                         SEQUENCE LISTING

<110>  VLST CORPORATION
       Allison, Dan
       Raport, Carol
 
<120>  Multikine Antibodies that Bind to Multiple CC Chemokines

<130>  366369WO

<150>  US 61/238,015
<151>  2009-08-28

<160>  117   

<170>  PatentIn version 3.5

<210>  1
<211>  357
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(357)
<223>  Coding sequence for 3C12F VH

<400>  1
gag gtt cag ctg cag cag tct ggg gca gag ctt gtg aag cca ggg gcc         48
Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala           
1               5                   10                  15                

tca gtc aag ttg tcc tgc aca gct tct ggc ttc aac att aaa gac acc         96
Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr           
            20                  25                  30                    

tat ata cac tgg gtg aag cag agg cct gaa cag ggc ctg gag tgg att        144
Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile           
        35                  40                  45                        

gga agg att gat cct gcg aat ggt aat act caa tat gac ccg aag ttc        192
Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Gln Tyr Asp Pro Lys Phe           
    50                  55                  60                            

cag ggc aag gcc act ata aca gca gac aca tcc tcc aac aca gcc tac        240
Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr           
65                  70                  75                  80            

ctg cag ctc acc agc ctg aca tct gag gac act gcc gtc tat tac tgt        288
Leu Gln Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys           
                85                  90                  95                

gct aga agg tgg gat tac gac tat gct atg gac tac tgg ggt caa gga        336
Ala Arg Arg Trp Asp Tyr Asp Tyr Ala Met Asp Tyr Trp Gly Gln Gly           
            100                 105                 110                   

acc tca gtc acc gtc tcc tca                                            357
Thr Ser Val Thr Val Ser Ser                                               
        115                                                               


<210>  2
<211>  119
<212>  PRT
<213>  Mus musculus

<400>  2

Glu Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Thr Ala Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Lys Gln Arg Pro Glu Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Gln Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Thr Ala Asp Thr Ser Ser Asn Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Leu Thr Ser Leu Thr Ser Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Trp Asp Tyr Asp Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Ser Val Thr Val Ser Ser 
        115                 


<210>  3
<211>  5
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  VH CDR1 of 3C12F

<400>  3

Asp Thr Tyr Ile His 
1               5   


<210>  4
<211>  17
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  VH CDR2 of 3C12F

<400>  4

Arg Ile Asp Pro Ala Asn Gly Asn Thr Gln Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  5
<211>  10
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  VH CDR3 of 3C12F

<400>  5

Arg Trp Asp Tyr Asp Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  6
<211>  321
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(321)
<223>  Coding sequence for 3C12F VL

<400>  6
gac atc cag atg act cag tct cca gcc tcc cta tct gca tct gtg gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gaa act gtc acc atc aca tgt cga gga agt ggg aat att cac aat tat         96
Glu Thr Val Thr Ile Thr Cys Arg Gly Ser Gly Asn Ile His Asn Tyr           
            20                  25                  30                    

tta gca tgg tat cag cag aaa cag gga aaa tct cct cag ctc ctg gtc        144
Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val           
        35                  40                  45                        

tat aat gca aaa acc tta gca gat ggt gtg cca tca agg ttc agt ggc        192
Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tca gga aca caa tat tct ctc aag atc aac agc ctg cag cct        240
Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro           
65                  70                  75                  80            

gaa gat ttt ggg agt tat tac tgt caa cat ttt tgg agt act ccg tac        288
Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Tyr           
                85                  90                  95                

acg ttc gga ggg ggg acc aag ctg gaa ata aaa                            321
Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys                               
            100                 105                                       


<210>  7
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  7

Asp Ile Gln Met Thr Gln Ser Pro Ala Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Glu Thr Val Thr Ile Thr Cys Arg Gly Ser Gly Asn Ile His Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Gln Gly Lys Ser Pro Gln Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Gln Tyr Ser Leu Lys Ile Asn Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Gly Ser Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  8
<211>  11
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  VL CDR1 of 3C12F

<400>  8

Arg Gly Ser Gly Asn Ile His Asn Tyr Leu Ala 
1               5                   10      


<210>  9
<211>  7
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  VL CDR2 of 3C12F

<400>  9

Asn Ala Lys Thr Leu Ala Asp 
1               5           


<210>  10
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  VL CDR3 of 3C12F

<400>  10

Gln His Phe Trp Ser Thr Pro Tyr Thr 
1               5                   


<210>  11
<211>  354
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(354)
<223>  Coding sequence for 7D12A VH

<400>  11
gag gtg cat ctt cag gag tca gga cct agc ctc gtg aaa cct tct cag         48
Glu Val His Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln           
1               5                   10                  15                

act ctg tcc ctc acc tgt tct gtc act ggc gac tcc atc acc aat ggt         96
Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Asn Gly           
            20                  25                  30                    

tac tgg aac tgg atc cgg aaa ttc cca ggg aat aaa ctt gac tac atg        144
Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Asp Tyr Met           
        35                  40                  45                        

gga tac ata agc tac gat ggt aac act tac tac aat cca tct ctc aaa        192
Gly Tyr Ile Ser Tyr Asp Gly Asn Thr Tyr Tyr Asn Pro Ser Leu Lys           
    50                  55                  60                            

agt cga ttc tcc atc act cga gac aca tcc aag aac cag tac tac ctg        240
Ser Arg Phe Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu           
65                  70                  75                  80            

cag ttg aat tct gtg act act gaa gac aca gcc aca tat tac tgt tca        288
Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ser           
                85                  90                  95                

aga gga gac tac gga acc tat gtt atg gac tac tgg ggt caa gga acc        336
Arg Gly Asp Tyr Gly Thr Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr           
            100                 105                 110                   

tca gtc acc gtc tcc tca                                                354
Ser Val Thr Val Ser Ser                                                   
        115                                                               


<210>  12
<211>  118
<212>  PRT
<213>  Mus musculus

<400>  12

Glu Val His Leu Gln Glu Ser Gly Pro Ser Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Thr Leu Ser Leu Thr Cys Ser Val Thr Gly Asp Ser Ile Thr Asn Gly 
            20                  25                  30          


Tyr Trp Asn Trp Ile Arg Lys Phe Pro Gly Asn Lys Leu Asp Tyr Met 
        35                  40                  45              


Gly Tyr Ile Ser Tyr Asp Gly Asn Thr Tyr Tyr Asn Pro Ser Leu Lys 
    50                  55                  60                  


Ser Arg Phe Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Tyr Tyr Leu 
65                  70                  75                  80  


Gln Leu Asn Ser Val Thr Thr Glu Asp Thr Ala Thr Tyr Tyr Cys Ser 
                85                  90                  95      


Arg Gly Asp Tyr Gly Thr Tyr Val Met Asp Tyr Trp Gly Gln Gly Thr 
            100                 105                 110         


Ser Val Thr Val Ser Ser 
        115             


<210>  13
<211>  5
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  VH CDR1 of 7D12A

<400>  13

Asn Gly Tyr Trp Asn 
1               5   


<210>  14
<211>  16
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(16)
<223>  VH CDR2 of 7D12A

<400>  14

Tyr Ile Ser Tyr Asp Gly Asn Thr Tyr Tyr Asn Pro Ser Leu Lys Ser 
1               5                   10                  15      


<210>  15
<211>  10
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(10)
<223>  VH CDR3 of 7D12A

<400>  15

Gly Asp Tyr Gly Thr Tyr Val Met Asp Tyr 
1               5                   10  


<210>  16
<211>  333
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(333)
<223>  Coding sequence for 7D12A VL

<400>  16
aac att gtg ctg acc caa tct cca gtt tct ttg gct gtg tct cta ggg         48
Asn Ile Val Leu Thr Gln Ser Pro Val Ser Leu Ala Val Ser Leu Gly           
1               5                   10                  15                

cag agg gcc acc att tcc tgc aga gcc agt gaa agt gtt gat agt cat         96
Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser His           
            20                  25                  30                    

ggc aat agt ttt atg cac tgg tac cag cag aaa ccg gga cag cca ccc        144
Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro           
        35                  40                  45                        

aaa ctc ctc atc tat ctt gca tcc aac cta gag tct ggg gtc cct gcc        192
Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala           
    50                  55                  60                            

agg ttc act ggc ggt ggg tct ggg tca gac ttc acc ctg acc att gac        240
Arg Phe Thr Gly Gly Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile Asp           
65                  70                  75                  80            

cct gtg gag gct gat gat gtt gga aca tat tac tgt cag caa aat aat        288
Pro Val Glu Ala Asp Asp Val Gly Thr Tyr Tyr Cys Gln Gln Asn Asn           
                85                  90                  95                

gag gat ccg tac acg ttc gga ggg ggg acc aag ctg gaa ata aaa            333
Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys               
            100                 105                 110                   


<210>  17
<211>  111
<212>  PRT
<213>  Mus musculus

<400>  17

Asn Ile Val Leu Thr Gln Ser Pro Val Ser Leu Ala Val Ser Leu Gly 
1               5                   10                  15      


Gln Arg Ala Thr Ile Ser Cys Arg Ala Ser Glu Ser Val Asp Ser His 
            20                  25                  30          


Gly Asn Ser Phe Met His Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 
        35                  40                  45              


Lys Leu Leu Ile Tyr Leu Ala Ser Asn Leu Glu Ser Gly Val Pro Ala 
    50                  55                  60                  


Arg Phe Thr Gly Gly Gly Ser Gly Ser Asp Phe Thr Leu Thr Ile Asp 
65                  70                  75                  80  


Pro Val Glu Ala Asp Asp Val Gly Thr Tyr Tyr Cys Gln Gln Asn Asn 
                85                  90                  95      


Glu Asp Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110     


<210>  18
<211>  15
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(15)
<223>  VL CDR1 of 7D12A

