
                                SEQUENCE LISTING

<110> GENENTECH, INC.
      BUNTING, Stuart
      BULLENS, Sherron
      CARLSSON, Roland
      FRENDEUS, Bjorn
      GLAZER, Steven
      GROVE, Kevin
      VAN BRUGGEN, Nick

<120> METHODS OF TREATMENT USING ANTI-OXIDIZED
      LDL ANTIBODIES

<130> 146392006740

<140> PCT/US2010/047030   
<141> 2010-08-27  

<150> US 61/238,114       
<151> 2009-08-28  

<160> 144

<170> FastSEQ for Windows Version 4.0

<210> 1
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 1
Phe Leu Asp Thr Val Tyr Gly Asn Cys Ser Thr His Phe Thr Val Lys
 1               5                  10                  15      
Thr Arg Lys Gly
            20  


<210> 2
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 2
Pro Gln Cys Ser Thr His Ile Leu Gln Trp Leu Lys Arg Val His Ala
 1               5                  10                  15      
Asn Pro Leu Leu
            20  


<210> 3
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 3
Val Ile Ser Ile Pro Arg Leu Gln Ala Glu Ala Arg Ser Glu Ile Leu
 1               5                  10                  15      
Ala His Trp Ser
            20  


<210> 4
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 4
Lys Leu Val Lys Glu Ala Leu Lys Glu Ser Gln Leu Pro Thr Val Met
 1               5                  10                  15      
Asp Phe Arg Lys
            20  


<210> 5
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 5
Leu Lys Phe Val Thr Gln Ala Glu Gly Ala Lys Gln Thr Glu Ala Thr
 1               5                  10                  15      
Met Thr Phe Lys
            20  



<210> 6
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 6
Asp Gly Ser Leu Arg His Lys Phe Leu Asp Ser Asn Ile Lys Phe Ser
 1               5                  10                  15      
His Val Glu Lys
            20  


<210> 7
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 7
Lys Gly Thr Tyr Gly Leu Ser Cys Gln Arg Asp Pro Asn Thr Gly Arg
 1               5                  10                  15      
Leu Asn Gly Glu
            20  


<210> 8
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 8
Arg Leu Asn Gly Glu Ser Asn Leu Arg Phe Asn Ser Ser Tyr Leu Gln
 1               5                  10                  15      
Gly Thr Asn Gln
            20  


<210> 9
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 9
Ser Leu Thr Ser Thr Ser Asp Leu Gln Ser Gly Ile Ile Lys Asn Thr
 1               5                  10                  15      
Ala Ser Leu Lys
            20  


<210> 10
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 10
Thr Ala Ser Leu Lys Tyr Glu Asn Tyr Glu Leu Thr Leu Lys Ser Asp
 1               5                  10                  15      
Thr Asn Gly Lys
            20  


<210> 11
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 11
Asp Met Thr Phe Ser Lys Gln Asn Ala Leu Leu Arg Ser Glu Tyr Gln
 1               5                  10                  15      
Ala Asp Tyr Glu
            20  


<210> 12
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 12
Met Lys Val Lys Ile Ile Arg Thr Ile Asp Gln Met Gln Asn Ser Glu
 1               5                  10                  15      
Leu Gln Trp Pro
            20  


<210> 13
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 13
Ile Ala Leu Asp Asp Ala Lys Ile Asn Phe Asn Glu Lys Leu Ser Gln
 1               5                  10                  15      
Leu Gln Thr Tyr
            20  


<210> 14
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 14
Lys Thr Thr Lys Gln Ser Phe Asp Leu Ser Val Lys Ala Gln Tyr Lys
 1               5                  10                  15      
Lys Asn Lys His
            20  


<210> 15
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 15
Glu Glu Glu Met Leu Glu Asn Val Ser Leu Val Cys Pro Lys Asp Ala
 1               5                  10                  15      
Thr Arg Phe Lys
            20  


<210> 16
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 16
Gly Ser Thr Ser His His Leu Val Ser Arg Lys Ser Ile Ser Ala Ala
 1               5                  10                  15      
Leu Glu His Lys
            20  


<210> 17
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 17
Ile Glu Asn Ile Asp Phe Asn Lys Ser Gly Ser Ser Thr Ala Ser Trp
 1               5                  10                  15      
Ile Gln Asn Val
            20  


<210> 18
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 18
Ile Arg Glu Val Thr Gln Arg Leu Asn Gly Glu Ile Gln Ala Leu Glu
 1               5                  10                  15      
Leu Pro Gln Lys
            20  


<210> 19
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 19
Glu Val Asp Val Leu Thr Lys Tyr Ser Gln Pro Glu Asp Ser Leu Ile
 1               5                  10                  15      
Pro Phe Phe Glu
            20  


<210> 20
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 20
His Thr Phe Leu Ile Tyr Ile Thr Glu Leu Leu Lys Lys Leu Gln Ser
 1               5                  10                  15      
Thr Thr Val Met
            20  


<210> 21
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 21
Leu Leu Asp Ile Ala Asn Tyr Leu Met Glu Gln Ile Gln Asp Asp Cys
 1               5                  10                  15      
Thr Gly Asp Glu
            20  


