg aagaaggaaa aataagtaca     2880

tcattaaatc ctggaaatcc agttaacaac caaatctttc ttcaggaata tgtggctaat     2940

ctccttaagt cggccttccc tcacctacaa gatgctcaag taaagctctt tgtgacaggg     3000

cttttcagct taaatcaaga tattcctgct ttcaaggaac atttaagaga tttcctagtt     3060

caaataaagg aatttgcagg tgaagacact tctgatttgt ttttggaaga gagagaaata     3120

gccctacggc aggctgatga agagaaacat aaacgtcaaa tgtctgtccc tggcatcttt     3180

aatccacatg agattccaga agaaatgtgt gattaa                               3216


<210>  230
<211>  1071
<212>  PRT
<213>  Homo sapiens

<400>  230

Met Pro Ala Ile Met Thr Met Leu Ala Asp His Ala Ala Arg Gln Leu 
1               5                   10                  15      


Leu Asp Phe Ser Gln Lys Leu Asp Ile Asn Leu Leu Asp Asn Val Val 
            20                  25                  30          


Asn Cys Leu Tyr His Gly Glu Gly Ala Gln Gln Arg Met Ala Gln Glu 
        35                  40                  45              


Val Leu Thr His Leu Lys Glu His Pro Asp Ala Trp Thr Arg Val Asp 
    50                  55                  60                  


Thr Ile Leu Glu Phe Ser Gln Asn Met Asn Thr Lys Tyr Tyr Gly Leu 
65                  70                  75                  80  


Gln Ile Leu Glu Asn Val Ile Lys Thr Arg Trp Lys Ile Leu Pro Arg 
                85                  90                  95      


Asn Gln Cys Glu Gly Ile Lys Lys Tyr Val Val Gly Leu Ile Ile Lys 
            100                 105                 110         


Thr Ser Ser Asp Pro Thr Cys Val Glu Lys Glu Lys Val Tyr Ile Gly 
        115                 120                 125             


Lys Leu Asn Met Ile Leu Val Gln Ile Leu Lys Gln Glu Trp Pro Lys 
    130                 135                 140                 


His Trp Pro Thr Phe Ile Ser Asp Ile Val Gly Ala Ser Arg Thr Ser 
145                 150                 155                 160 


Glu Ser Leu Cys Gln Asn Asn Met Val Ile Leu Lys Leu Leu Ser Glu 
                165                 170                 175     


Glu Val Phe Asp Phe Ser Ser Gly Gln Ile Thr Gln Val Lys Ser Lys 
            180                 185                 190         


His Leu Lys Asp Ser Met Cys Asn Glu Phe Ser Gln Ile Phe Gln Leu 
        195                 200                 205             


Cys Gln Phe Val Met Glu Asn Ser Gln Asn Ala Pro Leu Val His Ala 
    210                 215                 220                 


Thr Leu Glu Thr Leu Leu Arg Phe Leu Asn Trp Ile Pro Leu Gly Tyr 
225                 230                 235                 240 


Ile Phe Glu Thr Lys Leu Ile Ser Thr Leu Ile Tyr Lys Phe Leu Asn 
                245                 250                 255     


Val Pro Met Phe Arg Asn Val Ser Leu Lys Cys Leu Thr Glu Ile Ala 
            260                 265                 270         


Gly Val Ser Val Ser Gln Tyr Glu Glu Gln Phe Val Thr Leu Phe Thr 
        275                 280                 285             


Leu Thr Met Met Gln Leu Lys Gln Met Leu Pro Leu Asn Thr Asn Ile 
    290                 295                 300                 


Arg Leu Ala Tyr Ser Asn Gly Lys Asp Asp Glu Gln Asn Phe Ile Gln 
305                 310                 315                 320 


Asn Leu Ser Leu Phe Leu Cys Thr Phe Leu Lys Glu His Asp Gln Leu 
                325                 330                 335     


Ile Glu Lys Arg Leu Asn Leu Arg Glu Thr Leu Met Glu Ala Leu His 
            340                 345                 350         