<400>  18

Arg Ala Ser Glu Ser Val Asp Ser His Gly Asn Ser Phe Met His 
1               5                   10                  15  


<210>  19
<211>  7
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  VL CDR2 of 7D12A

<400>  19

Leu Ala Ser Asn Leu Glu Ser 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  VL CDR3 of 7D12A

<400>  20

Gln Gln Asn Asn Glu Asp Pro Tyr Thr 
1               5                   


<210>  21
<211>  345
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(345)
<223>  Coding sequence for 7D1G VH

<400>  21
cag gtg cag ctg cag cag cct ggg gct gag ctg gtg aag cct ggg gcc         48
Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala           
1               5                   10                  15                

tca gtg aag atg tcc tgc aag gct tct ggc tac aca ttt acc agt tac         96
Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr           
            20                  25                  30                    

aat ata cac tgg gta aag cag aca cct gga cag ggc ctg gaa tgg att        144
Asn Ile His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile           
        35                  40                  45                        

gga gct gtt tct cca cga aat ggt gat act tcc tac aat cag agg ttc        192
Gly Ala Val Ser Pro Arg Asn Gly Asp Thr Ser Tyr Asn Gln Arg Phe           
    50                  55                  60                            

aaa ggc aag gcc aca ttg act gca gac att tcc tcc agc aca gcc tac        240
Lys Gly Lys Ala Thr Leu Thr Ala Asp Ile Ser Ser Ser Thr Ala Tyr           
65                  70                  75                  80            

atg cag ctc agc agc ctg aca tct gag gac tct gcg gtc tat tac tgt        288
Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys           
                85                  90                  95                

gca aga ggg tat ggt tac gac tac tgg ggc caa ggc acc act ctc aca        336
Ala Arg Gly Tyr Gly Tyr Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr           
            100                 105                 110                   

gtc tcc tca                                                            345
Val Ser Ser                                                               
        115                                                               


<210>  22
<211>  115
<212>  PRT
<213>  Mus musculus

<400>  22

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Asn Ile His Trp Val Lys Gln Thr Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Ala Val Ser Pro Arg Asn Gly Asp Thr Ser Tyr Asn Gln Arg Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ala Asp Ile Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Gly Tyr Gly Tyr Asp Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  23
<211>  5
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(5)
<223>  VH CDR1 of 7D1G

<400>  23

Ser Tyr Asn Ile His 
1               5   


<210>  24
<211>  17
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(17)
<223>  VH CDR2 of 7D1G

<400>  24

Ala Val Ser Pro Arg Asn Gly Asp Thr Ser Tyr Asn Gln Arg Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  25
<211>  6
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  VH CDR3 of 7D1G

<400>  25

Gly Tyr Gly Tyr Asp Tyr 
1               5       


<210>  26
<211>  321
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(321)
<223>  Coding sequence for 7D1G VL

<400>  26
gat gtt gtg cta act cag tct cca gcc acc ctg tct gtg act cca gga         48
Asp Val Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly           
1               5                   10                  15                

gat aga gtc agt ctt tcc tgc agg gcc agt caa agt gtt agc aag tac         96
Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Lys Tyr           
            20                  25                  30                    

cta cac tgg tat caa caa aaa tca cat gag tct cca agg ctt ctc atc        144
Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile           
        35                  40                  45                        

aag tat gtt tcc cag tcc atc tct ggg atc ccc tcc agg ttc agt ggc        192
Lys Tyr Val Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tca ggg aca gat ttc act ctc agt atc aac agt gtg gag act        240
Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr           
65                  70                  75                  80            

gaa gat ttg gga atg tat ttc tgt caa cag agt aac agc tgg cct cac        288
Glu Asp Leu Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro His           
                85                  90                  95                

acg ttc ggt gct ggg acc aag ctg gag ctg aaa                            321
Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys                               
            100                 105                                       


<210>  27
<211>  107
<212>  PRT
<213>  Mus musculus

<400>  27

Asp Val Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Lys Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Val Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Ser Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Leu Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro His 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105         


<210>  28
<211>  11
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  VL CDR1 of 7D1G

<400>  28

Arg Ala Ser Gln Ser Val Ser Lys Tyr Leu His 
1               5                   10      


<210>  29
<211>  7
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  VL CDR2 of 7D1G

<400>  29

Tyr Val Ser Gln Ser Ile Ser 
1               5           


<210>  30
<211>  9
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(9)
<223>  VL CDR3 of 7D1G

<400>  30

Gln Gln Ser Asn Ser Trp Pro His Thr 
1               5                   


<210>  31
<211>  360
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(360)
<223>  Coding sequence for MAb 18V4F VH

<400>  31
cag gtg cag ctg aag gag tca gga cct ggc ctg gtg gcg ccc tca cag         48
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln           
1               5                   10                  15                

agc ctg tcc atc act tgc act gtc tct ggg ttt tca tta acc ggc tat         96
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr           
            20                  25                  30                    

ggt ata cac tgg gtt cgc cag cct cca gga aag ggt ctg gag tgg ctg        144
Gly Ile His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu           
        35                  40                  45                        

gga gta ata tgg cct ggt gga ggc aca aat tat aat tcg gct ctc atg        192
Gly Val Ile Trp Pro Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Met           
    50                  55                  60                            

tcc aga ctg agc atc agc aaa gac aac tcc aag agc caa gtt ttc tta        240
Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu           
65                  70                  75                  80            

aaa atg aac agt ctg caa act gat gac aca gcc atg tac tac tgt gcc        288
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala           
                85                  90                  95                

aga ggt ccc ctt att act acg gaa gtt tct atg gac tac tgg ggt caa        336
Arg Gly Pro Leu Ile Thr Thr Glu Val Ser Met Asp Tyr Trp Gly Gln           
            100                 105                 110                   

gga acc tcg gtc acc gtc tcc tca                                        360
Gly Thr Ser Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  32
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  32

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Pro Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Ser Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Pro Leu Ile Thr Thr Glu Val Ser Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  33
<211>  7
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  MAb 18V4F VH CDR1

<400>  33

Gly Phe Ser Leu Thr Gly Tyr 
1               5           


<210>  34
<211>  14
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  MAb 18V4F VH CDR 2

<400>  34

Trp Pro Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  


<210>  35
<211>  12
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  MAb 18V4F VH CDR 3

<400>  35

Gly Pro Leu Ile Thr Thr Glu Val Ser Met Asp Tyr 
1               5                   10          


<210>  36
<211>  330
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(330)

<220>
<221>  misc_feature
<222>  (1)..(330)
<223>  Coding sequence for 18V4F VL

<400>  36
cag gct gtt gtg act cag gaa tct gca ctc acc aca tca cct ggt gaa         48
Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu           
1               5                   10                  15                

aca gtc aca ctc act tgt cgc tca aat act ggg gct gtt aca act agt         96
Thr Val Thr Leu Thr Cys Arg Ser Asn Thr Gly Ala Val Thr Thr Ser           
            20                  25                  30                    

aac tat gcc aac tgg gtc caa gaa aaa cca gat cat tta ttc act ggt        144
Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly           
        35                  40                  45                        

cta ata ggt ggt acc aac aac cga gct cca ggt gtt cct gcc aga ttc        192
Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe           
    50                  55                  60                            

tca ggc tcc ctg att gga gac aag gct gcc ctc acc atc aca ggg gca        240
Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala           
65                  70                  75                  80            

cag act gag gat gag gca ata tat ttc tgt gct cta tgg tac agc aac        288
Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn           
                85                  90                  95                

cat tgg gtg ttc ggt gga gga acc aaa ctg act gtc cta ggc                330
His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly                   
            100                 105                 110                   


<210>  37
<211>  110
<212>  PRT
<213>  Mus musculus

<400>  37

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Asn Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 


<210>  38
<211>  11
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  MAb 18V4F VL CDR 1

<400>  38

Ser Asn Thr Gly Ala Val Thr Thr Ser Asn Tyr 
1               5                   10      


<210>  39
<211>  3
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  MAb 18V4F VL CDR 2

<220>
<221>  MISC_FEATURE

<400>  39

Gly Thr Asn 
1                  


<210>  40
<211>  6
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  MAb 18V4F VL CDR3

<400>  40

Trp Tyr Ser Asn His Trp 
1               5       


<210>  41
<211>  360
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(360)
<223>  MAb 18P7E VH coding region

<400>  41
cag gtg cag ctg aag gag tca gga cct ggc ctg gtg gcg ccc tca cag         48
Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln           
1               5                   10                  15                

agc ctg tcc atc act tgc act gtc tct ggg ttt tca tta acc ggc tat         96
Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr           
            20                  25                  30                    

ggt ata cac tgg gtt cgc cag cct cca gga aag ggt ctg gag tgg ctg        144
Gly Ile His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu           
        35                  40                  45                        

gga gta ata tgg cct ggt gga ggc aca aat tat aat tcg gct ctc atg        192
Gly Val Ile Trp Pro Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Met           
    50                  55                  60                            

tcc aga ctg aac atc agc aaa gac aac tcc aag agc caa gtt ttc tta        240
Ser Arg Leu Asn Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu           
65                  70                  75                  80            

aaa atg aac agt ctg caa act gat gac aca gcc atg tac tac tgt gcc        288
Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala           
                85                  90                  95                

aga ggt ccc ctt att act acg gaa gtt tct atg gac tac tgg ggt caa        336
Arg Gly Pro Leu Ile Thr Thr Glu Val Ser Met Asp Tyr Trp Gly Gln           
            100                 105                 110                   

gga acc tcg gtc acc gtc tcc tca                                        360
Gly Thr Ser Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  42
<211>  120
<212>  PRT
<213>  Mus musculus

