                         SEQUENCE LISTING

<110>  Amplimmune, Inc
       Langermann, Solomon
 
<120>  B7-H4 FUSION PROTEINS AND METHODS OF USE THEREOF

<130>  AMP 110.NP2 PCT

<150>  US 61/238,605
<151>  2009-08-31

<150>  US 61/266,854
<151>  2009-12-04

<150>  US 61/254,930
<151>  2009-10-26

<150>  US 61/286,537
<151>  2009-12-15

<150>  US 61/378,361
<151>  2010-08-30

<160>  141   

<170>  PatentIn version 3.5

<210>  1
<211>  852
<212>  DNA
<213>  Mus musculus

<400>  1
atggcttcct tggggcagat catcttttgg agtattatta acatcatcat catcctggct       60

ggggccatcg cactcatcat tggctttggc atttcaggca agcacttcat cacggtcacg      120

accttcacct cagctggaaa cattggagag gacgggaccc tgagctgcac ttttgaacct      180

gacatcaaac tcaacggcat cgtcatccag tggctgaaag aaggcatcaa aggtttggtc      240

cacgagttca aagaaggcaa agacgacctc tcacagcagc atgagatgtt cagaggccgc      300

acagcagtgt ttgctgatca ggtggtagtt ggcaatgctt ccctgagact gaaaaacgtg      360

cagctcacgg atgctggcac ctacacatgt tacatccgca cctcaaaagg caaagggaat      420

gcaaaccttg agtataagac cggagccttc agtatgccag agataaatgt ggactataat      480

gccagttcag agagtttacg ctgcgaggct cctcggtggt tcccccagcc cacagtggcc      540

tgggcatctc aagtcgacca aggagccaat ttctcagaag tctccaacac cagctttgag      600

ttgaactctg agaatgtgac catgaaggtc gtatctgtgc tctacaatgt cacaatcaac      660

aacacatact cctgtatgat tgaaaacgac attgccaaag ccaccgggga catcaaagtg      720

acagattcag aggtcaaaag gcgaagtcag ctgcagttgc tgaactctgg gccttccccg      780

tgtgtttttt cttctgcctt tgtggctggc tgggcactcc tatctctctc ctgttgcctg      840

atgctaagat ga                                                          852


<210>  2
<211>  283
<212>  PRT
<213>  Mus musculus

<400>  2

Met Ala Ser Leu Gly Gln Ile Ile Phe Trp Ser Ile Ile Asn Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Lys His Phe Ile Thr Val Thr Thr Phe Thr Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Thr Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Asn Gly Ile Val Ile Gln Trp Leu Lys Glu Gly Ile Lys Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Asp Leu Ser Gln Gln His Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Val Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Thr Cys Tyr Ile Arg Ser Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Ile Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Ser Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Ala Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Asp Ser Glu Val Lys Arg Arg Ser Gln Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Gly Pro Ser Pro Cys Val Ser Ser Ser Ala Phe Val Ala Gly Trp Ala 
            260                 265                 270         


Leu Leu Ser Leu Ser Cys Cys Leu Met Leu Arg 
        275                 280             


<210>  3
<211>  275
<212>  PRT
<213>  Mus musculus

<400>  3

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Lys His Phe Ile Thr Val Thr 
            20                  25                  30          


Thr Phe Thr Ser Ala Gly Asn Ile Gly Glu Asp Gly Thr Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Asn Gly Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Ile Lys Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Asp Leu Ser Gln Gln His Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Val Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Thr Cys Tyr Ile Arg Ser Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Ile Asn Val Asp Tyr Asn Ala Ser Ser Glu Ser Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Ala Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Asp Ser Glu Val Lys Arg Arg 
225                 230                 235                 240 


Ser Gln Leu Gln Leu Leu Asn Ser Gly Pro Ser Pro Cys Val Ser Ser 
                245                 250                 255     


Ser Ala Phe Val Ala Gly Trp Ala Leu Leu Ser Leu Ser Cys Cys Leu 
            260                 265                 270         


Met Leu Arg 
        275 


<210>  4
<211>  200
<212>  PRT
<213>  Mus musculus

<400>  4

Gly Phe Gly Ile Ser Gly Lys His Phe Ile Thr Val Thr Thr Phe Thr 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Thr Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Asn Gly Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Ile Lys Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Asp Leu Ser 
    50                  55                  60                  


Gln Gln His Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Val Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Thr Cys Tyr Ile Arg Ser Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Ile 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Ser Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Ala Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile 
        195                 200 


<210>  5
<211>  283
<212>  PRT
<213>  Mus musculus

<400>  5

Met Ala Ser Leu Gly Gln Ile Ile Phe Trp Ser Ile Ile Asn Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Lys His Phe Ile Thr Val Thr Thr Phe Thr Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Thr Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Asn Gly Ile Val Ile Gln Trp Leu Lys Glu Gly Ile Lys Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Asp Leu Ser Gln Gln His Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Val Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Thr Cys Tyr Ile Arg Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Ile Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Ser Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Ala Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Asp Ser Glu Val Lys Arg Arg Ser Gln Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Gly Pro Ser Pro Cys Val Phe Ser Ser Ala Phe Val Ala Gly Trp Ala 
            260                 265                 270         


Leu Leu Ser Leu Ser Cys Cys Leu Met Leu Arg 
        275                 280             


<210>  6
<211>  275
<212>  PRT
<213>  Mus musculus

<400>  6

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Lys His Phe Ile Thr Val Thr 
            20                  25                  30          


Thr Phe Thr Ser Ala Gly Asn Ile Gly Glu Asp Gly Thr Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Asn Gly Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Ile Lys Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Asp Leu Ser Gln Gln His Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Val Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Thr Cys Tyr Ile Arg Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Ile Asn Val Asp Tyr Asn Ala Ser Ser Glu Ser Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Ala Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Asp Ser Glu Val Lys Arg Arg 
225                 230                 235                 240 


Ser Gln Leu Gln Leu Leu Asn Ser Gly Pro Ser Pro Cys Val Phe Ser 
                245                 250                 255     


Ser Ala Phe Val Ala Gly Trp Ala Leu Leu Ser Leu Ser Cys Cys Leu 
            260                 265                 270         


Met Leu Arg 
        275 


<210>  7
<211>  256
<212>  PRT
<213>  Mus musculus

<400>  7

Gly Phe Gly Ile Ser Gly Lys His Phe Ile Thr Val Thr Thr Phe Thr 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Thr Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Asn Gly Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Ile Lys Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Asp Leu Ser 
    50                  55                  60                  


Gln Gln His Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Val Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Thr Cys Tyr Ile Arg Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Ile 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Ser Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Ala Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Asp Ser Glu Val Lys Arg Arg Ser Gln Leu 
    210                 215                 220                 


Gln Leu Leu Asn Ser Gly Pro Ser Pro Cys Val Phe Ser Ser Ala Phe 
225                 230                 235                 240 


Val Ala Gly Trp Ala Leu Leu Ser Leu Ser Cys Cys Leu Met Leu Arg 
                245                 250                 255     


<210>  8
<211>  849
<212>  DNA
<213>  Homo sapiens

<400>  8
atggcttccc tggggcagat cctcttctgg agcataatta gcatcatcat tattctggct       60

ggagcaattg cactcatcat tggctttggt atttcaggga gacactccat cacagtcact      120

actgtcgcct cagctgggaa cattggggag gatggaatcc tgagctgcac ttttgaacct      180

gacatcaaac tttctgatat cgtgatacaa tggctgaagg aaggtgtttt aggcttggtc      240

catgagttca aagaaggcaa agatgagctg tcggagcagg atgaaatgtt cagaggccgg      300

acagcagtgt ttgctgatca agtgatagtt ggcaatgcct ctttgcggct gaaaaacgtg      360

caactcacag atgctggcac ctacaaatgt tatatcatca cttctaaagg caaggggaat      420

gctaaccttg agtataaaac tggagccttc agcatgccgg aagtgaatgt ggactataat      480

gccagctcag agaccttgcg gtgtgaggct ccccgatggt tcccccagcc cacagtggtc      540

tgggcatccc aagttgacca gggagccaac ttctcggaag tctccaatac cagctttgag      600

ctgaactctg agaatgtgac catgaaggtt gtgtctgtgc tctacaatgt tacgatcaac      660

aacacatact cctgtatgat tgaaaatgac attgccaaag caacagggga tatcaaagtg      720

acagaatcgg agatcaaaag gcggagtcac ctacagctgc taaactcaaa ggcttctctg      780

tgtgtctctt ctttctttgc catcagctgg gcacttctgc ctctcagccc ttacctgatg      840

ctaaaataa                                                              849


<210>  9
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Lys Ala Ser Leu Cys Val Ser Ser Phe Phe Ala Ile Ser Trp Ala Leu 
            260                 265                 270         


Leu Pro Leu Ser Pro Tyr Leu Met Leu Lys 
        275                 280         


<210>  10
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser His Leu Gln Leu Leu Asn Ser Lys Ala Ser Leu Cys Val Ser Ser 
                245                 250                 255     


Phe Phe Ala Ile Ser Trp Ala Leu Leu Pro Leu Ser Pro Tyr Leu Met 
            260                 265                 270         


Leu Lys 
        


<210>  11
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  11

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu 
    210                 215                 220                 


Gln Leu Leu Asn Ser Lys Ala Ser Leu Cys Val Ser Ser Phe Phe Ala 
225                 230                 235                 240 


Ile Ser Trp Ala Leu Leu Pro Leu Ser Pro Tyr Leu Met Leu Lys 
                245                 250                 255 


<210>  12
<211>  282
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Gln Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Lys Ala Ser Leu Cys Val Ser Ser Phe Phe Ala Ile Ser Trp Ala Leu 
            260                 265                 270         


Leu Pro Leu Ser Pro Tyr Leu Met Leu Lys 
        275                 280         


<210>  13
<211>  274
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Gln Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser His Leu Gln Leu Leu Asn Ser Lys Ala Ser Leu Cys Val Ser Ser 
                245                 250                 255     


Phe Phe Ala Ile Ser Trp Ala Leu Leu Pro Leu Ser Pro Tyr Leu Met 
            260                 265                 270         


Leu Lys 
        


<210>  14
<211>  255
<212>  PRT
<213>  Homo sapiens

<400>  14

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Gln Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu 
    210                 215                 220                 


Gln Leu Leu Asn Ser Lys Ala Ser Leu Cys Val Ser Ser Phe Phe Ala 
225                 230                 235                 240 


Ile Ser Trp Ala Leu Leu Pro Leu Ser Pro Tyr Leu Met Leu Lys 
                245                 250                 255 


<210>  15
<211>  278
<212>  PRT
<213>  Pan troglodytes

<400>  15

Met Lys Pro Leu Thr Ser Arg Ile Ile Ser Ile Ile Ile Ile Leu Ala 
1               5                   10                  15      


Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser Gly Arg His Ser 
            20                  25                  30          


Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly 
        35                  40                  45              


Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val 
    50                  55                  60                  


Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys 
65                  70                  75                  80  


Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg 
                85                  90                  95      


Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg 
            100                 105                 110         


Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile 
        115                 120                 125             


Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly 
    130                 135                 140                 


Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu 
145                 150                 155                 160 


Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val 
                165                 170                 175     


Trp Ala Ser Gln Ile Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn 
            180                 185                 190         


Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser 
        195                 200                 205             


Val Leu Tyr Asn Ala Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu 
    210                 215                 220                 


Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu 
225                 230                 235                 240 


Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser Lys Ala Ser Leu 
                245                 250                 255     


Cys Val Ser Ser Phe Phe Ala Ile Ser Trp Ala Leu Leu Pro Leu Ser 
            260                 265                 270         


Pro Tyr Leu Met Leu Lys 
        275             


<210>  16
<211>  255
<212>  PRT
<213>  Pan troglodytes

<400>  16

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Ile Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Ala Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu 
    210                 215                 220                 


Gln Leu Leu Asn Ser Lys Ala Ser Leu Cys Val Ser Ser Phe Phe Ala 
225                 230                 235                 240 


Ile Ser Trp Ala Leu Leu Pro Leu Ser Pro Tyr Leu Met Leu Lys 
                245                 250                 255 


<210>  17
<211>  282
<212>  PRT
<213>  Macaca mulatta

<400>  17

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Phe Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Ile Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Lys Ala Ser Leu Cys Val Ser Ser Phe Leu Ala Ile Ser Trp Ala Leu 
            260                 265                 270         


Leu Pro Leu Ala Pro Tyr Leu Met Leu Lys 
        275                 280         


<210>  18
<211>  255
<212>  PRT
<213>  Macaca mulatta

<400>  18

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Ile Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu 
    210                 215                 220                 


Gln Leu Leu Asn Ser Lys Ala Ser Leu Cys Val Ser Ser Phe Leu Ala 
225                 230                 235                 240 


Ile Ser Trp Ala Leu Leu Pro Leu Ala Pro Tyr Leu Met Leu Lys 
                245                 250                 255 


<210>  19
<211>  282
<212>  PRT
<213>  Macaca fascicularis

<400>  19

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Phe Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Ile Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Lys Ala Ser Leu Cys Val Ser Ser Phe Leu Ala Ile Ser Trp Ala Leu 
            260                 265                 270         


Pro Pro Leu Ala Pro Tyr Leu Met Leu Lys 
        275                 280         


<210>  20
<211>  255
<212>  PRT
<213>  Macaca fascicularis

<400>  20

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Ile Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu 
    210                 215                 220                 


Gln Leu Leu Asn Ser Lys Ala Ser Leu Cys Val Ser Ser Phe Leu Ala 
225                 230                 235                 240 


Ile Ser Trp Ala Leu Pro Pro Leu Ala Pro Tyr Leu Met Leu Lys 
                245                 250                 255 


