                         SEQUENCE LISTING

<110>  Centre National de la Recherche Scientifique (CNRS)
 
<120>  Identification du tropisme cellulaire de virus

<130>  BFF09P0281

<160>  40    

<170>  PatentIn version 3.4

<210>  1
<211>  4320
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1038)..(1052)

<220>
<221>  CDS
<222>  (3185)..(4225)

<400>  1
tttcatctct ccgggcttat ttgctggttt ctccgaatgc gggccttgtc tggttcacgc     60

tggatcccca acgcctagaa cagtgcgtgg cacgcagttc gtccttctat aaatatcgga    120

ctaaatgcat ctctgtgatg gtaataccca cacggtgttg tgagaatgaa tgagtgattc    180

tgtgcaagtt cctagtgatc tgttacaaaa agtactggtc gctaaattac tcttataata    240

aagcatactt ttaggataat aaagcactat tcgcgaattg gttaccgcta ttatgaaatt    300

actgagcaat acatatctac atctgatcag tctccagaat tatgccaaat cctaccttct    360

tctgaaagta tctcctaatt atctgcacct gaccctagtg atgctgtgaa tgtgcaagta    420

tagctacatc ctccgaagga aggatcttta ctccttttac ctcctgaatg ggctgcgtct    480

gctgaaagcg cgggggaatg ggcggttgga agcttggccc tacttccagc attgccgcct    540

actggttggg ttactccagc aagtcactcc ccttccctgg gcctcagtgt ctctactgta    600

gcattcccag gtctggaatt ccatccactt tagcaaggat ggacgcgcca cagagagacg    660

cgttcctagc ccgcgcttcc cacctgtctt caggcgcatc ccgcttccct caaacttagg    720

aaatgcctct gggaggtcct gtccggctcc ggactcacta ccgaccaccc gcaaacagca    780

gggtcccctg ggcttcccaa gccgcgcacc tctccgcccc gcccctgcgc cctccttcct    840

cgcgtctgcc cctctccccc accccgcctt ctccctcccc gccccagcgg cgcatgcgcc    900

gcgctcggag cgtgttttta taaaagtccg gccgcggcca gaaacttcag tttgttggct    960

gcggcagcag gtagcaaagt gacgccgagg gcctgagtgc tccagtagcc accgcatctg   1020

gagaaccagc ggttacc atg gag ggg atc agt gtaagtccag tttcaacctg        1072
                   Met Glu Gly Ile Ser                                  
                   1               5                                    

ctttgtcata aatgtacaaa cgtttgaact tagagcgcag cccctctccg agcgggcaga   1132

agcggccagg acattggagg tacccgtact ccaaaaaagg gtcaccgaaa ggagttttct   1192

tgaccatgcc tatatagtgc gggtgggtgg ggggggagca ggattggaat ctttttctct   1252

gtgagtcgag gagaaacgac tggaaagagc gttccagtgg ctgcatgtgt ctcccccttg   1312

agtcccgccg cgcgcggcgg cttgcacgct gtttgcaaac gtaagaacat tctgtgcaca   1372

agtgcagaga aggcgtgcgc gctgcctcgg gactcagacc accggtctct tccttgggga   1432

agcggggatg tcttggagcg agttacattg tctgaattta gaggcggagg gcggcgtgcc   1492

tgggctgact tcccaggagg agattgcgcc cgctttaact tcggggttaa gcgcctggtg   1552

actgttcttg acactgggtg cgtgtttgtt aaactctgtg cggccgacgg agctgtgcca   1612

gtctcccagc acagtaggca gagggcggga gaggcgggtg gacccaccgc gccgatcctc   1672

tgaggggatc gagtggtggc agcagctagg agttgatccg cccgcgcgct ttgggtttga   1732

gggggaaacc ttcccgccgt ccgaagcgcg cctcttcccc acggccgcga gtgggtcctg   1792

cagttcgaga gtttggggtc gtgcagaggt cagcggagtg gtttgacctc ccctttgaca   1852

ccgcgcagct gccagccctg agatttgcgc tccggggata ggagcgggta cggggtgagg   1912

ggcgggggcg gttaagaccg cacctgggct gccaggtcgc cgccgcgaag actggcaggt   1972

gcaagtgggg aaaccgtttg gctctctccg agtccagttg tgatgtttaa ccgtcggtgg   2032

tttccagaaa ccttttgaaa ccctcttgct agggagtttt tggtttcctg cagcggcgcg   2092

caattcaaag acgctcgcgg cggagccgcc cagtcgctcc ccagcaccct gtgggacaga   2152

gcctggcgtg tcgcccagcg gagcccctgc agcgctgctt gcgggcggtt ggcgtgggtg   2212

tagtgggcag ccgcggcggc ccggggctgg acgacccggc cccccgcgtg cccaccgcct   2272

ggaggcttcc agctgcccac ctccggccgg gttaactgga tcagtggcgg ggtaatggga   2332

agccacccgg gagagtgagg aaatgaaact tggggcgagg accacgggtg cagaccccgt   2392

taccttctcc acccaggaaa atgccccgct ccctaacgtc ccaaacgcgc caagtgataa   2452

acacgaggat ggcaagagac ccacacaccg gaggagcgcc cgcttggggg aggaggtgcc   2512

gtttgttcat tttctgacac tcccgcccaa tataccccaa gcaccgaagg gccttcgttt   2572

taagaccgca ttctctttac ccactacaag ttgcttgaag cccagaatgg tttgtattta   2632

ggcaggcgtg ggaaaattaa gtttttgcgc tttaggagaa tgagtctttg caacgccccc   2692

gccctccccc cgtgatcctc ccttctcccc tcttccctcc ctgggcgaaa aacttcttac   2752

aaaaagttaa tcactgcccc tcctagcagc acccacccca ccccccacgc cgcctgggag   2812

tggcctcttt gtgtgtattt tttttttcct cctaaggaag gttttttttc ttccctctag   2872

tgggcggggc agaggagtta gccaagatgt gactttgaaa ccctcagcgt ctcagtgccc   2932

ttttgttcta aacaaagaat tttgtaattg gttctaccaa agaaggatat aatgaagtca   2992

ctatgggaaa agatggggag gagagttgta ggattctaca ttaattctct tgtgccctta   3052

gcccactact tcagaatttc ctgaagaaag caagcctgaa ttggtttttt aaattgcttt   3112

aaaaattttt tttaactggg ttaatgcttg ctgaattgga agtgaatgtc cattcctttg   3172

cctcttttgc ag ata tac act tca gat aac tac acc gag gaa atg ggc tca   3223
              Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu Met Gly Ser       
                              10                  15                    

ggg gac tat gac tcc atg aag gaa ccc tgt ttc cgt gaa gaa aat gct     3271
Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys Phe Arg Glu Glu Asn Ala         
    20                  25                  30                          

aat ttc aat aaa atc ttc ctg ccc acc atc tac tcc atc atc ttc tta     3319
Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile Tyr Ser Ile Ile Phe Leu         
35                  40                  45                  50          

act ggc att gtg ggc aat gga ttg gtc atc ctg gtc atg ggt tac cag     3367
Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met Gly Tyr Gln         
                55                  60                  65              

aag aaa ctg aga agc atg acg gac aag tac agg ctg cac ctg tca gtg     3415
Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu His Leu Ser Val         
            70                  75                  80                  

gcc gac ctc ctc ttt gtc atc acg ctt ccc ttc tgg gca gtt gat gcc     3463
Ala Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp Ala Val Asp Ala         
        85                  90                  95                      

gtg gca aac tgg tac ttt ggg aac ttc cta tgc aag gca gtc cat gtc     3511
Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu Cys Lys Ala Val His Val         
    100                 105                 110                         

atc tac aca gtc aac ctc tac agc agt gtc ctc atc ctg gcc ttc atc     3559
Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile Leu Ala Phe Ile         
115                 120                 125                 130         

agt ctg gac cgc tac ctg gcc atc gtc cac gcc acc aac agt cag agg     3607
Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn Ser Gln Arg         
                135                 140                 145             

cca agg aag ctg ttg gct gaa aag gtg gtc tat gtt ggc gtc tgg atc     3655
Pro Arg Lys Leu Leu Ala Glu Lys Val Val Tyr Val Gly Val Trp Ile         
            150                 155                 160                 

cct gcc ctc ctg ctg act att ccc gac ttc atc ttt gcc aac gtc agt     3703
Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe Ala Asn Val Ser         
        165                 170                 175                     

gag gca gat gac aga tat atc tgt gac cgc ttc tac ccc aat gac ttg     3751
Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg Phe Tyr Pro Asn Asp Leu         
    180                 185                 190                         

tgg gtg gtt gtg ttc cag ttt cag cac atc atg gtt ggc ctt atc ctg     3799
Trp Val Val Val Phe Gln Phe Gln His Ile Met Val Gly Leu Ile Leu         
195                 200                 205                 210         

cct ggt att gtc atc ctg tcc tgc tat tgc att atc atc tcc aag ctg     3847
Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile Ser Lys Leu         
                215                 220                 225             

tca cac tcc aag ggc cac cag aag cgc aag gcc ctc aag acc aca gtc     3895
Ser His Ser Lys Gly His Gln Lys Arg Lys Ala Leu Lys Thr Thr Val         
            230                 235                 240                 

atc ctc atc ctg gct ttc ttc gcc tgt tgg ctg cct tac tac att ggg     3943
Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr Tyr Ile Gly         
        245                 250                 255                     

atc agc atc gac tcc ttc atc ctc ctg gaa atc atc aag caa ggg tgt     3991
Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu Ile Ile Lys Gln Gly Cys         
    260                 265                 270                         

gag ttt gag aac act gtg cac aag tgg att tcc atc acc gag gcc cta     4039
Glu Phe Glu Asn Thr Val His Lys Trp Ile Ser Ile Thr Glu Ala Leu         
275                 280                 285                 290         

gct ttc ttc cac tgt tgt ctg aac ccc atc ctc tat gct ttc ctt gga     4087
Ala Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala Phe Leu Gly         
                295                 300                 305             

gcc aaa ttt aaa acc tct gcc cag cac gca ctc acc tct gtg agc aga     4135
Ala Lys Phe Lys Thr Ser Ala Gln His Ala Leu Thr Ser Val Ser Arg         
            310                 315                 320                 

ggg tcc agc ctc aag atc ctc tcc aaa gga aag cga ggt gga cat tca     4183
Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly Gly His Ser         
        325                 330                 335                     

tct gtt tcc act gag tct gag tct tca agt ttt cac tcc agc             4225
Ser Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His Ser Ser                 
    340                 345                 350                         

taacacagat gtaaaagact tttttttata cgataaataa ctttttttta agttacacat   4285

ttttcagata taaaagactg accaatattg tacag                              4320


<210>  2
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Glu Gly Ile Ser Ile Tyr Thr Ser Asp Asn Tyr Thr Glu Glu Met 
1               5                   10                  15      


Gly Ser Gly Asp Tyr Asp Ser Met Lys Glu Pro Cys Phe Arg Glu Glu 
            20                  25                  30          


Asn Ala Asn Phe Asn Lys Ile Phe Leu Pro Thr Ile Tyr Ser Ile Ile 
        35                  40                  45              


Phe Leu Thr Gly Ile Val Gly Asn Gly Leu Val Ile Leu Val Met Gly 
    50                  55                  60                  


Tyr Gln Lys Lys Leu Arg Ser Met Thr Asp Lys Tyr Arg Leu His Leu 
65                  70                  75                  80  


Ser Val Ala Asp Leu Leu Phe Val Ile Thr Leu Pro Phe Trp Ala Val 
                85                  90                  95      


Asp Ala Val Ala Asn Trp Tyr Phe Gly Asn Phe Leu Cys Lys Ala Val 
            100                 105                 110         


His Val Ile Tyr Thr Val Asn Leu Tyr Ser Ser Val Leu Ile Leu Ala 
        115                 120                 125             


Phe Ile Ser Leu Asp Arg Tyr Leu Ala Ile Val His Ala Thr Asn Ser 
    130                 135                 140                 


Gln Arg Pro Arg Lys Leu Leu Ala Glu Lys Val Val Tyr Val Gly Val 
145                 150                 155                 160 


Trp Ile Pro Ala Leu Leu Leu Thr Ile Pro Asp Phe Ile Phe Ala Asn 
                165                 170                 175     


Val Ser Glu Ala Asp Asp Arg Tyr Ile Cys Asp Arg Phe Tyr Pro Asn 
            180                 185                 190         


Asp Leu Trp Val Val Val Phe Gln Phe Gln His Ile Met Val Gly Leu 
        195                 200                 205             


Ile Leu Pro Gly Ile Val Ile Leu Ser Cys Tyr Cys Ile Ile Ile Ser 
    210                 215                 220                 


Lys Leu Ser His Ser Lys Gly His Gln Lys Arg Lys Ala Leu Lys Thr 
225                 230                 235                 240 


Thr Val Ile Leu Ile Leu Ala Phe Phe Ala Cys Trp Leu Pro Tyr Tyr 
                245                 250                 255     


Ile Gly Ile Ser Ile Asp Ser Phe Ile Leu Leu Glu Ile Ile Lys Gln 
            260                 265                 270         


Gly Cys Glu Phe Glu Asn Thr Val His Lys Trp Ile Ser Ile Thr Glu 
        275                 280                 285             


Ala Leu Ala Phe Phe His Cys Cys Leu Asn Pro Ile Leu Tyr Ala Phe 
    290                 295                 300                 


Leu Gly Ala Lys Phe Lys Thr Ser Ala Gln His Ala Leu Thr Ser Val 
305                 310                 315                 320 


Ser Arg Gly Ser Ser Leu Lys Ile Leu Ser Lys Gly Lys Arg Gly Gly 
                325                 330                 335     


His Ser Ser Val Ser Thr Glu Ser Glu Ser Ser Ser Phe His Ser Ser 
            340                 345                 350         


<210>  3
<211>  1560
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (358)..(1416)

<400>  3
cttcagatag attatatctg gagtgaagaa tcctgccacc tatgtatctg gcatagtatt     60

ctgtgtagtg ggatgagcag agaacaaaaa caaaataatc cagtgagaaa agcccgtaaa    120

taaaccttca gaccagagat ctattctcta gcttatttta agctcaactt aaaaagaaga    180

actgttctct gattcttttc gccttcaata cacttaatga tttaactcca ccctccttca    240

aaagaaacag catttcctac ttttatactg tctatatgat tgatttgcac agctcatctg    300

gccagaagag ctgagacatc cgttccccta caagaaactc tccccgggtg gaacaag       357

atg gat tat caa gtg tca agt cca atc tat gac atc aat tat tat aca      405
Met Asp Tyr Gln Val Ser Ser Pro Ile Tyr Asp Ile Asn Tyr Tyr Thr         
1               5                   10                  15              

tcg gag ccc tgc caa aaa atc aat gtg aag caa atc gca gcc cgc ctc      453
Ser Glu Pro Cys Gln Lys Ile Asn Val Lys Gln Ile Ala Ala Arg Leu         
            20                  25                  30                  

ctg cct ccg ctc tac tca ctg gtg ttc atc ttt ggt ttt gtg ggc aac      501
Leu Pro Pro Leu Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn         
        35                  40                  45                      

atg ctg gtc atc ctc atc ctg ata aac tgc aaa agg ctg aag agc atg      549
Met Leu Val Ile Leu Ile Leu Ile Asn Cys Lys Arg Leu Lys Ser Met         
    50                  55                  60                          

act gac atc tac ctg ctc aac ctg gcc atc tct gac ctg ttt ttc ctt      597
Thr Asp Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp Leu Phe Phe Leu         
65                  70                  75                  80          

ctt act gtc ccc ttc tgg gct cac tat gct gcc gcc cag tgg gac ttt      645
Leu Thr Val Pro Phe Trp Ala His Tyr Ala Ala Ala Gln Trp Asp Phe         
                85                  90                  95              

gga aat aca atg tgt caa ctc ttg aca ggg ctc tat ttt ata ggc ttc      693
Gly Asn Thr Met Cys Gln Leu Leu Thr Gly Leu Tyr Phe Ile Gly Phe         
            100                 105                 110                 

ttc tct gga atc ttc ttc atc atc ctc ctg aca atc gat agg tac ctg      741
Phe Ser Gly Ile Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu         
        115                 120                 125                     

gct gtc gtc cat gct gtg ttt gct tta aaa gcc agg acg gtc acc ttt      789
Ala Val Val His Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe         
    130                 135                 140                         

ggg gtg gtg aca agt gtg atc act tgg gtg gtg gct gtg ttt gcg tct      837
Gly Val Val Thr Ser Val Ile Thr Trp Val Val Ala Val Phe Ala Ser         
145                 150                 155                 160         

ctc cca gga atc atc ttt acc aga tct caa aaa gaa ggt ctt cat tac      885
Leu Pro Gly Ile Ile Phe Thr Arg Ser Gln Lys Glu Gly Leu His Tyr         
                165                 170                 175             

acc tgc agc tct cat ttt cca tac agt cag tat caa ttc tgg aag aat      933
Thr Cys Ser Ser His Phe Pro Tyr Ser Gln Tyr Gln Phe Trp Lys Asn         
            180                 185                 190                 

ttc cag aca tta aag ata gtc atc ttg ggg ctg gtc ctg ccg ctg ctt      981
Phe Gln Thr Leu Lys Ile Val Ile Leu Gly Leu Val Leu Pro Leu Leu         
        195                 200                 205                     

gtc atg gtc atc tgc tac tcg gga atc cta aaa act ctg ctt cgg tgt     1029
Val Met Val Ile Cys Tyr Ser Gly Ile Leu Lys Thr Leu Leu Arg Cys         
    210                 215                 220                         

cga aat gag aag aag agg cac agg gct gtg agg ctt atc ttc acc atc     1077
Arg Asn Glu Lys Lys Arg His Arg Ala Val Arg Leu Ile Phe Thr Ile         
225                 230                 235                 240         

atg att gtt tat ttt ctc ttc tgg gct ccc tac aac att gtc ctt ctc     1125
Met Ile Val Tyr Phe Leu Phe Trp Ala Pro Tyr Asn Ile Val Leu Leu         
                245                 250                 255             

ctg aac acc ttc cag gaa ttc ttt ggc ctg aat aat tgc agt agc tct     1173
Leu Asn Thr Phe Gln Glu Phe Phe Gly Leu Asn Asn Cys Ser Ser Ser         
            260                 265                 270                 

aac agg ttg gac caa gct atg cag gtg aca gag act ctt ggg atg acg     1221
Asn Arg Leu Asp Gln Ala Met Gln Val Thr Glu Thr Leu Gly Met Thr         
        275                 280                 285                     

cac tgc tgc atc aac ccc atc atc tat gcc ttt gtc ggg gag aag ttc     1269
His Cys Cys Ile Asn Pro Ile Ile Tyr Ala Phe Val Gly Glu Lys Phe         
    290                 295                 300                         

aga aac tac ctc tta gtc ttc ttc caa aag cac att gcc aaa cgc ttc     1317
Arg Asn Tyr Leu Leu Val Phe Phe Gln Lys His Ile Ala Lys Arg Phe         
305                 310                 315                 320         

tgc aaa tgc tgt tct att ttc cag caa gag gct ccc gag cga gca agc     1365
Cys Lys Cys Cys Ser Ile Phe Gln Gln Glu Ala Pro Glu Arg Ala Ser         
                325                 330                 335             

tca gtt tac acc cga tcc act ggg gag cag gaa ata tct gtg ggc ttg     1413
Ser Val Tyr Thr Arg Ser Thr Gly Glu Gln Glu Ile Ser Val Gly Leu         
            340                 345                 350                 

tga cacggactca agtgggctgg tgacccagtc agagttgtgc acatggctta          1466

gttttcatac acagcctggg ctgggggtgg ggtgggagag gtctttttta aaaggaagtt   1526

actgttatag agggtctaag attcatccat ttat                               1560


<210>  4
<211>  352
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Asp Tyr Gln Val Ser Ser Pro Ile Tyr Asp Ile Asn Tyr Tyr Thr 
1               5                   10                  15      