Tyr Met Leu Leu Val Ser Glu Val Glu Glu Thr Glu Ile Phe Lys Ile 
        355                 360                 365             


Cys Leu Glu Tyr Trp Asn His Leu Ala Ala Glu Leu Tyr Arg Glu Ser 
    370                 375                 380                 


Pro Phe Ser Thr Ser Ala Ser Pro Leu Leu Ser Gly Ser Gln His Phe 
385                 390                 395                 400 


Asp Val Pro Pro Arg Arg Gln Leu Tyr Leu Pro Met Leu Phe Lys Val 
                405                 410                 415     


Arg Leu Leu Met Val Ser Arg Met Ala Lys Pro Glu Glu Val Leu Val 
            420                 425                 430         


Val Glu Asn Asp Gln Gly Glu Val Val Arg Glu Phe Met Lys Asp Thr 
        435                 440                 445             


Asp Ser Ile Asn Leu Tyr Lys Asn Met Arg Glu Thr Leu Val Tyr Leu 
    450                 455                 460                 


Thr His Leu Asp Tyr Val Asp Thr Glu Arg Ile Met Thr Glu Lys Leu 
465                 470                 475                 480 


His Asn Gln Val Asn Gly Thr Glu Trp Ser Trp Lys Asn Leu Asn Thr 
                485                 490                 495     


Leu Cys Trp Ala Ile Gly Ser Ile Ser Gly Ala Met His Glu Glu Asp 
            500                 505                 510         


Glu Lys Arg Phe Leu Val Thr Val Ile Lys Asp Leu Leu Gly Leu Cys 
        515                 520                 525             


Glu Gln Lys Arg Gly Lys Asp Asn Lys Ala Ile Ile Ala Ser Asn Ile 
    530                 535                 540                 


Met Tyr Ile Val Gly Gln Tyr Pro Arg Phe Leu Arg Ala His Trp Lys 
545                 550                 555                 560 


Phe Leu Lys Thr Val Val Asn Lys Leu Phe Glu Phe Met His Glu Thr 
                565                 570                 575     


His Asp Gly Val Gln Asp Met Ala Cys Asp Thr Phe Ile Lys Ile Ala 
            580                 585                 590         


Gln Lys Cys Arg Arg His Phe Val Gln Val Gln Val Gly Glu Val Met 
        595                 600                 605             


Pro Phe Ile Asp Glu Ile Leu Asn Asn Ile Asn Thr Ile Ile Cys Asp 
    610                 615                 620                 


Leu Gln Pro Gln Gln Val His Thr Phe Tyr Glu Ala Val Gly Tyr Met 
625                 630                 635                 640 


Ile Gly Ala Gln Thr Asp Gln Thr Val Gln Glu His Leu Ile Glu Lys 
                645                 650                 655     


Tyr Met Leu Leu Pro Asn Gln Val Trp Asp Ser Ile Ile Gln Gln Ala 
            660                 665                 670         


Thr Lys Asn Val Asp Ile Leu Lys Asp Pro Glu Thr Val Lys Gln Leu 
        675                 680                 685             


Gly Ser Ile Leu Lys Thr Asn Val Arg Ala Cys Lys Ala Val Gly His 
    690                 695                 700                 


Pro Phe Val Ile Gln Leu Gly Arg Ile Tyr Leu Asp Met Leu Asn Val 
705                 710                 715                 720 


Tyr Lys Cys Leu Ser Glu Asn Ile Ser Ala Ala Ile Gln Ala Asn Gly 
                725                 730                 735     


Glu Met Val Thr Lys Gln Pro Leu Ile Arg Ser Met Arg Thr Val Lys 
            740                 745                 750         


Arg Glu Thr Leu Lys Leu Ile Ser Gly Trp Val Ser Arg Ser Asn Asp 
        755                 760                 765             


Pro Gln Met Val Ala Glu Asn Phe Val Pro Pro Leu Leu Asp Ala Val 
    770                 775                 780                 


Leu Ile Asp Tyr Gln Arg Asn Val Pro Ala Ala Arg Glu Pro Glu Val 
785                 790                 795                 800 


