                               SEQUENCE LISTING	

<110> IMMUNOMEDICS, INC.
      IBC PHARMACEUTICALS, INC.
 
<120> COMPOSITIONS AND METHODS OF USE OF IMMUNOTOXINS COMPRISING 
      RANPIRNASE (RAP) SHOW POTENT CYTOTOXIC ACTIVITY

<130> IMM321WO1

<140> PCT/US10/47132
<141> 2010-08-30

<150> 61/323,960
<151> 2010-04-14

<150> 12/754,740
<151> 2010-04-06

<150> 12/754,140
<151> 2010-04-05

<150> 12/752,649
<151> 2010-04-01

<150> 12/731,781
<151> 2010-03-25

<150> 61/316,996
<151> 2010-03-24

<150> 12/644,146
<151> 2009-12-22

<150> 61/266,305
<151> 2009-12-03

<150> 61/238,473
<151> 2009-08-31

<160> 98    

<170> PatentIn version 3.5

<210> 1
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 1
Asn Tyr Gly Met Asn 
1               5   


<210> 2
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 2
Trp Ile Asn Thr Tyr Thr Gly Glu Pro Thr Tyr Thr Asp Asp Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 3
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 3
Gly Gly Phe Gly Ser Ser Tyr Trp Tyr Phe Asp Val 
1               5                   10          


<210> 4
<211> 11
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 4
Lys Ala Ser Gln Asp Val Ser Ile Ala Val Ala 
1               5                   10      


<210> 5
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 5
Ser Ala Ser Tyr Arg Tyr Thr 
1               5           


<210> 6
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 6
Gln Gln His Tyr Ile Thr Pro Leu Thr 
1               5                   


<210> 7
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 7
Arg Ala Ser Ser Ser Val Ser Tyr Ile His 
1               5                   10  


<210> 8
<211> 7
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 8
Ala Thr Ser Asn Leu Ala Ser 
1               5           


<210> 9
<211> 9
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 9
Gln Gln Trp Thr Ser Asn Pro Pro Thr 
1               5                   


<210> 10
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 10
Ser Tyr Asn Met His 
1               5   


<210> 11
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 11
Ala Ile Tyr Pro Gly Asn Gly Asp Thr Ser Tyr Asn Gln Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210> 12
<211> 13
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 12
Val Val Tyr Tyr Ser Asn Ser Tyr Trp Tyr Phe Asp Val 
1               5                   10              


<210> 13
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 13
Ser His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ala 
            20                  25                  30          


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  


<210> 14
<211> 45
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 14
Cys Gly His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly 
1               5                   10                  15      


Tyr Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe 
            20                  25                  30          


Ala Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala 
        35                  40                  45  


<210> 15
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 15
Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile Gln Gln 
1               5                   10                  15      


Ala 
    


<210> 16
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 16
Cys Gly Gln Ile Glu Tyr Leu Ala Lys Gln Ile Val Asp Asn Ala Ile 
1               5                   10                  15      


Gln Gln Ala Gly Cys 
            20      


<210> 17
<211> 50
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 17
Ser Leu Arg Glu Cys Glu Leu Tyr Val Gln Lys His Asn Ile Gln Ala 
1               5                   10                  15      


Leu Leu Lys Asp Ser Ile Val Gln Leu Cys Thr Ala Arg Pro Glu Arg 
            20                  25                  30          


Pro Met Ala Phe Leu Arg Glu Tyr Phe Glu Arg Leu Glu Lys Glu Glu 
        35                  40                  45              


Ala Lys 
    50  


<210> 18
<211> 55
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 18
Met Ser Cys Gly Gly Ser Leu Arg Glu Cys Glu Leu Tyr Val Gln Lys 
1               5                   10                  15      


His Asn Ile Gln Ala Leu Leu Lys Asp Ser Ile Val Gln Leu Cys Thr 
            20                  25                  30          


Ala Arg Pro Glu Arg Pro Met Ala Phe Leu Arg Glu Tyr Phe Glu Arg 
        35                  40                  45              


