                         SEQUENCE LISTING

<110>  CuRNA, Inc.
 
<120>  TREATMENT OF ATP-BINDING CASSETTE SUB-FAMILY B MEMBER 1 (ABCB1) 
       RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO
        ABCB1

<130>  ABCB1

<150>  US61/237,871
<151>  2009-08-28

<160>  11    

<170>  PatentIn version 3.5

<210>  1
<211>  4872
<212>  DNA
<213>  Homo sapiens

<300>
<308>  NM_000927
<309>  2010-08-03
<313>  (1)..(4872)

<400>  1
tattcagata ttctccagat tcctaaagat tagagatcat ttctcattct cctaggagta       60

ctcacttcag gaagcaacca gataaaagag aggtgcaacg gaagccagaa cattcctcct      120

ggaaattcaa cctgtttcgc agtttctcga ggaatcagca ttcagtcaat ccgggccggg      180

agcagtcatc tgtggtgagg ctgattggct gggcaggaac agcgccgggg cgtgggctga      240

gcacagccgc ttcgctctct ttgccacagg aagcctgagc tcattcgagt agcggctctt      300

ccaagctcaa agaagcagag gccgctgttc gtttccttta ggtctttcca ctaaagtcgg      360

agtatcttct tccaaaattt cacgtcttgg tggccgttcc aaggagcgcg aggtcggaat      420

ggatcttgaa ggggaccgca atggaggagc aaagaagaag aactttttta aactgaacaa      480

taaaagtgaa aaagataaga aggaaaagaa accaactgtc agtgtatttt caatgtttcg      540

ctattcaaat tggcttgaca agttgtatat ggtggtggga actttggctg ccatcatcca      600

tggggctgga cttcctctca tgatgctggt gtttggagaa atgacagata tctttgcaaa      660

tgcaggaaat ttagaagatc tgatgtcaaa catcactaat agaagtgata tcaatgatac      720

agggttcttc atgaatctgg aggaagacat gaccaggtat gcctattatt acagtggaat      780

tggtgctggg gtgctggttg ctgcttacat tcaggtttca ttttggtgcc tggcagctgg      840

aagacaaata cacaaaatta gaaaacagtt ttttcatgct ataatgcgac aggagatagg      900

ctggtttgat gtgcacgatg ttggggagct taacacccga cttacagatg atgtctccaa      960

gattaatgaa ggaattggtg acaaaattgg aatgttcttt cagtcaatgg caacattttt     1020

cactgggttt atagtaggat ttacacgtgg ttggaagcta acccttgtga ttttggccat     1080

cagtcctgtt cttggactgt cagctgctgt ctgggcaaag atactatctt catttactga     1140

taaagaactc ttagcgtatg caaaagctgg agcagtagct gaagaggtct tggcagcaat     1200

tagaactgtg attgcatttg gaggacaaaa gaaagaactt gaaaggtaca acaaaaattt     1260

agaagaagct aaaagaattg ggataaagaa agctattaca gccaatattt ctataggtgc     1320

tgctttcctg ctgatctatg catcttatgc tctggccttc tggtatggga ccaccttggt     1380

cctctcaggg gaatattcta ttggacaagt actcactgta ttcttttctg tattaattgg     1440

ggcttttagt gttggacagg catctccaag cattgaagca tttgcaaatg caagaggagc     1500