Leu Ser Thr Met Ala Ile Ile Val Asn Lys Leu Gly Gly His Ile Thr 
                805                 810                 815     


Ala Glu Ile Pro Gln Ile Phe Asp Ala Val Phe Glu Cys Thr Leu Asn 
            820                 825                 830         


Met Ile Asn Lys Asp Phe Glu Glu Tyr Pro Glu His Arg Thr Asn Phe 
        835                 840                 845             


Phe Leu Leu Leu Gln Ala Val Asn Ser His Cys Phe Pro Ala Phe Leu 
    850                 855                 860                 


Ala Ile Pro Pro Thr Gln Phe Lys Leu Val Leu Asp Ser Ile Ile Trp 
865                 870                 875                 880 


Ala Phe Lys His Thr Met Arg Asn Val Ala Asp Thr Gly Leu Gln Ile 
                885                 890                 895     


Leu Phe Thr Leu Leu Gln Asn Val Ala Gln Glu Glu Ala Ala Ala Gln 
            900                 905                 910         


Ser Phe Tyr Gln Thr Tyr Phe Cys Asp Ile Leu Gln His Ile Phe Ser 
        915                 920                 925             


Val Val Thr Asp Thr Ser His Thr Ala Gly Leu Thr Met His Ala Ser 
    930                 935                 940                 


Ile Leu Ala Tyr Met Phe Asn Leu Val Glu Glu Gly Lys Ile Ser Thr 
945                 950                 955                 960 


Ser Leu Asn Pro Gly Asn Pro Val Asn Asn Gln Ile Phe Leu Gln Glu 
                965                 970                 975     


Tyr Val Ala Asn Leu Leu Lys Ser Ala Phe Pro His Leu Gln Asp Ala 
            980                 985                 990         


Gln Val Lys Leu Phe Val Thr Gly  Leu Phe Ser Leu Asn  Gln Asp Ile 
        995                 1000                 1005             


Pro Ala  Phe Lys Glu His Leu  Arg Asp Phe Leu Val  Gln Ile Lys 
    1010                 1015                 1020             


Glu Phe  Ala Gly Glu Asp Thr  Ser Asp Leu Phe Leu  Glu Glu Arg 
    1025                 1030                 1035             


Glu Ile  Ala Leu Arg Gln Ala  Asp Glu Glu Lys His  Lys Arg Gln 
    1040                 1045                 1050             


Met Ser  Val Pro Gly Ile Phe  Asn Pro His Glu Ile  Pro Glu Glu 
    1055                 1060                 1065             


Met Cys  Asp 
    1070     


<210>  231
<211>  1056
<212>  DNA
<213>  Homo sapiens

<400>  231
atgggcaacg ccgccgccgc caagaagggc agcgagcagg agagcgtgaa agaattctta       60