Leu Glu Lys Glu Glu Ala Lys 
    50                  55  


<210> 19
<211> 23
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 19
Cys Gly Phe Glu Glu Leu Ala Trp Lys Ile Ala Lys Met Ile Trp Ser 
1               5                   10                  15      


Asp Val Phe Gln Gln Gly Cys 
            20              


<210> 20
<211> 381
<212> PRT
<213> Homo sapiens

<400> 20
Met Ala Ser Pro Pro Ala Cys Pro Ser Glu Glu Asp Glu Ser Leu Lys 
1               5                   10                  15      


Gly Cys Glu Leu Tyr Val Gln Leu His Gly Ile Gln Gln Val Leu Lys 
            20                  25                  30          


Asp Cys Ile Val His Leu Cys Ile Ser Lys Pro Glu Arg Pro Met Lys 
        35                  40                  45              


Phe Leu Arg Glu His Phe Glu Lys Leu Glu Lys Glu Glu Asn Arg Gln 
    50                  55                  60                  


Ile Leu Ala Arg Gln Lys Ser Asn Ser Gln Ser Asp Ser His Asp Glu 
65                  70                  75                  80  


Glu Val Ser Pro Thr Pro Pro Asn Pro Val Val Lys Ala Arg Arg Arg 
                85                  90                  95      


Arg Gly Gly Val Ser Ala Glu Val Tyr Thr Glu Glu Asp Ala Val Ser 
            100                 105                 110         


Tyr Val Arg Lys Val Ile Pro Lys Asp Tyr Lys Thr Met Thr Ala Leu 
        115                 120                 125             


Ala Lys Ala Ile Ser Lys Asn Val Leu Phe Ala His Leu Asp Asp Asn 
    130                 135                 140                 


Glu Arg Ser Asp Ile Phe Asp Ala Met Phe Pro Val Thr His Ile Ala 
145                 150                 155                 160 


Gly Glu Thr Val Ile Gln Gln Gly Asn Glu Gly Asp Asn Phe Tyr Val 
                165                 170                 175     


Val Asp Gln Gly Glu Val Asp Val Tyr Val Asn Gly Glu Trp Val Thr 
            180                 185                 190         


Asn Ile Ser Glu Gly Gly Ser Phe Gly Glu Leu Ala Leu Ile Tyr Gly 
        195                 200                 205             


Thr Pro Arg Ala Ala Thr Val Lys Ala Lys Thr Asp Leu Lys Leu Trp 
    210                 215                 220                 


Gly Ile Asp Arg Asp Ser Tyr Arg Arg Ile Leu Met Gly Ser Thr Leu 
225                 230                 235                 240 


Arg Lys Arg Lys Met Tyr Glu Glu Phe Leu Ser Lys Val Ser Ile Leu 
                245                 250                 255     


Glu Ser Leu Glu Lys Trp Glu Arg Leu Thr Val Ala Asp Ala Leu Glu 
            260                 265                 270         


Pro Val Gln Phe Glu Asp Gly Glu Lys Ile Val Val Gln Gly Glu Pro 
        275                 280                 285             


Gly Asp Asp Phe Tyr Ile Ile Thr Glu Gly Thr Ala Ser Val Leu Gln 
    290                 295                 300                 


Arg Arg Ser Pro Asn Glu Glu Tyr Val Glu Val Gly Arg Leu Gly Pro 
305                 310                 315                 320 


Ser Asp Tyr Phe Gly Glu Ile Ala Leu Leu Leu Asn Arg Pro Arg Ala 
                325                 330                 335     


Ala Thr Val Val Ala Arg Gly Pro Leu Lys Cys Val Lys Leu Asp Arg 
            340                 345                 350         


Pro Arg Phe Glu Arg Val Leu Gly Pro Cys Ser Glu Ile Leu Lys Arg 
        355                 360                 365             


Asn Ile Gln Arg Tyr Asn Ser Phe Ile Ser Leu Thr Val 
    370                 375                 380     