<210> 22
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 22
Cys Thr Gly Asp Glu Asp Tyr Thr Tyr Leu Ile Leu Arg Val Ile Gly
 1               5                  10                  15      
Asn Met Gly Gln
            20  


<210> 23
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 23
Gly Asn Met Gly Gln Thr Met Glu Gln Leu Thr Pro Glu Leu Lys Ser
 1               5                  10                  15      
Ser Ile Leu Lys
            20  


<210> 24
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 24
Ser Ser Ile Leu Lys Cys Val Gln Ser Thr Lys Pro Ser Leu Met Ile
 1               5                  10                  15      
Gln Lys Ala Ala
            20  


<210> 25
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 25
Ile Gln Lys Ala Ala Ile Gln Ala Leu Arg Lys Met Glu Pro Lys Asp
 1               5                  10                  15      
Lys Asp Gln Glu
            20  


<210> 26
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 26
Arg Leu Asn Gly Glu Ser Asn Leu Arg Phe Asn Ser Ser Tyr Leu Gln
 1               5                  10                  15      
Gly Thr Asn Gln
            20  


<210> 27
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 27
Ser Leu Asn Ser His Gly Leu Glu Leu Asn Ala Asp Ile Leu Gly Thr
 1               5                  10                  15      
Asp Lys Ile Asn
            20  


<210> 28
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 28
Trp Ile Gln Asn Val Asp Thr Lys Tyr Gln Ile Arg Ile Gln Ile Gln
 1               5                  10                  15      
Glu Lys Leu Gln
            20  


<210> 29
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 29
Thr Tyr Ile Ser Asp Trp Trp Thr Leu Ala Ala Lys Asn Leu Thr Asp
 1               5                  10                  15      
Phe Ala Glu Gln
            20  


<210> 30
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 30
Glu Ala Thr Leu Gln Arg Ile Tyr Ser Leu Trp Glu His Ser Thr Lys
 1               5                  10                  15      
Asn His Leu Gln
            20  


<210> 31
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 31
Ala Leu Leu Val Pro Pro Glu Thr Glu Glu Ala Lys Gln Val Leu Phe
 1               5                  10                  15      
Leu Asp Thr Val
            20  


<210> 32
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 32
Ile Glu Ile Gly Leu Glu Gly Lys Gly Phe Glu Pro Thr Leu Glu Ala
 1               5                  10                  15      
Leu Phe Gly Lys
            20  


<210> 33
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 33
Ser Gly Ala Ser Met Lys Leu Thr Thr Asn Gly Arg Phe Arg Glu His
 1               5                  10                  15      
Asn Ala Lys Phe
            20  


<210> 34
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 34
Asn Leu Ile Gly Asp Phe Glu Val Ala Glu Lys Ile Asn Ala Phe Arg
 1               5                  10                  15      
Ala Lys Val His
            20  


<210> 35
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 35
Gly His Ser Val Leu Thr Ala Lys Gly Met Ala Leu Phe Gly Glu Gly
 1               5                  10                  15      
Lys Ala Glu Phe
            20  


<210> 36
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 36
Phe Lys Ser Ser Val Ile Thr Leu Asn Thr Asn Ala Glu Leu Phe Asn
 1               5                  10                  15      
Gln Ser Asp Ile
            20  


<210> 37
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 37
Phe Pro Asp Leu Gly Gln Glu Val Ala Leu Asn Ala Asn Thr Lys Asn
 1               5                  10                  15      
Gln Lys Ile Arg
            20  


<210> 38
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 38
Ala Thr Arg Phe Lys His Leu Arg Lys Tyr Thr Tyr Asn Tyr Glu Ala
 1               5                  10                  15      
Glu Ser Ser Ser
            20  


<210> 39
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 39
Cys Ser Gly Ser Asn Thr Asn Ile Gly Lys Asn Tyr Val Ser
 1               5                  10                  


<210> 40
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 40
Ala Asn Ser Asn Arg Pro Ser
 1               5          


<210> 41
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 41
Cys Ala Ser Trp Asp Ala Ser Leu Asn Gly Trp Val
 1               5                  10          


<210> 42
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 42
Phe Ser Asn Ala Trp Met Ser Trp Val Arg Gln Ala Pro Gly
 1               5                  10                  


<210> 43
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 43
Ser Ser Ile Ser Val Gly Gly His Arg Thr Tyr Tyr Ala Asp Ser Val
 1               5                  10                  15      
Lys Gly Arg
            


<210> 44
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 44
Ala Arg Ile Arg Val Gly Pro Ser Gly Gly Ala Phe Asp Tyr
 1               5                  10                  


<210> 45
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 45
Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Ala Val Asn
 1               5                  10                  


<210> 46
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 46
Gly Asn Asp Arg Arg Pro Ser
 1               5          


<210> 47
<211> 10
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 47
Cys Gln Thr Trp Gly Thr Gly Arg Gly Val
 1               5                  10  


<210> 48
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 48
Phe Ser Asp Tyr Tyr Met Ser Trp Val Arg Gln Ala Pro Gly
 1               5                  10                  


