                         SEQUENCE LISTING

<110>  Immunotope, Inc.
 
<120>  CYTOTOXIC T-LYMPHOCYTE-INDUCING IMMUNOGENS FOR PREVENTION, 
       TREATMENT,  AND DIAGNOSIS OF CANCER

<130>  2010-1

<160>  172   

<170>  PatentIn version 3.5

<210>  1
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  1

Ala Glu Tyr Asp Asn Phe Phe Gln His Leu 
1               5                   10  


<210>  2
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  2

Ala Leu Ile Leu Glu Pro Ser Leu Tyr Thr Val 
1               5                   10      


<210>  3
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  3

Ala Leu Leu Gly Leu Asp Ala Val Gln Leu 
1               5                   10  


<210>  4
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  4

Asp Asp Val Pro Glu Arg Gly Leu Ile 
1               5                   


<210>  5
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Ile Asn Thr Asp Gly Ala Val Asn Phe 
1               5                   10  


<210>  6
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  6

Asp Leu Asp Pro Glu Ala Val Arg Gly Ala Leu 
1               5                   10      


<210>  7
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  7

Asp Pro Phe Ala Phe Ile His Lys Ile 
1               5                   


<210>  8
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  8

Asp Gln Phe Gln Lys Val Leu Ser Leu 
1               5                   


<210>  9
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  9

Asp Ser Pro Val Gly Leu Ala Ala Tyr Ile Leu 
1               5                   10      


<210>  10
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  10

Asp Val Ile Val Lys Thr Pro Cys Pro Val Val 
1               5                   10      


<210>  11
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  11

Glu Ala Val Arg Ser Asn Leu Thr Leu 
1               5                   


<210>  12
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  12

Glu Ile Asn Thr Val Ser Ile Gln Val Lys 
1               5                   10  


<210>  13
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  13

Glu Leu Asn Glu Ile Leu Glu Glu Ile 
1               5                   


<210>  14
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  14

Glu Met Leu Pro Asn Leu Glu Ile Leu 
1               5                   


<210>  15
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  15

Glu Met Asn Ile Lys Val Pro Lys Ile 
1               5                   


<210>  16
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  16

Glu Val Glu Glu Gly Glu Ser Val Val Leu Pro Cys 
1               5                   10          


<210>  17
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  17

Glu Val Val Asn Asp Leu Asn Thr Leu 
1               5                   


<210>  18
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  18

Phe Leu Leu Asp Gly Phe Pro Arg Thr Val 
1               5                   10  


<210>  19
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  19

Gly Met Tyr Gly Lys Ile Ala Val Met Glu Leu 
1               5                   10      


<210>  20
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  20

His Tyr Val Tyr Ile Ile Asn Val 
1               5               


<210>  21
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  21

Ile Leu Asp Val Ile Asp Asp Thr Ile 
1               5                   


<210>  22
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  22

Ile Leu Thr Thr Ser Val Pro Val Tyr Ser Leu 
1               5                   10      


<210>  23
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  23

Ile Met Pro Val His Leu Leu Met Leu 
1               5                   


<210>  24
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  24

Lys Asp Asn Ile Pro Met Leu Leu 
1               5               


<210>  25
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  25

Lys Ile Phe Lys Glu Glu Gly Leu Leu Gly Phe 
1               5                   10      


<210>  26
<211>  9
<212>  PRT
<213>  herpes simplex virus 7

<400>  26

Lys Ile Lys Thr Leu Leu Asn Glu Leu 
1               5                   


<210>  27
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  27

Lys Ile Leu Met Leu Gln Asn Asn Gln 
1               5                   


<210>  28
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  28

Lys Ile Asn Glu Leu Asn Glu Glu Leu 
1               5                   


<210>  29
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  29

Lys Ile Tyr Gln Trp Ile Asn Glu Leu 
1               5                   


<210>  30
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  30

Lys Leu Ala Asp Met Leu Thr Glu Ile Thr Leu 
1               5                   10      


<210>  31
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  31

Lys Leu Phe Asp Ile Arg Pro Ile Trp 
1               5                   


<210>  32
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  32

Lys Leu Phe Ile Gly Gly Leu Ser Phe 
1               5                   


<210>  33
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  33

Lys Leu Gly Glu Phe Ala Lys Val Leu Glu Leu 
1               5                   10      


<210>  34
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  34

Lys Leu Ile Pro Phe Leu Glu Lys Leu 
1               5                   


<210>  35
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  35

Lys Leu Asn Glu Ile Asn Glu Lys Ile 
1               5                   


<210>  36
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  36

Lys Leu Ser Leu Val Ala Ala Met Leu 
1               5                   


<210>  37
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  37

Lys Leu Thr Ser Thr Val Met Leu Trp 
1               5                   


<210>  38
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  38

Lys Leu Tyr Glu Phe Val His Ser Phe 
1               5                   


<210>  39
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  39

Lys Leu Tyr Pro Trp Ile His Gln Phe 
1               5                   


<210>  40
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  40

Lys Leu Tyr Gln Glu Met Phe Ala Trp 
1               5                   


<210>  41
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  41

Lys Met Phe Ser Asp Glu Ile Leu Leu 
1               5                   


<210>  42
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  42

Lys Met Phe Val Gly Gly Leu Ser Trp 
1               5                   


<210>  43
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  43

Lys Ser Leu Leu Phe Val Asn Thr Leu 
1               5                   


<210>  44
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  44

Leu Thr Ile Lys Ser Ile Ile Thr Leu 
1               5                   


<210>  45
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  45

Leu Thr Leu Leu Asn Pro Arg Met Ile Val 
1               5                   10  


<210>  46
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  46

Leu Val Glu Glu Leu Ser Leu Gln Glu Ala 
1               5                   10  


<210>  47
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  47

Leu Val Phe Gln Thr Cys Asp Ile 
1               5               


<210>  48
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  48

Leu Val Met Ser Asn Gln Lys Glu Val Leu 
1               5                   10  


<210>  49
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  49

Leu Val Ser Ile Val Val Ala Val Pro Leu 
1               5                   10  


<210>  50
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  50

Leu Trp Pro Asp Ile Gly Val Pro Ile 
1               5                   


<210>  51
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  51

Met Asp Arg Val Leu Leu His Val 
1               5               


<210>  52
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  52

Met Glu Ala Ala Met Lys Gly Leu Val Gln Glu 
1               5                   10      


<210>  53
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  53

Met Gly Phe Lys Pro Leu Val Leu 
1               5               


<210>  54
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  54

Met Leu Asp Leu His Cys Asp Lys Ile 
1               5                   


<210>  55
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  55

Met Thr Tyr Asp Gly Asn Asn Pro Val Thr 
1               5                   10  


<210>  56
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  56

Met Val Asp Asn Pro Leu Asn Gln Leu Ser 
1               5                   10  


<210>  57
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  57

Asn Lys Asp Asn Asp Lys Leu Ile 
1               5               


<210>  58
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  58

Asn Lys Glu Val Glu Glu Glu Arg Ile Ala Gly 
1               5                   10      


<210>  59
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  59

Gln Ala Leu Ala Gln Lys Gly Leu Tyr Val Thr 
1               5                   10      


<210>  60
<211>  11
<212>  PRT
<213>  Human papillomavirus type 23

<400>  60

Gln Ile Asn Ala Met Asn Ser Asp Ile Leu Glu 
1               5                   10      


<210>  61
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  61

Gln Ile Asn Glu Gln Val Glu Lys Leu 
1               5                   


<210>  62
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  62

Gln Leu Asp Glu Leu Asn Gln Lys Leu 
1               5                   


<210>  63
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  63

Gln Val His Lys Arg Gly Val Val Glu Tyr Glu Ala 
1               5                   10          


<210>  64
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  64

Arg Ile Ile Lys Trp Leu Tyr Ser Ile 
1               5                   


<210>  65
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  65

Arg Ile Asn Thr Val Ser Leu Lys Glu Ala 
1               5                   10  


<210>  66
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  66

Arg Leu Phe Pro Leu Ser Gly His Leu Leu Leu 
1               5                   10      


<210>  67
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  67

Arg Leu Leu Glu Val Pro Val Met Leu 
1               5                   


<210>  68
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  68

Ser Ile Met Ser Ile Asp Lys Ala Val Thr 
1               5                   10  


<210>  69
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  69

Ser Leu Asp Arg Tyr Ile Lys Ile 
1               5               


<210>  70
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  70

Ser Leu Phe Ala Gly Gly Met Leu Arg Val 
1               5                   10  


<210>  71
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  71

Ser Leu Met Gln Cys Trp Gln Leu 
1               5               


<210>  72
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  72

Ser Leu Val Ala Lys Asp Asn Gly Ser Leu 
1               5                   10  


<210>  73
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  73

Ser Leu Val Leu Arg Lys Leu Asp His Leu 
1               5                   10  


<210>  74
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  74

Ser Pro Ala Leu Ala Leu Pro Asn Leu Ala Asn 
1               5                   10      


<210>  75
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  75

Ser Ser Ser Gly Leu Ile Ser Ser Leu Asn Glu Ile 
1               5                   10          


<210>  76
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  76

Thr Cys Phe Asn Leu Leu Asp Leu 
1               5               


<210>  77
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  77

Thr Leu Thr Val Gly Thr Asn Gly Gly Leu Lys 
1               5                   10      


<210>  78
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  78

Thr Leu Val Gln Leu Pro Asn Gly Gln Thr Val 
1               5                   10      


<210>  79
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  79

Thr Val Phe Val Leu Asp Asp Gly Thr Val 
1               5                   10  


<210>  80
<211>  8
<212>  PRT
<213>  Homo sapiens

<400>  80

Thr Val Met Met Gly Lys Lys Leu 
1               5               


<210>  81
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  81

Val Leu Gly Ala Val Met Ile Val Met Val 
1               5                   10  


<210>  82
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  82

Val Leu Val Pro Val Leu Val Met Val 
1               5                   


<210>  83
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  83

Val Met Leu Pro Asp Asn Gln Ser Leu 
1               5                   


<210>  84
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  84

Tyr Ile Asn Gln Ser Lys Ala Ile Asp Tyr Glu Ala 
1               5                   10          


<210>  85
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  85

Tyr Leu Leu Arg Val Val Leu Lys Thr 
1               5                   


<210>  86
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  86

Tyr Val Glu Phe Thr Arg Ser Leu Phe Val Asn 
1               5                   10      


<210>  87
<211>  1538
<212>  PRT
<213>  Homo sapiens

<400>  87

Met Glu Pro Arg Met Glu Ser Cys Leu Ala Gln Val Leu Gln Lys Asp 
1               5                   10                  15      


Val Gly Lys Arg Leu Gln Val Gly Gln Glu Leu Ile Asp Tyr Phe Ser 
            20                  25                  30          


Asp Lys Gln Lys Ser Ala Asp Leu Glu His Asp Gln Thr Met Leu Asp 
        35                  40                  45              


Lys Leu Val Asp Gly Leu Ala Thr Ser Trp Val Asn Ser Ser Asn Tyr 
    50                  55                  60                  


Lys Val Val Leu Leu Gly Met Asp Ile Leu Ser Ala Leu Val Thr Arg 
65                  70                  75                  80  


Leu Gln Asp Arg Phe Lys Ala Gln Ile Gly Thr Val Leu Pro Ser Leu 
                85                  90                  95      


Ile Asp Arg Leu Gly Asp Ala Lys Asp Ser Val Arg Glu Gln Asp Gln 
            100                 105                 110         


Thr Leu Leu Leu Lys Ile Met Asp Gln Ala Ala Asn Pro Gln Tyr Val 
        115                 120                 125             


Trp Asp Arg Met Leu Gly Gly Phe Lys His Lys Asn Phe Arg Thr Arg 
    130                 135                 140                 


Glu Gly Ile Cys Leu Cys Leu Ile Ala Thr Leu Asn Ala Ser Gly Ala 
145                 150                 155                 160 


Gln Thr Leu Thr Leu Ser Lys Ile Val Pro His Ile Cys Asn Leu Leu 
                165                 170                 175     


Gly Asp Pro Asn Ser Gln Val Arg Asp Ala Ala Ile Asn Ser Leu Val 
            180                 185                 190         


Glu Ile Tyr Arg His Val Gly Glu Arg Val Arg Ala Asp Leu Ser Lys 
        195                 200                 205             


Lys Gly Leu Pro Gln Ser Arg Leu Asn Val Ile Phe Thr Lys Phe Asp 
    210                 215                 220                 


Glu Val Gln Lys Ser Gly Asn Met Ile Gln Ser Ala Asn Asp Lys Asn 
225                 230                 235                 240 


Phe Asp Asp Glu Asp Ser Val Asp Gly Asn Arg Pro Ser Ser Ala Ser 
                245                 250                 255     


Ser Thr Ser Ser Lys Ala Pro Pro Ser Ser Arg Arg Asn Val Gly Met 
            260                 265                 270         


Gly Thr Thr Arg Arg Leu Gly Ser Ser Thr Leu Gly Ser Lys Ser Ser 
        275                 280                 285             


Ala Ala Lys Glu Gly Ala Gly Ala Val Asp Glu Glu Asp Phe Ile Lys 
    290                 295                 300                 


Ala Phe Asp Asp Val Pro Val Val Gln Ile Tyr Ser Ser Arg Asp Leu 
305                 310                 315                 320 


Glu Glu Ser Ile Asn Lys Ile Arg Glu Ile Leu Ser Asp Asp Lys His 
                325                 330                 335     


Asp Trp Glu Gln Arg Val Asn Ala Leu Lys Lys Ile Arg Ser Leu Leu 
            340                 345                 350         


Leu Ala Gly Ala Ala Glu Tyr Asp Asn Phe Phe Gln His Leu Arg Leu 
        355                 360                 365             


Leu Asp Gly Ala Phe Lys Leu Ser Ala Lys Asp Leu Arg Ser Gln Val 
    370                 375                 380                 


Val Arg Glu Ala Cys Ile Thr Leu Gly His Leu Ser Ser Val Leu Gly 
385                 390                 395                 400 


Asn Lys Phe Asp His Gly Ala Glu Ala Ile Met Pro Thr Ile Phe Asn 
                405                 410                 415     


Leu Ile Pro Asn Ser Ala Lys Ile Met Ala Thr Ser Gly Val Val Ala 
            420                 425                 430         


Val Arg Leu Ile Ile Arg His Thr His Ile Pro Arg Leu Ile Pro Val 
        435                 440                 445             


Ile Thr Ser Asn Cys Thr Ser Lys Ser Val Ala Val Arg Arg Arg Cys 
    450                 455                 460                 


Phe Glu Phe Leu Asp Leu Leu Leu Gln Glu Trp Gln Thr His Ser Leu 
465                 470                 475                 480 


Glu Arg His Ile Ser Val Leu Ala Glu Thr Ile Lys Lys Gly Ile His 
                485                 490                 495     


Asp Ala Asp Ser Glu Ala Arg Ile Glu Ala Arg Lys Cys Tyr Trp Gly 
            500                 505                 510         


Phe His Ser His Phe Ser Arg Glu Ala Glu His Leu Tyr His Thr Leu 
        515                 520                 525             


Glu Ser Ser Tyr Gln Lys Ala Leu Gln Ser His Leu Lys Asn Ser Asp 
    530                 535                 540                 


Ser Ile Val Ser Leu Pro Gln Ser Asp Arg Ser Ser Ser Ser Ser Gln 
545                 550                 555                 560 


Glu Ser Leu Asn Arg Pro Leu Ser Ala Lys Arg Ser Pro Thr Gly Ser 
                565                 570                 575     


Thr Thr Ser Arg Ala Ser Thr Val Ser Thr Lys Ser Val Ser Thr Thr 
            580                 585                 590         


Gly Ser Leu Gln Arg Ser Arg Ser Asp Ile Asp Val Asn Ala Ala Ala 
        595                 600                 605             


Ser Ala Lys Ser Lys Val Ser Ser Ser Ser Gly Thr Thr Pro Phe Ser 
    610                 615                 620                 


Ser Ala Ala Ala Leu Pro Pro Gly Ser Tyr Ala Ser Leu Gly Arg Ile 
625                 630                 635                 640 


Arg Thr Arg Arg Gln Ser Ser Gly Ser Ala Thr Asn Val Ala Ser Thr 
                645                 650                 655     


Pro Asp Asn Arg Gly Arg Ser Arg Ala Lys Val Val Ser Gln Ser Gln 
            660                 665                 670         


Arg Ser Arg Ser Ala Asn Pro Ala Gly Ala Gly Ser Arg Ser Ser Ser 
        675                 680                 685             


Pro Gly Lys Leu Leu Gly Ser Gly Tyr Gly Gly Leu Thr Gly Gly Ser 
    690                 695                 700                 


Ser Arg Gly Pro Pro Val Thr Pro Ser Ser Glu Lys Arg Ser Lys Ile 
705                 710                 715                 720 


Pro Arg Ser Gln Gly Cys Ser Arg Glu Thr Ser Pro Asn Arg Ile Gly 
                725                 730                 735     


Leu Ala Arg Ser Ser Arg Ile Pro Arg Pro Ser Met Ser Gln Gly Cys 
            740                 745                 750         


Ser Arg Asp Thr Ser Arg Glu Ser Ser Arg Asp Thr Ser Pro Ala Arg 
        755                 760                 765             


Gly Phe Pro Pro Leu Asp Arg Phe Gly Leu Gly Gln Pro Gly Arg Ile 
    770                 775                 780                 


Pro Gly Ser Val Asn Ala Met Arg Val Leu Ser Thr Ser Thr Asp Leu 
785                 790                 795                 800 


Glu Ala Ala Val Ala Asp Ala Leu Lys Lys Pro Val Arg Arg Arg Tyr 
                805                 810                 815     


Glu Pro Tyr Gly Met Tyr Ser Asp Asp Asp Ala Asn Ser Asp Ala Ser 
            820                 825                 830         


Ser Val Cys Ser Glu Arg Ser Tyr Gly Ser Arg Asn Gly Gly Ile Pro 
        835                 840                 845             


His Tyr Leu Arg Gln Thr Glu Asp Val Ala Glu Val Leu Asn His Cys 
    850                 855                 860                 


Ala Ser Ser Asn Trp Ser Glu Arg Lys Glu Gly Leu Leu Gly Leu Gln 
865                 870                 875                 880 


Asn Leu Leu Lys Ser Gln Arg Thr Leu Ser Arg Val Glu Leu Lys Arg 
                885                 890                 895     


Leu Cys Glu Ile Phe Thr Arg Met Phe Ala Asp Pro His Ser Lys Arg 
            900                 905                 910         


Val Phe Ser Met Phe Leu Glu Thr Leu Val Asp Phe Ile Ile Ile His 
        915                 920                 925             


Lys Asp Asp Leu Gln Asp Trp Leu Phe Val Leu Leu Thr Gln Leu Leu 
    930                 935                 940                 


Lys Lys Met Gly Ala Asp Leu Leu Gly Ser Val Gln Ala Lys Val Gln 
945                 950                 955                 960 


Lys Ala Leu Asp Val Thr Arg Asp Ser Phe Pro Phe Asp Gln Gln Phe 
                965                 970                 975     


Asn Ile Leu Met Arg Phe Ile Val Asp Gln Thr Gln Thr Pro Asn Leu 
            980                 985                 990         


Lys Val Lys Val Ala Ile Leu Lys  Tyr Ile Glu Ser Leu  Ala Arg Gln 
        995                 1000                 1005             


Met Asp  Pro Thr Asp Phe Val  Asn Ser Ser Glu Thr  Arg Leu Ala 
    1010                 1015                 1020             


Val Ser  Arg Ile Ile Thr Trp  Thr Thr Glu Pro Lys  Ser Ser Asp 
    1025                 1030                 1035             


Val Arg  Lys Ala Ala Gln Ile  Val Leu Ile Ser Leu  Phe Glu Leu 
    1040                 1045                 1050             


Asn Thr  Pro Glu Phe Thr Met  Leu Leu Gly Ala Leu  Pro Lys Thr 
    1055                 1060                 1065             


Phe Gln  Asp Gly Ala Thr Lys  Leu Leu His Asn His  Leu Lys Asn 
    1070                 1075                 1080             


Ser Ser  Asn Thr Ser Val Gly  Ser Pro Ser Asn Thr  Ile Gly Arg 
    1085                 1090                 1095             


Thr Pro  Ser Arg His Thr Ser  Ser Arg Thr Ser Pro  Leu Thr Ser 
    1100                 1105                 1110             


Pro Thr  Asn Cys Ser His Gly  Gly Leu Ser Pro Ser  Arg Leu Trp 
    1115                 1120                 1125             


Gly Trp  Ser Ala Asp Gly Leu  Ala Lys His Pro Pro  Pro Phe Ser 
    1130                 1135                 1140             


Gln Pro  Asn Ser Ile Pro Thr  Ala Pro Ser His Lys  Ala Leu Arg 
    1145                 1150                 1155             


Arg Ser  Tyr Ser Pro Ser Met  Leu Asp Tyr Asp Thr  Glu Asn Leu 
    1160                 1165                 1170             


Asn Ser  Glu Glu Ile Tyr Ser  Ser Leu Arg Gly Val  Thr Glu Ala 
    1175                 1180                 1185             


Ile Glu  Lys Phe Ser Phe Arg  Ser Gln Glu Asp Leu  Asn Glu Pro 
    1190                 1195                 1200             


Ile Lys  Arg Asp Gly Lys Lys  Glu Cys Asp Ile Val  Ser Arg Asp 
    1205                 1210                 1215             


Gly Gly  Ala Ala Ser Pro Ala  Thr Glu Gly Arg Gly  Gly Ser Glu 
    1220                 1225                 1230             


Val Glu  Gly Gly Arg Thr Ala  Leu Asp Asn Lys Thr  Ser Leu Leu 
    1235                 1240                 1245             


Asn Thr  Gln Pro Pro Arg Ala  Phe Pro Gly Pro Arg  Ala Arg Asp 
    1250                 1255                 1260             


Tyr Asn  Pro Tyr Pro Tyr Ser  Asp Ala Ile Asn Thr  Tyr Asp Lys 
    1265                 1270                 1275             


Thr Ala  Leu Lys Glu Ala Val  Phe Asp Asp Asp Met  Glu Gln Leu 
    1280                 1285                 1290             


Arg Asp  Val Pro Ile Asp His  Ser Asp Leu Val Ala  Asp Leu Leu 
    1295                 1300                 1305             


Lys Glu  Leu Ser Asn His Asn  Glu Arg Val Glu Glu  Arg Lys Gly 
    1310                 1315                 1320             


Ala Leu  Leu Glu Leu Leu Lys  Ile Thr Arg Glu Asp  Ser Leu Gly 
    1325                 1330                 1335             


Val Trp  Glu Glu His Phe Lys  Thr Ile Leu Leu Leu  Leu Leu Glu 
    1340                 1345                 1350             


Thr Leu  Gly Asp Lys Asp His  Ser Ile Arg Ala Leu  Ala Leu Arg 
    1355                 1360                 1365             


Val Leu  Arg Glu Ile Leu Arg  Asn Gln Pro Ala Arg  Phe Lys Asn 
    1370                 1375                 1380             


Tyr Ala  Glu Leu Thr Ile Met  Lys Thr Leu Glu Ala  His Lys Asp 
    1385                 1390                 1395             


Ser His  Lys Glu Val Val Arg  Ala Ala Glu Glu Ala  Ala Ser Thr 
    1400                 1405                 1410             


Leu Ala  Ser Ser Ile His Pro  Glu Gln Cys Ile Lys  Val Leu Cys 
    1415                 1420                 1425             


Pro Ile  Ile Gln Thr Ala Asp  Tyr Pro Ile Asn Leu  Ala Ala Ile 
    1430                 1435                 1440             


Lys Met  Gln Thr Lys Val Val  Glu Arg Ile Ala Lys  Glu Ser Leu 
    1445                 1450                 1455             


Leu Gln  Leu Leu Val Asp Ile  Ile Pro Gly Leu Leu  Gln Gly Tyr 
    1460                 1465                 1470             


Asp Asn  Thr Glu Ser Ser Val  Arg Lys Ala Ser Val  Phe Cys Leu 
    1475                 1480                 1485             


Val Ala  Ile Tyr Ser Val Ile  Gly Glu Asp Leu Lys  Pro His Leu 
    1490                 1495                 1500             


Ala Gln  Leu Thr Gly Ser Lys  Met Lys Leu Leu Asn  Leu Tyr Ile 
    1505                 1510                 1515             


Lys Arg  Ala Gln Thr Thr Asn  Ser Asn Ser Ser Ser  Ser Ser Asp 
    1520                 1525                 1530             


Val Ser  Thr His Ser 
    1535             


<210>  88
<211>  177
<212>  PRT
<213>  Homo sapiens

<400>  88

Met Glu Ala Leu Ile Leu Glu Pro Ser Leu Tyr Thr Val Lys Ala Ile 
1               5                   10                  15      


Leu Ile Leu Asp Asn Asp Gly Asp Arg Leu Phe Ala Lys Tyr Tyr Asp 
            20                  25                  30          


Asp Thr Tyr Pro Ser Val Lys Glu Gln Lys Ala Phe Glu Lys Asn Ile 
        35                  40                  45              


Phe Asn Lys Thr His Arg Thr Asp Ser Glu Ile Ala Leu Leu Glu Gly 
    50                  55                  60                  


Leu Thr Val Val Tyr Lys Ser Ser Ile Asp Leu Tyr Phe Tyr Val Ile 
65                  70                  75                  80  


Gly Ser Ser Tyr Glu Asn Glu Leu Met Leu Met Ala Val Leu Asn Cys 
                85                  90                  95      


Leu Phe Asp Ser Leu Ser Gln Met Leu Arg Lys Asn Val Glu Lys Arg 
            100                 105                 110         


Ala Leu Leu Glu Asn Met Glu Gly Leu Phe Leu Ala Val Asp Glu Ile 
        115                 120                 125             


Val Asp Gly Gly Val Ile Leu Glu Ser Asp Pro Gln Gln Val Val His 
    130                 135                 140                 


Arg Val Ala Leu Arg Gly Glu Asp Val Pro Leu Thr Glu Gln Thr Val 
145                 150                 155                 160 


Ser Gln Val Leu Gln Ser Ala Lys Glu Gln Ile Lys Trp Ser Leu Leu 
                165                 170                 175     


Arg 
    


<210>  89
<211>  1403
<212>  PRT
<213>  Homo sapiens

<400>  89

Met Ala Thr Gln Gln Lys Ala Ser Asp Glu Arg Ile Ser Gln Phe Asp 
1               5                   10                  15      


His Asn Leu Leu Pro Glu Leu Ser Ala Leu Leu Gly Leu Asp Ala Val 
            20                  25                  30          


Gln Leu Ala Lys Glu Leu Glu Glu Glu Glu Gln Lys Glu Arg Ala Lys 
        35                  40                  45              


Met Gln Lys Gly Tyr Asn Ser Gln Met Arg Ser Glu Ala Lys Arg Leu 
    50                  55                  60                  


Lys Thr Phe Val Thr Tyr Glu Pro Tyr Ser Ser Trp Ile Pro Gln Glu 
65                  70                  75                  80  


Met Ala Ala Ala Gly Phe Tyr Phe Thr Gly Val Lys Ser Gly Ile Gln 
                85                  90                  95      


Cys Phe Cys Cys Ser Leu Ile Leu Phe Gly Ala Gly Leu Thr Arg Leu 
            100                 105                 110         


Pro Ile Glu Asp His Lys Arg Phe His Pro Asp Cys Gly Phe Leu Leu 
        115                 120                 125             


Asn Lys Asp Val Gly Asn Ile Ala Lys Tyr Asp Ile Arg Val Lys Asn 
    130                 135                 140                 


Leu Lys Ser Arg Leu Arg Gly Gly Lys Met Arg Tyr Gln Glu Glu Glu 
145                 150                 155                 160 


Ala Arg Leu Ala Ser Phe Arg Asn Trp Pro Phe Tyr Val Gln Gly Ile 
                165                 170                 175     


Ser Pro Cys Val Leu Ser Glu Ala Gly Phe Val Phe Thr Gly Lys Gln 
            180                 185                 190         


Asp Thr Val Gln Cys Phe Ser Cys Gly Gly Cys Leu Gly Asn Trp Glu 
        195                 200                 205             


Glu Gly Asp Asp Pro Trp Lys Glu His Ala Lys Trp Phe Pro Lys Cys 
    210                 215                 220                 


Glu Phe Leu Arg Ser Lys Lys Ser Ser Glu Glu Ile Thr Gln Tyr Ile 
225                 230                 235                 240 


Gln Ser Tyr Lys Gly Phe Val Asp Ile Thr Gly Glu His Phe Val Asn 
                245                 250                 255     


Ser Trp Val Gln Arg Glu Leu Pro Met Ala Ser Ala Tyr Cys Asn Asp 
            260                 265                 270         


Ser Ile Phe Ala Tyr Glu Glu Leu Arg Leu Asp Ser Phe Lys Asp Trp 
        275                 280                 285             


Pro Arg Glu Ser Ala Val Gly Val Ala Ala Leu Ala Lys Ala Gly Leu 
    290                 295                 300                 


Phe Tyr Thr Gly Ile Lys Asp Ile Val Gln Cys Phe Ser Cys Gly Gly 
305                 310                 315                 320 


Cys Leu Glu Lys Trp Gln Glu Gly Asp Asp Pro Leu Asp Asp His Thr 
                325                 330                 335     


Arg Cys Phe Pro Asn Cys Pro Phe Leu Gln Asn Met Lys Ser Ser Ala 
            340                 345                 350         


Glu Val Thr Pro Asp Leu Gln Ser Arg Gly Glu Leu Cys Glu Leu Leu 
        355                 360                 365             


Glu Thr Thr Ser Glu Ser Asn Leu Glu Asp Ser Ile Ala Val Gly Pro 
    370                 375                 380                 


Ile Val Pro Glu Met Ala Gln Gly Glu Ala Gln Trp Phe Gln Glu Ala 
385                 390                 395                 400 


Lys Asn Leu Asn Glu Gln Leu Arg Ala Ala Tyr Thr Ser Ala Ser Phe 
                405                 410                 415     


Arg His Met Ser Leu Leu Asp Ile Ser Ser Asp Leu Ala Thr Asp His 
            420                 425                 430         


Leu Leu Gly Cys Asp Leu Ser Ile Ala Ser Lys His Ile Ser Lys Pro 
        435                 440                 445             


Val Gln Glu Pro Leu Val Leu Pro Glu Val Phe Gly Asn Leu Asn Ser 
    450                 455                 460                 


Val Met Cys Val Glu Gly Glu Ala Gly Ser Gly Lys Thr Val Leu Leu 
465                 470                 475                 480 


Lys Lys Ile Ala Phe Leu Trp Ala Ser Gly Cys Cys Pro Leu Leu Asn 
                485                 490                 495     


Arg Phe Gln Leu Val Phe Tyr Leu Ser Leu Ser Ser Thr Arg Pro Asp 
            500                 505                 510         


Glu Gly Leu Ala Ser Ile Ile Cys Asp Gln Leu Leu Glu Lys Glu Gly 
        515                 520                 525             


Ser Val Thr Glu Met Cys Val Arg Asn Ile Ile Gln Gln Leu Lys Asn 
    530                 535                 540                 


Gln Val Leu Phe Leu Leu Asp Asp Tyr Lys Glu Ile Cys Ser Ile Pro 
545                 550                 555                 560 


Gln Val Ile Gly Lys Leu Ile Gln Lys Asn His Leu Ser Arg Thr Cys 
                565                 570                 575     


Leu Leu Ile Ala Val Arg Thr Asn Arg Ala Arg Asp Ile Arg Arg Tyr 
            580                 585                 590         


Leu Glu Thr Ile Leu Glu Ile Lys Ala Phe Pro Phe Tyr Asn Thr Val 
        595                 600                 605             


Cys Ile Leu Arg Lys Leu Phe Ser His Asn Met Thr Arg Leu Arg Lys 
    610                 615                 620                 


Phe Met Val Tyr Phe Gly Lys Asn Gln Ser Leu Gln Lys Ile Gln Lys 
625                 630                 635                 640 


Thr Pro Leu Phe Val Ala Ala Ile Cys Ala His Trp Phe Gln Tyr Pro 
                645                 650                 655     


Phe Asp Pro Ser Phe Asp Asp Val Ala Val Phe Lys Ser Tyr Met Glu 
            660                 665                 670         


Arg Leu Ser Leu Arg Asn Lys Ala Thr Ala Glu Ile Leu Lys Ala Thr 
        675                 680                 685             


Val Ser Ser Cys Gly Glu Leu Ala Leu Lys Gly Phe Phe Ser Cys Cys 
    690                 695                 700                 


Phe Glu Phe Asn Asp Asp Asp Leu Ala Glu Ala Gly Val Asp Glu Asp 
705                 710                 715                 720 


Glu Asp Leu Thr Met Cys Leu Met Ser Lys Phe Thr Ala Gln Arg Leu 
                725                 730                 735     


Arg Pro Phe Tyr Arg Phe Leu Ser Pro Ala Phe Gln Glu Phe Leu Ala 
            740                 745                 750         


Gly Met Arg Leu Ile Glu Leu Leu Asp Ser Asp Arg Gln Glu His Gln 
        755                 760                 765             


Asp Leu Gly Leu Tyr His Leu Lys Gln Ile Asn Ser Pro Met Met Thr 
    770                 775                 780                 


Val Ser Ala Tyr Asn Asn Phe Leu Asn Tyr Val Ser Ser Leu Pro Ser 
785                 790                 795                 800 


Thr Lys Ala Gly Pro Lys Ile Val Ser His Leu Leu His Leu Val Asp 
                805                 810                 815     


Asn Lys Glu Ser Leu Glu Asn Ile Ser Glu Asn Asp Asp Tyr Leu Lys 
            820                 825                 830         


His Gln Pro Glu Ile Ser Leu Gln Met Gln Leu Leu Arg Gly Leu Trp 
        835                 840                 845             


Gln Ile Cys Pro Gln Ala Tyr Phe Ser Met Val Ser Glu His Leu Leu 
    850                 855                 860                 


Val Leu Ala Leu Lys Thr Ala Tyr Gln Ser Asn Thr Val Ala Ala Cys 
865                 870                 875                 880 


Ser Pro Phe Val Leu Gln Phe Leu Gln Gly Arg Thr Leu Thr Leu Gly 
                885                 890                 895     


Ala Leu Asn Leu Gln Tyr Phe Phe Asp His Pro Glu Ser Leu Ser Leu 
            900                 905                 910         


Leu Arg Ser Ile His Phe Pro Ile Arg Gly Asn Lys Thr Ser Pro Arg 
        915                 920                 925             


Ala His Phe Ser Val Leu Glu Thr Cys Phe Asp Lys Ser Gln Val Pro 
    930                 935                 940                 


Thr Ile Asp Gln Asp Tyr Ala Ser Ala Phe Glu Pro Met Asn Glu Trp 
945                 950                 955                 960 


Glu Arg Asn Leu Ala Glu Lys Glu Asp Asn Val Lys Ser Tyr Met Asp 
                965                 970                 975     


Met Gln Arg Arg Ala Ser Pro Asp Leu Ser Thr Gly Tyr Trp Lys Leu 
            980                 985                 990         


Ser Pro Lys Gln Tyr Lys Ile Pro  Cys Leu Glu Val Asp  Val Asn Asp 
        995                 1000                 1005             


Ile Asp  Val Val Gly Gln Asp  Met Leu Glu Ile Leu  Met Thr Val 
    1010                 1015                 1020             


Phe Ser  Ala Ser Gln Arg Ile  Glu Leu His Leu Asn  His Ser Arg 
    1025                 1030                 1035             


Gly Phe  Ile Glu Ser Ile Arg  Pro Ala Leu Glu Leu  Ser Lys Ala 
    1040                 1045                 1050             


Ser Val  Thr Lys Cys Ser Ile  Ser Lys Leu Glu Leu  Ser Ala Ala 
    1055                 1060                 1065             


Glu Gln  Glu Leu Leu Leu Thr  Leu Pro Ser Leu Glu  Ser Leu Glu 
    1070                 1075                 1080             


Val Ser  Gly Thr Ile Gln Ser  Gln Asp Gln Ile Phe  Pro Asn Leu 
    1085                 1090                 1095             


Asp Lys  Phe Leu Cys Leu Lys  Glu Leu Ser Val Asp  Leu Glu Gly 
    1100                 1105                 1110             


Asn Ile  Asn Val Phe Ser Val  Ile Pro Glu Glu Phe  Pro Asn Phe 
    1115                 1120                 1125             


His His  Met Glu Lys Leu Leu  Ile Gln Ile Ser Ala  Glu Tyr Asp 
    1130                 1135                 1140             


Pro Ser  Lys Leu Val Lys Leu  Ile Gln Asn Ser Pro  Asn Leu His 
    1145                 1150                 1155             


Val Phe  His Leu Lys Cys Asn  Phe Phe Ser Asp Phe  Gly Ser Leu 
    1160                 1165                 1170             


Met Thr  Met Leu Val Ser Cys  Lys Lys Leu Thr Glu  Ile Lys Phe 
    1175                 1180                 1185             


Ser Asp  Ser Phe Phe Gln Ala  Val Pro Phe Val Ala  Ser Leu Pro 
    1190                 1195                 1200             


Asn Phe  Ile Ser Leu Lys Ile  Leu Asn Leu Glu Gly  Gln Gln Phe 
    1205                 1210                 1215             


Pro Asp  Glu Glu Thr Ser Glu  Lys Phe Ala Tyr Ile  Leu Gly Ser 
    1220                 1225                 1230             


Leu Ser  Asn Leu Glu Glu Leu  Ile Leu Pro Thr Gly  Asp Gly Ile 
    1235                 1240                 1245             


Tyr Arg  Val Ala Lys Leu Ile  Ile Gln Gln Cys Gln  Gln Leu His 
    1250                 1255                 1260             


Cys Leu  Arg Val Leu Ser Phe  Phe Lys Thr Leu Asn  Asp Asp Ser 
    1265                 1270                 1275             


Val Val  Glu Ile Ala Lys Val  Ala Ile Ser Gly Gly  Phe Gln Lys 
    1280                 1285                 1290             


Leu Glu  Asn Leu Lys Leu Ser  Ile Asn His Lys Ile  Thr Glu Glu 
    1295                 1300                 1305             


Gly Tyr  Arg Asn Phe Phe Gln  Ala Leu Asp Asn Met  Pro Asn Leu 
    1310                 1315                 1320             


Gln Glu  Leu Asp Ile Ser Arg  His Phe Thr Glu Cys  Ile Lys Ala 
    1325                 1330                 1335             


Gln Ala  Thr Thr Val Lys Ser  Leu Ser Gln Cys Val  Leu Arg Leu 
    1340                 1345                 1350             


Pro Arg  Leu Ile Arg Leu Asn  Met Leu Ser Trp Leu  Leu Asp Ala 
    1355                 1360                 1365             


Asp Asp  Ile Ala Leu Leu Asn  Val Met Lys Glu Arg  His Pro Gln 
    1370                 1375                 1380             


Ser Lys  Tyr Leu Thr Ile Leu  Gln Lys Trp Ile Leu  Pro Phe Ser 
    1385                 1390                 1395             


Pro Ile  Ile Gln Lys 
    1400             


<210>  90
<211>  910
<212>  PRT
<213>  Homo sapiens

<400>  90

Met Gly Thr Pro Arg Ala Gln His Pro Pro Pro Pro Gln Leu Leu Phe 
1               5                   10                  15      


Leu Ile Leu Leu Ser Cys Pro Trp Ile Gln Gly Leu Pro Leu Lys Glu 
            20                  25                  30          


Glu Glu Ile Leu Pro Glu Pro Gly Ser Glu Thr Pro Thr Val Ala Ser 
        35                  40                  45              


Glu Ala Leu Ala Glu Leu Leu His Gly Ala Leu Leu Arg Arg Gly Pro 
    50                  55                  60                  


Glu Met Gly Tyr Leu Pro Gly Ser Asp Pro Asp Pro Thr Leu Ala Thr 
65                  70                  75                  80  


Pro Pro Ala Gly Gln Thr Leu Ala Val Pro Ser Leu Pro Arg Ala Thr 
                85                  90                  95      


Glu Pro Gly Thr Gly Pro Leu Thr Thr Ala Val Thr Pro Asn Gly Val 
            100                 105                 110         


Arg Gly Ala Gly Pro Thr Ala Pro Glu Leu Leu Thr Pro Pro Pro Gly 
        115                 120                 125             


Thr Thr Ala Pro Pro Pro Pro Ser Pro Ala Ser Pro Gly Pro Pro Leu 
    130                 135                 140                 


Gly Pro Glu Gly Gly Glu Glu Glu Thr Thr Thr Thr Ile Ile Thr Thr 
145                 150                 155                 160 


Thr Thr Val Thr Thr Thr Val Thr Ser Pro Val Leu Cys Asn Asn Asn 
                165                 170                 175     


Ile Ser Glu Gly Glu Gly Tyr Val Glu Ser Pro Asp Leu Gly Ser Pro 
            180                 185                 190         


Val Ser Arg Thr Leu Gly Leu Leu Asp Cys Thr Tyr Ser Ile His Val 
        195                 200                 205             


Tyr Pro Gly Tyr Gly Ile Glu Ile Gln Val Gln Thr Leu Asn Leu Ser 
    210                 215                 220                 


Gln Glu Glu Glu Leu Leu Val Leu Ala Gly Gly Gly Ser Pro Gly Leu 
225                 230                 235                 240 


Ala Pro Arg Leu Leu Ala Asn Ser Ser Met Leu Gly Glu Gly Gln Val 
                245                 250                 255     


Leu Arg Ser Pro Thr Asn Arg Leu Leu Leu His Phe Gln Ser Pro Arg 
            260                 265                 270         


Val Pro Arg Gly Gly Gly Phe Arg Ile His Tyr Gln Ala Tyr Leu Leu 
        275                 280                 285             


Ser Cys Gly Phe Pro Pro Arg Pro Ala His Gly Asp Val Ser Val Thr 
    290                 295                 300                 


Asp Leu His Pro Gly Gly Thr Ala Thr Phe His Cys Asp Ser Gly Tyr 
305                 310                 315                 320 


Gln Leu Gln Gly Glu Glu Thr Leu Ile Cys Leu Asn Gly Thr Arg Pro 
                325                 330                 335     


Ser Trp Asn Gly Glu Thr Pro Ser Cys Met Ala Ser Cys Gly Gly Thr 
            340                 345                 350         


Ile His Asn Ala Thr Leu Gly Arg Ile Val Ser Pro Glu Pro Gly Gly 
        355                 360                 365             


Ala Val Gly Pro Asn Leu Thr Cys Arg Trp Val Ile Glu Ala Ala Glu 
    370                 375                 380                 


Gly Arg Arg Leu His Leu His Phe Glu Arg Val Ser Leu Asp Glu Asp 
385                 390                 395                 400 


Asn Asp Arg Leu Met Val Arg Ser Gly Gly Ser Pro Leu Ser Pro Val 
                405                 410                 415     


Ile Tyr Asp Ser Asp Met Asp Asp Val Pro Glu Arg Gly Leu Ile Ser 
            420                 425                 430         


Asp Ala Gln Ser Leu Tyr Val Glu Leu Leu Ser Glu Thr Pro Ala Asn 
        435                 440                 445             


Pro Leu Leu Leu Ser Leu Arg Phe Glu Ala Phe Glu Glu Asp Arg Cys 
    450                 455                 460                 


Phe Ala Pro Phe Leu Ala His Gly Asn Val Thr Thr Thr Asp Pro Glu 
465                 470                 475                 480 


Tyr Arg Pro Gly Ala Leu Ala Thr Phe Ser Cys Leu Pro Gly Tyr Ala 
                485                 490                 495     


Leu Glu Pro Pro Gly Pro Pro Asn Ala Ile Glu Cys Val Asp Pro Thr 
            500                 505                 510         


Glu Pro His Trp Asn Asp Thr Glu Pro Ala Cys Lys Ala Met Cys Gly 
        515                 520                 525             


Gly Glu Leu Ser Glu Pro Ala Gly Val Val Leu Ser Pro Asp Trp Pro 
    530                 535                 540                 


Gln Ser Tyr Ser Pro Gly Gln Asp Cys Val Trp Gly Val His Val Gln 
545                 550                 555                 560 


Glu Glu Lys Arg Ile Leu Leu Gln Val Glu Ile Leu Asn Val Arg Glu 
                565                 570                 575     


Gly Asp Met Leu Thr Leu Phe Asp Gly Asp Gly Pro Ser Ala Arg Val 
            580                 585                 590         


Leu Ala Gln Leu Arg Gly Pro Gln Pro Arg Arg Arg Leu Leu Ser Ser 
        595                 600                 605             


Gly Pro Asp Leu Thr Leu Gln Phe Gln Ala Pro Pro Gly Pro Pro Asn 
    610                 615                 620                 


Pro Gly Leu Gly Gln Gly Phe Val Leu His Phe Lys Glu Val Pro Arg 
625                 630                 635                 640 


Asn Asp Thr Cys Pro Glu Leu Pro Pro Pro Glu Trp Gly Trp Arg Thr 
                645                 650                 655     


Ala Ser His Gly Asp Leu Ile Arg Gly Thr Val Leu Thr Tyr Gln Cys 
            660                 665                 670         


Glu Pro Gly Tyr Glu Leu Leu Gly Ser Asp Ile Leu Thr Cys Gln Trp 
        675                 680                 685             


Asp Leu Ser Trp Ser Ala Ala Pro Pro Ala Cys Gln Lys Ile Met Thr 
    690                 695                 700                 


Cys Ala Asp Pro Gly Glu Ile Ala Asn Gly His Arg Thr Ala Ser Asp 
705                 710                 715                 720 


Ala Gly Phe Pro Val Gly Ser His Val Gln Tyr Arg Cys Leu Pro Gly 
                725                 730                 735     


Tyr Ser Leu Glu Gly Ala Ala Met Leu Thr Cys Tyr Ser Arg Asp Thr 
            740                 745                 750         


Gly Thr Pro Lys Trp Ser Asp Arg Val Pro Lys Cys Ala Leu Lys Tyr 
        755                 760                 765             


Glu Pro Cys Leu Asn Pro Gly Val Pro Glu Asn Gly Tyr Gln Thr Leu 
    770                 775                 780                 


Tyr Lys His His Tyr Gln Ala Gly Glu Ser Leu Arg Phe Phe Cys Tyr 
785                 790                 795                 800 


Glu Gly Phe Glu Leu Ile Gly Glu Val Thr Ile Thr Cys Val Pro Gly 
                805                 810                 815     


His Pro Ser Gln Trp Thr Ser Gln Pro Pro Leu Cys Lys Val Thr Gln 
            820                 825                 830         


Thr Thr Asp Pro Ser Arg Gln Leu Glu Gly Gly Asn Leu Ala Leu Ala 
        835                 840                 845             


Ile Leu Leu Pro Leu Gly Leu Val Ile Val Leu Gly Ser Gly Val Tyr 
    850                 855                 860                 


Ile Tyr Tyr Thr Lys Leu Gln Gly Lys Ser Leu Phe Gly Phe Ser Gly 
865                 870                 875                 880 


Ser His Ser Tyr Ser Pro Ile Thr Val Glu Ser Asp Phe Ser Asn Pro 
                885                 890                 895     


Leu Tyr Glu Ala Gly Asp Thr Arg Glu Tyr Glu Val Ser Ile 
            900                 905                 910 


<210>  91
<211>  93
<212>  PRT
<213>  Homo sapiens

<400>  91

Met Leu Thr Glu Leu Glu Lys Ala Leu Asn Ser Ile Ile Asp Val Tyr 
1               5                   10                  15      


His Lys Tyr Ser Leu Ile Lys Gly Asn Phe His Ala Val Tyr Arg Asp 
            20                  25                  30          


Asp Leu Lys Lys Leu Leu Glu Thr Glu Cys Pro Gln Tyr Ile Arg Lys 
        35                  40                  45              


Lys Gly Ala Asp Val Trp Phe Lys Glu Leu Asp Ile Asn Thr Asp Gly 
    50                  55                  60                  


Ala Val Asn Phe Gln Glu Phe Leu Ile Leu Val Ile Lys Met Gly Val 
65                  70                  75                  80  


Ala Ala His Lys Lys Ser His Glu Glu Ser His Lys Glu 
                85                  90              


<210>  92
<211>  2017
<212>  PRT
<213>  Homo sapiens

<400>  92

Met Ser Leu Gly Leu Ala Arg Ala Gln Glu Val Glu Leu Thr Leu Glu 
1               5                   10                  15      


Thr Val Ile Gln Thr Leu Glu Ser Ser Val Leu Cys Gln Glu Lys Gly 
            20                  25                  30          


Leu Gly Ala Arg Asp Leu Ala Gln Asp Ala Gln Ile Thr Ser Leu Pro 
        35                  40                  45              


Ala Leu Ile Arg Glu Ile Val Thr Arg Asn Leu Ser Gln Pro Glu Ser 
    50                  55                  60                  


Pro Val Leu Leu Pro Ala Thr Glu Met Ala Ser Leu Leu Ser Leu Gln 
65                  70                  75                  80  


Glu Glu Asn Gln Leu Leu Gln Gln Glu Leu Ser Arg Val Glu Asp Leu 
                85                  90                  95      


Leu Ala Gln Ser Arg Ala Glu Arg Asp Glu Leu Ala Ile Lys Tyr Asn 
            100                 105                 110         


Ala Val Ser Glu Arg Leu Glu Gln Ala Leu Arg Leu Glu Pro Gly Glu 
        115                 120                 125             


Leu Glu Thr Gln Glu Pro Arg Gly Leu Val Arg Gln Ser Val Glu Leu 
    130                 135                 140                 


Arg Arg Gln Leu Gln Glu Glu Gln Ala Ser Tyr Arg Arg Lys Leu Gln 
145                 150                 155                 160 


Ala Tyr Gln Glu Gly Gln Gln Arg Gln Ala Gln Leu Val Gln Arg Leu 
                165                 170                 175     


Gln Gly Lys Ile Leu Gln Tyr Lys Lys Arg Cys Ser Glu Leu Glu Gln 
            180                 185                 190         


Gln Leu Leu Glu Arg Ser Gly Glu Leu Glu Gln Gln Arg Leu Arg Asp 
        195                 200                 205             


Thr Glu His Ser Gln Asp Leu Glu Ser Ala Leu Ile Arg Leu Glu Glu 
    210                 215                 220                 


Glu Gln Gln Arg Ser Ala Ser Leu Ala Gln Val Asn Ala Met Leu Arg 
225                 230                 235                 240 


Glu Gln Leu Asp Gln Ala Gly Ser Ala Asn Gln Ala Leu Ser Glu Asp 
                245                 250                 255     


Ile Arg Lys Val Thr Asn Asp Trp Thr Arg Cys Arg Lys Glu Leu Glu 
            260                 265                 270         


His Arg Glu Ala Ala Trp Arg Arg Glu Glu Glu Ser Phe Asn Ala Tyr 
        275                 280                 285             


Phe Ser Asn Glu His Ser Arg Leu Leu Leu Leu Trp Arg Gln Val Val 
    290                 295                 300                 


Gly Phe Arg Arg Leu Val Ser Glu Val Lys Met Phe Thr Glu Arg Asp 
305                 310                 315                 320 


Leu Leu Gln Leu Gly Gly Glu Leu Ala Arg Thr Ser Arg Ala Val Gln 
                325                 330                 335     


Glu Ala Gly Leu Gly Leu Ser Thr Gly Leu Arg Leu Ala Glu Ser Arg 
            340                 345                 350         


Ala Glu Ala Ala Leu Glu Lys Gln Ala Leu Leu Gln Ala Gln Leu Glu 
        355                 360                 365             


Glu Gln Leu Arg Asp Lys Val Leu Arg Glu Lys Asp Leu Ala Gln Gln 
    370                 375                 380                 


Gln Met Gln Ser Asp Leu Asp Lys Ala Asp Leu Ser Ala Arg Val Thr 
385                 390                 395                 400 


Glu Leu Gly Leu Ala Val Lys Arg Leu Glu Lys Gln Asn Leu Glu Lys 
                405                 410                 415     


Asp Gln Val Asn Lys Asp Leu Thr Glu Lys Leu Glu Ala Leu Glu Ser 
            420                 425                 430         


Leu Arg Leu Gln Glu Gln Ala Ala Leu Glu Thr Glu Asp Gly Glu Gly 
        435                 440                 445             


Leu Gln Gln Thr Leu Arg Asp Leu Ala Gln Ala Val Leu Ser Asp Ser 
    450                 455                 460                 


Glu Ser Gly Val Gln Leu Ser Gly Ser Glu Arg Thr Ala Asp Ala Ser 
465                 470                 475                 480 


Asn Gly Ser Leu Arg Gly Leu Ser Gly Gln Arg Thr Pro Ser Pro Pro 
                485                 490                 495     


Arg Arg Ser Ser Pro Gly Arg Gly Arg Ser Pro Arg Arg Gly Pro Ser 
            500                 505                 510         


Pro Ala Cys Ser Asp Ser Ser Thr Leu Ala Leu Ile His Ser Ala Leu 
        515                 520                 525             


His Lys Arg Gln Leu Gln Val Gln Asp Met Arg Gly Arg Tyr Glu Ala 
    530                 535                 540                 


Ser Gln Asp Leu Leu Gly Thr Leu Arg Lys Gln Leu Ser Asp Ser Glu 
545                 550                 555                 560 


Ser Glu Arg Arg Ala Leu Glu Glu Gln Leu Gln Arg Leu Arg Asp Lys 
                565                 570                 575     


Thr Asp Gly Ala Met Gln Ala His Glu Asp Ala Gln Arg Glu Val Gln 
            580                 585                 590         


Arg Leu Arg Ser Ala Asn Glu Leu Leu Ser Arg Glu Lys Ser Asn Leu 
        595                 600                 605             


Ala His Ser Leu Gln Val Ala Gln Gln Gln Ala Glu Glu Leu Arg Gln 
    610                 615                 620                 


Glu Arg Glu Lys Leu Gln Ala Ala Gln Glu Glu Leu Arg Arg Gln Arg 
625                 630                 635                 640 


Asp Arg Leu Glu Glu Glu Gln Glu Asp Ala Val Gln Asp Gly Ala Arg 
                645                 650                 655     


Val Arg Arg Glu Leu Glu Arg Ser His Arg Gln Leu Glu Gln Leu Glu 
            660                 665                 670         


Gly Lys Arg Ser Val Leu Ala Lys Glu Leu Val Glu Val Arg Glu Ala 
        675                 680                 685             


Leu Ser Arg Ala Thr Leu Gln Arg Asp Met Leu Gln Ala Glu Lys Ala 
    690                 695                 700                 


Glu Val Ala Glu Ala Leu Thr Lys Ala Glu Ala Gly Arg Val Glu Leu 
705                 710                 715                 720 


Glu Leu Ser Met Thr Lys Leu Arg Ala Glu Glu Ala Ser Leu Gln Asp 
                725                 730                 735     


Ser Leu Ser Lys Leu Ser Ala Leu Asn Glu Ser Leu Ala Gln Asp Lys 
            740                 745                 750         


Leu Asp Leu Asn Arg Leu Val Ala Gln Leu Glu Glu Glu Lys Ser Ala 
        755                 760                 765             


Leu Gln Gly Arg Gln Arg Gln Ala Glu Gln Glu Ala Thr Val Ala Arg 
    770                 775                 780                 


Glu Glu Gln Glu Arg Leu Glu Glu Leu Arg Leu Glu Gln Glu Val Ala 
785                 790                 795                 800 


Arg Gln Gly Leu Glu Gly Ser Leu Arg Val Ala Glu Gln Ala Gln Glu 
                805                 810                 815     


Ala Leu Glu Gln Gln Leu Pro Thr Leu Arg His Glu Arg Ser Gln Leu 
            820                 825                 830         


Gln Glu Gln Leu Ala Gln Leu Ser Arg Gln Leu Ser Gly Arg Glu Gln 
        835                 840                 845             


Glu Leu Glu Gln Ala Arg Arg Glu Ala Gln Arg Gln Val Glu Ala Leu 
    850                 855                 860                 


Glu Arg Ala Ala Arg Glu Lys Glu Ala Leu Ala Lys Glu His Ala Gly 
865                 870                 875                 880 


Leu Ala Val Gln Leu Val Ala Ala Glu Arg Glu Gly Arg Thr Leu Ser 
                885                 890                 895     


Glu Glu Ala Thr Arg Leu Arg Leu Glu Lys Glu Ala Leu Glu Gly Ser 
            900                 905                 910         


Leu Phe Glu Val Gln Arg Gln Leu Ala Gln Leu Glu Ala Arg Arg Glu 
        915                 920                 925             


Gln Leu Glu Ala Glu Gly Gln Ala Leu Leu Leu Ala Lys Glu Thr Leu 
    930                 935                 940                 


Thr Gly Glu Leu Ala Gly Leu Arg Gln Gln Ile Ile Ala Thr Gln Glu 
945                 950                 955                 960 


Lys Ala Ser Leu Asp Lys Glu Leu Met Ala Gln Lys Leu Val Gln Ala 
                965                 970                 975     


Glu Arg Glu Ala Gln Ala Ser Leu Arg Glu Gln Arg Ala Ala His Glu 
            980                 985                 990         


Glu Asp Leu Gln Arg Leu Gln Arg  Glu Lys Glu Ala Ala  Trp Arg Glu 
        995                 1000                 1005             


Leu Glu  Ala Glu Arg Ala Gln  Leu Gln Ser Gln Leu  Gln Arg Glu 
    1010                 1015                 1020             


Gln Glu  Glu Leu Leu Ala Arg  Leu Glu Ala Glu Lys  Glu Glu Leu 
    1025                 1030                 1035             


Ser Glu  Glu Ile Ala Ala Leu  Gln Gln Glu Arg Asp  Glu Gly Leu 
    1040                 1045                 1050             


Leu Leu  Ala Glu Ser Glu Lys  Gln Gln Ala Leu Ser  Leu Lys Glu 
    1055                 1060                 1065             


Ser Glu  Lys Thr Ala Leu Ser  Glu Lys Leu Met Gly  Thr Arg His 
    1070                 1075                 1080             


Ser Leu  Ala Thr Ile Ser Leu  Glu Met Glu Arg Gln  Lys Arg Asp 
    1085                 1090                 1095             


Ala Gln  Ser Arg Gln Glu Gln  Asp Arg Ser Thr Val  Asn Ala Leu 
    1100                 1105                 1110             


Thr Ser  Glu Leu Arg Asp Leu  Arg Ala Gln Arg Glu  Glu Ala Ala 
    1115                 1120                 1125             


Ala Ala  His Ala Gln Glu Val  Arg Arg Leu Gln Glu  Gln Ala Arg 
    1130                 1135                 1140             


Asp Leu  Gly Lys Gln Arg Asp  Ser Cys Leu Arg Glu  Ala Glu Glu 
    1145                 1150                 1155             


Leu Arg  Thr Gln Leu Arg Leu  Leu Glu Asp Ala Arg  Asp Gly Leu 
    1160                 1165                 1170             


Arg Arg  Glu Leu Leu Glu Ala  Gln Arg Lys Leu Arg  Glu Ser Gln 
    1175                 1180                 1185             


Glu Gly  Arg Glu Val Gln Arg  Gln Glu Ala Gly Glu  Leu Arg Arg 
    1190                 1195                 1200             


Ser Leu  Gly Glu Gly Ala Lys  Glu Arg Glu Ala Leu  Arg Arg Ser 
    1205                 1210                 1215             


Asn Glu  Glu Leu Arg Ser Ala  Val Lys Lys Ala Glu  Ser Glu Arg 
    1220                 1225                 1230             


Ile Ser  Leu Lys Leu Ala Asn  Glu Asp Lys Glu Gln  Lys Leu Ala 
    1235                 1240                 1245             


Leu Leu  Glu Glu Ala Arg Thr  Ala Val Gly Lys Glu  Ala Gly Glu 
    1250                 1255                 1260             


Leu Arg  Thr Gly Leu Gln Glu  Val Glu Arg Ser Arg  Leu Glu Ala 
    1265                 1270                 1275             


Arg Arg  Glu Leu Gln Glu Leu  Arg Arg Gln Met Lys  Met Leu Asp 
    1280                 1285                 1290             


Ser Glu  Asn Thr Arg Leu Gly  Arg Glu Leu Ala Glu  Leu Gln Gly 
    1295                 1300                 1305             


Arg Leu  Ala Leu Gly Glu Arg  Ala Glu Lys Glu Ser  Arg Arg Glu 
    1310                 1315                 1320             


Thr Leu  Gly Leu Arg Gln Arg  Leu Leu Lys Gly Glu  Ala Ser Leu 
    1325                 1330                 1335             


Glu Val  Met Arg Gln Glu Leu  Gln Val Ala Gln Arg  Lys Leu Gln 
    1340                 1345                 1350             


Glu Gln  Glu Gly Glu Phe Arg  Thr Arg Glu Arg Arg  Leu Leu Gly 
    1355                 1360                 1365             


Ser Leu  Glu Glu Ala Arg Gly  Thr Glu Lys Gln Gln  Leu Asp His 
    1370                 1375                 1380             


Ala Arg  Gly Leu Glu Leu Lys  Leu Glu Ala Ala Arg  Ala Glu Ala 
    1385                 1390                 1395             