<210> 21
<211> 418
<212> PRT
<213> Homo sapiens

<400> 21
Met Ser Ile Glu Ile Pro Ala Gly Leu Thr Glu Leu Leu Gln Gly Phe 
1               5                   10                  15      


Thr Val Glu Val Leu Arg His Gln Pro Ala Asp Leu Leu Glu Phe Ala 
            20                  25                  30          


Leu Gln His Phe Thr Arg Leu Gln Gln Glu Asn Glu Arg Lys Gly Thr 
        35                  40                  45              


Ala Arg Phe Gly His Glu Gly Arg Thr Trp Gly Asp Leu Gly Ala Ala 
    50                  55                  60                  


Ala Gly Gly Gly Thr Pro Ser Lys Gly Val Asn Phe Ala Glu Glu Pro 
65                  70                  75                  80  


Met Gln Ser Asp Ser Glu Asp Gly Glu Glu Glu Glu Ala Ala Pro Ala 
                85                  90                  95      


Asp Ala Gly Ala Phe Asn Ala Pro Val Ile Asn Arg Phe Thr Arg Arg 
            100                 105                 110         


Ala Ser Val Cys Ala Glu Ala Tyr Asn Pro Asp Glu Glu Glu Asp Asp 
        115                 120                 125             


Ala Glu Ser Arg Ile Ile His Pro Lys Thr Asp Asp Gln Arg Asn Arg 
    130                 135                 140                 


Leu Gln Glu Ala Cys Lys Asp Ile Leu Leu Phe Lys Asn Leu Asp Pro 
145                 150                 155                 160 


Glu Gln Met Ser Gln Val Leu Asp Ala Met Phe Glu Lys Leu Val Lys 
                165                 170                 175     


Asp Gly Glu His Val Ile Asp Gln Gly Asp Asp Gly Asp Asn Phe Tyr 
            180                 185                 190         


Val Ile Asp Arg Gly Thr Phe Asp Ile Tyr Val Lys Cys Asp Gly Val 
        195                 200                 205             


Gly Arg Cys Val Gly Asn Tyr Asp Asn Arg Gly Ser Phe Gly Glu Leu 
    210                 215                 220                 


Ala Leu Met Tyr Asn Thr Pro Arg Ala Ala Thr Ile Thr Ala Thr Ser 
225                 230                 235                 240 


Pro Gly Ala Leu Trp Gly Leu Asp Arg Val Thr Phe Arg Arg Ile Ile 
                245                 250                 255     


Val Lys Asn Asn Ala Lys Lys Arg Lys Met Tyr Glu Ser Phe Ile Glu 
            260                 265                 270         


Ser Leu Pro Phe Leu Lys Ser Leu Glu Phe Ser Glu Arg Leu Lys Val 
        275                 280                 285             


Val Asp Val Ile Gly Thr Lys Val Tyr Asn Asp Gly Glu Gln Ile Ile 
    290                 295                 300                 


Ala Gln Gly Asp Ser Ala Asp Ser Phe Phe Ile Val Glu Ser Gly Glu 
305                 310                 315                 320 


Val Lys Ile Thr Met Lys Arg Lys Gly Lys Ser Glu Val Glu Glu Asn 
                325                 330                 335     


Gly Ala Val Glu Ile Ala Arg Cys Ser Arg Gly Gln Tyr Phe Gly Glu 
            340                 345                 350         


Leu Ala Leu Val Thr Asn Lys Pro Arg Ala Ala Ser Ala His Ala Ile 
        355                 360                 365             


Gly Thr Val Lys Cys Leu Ala Met Asp Val Gln Ala Phe Glu Arg Leu 
    370                 375                 380                 


Leu Gly Pro Cys Met Glu Ile Met Lys Arg Asn Ile Ala Thr Tyr Glu 
385                 390                 395                 400 


Glu Gln Leu Val Ala Leu Phe Gly Thr Asn Met Asp Ile Val Glu Pro 
                405                 410                 415     


Thr Ala 
        


<210> 22
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(2)
<223> Any conservative amino acid substitution