<210> 49
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 49
Ser Gly Val Ser Trp Asn Gly Ser Arg Thr His Tyr Ala Asp Ser Val
 1               5                  10                  15      
Lys Gly Arg
            


<210> 50
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 50
Ala Arg Ala Ala Arg Tyr Ser Tyr Tyr Tyr Tyr Gly Met Asp Val
 1               5                  10                  15  


<210> 51
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 51
Cys Ser Gly Ser Ser Ser Ser Ile Gly Asn Asn Phe Val Ser
 1               5                  10                  


<210> 52
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 52
Asp Asn Asn Lys Arg Pro Ser
 1               5          


<210> 53
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 53
Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val
 1               5                  10          


<210> 54
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 54
Phe Ser Asn Ala Trp Met Ser Trp Val Arg Gln Ala Pro Gly
 1               5                  10                  


<210> 55
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 55
Ser Ser Ile Ser Thr Ser Ser Asn Tyr Ile Tyr Tyr Ala Asp Ser Val
 1               5                  10                  15      
Lys Gly Arg
            


<210> 56
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 56
Ala Arg Val Lys Lys Tyr Ser Ser Gly Trp Tyr Ser Asn Tyr Ala Phe
 1               5                  10                  15      
Asp Ile
        


<210> 57
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 57
Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly Glu Ser Val Ser
 1               5                  10                  


<210> 58
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 58
Ser Asn Asn Gln Arg Pro Ser
 1               5          


<210> 59
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 59
Cys Ala Ala Trp Asp Asp Ser Leu Asn Gly Trp Val
 1               5                  10          


<210> 60
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 60
Phe Ser Ser Tyr Ala Met Ser Trp Val Arg Gln Ala Pro Gly
 1               5                  10                  


<210> 61
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 61
Ser Ser Ile Ser Ser Ser Gly Arg Phe Ile Tyr Tyr Ala Asp Ser Met
 1               5                  10                  15      
Lys Gly Arg
            


<210> 62
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 62
Thr Arg Leu Arg Arg Gly Ser Tyr Phe Trp Ala Phe Asp Ile
 1               5                  10                  


<210> 63
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> IEIA8 Variable Heavy (VH) Region

<400> 63
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60
tcctgtgcag cctctggatt caccttcaat aacgcctgga tgagctgggt ccgccaggct 120
ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtagtta catatactac 180
gcagactcag tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gagagtcagt 300
aggtactact acggaccatc tttctacttt gactcctggg gccagggtac actggtcacc 360
gtgagcagc                                                         369

<210> 64
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> IEIA8 Variable Heavy (VH) Region

<400> 64
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Val Ser Arg Tyr Tyr Tyr Gly Pro Ser Phe Tyr Phe Asp Ser
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120             


<210> 65
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> IEIA8 Variable Light (VL) Region

<400> 65
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc 60
tcctgctctg gaagcaggtc caacattggg aataattatg tatcctggta tcagcagctc 120
ccaggaacgg cccccaaact cctcatctat ggtaacaaca atcggccctc aggggtccct 180
gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg 240
tccgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggtcattgg 300
gtgttcggcg gaggaaccaa gctgacggtc ctaggt                           336

<210> 66
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> IEIA8 Variable Light (VL) Region

<400> 66
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Arg Ser Asn Ile Gly Asn Asn
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Gly Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
                85                  90                  95      
Asn Gly His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110         


<210> 67
<211> 366
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> IEI-E3 Variable Heavy (VH) Region

<400> 67
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60
tcctgtgcgg cctctggatt caccttcagt gactactaca tgagctgggt ccgccaggct 120
cccgggaagg ggctggagtg ggtatcgggt gttagttgga atggcagtag gacgcactat 180
gcagactctg tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gagagcggct 300
aggtactcct actactacta cggtatggac gtctggggcc aaggtacact ggtcaccgtg 360
agcagc                                                            366

<210> 68
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> IEI-E3 Variable Heavy (VH) Region

<400> 68
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Gly Val Ser Trp Asn Gly Ser Arg Thr His Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ala Ala Arg Tyr Ser Tyr Tyr Tyr Tyr Gly Met Asp Val Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 69
<211> 327
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> IEI-E3 Variable Light (VL) Region

<400> 69
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc 60
tcctgttctg gaagcagctc caacatcgga aataatgctg taaactggta tcagcagctc 120
ccaggaacgg cccccaaact cctcatctat gggaatgatc ggcggccctc aggggtccct 180
gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg 240
tccgaggatg aggctgatta ttactgtcag acctggggca ctggccgggg ggtattcggc 300
ggaggaacca agctgacggt cctaggt                                     327

<210> 70
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> IEI-E3 Variable Light (VL) Region

<400> 70
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
            20                  25                  30          
Ala Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Gly Asn Asp Arg Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Thr Trp Gly Thr Gly Arg
                85                  90                  95      
Gly Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 


<210> 71
<211> 366
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> IEI-G8 Variable Heavy (VH) Region