Ser Glu Pro Cys Gln Lys Ile Asn Val Lys Gln Ile Ala Ala Arg Leu 
            20                  25                  30          


Leu Pro Pro Leu Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn 
        35                  40                  45              


Met Leu Val Ile Leu Ile Leu Ile Asn Cys Lys Arg Leu Lys Ser Met 
    50                  55                  60                  


Thr Asp Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp Leu Phe Phe Leu 
65                  70                  75                  80  


Leu Thr Val Pro Phe Trp Ala His Tyr Ala Ala Ala Gln Trp Asp Phe 
                85                  90                  95      


Gly Asn Thr Met Cys Gln Leu Leu Thr Gly Leu Tyr Phe Ile Gly Phe 
            100                 105                 110         


Phe Ser Gly Ile Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu 
        115                 120                 125             


Ala Val Val His Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe 
    130                 135                 140                 


Gly Val Val Thr Ser Val Ile Thr Trp Val Val Ala Val Phe Ala Ser 
145                 150                 155                 160 


Leu Pro Gly Ile Ile Phe Thr Arg Ser Gln Lys Glu Gly Leu His Tyr 
                165                 170                 175     


Thr Cys Ser Ser His Phe Pro Tyr Ser Gln Tyr Gln Phe Trp Lys Asn 
            180                 185                 190         


Phe Gln Thr Leu Lys Ile Val Ile Leu Gly Leu Val Leu Pro Leu Leu 
        195                 200                 205             


Val Met Val Ile Cys Tyr Ser Gly Ile Leu Lys Thr Leu Leu Arg Cys 
    210                 215                 220                 


Arg Asn Glu Lys Lys Arg His Arg Ala Val Arg Leu Ile Phe Thr Ile 
225                 230                 235                 240 


Met Ile Val Tyr Phe Leu Phe Trp Ala Pro Tyr Asn Ile Val Leu Leu 
                245                 250                 255     


Leu Asn Thr Phe Gln Glu Phe Phe Gly Leu Asn Asn Cys Ser Ser Ser 
            260                 265                 270         


Asn Arg Leu Asp Gln Ala Met Gln Val Thr Glu Thr Leu Gly Met Thr 
        275                 280                 285             


His Cys Cys Ile Asn Pro Ile Ile Tyr Ala Phe Val Gly Glu Lys Phe 
    290                 295                 300                 


Arg Asn Tyr Leu Leu Val Phe Phe Gln Lys His Ile Ala Lys Arg Phe 
305                 310                 315                 320 


Cys Lys Cys Cys Ser Ile Phe Gln Gln Glu Ala Pro Glu Arg Ala Ser 
                325                 330                 335     


Ser Val Tyr Thr Arg Ser Thr Gly Glu Gln Glu Ile Ser Val Gly Leu 
            340                 345                 350         


<210>  5
<211>  5160
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (4015)..(5082)

<400>  5
ttcttcctaa atttatttac aaatgtaaca caattccacc caaacttatg tttttataag     60

taattgagta gatgatccta aagtttaata aaacaaatgg ctctaatagg taagacattt    120

ggaaatgtat aatgaaaggg agttgcataa taagatcatc tatataaatc atctaataaa    180

tctacaataa aaagtgtctc tagcacagaa ataagatatc aatagaatat aaggtacaaa    240

atcagattca ggaacattaa agaatatacg acaaaggtga tatttcaagc ccaaagggga    300

gaagatggtt attcaacaca tagtgtttta aaatttgtca gataagaatg gagaggagga    360

ggctcctctc ctctgacccc agggaatgtg agaagagaca cagtggttat gaaaggaagc    420

agtcacacct gtggatccct accttcccca tcagagctag ggggcatgga gcgctctctg    480

ctaagatggg gacccccaag gaatgtctcc ctgtggggca cttccttacc agatgggatg    540

gccagtgcgg ttaagttggt ggtcaggcag aaaaaaaaga tctagtttgt actcttgaga    600

gttcctcggt ttgttcatgg catgggcagg gagtcaagga gcagcagcct tgcctcagtg    660

cctaccagtg caggaaaagg tgcatagcct gggccagggc cagggccctg gtggaggcgt    720

agtggtaaca gagagggctc tccattccag cccaaggaag actaagaatg aatacctcat    780

gagtatatta gctacaaacc accacagcag gttccagaaa aaggctcagc gttggaacca    840

ggtcaccccc actcagcaga caccagtcat ataaatcaag gaccaacagg agacaggaac    900

acccccttcc cactctgccc catgtctcaa gttgtagtgg cccttcctcc agatctctgc    960

caccatctta gaaaggaaca ctgaaagaag aaactgaaat tataagctga cagcataaag   1020

aggatgagta aaacctaaaa tcattgttca aatgaatgaa tcaagagaag tttaaaccac   1080

tttggactaa aatgtgtgaa tcctttttcc tgctatccag cagatgagaa gctggtaaca   1140

gagaccaaaa tagtttggag actaaagaat cattgcacat ttcactgctg agttgtattg   1200

tgagtaattt tagttgacct cacttttgta aatcttgcac acgggcatcc atatctgcac   1260

agagatatgt taacagtggt aaatgctgca tgaggagatt gggtgatttt tactttcgtt   1320

tttgtgctct tctttcttat tgttcttact tatttacgat taccctatcg ttttccaaaa   1380

tgtaaaaggc cattttgaaa gcctaattca aacctcttca ctattttgta tctaagtatt   1440

caccttgatt gagactgggt agacaggtga aaaccatatc aggtttttaa ttttttaatt   1500

tttaattatt tatttattta tttatttttt gagatggagt ctggctgtcg cccaggctgg   1560

agtgcagcgg cgtgatcaca gttcactgca gcctcaacct tctaggctca agggattctc   1620

ccacctcagc cccccaagta gttgggacca cacgtatgcg ccaccatgcc tggctaattt   1680

cttatttttt tgtagagata ggatctcact atattgtcca ggctggtctt gaattcctgg   1740

gctcaggtga gcctcccacc tgggcctccc aaagtactgg gattacaggc atgagccaag   1800

gtcccctgcc catatgagat tttctgtctc tgatcccatg cagctagtaa tcaaggactt   1860

ggctgctgac tctggaggac ctgcatgctt tcttgagctg tgaacttcag tgctaaaagc   1920

tcataggcag ccctgaaacc caaaccaaaa ggttctatgg tttatcatcc cgatcatgtt   1980

gattttatag aaataacaca tgaattaaag acactaccct caaactgagc aaaacttaag   2040

taattttttt aaagtttgac ctgtttttaa atcactcttg gagaaaaagg aaaataaata   2100

caaataatta acggtgaata caggctacta tacctttgtt ctccagaatt agcagttctg   2160

ttcttttctt gctttagatg ctgaagtgca gaaggacact ctgtgattgt acgtgtgtaa   2220

ctgacaaaat gtgtattttt tttctcagct gctatggatt ggattatgct attatgaata   2280

agaatgctga tgggagcaca cacaaaccat ttgttcctca gtccattttc ctcctcaaaa   2340

gcctggaatg tgccattgat cagtgggaga tgtacctgga cagacccatg aaaagagatc   2400

aacaagttcc acccaaggga ccctattttt cctaatttca tttgaaatgg cttctaattg   2460

tccttctttc attcctgctt cctaccagtt ttacagcttt ttctggtttc aaatgtgaac   2520

tcacatacac tctcattttt cctcatcaca accccaagtg acccaatggt cctcactttc   2580

gatataagta aaggaggctc tgcattaagg gcttgtccaa ggcacgcagc tgagaggcgc   2640

taggactggc tccatttcca tctctattct cactgacttt gactacccag aaccccaaca   2700

tgtggggcct cagtattcga tcaattattc tattaagaag caaaaacaat tccccgcatt   2760

ggccccagtt attaagcatt tctcagattt accttgagaa atgcccatcg gcctgtatat   2820

tcacatcttc acccttgtcc cttcctccta gaaaggagaa agtcagttgg atgccctctg   2880

aggaactagt gcatggctta actgtccttc catgactcct gccttatctg ttttctattt   2940

tcctcctttt ccaccgaagt ctataatctc aagaaaagca ggcactggcc ttagggctcc   3000

tggcctaaga aatatcaagt ccagtgagaa atcccattga ctgacccctc ctgcttaccc   3060

ctttgtgatg gagaagctcc caggggtttg ctttttgcat gttaccaggc ctaactcagc   3120

atcaccaggg gcaagaaaag gaaagtaacc taaactaatg ctgcttataa ttgtaattat   3180

tgtaatagtt aattactgtg attgtacatg tgtaacagac aaaatgtgta tttttttcac   3240

agctgctgtg gattggatta tgccatttgg aataagaatg ctgttaagag cacacaagcc   3300

aggttcctca agtccgtagc aaatttttca aaagttaaat ttaaaaatca ctacatttga   3360

atctagtgac aggagaaatg gacatggata gagactaaag atctagccca aattttatat   3420

ttacttgtta gaggattttg aacaaattac taaatttctt caaggttcaa tttccccatt   3480

aactataatg aatggctcat cattatgggg ccctggagaa gcataattac ttgtaattgt   3540

aataatcatt gttattatta ttatacatat tttgctttta aatggataag gatttttaag   3600

gtatatgtaa actgtaaaac ataaaatgca aaatgccgta agagacagta gtaataataa   3660

tgattattat attgttatca ttatctagcc tgttttttcc tgttttgtat ttcttccttt   3720

aaatgctttc agaaatctgt atccccattc ttcaccacca ccccacaaca tttctgcttc   3780

ttttcccatg ccgggtcatg ctaactttga aagcttcagc tctttccttc ctcaatcctt   3840

ttcctggcac ctctgatatg ccttttgaaa ttcatgttaa agaatcccta ggctgctatc   3900

acatgtggca tctttgttga gtacatgaat aaatcaactg gtgtgtttta cgaaggatga   3960

ttatgcttca ttgtgggatt gtatttttct tcttctatca cagggagaag tgaa atg     4017
                                                            Met         
                                                            1           

aca acc tca cta gat aca gtt gag acc ttt ggt acc aca tcc tac tat     4065
Thr Thr Ser Leu Asp Thr Val Glu Thr Phe Gly Thr Thr Ser Tyr Tyr         
            5                   10                  15                  

gat gac gtg ggc ctg ctc tgt gaa aaa gct gat acc aga gca ctg atg     4113
Asp Asp Val Gly Leu Leu Cys Glu Lys Ala Asp Thr Arg Ala Leu Met         
        20                  25                  30                      

gcc cag ttt gtg ccc ccg ctg tac tcc ctg gtg ttc act gtg ggc ctc     4161
Ala Gln Phe Val Pro Pro Leu Tyr Ser Leu Val Phe Thr Val Gly Leu         
    35                  40                  45                          

ttg ggc aat gtg gtg gtg gtg atg atc ctc ata aaa tac agg agg ctc     4209
Leu Gly Asn Val Val Val Val Met Ile Leu Ile Lys Tyr Arg Arg Leu         
50                  55                  60                  65          

cga att atg acc aac atc tac ctg ctc aac ctg gcc att tcg gac ctg     4257
Arg Ile Met Thr Asn Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp Leu         
                70                  75                  80              

ctc ttc ctc gtc acc ctt cca ttc tgg atc cac tat gtc agg ggg cat     4305
Leu Phe Leu Val Thr Leu Pro Phe Trp Ile His Tyr Val Arg Gly His         
            85                  90                  95                  

aac tgg gtt ttt ggc cat ggc atg tgt aag ctc ctc tca ggg ttt tat     4353
Asn Trp Val Phe Gly His Gly Met Cys Lys Leu Leu Ser Gly Phe Tyr         
        100                 105                 110                     

cac aca ggc ttg tac agc gag atc ttt ttc ata atc ctg ctg aca atc     4401
His Thr Gly Leu Tyr Ser Glu Ile Phe Phe Ile Ile Leu Leu Thr Ile         
    115                 120                 125                         

gac agg tac ctg gcc att gtc cat gct gtg ttt gcc ctt cga gcc cgg     4449
Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe Ala Leu Arg Ala Arg         
130                 135                 140                 145         

act gtc act ttt ggt gtc atc acc agc atc gtc acc tgg ggc ctg gca     4497
Thr Val Thr Phe Gly Val Ile Thr Ser Ile Val Thr Trp Gly Leu Ala         
                150                 155                 160             

gtg cta gca gct ctt cct gaa ttt atc ttc tat gag act gaa gag ttg     4545
Val Leu Ala Ala Leu Pro Glu Phe Ile Phe Tyr Glu Thr Glu Glu Leu         
            165                 170                 175                 

ttt gaa gag act ctt tgc agt gct ctt tac cca gag gat aca gta tat     4593
Phe Glu Glu Thr Leu Cys Ser Ala Leu Tyr Pro Glu Asp Thr Val Tyr         
        180                 185                 190                     

agc tgg agg cat ttc cac act ctg aga atg acc atc ttc tgt ctc gtt     4641
Ser Trp Arg His Phe His Thr Leu Arg Met Thr Ile Phe Cys Leu Val         
    195                 200                 205                         

ctc cct ctg ctc gtt atg gcc atc tgc tac aca gga atc atc aaa acg     4689
Leu Pro Leu Leu Val Met Ala Ile Cys Tyr Thr Gly Ile Ile Lys Thr         
210                 215                 220                 225         

ctg ctg agg tgc ccc agt aaa aaa aag tac aag gcc atc cgg ctc att     4737
Leu Leu Arg Cys Pro Ser Lys Lys Lys Tyr Lys Ala Ile Arg Leu Ile         
                230                 235                 240             

ttt gtc atc atg gcg gtg ttt ttc att ttc tgg aca ccc tac aat gtg     4785
Phe Val Ile Met Ala Val Phe Phe Ile Phe Trp Thr Pro Tyr Asn Val         
            245                 250                 255                 

gct atc ctt ctc tct tcc tat caa tcc atc tta ttt gga aat gac tgt     4833
Ala Ile Leu Leu Ser Ser Tyr Gln Ser Ile Leu Phe Gly Asn Asp Cys         
        260                 265                 270                     

gag cgg agc aag cat ctg gac ctg gtc atg ctg gtg aca gag gtg atc     4881
Glu Arg Ser Lys His Leu Asp Leu Val Met Leu Val Thr Glu Val Ile         
    275                 280                 285                         

gcc tac tcc cac tgc tgc atg aac ccg gtg atc tac gcc ttt gtt gga     4929
Ala Tyr Ser His Cys Cys Met Asn Pro Val Ile Tyr Ala Phe Val Gly         
290                 295                 300                 305         

gag agg ttc cgg aag tac ctg cgc cac ttc ttc cac agg cac ttg ctc     4977
Glu Arg Phe Arg Lys Tyr Leu Arg His Phe Phe His Arg His Leu Leu         
                310                 315                 320             

atg cac ctg ggc aga tac atc cca ttc ctt cct agt gag aag ctg gaa     5025
Met His Leu Gly Arg Tyr Ile Pro Phe Leu Pro Ser Glu Lys Leu Glu         
            325                 330                 335                 

aga acc agc tct gtc tct cca tcc aca gca gag ccg gaa ctc tct att     5073
Arg Thr Ser Ser Val Ser Pro Ser Thr Ala Glu Pro Glu Leu Ser Ile         
        340                 345                 350                     

gtg ttt tag gtcagatgca gaaaattgcc taaagaggaa ggaccaagga             5122
Val Phe                                                                 
    355                                                                 

gatgaagcaa acacattaag ccttccacac tcacctct                           5160


<210>  6
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Thr Thr Ser Leu Asp Thr Val Glu Thr Phe Gly Thr Thr Ser Tyr 
1               5                   10                  15      


Tyr Asp Asp Val Gly Leu Leu Cys Glu Lys Ala Asp Thr Arg Ala Leu 
            20                  25                  30          


Met Ala Gln Phe Val Pro Pro Leu Tyr Ser Leu Val Phe Thr Val Gly 
        35                  40                  45              


Leu Leu Gly Asn Val Val Val Val Met Ile Leu Ile Lys Tyr Arg Arg 
    50                  55                  60                  


Leu Arg Ile Met Thr Asn Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp 
65                  70                  75                  80  


Leu Leu Phe Leu Val Thr Leu Pro Phe Trp Ile His Tyr Val Arg Gly 
                85                  90                  95      


His Asn Trp Val Phe Gly His Gly Met Cys Lys Leu Leu Ser Gly Phe 
            100                 105                 110         


Tyr His Thr Gly Leu Tyr Ser Glu Ile Phe Phe Ile Ile Leu Leu Thr 
        115                 120                 125             


Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe Ala Leu Arg Ala 
    130                 135                 140                 


Arg Thr Val Thr Phe Gly Val Ile Thr Ser Ile Val Thr Trp Gly Leu 
145                 150                 155                 160 


Ala Val Leu Ala Ala Leu Pro Glu Phe Ile Phe Tyr Glu Thr Glu Glu 
                165                 170                 175     


Leu Phe Glu Glu Thr Leu Cys Ser Ala Leu Tyr Pro Glu Asp Thr Val 
            180                 185                 190         


Tyr Ser Trp Arg His Phe His Thr Leu Arg Met Thr Ile Phe Cys Leu 
        195                 200                 205             


Val Leu Pro Leu Leu Val Met Ala Ile Cys Tyr Thr Gly Ile Ile Lys 
    210                 215                 220                 


Thr Leu Leu Arg Cys Pro Ser Lys Lys Lys Tyr Lys Ala Ile Arg Leu 
225                 230                 235                 240 


Ile Phe Val Ile Met Ala Val Phe Phe Ile Phe Trp Thr Pro Tyr Asn 
                245                 250                 255     


Val Ala Ile Leu Leu Ser Ser Tyr Gln Ser Ile Leu Phe Gly Asn Asp 
            260                 265                 270         


Cys Glu Arg Ser Lys His Leu Asp Leu Val Met Leu Val Thr Glu Val 
        275                 280                 285             


Ile Ala Tyr Ser His Cys Cys Met Asn Pro Val Ile Tyr Ala Phe Val 
    290                 295                 300                 


Gly Glu Arg Phe Arg Lys Tyr Leu Arg His Phe Phe His Arg His Leu 
305                 310                 315                 320 


Leu Met His Leu Gly Arg Tyr Ile Pro Phe Leu Pro Ser Glu Lys Leu 
                325                 330                 335     


Glu Arg Thr Ser Ser Val Ser Pro Ser Thr Ala Glu Pro Glu Leu Ser 
            340                 345                 350         


Ile Val Phe 
        355 


<210>  7
<211>  1680
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (361)..(1485)