<210>  21
<211>  771
<212>  DNA
<213>  Mus musculus

<400>  21
atggcttcct tggggcagat catcttttgg agtattatta acatcatcat catcctggct       60

ggggccatcg cactcatcat tggctttggc atttcaggca agcacttcat cacggtcacg      120

accttcacct cagctggaaa cattggagag gacgggaccc tgagctgcac ttttgaacct      180

gacatcaaac tcaacggcat cgtcatccag tggctgaaag aaggcatcaa aggtttggtc      240

cacgagttca aagaaggcaa agacgacctc tcacagcagc atgagatgtt cagaggccgc      300

acagcagtgt ttgctgatca ggtggtagtt ggcaatgctt ccctgagact gaaaaacgtg      360

cagctcacgg atgctggcac ctacacatgt tacatccgca cctcaaaagg caaagggaat      420

gcaaaccttg agtataagac cggagccttc agtatgccag agataaatgt ggactataat      480

gccagttcag agagtttacg ctgcgaggct cctcggtggt tcccccagcc cacagtggcc      540

tgggcatctc aagtcgacca aggagccaat ttctcagaag tctccaacac cagctttgag      600

ttgaactctg agaatgtgac catgaaggtc gtatctgtgc tctacaatgt cacaatcaac      660

aacacatact cctgtatgat tgaaaacgac attgccaaag ccaccgggga catcaaagtg      720

acagattcag aggtcaaaag gcgaagtcag ctgcagttgc tgaactctgg g               771


<210>  22
<211>  747
<212>  DNA
<213>  Mus musculus

<400>  22
atggagtggt catgggtttt tctgttcttt cttagcgtga ctacaggcgt ccattcagga       60

ttcggcataa gcggcaagca cttcatcaca gttacaacgt ttacaagtgc ggggaacatt      120

ggggaagatg gaacattgtc atgtacattt gagccagata tcaaactcaa tggaatagta      180

attcagtggc ttaaggaggg catcaagggc ctggtccacg aatttaagga ggggaaagac      240

gatctgtctc agcagcacga gatgttcagg ggcagaaccg ccgtcttcgc agaccaggtt      300

gtggtaggca acgccagttt gcggctgaaa aacgtgcagc tgactgacgc cggcacctac      360

acatgctata tccggtcctc taagggcaag gggaacgcta atctcgagta caaaacaggc      420

gccttttcta tgccagagat caacgtggac tataacgcaa gctctgaaag tctgagatgc      480

gaggcgccaa ggtggttccc tcagcccacc gtcgcgtggg cttcccaggt ggatcaaggc      540

gccaactttt ctgaggtttc taacaccagc ttcgaactga acagcgaaaa tgtgacaatg      600

aaggtagtca gcgttctgta taacgtgacc atcaacaata cttactcctg tatgatagaa      660

aatgatatag ccaaggctac aggagatatt aaagtgacgg attcagaagt gaaaaggagg      720

agtcaactgc aactcttgaa tagcggc                                          747


<210>  23
<211>  747
<212>  DNA
<213>  Mus musculus

<400>  23
atggagtggt catgggtttt tctgttcttt cttagcgtga ctacaggcgt ccattcagga       60

ttcggcataa gcggcaagca cttcatcaca gttacaacgt ttacaagtgc ggggaacatt      120

ggggaagatg gaacattgtc atgtacattt gagccagata tcaaactcaa tggaatagta      180

attcagtggc ttaaggaggg catcaagggc ctggtccacg aatttaagga ggggaaagac      240

gatctgtctc agcagcacga gatgttcagg ggcagaaccg ccgtcttcgc agaccaggtt      300

gtggtaggca acgccagttt gcggctgaaa aacgtgcagc tgactgacgc cggcacctac      360

acatgctata tccggacctc taagggcaag gggaacgcta atctcgagta caaaacaggc      420

gccttttcta tgccagagat caacgtggac tataacgcaa gctctgaaag tctgagatgc      480

gaggcgccaa ggtggttccc tcagcccacc gtcgcgtggg cttcccaggt ggatcaaggc      540

gccaactttt ctgaggtttc taacaccagc ttcgaactga acagcgaaaa tgtgacaatg      600

aaggtagtca gcgttctgta taacgtgacc atcaacaata cttactcctg tatgatagaa      660

aatgatatag ccaaggctac aggagatatt aaagtgacgg attcagaagt gaaaaggagg      720

agtcaactgc aactcttgaa tagcggc                                          747


<210>  24
<211>  249
<212>  PRT
<213>  Mus musculus

<400>  24

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Lys His Phe Ile Thr Val Thr 
            20                  25                  30          


Thr Phe Thr Ser Ala Gly Asn Ile Gly Glu Asp Gly Thr Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Asn Gly Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Ile Lys Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Asp Leu Ser Gln Gln His Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Val Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Thr Cys Tyr Ile Arg Ser Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Ile Asn Val Asp Tyr Asn Ala Ser Ser Glu Ser Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Ala Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Asp Ser Glu Val Lys Arg Arg 
225                 230                 235                 240 


Ser Gln Leu Gln Leu Leu Asn Ser Gly 
                245                 


<210>  25
<211>  249
<212>  PRT
<213>  Mus musculus

<400>  25

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Lys His Phe Ile Thr Val Thr 
            20                  25                  30          


Thr Phe Thr Ser Ala Gly Asn Ile Gly Glu Asp Gly Thr Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Asn Gly Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Ile Lys Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Asp Leu Ser Gln Gln His Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Val Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Thr Cys Tyr Ile Arg Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Ile Asn Val Asp Tyr Asn Ala Ser Ser Glu Ser Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Ala Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Asp Ser Glu Val Lys Arg Arg 
225                 230                 235                 240 


Ser Gln Leu Gln Leu Leu Asn Ser Gly 
                245                 


<210>  26
<211>  257
<212>  PRT
<213>  Mus musculus

<400>  26

Met Ala Ser Leu Gly Gln Ile Ile Phe Trp Ser Ile Ile Asn Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Lys His Phe Ile Thr Val Thr Thr Phe Thr Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Thr Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Asn Gly Ile Val Ile Gln Trp Leu Lys Glu Gly Ile Lys Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Asp Leu Ser Gln Gln His Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Val Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Thr Cys Tyr Ile Arg Ser Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Ile Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Ser Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Ala Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Asp Ser Glu Val Lys Arg Arg Ser Gln Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Gly 
    


<210>  27
<211>  257
<212>  PRT
<213>  Mus musculus

<400>  27

Met Ala Ser Leu Gly Gln Ile Ile Phe Trp Ser Ile Ile Asn Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Lys His Phe Ile Thr Val Thr Thr Phe Thr Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Thr Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Asn Gly Ile Val Ile Gln Trp Leu Lys Glu Gly Ile Lys Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Asp Leu Ser Gln Gln His Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Val Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Thr Cys Tyr Ile Arg Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Ile Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Ser Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Ala Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Asp Ser Glu Val Lys Arg Arg Ser Gln Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Gly 
    


<210>  28
<211>  230
<212>  PRT
<213>  Mus musculus

<400>  28

Gly Phe Gly Ile Ser Gly Lys His Phe Ile Thr Val Thr Thr Phe Thr 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Thr Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Asn Gly Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Ile Lys Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Asp Leu Ser 
    50                  55                  60                  


Gln Gln His Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Val Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Thr Cys Tyr Ile Arg Ser Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Ile 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Ser Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Ala Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Asp Ser Glu Val Lys Arg Arg Ser Gln Leu 
    210                 215                 220                 


Gln Leu Leu Asn Ser Gly 
225                 230 


<210>  29
<211>  230
<212>  PRT
<213>  Mus musculus

<400>  29

Gly Phe Gly Ile Ser Gly Lys His Phe Ile Thr Val Thr Thr Phe Thr 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Thr Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Asn Gly Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Ile Lys Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Asp Leu Ser 
    50                  55                  60                  


Gln Gln His Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Val Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Thr Cys Tyr Ile Arg Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Ile 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Ser Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Ala Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Asp Ser Glu Val Lys Arg Arg Ser Gln Leu 
    210                 215                 220                 


Gln Leu Leu Asn Ser Gly 
225                 230 


<210>  30
<211>  387
<212>  DNA
<213>  Mus musculus

<400>  30
ggattcggca taagcggcaa gcacttcatc acagttacaa cgtttacaag tgcggggaac       60

attggggaag atggaacatt gtcatgtaca tttgagccag atatcaaact caatggaata      120

gtaattcagt ggcttaagga gggcatcaag ggcctggtcc acgaatttaa ggaggggaaa      180

gacgatctgt ctcagcagca cgagatgttc aggggcagaa ccgccgtctt cgcagaccag      240

gttgtggtag gcaacgccag tttgcggctg aaaaacgtgc agctgactga cgccggcacc      300

tacacatgct atatccggtc ctctaagggc aaggggaacg ctaatctcga gtacaaaaca      360

ggcgcctttt ctatgccaga gatcaac                                          387


<210>  31
<211>  387
<212>  DNA
<213>  Mus musculus

<400>  31
ggattcggca taagcggcaa gcacttcatc acagttacaa cgtttacaag tgcggggaac       60

attggggaag atggaacatt gtcatgtaca tttgagccag atatcaaact caatggaata      120

gtaattcagt ggcttaagga gggcatcaag ggcctggtcc acgaatttaa ggaggggaaa      180

gacgatctgt ctcagcagca cgagatgttc aggggcagaa ccgccgtctt cgcagaccag      240

gttgtggtag gcaacgccag tttgcggctg aaaaacgtgc agctgactga cgccggcacc      300

tacacatgct atatccggac ctctaagggc aaggggaacg ctaatctcga gtacaaaaca      360

ggcgcctttt ctatgccaga gatcaac                                          387


<210>  32
<211>  129
<212>  PRT
<213>  Mus musculus

<400>  32

Gly Phe Gly Ile Ser Gly Lys His Phe Ile Thr Val Thr Thr Phe Thr 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Thr Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Asn Gly Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Ile Lys Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Asp Leu Ser 
    50                  55                  60                  


Gln Gln His Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Val Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Thr Cys Tyr Ile Arg Ser Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Ile 
        115                 120                 125             


Asn 
    


<210>  33
<211>  129
<212>  PRT
<213>  Mus musculus

<400>  33

Gly Phe Gly Ile Ser Gly Lys His Phe Ile Thr Val Thr Thr Phe Thr 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Thr Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Asn Gly Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Ile Lys Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Asp Leu Ser 
    50                  55                  60                  


Gln Gln His Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Val Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Thr Cys Tyr Ile Arg Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Ile 
        115                 120                 125             


Asn 
    


<210>  34
<211>  747
<212>  DNA
<213>  Homo sapiens

<400>  34
atggcttccc tggggcagat cctcttctgg agcataatta gcatcatcat tattctggct       60

ggagcaattg cactcatcat tggctttggt atttcaggga gacactccat cacagtcact      120

actgtcgcct cagctgggaa cattggggag gatggaatcc tgagctgcac ttttgaacct      180

gacatcaaac tttctgatat cgtgatacaa tggctgaagg aaggtgtttt aggcttggtc      240

catgagttca aagaaggcaa agatgagctg tcggagcagg atgaaatgtt cagaggccgg      300

acagcagtgt ttgctgatca agtgatagtt ggcaatgcct ctttgcggct gaaaaacgtg      360

caactcacag atgctggcac ctacaaatgt tatatcatca cttctaaagg caaggggaat      420

gctaaccttg agtataaaac tggagccttc agcatgccgg aagtgaatgt ggactataat      480

gccagctcag agaccttgcg gtgtgaggct ccccgatggt tcccccagcc cacagtggtc      540

tgggcatccc aagttgacca gggagccaac ttctcggaag tctccaatac cagctttgag      600

ctgaactctg agaatgtgac catgaaggtt gtgtctgtgc tctacaatgt tacgatcaac      660

aacacatact cctgtatgat tgaaaatgac attgccaaag caacagggga tatcaaagtg      720

acagaatcgg agatcaaaag gcggagt                                          747


<210>  35
<211>  735
<212>  DNA
<213>  Homo sapiens

<400>  35
atggcttccc tggggcagat cctcttctgg agcataatta gcatcatcat tattctggct       60

ggagcaattg cactcatcat tggctttggt atttcaggga gacactccat cacagtcact      120

actgtcgcct cagctgggaa cattggggag gatggaatcc tgagctgcac ttttgaacct      180

gacatcaaac tttctgatat cgtgatacaa tggctgaagg aaggtgtttt aggcttggtc      240

catgagttca aagaaggcaa agatgagctg tcggagcagg atgaaatgtt cagaggccgg      300

acagcagtgt ttgctgatca agtgatagtt ggcaatgcct ctttgcggct gaaaaacgtg      360

caactcacag atgctggcac ctacaaatgt tatatcatca cttctaaagg caaggggaat      420

gctaaccttg agtataaaac tggagccttc agcatgccgg aagtgaatgt ggactataat      480

gccagctcag agaccttgcg gtgtgaggct ccccgatggt tcccccagcc cacagtggtc      540

tgggcatccc aagttgacca gggagccaac ttctcggaag tctccaatac cagctttgag      600

ctgaactctg agaatgtgac catgaaggtt gtgtctgtgc tctacaatgt tacgatcaac      660

aacacatact cctgtatgat tgaaaatgac attgccaaag caacagggga tatcaaagtg      720

acagaatcgg agatc                                                       735


<210>  36
<211>  777
<212>  DNA
<213>  Homo sapiens

<400>  36
atggcttccc tggggcagat cctcttctgg agcataatta gcatcatcat tattctggct       60

ggagcaattg cactcatcat tggctttggt atttcaggga gacactccat cacagtcact      120

actgtcgcct cagctgggaa cattggggag gatggaatcc tgagctgcac ttttgaacct      180

gacatcaaac tttctgatat cgtgatacaa tggctgaagg aaggtgtttt aggcttggtc      240

catgagttca aagaaggcaa agatgagctg tcggagcagg atgaaatgtt cagaggccgg      300

acagcagtgt ttgctgatca agtgatagtt ggcaatgcct ctttgcggct gaaaaacgtg      360

caactcacag atgctggcac ctacaaatgt tatatcatca cttctaaagg caaggggaat      420

gctaaccttg agtataaaac tggagccttc agcatgccgg aagtgaatgt ggactataat      480

gccagctcag agaccttgcg gtgtgaggct ccccgatggt tcccccagcc cacagtggtc      540

tgggcatccc aagttgacca gggagccaac ttctcggaag tctccaatac cagctttgag      600

ctgaactctg agaatgtgac catgaaggtt gtgtctgtgc tctacaatgt tacgatcaac      660

aacacatact cctgtatgat tgaaaatgac attgccaaag caacagggga tatcaaagtg      720

acagaatcgg agatcaaaag gcggagtcac ctacagctgc taaactcaaa ggcttct         777


<210>  37
<211>  723
<212>  DNA
<213>  Homo sapiens

<400>  37
atggaatgga gctgggtatt tctgtttttc ctgtcagtaa cgactggcgt ccattcaggc       60

ttcggcatca gtggacggca cagtatcaca gtgaccaccg tcgcctccgc tggcaatata      120

ggtgaggatg gcatccagtc ctgtaccttt gagccggaca tcaaactgtc tgacatagtg      180

atacaatggc tgaaggaggg ggtgctcggt ctggtacatg agtttaagga agggaaggat      240

gaactgtccg agcaggatga gatgttccgg gggaggaccg ctgtgttcgc cgatcaggta      300

atcgtcggaa atgcaagtct cagattgaaa aatgtgcaac tgactgatgc tggcacgtat      360

aaatgctaca ttatcacaag taagggcaaa ggaaatgcta accttgagta taaaacaggc      420

gcattctcaa tgcccgaggt caatgtcgac tataatgcca gcagtgaaac attgcgctgt      480

gaagctcccc gctggttccc ccagccaacc gtggtctggg cctctcaggt tgatcagggg      540

gctaactttt ccgaggtgag caacaccagc ttcgaactca actctgagaa tgtgaccatg      600

aaagttgtgt ctgtcctgta taatgtaaca atcaacaaca cttattcatg catgattgaa      660

aacgacatcg ccaaggcaac aggtgatatt aaggtaactg aatccgagat caaacggcgg      720

tct                                                                    723


<210>  38
<211>  711
<212>  DNA
<213>  Homo sapiens

<400>  38
atggaatgga gctgggtatt tctgtttttc ctgtcagtaa cgactggcgt ccattcaggc       60