<400> 71
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60
tcctgtgcag cctctggatt cacctttagt agctattgga tgagctgggt ccgccaggct 120
ccagggaagg ggctggagtg ggtctcaagt atcagtggta gtggtcgtag gacatactac 180
gcagactccg tgcagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gagattggtc 300
tcctatggtt cggggagttt cggttttgac tactggggcc aaggtacact ggtcaccgtg 360
agcagc                                                            366

<210> 72
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> IEI-G8 Variable Heavy (VH) Region

<400> 72
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Arg Arg Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Gln Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Leu Val Ser Tyr Gly Ser Gly Ser Phe Gly Phe Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 73
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> IEI-G8 Variable Light (VL) Region

<400> 73
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc 60
tcttgttctg gaagcagctc caatatcgga agtaattatg tatcctggta tcagcagctc 120
ccaggaacgg cccccaaact cctcatctat ggtaactaca atcggccctc aggggtccct 180
gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg 240
tccgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgag tggttgggtg 300
ttcggcggag gaaccaagct gacggtccta ggt                              333

<210> 74
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> IEI-G8 Variable Light (VL) Region

<400> 74
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Gly Asn Tyr Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
                85                  90                  95      
Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110 


<210> 75
<211> 378
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> IEI-D8 Variable Heavy (VH) Region

<400> 75
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60
tcctgtgcag cctctggatt caccttcagt aacgcctgga tgagctgggt ccgccaggtt 120
ccagggaagg ggctggagtg ggtctcaact cttggtggta gtggtggtgg tagcacatac 180
tacgcagact ccgtgaaggg ccggttcacc atctccagag acaattccaa gaacacgctg 240
tatctgcaaa tgaacagcct gagagccgag gacactgccg tgtattactg tgcgaagtta 300
ggggggcgat cccgatatgg gcggtggccc cgccaatttg actactgggg ccaaggtaca 360
ctggtcaccg tgagcagc                                               378

<210> 76
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> IEI-D8 Variable Heavy (VH) Region

<400> 76
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Val Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Thr Leu Gly Gly Ser Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser
    50                  55                  60                  
Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu
65                  70                  75                  80  
Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr
                85                  90                  95      
Cys Ala Lys Leu Gly Gly Arg Ser Arg Tyr Gly Arg Trp Pro Arg Gln
            100                 105                 110         
Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125     


<210> 77
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> IEI-D8 Variable Light (VL) Region

<400> 77
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc 60
tcctgctctg gaagcagctc caacattgga aataactatg tatcctggta tcagcagctc 120
ccaggaacgg cccccaaact cctcatctat agtaataatc agcggccctc aggggtccct 180
gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg 240
tccgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgag tcattggctg 300
ttcggcggag gaaccaagct gacggtccta ggt                              333

<210> 78
<211> 110
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> IEI-D8 Variable Light (VL) Region

<400> 78
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
                85                  90                  95      
Ser His Trp Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu
            100                 105                 110 


<210> 79
<211> 372
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> KTT-D6 Variable Heavy (VH) Region

<400> 79
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60
tcctgtgcag cctctggatt caccttcagt gactactaca tgagctggat ccgccaggct 120
ccagggaagg ggctggagtg ggtctcaagt atcagtggcc gtgggggtag ttcctactac 180
gcagactccg tgaggggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gagactttcc 300
tacagctatg gttacgaggg ggcctactac tttgactact ggggccaggg tacactggtc 360
accgtgagca gc                                                     372

<210> 80
<211> 124
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> KTT-D6 Variable Heavy (VH) Region

<400> 80
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asp Tyr
            20                  25                  30          
Tyr Met Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ser Ile Ser Gly Arg Gly Gly Ser Ser Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Arg Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Leu Ser Tyr Ser Tyr Gly Tyr Glu Gly Ala Tyr Tyr Phe Asp
            100                 105                 110         
Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 


<210> 81
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> KTT-D6 Variable Light (VL) Region

<400> 81
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc 60
tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta tcagcagctc 120
ccaggaacgg cccccaaact cctcatctat aggaataatc agcggccctc aggggtccct 180
gaccgattct ctggctccaa gtctggcacc ttagcctccc tggccatcag tgggctccgg 240
tccgaggatg aggctgatta ttactgtgca acctgggatg acagcctgaa tggttgggtg 300
ttcggcggag gaaccaagct gacggtccta ggt                              333

<210> 82
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> KTT-D6 Variable Light (VL) Region

<400> 82
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Leu Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Asp Ser Leu
                85                  90                  95      
Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110     


<210> 83
<211> 363
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> KTT-B8 Variable Heavy (VH) Region

<400> 83
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60
tcctgtgcag cctctggatt cacctttagc agctatgcca tgagctgggt ccgccaggct 120
ccagggaagg ggctggagtg ggtctcatcc attagtagta gtggtcgttt catttactac 180
gcagactcaa tgaagggccg cttcaccatc tccagagaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtac gaggctccgg 300
agagggagct acttctgggc ttttgatatc tggggccaag gtacactggt caccgtgagc 360
agc                                                               363

<210> 84
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> KTT-B8 Variable Heavy (VH) Region