<400>  7
agaaacagga gcagatgtac agggtttgcc tgactcacac tcaaggttgc ataagcaaga     60

tttcaaaatt aatcctattc tggagacctc aacccaatgt acaatgttcc tgactggaaa    120

agaagaacta tatttttctg attttttttt tcaaatcttt accattagtt gccctgtatc    180

tccgccttca ctttctgcag gaaactttat ttcctacttc tgcatgccaa gtttctacct    240

ctagatctgt ttggttcagt tgctgagaag cctgacatac caggactgcc tgagacaagc    300

cacaagctga acagagaaag tggattgaac aaggacgcat ttccccagta catccacaac    360

atg ctg tcc aca tct cgt tct cgg ttt atc aga aat acc aac gag agc      408
Met Leu Ser Thr Ser Arg Ser Arg Phe Ile Arg Asn Thr Asn Glu Ser         
1               5                   10                  15              

ggt gaa gaa gtc acc acc ttt ttt gat tat gat tac ggt gct ccc tgt      456
Gly Glu Glu Val Thr Thr Phe Phe Asp Tyr Asp Tyr Gly Ala Pro Cys         
            20                  25                  30                  

cat aaa ttt gac gtg aag caa att ggg gcc caa ctc ctg cct ccg ctc      504
His Lys Phe Asp Val Lys Gln Ile Gly Ala Gln Leu Leu Pro Pro Leu         
        35                  40                  45                      

tac tcg ctg gtg ttc atc ttt ggt ttt gtg ggc aac atg ctg gtc gtc      552
Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn Met Leu Val Val         
    50                  55                  60                          

ctc atc tta ata aac tgc aaa aag ctg aag tgc ttg act gac att tac      600
Leu Ile Leu Ile Asn Cys Lys Lys Leu Lys Cys Leu Thr Asp Ile Tyr         
65                  70                  75                  80          

ctg ctc aac ctg gcc atc tct gat ctg ctt ttt ctt att act ctc cca      648
Leu Leu Asn Leu Ala Ile Ser Asp Leu Leu Phe Leu Ile Thr Leu Pro         
                85                  90                  95              

ttg tgg gct cac tct gct gca aat gag tgg gtc ttt ggg aat gca atg      696
Leu Trp Ala His Ser Ala Ala Asn Glu Trp Val Phe Gly Asn Ala Met         
            100                 105                 110                 

tgc aaa tta ttc aca ggg ctg tat cac atc ggt tat ttt ggc gga atc      744
Cys Lys Leu Phe Thr Gly Leu Tyr His Ile Gly Tyr Phe Gly Gly Ile         
        115                 120                 125                     

ttc ttc atc atc ctc ctg aca atc gat aga tac ctg gct att gtc cat      792
Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu Ala Ile Val His         
    130                 135                 140                         

gct gtg ttt gct tta aaa gcc agg acg gtc acc ttt ggg gtg gtg aca      840
Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe Gly Val Val Thr         
145                 150                 155                 160         

agt gtg atc acc tgg ttg gtg gct gtg ttt gct tct gtc cca gga atc      888
Ser Val Ile Thr Trp Leu Val Ala Val Phe Ala Ser Val Pro Gly Ile         
                165                 170                 175             

atc ttt act aaa tgc cag aaa gaa gat tct gtt tat gtc tgt ggc cct      936
Ile Phe Thr Lys Cys Gln Lys Glu Asp Ser Val Tyr Val Cys Gly Pro         
            180                 185                 190                 

tat ttt cca cga gga tgg aat aat ttc cac aca ata atg agg aac att      984
Tyr Phe Pro Arg Gly Trp Asn Asn Phe His Thr Ile Met Arg Asn Ile         
        195                 200                 205                     

ttg ggg ctg gtc ctg ccg ctg ctc atc atg gtc atc tgc tac tcg gga     1032
Leu Gly Leu Val Leu Pro Leu Leu Ile Met Val Ile Cys Tyr Ser Gly         
    210                 215                 220                         

atc ctg aaa acc ctg ctt cgg tgt cga aac gag aag aag agg cat agg     1080
Ile Leu Lys Thr Leu Leu Arg Cys Arg Asn Glu Lys Lys Arg His Arg         
225                 230                 235                 240         

gca gtg aga gtc atc ttc acc atc atg att gtt tac ttt ctc ttc tgg     1128
Ala Val Arg Val Ile Phe Thr Ile Met Ile Val Tyr Phe Leu Phe Trp         
                245                 250                 255             

act ccc tat aat att gtc att ctc ctg aac acc ttc cag gaa ttc ttc     1176
Thr Pro Tyr Asn Ile Val Ile Leu Leu Asn Thr Phe Gln Glu Phe Phe         
            260                 265                 270                 

ggc ctg agt aac tgt gaa agc acc agt caa ctg gac caa gcc acg cag     1224
Gly Leu Ser Asn Cys Glu Ser Thr Ser Gln Leu Asp Gln Ala Thr Gln         
        275                 280                 285                     

gtg aca gag act ctt ggg atg act cac tgc tgc atc aat ccc atc atc     1272
Val Thr Glu Thr Leu Gly Met Thr His Cys Cys Ile Asn Pro Ile Ile         
    290                 295                 300                         

tat gcc ttc gtt ggg gag aag ttc aga agc ctt ttt cac ata gct ctt     1320
Tyr Ala Phe Val Gly Glu Lys Phe Arg Ser Leu Phe His Ile Ala Leu         
305                 310                 315                 320         

ggc tgt agg att gcc cca ctc caa aaa cca gtg tgt gga ggt cca gga     1368
Gly Cys Arg Ile Ala Pro Leu Gln Lys Pro Val Cys Gly Gly Pro Gly         
                325                 330                 335             

gtg aga cca gga aag aat gtg aaa gtg act aca caa gga ctc ctc gat     1416
Val Arg Pro Gly Lys Asn Val Lys Val Thr Thr Gln Gly Leu Leu Asp         
            340                 345                 350                 

ggt cgt gga aaa gga aag tca att ggc aga gcc cct gaa gcc agt ctt     1464
Gly Arg Gly Lys Gly Lys Ser Ile Gly Arg Ala Pro Glu Ala Ser Leu         
        355                 360                 365                     

cag gac aaa gaa gga gcc tag agacagaaat gacagatctc tgctttggaa        1515
Gln Asp Lys Glu Gly Ala                                                 
    370                                                                 

atcacacgtc tggcttcaca gatgtgtgat tcacagtgtg aatcttggtg tctacgttac   1575

caggcaggaa ggctgagagg agagagactc cagctgggtt ggaaaacagt attttccaaa   1635

ctaccttcca gttcctcatt tttgaataca ggcatagagt tcaga                   1680


<210>  8
<211>  374
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Leu Ser Thr Ser Arg Ser Arg Phe Ile Arg Asn Thr Asn Glu Ser 
1               5                   10                  15      


Gly Glu Glu Val Thr Thr Phe Phe Asp Tyr Asp Tyr Gly Ala Pro Cys 
            20                  25                  30          


His Lys Phe Asp Val Lys Gln Ile Gly Ala Gln Leu Leu Pro Pro Leu 
        35                  40                  45              


Tyr Ser Leu Val Phe Ile Phe Gly Phe Val Gly Asn Met Leu Val Val 
    50                  55                  60                  


Leu Ile Leu Ile Asn Cys Lys Lys Leu Lys Cys Leu Thr Asp Ile Tyr 
65                  70                  75                  80  


Leu Leu Asn Leu Ala Ile Ser Asp Leu Leu Phe Leu Ile Thr Leu Pro 
                85                  90                  95      


Leu Trp Ala His Ser Ala Ala Asn Glu Trp Val Phe Gly Asn Ala Met 
            100                 105                 110         


Cys Lys Leu Phe Thr Gly Leu Tyr His Ile Gly Tyr Phe Gly Gly Ile 
        115                 120                 125             


Phe Phe Ile Ile Leu Leu Thr Ile Asp Arg Tyr Leu Ala Ile Val His 
    130                 135                 140                 


Ala Val Phe Ala Leu Lys Ala Arg Thr Val Thr Phe Gly Val Val Thr 
145                 150                 155                 160 


Ser Val Ile Thr Trp Leu Val Ala Val Phe Ala Ser Val Pro Gly Ile 
                165                 170                 175     


Ile Phe Thr Lys Cys Gln Lys Glu Asp Ser Val Tyr Val Cys Gly Pro 
            180                 185                 190         


Tyr Phe Pro Arg Gly Trp Asn Asn Phe His Thr Ile Met Arg Asn Ile 
        195                 200                 205             


Leu Gly Leu Val Leu Pro Leu Leu Ile Met Val Ile Cys Tyr Ser Gly 
    210                 215                 220                 


Ile Leu Lys Thr Leu Leu Arg Cys Arg Asn Glu Lys Lys Arg His Arg 
225                 230                 235                 240 


Ala Val Arg Val Ile Phe Thr Ile Met Ile Val Tyr Phe Leu Phe Trp 
                245                 250                 255     


Thr Pro Tyr Asn Ile Val Ile Leu Leu Asn Thr Phe Gln Glu Phe Phe 
            260                 265                 270         


Gly Leu Ser Asn Cys Glu Ser Thr Ser Gln Leu Asp Gln Ala Thr Gln 
        275                 280                 285             


Val Thr Glu Thr Leu Gly Met Thr His Cys Cys Ile Asn Pro Ile Ile 
    290                 295                 300                 


Tyr Ala Phe Val Gly Glu Lys Phe Arg Ser Leu Phe His Ile Ala Leu 
305                 310                 315                 320 


Gly Cys Arg Ile Ala Pro Leu Gln Lys Pro Val Cys Gly Gly Pro Gly 
                325                 330                 335     


Val Arg Pro Gly Lys Asn Val Lys Val Thr Thr Gln Gly Leu Leu Asp 
            340                 345                 350         


Gly Arg Gly Lys Gly Lys Ser Ile Gly Arg Ala Pro Glu Ala Ser Leu 
        355                 360                 365             


Gln Asp Lys Glu Gly Ala 
    370                 


<210>  9
<211>  1260
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (72)..(1139)

<400>  9
ataaaaaccc agaaagcccc agaaacaaag acttcacgga caaagtccct tggaaccaga     60

gagaagccgg g atg gaa act cca aac acc aca gag gac tat gac acg acc     110
             Met Glu Thr Pro Asn Thr Thr Glu Asp Tyr Asp Thr Thr        
             1               5                   10                     

aca gag ttt gac tat ggg gat gca act ccg tgc cag aag gtg aac gag      158
Thr Glu Phe Asp Tyr Gly Asp Ala Thr Pro Cys Gln Lys Val Asn Glu         
    15                  20                  25                          

agg gcc ttt ggg gcc caa ctg ctg ccc cct ctg tac tcc ttg gta ttt      206
Arg Ala Phe Gly Ala Gln Leu Leu Pro Pro Leu Tyr Ser Leu Val Phe         
30                  35                  40                  45          

gtc att ggc ctg gtt gga aac atc ctg gtg gtc ctg gtc ctt gtg caa      254
Val Ile Gly Leu Val Gly Asn Ile Leu Val Val Leu Val Leu Val Gln         
                50                  55                  60              

tac aag agg cta aaa aac atg acc agc atc tac ctc ctg aac ctg gcc      302
Tyr Lys Arg Leu Lys Asn Met Thr Ser Ile Tyr Leu Leu Asn Leu Ala         
            65                  70                  75                  

att tct gac ctg ctc ttc ctg ttc acg ctt ccc ttc tgg atc gac tac      350
Ile Ser Asp Leu Leu Phe Leu Phe Thr Leu Pro Phe Trp Ile Asp Tyr         
        80                  85                  90                      

aag ttg aag gat gac tgg gtt ttt ggt gat gcc atg tgt aag atc ctc      398
Lys Leu Lys Asp Asp Trp Val Phe Gly Asp Ala Met Cys Lys Ile Leu         
    95                  100                 105                         

tct ggg ttt tat tac aca ggc ttg tac agc gag atc ttt ttc atc atc      446
Ser Gly Phe Tyr Tyr Thr Gly Leu Tyr Ser Glu Ile Phe Phe Ile Ile         
110                 115                 120                 125         

ctg ctg acg att gac agg tac ctg gcc atc gtc cac gcc gtg ttt gcc      494
Leu Leu Thr Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe Ala         
                130                 135                 140             

ttg cgg gca cgg acc gtc act ttt ggt gtc atc acc agc atc atc att      542
Leu Arg Ala Arg Thr Val Thr Phe Gly Val Ile Thr Ser Ile Ile Ile         
            145                 150                 155                 

tgg gcc ctg gcc atc ttg gct tcc atg cca ggc tta tac ttt tcc aag      590
Trp Ala Leu Ala Ile Leu Ala Ser Met Pro Gly Leu Tyr Phe Ser Lys         
        160                 165                 170                     

acc caa tgg gaa ttc act cac cac acc tgc agc ctt cac ttt cct cac      638
Thr Gln Trp Glu Phe Thr His His Thr Cys Ser Leu His Phe Pro His         
    175                 180                 185                         

gaa agc cta cga gag tgg aag ctg ttt cag gct ctg aaa ctg aac ctc      686
Glu Ser Leu Arg Glu Trp Lys Leu Phe Gln Ala Leu Lys Leu Asn Leu         
190                 195                 200                 205         

ttt ggg ctg gta ttg cct ttg ttg gtc atg atc atc tgc tac aca ggg      734
Phe Gly Leu Val Leu Pro Leu Leu Val Met Ile Ile Cys Tyr Thr Gly         
                210                 215                 220             

att ata aag att ctg cta aga cga cca aat gag aag aaa tcc aaa gct      782
Ile Ile Lys Ile Leu Leu Arg Arg Pro Asn Glu Lys Lys Ser Lys Ala         
            225                 230                 235                 

gtc cgt ttg att ttt gtc atc atg atc atc ttt ttt ctc ttt tgg acc      830
Val Arg Leu Ile Phe Val Ile Met Ile Ile Phe Phe Leu Phe Trp Thr         
        240                 245                 250                     

ccc tac aat ttg act ata ctt att tct gtt ttc caa gac ttc ctg ttc      878
Pro Tyr Asn Leu Thr Ile Leu Ile Ser Val Phe Gln Asp Phe Leu Phe         
    255                 260                 265                         

acc cat gag tgt gag cag agc aga cat ttg gac ctg gct gtg caa gtg      926
Thr His Glu Cys Glu Gln Ser Arg His Leu Asp Leu Ala Val Gln Val         
270                 275                 280                 285         

acg gag gtg atc gcc tac acg cac tgc tgt gtc aac cca gtg atc tac      974
Thr Glu Val Ile Ala Tyr Thr His Cys Cys Val Asn Pro Val Ile Tyr         
                290                 295                 300             

gcc ttc gtt ggt gag agg ttc cgg aag tac ctg cgg cag ttg ttc cac     1022
Ala Phe Val Gly Glu Arg Phe Arg Lys Tyr Leu Arg Gln Leu Phe His         
            305                 310                 315                 

agg cgt gtg gct gtg cac ctg gtt aaa tgg ctc ccc ttc ctc tcc gtg     1070
Arg Arg Val Ala Val His Leu Val Lys Trp Leu Pro Phe Leu Ser Val         
        320                 325                 330                     

gac agg ctg gag agg gtc agc tcc aca tct ccc tcc aca ggg gag cat     1118
Asp Arg Leu Glu Arg Val Ser Ser Thr Ser Pro Ser Thr Gly Glu His         
    335                 340                 345                         

gaa ctc tct gct ggg ttc tga ctcagaccat aggaggccaa cccaaaataa        1169
Glu Leu Ser Ala Gly Phe                                                 
350                 355                                                 

gcaggcgtga cctgccaggc acactgagcc agcagcctgg ctctcccagc caggttctga   1229

ctcttggcac agcatggagt cacagccact t                                  1260


<210>  10
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Glu Thr Pro Asn Thr Thr Glu Asp Tyr Asp Thr Thr Thr Glu Phe 
1               5                   10                  15      


Asp Tyr Gly Asp Ala Thr Pro Cys Gln Lys Val Asn Glu Arg Ala Phe 
            20                  25                  30          


Gly Ala Gln Leu Leu Pro Pro Leu Tyr Ser Leu Val Phe Val Ile Gly 
        35                  40                  45              


Leu Val Gly Asn Ile Leu Val Val Leu Val Leu Val Gln Tyr Lys Arg 
    50                  55                  60                  


Leu Lys Asn Met Thr Ser Ile Tyr Leu Leu Asn Leu Ala Ile Ser Asp 
65                  70                  75                  80  


Leu Leu Phe Leu Phe Thr Leu Pro Phe Trp Ile Asp Tyr Lys Leu Lys 
                85                  90                  95      


Asp Asp Trp Val Phe Gly Asp Ala Met Cys Lys Ile Leu Ser Gly Phe 
            100                 105                 110         


Tyr Tyr Thr Gly Leu Tyr Ser Glu Ile Phe Phe Ile Ile Leu Leu Thr 
        115                 120                 125             


Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe Ala Leu Arg Ala 
    130                 135                 140                 


Arg Thr Val Thr Phe Gly Val Ile Thr Ser Ile Ile Ile Trp Ala Leu 
145                 150                 155                 160 


Ala Ile Leu Ala Ser Met Pro Gly Leu Tyr Phe Ser Lys Thr Gln Trp 
                165                 170                 175     


Glu Phe Thr His His Thr Cys Ser Leu His Phe Pro His Glu Ser Leu 
            180                 185                 190         


Arg Glu Trp Lys Leu Phe Gln Ala Leu Lys Leu Asn Leu Phe Gly Leu 
        195                 200                 205             


Val Leu Pro Leu Leu Val Met Ile Ile Cys Tyr Thr Gly Ile Ile Lys 
    210                 215                 220                 


Ile Leu Leu Arg Arg Pro Asn Glu Lys Lys Ser Lys Ala Val Arg Leu 
225                 230                 235                 240 


Ile Phe Val Ile Met Ile Ile Phe Phe Leu Phe Trp Thr Pro Tyr Asn 
                245                 250                 255     


Leu Thr Ile Leu Ile Ser Val Phe Gln Asp Phe Leu Phe Thr His Glu 
            260                 265                 270         


Cys Glu Gln Ser Arg His Leu Asp Leu Ala Val Gln Val Thr Glu Val 
        275                 280                 285             


Ile Ala Tyr Thr His Cys Cys Val Asn Pro Val Ile Tyr Ala Phe Val 
    290                 295                 300                 


Gly Glu Arg Phe Arg Lys Tyr Leu Arg Gln Leu Phe His Arg Arg Val 
305                 310                 315                 320 


Ala Val His Leu Val Lys Trp Leu Pro Phe Leu Ser Val Asp Arg Leu 
                325                 330                 335     


Glu Arg Val Ser Ser Thr Ser Pro Ser Thr Gly Glu His Glu Leu Ser 
            340                 345                 350         


Ala Gly Phe 
        355 


<210>  11
<211>  1380
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (183)..(1265)