Ala Glu  Leu Gly Leu Arg Leu  Ser Ala Ala Glu Gly  Arg Ala Gln 
    1400                 1405                 1410             


Gly Leu  Glu Ala Glu Leu Ala  Arg Val Glu Val Gln  Arg Arg Ala 
    1415                 1420                 1425             


Ala Glu  Ala Gln Leu Gly Gly  Leu Arg Ser Ala Leu  Arg Arg Gly 
    1430                 1435                 1440             


Leu Gly  Leu Gly Arg Ala Pro  Ser Pro Ala Pro Arg  Pro Val Pro 
    1445                 1450                 1455             


Gly Ser  Pro Ala Arg Asp Ala  Pro Ala Glu Gly Ser  Gly Glu Gly 
    1460                 1465                 1470             


Leu Asn  Ser Pro Ser Thr Leu  Glu Cys Ser Pro Gly  Ser Gln Pro 
    1475                 1480                 1485             


Pro Ser  Pro Gly Pro Ala Thr  Ser Pro Ala Ser Pro  Asp Leu Asp 
    1490                 1495                 1500             


Pro Glu  Ala Val Arg Gly Ala  Leu Arg Glu Phe Leu  Gln Glu Leu 
    1505                 1510                 1515             


Arg Ser  Ala Gln Arg Glu Arg  Asp Glu Leu Arg Thr  Gln Thr Ser 
    1520                 1525                 1530             


Ala Leu  Asn Arg Gln Leu Ala  Glu Met Glu Ala Glu  Arg Asp Ser 
    1535                 1540                 1545             


Ala Thr  Ser Arg Ala Arg Gln  Leu Gln Lys Ala Val  Ala Glu Ser 
    1550                 1555                 1560             


Glu Glu  Ala Arg Arg Ser Val  Asp Gly Arg Leu Ser  Gly Val Gln 
    1565                 1570                 1575             


Ala Glu  Leu Ala Leu Gln Glu  Glu Ser Val Arg Arg  Ser Glu Arg 
    1580                 1585                 1590             


Glu Arg  Arg Ala Thr Leu Asp  Gln Val Ala Thr Leu  Glu Arg Ser 
    1595                 1600                 1605             


Leu Gln  Ala Thr Glu Ser Glu  Leu Arg Ala Ser Gln  Glu Lys Ile 
    1610                 1615                 1620             


Ser Lys  Met Lys Ala Asn Glu  Thr Lys Leu Glu Gly  Asp Lys Arg 
    1625                 1630                 1635             


Arg Leu  Lys Glu Val Leu Asp  Ala Ser Glu Ser Arg  Thr Val Lys 
    1640                 1645                 1650             


Leu Glu  Leu Gln Arg Arg Ser  Leu Glu Gly Glu Leu  Gln Arg Ser 
    1655                 1660                 1665             


Arg Leu  Gly Leu Ser Asp Arg  Glu Ala Gln Ala Gln  Ala Leu Gln 
    1670                 1675                 1680             


Asp Arg  Val Asp Ser Leu Gln  Arg Gln Val Ala Asp  Ser Glu Val 
    1685                 1690                 1695             


Lys Ala  Gly Thr Leu Gln Leu  Thr Val Glu Arg Leu  Asn Gly Ala 
    1700                 1705                 1710             


Leu Ala  Lys Val Glu Glu Ser  Glu Gly Ala Leu Arg  Asp Lys Val 
    1715                 1720                 1725             


Arg Gly  Leu Thr Glu Ala Leu  Ala Gln Ser Ser Ala  Ser Leu Asn 
    1730                 1735                 1740             


Ser Thr  Arg Asp Lys Asn Leu  His Leu Gln Lys Ala  Leu Thr Ala 
    1745                 1750                 1755             


Cys Glu  His Asp Arg Gln Val  Leu Gln Glu Arg Leu  Asp Ala Ala 
    1760                 1765                 1770             


Arg Gln  Ala Leu Ser Glu Ala  Arg Lys Gln Ser Ser  Ser Leu Gly 
    1775                 1780                 1785             


Glu Gln  Val Gln Thr Leu Arg  Gly Glu Val Ala Asp  Leu Glu Leu 
    1790                 1795                 1800             


Gln Arg  Val Glu Ala Glu Gly  Gln Leu Gln Gln Leu  Arg Glu Val 
    1805                 1810                 1815             


Leu Arg  Gln Arg Gln Glu Gly  Glu Ala Ala Ala Leu  Asn Thr Val 
    1820                 1825                 1830             


Gln Lys  Leu Gln Asp Glu Arg  Arg Leu Leu Gln Glu  Arg Leu Gly 
    1835                 1840                 1845             


Ser Leu  Gln Arg Ala Leu Ala  Gln Leu Glu Ala Glu  Lys Arg Glu 
    1850                 1855                 1860             


Val Glu  Arg Ser Ala Leu Arg  Leu Glu Lys Asp Arg  Val Ala Leu 
    1865                 1870                 1875             


Arg Arg  Thr Leu Asp Lys Val  Glu Arg Glu Lys Leu  Arg Ser His 
    1880                 1885                 1890             


Glu Asp  Thr Val Arg Leu Ser  Ala Glu Lys Gly Arg  Leu Asp Arg 
    1895                 1900                 1905             


Thr Leu  Thr Gly Ala Glu Leu  Glu Leu Ala Glu Ala  Gln Arg Gln 
    1910                 1915                 1920             


Ile Gln  Gln Leu Glu Ala Gln  Val Val Val Leu Glu  Gln Ser His 
    1925                 1930                 1935             


Ser Pro  Ala Gln Leu Glu Val  Asp Ala Gln Gln Gln  Gln Leu Glu 
    1940                 1945                 1950             


Leu Gln  Gln Glu Val Glu Arg  Leu Arg Ser Ala Gln  Ala Gln Thr 
    1955                 1960                 1965             


Glu Arg  Thr Leu Glu Ala Arg  Glu Arg Ala His Arg  Gln Arg Val 
    1970                 1975                 1980             


Arg Gly  Leu Glu Glu Gln Val  Ser Thr Leu Lys Gly  Gln Leu Gln 
    1985                 1990                 1995             


Gln Glu  Leu Arg Arg Ser Ser  Ala Pro Phe Ser Pro  Pro Ser Gly 
    2000                 2005                 2010             


Pro Pro  Glu Lys 
    2015         


<210>  93
<211>  1544
<212>  PRT
<213>  Homo sapiens

<400>  93

Met Glu Ala Ala Thr Thr Leu His Pro Gly Pro Arg Pro Ala Leu Pro 
1               5                   10                  15      


Leu Gly Gly Pro Gly Pro Leu Gly Glu Phe Leu Pro Pro Pro Glu Cys 
            20                  25                  30          


Pro Val Phe Glu Pro Ser Trp Glu Glu Phe Ala Asp Pro Phe Ala Phe 
        35                  40                  45              


Ile His Lys Ile Arg Pro Ile Ala Glu Gln Thr Gly Ile Cys Lys Val 
    50                  55                  60                  


Arg Pro Pro Pro Asp Trp Gln Pro Pro Phe Ala Cys Asp Val Asp Lys 
65                  70                  75                  80  


Leu His Phe Thr Pro Arg Ile Gln Arg Leu Asn Glu Leu Glu Ala Gln 
                85                  90                  95      


Thr Arg Val Lys Leu Asn Phe Leu Asp Gln Ile Ala Lys Tyr Trp Glu 
            100                 105                 110         


Leu Gln Gly Ser Thr Leu Lys Ile Pro His Val Glu Arg Lys Ile Leu 
        115                 120                 125             


Asp Leu Phe Gln Leu Asn Lys Leu Val Ala Glu Glu Gly Gly Phe Ala 
    130                 135                 140                 


Val Val Cys Lys Asp Arg Lys Trp Thr Lys Ile Ala Thr Lys Met Gly 
145                 150                 155                 160 


Phe Ala Pro Gly Lys Ala Val Gly Ser His Ile Arg Gly His Tyr Glu 
                165                 170                 175     


Arg Ile Leu Asn Pro Tyr Asn Leu Phe Leu Ser Gly Asp Ser Leu Arg 
            180                 185                 190         


Cys Leu Gln Lys Pro Asn Leu Thr Thr Asp Thr Lys Asp Lys Glu Tyr 
        195                 200                 205             


Lys Pro His Asp Ile Pro Gln Arg Gln Ser Val Gln Pro Ser Glu Thr 
    210                 215                 220                 


Cys Pro Pro Ala Arg Arg Ala Lys Arg Met Arg Ala Glu Ala Met Asn 
225                 230                 235                 240 


Ile Lys Ile Glu Pro Glu Glu Thr Thr Glu Ala Arg Thr His Asn Leu 
                245                 250                 255     


Arg Arg Arg Met Gly Cys Pro Thr Pro Lys Cys Glu Asn Glu Lys Glu 
            260                 265                 270         


Met Lys Ser Ser Ile Lys Gln Glu Pro Ile Glu Arg Lys Asp Tyr Ile 
        275                 280                 285             


Val Glu Asn Glu Lys Glu Lys Pro Lys Ser Arg Ser Lys Lys Ala Thr 
    290                 295                 300                 


Asn Ala Val Asp Leu Tyr Val Cys Leu Leu Cys Gly Ser Gly Asn Asp 
305                 310                 315                 320 


Glu Asp Arg Leu Leu Leu Cys Asp Gly Cys Asp Asp Ser Tyr His Thr 
                325                 330                 335     


Phe Cys Leu Ile Pro Pro Leu His Asp Val Pro Lys Gly Asp Trp Arg 
            340                 345                 350         


Cys Pro Lys Cys Leu Ala Gln Glu Cys Ser Lys Pro Gln Glu Ala Phe 
        355                 360                 365             


Gly Phe Glu Gln Ala Ala Arg Asp Tyr Thr Leu Arg Thr Phe Gly Glu 
    370                 375                 380                 


Met Ala Asp Ala Phe Lys Ser Asp Tyr Phe Asn Met Pro Val His Met 
385                 390                 395                 400 


Val Pro Thr Glu Leu Val Glu Lys Glu Phe Trp Arg Leu Val Ser Thr 
                405                 410                 415     


Ile Glu Glu Asp Val Thr Val Glu Tyr Gly Ala Asp Ile Ala Ser Lys 
            420                 425                 430         


Glu Phe Gly Ser Gly Phe Pro Val Arg Asp Gly Lys Ile Lys Leu Ser 
        435                 440                 445             


Pro Glu Glu Glu Glu Tyr Leu Asp Ser Gly Trp Asn Leu Asn Asn Met 
    450                 455                 460                 


Pro Val Met Glu Gln Ser Val Leu Ala His Ile Thr Ala Asp Ile Cys 
465                 470                 475                 480 


Gly Met Lys Leu Pro Trp Leu Tyr Val Gly Met Cys Phe Ser Ser Phe 
                485                 490                 495     


Cys Trp His Ile Glu Asp His Trp Ser Tyr Ser Ile Asn Tyr Leu His 
            500                 505                 510         


Trp Gly Glu Pro Lys Thr Trp Tyr Gly Val Pro Gly Tyr Ala Ala Glu 
        515                 520                 525             


Gln Leu Glu Asn Val Met Lys Lys Leu Ala Pro Glu Leu Phe Val Ser 
    530                 535                 540                 


Gln Pro Asp Leu Leu His Gln Leu Val Thr Ile Met Asn Pro Asn Thr 
545                 550                 555                 560 


Leu Met Thr His Glu Val Pro Val Tyr Arg Thr Asn Gln Cys Ala Gly 
                565                 570                 575     


Glu Phe Val Ile Thr Phe Pro Arg Ala Tyr His Ser Gly Phe Asn Gln 
            580                 585                 590         


Gly Phe Asn Phe Ala Glu Ala Val Asn Phe Cys Thr Val Asp Trp Leu 
        595                 600                 605             


Pro Leu Gly Arg Gln Cys Val Glu His Tyr Arg Leu Leu His Arg Tyr 
    610                 615                 620                 


Cys Val Phe Ser His Asp Glu Met Ile Cys Lys Met Ala Ser Lys Ala 
625                 630                 635                 640 


Asp Val Leu Asp Val Val Val Ala Ser Thr Val Gln Lys Asp Met Ala 
                645                 650                 655     


Ile Met Ile Glu Asp Glu Lys Ala Leu Arg Glu Thr Val Arg Lys Leu 
            660                 665                 670         


Gly Val Ile Asp Ser Glu Arg Met Asp Phe Glu Leu Leu Pro Asp Asp 
        675                 680                 685             


Glu Arg Gln Cys Val Lys Cys Lys Thr Thr Cys Phe Met Ser Ala Ile 
    690                 695                 700                 


Ser Cys Ser Cys Lys Pro Gly Leu Leu Val Cys Leu His His Val Lys 
705                 710                 715                 720 


Glu Leu Cys Ser Cys Pro Pro Tyr Lys Tyr Lys Leu Arg Tyr Arg Tyr 
                725                 730                 735     


Thr Leu Asp Asp Leu Tyr Pro Met Met Asn Ala Leu Lys Leu Arg Ala 
            740                 745                 750         


Glu Ser Tyr Asn Glu Trp Ala Leu Asn Val Asn Glu Ala Leu Glu Ala 
        755                 760                 765             


Lys Ile Thr Lys Lys Lys Ser Leu Val Ser Phe Lys Ala Leu Ile Glu 
    770                 775                 780                 


Glu Ser Glu Met Lys Lys Phe Pro Asp Asn Asp Leu Leu Arg His Leu 
785                 790                 795                 800 


Arg Leu Val Thr Gln Asp Ala Glu Lys Cys Ala Ser Val Ala Gln Gln 
                805                 810                 815     


Leu Leu Asn Gly Lys Arg Gln Thr Arg Tyr Arg Ser Gly Gly Gly Lys 
            820                 825                 830         


Ser Gln Asn Gln Leu Thr Val Asn Glu Leu Arg Gln Phe Val Thr Gln 
        835                 840                 845             


Leu Tyr Ala Leu Pro Cys Val Leu Ser Gln Thr Pro Leu Leu Lys Asp 
    850                 855                 860                 


Leu Leu Asn Arg Val Glu Asp Phe Gln Gln His Ser Gln Lys Leu Leu 
865                 870                 875                 880 


Ser Glu Glu Thr Pro Ser Ala Ala Glu Leu Gln Asp Leu Leu Asp Val 
                885                 890                 895     


Ser Phe Glu Phe Asp Val Glu Leu Pro Gln Leu Ala Glu Met Arg Ile 
            900                 905                 910         


Arg Leu Glu Gln Ala Arg Trp Leu Glu Glu Val Gln Gln Ala Cys Leu 
        915                 920                 925             


Asp Pro Ser Ser Leu Thr Leu Asp Asp Met Arg Arg Leu Ile Asp Leu 
    930                 935                 940                 


Gly Val Gly Leu Ala Pro Tyr Ser Ala Val Glu Lys Ala Met Ala Arg 
945                 950                 955                 960 


Leu Gln Glu Leu Leu Thr Val Ser Glu His Trp Asp Asp Lys Ala Lys 
                965                 970                 975     


Ser Leu Leu Lys Ala Arg Pro Arg His Ser Leu Asn Ser Leu Ala Thr 
            980                 985                 990         


Ala Val Lys Glu Ile Glu Glu Ile  Pro Ala Tyr Leu Pro  Asn Gly Ala 
        995                 1000                 1005             


Ala Leu  Lys Asp Ser Val Gln  Arg Ala Arg Asp Trp  Leu Gln Asp 
    1010                 1015                 1020             


Val Glu  Gly Leu Gln Ala Gly  Gly Arg Val Pro Val  Leu Asp Thr 
    1025                 1030                 1035             


Leu Ile  Glu Leu Val Thr Arg  Gly Arg Ser Ile Pro  Val His Leu 
    1040                 1045                 1050             


Asn Ser  Leu Pro Arg Leu Glu  Thr Leu Val Ala Glu  Val Gln Ala 
    1055                 1060                 1065             


Trp Lys  Glu Cys Ala Val Asn  Thr Phe Leu Thr Glu  Asn Ser Pro 
    1070                 1075                 1080             


Tyr Ser  Leu Leu Glu Val Leu  Cys Pro Arg Cys Asp  Ile Gly Leu 
    1085                 1090                 1095             


Leu Gly  Leu Lys Arg Lys Gln  Arg Lys Leu Lys Glu  Pro Leu Pro 
    1100                 1105                 1110             


Asn Gly  Lys Lys Lys Ser Thr  Lys Leu Glu Ser Leu  Ser Asp Leu 
    1115                 1120                 1125             


Glu Arg  Ala Leu Thr Glu Ser  Lys Glu Thr Ala Ser  Ala Met Ala 
    1130                 1135                 1140             


Thr Leu  Gly Glu Ala Arg Leu  Arg Glu Met Glu Ala  Leu Gln Ser 
    1145                 1150                 1155             


Leu Arg  Leu Ala Asn Glu Gly  Lys Leu Leu Ser Pro  Leu Gln Asp 
    1160                 1165                 1170             


Val Asp  Ile Lys Ile Cys Leu  Cys Gln Lys Ala Pro  Ala Ala Pro 
    1175                 1180                 1185             


Met Ile  Gln Cys Glu Leu Cys  Arg Asp Ala Phe His  Thr Ser Cys 
    1190                 1195                 1200             


Val Ala  Val Pro Ser Ile Ser  Gln Gly Leu Arg Ile  Trp Leu Cys 
    1205                 1210                 1215             


Pro His  Cys Arg Arg Ser Glu  Lys Pro Pro Leu Glu  Lys Ile Leu 
    1220                 1225                 1230             


Pro Leu  Leu Ala Ser Leu Gln  Arg Ile Arg Val Arg  Leu Pro Glu 
    1235                 1240                 1245             


Gly Asp  Ala Leu Arg Tyr Met  Ile Glu Arg Thr Val  Asn Trp Gln 
    1250                 1255                 1260             


His Arg  Ala Gln Gln Leu Leu  Ser Ser Gly Asn Leu  Lys Phe Val 
    1265                 1270                 1275             


Gln Asp  Arg Val Gly Ser Gly  Leu Leu Tyr Ser Arg  Trp Gln Ala 
    1280                 1285                 1290             


Ser Ala  Gly Gln Val Ser Asp  Thr Asn Lys Val Ser  Gln Pro Pro 
    1295                 1300                 1305             


Gly Thr  Thr Ser Phe Ser Leu  Pro Asp Asp Trp Asp  Asn Arg Thr 
    1310                 1315                 1320             


Ser Tyr  Leu His Ser Pro Phe  Ser Thr Gly Arg Ser  Cys Ile Pro 
    1325                 1330                 1335             


Leu His  Gly Val Ser Pro Glu  Val Asn Glu Leu Leu  Met Glu Ala 
    1340                 1345                 1350             


Gln Leu  Leu Gln Val Ser Leu  Pro Glu Ile Gln Glu  Leu Tyr Gln 
    1355                 1360                 1365             


Thr Leu  Leu Ala Lys Pro Ser  Pro Ala Gln Gln Thr  Asp Arg Ser 
    1370                 1375                 1380             


Ser Pro  Val Arg Pro Ser Ser  Glu Lys Asn Asp Cys  Cys Arg Gly 
    1385                 1390                 1395             


Lys Arg  Asp Gly Ile Asn Ser  Leu Glu Arg Lys Leu  Lys Arg Arg 
    1400                 1405                 1410             


Leu Glu  Arg Glu Gly Leu Ser  Ser Glu Arg Trp Glu  Arg Val Lys 
    1415                 1420                 1425             


Lys Met  Arg Thr Pro Lys Lys  Lys Lys Ile Lys Leu  Ser His Pro 
    1430                 1435                 1440             


Lys Asp  Met Asn Asn Phe Lys  Leu Glu Arg Glu Arg  Ser Tyr Glu 
    1445                 1450                 1455             


Leu Val  Arg Ser Ala Glu Thr  His Ser Leu Pro Ser  Asp Thr Ser 
    1460                 1465                 1470             


Tyr Ser  Glu Gln Glu Asp Ser  Glu Asp Glu Asp Ala  Ile Cys Pro 
    1475                 1480                 1485             


Ala Val  Ser Cys Leu Gln Pro  Glu Gly Asp Glu Val  Asp Trp Val 
    1490                 1495                 1500             


Gln Cys  Asp Gly Ser Cys Asn  Gln Trp Phe His Gln  Val Cys Val 
    1505                 1510                 1515             


Gly Val  Ser Pro Glu Met Ala  Glu Lys Glu Asp Tyr  Ile Cys Val 
    1520                 1525                 1530             


Arg Cys  Thr Val Lys Asp Ala  Pro Ser Arg Lys 
    1535                 1540                 


<210>  94
<211>  826
<212>  PRT
<213>  Homo sapiens

<400>  94

Met Val Ala Pro Val Leu Glu Thr Ser His Val Phe Cys Cys Pro Asn 
1               5                   10                  15      


Arg Val Arg Gly Val Leu Asn Trp Ser Ser Gly Pro Arg Gly Leu Leu 
            20                  25                  30          


Ala Phe Gly Thr Ser Cys Ser Val Val Leu Tyr Asp Pro Leu Lys Arg 
        35                  40                  45              


Val Val Val Thr Asn Leu Asn Gly His Thr Ala Arg Val Asn Cys Ile 
    50                  55                  60                  


Gln Trp Ile Cys Lys Gln Asp Gly Ser Pro Ser Thr Glu Leu Val Ser 
65                  70                  75                  80  


Gly Gly Ser Asp Asn Gln Val Ile His Trp Glu Ile Glu Asp Asn Gln 
                85                  90                  95      


Leu Leu Lys Ala Val His Leu Gln Gly His Glu Gly Pro Val Tyr Ala 
            100                 105                 110         


Val His Ala Val Tyr Gln Arg Arg Thr Ser Asp Pro Ala Leu Cys Thr 
        115                 120                 125             


Leu Ile Val Ser Ala Ala Ala Asp Ser Ala Val Arg Leu Trp Ser Lys 
    130                 135                 140                 


Lys Gly Pro Glu Val Met Cys Leu Gln Thr Leu Asn Phe Gly Asn Gly 
145                 150                 155                 160 


Phe Ala Leu Ala Leu Cys Leu Ser Phe Leu Pro Asn Thr Asp Val Pro 
                165                 170                 175     


Ile Leu Ala Cys Gly Asn Asp Asp Cys Arg Ile His Ile Phe Ala Gln 
            180                 185                 190         


Gln Asn Asp Gln Phe Gln Lys Val Leu Ser Leu Cys Gly His Glu Asp 
        195                 200                 205             


Trp Ile Arg Gly Val Glu Trp Ala Ala Phe Gly Arg Asp Leu Phe Leu 
    210                 215                 220                 


Ala Ser Cys Ser Gln Asp Cys Leu Ile Arg Ile Trp Lys Leu Tyr Ile 
225                 230                 235                 240 


Lys Ser Thr Ser Leu Glu Thr Gln Asp Asp Asp Asn Ile Arg Leu Lys 
                245                 250                 255     


Glu Asn Thr Phe Thr Ile Glu Asn Glu Ser Val Lys Ile Ala Phe Ala 
            260                 265                 270         


Val Thr Leu Glu Thr Val Leu Ala Gly His Glu Asn Trp Val Asn Ala 
        275                 280                 285             


Val His Trp Gln Pro Val Phe Tyr Lys Asp Gly Val Leu Gln Gln Pro 
    290                 295                 300                 


Val Arg Leu Leu Ser Ala Ser Met Asp Lys Thr Met Ile Leu Trp Ala 
305                 310                 315                 320 


Pro Asp Glu Glu Ser Gly Val Trp Leu Glu Gln Val Arg Val Gly Glu 
                325                 330                 335     


Val Gly Gly Asn Thr Leu Gly Phe Tyr Asp Cys Gln Phe Asn Glu Asp 
            340                 345                 350         


Gly Ser Met Ile Ile Ala His Ala Phe His Gly Ala Leu His Leu Trp 
        355                 360                 365             


Lys Gln Asn Thr Val Asn Pro Arg Glu Trp Thr Pro Glu Ile Val Ile 
    370                 375                 380                 


Ser Gly His Phe Asp Gly Val Gln Asp Leu Val Trp Asp Pro Glu Gly 
385                 390                 395                 400 


Glu Phe Ile Ile Thr Val Gly Thr Asp Gln Thr Thr Arg Leu Phe Ala 
                405                 410                 415     


Pro Trp Lys Arg Lys Asp Gln Ser Gln Val Thr Trp His Glu Ile Ala 
            420                 425                 430         


Arg Pro Gln Ile His Gly Tyr Asp Leu Lys Cys Leu Ala Met Ile Asn 
        435                 440                 445             


Arg Phe Gln Phe Val Ser Gly Ala Asp Glu Lys Val Leu Arg Val Phe 
    450                 455                 460                 


Ser Ala Pro Arg Asn Phe Val Glu Asn Phe Cys Ala Ile Thr Gly Gln 
465                 470                 475                 480 


Ser Leu Asn His Val Leu Cys Asn Gln Asp Ser Asp Leu Pro Glu Gly 
                485                 490                 495     


Ala Thr Val Pro Ala Leu Gly Leu Ser Asn Lys Ala Val Phe Gln Gly 
            500                 505                 510         


Asp Ile Ala Ser Gln Pro Ser Asp Glu Glu Glu Leu Leu Thr Ser Thr 
        515                 520                 525             


Gly Phe Glu Tyr Gln Gln Val Ala Phe Gln Pro Ser Ile Leu Thr Glu 
    530                 535                 540                 


Pro Pro Thr Glu Asp His Leu Leu Gln Asn Thr Leu Trp Pro Glu Val 
545                 550                 555                 560 


Gln Lys Leu Tyr Gly His Gly Tyr Glu Ile Phe Cys Val Thr Cys Asn 
                565                 570                 575     


Ser Ser Lys Thr Leu Leu Ala Ser Ala Cys Lys Ala Ala Lys Lys Glu 
            580                 585                 590         


His Ala Ala Ile Ile Leu Trp Asn Thr Thr Ser Trp Lys Gln Val Gln 
        595                 600                 605             


Asn Leu Val Phe His Ser Leu Thr Val Thr Gln Met Ala Phe Ser Pro 
    610                 615                 620                 


Asn Glu Lys Phe Leu Leu Ala Val Ser Arg Asp Arg Thr Trp Ser Leu 
625                 630                 635                 640 


Trp Lys Lys Gln Asp Thr Ile Ser Pro Glu Phe Glu Pro Val Phe Ser 
                645                 650                 655     


Leu Phe Ala Phe Thr Asn Lys Ile Thr Ser Val His Ser Arg Ile Ile 
            660                 665                 670         


Trp Ser Cys Asp Trp Ser Pro Asp Ser Lys Tyr Phe Phe Thr Gly Ser 
        675                 680                 685             


Arg Asp Lys Lys Val Val Val Trp Gly Glu Cys Asp Ser Thr Asp Asp 
    690                 695                 700                 


Cys Ile Glu His Asn Ile Gly Pro Cys Ser Ser Val Leu Asp Val Gly 
705                 710                 715                 720 


Gly Ala Val Thr Ala Val Ser Val Cys Pro Val Leu His Pro Ser Gln 
                725                 730                 735     


Arg Tyr Val Val Ala Val Gly Leu Glu Cys Gly Lys Ile Cys Leu Tyr 
            740                 745                 750         


Thr Trp Lys Lys Thr Asp Gln Val Pro Glu Ile Asn Asp Trp Thr His 
        755                 760                 765             


Cys Val Glu Thr Ser Gln Ser Gln Ser His Thr Leu Ala Ile Arg Lys 
    770                 775                 780                 


Leu Cys Trp Lys Asn Cys Ser Gly Lys Thr Glu Gln Lys Glu Ala Glu 
785                 790                 795                 800 


Gly Ala Glu Trp Leu His Phe Ala Ser Cys Gly Glu Asp His Thr Val 
                805                 810                 815     


Lys Ile His Arg Val Asn Lys Cys Ala Leu 
            820                 825     


<210>  95
<211>  454
<212>  PRT
<213>  Homo sapiens

<400>  95

Met Trp Leu Glu Ile Leu Leu Ala Ser Val Leu Gly Phe Val Ile Tyr 
1               5                   10                  15      


Trp Phe Val Ser Lys Asp Lys Glu Glu Thr Leu Leu Leu Gly Asp Gly 
            20                  25                  30          


Trp Trp Gly Pro Gly Ser Arg Pro Ala Ala Ala Glu Asp Glu Ser Ile 
        35                  40                  45              


Arg Pro Phe Lys Val Glu Thr Ser Asp Glu Glu Ile Asn Asp Leu His 
    50                  55                  60                  


Gln Arg Ile Glu Lys Phe Arg Leu Thr Pro Pro Leu Glu Asp Ser Arg 
65                  70                  75                  80  


Phe His Tyr Gly Phe Asn Ser Asn Tyr Leu Lys Lys Ile Ile Ser Tyr 
                85                  90                  95      


Trp Arg Asn Thr Phe Asp Trp Arg Lys Gln Val Glu Val Leu Asn Lys 
            100                 105                 110         


Tyr Pro His Phe Lys Thr Lys Ile Glu Gly Leu Asp Ile His Phe Ile 
        115                 120                 125             


His Val Lys Pro Pro Gln Leu Pro Ser Gly Arg Thr Ala Lys Pro Leu 
    130                 135                 140                 


Leu Met Val His Gly Trp Pro Gly Cys Phe Tyr Glu Phe Tyr Lys Ile 
145                 150                 155                 160 


Ile Pro Leu Leu Thr Asp Pro Lys Asn His Gly Leu Ser Asp Glu His 
                165                 170                 175     


Val Phe Glu Val Ile Cys Pro Ser Ile Pro Gly Tyr Gly Phe Ser Glu 
            180                 185                 190         


Ala Ser Ser Lys Lys Gly Phe Asn Ser Val Ala Ala Ala Arg Ile Phe 
        195                 200                 205             


Tyr Lys Leu Met Leu Arg Leu Gly Phe Gln Glu Phe Tyr Leu Gln Gly 
    210                 215                 220                 


Gly Asp Trp Gly Ser Leu Ile Cys Thr Asn Met Ala Gln Leu Val Pro 
225                 230                 235                 240 


Ser His Val Lys Gly Leu His Leu Asn Val Ala Leu Val Leu Arg Asn 
                245                 250                 255     


Val Tyr Thr Leu Thr Phe Phe Leu Gly Arg Arg Leu Gly Arg Leu Phe 
            260                 265                 270         


Gly Tyr Thr Glu Arg Asp Leu Glu Leu Leu Tyr Pro Phe Lys Lys Thr 
        275                 280                 285             


Phe Tyr Thr Leu Met Arg Glu Ser Gly Tyr Met His Ile Gln Ser Thr 
    290                 295                 300                 


Lys Pro Asp Thr Val Gly Cys Ala Leu Asn Asp Ser Pro Val Gly Leu 
305                 310                 315                 320 


Ala Ala Tyr Ile Leu Glu Lys Phe Ser Thr Trp Thr Asn Glu Glu Phe 
                325                 330                 335     


Arg Asp Leu Glu Asp Gly Gly Leu Glu Arg Lys Phe Ser Leu Asp Glu 
            340                 345                 350         


Leu Leu Thr Val Ile Met Leu Tyr Trp Thr Thr Gly Thr Ile Thr Ser 
        355                 360                 365             


Ser Gln Arg Phe Tyr Lys Glu Asn Leu Gly Gln Gly Val Met Ala Asn 
    370                 375                 380                 


Lys His Glu Ala Ile Lys Val His Val Pro Thr Gly Phe Ala Ala Phe 
385                 390                 395                 400 


Pro Ser Glu Val Leu His Cys Pro Glu Lys Trp Val Lys Asn Lys Tyr 
                405                 410                 415     


Pro Lys Leu Ile Ser Tyr Ser Tyr Met Ala Arg Gly Gly His Phe Ala 
            420                 425                 430         


Ala Phe Glu Glu Pro Glu Leu Leu Ala Gln Asp Ile Arg Lys Phe Met 
        435                 440                 445             


Gly Leu Leu Glu Gln Gln 
    450                 


<210>  96
<211>  1302
<212>  PRT
<213>  Homo sapiens

<400>  96

Met Ala Leu Ala Gly Leu Cys Ala Leu Leu Ala Cys Cys Trp Gly Pro 
1               5                   10                  15      


Ala Ala Val Leu Ala Thr Ala Ala Gly Asp Val Asp Pro Ser Lys Glu 
            20                  25                  30          


Leu Glu Cys Lys Leu Lys Ser Ile Thr Val Ser Ala Leu Pro Phe Leu 
        35                  40                  45              


Arg Glu Asn Asp Leu Ser Ile Met His Ser Pro Ser Ala Ser Glu Pro 
    50                  55                  60                  


Lys Leu Leu Phe Ser Val Arg Asn Asp Phe Pro Gly Glu Met Val Val 
65                  70                  75                  80  


Val Asp Asp Leu Glu Asn Thr Glu Leu Pro Tyr Phe Val Leu Glu Ile 
                85                  90                  95      


Ser Gly Asn Thr Glu Asp Ile Pro Leu Val Arg Trp Arg Gln Gln Trp 
            100                 105                 110         


Leu Glu Asn Gly Thr Leu Leu Phe His Ile His His Gln Asp Gly Ala 
        115                 120                 125             


Pro Ser Leu Pro Gly Gln Asp Pro Thr Glu Glu Pro Gln His Glu Ser 
    130                 135                 140                 


Ala Glu Glu Glu Leu Arg Ile Leu His Ile Ser Val Met Gly Gly Met 
145                 150                 155                 160 


Ile Ala Leu Leu Leu Ser Ile Leu Cys Leu Val Met Ile Leu Tyr Thr 
                165                 170                 175     


Arg Arg Arg Trp Cys Lys Arg Arg Arg Val Pro Gln Pro Gln Lys Ser 
            180                 185                 190         


Ala Ser Ala Glu Ala Ala Asn Glu Ile His Tyr Ile Pro Ser Val Leu 
        195                 200                 205             


Ile Gly Gly His Gly Arg Glu Ser Leu Arg Asn Ala Arg Val Gln Gly 
    210                 215                 220                 


His Asn Ser Ser Gly Thr Leu Ser Ile Arg Glu Thr Pro Ile Leu Asp 
225                 230                 235                 240 


Gly Tyr Glu Tyr Asp Ile Thr Asp Leu Arg His His Leu Gln Arg Glu 
                245                 250                 255     


Cys Met Asn Gly Gly Glu Asp Phe Ala Ser Gln Val Thr Arg Thr Leu 
            260                 265                 270         


Asp Ser Leu Gln Gly Cys Asn Glu Lys Ser Gly Met Asp Leu Thr Pro 
        275                 280                 285             


Gly Ser Asp Asn Ala Lys Leu Ser Leu Met Asn Lys Tyr Lys Asp Asn 
    290                 295                 300                 


Ile Ile Ala Thr Ser Pro Val Asp Ser Asn His Gln Gln Ala Thr Leu 
305                 310                 315                 320 


Leu Ser His Thr Ser Ser Ser Gln Arg Lys Arg Ile Asn Asn Lys Ala 
                325                 330                 335     


Arg Ala Gly Ser Ala Phe Leu Asn Pro Glu Gly Asp Ser Gly Thr Glu 
            340                 345                 350         


Ala Glu Asn Asp Pro Gln Leu Thr Phe Tyr Thr Asp Pro Ser Arg Ser 
        355                 360                 365             


Arg Arg Arg Ser Arg Val Gly Ser Pro Arg Ser Pro Val Asn Lys Thr 
    370                 375                 380                 


Thr Leu Thr Leu Ile Ser Ile Thr Ser Cys Val Ile Gly Leu Val Cys 
385                 390                 395                 400 


Ser Ser His Val Asn Cys Pro Leu Val Val Lys Ile Thr Leu His Val 
                405                 410                 415     


Pro Glu His Leu Ile Ala Asp Gly Ser Arg Phe Ile Leu Leu Glu Gly 
            420                 425                 430         


Ser Gln Leu Asp Ala Ser Asp Trp Leu Asn Pro Ala Gln Val Val Leu 
        435                 440                 445             


Phe Ser Gln Gln Asn Ser Ser Gly Pro Trp Ala Met Asp Leu Cys Ala 
    450                 455                 460                 


Arg Arg Leu Leu Asp Pro Cys Glu His Gln Cys Asp Pro Glu Thr Gly 
465                 470                 475                 480 


Arg Arg Glu His Arg Ala Ala Gly Glu Cys Leu Cys Tyr Glu Gly Tyr 
                485                 490                 495     


Met Lys Asp Pro Val His Lys His Leu Cys Ile Arg Asn Glu Trp Gly 
            500                 505                 510         


Thr Asn Gln Gly Pro Trp Pro Tyr Thr Ile Phe Gln Arg Gly Phe Asp 
        515                 520                 525             


Leu Val Leu Gly Glu Gln Pro Ser Asp Lys Ile Phe Arg Phe Thr Tyr 
    530                 535                 540                 


Thr Leu Gly Glu Gly Met Trp Leu Pro Leu Ser Lys Ser Phe Val Ile 
545                 550                 555                 560 


Pro Pro Ala Glu Leu Ala Ile Asn Pro Ser Ala Lys Cys Lys Thr Asp 
                565                 570                 575     


Met Thr Val Met Glu Asp Ala Val Glu Val Arg Glu Glu Leu Met Thr 
            580                 585                 590         


Ser Ser Ser Phe Asp Ser Leu Glu Val Leu Leu Asp Ser Phe Gly Pro 
        595                 600                 605             


Val Arg Asp Cys Ser Lys Asp Asn Gly Gly Cys Ser Lys Asn Phe Arg 
    610                 615                 620                 


Cys Ile Ser Asp Arg Lys Leu Asp Ser Thr Gly Cys Val Cys Pro Ser 
625                 630                 635                 640 


Gly Leu Ser Pro Met Lys Asp Ser Ser Gly Cys Tyr Asp Arg His Ile 
                645                 650                 655     


Gly Val Asp Cys Ser Asp Gly Phe Asn Gly Gly Cys Glu Gln Leu Cys 
            660                 665                 670         


Leu Gln Gln Met Ala Pro Phe Pro Asp Asp Pro Thr Leu Tyr Asn Ile 
        675                 680                 685             


Leu Met Phe Cys Gly Cys Ile Glu Asp Tyr Lys Leu Gly Val Asp Gly 
    690                 695                 700                 


Arg Ser Cys Gln Leu Ile Thr Glu Thr Cys Pro Glu Gly Ser Asp Cys 
705                 710                 715                 720 


Gly Glu Ser Arg Glu Leu Pro Met Asn Gln Thr Leu Phe Gly Glu Met 
                725                 730                 735     


Phe Phe Gly Tyr Asn Asn His Ser Lys Glu Val Ala Ala Gly Gln Val 
            740                 745                 750         


Leu Lys Gly Thr Phe Arg Gln Asn Asn Phe Ala Arg Gly Leu Asp Gln 
        755                 760                 765             


Gln Leu Pro Asp Gly Leu Val Val Ala Thr Val Pro Leu Glu Asn Gln 
    770                 775                 780                 


Cys Leu Glu Glu Ile Ser Glu Pro Thr Pro Asp Pro Asp Phe Leu Thr 
785                 790                 795                 800 


Gly Met Val Asn Phe Ser Glu Val Ser Gly Tyr Pro Val Leu Gln His 
                805                 810                 815     


Trp Lys Val Arg Ser Val Met Tyr His Ile Lys Leu Asn Gln Val Ala 
            820                 825                 830         


Ile Ser Gln Ala Leu Ser Asn Ala Leu His Ser Leu Asp Gly Ala Thr 
        835                 840                 845             


Ser Arg Ala Asp Phe Val Ala Leu Leu Asp Gln Phe Gly Asn His Tyr 
    850                 855                 860                 


Ile Gln Glu Ala Ile Tyr Gly Phe Glu Glu Ser Cys Ser Ile Trp Tyr 
865                 870                 875                 880 


Pro Asn Lys Gln Val Gln Arg Arg Leu Trp Leu Glu Tyr Glu Asp Ile 
                885                 890                 895     


Ser Lys Gly Asn Ser Pro Ser Asp Glu Ser Glu Glu Arg Glu Arg Asp 
            900                 905                 910         


Pro Lys Val Leu Thr Phe Pro Glu Tyr Ile Thr Ser Leu Ser Asp Ser 
        915                 920                 925             


Gly Thr Lys His Met Ala Ala Gly Val Arg Met Glu Cys His Ser Lys 
    930                 935                 940                 


Gly Arg Cys Pro Ser Ser Cys Pro Leu Cys His Val Thr Ser Ser Pro 
945                 950                 955                 960 


Asp Thr Pro Ala Glu Pro Val Leu Leu Glu Val Thr Lys Ala Ala Pro 
                965                 970                 975     


Ile Tyr Glu Leu Val Thr Asn Asn Gln Thr Gln Arg Leu Leu Gln Glu 
            980                 985                 990         


Ala Thr Met Ser Ser Leu Trp Cys  Ser Gly Thr Gly Asp  Val Ile Glu 
        995                 1000                 1005             


Asp Trp  Cys Arg Cys Asp Ser  Thr Ala Phe Gly Ala  Asp Gly Leu 
    1010                 1015                 1020             


Pro Thr  Cys Ala Pro Leu Pro  Gln Pro Val Leu Arg  Leu Ser Thr 
    1025                 1030                 1035             


Val His  Glu Pro Ser Ser Thr  Leu Val Val Leu Glu  Trp Glu His 
    1040                 1045                 1050             


Ser Glu  Pro Pro Ile Gly Val  Gln Ile Val Asp Tyr  Leu Leu Arg 
    1055                 1060                 1065             


Gln Glu  Lys Val Thr Asp Arg  Met Asp His Ser Lys  Val Glu Thr 
    1070                 1075                 1080             


Glu Thr  Val Leu Ser Phe Val  Asp Asp Ile Ile Ser  Gly Ala Lys 
    1085                 1090                 1095             


Ser Pro  Cys Ala Met Pro Ser  Gln Val Pro Asp Lys  Gln Leu Thr 
    1100                 1105                 1110             


Thr Ile  Ser Leu Ile Ile Arg  Cys Leu Glu Pro Asp  Thr Ile Tyr 
    1115                 1120                 1125             


Met Phe  Thr Leu Trp Gly Val  Asp Asn Thr Gly Arg  Arg Ser Arg 
    1130                 1135                 1140             


Pro Ser  Asp Val Ile Val Lys  Thr Pro Cys Pro Val  Val Asp Asp 
    1145                 1150                 1155             


Val Lys  Ala Gln Glu Ile Ala  Asp Lys Ile Tyr Asn  Leu Phe Asn 
    1160                 1165                 1170             


Gly Tyr  Thr Ser Gly Lys Glu  Gln Gln Thr Ala Tyr  Asn Thr Leu 
    1175                 1180                 1185             


Leu Asp  Leu Gly Ser Pro Thr  Leu His Arg Val Leu  Tyr His Tyr 
    1190                 1195                 1200             


Asn Gln  His Tyr Glu Ser Phe  Gly Glu Phe Thr Trp  Arg Cys Glu 
    1205                 1210                 1215             


Asp Glu  Leu Gly Pro Arg Lys  Ala Gly Leu Ile Leu  Ser Gln Leu 
    1220                 1225                 1230             


Gly Asp  Leu Ser Ser Trp Cys  Asn Gly Leu Leu Gln  Glu Pro Lys 
    1235                 1240                 1245             


Ile Ser  Leu Arg Arg Ser Ser  Leu Lys Tyr Leu Gly  Cys Arg Tyr 
    1250                 1255                 1260             


Ser Glu  Ile Lys Pro Tyr Gly  Leu Asp Trp Ala Glu  Leu Ser Arg 
    1265                 1270                 1275             


Asp Leu  Arg Lys Thr Cys Glu  Glu Gln Thr Leu Ser  Ile Pro Tyr 
    1280                 1285                 1290             


Asn Asp  Tyr Gly Asp Ser Lys  Glu Ile 
    1295                 1300         


<210>  97
<211>  521
<212>  PRT
<213>  Homo sapiens

<400>  97

Met Leu Cys Ala Leu Leu Leu Leu Pro Ser Leu Leu Gly Ala Thr Arg 
1               5                   10                  15      


Ala Ser Pro Thr Ser Gly Pro Gln Glu Cys Ala Lys Gly Ser Thr Val 
            20                  25                  30          


Trp Cys Gln Asp Leu Gln Thr Ala Ala Arg Cys Gly Ala Val Gly Tyr 
        35                  40                  45              


Cys Gln Gly Ala Val Trp Asn Lys Pro Thr Ala Lys Ser Leu Pro Cys 
    50                  55                  60                  


Asp Val Cys Gln Asp Ile Ala Ala Ala Ala Gly Asn Gly Leu Asn Pro 
65                  70                  75                  80  


Asp Ala Thr Glu Ser Asp Ile Leu Ala Leu Val Met Lys Thr Cys Glu 
                85                  90                  95      


Trp Leu Pro Ser Gln Glu Ser Ser Ala Gly Cys Lys Trp Met Val Asp 
            100                 105                 110         


Ala His Ser Ser Ala Ile Leu Ser Met Leu Arg Gly Ala Pro Asp Ser 
        115                 120                 125             


Ala Pro Ala Gln Val Cys Thr Ala Leu Ser Leu Cys Glu Pro Leu Gln 
    130                 135                 140                 


Arg His Leu Ala Thr Leu Arg Pro Leu Ser Lys Glu Asp Thr Phe Glu 
145                 150                 155                 160 


Ala Val Ala Pro Phe Met Ala Asn Gly Pro Leu Thr Phe His Pro Arg 
                165                 170                 175     


Gln Ala Pro Glu Gly Ala Leu Cys Gln Asp Cys Val Arg Gln Val Ser 
            180                 185                 190         


Arg Leu Gln Glu Ala Val Arg Ser Asn Leu Thr Leu Ala Asp Leu Asn 
        195                 200                 205             


Ile Gln Glu Gln Cys Glu Ser Leu Gly Pro Gly Leu Ala Val Leu Cys 
    210                 215                 220                 


Lys Asn Tyr Leu Phe Gln Phe Phe Val Pro Ala Asp Gln Ala Leu Arg 
225                 230                 235                 240 


Leu Leu Pro Pro Gln Glu Leu Cys Arg Lys Gly Gly Phe Cys Glu Glu 
                245                 250                 255     


Leu Gly Ala Pro Ala Arg Leu Thr Gln Val Val Ala Met Asp Gly Val 
            260                 265                 270         


Pro Ser Leu Glu Leu Gly Leu Pro Arg Lys Gln Ser Glu Met Gln Met 
        275                 280                 285             


Lys Ala Gly Val Thr Cys Glu Val Cys Met Asn Val Val Gln Lys Leu 
    290                 295                 300                 


Asp His Trp Leu Met Ser Asn Ser Ser Glu Leu Met Ile Thr His Ala 
305                 310                 315                 320 


Leu Glu Arg Val Cys Ser Val Met Pro Ala Ser Ile Thr Lys Glu Cys 
                325                 330                 335     


Ile Ile Leu Val Asp Thr Tyr Ser Pro Ser Leu Val Gln Leu Val Ala 
            340                 345                 350         


Lys Ile Thr Pro Glu Lys Val Cys Lys Phe Ile Arg Leu Cys Gly Asn 
        355                 360                 365             


Arg Arg Arg Ala Arg Ala Val His Asp Ala Tyr Ala Ile Val Pro Ser 
    370                 375                 380                 


Pro Glu Trp Asp Ala Glu Asn Gln Gly Ser Phe Cys Asn Gly Cys Lys 
385                 390                 395                 400 


Arg Leu Leu Thr Val Ser Ser His Asn Leu Glu Ser Lys Ser Thr Lys 
                405                 410                 415     


Arg Asp Ile Leu Val Ala Phe Lys Gly Gly Cys Ser Ile Leu Pro Leu 
            420                 425                 430         


Pro Tyr Met Ile Gln Cys Lys His Phe Val Thr Gln Tyr Glu Pro Val 
        435                 440                 445             


Leu Ile Glu Ser Leu Lys Asp Met Met Asp Pro Val Ala Val Cys Lys 
    450                 455                 460                 


Lys Val Gly Ala Cys His Gly Pro Arg Thr Pro Leu Leu Gly Thr Asp 
465                 470                 475                 480 


Gln Cys Ala Leu Gly Pro Ser Phe Trp Cys Arg Ser Gln Glu Ala Ala 
                485                 490                 495     


Lys Leu Cys Asn Ala Val Gln His Cys Gln Lys His Val Trp Lys Glu 
            500                 505                 510         


Met His Leu His Ala Gly Glu His Ala 
        515                 520     


<210>  98
<211>  179
<212>  PRT
<213>  Homo sapiens

<400>  98

Met Leu Asn Val Ser Gly Leu Phe Val Leu Leu Cys Gly Leu Leu Val 
1               5                   10                  15      


Ser Ser Ser Ala Gln Glu Val Leu Ala Gly Val Ser Ser Gln Leu Leu 
            20                  25                  30          


Asn Asp Leu Thr Gln Gly Leu Leu Arg Ala Asp Phe Leu Pro Ser Leu 
        35                  40                  45              


Gln Thr Thr Gly Leu Gln Lys Pro Leu Ser Ser Ala Phe Asp Gly Val 
    50                  55                  60                  


Ser Gly Leu Leu Asp Ile Phe Gly Pro Pro Leu Thr Asn Glu Ile Asn 
65                  70                  75                  80  


Thr Val Ser Ile Gln Val Lys Asn Pro Gln Leu Leu His Val Ser Ile 
                85                  90                  95      


Glu Ser Thr Pro Gln Arg Lys Glu Ala Thr Val Gln Val Pro Phe Thr 
            100                 105                 110         


Ser Glu Leu Ile Val Gln Leu Leu Thr Met Lys Pro Phe Thr Ala Asn 
        115                 120                 125             


Met Gln Ser Asp Ile Lys Val Gln Ile Arg Leu Glu Lys Asn Val Gly 
    130                 135                 140                 


Gly Arg Tyr Glu Leu Ala Phe Gly Asn Cys Arg Leu Leu Pro Glu Ala 
145                 150                 155                 160 


Ile Trp Ile Gln Thr Gly Val Gln Leu Ala Pro Ala Gln Asn Leu Leu 
                165                 170                 175     


Trp Gln Thr 
            


<210>  99
<211>  353
<212>  PRT
<213>  Homo sapiens

<400>  99

Met Ala Ala Asp Gly Asp Trp Gln Asp Phe Tyr Glu Phe Gln Glu Pro 
1               5                   10                  15      


Ala Arg Ser Leu Leu Asp Gln Glu Asn Cys Asn Ala Ser Pro Glu Pro 
            20                  25                  30          


Gly Ala Glu Ala Gly Ala Glu Ala Gly Gly Gly Ala Asp Gly Phe Pro 
        35                  40                  45              


Ala Pro Ala Cys Ser Leu Glu Glu Lys Leu Ser Leu Cys Phe Arg Pro 
    50                  55                  60                  


Ser Asp Pro Gly Ala Glu Pro Pro Arg Thr Ala Val Arg Pro Ile Thr 
65                  70                  75                  80  


Glu Arg Ser Leu Leu Gln Gly Asp Glu Ile Trp Asn Ala Leu Thr Asp 
                85                  90                  95      


Asn Tyr Gly Asn Val Met Pro Val Asp Trp Lys Ser Ser His Thr Arg 
            100                 105                 110         


Thr Leu His Leu Leu Thr Leu Asn Leu Ser Glu Lys Gly Val Ser Asp 
        115                 120                 125             


Ser Leu Leu Phe Asp Thr Ser Asp Asp Glu Glu Leu Arg Glu Gln Leu 
    130                 135                 140                 


Asp Met His Ser Ile Ile Val Ser Cys Val Asn Asp Glu Pro Leu Phe 
145                 150                 155                 160 


Thr Ala Asp Gln Val Ile Glu Glu Ile Glu Glu Met Met Gln Glu Ser 
                165                 170                 175     


Pro Asp Pro Glu Asp Asp Glu Thr Pro Thr Gln Ser Asp Arg Leu Ser 
            180                 185                 190         


Met Leu Ser Gln Glu Ile Gln Thr Leu Lys Arg Ser Ser Thr Gly Ser 
        195                 200                 205             


Tyr Glu Glu Arg Val Lys Arg Leu Ser Val Ser Glu Leu Asn Glu Ile 
    210                 215                 220                 


Leu Glu Glu Ile Glu Thr Ala Ile Lys Glu Tyr Ser Glu Glu Leu Val 
225                 230                 235                 240 


Gln Gln Leu Ala Leu Arg Asp Glu Leu Glu Phe Glu Lys Glu Val Lys 
                245                 250                 255     


Asn Ser Phe Ile Ser Val Leu Ile Glu Val Gln Asn Lys Gln Lys Glu 
            260                 265                 270         


His Lys Glu Thr Ala Lys Lys Lys Lys Lys Leu Lys Asn Gly Ser Ser 
        275                 280                 285             


Gln Asn Gly Lys Asn Glu Arg Ser His Met Pro Gly Thr Tyr Leu Thr 
    290                 295                 300                 


Thr Val Ile Pro Tyr Glu Lys Lys Asn Gly Pro Pro Ser Val Glu Asp 
305                 310                 315                 320 


Leu Gln Ile Leu Thr Lys Ile Leu Arg Ala Met Lys Glu Asp Ser Glu 
                325                 330                 335     


Lys Val Pro Ser Leu Leu Thr Asp Tyr Ile Leu Lys Val Leu Cys Pro 
            340                 345                 350         


Thr 
    


<210>  100
<211>  713
<212>  PRT
<213>  Homo sapiens

<400>  100

Met Arg Leu Leu Val Ala Pro Leu Leu Leu Ala Trp Val Ala Gly Ala 
1               5                   10                  15      


Thr Ala Ala Val Pro Val Val Pro Trp His Val Pro Cys Pro Pro Gln 
            20                  25                  30          


Cys Ala Cys Gln Ile Arg Pro Trp Tyr Thr Pro Arg Ser Ser Tyr Arg 
        35                  40                  45              


Glu Ala Thr Thr Val Asp Cys Asn Asp Leu Phe Leu Thr Ala Val Pro 
    50                  55                  60                  


Pro Ala Leu Pro Ala Gly Thr Gln Thr Leu Leu Leu Gln Ser Asn Ser 
65                  70                  75                  80  


Ile Val Arg Val Asp Gln Ser Glu Leu Gly Tyr Leu Ala Asn Leu Thr 
                85                  90                  95      


Glu Leu Asp Leu Ser Gln Asn Ser Phe Ser Asp Ala Arg Asp Cys Asp 
            100                 105                 110         


Phe His Ala Leu Pro Gln Leu Leu Ser Leu His Leu Glu Glu Asn Gln 
        115                 120                 125             


Leu Thr Arg Leu Glu Asp His Ser Phe Ala Gly Leu Ala Ser Leu Gln 
    130                 135                 140                 


Glu Leu Tyr Leu Asn His Asn Gln Leu Tyr Arg Ile Ala Pro Arg Ala 
145                 150                 155                 160 


Phe Ser Gly Leu Ser Asn Leu Leu Arg Leu His Leu Asn Ser Asn Leu 
                165                 170                 175     


Leu Arg Ala Ile Asp Ser Arg Trp Phe Glu Met Leu Pro Asn Leu Glu 
            180                 185                 190         


Ile Leu Met Ile Gly Gly Asn Lys Val Asp Ala Ile Leu Asp Met Asn 
        195                 200                 205             


Phe Arg Pro Leu Ala Asn Leu Arg Ser Leu Val Leu Ala Gly Met Asn 
    210                 215                 220                 


Leu Arg Glu Ile Ser Asp Tyr Ala Leu Glu Gly Leu Gln Ser Leu Glu 
225                 230                 235                 240 


Ser Leu Ser Phe Tyr Asp Asn Gln Leu Ala Arg Val Pro Arg Arg Ala 
                245                 250                 255     


Leu Glu Gln Val Pro Gly Leu Lys Phe Leu Asp Leu Asn Lys Asn Pro 
            260                 265                 270         


Leu Gln Arg Val Gly Pro Gly Asp Phe Ala Asn Met Leu His Leu Lys 
        275                 280                 285             


Glu Leu Gly Leu Asn Asn Met Glu Glu Leu Val Ser Ile Asp Lys Phe 
    290                 295                 300                 


Ala Leu Val Asn Leu Pro Glu Leu Thr Lys Leu Asp Ile Thr Asn Asn 
305                 310                 315                 320 


Pro Arg Leu Ser Phe Ile His Pro Arg Ala Phe His His Leu Pro Gln 
                325                 330                 335     


Met Glu Thr Leu Met Leu Asn Asn Asn Ala Leu Ser Ala Leu His Gln 
            340                 345                 350         


Gln Thr Val Glu Ser Leu Pro Asn Leu Gln Glu Val Gly Leu His Gly 
        355                 360                 365             


Asn Pro Ile Arg Cys Asp Cys Val Ile Arg Trp Ala Asn Ala Thr Gly 
    370                 375                 380                 


Thr Arg Val Arg Phe Ile Glu Pro Gln Ser Thr Leu Cys Ala Glu Pro 
385                 390                 395                 400 


Pro Asp Leu Gln Arg Leu Pro Val Arg Glu Val Pro Phe Arg Glu Met 
                405                 410                 415     


Thr Asp His Cys Leu Pro Leu Ile Ser Pro Arg Ser Phe Pro Pro Ser 
            420                 425                 430         


Leu Gln Val Ala Ser Gly Glu Ser Met Val Leu His Cys Arg Ala Leu 
        435                 440                 445             


Ala Glu Pro Glu Pro Glu Ile Tyr Trp Val Thr Pro Ala Gly Leu Arg 
    450                 455                 460                 


Leu Thr Pro Ala His Ala Gly Arg Arg Tyr Arg Val Tyr Pro Glu Gly 
465                 470                 475                 480 


Thr Leu Glu Leu Arg Arg Val Thr Ala Glu Glu Ala Gly Leu Tyr Thr 
                485                 490                 495     


Cys Val Ala Gln Asn Leu Val Gly Ala Asp Thr Lys Thr Val Ser Val 
            500                 505                 510         


Val Val Gly Arg Ala Leu Leu Gln Pro Gly Arg Asp Glu Gly Gln Gly 
        515                 520                 525             


Leu Glu Leu Arg Val Gln Glu Thr His Pro Tyr His Ile Leu Leu Ser 
    530                 535                 540                 


Trp Val Thr Pro Pro Asn Thr Val Ser Thr Asn Leu Thr Trp Ser Ser 
545                 550                 555                 560 


Ala Ser Ser Leu Arg Gly Gln Gly Ala Thr Ala Leu Ala Arg Leu Pro 
                565                 570                 575     


Arg Gly Thr His Ser Tyr Asn Ile Thr Arg Leu Leu Gln Ala Thr Glu 
            580                 585                 590         


Tyr Trp Ala Cys Leu Gln Val Ala Phe Ala Asp Ala His Thr Gln Leu 
        595                 600                 605             


Ala Cys Val Trp Ala Arg Thr Lys Glu Ala Thr Ser Cys His Arg Ala 
    610                 615                 620                 


Leu Gly Asp Arg Pro Gly Leu Ile Ala Ile Leu Ala Leu Ala Val Leu 
625                 630                 635                 640 


Leu Leu Ala Ala Gly Leu Ala Ala His Leu Gly Thr Gly Gln Pro Arg 
                645                 650                 655     


Lys Gly Val Gly Gly Arg Arg Pro Leu Pro Pro Ala Trp Ala Phe Trp 
            660                 665                 670         


Gly Trp Ser Ala Pro Ser Val Arg Val Val Ser Ala Pro Leu Val Leu 
        675                 680                 685             


Pro Trp Asn Pro Gly Arg Lys Leu Pro Arg Ser Ser Glu Gly Glu Thr 
    690                 695                 700                 


Leu Leu Pro Pro Leu Ser Gln Asn Ser 
705                 710             


<210>  101
<211>  5890
<212>  PRT
<213>  Homo sapiens

<400>  101

Met Glu Lys Glu Glu Thr Thr Arg Glu Leu Leu Leu Pro Asn Trp Gln 
1               5                   10                  15      


Gly Ser Gly Ser His Gly Leu Thr Ile Ala Gln Arg Asp Asp Gly Val 
            20                  25                  30          


Phe Val Gln Glu Val Thr Gln Asn Ser Pro Ala Ala Arg Thr Gly Val 
        35                  40                  45              


Val Lys Glu Gly Asp Gln Ile Val Gly Ala Thr Ile Tyr Phe Asp Asn 
    50                  55                  60                  


Leu Gln Ser Gly Glu Val Thr Gln Leu Leu Asn Thr Met Gly His His 
65                  70                  75                  80  


Thr Val Gly Leu Lys Leu His Arg Lys Gly Asp Arg Ser Pro Glu Pro 
                85                  90                  95      


Gly Gln Thr Trp Thr Arg Glu Val Phe Ser Ser Cys Ser Ser Glu Val 
            100                 105                 110         


Val Leu Ser Gly Asp Asp Glu Glu Tyr Gln Arg Ile Tyr Thr Thr Lys 
        115                 120                 125             


Ile Lys Pro Arg Leu Lys Ser Glu Asp Gly Val Glu Gly Asp Leu Gly 
    130                 135                 140                 


Glu Thr Gln Ser Arg Thr Ile Thr Val Thr Arg Arg Val Thr Ala Tyr 
145                 150                 155                 160 