<400> 84
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Ala Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ser Ile Ser Ser Ser Gly Arg Phe Ile Tyr Tyr Ala Asp Ser Met
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Thr Arg Leu Arg Arg Gly Ser Tyr Phe Trp Ala Phe Asp Ile Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120     


<210> 85
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> KTT-B8 Variable Light (VL) Region

<400> 85
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc 60
tcctgttctg gaagcagctc caacattggc ggtgagtctg tatcctggta tcagcagctc 120
ccaggaacgg cccccaaact cctcatctat agtaataatc agcggccctc aggggtccct 180
gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg 240
tccgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggttgggtg 300
ttcggcggag gaaccaagct gacggtccta ggt                              333

<210> 86
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> KTT-B8 Variable Light (VL) Region

<400> 86
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Gly Glu
            20                  25                  30          
Ser Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Ser Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
                85                  90                  95      
Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110     


<210> 87
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 1-B12 Variable Heavy (VH) Region

<400> 87
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60
tcctgtgcag cctctggatt cacctttaga acgtattgga tgacctgggt ccgccaggct 120
ccagggaagg ggctggagtg ggtctcatct attagcagta gcagtaatta catattctac 180
gcagactcag tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gagactcaga 300
cggagcagct ggtacggggg gtactggttc gacccctggg gccaaggtac actggtcacc 360
gtgagctca                                                         369

<210> 88
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 1-B12 Variable Heavy (VH) Region

<400> 88
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Thr Tyr
            20                  25                  30          
Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ser Ile Ser Ser Ser Ser Asn Tyr Ile Phe Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Leu Arg Arg Ser Ser Trp Tyr Gly Gly Tyr Trp Phe Asp Pro
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120             


<210> 89
<211> 336
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 1-B12 Variable Light (VL) Region

<400> 89
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc 60
tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta tcagcagctc 120
ccaggaacgg cccccaaact cctcatctat aggaataatc agcggccctc aggggtccct 180
gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg 240
tccgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggtcattgg 300
gtgttcggcg gaggaaccaa gctgacggtc ctaggt                           336

<210> 90
<211> 112
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 1-B12 Variable Light (VL) Region

<400> 90
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
                85                  90                  95      
Asn Gly His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110         


<210> 91
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 1-C07 Variable Heavy (VH) Region

<400> 91
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60
tcctgtgcag cctctggatt caccttcagt agcaactaca tgagctgggt ccgccaggct 120
ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtagtta catatactac 180
gcagactcag tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gagagtaggc 300
cggtataact ggaagacggg gcatgctttt gatatctggg gccagggtac actggtcacc 360
gtgagctca                                                         369

<210> 92
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 1-C07 Variable Heavy (VH) Region

<400> 92
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Asn
            20                  25                  30          
Tyr Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Val Gly Arg Tyr Asn Trp Lys Thr Gly His Ala Phe Asp Ile
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120             


<210> 93
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 1-C07 Variable Light (VL) Region

<400> 93
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc 60
tcctgctctg gaaggaccta caacattgga aataattatg tatcgtggta tcagcagctc 120
ccaggaacgg cccccaaact cctcatctat ggtaacatca atcggccctc aggggtccct 180
gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg 240
tccgaggatg aggctgatta ttactgtgca gcatgggatg tcaggctgaa tggttgggtg 300
ttcggcggag gaaccaagct gacggtccta ggt                              333

<210> 94
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 1-C07 Variable Light (VL) Region

<400> 94
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Arg Thr Tyr Asn Ile Gly Asn Asn
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Gly Asn Ile Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Val Arg Leu
                85                  90                  95      
Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110     


<210> 95
<211> 381
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 1-C12 Variable Heavy (VH) Region

<400> 95
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60
tcctgtgcag cctctggatt caccttccgt gactactacg tgagctggat ccgccaggct 120
ccagggaagg ggctggagtg ggtctcaagt attagtggta gtgggggtag gacatactac 180
gcagactccg tggagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgag agccgaggac actgccatgt attactgtgc cagagtatcc 300
gcccttcgga gacccatgac tacagtaact acttactggt tcgacccctg gggccaaggt 360
acactggtca ccgtgagctc a                                           381

<210> 96
<211> 127
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 1-C12 Variable Heavy (VH) Region

<400> 96
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Arg Asp Tyr
            20                  25                  30          
Tyr Val Ser Trp Ile Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ser Ile Ser Gly Ser Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Glu Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Met Tyr Tyr Cys
                85                  90                  95      
Ala Arg Val Ser Ala Leu Arg Arg Pro Met Thr Thr Val Thr Thr Tyr
            100                 105                 110         
Trp Phe Asp Pro Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125         


<210> 97
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 1-C12 Variable Light (VL) Region

<400> 97
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc 60
tcctgctctg gaaggagctc caacattggg aatagttatg tctcctggta tcagcagctc 120
ccaggaacgg cccccaaact cctcatctat aggaataatc agcggccctc aggggtccct 180
gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg 240
tccgaggatg aggctgatta ttactgtgca ggatgggatg acaccctgcg tgcttgggtg 300
ttcggcggag gaaccaagct gacggtccta ggt                              333