agcttatgaa atcttcaaga taattgataa taagccaagt attgacagct attcgaagag     1560

tgggcacaaa ccagataata ttaagggaaa tttggaattc agaaatgttc acttcagtta     1620

cccatctcga aaagaagtta agatcttgaa gggtctgaac ctgaaggtgc agagtgggca     1680

gacggtggcc ctggttggaa acagtggctg tgggaagagc acaacagtcc agctgatgca     1740

gaggctctat gaccccacag aggggatggt cagtgttgat ggacaggata ttaggaccat     1800

aaatgtaagg tttctacggg aaatcattgg tgtggtgagt caggaacctg tattgtttgc     1860

caccacgata gctgaaaaca ttcgctatgg ccgtgaaaat gtcaccatgg atgagattga     1920

gaaagctgtc aaggaagcca atgcctatga ctttatcatg aaactgcctc ataaatttga     1980

caccctggtt ggagagagag gggcccagtt gagtggtggg cagaagcaga ggatcgccat     2040

tgcacgtgcc ctggttcgca accccaagat cctcctgctg gatgaggcca cgtcagcctt     2100

ggacacagaa agcgaagcag tggttcaggt ggctctggat aaggccagaa aaggtcggac     2160

caccattgtg atagctcatc gtttgtctac agttcgtaat gctgacgtca tcgctggttt     2220

cgatgatgga gtcattgtgg agaaaggaaa tcatgatgaa ctcatgaaag agaaaggcat     2280

ttacttcaaa cttgtcacaa tgcagacagc aggaaatgaa gttgaattag aaaatgcagc     2340

tgatgaatcc aaaagtgaaa ttgatgcctt ggaaatgtct tcaaatgatt caagatccag     2400

tctaataaga aaaagatcaa ctcgtaggag tgtccgtgga tcacaagccc aagacagaaa     2460

gcttagtacc aaagaggctc tggatgaaag tatacctcca gtttcctttt ggaggattat     2520

gaagctaaat ttaactgaat ggccttattt tgttgttggt gtattttgtg ccattataaa     2580

tggaggcctg caaccagcat ttgcaataat attttcaaag attatagggg tttttacaag     2640

aattgatgat cctgaaacaa aacgacagaa tagtaacttg ttttcactat tgtttctagc     2700

ccttggaatt atttctttta ttacattttt ccttcagggt ttcacatttg gcaaagctgg     2760

agagatcctc accaagcggc tccgatacat ggttttccga tccatgctca gacaggatgt     2820

gagttggttt gatgacccta aaaacaccac tggagcattg actaccaggc tcgccaatga     2880

tgctgctcaa gttaaagggg ctataggttc caggcttgct gtaattaccc agaatatagc     2940

aaatcttggg acaggaataa ttatatcctt catctatggt tggcaactaa cactgttact     3000

cttagcaatt gtacccatca ttgcaatagc aggagttgtt gaaatgaaaa tgttgtctgg     3060

acaagcactg aaagataaga aagaactaga aggttctggg aagatcgcta ctgaagcaat     3120

agaaaacttc cgaaccgttg tttctttgac tcaggagcag aagtttgaac atatgtatgc     3180

tcagagtttg caggtaccat acagaaactc tttgaggaaa gcacacatct ttggaattac     3240

attttccttc acccaggcaa tgatgtattt ttcctatgct ggatgtttcc ggtttggagc     3300

ctacttggtg gcacataaac tcatgagctt tgaggatgtt ctgttagtat tttcagctgt     3360