Thr Val Asp Val Thr Gly Arg Glu Gly Ala Lys Asp Ile Asp Ile Ser 
                165                 170                 175     


Ser Pro Glu Phe Lys Ile Lys Ile Pro Arg His Glu Leu Thr Glu Ile 
            180                 185                 190         


Ser Asn Val Asp Val Glu Thr Gln Ser Gly Lys Thr Val Ile Arg Leu 
        195                 200                 205             


Pro Ser Gly Ser Gly Ala Ala Ser Pro Thr Gly Ser Ala Val Asp Ile 
    210                 215                 220                 


Arg Ala Gly Ala Ile Ser Ala Ser Gly Pro Glu Leu Gln Gly Ala Gly 
225                 230                 235                 240 


His Ser Lys Leu Gln Val Thr Met Pro Gly Ile Lys Val Gly Gly Ser 
                245                 250                 255     


Gly Val Asn Val Asn Ala Lys Gly Leu Asp Leu Gly Gly Arg Gly Gly 
            260                 265                 270         


Val Gln Val Pro Ala Val Asp Ile Ser Ser Ser Leu Gly Gly Arg Ala 
        275                 280                 285             


Val Glu Val Gln Gly Pro Ser Leu Glu Ser Gly Asp His Gly Lys Ile 
    290                 295                 300                 


Lys Phe Pro Thr Met Lys Val Pro Lys Phe Gly Val Ser Thr Gly Arg 
305                 310                 315                 320 


Glu Gly Gln Thr Pro Lys Ala Gly Leu Arg Val Ser Ala Pro Glu Val 
                325                 330                 335     


Ser Val Gly His Lys Gly Gly Lys Pro Gly Leu Thr Ile Gln Ala Pro 
            340                 345                 350         


Gln Leu Glu Val Ser Val Pro Ser Ala Asn Ile Glu Gly Leu Glu Gly 
        355                 360                 365             


Lys Leu Lys Gly Pro Gln Ile Thr Gly Pro Ser Leu Glu Gly Asp Leu 
    370                 375                 380                 


Gly Leu Lys Gly Ala Lys Pro Gln Gly His Ile Gly Val Asp Ala Ser 
385                 390                 395                 400 


Ala Pro Gln Ile Gly Gly Ser Ile Thr Gly Pro Ser Val Glu Val Gln 
                405                 410                 415     


Ala Pro Asp Ile Asp Val Gln Gly Pro Gly Ser Lys Leu Asn Val Pro 
            420                 425                 430         


Lys Met Lys Val Pro Lys Phe Ser Val Ser Gly Ala Lys Gly Glu Glu 
        435                 440                 445             


Thr Gly Ile Asp Val Thr Leu Pro Thr Gly Glu Val Thr Val Pro Gly 
    450                 455                 460                 


Val Ser Gly Asp Val Ser Leu Pro Glu Ile Ala Thr Gly Gly Leu Glu 
465                 470                 475                 480 


Gly Lys Met Lys Gly Thr Lys Val Lys Thr Pro Glu Met Ile Ile Gln 
                485                 490                 495     


Lys Pro Lys Ile Ser Met Gln Asp Val Asp Leu Ser Leu Gly Ser Pro 
            500                 505                 510         


Lys Leu Lys Gly Asp Ile Lys Val Ser Ala Pro Gly Val Gln Gly Asp 
        515                 520                 525             


Val Lys Gly Pro Gln Val Ala Leu Lys Gly Ser Arg Val Asp Ile Glu 
    530                 535                 540                 


Thr Pro Asn Leu Glu Gly Thr Leu Thr Gly Pro Arg Leu Gly Ser Pro 
545                 550                 555                 560 


Ser Gly Lys Thr Gly Thr Cys Arg Ile Ser Met Ser Glu Val Asp Leu 
                565                 570                 575     


Asn Val Ala Ala Pro Lys Val Lys Gly Gly Val Asp Val Thr Leu Pro 
            580                 585                 590         


Arg Val Glu Gly Lys Val Lys Val Pro Glu Val Asp Val Arg Gly Pro 
        595                 600                 605             


Lys Val Asp Val Ser Ala Pro Asp Val Glu Ala His Gly Pro Glu Trp 
    610                 615                 620                 


Asn Leu Lys Met Pro Lys Met Lys Met Pro Thr Phe Ser Thr Pro Gly 
625                 630                 635                 640 


Ala Lys Gly Glu Gly Pro Asp Val His Met Thr Leu Pro Lys Gly Asp 
                645                 650                 655     


Ile Ser Ile Ser Gly Pro Lys Val Asn Val Glu Ala Pro Asp Val Asn 
            660                 665                 670         


Leu Glu Gly Leu Gly Gly Lys Leu Lys Gly Pro Asp Val Lys Leu Pro 
        675                 680                 685             


Asp Met Ser Val Lys Thr Pro Lys Ile Ser Met Pro Asp Val Asp Leu 
    690                 695                 700                 


His Val Lys Gly Thr Lys Val Lys Gly Glu Tyr Asp Val Thr Val Pro 
705                 710                 715                 720 


Lys Leu Glu Gly Glu Leu Lys Gly Pro Lys Val Asp Ile Asp Ala Pro 
                725                 730                 735     


Asp Val Asp Val His Gly Pro Asp Trp His Leu Lys Met Pro Lys Met 
            740                 745                 750         


Lys Met Pro Lys Phe Ser Val Pro Gly Phe Lys Ala Glu Gly Pro Glu 
        755                 760                 765             


Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Ile Ser Gly Pro Lys 
    770                 775                 780                 


Ile Asp Val Thr Ala Pro Asp Val Ser Ile Glu Glu Pro Glu Gly Lys 
785                 790                 795                 800 


Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Val Pro 
                805                 810                 815     


Lys Ile Ser Met Pro Asp Val Asp Leu His Leu Lys Gly Pro Asn Val 
            820                 825                 830         


Lys Gly Glu Tyr Asp Val Thr Met Pro Lys Val Glu Ser Glu Ile Lys 
        835                 840                 845             


Val Pro Asp Val Glu Leu Lys Ser Ala Lys Met Asp Ile Asp Val Pro 
    850                 855                 860                 


Asp Val Glu Val Gln Gly Pro Asp Trp His Leu Lys Met Pro Lys Met 
865                 870                 875                 880 


Lys Met Pro Lys Phe Ser Met Pro Gly Phe Lys Ala Glu Gly Pro Glu 
                885                 890                 895     


Val Asp Val Asn Leu Pro Lys Ala Asp Val Asp Ile Ser Gly Pro Lys 
            900                 905                 910         


Val Gly Val Glu Val Pro Asp Val Asn Ile Glu Gly Pro Glu Gly Lys 
        915                 920                 925             


Leu Lys Gly Pro Lys Phe Lys Met Pro Glu Met Asn Ile Lys Ala Pro 
    930                 935                 940                 


Lys Ile Ser Met Pro Asp Val Asp Leu His Met Lys Gly Pro Lys Val 
945                 950                 955                 960 


Lys Gly Glu Tyr Asp Met Thr Val Pro Lys Leu Glu Gly Asp Leu Lys 
                965                 970                 975     


Gly Pro Lys Val Asp Val Ser Ala Pro Asp Val Glu Met Gln Gly Pro 
            980                 985                 990         


Asp Trp Asn Leu Lys Met Pro Lys  Ile Lys Met Pro Lys  Phe Ser Met 
        995                 1000                 1005             


Pro Ser  Leu Lys Gly Glu Gly  Pro Glu Phe Asp Val  Asn Leu Ser 
    1010                 1015                 1020             


Lys Ala  Asn Val Asp Ile Ser  Ala Pro Lys Val Asp  Thr Asn Ala 
    1025                 1030                 1035             


Pro Asp  Leu Ser Leu Glu Gly  Pro Glu Gly Lys Leu  Lys Gly Pro 
    1040                 1045                 1050             


Lys Phe  Lys Met Pro Glu Met  His Phe Arg Ala Pro  Lys Met Ser 
    1055                 1060                 1065             


Leu Pro  Asp Val Asp Leu Asp  Leu Lys Gly Pro Lys  Met Lys Gly 
    1070                 1075                 1080             


Asn Val  Asp Ile Ser Ala Pro  Lys Ile Glu Gly Glu  Met Gln Val 
    1085                 1090                 1095             


Pro Asp  Val Asp Ile Arg Gly  Pro Lys Val Asp Ile  Lys Ala Pro 
    1100                 1105                 1110             


Asp Val  Glu Gly Gln Gly Leu  Asp Trp Ser Leu Lys  Ile Pro Lys 
    1115                 1120                 1125             


Met Lys  Met Pro Lys Phe Ser  Met Pro Ser Leu Lys  Gly Glu Gly 
    1130                 1135                 1140             


Pro Glu  Val Asp Val Asn Leu  Pro Lys Ala Asp Val  Val Val Ser 
    1145                 1150                 1155             


Gly Pro  Lys Val Asp Ile Glu  Ala Pro Asp Val Ser  Leu Glu Gly 
    1160                 1165                 1170             


Pro Glu  Gly Lys Leu Lys Gly  Pro Lys Phe Lys Met  Pro Glu Met 
    1175                 1180                 1185             


His Phe  Lys Thr Pro Lys Ile  Ser Met Pro Asp Val  Asp Leu His 
    1190                 1195                 1200             


Leu Lys  Gly Pro Lys Val Lys  Gly Asp Val Asp Val  Ser Val Pro 
    1205                 1210                 1215             


Lys Val  Glu Gly Glu Met Lys  Val Pro Asp Val Glu  Ile Lys Gly 
    1220                 1225                 1230             


Pro Lys  Met Asp Ile Asp Ala  Pro Asp Val Glu Val  Gln Gly Pro 
    1235                 1240                 1245             


Asp Trp  His Leu Lys Met Pro  Lys Met Lys Met Pro  Lys Phe Ser 
    1250                 1255                 1260             


Met Pro  Gly Phe Lys Gly Glu  Gly Arg Glu Val Asp  Val Asn Leu 
    1265                 1270                 1275             


Pro Lys  Ala Asp Ile Asp Val  Ser Gly Pro Lys Val  Asp Val Glu 
    1280                 1285                 1290             


Val Pro  Asp Val Ser Leu Glu  Gly Pro Glu Gly Lys  Leu Lys Gly 
    1295                 1300                 1305             


Pro Lys  Phe Lys Met Pro Glu  Met His Phe Lys Ala  Pro Lys Ile 
    1310                 1315                 1320             


Ser Met  Pro Asp Val Asp Leu  Asn Leu Lys Gly Pro  Lys Leu Lys 
    1325                 1330                 1335             


Gly Asp  Val Asp Val Ser Leu  Pro Glu Val Glu Gly  Glu Met Lys 
    1340                 1345                 1350             


Val Pro  Asp Val Asp Ile Lys  Gly Pro Lys Val Asp  Ile Ser Ala 
    1355                 1360                 1365             


Pro Asp  Val Asp Val His Gly  Pro Asp Trp His Leu  Lys Met Pro 
    1370                 1375                 1380             


Lys Val  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Gly Glu 
    1385                 1390                 1395             


Gly Pro  Glu Val Asp Val Lys  Leu Pro Lys Ala Asp  Val Asp Val 
    1400                 1405                 1410             


Ser Gly  Pro Lys Met Asp Ala  Glu Val Pro Asp Val  Asn Ile Glu 
    1415                 1420                 1425             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    1430                 1435                 1440             


Met Ser  Ile Lys Pro Gln Lys  Ile Ser Ile Pro Asp  Val Gly Leu 
    1445                 1450                 1455             


His Leu  Lys Gly Pro Lys Met  Lys Gly Asp Tyr Asp  Val Thr Val 
    1460                 1465                 1470             


Pro Lys  Val Glu Gly Glu Ile  Lys Ala Pro Asp Val  Asp Ile Lys 
    1475                 1480                 1485             


Gly Pro  Lys Val Asp Ile Asn  Ala Pro Asp Val Glu  Val His Gly 
    1490                 1495                 1500             


Pro Asp  Trp His Leu Lys Met  Pro Lys Val Lys Met  Pro Lys Phe 
    1505                 1510                 1515             


Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro Glu Val  Asp Met Asn 
    1520                 1525                 1530             


Leu Pro  Lys Ala Asp Leu Gly  Val Ser Gly Pro Lys  Val Asp Ile 
    1535                 1540                 1545             


Asp Val  Pro Asp Val Asn Leu  Glu Ala Pro Glu Gly  Lys Leu Lys 
    1550                 1555                 1560             


Gly Pro  Lys Phe Lys Met Pro  Ser Met Asn Ile Gln  Thr His Lys 
    1565                 1570                 1575             


Ile Ser  Met Pro Asp Val Gly  Leu Asn Leu Lys Ala  Pro Lys Leu 
    1580                 1585                 1590             


Lys Thr  Asp Val Asp Val Ser  Leu Pro Lys Val Glu  Gly Asp Leu 
    1595                 1600                 1605             


Lys Gly  Pro Glu Ile Asp Val  Lys Ala Pro Lys Met  Asp Val Asn 
    1610                 1615                 1620             


Val Gly  Asp Ile Asp Ile Glu  Gly Pro Glu Gly Lys  Leu Lys Gly 
    1625                 1630                 1635             


Pro Lys  Phe Lys Met Pro Glu  Met His Phe Lys Ala  Pro Lys Ile 
    1640                 1645                 1650             


Ser Met  Pro Asp Val Asp Leu  His Leu Lys Gly Pro  Lys Val Lys 
    1655                 1660                 1665             


Gly Asp  Met Asp Val Ser Val  Pro Lys Val Glu Gly  Glu Met Lys 
    1670                 1675                 1680             


Val Pro  Asp Val Asp Ile Lys  Gly Pro Lys Val Asp  Ile Asp Ala 
    1685                 1690                 1695             


Pro Asp  Val Glu Val His Asp  Pro Asp Trp His Leu  Lys Met Pro 
    1700                 1705                 1710             


Lys Met  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Ala Glu 
    1715                 1720                 1725             


Gly Pro  Glu Val Asp Val Asn  Leu Pro Lys Ala Asp  Ile Asp Val 
    1730                 1735                 1740             


Ser Gly  Pro Ser Val Asp Thr  Asp Ala Pro Asp Leu  Asp Ile Glu 
    1745                 1750                 1755             


Gly Pro  Glu Gly Lys Leu Lys  Gly Ser Lys Phe Lys  Met Pro Lys 
    1760                 1765                 1770             


Leu Asn  Ile Lys Ala Pro Lys  Val Ser Met Pro Asp  Val Asp Leu 
    1775                 1780                 1785             


Asn Leu  Lys Gly Pro Lys Leu  Lys Gly Glu Ile Asp  Ala Ser Val 
    1790                 1795                 1800             


Pro Glu  Leu Glu Gly Asp Leu  Arg Gly Pro Gln Val  Asp Val Lys 
    1805                 1810                 1815             


Gly Pro  Phe Val Glu Ala Glu  Val Pro Asp Val Asp  Leu Glu Cys 
    1820                 1825                 1830             


Pro Asp  Ala Lys Leu Lys Gly  Pro Lys Phe Lys Met  Pro Glu Met 
    1835                 1840                 1845             


His Phe  Lys Ala Pro Lys Ile  Ser Met Pro Asp Val  Asp Leu His 
    1850                 1855                 1860             


Leu Lys  Gly Pro Lys Val Lys  Gly Asp Ala Asp Val  Ser Val Pro 
    1865                 1870                 1875             


Lys Leu  Glu Gly Asp Leu Thr  Gly Pro Ser Val Gly  Val Glu Val 
    1880                 1885                 1890             


Pro Asp  Val Glu Leu Glu Cys  Pro Asp Ala Lys Leu  Lys Gly Pro 
    1895                 1900                 1905             


Lys Phe  Lys Met Pro Asp Met  His Phe Lys Ala Pro  Lys Ile Ser 
    1910                 1915                 1920             


Met Pro  Asp Val Asp Leu His  Leu Lys Gly Pro Lys  Val Lys Gly 
    1925                 1930                 1935             


Asp Val  Asp Val Ser Val Pro  Lys Leu Glu Gly Asp  Leu Thr Gly 
    1940                 1945                 1950             


Pro Ser  Val Gly Val Glu Val  Pro Asp Val Glu Leu  Glu Cys Pro 
    1955                 1960                 1965             


Asp Ala  Lys Leu Lys Gly Pro  Lys Phe Lys Met Pro  Glu Met His 
    1970                 1975                 1980             


Phe Lys  Thr Pro Lys Ile Ser  Met Pro Asp Val Asp  Leu His Leu 
    1985                 1990                 1995             


Lys Gly  Pro Lys Val Lys Gly  Asp Met Asp Val Ser  Val Pro Lys 
    2000                 2005                 2010             


Val Glu  Gly Glu Met Lys Val  Pro Asp Val Asp Ile  Lys Gly Pro 
    2015                 2020                 2025             


Lys Met  Asp Ile Asp Ala Pro  Asp Val Asp Val His  Gly Pro Asp 
    2030                 2035                 2040             


Trp His  Leu Lys Met Pro Lys  Met Lys Met Pro Lys  Phe Ser Met 
    2045                 2050                 2055             


Pro Gly  Phe Lys Ala Glu Gly  Pro Glu Val Asp Val  Asn Leu Pro 
    2060                 2065                 2070             


Lys Ala  Asp Val Val Val Ser  Gly Pro Lys Val Asp  Val Glu Val 
    2075                 2080                 2085             


Pro Asp  Val Ser Leu Glu Gly  Pro Glu Gly Lys Leu  Lys Gly Pro 
    2090                 2095                 2100             


Lys Leu  Lys Met Pro Glu Met  His Phe Lys Ala Pro  Lys Ile Ser 
    2105                 2110                 2115             


Met Pro  Asp Val Asp Leu His  Leu Lys Gly Pro Lys  Val Lys Gly 
    2120                 2125                 2130             


Asp Val  Asp Val Ser Leu Pro  Lys Leu Glu Gly Asp  Leu Thr Gly 
    2135                 2140                 2145             


Pro Ser  Val Asp Val Glu Val  Pro Asp Val Glu Leu  Glu Cys Pro 
    2150                 2155                 2160             


Asp Ala  Lys Leu Lys Gly Pro  Lys Phe Lys Met Pro  Glu Met His 
    2165                 2170                 2175             


Phe Lys  Thr Pro Lys Ile Ser  Met Pro Asp Val Asn  Leu Asn Leu 
    2180                 2185                 2190             


Lys Gly  Pro Lys Val Lys Gly  Asp Met Asp Val Ser  Val Pro Lys 
    2195                 2200                 2205             


Val Glu  Gly Glu Met Lys Val  Pro Asp Val Asp Ile  Arg Gly Pro 
    2210                 2215                 2220             


Lys Val  Asp Ile Asp Ala Pro  Asp Val Asp Val His  Gly Pro Asp 
    2225                 2230                 2235             


Trp His  Leu Lys Met Pro Lys  Met Lys Met Pro Lys  Phe Ser Met 
    2240                 2245                 2250             


Pro Gly  Phe Lys Gly Glu Gly  Pro Glu Val Asp Val  Asn Leu Pro 
    2255                 2260                 2265             


Lys Ala  Asp Val Asp Val Ser  Gly Pro Lys Val Asp  Val Glu Val 
    2270                 2275                 2280             


Pro Asp  Val Ser Leu Glu Gly  Pro Glu Gly Lys Leu  Lys Gly Pro 
    2285                 2290                 2295             


Lys Phe  Lys Met Pro Glu Met  His Phe Lys Thr Pro  Lys Ile Ser 
    2300                 2305                 2310             


Met Pro  Asp Val Asp Phe Asn  Leu Lys Gly Pro Lys  Ile Lys Gly 
    2315                 2320                 2325             


Asp Val  Asp Val Ser Ala Pro  Lys Leu Glu Gly Glu  Leu Lys Gly 
    2330                 2335                 2340             


Pro Glu  Leu Asp Val Lys Gly  Pro Lys Leu Asp Ala  Asp Met Pro 
    2345                 2350                 2355             


Glu Val  Ala Val Glu Gly Pro  Asn Gly Lys Trp Lys  Thr Pro Lys 
    2360                 2365                 2370             


Phe Lys  Met Pro Asp Met His  Phe Lys Ala Pro Lys  Ile Ser Met 
    2375                 2380                 2385             


Pro Asp  Leu Asp Leu His Leu  Lys Ser Pro Lys Ala  Lys Gly Glu 
    2390                 2395                 2400             


Val Asp  Val Asp Val Pro Lys  Leu Glu Gly Asp Leu  Lys Gly Pro 
    2405                 2410                 2415             


His Val  Asp Val Ser Gly Pro  Asp Ile Asp Ile Glu  Gly Pro Glu 
    2420                 2425                 2430             


Gly Lys  Leu Lys Gly Pro Lys  Phe Lys Met Pro Asp  Met His Phe 
    2435                 2440                 2445             


Lys Ala  Pro Asn Ile Ser Met  Pro Asp Val Asp Leu  Asn Leu Lys 
    2450                 2455                 2460             


Gly Pro  Lys Ile Lys Gly Asp  Val Asp Val Ser Val  Pro Glu Val 
    2465                 2470                 2475             


Glu Gly  Lys Leu Glu Val Pro  Asp Met Asn Ile Arg  Gly Pro Lys 
    2480                 2485                 2490             


Val Asp  Val Asn Ala Pro Asp  Val Gln Ala Pro Asp  Trp His Leu 
    2495                 2500                 2505             


Lys Met  Pro Lys Met Lys Met  Pro Lys Phe Ser Met  Pro Gly Phe 
    2510                 2515                 2520             


Lys Ala  Glu Gly Pro Glu Val  Asp Val Asn Leu Pro  Lys Ala Asp 
    2525                 2530                 2535             


Val Asp  Ile Ser Gly Pro Lys  Val Asp Ile Glu Gly  Pro Asp Val 
    2540                 2545                 2550             


Asn Ile  Glu Gly Pro Glu Gly  Lys Leu Lys Gly Pro  Lys Leu Lys 
    2555                 2560                 2565             


Met Pro  Glu Met Asn Ile Lys  Ala Pro Lys Ile Ser  Met Pro Asp 
    2570                 2575                 2580             


Phe Asp  Leu His Leu Lys Gly  Pro Lys Val Lys Gly  Asp Val Asp 
    2585                 2590                 2595             


Val Ser  Leu Pro Lys Val Glu  Gly Asp Leu Lys Gly  Pro Glu Val 
    2600                 2605                 2610             


Asp Ile  Lys Gly Pro Lys Val  Asp Ile Asn Ala Pro  Asp Val Gly 
    2615                 2620                 2625             


Val Gln  Gly Pro Asp Trp His  Leu Lys Met Pro Lys  Val Lys Met 
    2630                 2635                 2640             


Pro Lys  Phe Ser Met Pro Gly  Phe Lys Gly Glu Gly  Pro Asp Gly 
    2645                 2650                 2655             


Asp Val  Lys Leu Pro Lys Ala  Asp Ile Asp Val Ser  Gly Pro Lys 
    2660                 2665                 2670             


Val Asp  Ile Glu Gly Pro Asp  Val Asn Ile Glu Gly  Pro Glu Gly 
    2675                 2680                 2685             


Lys Leu  Lys Gly Pro Lys Phe  Lys Met Pro Glu Met  Asn Ile Lys 
    2690                 2695                 2700             


Ala Pro  Lys Ile Ser Met Pro  Asp Ile Asp Leu Asn  Leu Lys Gly 
    2705                 2710                 2715             


Pro Lys  Val Lys Gly Asp Val  Asp Val Ser Leu Pro  Lys Val Glu 
    2720                 2725                 2730             


Gly Asp  Leu Lys Gly Pro Glu  Val Asp Ile Lys Gly  Pro Lys Val 
    2735                 2740                 2745             


Asp Ile  Asp Ala Pro Asp Val  Asp Val His Gly Pro  Asp Trp His 
    2750                 2755                 2760             


Leu Lys  Met Pro Lys Ile Lys  Met Pro Lys Ile Ser  Met Pro Gly 
    2765                 2770                 2775             


Phe Lys  Gly Glu Gly Pro Asp  Val Asp Val Asn Leu  Pro Lys Ala 
    2780                 2785                 2790             


Asp Ile  Asp Val Ser Gly Pro  Lys Val Asp Val Glu  Cys Pro Asp 
    2795                 2800                 2805             


Val Asn  Ile Glu Gly Pro Glu  Gly Lys Trp Lys Ser  Pro Lys Phe 
    2810                 2815                 2820             


Lys Met  Pro Glu Met His Phe  Lys Thr Pro Lys Ile  Ser Met Pro 
    2825                 2830                 2835             


Asp Ile  Asp Leu Asn Leu Thr  Gly Pro Lys Ile Lys  Gly Asp Val 
    2840                 2845                 2850             


Asp Val  Thr Gly Pro Lys Val  Glu Gly Asp Leu Lys  Gly Pro Glu 
    2855                 2860                 2865             


Val Asp  Leu Lys Gly Pro Lys  Val Asp Ile Asp Val  Pro Asp Val 
    2870                 2875                 2880             


Asn Val  Gln Gly Pro Asp Trp  His Leu Lys Met Pro  Lys Met Lys 
    2885                 2890                 2895             


Met Pro  Lys Phe Ser Met Pro  Gly Phe Lys Ala Glu  Gly Pro Glu 
    2900                 2905                 2910             


Val Asp  Val Asn Leu Pro Lys  Ala Asp Val Asp Val  Ser Gly Pro 
    2915                 2920                 2925             


Lys Val  Asp Val Glu Gly Pro  Asp Val Asn Ile Glu  Gly Pro Glu 
    2930                 2935                 2940             


Gly Lys  Leu Lys Gly Pro Lys  Phe Lys Met Pro Glu  Met Asn Ile 
    2945                 2950                 2955             


Lys Ala  Pro Lys Ile Pro Met  Pro Asp Phe Asp Leu  His Leu Lys 
    2960                 2965                 2970             


Gly Pro  Lys Val Lys Gly Asp  Val Asp Ile Ser Leu  Pro Lys Val 
    2975                 2980                 2985             


Glu Gly  Asp Leu Lys Gly Pro  Glu Val Asp Ile Arg  Gly Pro Gln 
    2990                 2995                 3000             


Val Asp  Ile Asp Val Pro Asp  Val Gly Val Gln Gly  Pro Asp Trp 
    3005                 3010                 3015             


His Leu  Lys Met Pro Lys Val  Lys Met Pro Lys Phe  Ser Met Pro 
    3020                 3025                 3030             


Gly Phe  Lys Gly Glu Gly Pro  Asp Val Asp Val Asn  Leu Pro Lys 
    3035                 3040                 3045             


Ala Asp  Leu Asp Val Ser Gly  Pro Lys Val Asp Ile  Asp Val Pro 
    3050                 3055                 3060             


Asp Val  Asn Ile Glu Gly Pro  Glu Gly Lys Leu Lys  Gly Pro Lys 
    3065                 3070                 3075             


Phe Lys  Met Pro Glu Met Asn  Ile Lys Ala Pro Lys  Ile Ser Met 
    3080                 3085                 3090             


Pro Asp  Ile Asp Leu Asn Leu  Lys Gly Pro Lys Val  Lys Gly Asp 
    3095                 3100                 3105             


Met Asp  Val Ser Leu Pro Lys  Val Glu Gly Asp Met  Lys Val Pro 
    3110                 3115                 3120             


Asp Val  Asp Ile Lys Gly Pro  Lys Val Asp Ile Asn  Ala Pro Asp 
    3125                 3130                 3135             


Val Asp  Val Gln Gly Pro Asp  Trp His Leu Lys Met  Pro Lys Ile 
    3140                 3145                 3150             


Lys Met  Pro Lys Ile Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro 
    3155                 3160                 3165             


Glu Val  Asp Val Asn Leu Pro  Lys Ala Asp Leu Asp  Val Ser Gly 
    3170                 3175                 3180             


Pro Lys  Val Asp Val Asp Val  Pro Asp Val Asn Ile  Glu Gly Pro 
    3185                 3190                 3195             


Asp Ala  Lys Leu Lys Gly Pro  Lys Phe Lys Met Pro  Glu Met Asn 
    3200                 3205                 3210             


Ile Lys  Ala Pro Lys Ile Ser  Met Pro Asp Leu Asp  Leu Asn Leu 
    3215                 3220                 3225             


Lys Gly  Pro Lys Met Lys Gly  Glu Val Asp Val Ser  Leu Ala Asn 
    3230                 3235                 3240             


Val Glu  Gly Asp Leu Lys Gly  Pro Ala Leu Asp Ile  Lys Gly Pro 
    3245                 3250                 3255             


Lys Ile  Asp Val Asp Ala Pro  Asp Ile Asp Ile His  Gly Pro Asp 
    3260                 3265                 3270             


Ala Lys  Leu Lys Gly Pro Lys  Leu Lys Met Pro Asp  Met His Val 
    3275                 3280                 3285             


Asn Met  Pro Lys Ile Ser Met  Pro Glu Ile Asp Leu  Asn Leu Lys 
    3290                 3295                 3300             


Gly Ser  Lys Leu Lys Gly Asp  Val Asp Val Ser Gly  Pro Lys Leu 
    3305                 3310                 3315             


Glu Gly  Asp Ile Lys Ala Pro  Ser Leu Asp Ile Lys  Gly Pro Glu 
    3320                 3325                 3330             


Val Asp  Val Ser Gly Pro Lys  Leu Asn Ile Glu Gly  Lys Ser Lys 
    3335                 3340                 3345             


Lys Ser  Arg Phe Lys Leu Pro  Lys Phe Asn Phe Ser  Gly Ser Lys 
    3350                 3355                 3360             


Val Gln  Thr Pro Glu Val Asp  Val Lys Gly Lys Lys  Pro Asp Ile 
    3365                 3370                 3375             


Asp Ile  Thr Gly Pro Lys Val  Asp Ile Asn Ala Pro  Asp Val Glu 
    3380                 3385                 3390             


Val Gln  Gly Lys Val Lys Gly  Ser Lys Phe Lys Met  Pro Phe Leu 
    3395                 3400                 3405             


Ser Ile  Ser Ser Pro Lys Val  Ser Met Pro Asp Val  Glu Leu Asn 
    3410                 3415                 3420             


Leu Lys  Ser Pro Lys Val Lys  Gly Asp Leu Asp Ile  Ala Gly Pro 
    3425                 3430                 3435             


Asn Leu  Glu Gly Asp Phe Lys  Gly Pro Lys Val Asp  Ile Lys Ala 
    3440                 3445                 3450             


Pro Glu  Val Asn Leu Asn Ala  Pro Asp Val Asp Val  His Gly Pro 
    3455                 3460                 3465             


Asp Trp  Asn Leu Lys Met Pro  Lys Met Lys Met Pro  Lys Phe Ser 
    3470                 3475                 3480             


Val Ser  Gly Leu Lys Ala Glu  Gly Pro Asp Val Ala  Val Asp Leu 
    3485                 3490                 3495             


Pro Lys  Gly Asp Ile Asn Ile  Glu Gly Pro Ser Met  Asn Ile Glu 
    3500                 3505                 3510             


Gly Pro  Asp Leu Asn Val Glu  Gly Pro Glu Gly Gly  Leu Lys Gly 
    3515                 3520                 3525             


Pro Lys  Phe Lys Met Pro Asp  Met Asn Ile Lys Ala  Pro Lys Ile 
    3530                 3535                 3540             


Ser Met  Pro Asp Ile Asp Leu  Asn Leu Lys Gly Pro  Lys Val Lys 
    3545                 3550                 3555             


Gly Asp  Val Asp Ile Ser Leu  Pro Lys Leu Glu Gly  Asp Leu Lys 
    3560                 3565                 3570             


Gly Pro  Glu Val Asp Ile Lys  Gly Pro Lys Val Asp  Ile Asn Ala 
    3575                 3580                 3585             


Pro Asp  Val Asp Val His Gly  Pro Asp Trp His Leu  Lys Met Pro 
    3590                 3595                 3600             


Lys Val  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Gly Glu 
    3605                 3610                 3615             


Gly Pro  Glu Val Asp Val Thr  Leu Pro Lys Ala Asp  Ile Asp Ile 
    3620                 3625                 3630             


Ser Gly  Pro Asn Val Asp Val  Asp Val Pro Asp Val  Asn Ile Glu 
    3635                 3640                 3645             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    3650                 3655                 3660             


Met Asn  Ile Lys Ala Pro Lys  Ile Ser Met Pro Asp  Phe Asp Leu 
    3665                 3670                 3675             


Asn Leu  Lys Gly Pro Lys Met  Lys Gly Asp Val Val  Val Ser Leu 
    3680                 3685                 3690             


Pro Lys  Val Glu Gly Asp Leu  Lys Gly Pro Glu Val  Asp Ile Lys 
    3695                 3700                 3705             


Gly Pro  Lys Val Asp Ile Asp  Thr Pro Asp Ile Asn  Ile Glu Gly 
    3710                 3715                 3720             


Ser Glu  Gly Lys Phe Lys Gly  Pro Lys Phe Lys Ile  Pro Glu Met 
    3725                 3730                 3735             


His Leu  Lys Ala Pro Lys Ile  Ser Met Pro Asp Ile  Asp Leu Asn 
    3740                 3745                 3750             


Leu Lys  Gly Pro Lys Val Lys  Gly Asp Val Asp Val  Ser Leu Pro 
    3755                 3760                 3765             


Lys Met  Glu Gly Asp Leu Lys  Gly Pro Glu Val Asp  Ile Lys Gly 
    3770                 3775                 3780             


Pro Lys  Val Asp Ile Asn Ala  Pro Asp Val Asp Val  Gln Gly Pro 
    3785                 3790                 3795             


Asp Trp  His Leu Lys Met Pro  Lys Val Lys Met Pro  Lys Phe Ser 
    3800                 3805                 3810             


Met Pro  Gly Phe Lys Gly Glu  Gly Pro Asp Val Asp  Val Asn Leu 
    3815                 3820                 3825             


Pro Lys  Ala Asp Leu Asp Val  Ser Gly Pro Lys Val  Asp Ile Asp 
    3830                 3835                 3840             


Val Pro  Asp Val Asn Ile Glu  Gly Pro Glu Gly Lys  Leu Lys Gly 
    3845                 3850                 3855             


Pro Lys  Phe Lys Met Pro Glu  Met Asn Ile Lys Ala  Pro Lys Ile 
    3860                 3865                 3870             


Ser Met  Pro Asp Ile Asp Leu  Asn Leu Lys Gly Pro  Lys Val Lys 
    3875                 3880                 3885             


Gly Asp  Met Asp Val Ser Leu  Pro Lys Val Glu Gly  Asp Met Gln 
    3890                 3895                 3900             


Val Pro  Asp Leu Asp Ile Lys  Gly Pro Lys Val Asp  Ile Asn Ala 
    3905                 3910                 3915             


Pro Asp  Val Asp Val Arg Gly  Pro Asp Trp His Leu  Lys Met Pro 
    3920                 3925                 3930             


Lys Ile  Lys Met Pro Lys Ile  Ser Met Pro Gly Phe  Lys Gly Glu 
    3935                 3940                 3945             


Gly Pro  Glu Val Asp Val Asn  Leu Pro Lys Ala Asp  Leu Asp Val 
    3950                 3955                 3960             


Ser Gly  Pro Lys Val Asp Val  Asp Val Pro Asp Val  Asn Ile Glu 
    3965                 3970                 3975             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    3980                 3985                 3990             


Met Asn  Ile Lys Ala Pro Lys  Ile Ser Met Pro Asp  Phe Asp Leu 
    3995                 4000                 4005             


His Leu  Lys Gly Pro Lys Val  Lys Gly Asp Val Asp  Val Ser Leu 
    4010                 4015                 4020             


Pro Lys  Met Glu Gly Asp Leu  Lys Ala Pro Glu Val  Asp Ile Lys 
    4025                 4030                 4035             


Gly Pro  Lys Val Asp Ile Asp  Ala Pro Asp Val Asp  Val His Gly 
    4040                 4045                 4050             


Pro Asp  Trp His Leu Lys Met  Pro Lys Val Lys Met  Pro Lys Phe 
    4055                 4060                 4065             


Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro Glu Val  Asp Val Asn 
    4070                 4075                 4080             


Leu Pro  Lys Ala Asp Ile Asp  Val Ser Gly Pro Lys  Val Asp Ile 
    4085                 4090                 4095             


Asp Thr  Pro Asp Ile Asp Ile  His Gly Pro Glu Gly  Lys Leu Lys 
    4100                 4105                 4110             


Gly Pro  Lys Phe Lys Met Pro  Asp Leu His Leu Lys  Ala Pro Lys 
    4115                 4120                 4125             


Ile Ser  Met Pro Glu Val Asp  Leu Asn Leu Lys Gly  Pro Lys Met 
    4130                 4135                 4140             


Lys Gly  Asp Val Asp Val Ser  Leu Pro Lys Val Glu  Gly Asp Leu 
    4145                 4150                 4155             


Lys Gly  Pro Glu Val Asp Ile  Lys Gly Pro Lys Val  Asp Ile Asp 
    4160                 4165                 4170             


Val Pro  Asp Val Asp Val Gln  Gly Pro Asp Trp His  Leu Lys Met 
    4175                 4180                 4185             


Pro Lys  Val Lys Met Pro Lys  Phe Ser Met Pro Gly  Phe Lys Gly 
    4190                 4195                 4200             


Glu Gly  Pro Asp Val Asp Val  Asn Leu Pro Lys Ala  Asp Leu Asp 
    4205                 4210                 4215             


Val Ser  Gly Pro Lys Val Asp  Ile Asp Val Pro Asp  Val Asn Ile 
    4220                 4225                 4230             


Glu Gly  Pro Asp Ala Lys Leu  Lys Gly Pro Lys Phe  Lys Met Pro 
    4235                 4240                 4245             


Glu Met  Asn Ile Lys Ala Pro  Lys Ile Ser Met Pro  Asp Phe Asp 
    4250                 4255                 4260             


Leu His  Leu Lys Gly Pro Lys  Val Lys Gly Asp Val  Asp Val Ser 
    4265                 4270                 4275             


Leu Pro  Lys Val Glu Gly Asp  Leu Lys Gly Pro Glu  Val Asp Ile 
    4280                 4285                 4290             


Lys Gly  Pro Lys Val Asp Ile  Asp Ala Pro Asp Val  Asp Val His 
    4295                 4300                 4305             


Gly Pro  Asp Trp His Leu Lys  Met Pro Lys Val Lys  Met Pro Lys 
    4310                 4315                 4320             


Phe Ser  Met Pro Gly Phe Lys  Gly Glu Gly Pro Asp  Val Asp Val 
    4325                 4330                 4335             


Thr Leu  Pro Lys Ala Asp Ile  Glu Ile Ser Gly Pro  Lys Val Asp 
    4340                 4345                 4350             


Ile Asp  Ala Pro Asp Val Ser  Ile Glu Gly Pro Asp  Ala Lys Leu 
    4355                 4360                 4365             


Lys Gly  Pro Lys Phe Lys Met  Pro Glu Met Asn Ile  Lys Ala Pro 
    4370                 4375                 4380             


Lys Ile  Ser Met Pro Asp Ile  Asp Phe Asn Leu Lys  Gly Pro Lys 
    4385                 4390                 4395             


Val Lys  Gly Asp Val Asp Val  Ser Leu Pro Lys Val  Glu Gly Asp 
    4400                 4405                 4410             


Leu Lys  Gly Pro Glu Ile Asp  Ile Lys Gly Pro Ser  Leu Asp Ile 
    4415                 4420                 4425             


Asp Thr  Pro Asp Val Asn Ile  Glu Gly Pro Glu Gly  Lys Leu Lys 
    4430                 4435                 4440             


Gly Pro  Lys Phe Lys Met Pro  Glu Met Asn Ile Lys  Ala Pro Lys 
    4445                 4450                 4455             


Ile Ser  Met Pro Asp Phe Asp  Leu His Leu Lys Gly  Pro Lys Val 
    4460                 4465                 4470             


Lys Gly  Asp Val Asp Val Ser  Leu Pro Lys Val Glu  Ser Asp Leu 
    4475                 4480                 4485             


Lys Gly  Pro Glu Val Asp Ile  Glu Gly Pro Glu Gly  Lys Leu Lys 
    4490                 4495                 4500             


Gly Pro  Lys Phe Lys Met Pro  Asp Val His Phe Lys  Ser Pro Gln 
    4505                 4510                 4515             


Ile Ser  Met Ser Asp Ile Asp  Leu Asn Leu Lys Gly  Pro Lys Ile 
    4520                 4525                 4530             


Lys Gly  Asp Met Asp Ile Ser  Val Pro Lys Leu Glu  Gly Asp Leu 
    4535                 4540                 4545             


Lys Gly  Pro Lys Val Asp Val  Lys Gly Pro Lys Val  Gly Ile Asp 
    4550                 4555                 4560             


Thr Pro  Asp Ile Asp Ile His  Gly Pro Glu Gly Lys  Leu Lys Gly 
    4565                 4570                 4575             


Pro Lys  Phe Lys Met Pro Asp  Leu His Leu Lys Ala  Pro Lys Ile 
    4580                 4585                 4590             


Ser Met  Pro Glu Val Asp Leu  Asn Leu Lys Gly Pro  Lys Val Lys 
    4595                 4600                 4605             


Gly Asp  Met Asp Ile Ser Leu  Pro Lys Val Glu Gly  Asp Leu Lys 
    4610                 4615                 4620             


Gly Pro  Glu Val Asp Ile Arg  Asp Pro Lys Val Asp  Ile Asp Val 
    4625                 4630                 4635             


Pro Asp  Val Asp Val Gln Gly  Pro Asp Trp His Leu  Lys Met Pro 
    4640                 4645                 4650             


Lys Val  Lys Met Pro Lys Phe  Ser Met Pro Gly Phe  Lys Gly Glu 
    4655                 4660                 4665             


Gly Pro  Asp Val Asp Val Asn  Leu Pro Lys Ala Asp  Ile Asp Val 
    4670                 4675                 4680             


Ser Gly  Pro Lys Val Asp Val  Asp Val Pro Asp Val  Asn Ile Glu 
    4685                 4690                 4695             


Gly Pro  Asp Ala Lys Leu Lys  Gly Pro Lys Phe Lys  Met Pro Glu 
    4700                 4705                 4710             


Met Ser  Ile Lys Ala Pro Lys  Ile Ser Met Pro Asp  Ile Asp Leu 
    4715                 4720                 4725             


Asn Leu  Lys Gly Pro Lys Val  Lys Gly Asp Val Asp  Val Thr Leu 
    4730                 4735                 4740             


Pro Lys  Val Glu Gly Asp Leu  Lys Gly Pro Glu Ala  Asp Ile Lys 
    4745                 4750                 4755             


Gly Pro  Lys Val Asp Ile Asn  Thr Pro Asp Val Asp  Val His Gly 
    4760                 4765                 4770             


Pro Asp  Trp His Leu Lys Met  Pro Lys Val Lys Met  Pro Lys Phe 
    4775                 4780                 4785             


Ser Met  Pro Gly Phe Lys Gly  Glu Gly Pro Asp Val  Asp Val Ser 
    4790                 4795                 4800             


Leu Pro  Lys Ala Asp Ile Asp  Val Ser Gly Pro Lys  Val Asp Val 
    4805                 4810                 4815             


Asp Ile  Pro Asp Val Asn Ile  Glu Gly Pro Asp Ala  Lys Leu Lys 
    4820                 4825                 4830             


Gly Pro  Lys Phe Lys Met Pro  Glu Ile Asn Ile Lys  Ala Pro Lys 
    4835                 4840                 4845             


Ile Ser  Ile Pro Asp Val Asp  Leu Asp Leu Lys Gly  Pro Lys Val 
    4850                 4855                 4860             


Lys Gly  Asp Phe Asp Val Ser  Val Pro Lys Val Glu  Gly Thr Leu 
    4865                 4870                 4875             


Lys Gly  Pro Glu Val Asp Leu  Lys Gly Pro Arg Leu  Asp Phe Glu 
    4880                 4885                 4890             


Gly Pro  Asp Ala Lys Leu Ser  Gly Pro Ser Leu Lys  Met Pro Ser 
    4895                 4900                 4905             


Leu Glu  Ile Ser Ala Pro Lys  Val Thr Ala Pro Asp  Val Asp Leu 
    4910                 4915                 4920             


His Leu  Lys Ala Pro Lys Ile  Gly Phe Ser Gly Pro  Lys Leu Glu 
    4925                 4930                 4935             


Gly Gly  Glu Val Asp Leu Lys  Gly Pro Lys Val Glu  Ala Pro Ser 
    4940                 4945                 4950             


Leu Asp  Val His Met Asp Ser  Pro Asp Ile Asn Ile  Glu Gly Pro 
    4955                 4960                 4965             


Asp Val  Lys Ile Pro Lys Phe  Lys Lys Pro Lys Phe  Gly Phe Gly 
    4970                 4975                 4980             


Ala Lys  Ser Pro Lys Ala Asp  Ile Lys Ser Pro Ser  Leu Asp Val 
    4985                 4990                 4995             


Thr Val  Pro Glu Ala Glu Leu  Asn Leu Glu Thr Pro  Glu Ile Ser 
    5000                 5005                 5010             


Val Gly  Gly Lys Gly Lys Lys  Ser Lys Phe Lys Met  Pro Lys Ile 
    5015                 5020                 5025             


His Met  Ser Gly Pro Lys Ile  Lys Ala Lys Lys Gln  Gly Phe Asp 
    5030                 5035                 5040             


Leu Asn  Val Pro Gly Gly Glu  Ile Asp Ala Ser Leu  Lys Ala Pro 
    5045                 5050                 5055             


Asp Val  Asp Val Asn Ile Ala  Gly Pro Asp Ala Ala  Leu Lys Val 
    5060                 5065                 5070             


Asp Val  Lys Ser Pro Lys Thr  Lys Lys Thr Met Phe  Gly Lys Met 
    5075                 5080                 5085             


Tyr Phe  Pro Asp Val Glu Phe  Asp Ile Lys Ser Pro  Lys Phe Lys 
    5090                 5095                 5100             


Ala Glu  Ala Pro Leu Pro Ser  Pro Lys Leu Glu Gly  Glu Leu Gln 
    5105                 5110                 5115             


Ala Pro  Asp Leu Glu Leu Ser  Leu Pro Ala Ile His  Val Glu Gly 
    5120                 5125                 5130             


Leu Asp  Ile Lys Ala Lys Ala  Pro Lys Val Lys Met  Pro Asp Val 
    5135                 5140                 5145             


Asp Ile  Ser Val Pro Lys Ile  Glu Gly Asp Leu Lys  Gly Pro Lys 
    5150                 5155                 5160             


Val Gln  Ala Asn Leu Gly Ala  Pro Asp Ile Asn Ile  Glu Gly Leu 
    5165                 5170                 5175             


Asp Ala  Lys Val Lys Thr Pro  Ser Phe Gly Ile Ser  Ala Pro Gln 
    5180                 5185                 5190             


Val Ser  Ile Pro Asp Val Asn  Val Asn Leu Lys Gly  Pro Lys Ile 
    5195                 5200                 5205             


Lys Gly  Asp Val Pro Ser Val  Gly Leu Glu Gly Pro  Asp Val Asp 
    5210                 5215                 5220             


Leu Gln  Gly Pro Glu Ala Lys  Ile Lys Phe Pro Lys  Phe Ser Met 
    5225                 5230                 5235             


Pro Lys  Ile Gly Ile Pro Gly  Val Lys Met Glu Gly  Gly Gly Ala 
    5240                 5245                 5250             


Glu Val  His Ala Gln Leu Pro  Ser Leu Glu Gly Asp  Leu Arg Gly 
    5255                 5260                 5265             


Pro Asp  Val Lys Leu Glu Gly  Pro Asp Val Ser Leu  Lys Gly Pro 
    5270                 5275                 5280             


Gly Val  Asp Leu Pro Ser Val  Asn Leu Ser Met Pro  Lys Val Ser 
    5285                 5290                 5295             


Gly Pro  Asp Leu Asp Leu Asn  Leu Lys Gly Pro Ser  Leu Lys Gly 
    5300                 5305                 5310             


Asp Leu  Asp Ala Ser Val Pro  Ser Met Lys Val His  Ala Pro Gly 
    5315                 5320                 5325             


Leu Asn  Leu Ser Gly Val Gly  Gly Lys Met Gln Val  Gly Gly Asp 
    5330                 5335                 5340             


Gly Val  Lys Val Pro Gly Ile  Asp Ala Thr Thr Lys  Leu Asn Val 
    5345                 5350                 5355             


Gly Ala  Pro Asp Val Thr Leu  Arg Gly Pro Ser Leu  Gln Gly Asp 
    5360                 5365                 5370             


Leu Ala  Val Ser Gly Asp Ile  Lys Cys Pro Lys Val  Ser Val Gly 
    5375                 5380                 5385             


Ala Pro  Asp Leu Ser Leu Glu  Ala Ser Glu Gly Ser  Ile Lys Leu 
    5390                 5395                 5400             


Pro Lys  Met Lys Leu Pro Gln  Phe Gly Ile Ser Thr  Pro Gly Ser 
    5405                 5410                 5415             


Asp Leu  His Val Asn Ala Lys  Gly Pro Gln Val Ser  Gly Glu Leu 
    5420                 5425                 5430             


Lys Gly  Pro Gly Val Asp Val  Asn Leu Lys Gly Pro  Arg Ile Ser 
    5435                 5440                 5445             


Ala Pro  Asn Val Asp Phe Asn  Leu Glu Gly Pro Lys  Val Lys Gly 
    5450                 5455                 5460             


Ser Leu  Gly Ala Thr Gly Glu  Ile Lys Gly Pro Thr  Val Gly Gly 
    5465                 5470                 5475             


Gly Leu  Pro Gly Ile Gly Val  Gln Gly Leu Glu Gly  Asn Leu Gln 
    5480                 5485                 5490             


Met Pro  Gly Ile Lys Ser Ser  Gly Cys Asp Val Asn  Leu Pro Gly 
    5495                 5500                 5505             


Val Asn  Val Lys Leu Pro Thr  Gly Gln Ile Ser Gly  Pro Glu Ile 
    5510                 5515                 5520             


Lys Gly  Gly Leu Lys Gly Ser  Glu Val Gly Phe His  Gly Ala Ala 
    5525                 5530                 5535             


Pro Asp  Ile Ser Val Lys Gly  Pro Ala Phe Asn Met  Ala Ser Pro 
    5540                 5545                 5550             


Glu Ser  Asp Phe Gly Ile Asn  Leu Lys Gly Pro Lys  Ile Lys Gly 
    5555                 5560                 5565             


Gly Ala  Asp Val Ser Gly Gly  Val Ser Ala Pro Asp  Ile Ser Leu 
    5570                 5575                 5580             


Gly Glu  Gly His Leu Ser Val  Lys Gly Ser Gly Gly  Glu Trp Lys 
    5585                 5590                 5595             


Gly Pro  Gln Val Ser Ser Ala  Leu Asn Leu Asp Thr  Ser Lys Phe 
    5600                 5605                 5610             


Ala Gly  Gly Leu His Phe Ser  Gly Pro Lys Val Glu  Gly Gly Val 
    5615                 5620                 5625             


Lys Gly  Gly Gln Ile Gly Leu  Gln Ala Pro Gly Leu  Ser Val Ser 
    5630                 5635                 5640             


Gly Pro  Gln Gly His Leu Glu  Ser Gly Ser Gly Lys  Val Thr Phe 
    5645                 5650                 5655             


Pro Lys  Met Lys Ile Pro Lys  Phe Thr Phe Ser Gly  Arg Glu Leu 
    5660                 5665                 5670             


Val Gly  Arg Glu Met Gly Val  Asp Val His Phe Pro  Lys Ala Glu 
    5675                 5680                 5685             


Ala Ser  Ile Gln Ala Gly Ala  Gly Asp Gly Glu Trp  Glu Glu Ser 
    5690                 5695                 5700             


Glu Val  Lys Leu Lys Lys Ser  Lys Ile Lys Met Pro  Lys Phe Asn 
    5705                 5710                 5715             


Phe Ser  Lys Pro Lys Gly Lys  Gly Gly Val Thr Gly  Ser Pro Glu 
    5720                 5725                 5730             


Ala Ser  Ile Ser Gly Ser Lys  Gly Asp Leu Lys Ser  Ser Lys Ala 
    5735                 5740                 5745             


Ser Leu  Gly Ser Leu Glu Gly  Glu Ala Glu Ala Glu  Ala Ser Ser 
    5750                 5755                 5760             


Pro Lys  Gly Lys Phe Ser Leu  Phe Lys Ser Lys Lys  Pro Arg His 
    5765                 5770                 5775             


Arg Ser  Asn Ser Phe Ser Asp  Glu Arg Glu Phe Ser  Gly Pro Ser 
    5780                 5785                 5790             


Thr Pro  Thr Gly Thr Leu Glu  Phe Glu Gly Gly Glu  Val Ser Leu 
    5795                 5800                 5805             


Glu Gly  Gly Lys Val Lys Gly  Lys His Gly Lys Leu  Lys Phe Gly 
    5810                 5815                 5820             


Thr Phe  Gly Gly Leu Gly Ser  Lys Ser Lys Gly His  Tyr Glu Val 
    5825                 5830                 5835             


Thr Gly  Ser Asp Asp Glu Thr  Gly Lys Leu Gln Gly  Ser Gly Val 
    5840                 5845                 5850             


Ser Leu  Ala Ser Lys Lys Ser  Arg Leu Ser Ser Ser  Ser Ser Asn 
    5855                 5860                 5865             


Asp Ser  Gly Asn Lys Val Gly  Ile Gln Leu Pro Glu  Val Glu Leu 
    5870                 5875                 5880             


Ser Val  Ser Thr Lys Lys Glu  
    5885                 5890 


<210>  102
<211>  1257
<212>  PRT
<213>  Homo sapiens

<400>  102

Met Val Val Ala Leu Arg Tyr Val Trp Pro Leu Leu Leu Cys Ser Pro 
1               5                   10                  15      


Cys Leu Leu Ile Gln Ile Pro Glu Glu Tyr Glu Gly His His Val Met 
            20                  25                  30          


Glu Pro Pro Val Ile Thr Glu Gln Ser Pro Arg Arg Leu Val Val Phe 
        35                  40                  45              


Pro Thr Asp Asp Ile Ser Leu Lys Cys Glu Ala Ser Gly Lys Pro Glu 
    50                  55                  60                  


Val Gln Phe Arg Trp Thr Arg Asp Gly Val His Phe Lys Pro Lys Glu 
65                  70                  75                  80  


Glu Leu Gly Val Thr Val Tyr Gln Ser Pro His Ser Gly Ser Phe Thr 
                85                  90                  95      


Ile Thr Gly Asn Asn Ser Asn Phe Ala Gln Arg Phe Gln Gly Ile Tyr 
            100                 105                 110         


Arg Cys Phe Ala Ser Asn Lys Leu Gly Thr Ala Met Ser His Glu Ile 
        115                 120                 125             


Arg Leu Met Ala Glu Gly Ala Pro Lys Trp Pro Lys Glu Thr Val Lys 
    130                 135                 140                 


Pro Val Glu Val Glu Glu Gly Glu Ser Val Val Leu Pro Cys Asn Pro 
145                 150                 155                 160 


Pro Pro Ser Ala Glu Pro Leu Arg Ile Tyr Trp Met Asn Ser Lys Ile 
                165                 170                 175     


Leu His Ile Lys Gln Asp Glu Arg Val Thr Met Gly Gln Asn Gly Asn 
            180                 185                 190         


Leu Tyr Phe Ala Asn Val Leu Thr Ser Asp Asn His Ser Asp Tyr Ile 
        195                 200                 205             


Cys His Ala His Phe Pro Gly Thr Arg Thr Ile Ile Gln Lys Glu Pro 
    210                 215                 220                 


Ile Asp Leu Arg Val Lys Ala Thr Asn Ser Met Ile Asp Arg Lys Pro 
225                 230                 235                 240 


Arg Leu Leu Phe Pro Thr Asn Ser Ser Ser His Leu Val Ala Leu Gln 
                245                 250                 255     


Gly Gln Pro Leu Val Leu Glu Cys Ile Ala Glu Gly Phe Pro Thr Pro 
            260                 265                 270         


Thr Ile Lys Trp Leu Arg Pro Ser Gly Pro Met Pro Ala Asp Arg Val 
        275                 280                 285             


Thr Tyr Gln Asn His Asn Lys Thr Leu Gln Leu Leu Lys Val Gly Glu 
    290                 295                 300                 


Glu Asp Asp Gly Glu Tyr Arg Cys Leu Ala Glu Asn Ser Leu Gly Ser 
305                 310                 315                 320 


Ala Arg His Ala Tyr Tyr Val Thr Val Glu Ala Ala Pro Tyr Trp Leu 
                325                 330                 335     


His Lys Pro Gln Ser His Leu Tyr Gly Pro Gly Glu Thr Ala Arg Leu 
            340                 345                 350         


Asp Cys Gln Val Gln Gly Arg Pro Gln Pro Glu Val Thr Trp Arg Ile 
        355                 360                 365             


Asn Gly Ile Pro Val Glu Glu Leu Ala Lys Asp Gln Lys Tyr Arg Ile 
    370                 375                 380                 


Gln Arg Gly Ala Leu Ile Leu Ser Asn Val Gln Pro Ser Asp Thr Met 
385                 390                 395                 400 


Val Thr Gln Cys Glu Ala Arg Asn Arg His Gly Leu Leu Leu Ala Asn 
                405                 410                 415     


Ala Tyr Ile Tyr Val Val Gln Leu Pro Ala Lys Ile Leu Thr Ala Asp 
            420                 425                 430         


Asn Gln Thr Tyr Met Ala Val Gln Gly Ser Thr Ala Tyr Leu Leu Cys 
        435                 440                 445             


Lys Ala Phe Gly Ala Pro Val Pro Ser Val Gln Trp Leu Asp Glu Asp 
    450                 455                 460                 


Gly Thr Thr Val Leu Gln Asp Glu Arg Phe Phe Pro Tyr Ala Asn Gly 
465                 470                 475                 480 


Thr Leu Gly Ile Arg Asp Leu Gln Ala Asn Asp Thr Gly Arg Tyr Phe 
                485                 490                 495     


Cys Leu Ala Ala Asn Asp Gln Asn Asn Val Thr Ile Met Ala Asn Leu 
            500                 505                 510         


Lys Val Lys Asp Ala Thr Gln Ile Thr Gln Gly Pro Arg Ser Thr Ile 
        515                 520                 525             


Glu Lys Lys Gly Ser Arg Val Thr Phe Thr Cys Gln Ala Ser Phe Asp 
    530                 535                 540                 


Pro Ser Leu Gln Pro Ser Ile Thr Trp Arg Gly Asp Gly Arg Asp Leu 
545                 550                 555                 560 


Gln Glu Leu Gly Asp Ser Asp Lys Tyr Phe Ile Glu Asp Gly Arg Leu 
                565                 570                 575     


Val Ile His Ser Leu Asp Tyr Ser Asp Gln Gly Asn Tyr Ser Cys Val 
            580                 585                 590         


Ala Ser Thr Glu Leu Asp Val Val Glu Ser Arg Ala Gln Leu Leu Val 
        595                 600                 605             


Val Gly Ser Pro Gly Pro Val Pro Arg Leu Val Leu Ser Asp Leu His 
    610                 615                 620                 


Leu Leu Thr Gln Ser Gln Val Arg Val Ser Trp Ser Pro Ala Glu Asp 
625                 630                 635                 640 


His Asn Ala Pro Ile Glu Lys Tyr Asp Ile Glu Phe Glu Asp Lys Glu 
                645                 650                 655     


Met Ala Pro Glu Lys Trp Tyr Ser Leu Gly Lys Val Pro Gly Asn Gln 
            660                 665                 670         


Thr Ser Thr Thr Leu Lys Leu Ser Pro Tyr Val His Tyr Thr Phe Arg 
        675                 680                 685             


Val Thr Ala Ile Asn Lys Tyr Gly Pro Gly Glu Pro Ser Pro Val Ser 
    690                 695                 700                 


Glu Thr Val Val Thr Pro Glu Ala Ala Pro Glu Lys Asn Pro Val Asp 
705                 710                 715                 720 


Val Lys Gly Glu Gly Asn Glu Thr Thr Asn Met Val Ile Thr Trp Lys 
                725                 730                 735     


Pro Leu Arg Trp Met Asp Trp Asn Ala Pro Gln Val Gln Tyr Arg Val 
            740                 745                 750         


Gln Trp Arg Pro Gln Gly Thr Arg Gly Pro Trp Gln Glu Gln Ile Val 
        755                 760                 765             


Ser Asp Pro Phe Leu Val Val Ser Asn Thr Ser Thr Phe Val Pro Tyr 
    770                 775                 780                 


Glu Ile Lys Val Gln Ala Val Asn Ser Gln Gly Lys Gly Pro Glu Pro 
785                 790                 795                 800 


Gln Val Thr Ile Gly Tyr Ser Gly Glu Asp Tyr Pro Gln Ala Ile Pro 
                805                 810                 815     


Glu Leu Glu Gly Ile Glu Ile Leu Asn Ser Ser Ala Val Leu Val Lys 
            820                 825                 830         


Trp Arg Pro Val Asp Leu Ala Gln Val Lys Gly His Leu Arg Gly Tyr 
        835                 840                 845             