ttcggcatca gtggacggca cagtatcaca gtgaccaccg tcgcctccgc tggcaatata      120

ggtgaggatg gcatccagtc ctgtaccttt gagccggaca tcaaactgtc tgacatagtg      180

atacaatggc tgaaggaggg ggtgctcggt ctggtacatg agtttaagga agggaaggat      240

gaactgtccg agcaggatga gatgttccgg gggaggaccg ctgtgttcgc cgatcaggta      300

atcgtcggaa atgcaagtct cagattgaaa aatgtgcaac tgactgatgc tggcacgtat      360

aaatgctaca ttatcacaag taagggcaaa ggaaatgcta accttgagta taaaacaggc      420

gcattctcaa tgcccgaggt caatgtcgac tataatgcca gcagtgaaac attgcgctgt      480

gaagctcccc gctggttccc ccagccaacc gtggtctggg cctctcaggt tgatcagggg      540

gctaactttt ccgaggtgag caacaccagc ttcgaactca actctgagaa tgtgaccatg      600

aaagttgtgt ctgtcctgta taatgtaaca atcaacaaca cttattcatg catgattgaa      660

aacgacatcg ccaaggcaac aggtgatatt aaggtaactg aatccgagat c               711


<210>  39
<211>  753
<212>  DNA
<213>  Homo sapiens

<400>  39
atggaatgga gctgggtatt tctgtttttc ctgtcagtaa cgactggcgt ccattcaggc       60

ttcggcatca gtggacggca cagtatcaca gtgaccaccg tcgcctccgc tggcaatata      120

ggtgaggatg gcatccagtc ctgtaccttt gagccggaca tcaaactgtc tgacatagtg      180

atacaatggc tgaaggaggg ggtgctcggt ctggtacatg agtttaagga agggaaggat      240

gaactgtccg agcaggatga gatgttccgg gggaggaccg ctgtgttcgc cgatcaggta      300

atcgtcggaa atgcaagtct cagattgaaa aatgtgcaac tgactgatgc tggcacgtat      360

aaatgctaca ttatcacaag taagggcaaa ggaaatgcta accttgagta taaaacaggc      420

gcattctcaa tgcccgaggt caatgtcgac tataatgcca gcagtgaaac attgcgctgt      480

gaagctcccc gctggttccc ccagccaacc gtggtctggg cctctcaggt tgatcagggg      540

gctaactttt ccgaggtgag caacaccagc ttcgaactca actctgagaa tgtgaccatg      600

aaagttgtgt ctgtcctgta taatgtaaca atcaacaaca cttattcatg catgattgaa      660

aacgacatcg ccaaggcaac aggtgatatt aaggtaactg aatccgagat caaacggcgg      720

tctcacctac agctgctaaa ctcaaaggct tct                                   753


<210>  40
<211>  723
<212>  DNA
<213>  Homo sapiens

<400>  40
atggaatgga gctgggtatt tctgtttttc ctgtcagtaa cgactggcgt ccattcaggc       60

ttcggcatca gtggacggca cagtatcaca gtgaccaccg tcgcctccgc tggcaatata      120

ggtgaggatg gcatcctgtc ctgtaccttt gagccggaca tcaaactgtc tgacatagtg      180

atacaatggc tgaaggaggg ggtgctcggt ctggtacatg agtttaagga agggaaggat      240

gaactgtccg agcaggatga gatgttccgg gggaggaccg ctgtgttcgc cgatcaggta      300

atcgtcggaa atgcaagtct cagattgaaa aatgtgcaac tgactgatgc tggcacgtat      360

aaatgctaca ttatcacaag taagggcaaa ggaaatgcta accttgagta taaaacaggc      420

gcattctcaa tgcccgaggt caatgtcgac tataatgcca gcagtgaaac attgcgctgt      480

gaagctcccc gctggttccc ccagccaacc gtggtctggg cctctcaggt tgatcagggg      540

gctaactttt ccgaggtgag caacaccagc ttcgaactca actctgagaa tgtgaccatg      600

aaagttgtgt ctgtcctgta taatgtaaca atcaacaaca cttattcatg catgattgaa      660

aacgacatcg ccaaggcaac aggtgatatt aaggtaactg aatccgagat caaacggcgg      720

tct                                                                    723


<210>  41
<211>  711
<212>  DNA
<213>  Homo sapiens

<400>  41
atggaatgga gctgggtatt tctgtttttc ctgtcagtaa cgactggcgt ccattcaggc       60

ttcggcatca gtggacggca cagtatcaca gtgaccaccg tcgcctccgc tggcaatata      120

ggtgaggatg gcatcctgtc ctgtaccttt gagccggaca tcaaactgtc tgacatagtg      180

atacaatggc tgaaggaggg ggtgctcggt ctggtacatg agtttaagga agggaaggat      240

gaactgtccg agcaggatga gatgttccgg gggaggaccg ctgtgttcgc cgatcaggta      300

atcgtcggaa atgcaagtct cagattgaaa aatgtgcaac tgactgatgc tggcacgtat      360

aaatgctaca ttatcacaag taagggcaaa ggaaatgcta accttgagta taaaacaggc      420

gcattctcaa tgcccgaggt caatgtcgac tataatgcca gcagtgaaac attgcgctgt      480

gaagctcccc gctggttccc ccagccaacc gtggtctggg cctctcaggt tgatcagggg      540

gctaactttt ccgaggtgag caacaccagc ttcgaactca actctgagaa tgtgaccatg      600

aaagttgtgt ctgtcctgta taatgtaaca atcaacaaca cttattcatg catgattgaa      660

aacgacatcg ccaaggcaac aggtgatatt aaggtaactg aatccgagat c               711


<210>  42
<211>  753
<212>  DNA
<213>  Homo sapiens

<400>  42
atggaatgga gctgggtatt tctgtttttc ctgtcagtaa cgactggcgt ccattcaggc       60

ttcggcatca gtggacggca cagtatcaca gtgaccaccg tcgcctccgc tggcaatata      120

ggtgaggatg gcatcctgtc ctgtaccttt gagccggaca tcaaactgtc tgacatagtg      180

atacaatggc tgaaggaggg ggtgctcggt ctggtacatg agtttaagga agggaaggat      240

gaactgtccg agcaggatga gatgttccgg gggaggaccg ctgtgttcgc cgatcaggta      300

atcgtcggaa atgcaagtct cagattgaaa aatgtgcaac tgactgatgc tggcacgtat      360

aaatgctaca ttatcacaag taagggcaaa ggaaatgcta accttgagta taaaacaggc      420

gcattctcaa tgcccgaggt caatgtcgac tataatgcca gcagtgaaac attgcgctgt      480

gaagctcccc gctggttccc ccagccaacc gtggtctggg cctctcaggt tgatcagggg      540

gctaactttt ccgaggtgag caacaccagc ttcgaactca actctgagaa tgtgaccatg      600

aaagttgtgt ctgtcctgta taatgtaaca atcaacaaca cttattcatg catgattgaa      660

aacgacatcg ccaaggcaac aggtgatatt aaggtaactg aatccgagat caaacggcgg      720

tctcacctac agctgctaaa ctcaaaggct tct                                   753


<210>  43
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Gln Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser 
    


<210>  44
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  44

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Gln Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile 
225                 230                 235         


<210>  45
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  45

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Gln Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser His Leu Gln Leu Leu Asn Ser Lys Ala Ser 
                245                 250     


<210>  46
<211>  241
<212>  PRT
<213>  Homo sapiens

<400>  46

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser 
    


<210>  47
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  47

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile 
225                 230                 235         


<210>  48
<211>  251
<212>  PRT
<213>  Homo sapiens

<400>  48

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser His Leu Gln Leu Leu Asn Ser Lys Ala Ser 
                245                 250     


<210>  49
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  49

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Gln Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser 
                245                 


<210>  50
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  50

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Gln Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile 
                245 


<210>  51
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Gln Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Lys Ala Ser 
            


<210>  52
<211>  249
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser 
                245                 


<210>  53
<211>  245
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile 
                245 


<210>  54
<211>  259
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Lys Ala Ser 
            


<210>  55
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  55

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Gln Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser 
    210                 215                 220         


<210>  56
<211>  222
<212>  PRT
<213>  Homo sapiens

<400>  56

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser 
    210                 215                 220         


<210>  57
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  57

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Gln Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile 
    210                 215             


<210>  58
<211>  218
<212>  PRT
<213>  Homo sapiens

<400>  58

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile 
    210                 215             


<210>  59
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  59

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Gln Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu 
    210                 215                 220                 


Gln Leu Leu Asn Ser Lys Ala Ser 
225                 230         


<210>  60
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  60

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu 
    210                 215                 220                 


Gln Leu Leu Asn Ser Lys Ala Ser 
225                 230         


<210>  61
<211>  387
<212>  DNA
<213>  Homo sapiens

<400>  61
ggcttcggca tcagtggacg gcacagtatc acagtgacca ccgtcgcctc cgctggcaat       60

ataggtgagg atggcatcca gtcctgtacc tttgagccgg acatcaaact gtctgacata      120

gtgatacaat ggctgaagga gggggtgctc ggtctggtac atgagtttaa ggaagggaag      180

gatgaactgt ccgagcagga tgagatgttc cgggggagga ccgctgtgtt cgccgatcag      240

gtaatcgtcg gaaatgcaag tctcagattg aaaaatgtgc aactgactga tgctggcacg      300

tataaatgct acattatcac aagtaagggc aaaggaaatg ctaaccttga gtataaaaca      360

ggcgcattct caatgcccga ggtcaat                                          387


<210>  62
<211>  387
<212>  DNA
<213>  Homo sapiens

<400>  62
ggcttcggca tcagtggacg gcacagtatc acagtgacca ccgtcgcctc cgctggcaat       60

ataggtgagg atggcatcct gtcctgtacc tttgagccgg acatcaaact gtctgacata      120

gtgatacaat ggctgaagga gggggtgctc ggtctggtac atgagtttaa ggaagggaag      180

gatgaactgt ccgagcagga tgagatgttc cgggggagga ccgctgtgtt cgccgatcag      240

gtaatcgtcg gaaatgcaag tctcagattg aaaaatgtgc aactgactga tgctggcacg      300

tataaatgct acattatcac aagtaagggc aaaggaaatg ctaaccttga gtataaaaca      360

ggcgcattct caatgcccga ggtcaat                                          387


<210>  63
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  63

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Gln Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn 
    


<210>  64
<211>  129
<212>  PRT
<213>  Homo sapiens

<400>  64

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn 
    


<210>  65
<211>  245
<212>  PRT
<213>  Pan troglodytes

<400>  65

Met Lys Pro Leu Thr Ser Arg Ile Ile Ser Ile Ile Ile Ile Leu Ala 
1               5                   10                  15      


Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser Gly Arg His Ser 
            20                  25                  30          


Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly 
        35                  40                  45              


Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val 
    50                  55                  60                  


Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys 
65                  70                  75                  80  


Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg 
                85                  90                  95      


Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg 
            100                 105                 110         


Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile 
        115                 120                 125             


Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly 
    130                 135                 140                 


Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu 
145                 150                 155                 160 


Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val 
                165                 170                 175     


Trp Ala Ser Gln Ile Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn 
            180                 185                 190         


Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser 
        195                 200                 205             


Val Leu Tyr Asn Ala Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu 
    210                 215                 220                 


Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu 
225                 230                 235                 240 


Ile Lys Arg Arg Ser 
                245 


<210>  66
<211>  241
<212>  PRT
<213>  Pan troglodytes

<400>  66

Met Lys Pro Leu Thr Ser Arg Ile Ile Ser Ile Ile Ile Ile Leu Ala 
1               5                   10                  15      


Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser Gly Arg His Ser 
            20                  25                  30          


Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly 
        35                  40                  45              


Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val 
    50                  55                  60                  


Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys 
65                  70                  75                  80  


Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg 
                85                  90                  95      


Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg 
            100                 105                 110         


Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile 
        115                 120                 125             


Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly 
    130                 135                 140                 


Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu 
145                 150                 155                 160 


Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val 
                165                 170                 175     


Trp Ala Ser Gln Ile Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn 
            180                 185                 190         


Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser 
        195                 200                 205             


Val Leu Tyr Asn Ala Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu 
    210                 215                 220                 


Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu 
225                 230                 235                 240 


Ile 
    


<210>  67
<211>  255
<212>  PRT
<213>  Pan troglodytes

<400>  67

Met Lys Pro Leu Thr Ser Arg Ile Ile Ser Ile Ile Ile Ile Leu Ala 
1               5                   10                  15      


Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser Gly Arg His Ser 
            20                  25                  30          


Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly 
        35                  40                  45              


Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val 
    50                  55                  60                  


Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys 
65                  70                  75                  80  


Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg 
                85                  90                  95      


Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg 
            100                 105                 110         


Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile 
        115                 120                 125             


Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly 
    130                 135                 140                 


Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu 
145                 150                 155                 160 


Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val 
                165                 170                 175     


Trp Ala Ser Gln Ile Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn 
            180                 185                 190         


Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser 
        195                 200                 205             


Val Leu Tyr Asn Ala Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu 
    210                 215                 220                 


Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu 
225                 230                 235                 240 


Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser Lys Ala Ser 
                245                 250                 255 


<210>  68
<211>  222
<212>  PRT
<213>  Pan troglodytes

<400>  68

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Ile Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Ala Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser 
    210                 215                 220         


<210>  69
<211>  218
<212>  PRT
<213>  Pan troglodytes

<400>  69

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Ile Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Ala Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile 
    210                 215             


<210>  70
<211>  232
<212>  PRT
<213>  Macaca mulatta

<400>  70

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Ile Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Ala Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu 
    210                 215                 220                 


Gln Leu Leu Asn Ser Lys Ala Ser 
225                 230         


<210>  71
<211>  249
<212>  PRT
<213>  Macaca mulatta

<400>  71

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Phe Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Ile Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser 
                245                 


<210>  72
<211>  245
<212>  PRT
<213>  Macaca mulatta

<400>  72

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Phe Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Ile Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile 
                245 


<210>  73
<211>  259
<212>  PRT
<213>  Macaca mulatta

<400>  73

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Phe Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Ile Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Lys Ala Ser 
            


<210>  74
<211>  222
<212>  PRT
<213>  Macaca mulatta

<400>  74

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Ile Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser 
    210                 215                 220         


<210>  75
<211>  218
<212>  PRT
<213>  Macaca mulatta

<400>  75

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Ile Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile 
    210                 215             