tgtctttggt gccatggccg tggggcaagt cagttcattt gctcctgact atgccaaagc     3420

caaaatatca gcagcccaca tcatcatgat cattgaaaaa acccctttga ttgacagcta     3480

cagcacggaa ggcctaatgc cgaacacatt ggaaggaaat gtcacatttg gtgaagttgt     3540

attcaactat cccacccgac cggacatccc agtgcttcag ggactgagcc tggaggtgaa     3600

gaagggccag acgctggctc tggtgggcag cagtggctgt gggaagagca cagtggtcca     3660

gctcctggag cggttctacg accccttggc agggaaagtg ctgcttgatg gcaaagaaat     3720

aaagcgactg aatgttcagt ggctccgagc acacctgggc atcgtgtccc aggagcccat     3780

cctgtttgac tgcagcattg ctgagaacat tgcctatgga gacaacagcc gggtggtgtc     3840

acaggaagag attgtgaggg cagcaaagga ggccaacata catgccttca tcgagtcact     3900

gcctaataaa tatagcacta aagtaggaga caaaggaact cagctctctg gtggccagaa     3960

acaacgcatt gccatagctc gtgcccttgt tagacagcct catattttgc ttttggatga     4020

agccacgtca gctctggata cagaaagtga aaaggttgtc caagaagccc tggacaaagc     4080

cagagaaggc cgcacctgca ttgtgattgc tcaccgcctg tccaccatcc agaatgcaga     4140

cttaatagtg gtgtttcaga atggcagagt caaggagcat ggcacgcatc agcagctgct     4200

ggcacagaaa ggcatctatt tttcaatggt cagtgtccag gctggaacaa agcgccagtg     4260

aactctgact gtatgagatg ttaaatactt tttaatattt gtttagatat gacatttatt     4320

caaagttaaa agcaaacact tacagaatta tgaagaggta tctgtttaac atttcctcag     4380

tcaagttcag agtcttcaga gacttcgtaa ttaaaggaac agagtgagag acatcatcaa     4440

gtggagagaa atcatagttt aaactgcatt ataaatttta taacagaatt aaagtagatt     4500

ttaaaagata aaatgtgtaa ttttgtttat attttcccat ttggactgta actgactgcc     4560

ttgctaaaag attatagaag tagcaaaaag tattgaaatg tttgcataaa gtgtctataa     4620

taaaactaaa ctttcatgtg actggagtca tcttgtccaa actgcctgtg aatatatctt     4680

ctctcaattg gaatattgta gataacttct gctttaaaaa agttttcttt aaatatacct     4740

actcattttt gtgggaatgg ttaagcagtt taaataattc ctgttgtata tgtctattca     4800

cattgggtct tacagaacca tctggcttca ttcttcttgg acttgatcct gctgattctt     4860

gcatttccac at                                                         4872


<210>  2
<211>  4050
<212>  DNA
<213>  Homo sapiens

<400>  2
gctggggcac gagtggctgc ggagtgtggg tggttgggcg tgaggggccg acgggctcgc       60

gcgcgcgccg tctgctgagg tccctcggga aggaggagag cgcctgacgc cgacccgcag      120

gcgcagcccg gcagtcggcg gcgcgccgag ggcggaggtg gtgcgtgcgt gcgtgtgtgt      180

gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt gtggagctcg ggtgccaagg gcgagccgtc      240