Asn Val Thr Tyr Trp Arg Glu Gly Ser Gln Arg Lys His Ser Lys Arg 
    850                 855                 860                 


His Ile His Lys Asp His Val Val Val Pro Ala Asn Thr Thr Ser Val 
865                 870                 875                 880 


Ile Leu Ser Gly Leu Arg Pro Tyr Ser Ser Tyr His Leu Glu Val Gln 
                885                 890                 895     


Ala Phe Asn Gly Arg Gly Ser Gly Pro Ala Ser Glu Phe Thr Phe Ser 
            900                 905                 910         


Thr Pro Glu Gly Val Pro Gly His Pro Glu Ala Leu His Leu Glu Cys 
        915                 920                 925             


Gln Ser Asn Thr Ser Leu Leu Leu Arg Trp Gln Pro Pro Leu Ser His 
    930                 935                 940                 


Asn Gly Val Leu Thr Gly Tyr Val Leu Ser Tyr His Pro Leu Asp Glu 
945                 950                 955                 960 


Gly Gly Lys Gly Gln Leu Ser Phe Asn Leu Arg Asp Pro Glu Leu Arg 
                965                 970                 975     


Thr His Asn Leu Thr Asp Leu Ser Pro His Leu Arg Tyr Arg Phe Gln 
            980                 985                 990         


Leu Gln Ala Thr Thr Lys Glu Gly  Pro Gly Glu Ala Ile  Val Arg Glu 
        995                 1000                 1005             


Gly Gly  Thr Met Ala Leu Ser  Gly Ile Ser Asp Phe  Gly Asn Ile 
    1010                 1015                 1020             


Ser Ala  Thr Ala Gly Glu Asn  Tyr Ser Val Val Ser  Trp Val Pro 
    1025                 1030                 1035             


Lys Glu  Gly Gln Cys Asn Phe  Arg Phe His Ile Leu  Phe Lys Ala 
    1040                 1045                 1050             


Leu Gly  Glu Glu Lys Gly Gly  Ala Ser Leu Ser Pro  Gln Tyr Val 
    1055                 1060                 1065             


Ser Tyr  Asn Gln Ser Ser Tyr  Thr Gln Trp Asp Leu  Gln Pro Asp 
    1070                 1075                 1080             


Thr Asp  Tyr Glu Ile His Leu  Phe Lys Glu Arg Met  Phe Arg His 
    1085                 1090                 1095             


Gln Met  Ala Val Lys Thr Asn  Gly Thr Gly Arg Val  Arg Leu Pro 
    1100                 1105                 1110             


Pro Ala  Gly Phe Ala Thr Glu  Gly Trp Phe Ile Gly  Phe Val Ser 
    1115                 1120                 1125             


Ala Ile  Ile Leu Leu Leu Leu  Val Leu Leu Ile Leu  Cys Phe Ile 
    1130                 1135                 1140             


Lys Arg  Ser Lys Gly Gly Lys  Tyr Ser Val Lys Asp  Lys Glu Asp 
    1145                 1150                 1155             


Thr Gln  Val Asp Ser Glu Ala  Arg Pro Met Lys Asp  Glu Thr Phe 
    1160                 1165                 1170             


Gly Glu  Tyr Arg Ser Leu Glu  Ser Asp Asn Glu Glu  Lys Ala Phe 
    1175                 1180                 1185             


Gly Ser  Ser Gln Pro Ser Leu  Asn Gly Asp Ile Lys  Pro Leu Gly 
    1190                 1195                 1200             


Ser Asp  Asp Ser Leu Ala Asp  Tyr Gly Gly Ser Val  Asp Val Gln 
    1205                 1210                 1215             


Phe Asn  Glu Asp Gly Ser Phe  Ile Gly Gln Tyr Ser  Gly Lys Lys 
    1220                 1225                 1230             


Glu Lys  Glu Ala Ala Gly Gly  Asn Asp Ser Ser Gly  Ala Thr Ser 
    1235                 1240                 1245             


Pro Ile  Asn Pro Ala Val Ala  Leu Glu 
    1250                 1255         


<210>  103
<211>  1311
<212>  PRT
<213>  Homo sapiens

<400>  103

Met Ser Arg Arg Lys Gln Ala Lys Pro Arg Ser Leu Lys Asp Pro Asn 
1               5                   10                  15      


Cys Lys Leu Glu Asp Lys Thr Glu Asp Gly Glu Ala Leu Asp Cys Lys 
            20                  25                  30          


Lys Arg Pro Glu Asp Gly Glu Glu Leu Glu Asp Glu Ala Val His Ser 
        35                  40                  45              


Cys Asp Ser Cys Leu Gln Val Phe Glu Ser Leu Ser Asp Ile Thr Glu 
    50                  55                  60                  


His Lys Ile Asn Gln Cys Gln Leu Thr Asp Gly Val Asp Val Glu Asp 
65                  70                  75                  80  


Asp Pro Thr Cys Ser Trp Pro Ala Ser Ser Pro Ser Ser Lys Asp Gln 
                85                  90                  95      


Thr Ser Pro Ser His Gly Glu Gly Cys Asp Phe Gly Glu Glu Glu Gly 
            100                 105                 110         


Gly Pro Gly Leu Pro Tyr Pro Cys Gln Phe Cys Asp Lys Ser Phe Ser 
        115                 120                 125             


Arg Leu Ser Tyr Leu Lys His His Glu Gln Ser His Ser Asp Lys Leu 
    130                 135                 140                 


Pro Phe Lys Cys Thr Tyr Cys Ser Arg Leu Phe Lys His Lys Arg Ser 
145                 150                 155                 160 


Arg Asp Arg His Ile Lys Leu His Thr Gly Asp Lys Lys Tyr His Cys 
                165                 170                 175     


Ser Glu Cys Asp Ala Ala Phe Ser Arg Ser Asp His Leu Lys Ile His 
            180                 185                 190         


Leu Lys Thr His Thr Ser Asn Lys Pro Tyr Lys Cys Ala Ile Cys Arg 
        195                 200                 205             


Arg Gly Phe Leu Ser Ser Ser Ser Leu His Gly His Met Gln Val His 
    210                 215                 220                 


Glu Arg Asn Lys Asp Gly Ser Gln Ser Gly Ser Arg Met Glu Asp Trp 
225                 230                 235                 240 


Lys Met Lys Asp Thr Gln Lys Cys Ser Gln Cys Glu Glu Gly Phe Asp 
                245                 250                 255     


Phe Pro Glu Asp Leu Gln Lys His Ile Ala Glu Cys His Pro Glu Cys 
            260                 265                 270         


Ser Pro Asn Glu Asp Arg Ala Ala Leu Gln Cys Val Tyr Cys His Glu 
        275                 280                 285             


Leu Phe Val Glu Glu Thr Ser Leu Met Asn His Met Glu Gln Val His 
    290                 295                 300                 


Ser Gly Glu Lys Lys Asn Ser Cys Ser Ile Cys Ser Glu Ser Phe His 
305                 310                 315                 320 


Thr Val Glu Glu Leu Tyr Ser His Met Asp Ser His Gln Gln Pro Glu 
                325                 330                 335     


Ser Cys Asn His Ser Asn Ser Pro Ser Leu Val Thr Val Gly Tyr Thr 
            340                 345                 350         


Ser Val Ser Ser Thr Thr Pro Asp Ser Asn Leu Ser Val Asp Ser Ser 
        355                 360                 365             


Thr Met Val Glu Ala Ala Pro Pro Ile Pro Lys Ser Arg Gly Arg Lys 
    370                 375                 380                 


Arg Ala Ala Gln Gln Thr Pro Asp Met Thr Gly Pro Ser Ser Lys Gln 
385                 390                 395                 400 


Ala Lys Val Thr Tyr Ser Cys Ile Tyr Cys Asn Lys Gln Leu Phe Ser 
                405                 410                 415     


Ser Leu Ala Val Leu Gln Ile His Leu Lys Thr Met His Leu Asp Lys 
            420                 425                 430         


Pro Glu Gln Ala His Ile Cys Gln Tyr Cys Leu Glu Val Leu Pro Ser 
        435                 440                 445             


Leu Tyr Asn Leu Asn Glu His Leu Lys Gln Val His Glu Ala Gln Asp 
    450                 455                 460                 


Pro Gly Leu Ile Val Ser Ala Met Pro Ala Ile Val Tyr Gln Cys Asn 
465                 470                 475                 480 


Phe Cys Ser Glu Val Val Asn Asp Leu Asn Thr Leu Gln Glu His Ile 
                485                 490                 495     


Arg Cys Ser His Gly Phe Ala Asn Pro Ala Ala Lys Asp Ser Asn Ala 
            500                 505                 510         


Phe Phe Cys Pro His Cys Tyr Met Gly Phe Leu Thr Asp Ser Ser Leu 
        515                 520                 525             


Glu Glu His Ile Arg Gln Val His Cys Asp Leu Ser Gly Ser Arg Phe 
    530                 535                 540                 


Gly Ser Pro Val Leu Gly Thr Pro Lys Glu Pro Val Val Glu Val Tyr 
545                 550                 555                 560 


Ser Cys Ser Tyr Cys Thr Asn Ser Pro Ile Phe Asn Ser Val Leu Lys 
                565                 570                 575     


Leu Asn Lys His Ile Lys Glu Asn His Lys Asn Ile Pro Leu Ala Leu 
            580                 585                 590         


Asn Tyr Ile His Asn Gly Lys Lys Ser Arg Ala Leu Ser Pro Leu Ser 
        595                 600                 605             


Pro Val Ala Ile Glu Gln Thr Ser Leu Lys Met Met Gln Ala Val Gly 
    610                 615                 620                 


Gly Ala Pro Ala Arg Pro Thr Gly Glu Tyr Ile Cys Asn Gln Cys Gly 
625                 630                 635                 640 


Ala Lys Tyr Thr Ser Leu Asp Ser Phe Gln Thr His Leu Lys Thr His 
                645                 650                 655     


Leu Asp Thr Val Leu Pro Lys Leu Thr Cys Pro Gln Cys Asn Lys Glu 
            660                 665                 670         


Phe Pro Asn Gln Glu Ser Leu Leu Lys His Val Thr Ile His Phe Met 
        675                 680                 685             


Ile Thr Ser Thr Tyr Tyr Ile Cys Glu Ser Cys Asp Lys Gln Phe Thr 
    690                 695                 700                 


Ser Val Asp Asp Leu Gln Lys His Leu Leu Asp Met His Thr Phe Val 
705                 710                 715                 720 


Phe Phe Arg Cys Thr Leu Cys Gln Glu Val Phe Asp Ser Lys Val Ser 
                725                 730                 735     


Ile Gln Leu His Leu Ala Val Lys His Ser Asn Glu Lys Lys Val Tyr 
            740                 745                 750         


Arg Cys Thr Ser Cys Asn Trp Asp Phe Arg Asn Glu Thr Asp Leu Gln 
        755                 760                 765             


Leu His Val Lys His Asn His Leu Glu Asn Gln Gly Lys Val His Lys 
    770                 775                 780                 


Cys Ile Phe Cys Gly Glu Ser Phe Gly Thr Glu Val Glu Leu Gln Cys 
785                 790                 795                 800 


His Ile Thr Thr His Ser Lys Lys Tyr Asn Cys Lys Phe Cys Ser Lys 
                805                 810                 815     


Ala Phe His Ala Ile Ile Leu Leu Glu Lys His Leu Arg Glu Lys His 
            820                 825                 830         


Cys Val Phe Glu Thr Lys Thr Pro Asn Cys Gly Thr Asn Gly Ala Ser 
        835                 840                 845             


Glu Gln Val Gln Lys Glu Glu Val Glu Leu Gln Thr Leu Leu Thr Asn 
    850                 855                 860                 


Ser Gln Glu Ser His Asn Ser His Asp Gly Ser Glu Glu Asp Val Asp 
865                 870                 875                 880 


Thr Ser Glu Pro Met Tyr Gly Cys Asp Ile Cys Gly Ala Ala Tyr Thr 
                885                 890                 895     


Met Glu Thr Leu Leu Gln Asn His Gln Leu Arg Asp His Asn Ile Arg 
            900                 905                 910         


Pro Gly Glu Ser Ala Ile Val Lys Lys Lys Ala Glu Leu Ile Lys Gly 
        915                 920                 925             


Asn Tyr Lys Cys Asn Val Cys Ser Arg Thr Phe Phe Ser Glu Asn Gly 
    930                 935                 940                 


Leu Arg Glu His Met Gln Thr His Leu Gly Pro Val Lys His Tyr Met 
945                 950                 955                 960 


Cys Pro Ile Cys Gly Glu Arg Phe Pro Ser Leu Leu Thr Leu Thr Glu 
                965                 970                 975     


His Lys Val Thr His Ser Lys Ser Leu Asp Thr Gly Asn Cys Arg Ile 
            980                 985                 990         


Cys Lys Met Pro Leu Gln Ser Glu  Glu Glu Phe Leu Glu  His Cys Gln 
        995                 1000                 1005             


Met His  Pro Asp Leu Arg Asn  Ser Leu Thr Gly Phe  Arg Cys Val 
    1010                 1015                 1020             


Val Cys  Met Gln Thr Val Thr  Ser Thr Leu Glu Leu  Lys Ile His 
    1025                 1030                 1035             


Gly Thr  Phe His Met Gln Lys  Thr Gly Asn Gly Ser  Ala Val Gln 
    1040                 1045                 1050             


Thr Thr  Gly Arg Gly Gln His  Val Gln Lys Leu Tyr  Lys Cys Ala 
    1055                 1060                 1065             


Ser Cys  Leu Lys Glu Phe Arg  Ser Lys Gln Asp Leu  Val Lys Leu 
    1070                 1075                 1080             


Asp Ile  Asn Gly Leu Pro Tyr  Gly Leu Cys Ala Gly  Cys Val Asn 
    1085                 1090                 1095             


Leu Ser  Lys Ser Ala Ser Pro  Gly Ile Asn Val Pro  Pro Gly Thr 
    1100                 1105                 1110             


Asn Arg  Pro Gly Leu Gly Gln  Asn Glu Asn Leu Ser  Ala Ile Glu 
    1115                 1120                 1125             


Gly Lys  Gly Lys Val Gly Gly  Leu Lys Thr Arg Cys  Ser Ser Cys 
    1130                 1135                 1140             


Asn Val  Lys Phe Glu Ser Glu  Ser Glu Leu Gln Asn  His Ile Gln 
    1145                 1150                 1155             


Thr Ile  His Arg Glu Leu Val  Pro Asp Ser Asn Ser  Thr Gln Leu 
    1160                 1165                 1170             


Lys Thr  Pro Gln Val Ser Pro  Met Pro Arg Ile Ser  Pro Ser Gln 
    1175                 1180                 1185             


Ser Asp  Glu Lys Lys Thr Tyr  Gln Cys Ile Lys Cys  Gln Met Val 
    1190                 1195                 1200             


Phe Tyr  Asn Glu Trp Asp Ile  Gln Val His Val Ala  Asn His Met 
    1205                 1210                 1215             


Ile Asp  Glu Gly Leu Asn His  Glu Cys Lys Leu Cys  Ser Gln Thr 
    1220                 1225                 1230             


Phe Asp  Ser Pro Ala Lys Leu  Gln Cys His Leu Ile  Glu His Ser 
    1235                 1240                 1245             


Phe Glu  Gly Met Gly Gly Thr  Phe Lys Cys Pro Val  Cys Phe Thr 
    1250                 1255                 1260             


Val Phe  Val Gln Ala Asn Lys  Leu Gln Gln His Ile  Phe Ser Ala 
    1265                 1270                 1275             


His Gly  Gln Glu Asp Lys Ile  Tyr Asp Cys Thr Gln  Cys Pro Gln 
    1280                 1285                 1290             


Lys Phe  Phe Phe Gln Thr Glu  Leu Gln Asn His Thr  Met Thr Gln 
    1295                 1300                 1305             


His Ser  Ser 
    1310     


<210>  104
<211>  239
<212>  PRT
<213>  Homo sapiens

<400>  104

Met Ala Pro Ser Val Pro Ala Ala Glu Pro Glu Tyr Pro Lys Gly Ile 
1               5                   10                  15      


Arg Ala Val Leu Leu Gly Pro Pro Gly Ala Gly Lys Gly Thr Gln Ala 
            20                  25                  30          


Pro Arg Leu Ala Glu Asn Phe Cys Val Cys His Leu Ala Thr Gly Asp 
        35                  40                  45              


Met Leu Arg Ala Met Val Ala Ser Gly Ser Glu Leu Gly Lys Lys Leu 
    50                  55                  60                  


Lys Ala Thr Met Asp Ala Gly Lys Leu Val Ser Asp Glu Met Val Val 
65                  70                  75                  80  


Glu Leu Ile Glu Lys Asn Leu Glu Thr Pro Leu Cys Lys Asn Gly Phe 
                85                  90                  95      


Leu Leu Asp Gly Phe Pro Arg Thr Val Arg Gln Ala Glu Met Leu Asp 
            100                 105                 110         


Asp Leu Met Glu Lys Arg Lys Glu Lys Leu Asp Ser Val Ile Glu Phe 
        115                 120                 125             


Ser Ile Pro Asp Ser Leu Leu Ile Arg Arg Ile Thr Gly Arg Leu Ile 
    130                 135                 140                 


His Pro Lys Ser Gly Arg Ser Tyr His Glu Glu Phe Asn Pro Pro Lys 
145                 150                 155                 160 


Glu Pro Met Lys Asp Asp Ile Thr Gly Glu Pro Leu Ile Arg Arg Ser 
                165                 170                 175     


Asp Asp Asn Glu Lys Ala Leu Lys Ile Arg Leu Gln Ala Tyr His Thr 
            180                 185                 190         


Gln Thr Thr Pro Leu Ile Glu Tyr Tyr Arg Lys Arg Gly Ile His Ser 
        195                 200                 205             


Ala Ile Asp Ala Ser Gln Thr Pro Asp Val Val Phe Ala Ser Ile Leu 
    210                 215                 220                 


Ala Ala Phe Ser Lys Ala Thr Cys Lys Asp Leu Val Met Phe Ile 
225                 230                 235                 


<210>  105
<211>  1140
<212>  PRT
<213>  Homo sapiens

<400>  105

Met Ser Tyr Asn Tyr Val Val Thr Ala Gln Lys Pro Thr Ala Val Asn 
1               5                   10                  15      


Gly Cys Val Thr Gly His Phe Thr Ser Ala Glu Asp Leu Asn Leu Leu 
            20                  25                  30          


Ile Ala Lys Asn Thr Arg Leu Glu Ile Tyr Val Val Thr Ala Glu Gly 
        35                  40                  45              


Leu Arg Pro Val Lys Glu Val Gly Met Tyr Gly Lys Ile Ala Val Met 
    50                  55                  60                  


Glu Leu Phe Arg Pro Lys Gly Glu Ser Lys Asp Leu Leu Phe Ile Leu 
65                  70                  75                  80  


Thr Ala Lys Tyr Asn Ala Cys Ile Leu Glu Tyr Lys Gln Ser Gly Glu 
                85                  90                  95      


Ser Ile Asp Ile Ile Thr Arg Ala His Gly Asn Val Gln Asp Arg Ile 
            100                 105                 110         


Gly Arg Pro Ser Glu Thr Gly Ile Ile Gly Ile Ile Asp Pro Glu Cys 
        115                 120                 125             


Arg Met Ile Gly Leu Arg Leu Tyr Asp Gly Leu Phe Lys Val Ile Pro 
    130                 135                 140                 


Leu Asp Arg Asp Asn Lys Glu Leu Lys Ala Phe Asn Ile Arg Leu Glu 
145                 150                 155                 160 


Glu Leu His Val Ile Asp Val Lys Phe Leu Tyr Gly Cys Gln Ala Pro 
                165                 170                 175     


Thr Ile Cys Phe Val Tyr Gln Asp Pro Gln Gly Arg His Val Lys Thr 
            180                 185                 190         


Tyr Glu Val Ser Leu Arg Glu Lys Glu Phe Asn Lys Gly Pro Trp Lys 
        195                 200                 205             


Gln Glu Asn Val Glu Ala Glu Ala Ser Met Val Ile Ala Val Pro Glu 
    210                 215                 220                 


Pro Phe Gly Gly Ala Ile Ile Ile Gly Gln Glu Ser Ile Thr Tyr His 
225                 230                 235                 240 


Asn Gly Asp Lys Tyr Leu Ala Ile Ala Pro Pro Ile Ile Lys Gln Ser 
                245                 250                 255     


Thr Ile Val Cys His Asn Arg Val Asp Pro Asn Gly Ser Arg Tyr Leu 
            260                 265                 270         


Leu Gly Asp Met Glu Gly Arg Leu Phe Met Leu Leu Leu Glu Lys Glu 
        275                 280                 285             


Glu Gln Met Asp Gly Thr Val Thr Leu Lys Asp Leu Arg Val Glu Leu 
    290                 295                 300                 


Leu Gly Glu Thr Ser Ile Ala Glu Cys Leu Thr Tyr Leu Asp Asn Gly 
305                 310                 315                 320 


Val Val Phe Val Gly Ser Arg Leu Gly Asp Ser Gln Leu Val Lys Leu 
                325                 330                 335     


Asn Val Asp Ser Asn Glu Gln Gly Ser Tyr Val Val Ala Met Glu Thr 
            340                 345                 350         


Phe Thr Asn Leu Gly Pro Ile Val Asp Met Cys Val Val Asp Leu Glu 
        355                 360                 365             


Arg Gln Gly Gln Gly Gln Leu Val Thr Cys Ser Gly Ala Phe Lys Glu 
    370                 375                 380                 


Gly Ser Leu Arg Ile Ile Arg Asn Gly Ile Gly Ile His Glu His Ala 
385                 390                 395                 400 


Ser Ile Asp Leu Pro Gly Ile Lys Gly Leu Trp Pro Leu Arg Ser Asp 
                405                 410                 415     


Pro Asn Arg Glu Thr Asp Asp Thr Leu Val Leu Ser Phe Val Gly Gln 
            420                 425                 430         


Thr Arg Val Leu Met Leu Asn Gly Glu Glu Val Glu Glu Thr Glu Leu 
        435                 440                 445             


Met Gly Phe Val Asp Asp Gln Gln Thr Phe Phe Cys Gly Asn Val Ala 
    450                 455                 460                 


His Gln Gln Leu Ile Gln Ile Thr Ser Ala Ser Val Arg Leu Val Ser 
465                 470                 475                 480 


Gln Glu Pro Lys Ala Leu Val Ser Glu Trp Lys Glu Pro Gln Ala Lys 
                485                 490                 495     


Asn Ile Ser Val Ala Ser Cys Asn Ser Ser Gln Val Val Val Ala Val 
            500                 505                 510         


Gly Arg Ala Leu Tyr Tyr Leu Gln Ile His Pro Gln Glu Leu Arg Gln 
        515                 520                 525             


Ile Ser His Thr Glu Met Glu His Glu Val Ala Cys Leu Asp Ile Thr 
    530                 535                 540                 


Pro Leu Gly Asp Ser Asn Gly Leu Ser Pro Leu Cys Ala Ile Gly Leu 
545                 550                 555                 560 


Trp Thr Asp Ile Ser Ala Arg Ile Leu Lys Leu Pro Ser Phe Glu Leu 
                565                 570                 575     


Leu His Lys Glu Met Leu Gly Gly Glu Ile Ile Pro Arg Ser Ile Leu 
            580                 585                 590         


Met Thr Thr Phe Glu Ser Ser His Tyr Leu Leu Cys Ala Leu Gly Asp 
        595                 600                 605             


Gly Ala Leu Phe Tyr Phe Gly Leu Asn Ile Glu Thr Gly Leu Leu Ser 
    610                 615                 620                 


Asp Arg Lys Lys Val Thr Leu Gly Thr Gln Pro Thr Val Leu Arg Thr 
625                 630                 635                 640 


Phe Arg Ser Leu Ser Thr Thr Asn Val Phe Ala Cys Ser Asp Arg Pro 
                645                 650                 655     


Thr Val Ile Tyr Ser Ser Asn His Lys Leu Val Phe Ser Asn Val Asn 
            660                 665                 670         


Leu Lys Glu Val Asn Tyr Met Cys Pro Leu Asn Ser Asp Gly Tyr Pro 
        675                 680                 685             


Asp Ser Leu Ala Leu Ala Asn Asn Ser Thr Leu Thr Ile Gly Thr Ile 
    690                 695                 700                 


Asp Glu Ile Gln Lys Leu His Ile Arg Thr Val Pro Leu Tyr Glu Ser 
705                 710                 715                 720 


Pro Arg Lys Ile Cys Tyr Gln Glu Val Ser Gln Cys Phe Gly Val Leu 
                725                 730                 735     


Ser Ser Arg Ile Glu Val Gln Asp Thr Ser Gly Gly Thr Thr Ala Leu 
            740                 745                 750         


Arg Pro Ser Ala Ser Thr Gln Ala Leu Ser Ser Ser Val Ser Ser Ser 
        755                 760                 765             


Lys Leu Phe Ser Ser Ser Thr Ala Pro His Glu Thr Ser Phe Gly Glu 
    770                 775                 780                 


Glu Val Glu Val His Asn Leu Leu Ile Ile Asp Gln His Thr Phe Glu 
785                 790                 795                 800 


Val Leu His Ala His Gln Phe Leu Gln Asn Glu Tyr Ala Leu Ser Leu 
                805                 810                 815     


Val Ser Cys Lys Leu Gly Lys Asp Pro Asn Thr Tyr Phe Ile Val Gly 
            820                 825                 830         


Thr Ala Met Val Tyr Pro Glu Glu Ala Glu Pro Lys Gln Gly Arg Ile 
        835                 840                 845             


Val Val Phe Gln Tyr Ser Asp Gly Lys Leu Gln Thr Val Ala Glu Lys 
    850                 855                 860                 


Glu Val Lys Gly Ala Val Tyr Ser Met Val Glu Phe Asn Gly Lys Leu 
865                 870                 875                 880 


Leu Ala Ser Ile Asn Ser Thr Val Arg Leu Tyr Glu Trp Thr Thr Glu 
                885                 890                 895     


Lys Glu Leu Arg Thr Glu Cys Asn His Tyr Asn Asn Ile Met Ala Leu 
            900                 905                 910         


Tyr Leu Lys Thr Lys Gly Asp Phe Ile Leu Val Gly Asp Leu Met Arg 
        915                 920                 925             


Ser Val Leu Leu Leu Ala Tyr Lys Pro Met Glu Gly Asn Phe Glu Glu 
    930                 935                 940                 


Ile Ala Arg Asp Phe Asn Pro Asn Trp Met Ser Ala Val Glu Ile Leu 
945                 950                 955                 960 


Asp Asp Asp Asn Phe Leu Gly Ala Glu Asn Ala Phe Asn Leu Phe Val 
                965                 970                 975     


Cys Gln Lys Asp Ser Ala Ala Thr Thr Asp Glu Glu Arg Gln His Leu 
            980                 985                 990         


Gln Glu Val Gly Leu Phe His Leu  Gly Glu Phe Val Asn  Val Phe Cys 
        995                 1000                 1005             


His Gly  Ser Leu Val Met Gln  Asn Leu Gly Glu Thr  Ser Thr Pro 
    1010                 1015                 1020             


Thr Gln  Gly Ser Val Leu Phe  Gly Thr Val Asn Gly  Met Ile Gly 
    1025                 1030                 1035             


Leu Val  Thr Ser Leu Ser Glu  Ser Trp Tyr Asn Leu  Leu Leu Asp 
    1040                 1045                 1050             


Met Gln  Asn Arg Leu Asn Lys  Val Ile Lys Ser Val  Gly Lys Ile 
    1055                 1060                 1065             


Glu His  Ser Phe Trp Arg Ser  Phe His Thr Glu Arg  Lys Thr Glu 
    1070                 1075                 1080             


Pro Ala  Thr Gly Phe Ile Asp  Gly Asp Leu Ile Glu  Ser Phe Leu 
    1085                 1090                 1095             


Asp Ile  Ser Arg Pro Lys Met  Gln Glu Val Val Ala  Asn Leu Gln 
    1100                 1105                 1110             


Tyr Asp  Asp Gly Ser Gly Met  Lys Arg Glu Ala Thr  Ala Asp Asp 
    1115                 1120                 1125             


Leu Ile  Lys Val Val Glu Glu  Leu Thr Arg Ile His  
    1130                 1135                 1140 


<210>  106
<211>  1133
<212>  PRT
<213>  Homo sapiens

<400>  106

Met Leu Ala Tyr Cys Val Gln Asp Ala Thr Val Val Asp Val Glu Lys 
1               5                   10                  15      


Arg Arg Asn Pro Ser Lys His Tyr Val Tyr Ile Ile Asn Val Thr Trp 
            20                  25                  30          


Ser Asp Ser Thr Ser Gln Thr Ile Tyr Arg Arg Tyr Ser Lys Phe Phe 
        35                  40                  45              


Asp Leu Gln Met Gln Leu Leu Asp Lys Phe Pro Ile Glu Gly Gly Gln 
    50                  55                  60                  


Lys Asp Pro Lys Gln Arg Ile Ile Pro Phe Leu Pro Gly Lys Ile Leu 
65                  70                  75                  80  


Phe Arg Arg Ser His Ile Arg Asp Val Ala Val Lys Arg Leu Lys Pro 
                85                  90                  95      


Ile Asp Glu Tyr Cys Arg Ala Leu Val Arg Leu Pro Pro His Ile Ser 
            100                 105                 110         


Gln Cys Asp Glu Val Phe Arg Phe Phe Glu Ala Arg Pro Glu Asp Val 
        115                 120                 125             


Asn Pro Pro Lys Glu Asp Tyr Gly Ser Ser Lys Arg Lys Ser Val Trp 
    130                 135                 140                 


Leu Ser Ser Trp Ala Glu Ser Pro Lys Lys Asp Val Thr Gly Ala Asp 
145                 150                 155                 160 


Ala Thr Ala Glu Pro Met Ile Leu Glu Gln Tyr Val Val Val Ser Asn 
                165                 170                 175     


Tyr Lys Lys Gln Glu Asn Ser Glu Leu Ser Leu Gln Ala Gly Glu Val 
            180                 185                 190         


Val Asp Val Ile Glu Lys Asn Glu Ser Gly Trp Trp Phe Val Ser Thr 
        195                 200                 205             


Ser Glu Glu Gln Gly Trp Val Pro Ala Thr Tyr Leu Glu Ala Gln Asn 
    210                 215                 220                 


Gly Thr Arg Asp Asp Ser Asp Ile Asn Thr Ser Lys Thr Gly Glu Val 
225                 230                 235                 240 


Ser Lys Arg Arg Lys Ala His Leu Arg Arg Leu Asp Arg Arg Trp Thr 
                245                 250                 255     


Leu Gly Gly Met Val Asn Arg Gln His Ser Arg Glu Glu Lys Tyr Val 
            260                 265                 270         


Thr Val Gln Pro Tyr Thr Ser Gln Ser Lys Asp Glu Ile Gly Phe Glu 
        275                 280                 285             


Lys Gly Val Thr Val Glu Val Ile Arg Lys Asn Leu Glu Gly Trp Trp 
    290                 295                 300                 


Tyr Ile Arg Tyr Leu Gly Lys Glu Gly Trp Ala Pro Ala Ser Tyr Leu 
305                 310                 315                 320 


Lys Lys Ala Lys Asp Asp Leu Pro Thr Arg Lys Lys Asn Leu Ala Gly 
                325                 330                 335     


Pro Val Glu Ile Ile Gly Asn Ile Met Glu Ile Ser Asn Leu Leu Asn 
            340                 345                 350         


Lys Lys Ala Ser Gly Asp Lys Glu Thr Pro Pro Ala Glu Gly Glu Gly 
        355                 360                 365             


His Glu Ala Pro Ile Ala Lys Lys Glu Ile Ser Leu Pro Ile Leu Cys 
    370                 375                 380                 


Asn Ala Ser Asn Gly Ser Ala Val Gly Val Pro Asp Arg Thr Val Ser 
385                 390                 395                 400 


Arg Leu Ala Gln Gly Ser Pro Ala Val Ala Arg Ile Ala Pro Gln Arg 
                405                 410                 415     


Ala Gln Ile Ser Ser Pro Asn Leu Arg Thr Arg Pro Pro Pro Arg Arg 
            420                 425                 430         


Glu Ser Ser Leu Gly Phe Gln Leu Pro Lys Pro Pro Glu Pro Pro Ser 
        435                 440                 445             


Val Glu Val Glu Tyr Tyr Thr Ile Ala Glu Phe Gln Ser Cys Ile Ser 
    450                 455                 460                 


Asp Gly Ile Ser Phe Arg Gly Gly Gln Lys Ala Glu Val Ile Asp Lys 
465                 470                 475                 480 


Asn Ser Gly Gly Trp Trp Tyr Val Gln Ile Gly Glu Lys Glu Gly Trp 
                485                 490                 495     


Ala Pro Ala Ser Tyr Ile Asp Lys Arg Lys Lys Pro Asn Leu Ser Arg 
            500                 505                 510         


Arg Thr Ser Thr Leu Thr Arg Pro Lys Val Pro Pro Pro Ala Pro Pro 
        515                 520                 525             


Ser Lys Pro Lys Glu Ala Glu Glu Gly Pro Thr Gly Ala Ser Glu Ser 
    530                 535                 540                 


Gln Asp Ser Pro Arg Lys Leu Lys Tyr Glu Glu Pro Glu Tyr Asp Ile 
545                 550                 555                 560 


Pro Ala Phe Gly Phe Asp Ser Glu Pro Glu Leu Ser Glu Glu Pro Val 
                565                 570                 575     


Glu Asp Arg Ala Ser Gly Glu Arg Arg Pro Ala Gln Pro His Arg Pro 
            580                 585                 590         


Ser Pro Ala Ser Ser Leu Gln Arg Ala Arg Phe Lys Val Gly Glu Ser 
        595                 600                 605             


Ser Glu Asp Val Ala Leu Glu Glu Glu Thr Ile Tyr Glu Asn Glu Gly 
    610                 615                 620                 


Phe Arg Pro Tyr Ala Glu Asp Thr Leu Ser Ala Arg Gly Ser Ser Gly 
625                 630                 635                 640 


Asp Ser Asp Ser Pro Gly Ser Ser Ser Leu Ser Leu Thr Arg Lys Asn 
                645                 650                 655     


Ser Pro Lys Ser Gly Ser Pro Lys Ser Ser Ser Leu Leu Lys Leu Lys 
            660                 665                 670         


Ala Glu Lys Asn Ala Gln Ala Glu Met Gly Lys Asn His Ser Ser Ala 
        675                 680                 685             


Ser Phe Ser Ser Ser Ile Thr Ile Asn Thr Thr Cys Cys Ser Ser Ser 
    690                 695                 700                 


Ser Ser Ser Ser Ser Ser Leu Ser Lys Thr Ser Gly Asp Leu Lys Pro 
705                 710                 715                 720 


Arg Ser Ala Ser Asp Ala Gly Ile Arg Gly Thr Pro Lys Val Arg Ala 
                725                 730                 735     


Lys Lys Asp Ala Asp Ala Asn Ala Gly Leu Thr Ser Cys Pro Arg Ala 
            740                 745                 750         


Lys Pro Ser Val Arg Pro Lys Pro Phe Leu Asn Arg Ala Glu Ser Gln 
        755                 760                 765             


Ser Gln Glu Lys Met Asp Ile Ser Thr Leu Arg Arg Gln Leu Arg Pro 
    770                 775                 780                 


Thr Gly Gln Leu Arg Gly Gly Leu Lys Gly Ser Lys Ser Glu Asp Ser 
785                 790                 795                 800 


Glu Leu Pro Pro Gln Thr Ala Ser Glu Ala Pro Ser Glu Gly Ser Arg 
                805                 810                 815     


Arg Ser Ser Ser Asp Leu Ile Thr Leu Pro Ala Thr Thr Pro Pro Cys 
            820                 825                 830         


Pro Thr Lys Lys Glu Trp Glu Gly Pro Ala Thr Ser Tyr Met Thr Cys 
        835                 840                 845             


Ser Ala Tyr Gln Lys Val Gln Asp Ser Glu Ile Ser Phe Pro Ala Gly 
    850                 855                 860                 


Val Glu Val Gln Val Leu Glu Lys Gln Glu Ser Gly Trp Trp Tyr Val 
865                 870                 875                 880 


Arg Phe Gly Glu Leu Glu Gly Trp Ala Pro Ser His Tyr Leu Val Leu 
                885                 890                 895     


Asp Glu Asn Glu Gln Pro Asp Pro Ser Gly Lys Glu Leu Asp Thr Val 
            900                 905                 910         


Pro Ala Lys Gly Arg Gln Asn Glu Gly Lys Ser Asp Ser Leu Glu Lys 
        915                 920                 925             


Ile Glu Arg Arg Val Gln Ala Leu Asn Thr Val Asn Gln Ser Lys Lys 
    930                 935                 940                 


Ala Thr Pro Pro Ile Pro Ser Lys Pro Pro Gly Gly Phe Gly Lys Thr 
945                 950                 955                 960 


Ser Gly Thr Pro Ala Val Lys Met Arg Asn Gly Val Arg Gln Val Ala 
                965                 970                 975     


Val Arg Pro Gln Ser Val Phe Val Ser Pro Pro Pro Lys Asp Asn Asn 
            980                 985                 990         


Leu Ser Cys Ala Leu Arg Arg Asn  Glu Ser Leu Thr Ala  Thr Asp Gly 
        995                 1000                 1005             


Leu Arg  Gly Val Arg Arg Asn  Ser Ser Phe Ser Thr  Ala Arg Ser 
    1010                 1015                 1020             


Ala Ala  Ala Glu Ala Lys Gly  Arg Leu Ala Glu Arg  Ala Ala Ser 
    1025                 1030                 1035             


Gln Gly  Ser Asp Ser Pro Leu  Leu Pro Ala Gln Arg  Asn Ser Ile 
    1040                 1045                 1050             


Pro Val  Ser Pro Val Arg Pro  Lys Pro Ile Glu Lys  Ser Gln Phe 
    1055                 1060                 1065             


Ile His  Asn Asn Leu Lys Asp  Val Tyr Val Ser Ile  Ala Asp Tyr 
    1070                 1075                 1080             


Glu Gly  Asp Glu Glu Thr Ala  Gly Phe Gln Glu Gly  Val Ser Met 
    1085                 1090                 1095             


Glu Val  Leu Glu Arg Asn Pro  Asn Gly Trp Trp Tyr  Cys Gln Ile 
    1100                 1105                 1110             


Leu Asp  Gly Val Lys Pro Phe  Lys Gly Trp Val Pro  Ser Asn Tyr 
    1115                 1120                 1125             


Leu Glu  Lys Lys Asn 
    1130             


<210>  107
<211>  2624
<212>  PRT
<213>  Homo sapiens

<400>  107

Met Phe Arg Arg Ala Arg Leu Ser Val Lys Pro Asn Val Arg Pro Gly 
1               5                   10                  15      


Val Gly Ala Arg Gly Ser Thr Ala Ser Asn Pro Gln Arg Gly Arg Glu 
            20                  25                  30          


Ser Pro Arg Pro Pro Glu Pro Ala Thr Asp Ser Ala Ser Lys Pro Ala 
        35                  40                  45              


Glu Pro Thr Asp Val Pro Thr Val Asp Phe Gly Gly Ala Glu Pro Gln 
    50                  55                  60                  


Glu Lys Ala Pro Arg Ser Ser Thr Glu Lys Thr Gly Gly Asp Asn Asp 
65                  70                  75                  80  


Val Glu Glu Ser Ser Arg Ser Ser Ser Thr Val Ser Gln Arg Arg Lys 
                85                  90                  95      


Arg Ile Ser Ser Thr Ser Ser Leu Val Lys Ser Ser Val Ser Val Pro 
            100                 105                 110         


Ser Glu Ser His Pro Leu Ser Thr Ile Asn Gln Glu Ala Pro Gln Pro 
        115                 120                 125             


Thr Ala Thr Ser Thr Lys Glu Lys Gln Pro Cys Ser Asp Arg Tyr Arg 
    130                 135                 140                 


Ile Tyr Lys Ala Gln Lys Leu Arg Glu Met Leu Lys Glu Glu Leu Arg 
145                 150                 155                 160 


Lys Glu Lys Lys Gln Trp Lys Asn Lys Tyr Ala Ile Asn Glu Ser Gln 
                165                 170                 175     


Arg Pro Pro Asp Arg Ser Lys Met Thr Met Arg Asp Phe Ile Tyr Tyr 
            180                 185                 190         


Leu Pro Asp Asn Asn Pro Met Thr Ser Ser Leu Glu Gln Glu Lys Lys 
        195                 200                 205             


Thr Glu Lys Pro Ser Thr Pro Val Gln Thr Arg Glu Gln Glu Gly Lys 
    210                 215                 220                 


Ser Thr Pro Asn Ala Glu Asp Asn Glu Met Glu Glu Glu Thr Asp Asp 
225                 230                 235                 240 


Gly Pro Leu Leu Val Pro Arg Val Lys Val Ala Glu Asp Gly Ser Ile 
                245                 250                 255     


Ile Leu Asp Glu Glu Ser Leu Thr Val Glu Val Leu Arg Thr Lys Gly 
            260                 265                 270         


Pro Cys Val Val Glu Glu Asn Asp Pro Ile Phe Glu Arg Gly Ser Thr 
        275                 280                 285             


Thr Thr Tyr Ser Ser Phe Arg Lys Asn Tyr Tyr Ser Lys Pro Trp Ser 
    290                 295                 300                 


Asn Lys Glu Thr Asp Met Phe Phe Leu Ala Ile Ser Met Val Gly Thr 
305                 310                 315                 320 


Asp Phe Ser Met Ile Gly Gln Leu Phe Pro His Arg Ala Arg Ile Glu 
                325                 330                 335     


Ile Lys Asn Lys Phe Lys Arg Glu Glu Lys Thr Asn Gly Trp Arg Ile 
            340                 345                 350         


Asp Lys Ala Phe Gln Glu Lys Arg Pro Phe Asp Phe Asp Phe Phe Ala 
        355                 360                 365             


His Leu Leu Gln Lys Val Leu Ala Glu Glu Glu Lys Arg Lys Gln Lys 
    370                 375                 380                 


Ser Val Lys Asn His Ser Leu Lys Glu Lys Lys Ser Thr Lys Pro Arg 
385                 390                 395                 400 


Lys Asn Val Lys Val Lys Lys Val Ala Cys Glu Gly Val Asn Asn Asp 
                405                 410                 415     


Pro Asp Glu Ser Met Ser Ser Arg Ile Ser Asp Thr Glu Arg Ser Gln 
            420                 425                 430         


Lys Asp Ala Gln Thr Val Glu Glu Glu Ser Leu Thr Leu Ser Arg Glu 
        435                 440                 445             


Asp Ala Glu Gln Val Ala Leu Glu Val Asp Leu Asn Gln Lys Lys Arg 
    450                 455                 460                 


Arg Arg Lys Lys Gln Asp Gly Ala Asn Glu Leu Gly Val Asn Asn Leu 
465                 470                 475                 480 


Leu Glu Asn Ala Thr Val Gln Ala Gly Pro Ser Lys Gly Glu Lys His 
                485                 490                 495     


Lys Asn Lys Cys Gln Ala Ile Arg Pro Glu Leu Lys Glu Gly Glu Cys 
            500                 505                 510         


Ser Lys Glu Gln Met Leu Ser Cys Thr Gln Asn Ile Asp Gly Ile Val 
        515                 520                 525             


Gly Phe Ala Ser Thr Glu Lys Val Glu Lys Arg Thr Asp Pro Ile Leu 
    530                 535                 540                 


Ser Leu Ser Asn Gln Gln Asp Ala Thr Ser Val Ala Thr Glu Ser Ser 
545                 550                 555                 560 


Glu Ser Ser Thr Ser Asp Leu Pro Ser Phe Glu Val Gly Ile Arg Ala 
                565                 570                 575     


Leu Cys Glu Val Asn Asn Ala Glu Gly Ser Cys Ile Glu Glu Arg Asn 
            580                 585                 590         


Val Asp Leu Lys Asn Asn Ser Leu Glu Ile Asp Gln Thr Glu Asn Val 
        595                 600                 605             


Lys Pro Met Leu Arg Gly Arg Phe Gln Arg Pro Lys Pro Asn Leu Ser 
    610                 615                 620                 


Arg Ala Gly Lys Lys Ser Val Leu Ser Gln Gly Lys Thr Glu Ser Glu 
625                 630                 635                 640 


Ser Lys Asn Ser His Ser Lys Thr Ser Val Glu Lys Asn His Val Glu 
                645                 650                 655     


Lys Asp Lys Met Asn Thr Leu Asp Ile Leu Arg Met Glu Thr Thr Glu 
            660                 665                 670         


Arg Glu Asn Pro Glu Ala Glu Thr Val Ser Val Leu Gly Glu Lys Asn 
        675                 680                 685             


Cys Leu Gln Glu Gly Ser Gln Leu Lys Ala Leu Arg Pro Val Gln Val 
    690                 695                 700                 


Arg Gly Arg Leu Gln Lys Pro Lys Pro Asn Ala Gly Lys Ala Ala Glu 
705                 710                 715                 720 


Arg Lys Glu Ile Leu Ile Ser Gln Glu Glu Ile Gly Ala Asn Val Glu 
                725                 730                 735     


Lys Asn Glu Asn Glu Ser Cys Ala Asp Arg Asp Thr Pro Gln His Met 
            740                 745                 750         


Glu Asp Gln Ser Cys Lys Asp Phe Glu Glu Glu Asp Val Ile Leu Gln 
        755                 760                 765             


Pro Glu Lys Asn Asp Ser Phe Gln Asn Val Gln Pro Asp Glu Pro Lys 
    770                 775                 780                 


Val Leu Asn Glu Cys Leu Ser Val Gln Glu Asn Asn Lys Ala Asn Lys 
785                 790                 795                 800 


Leu Asn Gln Val Pro Ile Leu Arg Thr Arg Phe Gln Lys Pro Lys Pro 
                805                 810                 815     


Asn Ile Gly Arg Gly Thr Gly Arg Arg Glu Ile Ser Ser Lys Glu Glu 
            820                 825                 830         


Val Leu Glu Lys Ile Leu Val Ser Gly Glu Met Ala Ala Ala Leu Arg 
        835                 840                 845             


Glu Thr Val Arg Leu Asp Thr Ser Pro Lys Glu Met Val Pro Ala Glu 
    850                 855                 860                 


Ile Asn Thr Lys Glu Met Gln Ser Asp Leu Lys Glu Thr Gly Arg Arg 
865                 870                 875                 880 


Ala Ile Ser Pro Arg Glu Lys Ile Leu Asp Val Ile Asp Asp Thr Ile 
                885                 890                 895     


Glu Met Glu Thr Gly Leu Lys Ala Met Gly Arg Glu Ile Cys Leu Arg 
            900                 905                 910         


Glu Lys Thr Pro Glu Val Ile Asp Ala Thr Glu Glu Ile Asp Lys Asp 
        915                 920                 925             


Leu Glu Glu Ala Gly Arg Arg Glu Ile Ser Pro Gln Lys Asn Gly Pro 
    930                 935                 940                 


Glu Glu Val Lys Pro Leu Gly Glu Val Glu Thr Asp Leu Lys Ala Thr 
945                 950                 955                 960 


Gly Asn Glu Ser Ser Pro Arg Glu Lys Thr Pro Glu Val Thr Asp Ala 
                965                 970                 975     


Thr Glu Glu Ile Asp Lys Asn Leu Glu Glu Thr Gly Arg Arg Lys Ile 
            980                 985                 990         


Ser Pro Arg Glu Asn Gly Pro Glu  Glu Val Lys Pro Val  Asp Glu Met 
        995                 1000                 1005             


Glu Thr  Asp Leu Asn Ala Thr  Gly Arg Glu Ser Ser  Pro Arg Glu 
    1010                 1015                 1020             


Lys Thr  Pro Glu Val Ile Asp  Ala Thr Glu Glu Ile  Asp Leu Glu 
    1025                 1030                 1035             


Glu Thr  Glu Arg Glu Val Ser  Pro Gln Glu Asn Gly  Leu Glu Glu 
    1040                 1045                 1050             


Val Lys  Pro Leu Gly Glu Met  Glu Thr Asp Leu Lys  Ala Thr Gly 
    1055                 1060                 1065             


Arg Asp  Ser Phe Pro Arg Gly  Lys Thr Pro Glu Val  Ile Asp Ala 
    1070                 1075                 1080             


Ile Glu  Glu Ile Glu Ile Asp  Leu Glu Glu Thr Glu  Arg Glu Ile 
    1085                 1090                 1095             


Ser Pro  Gln Glu Asn Gly Leu  Glu Glu Val Lys Pro  Leu Gly Glu 
    1100                 1105                 1110             


Met Gln  Thr Asp Leu Lys Ala  Thr Gly Arg Glu Ile  Ser Pro Arg 
    1115                 1120                 1125             


Glu Lys  Thr Pro Glu Val Ile  Asp Ala Thr Glu Glu  Ile Asp Lys 
    1130                 1135                 1140             


Asp Leu  Glu Glu Thr Gly Arg  Arg Glu Ile Ser Pro  Glu Glu Asn 
    1145                 1150                 1155             


Gly Pro  Glu Glu Val Lys Pro  Val Asp Glu Met Glu  Thr Asp Leu 
    1160                 1165                 1170             


Lys Thr  Thr Gly Arg Glu Gly  Ser Ser Arg Glu Lys  Thr Arg Glu 
    1175                 1180                 1185             


Val Ile  Asp Ala Ala Glu Val  Ile Glu Thr Asp Leu  Glu Glu Thr 
    1190                 1195                 1200             


Glu Arg  Glu Ile Ser Pro Gln  Glu Asn Gly Pro Glu  Glu Val Lys 
    1205                 1210                 1215             


Pro Val  Gly Lys Met Glu Thr  Asp Leu Lys Glu Ile  Arg Glu Glu 
    1220                 1225                 1230             


Ile Ser  Gln Arg Glu Lys Val  Leu Ala Glu Phe Ser  Ala Ile Arg 
    1235                 1240                 1245             


Glu Lys  Glu Ile Asp Leu Lys  Glu Thr Gly Lys Arg  Asp Ile Pro 
    1250                 1255                 1260             


Met Met  Glu Lys Val Ser Gly  Lys Met Ala Val Val  Glu Glu Met 
    1265                 1270                 1275             


Glu Ala  Asp Leu Lys Glu Thr  Gly Lys Glu Asn Phe  Arg Glu Arg 
    1280                 1285                 1290             


Gly Ser  Glu Glu Ile Cys Val  Thr Glu Glu Lys Val  Ala Glu Leu 
    1295                 1300                 1305             


Lys Gln  Thr Gly Lys Thr Asp  Ile Ser Pro Arg Glu  Asn Glu Leu 
    1310                 1315                 1320             


Glu Glu  Thr Ser Thr Ser Arg  Gln Thr Asp Thr His  Leu Met Gln 
    1325                 1330                 1335             


Ser Gly  Ser Asn Asp Phe Ser  Ala Met Pro Ser Leu  Asp Ile Gln 
    1340                 1345                 1350             


Asn Ile  Ser Ser Glu Val Leu  Ser Met Met His Thr  Pro Val Glu 
    1355                 1360                 1365             


Glu Lys  Arg Asn Ser Glu Lys  Glu Val Ser Ser His  Phe Ser His 
    1370                 1375                 1380             


Phe Lys  Ile Ser Ser Gln Thr  His Glu Ser Asp Lys  Thr Glu Val 
    1385                 1390                 1395             


Gln Gly  Ile Gln Ser Pro Asp  Val Pro Glu Gln Phe  Ser Asp Ile 
    1400                 1405                 1410             


Asn Leu  Ser Lys Ser Leu Pro  Gln Glu Gln Lys Pro  Leu Glu Ile 
    1415                 1420                 1425             


Lys Pro  Ala Pro Phe Val Arg  Ser Arg Phe Lys Arg  Pro Lys Pro 
    1430                 1435                 1440             


Asn Leu  Ala Arg Ala Ala Leu  Lys Arg Glu Thr Thr  Glu Ser Glu 
    1445                 1450                 1455             


Lys Tyr  Ile Tyr Glu Lys Lys  Ser Glu Thr Lys Lys  Met Glu Thr 
    1460                 1465                 1470             


Ile Val  Met Gln Glu Asn Asn  Glu Gln Thr Asp Thr  Leu Pro Ser 
    1475                 1480                 1485             


Gln His  Asp Glu Ala Ser Leu  Met Ile Ser Arg Glu  Lys Asp Thr 
    1490                 1495                 1500             


Leu Gly  His Arg Asn Glu Glu  Ala Val Ile Leu Pro  Cys Thr Gln 
    1505                 1510                 1515             


Thr Glu  Arg Asn Leu Ser Pro  Ser Asn Ser Cys Glu  Pro Lys Glu 
    1520                 1525                 1530             


Glu Ser  Gln Ser Ala Pro Val  Gln Lys Asn Asp Ser  Val Val Ser 
    1535                 1540                 1545             


Val Gly  Thr Asn Asn Val Asn  Thr Phe Gln Gln Glu  Met Lys Glu 
    1550                 1555                 1560             


Ser Val  Ile Gln Thr Ala Arg  Gln Val Arg Gly Arg  Leu Gln Arg 
    1565                 1570                 1575             


Pro Arg  Pro Asn Ile Arg Lys  Thr Gly Gln Arg Gln  Ile Val Asp 
    1580                 1585                 1590             


Lys Gly  Glu Ala Lys Gly Ile  Ile Lys Glu Gly Arg  Thr Ile Leu 
    1595                 1600                 1605             


Pro Lys  Asp Glu Thr Glu Lys  Lys Val Leu Thr Val  Ser Asn Ser 
    1610                 1615                 1620             


Gln Ile  Glu Thr Glu Ile Glu  Val Pro Ser Ser Ala  Val Pro Glu 
    1625                 1630                 1635             


His Arg  Met Tyr Glu Asn Gln  Ser Gln Val Val Leu  Val Glu Asn 
    1640                 1645                 1650             


Leu His  Val Asn Lys Thr Asn  Glu Thr Ile Arg His  Glu Asn Lys 
    1655                 1660                 1665             


Pro Tyr  Val Pro Ser Ser Ala  Gln Met Thr Arg Arg  Lys Phe Gln 
    1670                 1675                 1680             


Lys Ala  Lys Pro Asn Leu Gly  Arg Ala His Ser Lys  Lys Glu Glu 
    1685                 1690                 1695             


Pro Val  Leu Glu Lys Val Thr  Thr Asp Gln Ser Lys  Glu Gly Lys 
    1700                 1705                 1710             


Pro Glu  Asp His Leu Leu Gln  Lys Gly Ala Ser Asn  Thr Gln Leu 
    1715                 1720                 1725             


Leu Leu  Lys Glu Lys Ala Glu  Leu Leu Thr Ser Leu  Glu Val Ser 
    1730                 1735                 1740             


Ala Arg  Lys Asp Cys Val Gly  Ser Lys Glu Ser Ala  Leu Ala Lys 
    1745                 1750                 1755             


Ile Asp  Ala Glu Leu Glu Glu  Val Gly Pro Ser Arg  Arg Val Gly 
    1760                 1765                 1770             


Glu Glu  Thr Val Gly Asp Asn  Ser Pro Ser Ser Val  Val Glu Glu 
    1775                 1780                 1785             


Gln Tyr  Leu Asn Lys Leu Thr  Ser Cys Pro Gln Pro  Leu Asn Glu 
    1790                 1795                 1800             


Thr Ser  Tyr Ser Lys Ile Ala  Leu Asp Gly Lys Thr  Thr Ile Ser 
    1805                 1810                 1815             


Ser Thr  Ser Glu Tyr Glu Arg  Asn Arg Gly Glu Arg  Arg Ser His 
    1820                 1825                 1830             


Lys Lys  Phe Lys Pro Asn Val  Thr Arg Gly Arg Gly  Ser Lys Arg 
    1835                 1840                 1845             


Val Arg  Gly Lys Thr Ser Lys  Lys Glu Pro Arg Ala  Ser Lys Ala 
    1850                 1855                 1860             


Met Leu  Val Thr Leu Arg Ala  Ser Gln Glu Glu Asp  Asp Asp Ala 
    1865                 1870                 1875             


Asp Asp  Phe Glu Ser Asp Tyr  Glu Glu Glu Ser Tyr  His Leu Ala 
    1880                 1885                 1890             


Pro Glu  Glu Val Asn Lys Ala  Pro Val Phe Val Pro  Val Gly Leu 
    1895                 1900                 1905             


Arg Ser  Pro Glu Pro Val Ser  Ala Gln Ile Glu Glu  Thr Met Glu 
    1910                 1915                 1920             


Glu Leu  Glu Ile Thr Val Asn  Val Pro Asp Val Gly  Cys Ile Ala 
    1925                 1930                 1935             


Val Val  Glu His Glu Leu Pro  Asn Thr Asp Val Thr  Thr Glu Glu 
    1940                 1945                 1950             


Met Lys  Gln Glu Glu Asn Leu  Ser Val Pro Phe Glu  Met Thr Thr 
    1955                 1960                 1965             


Ser Glu  His Ile Gln Asp Glu  Pro Gly Thr Asn Asp  Gly Ser Thr 
    1970                 1975                 1980             


Glu Ala  Ala Ile Thr Leu Leu  Thr Met Gly Asp Leu  Val Leu Gln 
    1985                 1990                 1995             


Ser Glu  Ile Ser Ser Glu Gln  Gly Asp Val Gly Val  Cys Ile Leu 
    2000                 2005                 2010             


Pro His  Val His Ser Lys Asp  Lys Ser His Ile Pro  Ser Ser Leu 
    2015                 2020                 2025             


Asp Asn  Val Asn His Lys Ile  Val His Glu Cys Gln  Glu Leu Ser 
    2030                 2035                 2040             


Ser Pro  Val Ile Thr Thr Ser  Pro Ala Ser Phe Glu  Glu Asn Lys 
    2045                 2050                 2055             


Ile Val  Leu Glu Glu Gln Ser  Ser Arg Glu Glu Ile  Ser Leu Met 
    2060                 2065                 2070             


Glu Lys  Val Lys Glu Asn Ala  Thr Pro Thr Arg Asn  Thr Ile Ser 
    2075                 2080                 2085             


Lys Val  Thr Ser Asn Leu Arg  Ile Arg Ser Arg Leu  Ala Lys Pro 
    2090                 2095                 2100             


Lys Pro  Asn Leu Glu Lys Thr  Leu Gly Thr Asn Arg  Leu Asp Asp 
    2105                 2110                 2115             


Tyr Gln  Glu Val Ser Ser Leu  Cys Val Thr Lys Gly  Ala Glu Met 
    2120                 2125                 2130             


Glu Thr  Gln Arg Glu Thr Glu  Lys Asn Ala Ser Lys  Ala Thr Glu 
    2135                 2140                 2145             


Leu Glu  Asn Lys Asn Leu Gly  Pro Val Thr Thr Ala  Glu Asn Lys 
    2150                 2155                 2160             


Asp Gln  Ser Lys Leu Ala Cys  Val His Gly Ile Lys  Gly Thr Ser 
    2165                 2170                 2175             


Ile Ser  Ser Glu Val Asn Leu  Thr Glu Arg Asn Glu  Asn Gln Glu 
    2180                 2185                 2190             


Glu Ser  Ser Gln Glu Val His  Met Leu Ser Val Ala  Pro Val Ala 
    2195                 2200                 2205             


Ser Ser  Glu Thr Gly Pro Cys  Thr Leu Gly Leu Asp  Arg Gly Leu 
    2210                 2215                 2220             


Gly Glu  Asn Ser Val Glu Glu  Pro Gln Ile Lys Asp  Ser Lys Gly 
    2225                 2230                 2235             


Asp Ser  Val Leu Thr Leu Pro  Val Pro Glu Tyr Thr  Pro Thr Ser 
    2240                 2245                 2250             


Ile Pro  Glu Val Gln Gln Glu  Asn Ile Ile Asn Pro  Gln Asp Leu 
    2255                 2260                 2265             


Thr Val  Asn Leu Val Ala Asn  Val Pro Gln Asp Gly  Glu Asp Glu 
    2270                 2275                 2280             


Gln Ala  Phe Ile Leu Thr Leu  Val Glu Ile Pro Ala  Asn Ala Val 
    2285                 2290                 2295             


Glu Glu  Phe Thr Asp Ala Thr  Ala Gln Phe Met Pro  Asn Pro Leu 
    2300                 2305                 2310             


Leu Pro  Ala Pro Ile Leu Val  Lys Ser Val Asn Thr  Glu Glu Arg 
    2315                 2320                 2325             


Gly Asp  Met Ser Ile Cys Leu  Pro Ala Thr Ser Val  Gly Gln Asp 
    2330                 2335                 2340             


Ala Met  Gly Leu Ser Ile Ser  Gly Arg Asp Asn Ser  Lys Lys Pro 
    2345                 2350                 2355             


Pro Asp  Asn Leu Asp Leu Val  Ser Arg Lys Arg Phe  Gln Cys Arg 
    2360                 2365                 2370             


Leu Asp  Lys Asn Asp His Ile  Pro Pro Ala Lys Lys  Arg Ser Leu 
    2375                 2380                 2385             