<210>  76
<211>  232
<212>  PRT
<213>  Macaca fascicularis

<400>  76

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Ile Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu 
    210                 215                 220                 


Gln Leu Leu Asn Ser Lys Ala Ser 
225                 230         


<210>  77
<211>  249
<212>  PRT
<213>  Macaca fascicularis

<400>  77

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Phe Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Ile Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser 
                245                 


<210>  78
<211>  245
<212>  PRT
<213>  Macaca fascicularis

<400>  78

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Phe Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Ile Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile 
                245 


<210>  79
<211>  259
<212>  PRT
<213>  Macaca fascicularis

<400>  79

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Phe Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Ile Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Lys Ala Ser 
            


<210>  80
<211>  222
<212>  PRT
<213>  Macaca fascicularis

<400>  80

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Ile Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser 
    210                 215                 220         


<210>  81
<211>  218
<212>  PRT
<213>  Macaca fascicularis

<400>  81

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Ile Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile 
    210                 215             


<210>  82
<211>  232
<212>  PRT
<213>  Macaca fascicularis

<400>  82

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Ile Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu 
    210                 215                 220                 


Gln Leu Leu Asn Ser Lys Ala Ser 
225                 230         


<210>  83
<211>  129
<212>  PRT
<213>  Pan troglodytes

<400>  83

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn 
    


<210>  84
<211>  129
<212>  PRT
<213>  Macaca mulatta

<400>  84

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Ile Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn 
    


<210>  85
<211>  129
<212>  PRT
<213>  Macaca fascicularis

<400>  85

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Ile Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn 
    


<210>  86
<211>  696
<212>  DNA
<213>  Homo sapiens

<400>  86
gagcctaagt catgtgacaa gacccatacg tgcccaccct gtcccgctcc agaactgctg       60

gggggaccta gcgttttctt gttcccccca aagcccaagg acaccctcat gatctcacgg      120

actcccgaag taacatgcgt agtagtcgac gtgagccacg aggatcctga agtgaagttt      180

aattggtacg tggacggagt cgaggtgcat aatgccaaaa ctaaacctcg ggaggagcag      240

tataacagta cctaccgcgt ggtatccgtc ttgacagtgc tccaccagga ctggctgaat      300

ggtaaggagt ataaatgcaa ggtcagcaac aaagctcttc ccgccccaat tgaaaagact      360

atcagcaagg ccaagggaca accccgcgag ccccaggttt acacccttcc accttcacga      420

gacgagctga ccaagaacca ggtgtctctg acttgtctgg tcaaaggttt ctatccttcc      480

gacatcgcag tggagtggga gtcaaacggg cagcctgaga ataactacaa gaccacaccc      540

ccagtgcttg atagcgatgg gagctttttc ctctacagta agctgactgt ggacaaatcc      600

cgctggcagc agggaaacgt tttctcttgt agcgtcatgc atgaggccct ccacaaccat      660

tatactcaga aaagcctgag tctgagtccc ggcaaa                                696


<210>  87
<211>  681
<212>  DNA
<213>  Homo sapiens

<400>  87
gacaagaccc atacgtgccc accctgtccc gctccagaac tgctgggggg acctagcgtt       60

ttcttgttcc ccccaaagcc caaggacacc ctcatgatct cacggactcc cgaagtaaca      120

tgcgtagtag tcgacgtgag ccacgaggat cctgaagtga agtttaattg gtacgtggac      180

ggagtcgagg tgcataatgc caaaactaaa cctcgggagg agcagtataa cagtacctac      240

cgcgtggtat ccgtcttgac agtgctccac caggactggc tgaatggtaa ggagtataaa      300

tgcaaggtca gcaacaaagc tcttcccgcc ccaattgaaa agactatcag caaggccaag      360

ggacaacccc gcgagcccca ggtttacacc cttccacctt cacgagacga gctgaccaag      420

aaccaggtgt ctctgacttg tctggtcaaa ggtttctatc cttccgacat cgcagtggag      480

tgggagtcaa acgggcagcc tgagaataac tacaagacca cacccccagt gcttgatagc      540

gatgggagct ttttcctcta cagtaagctg actgtggaca aatcccgctg gcagcaggga      600

aacgttttct cttgtagcgt catgcatgag gccctccaca accattatac tcagaaaagc      660

ctgagtctga gtcccggcaa a                                                681


<210>  88
<211>  232
<212>  PRT
<213>  Homo sapiens

<400>  88

Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
1               5                   10                  15      


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            20                  25                  30          


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        35                  40                  45              


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    50                  55                  60                  


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
65                  70                  75                  80  


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                85                  90                  95      


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            100                 105                 110         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        115                 120                 125             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    130                 135                 140                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
145                 150                 155                 160 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                165                 170                 175     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            180                 185                 190         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        195                 200                 205             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    210                 215                 220                 


Ser Leu Ser Leu Ser Pro Gly Lys 
225                 230         


<210>  89
<211>  227
<212>  PRT
<213>  Homo sapiens

<400>  89

Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly 
1               5                   10                  15      


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            20                  25                  30          


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His 
        35                  40                  45              


Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    50                  55                  60                  


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr 
65                  70                  75                  80  


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                85                  90                  95      


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile 
            100                 105                 110         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        115                 120                 125             


Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser 
    130                 135                 140                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
145                 150                 155                 160 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                165                 170                 175     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val 
            180                 185                 190         


Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met 
        195                 200                 205             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    210                 215                 220                 


Pro Gly Lys 
225         


<210>  90
<211>  699
<212>  DNA
<213>  Mus musculus

<400>  90
gagccaagag gtcctacgat caagccctgc ccgccttgta aatgcccagc tccaaatttg       60

ctgggtggac cgtcagtctt tatcttcccg ccaaagataa aggacgtctt gatgattagt      120

ctgagcccca tcgtgacatg cgttgtggtg gatgtttcag aggatgaccc cgacgtgcaa      180

atcagttggt tcgttaacaa cgtggaggtg cataccgctc aaacccagac ccacagagag      240

gattataaca gcaccctgcg ggtagtgtcc gccctgccga tccagcatca ggattggatg      300

agcgggaaag agttcaagtg taaggtaaac aacaaagatc tgccagcgcc gattgaacga      360

accattagca agccgaaagg gagcgtgcgc gcacctcagg tttacgtcct tcctccacca      420

gaagaggaga tgacgaaaaa gcaggtgacc ctgacatgca tggtaactga ctttatgcca      480

gaagatattt acgtggaatg gactaataac ggaaagacag agctcaatta caagaacact      540

gagcctgttc tggattctga tggcagctac tttatgtact ccaaattgag ggtcgagaag      600

aagaattggg tcgagagaaa cagttatagt tgctcagtgg tgcatgaggg cctccataat      660

catcacacca caaagtcctt cagccgaacg cccgggaaa                             699


<210>  91
<211>  233
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  91

Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys Pro 
1               5                   10                  15      


Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro Lys 
            20                  25                  30          


Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys Val 
        35                  40                  45              


Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp Phe 
    50                  55                  60                  


Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg Glu 
65                  70                  75                  80  


Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln His 
                85                  90                  95      


Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn Lys 
            100                 105                 110         


Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly Ser 
        115                 120                 125             


Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu Met 
    130                 135                 140                 


Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met Pro 
145                 150                 155                 160 


Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu Asn 
                165                 170                 175     


Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe Met 
            180                 185                 190         


Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn Ser 
        195                 200                 205             


Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr Thr 
    210                 215                 220                 


Lys Ser Phe Ser Arg Thr Pro Gly Lys 
225                 230             


<210>  92
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker sequence

<400>  92

Asp Ser Gly Ser 
1               


<210>  93
<211>  4
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker peptide

<400>  93

Gly Gly Gly Ser 
1               


<210>  94
<211>  15
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker peptide

<400>  94

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15  


<210>  95
<211>  20
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic linker peptide

<400>  95

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser 
            20  


<210>  96
<211>  1470
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion nucleotide

<400>  96
atggcttcct tggggcagat catcttttgg agtattatta acatcatcat catcctggct       60

ggggccatcg cactcatcat tggctttggc atttcaggca agcacttcat cacggtcacg      120

accttcacct cagctggaaa cattggagag gacgggaccc tgagctgcac ttttgaacct      180

gacatcaaac tcaacggcat cgtcatccag tggctgaaag aaggcatcaa aggtttggtc      240

cacgagttca aagaaggcaa agacgacctc tcacagcagc atgagatgtt cagaggccgc      300

acagcagtgt ttgctgatca ggtggtagtt ggcaatgctt ccctgagact gaaaaacgtg      360

cagctcacgg atgctggcac ctacacatgt tacatccgca cctcaaaagg caaagggaat      420

gcaaaccttg agtataagac cggagccttc agtatgccag agataaatgt ggactataat      480

gccagttcag agagtttacg ctgcgaggct cctcggtggt tcccccagcc cacagtggcc      540

tgggcatctc aagtcgacca aggagccaat ttctcagaag tctccaacac cagctttgag      600

ttgaactctg agaatgtgac catgaaggtc gtatctgtgc tctacaatgt cacaatcaac      660

aacacatact cctgtatgat tgaaaacgac attgccaaag ccaccgggga catcaaagtg      720

acagattcag aggtcaaaag gcgaagtcag ctgcagttgc tgaactctgg ggagccaaga      780

ggtcctacga tcaagccctg cccgccttgt aaatgcccag ctccaaattt gctgggtgga      840

ccgtcagtct ttatcttccc gccaaagata aaggacgtct tgatgattag tctgagcccc      900

atcgtgacat gcgttgtggt ggatgtttca gaggatgacc ccgacgtgca aatcagttgg      960

ttcgttaaca acgtggaggt gcataccgct caaacccaga cccacagaga ggattataac     1020

agcaccctgc gggtagtgtc cgccctgccg atccagcatc aggattggat gagcgggaaa     1080

gagttcaagt gtaaggtaaa caacaaagat ctgccagcgc cgattgaacg aaccattagc     1140

aagccgaaag ggagcgtgcg cgcacctcag gtttacgtcc ttcctccacc agaagaggag     1200

atgacgaaaa agcaggtgac cctgacatgc atggtaactg actttatgcc agaagatatt     1260

tacgtggaat ggactaataa cggaaagaca gagctcaatt acaagaacac tgagcctgtt     1320

ctggattctg atggcagcta ctttatgtac tccaaattga gggtcgagaa gaagaattgg     1380

gtcgagagaa acagttatag ttgctcagtg gtgcatgagg gcctccataa tcatcacacc     1440

acaaagtcct tcagccgaac gcccgggaaa                                      1470


<210>  97
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion nucleotide

<400>  97
atggagtggt catgggtttt tctgttcttt cttagcgtga ctacaggcgt ccattcagga       60

ttcggcataa gcggcaagca cttcatcaca gttacaacgt ttacaagtgc ggggaacatt      120

ggggaagatg gaacattgtc atgtacattt gagccagata tcaaactcaa tggaatagta      180

attcagtggc ttaaggaggg catcaagggc ctggtccacg aatttaagga ggggaaagac      240

gatctgtctc agcagcacga gatgttcagg ggcagaaccg ccgtcttcgc agaccaggtt      300

gtggtaggca acgccagttt gcggctgaaa aacgtgcagc tgactgacgc cggcacctac      360

acatgctata tccggtcctc taagggcaag gggaacgcta atctcgagta caaaacaggc      420

gccttttcta tgccagagat caacgtggac tataacgcaa gctctgaaag tctgagatgc      480

gaggcgccaa ggtggttccc tcagcccacc gtcgcgtggg cttcccaggt ggatcaaggc      540

gccaactttt ctgaggtttc taacaccagc ttcgaactga acagcgaaaa tgtgacaatg      600

aaggtagtca gcgttctgta taacgtgacc atcaacaata cttactcctg tatgatagaa      660

aatgatatag ccaaggctac aggagatatt aaagtgacgg attcagaagt gaaaaggagg      720

agtcaactgc aactcttgaa tagcggcgag ccaagaggtc ctacgatcaa gccctgcccg      780

ccttgtaaat gcccagctcc aaatttgctg ggtggaccgt cagtctttat cttcccgcca      840

aagataaagg acgtcttgat gattagtctg agccccatcg tgacatgcgt tgtggtggat      900

gtttcagagg atgaccccga cgtgcaaatc agttggttcg ttaacaacgt ggaggtgcat      960

accgctcaaa cccagaccca cagagaggat tataacagca ccctgcgggt agtgtccgcc     1020

ctgccgatcc agcatcagga ttggatgagc gggaaagagt tcaagtgtaa ggtaaacaac     1080

aaagatctgc cagcgccgat tgaacgaacc attagcaagc cgaaagggag cgtgcgcgca     1140

cctcaggttt acgtccttcc tccaccagaa gaggagatga cgaaaaagca ggtgaccctg     1200

acatgcatgg taactgactt tatgccagaa gatatttacg tggaatggac taataacgga     1260

aagacagagc tcaattacaa gaacactgag cctgttctgg attctgatgg cagctacttt     1320

atgtactcca aattgagggt cgagaagaag aattgggtcg agagaaacag ttatagttgc     1380

tcagtggtgc atgagggcct ccataatcat cacaccacaa agtccttcag ccgaacgccc     1440

gggaaa                                                                1446


<210>  98
<211>  1446
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion nucleotide