<210> 98
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 1-C12 Variable Light (VL) Region

<400> 98
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Arg Ser Ser Asn Ile Gly Asn Ser
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Arg Asn Asn Gln Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Gly Trp Asp Asp Thr Leu
                85                  90                  95      
Arg Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110     


<210> 99
<211> 360
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> I-G10 Variable Heavy (VH) Region

<400> 99
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60
tcctgtgcag cctctggatt caccttcagt aacgcctgga tgagctgggt ccgccaggct 120
ccagggaagg ggctggagtg ggtctccgct attagtggta gtggtaacac atactatgca 180
gactccgtga agggccggtt caccatctcc agagacaatt ccaagaacac gctgtatctg 240
caaatgaaca gcctgagagc cgaggacact gccgtgtatt actgtgcgag agcctcccac 300
cgtatattag gttatgcttt tgatatctgg ggccagggta cactggtcac cgtgagctca 360


<210> 100
<211> 120
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> I-G10 Variable Heavy (VH) Region

<400> 100
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ala Ile Ser Gly Ser Gly Asn Thr Tyr Tyr Ala Asp Ser Val Lys
    50                  55                  60                  
Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu
65                  70                  75                  80  
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala
                85                  90                  95      
Arg Ala Ser His Arg Ile Leu Gly Tyr Ala Phe Asp Ile Trp Gly Gln
            100                 105                 110         
Gly Thr Leu Val Thr Val Ser Ser
        115                 120 


<210> 101
<211> 328
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> I-G10 Variable Light (VL) Region

<400> 101
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc 60
tcttgttctg gaagccgctc caacatcggg agaaatgctg ttagttggta tcagcagctc 120
ccaggaacgg cccccaaact cctcatctat gctaacagca atcggccctc aggggtccct 180
gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg 240
tccgaggatg aggctgatta ttactgtgca gcatgggatg gcagcctgaa tggttgggtg 300
ttcggcggag gaaccaagct gacggtcc                                    328

<210> 102
<211> 109
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> I-G10 Variable Light (VL) Region

<400> 102
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Arg Ser Asn Ile Gly Arg Asn
            20                  25                  30          
Ala Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Ala Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Gly Ser Leu
                85                  90                  95      
Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val
            100                 105                 


<210> 103
<211> 363
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 2-D03 Variable Heavy (VH) Region

<400> 103
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60
tcctgtgcag cctctggatt caccttcagt aacgcctgga tgagctgggt ccgccaggct 120
ccagggaagg ggctggagtg ggtctcaagt attagtgttg gtggacatag gacatattat 180
gcagattccg tgaagggccg gtccaccatc tccagagaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc acggatacgg 300
gtgggtccgt ccggcggggc ctttgactac tggggccagg gtacactggt caccgtgagc 360
tca                                                               363

<210> 104
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 2-D03 Variable Heavy (VH) Region

<400> 104
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ser Ile Ser Val Gly Gly His Arg Thr Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Ser Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ile Arg Val Gly Pro Ser Gly Gly Ala Phe Asp Tyr Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120     


<210> 105
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 2-D03 Variable Light (VL) Region

<400> 105
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc 60
tcctgctctg gaagcaacac caacattggg aagaactatg tatcttggta tcagcagctc 120
ccaggaacgg cccccaaact cctcatctat gctaatagca atcggccctc aggggtccct 180
gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg 240
tccgaggatg aggctgatta ttactgtgcg tcatgggatg ccagcctgaa tggttgggta 300
ttcggcggag gaaccaagct gacggtccta ggt                              333

<210> 106
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 2-D03 Variable Light (VL) Region

<400> 106
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Asn Thr Asn Ile Gly Lys Asn
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Ala Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ser Trp Asp Ala Ser Leu
                85                  90                  95      
Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110     


<210> 107
<211> 378
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 2-F07 Variable Heavy (VH) Region

<400> 107
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60
tcctgtgcag cctctggatt caccttcagt aacgcctgga tgagctgggt ccgccaggct 120
ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtagtta catatactac 180
gcagactcag tgaagggccg atccaccatc tccagagaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gaggctcaca 300
aatattttga ctggttatta tacctcagga tatgcttttg atatctgggg ccaaggtaca 360
ctggtcaccg tgagctca                                               378

<210> 108
<211> 126
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 2-F07 Variable Heavy (VH) Region

<400> 108
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Ser Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Leu Thr Asn Ile Leu Thr Gly Tyr Tyr Thr Ser Gly Tyr Ala
            100                 105                 110         
Phe Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125     


<210> 109
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 2-F07 Variable Light (VL) Region

<400> 109
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc 60
tcctgctctg gaagcacctc caacattggg aagaattatg tatcctggta tcagcagctc 120
ccaggaacgg cccccaaact cctcatctat ggtaacagca atcggccctc aggggtccct 180
gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg 240
tccgaggatg aggctgatta ttactgtgca gcatgggatg ccagcctcag tggttgggtg 300
ttcggcggag gaaccaagct gacggtccta ggt                              333

<210> 110
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 2-F07 Variable Light (VL) Region

<400> 110
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Thr Ser Asn Ile Gly Lys Asn
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Ala Ser Leu
                85                  90                  95      
Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110     