<400>  11
cgggggtttt gatcttcttc cccttctttt cttccccttc ttctttcctt cctccctccc     60

tctctcattt cccttctcct tctccctcag tctccacatt caacattgac aagtccattc    120

agaaaagcaa gctgcttctg gttgggccca gacctgcctt gaggagcctg tagagttaaa    180

aa atg aac ccc acg gat ata gca gat acc acc ctc gat gaa agc ata       227
   Met Asn Pro Thr Asp Ile Ala Asp Thr Thr Leu Asp Glu Ser Ile          
   1               5                   10                  15           

tac agc aat tac tat ctg tat gaa agt atc ccc aag cct tgc acc aaa      275
Tyr Ser Asn Tyr Tyr Leu Tyr Glu Ser Ile Pro Lys Pro Cys Thr Lys         
                20                  25                  30              

gaa ggc atc aag gca ttt ggg gag ctc ttc ctg ccc cca ctg tat tcc      323
Glu Gly Ile Lys Ala Phe Gly Glu Leu Phe Leu Pro Pro Leu Tyr Ser         
            35                  40                  45                  

ttg gtt ttt gta ttt ggt ctg ctt gga aat tct gtg gtg gtt ctg gtc      371
Leu Val Phe Val Phe Gly Leu Leu Gly Asn Ser Val Val Val Leu Val         
        50                  55                  60                      

ctg ttc aaa tac aag cgg ctc agg tcc atg act gat gtg tac ctg ctc      419
Leu Phe Lys Tyr Lys Arg Leu Arg Ser Met Thr Asp Val Tyr Leu Leu         
    65                  70                  75                          

aac ctt gcc atc tcg gat ctg ctc ttc gtg ttt tcc ctc cct ttt tgg      467
Asn Leu Ala Ile Ser Asp Leu Leu Phe Val Phe Ser Leu Pro Phe Trp         
80                  85                  90                  95          

ggc tac tat gca gca gac cag tgg gtt ttt ggg cta ggt ctg tgc aag      515
Gly Tyr Tyr Ala Ala Asp Gln Trp Val Phe Gly Leu Gly Leu Cys Lys         
                100                 105                 110             

atg att tcc tgg atg tac ttg gtg ggc ttt tac agt ggc ata ttc ttt      563
Met Ile Ser Trp Met Tyr Leu Val Gly Phe Tyr Ser Gly Ile Phe Phe         
            115                 120                 125                 

gtc atg ctc atg agc att gat aga tac ctg gcg ata gtg cac gcg gtg      611
Val Met Leu Met Ser Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val         
        130                 135                 140                     

ttt tcc ttg agg gca agg acc ttg act tat ggg gtc atc acc agt ttg      659
Phe Ser Leu Arg Ala Arg Thr Leu Thr Tyr Gly Val Ile Thr Ser Leu         
    145                 150                 155                         

gct aca tgg tca gtg gct gtg ttc gcc tcc ctt cct ggc ttt ctg ttc      707
Ala Thr Trp Ser Val Ala Val Phe Ala Ser Leu Pro Gly Phe Leu Phe         
160                 165                 170                 175         

agc act tgt tat act gag cgc aac cat acc tac tgc aaa acc aag tac      755
Ser Thr Cys Tyr Thr Glu Arg Asn His Thr Tyr Cys Lys Thr Lys Tyr         
                180                 185                 190             

tct ctc aac tcc acg acg tgg aag gtt ctc agc tcc ctg gaa atc aac      803
Ser Leu Asn Ser Thr Thr Trp Lys Val Leu Ser Ser Leu Glu Ile Asn         
            195                 200                 205                 

att ctc gga ttg gtg atc ccc tta ggg atc atg ctg ttt tgc tac tcc      851
Ile Leu Gly Leu Val Ile Pro Leu Gly Ile Met Leu Phe Cys Tyr Ser         
        210                 215                 220                     

atg atc atc agg acc ttg cag cat tgt aaa aat gag aag aag aac aag      899
Met Ile Ile Arg Thr Leu Gln His Cys Lys Asn Glu Lys Lys Asn Lys         
    225                 230                 235                         

gcg gtg aag atg atc ttt gcc gtg gtg gtc ctc ttc ctt ggg ttc tgg      947
Ala Val Lys Met Ile Phe Ala Val Val Val Leu Phe Leu Gly Phe Trp         
240                 245                 250                 255         

aca cct tac aac ata gtg ctc ttc cta gag acc ctg gtg gag cta gaa      995
Thr Pro Tyr Asn Ile Val Leu Phe Leu Glu Thr Leu Val Glu Leu Glu         
                260                 265                 270             

gtc ctt cag gac tgc acc ttt gaa aga tac ttg gac tat gcc atc cag     1043
Val Leu Gln Asp Cys Thr Phe Glu Arg Tyr Leu Asp Tyr Ala Ile Gln         
            275                 280                 285                 

gcc aca gaa act ctg gct ttt gtt cac tgc tgc ctt aat ccc atc atc     1091
Ala Thr Glu Thr Leu Ala Phe Val His Cys Cys Leu Asn Pro Ile Ile         
        290                 295                 300                     

tac ttt ttt ctg ggg gag aaa ttt cgc aag tac atc cta cag ctc ttc     1139
Tyr Phe Phe Leu Gly Glu Lys Phe Arg Lys Tyr Ile Leu Gln Leu Phe         
    305                 310                 315                         

aaa acc tgc agg ggc ctt ttt gtg ctc tgc caa tac tgt ggg ctc ctc     1187
Lys Thr Cys Arg Gly Leu Phe Val Leu Cys Gln Tyr Cys Gly Leu Leu         
320                 325                 330                 335         

caa att tac tct gct gac acc ccc agc tca tct tac acg cag tcc acc     1235
Gln Ile Tyr Ser Ala Asp Thr Pro Ser Ser Ser Tyr Thr Gln Ser Thr         
                340                 345                 350             

atg gat cat gat ctt cat gat gct ctg tag gaaaaatgaa atggtgaaat       1285
Met Asp His Asp Leu His Asp Ala Leu                                     
            355                 360                                     

gcagagtcaa tgaacttttc cacattcaga gcttacttta aaattggtat ttttaggtaa   1345

gagatccctg agccagtgtc aggaggaagg cttac                              1380


<210>  12
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asn Pro Thr Asp Ile Ala Asp Thr Thr Leu Asp Glu Ser Ile Tyr 
1               5                   10                  15      


Ser Asn Tyr Tyr Leu Tyr Glu Ser Ile Pro Lys Pro Cys Thr Lys Glu 
            20                  25                  30          


Gly Ile Lys Ala Phe Gly Glu Leu Phe Leu Pro Pro Leu Tyr Ser Leu 
        35                  40                  45              


Val Phe Val Phe Gly Leu Leu Gly Asn Ser Val Val Val Leu Val Leu 
    50                  55                  60                  


Phe Lys Tyr Lys Arg Leu Arg Ser Met Thr Asp Val Tyr Leu Leu Asn 
65                  70                  75                  80  


Leu Ala Ile Ser Asp Leu Leu Phe Val Phe Ser Leu Pro Phe Trp Gly 
                85                  90                  95      


Tyr Tyr Ala Ala Asp Gln Trp Val Phe Gly Leu Gly Leu Cys Lys Met 
            100                 105                 110         


Ile Ser Trp Met Tyr Leu Val Gly Phe Tyr Ser Gly Ile Phe Phe Val 
        115                 120                 125             


Met Leu Met Ser Ile Asp Arg Tyr Leu Ala Ile Val His Ala Val Phe 
    130                 135                 140                 


Ser Leu Arg Ala Arg Thr Leu Thr Tyr Gly Val Ile Thr Ser Leu Ala 
145                 150                 155                 160 


Thr Trp Ser Val Ala Val Phe Ala Ser Leu Pro Gly Phe Leu Phe Ser 
                165                 170                 175     


Thr Cys Tyr Thr Glu Arg Asn His Thr Tyr Cys Lys Thr Lys Tyr Ser 
            180                 185                 190         


Leu Asn Ser Thr Thr Trp Lys Val Leu Ser Ser Leu Glu Ile Asn Ile 
        195                 200                 205             


Leu Gly Leu Val Ile Pro Leu Gly Ile Met Leu Phe Cys Tyr Ser Met 
    210                 215                 220                 


Ile Ile Arg Thr Leu Gln His Cys Lys Asn Glu Lys Lys Asn Lys Ala 
225                 230                 235                 240 


Val Lys Met Ile Phe Ala Val Val Val Leu Phe Leu Gly Phe Trp Thr 
                245                 250                 255     


Pro Tyr Asn Ile Val Leu Phe Leu Glu Thr Leu Val Glu Leu Glu Val 
            260                 265                 270         


Leu Gln Asp Cys Thr Phe Glu Arg Tyr Leu Asp Tyr Ala Ile Gln Ala 
        275                 280                 285             


Thr Glu Thr Leu Ala Phe Val His Cys Cys Leu Asn Pro Ile Ile Tyr 
    290                 295                 300                 


Phe Phe Leu Gly Glu Lys Phe Arg Lys Tyr Ile Leu Gln Leu Phe Lys 
305                 310                 315                 320 


Thr Cys Arg Gly Leu Phe Val Leu Cys Gln Tyr Cys Gly Leu Leu Gln 
                325                 330                 335     


Ile Tyr Ser Ala Asp Thr Pro Ser Ser Ser Tyr Thr Gln Ser Thr Met 
            340                 345                 350         


Asp His Asp Leu His Asp Ala Leu 
        355                 360 


<210>  13
<211>  1320
<212>  DNA
<213>  Homo spaiens


<220>
<221>  CDS
<222>  (139)..(1206)

<400>  13
tttgtagtgg gaggatacct ccagagaggc tgctgctcat tgagctgcac tcacatgagg     60

atacagactt tgtgaagaag gaattggcaa cactgaaacc tccagaacaa aggctgtcac    120

taaggtcccg ctgccttg atg gat tat aca ctt gac ctc agt gtg aca aca      171
                    Met Asp Tyr Thr Leu Asp Leu Ser Val Thr Thr         
                    1               5                   10              

gtg acc gac tac tac tac cct gat atc ttc tca agc ccc tgt gat gcg      219
Val Thr Asp Tyr Tyr Tyr Pro Asp Ile Phe Ser Ser Pro Cys Asp Ala         
            15                  20                  25                  

gaa ctt att cag aca aat ggc aag ttg ctc ctt gct gtc ttt tat tgc      267
Glu Leu Ile Gln Thr Asn Gly Lys Leu Leu Leu Ala Val Phe Tyr Cys         
        30                  35                  40                      

ctc ctg ttt gta ttc agt ctt ctg gga aac agc ctg gtc atc ctg gtc      315
Leu Leu Phe Val Phe Ser Leu Leu Gly Asn Ser Leu Val Ile Leu Val         
    45                  50                  55                          

ctt gtg gtc tgc aag aag ctg agg agc atc aca gat gta tac ctc ttg      363
Leu Val Val Cys Lys Lys Leu Arg Ser Ile Thr Asp Val Tyr Leu Leu         
60                  65                  70                  75          

aac ctg gcc ctg tct gac ctg ctt ttt gtc ttc tcc ttc ccc ttt cag      411
Asn Leu Ala Leu Ser Asp Leu Leu Phe Val Phe Ser Phe Pro Phe Gln         
                80                  85                  90              

acc tac tat ctg ctg gac cag tgg gtg ttt ggg act gta atg tgc aaa      459
Thr Tyr Tyr Leu Leu Asp Gln Trp Val Phe Gly Thr Val Met Cys Lys         
            95                  100                 105                 

gtg gtg tct ggc ttt tat tac att ggc ttc tac agc agc atg ttt ttc      507
Val Val Ser Gly Phe Tyr Tyr Ile Gly Phe Tyr Ser Ser Met Phe Phe         
        110                 115                 120                     

atc acc ctc atg agt gtg gac agg tac ctg gct gtt gtc cat gcc gtg      555
Ile Thr Leu Met Ser Val Asp Arg Tyr Leu Ala Val Val His Ala Val         
    125                 130                 135                         

tat gcc cta aag gtg agg acg atc agg atg ggc aca acg ctg tgc ctg      603
Tyr Ala Leu Lys Val Arg Thr Ile Arg Met Gly Thr Thr Leu Cys Leu         
140                 145                 150                 155         

gca gta tgg cta acc gcc att atg gct acc atc cca ttg cta gtg ttt      651
Ala Val Trp Leu Thr Ala Ile Met Ala Thr Ile Pro Leu Leu Val Phe         
                160                 165                 170             

tac caa gtg gcc tct gaa gat ggt gtt cta cag tgt tat tca ttt tac      699
Tyr Gln Val Ala Ser Glu Asp Gly Val Leu Gln Cys Tyr Ser Phe Tyr         
            175                 180                 185                 

aat caa cag act ttg aag tgg aag atc ttc acc aac ttc aaa atg aac      747
Asn Gln Gln Thr Leu Lys Trp Lys Ile Phe Thr Asn Phe Lys Met Asn         
        190                 195                 200                     

att tta ggc ttg ttg atc cca ttc acc atc ttt atg ttc tgc tac att      795
Ile Leu Gly Leu Leu Ile Pro Phe Thr Ile Phe Met Phe Cys Tyr Ile         
    205                 210                 215                         

aaa atc ctg cac cag ctg aag agg tgt caa aac cac aac aag acc aag      843
Lys Ile Leu His Gln Leu Lys Arg Cys Gln Asn His Asn Lys Thr Lys         
220                 225                 230                 235         

gcc atc agg ttg gtg ctc att gtg gtc att gca tct tta ctt ttc tgg      891
Ala Ile Arg Leu Val Leu Ile Val Val Ile Ala Ser Leu Leu Phe Trp         
                240                 245                 250             

gtc cca ttc aac gtg gtt ctt ttc ctc act tcc ttg cac agt atg cac      939
Val Pro Phe Asn Val Val Leu Phe Leu Thr Ser Leu His Ser Met His         
            255                 260                 265                 

atc ttg gat gga tgt agc ata agc caa cag ctg act tat gcc acc cat      987
Ile Leu Asp Gly Cys Ser Ile Ser Gln Gln Leu Thr Tyr Ala Thr His         
        270                 275                 280                     

gtc aca gaa atc att tcc ttt act cac tgc tgt gtg aac cct gtt atc     1035
Val Thr Glu Ile Ile Ser Phe Thr His Cys Cys Val Asn Pro Val Ile         
    285                 290                 295                         

tat gct ttt gtt ggg gag aag ttc aag aaa cac ctc tca gaa ata ttt     1083
Tyr Ala Phe Val Gly Glu Lys Phe Lys Lys His Leu Ser Glu Ile Phe         
300                 305                 310                 315         

cag aaa agt tgc agc caa atc ttc aac tac cta gga aga caa atg cct     1131
Gln Lys Ser Cys Ser Gln Ile Phe Asn Tyr Leu Gly Arg Gln Met Pro         
                320                 325                 330             

agg gag agc tgt gaa aag tca tca tcc tgc cag cag cac tcc tcc cgt     1179
Arg Glu Ser Cys Glu Lys Ser Ser Ser Cys Gln Gln His Ser Ser Arg         
            335                 340                 345                 

tcc tcc agc gta gac tac att ttg tga ggatcaatga agactaaata           1226
Ser Ser Ser Val Asp Tyr Ile Leu                                         
        350                 355                                         

taaaaaacat tttcttgaat ggcatgctag tagcagtgag caaaggtgtg ggtgtgaaag   1286

gtttccaaaa aaagttcagc atgaaggatg ccat                               1320


<210>  14
<211>  355
<212>  PRT
<213>  Homo spaiens

<400>  14

Met Asp Tyr Thr Leu Asp Leu Ser Val Thr Thr Val Thr Asp Tyr Tyr 
1               5                   10                  15      


Tyr Pro Asp Ile Phe Ser Ser Pro Cys Asp Ala Glu Leu Ile Gln Thr 
            20                  25                  30          


Asn Gly Lys Leu Leu Leu Ala Val Phe Tyr Cys Leu Leu Phe Val Phe 
        35                  40                  45              


Ser Leu Leu Gly Asn Ser Leu Val Ile Leu Val Leu Val Val Cys Lys 
    50                  55                  60                  


Lys Leu Arg Ser Ile Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ser 
65                  70                  75                  80  


Asp Leu Leu Phe Val Phe Ser Phe Pro Phe Gln Thr Tyr Tyr Leu Leu 
                85                  90                  95      


Asp Gln Trp Val Phe Gly Thr Val Met Cys Lys Val Val Ser Gly Phe 
            100                 105                 110         


Tyr Tyr Ile Gly Phe Tyr Ser Ser Met Phe Phe Ile Thr Leu Met Ser 
        115                 120                 125             


Val Asp Arg Tyr Leu Ala Val Val His Ala Val Tyr Ala Leu Lys Val 
    130                 135                 140                 


Arg Thr Ile Arg Met Gly Thr Thr Leu Cys Leu Ala Val Trp Leu Thr 
145                 150                 155                 160 


Ala Ile Met Ala Thr Ile Pro Leu Leu Val Phe Tyr Gln Val Ala Ser 
                165                 170                 175     


Glu Asp Gly Val Leu Gln Cys Tyr Ser Phe Tyr Asn Gln Gln Thr Leu 
            180                 185                 190         


Lys Trp Lys Ile Phe Thr Asn Phe Lys Met Asn Ile Leu Gly Leu Leu 
        195                 200                 205             


Ile Pro Phe Thr Ile Phe Met Phe Cys Tyr Ile Lys Ile Leu His Gln 
    210                 215                 220                 


Leu Lys Arg Cys Gln Asn His Asn Lys Thr Lys Ala Ile Arg Leu Val 
225                 230                 235                 240 


Leu Ile Val Val Ile Ala Ser Leu Leu Phe Trp Val Pro Phe Asn Val 
                245                 250                 255     


Val Leu Phe Leu Thr Ser Leu His Ser Met His Ile Leu Asp Gly Cys 
            260                 265                 270         


Ser Ile Ser Gln Gln Leu Thr Tyr Ala Thr His Val Thr Glu Ile Ile 
        275                 280                 285             


Ser Phe Thr His Cys Cys Val Asn Pro Val Ile Tyr Ala Phe Val Gly 
    290                 295                 300                 


Glu Lys Phe Lys Lys His Leu Ser Glu Ile Phe Gln Lys Ser Cys Ser 
305                 310                 315                 320 


Gln Ile Phe Asn Tyr Leu Gly Arg Gln Met Pro Arg Glu Ser Cys Glu 
                325                 330                 335     


Lys Ser Ser Ser Cys Gln Gln His Ser Ser Arg Ser Ser Ser Val Asp 
            340                 345                 350         


Tyr Ile Leu 
        355 


<210>  15
<211>  1186
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (60)..(1169)