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any conservative amino acid substitution

<220>
<221> MOD_RES
<222> (6)..(8)
<223> Any conservative amino acid substitution

<220>
<221> MOD_RES
<222> (10)..(11)
<223> Any conservative amino acid substitution

<220>
<221> MOD_RES
<222> (14)..(15)
<223> Any conservative amino acid substitution

<220>
<221> MOD_RES
<222> (17)..(17)
<223> Any conservative amino acid substitution

<220>
<221> MOD_RES
<222> (19)..(19)
<223> Any conservative amino acid substitution

<220>
<221> MOD_RES
<222> (22)..(27)
<223> Any conservative amino acid substitution

<220>
<221> MOD_RES
<222> (30)..(30)
<223> Any conservative amino acid substitution

<220>
<221> MOD_RES
<222> (32)..(32)
<223> Any conservative amino acid substitution

<220>
<221> MOD_RES
<222> (34)..(34)
<223> Any conservative amino acid substitution

<220>
<221> MOD_RES
<222> (37)..(38)
<223> Any conservative amino acid substitution

<220>
<221> MOD_RES
<222> (40)..(44)
<223> Any conservative amino acid substitution

<400> 22
Xaa Xaa Ile Xaa Ile Xaa Xaa Xaa Leu Xaa Xaa Leu Leu Xaa Xaa Tyr 
1               5                   10                  15      


Xaa Val Xaa Val Leu Xaa Xaa Xaa Xaa Xaa Xaa Leu Val Xaa Phe Xaa 
            20                  25                  30          


Val Xaa Tyr Phe Xaa Xaa Leu Xaa Xaa Xaa Xaa Xaa 
        35                  40                  


<210> 23
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide


<220>
<221> MOD_RES
<222> (1)..(5)
<223> Any conservative amino acid substitution

<220>
<221> MOD_RES
<222> (7)..(8)
<223> Any conservative amino acid substitution

<220>
<221> MOD_RES
<222> (11)..(12)
<223> Any conservative amino acid substitution

<220>
<221> MOD_RES
<222> (15)..(17)
<223> Any conservative amino acid substitution

<400> 23
Xaa Xaa Xaa Xaa Xaa Ala Xaa Xaa Ile Val Xaa Xaa Ala Ile Xaa Xaa 
1               5                   10                  15      


Xaa 
    


<210> 24
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 24
Gln Ile Glu Tyr Val Ala Lys Gln Ile Val Asp Tyr Ala Ile His Gln 
1               5                   10                  15      


Ala 
    


<210> 25
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 25
Gln Ile Glu Tyr Lys Ala Lys Gln Ile Val Asp His Ala Ile His Gln 
1               5                   10                  15      


Ala 
    


<210> 26
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 26
Gln Ile Glu Tyr His Ala Lys Gln Ile Val Asp His Ala Ile His Gln 
1               5                   10                  15      


Ala 
    


<210> 27
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 27
Gln Ile Glu Tyr Val Ala Lys Gln Ile Val Asp His Ala Ile His Gln 
1               5                   10                  15      


Ala 
    


<210> 28
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 28
Pro Leu Glu Tyr Gln Ala Gly Leu Leu Val Gln Asn Ala Ile Gln Gln 
1               5                   10                  15      


Ala Ile 
        


<210> 29
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 29
Leu Leu Ile Glu Thr Ala Ser Ser Leu Val Lys Asn Ala Ile Gln Leu 
1               5                   10                  15      


Ser Ile 
        


<210> 30
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 30
Leu Ile Glu Glu Ala Ala Ser Arg Ile Val Asp Ala Val Ile Glu Gln 
1               5                   10                  15      


Val Lys 
        


<210> 31
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 31
Ala Leu Tyr Gln Phe Ala Asp Arg Phe Ser Glu Leu Val Ile Ser Glu 
1               5                   10                  15      