<400>  98
atggagtggt catgggtttt tctgttcttt cttagcgtga ctacaggcgt ccattcagga       60

ttcggcataa gcggcaagca cttcatcaca gttacaacgt ttacaagtgc ggggaacatt      120

ggggaagatg gaacattgtc atgtacattt gagccagata tcaaactcaa tggaatagta      180

attcagtggc ttaaggaggg catcaagggc ctggtccacg aatttaagga ggggaaagac      240

gatctgtctc agcagcacga gatgttcagg ggcagaaccg ccgtcttcgc agaccaggtt      300

gtggtaggca acgccagttt gcggctgaaa aacgtgcagc tgactgacgc cggcacctac      360

acatgctata tccggacctc taagggcaag gggaacgcta atctcgagta caaaacaggc      420

gccttttcta tgccagagat caacgtggac tataacgcaa gctctgaaag tctgagatgc      480

gaggcgccaa ggtggttccc tcagcccacc gtcgcgtggg cttcccaggt ggatcaaggc      540

gccaactttt ctgaggtttc taacaccagc ttcgaactga acagcgaaaa tgtgacaatg      600

aaggtagtca gcgttctgta taacgtgacc atcaacaata cttactcctg tatgatagaa      660

aatgatatag ccaaggctac aggagatatt aaagtgacgg attcagaagt gaaaaggagg      720

agtcaactgc aactcttgaa tagcggcgag ccaagaggtc ctacgatcaa gccctgcccg      780

ccttgtaaat gcccagctcc aaatttgctg ggtggaccgt cagtctttat cttcccgcca      840

aagataaagg acgtcttgat gattagtctg agccccatcg tgacatgcgt tgtggtggat      900

gtttcagagg atgaccccga cgtgcaaatc agttggttcg ttaacaacgt ggaggtgcat      960

accgctcaaa cccagaccca cagagaggat tataacagca ccctgcgggt agtgtccgcc     1020

ctgccgatcc agcatcagga ttggatgagc gggaaagagt tcaagtgtaa ggtaaacaac     1080

aaagatctgc cagcgccgat tgaacgaacc attagcaagc cgaaagggag cgtgcgcgca     1140

cctcaggttt acgtccttcc tccaccagaa gaggagatga cgaaaaagca ggtgaccctg     1200

acatgcatgg taactgactt tatgccagaa gatatttacg tggaatggac taataacgga     1260

aagacagagc tcaattacaa gaacactgag cctgttctgg attctgatgg cagctacttt     1320

atgtactcca aattgagggt cgagaagaag aattgggtcg agagaaacag ttatagttgc     1380

tcagtggtgc atgagggcct ccataatcat cacaccacaa agtccttcag ccgaacgccc     1440

gggaaa                                                                1446


<210>  99
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  99

Met Ala Ser Leu Gly Gln Ile Ile Phe Trp Ser Ile Ile Asn Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Lys His Phe Ile Thr Val Thr Thr Phe Thr Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Thr Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Asn Gly Ile Val Ile Gln Trp Leu Lys Glu Gly Ile Lys Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Asp Leu Ser Gln Gln His Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Val Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Thr Cys Tyr Ile Arg Ser Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Ile Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Ser Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Ala Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Asp Ser Glu Val Lys Arg Arg Ser Gln Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Gly Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys 
            260                 265                 270         


Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
        275                 280                 285             


Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys 
    290                 295                 300                 


Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 
305                 310                 315                 320 


Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 
                325                 330                 335     


Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 
            340                 345                 350         


His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
        355                 360                 365             


Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
    370                 375                 380                 


Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 
385                 390                 395                 400 


Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 
                405                 410                 415     


Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
            420                 425                 430         


Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 
        435                 440                 445             


Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 
    450                 455                 460                 


Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 
465                 470                 475                 480 


Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                485                 490 


<210>  100
<211>  490
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  100

Met Ala Ser Leu Gly Gln Ile Ile Phe Trp Ser Ile Ile Asn Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Lys His Phe Ile Thr Val Thr Thr Phe Thr Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Thr Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Asn Gly Ile Val Ile Gln Trp Leu Lys Glu Gly Ile Lys Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Asp Leu Ser Gln Gln His Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Val Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Thr Cys Tyr Ile Arg Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Ile Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Ser Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Ala Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Asp Ser Glu Val Lys Arg Arg Ser Gln Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Gly Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys Pro Pro Cys Lys Cys 
            260                 265                 270         


Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val Phe Ile Phe Pro Pro 
        275                 280                 285             


Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser Pro Ile Val Thr Cys 
    290                 295                 300                 


Val Val Val Asp Val Ser Glu Asp Asp Pro Asp Val Gln Ile Ser Trp 
305                 310                 315                 320 


Phe Val Asn Asn Val Glu Val His Thr Ala Gln Thr Gln Thr His Arg 
                325                 330                 335     


Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser Ala Leu Pro Ile Gln 
            340                 345                 350         


His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys Cys Lys Val Asn Asn 
        355                 360                 365             


Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile Ser Lys Pro Lys Gly 
    370                 375                 380                 


Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro Pro Pro Glu Glu Glu 
385                 390                 395                 400 


Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met Val Thr Asp Phe Met 
                405                 410                 415     


Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn Gly Lys Thr Glu Leu 
            420                 425                 430         


Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser Asp Gly Ser Tyr Phe 
        435                 440                 445             


Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn Trp Val Glu Arg Asn 
    450                 455                 460                 


Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu His Asn His His Thr 
465                 470                 475                 480 


Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
                485                 490 


<210>  101
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  101

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Lys His Phe Ile Thr Val Thr 
            20                  25                  30          


Thr Phe Thr Ser Ala Gly Asn Ile Gly Glu Asp Gly Thr Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Asn Gly Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Ile Lys Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Asp Leu Ser Gln Gln His Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Val Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Thr Cys Tyr Ile Arg Ser Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Ile Asn Val Asp Tyr Asn Ala Ser Ser Glu Ser Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Ala Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Asp Ser Glu Val Lys Arg Arg 
225                 230                 235                 240 


Ser Gln Leu Gln Leu Leu Asn Ser Gly Glu Pro Arg Gly Pro Thr Ile 
                245                 250                 255     


Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly 
            260                 265                 270         


Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile 
        275                 280                 285             


Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp 
    290                 295                 300                 


Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His 
305                 310                 315                 320 


Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg 
                325                 330                 335     


Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys 
            340                 345                 350         


Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr 
    370                 375                 380                 


Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu 
385                 390                 395                 400 


Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp 
                405                 410                 415     


Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu 
        435                 440                 445             


Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His 
    450                 455                 460                 


Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro 
465                 470                 475                 480 


Gly Lys 
        


<210>  102
<211>  482
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  102

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Lys His Phe Ile Thr Val Thr 
            20                  25                  30          


Thr Phe Thr Ser Ala Gly Asn Ile Gly Glu Asp Gly Thr Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Asn Gly Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Ile Lys Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Asp Leu Ser Gln Gln His Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Val Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Thr Cys Tyr Ile Arg Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Ile Asn Val Asp Tyr Asn Ala Ser Ser Glu Ser Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Ala Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Asp Ser Glu Val Lys Arg Arg 
225                 230                 235                 240 


Ser Gln Leu Gln Leu Leu Asn Ser Gly Glu Pro Arg Gly Pro Thr Ile 
                245                 250                 255     


Lys Pro Cys Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly 
            260                 265                 270         


Pro Ser Val Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile 
        275                 280                 285             


Ser Leu Ser Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp 
    290                 295                 300                 


Asp Pro Asp Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His 
305                 310                 315                 320 


Thr Ala Gln Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg 
                325                 330                 335     


Val Val Ser Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys 
            340                 345                 350         


Glu Phe Lys Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu 
        355                 360                 365             


Arg Thr Ile Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr 
    370                 375                 380                 


Val Leu Pro Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu 
385                 390                 395                 400 


Thr Cys Met Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp 
                405                 410                 415     


Thr Asn Asn Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val 
            420                 425                 430         


Leu Asp Ser Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu 
        435                 440                 445             


Lys Lys Asn Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His 
    450                 455                 460                 


Glu Gly Leu His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro 
465                 470                 475                 480 


Gly Lys 
        


<210>  103
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  103

Gly Phe Gly Ile Ser Gly Lys His Phe Ile Thr Val Thr Thr Phe Thr 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Thr Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Asn Gly Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Ile Lys Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Asp Leu Ser 
    50                  55                  60                  


Gln Gln His Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Val Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Thr Cys Tyr Ile Arg Ser Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Ile 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Ser Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Ala Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Asp Ser Glu Val Lys Arg Arg Ser Gln Leu 
    210                 215                 220                 


Gln Leu Leu Asn Ser Gly Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys 
225                 230                 235                 240 


Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser 
            260                 265                 270         


Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp 
        275                 280                 285             


Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln 
    290                 295                 300                 


Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser 
305                 310                 315                 320 


Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys 
                325                 330                 335     


Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile 
            340                 345                 350         


Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro 
        355                 360                 365             


Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met 
    370                 375                 380                 


Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn 
385                 390                 395                 400 


Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn 
            420                 425                 430         


Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu 
        435                 440                 445             


His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
    450                 455                 460             


<210>  104
<211>  463
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  104

Gly Phe Gly Ile Ser Gly Lys His Phe Ile Thr Val Thr Thr Phe Thr 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Thr Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Asn Gly Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Ile Lys Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Asp Leu Ser 
    50                  55                  60                  


Gln Gln His Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Val Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Thr Cys Tyr Ile Arg Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Ile 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Ser Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Ala Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Asp Ser Glu Val Lys Arg Arg Ser Gln Leu 
    210                 215                 220                 


Gln Leu Leu Asn Ser Gly Glu Pro Arg Gly Pro Thr Ile Lys Pro Cys 
225                 230                 235                 240 


Pro Pro Cys Lys Cys Pro Ala Pro Asn Leu Leu Gly Gly Pro Ser Val 
                245                 250                 255     


Phe Ile Phe Pro Pro Lys Ile Lys Asp Val Leu Met Ile Ser Leu Ser 
            260                 265                 270         


Pro Ile Val Thr Cys Val Val Val Asp Val Ser Glu Asp Asp Pro Asp 
        275                 280                 285             


Val Gln Ile Ser Trp Phe Val Asn Asn Val Glu Val His Thr Ala Gln 
    290                 295                 300                 


Thr Gln Thr His Arg Glu Asp Tyr Asn Ser Thr Leu Arg Val Val Ser 
305                 310                 315                 320 


Ala Leu Pro Ile Gln His Gln Asp Trp Met Ser Gly Lys Glu Phe Lys 
                325                 330                 335     


Cys Lys Val Asn Asn Lys Asp Leu Pro Ala Pro Ile Glu Arg Thr Ile 
            340                 345                 350         


Ser Lys Pro Lys Gly Ser Val Arg Ala Pro Gln Val Tyr Val Leu Pro 
        355                 360                 365             


Pro Pro Glu Glu Glu Met Thr Lys Lys Gln Val Thr Leu Thr Cys Met 
    370                 375                 380                 


Val Thr Asp Phe Met Pro Glu Asp Ile Tyr Val Glu Trp Thr Asn Asn 
385                 390                 395                 400 


Gly Lys Thr Glu Leu Asn Tyr Lys Asn Thr Glu Pro Val Leu Asp Ser 
                405                 410                 415     


Asp Gly Ser Tyr Phe Met Tyr Ser Lys Leu Arg Val Glu Lys Lys Asn 
            420                 425                 430         


Trp Val Glu Arg Asn Ser Tyr Ser Cys Ser Val Val His Glu Gly Leu 
        435                 440                 445             


His Asn His His Thr Thr Lys Ser Phe Ser Arg Thr Pro Gly Lys 
    450                 455                 460             


<210>  105
<211>  1443
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  105

Ala Thr Gly Gly Cys Thr Thr Cys Cys Cys Thr Gly Gly Gly Gly Cys 
1               5                   10                  15      


Ala Gly Ala Thr Cys Cys Thr Cys Thr Thr Cys Thr Gly Gly Ala Gly 
            20                  25                  30          


Cys Ala Thr Ala Ala Thr Thr Ala Gly Cys Ala Thr Cys Ala Thr Cys 
        35                  40                  45              


Ala Thr Thr Ala Thr Thr Cys Thr Gly Gly Cys Thr Gly Gly Ala Gly 
    50                  55                  60                  


Cys Ala Ala Thr Thr Gly Cys Ala Cys Thr Cys Ala Thr Cys Ala Thr 
65                  70                  75                  80  


Thr Gly Gly Cys Thr Thr Thr Gly Gly Thr Ala Thr Thr Thr Cys Ala 
                85                  90                  95      


Gly Gly Gly Ala Gly Ala Cys Ala Cys Thr Cys Cys Ala Thr Cys Ala 
            100                 105                 110         


Cys Ala Gly Thr Cys Ala Cys Thr Ala Cys Thr Gly Thr Cys Gly Cys 
        115                 120                 125             


Cys Thr Cys Ala Gly Cys Thr Gly Gly Gly Ala Ala Cys Ala Thr Thr 
    130                 135                 140                 


Gly Gly Gly Gly Ala Gly Gly Ala Thr Gly Gly Ala Ala Thr Cys Cys 
145                 150                 155                 160 


Thr Gly Ala Gly Cys Thr Gly Cys Ala Cys Thr Thr Thr Thr Gly Ala 
                165                 170                 175     


Ala Cys Cys Thr Gly Ala Cys Ala Thr Cys Ala Ala Ala Cys Thr Thr 
            180                 185                 190         


Thr Cys Thr Gly Ala Thr Ala Thr Cys Gly Thr Gly Ala Thr Ala Cys 
        195                 200                 205             


Ala Ala Thr Gly Gly Cys Thr Gly Ala Ala Gly Gly Ala Ala Gly Gly 
    210                 215                 220                 


Thr Gly Thr Thr Thr Thr Ala Gly Gly Cys Thr Thr Gly Gly Thr Cys 
225                 230                 235                 240 


Cys Ala Thr Gly Ala Gly Thr Thr Cys Ala Ala Ala Gly Ala Ala Gly 
                245                 250                 255     


Gly Cys Ala Ala Ala Gly Ala Thr Gly Ala Gly Cys Thr Gly Thr Cys 
            260                 265                 270         


Gly Gly Ala Gly Cys Ala Gly Gly Ala Thr Gly Ala Ala Ala Thr Gly 
        275                 280                 285             


Thr Thr Cys Ala Gly Ala Gly Gly Cys Cys Gly Gly Ala Cys Ala Gly 
    290                 295                 300                 


Cys Ala Gly Thr Gly Thr Thr Thr Gly Cys Thr Gly Ala Thr Cys Ala 
305                 310                 315                 320 


Ala Gly Thr Gly Ala Thr Ala Gly Thr Thr Gly Gly Cys Ala Ala Thr 
                325                 330                 335     


Gly Cys Cys Thr Cys Thr Thr Thr Gly Cys Gly Gly Cys Thr Gly Ala 
            340                 345                 350         


Ala Ala Ala Ala Cys Gly Thr Gly Cys Ala Ala Cys Thr Cys Ala Cys 
        355                 360                 365             


Ala Gly Ala Thr Gly Cys Thr Gly Gly Cys Ala Cys Cys Thr Ala Cys 
    370                 375                 380                 


Ala Ala Ala Thr Gly Thr Thr Ala Thr Ala Thr Cys Ala Thr Cys Ala 
385                 390                 395                 400 


Cys Thr Thr Cys Thr Ala Ala Ala Gly Gly Cys Ala Ala Gly Gly Gly 
                405                 410                 415     


Gly Ala Ala Thr Gly Cys Thr Ala Ala Cys Cys Thr Thr Gly Ala Gly 
            420                 425                 430         


Thr Ala Thr Ala Ala Ala Ala Cys Thr Gly Gly Ala Gly Cys Cys Thr 
        435                 440                 445             


Thr Cys Ala Gly Cys Ala Thr Gly Cys Cys Gly Gly Ala Ala Gly Thr 
    450                 455                 460                 


Gly Ala Ala Thr Gly Thr Gly Gly Ala Cys Thr Ala Thr Ala Ala Thr 
465                 470                 475                 480 


Gly Cys Cys Ala Gly Cys Thr Cys Ala Gly Ala Gly Ala Cys Cys Thr 
                485                 490                 495     


Thr Gly Cys Gly Gly Thr Gly Thr Gly Ala Gly Gly Cys Thr Cys Cys 
            500                 505                 510         