Thr Leu  Arg Asp Asp Cys Gln  Glu Tyr Thr Thr Glu  Val His Ser 
    2390                 2395                 2400             


Lys Glu  Leu Thr Asn Val Phe  Glu Glu Thr Gly Glu  Ser His Lys 
    2405                 2410                 2415             


Gly Gln  Asp Ile Phe Leu Thr  Ser Gly Ser Thr Leu  Thr Thr Pro 
    2420                 2425                 2430             


Glu Pro  Gln Arg Gln Gln Val  Glu Ala Ala Phe Gln  Ser Arg Gly 
    2435                 2440                 2445             


Ser Arg  Ser Pro Asp Ala Cys  Met Asp Lys Asn Val  Pro Gln Leu 
    2450                 2455                 2460             


Pro Gln  Asp Glu Met Ile Val  Ser Asp Lys Glu Glu  Arg Thr Asp 
    2465                 2470                 2475             


Ala Ala  Pro Lys Ser Gln Gln  Met Asp Ser Arg Thr  Ser Ser Ser 
    2480                 2485                 2490             


Lys Ala  Ser Leu Ser Arg Pro  Gly Arg Arg Pro Leu  Gly Phe Leu 
    2495                 2500                 2505             


Ser Leu  Ile Cys Ser Lys Asn  Ser Leu Glu Ser Asp  Glu Pro Met 
    2510                 2515                 2520             


Gln Val  His Ser Lys Lys Arg  Leu Lys Pro Leu Ile  Pro Gly Leu 
    2525                 2530                 2535             


Arg Lys  Lys Leu Lys Arg Ser  Asn Pro Phe Asn Glu  Ser Gln Glu 
    2540                 2545                 2550             


Lys Asn  Arg Glu Ser Ser Asp  Leu Leu Pro Ser Pro  Ser Val Ile 
    2555                 2560                 2565             


Thr Thr  Gln Ser Glu Asn Ile  Ser Ser Ser Ala Thr  Gln Val Ser 
    2570                 2575                 2580             


Cys Asp  Gln Pro Leu Leu Lys  Glu Gly Tyr Lys Ser  Ala Gln Lys 
    2585                 2590                 2595             


Arg Ala  Pro Gln Gly Glu Ala  Thr Thr Val Ser Glu  Tyr Phe Phe 
    2600                 2605                 2610             


Asn Asp  Ile Phe Ile Glu Val  Asp Glu Thr Glu 
    2615                 2620                 


<210>  108
<211>  638
<212>  PRT
<213>  Homo sapiens

<400>  108

Met Asp Leu Trp Gln Leu Leu Leu Thr Leu Ala Leu Ala Gly Ser Ser 
1               5                   10                  15      


Asp Ala Phe Ser Gly Ser Glu Ala Thr Ala Ala Ile Leu Ser Arg Ala 
            20                  25                  30          


Pro Trp Ser Leu Gln Ser Val Asn Pro Gly Leu Lys Thr Asn Ser Ser 
        35                  40                  45              


Lys Glu Pro Lys Phe Thr Lys Cys Arg Ser Pro Glu Arg Glu Thr Phe 
    50                  55                  60                  


Ser Cys His Trp Thr Asp Glu Val His His Gly Thr Lys Asn Leu Gly 
65                  70                  75                  80  


Pro Ile Gln Leu Phe Tyr Thr Arg Arg Asn Thr Gln Glu Trp Thr Gln 
                85                  90                  95      


Glu Trp Lys Glu Cys Pro Asp Tyr Val Ser Ala Gly Glu Asn Ser Cys 
            100                 105                 110         


Tyr Phe Asn Ser Ser Phe Thr Ser Ile Trp Ile Pro Tyr Cys Ile Lys 
        115                 120                 125             


Leu Thr Ser Asn Gly Gly Thr Val Asp Glu Lys Cys Phe Ser Val Asp 
    130                 135                 140                 


Glu Ile Val Gln Pro Asp Pro Pro Ile Ala Leu Asn Trp Thr Leu Leu 
145                 150                 155                 160 


Asn Val Ser Leu Thr Gly Ile His Ala Asp Ile Gln Val Arg Trp Glu 
                165                 170                 175     


Ala Pro Arg Asn Ala Asp Ile Gln Lys Gly Trp Met Val Leu Glu Tyr 
            180                 185                 190         


Glu Leu Gln Tyr Lys Glu Val Asn Glu Thr Lys Trp Lys Met Met Asp 
        195                 200                 205             


Pro Ile Leu Thr Thr Ser Val Pro Val Tyr Ser Leu Lys Val Asp Lys 
    210                 215                 220                 


Glu Tyr Glu Val Arg Val Arg Ser Lys Gln Arg Asn Ser Gly Asn Tyr 
225                 230                 235                 240 


Gly Glu Phe Ser Glu Val Leu Tyr Val Thr Leu Pro Gln Met Ser Gln 
                245                 250                 255     


Phe Thr Cys Glu Glu Asp Phe Tyr Phe Pro Trp Leu Leu Ile Ile Ile 
            260                 265                 270         


Phe Gly Ile Phe Gly Leu Thr Val Met Leu Phe Val Phe Leu Phe Ser 
        275                 280                 285             


Lys Gln Gln Arg Ile Lys Met Leu Ile Leu Pro Pro Val Pro Val Pro 
    290                 295                 300                 


Lys Ile Lys Gly Ile Asp Pro Asp Leu Leu Lys Glu Gly Lys Leu Glu 
305                 310                 315                 320 


Glu Val Asn Thr Ile Leu Ala Ile His Asp Ser Tyr Lys Pro Glu Phe 
                325                 330                 335     


His Ser Asp Asp Ser Trp Val Glu Phe Ile Glu Leu Asp Ile Asp Glu 
            340                 345                 350         


Pro Asp Glu Lys Thr Glu Glu Ser Asp Thr Asp Arg Leu Leu Ser Ser 
        355                 360                 365             


Asp His Glu Lys Ser His Ser Asn Leu Gly Val Lys Asp Gly Asp Ser 
    370                 375                 380                 


Gly Arg Thr Ser Cys Cys Glu Pro Asp Ile Leu Glu Thr Asp Phe Asn 
385                 390                 395                 400 


Ala Asn Asp Ile His Glu Gly Thr Ser Glu Val Ala Gln Pro Gln Arg 
                405                 410                 415     


Leu Lys Gly Glu Ala Asp Leu Leu Cys Leu Asp Gln Lys Asn Gln Asn 
            420                 425                 430         


Asn Ser Pro Tyr His Asp Ala Cys Pro Ala Thr Gln Gln Pro Ser Val 
        435                 440                 445             


Ile Gln Ala Glu Lys Asn Lys Pro Gln Pro Leu Pro Thr Glu Gly Ala 
    450                 455                 460                 


Glu Ser Thr His Gln Ala Ala His Ile Gln Leu Ser Asn Pro Ser Ser 
465                 470                 475                 480 


Leu Ser Asn Ile Asp Phe Tyr Ala Gln Val Ser Asp Ile Thr Pro Ala 
                485                 490                 495     


Gly Ser Val Val Leu Ser Pro Gly Gln Lys Asn Lys Ala Gly Met Ser 
            500                 505                 510         


Gln Cys Asp Met His Pro Glu Met Val Ser Leu Cys Gln Glu Asn Phe 
        515                 520                 525             


Leu Met Asp Asn Ala Tyr Phe Cys Glu Ala Asp Ala Lys Lys Cys Ile 
    530                 535                 540                 


Pro Val Ala Pro His Ile Lys Val Glu Ser His Ile Gln Pro Ser Leu 
545                 550                 555                 560 


Asn Gln Glu Asp Ile Tyr Ile Thr Thr Glu Ser Leu Thr Thr Ala Ala 
                565                 570                 575     


Gly Arg Pro Gly Thr Gly Glu His Val Pro Gly Ser Glu Met Pro Val 
            580                 585                 590         


Pro Asp Tyr Thr Ser Ile His Ile Val Gln Ser Pro Gln Gly Leu Ile 
        595                 600                 605             


Leu Asn Ala Thr Ala Leu Pro Leu Pro Asp Lys Glu Phe Leu Ser Ser 
    610                 615                 620                 


Cys Gly Tyr Val Ser Thr Asp Gln Leu Asn Lys Ile Met Pro 
625                 630                 635             


<210>  109
<211>  643
<212>  PRT
<213>  Homo sapiens

<400>  109

Met Ala Ala Val Leu Ala Leu Arg Val Val Ala Gly Leu Ala Ala Ala 
1               5                   10                  15      


Ala Leu Val Ala Met Leu Leu Glu His Tyr Gly Leu Ala Gly Gln Pro 
            20                  25                  30          


Ser Pro Leu Pro Arg Pro Ala Pro Pro Arg Arg Pro His Pro Ala Pro 
        35                  40                  45              


Gly Pro Gly Asp Ser Asn Ile Phe Trp Gly Leu Gln Ile Ser Asp Ile 
    50                  55                  60                  


His Leu Ser Arg Phe Arg Asp Pro Gly Arg Ala Val Asp Leu Glu Lys 
65                  70                  75                  80  


Phe Cys Ser Glu Thr Ile Asp Ile Ile Gln Pro Ala Leu Val Leu Ala 
                85                  90                  95      


Thr Gly Asp Leu Thr Asp Ala Lys Thr Lys Glu Gln Leu Gly Ser Arg 
            100                 105                 110         


Gln His Glu Val Glu Trp Gln Thr Tyr Gln Gly Ile Leu Lys Lys Thr 
        115                 120                 125             


Arg Val Met Glu Lys Thr Lys Trp Leu Asp Ile Lys Gly Asn His Asp 
    130                 135                 140                 


Ala Phe Asn Ile Pro Ser Leu Asp Ser Ile Lys Asn Tyr Tyr Arg Lys 
145                 150                 155                 160 


Tyr Ser Ala Val Arg Arg Asp Gly Ser Phe His Tyr Val His Ser Thr 
                165                 170                 175     


Pro Phe Gly Asn Tyr Ser Phe Ile Cys Val Asp Ala Thr Val Asn Pro 
            180                 185                 190         


Gly Pro Lys Arg Pro Tyr Asn Phe Phe Gly Ile Leu Asp Lys Lys Lys 
        195                 200                 205             


Met Glu Glu Leu Leu Leu Leu Ala Lys Glu Ser Ser Arg Ser Asn His 
    210                 215                 220                 


Thr Ile Trp Phe Gly His Phe Thr Thr Ser Thr Ile Leu Ser Pro Ser 
225                 230                 235                 240 


Pro Gly Ile Arg Ser Ile Met Ser Ser Ala Ile Ala Tyr Leu Cys Gly 
                245                 250                 255     


His Leu His Thr Leu Gly Gly Leu Met Pro Val Leu His Thr Arg His 
            260                 265                 270         


Phe Gln Gly Thr Leu Glu Leu Glu Val Gly Asp Trp Lys Asp Asn Arg 
        275                 280                 285             


Arg Tyr Arg Ile Phe Ala Phe Asp His Asp Leu Phe Ser Phe Ala Asp 
    290                 295                 300                 


Leu Ile Phe Gly Lys Trp Pro Val Val Leu Ile Thr Asn Pro Lys Ser 
305                 310                 315                 320 


Leu Leu Tyr Ser Cys Gly Glu His Glu Pro Leu Glu Arg Leu Leu His 
                325                 330                 335     


Ser Thr His Ile Arg Val Leu Ala Phe Ser Leu Ser Ser Ile Thr Ser 
            340                 345                 350         


Val Thr Val Lys Ile Asp Gly Val His Leu Gly Gln Ala Val His Val 
        355                 360                 365             


Ser Gly Pro Ile Phe Val Leu Lys Trp Asn Pro Arg Asn Tyr Ser Ser 
    370                 375                 380                 


Gly Thr His Asn Ile Glu Val Ile Val Gln Asp Ser Ala Gly Arg Ser 
385                 390                 395                 400 


Lys Ser Val His His Ile Phe Ser Val Gln Glu Asn Asn His Leu Ser 
                405                 410                 415     


Phe Asp Pro Leu Ala Ser Phe Ile Leu Arg Thr Asp His Tyr Ile Met 
            420                 425                 430         


Ala Arg Val Leu Phe Val Leu Ile Val Leu Ser Gln Leu Thr Ile Leu 
        435                 440                 445             


Ile Ile Phe Arg Tyr Arg Gly Tyr Pro Glu Leu Lys Glu Pro Ser Gly 
    450                 455                 460                 


Phe Ile Asn Leu Thr Ser Phe Ser Leu His Val Leu Ser Lys Ile Asn 
465                 470                 475                 480 


Ile Phe Tyr Tyr Ser Val Leu Leu Leu Thr Leu Tyr Thr Val Leu Gly 
                485                 490                 495     


Pro Trp Phe Phe Gly Glu Ile Ile Asp Gly Lys Phe Gly Cys Cys Phe 
            500                 505                 510         


Ser Phe Gly Ile Phe Val Asn Gly His Phe Leu Gln Gly Ser Ile Thr 
        515                 520                 525             


Phe Ile Ile Gly Ile Leu Gln Leu Ala Phe Phe Asn Ile Pro Leu Met 
    530                 535                 540                 


Ala Tyr Met Cys Trp Ser Leu Leu Gln Arg Cys Phe Gly His Asn Phe 
545                 550                 555                 560 


Arg Ser His Leu His Gln Arg Lys Tyr Leu Lys Ile Met Pro Val His 
                565                 570                 575     


Leu Leu Met Leu Leu Leu Tyr Ile Trp Gln Val Tyr Ser Cys Tyr Phe 
            580                 585                 590         


Leu Tyr Ala Thr Tyr Gly Thr Leu Ala Phe Leu Phe Ser Pro Leu Arg 
        595                 600                 605             


Thr Trp Leu Thr Leu Leu Thr Pro Val Leu Ile Arg Tyr Val Trp Thr 
    610                 615                 620                 


Leu Asn Ser Thr Lys Phe Gly Ile Phe Met Val Gln Leu Lys Ser His 
625                 630                 635                 640 


Leu Ser Ser 
            


<210>  110
<211>  3546
<212>  PRT
<213>  Homo sapiens

<400>  110

Met Cys Glu Asn Cys Ala Asp Leu Val Glu Val Leu Asn Glu Ile Ser 
1               5                   10                  15      


Asp Val Glu Gly Gly Asp Gly Leu Gln Leu Arg Lys Glu His Thr Leu 
            20                  25                  30          


Lys Ile Phe Thr Tyr Ile Asn Ser Trp Thr Gln Arg Gln Cys Leu Cys 
        35                  40                  45              


Cys Phe Lys Glu Tyr Lys His Leu Glu Ile Phe Asn Gln Val Val Cys 
    50                  55                  60                  


Ala Leu Ile Asn Leu Val Ile Ala Gln Val Gln Val Leu Arg Asp Gln 
65                  70                  75                  80  


Leu Cys Lys His Cys Thr Thr Ile Asn Ile Asp Ser Thr Trp Gln Asp 
                85                  90                  95      


Glu Ser Asn Gln Ala Glu Glu Pro Leu Asn Ile Asp Arg Glu Cys Asn 
            100                 105                 110         


Glu Gly Ser Thr Glu Arg Gln Lys Ser Ile Glu Lys Lys Ser Asn Ser 
        115                 120                 125             


Thr Arg Ile Cys Asn Leu Thr Glu Glu Glu Ser Ser Lys Ser Ser Asp 
    130                 135                 140                 


Pro Phe Ser Leu Trp Ser Thr Asp Glu Lys Glu Lys Leu Leu Leu Cys 
145                 150                 155                 160 


Val Ala Lys Ile Phe Gln Ile Gln Phe Pro Leu Tyr Thr Ala Tyr Lys 
                165                 170                 175     


His Asn Thr His Pro Thr Ile Glu Asp Ile Ser Thr Gln Glu Ser Asn 
            180                 185                 190         


Ile Leu Gly Ala Phe Cys Asp Met Asn Asp Val Glu Val Pro Leu His 
        195                 200                 205             


Leu Leu Arg Tyr Val Cys Leu Phe Cys Gly Lys Asn Gly Leu Ser Leu 
    210                 215                 220                 


Met Lys Asp Cys Phe Glu Tyr Gly Thr Pro Glu Thr Leu Pro Phe Leu 
225                 230                 235                 240 


Ile Ala His Ala Phe Ile Thr Val Val Ser Asn Ile Arg Ile Trp Leu 
                245                 250                 255     


His Ile Pro Ala Val Met Gln His Ile Ile Pro Phe Arg Thr Tyr Val 
            260                 265                 270         


Ile Arg Tyr Leu Cys Lys Leu Ser Asp Gln Glu Leu Arg Gln Ser Ala 
        275                 280                 285             


Ala Arg Asn Met Ala Asp Leu Met Trp Ser Thr Val Lys Glu Pro Leu 
    290                 295                 300                 


Asp Thr Thr Leu Cys Phe Asp Lys Glu Ser Leu Asp Leu Ala Phe Lys 
305                 310                 315                 320 


Tyr Phe Met Ser Pro Thr Leu Thr Met Arg Leu Ala Gly Leu Ser Gln 
                325                 330                 335     


Ile Thr Asn Gln Leu His Thr Phe Asn Asp Val Cys Asn Asn Glu Ser 
            340                 345                 350         


Leu Val Ser Asp Thr Glu Thr Ser Ile Ala Lys Glu Leu Ala Asp Trp 
        355                 360                 365             


Leu Ile Ser Asn Asn Val Val Glu His Ile Phe Gly Pro Asn Leu His 
    370                 375                 380                 


Ile Glu Ile Ile Lys Gln Cys Gln Val Ile Leu Asn Phe Leu Ala Ala 
385                 390                 395                 400 


Glu Gly Arg Leu Ser Thr Gln His Ile Asp Cys Ile Trp Ala Ala Ala 
                405                 410                 415     


Gln Leu Lys His Cys Ser Arg Tyr Ile His Asp Leu Phe Pro Ser Leu 
            420                 425                 430         


Ile Lys Asn Leu Asp Pro Val Pro Leu Arg His Leu Leu Asn Leu Val 
        435                 440                 445             


Ser Ala Leu Glu Pro Ser Val His Thr Glu Gln Thr Leu Tyr Leu Ala 
    450                 455                 460                 


Ser Met Leu Ile Lys Ala Leu Trp Asn Asn Ala Leu Ala Ala Lys Ala 
465                 470                 475                 480 


Gln Leu Ser Lys Gln Ser Ser Phe Ala Ser Leu Leu Asn Thr Asn Ile 
                485                 490                 495     


Pro Ile Gly Asn Lys Lys Glu Glu Glu Glu Leu Arg Arg Thr Ala Pro 
            500                 505                 510         


Ser Pro Trp Ser Pro Ala Ala Ser Pro Gln Ser Ser Asp Asn Ser Asp 
        515                 520                 525             


Thr His Gln Ser Gly Gly Ser Asp Ile Glu Met Asp Glu Gln Leu Ile 
    530                 535                 540                 


Asn Arg Thr Lys His Val Gln Gln Arg Leu Ser Asp Thr Glu Glu Ser 
545                 550                 555                 560 


Met Gln Gly Ser Ser Asp Glu Thr Ala Asn Ser Gly Glu Asp Gly Ser 
                565                 570                 575     


Ser Gly Pro Gly Ser Ser Ser Gly His Ser Asp Gly Ser Ser Asn Glu 
            580                 585                 590         


Val Asn Ser Ser His Ala Ser Gln Ser Ala Gly Ser Pro Gly Ser Glu 
        595                 600                 605             


Val Gln Ser Glu Asp Ile Ala Asp Ile Glu Ala Leu Lys Glu Glu Asp 
    610                 615                 620                 


Glu Asp Asp Asp His Gly His Asn Pro Pro Lys Ser Ser Cys Gly Thr 
625                 630                 635                 640 


Asp Leu Arg Asn Arg Lys Leu Glu Ser Gln Ala Gly Ile Cys Leu Gly 
                645                 650                 655     


Asp Ser Gln Gly Met Ser Glu Arg Asn Gly Thr Ser Ser Gly Thr Gly 
            660                 665                 670         


Lys Asp Leu Val Phe Asn Thr Glu Ser Leu Pro Ser Val Asp Asn Arg 
        675                 680                 685             


Met Arg Met Leu Asp Ala Cys Ser His Ser Glu Asp Pro Glu His Asp 
    690                 695                 700                 


Ile Ser Gly Glu Met Asn Ala Thr His Ile Ala Gln Gly Ser Gln Glu 
705                 710                 715                 720 


Ser Cys Ile Thr Arg Thr Gly Asp Phe Leu Gly Glu Thr Ile Gly Asn 
                725                 730                 735     


Glu Leu Phe Asn Cys Arg Gln Phe Ile Gly Pro Gln His His His His 
            740                 745                 750         


His His His His His His His His Asp Gly His Met Val Asp Asp Met 
        755                 760                 765             


Leu Ser Ala Asp Asp Val Ser Cys Ser Ser Ser Gln Val Ser Ala Lys 
    770                 775                 780                 


Ser Glu Lys Asn Met Ala Asp Phe Asp Gly Glu Glu Ser Gly Cys Glu 
785                 790                 795                 800 


Glu Glu Leu Val Gln Ile Asn Ser His Ala Glu Leu Thr Ser His Leu 
                805                 810                 815     


Gln Gln His Leu Pro Asn Leu Ala Ser Ile Tyr His Glu His Leu Ser 
            820                 825                 830         


Gln Gly Pro Val Val His Lys His Gln Phe Asn Ser Asn Ala Val Thr 
        835                 840                 845             


Asp Ile Asn Leu Asp Asn Val Cys Lys Lys Gly Asn Thr Leu Leu Trp 
    850                 855                 860                 


Asp Ile Val Gln Asp Glu Asp Ala Val Asn Leu Ser Glu Gly Leu Ile 
865                 870                 875                 880 


Asn Glu Ala Glu Lys Leu Leu Cys Ser Leu Val Cys Trp Phe Thr Asp 
                885                 890                 895     


Arg Gln Ile Arg Met Arg Phe Ile Glu Gly Cys Leu Glu Asn Leu Gly 
            900                 905                 910         


Asn Asn Arg Ser Val Val Ile Ser Leu Arg Leu Leu Pro Lys Leu Phe 
        915                 920                 925             


Gly Thr Phe Gln Gln Phe Gly Ser Ser Tyr Asp Thr His Trp Ile Thr 
    930                 935                 940                 


Met Trp Ala Glu Lys Glu Leu Asn Met Met Lys Leu Phe Phe Asp Asn 
945                 950                 955                 960 


Leu Val Tyr Tyr Ile Gln Thr Val Arg Glu Gly Arg Gln Lys His Ala 
                965                 970                 975     


Leu Tyr Ser His Ser Ala Glu Val Gln Val Arg Leu Gln Phe Leu Thr 
            980                 985                 990         


Cys Val Phe Ser Thr Leu Gly Ser  Pro Asp His Phe Arg  Leu Ser Leu 
        995                 1000                 1005             


Glu Gln  Val Asp Ile Leu Trp  His Cys Leu Val Glu  Asp Ser Glu 
    1010                 1015                 1020             


Cys Tyr  Asp Asp Ala Leu His  Trp Phe Leu Asn Gln  Val Arg Ser 
    1025                 1030                 1035             


Lys Asp  Gln His Ala Met Gly  Met Glu Thr Tyr Lys  His Leu Phe 
    1040                 1045                 1050             


Leu Glu  Lys Met Pro Gln Leu  Lys Pro Glu Thr Ile  Ser Met Thr 
    1055                 1060                 1065             


Gly Leu  Asn Leu Phe Gln His  Leu Cys Asn Leu Ala  Arg Leu Ala 
    1070                 1075                 1080             


Thr Ser  Ala Tyr Asp Gly Cys  Ser Asn Ser Glu Leu  Cys Gly Met 
    1085                 1090                 1095             


Asp Gln  Phe Trp Gly Ile Ala  Leu Arg Ala Gln Ser  Gly Asp Val 
    1100                 1105                 1110             


Ser Arg  Ala Ala Ile Gln Tyr  Ile Asn Ser Tyr Tyr  Ile Asn Gly 
    1115                 1120                 1125             


Lys Thr  Gly Leu Glu Lys Glu  Gln Glu Phe Ile Ser  Lys Cys Met 
    1130                 1135                 1140             


Glu Ser  Leu Met Ile Ala Ser  Ser Ser Leu Glu Gln  Glu Ser His 
    1145                 1150                 1155             


Ser Ser  Leu Met Val Ile Glu  Arg Gly Leu Leu Met  Leu Lys Thr 
    1160                 1165                 1170             


His Leu  Glu Ala Phe Arg Arg  Arg Phe Ala Tyr His  Leu Arg Gln 
    1175                 1180                 1185             


Trp Gln  Ile Glu Gly Thr Gly  Ile Ser Ser His Leu  Lys Ala Leu 
    1190                 1195                 1200             


Ser Asp  Lys Gln Ser Leu Pro  Leu Arg Val Val Cys  Gln Pro Ala 
    1205                 1210                 1215             


Gly Leu  Pro Asp Lys Met Thr  Ile Glu Met Tyr Pro  Ser Asp Gln 
    1220                 1225                 1230             


Val Ala  Asp Leu Arg Ala Glu  Val Thr His Trp Tyr  Glu Asn Leu 
    1235                 1240                 1245             


Gln Lys  Glu Gln Ile Asn Gln  Gln Ala Gln Leu Gln  Glu Phe Gly 
    1250                 1255                 1260             


Gln Ser  Asn Arg Lys Gly Glu  Phe Pro Gly Gly Leu  Met Gly Pro 
    1265                 1270                 1275             


Val Arg  Met Ile Ser Ser Gly  His Glu Leu Thr Thr  Asp Tyr Asp 
    1280                 1285                 1290             


Glu Lys  Ala Leu His Glu Leu  Gly Phe Lys Asp Met  Gln Met Val 
    1295                 1300                 1305             


Phe Val  Ser Leu Gly Ala Pro  Arg Arg Glu Arg Lys  Gly Glu Gly 
    1310                 1315                 1320             


Val Gln  Leu Pro Ala Ser Cys  Leu Pro Pro Pro Gln  Lys Asp Asn 
    1325                 1330                 1335             


Ile Pro  Met Leu Leu Leu Leu  Gln Glu Pro His Leu  Thr Thr Leu 
    1340                 1345                 1350             


Phe Asp  Leu Leu Glu Met Leu  Ala Ser Phe Lys Pro  Pro Ser Gly 
    1355                 1360                 1365             


Lys Val  Ala Val Asp Asp Ser  Glu Ser Leu Arg Cys  Glu Glu Leu 
    1370                 1375                 1380             


His Leu  His Ala Glu Asn Leu  Ser Arg Arg Val Trp  Glu Leu Leu 
    1385                 1390                 1395             


Met Leu  Leu Pro Thr Cys Pro  Asn Met Leu Met Ala  Phe Gln Asn 
    1400                 1405                 1410             


Ile Ser  Asp Glu Gln Ser Asn  Asp Gly Phe Asn Trp  Lys Glu Leu 
    1415                 1420                 1425             


Leu Lys  Ile Lys Ser Ala His  Lys Leu Leu Tyr Ala  Leu Glu Ile 
    1430                 1435                 1440             


Ile Glu  Ala Leu Gly Lys Pro  Asn Arg Arg Ile Arg  Arg Glu Ser 
    1445                 1450                 1455             


Thr Gly  Ser Tyr Ser Asp Leu  Tyr Pro Asp Ser Asp  Asp Ser Ser 
    1460                 1465                 1470             


Glu Asp  Gln Val Glu Asn Ser  Lys Asn Ser Trp Ser  Cys Lys Phe 
    1475                 1480                 1485             


Val Ala  Ala Gly Gly Leu Gln  Gln Leu Leu Glu Ile  Phe Asn Ser 
    1490                 1495                 1500             


Gly Ile  Leu Glu Pro Lys Glu  Gln Glu Ser Trp Thr  Val Trp Gln 
    1505                 1510                 1515             


Leu Asp  Cys Leu Ala Cys Leu  Leu Lys Leu Ile Cys  Gln Phe Ala 
    1520                 1525                 1530             


Val Asp  Pro Ser Asp Leu Asp  Leu Ala Tyr His Asp  Val Phe Ala 
    1535                 1540                 1545             


Trp Ser  Gly Ile Ala Glu Ser  His Arg Lys Arg Thr  Trp Pro Gly 
    1550                 1555                 1560             


Lys Ser  Arg Lys Ala Ala Gly  Asp His Ala Lys Gly  Leu His Ile 
    1565                 1570                 1575             


Pro Arg  Leu Thr Glu Val Phe  Leu Val Leu Val Gln  Gly Thr Ser 
    1580                 1585                 1590             


Leu Ile  Gln Arg Leu Met Ser  Val Ala Tyr Thr Tyr  Asp Asn Leu 
    1595                 1600                 1605             


Ala Pro  Arg Val Leu Lys Ala  Gln Ser Asp His Arg  Ser Arg His 
    1610                 1615                 1620             


Glu Val  Ser His Tyr Ser Met  Trp Leu Leu Val Ser  Trp Ala His 
    1625                 1630                 1635             


Cys Cys  Ser Leu Val Lys Ser  Ser Leu Ala Asp Ser  Asp His Leu 
    1640                 1645                 1650             


Gln Asp  Trp Leu Lys Lys Leu  Thr Leu Leu Ile Pro  Glu Thr Ala 
    1655                 1660                 1665             


Val Arg  His Glu Ser Cys Ser  Gly Leu Tyr Lys Leu  Ser Leu Ser 
    1670                 1675                 1680             


Gly Leu  Asp Gly Gly Asp Ser  Ile Asn Arg Ser Phe  Leu Leu Leu 
    1685                 1690                 1695             


Ala Ala  Ser Thr Leu Leu Lys  Phe Leu Pro Asp Ala  Gln Ala Leu 
    1700                 1705                 1710             


Lys Pro  Ile Arg Ile Asp Asp  Tyr Glu Glu Glu Pro  Ile Leu Lys 
    1715                 1720                 1725             


Pro Gly  Cys Lys Glu Tyr Phe  Trp Leu Leu Cys Lys  Leu Val Asp 
    1730                 1735                 1740             


Asn Ile  His Ile Lys Asp Ala  Ser Gln Thr Thr Leu  Leu Asp Leu 
    1745                 1750                 1755             


Asp Ala  Leu Ala Arg His Leu  Ala Asp Cys Ile Arg  Ser Arg Glu 
    1760                 1765                 1770             


Ile Leu  Asp His Gln Asp Gly  Asn Val Glu Asp Asp  Gly Leu Thr 
    1775                 1780                 1785             


Gly Leu  Leu Arg Leu Ala Thr  Ser Val Val Lys His  Lys Pro Pro 
    1790                 1795                 1800             


Phe Lys  Phe Ser Arg Glu Gly  Gln Glu Phe Leu Arg  Asp Ile Phe 
    1805                 1810                 1815             


Asn Leu  Leu Phe Leu Leu Pro  Ser Leu Lys Asp Arg  Gln Gln Pro 
    1820                 1825                 1830             


Lys Cys  Lys Ser His Ser Ser  Arg Ala Ala Ala Tyr  Asp Leu Leu 
    1835                 1840                 1845             


Val Glu  Met Val Lys Gly Ser  Val Glu Asn Tyr Arg  Leu Ile His 
    1850                 1855                 1860             


Asn Trp  Val Met Ala Gln His  Met Gln Ser His Ala  Pro Tyr Lys 
    1865                 1870                 1875             


Trp Asp  Tyr Trp Pro His Glu  Asp Val Arg Ala Glu  Cys Arg Phe 
    1880                 1885                 1890             


Val Gly  Leu Thr Asn Leu Gly  Ala Thr Cys Tyr Leu  Ala Ser Thr 
    1895                 1900                 1905             


Ile Gln  Gln Leu Tyr Met Ile  Pro Glu Ala Arg Gln  Ala Val Phe 
    1910                 1915                 1920             


Thr Ala  Lys Tyr Ser Glu Asp  Met Lys His Lys Thr  Thr Leu Leu 
    1925                 1930                 1935             


Glu Leu  Gln Lys Met Phe Thr  Tyr Leu Met Glu Ser  Glu Cys Lys 
    1940                 1945                 1950             


Ala Tyr  Asn Pro Arg Pro Phe  Cys Lys Thr Tyr Thr  Met Asp Lys 
    1955                 1960                 1965             


Gln Pro  Leu Asn Thr Gly Glu  Gln Lys Asp Met Thr  Glu Phe Phe 
    1970                 1975                 1980             


Thr Asp  Leu Ile Thr Lys Ile  Glu Glu Met Ser Pro  Glu Leu Lys 
    1985                 1990                 1995             


Asn Thr  Val Lys Ser Leu Phe  Gly Gly Val Ile Thr  Asn Asn Val 
    2000                 2005                 2010             


Val Ser  Leu Asp Cys Glu His  Val Ser Gln Thr Ala  Glu Glu Phe 
    2015                 2020                 2025             


Tyr Thr  Val Arg Cys Gln Val  Ala Asp Met Lys Asn  Ile Tyr Glu 
    2030                 2035                 2040             


Ser Leu  Asp Glu Val Thr Ile  Lys Asp Thr Leu Glu  Gly Asp Asn 
    2045                 2050                 2055             


Met Tyr  Thr Cys Ser His Cys  Gly Lys Lys Val Arg  Ala Glu Lys 
    2060                 2065                 2070             


Arg Ala  Cys Phe Lys Lys Leu  Pro Arg Ile Leu Ser  Phe Asn Thr 
    2075                 2080                 2085             


Met Arg  Tyr Thr Phe Asn Met  Val Thr Met Met Lys  Glu Lys Val 
    2090                 2095                 2100             


Asn Thr  His Phe Ser Phe Pro  Leu Arg Leu Asp Met  Thr Pro Tyr 
    2105                 2110                 2115             


Thr Glu  Asp Phe Leu Met Gly  Lys Ser Glu Arg Lys  Glu Gly Phe 
    2120                 2125                 2130             


Lys Glu  Val Ser Asp His Ser  Lys Asp Ser Glu Ser  Tyr Glu Tyr 
    2135                 2140                 2145             


Asp Leu  Ile Gly Val Thr Val  His Thr Gly Thr Ala  Asp Gly Gly 
    2150                 2155                 2160             


His Tyr  Tyr Ser Phe Ile Arg  Asp Ile Val Asn Pro  His Ala Tyr 
    2165                 2170                 2175             


Lys Asn  Asn Lys Trp Tyr Leu  Phe Asn Asp Ala Glu  Val Lys Pro 
    2180                 2185                 2190             


Phe Asp  Ser Ala Gln Leu Ala  Ser Glu Cys Phe Gly  Gly Glu Met 
    2195                 2200                 2205             


Thr Thr  Lys Thr Tyr Asp Ser  Val Thr Asp Lys Phe  Met Asp Phe 
    2210                 2215                 2220             


Ser Phe  Glu Lys Thr His Ser  Ala Tyr Met Leu Phe  Tyr Lys Arg 
    2225                 2230                 2235             


Met Glu  Pro Glu Glu Glu Asn  Gly Arg Glu Tyr Lys  Phe Asp Val 
    2240                 2245                 2250             


Ser Ser  Glu Leu Leu Glu Trp  Ile Trp His Asp Asn  Met Gln Phe 
    2255                 2260                 2265             


Leu Gln  Asp Lys Asn Ile Phe  Glu His Thr Tyr Phe  Gly Phe Met 
    2270                 2275                 2280             


Trp Gln  Leu Cys Ser Cys Ile  Pro Ser Thr Leu Pro  Asp Pro Lys 
    2285                 2290                 2295             


Ala Val  Ser Leu Met Thr Ala  Lys Leu Ser Thr Ser  Phe Val Leu 
    2300                 2305                 2310             


Glu Thr  Phe Ile His Ser Lys  Glu Lys Pro Thr Met  Leu Gln Trp 
    2315                 2320                 2325             


Ile Glu  Leu Leu Thr Lys Gln  Phe Asn Asn Ser Gln  Ala Ala Cys 
    2330                 2335                 2340             


Glu Trp  Phe Leu Asp Arg Met  Ala Asp Asp Asp Trp  Trp Pro Met 
    2345                 2350                 2355             


Gln Ile  Leu Ile Lys Cys Pro  Asn Gln Ile Val Arg  Gln Met Phe 
    2360                 2365                 2370             


Gln Arg  Leu Cys Ile His Val  Ile Gln Arg Leu Arg  Pro Val His 
    2375                 2380                 2385             


Ala His  Leu Tyr Leu Gln Pro  Gly Met Glu Asp Gly  Ser Asp Asp 
    2390                 2395                 2400             


Met Asp  Thr Ser Val Glu Asp  Ile Gly Gly Arg Ser  Cys Val Thr 
    2405                 2410                 2415             


Arg Phe  Val Arg Thr Leu Leu  Leu Ile Met Glu His  Gly Val Lys 
    2420                 2425                 2430             


Pro His  Ser Lys His Leu Thr  Glu Tyr Phe Ala Phe  Leu Tyr Glu 
    2435                 2440                 2445             


Phe Ala  Lys Met Gly Glu Glu  Glu Ser Gln Phe Leu  Leu Ser Leu 
    2450                 2455                 2460             


Gln Ala  Ile Ser Thr Met Val  His Phe Tyr Met Gly  Thr Lys Gly 
    2465                 2470                 2475             


Pro Glu  Asn Pro Gln Val Glu  Val Leu Ser Glu Glu  Glu Gly Glu 
    2480                 2485                 2490             


Glu Glu  Glu Glu Glu Glu Asp  Ile Leu Ser Leu Ala  Glu Glu Lys 
    2495                 2500                 2505             


Tyr Arg  Pro Ala Ala Leu Glu  Lys Met Ile Ala Leu  Val Ala Leu 
    2510                 2515                 2520             


Leu Val  Glu Gln Ser Arg Ser  Glu Arg His Leu Thr  Leu Ser Gln 
    2525                 2530                 2535             


Thr Asp  Met Ala Ala Leu Thr  Gly Gly Lys Gly Phe  Pro Phe Leu 
    2540                 2545                 2550             


Phe Gln  His Ile Arg Asp Gly  Ile Asn Ile Arg Gln  Thr Cys Asn 
    2555                 2560                 2565             


Leu Ile  Phe Ser Leu Cys Arg  Tyr Asn Asn Arg Leu  Ala Glu His 
    2570                 2575                 2580             


Ile Val  Ser Met Leu Phe Thr  Ser Ile Ala Lys Leu  Thr Pro Glu 
    2585                 2590                 2595             


Ala Ala  Asn Pro Phe Phe Lys  Leu Leu Thr Met Leu  Met Glu Phe 
    2600                 2605                 2610             


Ala Gly  Gly Pro Pro Gly Met  Pro Pro Phe Ala Ser  Tyr Ile Leu 
    2615                 2620                 2625             


Gln Arg  Ile Trp Glu Val Ile  Glu Tyr Asn Pro Ser  Gln Cys Leu 
    2630                 2635                 2640             


Asp Trp  Leu Ala Val Gln Thr  Pro Arg Asn Lys Leu  Ala His Ser 
    2645                 2650                 2655             


Trp Val  Leu Gln Asn Met Glu  Asn Trp Val Glu Arg  Phe Leu Leu 
    2660                 2665                 2670             


Ala His  Asn Tyr Pro Arg Val  Arg Thr Ser Ala Ala  Tyr Leu Leu 
    2675                 2680                 2685             


Val Ser  Leu Ile Pro Ser Asn  Ser Phe Arg Gln Met  Phe Arg Ser 
    2690                 2695                 2700             


Thr Arg  Ser Leu His Ile Pro  Thr Arg Asp Leu Pro  Leu Ser Pro 
    2705                 2710                 2715             


Asp Thr  Thr Val Val Leu His  Gln Val Tyr Asn Val  Leu Leu Gly 
    2720                 2725                 2730             


Leu Leu  Ser Arg Ala Lys Leu  Tyr Val Asp Ala Ala  Val His Gly 
    2735                 2740                 2745             


Thr Thr  Lys Leu Val Pro Tyr  Phe Ser Phe Met Thr  Tyr Cys Leu 
    2750                 2755                 2760             


Ile Ser  Lys Thr Glu Lys Leu  Met Phe Ser Thr Tyr  Phe Met Asp 
    2765                 2770                 2775             


Leu Trp  Asn Leu Phe Gln Pro  Lys Leu Ser Glu Pro  Ala Ile Ala 
    2780                 2785                 2790             


Thr Asn  His Asn Lys Gln Ala  Leu Leu Ser Phe Trp  Tyr Asn Val 
    2795                 2800                 2805             


Cys Ala  Asp Cys Pro Glu Asn  Ile Arg Leu Ile Val  Gln Asn Pro 
    2810                 2815                 2820             


Val Val  Thr Lys Asn Ile Ala  Phe Asn Tyr Ile Leu  Ala Asp His 
    2825                 2830                 2835             


Asp Asp  Gln Asp Val Val Leu  Phe Asn Arg Gly Met  Leu Pro Ala 
    2840                 2845                 2850             


Tyr Tyr  Gly Ile Leu Arg Leu  Cys Cys Glu Gln Ser  Pro Ala Phe 
    2855                 2860                 2865             


Thr Arg  Gln Leu Ala Ser His  Gln Asn Ile Gln Trp  Ala Phe Lys 
    2870                 2875                 2880             


Asn Leu  Thr Pro His Ala Ser  Gln Tyr Pro Gly Ala  Val Glu Glu 
    2885                 2890                 2895             


Leu Phe  Asn Leu Met Gln Leu  Phe Ile Ala Gln Arg  Pro Asp Met 
    2900                 2905                 2910             


Arg Glu  Glu Glu Leu Glu Asp  Ile Lys Gln Phe Lys  Lys Thr Thr 
    2915                 2920                 2925             


Ile Ser  Cys Tyr Leu Arg Cys  Leu Asp Gly Arg Ser  Cys Trp Thr 
    2930                 2935                 2940             


Thr Leu  Ile Ser Ala Phe Arg  Ile Leu Leu Glu Ser  Asp Glu Asp 
    2945                 2950                 2955             


Arg Leu  Leu Val Val Phe Asn  Arg Gly Leu Ile Leu  Met Thr Glu 
    2960                 2965                 2970             


Ser Phe  Asn Thr Leu His Met  Met Tyr His Glu Ala  Thr Ala Cys 
    2975                 2980                 2985             


His Val  Thr Gly Asp Leu Val  Glu Leu Leu Ser Ile  Phe Leu Ser 
    2990                 2995                 3000             


Val Leu  Lys Ser Thr Arg Pro  Tyr Leu Gln Arg Lys  Asp Val Lys 
    3005                 3010                 3015             


Gln Ala  Leu Ile Gln Trp Gln  Glu Arg Ile Glu Phe  Ala His Lys 
    3020                 3025                 3030             


Leu Leu  Thr Leu Leu Asn Ser  Tyr Ser Pro Pro Glu  Leu Arg Asn 
    3035                 3040                 3045             


Ala Cys  Ile Asp Val Leu Lys  Glu Leu Val Leu Leu  Ser Pro His 
    3050                 3055                 3060             


Asp Phe  Leu His Thr Leu Val  Pro Phe Leu Gln His  Asn His Cys 
    3065                 3070                 3075             


Thr Tyr  His His Ser Asn Ile  Pro Met Ser Leu Gly  Pro Tyr Phe 
    3080                 3085                 3090             


Pro Cys  Arg Glu Asn Ile Lys  Leu Ile Gly Gly Lys  Ser Asn Ile 
    3095                 3100                 3105             


Arg Pro  Pro Arg Pro Glu Leu  Asn Met Cys Leu Leu  Pro Thr Met 
    3110                 3115                 3120             


Val Glu  Thr Ser Lys Gly Lys  Asp Asp Val Tyr Asp  Arg Met Leu 
    3125                 3130                 3135             


Leu Asp  Tyr Phe Phe Ser Tyr  His Gln Phe Ile His  Leu Leu Cys 
    3140                 3145                 3150             


Arg Val  Ala Ile Asn Cys Glu  Lys Phe Thr Glu Thr  Leu Val Lys 
    3155                 3160                 3165             


Leu Ser  Val Leu Val Ala Tyr  Glu Gly Leu Pro Leu  His Leu Ala 
    3170                 3175                 3180             


Leu Phe  Pro Lys Leu Trp Thr  Glu Leu Cys Gln Thr  Gln Ser Ala 
    3185                 3190                 3195             


Met Ser  Lys Asn Cys Ile Lys  Leu Leu Cys Glu Asp  Pro Val Phe 
    3200                 3205                 3210             


Ala Glu  Tyr Ile Lys Cys Ile  Leu Met Asp Glu Arg  Thr Phe Leu 
    3215                 3220                 3225             


Asn Asn  Asn Ile Val Tyr Thr  Phe Met Thr His Phe  Leu Leu Lys 
    3230                 3235                 3240             


Val Gln  Ser Gln Val Phe Ser  Glu Ala Asn Cys Ala  Asn Leu Ile 
    3245                 3250                 3255             


Ser Thr  Leu Ile Thr Asn Leu  Ile Ser Gln Tyr Gln  Asn Leu Gln 
    3260                 3265                 3270             


Ser Asp  Phe Ser Asn Arg Val  Glu Ile Ser Lys Ala  Ser Ala Ser 
    3275                 3280                 3285             


Leu Asn  Gly Asp Leu Arg Ala  Leu Ala Leu Leu Leu  Ser Val His 
    3290                 3295                 3300             


Thr Pro  Lys Gln Leu Asn Pro  Ala Leu Ile Pro Thr  Leu Gln Glu 
    3305                 3310                 3315             


Leu Leu  Ser Lys Cys Arg Thr  Cys Leu Gln Gln Arg  Asn Ser Leu 
    3320                 3325                 3330             


Gln Glu  Gln Glu Ala Lys Glu  Arg Lys Thr Lys Asp  Asp Glu Gly 
    3335                 3340                 3345             


Ala Thr  Pro Ile Lys Arg Arg  Arg Val Ser Ser Asp  Glu Glu His 
    3350                 3355                 3360             


Thr Val  Asp Ser Cys Ile Ser  Asp Met Lys Thr Glu  Thr Arg Glu 
    3365                 3370                 3375             


Val Leu  Thr Pro Thr Ser Thr  Ser Asp Asn Glu Thr  Arg Asp Ser 
    3380                 3385                 3390             


Ser Ile  Ile Asp Pro Gly Thr  Glu Gln Asp Leu Pro  Ser Pro Glu 
    3395                 3400                 3405             


Asn Ser  Ser Val Lys Glu Tyr  Arg Met Glu Val Pro  Ser Ser Phe 
    3410                 3415                 3420             


Ser Glu  Asp Met Ser Asn Ile  Arg Ser Gln His Ala  Glu Glu Gln 
    3425                 3430                 3435             


Ser Asn  Asn Gly Arg Tyr Asp  Asp Cys Lys Glu Phe  Lys Asp Leu 
    3440                 3445                 3450             


His Cys  Ser Lys Asp Ser Thr  Leu Ala Glu Glu Glu  Ser Glu Phe 
    3455                 3460                 3465             


Pro Ser  Thr Ser Ile Ser Ala  Val Leu Ser Asp Leu  Ala Asp Leu 
    3470                 3475                 3480             


Arg Ser  Cys Asp Gly Gln Ala  Leu Pro Ser Gln Asp  Pro Glu Val 
    3485                 3490                 3495             


Ala Leu  Ser Leu Ser Cys Gly  His Ser Arg Gly Leu  Phe Ser His 
    3500                 3505                 3510             


Met Gln  Gln His Asp Ile Leu  Asp Thr Leu Cys Arg  Thr Ile Glu 
    3515                 3520                 3525             


Ser Thr  Ile His Val Val Thr  Arg Ile Ser Gly Lys  Gly Asn Gln 
    3530                 3535                 3540             


Ala Ala  Ser 
    3545     


<210>  111
<211>  389
<212>  PRT
<213>  Homo sapiens

<400>  111

Met Gly Ala Ser Asp Pro Glu Val Ala Pro Trp Ala Arg Gly Gly Ala 
1               5                   10                  15      


Ala Gly Met Ala Gly Ala Gly Ala Gly Ala Gly Ala Arg Gly Gly Ala 
            20                  25                  30          


Ala Ala Gly Val Glu Ala Arg Ala Arg Asp Pro Pro Pro Ala His Arg 
        35                  40                  45              


Ala His Pro Arg His Pro Arg Pro Ala Ala Gln Pro Ser Ala Arg Arg 
    50                  55                  60                  


Met Asp Gly Gly Ser Gly Gly Leu Gly Ser Gly Asp Asn Ala Pro Thr 
65                  70                  75                  80  


Thr Glu Ala Leu Phe Val Ala Leu Gly Ala Gly Val Thr Ala Leu Ser 
                85                  90                  95      


His Pro Leu Leu Tyr Val Lys Leu Leu Ile Gln Val Gly His Glu Pro 
            100                 105                 110         


Met Pro Pro Thr Leu Gly Thr Asn Val Leu Gly Arg Lys Val Leu Tyr 
        115                 120                 125             


Leu Pro Ser Phe Phe Thr Tyr Ala Lys Tyr Ile Val Gln Val Asp Gly 
    130                 135                 140                 


Lys Ile Gly Leu Phe Arg Gly Leu Ser Pro Arg Leu Met Ser Asn Ala 
145                 150                 155                 160 


Leu Ser Thr Val Thr Arg Gly Ser Met Lys Lys Val Phe Pro Pro Asp 
                165                 170                 175     


Glu Ile Glu Gln Val Ser Asn Lys Asp Asp Met Lys Thr Ser Leu Lys 
            180                 185                 190         


Lys Val Val Lys Glu Thr Ser Tyr Glu Met Met Met Gln Cys Val Ser 
        195                 200                 205             


Arg Met Leu Ala His Pro Leu His Val Ile Ser Met Arg Cys Met Val 
    210                 215                 220                 


Gln Phe Val Gly Arg Glu Ala Lys Tyr Ser Gly Val Leu Ser Ser Ile 
225                 230                 235                 240 


Gly Lys Ile Phe Lys Glu Glu Gly Leu Leu Gly Phe Phe Val Gly Leu 
                245                 250                 255     


Ile Pro His Leu Leu Gly Asp Val Val Phe Leu Trp Gly Cys Asn Leu 
            260                 265                 270         


Leu Ala His Phe Ile Asn Ala Tyr Leu Val Asp Asp Ser Val Ser Asp 
        275                 280                 285             


Thr Pro Gly Gly Leu Gly Asn Asp Gln Asn Pro Gly Ser Gln Phe Ser 
    290                 295                 300                 


Gln Ala Leu Ala Ile Arg Ser Tyr Thr Lys Phe Val Met Gly Ile Ala 
305                 310                 315                 320 


Val Ser Met Leu Thr Tyr Pro Phe Leu Leu Val Gly Asp Leu Met Ala 
                325                 330                 335     


Val Asn Asn Cys Gly Leu Gln Ala Gly Leu Pro Pro Tyr Ser Pro Val 
            340                 345                 350         


Phe Lys Ser Trp Ile His Cys Trp Lys Tyr Leu Ser Val Gln Gly Gln 
        355                 360                 365             


Leu Phe Arg Gly Ser Ser Leu Leu Phe Arg Arg Val Ser Ser Gly Ser 
    370                 375                 380                 


Cys Phe Ala Leu Glu 
385                 


<210>  112
<211>  721
<212>  PRT
<213>  herpes simplex virus 7

<400>  112

Met Asn Ser Leu Gln Ser Leu Cys Val Leu Cys Ser Arg Leu Ser Glu 
1               5                   10                  15      


Cys Ala Leu Glu Leu Glu Cys Leu Arg Phe Cys Asp Pro Val Thr Leu 
            20                  25                  30          


Ile Pro Asp Met Thr Asn Phe Arg Lys Asn Gly Val Val Ile Ile His 
        35                  40                  45              


Leu Phe Lys Thr Leu Phe Ala Glu Leu Cys His Gln Asn Phe Asn Cys 
    50                  55                  60                  


Ala Ser Pro Val Thr Ile Tyr Leu Gln Ile Leu Leu Lys Ala Met Tyr 
65                  70                  75                  80  


Asn Gln Val Leu Leu Leu Asp Ala Ser Ile His Gln Phe Leu Leu Asp 
                85                  90                  95      


Asn Asp Lys Gln Lys Tyr Phe Glu Asn Ile Phe Gln Leu Asn Glu Cys 
            100                 105                 110         


Lys Gln His Leu Lys Leu Asp Leu Ala Leu Asn Asn Tyr Leu Thr Phe 
        115                 120                 125             


Ser Val Asp Ile Ser Thr Ile Asn Asp Ile Glu Lys Leu Leu Cys Lys 
    130                 135                 140                 


Met Asn Cys Ile Phe Gly Leu Ile Ser Pro Leu Asp Gly Ile Asn Ala 
145                 150                 155                 160 


Cys Ser Gln Ile Ile Glu Phe Leu Thr Ile Leu Cys Gly Val Cys Val 
                165                 170                 175     


Val Met Lys Pro Glu Val Phe Ser Glu Thr Thr Thr Cys Leu Lys Cys 
            180                 185                 190         


Tyr Glu Glu Leu Ser Leu Val Pro Asn Gln Gly Lys Ser Ile Arg Lys 
        195                 200                 205             


Arg Leu Ala Gly Lys Phe Cys Asn His Leu Thr Glu Thr His Met Val 
    210                 215                 220                 


Ser Asn Leu Glu Lys Asn Val Asp Ile Ile Glu Lys Asp Leu Asp Phe 
225                 230                 235                 240 


Ser Thr Lys Gln Tyr Gly Leu Val Lys Glu Tyr Met Ala Lys Ile Thr 
                245                 250                 255     


Asn Ile Phe Gln Gln Gln Leu Tyr Ser Lys Pro Pro His Leu Gln Glu 
            260                 265                 270         


Ala Glu Asn Thr Leu Ile Asn Phe Asp Leu Phe Ser Lys Ile Pro Asp 
        275                 280                 285             


Thr Ile Tyr Ser Leu Ser Glu Phe Thr Tyr Trp Ser Lys Ile Ser Glu 
    290                 295                 300                 


Ser Val Ile Gln Lys Ala Ser Ile Thr Leu Asn Gln Leu Asn Leu Cys 
305                 310                 315                 320 


His Ser Leu Tyr Ala Asp Leu Gln Asn Glu Ile Ser Lys Phe Leu Tyr 
                325                 330                 335     


Gly Glu Thr Ile Gln Asp Val Phe Asn Phe Asn Glu Glu Asn Val Thr 
            340                 345                 350         


Asn Asp Asp Lys Leu Tyr Ile Gly Ser Arg Phe Ile Ser Pro Cys Arg 
        355                 360                 365             


Leu Val Asp Ile Ile Thr Asn Val Ser Ile Lys Asn Leu Glu Glu Asp 
    370                 375                 380                 


Pro Val Phe Thr Lys Leu Ala Glu Glu Asp Glu Ile Gln Thr Lys Ile 
385                 390                 395                 400 


Lys Thr Leu Leu Asn Glu Leu Glu Asn Ser Ala His Glu Thr Val Pro 
                405                 410                 415     


Lys Lys Tyr Val Thr His Ser Met Thr Gln Asp His Asn Leu Gln Gln 
            420                 425                 430         


Glu Ile His Ile Arg Lys Lys Ala Tyr Tyr Gln Lys Ile Ser Glu Ser 
        435                 440                 445             


Gly Tyr Ser Lys Val Met Leu Cys Ile Lys Glu Gln Glu Ala Leu Ile 
    450                 455                 460                 


Asn Lys Leu Met Asn Ile Asn Ile Leu Gly Asn His Ile Phe Glu Ser 
465                 470                 475                 480 


Leu Ser Lys Met Met Asn Ala Phe Ala Asn Arg Gln Leu Gln Ser Leu 
                485                 490                 495     


Glu Asn Phe Ser Ala Asp Pro Phe Thr Tyr Asp Asp His Leu Tyr Ile 
            500                 505                 510         


Lys Asn Asn Leu Leu Ser Lys Lys Leu Pro Gln Glu Leu Leu Pro Asn 
        515                 520                 525             


Leu Ser Gln Glu Met Tyr Arg Leu Leu Thr Gly Pro Leu Ser Asn Tyr 
    530                 535                 540                 


His Thr Ala Ser Phe Pro Leu Ser Ser Asn Ile Ser Met Ala Tyr Ala 
545                 550                 555                 560 


Cys Asp Val Ala Asp Phe Leu Pro His Met Lys Glu Asp Leu Ala Lys 
                565                 570                 575     


Cys Val Glu Gly Thr Ile Tyr Pro Glu Asn Trp Met Leu Cys Thr Tyr 
            580                 585                 590         


Asn Lys Phe Phe Asn Phe Asp Gly Leu His Asn Ile Asn Asp Met Gln 
        595                 600                 605             


Arg Gln Met Trp Asn Phe Ile Arg Glu Leu Val Leu Ser Val Ala Leu 
    610                 615                 620                 


Tyr Asn Asp Val Phe Gly Lys Gln Leu Ser Ile Val Lys Phe Gly Glu 
625                 630                 635                 640 


Glu Thr Glu Thr Val Glu Lys Ile Leu Leu Thr Phe Asp Ser Gly Ser 
                645                 650                 655     


Pro Leu Leu Phe Lys Arg Gly Thr Thr Thr Thr Lys Phe Asn Asp Leu 
            660                 665                 670         


Tyr Ser Leu Leu Tyr Phe Asp Leu Lys Thr Gln Cys Asp Pro Val Gln 
        675                 680                 685             


Ile Ser Gln Thr Lys Gln Val Ser His Ile Pro Ala Pro Asn Leu Leu 
    690                 695                 700                 


Asp Leu Cys Arg Gln Asn Glu Asn Ser Ile Pro Glu Cys Phe Tyr Asn 
705                 710                 715                 720 


Phe 
    


<210>  113
<211>  967
<212>  PRT
<213>  Homo sapiens

<400>  113

Met Pro Ser Pro Pro Gly Leu Arg Ala Leu Trp Leu Cys Ala Ala Leu 
1               5                   10                  15      


Cys Ala Ser Arg Arg Ala Gly Gly Ala Pro Gln Pro Gly Pro Gly Pro 
            20                  25                  30          


Thr Ala Cys Pro Ala Pro Cys His Cys Gln Glu Asp Gly Ile Met Leu 
        35                  40                  45              


Ser Ala Asp Cys Ser Glu Leu Gly Leu Ser Ala Val Pro Gly Asp Leu 
    50                  55                  60                  


Asp Pro Leu Thr Ala Tyr Leu Asp Leu Ser Met Asn Asn Leu Thr Glu 
65                  70                  75                  80  


Leu Gln Pro Gly Leu Phe His His Leu Arg Phe Leu Glu Glu Leu Arg 
                85                  90                  95      


Leu Ser Gly Asn His Leu Ser His Ile Pro Gly Gln Ala Phe Ser Gly 
            100                 105                 110         


Leu Tyr Ser Leu Lys Ile Leu Met Leu Gln Asn Asn Gln Leu Gly Gly 
        115                 120                 125             


Ile Pro Ala Glu Ala Leu Trp Glu Leu Pro Ser Leu Gln Ser Leu Arg 
    130                 135                 140                 


Leu Asp Ala Asn Leu Ile Ser Leu Val Pro Glu Arg Ser Phe Glu Gly 
145                 150                 155                 160 


Leu Ser Ser Leu Arg His Leu Trp Leu Asp Asp Asn Ala Leu Thr Glu 
                165                 170                 175     


Ile Pro Val Arg Ala Leu Asn Asn Leu Pro Ala Leu Gln Ala Met Thr 
            180                 185                 190         


Leu Ala Leu Asn Arg Ile Ser His Ile Pro Asp Tyr Ala Phe Gln Asn 
        195                 200                 205             


Leu Thr Ser Leu Val Val Leu His Leu His Asn Asn Arg Ile Gln His 
    210                 215                 220                 


Leu Gly Thr His Ser Phe Glu Gly Leu His Asn Leu Glu Thr Leu Asp 
225                 230                 235                 240 


Leu Asn Tyr Asn Lys Leu Gln Glu Phe Pro Val Ala Ile Arg Thr Leu 
                245                 250                 255     


Gly Arg Leu Gln Glu Leu Gly Phe His Asn Asn Asn Ile Lys Ala Ile 
            260                 265                 270         


Pro Glu Lys Ala Phe Met Gly Asn Pro Leu Leu Gln Thr Ile His Phe 
        275                 280                 285             


Tyr Asp Asn Pro Ile Gln Phe Val Gly Arg Ser Ala Phe Gln Tyr Leu 
    290                 295                 300                 


Pro Lys Leu His Thr Leu Ser Leu Asn Gly Ala Met Asp Ile Gln Glu 
305                 310                 315                 320 


Phe Pro Asp Leu Lys Gly Thr Thr Ser Leu Glu Ile Leu Thr Leu Thr 
                325                 330                 335     


Arg Ala Gly Ile Arg Leu Leu Pro Ser Gly Met Cys Gln Gln Leu Pro 
            340                 345                 350         


Arg Leu Arg Val Leu Glu Leu Ser His Asn Gln Ile Glu Glu Leu Pro 
        355                 360                 365             


Ser Leu His Arg Cys Gln Lys Leu Glu Glu Ile Gly Leu Gln His Asn 
    370                 375                 380                 


Arg Ile Trp Glu Ile Gly Ala Asp Thr Phe Ser Gln Leu Ser Ser Leu 
385                 390                 395                 400 