<400>  15
tgtcccaggg agagttgcat cgccctccac agagcaggct tgcatctgac tgacccacc      59

atg aca ccc aca gac ttc aca agc cct att cct aac atg gct gat gac      107
Met Thr Pro Thr Asp Phe Thr Ser Pro Ile Pro Asn Met Ala Asp Asp         
1               5                   10                  15              

tat ggc tct gaa tcc aca tct tcc atg gaa gac tac gtt aac ttc aac      155
Tyr Gly Ser Glu Ser Thr Ser Ser Met Glu Asp Tyr Val Asn Phe Asn         
            20                  25                  30                  

ttc act gac ttc tac tgt gag aaa aac aat gtc agg cag ttt gcg agc      203
Phe Thr Asp Phe Tyr Cys Glu Lys Asn Asn Val Arg Gln Phe Ala Ser         
        35                  40                  45                      

cat ttc ctc cca ccc ttg tac tgg ctc gtg ttc atc gtg ggt gcc ttg      251
His Phe Leu Pro Pro Leu Tyr Trp Leu Val Phe Ile Val Gly Ala Leu         
    50                  55                  60                          

ggc aac agt ctt gtt atc ctt gtc tac tgg tac tgc aca aga gtg aag      299
Gly Asn Ser Leu Val Ile Leu Val Tyr Trp Tyr Cys Thr Arg Val Lys         
65                  70                  75                  80          

acc atg acc gac atg ttc ctt ttg aat ttg gca att gct gac ctc ctc      347
Thr Met Thr Asp Met Phe Leu Leu Asn Leu Ala Ile Ala Asp Leu Leu         
                85                  90                  95              

ttt ctt gtc act ctt ccc ttc tgg gcc att gct gct gct gac cag tgg      395
Phe Leu Val Thr Leu Pro Phe Trp Ala Ile Ala Ala Ala Asp Gln Trp         
            100                 105                 110                 

aag ttc cag acc ttc atg tgc aag gtg gtc aac agc atg tac aag atg      443
Lys Phe Gln Thr Phe Met Cys Lys Val Val Asn Ser Met Tyr Lys Met         
        115                 120                 125                     

aac ttc tac agc tgt gtg ttg ctg atc atg tgc atc agc gtg gac agg      491
Asn Phe Tyr Ser Cys Val Leu Leu Ile Met Cys Ile Ser Val Asp Arg         
    130                 135                 140                         

tac att gcc att gcc cag gcc atg aga gca cat act tgg agg gag aaa      539
Tyr Ile Ala Ile Ala Gln Ala Met Arg Ala His Thr Trp Arg Glu Lys         
145                 150                 155                 160         

agg ctt ttg tac agc aaa atg gtt tgc ttt acc atc tgg gta ttg gca      587
Arg Leu Leu Tyr Ser Lys Met Val Cys Phe Thr Ile Trp Val Leu Ala         
                165                 170                 175             

gct gct ctc tgc atc cca gaa atc tta tac agc caa atc aag gag gaa      635
Ala Ala Leu Cys Ile Pro Glu Ile Leu Tyr Ser Gln Ile Lys Glu Glu         
            180                 185                 190                 

tcc ggc att gct atc tgc acc atg gtt tac cct agc gat gag agc acc      683
Ser Gly Ile Ala Ile Cys Thr Met Val Tyr Pro Ser Asp Glu Ser Thr         
        195                 200                 205                     

aaa ctg aag tca gct gtc ttg acc ctg aag gtc att ctg ggg ttc ttc      731
Lys Leu Lys Ser Ala Val Leu Thr Leu Lys Val Ile Leu Gly Phe Phe         
    210                 215                 220                         

ctt ccc ttc gtg gtc atg gct tgc tgc tat acc atc atc att cac acc      779
Leu Pro Phe Val Val Met Ala Cys Cys Tyr Thr Ile Ile Ile His Thr         
225                 230                 235                 240         

ctg ata caa gcc aag aag tct tcc aag cac aaa gcc cta aaa gtg acc      827
Leu Ile Gln Ala Lys Lys Ser Ser Lys His Lys Ala Leu Lys Val Thr         
                245                 250                 255             

atc act gtc ctg acc gtc ttt gtc ttg tct cag ttt ccc tac aac tgc      875
Ile Thr Val Leu Thr Val Phe Val Leu Ser Gln Phe Pro Tyr Asn Cys         
            260                 265                 270                 

att ttg ttg gtg cag acc att gac gcc tat gcc atg ttc atc tcc aac      923
Ile Leu Leu Val Gln Thr Ile Asp Ala Tyr Ala Met Phe Ile Ser Asn         
        275                 280                 285                     

tgt gcc gtt tcc acc aac att gac atc tgc ttc cag gtc acc cag acc      971
Cys Ala Val Ser Thr Asn Ile Asp Ile Cys Phe Gln Val Thr Gln Thr         
    290                 295                 300                         

atc gcc ttc ttc cac agt tgc ctg aac cct gtt ctc tat gtt ttt gtg     1019
Ile Ala Phe Phe His Ser Cys Leu Asn Pro Val Leu Tyr Val Phe Val         
305                 310                 315                 320         

ggt gag aga ttc cgc cgg gat ctc gtg aaa acc ctg aag aac ttg ggt     1067
Gly Glu Arg Phe Arg Arg Asp Leu Val Lys Thr Leu Lys Asn Leu Gly         
                325                 330                 335             

tgc atc agc cag gcc cag tgg gtt tca ttt aca agg aga gag gga agc     1115
Cys Ile Ser Gln Ala Gln Trp Val Ser Phe Thr Arg Arg Glu Gly Ser         
            340                 345                 350                 

ttg aag ctg tcg tct atg ttg ctg gag aca acc tca gga gca ctc tcc     1163
Leu Lys Leu Ser Ser Met Leu Leu Glu Thr Thr Ser Gly Ala Leu Ser         
        355                 360                 365                     

ctc tga ggggtcttct ctgaggt                                          1186
Leu                                                                     
                                                                        


<210>  16
<211>  369
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Thr Pro Thr Asp Phe Thr Ser Pro Ile Pro Asn Met Ala Asp Asp 
1               5                   10                  15      


Tyr Gly Ser Glu Ser Thr Ser Ser Met Glu Asp Tyr Val Asn Phe Asn 
            20                  25                  30          


Phe Thr Asp Phe Tyr Cys Glu Lys Asn Asn Val Arg Gln Phe Ala Ser 
        35                  40                  45              


His Phe Leu Pro Pro Leu Tyr Trp Leu Val Phe Ile Val Gly Ala Leu 
    50                  55                  60                  


Gly Asn Ser Leu Val Ile Leu Val Tyr Trp Tyr Cys Thr Arg Val Lys 
65                  70                  75                  80  


Thr Met Thr Asp Met Phe Leu Leu Asn Leu Ala Ile Ala Asp Leu Leu 
                85                  90                  95      


Phe Leu Val Thr Leu Pro Phe Trp Ala Ile Ala Ala Ala Asp Gln Trp 
            100                 105                 110         


Lys Phe Gln Thr Phe Met Cys Lys Val Val Asn Ser Met Tyr Lys Met 
        115                 120                 125             


Asn Phe Tyr Ser Cys Val Leu Leu Ile Met Cys Ile Ser Val Asp Arg 
    130                 135                 140                 


Tyr Ile Ala Ile Ala Gln Ala Met Arg Ala His Thr Trp Arg Glu Lys 
145                 150                 155                 160 


Arg Leu Leu Tyr Ser Lys Met Val Cys Phe Thr Ile Trp Val Leu Ala 
                165                 170                 175     


Ala Ala Leu Cys Ile Pro Glu Ile Leu Tyr Ser Gln Ile Lys Glu Glu 
            180                 185                 190         


Ser Gly Ile Ala Ile Cys Thr Met Val Tyr Pro Ser Asp Glu Ser Thr 
        195                 200                 205             


Lys Leu Lys Ser Ala Val Leu Thr Leu Lys Val Ile Leu Gly Phe Phe 
    210                 215                 220                 


Leu Pro Phe Val Val Met Ala Cys Cys Tyr Thr Ile Ile Ile His Thr 
225                 230                 235                 240 


Leu Ile Gln Ala Lys Lys Ser Ser Lys His Lys Ala Leu Lys Val Thr 
                245                 250                 255     


Ile Thr Val Leu Thr Val Phe Val Leu Ser Gln Phe Pro Tyr Asn Cys 
            260                 265                 270         


Ile Leu Leu Val Gln Thr Ile Asp Ala Tyr Ala Met Phe Ile Ser Asn 
        275                 280                 285             


Cys Ala Val Ser Thr Asn Ile Asp Ile Cys Phe Gln Val Thr Gln Thr 
    290                 295                 300                 


Ile Ala Phe Phe His Ser Cys Leu Asn Pro Val Leu Tyr Val Phe Val 
305                 310                 315                 320 


Gly Glu Arg Phe Arg Arg Asp Leu Val Lys Thr Leu Lys Asn Leu Gly 
                325                 330                 335     


Cys Ile Ser Gln Ala Gln Trp Val Ser Phe Thr Arg Arg Glu Gly Ser 
            340                 345                 350         


Leu Lys Leu Ser Ser Met Leu Leu Glu Thr Thr Ser Gly Ala Leu Ser 
        355                 360                 365             


Leu 
    


<210>  17
<211>  2400
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1178)..(2260)

<400>  17
caccctccac acccaggctt ccccagagca ggatctgtgc tgtccctgtg gcaagggcag     60

agccccagga gctagactaa atctgagagg aacaggggag tcaaggctag atggaggcac    120

acatgcagga caggaagggt ctccagcagg gctgaaagca ccaagcaagg gtagtgcaaa    180

ccctgtcttc tctgcttcct gctgcccctc tcttattggg tagcagactg gctgtgtctg    240

cttatcccgc atggtggcac atggctgccc agagctcccc aaataacctg ttacgtttcc    300

acccacaggg agaatcaggc agcccgcttg cttattgttt ttaatatact tttccaaact    360

acacagacat tcccaaagcg ggtctccttc tacccaaaag agaaacgctg ggccttacta    420

attaactgaa gactctgcta gctcgagcct tccaaaactc catgccacaa ttgttcaaac    480

cattttccag aatacatctt ttaaaataac ttttagaaaa ttgaacaaag ggattcatgt    540

ctcagcttta tagtcaaacc atgatctttt ctgagggtat agcccatttg gagttcctgc    600

ttaatcccct gattaaaaac tgaatggggc tgagtgcagt gctcatgcct atattcccag    660

cactttggga gacagaggca ggagaattac ttaaggtcag gagtttaaga ccatcctgag    720

caacataaca agtccccatc tctaagacaa aaaaaaaaga actgagtgac atctcacatc    780

tcacatttct gaacattaaa cccagccttg atagccaaag atgctcgcca ctgaaggatc    840

caggtagtat tgagggttct gtggggatta tccaaagaga actttctaca aagttttagg    900

tgatggcgat gctaaaagaa atgctaagaa tttctctctt atattaaaga gaactatggt    960

cctctcataa aatgtaccat ttatcaccaa atttatctca taacctaaga gctaccactt   1020

acaaatttga agggaaaaat tactacattg taatactcaa gccaacacaa agaatcctat   1080

cccagtttct tgagtggatg ggcaagaata tggggaattt attatgcagt aaccttcatc   1140

tctcttctat aggtcaggat ttaagtttac ctcaaaa atg gaa gat ttt aac atg    1195
                                         Met Glu Asp Phe Asn Met        
                                         1               5              

gag agt gac agc ttt gaa gat ttc tgg aaa ggt gaa gat ctt agt aat     1243
Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys Gly Glu Asp Leu Ser Asn         
            10                  15                  20                  

tac agt tac agc tct acc ctg ccc cct ttt cta cta gat gcc gcc cca     1291
Tyr Ser Tyr Ser Ser Thr Leu Pro Pro Phe Leu Leu Asp Ala Ala Pro         
        25                  30                  35                      

tgt gaa cca gaa tcc ctg gaa atc aac aag tat ttt gtg gtc att atc     1339
Cys Glu Pro Glu Ser Leu Glu Ile Asn Lys Tyr Phe Val Val Ile Ile         
    40                  45                  50                          

tat gcc ctg gta ttc ctg ctg agc ctg ctg gga aac tcc ctc gtg atg     1387
Tyr Ala Leu Val Phe Leu Leu Ser Leu Leu Gly Asn Ser Leu Val Met         
55                  60                  65                  70          

ctg gtc atc tta tac agc agg gtc ggc cgc tcc gtc act gat gtc tac     1435
Leu Val Ile Leu Tyr Ser Arg Val Gly Arg Ser Val Thr Asp Val Tyr         
                75                  80                  85              

ctg ctg aac cta gcc ttg gcc gac cta ctc ttt gcc ctg acc ttg ccc     1483
Leu Leu Asn Leu Ala Leu Ala Asp Leu Leu Phe Ala Leu Thr Leu Pro         
            90                  95                  100                 

atc tgg gcc gcc tcc aag gtg aat ggc tgg att ttt ggc aca ttc ctg     1531
Ile Trp Ala Ala Ser Lys Val Asn Gly Trp Ile Phe Gly Thr Phe Leu         
        105                 110                 115                     

tgc aag gtg gtc tca ctc ctg aag gaa gtc aac ttc tat agt ggc atc     1579
Cys Lys Val Val Ser Leu Leu Lys Glu Val Asn Phe Tyr Ser Gly Ile         
    120                 125                 130                         

ctg cta ctg gcc tgc atc agt gtg gac cgt tac ctg gcc att gtc cat     1627
Leu Leu Leu Ala Cys Ile Ser Val Asp Arg Tyr Leu Ala Ile Val His         
135                 140                 145                 150         

gcc aca cgc aca ctg acc cag aag cgc tac ttg gtc aaa ttc ata tgt     1675
Ala Thr Arg Thr Leu Thr Gln Lys Arg Tyr Leu Val Lys Phe Ile Cys         
                155                 160                 165             

ctc agc atc tgg ggt ctg tcc ttg ctc ctg gcc ctg cct gtc tta ctt     1723
Leu Ser Ile Trp Gly Leu Ser Leu Leu Leu Ala Leu Pro Val Leu Leu         
            170                 175                 180                 

ttc cga agg acc gtc tac tca tcc aat gtt agc cca gcc tgc tat gag     1771
Phe Arg Arg Thr Val Tyr Ser Ser Asn Val Ser Pro Ala Cys Tyr Glu         
        185                 190                 195                     

gac atg ggc aac aat aca gca aac tgg cgg atg ctg tta cgg atc ctg     1819
Asp Met Gly Asn Asn Thr Ala Asn Trp Arg Met Leu Leu Arg Ile Leu         
    200                 205                 210                         

ccc cag tcc ttt ggc ttc atc gtg cca ctg ctg atc atg ctg ttc tgc     1867
Pro Gln Ser Phe Gly Phe Ile Val Pro Leu Leu Ile Met Leu Phe Cys         
215                 220                 225                 230         

tac gga ttc acc ctg cgt acg ctg ttt aag gcc cac atg ggg cag aag     1915
Tyr Gly Phe Thr Leu Arg Thr Leu Phe Lys Ala His Met Gly Gln Lys         
                235                 240                 245             

cac cgg gcc atg cgg gtc atc ttt gct gtc gtc ctc atc ttc ctg ctc     1963
His Arg Ala Met Arg Val Ile Phe Ala Val Val Leu Ile Phe Leu Leu         
            250                 255                 260                 

tgc tgg ctg ccc tac aac ctg gtc ctg ctg gca gac acc ctc atg agg     2011
Cys Trp Leu Pro Tyr Asn Leu Val Leu Leu Ala Asp Thr Leu Met Arg         
        265                 270                 275                     

acc cag gtg atc cag gag acc tgt gag cgc cgc aat cac atc gac cgg     2059
Thr Gln Val Ile Gln Glu Thr Cys Glu Arg Arg Asn His Ile Asp Arg         
    280                 285                 290                         

gct ctg gat gcc acc gag att ctg ggc atc ctt cac agc tgc ctc aac     2107
Ala Leu Asp Ala Thr Glu Ile Leu Gly Ile Leu His Ser Cys Leu Asn         
295                 300                 305                 310         

ccc ctc atc tac gcc ttc att ggc cag aag ttt cgc cat gga ctc ctc     2155
Pro Leu Ile Tyr Ala Phe Ile Gly Gln Lys Phe Arg His Gly Leu Leu         
                315                 320                 325             

aag att cta gct ata cat ggc ttg atc agc aag gac tcc ctg ccc aaa     2203
Lys Ile Leu Ala Ile His Gly Leu Ile Ser Lys Asp Ser Leu Pro Lys         
            330                 335                 340                 

gac agc agg cct tcc ttt gtt ggc tct tct tca ggg cac act tcc act     2251
Asp Ser Arg Pro Ser Phe Val Gly Ser Ser Ser Gly His Thr Ser Thr         
        345                 350                 355                     

act ctc taa gacctcctgc ctaagtgcag cccgtggggt tcctcccttc             2300
Thr Leu                                                                 
    360                                                                 

tcttcacagt cacattccaa gcctcatgtc cactggttct tcttggtctc agtgtcaatg   2360

cagcccccat tgtggtcaca ggaagtagag gaggccacgt                         2400


<210>  18
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  18

Met Glu Asp Phe Asn Met Glu Ser Asp Ser Phe Glu Asp Phe Trp Lys 
1               5                   10                  15      


Gly Glu Asp Leu Ser Asn Tyr Ser Tyr Ser Ser Thr Leu Pro Pro Phe 
            20                  25                  30          


Leu Leu Asp Ala Ala Pro Cys Glu Pro Glu Ser Leu Glu Ile Asn Lys 
        35                  40                  45              


Tyr Phe Val Val Ile Ile Tyr Ala Leu Val Phe Leu Leu Ser Leu Leu 
    50                  55                  60                  


Gly Asn Ser Leu Val Met Leu Val Ile Leu Tyr Ser Arg Val Gly Arg 
65                  70                  75                  80  


Ser Val Thr Asp Val Tyr Leu Leu Asn Leu Ala Leu Ala Asp Leu Leu 
                85                  90                  95      


Phe Ala Leu Thr Leu Pro Ile Trp Ala Ala Ser Lys Val Asn Gly Trp 
            100                 105                 110         


Ile Phe Gly Thr Phe Leu Cys Lys Val Val Ser Leu Leu Lys Glu Val 
        115                 120                 125             


Asn Phe Tyr Ser Gly Ile Leu Leu Leu Ala Cys Ile Ser Val Asp Arg 
    130                 135                 140                 


Tyr Leu Ala Ile Val His Ala Thr Arg Thr Leu Thr Gln Lys Arg Tyr 
145                 150                 155                 160 


Leu Val Lys Phe Ile Cys Leu Ser Ile Trp Gly Leu Ser Leu Leu Leu 
                165                 170                 175     


Ala Leu Pro Val Leu Leu Phe Arg Arg Thr Val Tyr Ser Ser Asn Val 
            180                 185                 190         


Ser Pro Ala Cys Tyr Glu Asp Met Gly Asn Asn Thr Ala Asn Trp Arg 
        195                 200                 205             


Met Leu Leu Arg Ile Leu Pro Gln Ser Phe Gly Phe Ile Val Pro Leu 
    210                 215                 220                 


Leu Ile Met Leu Phe Cys Tyr Gly Phe Thr Leu Arg Thr Leu Phe Lys 
225                 230                 235                 240 


Ala His Met Gly Gln Lys His Arg Ala Met Arg Val Ile Phe Ala Val 
                245                 250                 255     


Val Leu Ile Phe Leu Leu Cys Trp Leu Pro Tyr Asn Leu Val Leu Leu 
            260                 265                 270         


Ala Asp Thr Leu Met Arg Thr Gln Val Ile Gln Glu Thr Cys Glu Arg 
        275                 280                 285             


Arg Asn His Ile Asp Arg Ala Leu Asp Ala Thr Glu Ile Leu Gly Ile 
    290                 295                 300                 


Leu His Ser Cys Leu Asn Pro Leu Ile Tyr Ala Phe Ile Gly Gln Lys 
305                 310                 315                 320 


Phe Arg His Gly Leu Leu Lys Ile Leu Ala Ile His Gly Leu Ile Ser 
                325                 330                 335     