Cys Cys Gly Ala Thr Gly Gly Thr Thr Cys Cys Cys Cys Cys Ala Gly 
        515                 520                 525             


Cys Cys Cys Ala Cys Ala Gly Thr Gly Gly Thr Cys Thr Gly Gly Gly 
    530                 535                 540                 


Cys Ala Thr Cys Cys Cys Ala Ala Gly Thr Thr Gly Ala Cys Cys Ala 
545                 550                 555                 560 


Gly Gly Gly Ala Gly Cys Cys Ala Ala Cys Thr Thr Cys Thr Cys Gly 
                565                 570                 575     


Gly Ala Ala Gly Thr Cys Thr Cys Cys Ala Ala Thr Ala Cys Cys Ala 
            580                 585                 590         


Gly Cys Thr Thr Thr Gly Ala Gly Cys Thr Gly Ala Ala Cys Thr Cys 
        595                 600                 605             


Thr Gly Ala Gly Ala Ala Thr Gly Thr Gly Ala Cys Cys Ala Thr Gly 
    610                 615                 620                 


Ala Ala Gly Gly Thr Thr Gly Thr Gly Thr Cys Thr Gly Thr Gly Cys 
625                 630                 635                 640 


Thr Cys Thr Ala Cys Ala Ala Thr Gly Thr Thr Ala Cys Gly Ala Thr 
                645                 650                 655     


Cys Ala Ala Cys Ala Ala Cys Ala Cys Ala Thr Ala Cys Thr Cys Cys 
            660                 665                 670         


Thr Gly Thr Ala Thr Gly Ala Thr Thr Gly Ala Ala Ala Ala Thr Gly 
        675                 680                 685             


Ala Cys Ala Thr Thr Gly Cys Cys Ala Ala Ala Gly Cys Ala Ala Cys 
    690                 695                 700                 


Ala Gly Gly Gly Gly Ala Thr Ala Thr Cys Ala Ala Ala Gly Thr Gly 
705                 710                 715                 720 


Ala Cys Ala Gly Ala Ala Thr Cys Gly Gly Ala Gly Ala Thr Cys Ala 
                725                 730                 735     


Ala Ala Ala Gly Gly Cys Gly Gly Ala Gly Thr Gly Ala Gly Cys Cys 
            740                 745                 750         


Thr Ala Ala Gly Thr Cys Ala Thr Gly Thr Gly Ala Cys Ala Ala Gly 
        755                 760                 765             


Ala Cys Cys Cys Ala Thr Ala Cys Gly Thr Gly Cys Cys Cys Ala Cys 
    770                 775                 780                 


Cys Cys Thr Gly Thr Cys Cys Cys Gly Cys Thr Cys Cys Ala Gly Ala 
785                 790                 795                 800 


Ala Cys Thr Gly Cys Thr Gly Gly Gly Gly Gly Gly Ala Cys Cys Thr 
                805                 810                 815     


Ala Gly Cys Gly Thr Thr Thr Thr Cys Thr Thr Gly Thr Thr Cys Cys 
            820                 825                 830         


Cys Cys Cys Cys Ala Ala Ala Gly Cys Cys Cys Ala Ala Gly Gly Ala 
        835                 840                 845             


Cys Ala Cys Cys Cys Thr Cys Ala Thr Gly Ala Thr Cys Thr Cys Ala 
    850                 855                 860                 


Cys Gly Gly Ala Cys Thr Cys Cys Cys Gly Ala Ala Gly Thr Ala Ala 
865                 870                 875                 880 


Cys Ala Thr Gly Cys Gly Thr Ala Gly Thr Ala Gly Thr Cys Gly Ala 
                885                 890                 895     


Cys Gly Thr Gly Ala Gly Cys Cys Ala Cys Gly Ala Gly Gly Ala Thr 
            900                 905                 910         


Cys Cys Thr Gly Ala Ala Gly Thr Gly Ala Ala Gly Thr Thr Thr Ala 
        915                 920                 925             


Ala Thr Thr Gly Gly Thr Ala Cys Gly Thr Gly Gly Ala Cys Gly Gly 
    930                 935                 940                 


Ala Gly Thr Cys Gly Ala Gly Gly Thr Gly Cys Ala Thr Ala Ala Thr 
945                 950                 955                 960 


Gly Cys Cys Ala Ala Ala Ala Cys Thr Ala Ala Ala Cys Cys Thr Cys 
                965                 970                 975     


Gly Gly Gly Ala Gly Gly Ala Gly Cys Ala Gly Thr Ala Thr Ala Ala 
            980                 985                 990         


Cys Ala Gly Thr Ala Cys Cys Thr  Ala Cys Cys Gly Cys  Gly Thr Gly 
        995                 1000                 1005             


Gly Thr  Ala Thr Cys Cys Gly  Thr Cys Thr Thr Gly  Ala Cys Ala 
    1010                 1015                 1020             


Gly Thr  Gly Cys Thr Cys Cys  Ala Cys Cys Ala Gly  Gly Ala Cys 
    1025                 1030                 1035             


Thr Gly  Gly Cys Thr Gly Ala  Ala Thr Gly Gly Thr  Ala Ala Gly 
    1040                 1045                 1050             


Gly Ala  Gly Thr Ala Thr Ala  Ala Ala Thr Gly Cys  Ala Ala Gly 
    1055                 1060                 1065             


Gly Thr  Cys Ala Gly Cys Ala  Ala Cys Ala Ala Ala  Gly Cys Thr 
    1070                 1075                 1080             


Cys Thr  Thr Cys Cys Cys Gly  Cys Cys Cys Cys Ala  Ala Thr Thr 
    1085                 1090                 1095             


Gly Ala  Ala Ala Ala Gly Ala  Cys Thr Ala Thr Cys  Ala Gly Cys 
    1100                 1105                 1110             


Ala Ala  Gly Gly Cys Cys Ala  Ala Gly Gly Gly Ala  Cys Ala Ala 
    1115                 1120                 1125             


Cys Cys  Cys Cys Gly Cys Gly  Ala Gly Cys Cys Cys  Cys Ala Gly 
    1130                 1135                 1140             


Gly Thr  Thr Thr Ala Cys Ala  Cys Cys Cys Thr Thr  Cys Cys Ala 
    1145                 1150                 1155             


Cys Cys  Thr Thr Cys Ala Cys  Gly Ala Gly Ala Cys  Gly Ala Gly 
    1160                 1165                 1170             


Cys Thr  Gly Ala Cys Cys Ala  Ala Gly Ala Ala Cys  Cys Ala Gly 
    1175                 1180                 1185             


Gly Thr  Gly Thr Cys Thr Cys  Thr Gly Ala Cys Thr  Thr Gly Thr 
    1190                 1195                 1200             


Cys Thr  Gly Gly Thr Cys Ala  Ala Ala Gly Gly Thr  Thr Thr Cys 
    1205                 1210                 1215             


Thr Ala  Thr Cys Cys Thr Thr  Cys Cys Gly Ala Cys  Ala Thr Cys 
    1220                 1225                 1230             


Gly Cys  Ala Gly Thr Gly Gly  Ala Gly Thr Gly Gly  Gly Ala Gly 
    1235                 1240                 1245             


Thr Cys  Ala Ala Ala Cys Gly  Gly Gly Cys Ala Gly  Cys Cys Thr 
    1250                 1255                 1260             


Gly Ala  Gly Ala Ala Thr Ala  Ala Cys Thr Ala Cys  Ala Ala Gly 
    1265                 1270                 1275             


Ala Cys  Cys Ala Cys Ala Cys  Cys Cys Cys Cys Ala  Gly Thr Gly 
    1280                 1285                 1290             


Cys Thr  Thr Gly Ala Thr Ala  Gly Cys Gly Ala Thr  Gly Gly Gly 
    1295                 1300                 1305             


Ala Gly  Cys Thr Thr Thr Thr  Thr Cys Cys Thr Cys  Thr Ala Cys 
    1310                 1315                 1320             


Ala Gly  Thr Ala Ala Gly Cys  Thr Gly Ala Cys Thr  Gly Thr Gly 
    1325                 1330                 1335             


Gly Ala  Cys Ala Ala Ala Thr  Cys Cys Cys Gly Cys  Thr Gly Gly 
    1340                 1345                 1350             


Cys Ala  Gly Cys Ala Gly Gly  Gly Ala Ala Ala Cys  Gly Thr Thr 
    1355                 1360                 1365             


Thr Thr  Cys Thr Cys Thr Thr  Gly Thr Ala Gly Cys  Gly Thr Cys 
    1370                 1375                 1380             


Ala Thr  Gly Cys Ala Thr Gly  Ala Gly Gly Cys Cys  Cys Thr Cys 
    1385                 1390                 1395             


Cys Ala  Cys Ala Ala Cys Cys  Ala Thr Thr Ala Thr  Ala Cys Thr 
    1400                 1405                 1410             


Cys Ala  Gly Ala Ala Ala Ala  Gly Cys Cys Thr Gly  Ala Gly Thr 
    1415                 1420                 1425             


Cys Thr  Gly Ala Gly Thr Cys  Cys Cys Gly Gly Cys  Ala Ala Ala 
    1430                 1435                 1440             


<210>  106
<211>  1419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion nucleotide

<400>  106
atggaatgga gctgggtatt tctgtttttc ctgtcagtaa cgactggcgt ccattcaggc       60

ttcggcatca gtggacggca cagtatcaca gtgaccaccg tcgcctccgc tggcaatata      120

ggtgaggatg gcatccagtc ctgtaccttt gagccggaca tcaaactgtc tgacatagtg      180

atacaatggc tgaaggaggg ggtgctcggt ctggtacatg agtttaagga agggaaggat      240

gaactgtccg agcaggatga gatgttccgg gggaggaccg ctgtgttcgc cgatcaggta      300

atcgtcggaa atgcaagtct cagattgaaa aatgtgcaac tgactgatgc tggcacgtat      360

aaatgctaca ttatcacaag taagggcaaa ggaaatgcta accttgagta taaaacaggc      420

gcattctcaa tgcccgaggt caatgtcgac tataatgcca gcagtgaaac attgcgctgt      480

gaagctcccc gctggttccc ccagccaacc gtggtctggg cctctcaggt tgatcagggg      540

gctaactttt ccgaggtgag caacaccagc ttcgaactca actctgagaa tgtgaccatg      600

aaagttgtgt ctgtcctgta taatgtaaca atcaacaaca cttattcatg catgattgaa      660

aacgacatcg ccaaggcaac aggtgatatt aaggtaactg aatccgagat caaacggcgg      720

tctgagccta agtcatgtga caagacccat acgtgcccac cctgtcccgc tccagaactg      780

ctggggggac ctagcgtttt cttgttcccc ccaaagccca aggacaccct catgatctca      840

cggactcccg aagtaacatg cgtagtagtc gacgtgagcc acgaggatcc tgaagtgaag      900

tttaattggt acgtggacgg agtcgaggtg cataatgcca aaactaaacc tcgggaggag      960

cagtataaca gtacctaccg cgtggtatcc gtcttgacag tgctccacca ggactggctg     1020

aatggtaagg agtataaatg caaggtcagc aacaaagctc ttcccgcccc aattgaaaag     1080

actatcagca aggccaaggg acaaccccgc gagccccagg tttacaccct tccaccttca     1140

cgagacgagc tgaccaagaa ccaggtgtct ctgacttgtc tggtcaaagg tttctatcct     1200

tccgacatcg cagtggagtg ggagtcaaac gggcagcctg agaataacta caagaccaca     1260

cccccagtgc ttgatagcga tgggagcttt ttcctctaca gtaagctgac tgtggacaaa     1320

tcccgctggc agcagggaaa cgttttctct tgtagcgtca tgcatgaggc cctccacaac     1380

cattatactc agaaaagcct gagtctgagt cccggcaaa                            1419


<210>  107
<211>  1404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion nucleotide

<400>  107
atggaatgga gctgggtatt tctgtttttc ctgtcagtaa cgactggcgt ccattcaggc       60

ttcggcatca gtggacggca cagtatcaca gtgaccaccg tcgcctccgc tggcaatata      120

ggtgaggatg gcatccagtc ctgtaccttt gagccggaca tcaaactgtc tgacatagtg      180

atacaatggc tgaaggaggg ggtgctcggt ctggtacatg agtttaagga agggaaggat      240

gaactgtccg agcaggatga gatgttccgg gggaggaccg ctgtgttcgc cgatcaggta      300

atcgtcggaa atgcaagtct cagattgaaa aatgtgcaac tgactgatgc tggcacgtat      360

aaatgctaca ttatcacaag taagggcaaa ggaaatgcta accttgagta taaaacaggc      420

gcattctcaa tgcccgaggt caatgtcgac tataatgcca gcagtgaaac attgcgctgt      480

gaagctcccc gctggttccc ccagccaacc gtggtctggg cctctcaggt tgatcagggg      540

gctaactttt ccgaggtgag caacaccagc ttcgaactca actctgagaa tgtgaccatg      600

aaagttgtgt ctgtcctgta taatgtaaca atcaacaaca cttattcatg catgattgaa      660

aacgacatcg ccaaggcaac aggtgatatt aaggtaactg aatccgagat caaacggcgg      720

tctgacaaga cccatacgtg cccaccctgt cccgctccag aactgctggg gggacctagc      780

gttttcttgt tccccccaaa gcccaaggac accctcatga tctcacggac tcccgaagta      840

acatgcgtag tagtcgacgt gagccacgag gatcctgaag tgaagtttaa ttggtacgtg      900

gacggagtcg aggtgcataa tgccaaaact aaacctcggg aggagcagta taacagtacc      960

taccgcgtgg tatccgtctt gacagtgctc caccaggact ggctgaatgg taaggagtat     1020

aaatgcaagg tcagcaacaa agctcttccc gccccaattg aaaagactat cagcaaggcc     1080

aagggacaac cccgcgagcc ccaggtttac acccttccac cttcacgaga cgagctgacc     1140

aagaaccagg tgtctctgac ttgtctggtc aaaggtttct atccttccga catcgcagtg     1200

gagtgggagt caaacgggca gcctgagaat aactacaaga ccacaccccc agtgcttgat     1260

agcgatggga gctttttcct ctacagtaag ctgactgtgg acaaatcccg ctggcagcag     1320

ggaaacgttt tctcttgtag cgtcatgcat gaggccctcc acaaccatta tactcagaaa     1380

agcctgagtc tgagtcccgg caaa                                            1404


<210>  108
<211>  1392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion nucleotide