<210> 111
<211> 363
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 2-F09 Variable Heavy(VH) Region

<400> 111
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60
tcctgtgcag cctctggatt caccttcagt agttcttgga tgagttgggt ccgccaggct 120
ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtagtta catatactac 180
gcagactcag tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gagagtaggg 300
aactacggtt tctaccacta catggacgtc tggggccaag gtacactggt caccgtgagc 360
tca                                                               363

<210> 112
<211> 121
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 2-F09 Variable Heavy (VH) Region

<400> 112
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Ser
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Val Gly Asn Tyr Gly Phe Tyr His Tyr Met Asp Val Trp Gly
            100                 105                 110         
Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120     


<210> 113
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 2-F09 Variable Light (VL) Region

<400> 113
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc 60
tcttgttctg gaggcagctc aaacatcgga aaaagaggtg taaattggta tcagcagctc 120
ccaggaacgg cccccaaact cctcatctat ggtaacagaa atcggccctc aggggtccct 180
gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg 240
tccgaggatg aggctgatta ttactgtgct acatgggatt acagcctcaa tgcttgggtg 300
ttcggcggag gaaccaagct gacggtccta ggt                              333

<210> 114
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 2-F09 Variable Light (VL) Region

<400> 114
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Gly Ser Ser Asn Ile Gly Lys Arg
            20                  25                  30          
Gly Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Gly Asn Arg Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Thr Trp Asp Tyr Ser Leu
                85                  90                  95      
Asn Ala Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110     


<210> 115
<211> 366
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 4-A02 Variable Heavy (VH) Region

<400> 115
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60
tcctgtgcag cctctggatt cacctttagt agctattgga tgagctgggt ccgccaggct 120
ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtagtta catatactac 180
gcagactcag tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gagaattaaa 300
cggttacgat tcggctggac cccttttgac tactggggcc agggtacact ggtcaccgtg 360
agctca                                                            366

<210> 116
<211> 122
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 4-A02 Variable Heavy (VH) Region

<400> 116
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Tyr
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Ile Lys Arg Leu Arg Phe Gly Trp Thr Pro Phe Asp Tyr Trp
            100                 105                 110         
Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120         


<210> 117
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 4-A02 Variable Light (VL) Region

<400> 117
cagtctgttc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc 60
tcctgttctg gaagcagctc caacatcgga aataatggtg taaactggta tcagcagctc 120
ccaggaacgg cccccaaact cctcatctat ggtaacaaca atcggccctc aggggtccct 180
gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg 240
tccgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgcg tggttggctg 300
ttcggcggag gaaccaagct gacggtccta ggt                              333

<210> 118
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 4-A02 Variable Light (VL) Region

<400> 118
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
            20                  25                  30          
Gly Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Gly Asn Asn Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
                85                  90                  95      
Arg Gly Trp Leu Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110     


<210> 119
<211> 369
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 4-C03 Variable Heavy (VH) Region

<400> 119
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60
tcctgtgcag cctctggatt caccttcagt aacgcctgga tgagctgggt ccgccaggct 120
ccagggaagg ggctggagtg ggtctcatcc attagtagta gtagtagtta catatactac 180
gcagactcag tgaagggccg attcaccatc tccagagaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gagagtcaat 300
agcaaaaagt ggtatgaggg ctacttcttt gactactggg gccagggtac actggtcacc 360
gtgagctca                                                         369

<210> 120
<211> 123
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 4-C03 Variable Heavy (VH) Region

<400> 120
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ser Ile Ser Ser Ser Ser Ser Tyr Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Val Asn Ser Lys Lys Trp Tyr Glu Gly Tyr Phe Phe Asp Tyr
            100                 105                 110         
Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120             


<210> 121
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 4-C03 Variable Light (VL) Region

<400> 121
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc 60
tcctgctctg gaagcagctc caacattggg aataattatg tatcctggta tcagcagctc 120
ccaggaacgg cccccaaact cctcatctat ggtaacagca atcggccctc aggggtccct 180
gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg 240
tccgaggatg aggctgatta ttactgtgca gcatgggatg acagtctgag tggttgggtg 300
ttcggcggag gaaccaagct gacggtccta ggt                              333

<210> 122
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 4-C03 Variable Light (VL) Region

<400> 122
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn
            20                  25                  30          
Tyr Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Gly Asn Ser Asn Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
                85                  90                  95      
Ser Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110     


<210> 123
<211> 375
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 4-D04 Variable Heavy (VH) Region

<400> 123
gaggtgcagc tgttggagtc tgggggaggc ttggtacagc ctggggggtc cctgagactc 60
tcctgtgcag cctctggatt caccttcagt aacgcctgga tgagctgggt ccgccaggct 120
ccagggaagg ggctggagtg ggtctcatcc attagtacta gtagtaatta catatactac 180
gcagactcag tgaagggccg gttcaccatc tccagagaca attccaagaa cacgctgtat 240
ctgcaaatga acagcctgag agccgaggac actgccgtgt attactgtgc gagagtcaag 300
aagtatagca gtggctggta ctcgaattat gcttttgata tctggggcca aggtacactg 360
gtcaccgtga gctca                                                  375