gccaaagcca aagaagattt tcttaaaaaa tgggaaagtc ccgctcagaa cacagcccac      120

ttggatcagt ttgaacgaat caagaccctc ggcacgggct ccttcgggcg ggtgatgctg      180

gtgaaacaca aggagaccgg gaaccactat gccatgaaga tcctcgacaa acagaaggtg      240

gtgaaactga aacagatcga acacaccctg aatgaaaagc gcatcctgca agctgtcaac      300

tttccgttcc tcgtcaaact cgagttctcc ttcaaggaca actcaaactt atacatggtc      360

atggagtacg tgcccggcgg ggagatgttc tcacacctac ggcggatcgg aaggttcagt      420

gagccccatg cccgtttcta cgcggcccag atcgtcctga cctttgagta tctgcactcg      480

ctggatctca tctacaggga cctgaagccg gagaatctgc tcattgacca gcagggctac      540

attcaggtga cagacttcgg tttcgccaag cgcgtgaagg gccgcacttg gaccttgtgc      600

ggcacccctg agtacctggc ccctgagatt atcctgagca aaggctacaa caaggccgtg      660

gactggtggg ccctgggggt tcttatctat gaaatggccg ctggctaccc gcccttcttc      720

gcagaccagc ccatccagat ctatgagaag atcgtctctg ggaaggtgcg cttcccttcc      780

cacttcagct ctgacttgaa ggacctgctg cggaacctcc tgcaggtaga tctcaccaag      840

cgctttggga acctcaagaa tggggtcaac gatatcaaga accacaagtg gtttgccaca      900

actgactgga ttgccatcta ccagaggaag gtggaagctc ccttcatacc aaagtttaaa      960

ggccctgggg atacgagtaa ctttgacgac tatgaggaag aagaaatccg ggtctccatc     1020

aatgagaagt gtggcaagga gttttctgag ttttag                               1056


<210>  232
<211>  351
<212>  PRT
<213>  Homo sapiens

<400>  232

Met Gly Asn Ala Ala Ala Ala Lys Lys Gly Ser Glu Gln Glu Ser Val 
1               5                   10                  15      


Lys Glu Phe Leu Ala Lys Ala Lys Glu Asp Phe Leu Lys Lys Trp Glu 
            20                  25                  30          


Ser Pro Ala Gln Asn Thr Ala His Leu Asp Gln Phe Glu Arg Ile Lys 
        35                  40                  45              


Thr Leu Gly Thr Gly Ser Phe Gly Arg Val Met Leu Val Lys His Lys 
    50                  55                  60                  


Glu Thr Gly Asn His Tyr Ala Met Lys Ile Leu Asp Lys Gln Lys Val 
65                  70                  75                  80  


Val Lys Leu Lys Gln Ile Glu His Thr Leu Asn Glu Lys Arg Ile Leu 
                85                  90                  95      


Gln Ala Val Asn Phe Pro Phe Leu Val Lys Leu Glu Phe Ser Phe Lys 
            100                 105                 110         


Asp Asn Ser Asn Leu Tyr Met Val Met Glu Tyr Val Pro Gly Gly Glu 
        115                 120                 125             


Met Phe Ser His Leu Arg Arg Ile Gly Arg Phe Ser Glu Pro His Ala 
    130                 135                 140                 


Arg Phe Tyr Ala Ala Gln Ile Val Leu Thr Phe Glu Tyr Leu His Ser 
145                 150                 155                 160 


Leu Asp Leu Ile Tyr Arg Asp Leu Lys Pro Glu Asn Leu Leu Ile Asp 
                165                 170                 175     


Gln Gln Gly Tyr Ile Gln Val Thr Asp Phe Gly Phe Ala Lys Arg Val 
            180                 185                 190         


Lys Gly Arg Thr Trp Thr Leu Cys Gly Thr Pro Glu Tyr Leu Ala Pro 
        195                 200                 205             


Glu Ile Ile Leu Ser Lys Gly Tyr Asn Lys Ala Val Asp Trp Trp Ala 
    210                 215                 220                 


Leu Gly Val Leu Ile Tyr Glu Met Ala Ala Gly Tyr Pro Pro Phe Phe 
225                 230                 235                 240 


Ala Asp Gln Pro Ile Gln Ile Tyr Glu Lys Ile Val Ser Gly Lys Val 
                245                 250                 255     


Arg Phe Pro Ser His Phe Ser Ser Asp Leu Lys Asp Leu Leu Arg Asn 
            260                 265                 270         


Leu Leu Gln Val Asp Leu Thr Lys Arg Phe Gly Asn Leu Lys Asn Gly 
        275                 280                 285             


Val Asn Asp Ile Lys Asn His Lys Trp Phe Ala Thr Thr Asp Trp Ile 
    290                 295                 300                 


Ala Ile Tyr Gln Arg Lys Val Glu Ala Pro Phe Ile Pro Lys Phe Lys 
305                 310                 315                 320 


Gly Pro Gly Asp Thr Ser Asn Phe Asp Asp Tyr Glu Glu Glu Glu Ile 
                325                 330                 335     


Arg Val Ser Ile Asn Glu Lys Cys Gly Lys Glu Phe Ser Glu Phe 
            340                 345                 350     