Gln Ala Leu Asp Leu Ser Trp Asn Ala Ile Arg Ser Ile His Pro Glu 
                405                 410                 415     


Ala Phe Ser Thr Leu His Ser Leu Val Lys Leu Asp Leu Thr Asp Asn 
            420                 425                 430         


Gln Leu Thr Thr Leu Pro Leu Ala Gly Leu Gly Gly Leu Met His Leu 
        435                 440                 445             


Lys Leu Lys Gly Asn Leu Ala Leu Ser Gln Ala Phe Ser Lys Asp Ser 
    450                 455                 460                 


Phe Pro Lys Leu Arg Ile Leu Glu Val Pro Tyr Ala Tyr Gln Cys Cys 
465                 470                 475                 480 


Pro Tyr Gly Met Cys Ala Ser Phe Phe Lys Ala Ser Gly Gln Trp Glu 
                485                 490                 495     


Ala Glu Asp Leu His Leu Asp Asp Glu Glu Ser Ser Lys Arg Pro Leu 
            500                 505                 510         


Gly Leu Leu Ala Arg Gln Ala Glu Asn His Tyr Asp Gln Asp Leu Asp 
        515                 520                 525             


Glu Leu Gln Leu Glu Met Glu Asp Ser Lys Pro His Pro Ser Val Gln 
    530                 535                 540                 


Cys Ser Pro Thr Pro Gly Pro Phe Lys Pro Cys Glu Tyr Leu Phe Glu 
545                 550                 555                 560 


Ser Trp Gly Ile Arg Leu Ala Val Trp Ala Ile Val Leu Leu Ser Val 
                565                 570                 575     


Leu Cys Asn Gly Leu Val Leu Leu Thr Val Phe Ala Gly Gly Pro Val 
            580                 585                 590         


Pro Leu Pro Pro Val Lys Phe Val Val Gly Ala Ile Ala Gly Ala Asn 
        595                 600                 605             


Thr Leu Thr Gly Ile Ser Cys Gly Leu Leu Ala Ser Val Asp Ala Leu 
    610                 615                 620                 


Thr Phe Gly Gln Phe Ser Glu Tyr Gly Ala Arg Trp Glu Thr Gly Leu 
625                 630                 635                 640 


Gly Cys Arg Ala Thr Gly Phe Leu Ala Val Leu Gly Ser Glu Ala Ser 
                645                 650                 655     


Val Leu Leu Leu Thr Leu Ala Ala Val Gln Cys Ser Val Ser Val Ser 
            660                 665                 670         


Cys Val Arg Ala Tyr Gly Lys Ser Pro Ser Leu Gly Ser Val Arg Ala 
        675                 680                 685             


Gly Val Leu Gly Cys Leu Ala Leu Ala Gly Leu Ala Ala Ala Leu Pro 
    690                 695                 700                 


Leu Ala Ser Val Gly Glu Tyr Gly Ala Ser Pro Leu Cys Leu Pro Tyr 
705                 710                 715                 720 


Ala Pro Pro Glu Gly Gln Pro Ala Ala Leu Gly Phe Thr Val Ala Leu 
                725                 730                 735     


Val Met Met Asn Ser Phe Cys Phe Leu Val Val Ala Gly Ala Tyr Ile 
            740                 745                 750         


Lys Leu Tyr Cys Asp Leu Pro Arg Gly Asp Phe Glu Ala Val Trp Asp 
        755                 760                 765             


Cys Ala Met Val Arg His Val Ala Trp Leu Ile Phe Ala Asp Gly Leu 
    770                 775                 780                 


Leu Tyr Cys Pro Val Ala Phe Leu Ser Phe Ala Ser Met Leu Gly Leu 
785                 790                 795                 800 


Phe Pro Val Thr Pro Glu Ala Val Lys Ser Val Leu Leu Val Val Leu 
                805                 810                 815     


Pro Leu Pro Ala Cys Leu Asn Pro Leu Leu Tyr Leu Leu Phe Asn Pro 
            820                 825                 830         


His Phe Arg Asp Asp Leu Arg Arg Leu Arg Pro Arg Ala Gly Asp Ser 
        835                 840                 845             


Gly Pro Leu Ala Tyr Ala Ala Ala Gly Glu Leu Glu Lys Ser Ser Cys 
    850                 855                 860                 


Asp Ser Thr Gln Ala Leu Val Ala Phe Ser Asp Val Asp Leu Ile Leu 
865                 870                 875                 880 


Glu Ala Ser Glu Ala Gly Arg Pro Pro Gly Leu Glu Thr Tyr Gly Phe 
                885                 890                 895     


Pro Ser Val Thr Leu Ile Ser Cys Gln Gln Pro Gly Ala Pro Arg Leu 
            900                 905                 910         


Glu Gly Ser His Cys Val Glu Pro Glu Gly Asn His Phe Gly Asn Pro 
        915                 920                 925             


Gln Pro Ser Met Asp Gly Glu Leu Leu Leu Arg Ala Glu Gly Ser Thr 
    930                 935                 940                 


Pro Ala Gly Gly Gly Leu Ser Gly Gly Gly Gly Phe Gln Pro Ser Gly 
945                 950                 955                 960 


Leu Ala Phe Ala Ser His Val 
                965         


<210>  114
<211>  867
<212>  PRT
<213>  Homo sapiens

<400>  114

Met Thr Glu Asn Lys Thr Val Ser Ser Ser Ser Thr Arg Asp Asp Gln 
1               5                   10                  15      


Thr Asn Ile Gly Leu Thr Cys Gln Glu Val Lys Ala Leu Arg Glu Lys 
            20                  25                  30          


Ala Trp Ser Arg Thr Asn Glu Gly Asn Ala Met Ser Gln Ser Leu Val 
        35                  40                  45              


Leu Tyr Gly Ala Ser Lys Glu Asn Ser Glu Gly Phe His Glu Ser Lys 
    50                  55                  60                  


Met Thr Asn Thr Glu Gly Val Asn Lys Gly Ile Tyr Phe Ser Tyr Pro 
65                  70                  75                  80  


Cys Arg Arg His Ser Cys Ala Val Val Asn Ile Pro Ala Pro Cys Val 
                85                  90                  95      


Asn Lys Met Ile Ser His Ile Gln Asp Val Glu Ser Lys Ile Gln Glu 
            100                 105                 110         


His Leu Lys Arg Phe Glu Thr Ser Phe Glu Glu Trp Ser Arg Thr Ser 
        115                 120                 125             


Ser Thr Lys Asp Leu Lys Glu Asp Trp Ser Val Thr Thr Pro Val Lys 
    130                 135                 140                 


Glu Val Lys Pro Gly Glu Lys Arg Asp Glu Lys Cys Pro Glu Leu Lys 
145                 150                 155                 160 


Gln Glu Met Glu Thr Leu Leu Ser Glu Ala Ile Arg Leu Ile Lys Ser 
                165                 170                 175     


Leu Glu Thr Asp Arg Ala Asp Ala Glu Glu Ala Leu Lys Gln Gln Arg 
            180                 185                 190         


Ser Arg Lys Asn Met Ile Asn Met Lys Ile Asp Ser Trp Ser Val Trp 
        195                 200                 205             


Lys Leu Gln Glu Leu Pro Leu Ala Val Gln Lys Glu His Glu Ala Tyr 
    210                 215                 220                 


Leu Ser Asp Val Ile Glu Leu Gln Trp His Leu Glu Asp Lys Ala Asn 
225                 230                 235                 240 


Gln Leu Gln His Phe Glu Lys Gln Lys Thr Glu Leu Glu Glu Ala Asn 
                245                 250                 255     


Ala Lys Ile Gln Ala Asp Ile Asp Tyr Met Asn Glu His Gly Pro Leu 
            260                 265                 270         


Leu Asp Ser Lys Gln Asn Gln Glu Leu Gln Asp Leu Lys Asn His Tyr 
        275                 280                 285             


Lys Lys Lys Met Glu Val Met Asp Leu His Arg Lys Val Asn Glu Glu 
    290                 295                 300                 


Leu Glu Glu Ala Leu Glu Ala Cys Glu Asn Ala Arg Leu Lys Ala Gln 
305                 310                 315                 320 


Gln Ile Lys Glu Glu Ile Asp Lys Asp Ile Tyr Gln Asp Glu Lys Thr 
                325                 330                 335     


Ile Glu Ala Tyr Lys Arg Glu Ile Tyr Gln Leu Asn Ser Leu Phe Asp 
            340                 345                 350         


His Tyr Ser Ser Ser Val Ile Asn Val Asn Thr Asn Ile Glu Glu Lys 
        355                 360                 365             


Glu Glu Glu Val Thr Glu Ala Ile Arg Glu Thr Lys Ser Ser Lys Asn 
    370                 375                 380                 


Glu Leu His Ser Leu Ser Lys Met Leu Glu Asp Leu Arg Arg Val Tyr 
385                 390                 395                 400 


Asp Gln Leu Thr Trp Lys Gln Lys Ser His Glu Asn Gln Tyr Leu Glu 
                405                 410                 415     


Ala Val Asn Asp Phe Tyr Ala Ala Lys Lys Thr Trp Asp Ile Glu Leu 
            420                 425                 430         


Ser Asp Val Ala Lys Asp Phe Ser Ala Ile Ser Leu Ala Cys Thr Lys 
        435                 440                 445             


Leu Thr Glu Asp Asn Lys Lys Leu Glu Ile Asp Ile Asn Lys Ile Thr 
    450                 455                 460                 


Val Lys Thr Asn Glu Ser Ile Arg Lys Lys Ser Lys Tyr Glu Ser Glu 
465                 470                 475                 480 


Ile Lys Tyr Leu Thr Ile Met Lys Leu Lys Asn Asp Lys His Leu Lys 
                485                 490                 495     


Asn Ile Tyr Lys Glu Ala Tyr Arg Ile Gly Thr Leu Phe His Leu Thr 
            500                 505                 510         


Lys His Lys Thr Asp Glu Met Glu Asp Lys Ile Ala Glu Val Arg Arg 
        515                 520                 525             


Lys Phe Lys Gly Arg Glu Glu Phe Leu Lys Lys Leu Thr Gln Gly Glu 
    530                 535                 540                 


Val Ala Ala Gly Met Val Leu Gln Lys Lys Leu Tyr Ser Ile Tyr Glu 
545                 550                 555                 560 


Val Gln Ala Leu Glu Arg Lys Glu Leu Ile Lys Asn Arg Ala Ile Cys 
                565                 570                 575     


Ala Met Ser Leu Ala Glu Leu Gln Glu Pro Leu Leu Gln Leu Glu Asp 
            580                 585                 590         


Glu Ala Glu Arg Ile Arg Ser Leu Asp Lys Glu His Ser Val Met Leu 
        595                 600                 605             


Asn Asn Ile Ile Asp Gln Lys Asp Leu Ile Arg Arg Lys Val Gly Lys 
    610                 615                 620                 


Val Lys Lys Lys Leu Arg Lys Lys Gly Lys Lys Thr Leu Asp Ala Leu 
625                 630                 635                 640 


Ile Glu Thr Glu Ser Lys Arg Ser Ala Ile Phe Lys Asp Leu Glu Ala 
                645                 650                 655     


Thr Lys Ser Lys Thr Met Ile Phe Tyr Ala Lys Ile Asn Glu Leu Asn 
            660                 665                 670         


Glu Glu Leu Lys Ala Lys Glu Glu Glu Lys Lys Ser Phe Asp Gln Thr 
        675                 680                 685             


Leu Glu Ile Leu Lys Asn Lys Phe Ile Thr Met Arg Phe Lys Arg Glu 
    690                 695                 700                 


His Ala Gln Thr Val Phe Asp His Tyr Met Gln Glu Lys Lys Asp Cys 
705                 710                 715                 720 


Glu Glu Arg Ile Phe Glu Glu Asp Gln Arg Phe Arg Val Leu Leu Ala 
                725                 730                 735     


Val Arg Gln Lys Thr Leu Gln Asp Thr Gln Lys Ile Ile Ala Asp Ser 
            740                 745                 750         


Leu Glu Glu Asn Leu Arg Leu Ala Gln Glu Tyr Gln Gln Leu Gln Ile 
        755                 760                 765             


Thr Phe Leu Lys Glu Lys Asp Asn Tyr Phe Asn Ile Tyr Asp Lys Gln 
    770                 775                 780                 


Leu Ser Leu Asp Thr Ser Ile Arg Asp Lys Lys Gln Leu Cys Gln Leu 
785                 790                 795                 800 


Gln Arg Arg Met His Thr Leu Trp Gln Glu His Phe Lys Leu Val Val 
                805                 810                 815     


Leu Phe Ser Gln Met Arg Leu Ala Asn Phe Gln Thr Asp Ser Gln Glu 
            820                 825                 830         


Ser Ile Gln Lys Ile Leu Ala Val Gln Glu Glu Ser Ser Asn Leu Met 
        835                 840                 845             


Gln His Ile Leu Gly Phe Phe Gln Thr Leu Thr Asp Gly Thr Cys Glu 
    850                 855                 860                 


Asn Asp Gly 
865         


<210>  115
<211>  299
<212>  PRT
<213>  Homo sapiens

<400>  115

Met His Ser Leu Ala Thr Ala Ala Pro Val Pro Thr Thr Leu Ala Gln 
1               5                   10                  15      


Val Asp Arg Glu Lys Ile Tyr Gln Trp Ile Asn Glu Leu Ser Ser Pro 
            20                  25                  30          


Glu Thr Arg Glu Asn Ala Leu Leu Glu Leu Ser Lys Lys Arg Glu Ser 
        35                  40                  45              


Val Pro Asp Leu Ala Pro Met Leu Trp His Ser Phe Gly Thr Ile Ala 
    50                  55                  60                  


Ala Leu Leu Gln Glu Ile Val Asn Ile Tyr Pro Ser Ile Asn Pro Pro 
65                  70                  75                  80  


Thr Leu Thr Ala His Gln Ser Asn Arg Val Cys Asn Ala Leu Ala Leu 
                85                  90                  95      


Leu Gln Cys Val Ala Ser His Pro Glu Thr Arg Ser Ala Phe Leu Ala 
            100                 105                 110         


Ala His Ile Pro Leu Phe Leu Tyr Pro Phe Leu His Thr Val Ser Lys 
        115                 120                 125             


Thr Arg Pro Phe Glu Tyr Leu Arg Leu Thr Ser Leu Gly Val Ile Gly 
    130                 135                 140                 


Ala Leu Val Lys Thr Asp Glu Gln Glu Val Ile Asn Phe Leu Leu Thr 
145                 150                 155                 160 


Thr Glu Ile Ile Pro Leu Cys Leu Arg Ile Met Glu Ser Gly Ser Glu 
                165                 170                 175     


Leu Ser Lys Thr Val Ala Thr Phe Ile Leu Gln Lys Ile Leu Leu Asp 
            180                 185                 190         


Asp Thr Gly Leu Ala Tyr Ile Cys Gln Thr Tyr Glu Arg Phe Ser His 
        195                 200                 205             


Val Ala Met Ile Leu Gly Lys Met Val Leu Gln Leu Ser Lys Glu Pro 
    210                 215                 220                 


Ser Ala Arg Leu Leu Lys His Val Val Arg Cys Tyr Leu Arg Leu Ser 
225                 230                 235                 240 


Asp Asn Pro Arg Ala Arg Glu Ala Leu Arg Gln Cys Leu Pro Asp Gln 
                245                 250                 255     


Leu Lys Asp Thr Thr Phe Ala Gln Val Leu Lys Asp Asp Thr Thr Thr 
            260                 265                 270         


Lys Arg Trp Leu Ala Gln Leu Val Lys Asn Leu Gln Glu Gly Gln Val 
        275                 280                 285             


Thr Asp Pro Arg Gly Ile Pro Leu Pro Pro Gln 
    290                 295                 


<210>  116
<211>  438
<212>  PRT
<213>  Homo sapiens

<400>  116

Met Ala Leu Arg Gly Val Ser Val Arg Leu Leu Ser Arg Gly Pro Gly 
1               5                   10                  15      


Leu His Val Leu Arg Thr Trp Val Ser Ser Ala Ala Gln Thr Glu Lys 
            20                  25                  30          


Gly Gly Arg Thr Gln Ser Gln Leu Ala Lys Ser Ser Arg Pro Glu Phe 
        35                  40                  45              


Asp Trp Gln Asp Pro Leu Val Leu Glu Glu Gln Leu Thr Thr Asp Glu 
    50                  55                  60                  


Ile Leu Ile Arg Asp Thr Phe Arg Thr Tyr Cys Gln Glu Arg Leu Met 
65                  70                  75                  80  


Pro Arg Ile Leu Leu Ala Asn Arg Asn Glu Val Phe His Arg Glu Ile 
                85                  90                  95      


Ile Ser Glu Met Gly Glu Leu Gly Val Leu Gly Pro Thr Ile Lys Gly 
            100                 105                 110         


Tyr Gly Cys Ala Gly Val Ser Ser Val Ala Tyr Gly Leu Leu Ala Arg 
        115                 120                 125             


Glu Leu Glu Arg Val Asp Ser Gly Tyr Arg Ser Ala Met Ser Val Gln 
    130                 135                 140                 


Ser Ser Leu Val Met His Pro Ile Tyr Ala Tyr Gly Ser Glu Glu Gln 
145                 150                 155                 160 


Arg Gln Lys Tyr Leu Pro Gln Leu Ala Lys Gly Glu Leu Leu Gly Cys 
                165                 170                 175     


Phe Gly Leu Thr Glu Pro Asn Ser Gly Ser Asp Pro Ser Ser Met Glu 
            180                 185                 190         


Thr Arg Ala His Tyr Asn Ser Ser Asn Lys Ser Tyr Thr Leu Asn Gly 
        195                 200                 205             


Thr Lys Thr Trp Ile Thr Asn Ser Pro Met Ala Asp Leu Phe Val Val 
    210                 215                 220                 


Trp Ala Arg Cys Glu Asp Gly Cys Ile Arg Gly Phe Leu Leu Glu Lys 
225                 230                 235                 240 


Gly Met Arg Gly Leu Ser Ala Pro Arg Ile Gln Gly Lys Phe Ser Leu 
                245                 250                 255     


Arg Ala Ser Ala Thr Gly Met Ile Ile Met Asp Gly Val Glu Val Pro 
            260                 265                 270         


Glu Glu Asn Val Leu Pro Gly Ala Ser Ser Leu Gly Gly Pro Phe Gly 
        275                 280                 285             


Cys Leu Asn Asn Ala Arg Tyr Gly Ile Ala Trp Gly Val Leu Gly Ala 
    290                 295                 300                 


Ser Glu Phe Cys Leu His Thr Ala Arg Gln Tyr Ala Leu Asp Arg Met 
305                 310                 315                 320 


Gln Phe Gly Val Pro Leu Ala Arg Asn Gln Leu Ile Gln Lys Lys Leu 
                325                 330                 335     


Ala Asp Met Leu Thr Glu Ile Thr Leu Gly Leu His Ala Cys Leu Gln 
            340                 345                 350         


Leu Gly Arg Leu Lys Asp Gln Asp Lys Ala Ala Pro Glu Met Val Ser 
        355                 360                 365             


Leu Leu Lys Arg Asn Asn Cys Gly Lys Ala Leu Asp Ile Ala Arg Gln 
    370                 375                 380                 


Ala Arg Asp Met Leu Gly Gly Asn Gly Ile Ser Asp Glu Tyr His Val 
385                 390                 395                 400 


Ile Arg His Ala Met Asn Leu Glu Ala Val Asn Thr Tyr Glu Gly Thr 
                405                 410                 415     


His Asp Ile His Ala Leu Ile Leu Gly Arg Ala Ile Thr Gly Ile Gln 
            420                 425                 430         


Ala Phe Thr Ala Ser Lys 
        435             


<210>  117
<211>  519
<212>  PRT
<213>  Homo sapiens

<400>  117

Met Ala Ala Glu Ala Ala Asp Leu Gly Leu Gly Ala Ala Val Pro Val 
1               5                   10                  15      


Glu Leu Arg Arg Glu Arg Arg Met Val Cys Val Glu Tyr Pro Gly Val 
            20                  25                  30          


Val Arg Asp Val Ala Lys Met Leu Pro Thr Leu Gly Gly Glu Glu Gly 
        35                  40                  45              


Val Ser Arg Ile Tyr Ala Asp Pro Thr Lys Arg Leu Glu Leu Tyr Phe 
    50                  55                  60                  


Arg Pro Lys Asp Pro Tyr Cys His Pro Val Cys Ala Asn Arg Phe Ser 
65                  70                  75                  80  


Thr Ser Ser Leu Leu Leu Arg Ile Arg Lys Arg Thr Arg Arg Gln Lys 
                85                  90                  95      


Gly Val Leu Gly Thr Glu Ala His Ser Glu Val Thr Phe Asp Met Glu 
            100                 105                 110         


Ile Leu Gly Ile Ile Ser Thr Ile Tyr Lys Phe Gln Gly Met Ser Asp 
        115                 120                 125             


Phe Gln Tyr Leu Ala Val His Thr Glu Ala Gly Gly Lys His Thr Ser 
    130                 135                 140                 


Met Tyr Asp Lys Val Leu Met Leu Arg Pro Glu Lys Glu Ala Phe Phe 
145                 150                 155                 160 


His Gln Glu Leu Pro Leu Tyr Ile Pro Pro Pro Ile Phe Ser Arg Leu 
                165                 170                 175     


Asp Ala Pro Val Asp Tyr Phe Tyr Arg Pro Glu Thr Gln His Arg Glu 
            180                 185                 190         


Gly Tyr Asn Asn Pro Pro Ile Ser Gly Glu Asn Leu Ile Gly Leu Ser 
        195                 200                 205             


Arg Ala Arg Arg Pro His Asn Ala Ile Phe Val Asn Phe Glu Asp Glu 
    210                 215                 220                 


Glu Val Pro Lys Gln Pro Leu Glu Ala Ala Ala Gln Thr Trp Arg Arg 
225                 230                 235                 240 


Val Cys Thr Asn Pro Val Asp Arg Lys Val Glu Glu Glu Leu Arg Lys 
                245                 250                 255     


Leu Phe Asp Ile Arg Pro Ile Trp Ser Arg Asn Ala Val Lys Ala Asn 
            260                 265                 270         


Ile Ser Val His Pro Asp Lys Leu Lys Val Leu Leu Pro Phe Ile Ala 
        275                 280                 285             


Tyr Tyr Met Ile Thr Gly Pro Trp Arg Ser Leu Trp Ile Arg Phe Gly 
    290                 295                 300                 


Tyr Asp Pro Arg Lys Asn Pro Asp Ala Lys Ile Tyr Gln Val Leu Asp 
305                 310                 315                 320 


Phe Arg Ile Arg Cys Gly Met Lys His Gly Tyr Ala Pro Ser Asp Leu 
                325                 330                 335     


Pro Val Lys Ala Lys Arg Ser Thr Tyr Asn Tyr Ser Leu Pro Ile Thr 
            340                 345                 350         


Val Lys Lys Thr Ser Ser Gln Leu Val Thr Met His Asp Leu Lys Gln 
        355                 360                 365             


Gly Leu Gly Pro Ser Gly Thr Ser Gly Ala Arg Lys Pro Ala Ser Ser 
    370                 375                 380                 


Lys Tyr Lys Leu Lys Asp Ser Val Tyr Ile Phe Arg Glu Gly Ala Leu 
385                 390                 395                 400 


Pro Pro Tyr Arg Gln Met Phe Tyr Gln Leu Cys Asp Leu Asn Val Glu 
                405                 410                 415     


Glu Leu Gln Lys Ile Ile His Arg Asn Asp Gly Ala Glu Asn Ser Cys 
            420                 425                 430         


Thr Glu Arg Asp Gly Trp Cys Leu Pro Lys Thr Ser Asp Glu Leu Arg 
        435                 440                 445             


Asp Thr Met Ser Leu Met Ile Arg Gln Thr Ile Arg Ser Lys Arg Pro 
    450                 455                 460                 


Ala Leu Phe Ser Ser Ser Ala Lys Ala Asp Gly Gly Lys Glu Gln Leu 
465                 470                 475                 480 


Thr Tyr Glu Ser Gly Glu Asp Glu Glu Asp Glu Glu Glu Glu Glu Glu 
                485                 490                 495     


Glu Glu Glu Asp Phe Lys Pro Ser Asp Gly Ser Glu Asn Glu Met Glu 
            500                 505                 510         


Thr Glu Ile Leu Asp Tyr Val 
        515                 


<210>  118
<211>  373
<212>  PRT
<213>  Homo sapiens

<400>  118

Met Pro Arg Gly Gly Met Asp Asp His Trp Pro Ser Ser Asp Asp Gln 
1               5                   10                  15      


Gly His Asp Pro Lys Glu Pro Glu Gln Leu Arg Lys Leu Phe Ile Gly 
            20                  25                  30          


Gly Leu Ser Phe Glu Thr Thr Asp Asp Ser Leu Arg Glu His Phe Glu 
        35                  40                  45              


Gln Trp Gly Lys Leu Thr Asp Cys Val Val Met Arg Asp Pro Gln Thr 
    50                  55                  60                  


Lys Arg Ser Arg Gly Phe Gly Phe Val Thr Tyr Ser Cys Val Glu Glu 
65                  70                  75                  80  


Val Asp Ala Ser Met Ser Ala Arg Pro His Lys Val Asp Gly Arg Val 
                85                  90                  95      


Val Glu Pro Lys Arg Ala Val Ser Arg Glu Asp Ser Ala Arg Pro Gly 
            100                 105                 110         


Ala His Leu Thr Val Lys Lys Ile Phe Val Gly Gly Ile Lys Glu Asp 
        115                 120                 125             


Thr Glu Glu Tyr His Leu Arg Asp Tyr Ser Glu Ser Tyr Gly Lys Ile 
    130                 135                 140                 


Glu Thr Ile Glu Val Met Glu Asp Arg Gln Ser Gly Lys Lys Arg Gly 
145                 150                 155                 160 


Phe Ala Phe Val Thr Phe Asp Asp His Asp Thr Val Asp Lys Ile Val 
                165                 170                 175     


Val Gln Lys Tyr His Thr Ile Asn Gly His Asn Cys Glu Val Lys Lys 
            180                 185                 190         


Ala Leu Ser Lys Gln Glu Met Gln Thr Ala Ser Ala Gln Arg Gly Arg 
        195                 200                 205             


Gly Gly Gly Gly Ser Asn Phe Met Gly Arg Gly Gly Asn Tyr Gly Gly 
    210                 215                 220                 


Gly Asp Gly Gly Asn Phe Gly Arg Gly Gly Gly Gly Gly Phe Gly Asn 
225                 230                 235                 240 


Arg Gly Gly Tyr Gly Gly Gly Gly Gly Arg Gly Gly Gly Gly Tyr Gly 
                245                 250                 255     


Gly Gly Gly Asp Gly Tyr Asn Gly Phe Gly Gly Asp Gly Gly Asn Tyr 
            260                 265                 270         


Gly Gly Gly Pro Gly Tyr Gly Gly Arg Gly Tyr Gly Gly Ser Pro Gly 
        275                 280                 285             


Tyr Gly Asn Gln Gly Gly Gly Tyr Gly Gly Gly Gly Gly Gly Tyr Asp 
    290                 295                 300                 


Gly Tyr Asn Glu Ser Gly Asn Phe Gly Gly Gly Asn Tyr Asn Asp Phe 
305                 310                 315                 320 


Gly Asn Tyr Gly Gly Gln Gln Gln Ser Asn Tyr Gly Pro Met Lys Gly 
                325                 330                 335     


Gly Ser Phe Ser Gly Arg Ser Ser Gly Gly Ser Gly Ser Gly Pro Tyr 
            340                 345                 350         


Gly Gly Gly Tyr Gly Ser Gly Gly Gly Gly Gly Gly Gly Gly Ser Tyr 
        355                 360                 365             


Gly Gly Arg Arg Phe 
    370             


<210>  119
<211>  589
<212>  PRT
<213>  Homo sapiens

<400>  119

Met Ala Ala Ala Asp Gly Asp Asp Ser Leu Tyr Pro Ile Ala Val Leu 
1               5                   10                  15      


Ile Asp Glu Leu Arg Asn Glu Asp Val Gln Leu Arg Leu Asn Ser Ile 
            20                  25                  30          


Lys Lys Leu Ser Thr Ile Ala Leu Ala Leu Gly Val Glu Arg Thr Arg 
        35                  40                  45              


Ser Glu Leu Leu Pro Phe Leu Thr Asp Thr Ile Tyr Asp Glu Asp Glu 
    50                  55                  60                  


Val Leu Leu Ala Leu Ala Glu Gln Leu Gly Thr Phe Thr Thr Leu Val 
65                  70                  75                  80  


Gly Gly Pro Glu Tyr Val His Cys Leu Leu Pro Pro Leu Glu Ser Leu 
                85                  90                  95      


Ala Thr Val Glu Glu Thr Val Val Arg Asp Lys Ala Val Glu Ser Leu 
            100                 105                 110         


Arg Ala Ile Ser His Glu His Ser Pro Ser Asp Leu Glu Ala His Phe 
        115                 120                 125             


Val Pro Leu Val Lys Arg Leu Ala Gly Gly Asp Trp Phe Thr Ser Arg 
    130                 135                 140                 


Thr Ser Ala Cys Gly Leu Phe Ser Val Cys Tyr Pro Arg Val Ser Ser 
145                 150                 155                 160 


Ala Val Lys Ala Glu Leu Arg Gln Tyr Phe Arg Asn Leu Cys Ser Asp 
                165                 170                 175     


Asp Thr Pro Met Val Arg Arg Ala Ala Ala Ser Lys Leu Gly Glu Phe 
            180                 185                 190         


Ala Lys Val Leu Glu Leu Asp Asn Val Lys Ser Glu Ile Ile Pro Met 
        195                 200                 205             


Phe Ser Asn Leu Ala Ser Asp Glu Gln Asp Ser Val Arg Leu Leu Ala 
    210                 215                 220                 


Val Glu Ala Cys Val Asn Ile Ala Gln Leu Leu Pro Gln Glu Asp Leu 
225                 230                 235                 240 


Glu Ala Leu Val Met Pro Thr Leu Arg Gln Ala Ala Glu Asp Lys Ser 
                245                 250                 255     


Trp Arg Val Arg Tyr Met Val Ala Asp Lys Phe Thr Glu Leu Gln Lys 
            260                 265                 270         


Ala Val Gly Pro Glu Ile Thr Lys Thr Asp Leu Val Pro Ala Phe Gln 
        275                 280                 285             


Asn Leu Met Lys Asp Cys Glu Ala Glu Val Arg Ala Ala Ala Ser His 
    290                 295                 300                 


Lys Val Lys Glu Phe Cys Glu Asn Leu Ser Ala Asp Cys Arg Glu Asn 
305                 310                 315                 320 


Val Ile Met Ser Gln Ile Leu Pro Cys Ile Lys Glu Leu Val Ser Asp 
                325                 330                 335     


Ala Asn Gln His Val Lys Ser Ala Leu Ala Ser Val Ile Met Gly Leu 
            340                 345                 350         


Ser Pro Ile Leu Gly Lys Asp Asn Thr Ile Glu His Leu Leu Pro Leu 
        355                 360                 365             


Phe Leu Ala Gln Leu Lys Asp Glu Cys Pro Glu Val Arg Leu Asn Ile 
    370                 375                 380                 


Ile Ser Asn Leu Asp Cys Val Asn Glu Val Ile Gly Ile Arg Gln Leu 
385                 390                 395                 400 


Ser Gln Ser Leu Leu Pro Ala Ile Val Glu Leu Ala Glu Asp Ala Lys 
                405                 410                 415     


Trp Arg Val Arg Leu Ala Ile Ile Glu Tyr Met Pro Leu Leu Ala Gly 
            420                 425                 430         


Gln Leu Gly Val Glu Phe Phe Asp Glu Lys Leu Asn Ser Leu Cys Met 
        435                 440                 445             


Ala Trp Leu Val Asp His Val Tyr Ala Ile Arg Glu Ala Ala Thr Ser 
    450                 455                 460                 


Asn Leu Lys Lys Leu Val Glu Lys Phe Gly Lys Glu Trp Ala His Ala 
465                 470                 475                 480 


Thr Ile Ile Pro Lys Val Leu Ala Met Ser Gly Asp Pro Asn Tyr Leu 
                485                 490                 495     


His Arg Met Thr Thr Leu Phe Cys Ile Asn Val Leu Ser Glu Val Cys 
            500                 505                 510         


Gly Gln Asp Ile Thr Thr Lys His Met Leu Pro Thr Val Leu Arg Met 
        515                 520                 525             


Ala Gly Asp Pro Val Ala Asn Val Arg Phe Asn Val Ala Lys Ser Leu 
    530                 535                 540                 


Gln Lys Ile Gly Pro Ile Leu Asp Asn Ser Thr Leu Gln Ser Glu Val 
545                 550                 555                 560 


Lys Pro Ile Leu Glu Lys Leu Thr Gln Asp Gln Asp Val Asp Val Lys 
                565                 570                 575     


Tyr Phe Ala Gln Glu Ala Leu Thr Val Leu Ser Leu Ala 
            580                 585                 


<210>  120
<211>  466
<212>  PRT
<213>  Homo sapiens

<400>  120

Met Arg Leu Arg Thr Arg Lys Ala Ser Gln Gln Ser Asn Gln Ile Gln 
1               5                   10                  15      


Thr Gln Arg Thr Ala Arg Ala Lys Arg Lys Tyr Ser Glu Val Asp Asp 
            20                  25                  30          


Ser Leu Pro Ser Gly Gly Glu Lys Pro Ser Lys Asn Glu Thr Gly Leu 
        35                  40                  45              


Leu Ser Ser Ile Lys Lys Phe Ile Lys Gly Ser Thr Pro Lys Glu Glu 
    50                  55                  60                  


Arg Glu Asn Pro Ser Lys Arg Ser Arg Ile Glu Arg Asp Ile Asp Asn 
65                  70                  75                  80  


Asn Leu Ile Thr Ser Thr Pro Arg Ala Gly Glu Lys Pro Asn Lys Gln 
                85                  90                  95      


Ile Ser Arg Val Arg Arg Lys Ser Gln Val Asn Gly Glu Ala Gly Ser 
            100                 105                 110         


Tyr Glu Met Thr Asn Gln His Val Lys Gln Asn Gly Lys Leu Glu Asp 
        115                 120                 125             


Asn Pro Ser Ser Gly Ser Pro Pro Arg Thr Thr Leu Leu Gly Thr Ile 
    130                 135                 140                 


Phe Ser Pro Val Phe Asn Phe Phe Ser Pro Ala Asn Lys Asn Gly Thr 
145                 150                 155                 160 


Ser Gly Ser Asp Ser Pro Gly Gln Ala Val Glu Ala Glu Glu Ile Val 
                165                 170                 175     


Lys Gln Leu Asp Met Glu Gln Val Asp Glu Ile Thr Thr Ser Thr Thr 
            180                 185                 190         


Thr Ser Thr Asn Gly Ala Ala Tyr Ser Asn Gln Ala Val Gln Val Arg 
        195                 200                 205             


Pro Ser Leu Asn Asn Gly Leu Glu Glu Ala Glu Glu Thr Val Asn Arg 
    210                 215                 220                 


Asp Ile Pro Pro Leu Thr Ala Pro Val Thr Pro Asp Ser Gly Tyr Ser 
225                 230                 235                 240 


Ser Ala His Ala Glu Ala Thr Tyr Glu Glu Asp Trp Glu Val Phe Asp 
                245                 250                 255     


Pro Tyr Tyr Phe Ile Lys His Val Pro Pro Leu Thr Glu Glu Gln Leu 
            260                 265                 270         


Asn Arg Lys Pro Ala Leu Pro Leu Lys Thr Arg Ser Thr Pro Glu Phe 
        275                 280                 285             


Ser Leu Val Leu Asp Leu Asp Glu Thr Leu Val His Cys Ser Leu Asn 
    290                 295                 300                 


Glu Leu Glu Asp Ala Ala Leu Thr Phe Pro Val Leu Phe Gln Asp Val 
305                 310                 315                 320 


Ile Tyr Gln Val Tyr Val Arg Leu Arg Pro Phe Phe Arg Glu Phe Leu 
                325                 330                 335     


Glu Arg Met Ser Gln Met Tyr Glu Ile Ile Leu Phe Thr Ala Ser Lys 
            340                 345                 350         


Lys Val Tyr Ala Asp Lys Leu Leu Asn Ile Leu Asp Pro Lys Lys Gln 
        355                 360                 365             


Leu Val Arg His Arg Leu Phe Arg Glu His Cys Val Cys Val Gln Gly 
    370                 375                 380                 


Asn Tyr Ile Lys Asp Leu Asn Ile Leu Gly Arg Asp Leu Ser Lys Thr 
385                 390                 395                 400 


Ile Ile Ile Asp Asn Ser Pro Gln Ala Phe Ala Tyr Gln Leu Ser Asn 
                405                 410                 415     


Gly Ile Pro Ile Glu Ser Trp Phe Met Asp Lys Asn Asp Asn Glu Leu 
            420                 425                 430         


Leu Lys Leu Ile Pro Phe Leu Glu Lys Leu Val Glu Leu Asn Glu Asp 
        435                 440                 445             


Val Arg Pro His Ile Arg Asp Arg Phe Arg Leu His Asp Leu Leu Pro 
    450                 455                 460                 


Pro Asp 
465     


<210>  121
<211>  1500
<212>  PRT
<213>  Homo sapiens

<400>  121

Met Thr Arg Ile Leu Thr Ala Phe Lys Val Val Arg Thr Leu Lys Thr 
1               5                   10                  15      


Gly Phe Gly Phe Thr Asn Val Thr Ala His Gln Lys Trp Lys Phe Ser 
            20                  25                  30          


Arg Pro Gly Ile Arg Leu Leu Ser Val Lys Ala Gln Thr Ala His Ile 
        35                  40                  45              


Val Leu Glu Asp Gly Thr Lys Met Lys Gly Tyr Ser Phe Gly His Pro 
    50                  55                  60                  


Ser Ser Val Ala Gly Glu Val Val Phe Asn Thr Gly Leu Gly Gly Tyr 
65                  70                  75                  80  


Pro Glu Ala Ile Thr Asp Pro Ala Tyr Lys Gly Gln Ile Leu Thr Met 
                85                  90                  95      


Ala Asn Pro Ile Ile Gly Asn Gly Gly Ala Pro Asp Thr Thr Ala Leu 
            100                 105                 110         


Asp Glu Leu Gly Leu Ser Lys Tyr Leu Glu Ser Asn Gly Ile Lys Val 
        115                 120                 125             


Ser Gly Leu Leu Val Leu Asp Tyr Ser Lys Asp Tyr Asn His Trp Leu 
    130                 135                 140                 


Ala Thr Lys Ser Leu Gly Gln Trp Leu Gln Glu Glu Lys Val Pro Ala 
145                 150                 155                 160 


Ile Tyr Gly Val Asp Thr Arg Met Leu Thr Lys Ile Ile Arg Asp Lys 
                165                 170                 175     


Gly Thr Met Leu Gly Lys Ile Glu Phe Glu Gly Gln Pro Val Asp Phe 
            180                 185                 190         


Val Asp Pro Asn Lys Gln Asn Leu Ile Ala Glu Val Ser Thr Lys Asp 
        195                 200                 205             


Val Lys Val Tyr Gly Lys Gly Asn Pro Thr Lys Val Val Ala Val Asp 
    210                 215                 220                 


Cys Gly Ile Lys Asn Asn Val Ile Arg Leu Leu Val Lys Arg Gly Ala 
225                 230                 235                 240 


Glu Val His Leu Val Pro Trp Asn His Asp Phe Thr Lys Met Glu Tyr 
                245                 250                 255     


Asp Gly Ile Leu Ile Ala Gly Gly Pro Gly Asn Pro Ala Leu Ala Glu 
            260                 265                 270         


Pro Leu Ile Gln Asn Val Arg Lys Ile Leu Glu Ser Asp Arg Lys Glu 
        275                 280                 285             


Pro Leu Phe Gly Ile Ser Thr Gly Asn Leu Ile Thr Gly Leu Ala Ala 
    290                 295                 300                 


Gly Ala Lys Thr Tyr Lys Met Ser Met Ala Asn Arg Gly Gln Asn Gln 
305                 310                 315                 320 


Pro Val Leu Asn Ile Thr Asn Lys Gln Ala Phe Ile Thr Ala Gln Asn 
                325                 330                 335     


His Gly Tyr Ala Leu Asp Asn Thr Leu Pro Ala Gly Trp Lys Pro Leu 
            340                 345                 350         


Phe Val Asn Val Asn Asp Gln Thr Asn Glu Gly Ile Met His Glu Ser 
        355                 360                 365             


Lys Pro Phe Phe Ala Val Gln Phe His Pro Glu Val Thr Pro Gly Pro 
    370                 375                 380                 


Ile Asp Thr Glu Tyr Leu Phe Asp Ser Phe Phe Ser Leu Ile Lys Lys 
385                 390                 395                 400 


Gly Lys Ala Thr Thr Ile Thr Ser Val Leu Pro Lys Pro Ala Leu Val 
                405                 410                 415     


Ala Ser Arg Val Glu Val Ser Lys Val Leu Ile Leu Gly Ser Gly Gly 
            420                 425                 430         


Leu Ser Ile Gly Gln Ala Gly Glu Phe Asp Tyr Ser Gly Ser Gln Ala 
        435                 440                 445             


Val Lys Ala Met Lys Glu Glu Asn Val Lys Thr Val Leu Met Asn Pro 
    450                 455                 460                 


Asn Ile Ala Ser Val Gln Thr Asn Glu Val Gly Leu Lys Gln Ala Asp 
465                 470                 475                 480 


Thr Val Tyr Phe Leu Pro Ile Thr Pro Gln Phe Val Thr Glu Val Ile 
                485                 490                 495     


Lys Ala Glu Gln Pro Asp Gly Leu Ile Leu Gly Met Gly Gly Gln Thr 
            500                 505                 510         


Ala Leu Asn Cys Gly Val Glu Leu Phe Lys Arg Gly Val Leu Lys Glu 
        515                 520                 525             


Tyr Gly Val Lys Val Leu Gly Thr Ser Val Glu Ser Ile Met Ala Thr 
    530                 535                 540                 


Glu Asp Arg Gln Leu Phe Ser Asp Lys Leu Asn Glu Ile Asn Glu Lys 
545                 550                 555                 560 


Ile Ala Pro Ser Phe Ala Val Glu Ser Ile Glu Asp Ala Leu Lys Ala 
                565                 570                 575     


Ala Asp Thr Ile Gly Tyr Pro Val Met Ile Arg Ser Ala Tyr Ala Leu 
            580                 585                 590         


Gly Gly Leu Gly Ser Gly Ile Cys Pro Asn Arg Glu Thr Leu Met Asp 
        595                 600                 605             


Leu Ser Thr Lys Ala Phe Ala Met Thr Asn Gln Ile Leu Val Glu Lys 
    610                 615                 620                 


Ser Val Thr Gly Trp Lys Glu Ile Glu Tyr Glu Val Val Arg Asp Ala 
625                 630                 635                 640 


Asp Asp Asn Cys Val Thr Val Cys Asn Met Glu Asn Val Asp Ala Met 
                645                 650                 655     


Gly Val His Thr Gly Asp Ser Val Val Val Ala Pro Ala Gln Thr Leu 
            660                 665                 670         


Ser Asn Ala Glu Phe Gln Met Leu Arg Arg Thr Ser Ile Asn Val Val 
        675                 680                 685             


Arg His Leu Gly Ile Val Gly Glu Cys Asn Ile Gln Phe Ala Leu His 
    690                 695                 700                 


Pro Thr Ser Met Glu Tyr Cys Ile Ile Glu Val Asn Ala Arg Leu Ser 
705                 710                 715                 720 


Arg Ser Ser Ala Leu Ala Ser Lys Ala Thr Gly Tyr Pro Leu Ala Phe 
                725                 730                 735     


Ile Ala Ala Lys Ile Ala Leu Gly Ile Pro Leu Pro Glu Ile Lys Asn 
            740                 745                 750         


Val Val Ser Gly Lys Thr Ser Ala Cys Phe Glu Pro Ser Leu Asp Tyr 
        755                 760                 765             


Met Val Thr Lys Ile Pro Arg Trp Asp Leu Asp Arg Phe His Gly Thr 
    770                 775                 780                 


Ser Ser Arg Ile Gly Ser Ser Met Lys Ser Val Gly Glu Val Met Ala 
785                 790                 795                 800 


Ile Gly Arg Thr Phe Glu Glu Ser Phe Gln Lys Ala Leu Arg Met Cys 
                805                 810                 815     


His Pro Ser Ile Glu Gly Phe Thr Pro Arg Leu Pro Met Asn Lys Glu 
            820                 825                 830         


Trp Pro Ser Asn Leu Asp Leu Arg Lys Glu Leu Ser Glu Pro Ser Ser 
        835                 840                 845             


Thr Arg Ile Tyr Ala Ile Ala Lys Ala Ile Asp Asp Asn Met Ser Leu 
    850                 855                 860                 


Asp Glu Ile Glu Lys Leu Thr Tyr Ile Asp Lys Trp Phe Leu Tyr Lys 
865                 870                 875                 880 


Met Arg Asp Ile Leu Asn Met Glu Lys Thr Leu Lys Gly Leu Asn Ser 
                885                 890                 895     


Glu Ser Met Thr Glu Glu Thr Leu Lys Arg Ala Lys Glu Ile Gly Phe 
            900                 905                 910         


Ser Asp Lys Gln Ile Ser Lys Cys Leu Gly Leu Thr Glu Ala Gln Thr 
        915                 920                 925             


Arg Glu Leu Arg Leu Lys Lys Asn Ile His Pro Trp Val Lys Gln Ile 
    930                 935                 940                 


Asp Thr Leu Ala Ala Glu Tyr Pro Ser Val Thr Asn Tyr Leu Tyr Val 
945                 950                 955                 960 


Thr Tyr Asn Gly Gln Glu His Asp Val Asn Phe Asp Asp His Gly Met 
                965                 970                 975     


Met Val Leu Gly Cys Gly Pro Tyr His Ile Gly Ser Ser Val Glu Phe 
            980                 985                 990         


Asp Trp Cys Ala Val Ser Ser Ile  Arg Thr Leu Arg Gln  Leu Gly Lys 
        995                 1000                 1005             


Lys Thr  Val Val Val Asn Cys  Asn Pro Glu Thr Val  Ser Thr Asp 
    1010                 1015                 1020             


Phe Asp  Glu Cys Asp Lys Leu  Tyr Phe Glu Glu Leu  Ser Leu Glu 
    1025                 1030                 1035             


Arg Ile  Leu Asp Ile Tyr His  Gln Glu Ala Cys Gly  Gly Cys Ile 
    1040                 1045                 1050             


Ile Ser  Val Gly Gly Gln Ile  Pro Asn Asn Leu Ala  Val Pro Leu 
    1055                 1060                 1065             


Tyr Lys  Asn Gly Val Lys Ile  Met Gly Thr Ser Pro  Leu Gln Ile 
    1070                 1075                 1080             


Asp Arg  Ala Glu Asp Arg Ser  Ile Phe Ser Ala Val  Leu Asp Glu 
    1085                 1090                 1095             


Leu Lys  Val Ala Gln Ala Pro  Trp Lys Ala Val Asn  Thr Leu Asn 
    1100                 1105                 1110             


Glu Ala  Leu Glu Phe Ala Lys  Ser Val Asp Tyr Pro  Cys Leu Leu 
    1115                 1120                 1125             


Arg Pro  Ser Tyr Val Leu Ser  Gly Ser Ala Met Asn  Val Val Phe 
    1130                 1135                 1140             


Ser Glu  Asp Glu Met Lys Lys  Phe Leu Glu Glu Ala  Thr Arg Val 
    1145                 1150                 1155             


Ser Gln  Glu His Pro Val Val  Leu Thr Lys Phe Val  Glu Gly Ala 
    1160                 1165                 1170             


Arg Glu  Val Glu Met Asp Ala  Val Gly Lys Asp Gly  Arg Val Ile 
    1175                 1180                 1185             


Ser His  Ala Ile Ser Glu His  Val Glu Asp Ala Gly  Val His Ser 
    1190                 1195                 1200             


Gly Asp  Ala Thr Leu Met Leu  Pro Thr Gln Thr Ile  Ser Gln Gly 
    1205                 1210                 1215             


Ala Ile  Glu Lys Val Lys Asp  Ala Thr Arg Lys Ile  Ala Lys Ala 
    1220                 1225                 1230             


Phe Ala  Ile Ser Gly Pro Phe  Asn Val Gln Phe Leu  Val Lys Gly 
    1235                 1240                 1245             


Asn Asp  Val Leu Val Ile Glu  Cys Asn Leu Arg Ala  Ser Arg Ser 
    1250                 1255                 1260             


Phe Pro  Phe Val Ser Lys Thr  Leu Gly Val Asp Phe  Ile Asp Val 
    1265                 1270                 1275             


Ala Thr  Lys Val Met Ile Gly  Glu Asn Val Asp Glu  Lys His Leu 
    1280                 1285                 1290             


Pro Thr  Leu Asp His Pro Ile  Ile Pro Ala Asp Tyr  Val Ala Ile 
    1295                 1300                 1305             


Lys Ala  Pro Met Phe Ser Trp  Pro Arg Leu Arg Asp  Ala Asp Pro 
    1310                 1315                 1320             


Ile Leu  Arg Cys Glu Met Ala  Ser Thr Gly Glu Val  Ala Cys Phe 
    1325                 1330                 1335             


Gly Glu  Gly Ile His Thr Ala  Phe Leu Lys Ala Met  Leu Ser Thr 
    1340                 1345                 1350             


Gly Phe  Lys Ile Pro Gln Lys  Gly Ile Leu Ile Gly  Ile Gln Gln 
    1355                 1360                 1365             


Ser Phe  Arg Pro Arg Phe Leu  Gly Val Ala Glu Gln  Leu His Asn 
    1370                 1375                 1380             


Glu Gly  Phe Lys Leu Phe Ala  Thr Glu Ala Thr Ser  Asp Trp Leu 
    1385                 1390                 1395             


Asn Ala  Asn Asn Val Pro Ala  Thr Pro Val Ala Trp  Pro Ser Gln 
    1400                 1405                 1410             


Glu Gly  Gln Asn Pro Ser Leu  Ser Ser Ile Arg Lys  Leu Ile Arg 
    1415                 1420                 1425             


Asp Gly  Ser Ile Asp Leu Val  Ile Asn Leu Pro Asn  Asn Asn Thr 
    1430                 1435                 1440             


Lys Phe  Val His Asp Asn Tyr  Val Ile Arg Arg Thr  Ala Val Asp 
    1445                 1450                 1455             


Ser Gly  Ile Pro Leu Leu Thr  Asn Phe Gln Val Thr  Lys Leu Phe 
    1460                 1465                 1470             


Ala Glu  Ala Val Gln Lys Ser  Arg Lys Val Asp Ser  Lys Ser Leu 
    1475                 1480                 1485             


Phe His  Tyr Arg Gln Tyr Ser  Ala Gly Lys Ala Ala  
    1490                 1495                 1500 


<210>  122
<211>  654
<212>  PRT
<213>  Homo sapiens

<400>  122

Met Lys Leu Ser Leu Val Ala Ala Met Leu Leu Leu Leu Ser Ala Ala 
1               5                   10                  15      


Arg Ala Glu Glu Glu Asp Lys Lys Glu Asp Val Gly Thr Val Val Gly 
            20                  25                  30          


Ile Asp Leu Gly Thr Thr Tyr Ser Cys Val Gly Val Phe Lys Asn Gly 
        35                  40                  45              


Arg Val Glu Ile Ile Ala Asn Asp Gln Gly Asn Arg Ile Thr Pro Pro 
    50                  55                  60                  


Tyr Val Ala Phe Thr Pro Glu Gly Glu Arg Leu Ile Gly Asp Ala Ala 
65                  70                  75                  80  


Lys Asn Gln Leu Thr Ser Asn Pro Glu Asn Thr Val Phe Asp Ala Lys 
                85                  90                  95      


Arg Leu Ile Gly Arg Thr Trp Asn Asp Pro Ser Val Gln Gln Asp Ile 
            100                 105                 110         


Lys Phe Leu Pro Phe Lys Val Val Glu Lys Lys Thr Lys Pro Tyr Ile 
        115                 120                 125             


Gln Val Asp Ile Gly Gly Gly Gln Thr Lys Thr Phe Ala Pro Glu Glu 
    130                 135                 140                 


Ile Ser Ala Met Val Leu Thr Lys Met Lys Glu Thr Ala Glu Ala Tyr 
145                 150                 155                 160 


Leu Gly Lys Lys Val Thr His Ala Val Val Thr Val Pro Ala Tyr Phe 
                165                 170                 175     


Asn Asp Ala Gln Arg Gln Ala Thr Lys Asp Ala Gly Thr Ile Ala Gly 
            180                 185                 190         


Leu Asn Val Met Arg Ile Ile Asn Glu Pro Thr Ala Ala Ala Ile Ala 
        195                 200                 205             


Tyr Gly Leu Asp Lys Arg Glu Gly Glu Lys Asn Ile Leu Val Phe Asp 
    210                 215                 220                 


Leu Gly Gly Gly Thr Phe Asp Val Ser Leu Leu Thr Ile Asp Asn Gly 
225                 230                 235                 240 


Val Phe Glu Val Val Ala Thr Asn Gly Asp Thr His Leu Gly Gly Glu 
                245                 250                 255     


Asp Phe Asp Gln Arg Val Met Glu His Phe Ile Lys Leu Tyr Lys Lys 
            260                 265                 270         


Lys Thr Gly Lys Asp Val Arg Lys Asp Asn Arg Ala Val Gln Lys Leu 
        275                 280                 285             


Arg Arg Glu Val Glu Lys Ala Lys Arg Ala Leu Ser Ser Gln His Gln 
    290                 295                 300                 


Ala Arg Ile Glu Ile Glu Ser Phe Tyr Glu Gly Glu Asp Phe Ser Glu 
305                 310                 315                 320 


Thr Leu Thr Arg Ala Lys Phe Glu Glu Leu Asn Met Asp Leu Phe Arg 
                325                 330                 335     


Ser Thr Met Lys Pro Val Gln Lys Val Leu Glu Asp Ser Asp Leu Lys 
            340                 345                 350         


Lys Ser Asp Ile Asp Glu Ile Val Leu Val Gly Gly Ser Thr Arg Ile 
        355                 360                 365             


Pro Lys Ile Gln Gln Leu Val Lys Glu Phe Phe Asn Gly Lys Glu Pro 
    370                 375                 380                 


Ser Arg Gly Ile Asn Pro Asp Glu Ala Val Ala Tyr Gly Ala Ala Val 
385                 390                 395                 400 


Gln Ala Gly Val Leu Ser Gly Asp Gln Asp Thr Gly Asp Leu Ala Leu 
                405                 410                 415     


Leu Asp Val Cys Pro Leu Thr Leu Gly Ile Glu Thr Val Gly Gly Val 
            420                 425                 430         


Met Thr Lys Leu Ile Pro Arg Asn Thr Val Val Pro Thr Lys Lys Ser 
        435                 440                 445             


Gln Ile Phe Ser Thr Ala Ser Asp Asn Gln Pro Thr Val Thr Ile Lys 
    450                 455                 460                 


Val Tyr Glu Gly Glu Arg Pro Leu Thr Lys Asp Asn His Leu Leu Gly 
465                 470                 475                 480 


Thr Phe Asp Leu Thr Gly Ile Pro Pro Ala Pro Arg Gly Val Pro Gln 
                485                 490                 495     


Ile Glu Val Thr Phe Glu Ile Asp Val Asn Gly Ile Leu Arg Val Thr 
            500                 505                 510         


Ala Glu Asp Lys Gly Thr Gly Asn Lys Asn Lys Ile Thr Ile Thr Asn 
        515                 520                 525             


Asp Gln Asn Arg Leu Thr Pro Glu Glu Ile Glu Arg Met Val Asn Asp 
    530                 535                 540                 


Ala Glu Lys Phe Ala Glu Glu Asp Lys Lys Leu Lys Glu Arg Ile Asp 
545                 550                 555                 560 


Thr Arg Asn Glu Leu Glu Ser Tyr Ala Tyr Ser Leu Lys Asn Gln Ile 
                565                 570                 575     


Gly Asp Lys Glu Lys Leu Gly Gly Lys Leu Ser Ser Glu Asp Lys Glu 
            580                 585                 590         


Thr Met Glu Lys Ala Val Glu Glu Lys Ile Glu Trp Leu Glu Ser His 
        595                 600                 605             


Gln Asp Ala Asp Ile Glu Asp Phe Lys Ala Lys Lys Lys Glu Leu Glu 
    610                 615                 620                 


Glu Ile Val Gln Pro Ile Ile Ser Lys Leu Tyr Gly Ser Ala Gly Pro 
625                 630                 635                 640 


Pro Pro Thr Gly Glu Glu Asp Thr Ala Glu Lys Asp Glu Leu 
                645                 650                 


<210>  123
<211>  277
<212>  PRT
<213>  Homo sapiens

<400>  123

Met Ser Asp Gln Gln Leu Asp Cys Ala Leu Asp Leu Met Arg Arg Leu 
1               5                   10                  15      


Pro Pro Gln Gln Ile Glu Lys Asn Leu Ser Asp Leu Ile Asp Leu Val 
            20                  25                  30          


Pro Ser Leu Cys Glu Asp Leu Leu Ser Ser Val Asp Gln Pro Leu Lys 
        35                  40                  45              


Ile Ala Arg Asp Lys Val Val Gly Lys Asp Tyr Leu Leu Cys Asp Tyr 
    50                  55                  60                  


Asn Arg Asp Gly Asp Ser Tyr Arg Ser Pro Trp Ser Asn Lys Tyr Asp 
65                  70                  75                  80  


Pro Pro Leu Glu Asp Gly Ala Met Pro Ser Ala Arg Leu Arg Lys Leu 
                85                  90                  95      


Glu Val Glu Ala Asn Asn Ala Phe Asp Gln Tyr Arg Asp Leu Tyr Phe 
            100                 105                 110         


Glu Gly Gly Val Ser Ser Val Tyr Leu Trp Asp Leu Asp His Gly Phe 
        115                 120                 125             


Ala Gly Val Ile Leu Ile Lys Lys Ala Gly Asp Gly Ser Lys Lys Ile 
    130                 135                 140                 


Lys Gly Cys Trp Asp Ser Ile His Val Val Glu Val Gln Glu Lys Ser 
145                 150                 155                 160 


Ser Gly Arg Thr Ala His Tyr Lys Leu Thr Ser Thr Val Met Leu Trp 
                165                 170                 175     


Leu Gln Thr Asn Lys Ser Gly Ser Gly Thr Met Asn Leu Gly Gly Ser 
            180                 185                 190         


Leu Thr Arg Gln Met Glu Lys Asp Glu Thr Val Ser Asp Cys Ser Pro 
        195                 200                 205             


His Ile Ala Asn Ile Gly Arg Leu Val Glu Asp Met Glu Asn Lys Ile 
    210                 215                 220                 


Arg Ser Thr Leu Asn Glu Ile Tyr Phe Gly Lys Thr Lys Asp Ile Val 
225                 230                 235                 240 


Asn Gly Leu Arg Ser Ile Asp Ala Ile Pro Asp Asn Gln Lys Phe Lys 
                245                 250                 255     


Gln Leu Gln Arg Glu Leu Ser Gln Val Leu Thr Gln Arg Gln Ile Tyr 
            260                 265                 270         


Ile Gln Pro Asp Asn 
        275         


<210>  124
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  124

Met Ala Lys Gly Leu Leu Val Thr Tyr Ala Leu Trp Ala Val Gly Gly 
1               5                   10                  15      


Pro Ala Gly Leu His His Leu Tyr Leu Gly Arg Asp Ser His Ala Leu 
            20                  25                  30          


Leu Trp Met Leu Thr Leu Gly Gly Gly Gly Leu Gly Trp Leu Trp Glu 
        35                  40                  45              


Phe Trp Lys Leu Pro Ser Phe Val Ala Gln Ala Asn Arg Ala Gln Gly 
    50                  55                  60                  


Gln Arg Gln Ser Pro Arg Gly Val Thr Pro Pro Leu Ser Pro Ile Arg 
65                  70                  75                  80  


Phe Ala Ala Gln Val Ile Val Gly Ile Tyr Phe Gly Leu Val Ala Leu 
                85                  90                  95      


Ile Ser Leu Ser Ser Met Val Asn Phe Tyr Ile Val Ala Leu Pro Leu 
            100                 105                 110         


Ala Val Gly Leu Gly Val Leu Leu Val Ala Ala Val Gly Asn Gln Thr 
        115                 120                 125             


Ser Asp Phe Lys Asn Thr Leu Gly Ala Ala Phe Leu Thr Ser Pro Ile 
    130                 135                 140                 


Phe Tyr Gly Arg Pro Ile Ala Ile Leu Pro Ile Ser Val Ala Ala Ser 
145                 150                 155                 160 


Ile Thr Ala Gln Lys Arg Arg Arg Tyr Lys Ala Leu Val Ala Ser Glu 
                165                 170                 175     