Ala Leu 
        


<210> 32
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 32
Leu Glu Gln Val Ala Asn Gln Leu Ala Asp Gln Ile Ile Lys Glu Ala 
1               5                   10                  15      


Thr 
    


<210> 33
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 33
Phe Glu Glu Leu Ala Trp Lys Ile Ala Lys Met Ile Trp Ser Asp Val 
1               5                   10                  15      


Phe 
    


<210> 34
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 34
Glu Leu Val Arg Leu Ser Lys Arg Leu Val Glu Asn Ala Val Leu Lys 
1               5                   10                  15      


Ala Val 
        


<210> 35
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 35
Thr Ala Glu Glu Val Ser Ala Arg Ile Val Gln Val Val Thr Ala Glu 
1               5                   10                  15      


Ala Val 
        


<210> 36
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 36
Gln Ile Lys Gln Ala Ala Phe Gln Leu Ile Ser Gln Val Ile Leu Glu 
1               5                   10                  15      


Ala Thr 
        


<210> 37
<211> 16
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 37
Leu Ala Trp Lys Ile Ala Lys Met Ile Val Ser Asp Val Met Gln Gln 
1               5                   10                  15      


<210> 38
<211> 24
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 38
Asp Leu Ile Glu Glu Ala Ala Ser Arg Ile Val Asp Ala Val Ile Glu 
1               5                   10                  15      


Gln Val Lys Ala Ala Gly Ala Tyr 
            20                  


<210> 39
<211> 18
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 39
Leu Glu Gln Tyr Ala Asn Gln Leu Ala Asp Gln Ile Ile Lys Glu Ala 
1               5                   10                  15      


Thr Glu 
        


<210> 40
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 40
Phe Glu Glu Leu Ala Trp Lys Ile Ala Lys Met Ile Trp Ser Asp Val 
1               5                   10                  15      


Phe Gln Gln Cys 
            20  


<210> 41
<211> 17
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 41
Gln Ile Glu Tyr Leu Ala Lys Gln Ile Pro Asp Asn Ala Ile Gln Gln 
1               5                   10                  15      


Ala 
    


<210> 42
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 42
Lys Gly Ala Asp Leu Ile Glu Glu Ala Ala Ser Arg Ile Val Asp Ala 
1               5                   10                  15      


Val Ile Glu Gln Val Lys Ala Ala Gly 
            20                  25  


<210> 43
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 43
Lys Gly Ala Asp Leu Ile Glu Glu Ala Ala Ser Arg Ile Pro Asp Ala 
1               5                   10                  15      


Pro Ile Glu Gln Val Lys Ala Ala Gly 
            20                  25  


<210> 44
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 44
Pro Glu Asp Ala Glu Leu Val Arg Leu Ser Lys Arg Leu Val Glu Asn 
1               5                   10                  15      


Ala Val Leu Lys Ala Val Gln Gln Tyr 
            20                  25  


<210> 45
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 45
Pro Glu Asp Ala Glu Leu Val Arg Thr Ser Lys Arg Leu Val Glu Asn 
1               5                   10                  15      


Ala Val Leu Lys Ala Val Gln Gln Tyr 
            20                  25  


<210> 46
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 46
Pro Glu Asp Ala Glu Leu Val Arg Leu Ser Lys Arg Asp Val Glu Asn 
1               5                   10                  15      


Ala Val Leu Lys Ala Val Gln Gln Tyr 
            20                  25  


<210> 47
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 47
Pro Glu Asp Ala Glu Leu Val Arg Leu Ser Lys Arg Leu Pro Glu Asn 
1               5                   10                  15      


Ala Val Leu Lys Ala Val Gln Gln Tyr 
            20                  25  


<210> 48
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 48
Pro Glu Asp Ala Glu Leu Val Arg Leu Ser Lys Arg Leu Pro Glu Asn 
1               5                   10                  15      


Ala Pro Leu Lys Ala Val Gln Gln Tyr 
            20                  25  


<210> 49
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 49
Pro Glu Asp Ala Glu Leu Val Arg Leu Ser Lys Arg Leu Val Glu Asn 
1               5                   10                  15      