<400>  42

Gln Val Gln Leu Lys Glu Ser Gly Pro Gly Leu Val Ala Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Ile Thr Cys Thr Val Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          


Gly Ile His Trp Val Arg Gln Pro Pro Gly Lys Gly Leu Glu Trp Leu 
        35                  40                  45              


Gly Val Ile Trp Pro Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Leu Asn Ile Ser Lys Asp Asn Ser Lys Ser Gln Val Phe Leu 
65                  70                  75                  80  


Lys Met Asn Ser Leu Gln Thr Asp Asp Thr Ala Met Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Pro Leu Ile Thr Thr Glu Val Ser Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Ser Val Thr Val Ser Ser 
        115                 120 


<210>  43
<211>  7
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(7)
<223>  MAb 18P7E VH CDR1

<400>  43

Gly Phe Ser Leu Thr Gly Tyr 
1               5           


<210>  44
<211>  14
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(14)
<223>  MAb 18P7E VH CDR2

<400>  44

Trp Pro Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  


<210>  45
<211>  12
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(12)
<223>  MAb 18P7E VH CDR3

<400>  45

Gly Pro Leu Ile Thr Thr Glu Val Ser Met Asp Tyr 
1               5                   10          


<210>  46
<211>  330
<212>  DNA
<213>  Mus musculus


<220>
<221>  CDS
<222>  (1)..(330)
<223>  MAb 18P7E VL coding sequence

<400>  46
cag gct gtt gtg act cag gaa tct gca ctc acc aca tca cct ggt gaa         48
Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu           
1               5                   10                  15                

aca gtc aca ctc act tgt cgc tca aat act ggg gct gtt aca act agt         96
Thr Val Thr Leu Thr Cys Arg Ser Asn Thr Gly Ala Val Thr Thr Ser           
            20                  25                  30                    

aac tat gcc aac tgg gtc caa gaa aaa cca gat cat tta ttc act ggt        144
Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly           
        35                  40                  45                        

cta ata ggt ggt acc aac aac cga gct cca ggt gtt cct gcc aga ttc        192
Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe           
    50                  55                  60                            

tca ggc tcc ctg att gga gac aag gct gcc ctc acc atc aca ggg gca        240
Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala           
65                  70                  75                  80            

cag act gag gat gag gca ata tat ttc tgt gct cta tgg tac agc aac        288
Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn           
                85                  90                  95                

cat tgg gtg ttc ggt gga gga acc aaa ctg act gtc cta ggc                330
His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly                   
            100                 105                 110                   


<210>  47
<211>  110
<212>  PRT
<213>  Mus musculus

<400>  47

Gln Ala Val Val Thr Gln Glu Ser Ala Leu Thr Thr Ser Pro Gly Glu 
1               5                   10                  15      


Thr Val Thr Leu Thr Cys Arg Ser Asn Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Glu Lys Pro Asp His Leu Phe Thr Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Asn Arg Ala Pro Gly Val Pro Ala Arg Phe 
    50                  55                  60                  


Ser Gly Ser Leu Ile Gly Asp Lys Ala Ala Leu Thr Ile Thr Gly Ala 
65                  70                  75                  80  


Gln Thr Glu Asp Glu Ala Ile Tyr Phe Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 


<210>  48
<211>  11
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(11)
<223>  MAb 18P7E VL CDR1

<400>  48

Ser Asn Thr Gly Ala Val Thr Thr Ser Asn Tyr 
1               5                   10      


<210>  49
<211>  3
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(3)
<223>  MAb 18P7E VL CDR2

<220>

<400>  49

Gly Thr Asn 
1                 


<210>  50
<211>  6
<212>  PRT
<213>  Mus musculus


<220>
<221>  MISC_FEATURE
<222>  (1)..(6)
<223>  MAb 18P7E VL CDR3

<400>  50

Trp Tyr Ser Asn His Trp 
1               5       


<210>  51
<211>  357
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized version of MAb 3C12F


<220>
<221>  CDS
<222>  (1)..(357)
<223>  Humanized MAb 3C12F VH coding sequence

<400>  51
gag gtg cag ctg gtg cag tct gga gca gag gtg aaa aag ccc ggg gag         48
Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu           
1               5                   10                  15                

tct ctg aag atc tcc tgt aag ggt tct gga ttc aac att aaa gac acc         96
Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Phe Asn Ile Lys Asp Thr           
            20                  25                  30                    

tat ata cac tgg gtg cgc cag atg ccc ggg aaa ggc ctg gag tgg att        144
Tyr Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile           
        35                  40                  45                        

ggg agg att gat cct gcg aat ggt aat act caa tat gac ccg aag ttc        192
Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Gln Tyr Asp Pro Lys Phe           
    50                  55                  60                            

cag ggc aag gcc acc atc tca gcc gac aca tcc atc agc acc gcc tac        240
Gln Gly Lys Ala Thr Ile Ser Ala Asp Thr Ser Ile Ser Thr Ala Tyr           
65                  70                  75                  80            

ctg cag tgg agc agc ctg aag gcc tcg gac acc gcc atg tat tac tgt        288
Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys           
                85                  90                  95                

gcg aga agg tgg gat tac gac tat gct atg gac tac tgg ggg caa ggg        336
Ala Arg Arg Trp Asp Tyr Asp Tyr Ala Met Asp Tyr Trp Gly Gln Gly           
            100                 105                 110                   

acc acg gtc acc gtc tcc tca                                            357
Thr Thr Val Thr Val Ser Ser                                               
        115                                                               


<210>  52
<211>  119
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  52

Glu Val Gln Leu Val Gln Ser Gly Ala Glu Val Lys Lys Pro Gly Glu 
1               5                   10                  15      


Ser Leu Lys Ile Ser Cys Lys Gly Ser Gly Phe Asn Ile Lys Asp Thr 
            20                  25                  30          


Tyr Ile His Trp Val Arg Gln Met Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Arg Ile Asp Pro Ala Asn Gly Asn Thr Gln Tyr Asp Pro Lys Phe 
    50                  55                  60                  


Gln Gly Lys Ala Thr Ile Ser Ala Asp Thr Ser Ile Ser Thr Ala Tyr 
65                  70                  75                  80  


Leu Gln Trp Ser Ser Leu Lys Ala Ser Asp Thr Ala Met Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Trp Asp Tyr Asp Tyr Ala Met Asp Tyr Trp Gly Gln Gly 
            100                 105                 110         


Thr Thr Val Thr Val Ser Ser 
        115                 


<210>  53
<211>  5
<212>  PRT
<213>  artificial sequence

<220>
<223>  Humanized MAb 3C12F VH CDR1

<400>  53

Asp Thr Tyr Ile His
1               5                   



<210>  54
<211>  17
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized MAb 3C12F VH CDR2

<400>  54

Arg Ile Asp Pro Ala Asn Gly Asn Thr Gln Tyr Asp Pro Lys Phe Gln 
1               5                   10                  15      


Gly 
    


<210>  55
<211>  10
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized MAb 3C12F VH CDR3

<400>  55

Arg Trp Asp Tyr Asp Tyr Ala Met Asp Tyr 
1               5                   10  


<210>  56
<211>  321
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized MAb 3C12F VL coding sequence


<220>
<221>  CDS
<222>  (1)..(321)

<400>  56
gac atc cag atg acc cag tct cca tcc tcc ctg tct gca tct gta gga         48
Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly           
1               5                   10                  15                

gac aga gtc acc atc act tgc cga gga agt ggg aat att cac aat tat         96
Asp Arg Val Thr Ile Thr Cys Arg Gly Ser Gly Asn Ile His Asn Tyr           
            20                  25                  30                    

tta gca tgg tat cag cag aaa cca ggg aaa gcc cct aag ctc ctg gtc        144
Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Val           
        35                  40                  45                        

tat aat gca aaa acc tta gca gat ggg gtc cca tca agg ttc agt ggc        192
Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly           
    50                  55                  60                            

agt gga tct ggg aca gat tac act ctc acc atc agc agt ctg caa cct        240
Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro           
65                  70                  75                  80            

gaa gat ttt gca act tac tac tgt caa cat ttt tgg agt act ccg tac        288
Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Tyr           
                85                  90                  95                

acg ttc ggc gga ggg acc aag gtg gag atc aaa                            321
Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys                               
            100                 105                                       


<210>  57
<211>  107
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  57

Asp Ile Gln Met Thr Gln Ser Pro Ser Ser Leu Ser Ala Ser Val Gly 
1               5                   10                  15      


Asp Arg Val Thr Ile Thr Cys Arg Gly Ser Gly Asn Ile His Asn Tyr 
            20                  25                  30          


Leu Ala Trp Tyr Gln Gln Lys Pro Gly Lys Ala Pro Lys Leu Leu Val 
        35                  40                  45              


Tyr Asn Ala Lys Thr Leu Ala Asp Gly Val Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Tyr Thr Leu Thr Ile Ser Ser Leu Gln Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Thr Tyr Tyr Cys Gln His Phe Trp Ser Thr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gly Gly Thr Lys Val Glu Ile Lys 
            100                 105         


<210>  58
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized MAb 3C12F VL CDR1

<400>  58

Arg Gly Ser Gly Asn Ile His Asn Tyr Leu Ala 
1               5                   10      


<210>  59
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized MAb 3C12F VL CDR2

<400>  59

Asn Ala Lys Thr Leu Ala Asp 
1               5           


<210>  60
<211>  9
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized MAb 3C12F VL CDR3

<400>  60

Gln His Phe Trp Ser Thr Pro Tyr Thr 
1               5                   


<210>  61
<211>  360
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized MAb 18V4F VH coding sequence


<220>
<221>  CDS
<222>  (1)..(360)