agtccccggg tgcgagtccc tgctgtcttc cacacccttc ctccctccag gctcctttcc      300

tacatccttc ccgcgccccc acggttgcgg accgagcgag aaccccctta agcaggtgtg      360

gggggcgtgc ggggtggcac gagacaaaag gggcacgggg gtaagcccgc catggcctcc      420

cggagcctgg ggggcctgag cgggatccgc ggcggtggcg gcggaggcgg caagaaaagc      480

ctgagcgccc gcaatgctgc ggtggagagg aggaacctga tcaccgtgtg caggttttct      540

gtgaagaccc tgattgatcg gtcttgcttt gagacaattg atgattcttc tcctgaattt      600

aacaattttg cagctatttt ggaacagatt ttaagccacc ggctaaaagg tcaagtaacc      660

tggtttggtt atgaaagtcc tcgtagcttc tgggactata tcagagtggc ttgccggaaa      720

gtttcacaga attgtatctg cagcattgaa aatatggaaa atgtcagttc ttctagagct      780

aagggtagag cctggatcag agtagcactc atggaaaaac atttatctga atacatctct      840

acagctctga gagacttcaa aacaaccagg agattttatg aagatggagc aattgtcttg      900

ggtgaagaag caaatatgct tgctggcatg cttctaggac tcaatgctat tgatttcagt      960

ttctgcctaa agggagaggg gctggatggc agttttcctg ctgtaataga ctatacacca     1020

tatttgaagt atatccaaag ttctgatagt atcagcagtg atgaggagga gctaaggact     1080

ttgggaagca gtggtagcga aagcagtact ccagagaatg tcggacctcc tttcctcatg     1140

gatgagaaca gttggttcaa caagtgtaag agagttaaac aaaagtatca gcttaccctg     1200

gaacagaagg gttaccttga agaactctta cgacttcgag agaaccaact atctgaatct     1260

gtctcccaga ataaaatact acttcaaagg attgaagatt ccgatctggc tcataaactg     1320

gagaaggaac aattagaata tataattgtg gagcttcaag atcagctgac tgtgctaaag     1380

aataatgatt taagatcgag acaagagtta actgcccatc tcaccaacca gtggccttct     1440

ccaggagctc tggatgtcaa tgctgttgcc ttggatacgt tgctttaccg aaaacacaat     1500

aaacagtggt atgagaaaag ttatcaaagt cttgaccagt tatcagcaga agttagcctt     1560

tctcagactt cactagatcc aggccagtca caagaaggag atggaaaaca agacacatta     1620

aatgtaatga gtgaaggtaa ggaagatact ccctcattac ttggcctctg tggatctcta     1680

acgtcagtgg caagttacaa gtctctaaca agcttaaaat ctaatgacta ccttgcaagt     1740

cctacaacag agatgacaag tccaggccta actccatcct gaaaattttt gtgtaaaagc     1800

caaaactttt tatgttgtaa atgtttaatt tacatgtttg actgctggga agacctttga     1860

aattttatat tgttctggta catgtctgaa attctattgc ttggagagaa tcccctccag     1920

ataagagatt ttgagtgaaa aacataatga tcctgccatt tttcattttt aaaattctta     1980

catttgtcat tgagaaagtt caaaatggaa taggctttaa aaaaaaaaaa actttcaaag     2040

atccgccaaa tcattcatag caaattgtac atattgttca gctgattttt atatatttaa     2100

atacacctta gtggccagag actgacttca aggttttatt ccagagactc cagagactta     2160

agctaagtat tttttcattc tttcagattt tcaaaaaaaa aaaaaaaaaa agttaatttc     2220

attttttcat taatgtcttc ctaagttcta tgctttaaat gccttgtttt taataacggg     2280

aaagttctca gctgcatttt cacagtggct tattcagttt ttctttaata tttaccattt     2340

ggtatcaatt cagcattcca cttaacattt tataaattcc ataggaacat gcctgttttg     2400

gtagttactg acttaatttg ttagtgccac aaggaaaata ttttacagta ttttatgcca     2460

tttaggcaaa atgaataaac tgttttccaa gattttctta aaagattatc aatttaaaag     2520

tatgatcaag tatgcctcaa aaactagaaa catttcaaaa tgtagaacaa acgttgaaaa     2580

attgttttgc caggaaagag ttcaagttca gttaaggatt tgagaggctt ttaaacaagg     2640

atcagtagga tagttatcat atttacttaa tatatgtctg atattcagtg ctggttcttt     2700

ttcctgtttg tgcaacaatg aagtgtgtca tgtgtgtttt atagcctcta tcattaatca     2760

caccagagtc tcattttaaa acattttaat gttaaaacat ccccacactt atacacaggt     2820

aaaattagtt tttttttttt taaagttgta atctgtactt tttttttttt gcaatttttg     2880

aaacagctac attaatccct aaaaatccca ccatactgaa aatgtatggc gtgtattttc     2940

tatagtaagt aatatgagga aaacatgatt agctgtgcca aagaaatttt atacattgtt     3000

tacatgatga ggccacagta cttactgagg acttcatatg gtttttttgt ttattattat     3060

tgagaaaaga gctgaggtta ccacattcat tctttgtgtt agaaatgtag gagtgtggtg     3120

gttttctgca atatttagag cttagtctca taatttggaa tttaagataa taagtagtaa     3180

caaggcaagt cttttatgta agacagtcaa acagtgtcac ttcagggaca aaggcctgga     3240

agcccttaaa ataagttatc ttagatgtgc cagaacatat tcagagcttt attcctttaa     3300

gcttaaggct tcaatacttg tagaaatgca aatattcttg agaaatgata cattttttgt     3360