Ala Val Glu Lys Ala Val Gln Gln Tyr 
            20                  25  


<210> 50
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 50
Glu Glu Gly Leu Asp Arg Asn Glu Glu Ile Lys Arg Ala Ala Phe Gln 
1               5                   10                  15      


Ile Ile Ser Gln Val Ile Ser Glu Ala 
            20                  25  


<210> 51
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 51
Leu Val Asp Asp Pro Leu Glu Tyr Gln Ala Gly Leu Leu Val Gln Asn 
1               5                   10                  15      


Ala Ile Gln Gln Ala Ile Ala Glu Gln 
            20                  25  


<210> 52
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 52
Gln Tyr Glu Thr Leu Leu Ile Glu Thr Ala Ser Ser Leu Val Lys Asn 
1               5                   10                  15      


Ala Ile Gln Leu Ser Ile Glu Gln Leu 
            20                  25  


<210> 53
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 53
Leu Glu Lys Gln Tyr Gln Glu Gln Leu Glu Glu Glu Val Ala Lys Val 
1               5                   10                  15      


Ile Val Ser Met Ser Ile Ala Phe Ala 
            20                  25  


<210> 54
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 54
Asn Thr Asp Glu Ala Gln Glu Glu Leu Ala Trp Lys Ile Ala Lys Met 
1               5                   10                  15      


Ile Val Ser Asp Ile Met Gln Gln Ala 
            20                  25  


<210> 55
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 55
Val Asn Leu Asp Lys Lys Ala Val Leu Ala Glu Lys Ile Val Ala Glu 
1               5                   10                  15      


Ala Ile Glu Lys Ala Glu Arg Glu Leu 
            20                  25  


<210> 56
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 56
Asn Gly Ile Leu Glu Leu Glu Thr Lys Ser Ser Lys Leu Val Gln Asn 
1               5                   10                  15      


Ile Ile Gln Thr Ala Val Asp Gln Phe 
            20                  25  


<210> 57
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 57
Thr Gln Asp Lys Asn Tyr Glu Asp Glu Leu Thr Gln Val Ala Leu Ala 
1               5                   10                  15      


Leu Val Glu Asp Val Ile Asn Tyr Ala 
            20                  25  


<210> 58
<211> 25
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 58
Glu Thr Ser Ala Lys Asp Asn Ile Asn Ile Glu Glu Ala Ala Arg Phe 
1               5                   10                  15      


Leu Val Glu Lys Ile Leu Val Asn His 
            20                  25  


<210> 59
<211> 44
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Any conservative amino acid substitution

<220>
<221> MOD_RES
<222> (4)..(4)
<223> Any conservative amino acid substitution

<220>
<221> MOD_RES
<222> (7)..(7)
<223> Any conservative amino acid substitution

<220>
<221> MOD_RES
<222> (10)..(10)
<223> Any conservative amino acid substitution

<220>
<221> MOD_RES
<222> (18)..(18)
<223> Any conservative amino acid substitution

<220>
<221> MOD_RES
<222> (23)..(23)
<223> Any conservative amino acid substitution

<220>
<221> MOD_RES
<222> (26)..(26)
<223> Any conservative amino acid substitution

<220>
<221> MOD_RES
<222> (33)..(34)
<223> Any conservative amino acid substitution

<220>
<221> MOD_RES
<222> (37)..(38)
<223> Any conservative amino acid substitution

<220>
<221> MOD_RES
<222> (40)..(40)
<223> Any conservative amino acid substitution

<220>
<221> MOD_RES
<222> (42)..(42)
<223> Any conservative amino acid substitution

<220>
<221> MOD_RES
<222> (44)..(44)
<223> Any conservative amino acid substitution

<400> 59
Xaa His Ile Xaa Ile Pro Xaa Gly Leu Xaa Glu Leu Leu Gln Gly Tyr 
1               5                   10                  15      


Thr Xaa Glu Val Leu Arg Xaa Gln Pro Xaa Asp Leu Val Glu Phe Ala 
            20                  25                  30          