Pro Leu Ser Val Arg Leu Tyr Arg Leu Gly Leu Ala Tyr Leu Ala Phe 
            180                 185                 190         


Thr Gly Pro Leu Ala Tyr Ser Ala Leu Cys Asn Thr Ala Ala Thr Leu 
        195                 200                 205             


Ser Tyr Val Ala Glu Thr Phe Gly Ser Phe Leu Asn Trp Phe Ser Phe 
    210                 215                 220                 


Phe Pro Leu Leu Gly Arg Leu Met Glu Phe Val Leu Leu Leu Pro Tyr 
225                 230                 235                 240 


Arg Ile Trp Arg Leu Leu Met Gly Glu Thr Gly Phe Asn Ser Ser Tyr 
                245                 250                 255     


Phe Gln Glu Trp Ala Lys Leu Tyr Glu Phe Val His Ser Phe Gln Asp 
            260                 265                 270         


Glu Lys Arg Gln Leu Ala Tyr Gln Val Leu Gly Leu Ser Glu Gly Ala 
        275                 280                 285             


Thr Asn Glu Glu Ile His Arg Ser Tyr Arg Glu Leu Val Lys Val Trp 
    290                 295                 300                 


His Pro Asp His Asn Leu Asp Gln Thr Glu Glu Ala Gln Arg His Phe 
305                 310                 315                 320 


Leu Glu Ile Gln Ala Ala Tyr Glu Val Leu Ser Gln Pro Arg Lys Pro 
                325                 330                 335     


Arg Gly Ser Arg Arg 
            340     


<210>  125
<211>  409
<212>  PRT
<213>  Homo sapiens

<400>  125

Met Gln Arg Arg Arg Arg Pro Pro Pro Pro Thr Ser Arg Leu Pro Glu 
1               5                   10                  15      


Gly Cys Gly Gly Gly Gly Gly Gly Ser Glu Glu Val Glu Val Gln Phe 
            20                  25                  30          


Ser Ala Gly Arg Trp Gly Ser Ala Ala Ala Val Ser Ala Ala Ala Ala 
        35                  40                  45              


Ala Ala Thr Arg Ser Thr Glu Glu Glu Glu Glu Arg Leu Glu Arg Glu 
    50                  55                  60                  


His Phe Trp Lys Ile Ile Asn Ala Phe Arg Tyr Tyr Gly Thr Ser Met 
65                  70                  75                  80  


His Glu Arg Val Asn Arg Thr Glu Arg Gln Phe Arg Ser Leu Pro Ala 
                85                  90                  95      


Asn Gln Gln Lys Leu Leu Pro Gln Phe Leu Leu His Leu Asp Lys Ile 
            100                 105                 110         


Arg Lys Cys Ile Asp His Asn Gln Glu Ile Leu Leu Thr Ile Val Asn 
        115                 120                 125             


Asp Cys Ile His Met Phe Glu Asn Lys Glu Tyr Gly Glu Asp Gly Asn 
    130                 135                 140                 


Gly Lys Ile Met Pro Ala Ser Thr Phe Asp Met Asp Lys Leu Lys Ser 
145                 150                 155                 160 


Thr Leu Lys Gln Phe Val Arg Asp Trp Ser Glu Thr Gly Lys Ala Glu 
                165                 170                 175     


Arg Asp Ala Cys Tyr Gln Pro Ile Ile Lys Glu Ile Leu Lys Asn Phe 
            180                 185                 190         


Pro Lys Glu Arg Trp Asp Pro Ser Lys Val Asn Ile Leu Val Pro Gly 
        195                 200                 205             


Ala Gly Leu Gly Arg Leu Ala Trp Glu Ile Ala Met Leu Gly Tyr Ala 
    210                 215                 220                 


Cys Gln Gly Asn Glu Trp Ser Phe Phe Met Leu Phe Ser Ser Asn Phe 
225                 230                 235                 240 


Val Leu Asn Arg Cys Ser Glu Ile Asn Lys Tyr Lys Leu Tyr Pro Trp 
                245                 250                 255     


Ile His Gln Phe Ser Asn Asn Arg Arg Ser Ala Asp Gln Ile Arg Pro 
            260                 265                 270         


Ile Phe Phe Pro Asp Val Asp Pro His Ser Leu Pro Pro Gly Ser Asn 
        275                 280                 285             


Phe Ser Met Thr Ala Gly Asp Phe Gln Glu Ile Tyr Ser Glu Cys Asn 
    290                 295                 300                 


Thr Trp Asp Cys Ile Ala Thr Cys Phe Phe Ile Asp Thr Ala His Asn 
305                 310                 315                 320 


Val Ile Asp Tyr Ile Asp Thr Ile Trp Lys Ile Leu Lys Pro Gly Gly 
                325                 330                 335     


Ile Trp Ile Asn Leu Gly Pro Leu Leu Tyr His Phe Glu Asn Leu Ala 
            340                 345                 350         


Asn Glu Leu Ser Ile Glu Leu Ser Tyr Glu Asp Ile Lys Asn Val Val 
        355                 360                 365             


Leu Gln Tyr Gly Phe Lys Val Glu Val Glu Lys Glu Ser Val Leu Ser 
    370                 375                 380                 


Thr Tyr Thr Val Asn Asp Leu Ser Met Met Lys Tyr Tyr Tyr Glu Cys 
385                 390                 395                 400 


Val Leu Phe Val Val Arg Lys Pro Gln 
                405                 


<210>  126
<211>  4646
<212>  PRT
<213>  Homo sapiens

<400>  126

Met Ser Glu Pro Gly Gly Gly Gly Gly Glu Asp Gly Ser Ala Gly Leu 
1               5                   10                  15      


Glu Val Ser Ala Val Gln Asn Val Ala Asp Val Ser Val Leu Gln Lys 
            20                  25                  30          


His Leu Arg Lys Leu Val Pro Leu Leu Leu Glu Asp Gly Gly Glu Ala 
        35                  40                  45              


Pro Ala Ala Leu Glu Ala Ala Leu Glu Glu Lys Ser Ala Leu Glu Gln 
    50                  55                  60                  


Met Arg Lys Phe Leu Ser Asp Pro Gln Val His Thr Val Leu Val Glu 
65                  70                  75                  80  


Arg Ser Thr Leu Lys Glu Asp Val Gly Asp Glu Gly Glu Glu Glu Lys 
                85                  90                  95      


Glu Phe Ile Ser Tyr Asn Ile Asn Ile Asp Ile His Tyr Gly Val Lys 
            100                 105                 110         


Ser Asn Ser Leu Ala Phe Ile Lys Arg Thr Pro Val Ile Asp Ala Asp 
        115                 120                 125             


Lys Pro Val Ser Ser Gln Leu Arg Val Leu Thr Leu Ser Glu Asp Ser 
    130                 135                 140                 


Pro Tyr Glu Thr Leu His Ser Phe Ile Ser Asn Ala Val Ala Pro Phe 
145                 150                 155                 160 


Phe Lys Ser Tyr Ile Arg Glu Ser Gly Lys Ala Asp Arg Asp Gly Asp 
                165                 170                 175     


Lys Met Ala Pro Ser Val Glu Lys Lys Ile Ala Glu Leu Glu Met Gly 
            180                 185                 190         


Leu Leu His Leu Gln Gln Asn Ile Glu Ile Pro Glu Ile Ser Leu Pro 
        195                 200                 205             


Ile His Pro Met Ile Thr Asn Val Ala Lys Gln Cys Tyr Glu Arg Gly 
    210                 215                 220                 


Glu Lys Pro Lys Val Thr Asp Phe Gly Asp Lys Val Glu Asp Pro Thr 
225                 230                 235                 240 


Phe Leu Asn Gln Leu Gln Ser Gly Val Asn Arg Trp Ile Arg Glu Ile 
                245                 250                 255     


Gln Lys Val Thr Lys Leu Asp Arg Asp Pro Ala Ser Gly Thr Ala Leu 
            260                 265                 270         


Gln Glu Ile Ser Phe Trp Leu Asn Leu Glu Arg Ala Leu Tyr Arg Ile 
        275                 280                 285             


Gln Glu Lys Arg Glu Ser Pro Glu Val Leu Leu Thr Leu Asp Ile Leu 
    290                 295                 300                 


Lys His Gly Lys Arg Phe His Ala Thr Val Ser Phe Asp Thr Asp Thr 
305                 310                 315                 320 


Gly Leu Lys Gln Ala Leu Glu Thr Val Asn Asp Tyr Asn Pro Leu Met 
                325                 330                 335     


Lys Asp Phe Pro Leu Asn Asp Leu Leu Ser Ala Thr Glu Leu Asp Lys 
            340                 345                 350         


Ile Arg Gln Ala Leu Val Ala Ile Phe Thr His Leu Arg Lys Ile Arg 
        355                 360                 365             


Asn Thr Lys Tyr Pro Ile Gln Arg Ala Leu Arg Leu Val Glu Ala Ile 
    370                 375                 380                 


Ser Arg Asp Leu Ser Ser Gln Leu Leu Lys Val Leu Gly Thr Arg Lys 
385                 390                 395                 400 


Leu Met His Val Ala Tyr Glu Glu Phe Glu Lys Val Met Val Ala Cys 
                405                 410                 415     


Phe Glu Val Phe Gln Thr Trp Asp Asp Glu Tyr Glu Lys Leu Gln Val 
            420                 425                 430         


Leu Leu Arg Asp Ile Val Lys Arg Lys Arg Glu Glu Asn Leu Lys Met 
        435                 440                 445             


Val Trp Arg Ile Asn Pro Ala His Arg Lys Leu Gln Ala Arg Leu Asp 
    450                 455                 460                 


Gln Met Arg Lys Phe Arg Arg Gln His Glu Gln Leu Arg Ala Val Ile 
465                 470                 475                 480 


Val Arg Val Leu Arg Pro Gln Val Thr Ala Val Ala Gln Gln Asn Gln 
                485                 490                 495     


Gly Glu Val Pro Glu Pro Gln Asp Met Lys Val Ala Glu Val Leu Phe 
            500                 505                 510         


Asp Ala Ala Asp Ala Asn Ala Ile Glu Glu Val Asn Leu Ala Tyr Glu 
        515                 520                 525             


Asn Val Lys Glu Val Asp Gly Leu Asp Val Ser Lys Glu Gly Thr Glu 
    530                 535                 540                 


Ala Trp Glu Ala Ala Met Lys Arg Tyr Asp Glu Arg Ile Asp Arg Val 
545                 550                 555                 560 


Glu Thr Arg Ile Thr Ala Arg Leu Arg Asp Gln Leu Gly Thr Ala Lys 
                565                 570                 575     


Asn Ala Asn Glu Met Phe Arg Ile Phe Ser Arg Phe Asn Ala Leu Phe 
            580                 585                 590         


Val Arg Pro His Ile Arg Gly Ala Ile Arg Glu Tyr Gln Thr Gln Leu 
        595                 600                 605             


Ile Gln Arg Val Lys Asp Asp Ile Glu Ser Leu His Asp Lys Phe Lys 
    610                 615                 620                 


Val Gln Tyr Pro Gln Ser Gln Ala Cys Lys Met Ser His Val Arg Asp 
625                 630                 635                 640 


Leu Pro Pro Val Ser Gly Ser Ile Ile Trp Ala Lys Gln Ile Asp Arg 
                645                 650                 655     


Gln Leu Thr Ala Tyr Met Lys Arg Val Glu Asp Val Leu Gly Lys Gly 
            660                 665                 670         


Trp Glu Asn His Val Glu Gly Gln Lys Leu Lys Gln Asp Gly Asp Ser 
        675                 680                 685             


Phe Arg Met Lys Leu Asn Thr Gln Glu Ile Phe Asp Asp Trp Ala Arg 
    690                 695                 700                 


Lys Val Gln Gln Arg Asn Leu Gly Val Ser Gly Arg Ile Phe Thr Ile 
705                 710                 715                 720 


Glu Ser Thr Arg Val Arg Gly Arg Thr Gly Asn Val Leu Lys Leu Lys 
                725                 730                 735     


Val Asn Phe Leu Pro Glu Ile Ile Thr Leu Ser Lys Glu Val Arg Asn 
            740                 745                 750         


Leu Lys Trp Leu Gly Phe Arg Val Pro Leu Ala Ile Val Asn Lys Ala 
        755                 760                 765             


His Gln Ala Asn Gln Leu Tyr Pro Phe Ala Ile Ser Leu Ile Glu Ser 
    770                 775                 780                 


Val Arg Thr Tyr Glu Arg Thr Cys Glu Lys Val Glu Glu Arg Asn Thr 
785                 790                 795                 800 


Ile Ser Leu Leu Val Ala Gly Leu Lys Lys Glu Val Gln Ala Leu Ile 
                805                 810                 815     


Ala Glu Gly Ile Ala Leu Val Trp Glu Ser Tyr Lys Leu Asp Pro Tyr 
            820                 825                 830         


Val Gln Arg Leu Ala Glu Thr Val Phe Asn Phe Gln Glu Lys Val Asp 
        835                 840                 845             


Asp Leu Leu Ile Ile Glu Glu Lys Ile Asp Leu Glu Val Arg Ser Leu 
    850                 855                 860                 


Glu Thr Cys Met Tyr Asp His Lys Thr Phe Ser Glu Ile Leu Asn Arg 
865                 870                 875                 880 


Val Gln Lys Ala Val Asp Asp Leu Asn Leu His Ser Tyr Ser Asn Leu 
                885                 890                 895     


Pro Ile Trp Val Asn Lys Leu Asp Met Glu Ile Glu Arg Ile Leu Gly 
            900                 905                 910         


Val Arg Leu Gln Ala Gly Leu Arg Ala Trp Thr Gln Val Leu Leu Gly 
        915                 920                 925             


Gln Ala Glu Asp Lys Ala Glu Val Asp Met Asp Thr Asp Ala Pro Gln 
    930                 935                 940                 


Val Ser His Lys Pro Gly Gly Glu Pro Lys Ile Lys Asn Val Val His 
945                 950                 955                 960 


Glu Leu Arg Ile Thr Asn Gln Val Ile Tyr Leu Asn Pro Pro Ile Glu 
                965                 970                 975     


Glu Cys Arg Tyr Lys Leu Tyr Gln Glu Met Phe Ala Trp Lys Met Val 
            980                 985                 990         


Val Leu Ser Leu Pro Arg Ile Gln  Ser Gln Arg Tyr Gln  Val Gly Val 
        995                 1000                 1005             


His Tyr  Glu Leu Thr Glu Glu  Glu Lys Phe Tyr Arg  Asn Ala Leu 
    1010                 1015                 1020             


Thr Arg  Met Pro Asp Gly Pro  Val Ala Leu Glu Glu  Ser Tyr Ser 
    1025                 1030                 1035             


Ala Val  Met Gly Ile Val Ser  Glu Val Glu Gln Tyr  Val Lys Val 
    1040                 1045                 1050             


Trp Leu  Gln Tyr Gln Cys Leu  Trp Asp Met Gln Ala  Glu Asn Ile 
    1055                 1060                 1065             


Tyr Asn  Arg Leu Gly Glu Asp  Leu Asn Lys Trp Gln  Ala Leu Leu 
    1070                 1075                 1080             


Val Gln  Ile Arg Lys Ala Arg  Gly Thr Phe Asp Asn  Ala Glu Thr 
    1085                 1090                 1095             


Lys Lys  Glu Phe Gly Pro Val  Val Ile Asp Tyr Gly  Lys Val Gln 
    1100                 1105                 1110             


Ser Lys  Val Asn Leu Lys Tyr  Asp Ser Trp His Lys  Glu Val Leu 
    1115                 1120                 1125             


Ser Lys  Phe Gly Gln Met Leu  Gly Ser Asn Met Thr  Glu Phe His 
    1130                 1135                 1140             


Ser Gln  Ile Ser Lys Ser Arg  Gln Glu Leu Glu Gln  His Ser Val 
    1145                 1150                 1155             


Asp Thr  Ala Ser Thr Ser Asp  Ala Val Thr Phe Ile  Thr Tyr Val 
    1160                 1165                 1170             


Gln Ser  Leu Lys Arg Lys Ile  Lys Gln Phe Glu Lys  Gln Val Glu 
    1175                 1180                 1185             


Leu Tyr  Arg Asn Gly Gln Arg  Leu Leu Glu Lys Gln  Arg Phe Gln 
    1190                 1195                 1200             


Phe Pro  Pro Ser Trp Leu Tyr  Ile Asp Asn Ile Glu  Gly Glu Trp 
    1205                 1210                 1215             


Gly Ala  Phe Asn Asp Ile Met  Arg Arg Lys Asp Ser  Ala Ile Gln 
    1220                 1225                 1230             


Gln Gln  Val Ala Asn Leu Gln  Met Lys Ile Val Gln  Glu Asp Arg 
    1235                 1240                 1245             


Ala Val  Glu Ser Arg Thr Thr  Asp Leu Leu Thr Asp  Trp Glu Lys 
    1250                 1255                 1260             


Thr Lys  Pro Val Thr Gly Asn  Leu Arg Pro Glu Glu  Ala Leu Gln 
    1265                 1270                 1275             


Ala Leu  Thr Ile Tyr Glu Gly  Lys Phe Gly Arg Leu  Lys Asp Asp 
    1280                 1285                 1290             


Arg Glu  Lys Cys Ala Lys Ala  Lys Glu Ala Leu Glu  Leu Thr Asp 
    1295                 1300                 1305             


Thr Gly  Leu Leu Ser Gly Ser  Glu Glu Arg Val Gln  Val Ala Leu 
    1310                 1315                 1320             


Glu Glu  Leu Gln Asp Leu Lys  Gly Val Trp Ser Glu  Leu Ser Lys 
    1325                 1330                 1335             


Val Trp  Glu Gln Ile Asp Gln  Met Lys Glu Gln Pro  Trp Val Ser 
    1340                 1345                 1350             


Val Gln  Pro Arg Lys Leu Arg  Gln Asn Leu Asp Ala  Leu Leu Asn 
    1355                 1360                 1365             


Gln Leu  Lys Ser Phe Pro Ala  Arg Leu Arg Gln Tyr  Ala Ser Tyr 
    1370                 1375                 1380             


Glu Phe  Val Gln Arg Leu Leu  Lys Gly Tyr Met Lys  Ile Asn Met 
    1385                 1390                 1395             


Leu Val  Ile Glu Leu Lys Ser  Glu Ala Leu Lys Asp  Arg His Trp 
    1400                 1405                 1410             


Lys Gln  Leu Met Lys Arg Leu  His Val Asn Trp Val  Val Ser Glu 
    1415                 1420                 1425             


Leu Thr  Leu Gly Gln Ile Trp  Asp Val Asp Leu Gln  Lys Asn Glu 
    1430                 1435                 1440             


Ala Ile  Val Lys Asp Val Leu  Leu Val Ala Gln Gly  Glu Met Ala 
    1445                 1450                 1455             


Leu Glu  Glu Phe Leu Lys Gln  Ile Arg Glu Val Trp  Asn Thr Tyr 
    1460                 1465                 1470             


Glu Leu  Asp Leu Val Asn Tyr  Gln Asn Lys Cys Arg  Leu Ile Arg 
    1475                 1480                 1485             


Gly Trp  Asp Asp Leu Phe Asn  Lys Val Lys Glu His  Ile Asn Ser 
    1490                 1495                 1500             


Val Ser  Ala Met Lys Leu Ser  Pro Tyr Tyr Lys Val  Phe Glu Glu 
    1505                 1510                 1515             


Asp Ala  Leu Ser Trp Glu Asp  Lys Leu Asn Arg Ile  Met Ala Leu 
    1520                 1525                 1530             


Phe Asp  Val Trp Ile Asp Val  Gln Arg Arg Trp Val  Tyr Leu Glu 
    1535                 1540                 1545             


Gly Ile  Phe Thr Gly Ser Ala  Asp Ile Lys His Leu  Leu Pro Val 
    1550                 1555                 1560             


Glu Thr  Gln Arg Phe Gln Ser  Ile Ser Thr Glu Phe  Leu Ala Leu 
    1565                 1570                 1575             


Met Lys  Lys Val Ser Lys Ser  Pro Leu Val Met Asp  Val Leu Asn 
    1580                 1585                 1590             


Ile Gln  Gly Val Gln Arg Ser  Leu Glu Arg Leu Ala  Asp Leu Leu 
    1595                 1600                 1605             


Gly Lys  Ile Gln Lys Ala Leu  Gly Glu Tyr Leu Glu  Arg Glu Arg 
    1610                 1615                 1620             


Ser Ser  Phe Pro Arg Phe Tyr  Phe Val Gly Asp Glu  Asp Leu Leu 
    1625                 1630                 1635             


Glu Ile  Ile Gly Asn Ser Lys  Asn Val Ala Lys Leu  Gln Lys His 
    1640                 1645                 1650             


Phe Lys  Lys Met Phe Ala Gly  Val Ser Ser Ile Ile  Leu Asn Glu 
    1655                 1660                 1665             


Asp Asn  Ser Val Val Leu Gly  Ile Ser Ser Arg Glu  Gly Glu Glu 
    1670                 1675                 1680             


Val Met  Phe Lys Thr Pro Val  Ser Ile Thr Glu His  Pro Lys Ile 
    1685                 1690                 1695             


Asn Glu  Trp Leu Thr Leu Val  Glu Lys Glu Met Arg  Val Thr Leu 
    1700                 1705                 1710             


Ala Lys  Leu Leu Ala Glu Ser  Val Thr Glu Val Glu  Ile Phe Gly 
    1715                 1720                 1725             


Lys Ala  Thr Ser Ile Asp Pro  Asn Thr Tyr Ile Thr  Trp Ile Asp 
    1730                 1735                 1740             


Lys Tyr  Gln Ala Gln Leu Val  Val Leu Ser Ala Gln  Ile Ala Trp 
    1745                 1750                 1755             


Ser Glu  Asn Val Glu Thr Ala  Leu Ser Ser Met Gly  Gly Gly Gly 
    1760                 1765                 1770             


Asp Ala  Ala Pro Leu His Ser  Val Leu Ser Asn Val  Glu Val Thr 
    1775                 1780                 1785             


Leu Asn  Val Leu Ala Asp Ser  Val Leu Met Glu Gln  Pro Pro Leu 
    1790                 1795                 1800             


Arg Arg  Arg Lys Leu Glu His  Leu Ile Thr Glu Leu  Val His Gln 
    1805                 1810                 1815             


Arg Asp  Val Thr Arg Ser Leu  Ile Lys Ser Lys Ile  Asp Asn Ala 
    1820                 1825                 1830             


Lys Ser  Phe Glu Trp Leu Ser  Gln Met Arg Phe Tyr  Phe Asp Pro 
    1835                 1840                 1845             


Lys Gln  Thr Asp Val Leu Gln  Gln Leu Ser Ile Gln  Met Ala Asn 
    1850                 1855                 1860             


Ala Lys  Phe Asn Tyr Gly Phe  Glu Tyr Leu Gly Val  Gln Asp Lys 
    1865                 1870                 1875             


Leu Val  Gln Thr Pro Leu Thr  Asp Arg Cys Tyr Leu  Thr Met Thr 
    1880                 1885                 1890             


Gln Ala  Leu Glu Ala Arg Leu  Gly Gly Ser Pro Phe  Gly Pro Ala 
    1895                 1900                 1905             


Gly Thr  Gly Lys Thr Glu Ser  Val Lys Ala Leu Gly  His Gln Leu 
    1910                 1915                 1920             


Gly Arg  Phe Val Leu Val Phe  Asn Cys Asp Glu Thr  Phe Asp Phe 
    1925                 1930                 1935             


Gln Ala  Met Gly Arg Ile Phe  Val Gly Leu Cys Gln  Val Gly Ala 
    1940                 1945                 1950             


Trp Gly  Cys Phe Asp Glu Phe  Asn Arg Leu Glu Glu  Arg Met Leu 
    1955                 1960                 1965             


Ser Ala  Val Ser Gln Gln Val  Gln Cys Ile Gln Glu  Ala Leu Arg 
    1970                 1975                 1980             


Glu His  Ser Asn Pro Asn Tyr  Asp Lys Thr Ser Ala  Pro Ile Thr 
    1985                 1990                 1995             


Cys Glu  Leu Leu Asn Lys Gln  Val Lys Val Ser Pro  Asp Met Ala 
    2000                 2005                 2010             


Ile Phe  Ile Thr Met Asn Pro  Gly Tyr Ala Gly Arg  Ser Asn Leu 
    2015                 2020                 2025             


Pro Asp  Asn Leu Lys Lys Leu  Phe Arg Ser Leu Ala  Met Thr Lys 
    2030                 2035                 2040             


Pro Asp  Arg Gln Leu Ile Ala  Gln Val Met Leu Tyr  Ser Gln Gly 
    2045                 2050                 2055             


Phe Arg  Thr Ala Glu Val Leu  Ala Asn Lys Ile Val  Pro Phe Phe 
    2060                 2065                 2070             


Lys Leu  Cys Asp Glu Gln Leu  Ser Ser Gln Ser His  Tyr Asp Phe 
    2075                 2080                 2085             


Gly Leu  Arg Ala Leu Lys Ser  Val Leu Val Ser Ala  Gly Asn Val 
    2090                 2095                 2100             


Lys Arg  Glu Arg Ile Gln Lys  Ile Lys Arg Glu Lys  Glu Glu Arg 
    2105                 2110                 2115             


Gly Glu  Ala Val Asp Glu Gly  Glu Ile Ala Glu Asn  Leu Pro Glu 
    2120                 2125                 2130             


Gln Glu  Ile Leu Ile Gln Ser  Val Cys Glu Thr Met  Val Pro Lys 
    2135                 2140                 2145             


Leu Val  Ala Glu Asp Ile Pro  Leu Leu Phe Ser Leu  Leu Ser Asp 
    2150                 2155                 2160             


Val Phe  Pro Gly Val Gln Tyr  His Arg Gly Glu Met  Thr Ala Leu 
    2165                 2170                 2175             


Arg Glu  Glu Leu Lys Lys Val  Cys Gln Glu Met Tyr  Leu Thr Tyr 
    2180                 2185                 2190             


Gly Asp  Gly Glu Glu Val Gly  Gly Met Trp Val Glu  Lys Val Leu 
    2195                 2200                 2205             


Gln Leu  Tyr Gln Ile Thr Gln  Ile Asn His Gly Leu  Met Met Val 
    2210                 2215                 2220             


Gly Pro  Ser Gly Ser Gly Lys  Ser Met Ala Trp Arg  Val Leu Leu 
    2225                 2230                 2235             


Lys Ala  Leu Glu Arg Leu Glu  Gly Val Glu Gly Val  Ala His Ile 
    2240                 2245                 2250             


Ile Asp  Pro Lys Ala Ile Ser  Lys Asp His Leu Tyr  Gly Thr Leu 
    2255                 2260                 2265             


Asp Pro  Asn Thr Arg Glu Trp  Thr Asp Gly Leu Phe  Thr His Val 
    2270                 2275                 2280             


Leu Arg  Lys Ile Ile Asp Ser  Val Arg Gly Glu Leu  Gln Lys Arg 
    2285                 2290                 2295             


Gln Trp  Ile Val Phe Asp Gly  Asp Val Asp Pro Glu  Trp Val Glu 
    2300                 2305                 2310             


Asn Leu  Asn Ser Val Leu Asp  Asp Asn Lys Leu Leu  Thr Leu Pro 
    2315                 2320                 2325             


Asn Gly  Glu Arg Leu Ser Leu  Pro Pro Asn Val Arg  Ile Met Phe 
    2330                 2335                 2340             


Glu Val  Gln Asp Leu Lys Tyr  Ala Thr Leu Ala Thr  Val Ser Arg 
    2345                 2350                 2355             


Cys Gly  Met Val Trp Phe Ser  Glu Asp Val Leu Ser  Thr Asp Met 
    2360                 2365                 2370             


Ile Phe  Asn Asn Phe Leu Ala  Arg Leu Arg Ser Ile  Pro Leu Asp 
    2375                 2380                 2385             


Glu Gly  Glu Asp Glu Ala Gln  Arg Arg Arg Lys Gly  Lys Glu Asp 
    2390                 2395                 2400             


Glu Gly  Glu Glu Ala Ala Ser  Pro Met Leu Gln Ile  Gln Arg Asp 
    2405                 2410                 2415             


Ala Ala  Thr Ile Met Gln Pro  Tyr Phe Thr Ser Asn  Gly Leu Val 
    2420                 2425                 2430             


Thr Lys  Ala Leu Glu His Ala  Phe Gln Leu Glu His  Ile Met Asp 
    2435                 2440                 2445             


Leu Thr  Arg Leu Arg Cys Leu  Gly Ser Leu Phe Ser  Met Leu His 
    2450                 2455                 2460             


Gln Ala  Cys Arg Asn Val Ala  Gln Tyr Asn Ala Asn  His Pro Asp 
    2465                 2470                 2475             


Phe Pro  Met Gln Ile Glu Gln  Leu Glu Arg Tyr Ile  Gln Arg Tyr 
    2480                 2485                 2490             


Leu Val  Tyr Ala Ile Leu Trp  Ser Leu Ser Gly Asp  Ser Arg Leu 
    2495                 2500                 2505             


Lys Met  Arg Ala Glu Leu Gly  Glu Tyr Ile Arg Arg  Ile Thr Thr 
    2510                 2515                 2520             


Val Pro  Leu Pro Thr Ala Pro  Asn Ile Pro Ile Ile  Asp Tyr Glu 
    2525                 2530                 2535             


Val Ser  Ile Ser Gly Glu Trp  Ser Pro Trp Gln Ala  Lys Val Pro 
    2540                 2545                 2550             


Gln Ile  Glu Val Glu Thr His  Lys Val Ala Ala Pro  Asp Val Val 
    2555                 2560                 2565             


Val Pro  Thr Leu Asp Thr Val  Arg His Glu Ala Leu  Leu Tyr Thr 
    2570                 2575                 2580             


Trp Leu  Ala Glu His Lys Pro  Leu Val Leu Cys Gly  Pro Pro Gly 
    2585                 2590                 2595             


Ser Gly  Lys Thr Met Thr Leu  Phe Ser Ala Leu Arg  Ala Leu Pro 
    2600                 2605                 2610             


Asp Met  Glu Val Val Gly Leu  Asn Phe Ser Ser Ala  Thr Thr Pro 
    2615                 2620                 2625             


Glu Leu  Leu Leu Lys Thr Phe  Asp His Tyr Cys Glu  Tyr Arg Arg 
    2630                 2635                 2640             


Thr Pro  Asn Gly Val Val Leu  Ala Pro Val Gln Leu  Gly Lys Trp 
    2645                 2650                 2655             


Leu Val  Leu Phe Cys Asp Glu  Ile Asn Leu Pro Asp  Met Asp Lys 
    2660                 2665                 2670             


Tyr Gly  Thr Gln Arg Val Ile  Ser Phe Ile Arg Gln  Met Val Glu 
    2675                 2680                 2685             


His Gly  Gly Phe Tyr Arg Thr  Ser Asp Gln Thr Trp  Val Lys Leu 
    2690                 2695                 2700             


Glu Arg  Ile Gln Phe Val Gly  Ala Cys Asn Pro Pro  Thr Asp Pro 
    2705                 2710                 2715             


Gly Arg  Lys Pro Leu Ser His  Arg Phe Leu Arg His  Val Pro Val 
    2720                 2725                 2730             


Val Tyr  Val Asp Tyr Pro Gly  Pro Ala Ser Leu Thr  Gln Ile Tyr 
    2735                 2740                 2745             


Gly Thr  Phe Asn Arg Ala Met  Leu Arg Leu Ile Pro  Ser Leu Arg 
    2750                 2755                 2760             


Thr Tyr  Ala Glu Pro Leu Thr  Ala Ala Met Val Glu  Phe Tyr Thr 
    2765                 2770                 2775             


Met Ser  Gln Glu Arg Phe Thr  Gln Asp Thr Gln Pro  His Tyr Ile 
    2780                 2785                 2790             


Tyr Ser  Pro Arg Glu Met Thr  Arg Trp Val Arg Gly  Ile Phe Glu 
    2795                 2800                 2805             


Ala Leu  Arg Pro Leu Glu Thr  Leu Pro Val Glu Gly  Leu Ile Arg 
    2810                 2815                 2820             


Ile Trp  Ala His Glu Ala Leu  Arg Leu Phe Gln Asp  Arg Leu Val 
    2825                 2830                 2835             


Glu Asp  Glu Glu Arg Arg Trp  Thr Asp Glu Asn Ile  Asp Thr Val 
    2840                 2845                 2850             


Ala Leu  Lys His Phe Pro Asn  Ile Asp Arg Glu Lys  Ala Met Ser 
    2855                 2860                 2865             


Arg Pro  Ile Leu Tyr Ser Asn  Trp Leu Ser Lys Asp  Tyr Ile Pro 
    2870                 2875                 2880             


Val Asp  Gln Glu Glu Leu Arg  Asp Tyr Val Lys Ala  Arg Leu Lys 
    2885                 2890                 2895             


Val Phe  Tyr Glu Glu Glu Leu  Asp Val Pro Leu Val  Leu Phe Asn 
    2900                 2905                 2910             


Glu Val  Leu Asp His Val Leu  Arg Ile Asp Arg Ile  Phe Arg Gln 
    2915                 2920                 2925             


Pro Gln  Gly His Leu Leu Leu  Ile Gly Val Ser Gly  Ala Gly Lys 
    2930                 2935                 2940             


Thr Thr  Leu Ser Arg Phe Val  Ala Trp Met Asn Gly  Leu Ser Val 
    2945                 2950                 2955             


Tyr Gln  Ile Lys Val His Arg  Lys Tyr Thr Gly Glu  Asp Phe Asp 
    2960                 2965                 2970             


Glu Asp  Leu Arg Thr Val Leu  Arg Arg Ser Gly Cys  Lys Asn Glu 
    2975                 2980                 2985             


Lys Ile  Ala Phe Ile Met Asp  Glu Ser Asn Val Leu  Asp Ser Gly 
    2990                 2995                 3000             


Phe Leu  Glu Arg Met Asn Thr  Leu Leu Ala Asn Gly  Glu Val Pro 
    3005                 3010                 3015             


Gly Leu  Phe Glu Gly Asp Glu  Tyr Ala Thr Leu Met  Thr Gln Cys 
    3020                 3025                 3030             


Lys Glu  Gly Ala Gln Lys Glu  Gly Leu Met Leu Asp  Ser His Glu 
    3035                 3040                 3045             


Glu Leu  Tyr Lys Trp Phe Thr  Ser Gln Val Ile Arg  Asn Leu His 
    3050                 3055                 3060             


Val Val  Phe Thr Met Asn Pro  Ser Ser Glu Gly Leu  Lys Asp Arg 
    3065                 3070                 3075             


Ala Ala  Thr Ser Pro Ala Leu  Phe Asn Arg Cys Val  Leu Asn Trp 
    3080                 3085                 3090             


Phe Gly  Asp Trp Ser Thr Glu  Ala Leu Tyr Gln Val  Gly Lys Glu 
    3095                 3100                 3105             


Phe Thr  Ser Lys Met Asp Leu  Glu Lys Pro Asn Tyr  Ile Val Pro 
    3110                 3115                 3120             


Asp Tyr  Met Pro Val Val Tyr  Asp Lys Leu Pro Gln  Pro Pro Ser 
    3125                 3130                 3135             


His Arg  Glu Ala Ile Val Asn  Ser Cys Val Phe Val  His Gln Thr 
    3140                 3145                 3150             


Leu His  Gln Ala Asn Ala Arg  Leu Ala Lys Arg Gly  Gly Arg Thr 
    3155                 3160                 3165             


Met Ala  Ile Thr Pro Arg His  Tyr Leu Asp Phe Ile  Asn His Tyr 
    3170                 3175                 3180             


Ala Asn  Leu Phe His Glu Lys  Arg Ser Glu Leu Glu  Glu Gln Gln 
    3185                 3190                 3195             


Met His  Leu Asn Val Gly Leu  Arg Lys Ile Lys Glu  Thr Val Asp 
    3200                 3205                 3210             


Gln Val  Glu Glu Leu Arg Arg  Asp Leu Arg Ile Lys  Ser Gln Glu 
    3215                 3220                 3225             


Leu Glu  Val Lys Asn Ala Ala  Ala Asn Asp Lys Leu  Lys Lys Met 
    3230                 3235                 3240             


Val Lys  Asp Gln Gln Glu Ala  Glu Lys Lys Lys Val  Met Ser Gln 
    3245                 3250                 3255             


Glu Ile  Gln Glu Gln Leu His  Lys Gln Gln Glu Val  Ile Ala Asp 
    3260                 3265                 3270             


Lys Gln  Met Ser Val Lys Glu  Asp Leu Asp Lys Val  Glu Pro Ala 
    3275                 3280                 3285             


Val Ile  Glu Ala Gln Asn Ala  Val Lys Ser Ile Lys  Lys Gln His 
    3290                 3295                 3300             


Leu Val  Glu Val Arg Ser Met  Ala Asn Pro Pro Ala  Ala Val Lys 
    3305                 3310                 3315             


Leu Ala  Leu Glu Ser Ile Cys  Leu Leu Leu Gly Glu  Ser Thr Thr 
    3320                 3325                 3330             


Asp Trp  Lys Gln Ile Arg Ser  Ile Ile Met Arg Glu  Asn Phe Ile 
    3335                 3340                 3345             


Pro Thr  Ile Val Asn Phe Ser  Ala Glu Glu Ile Ser  Asp Ala Ile 
    3350                 3355                 3360             


Arg Glu  Lys Met Lys Lys Asn  Tyr Met Ser Asn Pro  Ser Tyr Asn 
    3365                 3370                 3375             


Tyr Glu  Ile Val Asn Arg Ala  Ser Leu Ala Cys Gly  Pro Met Val 
    3380                 3385                 3390             


Lys Trp  Ala Ile Ala Gln Leu  Asn Tyr Ala Asp Met  Leu Lys Arg 
    3395                 3400                 3405             


Val Glu  Pro Leu Arg Asn Glu  Leu Gln Lys Leu Glu  Asp Asp Ala 
    3410                 3415                 3420             


Lys Asp  Asn Gln Gln Lys Ala  Asn Glu Val Glu Gln  Met Ile Arg 
    3425                 3430                 3435             


Asp Leu  Glu Ala Ser Ile Ala  Arg Tyr Lys Glu Glu  Tyr Ala Val 
    3440                 3445                 3450             


Leu Ile  Ser Glu Ala Gln Ala  Ile Lys Ala Asp Leu  Ala Ala Val 
    3455                 3460                 3465             


Glu Ala  Lys Val Asn Arg Ser  Thr Ala Leu Leu Lys  Ser Leu Ser 
    3470                 3475                 3480             


Ala Glu  Arg Glu Arg Trp Glu  Lys Thr Ser Glu Thr  Phe Lys Asn 
    3485                 3490                 3495             


Gln Met  Ser Thr Ile Ala Gly  Asp Cys Leu Leu Ser  Ala Ala Phe 
    3500                 3505                 3510             


Ile Ala  Tyr Ala Gly Tyr Phe  Asp Gln Gln Met Arg  Gln Asn Leu 
    3515                 3520                 3525             


Phe Thr  Thr Trp Ser His His  Leu Gln Gln Ala Asn  Ile Gln Phe 
    3530                 3535                 3540             


Arg Thr  Asp Ile Ala Arg Thr  Glu Tyr Leu Ser Asn  Ala Asp Glu 
    3545                 3550                 3555             


Arg Leu  Arg Trp Gln Ala Ser  Ser Leu Pro Ala Asp  Asp Leu Cys 
    3560                 3565                 3570             


Thr Glu  Asn Ala Ile Met Leu  Lys Arg Phe Asn Arg  Tyr Pro Leu 
    3575                 3580                 3585             


Ile Ile  Asp Pro Ser Gly Gln  Ala Thr Glu Phe Ile  Met Asn Glu 
    3590                 3595                 3600             


Tyr Lys  Asp Arg Lys Ile Thr  Arg Thr Ser Phe Leu  Asp Asp Ala 
    3605                 3610                 3615             


Phe Arg  Lys Asn Leu Glu Ser  Ala Leu Arg Phe Gly  Asn Pro Leu 
    3620                 3625                 3630             


Leu Val  Gln Asp Val Glu Ser  Tyr Asp Pro Val Leu  Asn Pro Val 
    3635                 3640                 3645             


Leu Asn  Arg Glu Val Arg Arg  Thr Gly Gly Arg Val  Leu Ile Thr 
    3650                 3655                 3660             


Leu Gly  Asp Gln Asp Ile Asp  Leu Ser Pro Ser Phe  Val Ile Phe 
    3665                 3670                 3675             


Leu Ser  Thr Arg Asp Pro Thr  Val Glu Phe Pro Pro  Asp Leu Cys 
    3680                 3685                 3690             


Ser Arg  Val Thr Phe Val Asn  Phe Thr Val Thr Arg  Ser Ser Leu 
    3695                 3700                 3705             


Gln Ser  Gln Cys Leu Asn Glu  Val Leu Lys Ala Glu  Arg Pro Asp 
    3710                 3715                 3720             


Val Asp  Glu Lys Arg Ser Asp  Leu Leu Lys Leu Gln  Gly Glu Phe 
    3725                 3730                 3735             


Gln Leu  Arg Leu Arg Gln Leu  Glu Lys Ser Leu Leu  Gln Ala Leu 
    3740                 3745                 3750             


Asn Glu  Val Lys Gly Arg Ile  Leu Asp Asp Asp Thr  Ile Ile Thr 
    3755                 3760                 3765             


Thr Leu  Glu Asn Leu Lys Arg  Glu Ala Ala Glu Val  Thr Arg Lys 
    3770                 3775                 3780             


Val Glu  Glu Thr Asp Ile Val  Met Gln Glu Val Glu  Thr Val Ser 
    3785                 3790                 3795             


Gln Gln  Tyr Leu Pro Leu Ser  Thr Ala Cys Ser Ser  Ile Tyr Phe 
    3800                 3805                 3810             


Thr Met  Glu Ser Leu Lys Gln  Ile His Phe Leu Tyr  Gln Tyr Ser 
    3815                 3820                 3825             


Leu Gln  Phe Phe Leu Asp Ile  Tyr His Asn Val Leu  Tyr Glu Asn 
    3830                 3835                 3840             


Pro Asn  Leu Lys Gly Val Thr  Asp His Thr Gln Arg  Leu Ser Ile 
    3845                 3850                 3855             


Ile Thr  Lys Asp Leu Phe Gln  Val Ala Phe Asn Arg  Val Ala Arg 
    3860                 3865                 3870             


Gly Met  Leu His Gln Asp His  Ile Thr Phe Ala Met  Leu Leu Ala 
    3875                 3880                 3885             


Arg Ile  Lys Leu Lys Gly Thr  Val Gly Glu Pro Thr  Tyr Asp Ala 
    3890                 3895                 3900             


Glu Phe  Gln His Phe Leu Arg  Gly Asn Glu Ile Val  Leu Ser Ala 
    3905                 3910                 3915             


Gly Ser  Thr Pro Arg Ile Gln  Gly Leu Thr Val Glu  Gln Ala Glu 
    3920                 3925                 3930             


Ala Val  Val Arg Leu Ser Cys  Leu Pro Ala Phe Lys  Asp Leu Ile 
    3935                 3940                 3945             


Ala Lys  Val Gln Ala Asp Glu  Gln Phe Gly Ile Trp  Leu Asp Ser 
    3950                 3955                 3960             


Ser Ser  Pro Glu Gln Thr Val  Pro Tyr Leu Trp Ser  Glu Glu Thr 
    3965                 3970                 3975             


Pro Ala  Thr Pro Ile Gly Gln  Ala Ile His Arg Leu  Leu Leu Ile 
    3980                 3985                 3990             


Gln Ala  Phe Arg Pro Asp Arg  Leu Leu Ala Met Ala  His Met Phe 
    3995                 4000                 4005             


Val Ser  Thr Asn Leu Gly Glu  Ser Phe Met Ser Ile  Met Glu Gln 
    4010                 4015                 4020             


Pro Leu  Asp Leu Thr His Ile  Val Gly Thr Glu Val  Lys Pro Asn 
    4025                 4030                 4035             


Thr Pro  Val Leu Met Cys Ser  Val Pro Gly Tyr Asp  Ala Ser Gly 
    4040                 4045                 4050             


His Val  Glu Asp Leu Ala Ala  Glu Gln Asn Thr Gln  Ile Thr Ser 
    4055                 4060                 4065             


Ile Ala  Ile Gly Ser Ala Glu  Gly Phe Asn Gln Ala  Asp Lys Ala 
    4070                 4075                 4080             


Ile Asn  Thr Ala Val Lys Ser  Gly Arg Trp Val Met  Leu Lys Asn 
    4085                 4090                 4095             


Val His  Leu Ala Pro Gly Trp  Leu Met Gln Leu Glu  Lys Lys Leu 
    4100                 4105                 4110             


His Ser  Leu Gln Pro His Ala  Cys Phe Arg Leu Phe  Leu Thr Met 
    4115                 4120                 4125             


Glu Ile  Asn Pro Lys Val Pro  Val Asn Leu Leu Arg  Ala Gly Arg 
    4130                 4135                 4140             


Ile Phe  Val Phe Glu Pro Pro  Pro Gly Val Lys Ala  Asn Met Leu 
    4145                 4150                 4155             


Arg Thr  Phe Ser Ser Ile Pro  Val Ser Arg Ile Cys  Lys Ser Pro 
    4160                 4165                 4170             


Asn Glu  Arg Ala Arg Leu Tyr  Phe Leu Leu Ala Trp  Phe His Ala 
    4175                 4180                 4185             


Ile Ile  Gln Glu Arg Leu Arg  Tyr Ala Pro Leu Gly  Trp Ser Lys 
    4190                 4195                 4200             


Lys Tyr  Glu Phe Gly Glu Ser  Asp Leu Arg Ser Ala  Cys Asp Thr 
    4205                 4210                 4215             


Val Asp  Thr Trp Leu Asp Asp  Thr Ala Lys Gly Arg  Gln Asn Ile 
    4220                 4225                 4230             


Ser Pro  Asp Lys Ile Pro Trp  Ser Ala Leu Lys Thr  Leu Met Ala 
    4235                 4240                 4245             


Gln Ser  Ile Tyr Gly Gly Arg  Val Asp Asn Glu Phe  Asp Gln Arg 
    4250                 4255                 4260             


Leu Leu  Asn Thr Phe Leu Glu  Arg Leu Phe Thr Thr  Arg Ser Phe 
    4265                 4270                 4275             


Asp Ser  Glu Phe Lys Leu Ala  Cys Lys Val Asp Gly  His Lys Asp 
    4280                 4285                 4290             


Ile Gln  Met Pro Asp Gly Ile  Arg Arg Glu Glu Phe  Val Gln Trp 
    4295                 4300                 4305             


Val Glu  Leu Leu Pro Asp Thr  Gln Thr Pro Ser Trp  Leu Gly Leu 
    4310                 4315                 4320             


Pro Asn  Asn Ala Glu Arg Val  Leu Leu Thr Thr Gln  Gly Val Asp 
    4325                 4330                 4335             


Met Ile  Ser Lys Met Leu Lys  Met Gln Met Leu Glu  Asp Glu Asp 
    4340                 4345                 4350             


Asp Leu  Ala Tyr Ala Glu Thr  Glu Lys Lys Thr Arg  Thr Asp Ser 
    4355                 4360                 4365             


Thr Ser  Asp Gly Arg Pro Ala  Trp Met Arg Thr Leu  His Thr Thr 
    4370                 4375                 4380             


Ala Ser  Asn Trp Leu His Leu  Ile Pro Gln Thr Leu  Ser His Leu 
    4385                 4390                 4395             


Lys Arg  Thr Val Glu Asn Ile  Lys Asp Pro Leu Phe  Arg Phe Phe 
    4400                 4405                 4410             


Glu Arg  Glu Val Lys Met Gly  Ala Lys Leu Leu Gln  Asp Val Arg 
    4415                 4420                 4425             


Gln Asp  Leu Ala Asp Val Val  Gln Val Cys Glu Gly  Lys Lys Lys 
    4430                 4435                 4440             


Gln Thr  Asn Tyr Leu Arg Thr  Leu Ile Asn Glu Leu  Val Lys Gly 
    4445                 4450                 4455             


Ile Leu  Pro Arg Ser Trp Ser  His Tyr Thr Val Pro  Ala Gly Met 
    4460                 4465                 4470             


Thr Val  Ile Gln Trp Val Ser  Asp Phe Ser Glu Arg  Ile Lys Gln 
    4475                 4480                 4485             


Leu Gln  Asn Ile Ser Leu Ala  Ala Ala Ser Gly Gly  Ala Lys Glu 
    4490                 4495                 4500             


Leu Lys  Asn Ile His Val Cys  Leu Gly Gly Leu Phe  Val Pro Glu 
    4505                 4510                 4515             


Ala Tyr  Ile Thr Ala Thr Arg  Gln Tyr Val Ala Gln  Ala Asn Ser 
    4520                 4525                 4530             


Trp Ser  Leu Glu Glu Leu Cys  Leu Glu Val Asn Val  Thr Thr Ser 
    4535                 4540                 4545             


Gln Gly  Ala Thr Leu Asp Ala  Cys Ser Phe Gly Val  Thr Gly Leu 
    4550                 4555                 4560             


Lys Leu  Gln Gly Ala Thr Cys  Asn Asn Asn Lys Leu  Ser Leu Ser 
    4565                 4570                 4575             


Asn Ala  Ile Ser Thr Ala Leu  Pro Leu Thr Gln Leu  Arg Trp Val 
    4580                 4585                 4590             


Lys Gln  Thr Asn Thr Glu Lys  Lys Ala Ser Val Val  Thr Leu Pro 
    4595                 4600                 4605             


Val Tyr  Leu Asn Phe Thr Arg  Ala Asp Leu Ile Phe  Thr Val Asp 
    4610                 4615                 4620             


Phe Glu  Ile Ala Thr Lys Glu  Asp Pro Arg Ser Phe  Tyr Glu Arg 
    4625                 4630                 4635             


Gly Val  Ala Val Leu Cys Thr  Glu 
    4640                 4645     


<210>  127
<211>  507
<212>  PRT
<213>  Homo sapiens

<400>  127

Met Arg Arg Leu Pro Arg Ala Leu Leu Leu Gln Leu Arg Leu Ala Leu 
1               5                   10                  15      


Leu Val Ala Ala Gly Ala Pro Glu Val Leu Val Ser Ala Pro Arg Ser 
            20                  25                  30          


Leu Val Trp Gly Pro Gly Leu Gln Ala Ala Val Val Leu Pro Val Arg 
        35                  40                  45              


Tyr Phe Tyr Leu Gln Ala Val Asn Ser Glu Gly Gln Asn Leu Thr Arg 
    50                  55                  60                  


Ser Pro Ala Gly Glu Thr Pro Phe Lys Val Val Val Lys Ser Leu Ser 
65                  70                  75                  80  


Pro Lys Glu Leu Val Arg Ile His Val Pro Lys Pro Leu Asp Arg Asn 
                85                  90                  95      


Asp Gly Thr Phe Leu Met Arg Tyr Arg Met Tyr Glu Thr Val Asp Glu 
            100                 105                 110         


Gly Leu Lys Ile Glu Val Leu Tyr Gly Asp Glu His Val Ala Gln Ser 
        115                 120                 125             


Pro Tyr Ile Leu Lys Gly Pro Val Tyr His Glu Tyr Cys Glu Cys Pro 
    130                 135                 140                 


Glu Asp Pro Gln Ala Trp Gln Lys Thr Leu Ser Cys Pro Thr Lys Glu 
145                 150                 155                 160 


Pro Gln Ile Ala Lys Asp Phe Ala Ser Phe Pro Ser Ile Asn Leu Gln 
                165                 170                 175     


Gln Met Leu Lys Glu Val Pro Lys Arg Phe Gly Asp Glu Arg Gly Ala 
            180                 185                 190         


Ile Val His Tyr Thr Ile Leu Asn Asn His Val Tyr Arg Arg Ser Leu 
        195                 200                 205             


Gly Lys Tyr Thr Asp Phe Lys Met Phe Ser Asp Glu Ile Leu Leu Ser 
    210                 215                 220                 


Leu Thr Arg Lys Val Leu Leu Pro Asp Leu Glu Phe Tyr Val Asn Leu 
225                 230                 235                 240 


Gly Asp Trp Pro Leu Glu His Arg Lys Val Asn Gly Thr Pro Ser Pro 
                245                 250                 255     


Ile Pro Ile Ile Ser Trp Cys Gly Ser Leu Asp Ser Arg Asp Val Val 
            260                 265                 270         


Leu Pro Thr Tyr Asp Ile Thr His Ser Met Leu Glu Ala Met Arg Gly 
        275                 280                 285             


Val Thr Asn Asp Leu Leu Ser Ile Gln Gly Asn Thr Gly Pro Ser Trp 
    290                 295                 300                 


Ile Asn Lys Thr Glu Arg Ala Phe Phe Arg Gly Arg Asp Ser Arg Glu 
305                 310                 315                 320 


Glu Arg Leu Gln Leu Val Gln Leu Ser Lys Glu Asn Pro Gln Leu Leu 
                325                 330                 335     


Asp Ala Gly Ile Thr Gly Tyr Phe Phe Phe Gln Glu Lys Glu Lys Glu 
            340                 345                 350         


Leu Gly Lys Ala Lys Leu Met Gly Phe Phe Asp Phe Phe Lys Tyr Lys 
        355                 360                 365             


Tyr Gln Val Asn Val Asp Gly Thr Val Ala Ala Tyr Arg Tyr Pro Tyr 
    370                 375                 380                 


Leu Met Leu Gly Asp Ser Leu Val Leu Lys Gln Asp Ser Pro Tyr Tyr 
385                 390                 395                 400 


Glu His Phe Tyr Met Ala Leu Glu Pro Trp Lys His Tyr Val Pro Ile 
                405                 410                 415     


Lys Arg Asn Leu Ser Asp Leu Leu Glu Lys Val Lys Trp Ala Lys Glu 
            420                 425                 430         


Asn Asp Glu Glu Ala Lys Lys Ile Ala Lys Glu Gly Gln Leu Met Ala 
        435                 440                 445             


Arg Asp Leu Leu Gln Pro His Arg Leu Tyr Cys Tyr Tyr Tyr Gln Val 
    450                 455                 460                 


Leu Gln Lys Tyr Ala Glu Arg Gln Ser Ser Lys Pro Glu Val Arg Asp 
465                 470                 475                 480 


Gly Met Glu Leu Val Pro Gln Pro Glu Asp Ser Thr Ala Ile Cys Gln 
                485                 490                 495     


Cys His Arg Lys Lys Pro Ser Arg Glu Glu Leu 
            500                 505         


<210>  128
<211>  332
<212>  PRT
<213>  Homo sapiens

<400>  128

Met Ser Glu Ala Gly Glu Glu Gln Pro Met Glu Thr Thr Gly Ala Thr 
1               5                   10                  15      


Glu Asn Gly His Glu Ala Val Pro Glu Ala Ser Arg Gly Arg Gly Trp 
            20                  25                  30          


Thr Gly Ala Ala Ala Gly Ala Gly Gly Ala Thr Ala Ala Pro Pro Ser 
        35                  40                  45              


Gly Asn Gln Asn Gly Ala Glu Gly Asp Gln Ile Asn Ala Ser Lys Asn 
    50                  55                  60                  


Glu Glu Asp Ala Gly Lys Met Phe Val Gly Gly Leu Ser Trp Asp Thr 
65                  70                  75                  80  


Ser Lys Lys Asp Leu Lys Asp Tyr Phe Thr Lys Phe Gly Glu Val Val 
                85                  90                  95      


Asp Cys Thr Ile Lys Met Asp Pro Asn Thr Gly Arg Ser Arg Gly Phe 
            100                 105                 110         


Gly Phe Ile Leu Phe Lys Asp Ala Ala Ser Val Glu Lys Val Leu Asp 
        115                 120                 125             


Gln Lys Glu His Arg Leu Asp Gly Arg Val Ile Asp Pro Lys Lys Ala 
    130                 135                 140                 


Met Ala Met Lys Lys Asp Pro Val Lys Lys Ile Phe Val Gly Gly Leu 
145                 150                 155                 160 


Asn Pro Glu Ser Pro Thr Glu Glu Lys Ile Arg Glu Tyr Phe Gly Glu 
                165                 170                 175     


Phe Gly Glu Ile Glu Ala Ile Glu Leu Pro Met Asp Pro Lys Leu Asn 
            180                 185                 190         


Lys Arg Arg Gly Phe Val Phe Ile Thr Phe Lys Glu Glu Glu Pro Val 
        195                 200                 205             


Lys Lys Val Leu Glu Lys Lys Phe His Thr Val Ser Gly Ser Lys Cys 
    210                 215                 220                 


Glu Ile Lys Val Ala Gln Pro Lys Glu Val Tyr Gln Gln Gln Gln Tyr 
225                 230                 235                 240 


Gly Ser Gly Gly Arg Gly Asn Arg Asn Arg Gly Asn Arg Gly Ser Gly 
                245                 250                 255     


Gly Gly Gly Gly Gly Gly Gly Gln Ser Gln Ser Trp Asn Gln Gly Tyr 
            260                 265                 270         


Gly Asn Tyr Trp Asn Gln Gly Tyr Gly Tyr Gln Gln Gly Tyr Gly Pro 
        275                 280                 285             


Gly Tyr Gly Gly Tyr Asp Tyr Ser Pro Tyr Gly Tyr Tyr Gly Tyr Gly 
    290                 295                 300                 


Pro Gly Tyr Asp Tyr Ser Gln Gly Ser Thr Asn Tyr Gly Lys Ser Gln 
305                 310                 315                 320 


Arg Arg Gly Gly His Gln Asn Asn Tyr Lys Pro Tyr 
                325                 330         


<210>  129
<211>  547
<212>  PRT
<213>  Homo sapiens

<400>  129

Met Glu Asp Ser Glu Ala Leu Gly Phe Glu His Met Gly Leu Asp Pro 
1               5                   10                  15      


Arg Leu Leu Gln Ala Val Thr Asp Leu Gly Trp Ser Arg Pro Thr Leu 
            20                  25                  30          


Ile Gln Glu Lys Ala Ile Pro Leu Ala Leu Glu Gly Lys Asp Leu Leu 
        35                  40                  45              


Ala Arg Ala Arg Thr Gly Ser Gly Lys Thr Ala Ala Tyr Ala Ile Pro 
    50                  55                  60                  


Met Leu Gln Leu Leu Leu His Arg Lys Ala Thr Gly Pro Val Val Glu 
65                  70                  75                  80  


Gln Ala Val Arg Gly Leu Val Leu Val Pro Thr Lys Glu Leu Ala Arg 
                85                  90                  95      


Gln Ala Gln Ser Met Ile Gln Gln Leu Ala Thr Tyr Cys Ala Arg Asp 
            100                 105                 110         


Val Arg Val Ala Asn Val Ser Ala Ala Glu Asp Ser Val Ser Gln Arg 
        115                 120                 125             


Ala Val Leu Met Glu Lys Pro Asp Val Val Val Gly Thr Pro Ser Arg 
    130                 135                 140                 


Ile Leu Ser His Leu Gln Gln Asp Ser Leu Lys Leu Arg Asp Ser Leu 
145                 150                 155                 160 


Glu Leu Leu Val Val Asp Glu Ala Asp Leu Leu Phe Ser Phe Gly Phe 
                165                 170                 175     


Glu Glu Glu Leu Lys Ser Leu Leu Cys His Leu Pro Arg Ile Tyr Gln 
            180                 185                 190         


Ala Phe Leu Met Ser Ala Thr Phe Asn Glu Asp Val Gln Ala Leu Lys 
        195                 200                 205             


Glu Leu Ile Leu His Asn Pro Val Thr Leu Lys Leu Gln Glu Ser Gln 
    210                 215                 220                 


Leu Pro Gly Pro Asp Gln Leu Gln Gln Phe Gln Val Val Cys Glu Thr 
225                 230                 235                 240 


Glu Glu Asp Lys Phe Leu Leu Leu Tyr Ala Leu Leu Lys Leu Ser Leu 
                245                 250                 255     


Ile Arg Gly Lys Ser Leu Leu Phe Val Asn Thr Leu Glu Arg Ser Tyr 
            260                 265                 270         


Arg Leu Arg Leu Phe Leu Glu Gln Phe Ser Ile Pro Thr Cys Val Leu 
        275                 280                 285             


Asn Gly Glu Leu Pro Leu Arg Ser Arg Cys His Ile Ile Ser Gln Phe 
    290                 295                 300                 


Asn Gln Gly Phe Tyr Asp Cys Val Ile Ala Thr Asp Ala Glu Val Leu 
305                 310                 315                 320 


Gly Ala Pro Val Lys Gly Lys Arg Arg Gly Arg Gly Pro Lys Gly Asp 
                325                 330                 335     


Lys Ala Ser Asp Pro Glu Ala Gly Val Ala Arg Gly Ile Asp Phe His 
            340                 345                 350         


His Val Ser Ala Val Leu Asn Phe Asp Leu Pro Pro Thr Pro Glu Ala 
        355                 360                 365             


Tyr Ile His Arg Ala Gly Arg Thr Ala Arg Ala Asn Asn Pro Gly Ile 
    370                 375                 380                 


Val Leu Thr Phe Val Leu Pro Thr Glu Gln Phe His Leu Gly Lys Ile 
385                 390                 395                 400 