<400>  61
gaa gtt cag ctg gtg gaa tct ggt ggt ggt ctg gtt caa cct ggc ggc         48
Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly           
1               5                   10                  15                

tct ctg cgt ctg tcc tgc gct gcc tcc ggt ttc tct ctg acc ggc tac         96
Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Gly Tyr           
            20                  25                  30                    

gca atg cac tgg gtt cgc cag gcc ccg ggt aaa ggc ctg gaa tgg gtt        144
Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val           
        35                  40                  45                        

ggt gtt atc tgg ccg ggt ggc ggt act aat tac aac tcc gcg ctg atg        192
Gly Val Ile Trp Pro Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Met           
    50                  55                  60                            

agc cgt ttt acc atc tcc aag gac aat tcc aaa aac acc gtt tac ctg        240
Ser Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu           
65                  70                  75                  80            

cag atg aac tcc ctg cgt gct gaa gat act gct gtg tac tac tgt gct        288
Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala           
                85                  90                  95                

cgt ggt cca ctg atc acc acc gaa gtg agc atg gac tat tgg ggc caa        336
Arg Gly Pro Leu Ile Thr Thr Glu Val Ser Met Asp Tyr Trp Gly Gln           
            100                 105                 110                   

ggt acg ctg gtc acc gtt agc tct                                        360
Gly Thr Leu Val Thr Val Ser Ser                                           
        115                 120                                           


<210>  62
<211>  120
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  62

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Ser Leu Thr Gly Tyr 
            20                  25                  30          


Ala Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Gly Val Ile Trp Pro Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Met 
    50                  55                  60                  


Ser Arg Phe Thr Ile Ser Lys Asp Asn Ser Lys Asn Thr Val Tyr Leu 
65                  70                  75                  80  


Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 
                85                  90                  95      


Arg Gly Pro Leu Ile Thr Thr Glu Val Ser Met Asp Tyr Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  63
<211>  7
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized MAb 18V4F VH CDR1

<400>  63

Gly Phe Ser Leu Thr Gly Tyr 
1               5           


<210>  64
<211>  14
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized MAb 18V4F VH CDR2

<400>  64

Trp Pro Gly Gly Gly Thr Asn Tyr Asn Ser Ala Leu Met Ser 
1               5                   10                  


<210>  65
<211>  12
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized MAb 18V4F VH CDR3

<400>  65

Gly Pro Leu Ile Thr Thr Glu Val Ser Met Asp Tyr 
1               5                   10          


<210>  66
<211>  330
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Humanized MAb 18V4F VL coding sequence


<220>
<221>  CDS
<222>  (1)..(330)
<223>  Humanized MAb 18V4F VL coding sequence

<400>  66
tct gcg gaa gtt acc cag cct ccg tct gtg agc gta tct ccg ggt cag         48
Ser Ala Glu Val Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln           
1               5                   10                  15                

acc gcg cgc atc acg tgt tcc tct aac acg ggc gca gtt acg act agc         96
Thr Ala Arg Ile Thr Cys Ser Ser Asn Thr Gly Ala Val Thr Thr Ser           
            20                  25                  30                    

aac tat gct aac tgg gtt caa cag aag ccg ggc cag gct ccg gtg ggt        144
Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Val Gly           
        35                  40                  45                        

ctg att ggt ggc acg aac gag cgt ccg agc ggc att cca gaa cgt ttt        192
Leu Ile Gly Gly Thr Asn Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe           
    50                  55                  60                            

tct ggc agc tct tct ggt aac act gcg acc ctg acc atc tct ggc gct        240
Ser Gly Ser Ser Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Ala           
65                  70                  75                  80            

cag gct gaa gac gaa gcg gat tac tac tgc gcg ctg tgg tac agc aac        288
Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn           
                85                  90                  95                

cac tgg gta ttc ggc ggt ggt acc aaa ctg act gtg ctg ggc                330
His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly                   
            100                 105                 110                   


<210>  67
<211>  110
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Synthetic Construct

<400>  67

Ser Ala Glu Val Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Thr Cys Ser Ser Asn Thr Gly Ala Val Thr Thr Ser 
            20                  25                  30          


Asn Tyr Ala Asn Trp Val Gln Gln Lys Pro Gly Gln Ala Pro Val Gly 
        35                  40                  45              


Leu Ile Gly Gly Thr Asn Glu Arg Pro Ser Gly Ile Pro Glu Arg Phe 
    50                  55                  60                  


Ser Gly Ser Ser Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Ala 
65                  70                  75                  80  


Gln Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Ala Leu Trp Tyr Ser Asn 
                85                  90                  95      


His Trp Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly 
            100                 105                 110 


<210>  68
<211>  11
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized MAb 18V4F VL CDR1

<400>  68

Ser Asn Thr Gly Ala Val Thr Thr Ser Asn Tyr 
1               5                   10      


<210>  69
<211>  3
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized MAb 18V4F VL CDR2


<400>  69

Gly Thr Asn 
1                 


<210>  70
<211>  8
<212>  PRT
<213>  Artificial Sequence

<220>
<223>  Humanized MAb 18V4F VL CDR3

<400>  70

Ala Leu Trp Tyr Ser Asn His Trp 
1               5               


<210>  71
<211>  70
<212>  PRT
<213>  Homo sapiens

<220>
<221>  MISC_FEATURE
<222>  (1)..(70)
<223>  Human MIP1-alpha, CCL3

<400>  71

Ala Ser Leu Ala Ala Asp Thr Pro Thr Ala Cys Cys Phe Ser Tyr Thr 
1               5                   10                  15      


Ser Arg Gln Ile Pro Gln Asn Phe Ile Ala Asp Tyr Phe Glu Thr Ser 
            20                  25                  30          


Ser Gln Cys Ser Lys Pro Gly Val Ile Phe Leu Thr Lys Arg Ser Arg 
        35                  40                  45              


Gln Val Cys Ala Asp Pro Ser Glu Glu Trp Val Gln Lys Tyr Val Ser 
    50                  55                  60                  


Asp Leu Glu Leu Ser Ala 
65                  70  


<210>  72
<211>  69
<212>  PRT
<213>  Homo sapiens

<220>
<221>  MISC_FEATURE
<222>  (1)..(69)
<223>  Human MIP1-beta, CCL4

<400>  72

Ala Pro Met Gly Ser Asp Pro Pro Thr Ala Cys Cys Phe Ser Tyr Thr 
1               5                   10                  15      


Ala Arg Lys Leu Pro His Asn Phe Val Val Asp Tyr Tyr Glu Thr Ser 
            20                  25                  30          


Ser Leu Cys Ser Gln Pro Ala Val Val Phe Gln Thr Lys Arg Gly Lys 
        35                  40                  45              


Gln Val Cys Ala Asp Pro Ser Glu Ser Trp Val Gln Glu Tyr Val Tyr 
    50                  55                  60                  


Asp Leu Glu Leu Asn 
65                  


<210>  73
<211>  68
<212>  PRT
<213>  Homo sapiens

<220>
<221>  MISC_FEATURE
<222>  (1)..(68)
<223>  Human RANTES, CCL5

<400>  73

Ser Pro Tyr Ser Ser Asp Thr Thr Pro Cys Cys Phe Ala Tyr Ile Ala 
1               5                   10                  15      


Arg Pro Leu Pro Arg Ala His Ile Lys Glu Tyr Phe Tyr Thr Ser Gly 
            20                  25                  30          


Lys Cys Ser Asn Pro Ala Val Val Phe Val Thr Arg Lys Asn Arg Gln 
        35                  40                  45              


Val Cys Ala Asn Pro Glu Lys Lys Trp Val Arg Glu Tyr Ile Asn Ser 
    50                  55                  60                  


Leu Glu Met Ser 
65              


<210>  74
<211>  76
<212>  PRT
<213>  Homo sapiens

<220>
<221>  MISC_FEATURE
<222>  (1)..(76)
<223>  Human MCP-1, CCL2

<400>  74

Gln Pro Asp Ala Ile Asn Ala Pro Val Thr Cys Cys Tyr Asn Phe Thr 
1               5                   10                  15      


Asn Arg Lys Ile Ser Val Gln Arg Leu Ala Ser Tyr Arg Arg Ile Thr 
            20                  25                  30          


Ser Ser Lys Cys Pro Lys Glu Ala Val Ile Phe Lys Thr Ile Val Ala 
        35                  40                  45              


Lys Glu Ile Cys Ala Asp Pro Lys Gln Lys Trp Val Gln Asp Ser Met 
    50                  55                  60                  


Asp His Leu Asp Lys Gln Thr Gln Thr Pro Lys Thr 
65                  70                  75      


<210>  75
<211>  76
<212>  PRT
<213>  Homo sapiens

<220>
<221>  MISC_FEATURE
<222>  (1)..(76)
<223>  Human MCP-2, CCL8


<400>  75

Gln Pro Asp Ser Val Ser Ile Pro Ile Thr Cys Cys Phe Asn Val Ile 
1               5                   10                  15      


Asn Arg Lys Ile Pro Ile Gln Arg Leu Glu Ser Tyr Thr Arg Ile Thr 
            20                  25                  30          


Asn Ile Gln Cys Pro Lys Glu Ala Val Ile Phe Lys Thr Lys Arg Gly 
        35                  40                  45              


Lys Glu Val Cys Ala Asp Pro Lys Glu Arg Trp Val Arg Asp Ser Met 
    50                  55                  60                  


Lys His Leu Asp Gln Ile Phe Gln Asn Leu Lys Pro 
65                  70                  75      


<210>  76
<211>  76
<212>  PRT
<213>  Homo sapiens

<220>
<221>  MISC_FEATURE
<222>  (1)..(76)
<223>  Human MCP-3, CCL7


<400>  76

Gln Pro Val Gly Ile Asn Thr Ser Thr Thr Cys Cys Tyr Arg Phe Ile 
1               5                   10                  15      