Xaa Xaa Tyr Phe Xaa Xaa Leu Xaa Glu Xaa Arg Xaa 
        35                  40                  


<210> 60
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 60
Gln Lys Ser Leu Ser Leu Ser Pro Gly Leu Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Cys Gly 
            20      


<210> 61
<211> 21
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 61
Gln Lys Ser Leu Ser Leu Ser Pro Gly Ala Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Cys Gly 
            20      


<210> 62
<211> 20
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 62
Gln Lys Ser Leu Ser Leu Ser Pro Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10                  15      


Gly Gly Cys Gly 
            20  


<210> 63
<211> 20
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 63
gaacctcgcg gacagttaag                                                   20


<210> 64
<211> 53
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 64
ggatcctccg ccgccgcagc tcttaggttt cttgtccacc ttggtgttgc tgg              53


<210> 65
<211> 55
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide

<400> 65
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser His Ile Gln Ile 
1               5                   10                  15      


Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr Thr Val Glu Val Leu 
            20                  25                  30          


Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ala Val Glu Tyr Phe Thr 
        35                  40                  45              


Arg Leu Arg Glu Ala Arg Ala 
    50                  55  


<210> 66
<211> 92
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 66
gtggcgggtc tggcggaggt ggcagccaca tccagatccc gccggggctc acggagctgc       60

tgcagggcta cacggtggag gtgctgcgac ag                                     92


<210> 67
<211> 92
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 67
gcgcgagctt ctctcaggcg ggtgaagtac tccactgcga attcgacgag gtcaggcggc       60

tgctgtcgca gcacctccac cgtgtagccc tg                                     92


<210> 68
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 68
ggatccggag gtggcgggtc tggcggaggt                                        30


<210> 69
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 69
cggccgtcaa gcgcgagctt ctctcaggcg                                        30


<210> 70
<211> 29
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 70
Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gln Ile Glu Tyr 
1               5                   10                  15      


Leu Ala Lys Gln Ile Val Asp Asn Ala Ile Gln Gln Ala 
            20                  25                  


<210> 71
<211> 96
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 71
ggatccggag gtggcgggtc tggcggaggt ggcagccaga tcgagtacct ggccaagcag       60

atcgtggaca acgccatcca gcaggcctga cggccg                                 96


<210> 72
<211> 96
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 72
cggccgtcag gcctgctgga tggcgttgtc cacgatctgc ttggccaggt actcgatctg       60

gctgccacct ccgccagacc cgccacctcc ggatcc                                 96


<210> 73
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 73
ggatccggag gtggcgggtc tggcggaggt                                        30


<210> 74
<211> 22
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 74
cggccgtcag gcctgctgga tg                                                22


<210> 75
<211> 28
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 75
ccatgggcag ccacatccag atcccgcc                                          28


<210> 76
<211> 55
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 76
ggatccgcca cctccagatc ctccgccgcc agcgcgagct tctctcaggc gggtg            55


<210> 77
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 77
ggatccggcg gaggtggctc tgaggtccaa ctggtggaga gcgg                        44


<210> 78
<211> 30
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 78
cggccgtcag cagctcttag gtttcttgtc                                        30


<210> 79
<211> 48
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 79
catgtgcggc cacatccaga tcccgccggg gctcacggag ctgctgca                    48


<210> 80
<211> 40
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 80
gcagctccgt gagccccggc gggatctgga tgtggccgca                             40


<210> 81
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 81
Gly Gly Gly Gly Ser Gly Gly Gly Cys Gly 
1               5                   10  


<210> 82
<211> 73
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 82
gatccggagg tggcgggtct ggcggaggtt gcggccacat ccagatcccg ccggggctca       60

cggagctgct gca                                                          73


<210> 83
<211> 65
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 83
gcagctccgt gagccccggc gggatctgga tgtggccgca acctccgcca gacccgccac       60

ctccg                                                                   65


<210> 84
<211> 93
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 84
gatccggagg tggcgggtct ggcggatgtg gccagatcga gtacctggcc aagcagatcg       60

tggacaacgc catccagcag gccggctgct gaa                                    93


<210> 85
<211> 89
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      oligonucleotide