Lys Asp Ser Leu Pro Lys Asp Ser Arg Pro Ser Phe Val Gly Ser Ser 
            340                 345                 350         


Ser Gly His Thr Ser Thr Thr Leu 
        355                 360 


<210>  19
<211>  1029
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1029)

<400>  19
atg gca gag cat gat tac cat gaa gac tat ggg ttc agc agt ttc aat       48
Met Ala Glu His Asp Tyr His Glu Asp Tyr Gly Phe Ser Ser Phe Asn         
1               5                   10                  15              

gac agc agc cag gag gag cat caa gac ttc ctg cag ttc agc aag gtc       96
Asp Ser Ser Gln Glu Glu His Gln Asp Phe Leu Gln Phe Ser Lys Val         
            20                  25                  30                  

ttt ctg ccc tgc atg tac ctg gtg gtg ttt gtc tgt ggt ctg gtg ggg      144
Phe Leu Pro Cys Met Tyr Leu Val Val Phe Val Cys Gly Leu Val Gly         
        35                  40                  45                      

aac tct ctg gtg ctg gtc ata tcc atc ttc tac cat aag ttg cag agc      192
Asn Ser Leu Val Leu Val Ile Ser Ile Phe Tyr His Lys Leu Gln Ser         
    50                  55                  60                          

ctg acg gat gtg ttc ctg gtg aac cta ccc ctg gct gac ctg gtg ttt      240
Leu Thr Asp Val Phe Leu Val Asn Leu Pro Leu Ala Asp Leu Val Phe         
65                  70                  75                  80          

gtc tgc act ctg ccc ttc tgg gcc tat gca ggc atc cat gaa tgg gtg      288
Val Cys Thr Leu Pro Phe Trp Ala Tyr Ala Gly Ile His Glu Trp Val         
                85                  90                  95              

ttt ggc cag gtc atg tgc aag agc cta ctg ggc atc tac act att aac      336
Phe Gly Gln Val Met Cys Lys Ser Leu Leu Gly Ile Tyr Thr Ile Asn         
            100                 105                 110                 

ttc tac acg tcc atg ctc atc ctc acc tgc atc act gtg gat cgt ttc      384
Phe Tyr Thr Ser Met Leu Ile Leu Thr Cys Ile Thr Val Asp Arg Phe         
        115                 120                 125                     

att gta gtg gtt aag gcc acc aag gcc tac aac cag caa gcc aag agg      432
Ile Val Val Val Lys Ala Thr Lys Ala Tyr Asn Gln Gln Ala Lys Arg         
    130                 135                 140                         

atg acc tgg ggc aag gtc acc agc ttg ctc atc tgg gtg ata tcc ctg      480
Met Thr Trp Gly Lys Val Thr Ser Leu Leu Ile Trp Val Ile Ser Leu         
145                 150                 155                 160         

ctg gtt tcc ttg ccc caa att atc tat ggc aat gtc ttt aat ctc gac      528
Leu Val Ser Leu Pro Gln Ile Ile Tyr Gly Asn Val Phe Asn Leu Asp         
                165                 170                 175             

aag ctc ata tgt ggt tac cat gac gag gca att tcc act gtg gtt ctt      576
Lys Leu Ile Cys Gly Tyr His Asp Glu Ala Ile Ser Thr Val Val Leu         
            180                 185                 190                 

gcc acc cag atg aca ctg ggg ttc ttc ttg cca ctg ctc acc atg att      624
Ala Thr Gln Met Thr Leu Gly Phe Phe Leu Pro Leu Leu Thr Met Ile         
        195                 200                 205                     

gtc tgc tat tca gtc ata atc aaa aca ctg ctt cat gct gga ggc ttc      672
Val Cys Tyr Ser Val Ile Ile Lys Thr Leu Leu His Ala Gly Gly Phe         
    210                 215                 220                         

cag aag cac aga tct cta aag atc atc ttc ctg gtg atg gct gtg ttc      720
Gln Lys His Arg Ser Leu Lys Ile Ile Phe Leu Val Met Ala Val Phe         
225                 230                 235                 240         

ctg ctg acc cag atg ccc ttc aac ctc atg aag ttc atc cgc agc aca      768
Leu Leu Thr Gln Met Pro Phe Asn Leu Met Lys Phe Ile Arg Ser Thr         
                245                 250                 255             

cac tgg gaa tac tat gcc atg acc agc ttt cac tac acc atc atg gtg      816
His Trp Glu Tyr Tyr Ala Met Thr Ser Phe His Tyr Thr Ile Met Val         
            260                 265                 270                 

aca gag gcc atc gca tac ctg agg gcc tgc ctt aac cct gtg ctc tat      864
Thr Glu Ala Ile Ala Tyr Leu Arg Ala Cys Leu Asn Pro Val Leu Tyr         
        275                 280                 285                     

gcc ttt gtc agc ctg aag ttt cga aag aac ttc tgg aaa ctt gtg aag      912
Ala Phe Val Ser Leu Lys Phe Arg Lys Asn Phe Trp Lys Leu Val Lys         
    290                 295                 300                         

gac att ggt tgc ctc cct tac ctt ggg gtc tca cat caa tgg aaa tct      960
Asp Ile Gly Cys Leu Pro Tyr Leu Gly Val Ser His Gln Trp Lys Ser         
305                 310                 315                 320         

tct gag gac aat tcc aag act ttt tct gcc tcc cac aat gtg gag gcc     1008
Ser Glu Asp Asn Ser Lys Thr Phe Ser Ala Ser His Asn Val Glu Ala         
                325                 330                 335             

acc agc atg ttc cag tta tag                                         1029
Thr Ser Met Phe Gln Leu                                                 
            340                                                         


<210>  20
<211>  342
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Glu His Asp Tyr His Glu Asp Tyr Gly Phe Ser Ser Phe Asn 
1               5                   10                  15      


Asp Ser Ser Gln Glu Glu His Gln Asp Phe Leu Gln Phe Ser Lys Val 
            20                  25                  30          


Phe Leu Pro Cys Met Tyr Leu Val Val Phe Val Cys Gly Leu Val Gly 
        35                  40                  45              


Asn Ser Leu Val Leu Val Ile Ser Ile Phe Tyr His Lys Leu Gln Ser 
    50                  55                  60                  


Leu Thr Asp Val Phe Leu Val Asn Leu Pro Leu Ala Asp Leu Val Phe 
65                  70                  75                  80  


Val Cys Thr Leu Pro Phe Trp Ala Tyr Ala Gly Ile His Glu Trp Val 
                85                  90                  95      


Phe Gly Gln Val Met Cys Lys Ser Leu Leu Gly Ile Tyr Thr Ile Asn 
            100                 105                 110         


Phe Tyr Thr Ser Met Leu Ile Leu Thr Cys Ile Thr Val Asp Arg Phe 
        115                 120                 125             


Ile Val Val Val Lys Ala Thr Lys Ala Tyr Asn Gln Gln Ala Lys Arg 
    130                 135                 140                 


Met Thr Trp Gly Lys Val Thr Ser Leu Leu Ile Trp Val Ile Ser Leu 
145                 150                 155                 160 


Leu Val Ser Leu Pro Gln Ile Ile Tyr Gly Asn Val Phe Asn Leu Asp 
                165                 170                 175     


Lys Leu Ile Cys Gly Tyr His Asp Glu Ala Ile Ser Thr Val Val Leu 
            180                 185                 190         


Ala Thr Gln Met Thr Leu Gly Phe Phe Leu Pro Leu Leu Thr Met Ile 
        195                 200                 205             


Val Cys Tyr Ser Val Ile Ile Lys Thr Leu Leu His Ala Gly Gly Phe 
    210                 215                 220                 


Gln Lys His Arg Ser Leu Lys Ile Ile Phe Leu Val Met Ala Val Phe 
225                 230                 235                 240 


Leu Leu Thr Gln Met Pro Phe Asn Leu Met Lys Phe Ile Arg Ser Thr 
                245                 250                 255     


His Trp Glu Tyr Tyr Ala Met Thr Ser Phe His Tyr Thr Ile Met Val 
            260                 265                 270         


Thr Glu Ala Ile Ala Tyr Leu Arg Ala Cys Leu Asn Pro Val Leu Tyr 
        275                 280                 285             


Ala Phe Val Ser Leu Lys Phe Arg Lys Asn Phe Trp Lys Leu Val Lys 
    290                 295                 300                 


Asp Ile Gly Cys Leu Pro Tyr Leu Gly Val Ser His Gln Trp Lys Ser 
305                 310                 315                 320 


Ser Glu Asp Asn Ser Lys Thr Phe Ser Ala Ser His Asn Val Glu Ala 
                325                 330                 335     


Thr Ser Met Phe Gln Leu 
            340         


<210>  21
<211>  1260
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (93)..(1160)

<400>  21
gaaatactcg tctctggtaa agtctgagca ggacagggtg gctgactggc agatccagag     60

gttcccttgg cagtccacgc caggccttca cc atg gat cag ttc cct gaa tca      113
                                    Met Asp Gln Phe Pro Glu Ser         
                                    1               5                   

gtg aca gaa aac ttt gag tac gat gat ttg gct gag gcc tgt tat att      161
Val Thr Glu Asn Phe Glu Tyr Asp Asp Leu Ala Glu Ala Cys Tyr Ile         
        10                  15                  20                      

ggg gac atc gtg gtc ttt ggg act gtg ttc ctg tcc ata ttc tac tcc      209
Gly Asp Ile Val Val Phe Gly Thr Val Phe Leu Ser Ile Phe Tyr Ser         
    25                  30                  35                          

gtc atc ttt gcc att ggc ctg gtg gga aat ttg ttg gta gtg ttt gcc      257
Val Ile Phe Ala Ile Gly Leu Val Gly Asn Leu Leu Val Val Phe Ala         
40                  45                  50                  55          

ctc acc aac agc aag aag ccc aag agt gtc acc gac att tac ctc ctg      305
Leu Thr Asn Ser Lys Lys Pro Lys Ser Val Thr Asp Ile Tyr Leu Leu         
                60                  65                  70              

aac ctg gcc ttg tct gat ctg ctg ttt gta gcc act ttg ccc ttc tgg      353
Asn Leu Ala Leu Ser Asp Leu Leu Phe Val Ala Thr Leu Pro Phe Trp         
            75                  80                  85                  

act cac tat ttg ata aat gaa aag ggc ctc cac aat gcc atg tgc aaa      401
Thr His Tyr Leu Ile Asn Glu Lys Gly Leu His Asn Ala Met Cys Lys         
        90                  95                  100                     

ttc act acc gcc ttc ttc ttc atc ggc ttt ttt gga agc ata ttc ttc      449
Phe Thr Thr Ala Phe Phe Phe Ile Gly Phe Phe Gly Ser Ile Phe Phe         
    105                 110                 115                         

atc acc gtc atc agc att gat agg tac ctg gcc atc gtc ctg gcc gcc      497
Ile Thr Val Ile Ser Ile Asp Arg Tyr Leu Ala Ile Val Leu Ala Ala         
120                 125                 130                 135         

aac tcc atg aac aac cgg acc gtg cag cat ggc gtc acc atc agc cta      545
Asn Ser Met Asn Asn Arg Thr Val Gln His Gly Val Thr Ile Ser Leu         
                140                 145                 150             

ggc gtc tgg gca gca gcc att ttg gtg gca gca ccc cag ttc atg ttc      593
Gly Val Trp Ala Ala Ala Ile Leu Val Ala Ala Pro Gln Phe Met Phe         
            155                 160                 165                 

aca aag cag aaa gaa aat gaa tgc ctt ggt gac tac ccc gag gtc ctc      641
Thr Lys Gln Lys Glu Asn Glu Cys Leu Gly Asp Tyr Pro Glu Val Leu         
        170                 175                 180                     

cag gaa atc tgg ccc gtg ctc cgc aat gtg gaa aca aat ttt ctt ggc      689
Gln Glu Ile Trp Pro Val Leu Arg Asn Val Glu Thr Asn Phe Leu Gly         
    185                 190                 195                         

ttc cta ctc ccc ctg ctc att atg agt tat tgc tac ttc aga atc atc      737
Phe Leu Leu Pro Leu Leu Ile Met Ser Tyr Cys Tyr Phe Arg Ile Ile         
200                 205                 210                 215         

cag acg ctg ttt tcc tgc aag aac cac aag aaa gcc aaa gcc att aaa      785
Gln Thr Leu Phe Ser Cys Lys Asn His Lys Lys Ala Lys Ala Ile Lys         
                220                 225                 230             

ctg atc ctt ctg gtg gtc atc gtg ttt ttc ctc ttc tgg aca ccc tac      833
Leu Ile Leu Leu Val Val Ile Val Phe Phe Leu Phe Trp Thr Pro Tyr         
            235                 240                 245                 

aac gtt atg att ttc ctg gag acg ctt aag ctc tat gac ttc ttt ccc      881
Asn Val Met Ile Phe Leu Glu Thr Leu Lys Leu Tyr Asp Phe Phe Pro         
        250                 255                 260                     

agt tgt gac atg agg aag gat ctg agg ctg gcc ctc agt gtg act gag      929
Ser Cys Asp Met Arg Lys Asp Leu Arg Leu Ala Leu Ser Val Thr Glu         
    265                 270                 275                         

acg gtt gca ttt agc cat tgt tgc ctg aat cct ctc atc tat gca ttt      977
Thr Val Ala Phe Ser His Cys Cys Leu Asn Pro Leu Ile Tyr Ala Phe         
280                 285                 290                 295         

gct ggg gag aag ttc aga aga tac ctt tac cac ctg tat ggg aaa tgc     1025
Ala Gly Glu Lys Phe Arg Arg Tyr Leu Tyr His Leu Tyr Gly Lys Cys         
                300                 305                 310             

ctg gct gtc ctg tgt ggg cgc tca gtc cac gtt gat ttc tcc tca tct     1073
Leu Ala Val Leu Cys Gly Arg Ser Val His Val Asp Phe Ser Ser Ser         
            315                 320                 325                 

gaa tca caa agg agc agg cat gga agt gtt ctg agc agc aat ttt act     1121
Glu Ser Gln Arg Ser Arg His Gly Ser Val Leu Ser Ser Asn Phe Thr         
        330                 335                 340                     

tac cac acg agt gat gga gat gca ttg ctc ctt ctc tga agggaatccc      1170
Tyr His Thr Ser Asp Gly Asp Ala Leu Leu Leu Leu                         
    345                 350                 355                         

aaagccttgt gtctacagag aacctggagt tcctgaacct gatgctgact agtgaggaaa   1230

gatttttgtt gttatttctt acaggcacaa                                    1260


<210>  22
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  22

Met Asp Gln Phe Pro Glu Ser Val Thr Glu Asn Phe Glu Tyr Asp Asp 
1               5                   10                  15      


Leu Ala Glu Ala Cys Tyr Ile Gly Asp Ile Val Val Phe Gly Thr Val 
            20                  25                  30          


Phe Leu Ser Ile Phe Tyr Ser Val Ile Phe Ala Ile Gly Leu Val Gly 
        35                  40                  45              


Asn Leu Leu Val Val Phe Ala Leu Thr Asn Ser Lys Lys Pro Lys Ser 
    50                  55                  60                  


Val Thr Asp Ile Tyr Leu Leu Asn Leu Ala Leu Ser Asp Leu Leu Phe 
65                  70                  75                  80  


Val Ala Thr Leu Pro Phe Trp Thr His Tyr Leu Ile Asn Glu Lys Gly 
                85                  90                  95      


Leu His Asn Ala Met Cys Lys Phe Thr Thr Ala Phe Phe Phe Ile Gly 
            100                 105                 110         


Phe Phe Gly Ser Ile Phe Phe Ile Thr Val Ile Ser Ile Asp Arg Tyr 
        115                 120                 125             


Leu Ala Ile Val Leu Ala Ala Asn Ser Met Asn Asn Arg Thr Val Gln 
    130                 135                 140                 


His Gly Val Thr Ile Ser Leu Gly Val Trp Ala Ala Ala Ile Leu Val 
145                 150                 155                 160 


Ala Ala Pro Gln Phe Met Phe Thr Lys Gln Lys Glu Asn Glu Cys Leu 
                165                 170                 175     


Gly Asp Tyr Pro Glu Val Leu Gln Glu Ile Trp Pro Val Leu Arg Asn 
            180                 185                 190         


Val Glu Thr Asn Phe Leu Gly Phe Leu Leu Pro Leu Leu Ile Met Ser 
        195                 200                 205             


Tyr Cys Tyr Phe Arg Ile Ile Gln Thr Leu Phe Ser Cys Lys Asn His 
    210                 215                 220                 


Lys Lys Ala Lys Ala Ile Lys Leu Ile Leu Leu Val Val Ile Val Phe 
225                 230                 235                 240 


Phe Leu Phe Trp Thr Pro Tyr Asn Val Met Ile Phe Leu Glu Thr Leu 
                245                 250                 255     


Lys Leu Tyr Asp Phe Phe Pro Ser Cys Asp Met Arg Lys Asp Leu Arg 
            260                 265                 270         


Leu Ala Leu Ser Val Thr Glu Thr Val Ala Phe Ser His Cys Cys Leu 
        275                 280                 285             


Asn Pro Leu Ile Tyr Ala Phe Ala Gly Glu Lys Phe Arg Arg Tyr Leu 
    290                 295                 300                 


Tyr His Leu Tyr Gly Lys Cys Leu Ala Val Leu Cys Gly Arg Ser Val 
305                 310                 315                 320 


His Val Asp Phe Ser Ser Ser Glu Ser Gln Arg Ser Arg His Gly Ser 
                325                 330                 335     


Val Leu Ser Ser Asn Phe Thr Tyr His Thr Ser Asp Gly Asp Ala Leu 
            340                 345                 350         


Leu Leu Leu 
        355 


<210>  23
<211>  1560
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (387)..(1454)