<400>  108
atggaatgga gctgggtatt tctgtttttc ctgtcagtaa cgactggcgt ccattcaggc       60

ttcggcatca gtggacggca cagtatcaca gtgaccaccg tcgcctccgc tggcaatata      120

ggtgaggatg gcatccagtc ctgtaccttt gagccggaca tcaaactgtc tgacatagtg      180

atacaatggc tgaaggaggg ggtgctcggt ctggtacatg agtttaagga agggaaggat      240

gaactgtccg agcaggatga gatgttccgg gggaggaccg ctgtgttcgc cgatcaggta      300

atcgtcggaa atgcaagtct cagattgaaa aatgtgcaac tgactgatgc tggcacgtat      360

aaatgctaca ttatcacaag taagggcaaa ggaaatgcta accttgagta taaaacaggc      420

gcattctcaa tgcccgaggt caatgtcgac tataatgcca gcagtgaaac attgcgctgt      480

gaagctcccc gctggttccc ccagccaacc gtggtctggg cctctcaggt tgatcagggg      540

gctaactttt ccgaggtgag caacaccagc ttcgaactca actctgagaa tgtgaccatg      600

aaagttgtgt ctgtcctgta taatgtaaca atcaacaaca cttattcatg catgattgaa      660

aacgacatcg ccaaggcaac aggtgatatt aaggtaactg aatccgagat cgacaagacc      720

catacgtgcc caccctgtcc cgctccagaa ctgctggggg gacctagcgt tttcttgttc      780

cccccaaagc ccaaggacac cctcatgatc tcacggactc ccgaagtaac atgcgtagta      840

gtcgacgtga gccacgagga tcctgaagtg aagtttaatt ggtacgtgga cggagtcgag      900

gtgcataatg ccaaaactaa acctcgggag gagcagtata acagtaccta ccgcgtggta      960

tccgtcttga cagtgctcca ccaggactgg ctgaatggta aggagtataa atgcaaggtc     1020

agcaacaaag ctcttcccgc cccaattgaa aagactatca gcaaggccaa gggacaaccc     1080

cgcgagcccc aggtttacac ccttccacct tcacgagacg agctgaccaa gaaccaggtg     1140

tctctgactt gtctggtcaa aggtttctat ccttccgaca tcgcagtgga gtgggagtca     1200

aacgggcagc ctgagaataa ctacaagacc acacccccag tgcttgatag cgatgggagc     1260

tttttcctct acagtaagct gactgtggac aaatcccgct ggcagcaggg aaacgttttc     1320

tcttgtagcg tcatgcatga ggccctccac aaccattata ctcagaaaag cctgagtctg     1380

agtcccggca aa                                                         1392


<210>  109
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion nucleotide

<400>  109
atggaatgga gctgggtatt tctgtttttc ctgtcagtaa cgactggcgt ccattcaggc       60

ttcggcatca gtggacggca cagtatcaca gtgaccaccg tcgcctccgc tggcaatata      120

ggtgaggatg gcatccagtc ctgtaccttt gagccggaca tcaaactgtc tgacatagtg      180

atacaatggc tgaaggaggg ggtgctcggt ctggtacatg agtttaagga agggaaggat      240

gaactgtccg agcaggatga gatgttccgg gggaggaccg ctgtgttcgc cgatcaggta      300

atcgtcggaa atgcaagtct cagattgaaa aatgtgcaac tgactgatgc tggcacgtat      360

aaatgctaca ttatcacaag taagggcaaa ggaaatgcta accttgagta taaaacaggc      420

gcattctcaa tgcccgaggt caatgtcgac tataatgcca gcagtgaaac attgcgctgt      480

gaagctcccc gctggttccc ccagccaacc gtggtctggg cctctcaggt tgatcagggg      540

gctaactttt ccgaggtgag caacaccagc ttcgaactca actctgagaa tgtgaccatg      600

aaagttgtgt ctgtcctgta taatgtaaca atcaacaaca cttattcatg catgattgaa      660

aacgacatcg ccaaggcaac aggtgatatt aaggtaactg aatccgagat caaacggcgg      720

tctcacctgc agctgctgaa ctccaaggac aagacccata cgtgcccacc ctgtcccgct      780

ccagaactgc tggggggacc tagcgttttc ttgttccccc caaagcccaa ggacaccctc      840

atgatctcac ggactcccga agtaacatgc gtagtagtcg acgtgagcca cgaggatcct      900

gaagtgaagt ttaattggta cgtggacgga gtcgaggtgc ataatgccaa aactaaacct      960

cgggaggagc agtataacag tacctaccgc gtggtatccg tcttgacagt gctccaccag     1020

gactggctga atggtaagga gtataaatgc aaggtcagca acaaagctct tcccgcccca     1080

attgaaaaga ctatcagcaa ggccaaggga caaccccgcg agccccaggt ttacaccctt     1140

ccaccttcac gagacgagct gaccaagaac caggtgtctc tgacttgtct ggtcaaaggt     1200

ttctatcctt ccgacatcgc agtggagtgg gagtcaaacg ggcagcctga gaataactac     1260

aagaccacac ccccagtgct tgatagcgat gggagctttt tcctctacag taagctgact     1320

gtggacaaat cccgctggca gcagggaaac gttttctctt gtagcgtcat gcatgaggcc     1380

ctccacaacc attatactca gaaaagcctg agtctgagtc ccggcaaa                  1428


<210>  110
<211>  1419
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion nucleotide

<400>  110
atggaatgga gctgggtatt tctgtttttc ctgtcagtaa cgactggcgt ccattcaggc       60

ttcggcatca gtggacggca cagtatcaca gtgaccaccg tcgcctccgc tggcaatata      120

ggtgaggatg gcatcctgtc ctgtaccttt gagccggaca tcaaactgtc tgacatagtg      180

atacaatggc tgaaggaggg ggtgctcggt ctggtacatg agtttaagga agggaaggat      240

gaactgtccg agcaggatga gatgttccgg gggaggaccg ctgtgttcgc cgatcaggta      300

atcgtcggaa atgcaagtct cagattgaaa aatgtgcaac tgactgatgc tggcacgtat      360

aaatgctaca ttatcacaag taagggcaaa ggaaatgcta accttgagta taaaacaggc      420

gcattctcaa tgcccgaggt caatgtcgac tataatgcca gcagtgaaac attgcgctgt      480

gaagctcccc gctggttccc ccagccaacc gtggtctggg cctctcaggt tgatcagggg      540

gctaactttt ccgaggtgag caacaccagc ttcgaactca actctgagaa tgtgaccatg      600

aaagttgtgt ctgtcctgta taatgtaaca atcaacaaca cttattcatg catgattgaa      660

aacgacatcg ccaaggcaac aggtgatatt aaggtaactg aatccgagat caaacggcgg      720

tctgagccta agtcatgtga caagacccat acgtgcccac cctgtcccgc tccagaactg      780

ctggggggac ctagcgtttt cttgttcccc ccaaagccca aggacaccct catgatctca      840

cggactcccg aagtaacatg cgtagtagtc gacgtgagcc acgaggatcc tgaagtgaag      900

tttaattggt acgtggacgg agtcgaggtg cataatgcca aaactaaacc tcgggaggag      960

cagtataaca gtacctaccg cgtggtatcc gtcttgacag tgctccacca ggactggctg     1020

aatggtaagg agtataaatg caaggtcagc aacaaagctc ttcccgcccc aattgaaaag     1080

actatcagca aggccaaggg acaaccccgc gagccccagg tttacaccct tccaccttca     1140

cgagacgagc tgaccaagaa ccaggtgtct ctgacttgtc tggtcaaagg tttctatcct     1200

tccgacatcg cagtggagtg ggagtcaaac gggcagcctg agaataacta caagaccaca     1260

cccccagtgc ttgatagcga tgggagcttt ttcctctaca gtaagctgac tgtggacaaa     1320

tcccgctggc agcagggaaa cgttttctct tgtagcgtca tgcatgaggc cctccacaac     1380

cattatactc agaaaagcct gagtctgagt cccggcaaa                            1419


<210>  111
<211>  1404
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion nucleotide

<400>  111
atggaatgga gctgggtatt tctgtttttc ctgtcagtaa cgactggcgt ccattcaggc       60

ttcggcatca gtggacggca cagtatcaca gtgaccaccg tcgcctccgc tggcaatata      120

ggtgaggatg gcatcctgtc ctgtaccttt gagccggaca tcaaactgtc tgacatagtg      180

atacaatggc tgaaggaggg ggtgctcggt ctggtacatg agtttaagga agggaaggat      240

gaactgtccg agcaggatga gatgttccgg gggaggaccg ctgtgttcgc cgatcaggta      300

atcgtcggaa atgcaagtct cagattgaaa aatgtgcaac tgactgatgc tggcacgtat      360

aaatgctaca ttatcacaag taagggcaaa ggaaatgcta accttgagta taaaacaggc      420

gcattctcaa tgcccgaggt caatgtcgac tataatgcca gcagtgaaac attgcgctgt      480

gaagctcccc gctggttccc ccagccaacc gtggtctggg cctctcaggt tgatcagggg      540

gctaactttt ccgaggtgag caacaccagc ttcgaactca actctgagaa tgtgaccatg      600

aaagttgtgt ctgtcctgta taatgtaaca atcaacaaca cttattcatg catgattgaa      660

aacgacatcg ccaaggcaac aggtgatatt aaggtaactg aatccgagat caaacggcgg      720

tctgacaaga cccatacgtg cccaccctgt cccgctccag aactgctggg gggacctagc      780

gttttcttgt tccccccaaa gcccaaggac accctcatga tctcacggac tcccgaagta      840

acatgcgtag tagtcgacgt gagccacgag gatcctgaag tgaagtttaa ttggtacgtg      900

gacggagtcg aggtgcataa tgccaaaact aaacctcggg aggagcagta taacagtacc      960

taccgcgtgg tatccgtctt gacagtgctc caccaggact ggctgaatgg taaggagtat     1020

aaatgcaagg tcagcaacaa agctcttccc gccccaattg aaaagactat cagcaaggcc     1080

aagggacaac cccgcgagcc ccaggtttac acccttccac cttcacgaga cgagctgacc     1140

aagaaccagg tgtctctgac ttgtctggtc aaaggtttct atccttccga catcgcagtg     1200

gagtgggagt caaacgggca gcctgagaat aactacaaga ccacaccccc agtgcttgat     1260

agcgatggga gctttttcct ctacagtaag ctgactgtgg acaaatcccg ctggcagcag     1320

ggaaacgttt tctcttgtag cgtcatgcat gaggccctcc acaaccatta tactcagaaa     1380

agcctgagtc tgagtcccgg caaa                                            1404


<210>  112
<211>  1392
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion nucleotide

<400>  112
atggaatgga gctgggtatt tctgtttttc ctgtcagtaa cgactggcgt ccattcaggc       60

ttcggcatca gtggacggca cagtatcaca gtgaccaccg tcgcctccgc tggcaatata      120

ggtgaggatg gcatcctgtc ctgtaccttt gagccggaca tcaaactgtc tgacatagtg      180

atacaatggc tgaaggaggg ggtgctcggt ctggtacatg agtttaagga agggaaggat      240

gaactgtccg agcaggatga gatgttccgg gggaggaccg ctgtgttcgc cgatcaggta      300

atcgtcggaa atgcaagtct cagattgaaa aatgtgcaac tgactgatgc tggcacgtat      360

aaatgctaca ttatcacaag taagggcaaa ggaaatgcta accttgagta taaaacaggc      420

gcattctcaa tgcccgaggt caatgtcgac tataatgcca gcagtgaaac attgcgctgt      480

gaagctcccc gctggttccc ccagccaacc gtggtctggg cctctcaggt tgatcagggg      540

gctaactttt ccgaggtgag caacaccagc ttcgaactca actctgagaa tgtgaccatg      600

aaagttgtgt ctgtcctgta taatgtaaca atcaacaaca cttattcatg catgattgaa      660

aacgacatcg ccaaggcaac aggtgatatt aaggtaactg aatccgagat cgacaagacc      720

catacgtgcc caccctgtcc cgctccagaa ctgctggggg gacctagcgt tttcttgttc      780

cccccaaagc ccaaggacac cctcatgatc tcacggactc ccgaagtaac atgcgtagta      840

gtcgacgtga gccacgagga tcctgaagtg aagtttaatt ggtacgtgga cggagtcgag      900

gtgcataatg ccaaaactaa acctcgggag gagcagtata acagtaccta ccgcgtggta      960

tccgtcttga cagtgctcca ccaggactgg ctgaatggta aggagtataa atgcaaggtc     1020

agcaacaaag ctcttcccgc cccaattgaa aagactatca gcaaggccaa gggacaaccc     1080

cgcgagcccc aggtttacac ccttccacct tcacgagacg agctgaccaa gaaccaggtg     1140

tctctgactt gtctggtcaa aggtttctat ccttccgaca tcgcagtgga gtgggagtca     1200

aacgggcagc ctgagaataa ctacaagacc acacccccag tgcttgatag cgatgggagc     1260

tttttcctct acagtaagct gactgtggac aaatcccgct ggcagcaggg aaacgttttc     1320

tcttgtagcg tcatgcatga ggccctccac aaccattata ctcagaaaag cctgagtctg     1380

agtcccggca aa                                                         1392


<210>  113
<211>  1428
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion nucleotide

<400>  113
atggaatgga gctgggtatt tctgtttttc ctgtcagtaa cgactggcgt ccattcaggc       60

ttcggcatca gtggacggca cagtatcaca gtgaccaccg tcgcctccgc tggcaatata      120

ggtgaggatg gcatcctgtc ctgtaccttt gagccggaca tcaaactgtc tgacatagtg      180

atacaatggc tgaaggaggg ggtgctcggt ctggtacatg agtttaagga agggaaggat      240

gaactgtccg agcaggatga gatgttccgg gggaggaccg ctgtgttcgc cgatcaggta      300

atcgtcggaa atgcaagtct cagattgaaa aatgtgcaac tgactgatgc tggcacgtat      360

aaatgctaca ttatcacaag taagggcaaa ggaaatgcta accttgagta taaaacaggc      420

gcattctcaa tgcccgaggt caatgtcgac tataatgcca gcagtgaaac attgcgctgt      480

gaagctcccc gctggttccc ccagccaacc gtggtctggg cctctcaggt tgatcagggg      540

gctaactttt ccgaggtgag caacaccagc ttcgaactca actctgagaa tgtgaccatg      600

aaagttgtgt ctgtcctgta taatgtaaca atcaacaaca cttattcatg catgattgaa      660

aacgacatcg ccaaggcaac aggtgatatt aaggtaactg aatccgagat caaacggcgg      720

tctcacctgc agctgctgaa ctccaaggac aagacccata cgtgcccacc ctgtcccgct      780

ccagaactgc tggggggacc tagcgttttc ttgttccccc caaagcccaa ggacaccctc      840

atgatctcac ggactcccga agtaacatgc gtagtagtcg acgtgagcca cgaggatcct      900

gaagtgaagt ttaattggta cgtggacgga gtcgaggtgc ataatgccaa aactaaacct      960

cgggaggagc agtataacag tacctaccgc gtggtatccg tcttgacagt gctccaccag     1020

gactggctga atggtaagga gtataaatgc aaggtcagca acaaagctct tcccgcccca     1080

attgaaaaga ctatcagcaa ggccaaggga caaccccgcg agccccaggt ttacaccctt     1140

ccaccttcac gagacgagct gaccaagaac caggtgtctc tgacttgtct ggtcaaaggt     1200

ttctatcctt ccgacatcgc agtggagtgg gagtcaaacg ggcagcctga gaataactac     1260

aagaccacac ccccagtgct tgatagcgat gggagctttt tcctctacag taagctgact     1320

gtggacaaat cccgctggca gcagggaaac gttttctctt gtagcgtcat gcatgaggcc     1380

ctccacaacc attatactca gaaaagcctg agtctgagtc ccggcaaa                  1428


<210>  114
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetis fusion protein