<400> 85
ttcagcagcc ggcctgctgg atggcgttgt ccacgatctg cttggccagg tactcgatct       60

ggccacatcc gccagacccg ccacctccg                                         89


<210> 86
<211> 24
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 86
agatctggcg cacctgaact cctg                                              24


<210> 87
<211> 33
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 87
gaattcggat cctttacccg gagacaggga gag                                    33


<210> 88
<211> 139
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 88
tggctaacgt ttcagaagaa acatatcacg aatacacgag atgtagactg ggacaatata       60

atgtctacga atctgtttca ctgtaaggat aagaatacct ttatatacag tcggccagag      120

cctgtaaagg ctatctgta                                                   139


<210> 89
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 89
aagcttcata tgcaggattg gctaacgttt cagaagaaa                              39


<210> 90
<211> 44
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 90
cttactcgcg ataatgcctt tacagatagc ctttacaggc tctg                        44


<210> 91
<211> 137
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polynucleotide

<400> 91
tgctgactac ttccgagttc tatctgtccg attgcaatgt gacttcacgg ccctgcaaat       60

ataagctgaa gaaaagcact aacaaatttt gcgtaacttg cgagaaccag gctcctgtac      120

atttcgttgg agtcggg                                                     137


<210> 92
<211> 42
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 92
attatcgcga gtaagaacgt gctgactact tccgagttct at                          42


<210> 93
<211> 39
<212> DNA
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      primer

<400> 93
ttaggatcct tagcagctcc cgactccaac gaaatgtac                              39


<210> 94
<211> 9
<212> PRT
<213> Pseudomonas sp.

<400> 94
Thr Arg His Arg Gln Pro Arg Gly Trp 
1               5                   


<210> 95
<211> 12
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 95
Ser Thr Tyr Tyr Gly Gly Asp Trp Tyr Phe Asp Val 
1               5                   10          


<210> 96
<211> 5
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 96
Gly Gly Gly Gly Ser 
1               5   


<210> 97
<211> 10
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      peptide

<400> 97
Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10  


<210> 98
<211> 164
<212> PRT
<213> Artificial Sequence

<220>
<223> Description of Artificial Sequence: Synthetic
      polypeptide


<220>
<221> MOD_RES
<222> (1)..(1)
<223> Pyroglutamate

<400> 98
Gln Asp Trp Leu Thr Phe Gln Lys Lys His Ile Thr Asn Thr Arg Asp 
1               5                   10                  15      


Val Asp Cys Asp Asn Ile Met Ser Thr Asn Leu Phe His Cys Lys Asp 
            20                  25                  30          


Lys Asn Thr Phe Ile Tyr Ser Arg Pro Glu Pro Val Lys Ala Ile Cys 
        35                  40                  45              


Lys Gly Ile Ile Ala Ser Lys Asn Val Leu Thr Thr Ser Glu Phe Tyr 
    50                  55                  60                  


Leu Ser Asp Cys Asn Val Thr Ser Arg Pro Cys Lys Tyr Lys Leu Lys 
65                  70                  75                  80  


Lys Ser Thr Asn Lys Phe Cys Val Thr Cys Glu Asn Gln Ala Pro Val 
                85                  90                  95      


His Phe Val Gly Val Gly Ser Cys Gly Gly Gly Gly Ser Leu Glu Cys 
            100                 105                 110         


Gly His Ile Gln Ile Pro Pro Gly Leu Thr Glu Leu Leu Gln Gly Tyr 
        115                 120                 125             


Thr Val Glu Val Leu Arg Gln Gln Pro Pro Asp Leu Val Glu Phe Ala 
    130                 135                 140                 


Val Glu Tyr Phe Thr Arg Leu Arg Glu Ala Arg Ala Val Glu His His 
145                 150                 155                 160 


His His His His 
                