<400>  23
aacagattta cttaaccact ggcaaaccac atttcctttt ccagggcaat aacttaaaat     60

attatgtatt tccctttgtt gcaaagagag gaaatacttc ttcctagact cagggcagct    120

gtgacccgtc ctcccagaga aatcattaaa ccacaaggat tcagacagag cccagagccc    180

tgaaaacttt ggccacgcac tttcccgcag cagccacagg caccggcaac ttcagagagc    240

cagataaaag tggaatgagg aatgcagccg ttctgaacac caccctccat ttcattctgg    300

aaccgggaag gtacacccag gcatgacaat agcttctctc ctcacagaaa tttaactgat    360

ttcttcattc tccatttagc aaggtc atg gaa gat ttg gag gaa aca tta ttt     413
                             Met Glu Asp Leu Glu Glu Thr Leu Phe        
                             1               5                          

gaa gaa ttt gaa aac tat tcc tat gac cta gac tat tac tct ctg gag      461
Glu Glu Phe Glu Asn Tyr Ser Tyr Asp Leu Asp Tyr Tyr Ser Leu Glu         
10                  15                  20                  25          

tct gat ttg gag gag aaa gtc cag ctg gga gtt gtt cac tgg gtc tcc      509
Ser Asp Leu Glu Glu Lys Val Gln Leu Gly Val Val His Trp Val Ser         
                30                  35                  40              

ctg gtg tta tat tgt ttg gct ttt gtt ctg gga att cca gga aat gcc      557
Leu Val Leu Tyr Cys Leu Ala Phe Val Leu Gly Ile Pro Gly Asn Ala         
            45                  50                  55                  

atc gtc att tgg ttc acg ggg ttc aag tgg aag aag aca gtc acc act      605
Ile Val Ile Trp Phe Thr Gly Phe Lys Trp Lys Lys Thr Val Thr Thr         
        60                  65                  70                      

ctg tgg ttc ctc aat cta gcc att gcg gat ttc att ttt ctt ctc ttt      653
Leu Trp Phe Leu Asn Leu Ala Ile Ala Asp Phe Ile Phe Leu Leu Phe         
    75                  80                  85                          

ctg ccc ctg tac atc tcc tat gtg gcc atg aat ttc cac tgg ccc ttt      701
Leu Pro Leu Tyr Ile Ser Tyr Val Ala Met Asn Phe His Trp Pro Phe         
90                  95                  100                 105         

ggc atc tgg ctg tgc aaa gcc aat tcc ttc act gcc cag ttg aac atg      749
Gly Ile Trp Leu Cys Lys Ala Asn Ser Phe Thr Ala Gln Leu Asn Met         
                110                 115                 120             

ttt gcc agt gtt ttt ttc ctg aca gtg atc agc ctg gac cac tat atc      797
Phe Ala Ser Val Phe Phe Leu Thr Val Ile Ser Leu Asp His Tyr Ile         
            125                 130                 135                 

cac ttg atc cat cct gtc tta tct cat cgg cat cga acc ctc aag aac      845
His Leu Ile His Pro Val Leu Ser His Arg His Arg Thr Leu Lys Asn         
        140                 145                 150                     

tct ctg att gtc att ata ttc atc tgg ctt ttg gct tct cta att ggc      893
Ser Leu Ile Val Ile Ile Phe Ile Trp Leu Leu Ala Ser Leu Ile Gly         
    155                 160                 165                         

ggt cct gcc ctg tac ttc cgg gac act gtg gag ttc aat aat cat act      941
Gly Pro Ala Leu Tyr Phe Arg Asp Thr Val Glu Phe Asn Asn His Thr         
170                 175                 180                 185         

ctt tgc tat aac aat ttt cag aag cat gat cct gac ctc act ttg atc      989
Leu Cys Tyr Asn Asn Phe Gln Lys His Asp Pro Asp Leu Thr Leu Ile         
                190                 195                 200             

agg cac cat gtt ctg act tgg gtg aaa ttt atc att ggc tat ctc ttc     1037
Arg His His Val Leu Thr Trp Val Lys Phe Ile Ile Gly Tyr Leu Phe         
            205                 210                 215                 

cct ttg cta aca atg agt att tgc tac ttg tgt ctc atc ttc aag gtg     1085
Pro Leu Leu Thr Met Ser Ile Cys Tyr Leu Cys Leu Ile Phe Lys Val         
        220                 225                 230                     

aag aag cga agc atc ctg atc tcc agt agg cat ttc tgg aca att ctg     1133
Lys Lys Arg Ser Ile Leu Ile Ser Ser Arg His Phe Trp Thr Ile Leu         
    235                 240                 245                         

gtt gtg gtt gtg gcc ttt gtg gtt tgc tgg act cct tat cac ctg ttt     1181
Val Val Val Val Ala Phe Val Val Cys Trp Thr Pro Tyr His Leu Phe         
250                 255                 260                 265         

agc att tgg gag ctc acc att cac cac aat agc tat tcc cac cat gtg     1229
Ser Ile Trp Glu Leu Thr Ile His His Asn Ser Tyr Ser His His Val         
                270                 275                 280             

atg cag gct gga atc ccc ctc tcc act ggt ttg gca ttc ctc aat agt     1277
Met Gln Ala Gly Ile Pro Leu Ser Thr Gly Leu Ala Phe Leu Asn Ser         
            285                 290                 295                 

tgc ttg aac ccc atc ctt tat gtc cta att agt aag aag ttc caa gct     1325
Cys Leu Asn Pro Ile Leu Tyr Val Leu Ile Ser Lys Lys Phe Gln Ala         
        300                 305                 310                     

cgc ttc cgg tcc tca gtt gct gag ata ctc aag tac aca ctg tgg gaa     1373
Arg Phe Arg Ser Ser Val Ala Glu Ile Leu Lys Tyr Thr Leu Trp Glu         
    315                 320                 325                         

gtc agc tgt tct ggc aca gtg agt gaa cag ctc agg aac tca gaa acc     1421
Val Ser Cys Ser Gly Thr Val Ser Glu Gln Leu Arg Asn Ser Glu Thr         
330                 335                 340                 345         

aag aat ctg tgt ctc ctg gaa aca gct caa taa gttattactt ttccacaaat   1474
Lys Asn Leu Cys Leu Leu Glu Thr Ala Gln                                 
                350                 355                                 

cagtatatgg ctttttatgt gggtcctctg actgatgctt tcagattaaa attgtttcca   1534

agatagagag ccgactccac tttcat                                        1560


<210>  24
<211>  355
<212>  PRT
<213>  Homo sapiens

<400>  24

Met Glu Asp Leu Glu Glu Thr Leu Phe Glu Glu Phe Glu Asn Tyr Ser 
1               5                   10                  15      


Tyr Asp Leu Asp Tyr Tyr Ser Leu Glu Ser Asp Leu Glu Glu Lys Val 
            20                  25                  30          


Gln Leu Gly Val Val His Trp Val Ser Leu Val Leu Tyr Cys Leu Ala 
        35                  40                  45              


Phe Val Leu Gly Ile Pro Gly Asn Ala Ile Val Ile Trp Phe Thr Gly 
    50                  55                  60                  


Phe Lys Trp Lys Lys Thr Val Thr Thr Leu Trp Phe Leu Asn Leu Ala 
65                  70                  75                  80  


Ile Ala Asp Phe Ile Phe Leu Leu Phe Leu Pro Leu Tyr Ile Ser Tyr 
                85                  90                  95      


Val Ala Met Asn Phe His Trp Pro Phe Gly Ile Trp Leu Cys Lys Ala 
            100                 105                 110         


Asn Ser Phe Thr Ala Gln Leu Asn Met Phe Ala Ser Val Phe Phe Leu 
        115                 120                 125             


Thr Val Ile Ser Leu Asp His Tyr Ile His Leu Ile His Pro Val Leu 
    130                 135                 140                 


Ser His Arg His Arg Thr Leu Lys Asn Ser Leu Ile Val Ile Ile Phe 
145                 150                 155                 160 


Ile Trp Leu Leu Ala Ser Leu Ile Gly Gly Pro Ala Leu Tyr Phe Arg 
                165                 170                 175     


Asp Thr Val Glu Phe Asn Asn His Thr Leu Cys Tyr Asn Asn Phe Gln 
            180                 185                 190         


Lys His Asp Pro Asp Leu Thr Leu Ile Arg His His Val Leu Thr Trp 
        195                 200                 205             


Val Lys Phe Ile Ile Gly Tyr Leu Phe Pro Leu Leu Thr Met Ser Ile 
    210                 215                 220                 


Cys Tyr Leu Cys Leu Ile Phe Lys Val Lys Lys Arg Ser Ile Leu Ile 
225                 230                 235                 240 


Ser Ser Arg His Phe Trp Thr Ile Leu Val Val Val Val Ala Phe Val 
                245                 250                 255     


Val Cys Trp Thr Pro Tyr His Leu Phe Ser Ile Trp Glu Leu Thr Ile 
            260                 265                 270         


His His Asn Ser Tyr Ser His His Val Met Gln Ala Gly Ile Pro Leu 
        275                 280                 285             


Ser Thr Gly Leu Ala Phe Leu Asn Ser Cys Leu Asn Pro Ile Leu Tyr 
    290                 295                 300                 


Val Leu Ile Ser Lys Lys Phe Gln Ala Arg Phe Arg Ser Ser Val Ala 
305                 310                 315                 320 


Glu Ile Leu Lys Tyr Thr Leu Trp Glu Val Ser Cys Ser Gly Thr Val 
                325                 330                 335     


Ser Glu Gln Leu Arg Asn Ser Glu Thr Lys Asn Leu Cys Leu Leu Glu 
            340                 345                 350         


Thr Ala Gln 
        355 


<210>  25
<211>  1083
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (1)..(1083)

<400>  25
atg gac cca gaa gaa act tca gtt tat ttg gat tat tac tat gct acg       48
Met Asp Pro Glu Glu Thr Ser Val Tyr Leu Asp Tyr Tyr Tyr Ala Thr         
1               5                   10                  15              

agc cca aac tct gac atc agg gag acc cac tcc cat gtt cct tac acc       96
Ser Pro Asn Ser Asp Ile Arg Glu Thr His Ser His Val Pro Tyr Thr         
            20                  25                  30                  

tct gtc ttc ctt cca gtc ttt tac aca gct gtg ttc ctg act gga gtg      144
Ser Val Phe Leu Pro Val Phe Tyr Thr Ala Val Phe Leu Thr Gly Val         
        35                  40                  45                      

ctg ggg aac ctt gtt ctc atg gga gcg ttg cat ttc aaa ccc ggc agc      192
Leu Gly Asn Leu Val Leu Met Gly Ala Leu His Phe Lys Pro Gly Ser         
    50                  55                  60                          

cga aga ctg atc gac atc ttt atc atc aat ctg gct gcc tct gac ttc      240
Arg Arg Leu Ile Asp Ile Phe Ile Ile Asn Leu Ala Ala Ser Asp Phe         
65                  70                  75                  80          

att ttt ctt gtc aca ttg cct ctc tgg gtg gat aaa gaa gca tct cta      288
Ile Phe Leu Val Thr Leu Pro Leu Trp Val Asp Lys Glu Ala Ser Leu         
                85                  90                  95              

gga ctg tgg agg acg ggc tcc ttc ctg tgc aaa ggg agc tcc tac atg      336
Gly Leu Trp Arg Thr Gly Ser Phe Leu Cys Lys Gly Ser Ser Tyr Met         
            100                 105                 110                 

atc tcc gtc aat atg cac tgc agt gtc ctc ctg ctc act tgc atg agt      384
Ile Ser Val Asn Met His Cys Ser Val Leu Leu Leu Thr Cys Met Ser         
        115                 120                 125                     

gtt gac cgc tac ctg gcc att gtg tgg cca gtc gta tcc agg aaa ttc      432
Val Asp Arg Tyr Leu Ala Ile Val Trp Pro Val Val Ser Arg Lys Phe         
    130                 135                 140                         

aga agg aca gac tgt gca tat gta gtc tgt gcc agc atc tgg ttt atc      480
Arg Arg Thr Asp Cys Ala Tyr Val Val Cys Ala Ser Ile Trp Phe Ile         
145                 150                 155                 160         

tcc tgc ctg ctg ggg ttg cct act ctt ctg tcc agg gag ctc acg ctg      528
Ser Cys Leu Leu Gly Leu Pro Thr Leu Leu Ser Arg Glu Leu Thr Leu         
                165                 170                 175             

att gat gat aag cca tac tgt gca gag aaa aag gca act cca att aaa      576
Ile Asp Asp Lys Pro Tyr Cys Ala Glu Lys Lys Ala Thr Pro Ile Lys         
            180                 185                 190                 

ctc ata tgg tcc ctg gtg gcc tta att ttc acc ttt ttt gtc cct ttg      624
Leu Ile Trp Ser Leu Val Ala Leu Ile Phe Thr Phe Phe Val Pro Leu         
        195                 200                 205                     

ttg agc att gtg acc tgc tac tgt tgc att gca agg aag ctg tgt gcc      672
Leu Ser Ile Val Thr Cys Tyr Cys Cys Ile Ala Arg Lys Leu Cys Ala         
    210                 215                 220                         

cat tac cag caa tca gga aag cac aac aaa aag ctg aag aaa tct ata      720
His Tyr Gln Gln Ser Gly Lys His Asn Lys Lys Leu Lys Lys Ser Ile         
225                 230                 235                 240         

aag atc atc ttt att gtc gtg gca gcc ttt ctt gtc tcc tgg ctg ccc      768
Lys Ile Ile Phe Ile Val Val Ala Ala Phe Leu Val Ser Trp Leu Pro         
                245                 250                 255             

ttc aat act ttc aag ttc ctg gcc att gtc tct ggg ttg cgg caa gaa      816
Phe Asn Thr Phe Lys Phe Leu Ala Ile Val Ser Gly Leu Arg Gln Glu         
            260                 265                 270                 

cac tat tta ccc tca gct att ctt cag ctt ggt atg gag gtg agt gga      864
His Tyr Leu Pro Ser Ala Ile Leu Gln Leu Gly Met Glu Val Ser Gly         
        275                 280                 285                     

ccc ttg gca ttt gcc aac agc tgt gtc aac cct ttc att tac tat atc      912
Pro Leu Ala Phe Ala Asn Ser Cys Val Asn Pro Phe Ile Tyr Tyr Ile         
    290                 295                 300                         

ttc gac agc tac atc cgc cgg gcc att gtc cac tgc ttg tgc cct tgc      960
Phe Asp Ser Tyr Ile Arg Arg Ala Ile Val His Cys Leu Cys Pro Cys         
305                 310                 315                 320         

ctg aaa aac tat gac ttt ggg agt agc act gag aca tca gat agt cac     1008
Leu Lys Asn Tyr Asp Phe Gly Ser Ser Thr Glu Thr Ser Asp Ser His         
                325                 330                 335             

ctc act aag gct ctc tcc acc ttc att cat gca gaa gat ttt gcc agg     1056
Leu Thr Lys Ala Leu Ser Thr Phe Ile His Ala Glu Asp Phe Ala Arg         
            340                 345                 350                 

agg agg aag agg tct gtg tca ctc taa                                 1083
Arg Arg Lys Arg Ser Val Ser Leu                                         
        355                 360                                         


<210>  26
<211>  360
<212>  PRT
<213>  Homo sapiens

<400>  26

Met Asp Pro Glu Glu Thr Ser Val Tyr Leu Asp Tyr Tyr Tyr Ala Thr 
1               5                   10                  15      


Ser Pro Asn Ser Asp Ile Arg Glu Thr His Ser His Val Pro Tyr Thr 
            20                  25                  30          


Ser Val Phe Leu Pro Val Phe Tyr Thr Ala Val Phe Leu Thr Gly Val 
        35                  40                  45              


Leu Gly Asn Leu Val Leu Met Gly Ala Leu His Phe Lys Pro Gly Ser 
    50                  55                  60                  


Arg Arg Leu Ile Asp Ile Phe Ile Ile Asn Leu Ala Ala Ser Asp Phe 
65                  70                  75                  80  


Ile Phe Leu Val Thr Leu Pro Leu Trp Val Asp Lys Glu Ala Ser Leu 
                85                  90                  95      


Gly Leu Trp Arg Thr Gly Ser Phe Leu Cys Lys Gly Ser Ser Tyr Met 
            100                 105                 110         


Ile Ser Val Asn Met His Cys Ser Val Leu Leu Leu Thr Cys Met Ser 
        115                 120                 125             


Val Asp Arg Tyr Leu Ala Ile Val Trp Pro Val Val Ser Arg Lys Phe 
    130                 135                 140                 


Arg Arg Thr Asp Cys Ala Tyr Val Val Cys Ala Ser Ile Trp Phe Ile 
145                 150                 155                 160 


Ser Cys Leu Leu Gly Leu Pro Thr Leu Leu Ser Arg Glu Leu Thr Leu 
                165                 170                 175     


Ile Asp Asp Lys Pro Tyr Cys Ala Glu Lys Lys Ala Thr Pro Ile Lys 
            180                 185                 190         


Leu Ile Trp Ser Leu Val Ala Leu Ile Phe Thr Phe Phe Val Pro Leu 
        195                 200                 205             


Leu Ser Ile Val Thr Cys Tyr Cys Cys Ile Ala Arg Lys Leu Cys Ala 
    210                 215                 220                 


His Tyr Gln Gln Ser Gly Lys His Asn Lys Lys Leu Lys Lys Ser Ile 
225                 230                 235                 240 


Lys Ile Ile Phe Ile Val Val Ala Ala Phe Leu Val Ser Trp Leu Pro 
                245                 250                 255     


Phe Asn Thr Phe Lys Phe Leu Ala Ile Val Ser Gly Leu Arg Gln Glu 
            260                 265                 270         


His Tyr Leu Pro Ser Ala Ile Leu Gln Leu Gly Met Glu Val Ser Gly 
        275                 280                 285             


Pro Leu Ala Phe Ala Asn Ser Cys Val Asn Pro Phe Ile Tyr Tyr Ile 
    290                 295                 300                 


Phe Asp Ser Tyr Ile Arg Arg Ala Ile Val His Cys Leu Cys Pro Cys 
305                 310                 315                 320 


Leu Lys Asn Tyr Asp Phe Gly Ser Ser Thr Glu Thr Ser Asp Ser His 
                325                 330                 335     


Leu Thr Lys Ala Leu Ser Thr Phe Ile His Ala Glu Asp Phe Ala Arg 
            340                 345                 350         


Arg Arg Lys Arg Ser Val Ser Leu 
        355                 360 


<210>  27
<211>  1680
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (450)..(1592)