<210> 124
<211> 125
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 4-D04 Variable Heavy (VH) Region

<400> 124
Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly
 1               5                  10                  15      
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Ala
            20                  25                  30          
Trp Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val
        35                  40                  45              
Ser Ser Ile Ser Thr Ser Ser Asn Tyr Ile Tyr Tyr Ala Asp Ser Val
    50                  55                  60                  
Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr
65                  70                  75                  80  
Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys
                85                  90                  95      
Ala Arg Val Lys Lys Tyr Ser Ser Gly Trp Tyr Ser Asn Tyr Ala Phe
            100                 105                 110         
Asp Ile Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser
        115                 120                 125 


<210> 125
<211> 333
<212> DNA
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 4-D04 Variable Light (VL) Region

<400> 125
cagtctgtgc tgactcagcc accctcagcg tctgggaccc ccgggcagag ggtcaccatc 60
tcctgctctg gaagcagctc cagcattggg aataattttg tatcctggta tcagcagctc 120
ccaggaacgg cccccaaact cctcatctat gacaataata agcgaccctc aggggtccct 180
gaccgattct ctggctccaa gtctggcacc tcagcctccc tggccatcag tgggctccgg 240
tccgaggatg aggctgatta ttactgtgca gcatgggatg acagcctgaa tggttgggtg 300
ttcggcggag gaaccaagct gacggtccta ggt                              333

<210> 126
<211> 111
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<220>
<223> 4-D04 Variable Light (VL) Region

<400> 126
Gln Ser Val Leu Thr Gln Pro Pro Ser Ala Ser Gly Thr Pro Gly Gln
 1               5                  10                  15      
Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Ser Ile Gly Asn Asn
            20                  25                  30          
Phe Val Ser Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu
        35                  40                  45              
Ile Tyr Asp Asn Asn Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser
    50                  55                  60                  
Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Ser Gly Leu Arg
65                  70                  75                  80  
Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Ala Trp Asp Asp Ser Leu
                85                  90                  95      
Asn Gly Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly
            100                 105                 110     


<210> 127
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 127
Cys Ser Gly Ser Ser Ser Asn Ile Gly Asn Asn Tyr Val Ser
 1               5                  10                  


<210> 128
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 128
Ser Asn Asn Gln Arg Pro Ser
 1               5          


<210> 129
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 129
Cys Ala Ala Trp Asp Asp Ser Leu Ser His Trp Leu
 1               5                  10          


<210> 130
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 130
Phe Ser Asn Ala Trp Met Ser Trp Val Arg Gln Val Pro Gly
 1               5                  10                  


<210> 131
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 131
Ser Thr Leu Gly Gly Ser Gly Gly Gly Ser Thr Tyr Tyr Ala Asp Ser
 1               5                  10                  15      
Val Lys Gly Arg
            20  


<210> 132
<211> 18
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 132
Ala Lys Leu Gly Gly Arg Ser Arg Tyr Gly Arg Trp Pro Arg Gln Phe
 1               5                  10                  15      
Asp Tyr
        


<210> 133
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 133
Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Ser
 1               5                  10                  


<210> 134
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 134
Gly Asn Tyr Asn Arg Pro Ser
 1               5          


<210> 135
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 135
Cys Ala Ala Trp Asp Asp Ser Leu Ser Gly Trp Val
 1               5                  10          


<210> 136
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 136
Phe Ser Ser Tyr Trp Met Ser Trp Val Arg Gln Ala Pro Gly
 1               5                  10                  


<210> 137
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 137
Ser Ser Ile Ser Gly Ser Gly Arg Arg Thr Tyr Tyr Ala Asp Ser Val
 1               5                  10                  15      
Gln Gly Arg
            


<210> 138
<211> 15
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 138
Ala Arg Leu Val Ser Tyr Gly Ser Gly Ser Phe Gly Phe Asp Tyr
 1               5                  10                  15  


<210> 139
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 139
Cys Ser Gly Arg Ser Ser Asn Ile Gly Asn Ser Tyr Val Ser
 1               5                  10                  


<210> 140
<211> 7
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 140
Arg Asn Asn Gln Arg Pro Ser
 1               5          


<210> 141
<211> 12
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 141
Cys Ala Gly Trp Asp Asp Thr Leu Arg Ala Trp Val
 1               5                  10          


<210> 142
<211> 14
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 142
Phe Arg Asp Tyr Tyr Val Ser Trp Ile Arg Gln Ala Pro Gly
 1               5                  10                  


<210> 143
<211> 19
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 143
Ser Ser Ile Ser Gly Ser Gly Gly Arg Thr Tyr Tyr Ala Asp Ser Val
 1               5                  10                  15      
Glu Gly Arg
            


<210> 144
<211> 20
<212> PRT
<213> Artificial Sequence

<220> 
<223> Synthetic construct

<400> 144
Ala Arg Val Ser Ala Leu Arg Arg Pro Met Thr Thr Val Thr Thr Tyr
 1               5                  10                  15      
Trp Phe Asp Pro
            20  