Asn Lys Lys Ile Pro Lys Gln Arg Leu Glu Ser Tyr Arg Arg Thr Thr 
            20                  25                  30          


Ser Ser His Cys Pro Arg Glu Ala Val Ile Phe Lys Thr Lys Leu Asp 
        35                  40                  45              


Lys Glu Ile Cys Ala Asp Pro Thr Gln Lys Trp Val Gln Asp Phe Met 
    50                  55                  60                  


Lys His Leu Asp Lys Lys Thr Gln Thr Pro Lys Leu 
65                  70                  75      


<210>  77
<211>  75
<212>  PRT
<213>  Homo sapiens

<220>
<221>  MISC_FEATURE
<222>  (1)..(75)
<223>  Human MCP-4, CCL13


<400>  77

Gln Pro Asp Ala Leu Asn Val Pro Ser Thr Cys Cys Phe Thr Phe Ser 
1               5                   10                  15      


Ser Lys Lys Ile Ser Leu Gln Arg Leu Lys Ser Tyr Val Ile Thr Thr 
            20                  25                  30          


Ser Arg Cys Pro Gln Lys Ala Val Ile Phe Arg Thr Lys Leu Gly Lys 
        35                  40                  45              


Glu Ile Cys Ala Asp Pro Lys Glu Lys Trp Val Gln Asn Tyr Met Lys 
    50                  55                  60                  


His Leu Gly Arg Lys Ala His Thr Leu Lys Thr 
65                  70                  75  


<210>  78
<211>  66
<212>  PRT
<213>  Homo sapiens

<220>
<221>  MISC_FEATURE
<222>  (1)..(66)
<223>  Human HCC-1/CCL14a


<400>  78

Gly Pro Tyr His Pro Ser Glu Cys Cys Phe Thr Tyr Thr Thr Tyr Lys 
1               5                   10                  15      


Ile Pro Arg Gln Arg Ile Met Asp Tyr Tyr Glu Thr Asn Ser Gln Cys 
            20                  25                  30          


Ser Lys Pro Gly Ile Val Phe Ile Thr Lys Arg Gly His Ser Val Cys 
        35                  40                  45              


Thr Asn Pro Ser Asp Lys Trp Val Gln Asp Tyr Ile Lys Asp Met Lys 
    50                  55                  60                  


Glu Asn 
65      


<210>  79
<211>  68
<212>  PRT
<213>  Homo sapiens

<220>
<221>  MISC_FEATURE
<222>  (1)..(68)
<223>  Human HCC-2/MIP1-delta/CCL15


<400>  79

Ser Phe His Phe Ala Ala Asp Cys Cys Thr Ser Tyr Ile Ser Gln Ser 
1               5                   10                  15      


Ile Pro Cys Ser Leu Met Lys Ser Tyr Phe Glu Thr Ser Ser Glu Cys 
            20                  25                  30          


Ser Lys Pro Gly Val Ile Phe Leu Thr Lys Lys Gly Arg Gln Val Cys 
        35                  40                  45              


Ala Lys Pro Ser Gly Pro Gly Val Gln Asp Cys Met Lys Lys Leu Lys 
    50                  55                  60                  


Pro Tyr Ser Ile 
65              


<210>  80
<211>  97
<212>  PRT
<213>  Homo sapiens

<220>
<221>  MISC_FEATURE
<222>  (1)..(97)
<223>  Human HCC-4, CCL16


<400>  80

Gln Pro Lys Val Pro Glu Trp Val Asn Thr Pro Ser Thr Cys Cys Leu 
1               5                   10                  15      


Lys Tyr Tyr Glu Lys Val Leu Pro Arg Arg Leu Val Val Gly Tyr Arg 
            20                  25                  30          


Lys Ala Leu Asn Cys His Leu Pro Ala Ile Ile Phe Val Thr Lys Arg 
        35                  40                  45              


Asn Arg Glu Val Cys Thr Asn Pro Asn Asp Asp Trp Val Gln Glu Tyr 
    50                  55                  60                  


Ile Lys Asp Pro Asn Leu Pro Leu Leu Pro Thr Arg Asn Leu Ser Thr 
65                  70                  75                  80  


Val Lys Ile Ile Thr Ala Lys Asn Gly Gln Pro Gln Leu Leu Asn Ser 
                85                  90                  95      


Gln 
    


<210>  81
<211>  75
<212>  PRT
<213>  Homo sapiens

<220>
<221>  MISC_FEATURE
<222>  (1)..(75)
<223>  Human MPIF-1, CCL23

<400>  81

Arg Phe His Ala Thr Ser Ala Asp Cys Cys Ile Ser Tyr Thr Pro Arg 
1               5                   10                  15      


Ser Ile Pro Cys Ser Leu Leu Glu Ser Tyr Phe Glu Thr Asn Ser Glu 
            20                  25                  30          


Cys Ser Lys Pro Gly Val Ile Phe Leu Thr Lys Lys Gly Arg Arg Phe 
        35                  40                  45              


Cys Ala Asn Pro Ser Asp Lys Gln Val Gln Val Cys Met Arg Met Leu 
    50                  55                  60                  


Lys Leu Asp Thr Arg Ile Lys Thr Arg Lys Asn 
65                  70                  75  


<210>  82
<211>  69
<212>  PRT
<213>  Homo sapiens

<220>
<221>  MISC_FEATURE
<222>  (1)..(69)
<223>  Human PARC, CCL18


<400>  82

Ala Gln Val Gly Thr Asn Lys Glu Leu Cys Cys Leu Val Tyr Thr Ser 
1               5                   10                  15      


Trp Gln Ile Pro Gln Lys Phe Ile Val Asp Tyr Ser Glu Thr Ser Pro 
            20                  25                  30          


Gln Cys Pro Lys Pro Gly Val Ile Leu Leu Thr Lys Arg Gly Arg Gln 
        35                  40                  45              


Ile Cys Ala Asp Pro Asn Lys Lys Trp Val Gln Lys Tyr Ile Ser Asp 
    50                  55                  60                  


Leu Lys Leu Asn Ala 
65                  


<210>  83
<211>  74
<212>  PRT
<213>  Homo sapiens

<400>  83

Gly Pro Ala Ser Val Pro Thr Thr Cys Cys Phe Asn Leu Ala Asn Arg 
1               5                   10                  15      


Lys Ile Pro Leu Gln Arg Leu Glu Ser Tyr Arg Arg Ile Thr Ser Gly 
            20                  25                  30          


Lys Cys Pro Gln Lys Ala Val Ile Phe Lys Thr Lys Leu Ala Lys Asp 
        35                  40                  45              


Ile Cys Ala Asp Pro Lys Lys Lys Trp Val Gln Asp Ser Met Lys Tyr 
    50                  55                  60                  


Leu Asp Gln Lys Ser Pro Thr Pro Lys Pro 
65                  70                  


<210>  84
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  84

Val Val Ile Pro Ser Pro Cys Cys Met Phe Phe Val Ser Lys Arg Ile 
1               5                   10                  15      


Pro Glu Asn Arg Val Val Ser Tyr Gln Leu Ser Ser Arg Ser Thr Cys 
            20                  25                  30          


Leu Lys Gly Gly Val Ile Phe Thr Thr Lys Lys Gly Gln Gln Phe Cys 
        35                  40                  45              


Gly Asp Pro Lys Gln Glu Trp Val Gln Arg Tyr Met Lys Asn Leu Asp 
    50                  55                  60                  


Ala Lys Gln Lys Lys Ala Ser Pro Arg Ala Arg Ala Val Ala Val Lys 
65                  70                  75                  80  


Gly Pro Val Gln Arg Tyr Pro Gly Asn Gln Thr Thr Cys 
                85                  90              


<210>  85
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  85

Thr Arg Gly Ser Asp Ile Ser Lys Thr Cys Cys Phe Gln Tyr Ser His 
1               5                   10                  15      


Lys Pro Leu Pro Trp Thr Trp Val Arg Ser Tyr Glu Phe Thr Ser Asn 
            20                  25                  30          


Ser Cys Ser Gln Arg Ala Val Ile Phe Thr Thr Lys Arg Gly Lys Lys 
        35                  40                  45              


Val Cys Thr His Pro Arg Lys Lys Trp Val Gln Lys Tyr Ile Ser Leu 
    50                  55                  60                  


Leu Lys Thr Pro Lys Gln Leu 
65                  70      


<210>  86
<211>  69
<212>  PRT
<213>  Homo sapiens

<400>  86

Gly Pro Tyr Gly Ala Asn Met Glu Asp Ser Val Cys Cys Arg Asp Tyr 
1               5                   10                  15      


Val Arg Tyr Arg Leu Pro Leu Arg Val Val Lys His Phe Tyr Trp Thr 
            20                  25                  30          


Ser Asp Ser Cys Pro Arg Pro Gly Val Val Leu Leu Thr Phe Arg Asp 
        35                  40                  45              


Lys Glu Ile Cys Ala Asp Pro Arg Val Pro Trp Val Lys Met Ile Leu 
    50                  55                  60                  


Asn Lys Leu Ser Gln 
65                  


<210>  87
<211>  71
<212>  PRT
<213>  Homo sapiens

<400>  87

Ala Arg Gly Thr Asn Val Gly Arg Glu Cys Cys Leu Glu Tyr Phe Lys 
1               5                   10                  15      


Gly Ala Ile Pro Leu Arg Lys Leu Lys Thr Trp Tyr Gln Thr Ser Glu 
            20                  25                  30          


Asp Cys Ser Arg Asp Ala Ile Val Phe Val Thr Val Gln Gly Arg Ala 
        35                  40                  45              