<400>  27
ggaaagccga cttgcaaaac cacagataat gttcagccca gcacagtagg ggtcaatttg     60

gtccacttgc tcagtgacaa aaagaaaaaa aaagtgggct gtcactaaag attttgactc    120

acaagagagg ggctggtctg gaggtgggag gagggagtga cgagtcaagg aggagacagg    180

gacgcaggag ggtgcaagga agtgtcttaa ctgagacggg ggtaaggcaa gagagggtgg    240

aggaaattct gcaggagaca ggcttcctcc agggtctgga gaacccagag gcagctcctc    300

ctgagtgctg ggaaggactc tgggcatctt cagcccttct tactctctga ggctcaagcc    360

agaaattcag gctgcttgca gagtgggtga cagagccacg gagctggtgt ccctgggacc    420

ctctgcccgt cttctctcca ctccccagc atg gag gaa ggt ggt gat ttt gac      473
                                Met Glu Glu Gly Gly Asp Phe Asp         
                                1               5                       

aac tac tat ggg gca gac aac cag tct gag tgt gag tac aca gac tgg      521
Asn Tyr Tyr Gly Ala Asp Asn Gln Ser Glu Cys Glu Tyr Thr Asp Trp         
    10                  15                  20                          

aaa tcc tcg ggg gcc ctc atc cct gcc atc tac atg ttg gtc ttc ctc      569
Lys Ser Ser Gly Ala Leu Ile Pro Ala Ile Tyr Met Leu Val Phe Leu         
25                  30                  35                  40          

ctg ggc acc acg ggc aac ggt ctg gtg ctc tgg acc gtg ttt cgg agc      617
Leu Gly Thr Thr Gly Asn Gly Leu Val Leu Trp Thr Val Phe Arg Ser         
                45                  50                  55              

agc cgg gag aag agg cgc tca gct gat atc ttc att gct agc ctg gcg      665
Ser Arg Glu Lys Arg Arg Ser Ala Asp Ile Phe Ile Ala Ser Leu Ala         
            60                  65                  70                  

gtg gct gac ctg acc ttc gtg gtg acg ctg ccc ctg tgg gct acc tac      713
Val Ala Asp Leu Thr Phe Val Val Thr Leu Pro Leu Trp Ala Thr Tyr         
        75                  80                  85                      

acg tac cgg gac tat gac tgg ccc ttt ggg acc ttc ttc tgc aag ctc      761
Thr Tyr Arg Asp Tyr Asp Trp Pro Phe Gly Thr Phe Phe Cys Lys Leu         
    90                  95                  100                         

agc agc tac ctc atc ttc gtc aac atg tac gcc agc gtc ttc tgc ctc      809
Ser Ser Tyr Leu Ile Phe Val Asn Met Tyr Ala Ser Val Phe Cys Leu         
105                 110                 115                 120         

acc ggc ctc agc ttc gac cgc tac ctg gcc atc gtg agg cca gtg gcc      857
Thr Gly Leu Ser Phe Asp Arg Tyr Leu Ala Ile Val Arg Pro Val Ala         
                125                 130                 135             

aat gct cgg ctg agg ctg cgg gtc agc ggg gcc gtg gcc acg gca gtt      905
Asn Ala Arg Leu Arg Leu Arg Val Ser Gly Ala Val Ala Thr Ala Val         
            140                 145                 150                 

ctt tgg gtg ctg gcc gcc ctc ctg gcc atg cct gtc atg gtg tta cgc      953
Leu Trp Val Leu Ala Ala Leu Leu Ala Met Pro Val Met Val Leu Arg         
        155                 160                 165                     

acc acc ggg gac ttg gag aac acc act aag gtg cag tgc tac atg gac     1001
Thr Thr Gly Asp Leu Glu Asn Thr Thr Lys Val Gln Cys Tyr Met Asp         
    170                 175                 180                         

tac tcc atg gtg gcc act gtg agc tca gag tgg gcc tgg gag gtg ggc     1049
Tyr Ser Met Val Ala Thr Val Ser Ser Glu Trp Ala Trp Glu Val Gly         
185                 190                 195                 200         

ctt ggg gtc tcg tcc acc acc gtg ggc ttt gtg gtg ccc ttc acc atc     1097
Leu Gly Val Ser Ser Thr Thr Val Gly Phe Val Val Pro Phe Thr Ile         
                205                 210                 215             

atg ctg acc tgt tac ttc ttc atc gcc caa acc atc gct ggc cac ttc     1145
Met Leu Thr Cys Tyr Phe Phe Ile Ala Gln Thr Ile Ala Gly His Phe         
            220                 225                 230                 

cgc aag gaa cgc atc gag ggc ctg cgg aag cgg cgc cgg ctg ctc agc     1193
Arg Lys Glu Arg Ile Glu Gly Leu Arg Lys Arg Arg Arg Leu Leu Ser         
        235                 240                 245                     

atc atc gtg gtg ctg gtg gtg acc ttt gcc ctg tgc tgg atg ccc tac     1241
Ile Ile Val Val Leu Val Val Thr Phe Ala Leu Cys Trp Met Pro Tyr         
    250                 255                 260                         

cac ctg gtg aag acg ctg tac atg ctg ggc agc ctg ctg cac tgg ccc     1289
His Leu Val Lys Thr Leu Tyr Met Leu Gly Ser Leu Leu His Trp Pro         
265                 270                 275                 280         

tgt gac ttt gac ctc ttc ctc atg aac atc ttc ccc tac tgc acc tgc     1337
Cys Asp Phe Asp Leu Phe Leu Met Asn Ile Phe Pro Tyr Cys Thr Cys         
                285                 290                 295             

atc agc tac gtc aac agc tgc ctc aac ccc ttc ctc tat gcc ttt ttc     1385
Ile Ser Tyr Val Asn Ser Cys Leu Asn Pro Phe Leu Tyr Ala Phe Phe         
            300                 305                 310                 

gac ccc cgc ttc cgc cag gcc tgc acc tcc atg ctc tgc tgt ggc cag     1433
Asp Pro Arg Phe Arg Gln Ala Cys Thr Ser Met Leu Cys Cys Gly Gln         
        315                 320                 325                     

agc agg tgc gca ggc acc tcc cac agc agc agt ggg gag aag tca gcc     1481
Ser Arg Cys Ala Gly Thr Ser His Ser Ser Ser Gly Glu Lys Ser Ala         
    330                 335                 340                         

agc tac tct tcg ggg cac agc cag ggg ccc ggc ccc aac atg ggc aag     1529
Ser Tyr Ser Ser Gly His Ser Gln Gly Pro Gly Pro Asn Met Gly Lys         
345                 350                 355                 360         

ggt gga gaa cag atg cac gag aaa tcc atc ccc tac agc cag gag acc     1577
Gly Gly Glu Gln Met His Glu Lys Ser Ile Pro Tyr Ser Gln Glu Thr         
                365                 370                 375             

ctt gtg gtt gac tag ggctgggagc agagagaagc ctggcgccct cggccctccc     1632
Leu Val Val Asp                                                         
            380                                                         

cggcctttgc ccttgctttc tgaaaatcag gtagtgtggc tactcctt                1680


<210>  28
<211>  380
<212>  PRT
<213>  Homo sapiens

<400>  28

Met Glu Glu Gly Gly Asp Phe Asp Asn Tyr Tyr Gly Ala Asp Asn Gln 
1               5                   10                  15      


Ser Glu Cys Glu Tyr Thr Asp Trp Lys Ser Ser Gly Ala Leu Ile Pro 
            20                  25                  30          


Ala Ile Tyr Met Leu Val Phe Leu Leu Gly Thr Thr Gly Asn Gly Leu 
        35                  40                  45              


Val Leu Trp Thr Val Phe Arg Ser Ser Arg Glu Lys Arg Arg Ser Ala 
    50                  55                  60                  


Asp Ile Phe Ile Ala Ser Leu Ala Val Ala Asp Leu Thr Phe Val Val 
65                  70                  75                  80  


Thr Leu Pro Leu Trp Ala Thr Tyr Thr Tyr Arg Asp Tyr Asp Trp Pro 
                85                  90                  95      


Phe Gly Thr Phe Phe Cys Lys Leu Ser Ser Tyr Leu Ile Phe Val Asn 
            100                 105                 110         


Met Tyr Ala Ser Val Phe Cys Leu Thr Gly Leu Ser Phe Asp Arg Tyr 
        115                 120                 125             


Leu Ala Ile Val Arg Pro Val Ala Asn Ala Arg Leu Arg Leu Arg Val 
    130                 135                 140                 


Ser Gly Ala Val Ala Thr Ala Val Leu Trp Val Leu Ala Ala Leu Leu 
145                 150                 155                 160 


Ala Met Pro Val Met Val Leu Arg Thr Thr Gly Asp Leu Glu Asn Thr 
                165                 170                 175     


Thr Lys Val Gln Cys Tyr Met Asp Tyr Ser Met Val Ala Thr Val Ser 
            180                 185                 190         


Ser Glu Trp Ala Trp Glu Val Gly Leu Gly Val Ser Ser Thr Thr Val 
        195                 200                 205             


Gly Phe Val Val Pro Phe Thr Ile Met Leu Thr Cys Tyr Phe Phe Ile 
    210                 215                 220                 


Ala Gln Thr Ile Ala Gly His Phe Arg Lys Glu Arg Ile Glu Gly Leu 
225                 230                 235                 240 


Arg Lys Arg Arg Arg Leu Leu Ser Ile Ile Val Val Leu Val Val Thr 
                245                 250                 255     


Phe Ala Leu Cys Trp Met Pro Tyr His Leu Val Lys Thr Leu Tyr Met 
            260                 265                 270         


Leu Gly Ser Leu Leu His Trp Pro Cys Asp Phe Asp Leu Phe Leu Met 
        275                 280                 285             


Asn Ile Phe Pro Tyr Cys Thr Cys Ile Ser Tyr Val Asn Ser Cys Leu 
    290                 295                 300                 


Asn Pro Phe Leu Tyr Ala Phe Phe Asp Pro Arg Phe Arg Gln Ala Cys 
305                 310                 315                 320 


Thr Ser Met Leu Cys Cys Gly Gln Ser Arg Cys Ala Gly Thr Ser His 
                325                 330                 335     


Ser Ser Ser Gly Glu Lys Ser Ala Ser Tyr Ser Ser Gly His Ser Gln 
            340                 345                 350         


Gly Pro Gly Pro Asn Met Gly Lys Gly Gly Glu Gln Met His Glu Lys 
        355                 360                 365             


Ser Ile Pro Tyr Ser Gln Glu Thr Leu Val Val Asp 
    370                 375                 380 


<210>  29
<211>  1560
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (355)..(1476)

<400>  29
gaattcggca cgagccccgg cggccagcag ggagctcagg acagagcagg ctccctggga     60

agcctccggg tgataggggt gttccagctg cggcgctctg ggggttcaga gggggatctt    120

gaatgaacaa atgaatgaac tgctttctgg gcaaacagcc acagccagag gagcctgtga    180

ttggcagaaa gaagccaggg tgtgcaagtc tccccaacag cctcgagtgg cctgcagtca    240

cagggaaccc tcaggaagac cttccgggca gagaccagag ggtgtttcta gctgtgtaca    300

gggactgatt ggctgaggac tcacattgga gagctgcaga caacataacg gtga atg      357
                                                            Met         
                                                            1           

aga atg gag gat gaa gat tac aac act tcc atc agt tac ggt gat gaa      405
Arg Met Glu Asp Glu Asp Tyr Asn Thr Ser Ile Ser Tyr Gly Asp Glu         
            5                   10                  15                  

tac cct gat tat tta gac tcc att gtg gtt ttg gag gac tta tcc ccc      453
Tyr Pro Asp Tyr Leu Asp Ser Ile Val Val Leu Glu Asp Leu Ser Pro         
        20                  25                  30                      

ttg gaa gcc agg gtg acc agg atc ttc ctg gtg gtg gtc tac agc atc      501
Leu Glu Ala Arg Val Thr Arg Ile Phe Leu Val Val Val Tyr Ser Ile         
    35                  40                  45                          

gtc tgc ttc ctc ggg att ctg ggc aat ggt ctg gtg atc atc att gcc      549
Val Cys Phe Leu Gly Ile Leu Gly Asn Gly Leu Val Ile Ile Ile Ala         
50                  55                  60                  65          

acc ttc aag atg aag aag aca gtg aac atg gtc tgg ttc ctc aac ctg      597
Thr Phe Lys Met Lys Lys Thr Val Asn Met Val Trp Phe Leu Asn Leu         
                70                  75                  80              

gca gtg gca gat ttc ctg ttc aac gtc ttc ctc cca atc cat atc acc      645
Ala Val Ala Asp Phe Leu Phe Asn Val Phe Leu Pro Ile His Ile Thr         
            85                  90                  95                  

tat gcc gcc atg gac tac cac tgg gtt ttc ggg aca gcc atg tgc aag      693
Tyr Ala Ala Met Asp Tyr His Trp Val Phe Gly Thr Ala Met Cys Lys         
        100                 105                 110                     

atc agc aac ttc ctt ctc atc cac aac atg ttc acc agc gtc ttc ctg      741
Ile Ser Asn Phe Leu Leu Ile His Asn Met Phe Thr Ser Val Phe Leu         
    115                 120                 125                         

ctg acc atc atc agc tct gac cgc tgc atc tct gtg ctc ctc cct gtc      789
Leu Thr Ile Ile Ser Ser Asp Arg Cys Ile Ser Val Leu Leu Pro Val         
130                 135                 140                 145         

tgg tcc cag aac cac cgc agc gtt cgc ctg gct tac atg gcc tgc atg      837
Trp Ser Gln Asn His Arg Ser Val Arg Leu Ala Tyr Met Ala Cys Met         
                150                 155                 160             

gtc atc tgg gtc ctg gct ttc ttc ttg agt tcc cca tct ctc gtc ttc      885
Val Ile Trp Val Leu Ala Phe Phe Leu Ser Ser Pro Ser Leu Val Phe         
            165                 170                 175                 

cgg gac aca gcc aac ctg cat ggg aaa ata tcc tgc ttc aac aac ttc      933
Arg Asp Thr Ala Asn Leu His Gly Lys Ile Ser Cys Phe Asn Asn Phe         
        180                 185                 190                     

agc ctg tcc aca cct ggg tct tcc tcg tgg ccc act cac tcc caa atg      981
Ser Leu Ser Thr Pro Gly Ser Ser Ser Trp Pro Thr His Ser Gln Met         
    195                 200                 205                         

gac cct gtg ggg tat agc cgg cac atg gtg gtg act gtc acc cgc ttc     1029
Asp Pro Val Gly Tyr Ser Arg His Met Val Val Thr Val Thr Arg Phe         
210                 215                 220                 225         

ctc tgt ggc ttc ctg gtc cca gtc ctc atc atc aca gct tgc tac ctc     1077
Leu Cys Gly Phe Leu Val Pro Val Leu Ile Ile Thr Ala Cys Tyr Leu         
                230                 235                 240             

acc atc gtc tgc aaa ctg cac cgc aac cgc ctg gcc aag acc aag aag     1125
Thr Ile Val Cys Lys Leu His Arg Asn Arg Leu Ala Lys Thr Lys Lys         
            245                 250                 255                 

ccc ttc aag att att gtg acc atc atc att acc ttc ttc ctc tgc tgg     1173
Pro Phe Lys Ile Ile Val Thr Ile Ile Ile Thr Phe Phe Leu Cys Trp         
        260                 265                 270                     

tgc ccc tac cac aca ctc aac ctc cta gag ctc cac cac act gcc atg     1221
Cys Pro Tyr His Thr Leu Asn Leu Leu Glu Leu His His Thr Ala Met         
    275                 280                 285                         

cct ggc tct gtc ttc agc ctg ggt ttg ccc ctg gcc act gcc ctt gcc     1269
Pro Gly Ser Val Phe Ser Leu Gly Leu Pro Leu Ala Thr Ala Leu Ala         
290                 295                 300                 305         

att gcc aac agc tgc atg aac ccc att ctg tat gtt ttc atg ggt cag     1317
Ile Ala Asn Ser Cys Met Asn Pro Ile Leu Tyr Val Phe Met Gly Gln         
                310                 315                 320             

gac ttc aag aag ttc aag gtg gcc ctc ttc tct cgc ctg gtc aat gct     1365
Asp Phe Lys Lys Phe Lys Val Ala Leu Phe Ser Arg Leu Val Asn Ala         
            325                 330                 335                 

cta agt gaa gat aca ggc cac tct tcc tac ccc agc cat aga agc ttt     1413
Leu Ser Glu Asp Thr Gly His Ser Ser Tyr Pro Ser His Arg Ser Phe         
        340                 345                 350                     

acc aag atg tca tca atg aat gag agg act tct atg aat gag agg gag     1461
Thr Lys Met Ser Ser Met Asn Glu Arg Thr Ser Met Asn Glu Arg Glu         
    355                 360                 365                         

acc ggc atg ctt tga tcctcactgt ggaacccctc aatggactct ctcaacccag     1516
Thr Gly Met Leu                                                         
370                                                                     

ggacacccaa ggatatgtct tctgaagatc aaggcaagaa cctc                    1560


<210>  30
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  30

Met Arg Met Glu Asp Glu Asp Tyr Asn Thr Ser Ile Ser Tyr Gly Asp 
1               5                   10                  15      


Glu Tyr Pro Asp Tyr Leu Asp Ser Ile Val Val Leu Glu Asp Leu Ser 
            20                  25                  30          


Pro Leu Glu Ala Arg Val Thr Arg Ile Phe Leu Val Val Val Tyr Ser 
        35                  40                  45              


Ile Val Cys Phe Leu Gly Ile Leu Gly Asn Gly Leu Val Ile Ile Ile 
    50                  55                  60                  


Ala Thr Phe Lys Met Lys Lys Thr Val Asn Met Val Trp Phe Leu Asn 
65                  70                  75                  80  


Leu Ala Val Ala Asp Phe Leu Phe Asn Val Phe Leu Pro Ile His Ile 
                85                  90                  95      


Thr Tyr Ala Ala Met Asp Tyr His Trp Val Phe Gly Thr Ala Met Cys 
            100                 105                 110         


Lys Ile Ser Asn Phe Leu Leu Ile His Asn Met Phe Thr Ser Val Phe 
        115                 120                 125             


Leu Leu Thr Ile Ile Ser Ser Asp Arg Cys Ile Ser Val Leu Leu Pro 
    130                 135                 140                 


Val Trp Ser Gln Asn His Arg Ser Val Arg Leu Ala Tyr Met Ala Cys 
145                 150                 155                 160 


Met Val Ile Trp Val Leu Ala Phe Phe Leu Ser Ser Pro Ser Leu Val 
                165                 170                 175     


Phe Arg Asp Thr Ala Asn Leu His Gly Lys Ile Ser Cys Phe Asn Asn 
            180                 185                 190         


Phe Ser Leu Ser Thr Pro Gly Ser Ser Ser Trp Pro Thr His Ser Gln 
        195                 200                 205             


Met Asp Pro Val Gly Tyr Ser Arg His Met Val Val Thr Val Thr Arg 
    210                 215                 220                 


Phe Leu Cys Gly Phe Leu Val Pro Val Leu Ile Ile Thr Ala Cys Tyr 
225                 230                 235                 240 


Leu Thr Ile Val Cys Lys Leu His Arg Asn Arg Leu Ala Lys Thr Lys 
                245                 250                 255     


Lys Pro Phe Lys Ile Ile Val Thr Ile Ile Ile Thr Phe Phe Leu Cys 
            260                 265                 270         


Trp Cys Pro Tyr His Thr Leu Asn Leu Leu Glu Leu His His Thr Ala 
        275                 280                 285             


Met Pro Gly Ser Val Phe Ser Leu Gly Leu Pro Leu Ala Thr Ala Leu 
    290                 295                 300                 


Ala Ile Ala Asn Ser Cys Met Asn Pro Ile Leu Tyr Val Phe Met Gly 
305                 310                 315                 320 


Gln Asp Phe Lys Lys Phe Lys Val Ala Leu Phe Ser Arg Leu Val Asn 
                325                 330                 335     


Ala Leu Ser Glu Asp Thr Gly His Ser Ser Tyr Pro Ser His Arg Ser 
            340                 345                 350         


Phe Thr Lys Met Ser Ser Met Asn Glu Arg Thr Ser Met Asn Glu Arg 
        355                 360                 365             


Glu Thr Gly Met Leu 
    370             


<210>  31
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  31
ugagugugug ugugugagug ugu                                             23


<210>  32
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  32
aggcggggcg ccgcgggacc gc                                              22


<210>  33
<211>  21
<212>  RNA
<213>  Homo sapiens

<400>  33
agggagggac gggggcugug c                                               21


<210>  34
<211>  19
<212>  RNA
<213>  Homo sapiens

<400>  34
gagccaguug gacaggagc                                                  19


<210>  35
<211>  25
<212>  RNA
<213>  Homo sapiens

<400>  35
agggaucgcg ggcggguggc ggccu                                           25


<210>  36
<211>  23
<212>  RNA
<213>  Homo sapiens

<400>  36
aacauucauu gcugucggug ggu                                             23


<210>  37
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  37
ugagguagua guuuguacag uu                                              22


<210>  38
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  38
uguaaacauc cucgacugga ag                                              22


<210>  39
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  39
ucagugcacu acagaacuuu gu                                              22


<210>  40
<211>  22
<212>  RNA
<213>  Homo sapiens

<400>  40
auaaagcuag auaaccgaaa gu                                              22