tctcaatttc tcaattctac atacctgatt atgagtgaag tatccaaagc aggttttcat     3420

cagcatgggg gatggaaggt aggtataata tgaggacaat ggaaactttg ggagaaggga     3480

gtgaggaaat ggataaagag aaatttgaaa attttaggct ggacttgagc actattgctg     3540

ctttcctatg aactatcaga atgtttaaat gctttatcat tcatggtcca ctctcaacca     3600

acatttatta tcctttagta attaaacaat ggttttacat acatttttat aatgtagaag     3660

gaaattcaag attccataat cgtaaaattt ttcagatttg tctaatgtgt aatttgtgca     3720

tcttcacatg ctgctaaatg cagatttaaa cattacatct gaggatcatg acttttcctc     3780

ctttcttgga gatcttggta taaaattcat ctgctgttat aaaatcaggt ttctacagag     3840

ttcgtttcac actaaaggta gtttgttact gtttgcatga ggaaaccatg tatgtctcaa     3900

tctttaattt taggtggtag tgtttattgt tcaccctccc tcttgcctcc aaaagaatgc     3960

tgaattatac gccaatattt ccatgtgtat tctgttgcct tgatgcgtac tatacttgtt     4020

gcatgtatat taaaaatttt gtactatgca                                      4050


<210>  3
<211>  1334
<212>  DNA
<213>  Homo sapiens

<400>  3
gctgggtccc ttccgccctg gcgcgctcct ccaccagccc gcggctgcga gctgggcagc       60

gagatccaca gcacagggct ggcgcggaaa acaccgtcct gaaggctgct gctgcgggtg      120

ctcttggagc gacttgtggc tgtcgccact tggtccccac agactcaaga ggacgctacc      180

acccggaccg gactcaggca tccggagcac cgcactcttc cgagaactgc ctacctcacg      240

tgccacctcc gggtttcctt cgcaaagtca gccaagatgt agaatttgga agtagctctg      300

agttgagcgg aacctcagaa gatggaagca gcggcctcag cctcttacgg cttcaagagc      360

cactgcggga aggagccaga gggcttcctc gggccccgga ttaaaataga tgccagcggc      420

cgccctaagg cccggcagcc aatcagcctg gtgggtggga ttgggcatgg gcagctggag      480

cggttgcgaa acaggagata cttccaggct taccctgatt tttttgagaa gggcgctggt      540

tccctcagac atttacatag acttgtcttt acgtgttcag tgggcagtgt gttcacaccg      600

ggattgaagt cgctcaactg tgaaatgaca tgggaacgtt ccagtgtgtt cacaccagga      660

ttgaagtcaa taaactgtga agtgacatgg gaacgttcaa tggcctcaca cctcggagtc      720

tcaatcctta ctgatttgat cccctgaatc cacaggtgca agagagagcc aactcctgaa      780

agttgtcctg tgacatccac acttgcaaca tgacataggg tacatgtgga tgccagaaga      840

caaacagatg tcttttctca ggagctgtcc atcttgtttt ctgacagttg ttctttgtta      900

actagggctc actgtgtagg caagtctggc tggccagcat ctatctctct ctacctccca      960

gtactgggat tataagcacc cccctcatac cctgactttt tatgtggatg ctgaggactg     1020

aatcaaattc ttattcttgt tgggcaagca cattaccaac tgaactgaat ctccccggct     1080

cctactggta cttcttaatg catattaatg aaccaactaa tgggtttcac tgtagaatag     1140

atagatagat agatagatag atagatagat agatagatag atagatagat taattataca     1200

tagaaatcac acacacacac acacacacac acacttcctg cagtgtttat gctgaccatc     1260

acctctcttt tcccaaccac cattccctta cctttcctcc ccttccaacc actaataaac     1320

ccctttcttc tgtt                                                       1334


<210>  4
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  4
ttcctcactc ccttctccca                                                   20


<210>  5
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  5
gccactctga tatagtccca g                                                 21


<210>  6
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  6
ctttcgctac cactgcttcc c                                                 21


<210>  7
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  7
accaccacac tcctacattt c                                                 21


<210>  8
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  8
atgcccaatc ccacccacca                                                   20


<210>  9
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  9
tccttcccgc agtggctctt                                                   20


<210>  10
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  10
gctctctctt gcacctgtgg a                                                 21


<210>  11
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Antisense oligonucleotide

<400>  11
gcgtcctctt gagtctgtgg                                                   20