Ile Cys Ser Asp Pro Asn Asn Lys Arg Val Lys Asn Ala Val Lys Tyr 
    50                  55                  60                  


Leu Gln Ser Leu Glu Arg Ser 
65                  70      


<210>  88
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  88

Ala Ser Asn Phe Asp Cys Cys Leu Gly Tyr Thr Asp Arg Ile Leu His 
1               5                   10                  15      


Pro Lys Phe Ile Val Gly Phe Thr Arg Gln Leu Ala Asn Glu Gly Cys 
            20                  25                  30          


Asp Ile Asn Ala Ile Ile Phe His Thr Lys Lys Lys Leu Ser Val Cys 
        35                  40                  45              


Ala Asn Pro Lys Gln Thr Trp Val Lys Tyr Ile Val Arg Leu Leu Ser 
    50                  55                  60                  


Lys Lys Val Lys Asn Met 
65                  70  


<210>  89
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  89

Gly Thr Asn Asp Ala Glu Asp Cys Cys Leu Ser Val Thr Gln Lys Pro 
1               5                   10                  15      


Ile Pro Gly Tyr Ile Val Arg Asn Phe His Tyr Leu Leu Ile Lys Asp 
            20                  25                  30          


Gly Cys Arg Val Pro Ala Val Val Phe Thr Thr Leu Arg Gly Arg Gln 
        35                  40                  45              


Leu Cys Ala Pro Pro Asp Gln Pro Trp Val Glu Arg Ile Ile Gln Arg 
    50                  55                  60                  


Leu Gln Arg Thr Ser Ala Lys Met Lys Arg Arg Ser Ser 
65                  70                  75          


<210>  90
<211>  111
<212>  PRT
<213>  Homo sapiens

<400>  90

Ser Asp Gly Gly Ala Gln Asp Cys Cys Leu Lys Tyr Ser Gln Arg Lys 
1               5                   10                  15      


Ile Pro Ala Lys Val Val Arg Ser Tyr Arg Lys Gln Glu Pro Ser Leu 
            20                  25                  30          


Gly Cys Ser Ile Pro Ala Ile Leu Phe Leu Pro Arg Lys Arg Ser Gln 
        35                  40                  45              


Ala Glu Leu Cys Ala Asp Pro Lys Glu Leu Trp Val Gln Gln Leu Met 
    50                  55                  60                  


Gln His Leu Asp Lys Thr Pro Ser Pro Gln Lys Pro Ala Gln Gly Cys 
65                  70                  75                  80  


Arg Lys Asp Arg Gly Ala Ser Lys Thr Gly Lys Lys Gly Lys Gly Ser 
                85                  90                  95      


Lys Gly Cys Lys Arg Thr Glu Arg Ser Gln Thr Pro Lys Gly Pro 
            100                 105                 110     


<210>  91
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  91

Lys Ser Met Gln Val Pro Phe Ser Arg Cys Cys Phe Ser Phe Ala Glu 
1               5                   10                  15      


Gln Glu Ile Pro Leu Arg Ala Ile Leu Cys Tyr Arg Asn Thr Ser Ser 
            20                  25                  30          


Ile Cys Ser Asn Glu Gly Leu Ile Phe Lys Leu Lys Arg Gly Lys Glu 
        35                  40                  45              


Ala Cys Ala Leu Asp Thr Val Gly Trp Val Gln Arg His Arg Lys Met 
    50                  55                  60                  


Leu Arg His Cys Pro Ser Lys Arg Lys 
65                  70              


<210>  92
<211>  127
<212>  PRT
<213>  Homo sapiens

<400>  92

Gln Gly Val Phe Glu Asp Cys Cys Leu Ala Tyr His Tyr Pro Ile Gly 
1               5                   10                  15      


Trp Ala Val Leu Arg Arg Ala Trp Thr Tyr Arg Ile Gln Glu Val Ser 
            20                  25                  30          


Gly Ser Cys Asn Leu Pro Ala Ala Ile Phe Tyr Leu Pro Lys Arg His 
        35                  40                  45              


Arg Lys Val Cys Gly Asn Pro Lys Ser Arg Glu Val Gln Arg Ala Met 
    50                  55                  60                  


Lys Leu Leu Asp Ala Arg Asn Lys Val Phe Ala Lys Leu His His Asn 
65                  70                  75                  80  


Met Gln Thr Phe Gln Ala Gly Pro His Ala Val Lys Lys Leu Ser Ser 
                85                  90                  95      


Gly Asn Ser Lys Leu Ser Ser Ser Lys Phe Ser Asn Pro Ile Ser Ser 
            100                 105                 110         


Ser Lys Arg Asn Val Ser Leu Leu Ile Ser Ala Asn Ser Gly Leu 
        115                 120                 125         


<210>  93
<211>  88
<212>  PRT
<213>  Homo sapiens

<400>  93

Phe Leu Leu Pro Pro Ser Thr Ala Cys Cys Thr Gln Leu Tyr Arg Lys 
1               5                   10                  15      


Pro Leu Ser Asp Lys Leu Leu Arg Lys Val Ile Gln Val Glu Leu Gln 
            20                  25                  30          


Glu Ala Asp Gly Asp Cys His Leu Gln Ala Phe Val Leu His Leu Ala 
        35                  40                  45              


Gln Arg Ser Ile Cys Ile His Pro Gln Asn Pro Ser Leu Ser Gln Trp 
    50                  55                  60                  


Phe Glu His Gln Glu Arg Lys Leu His Gly Thr Leu Pro Lys Leu Asn 
65                  70                  75                  80  


Phe Gly Met Leu Arg Lys Met Gly 
                85              


<210>  94
<211>  105
<212>  PRT
<213>  Homo sapiens

<400>  94

Ile Leu Pro Ile Ala Ser Ser Cys Cys Thr Glu Val Ser His His Ile 
1               5                   10                  15      


Ser Arg Arg Leu Leu Glu Arg Val Asn Met Cys Arg Ile Gln Arg Ala 
            20                  25                  30          


Asp Gly Asp Cys Asp Leu Ala Ala Val Ile Leu His Val Lys Arg Arg 
        35                  40                  45              


Arg Ile Cys Val Ser Pro His Asn His Thr Val Lys Gln Trp Met Lys 
    50                  55                  60                  


Val Gln Ala Ala Lys Lys Asn Gly Lys Gly Asn Val Cys His Arg Lys 
65                  70                  75                  80  


Lys His His Gly Lys Arg Asn Ser Asn Arg Ala His Gln Gly Lys His 
                85                  90                  95      


Glu Thr Tyr Gly His Lys Thr Pro Tyr 
            100                 105 


<210>  95
<211>  94
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Val Gly Ser Glu Val Ser Asp Lys Arg Thr Cys Val Ser Leu Thr 
1               5                   10                  15      


Thr Gln Arg Leu Pro Val Ser Arg Ile Lys Thr Tyr Thr Ile Thr Glu 
            20                  25                  30          


Gly Ser Leu Arg Ala Val Ile Phe Ile Thr Lys Arg Gly Leu Lys Val 
        35                  40                  45              


Cys Ala Asp Pro Gln Ala Thr Trp Val Arg Asp Val Val Arg Ser Met 
    50                  55                  60                  


Asp Arg Lys Ser Asn Thr Arg Asn Asn Met Ile Gln Thr Lys Pro Thr 
65                  70                  75                  80  


Gly Thr Gln Gln Ser Thr Asn Thr Ala Val Thr Leu Thr Gly 
                85                  90                  


<210>  96
<211>  339
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Ala Pro Ile Ser Leu Ser Trp Leu Leu Arg Leu Ala Thr Phe Cys 
1               5                   10                  15      


His Leu Thr Val Leu Leu Ala Gly Gln His His Gly Val Thr Lys Cys 
            20                  25                  30          


Asn Ile Thr Cys Ser Lys Met Thr Ser Lys Ile Pro Val Ala Leu Leu 
        35                  40                  45              


Ile His Tyr Gln Gln Asn Gln Ala Ser Cys Gly Lys Arg Ala Ile Ile 
    50                  55                  60                  


Leu Glu Thr Arg Gln His Arg Leu Phe Cys Ala Asp Pro Lys Glu Gln 
65                  70                  75                  80  


Trp Val Lys Asp Ala Met Gln His Leu Asp Arg Gln Ala Ala Ala Leu 
                85                  90                  95      


Thr Arg Asn Gly Gly Thr Phe Glu Lys Gln Ile Gly Glu Val Lys Pro 
            100                 105                 110         


Arg Thr Thr Pro Ala Ala Gly Gly Met Asp Glu Ser Val Val Leu Glu 
        115                 120                 125             


Pro Glu Ala Thr Gly Glu Ser Ser Ser Leu Glu Pro Thr Pro Ser Ser 
    130                 135                 140                 


Gln Glu Ala Gln Arg Ala Leu Gly Thr Ser Pro Glu Leu Pro Thr Gly 
145                 150                 155                 160 


Val Thr Gly Ser Ser Gly Thr Arg Leu Pro Pro Thr Pro Lys Ala Gln 
                165                 170                 175     


Asp Gly Gly Pro Val Gly Thr Glu Leu Phe Arg Val Pro Pro Val Ser 
            180                 185                 190         


Thr Ala Ala Thr Trp Gln Ser Ser Ala Pro His Gln Pro Gly Pro Ser 
        195                 200                 205             


Leu Trp Ala Glu Ala Lys Thr Ser Glu Ala Pro Ser Thr Gln Asp Pro 
    210                 215                 220                 


Ser Thr Gln Ala Ser Thr Ala Ser Ser Pro Ala Pro Glu Glu Asn Ala 
225                 230                 235                 240 