<400>  114

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Gln Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser Glu Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  115
<211>  536
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  115

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Gln Ser Cys Thr Phe Glu Pro Met Ala Ser Leu 
    50                  55                  60                  


Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile Ile Ile Leu Ala 
65                  70                  75                  80  


Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser Gly Arg His Ser 
                85                  90                  95      


Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly 
            100                 105                 110         


Ile Gln Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val 
        115                 120                 125             


Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys 
    130                 135                 140                 


Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg 
145                 150                 155                 160 


Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg 
                165                 170                 175     


Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile 
            180                 185                 190         


Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly 
        195                 200                 205             


Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu 
    210                 215                 220                 


Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val 
225                 230                 235                 240 


Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn 
                245                 250                 255     


Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser 
            260                 265                 270         


Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu 
        275                 280                 285             


Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu 
    290                 295                 300                 


Ile Lys Arg Arg Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
305                 310                 315                 320 


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
                325                 330                 335     


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
            340                 345                 350         


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
        355                 360                 365             


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
    370                 375                 380                 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
385                 390                 395                 400 


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
                405                 410                 415     


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
            420                 425                 430         


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
        435                 440                 445             


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
    450                 455                 460                 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
465                 470                 475                 480 


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
                485                 490                 495     


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
            500                 505                 510         


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
        515                 520                 525             


Ser Leu Ser Leu Ser Pro Gly Lys 
    530                 535     


<210>  116
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  116

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Gln Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         


<210>  117
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  117

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Gln Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Pro Gly Lys 
                


<210>  118
<211>  481
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  118

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser Glu Pro Lys Ser Cys Asp Lys 
                245                 250                 255     


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
            260                 265                 270         


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
        275                 280                 285             


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
    290                 295                 300                 


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
305                 310                 315                 320 


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
                325                 330                 335     


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
            340                 345                 350         


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
        355                 360                 365             


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
    370                 375                 380                 


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
385                 390                 395                 400 


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
                405                 410                 415     


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
            420                 425                 430         


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
        435                 440                 445             


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
    450                 455                 460                 


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
465                 470                 475                 480 


Lys 
    


<210>  119
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  119

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475     


<210>  120
<211>  472
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  120

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala 
                245                 250                 255     


Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro 
            260                 265                 270         


Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val 
        275                 280                 285             


Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val 
    290                 295                 300                 


Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln 
305                 310                 315                 320 


Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln 
                325                 330                 335     


Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala 
            340                 345                 350         


Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro 
        355                 360                 365             


Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr 
    370                 375                 380                 


Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser 
385                 390                 395                 400 


Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr 
                405                 410                 415     


Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr 
            420                 425                 430         


Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe 
        435                 440                 445             


Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys 
    450                 455                 460                 


Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470         


<210>  121
<211>  484
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  121

Met Ala Ser Leu Gly Gln Ile Leu Phe Trp Ser Ile Ile Ser Ile Ile 
1               5                   10                  15      


Ile Ile Leu Ala Gly Ala Ile Ala Leu Ile Ile Gly Phe Gly Ile Ser 
            20                  25                  30          


Gly Arg His Ser Ile Thr Val Thr Thr Val Ala Ser Ala Gly Asn Ile 
        35                  40                  45              


Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu Pro Asp Ile Lys Leu 
    50                  55                  60                  


Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly Val Leu Gly Leu Val 
65                  70                  75                  80  


His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser Glu Gln Asp Glu Met 
                85                  90                  95      


Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln Val Ile Val Gly Asn 
            100                 105                 110         


Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr Asp Ala Gly Thr Tyr 
        115                 120                 125             


Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly Asn Ala Asn Leu Glu 
    130                 135                 140                 


Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val Asn Val Asp Tyr Asn 
145                 150                 155                 160 


Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro Arg Trp Phe Pro Gln 
                165                 170                 175     


Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln Gly Ala Asn Phe Ser 
            180                 185                 190         


Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser Glu Asn Val Thr Met 
        195                 200                 205             


Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile Asn Asn Thr Tyr Ser 
    210                 215                 220                 


Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr Gly Asp Ile Lys Val 
225                 230                 235                 240 


Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu Gln Leu Leu Asn Ser 
                245                 250                 255     


Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
            260                 265                 270         


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
        275                 280                 285             


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
    290                 295                 300                 


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
305                 310                 315                 320 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
                325                 330                 335     


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
            340                 345                 350         


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
        355                 360                 365             


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
    370                 375                 380                 


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
385                 390                 395                 400 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
                405                 410                 415     


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
            420                 425                 430         


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
        435                 440                 445             


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
    450                 455                 460                 


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
465                 470                 475                 480 


Ser Pro Gly Lys 
                


<210>  122
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  122

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Gln Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  123
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  123

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Gln Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  124
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  124

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Gln Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


<210>  125
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  125

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Gln Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser His Leu Gln Leu Leu Asn Ser Lys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475     


<210>  126
<211>  473
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  126

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser Glu Pro Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
                245                 250                 255     


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
            260                 265                 270         


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
        275                 280                 285             


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
    290                 295                 300                 


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
305                 310                 315                 320 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
                325                 330                 335     


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
            340                 345                 350         


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
        355                 360                 365             


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
    370                 375                 380                 


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
385                 390                 395                 400 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
                405                 410                 415     


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
            420                 425                 430         


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
        435                 440                 445             


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
    450                 455                 460                 


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470             


<210>  127
<211>  468
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  127

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Pro Gly Lys 
465             


<210>  128
<211>  464
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  128

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Asp Lys Thr 
225                 230                 235                 240 


His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser 
                245                 250                 255     


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
            260                 265                 270         


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
        275                 280                 285             


Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
    290                 295                 300                 


Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val 
305                 310                 315                 320 


Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
                325                 330                 335     


Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr 
            340                 345                 350         


Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
        355                 360                 365             


Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys 
    370                 375                 380                 


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
385                 390                 395                 400 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp 
                405                 410                 415     


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
            420                 425                 430         


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
        435                 440                 445             


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455                 460                 


<210>  129
<211>  476
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  129

Met Glu Trp Ser Trp Val Phe Leu Phe Phe Leu Ser Val Thr Thr Gly 
1               5                   10                  15      


Val His Ser Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr 
            20                  25                  30          


Thr Val Ala Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys 
        35                  40                  45              


Thr Phe Glu Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu 
    50                  55                  60                  


Lys Glu Gly Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp 
65                  70                  75                  80  


Glu Leu Ser Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe 
                85                  90                  95      


Ala Asp Gln Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val 
            100                 105                 110         


Gln Leu Thr Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys 
        115                 120                 125             


Gly Lys Gly Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met 
    130                 135                 140                 


Pro Glu Val Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys 
145                 150                 155                 160 


Glu Ala Pro Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln 
                165                 170                 175     


Val Asp Gln Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu 
            180                 185                 190         


Leu Asn Ser Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn 
        195                 200                 205             


Val Thr Ile Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala 
    210                 215                 220                 


Lys Ala Thr Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg 
225                 230                 235                 240 


Ser His Leu Gln Leu Leu Asn Ser Lys Asp Lys Thr His Thr Cys Pro 
                245                 250                 255     


Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe 
            260                 265                 270         


Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val 
        275                 280                 285             


Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe 
    290                 295                 300                 


Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro 
305                 310                 315                 320 


Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr 
                325                 330                 335     


Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val 
            340                 345                 350         


Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala 
        355                 360                 365             


Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg 
    370                 375                 380                 


Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly 
385                 390                 395                 400 


Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro 
                405                 410                 415     


Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser 
            420                 425                 430         


Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln 
        435                 440                 445             


Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His 
    450                 455                 460                 


Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
465                 470                 475     


<210>  130
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  130

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Gln Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  131
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  131

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Gln Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  132
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  132

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Gln Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  133
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  133

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Gln Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu 
    210                 215                 220                 


Gln Leu Leu Asn Ser Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  134
<211>  454
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  134

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser Glu Pro 
    210                 215                 220                 


Lys Ser Cys Asp Lys Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu 
225                 230                 235                 240 


Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp 
                245                 250                 255     


Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp 
            260                 265                 270         


Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly 
        275                 280                 285             


Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn 
    290                 295                 300                 


Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp 
305                 310                 315                 320 


Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro 
                325                 330                 335     


Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu 
            340                 345                 350         


Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn 
        355                 360                 365             


Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile 
    370                 375                 380                 


Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr 
385                 390                 395                 400 


Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys 
                405                 410                 415     


Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys 
            420                 425                 430         


Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu 
        435                 440                 445             


Ser Leu Ser Pro Gly Lys 
    450                 


<210>  135
<211>  449
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  135

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser Asp Lys 
    210                 215                 220                 


Thr His Thr Cys Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro 
225                 230                 235                 240 


Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser 
                245                 250                 255     


Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp 
            260                 265                 270         


Pro Glu Val Lys Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn 
        275                 280                 285             


Ala Lys Thr Lys Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val 
    290                 295                 300                 


Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu 
305                 310                 315                 320 


Tyr Lys Cys Lys Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys 
                325                 330                 335     


Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr 
            340                 345                 350         


Leu Pro Pro Ser Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr 
        355                 360                 365             


Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu 
    370                 375                 380                 


Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu 
385                 390                 395                 400 


Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys 
                405                 410                 415     


Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu 
            420                 425                 430         


Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly 
        435                 440                 445             


Lys 
    


<210>  136
<211>  445
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  136

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Asp Lys Thr His Thr Cys 
    210                 215                 220                 


Pro Pro Cys Pro Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu 
225                 230                 235                 240 


Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu 
                245                 250                 255     


Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys 
            260                 265                 270         


Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys 
        275                 280                 285             


Pro Arg Glu Glu Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu 
    290                 295                 300                 


Thr Val Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys 
305                 310                 315                 320 


Val Ser Asn Lys Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys 
                325                 330                 335     


Ala Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser 
            340                 345                 350         


Arg Asp Glu Leu Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys 
        355                 360                 365             


Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln 
    370                 375                 380                 


Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly 
385                 390                 395                 400 


Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln 
                405                 410                 415     


Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn 
            420                 425                 430         


His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445 


<210>  137
<211>  457
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic fusion protein

<400>  137

Gly Phe Gly Ile Ser Gly Arg His Ser Ile Thr Val Thr Thr Val Ala 
1               5                   10                  15      


Ser Ala Gly Asn Ile Gly Glu Asp Gly Ile Leu Ser Cys Thr Phe Glu 
            20                  25                  30          


Pro Asp Ile Lys Leu Ser Asp Ile Val Ile Gln Trp Leu Lys Glu Gly 
        35                  40                  45              


Val Leu Gly Leu Val His Glu Phe Lys Glu Gly Lys Asp Glu Leu Ser 
    50                  55                  60                  


Glu Gln Asp Glu Met Phe Arg Gly Arg Thr Ala Val Phe Ala Asp Gln 
65                  70                  75                  80  


Val Ile Val Gly Asn Ala Ser Leu Arg Leu Lys Asn Val Gln Leu Thr 
                85                  90                  95      


Asp Ala Gly Thr Tyr Lys Cys Tyr Ile Ile Thr Ser Lys Gly Lys Gly 
            100                 105                 110         


Asn Ala Asn Leu Glu Tyr Lys Thr Gly Ala Phe Ser Met Pro Glu Val 
        115                 120                 125             


Asn Val Asp Tyr Asn Ala Ser Ser Glu Thr Leu Arg Cys Glu Ala Pro 
    130                 135                 140                 


Arg Trp Phe Pro Gln Pro Thr Val Val Trp Ala Ser Gln Val Asp Gln 
145                 150                 155                 160 


Gly Ala Asn Phe Ser Glu Val Ser Asn Thr Ser Phe Glu Leu Asn Ser 
                165                 170                 175     


Glu Asn Val Thr Met Lys Val Val Ser Val Leu Tyr Asn Val Thr Ile 
            180                 185                 190         


Asn Asn Thr Tyr Ser Cys Met Ile Glu Asn Asp Ile Ala Lys Ala Thr 
        195                 200                 205             


Gly Asp Ile Lys Val Thr Glu Ser Glu Ile Lys Arg Arg Ser His Leu 
    210                 215                 220                 


Gln Leu Leu Asn Ser Lys Asp Lys Thr His Thr Cys Pro Pro Cys Pro 
225                 230                 235                 240 


Ala Pro Glu Leu Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys 
                245                 250                 255     


Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val 
            260                 265                 270         


Val Val Asp Val Ser His Glu Asp Pro Glu Val Lys Phe Asn Trp Tyr 
        275                 280                 285             


Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu 
    290                 295                 300                 


Gln Tyr Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His 
305                 310                 315                 320 


Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys 
                325                 330                 335     


Ala Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln 
            340                 345                 350         


Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Asp Glu Leu 
        355                 360                 365             


Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro 
    370                 375                 380                 


Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn 
385                 390                 395                 400 


Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu 
                405                 410                 415     


Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly Asn Val 
            420                 425                 430         


Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln 
        435                 440                 445             


Lys Ser Leu Ser Leu Ser Pro Gly Lys 
    450                 455         


<210>  138
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  OVA323-339 Peptide

<400>  138

Ile Ser Gln Ala Val His Ala Ala His Ala Glu Ile Asn Glu Ala Gly 
1               5                   10                  15      


Arg 
    


<210>  139
<211>  13
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLP130-151 Peptide

<400>  139

His Ser Leu Gly Lys Trp Leu Gly His Pro Asp Lys Phe 
1               5                   10              


<210>  140
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  PLP130-151 Peptide

<400>  140

Asn Thr Trp Thr Thr Cys Gln Ser Ile Ala Phe Pro Ser Lys 
1               5                   10                  


<210>  141
<211>  21
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  MOG35-55 Peptide

<400>  141

Met Glu Val Gly Trp Tyr Arg Ser Pro Phe Ser Arg Val Val His Leu 
1               5                   10                  15      


Tyr Arg Asn Gly Lys 
            20      