Pro Ser Glu Gly Gln Arg Val Trp Gly Gln Gly Gln Ser Pro Arg Pro 
                245                 250                 255     


Glu Asn Ser Leu Glu Arg Glu Glu Met Gly Pro Val Pro Ala His Thr 
            260                 265                 270         


Asp Ala Phe Gln Asp Trp Gly Pro Gly Ser Met Ala His Val Ser Val 
        275                 280                 285             


Val Pro Val Ser Ser Glu Gly Thr Pro Ser Arg Glu Pro Val Ala Ser 
    290                 295                 300                 


Gly Ser Trp Thr Pro Lys Ala Glu Glu Pro Ile His Ala Thr Met Asp 
305                 310                 315                 320 


Pro Gln Arg Leu Gly Val Leu Ile Thr Pro Val Pro Asp Ala Gln Ala 
                325                 330                 335     


Ala Thr Arg 
            


<210>  97
<211>  72
<212>  PRT
<213>  Homo sapiens

<400>  97

Ser Ala Lys Glu Leu Arg Cys Gln Cys Ile Lys Thr Tyr Ser Lys Pro 
1               5                   10                  15      


Phe His Pro Lys Phe Ile Lys Glu Leu Arg Val Ile Glu Ser Gly Pro 
            20                  25                  30          


His Cys Ala Asn Thr Glu Ile Ile Val Lys Leu Ser Asp Gly Arg Glu 
        35                  40                  45              


Leu Cys Leu Asp Pro Lys Glu Asn Trp Val Gln Arg Val Val Glu Lys 
    50                  55                  60                  


Phe Leu Lys Arg Ala Glu Asn Ser 
65                  70          


<210>  98
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  98

Ala Ser Val Ala Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr Leu Gln 
1               5                   10                  15      


Gly Ile His Pro Lys Asn Ile Gln Ser Val Asn Val Lys Ser Pro Gly 
            20                  25                  30          


Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn Gly Arg 
        35                  40                  45              


Lys Ala Cys Leu Asn Pro Ala Ser Pro Ile Val Lys Lys Ile Ile Glu 
    50                  55                  60                  


Lys Met Leu Asn Ser Asp Lys Ser Asn 
65                  70              


<210>  99
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  99

Ala Pro Leu Ala Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr Leu Gln 
1               5                   10                  15      


Gly Ile His Leu Lys Asn Ile Gln Ser Val Lys Val Lys Ser Pro Gly 
            20                  25                  30          


Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn Gly Gln 
        35                  40                  45              


Lys Ala Cys Leu Asn Pro Ala Ser Pro Met Val Lys Lys Ile Ile Glu 
    50                  55                  60                  


Lys Met Leu Lys Asn Gly Lys Ser Asn 
65                  70              


<210>  100
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  100

Ala Ser Val Val Thr Glu Leu Arg Cys Gln Cys Leu Gln Thr Leu Gln 
1               5                   10                  15      


Gly Ile His Leu Lys Asn Ile Gln Ser Val Asn Val Arg Ser Pro Gly 
            20                  25                  30          


Pro His Cys Ala Gln Thr Glu Val Ile Ala Thr Leu Lys Asn Gly Lys 
        35                  40                  45              


Lys Ala Cys Leu Asn Pro Ala Ser Pro Met Val Gln Lys Ile Ile Glu 
    50                  55                  60                  


Lys Ile Leu Asn Lys Gly Ser Thr Asn 
65                  70              


<210>  101
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  101

Ala Gly Pro Ala Ala Ala Val Leu Arg Glu Leu Arg Cys Val Cys Leu 
1               5                   10                  15      


Gln Thr Thr Gln Gly Val His Pro Lys Met Ile Ser Asn Leu Gln Val 
            20                  25                  30          


Phe Ala Ile Gly Pro Gln Cys Ser Lys Val Glu Val Val Ala Ser Leu 
        35                  40                  45              


Lys Asn Gly Lys Glu Ile Cys Leu Asp Pro Glu Ala Pro Phe Leu Lys 
    50                  55                  60                  


Lys Val Ile Gln Lys Ile Leu Asp Gly Gly Asn Lys Glu Asn 
65                  70                  75              


<210>  102
<211>  75
<212>  PRT
<213>  Homo sapiens

<400>  102

Val Ser Ala Val Leu Thr Glu Leu Arg Cys Thr Cys Leu Arg Val Thr 
1               5                   10                  15      


Leu Arg Val Asn Pro Lys Thr Ile Gly Lys Leu Gln Val Phe Pro Ala 
            20                  25                  30          


Gly Pro Gln Cys Ser Lys Val Glu Val Val Ala Ser Leu Lys Asn Gly 
        35                  40                  45              


Lys Gln Val Cys Leu Asp Pro Glu Ala Pro Phe Leu Lys Lys Val Ile 
    50                  55                  60                  


Gln Lys Ile Leu Asp Ser Gly Asn Lys Lys Asn 
65                  70                  75  


<210>  103
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  103

Ala Glu Leu Arg Cys Met Cys Ile Lys Thr Thr Ser Gly Ile His Pro 
1               5                   10                  15      


Lys Asn Ile Gln Ser Leu Glu Val Ile Gly Lys Gly Thr His Cys Asn 
            20                  25                  30          


Gln Val Glu Val Ile Ala Thr Leu Lys Asp Gly Arg Lys Ile Cys Leu 
        35                  40                  45              


Asp Pro Asp Ala Pro Arg Ile Lys Lys Ile Val Gln Lys Lys Leu Ala 
    50                  55                  60                  


Gly Asp Glu Ser Ala Asp 
65                  70  


<210>  104
<211>  70
<212>  PRT
<213>  Homo sapiens

<400>  104

Glu Ala Glu Glu Asp Gly Asp Leu Gln Cys Leu Cys Val Lys Thr Thr 
1               5                   10                  15      


Ser Gln Val Arg Pro Arg His Ile Thr Ser Leu Glu Val Ile Lys Ala 
            20                  25                  30          


Gly Pro His Cys Pro Thr Ala Gln Leu Ile Ala Thr Leu Lys Asn Gly 
        35                  40                  45              


Arg Lys Ile Cys Leu Asp Leu Gln Ala Pro Leu Tyr Lys Lys Ile Ile 
    50                  55                  60                  


Lys Lys Leu Leu Glu Ser 
65                  70  


<210>  105
<211>  78
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Val Pro Leu Ser Arg Thr Val Arg Cys Thr Cys Ile Ser Ile Ser 
1               5                   10                  15      


Asn Gln Pro Val Asn Pro Arg Ser Leu Glu Lys Leu Glu Ile Ile Pro 
            20                  25                  30          


Ala Ser Gln Phe Cys Pro Arg Val Glu Ile Ile Ala Thr Met Lys Lys 
        35                  40                  45              


Lys Gly Glu Lys Arg Cys Leu Asn Pro Glu Ser Lys Ala Ile Lys Asn 
    50                  55                  60                  


Leu Leu Lys Ala Val Ser Lys Glu Arg Ser Lys Arg Ser Pro 
65                  70                  75              


<210>  106
<211>  103
<212>  PRT
<213>  Homo sapiens

<400>  106

Thr Pro Val Val Arg Lys Gly Arg Cys Ser Cys Ile Ser Thr Asn Gln 
1               5                   10                  15      


Gly Thr Ile His Leu Gln Ser Leu Lys Asp Leu Lys Gln Phe Ala Pro 
            20                  25                  30          


Ser Pro Ser Cys Glu Lys Ile Glu Ile Ile Ala Thr Leu Lys Asn Gly 
        35                  40                  45              


Val Gln Thr Cys Leu Asn Pro Asp Ser Ala Asp Val Lys Glu Leu Ile 
    50                  55                  60                  


Lys Lys Thr Glu Lys Gln Val Ser Gln Lys Lys Lys Gln Lys Asn Gly 
65                  70                  75                  80  


Lys Lys His Gln Lys Lys Lys Val Leu Lys Val Arg Lys Ser Gln Arg 
                85                  90                  95      


Ser Arg Gln Lys Lys Thr Thr 
            100             


<210>  107
<211>  73
<212>  PRT
<213>  Homo sapiens

<400>  107

Phe Pro Met Phe Lys Arg Gly Arg Cys Leu Cys Ile Gly Pro Gly Val 
1               5                   10                  15      


Lys Ala Val Lys Val Ala Asp Ile Glu Lys Ala Ser Ile Met Tyr Pro 
            20                  25                  30          


Ser Asn Asn Cys Asp Lys Ile Glu Val Ile Ile Thr Leu Lys Glu Asn 
        35                  40                  45              


Lys Gly Gln Arg Cys Leu Asn Pro Lys Ser Lys Gln Ala Arg Leu Ile 
    50                  55                  60                  


Ile Lys Lys Val Glu Arg Lys Asn Phe 
65                  70              


<210>  108
<211>  68
<212>  PRT
<213>  Homo sapiens

<400>  108

Lys Pro Val Ser Leu Ser Tyr Arg Cys Pro Cys Arg Phe Phe Glu Ser 
1               5                   10                  15      


His Val Ala Arg Ala Asn Val Lys His Leu Lys Ile Leu Asn Thr Pro 
            20                  25                  30          


Asn Cys Ala Leu Gln Ile Val Ala Arg Leu Lys Asn Asn Asn Arg Gln 
        35                  40                  45              


Val Cys Ile Asp Pro Lys Leu Lys Trp Ile Gln Glu Tyr Leu Glu Lys 
    50                  55                  60                  


Ala Leu Asn Lys 
65              


<210>  109
<211>  87
<212>  PRT
<213>  Homo sapiens

<400>  109

Val Leu Glu Val Tyr Tyr Thr Ser Leu Arg Cys Arg Cys Val Gln Glu 
1               5                   10                  15      


Ser Ser Val Phe Ile Pro Arg Arg Phe Ile Asp Arg Ile Gln Ile Leu 
            20                  25                  30          


Pro Arg Gly Asn Gly Cys Pro Arg Lys Glu Ile Ile Val Trp Lys Lys 
        35                  40                  45              


Asn Lys Ser Ile Val Cys Val Asp Pro Gln Ala Glu Trp Ile Gln Arg 
    50                  55                  60                  


Met Met Glu Val Leu Arg Lys Arg Ser Ser Ser Thr Leu Pro Val Pro 
65                  70                  75                  80  


Val Phe Lys Arg Lys Ile Pro 
                85          


<210>  110
<211>  89
<212>  PRT
<213>  Homo sapiens

<400>  110

Asn Glu Gly Ser Val Thr Gly Ser Cys Tyr Cys Gly Lys Arg Ile Ser 
1               5                   10                  15      


Ser Asp Ser Pro Pro Ser Val Gln Phe Met Asn Arg Leu Arg Lys His 
            20                  25                  30          


Leu Arg Ala Tyr His Arg Cys Leu Tyr Tyr Thr Arg Phe Gln Leu Leu 
        35                  40                  45              


Ser Trp Ser Val Cys Gly Gly Asn Lys Asp Pro Trp Val Gln Glu Leu 
    50                  55                  60                  


Met Ser Cys Leu Asp Leu Lys Glu Cys Gly His Ala Tyr Ser Gly Ile 
65                  70                  75                  80  


Val Ala His Gln Lys His Leu Leu Pro 
                85                  


<210>  111
<211>  77
<212>  PRT
<213>  Homo sapiens

<400>  111

Ser Lys Cys Lys Cys Ser Arg Lys Gly Pro Lys Ile Arg Tyr Ser Asp 
1               5                   10                  15      


Val Lys Lys Leu Glu Met Lys Pro Lys Tyr Pro His Cys Glu Glu Lys 
            20                  25                  30          


Met Val Ile Ile Thr Thr Lys Ser Val Ser Arg Tyr Arg Gly Gln Glu 
        35                  40                  45              


His Cys Leu His Pro Lys Leu Gln Ser Thr Lys Arg Phe Ile Lys Trp 
    50                  55                  60                  


Tyr Asn Ala Trp Asn Glu Lys Arg Arg Val Tyr Glu Glu 
65                  70                  75          


<210>  112
<211>  69
<212>  PRT
<213>  Mus musculus

<220>
<221>  MISC_FEATURE
<222>  (1)..(69)
<223>  Murine MIP-1alpha, CCL3

<400>  112

Ala Pro Tyr Gly Ala Asp Thr Pro Thr Ala Cys Cys Phe Ser Tyr Ser 
1               5                   10                  15      


Arg Lys Ile Pro Arg Gln Phe Ile Val Asp Tyr Phe Glu Thr Ser Ser 
            20                  25                  30          


Leu Cys Ser Gln Pro Gly Val Ile Phe Leu Thr Lys Arg Asn Arg Gln 
        35                  40                  45              


Ile Cys Ala Asp Ser Lys Glu Thr Trp Val Gln Glu Tyr Ile Thr Asp 
    50                  55                  60                  


Leu Glu Leu Asn Ala 
65                  


<210>  113
<211>  69
<212>  PRT
<213>  Mus musculus

<220>
<221>  MISC_FEATURE
<222>  (1)..(69)
<223>  Murine MIP-1beta, CCL4

<400>  113

Ala Pro Met Gly Ser Asp Pro Pro Thr Ser Cys Cys Phe Ser Tyr Thr 
1               5                   10                  15      


Ser Arg Gln Leu His Arg Ser Phe Val Met Asp Tyr Tyr Glu Thr Ser 
            20                  25                  30          


Ser Leu Cys Ser Lys Pro Ala Val Val Phe Leu Thr Lys Arg Gly Arg 
        35                  40                  45              


Gln Ile Cys Ala Asn Pro Ser Glu Pro Trp Val Thr Glu Tyr Met Ser 
    50                  55                  60                  


Asp Leu Glu Leu Asn 
65                  


<210>  114
<211>  68
<212>  PRT
<213>  Mus musculus

<220>
<221>  MISC_FEATURE
<222>  (1)..(68)
<223>  Murine RANTES, CCL5

<400>  114

Ser Pro Tyr Gly Ser Asp Thr Thr Pro Cys Cys Phe Ala Tyr Leu Ser 
1               5                   10                  15      


Leu Ala Leu Pro Arg Ala His Val Lys Glu Tyr Phe Tyr Thr Ser Ser 
            20                  25                  30          


Lys Cys Ser Asn Leu Ala Val Val Phe Val Thr Arg Arg Asn Arg Gln 
        35                  40                  45              


Val Cys Ala Asn Pro Glu Lys Lys Trp Val Gln Glu Tyr Ile Asn Tyr 
    50                  55                  60                  


Leu Glu Met Ser 
65              


<210>  115
<211>  125
<212>  PRT
<213>  Mus musculus

<220>
<221>  MISC_FEATURE
<222>  (1)..(125)
<223>  Murine MCP-1, CCL2

<400>  115

Gln Pro Asp Ala Val Asn Ala Pro Leu Thr Cys Cys Tyr Ser Phe Thr 
1               5                   10                  15      


Ser Lys Met Ile Pro Met Ser Arg Leu Glu Ser Tyr Lys Arg Ile Thr 
            20                  25                  30          


Ser Ser Arg Cys Pro Lys Glu Ala Val Val Phe Val Thr Lys Leu Lys 
        35                  40                  45              


Arg Glu Val Cys Ala Asp Pro Lys Lys Glu Trp Val Gln Thr Tyr Ile 
    50                  55                  60                  


Lys Asn Leu Asp Arg Asn Gln Met Arg Ser Glu Pro Thr Thr Leu Phe 
65                  70                  75                  80  


Lys Thr Ala Ser Ala Leu Arg Ser Ser Ala Pro Leu Asn Val Lys Leu 
                85                  90                  95      


Thr Arg Lys Ser Glu Ala Asn Ala Ser Thr Thr Phe Ser Thr Thr Thr 
            100                 105                 110         


Ser Ser Thr Ser Val Gly Val Thr Ser Val Thr Val Asn 
        115                 120                 125 


<210>  116
<211>  82
<212>  PRT
<213>  Mus musculus

<220>
<221>  MISC_FEATURE
<222>  (1)..(82)
<223>  Murine MCP-5, CCL12


<400>  116

Gly Pro Asp Ala Val Ser Thr Pro Val Thr Cys Cys Tyr Asn Val Val 
1               5                   10                  15      


Lys Gln Lys Ile His Val Arg Lys Leu Lys Ser Tyr Arg Arg Ile Thr 
            20                  25                  30          


Ser Ser Gln Cys Pro Arg Glu Ala Val Ile Phe Arg Thr Ile Leu Asp 
        35                  40                  45              


Lys Glu Ile Cys Ala Asp Pro Lys Glu Lys Trp Val Lys Asn Ser Ile 
    50                  55                  60                  


Asn His Leu Asp Lys Thr Ser Gln Thr Phe Ile Leu Glu Pro Ser Cys 
65                  70                  75                  80  


Leu Gly 
        


<210>  117
<211>  246
<212>  PRT
<213>  Cowpox virus

<400>  117

Met Lys Gln Ile Val Leu Ala Cys Ile Cys Leu Ala Ala Val Ala Ile 
1               5                   10                  15      


Pro Thr Ser Leu Gln Gln Ser Phe Ser Ser Ser Ser Ser Cys Thr Glu 
            20                  25                  30          


Glu Glu Asn Lys His His Met Gly Ile Asp Val Ile Ile Lys Val Thr 
        35                  40                  45              


Lys Gln Asp Gln Thr Pro Thr Asn Asp Lys Ile Cys Gln Ser Val Thr 
    50                  55                  60                  


Glu Val Thr Glu Ser Glu Asp Glu Ser Glu Glu Val Val Lys Gly Asp 
65                  70                  75                  80  


Pro Thr Thr Tyr Tyr Thr Val Val Gly Gly Gly Leu Thr Met Asp Phe 
                85                  90                  95      


Gly Phe Thr Lys Cys Pro Lys Ile Ser Ser Ile Ser Glu Tyr Ser Asp 
            100                 105                 110         


Gly Asn Thr Val Asn Ala Arg Leu Ser Ser Val Ser Pro Gly Gln Gly 
        115                 120                 125             


Lys Asp Ser Pro Ala Ile Thr Arg Glu Glu Ala Leu Ser Met Ile Lys 
    130                 135                 140                 


Asp Cys Glu Met Ser Ile Asn Ile Lys Cys Ser Glu Glu Glu Lys Asp 
145                 150                 155                 160 


Ser Asn Ile Lys Thr His Pro Val Leu Gly Ser Asn Ile Ser His Lys 
                165                 170                 175     


Lys Val Ser Tyr Glu Asp Ile Ile Gly Ser Thr Ile Val Asp Thr Lys 
            180                 185                 190         


Cys Val Lys Asn Leu Glu Ile Ser Val Arg Ile Gly Asp Met Cys Lys 
        195                 200                 205             


Glu Ser Ser Glu Leu Glu Val Lys Asp Gly Phe Lys Tyr Val Asp Gly 
    210                 215                 220                 


Ser Ala Ser Glu Asp Ala Ala Asp Asp Thr Ser Leu Ile Asn Ser Ala 
225                 230                 235                 240 


Lys Leu Ile Ala Cys Val 
                245     