Glu Glu Leu Leu Ser Gly Glu Asn Arg Gly Pro Ile Leu Leu Pro Tyr 
                405                 410                 415     


Gln Phe Arg Met Glu Glu Ile Glu Gly Phe Arg Tyr Arg Cys Arg Asp 
            420                 425                 430         


Ala Met Arg Ser Val Thr Lys Gln Ala Ile Arg Glu Ala Arg Leu Lys 
        435                 440                 445             


Glu Ile Lys Glu Glu Leu Leu His Ser Glu Lys Leu Lys Thr Tyr Phe 
    450                 455                 460                 


Glu Asp Asn Pro Arg Asp Leu Gln Leu Leu Arg His Asp Leu Pro Leu 
465                 470                 475                 480 


His Pro Ala Val Val Lys Pro His Leu Gly His Val Pro Asp Tyr Leu 
                485                 490                 495     


Val Pro Pro Ala Leu Arg Gly Leu Val Arg Pro His Lys Lys Arg Lys 
            500                 505                 510         


Lys Leu Ser Ser Ser Cys Arg Lys Ala Lys Arg Ala Lys Ser Gln Asn 
        515                 520                 525             


Pro Leu Arg Ser Phe Lys His Lys Gly Lys Lys Phe Arg Pro Thr Ala 
    530                 535                 540                 


Lys Pro Ser 
545         


<210>  130
<211>  483
<212>  PRT
<213>  Homo sapiens

<400>  130

Met Ser Ser Lys His Arg Ile Cys Ser Gln Glu Glu Val Val Ile Pro 
1               5                   10                  15      


Cys Ala Tyr Asp Ser Asp Ser Glu Ser Val Asp Leu Glu Leu Ser Asn 
            20                  25                  30          


Leu Glu Ile Ile Lys Lys Gly Ser Ser Ser Ile Glu Leu Thr Asp Leu 
        35                  40                  45              


Asp Ile Pro Asp Ile Pro Gly Leu His Cys Glu Pro Leu Ser His Ser 
    50                  55                  60                  


Pro Arg His Leu Thr Gln Gln Asp Pro Leu Ser Glu Ala Ile Val Glu 
65                  70                  75                  80  


Lys Leu Ile Gln Ser Ile Gln Lys Val Phe Asn Gly Glu Leu Lys Gly 
                85                  90                  95      


Glu Leu Glu Lys Leu Lys Phe Leu Gly Asp Leu Ser Ser Leu Ser Gln 
            100                 105                 110         


Ala Leu Pro Tyr Asp Glu Thr Ala Lys Ser Phe Ile His Ser His Ile 
        115                 120                 125             


Ala Asp Ile Val His Thr Leu Asn Val Leu Val Gln Glu Glu Arg Pro 
    130                 135                 140                 


His Ser Leu Ser Ser Ser Met Arg Gln Glu Val Phe Val Thr Ile Ala 
145                 150                 155                 160 


Asp Leu Ser Tyr Gln Asp Val His Leu Leu Leu Gly Ser Glu Asp Arg 
                165                 170                 175     


Ala Glu Leu Phe Ser Leu Thr Ile Lys Ser Ile Ile Thr Leu Pro Ser 
            180                 185                 190         


Val Arg Thr Leu Thr Gln Ile Gln Glu Ile Met Pro Asn Gly Thr Cys 
        195                 200                 205             


Asn Thr Glu Cys Leu Tyr Arg Gln Thr Phe Gln Ala Phe Ser Glu Met 
    210                 215                 220                 


Leu Gln Ser Leu Val Val Lys Asp Pro His Leu Glu Asn Leu Asp Thr 
225                 230                 235                 240 


Ile Ile Lys Leu Pro Leu Arg Phe Gln Arg Leu Gly His Leu Val Ala 
                245                 250                 255     


Leu Met Ala Leu Leu Cys Gly Asp Pro Gln Glu Lys Val Ala Glu Glu 
            260                 265                 270         


Ala Ala Glu Gly Ile His Ser Leu Leu His Ile Thr Leu Arg Leu Lys 
        275                 280                 285             


Tyr Ile Thr His Asp Lys Lys Asp Gln Gln Asn Leu Lys Arg Ala Leu 
    290                 295                 300                 


Thr Lys Cys Arg Glu Phe Leu Glu Leu His Ser Ser Ala Ala Lys Cys 
305                 310                 315                 320 


Phe Tyr Asn Cys Pro Phe Arg Ile Ala Gln Val Phe Glu Gly Phe Leu 
                325                 330                 335     


Asp Ser Asn Glu Leu Cys Gln Phe Ile Met Thr Thr Phe Asp Thr Leu 
            340                 345                 350         


Lys Thr Leu Lys His Pro Cys Ile Gln Arg Ser Ala Gly Glu Leu Leu 
        355                 360                 365             


Leu Thr Leu Ala Lys Asn Thr Glu Ser Gln Phe Glu Lys Val Pro Glu 
    370                 375                 380                 


Ile Met Gly Val Ile Cys Ala Gln Leu Ser Ile Ile Ser Gln Pro Arg 
385                 390                 395                 400 


Val Arg Gln Gln Ile Ile Asn Thr Val Ser Leu Phe Ile Ser Arg Pro 
                405                 410                 415     


Lys Tyr Thr Asp Ile Val Leu Ser Phe Leu Leu Cys His Pro Val Pro 
            420                 425                 430         


Tyr Asn Arg His Leu Ala Glu Val Trp Arg Met Leu Ser Val Glu Leu 
        435                 440                 445             


Pro Ser Thr Thr Trp Ile Leu Trp Arg Leu Leu Arg Lys Leu Gln Lys 
    450                 455                 460                 


Cys His Asn Glu Pro Ala Gln Glu Lys Met Ala Tyr Val Ala Val Ala 
465                 470                 475                 480 


Val Ser Pro 
            


<210>  131
<211>  869
<212>  PRT
<213>  Homo sapiens

<400>  131

Met Ala Gly Cys Arg Gly Ser Leu Cys Cys Cys Cys Arg Trp Cys Cys 
1               5                   10                  15      


Cys Cys Gly Glu Arg Glu Thr Arg Thr Pro Glu Glu Leu Thr Ile Leu 
            20                  25                  30          


Gly Glu Thr Gln Glu Glu Glu Asp Glu Ile Leu Pro Arg Lys Asp Tyr 
        35                  40                  45              


Glu Ser Leu Asp Tyr Asp Arg Cys Ile Asn Asp Pro Tyr Leu Glu Val 
    50                  55                  60                  


Leu Glu Thr Met Asp Asn Lys Lys Gly Arg Arg Tyr Glu Ala Val Lys 
65                  70                  75                  80  


Trp Met Val Val Phe Ala Ile Gly Val Cys Thr Gly Leu Val Gly Leu 
                85                  90                  95      


Phe Val Asp Phe Phe Val Arg Leu Phe Thr Gln Leu Lys Phe Gly Val 
            100                 105                 110         


Val Gln Thr Ser Val Glu Glu Cys Ser Gln Lys Gly Cys Leu Ala Leu 
        115                 120                 125             


Ser Leu Leu Glu Leu Leu Gly Phe Asn Leu Thr Phe Val Phe Leu Ala 
    130                 135                 140                 


Ser Leu Leu Val Leu Ile Glu Pro Val Ala Ala Gly Ser Gly Ile Pro 
145                 150                 155                 160 


Glu Val Lys Cys Tyr Leu Asn Gly Val Lys Val Pro Gly Ile Val Arg 
                165                 170                 175     


Leu Arg Thr Leu Leu Cys Lys Val Leu Gly Val Leu Phe Ser Val Ala 
            180                 185                 190         


Gly Gly Leu Phe Val Gly Lys Glu Gly Pro Met Ile His Ser Gly Ser 
        195                 200                 205             


Val Val Gly Ala Gly Leu Pro Gln Phe Gln Ser Ile Ser Leu Arg Lys 
    210                 215                 220                 


Ile Gln Phe Asn Phe Pro Tyr Phe Arg Ser Asp Arg Asp Lys Arg Asp 
225                 230                 235                 240 


Phe Val Ser Ala Gly Ala Ala Ala Gly Val Ala Ala Ala Phe Gly Ala 
                245                 250                 255     


Pro Ile Gly Gly Thr Leu Phe Ser Leu Glu Glu Gly Ser Ser Phe Trp 
            260                 265                 270         


Asn Gln Gly Leu Thr Trp Lys Val Leu Phe Cys Ser Met Ser Ala Thr 
        275                 280                 285             


Phe Thr Leu Asn Phe Phe Arg Ser Gly Ile Gln Phe Gly Ser Trp Gly 
    290                 295                 300                 


Ser Phe Gln Leu Pro Gly Leu Leu Asn Phe Gly Glu Phe Lys Cys Ser 
305                 310                 315                 320 


Asp Ser Asp Lys Lys Cys His Leu Trp Thr Ala Met Asp Leu Gly Phe 
                325                 330                 335     


Phe Val Val Met Gly Val Ile Gly Gly Leu Leu Gly Ala Thr Phe Asn 
            340                 345                 350         


Cys Leu Asn Lys Arg Leu Ala Lys Tyr Arg Met Arg Asn Val His Pro 
        355                 360                 365             


Lys Pro Lys Leu Val Arg Val Leu Glu Ser Leu Leu Val Ser Leu Val 
    370                 375                 380                 


Thr Thr Val Val Val Phe Val Ala Ser Met Val Leu Gly Glu Cys Arg 
385                 390                 395                 400 


Gln Met Ser Ser Ser Ser Gln Ile Gly Asn Asp Ser Phe Gln Leu Gln 
                405                 410                 415     


Val Thr Glu Asp Val Asn Ser Ser Ile Lys Thr Phe Phe Cys Pro Asn 
            420                 425                 430         


Asp Thr Tyr Asn Asp Met Ala Thr Leu Phe Phe Asn Pro Gln Glu Ser 
        435                 440                 445             


Ala Ile Leu Gln Leu Phe His Gln Asp Gly Thr Phe Ser Pro Val Thr 
    450                 455                 460                 


Leu Ala Leu Phe Phe Val Leu Tyr Phe Leu Leu Ala Cys Trp Thr Tyr 
465                 470                 475                 480 


Gly Ile Ser Val Pro Ser Gly Leu Phe Val Pro Ser Leu Leu Cys Gly 
                485                 490                 495     


Ala Ala Phe Gly Arg Leu Val Ala Asn Val Leu Lys Ser Tyr Ile Gly 
            500                 505                 510         


Leu Gly His Ile Tyr Ser Gly Thr Phe Ala Leu Ile Gly Ala Ala Ala 
        515                 520                 525             


Phe Leu Gly Gly Val Val Arg Met Thr Ile Ser Leu Thr Val Ile Leu 
    530                 535                 540                 


Ile Glu Ser Thr Asn Glu Ile Thr Tyr Gly Leu Pro Ile Met Val Thr 
545                 550                 555                 560 


Leu Met Val Ala Lys Trp Thr Gly Asp Phe Phe Asn Lys Gly Ile Tyr 
                565                 570                 575     


Asp Ile His Val Gly Leu Arg Gly Val Pro Leu Leu Glu Trp Glu Thr 
            580                 585                 590         


Glu Val Glu Met Asp Lys Leu Arg Ala Ser Asp Ile Met Glu Pro Asn 
        595                 600                 605             


Leu Thr Tyr Val Tyr Pro His Thr Arg Ile Gln Ser Leu Val Ser Ile 
    610                 615                 620                 


Leu Arg Thr Thr Val His His Ala Phe Pro Val Val Thr Glu Asn Arg 
625                 630                 635                 640 


Gly Asn Glu Lys Glu Phe Met Lys Gly Asn Gln Leu Ile Ser Asn Asn 
                645                 650                 655     


Ile Lys Phe Lys Lys Ser Ser Ile Leu Thr Arg Ala Gly Glu Gln Arg 
            660                 665                 670         


Lys Arg Ser Gln Ser Met Lys Ser Tyr Pro Ser Ser Glu Leu Arg Asn 
        675                 680                 685             


Met Cys Asp Glu His Ile Ala Ser Glu Glu Pro Ala Glu Lys Glu Asp 
    690                 695                 700                 


Leu Leu Gln Gln Met Leu Glu Arg Arg Tyr Thr Pro Tyr Pro Asn Leu 
705                 710                 715                 720 


Tyr Pro Asp Gln Ser Pro Ser Glu Asp Trp Thr Met Glu Glu Arg Phe 
                725                 730                 735     


Arg Pro Leu Thr Phe His Gly Leu Ile Leu Arg Ser Gln Leu Val Thr 
            740                 745                 750         


Leu Leu Val Arg Gly Val Cys Tyr Ser Glu Ser Gln Ser Ser Ala Ser 
        755                 760                 765             


Gln Pro Arg Leu Ser Tyr Ala Glu Met Ala Glu Asp Tyr Pro Arg Tyr 
    770                 775                 780                 


Pro Asp Ile His Asp Leu Asp Leu Thr Leu Leu Asn Pro Arg Met Ile 
785                 790                 795                 800 


Val Asp Val Thr Pro Tyr Met Asn Pro Ser Pro Phe Thr Val Ser Pro 
                805                 810                 815     


Asn Thr His Val Ser Gln Val Phe Asn Leu Phe Arg Thr Met Gly Leu 
            820                 825                 830         


Arg His Leu Pro Val Val Asn Ala Val Gly Glu Ile Val Gly Ile Ile 
        835                 840                 845             


Thr Arg His Asn Leu Thr Tyr Glu Phe Leu Gln Ala Arg Leu Arg Gln 
    850                 855                 860                 


His Tyr Gln Thr Ile 
865                 


<210>  132
<211>  1007
<212>  PRT
<213>  Homo sapiens

<400>  132

Met Ser Arg Arg Lys Gln Arg Lys Pro Gln Gln Leu Ile Ser Asp Cys 
1               5                   10                  15      


Glu Gly Pro Ser Ala Ser Glu Asn Gly Asp Ala Ser Glu Glu Asp His 
            20                  25                  30          


Pro Gln Val Cys Ala Lys Cys Cys Ala Gln Phe Thr Asp Pro Thr Glu 
        35                  40                  45              


Phe Leu Ala His Gln Asn Ala Cys Ser Thr Asp Pro Pro Val Met Val 
    50                  55                  60                  


Ile Ile Gly Gly Gln Glu Asn Pro Asn Asn Ser Ser Ala Ser Ser Glu 
65                  70                  75                  80  


Pro Arg Pro Glu Gly His Asn Asn Pro Gln Val Met Asp Thr Glu His 
                85                  90                  95      


Ser Asn Pro Pro Asp Ser Gly Ser Ser Val Pro Thr Asp Pro Thr Trp 
            100                 105                 110         


Gly Pro Glu Arg Arg Gly Glu Glu Ser Ser Gly His Phe Leu Val Ala 
        115                 120                 125             


Ala Thr Gly Thr Ala Ala Gly Gly Gly Gly Gly Leu Ile Leu Ala Ser 
    130                 135                 140                 


Pro Lys Leu Gly Ala Thr Pro Leu Pro Pro Glu Ser Thr Pro Ala Pro 
145                 150                 155                 160 


Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Val Gly Ser Gly His 
                165                 170                 175     


Leu Asn Ile Pro Leu Ile Leu Glu Glu Leu Arg Val Leu Gln Gln Arg 
            180                 185                 190         


Gln Ile His Gln Met Gln Met Thr Glu Gln Ile Cys Arg Gln Val Leu 
        195                 200                 205             


Leu Leu Gly Ser Leu Gly Gln Thr Val Gly Ala Pro Ala Ser Pro Ser 
    210                 215                 220                 


Glu Leu Pro Gly Thr Gly Thr Ala Ser Ser Thr Lys Pro Leu Leu Pro 
225                 230                 235                 240 


Leu Phe Ser Pro Ile Lys Pro Val Gln Thr Ser Lys Thr Leu Ala Ser 
                245                 250                 255     


Ser Ser Ser Ser Ser Ser Ser Ser Ser Gly Ala Glu Thr Pro Lys Gln 
            260                 265                 270         


Ala Phe Phe His Leu Tyr His Pro Leu Gly Ser Gln His Pro Phe Ser 
        275                 280                 285             


Ala Gly Gly Val Gly Arg Ser His Lys Pro Thr Pro Ala Pro Ser Pro 
    290                 295                 300                 


Ala Leu Pro Gly Ser Thr Asp Gln Leu Ile Ala Ser Pro His Leu Ala 
305                 310                 315                 320 


Phe Pro Ser Thr Thr Gly Leu Leu Ala Ala Gln Cys Leu Gly Ala Ala 
                325                 330                 335     


Arg Gly Leu Glu Ala Thr Ala Ser Pro Gly Leu Leu Lys Pro Lys Asn 
            340                 345                 350         


Gly Ser Gly Glu Leu Ser Tyr Gly Glu Val Met Gly Pro Leu Glu Lys 
        355                 360                 365             


Pro Gly Gly Arg His Lys Cys Arg Phe Cys Ala Lys Val Phe Gly Ser 
    370                 375                 380                 


Asp Ser Ala Leu Gln Ile His Leu Arg Ser His Thr Gly Glu Arg Pro 
385                 390                 395                 400 


Tyr Lys Cys Asn Val Cys Gly Asn Arg Phe Thr Thr Arg Gly Asn Leu 
                405                 410                 415     


Lys Val His Phe His Arg His Arg Glu Lys Tyr Pro His Val Gln Met 
            420                 425                 430         


Asn Pro His Pro Val Pro Glu His Leu Asp Tyr Val Ile Thr Ser Ser 
        435                 440                 445             


Gly Leu Pro Tyr Gly Met Ser Val Pro Pro Glu Lys Ala Glu Glu Glu 
    450                 455                 460                 


Ala Ala Thr Pro Gly Gly Gly Val Glu Arg Lys Pro Leu Val Ala Ser 
465                 470                 475                 480 


Thr Thr Ala Leu Ser Ala Thr Glu Ser Leu Thr Leu Leu Ser Thr Ser 
                485                 490                 495     


Ala Gly Thr Ala Thr Ala Pro Gly Leu Pro Ala Phe Asn Lys Phe Val 
            500                 505                 510         


Leu Met Lys Ala Val Glu Pro Lys Asn Lys Ala Asp Glu Asn Thr Pro 
        515                 520                 525             


Pro Gly Ser Glu Gly Ser Ala Ile Ser Gly Val Ala Glu Ser Ser Thr 
    530                 535                 540                 


Ala Thr Arg Met Gln Leu Ser Lys Leu Val Thr Ser Leu Pro Ser Trp 
545                 550                 555                 560 


Ala Leu Leu Thr Asn His Phe Lys Ser Thr Gly Ser Phe Pro Phe Pro 
                565                 570                 575     


Tyr Val Leu Glu Pro Leu Gly Ala Ser Pro Ser Glu Thr Ser Lys Leu 
            580                 585                 590         


Gln Gln Leu Val Glu Lys Ile Asp Arg Gln Gly Ala Val Ala Val Thr 
        595                 600                 605             


Ser Ala Ala Ser Gly Ala Pro Thr Thr Ser Ala Pro Ala Pro Ser Ser 
    610                 615                 620                 


Ser Ala Ser Ser Gly Pro Asn Gln Cys Val Ile Cys Leu Arg Val Leu 
625                 630                 635                 640 


Ser Cys Pro Arg Ala Leu Arg Leu His Tyr Gly Gln His Gly Gly Glu 
                645                 650                 655     


Arg Pro Phe Lys Cys Lys Val Cys Gly Arg Ala Phe Ser Thr Arg Gly 
            660                 665                 670         


Asn Leu Arg Ala His Phe Val Gly His Lys Ala Ser Pro Ala Ala Arg 
        675                 680                 685             


Ala Gln Asn Ser Cys Pro Ile Cys Gln Lys Lys Phe Thr Asn Ala Val 
    690                 695                 700                 


Thr Leu Gln Gln His Val Arg Met His Leu Gly Gly Gln Ile Pro Asn 
705                 710                 715                 720 


Gly Gly Thr Ala Leu Pro Glu Gly Gly Gly Ala Ala Gln Glu Asn Gly 
                725                 730                 735     


Ser Glu Gln Ser Thr Val Ser Gly Ala Arg Ser Phe Pro Gln Gln Gln 
            740                 745                 750         


Ser Gln Gln Pro Ser Pro Glu Glu Glu Leu Ser Glu Glu Glu Glu Glu 
        755                 760                 765             


Glu Asp Glu Glu Glu Glu Glu Asp Val Thr Asp Glu Asp Ser Leu Ala 
    770                 775                 780                 


Gly Arg Gly Ser Glu Ser Gly Gly Glu Lys Ala Ile Ser Val Arg Gly 
785                 790                 795                 800 


Asp Ser Glu Glu Ala Ser Gly Ala Glu Glu Glu Val Gly Thr Val Ala 
                805                 810                 815     


Ala Ala Ala Thr Ala Gly Lys Glu Met Asp Ser Asn Glu Lys Thr Thr 
            820                 825                 830         


Gln Gln Ser Ser Leu Pro Pro Pro Pro Pro Pro Asp Ser Leu Asp Gln 
        835                 840                 845             


Pro Gln Pro Met Glu Gln Gly Ser Ser Gly Val Leu Gly Gly Lys Glu 
    850                 855                 860                 


Glu Gly Gly Lys Pro Glu Arg Ser Ser Ser Pro Ala Ser Ala Leu Thr 
865                 870                 875                 880 


Pro Glu Gly Glu Ala Thr Ser Val Thr Leu Val Glu Glu Leu Ser Leu 
                885                 890                 895     


Gln Glu Ala Met Arg Lys Glu Pro Gly Glu Ser Ser Ser Arg Lys Ala 
            900                 905                 910         


Cys Glu Val Cys Gly Gln Ala Phe Pro Ser Gln Ala Ala Leu Glu Glu 
        915                 920                 925             


His Gln Lys Thr His Pro Lys Glu Gly Pro Leu Phe Thr Cys Val Phe 
    930                 935                 940                 


Cys Arg Gln Gly Phe Leu Glu Arg Ala Thr Leu Lys Lys His Met Leu 
945                 950                 955                 960 


Leu Ala His His Gln Val Gln Pro Phe Ala Pro His Gly Pro Gln Asn 
                965                 970                 975     


Ile Ala Ala Leu Ser Leu Val Pro Gly Cys Ser Pro Ser Ile Thr Ser 
            980                 985                 990         


Thr Gly Leu Ser Pro Phe Pro Arg  Lys Asp Asp Pro Thr  Ile Pro 
        995                 1000                 1005         


<210>  133
<211>  634
<212>  PRT
<213>  Homo sapiens

<400>  133

Met Val Arg Leu Val Leu Pro Asn Pro Gly Leu Asp Ala Arg Ile Pro 
1               5                   10                  15      


Ser Leu Ala Glu Leu Glu Thr Ile Glu Gln Glu Glu Ala Ser Ser Arg 
            20                  25                  30          


Pro Lys Trp Asp Asn Lys Ala Gln Tyr Met Leu Thr Cys Leu Gly Phe 
        35                  40                  45              


Cys Val Gly Leu Gly Asn Val Trp Arg Phe Pro Tyr Leu Cys Gln Ser 
    50                  55                  60                  


His Gly Gly Gly Ala Phe Met Ile Pro Phe Leu Ile Leu Leu Val Leu 
65                  70                  75                  80  


Glu Gly Ile Pro Leu Leu Tyr Leu Glu Phe Ala Ile Gly Gln Arg Leu 
                85                  90                  95      


Arg Arg Gly Ser Leu Gly Val Trp Ser Ser Ile His Pro Ala Leu Lys 
            100                 105                 110         


Gly Leu Gly Leu Ala Ser Met Leu Thr Ser Phe Met Val Gly Leu Tyr 
        115                 120                 125             


Tyr Asn Thr Ile Ile Ser Trp Ile Met Trp Tyr Leu Phe Asn Ser Phe 
    130                 135                 140                 


Gln Glu Pro Leu Pro Trp Ser Asp Cys Pro Leu Asn Glu Asn Gln Thr 
145                 150                 155                 160 


Gly Tyr Val Asp Glu Cys Ala Arg Ser Ser Pro Val Asp Tyr Phe Trp 
                165                 170                 175     


Tyr Arg Glu Thr Leu Asn Ile Ser Thr Ser Ile Ser Asp Ser Gly Ser 
            180                 185                 190         


Ile Gln Trp Trp Met Leu Leu Cys Leu Ala Cys Ala Trp Ser Val Leu 
        195                 200                 205             


Tyr Met Cys Thr Ile Arg Gly Ile Glu Thr Thr Gly Lys Ala Val Tyr 
    210                 215                 220                 


Ile Thr Ser Thr Leu Pro Tyr Val Val Leu Thr Ile Phe Leu Ile Arg 
225                 230                 235                 240 


Gly Leu Thr Leu Lys Gly Ala Thr Asn Gly Ile Val Phe Leu Phe Thr 
                245                 250                 255     


Pro Asn Val Thr Glu Leu Ala Gln Pro Asp Thr Trp Leu Asp Ala Gly 
            260                 265                 270         


Ala Gln Val Phe Phe Ser Phe Ser Leu Ala Phe Gly Gly Leu Ile Ser 
        275                 280                 285             


Phe Ser Ser Tyr Asn Ser Val His Asn Asn Cys Glu Lys Asp Ser Val 
    290                 295                 300                 


Ile Val Ser Ile Ile Asn Gly Phe Thr Ser Val Tyr Val Ala Ile Val 
305                 310                 315                 320 


Val Tyr Ser Val Ile Gly Phe Arg Ala Thr Gln Arg Tyr Asp Asp Cys 
                325                 330                 335     


Phe Ser Thr Asn Ile Leu Thr Leu Ile Asn Gly Phe Asp Leu Pro Glu 
            340                 345                 350         


Gly Asn Val Thr Gln Glu Asn Phe Val Asp Met Gln Gln Arg Cys Asn 
        355                 360                 365             


Ala Ser Asp Pro Ala Ala Tyr Ala Gln Leu Val Phe Gln Thr Cys Asp 
    370                 375                 380                 


Ile Asn Ala Phe Leu Ser Glu Ala Val Glu Gly Thr Gly Leu Ala Phe 
385                 390                 395                 400 


Ile Val Phe Thr Glu Ala Ile Thr Lys Met Pro Leu Ser Pro Leu Trp 
                405                 410                 415     


Ser Val Leu Phe Phe Ile Met Leu Phe Cys Leu Gly Leu Ser Ser Met 
            420                 425                 430         


Phe Gly Asn Met Glu Gly Val Val Val Pro Leu Gln Asp Leu Arg Val 
        435                 440                 445             


Ile Pro Pro Lys Trp Pro Lys Glu Val Leu Thr Gly Leu Ile Cys Leu 
    450                 455                 460                 


Gly Thr Phe Leu Ile Gly Phe Ile Phe Thr Leu Asn Ser Gly Gln Tyr 
465                 470                 475                 480 


Trp Leu Ser Leu Leu Asp Ser Tyr Ala Gly Ser Ile Pro Leu Leu Ile 
                485                 490                 495     


Ile Ala Phe Cys Glu Met Phe Ser Val Val Tyr Val Tyr Gly Val Asp 
            500                 505                 510         


Arg Phe Asn Lys Asp Ile Glu Phe Met Ile Gly His Lys Pro Asn Ile 
        515                 520                 525             


Phe Trp Gln Val Thr Trp Arg Val Val Ser Pro Leu Leu Met Leu Ile 
    530                 535                 540                 


Ile Phe Leu Phe Phe Phe Val Val Glu Val Ser Gln Glu Leu Thr Tyr 
545                 550                 555                 560 


Ser Ile Trp Asp Pro Gly Tyr Glu Glu Phe Pro Lys Ser Gln Lys Ile 
                565                 570                 575     


Ser Tyr Pro Asn Trp Val Tyr Val Val Val Val Ile Val Ala Gly Val 
            580                 585                 590         


Pro Ser Leu Thr Ile Pro Gly Tyr Ala Ile Tyr Lys Leu Ile Arg Asn 
        595                 600                 605             


His Cys Gln Lys Pro Gly Asp His Gln Gly Leu Val Ser Thr Leu Ser 
    610                 615                 620                 


Thr Ala Ser Met Asn Gly Asp Leu Lys Tyr 
625                 630                 


<210>  134
<211>  1641
<212>  PRT
<213>  Homo sapiens

<400>  134

Met Thr Glu Ser Ser Met Lys Lys Leu Ala Ser Thr Leu Leu Asp Ala 
1               5                   10                  15      


Ile Thr Asp Lys Asp Pro Leu Val Gln Glu Gln Val Cys Ser Ala Leu 
            20                  25                  30          


Cys Ser Leu Gly Glu Val Arg Pro Val Glu Thr Leu Arg Ala Cys Glu 
        35                  40                  45              


Glu Tyr Leu Arg Gln His Asp Lys Leu Ala His Pro Tyr Arg Ala Ala 
    50                  55                  60                  


Val Leu Arg Ala Met Glu Arg Val Leu Ser Ser Arg Ala Ser Glu Leu 
65                  70                  75                  80  


Asp Lys Asp Thr Ala Ser Thr Ile Ile Leu Leu Ala Ser Ser Glu Met 
                85                  90                  95      


Thr Lys Thr Lys Asp Leu Val Trp Asp Trp Gln Gln Ala Ala Ser Gly 
            100                 105                 110         


Val Leu Val Ala Val Gly Arg Gln Phe Ile Ser Lys Val Met Glu Glu 
        115                 120                 125             


Leu Leu Arg Arg Leu His Pro Gly Thr Leu Pro His Cys Ala Val Leu 
    130                 135                 140                 


His Thr Leu Ala Ser Leu Ser Val Ala Asn Ala Phe Gly Val Val Pro 
145                 150                 155                 160 


Phe Leu Pro Ser Val Leu Ser Ser Leu Leu Pro Val Leu Gly Val Ala 
                165                 170                 175     


Lys Gln Asp Thr Val Arg Val Ala Phe Cys Ser Ala Leu Gln Arg Phe 
            180                 185                 190         


Ser Glu Gly Ala Leu Glu Tyr Leu Ala Asn Leu Asp Arg Ala Pro Asp 
        195                 200                 205             


Pro Thr Val Arg Lys Asp Ala Phe Ala Thr Asp Ile Phe Ser Ala Tyr 
    210                 215                 220                 


Asp Val Leu Phe His Gln Trp Leu Gln Ser Arg Glu Ala Lys Leu Arg 
225                 230                 235                 240 


Leu Ala Val Val Glu Ala Leu Gly Pro Met Ser His Leu Leu Pro Ser 
                245                 250                 255     


Glu Arg Leu Glu Glu Gln Leu Pro Lys Leu Leu Pro Gly Ile Leu Ala 
            260                 265                 270         


Leu Tyr Lys Lys His Ala Glu Thr Phe Tyr Leu Ser Lys Ser Leu Gly 
        275                 280                 285             


Gln Ile Leu Glu Ala Ala Val Ser Val Gly Ser Arg Thr Leu Glu Thr 
    290                 295                 300                 


Gln Leu Asp Ala Leu Leu Ala Ala Leu His Ser Gln Ile Cys Val Pro 
305                 310                 315                 320 


Val Glu Ser Ser Ser Pro Leu Val Met Ser Asn Gln Lys Glu Val Leu 
                325                 330                 335     


Arg Cys Phe Thr Val Leu Ala Cys Ser Ser Pro Asp Arg Leu Leu Ala 
            340                 345                 350         


Phe Leu Leu Pro Arg Leu Asp Thr Ser Asn Glu Arg Thr Arg Val Gly 
        355                 360                 365             


Thr Leu Gln Val Val Arg His Val Ile Asn Ser Ala Ala Ala Gln Met 
    370                 375                 380                 


Glu Asp Lys Lys Pro Phe Ile Leu Ser Ser Met Arg Leu Pro Leu Leu 
385                 390                 395                 400 


Asp Thr Asn Ser Lys Val Lys Arg Ala Val Val Gln Val Ile Ser Ala 
                405                 410                 415     


Met Ala His His Gly Tyr Leu Glu Gln Pro Gly Gly Glu Ala Met Ile 
            420                 425                 430         


Glu Tyr Ile Val Gln Gln Cys Ala Leu Pro Pro Glu Gln Glu Pro Glu 
        435                 440                 445             


Lys Pro Gly Pro Gly Ser Lys Asp Pro Lys Ala Asp Ser Val Arg Ala 
    450                 455                 460                 


Ile Ser Val Arg Thr Leu Tyr Leu Val Ser Thr Thr Val Asp Arg Met 
465                 470                 475                 480 


Ser His Val Leu Trp Pro Tyr Leu Leu Gln Phe Leu Thr Pro Val Arg 
                485                 490                 495     


Phe Thr Gly Ala Leu Thr Pro Leu Cys Arg Ser Leu Val His Leu Ala 
            500                 505                 510         


Gln Lys Arg Gln Glu Ala Gly Ala Asp Ala Phe Leu Ile Gln Tyr Asp 
        515                 520                 525             


Ala His Ala Ser Leu Pro Ser Pro Tyr Ala Val Thr Gly Arg Leu Leu 
    530                 535                 540                 


Val Val Ser Ser Ser Pro Tyr Leu Gly Asp Gly Arg Gly Ala Ala Ala 
545                 550                 555                 560 


Leu Arg Leu Leu Ser Val Leu His Pro Asn Ile His Pro Leu Leu Gly 
                565                 570                 575     


Gln His Trp Glu Thr Thr Val Pro Leu Leu Leu Gly Tyr Leu Asp Glu 
            580                 585                 590         


His Thr Glu Glu Thr Leu Pro Gln Glu Glu Trp Glu Glu Lys Leu Leu 
        595                 600                 605             


Met Phe Leu Arg Asp Thr Leu Ala Ile Ile Ser Asp Asn Ala Trp Ile 
    610                 615                 620                 


Cys Gln Leu Ser Leu Glu Leu Cys Arg Gln Leu Pro Cys Tyr Asp Glu 
625                 630                 635                 640 


Ala Pro Gln Glu Lys Asn Phe Leu Tyr Lys Cys Ile Gly Thr Thr Leu 
                645                 650                 655     


Gly Ala Ala Ser Ser Lys Glu Val Val Arg Lys His Leu Gln Glu Leu 
            660                 665                 670         


Leu Glu Thr Ala Arg Tyr Gln Glu Glu Ala Glu Arg Glu Gly Leu Ala 
        675                 680                 685             


Cys Cys Phe Gly Ile Cys Ala Ile Ser His Leu Glu Asp Thr Leu Ala 
    690                 695                 700                 


Gln Leu Glu Asp Phe Val Arg Ser Glu Val Phe Arg Lys Ser Ile Gly 
705                 710                 715                 720 


Ile Leu Asn Ile Phe Lys Asp Arg Ser Glu Asn Glu Val Glu Lys Val 
                725                 730                 735     


Lys Ser Ala Leu Ile Leu Cys Tyr Gly His Val Ala Ala Arg Ala Pro 
            740                 745                 750         


Arg Glu Leu Val Leu Ala Lys Val Glu Ser Asp Ile Leu Arg Asn Ile 
        755                 760                 765             


Cys Gln His Phe Ser Thr Lys Val Leu Gly Ile Lys Val Glu Thr Lys 
    770                 775                 780                 


Asp Pro Ala Leu Lys Leu Cys Leu Val Gln Ser Val Cys Met Val Ser 
785                 790                 795                 800 


Arg Ala Ile Cys Ser Ser Thr Gln Ala Gly Ser Phe His Phe Thr Arg 
                805                 810                 815     


Lys Ala Glu Leu Val Ala Gln Met Met Glu Phe Ile Arg Ala Glu Pro 
            820                 825                 830         


Pro Asp Ser Leu Arg Thr Pro Ile Arg Lys Lys Ala Met Leu Thr Cys 
        835                 840                 845             


Thr Tyr Leu Val Ser Val Glu Pro Ala Leu Asp Glu Gln Ala Arg Ala 
    850                 855                 860                 


Asp Val Ile His Gly Cys Leu His Ser Ile Met Ala Leu Leu Pro Glu 
865                 870                 875                 880 


Pro Lys Glu Glu Asp Gly Gly Cys Gln Lys Ser Leu Tyr Leu Glu Thr 
                885                 890                 895     


Leu His Ala Leu Glu Asp Leu Leu Thr Ser Leu Leu Gln Arg Asn Met 
            900                 905                 910         


Thr Pro Gln Gly Leu Gln Ile Met Ile Glu His Leu Ser Pro Trp Ile 
        915                 920                 925             


Lys Ser Pro Arg Gly His Glu Arg Ala Arg Ala Leu Gly Leu Ser Ala 
    930                 935                 940                 


Leu Leu Leu Arg Tyr Phe Leu Glu His Leu Arg Val Ser Ala Leu Val 
945                 950                 955                 960 


Pro Phe His Asn Leu Gly Leu Leu Ile Gly Leu Phe Ser Pro Arg Cys 
                965                 970                 975     


Ala Asp Leu Trp Pro Ala Thr Arg Gln Glu Ala Val Asp Cys Val Tyr 
            980                 985                 990         


Ser Leu Leu Tyr Leu Gln Leu Gly  Tyr Glu Gly Phe Ser  Arg Asp Tyr 
        995                 1000                 1005             


Arg Asp  Asp Val Ala Glu Arg  Leu Leu Ser Leu Lys  Asp Gly Leu 
    1010                 1015                 1020             


Val His  Pro Asp Pro Ala Ile  Leu Phe His Thr Cys  His Ser Val 
    1025                 1030                 1035             


Gly Gln  Ile Ile Ala Lys Arg  Leu Pro Pro Asp Gln  Leu Ile Ser 
    1040                 1045                 1050             


Leu Leu  Leu Thr Met Phe Glu  Ala Leu Gly Asp Pro  Glu Lys Asn 
    1055                 1060                 1065             


Cys Ser  Arg Ala Ala Thr Val  Met Ile Asn Cys Leu  Leu Gln Glu 
    1070                 1075                 1080             


Arg Gly  Gly Val Leu Gln Glu  Lys Val Pro Glu Ile  Val Ser Val 
    1085                 1090                 1095             


Leu Arg  Ser Lys Leu Gln Glu  Ala Gln Gly Glu His  Val Leu Pro 
    1100                 1105                 1110             


Ala Ala  Gln His Ser Val Tyr  Leu Leu Ala Thr Gln  His Cys Ala 
    1115                 1120                 1125             


Ala Val  Val Ser Ser Leu Leu  Gly Ser Pro Leu Pro  Leu Asp Ser 
    1130                 1135                 1140             


His Thr  Cys Met Leu Trp Arg  Ala Leu Ala Val Glu  Pro Arg Leu 
    1145                 1150                 1155             


Ala Ala  Gln Val Leu Gly Leu  Leu Leu Glu Lys Met  Ser Arg Asp 
    1160                 1165                 1170             


Val Pro  Phe Lys Glu Ser Arg  Ala Phe Leu Leu Gly  Arg Thr Pro 
    1175                 1180                 1185             


Asp Arg  Val Ala Thr Leu Leu  Pro Leu Ser Ala Thr  Cys Ala Leu 
    1190                 1195                 1200             


Phe Glu  Val Met Ser Thr Pro  Ala Ala Gly Pro Ala  Val Leu Glu 
    1205                 1210                 1215             


Leu Tyr  Pro Gln Leu Phe Val  Val Leu Leu Leu Arg  Val Ser Cys 
    1220                 1225                 1230             


Thr Val  Gly Val Gln Leu Pro  Arg Asn Leu Gln Ala  Gln Glu Arg 
    1235                 1240                 1245             


Arg Gly  Ala Ser Pro Ala Leu  Ala Thr Arg Asn Leu  Glu Pro Cys 
    1250                 1255                 1260             


Ser Ser  Ala Val Asp Thr Leu  Arg Ser Met Leu Leu  Arg Ser Gly 
    1265                 1270                 1275             


Ser Glu  Asp Val Val Gln Arg  Met Asp Leu Glu Gly  Gly Trp Glu 
    1280                 1285                 1290             


Leu Leu  Arg Thr Ser Ala Gly  His Glu Glu Gly Ala  Thr Arg Leu 
    1295                 1300                 1305             


Ala Arg  Ala Met Ala Glu His  Ala Gly Pro Arg Leu  Pro Leu Val 
    1310                 1315                 1320             


Leu Lys  Thr Leu Ala Cys Thr  His Ser Ser Ala Tyr  Glu Asn Gln 
    1325                 1330                 1335             


Arg Val  Thr Thr Thr Ala Phe  Leu Ala Glu Leu Leu  Asn Ser Asn 
    1340                 1345                 1350             


Val Ala  Asn Asp Leu Met Leu  Leu Asp Ser Leu Leu  Glu Ser Leu 
    1355                 1360                 1365             


Ala Ala  Arg Gln Lys Asp Thr  Cys Ala Ser Val Arg  Arg Leu Val 
    1370                 1375                 1380             


Leu Arg  Gly Leu Ala Asn Leu  Ala Ser Gly Cys Pro  Asp Lys Val 
    1385                 1390                 1395             


Arg Thr  His Gly Pro Gln Leu  Leu Thr Ala Met Ile  Gly Gly Leu 
    1400                 1405                 1410             


Asp Asp  Gly Asp Asn Pro His  Ser Pro Val Ala Leu  Glu Ala Met 
    1415                 1420                 1425             


Leu Gly  Leu Ala Arg Leu Val  His Leu Val Glu Ser  Trp Asp Leu 
    1430                 1435                 1440             


Arg Ser  Gly Leu Leu His Val  Ala Ile Arg Ile Arg  Pro Phe Phe 
    1445                 1450                 1455             


Asp Ser  Glu Lys Met Glu Phe  Arg Thr Ala Ser Ile  Arg Leu Phe 
    1460                 1465                 1470             


Gly His  Leu Asn Lys Val Cys  His Gly Asp Cys Glu  Asp Val Phe 
    1475                 1480                 1485             


Leu Asp  Gln Val Val Gly Gly  Leu Ala Pro Leu Leu  Leu His Leu 
    1490                 1495                 1500             


Gln Asp  Pro Gln Ala Thr Val  Ala Ser Ala Cys Arg  Phe Ala Leu 
    1505                 1510                 1515             


Arg Met  Cys Gly Pro Asn Leu  Ala Cys Glu Glu Leu  Ser Ala Ala 
    1520                 1525                 1530             


Phe Gln  Lys His Leu Gln Glu  Gly Arg Ala Leu His  Phe Gly Glu 
    1535                 1540                 1545             


Phe Leu  Asn Thr Thr Cys Lys  His Leu Met His His  Phe Pro Asp 
    1550                 1555                 1560             


Leu Leu  Gly Arg Leu Leu Thr  Thr Cys Leu Phe Tyr  Phe Lys Ser 
    1565                 1570                 1575             


Ser Trp  Glu Asn Val Arg Ala  Ala Ala Pro Leu Phe  Thr Gly Phe 
    1580                 1585                 1590             


Leu Val  Leu His Ser Glu Pro  Arg Gln Gln Pro Gln  Val Asp Leu 
    1595                 1600                 1605             


Asp Gln  Leu Ile Ala Ala Leu  Gln Ile Leu Leu Lys  Asp Pro Ala 
    1610                 1615                 1620             


Pro Glu  Val Arg Thr Arg Ala  Ala Glu Ala Leu Gly  Arg Leu Val 
    1625                 1630                 1635             


Lys Leu  Ala 
    1640     


<210>  135
<211>  438
<212>  PRT
<213>  Homo sapiens

<400>  135

Met Pro Cys Thr Cys Thr Trp Arg Asn Trp Arg Gln Trp Ile Arg Pro 
1               5                   10                  15      


Leu Val Ala Val Ile Tyr Leu Val Ser Ile Val Val Ala Val Pro Leu 
            20                  25                  30          


Cys Val Trp Glu Leu Gln Lys Leu Glu Val Gly Ile His Thr Lys Ala 
        35                  40                  45              


Trp Phe Ile Ala Gly Ile Phe Leu Leu Leu Thr Ile Pro Ile Ser Leu 
    50                  55                  60                  


Trp Val Ile Leu Gln His Leu Val His Tyr Thr Gln Pro Glu Leu Gln 
65                  70                  75                  80  


Lys Pro Ile Ile Arg Ile Leu Trp Met Val Pro Ile Tyr Ser Leu Asp 
                85                  90                  95      


Ser Trp Ile Ala Leu Lys Tyr Pro Gly Ile Ala Ile Tyr Val Asp Thr 
            100                 105                 110         


Cys Arg Glu Cys Tyr Glu Ala Tyr Val Ile Tyr Asn Phe Met Gly Phe 
        115                 120                 125             


Leu Thr Asn Tyr Leu Thr Asn Arg Tyr Pro Asn Leu Val Leu Ile Leu 
    130                 135                 140                 


Glu Ala Lys Asp Gln Gln Lys His Phe Pro Pro Leu Cys Cys Cys Pro 
145                 150                 155                 160 


Pro Trp Ala Met Gly Glu Val Leu Leu Phe Arg Cys Lys Leu Gly Val 
                165                 170                 175     


Leu Gln Tyr Thr Val Val Arg Pro Phe Thr Thr Ile Val Ala Leu Ile 
            180                 185                 190         


Cys Glu Leu Leu Gly Ile Tyr Asp Glu Gly Asn Phe Ser Phe Ser Asn 
        195                 200                 205             


Ala Trp Thr Tyr Leu Val Ile Ile Asn Asn Met Ser Gln Leu Phe Ala 
    210                 215                 220                 


Met Tyr Cys Leu Leu Leu Phe Tyr Lys Val Leu Lys Glu Glu Leu Ser 
225                 230                 235                 240 


Pro Ile Gln Pro Val Gly Lys Phe Leu Cys Val Arg Leu Val Val Phe 
                245                 250                 255     


Val Ser Phe Trp Gln Ala Val Val Ile Ala Leu Leu Val Lys Val Gly 
            260                 265                 270         


Val Ile Ser Glu Lys His Thr Trp Glu Trp Gln Thr Val Glu Ala Val 
        275                 280                 285             


Ala Thr Gly Leu Gln Asp Phe Ile Ile Cys Ile Glu Met Phe Leu Ala 
    290                 295                 300                 


Ala Ile Ala His His Tyr Thr Phe Ser Tyr Lys Pro Tyr Val Gln Glu 
305                 310                 315                 320 


Ala Glu Glu Gly Ser Cys Phe Asp Ser Phe Leu Ala Met Trp Asp Val 
                325                 330                 335     


Ser Asp Ile Arg Asp Asp Ile Ser Glu Gln Val Arg His Val Gly Arg 
            340                 345                 350         


Thr Val Gly Gly His Pro Arg Lys Lys Leu Phe Pro Glu Asp Gln Asp 
        355                 360                 365             


Gln Asn Glu His Thr Ser Leu Leu Ser Ser Ser Ser Gln Asp Ala Ile 
    370                 375                 380                 


Ser Ile Ala Ser Ser Met Pro Pro Ser Pro Met Gly His Tyr Gln Gly 
385                 390                 395                 400 


Phe Gly His Thr Val Thr Pro Gln Thr Thr Pro Thr Thr Ala Lys Ile 
                405                 410                 415     


Ser Asp Glu Ile Leu Ser Asp Thr Ile Gly Glu Lys Lys Glu Pro Ser 
            420                 425                 430         


Asp Lys Ser Val Asp Ser 
        435             


<210>  136
<211>  919
<212>  PRT
<213>  Homo sapiens

<400>  136

Met Thr Gly Tyr Thr Met Leu Arg Asn Gly Gly Ala Gly Asn Gly Gly 
1               5                   10                  15      


Gln Thr Cys Met Leu Arg Trp Ser Asn Arg Ile Arg Leu Thr Trp Leu 
            20                  25                  30          


Ser Phe Thr Leu Phe Val Ile Leu Val Phe Phe Pro Leu Ile Ala His 
        35                  40                  45              


Tyr Tyr Leu Thr Thr Leu Asp Glu Ala Asp Glu Ala Gly Lys Arg Ile 
    50                  55                  60                  


Phe Gly Pro Arg Val Gly Asn Glu Leu Cys Glu Val Lys His Val Leu 
65                  70                  75                  80  


Asp Leu Cys Arg Ile Arg Glu Ser Val Ser Glu Glu Leu Leu Gln Leu 
                85                  90                  95      


Glu Ala Lys Arg Gln Glu Leu Asn Ser Glu Ile Ala Lys Leu Asn Leu 
            100                 105                 110         


Lys Ile Glu Ala Cys Lys Lys Ser Ile Glu Asn Ala Lys Gln Asp Leu 
        115                 120                 125             


Leu Gln Leu Lys Asn Val Ile Ser Gln Thr Glu His Ser Tyr Lys Glu 
    130                 135                 140                 


Leu Met Ala Gln Asn Gln Pro Lys Leu Ser Leu Pro Ile Arg Leu Leu 
145                 150                 155                 160 


Pro Glu Lys Asp Asp Ala Gly Leu Pro Pro Pro Lys Ala Thr Arg Gly 
                165                 170                 175     


Cys Arg Leu His Asn Cys Phe Asp Tyr Ser Arg Cys Pro Leu Thr Ser 
            180                 185                 190         


Gly Phe Pro Val Tyr Val Tyr Asp Ser Asp Gln Phe Val Phe Gly Ser 
        195                 200                 205             


Tyr Leu Asp Pro Leu Val Lys Gln Ala Phe Gln Ala Thr Ala Arg Ala 
    210                 215                 220                 


Asn Val Tyr Val Thr Glu Asn Ala Asp Ile Ala Cys Leu Tyr Val Ile 
225                 230                 235                 240 


Leu Val Gly Glu Met Gln Glu Pro Val Val Leu Arg Pro Ala Glu Leu 
                245                 250                 255     


Glu Lys Gln Leu Tyr Ser Leu Pro His Trp Arg Thr Asp Gly His Asn 
            260                 265                 270         


His Val Ile Ile Asn Leu Ser Arg Lys Ser Asp Thr Gln Asn Leu Leu 
        275                 280                 285             


Tyr Asn Val Ser Thr Gly Arg Ala Met Val Ala Gln Ser Thr Phe Tyr 
    290                 295                 300                 


Thr Val Gln Tyr Arg Pro Gly Phe Asp Leu Val Val Ser Pro Leu Val 
305                 310                 315                 320 


His Ala Met Ser Glu Pro Asn Phe Met Glu Ile Pro Pro Gln Val Pro 
                325                 330                 335     


Val Lys Arg Lys Tyr Leu Phe Thr Phe Gln Gly Glu Lys Ile Glu Ser 
            340                 345                 350         


Leu Arg Ser Ser Leu Gln Glu Ala Arg Ser Phe Glu Glu Glu Met Glu 
        355                 360                 365             


Gly Asp Pro Pro Ala Asp Tyr Asp Asp Arg Ile Ile Ala Thr Leu Lys 
    370                 375                 380                 


Ala Val Gln Asp Ser Lys Leu Asp Gln Val Leu Val Glu Phe Thr Cys 
385                 390                 395                 400 


Lys Asn Gln Pro Lys Pro Ser Leu Pro Thr Glu Trp Ala Leu Cys Gly 
                405                 410                 415     


Glu Arg Glu Asp Arg Leu Glu Leu Leu Lys Leu Ser Thr Phe Ala Leu 
            420                 425                 430         


Ile Ile Thr Pro Gly Asp Pro Arg Leu Val Ile Ser Ser Gly Cys Ala 
        435                 440                 445             


Thr Arg Leu Phe Glu Ala Leu Glu Val Gly Ala Val Pro Val Val Leu 
    450                 455                 460                 


Gly Glu Gln Val Gln Leu Pro Tyr Gln Asp Met Leu Gln Trp Asn Glu 
465                 470                 475                 480 


Ala Ala Leu Val Val Pro Lys Pro Arg Val Thr Glu Val His Phe Leu 
                485                 490                 495     


Leu Arg Ser Leu Ser Asp Ser Asp Leu Leu Ala Met Arg Arg Gln Gly 
            500                 505                 510         


Arg Phe Leu Trp Glu Thr Tyr Phe Ser Thr Ala Asp Ser Ile Phe Asn 
        515                 520                 525             


Thr Val Leu Ala Met Ile Arg Thr Arg Ile Gln Ile Pro Ala Ala Pro 
    530                 535                 540                 


Ile Arg Glu Glu Ala Ala Ala Glu Ile Pro His Arg Ser Gly Lys Ala 
545                 550                 555                 560 


Ala Gly Thr Asp Pro Asn Met Ala Asp Asn Gly Asp Leu Asp Leu Gly 
                565                 570                 575     


Pro Val Glu Thr Glu Pro Pro Tyr Ala Ser Pro Arg Tyr Leu Arg Asn 
            580                 585                 590         


Phe Thr Leu Thr Val Thr Asp Phe Tyr Arg Ser Trp Asn Cys Ala Pro 
        595                 600                 605             


Gly Pro Phe His Leu Phe Pro His Thr Pro Phe Asp Pro Val Leu Pro 
    610                 615                 620                 


Ser Glu Ala Lys Phe Leu Gly Ser Gly Thr Gly Phe Arg Pro Ile Gly 
625                 630                 635                 640 


Gly Gly Ala Gly Gly Ser Gly Lys Glu Phe Gln Ala Ala Leu Gly Gly 
                645                 650                 655     


Asn Val Pro Arg Glu Gln Phe Thr Val Val Met Leu Thr Tyr Glu Arg 
            660                 665                 670         


Glu Glu Val Leu Met Asn Ser Leu Glu Arg Leu Asn Gly Leu Pro Tyr 
        675                 680                 685             


Leu Asn Lys Val Val Val Val Trp Asn Ser Pro Lys Leu Pro Ser Glu 
    690                 695                 700                 


Asp Leu Leu Trp Pro Asp Ile Gly Val Pro Ile Met Val Val Arg Thr 
705                 710                 715                 720 


Glu Lys Asn Ser Leu Asn Asn Arg Phe Leu Pro Trp Asn Glu Ile Glu 
                725                 730                 735     


Thr Glu Ala Ile Leu Ser Ile Asp Asp Asp Ala His Leu Arg His Asp 
            740                 745                 750         


Glu Ile Met Phe Gly Phe Arg Val Trp Arg Glu Ala Arg Asp Arg Ile 
        755                 760                 765             


Val Gly Phe Pro Gly Arg Tyr His Ala Trp Asp Ile Pro His Gln Ser 
    770                 775                 780                 


Trp Leu Tyr Asn Ser Asn Tyr Ser Cys Glu Leu Ser Met Val Leu Thr 
785                 790                 795                 800 


Gly Ala Ala Phe Phe His Lys Tyr Tyr Ala Tyr Leu Tyr Ser Tyr Val 
                805                 810                 815     


Met Pro Gln Ala Ile Arg Asp Met Val Asp Glu Tyr Ile Asn Cys Glu 
            820                 825                 830         


Asp Ile Ala Met Asn Phe Leu Val Ser His Ile Thr Arg Lys Pro Pro 
        835                 840                 845             


Ile Lys Val Thr Ser Arg Trp Thr Phe Arg Cys Pro Gly Cys Pro Gln 
    850                 855                 860                 


Ala Leu Ser His Asp Asp Ser His Phe His Glu Arg His Lys Cys Ile 
865                 870                 875                 880 


Asn Phe Phe Val Lys Val Tyr Gly Tyr Met Pro Leu Leu Tyr Thr Gln 
                885                 890                 895     


Phe Arg Val Asp Ser Val Leu Phe Lys Thr Arg Leu Pro His Asp Lys 
            900                 905                 910         


Thr Lys Cys Phe Lys Phe Ile 
        915                 


<210>  137
<211>  217
<212>  PRT
<213>  Homo sapiens

<400>  137

Met Ala Leu Val Gln Ala Leu Val Pro Arg Glu Arg Glu Pro Lys Leu 
1               5                   10                  15      


Ser Ile Leu Gln Met Asp Arg Gly Asp Pro Gln His Ser Ser His Trp 
            20                  25                  30          


Cys Pro Glu Arg Glu Lys Val Lys Leu Leu Thr Leu Lys Pro Arg Glu 
        35                  40                  45              


Thr Ser Lys Asn Ile Leu Ile Asn Phe Tyr Arg Ala Phe Asn Leu Asp 
    50                  55                  60                  


Lys Asp Val Phe Ile His Gln Ala Asn His Pro Leu Thr Val Pro Ser 
65                  70                  75                  80  


Ser Val Val Met Gly Asp Asn Gly His Thr Leu Ala Glu Asp Asp Lys 
                85                  90                  95      


Arg Pro Cys Phe Arg Val Leu Pro Cys Tyr Leu Glu Arg Val Ser Ser 
            100                 105                 110         


Gly Ile Ser Ile Ser Trp Ile Ser Ala Pro Leu Pro Val Gly Ala Met 
        115                 120                 125             


Lys His Gln Leu Leu Cys Asp Leu Met Asp Leu Ile Thr Leu Ser Phe 
    130                 135                 140                 


Trp Leu Ala Gly Gln Cys Met Ser Leu Lys Ala Thr Asn Met Gln His 
145                 150                 155                 160 


Cys Lys Cys Ser Ile Ala Thr Ser Asp Trp Ala Ile Glu Leu Asp Arg 
                165                 170                 175     


Thr Asp Tyr Lys Thr Leu Pro Ser Glu Tyr Ser Ile Leu Ala Leu Leu 
            180                 185                 190         


Gln Val Phe Ala Gly Lys Asn Cys Met Asp Arg Val Leu Leu His Val 
        195                 200                 205             


Asp Val Asn Tyr Leu Lys Ser Leu Pro 
    210                 215         


<210>  138
<211>  992
<212>  PRT
<213>  Homo sapiens

<400>  138

Met Lys Thr Glu Thr Val Pro Pro Phe Gln Glu Thr Pro Ala Gly Ser 
1               5                   10                  15      


Ser Cys His Leu Asn Asn Leu Leu Ser Ser Arg Lys Leu Met Ala Val 
            20                  25                  30          


Gly Val Leu Leu Gly Trp Leu Leu Val Ile His Leu Leu Val Asn Val 
        35                  40                  45              


Trp Leu Leu Cys Leu Leu Ser Ala Leu Leu Val Val Leu Gly Gly Trp 
    50                  55                  60                  


Leu Gly Ser Ser Leu Ala Gly Val Ala Ser Gly Arg Leu His Leu Glu 
65                  70                  75                  80  


Arg Phe Ile Pro Leu Ala Thr Cys Pro Pro Cys Pro Glu Ala Glu Arg 
                85                  90                  95      


Gln Leu Glu Arg Glu Ile Asn Arg Thr Ile Gln Met Ile Ile Arg Asp 
            100                 105                 110         


Phe Val Leu Ser Trp Tyr Arg Ser Val Ser Gln Glu Pro Ala Phe Glu 
        115                 120                 125             


Glu Glu Met Glu Ala Ala Met Lys Gly Leu Val Gln Glu Leu Arg Arg 
    130                 135                 140                 


Arg Met Ser Val Met Asp Ser His Ala Val Ala Gln Ser Val Leu Thr 
145                 150                 155                 160 


Leu Cys Gly Cys His Leu Gln Ser Tyr Ile Gln Ala Lys Glu Ala Thr 
                165                 170                 175     


Ala Gly Lys Asn Gly Pro Val Glu Pro Ser His Leu Trp Glu Ala Tyr 
            180                 185                 190         


Cys Arg Ala Thr Ala Pro His Pro Ala Val His Ser Pro Ser Ala Glu 
        195                 200                 205             


Val Thr Tyr Thr Arg Gly Val Val Asn Leu Leu Leu Gln Gly Leu Val 
    210                 215                 220                 


Pro Lys Pro His Leu Glu Thr Arg Thr Gly Arg His Val Val Val Glu 
225                 230                 235                 240 


Leu Ile Thr Cys Asn Val Ile Leu Pro Leu Ile Ser Arg Leu Ser Asp 
                245                 250                 255     


Pro Asp Trp Ile His Leu Val Leu Val Gly Ile Phe Ser Lys Ala Arg 
            260                 265                 270         


Asp Pro Ala Pro Cys Pro Ala Ser Ala Pro Glu Gln Pro Ser Val Pro 
        275                 280                 285             


Thr Ser Leu Pro Leu Ile Ala Glu Val Glu Gln Leu Pro Glu Gly Arg 
    290                 295                 300                 


Ala Ser Pro Val Ala Ala Pro Val Phe Leu Ser Tyr Ser Glu Pro Glu 
305                 310                 315                 320 


Gly Ser Ala Gly Pro Ser Pro Glu Val Glu Glu Gly His Glu Ala Val 
                325                 330                 335     


Glu Gly Asp Leu Gly Gly Met Cys Glu Glu Arg Lys Val Gly Asn Asn 
            340                 345                 350         


Ser Ser His Phe Leu Gln Pro Asn Leu Arg Gly Pro Leu Phe Leu Cys 
        355                 360                 365             


Glu Asp Ser Glu Leu Glu Ser Pro Leu Ser Glu Leu Gly Lys Glu Thr 
    370                 375                 380                 


Ile Met Leu Met Thr Pro Gly Ser Phe Leu Ser Asp Arg Ile Gln Asp 
385                 390                 395                 400 


Ala Leu Cys Ala Leu Glu Ser Ser Gln Ala Leu Glu Pro Lys Asp Gly 
                405                 410                 415     


Glu Ala Ser Glu Gly Ala Glu Ala Glu Glu Gly Pro Gly Thr Glu Thr 
            420                 425                 430         


Glu Thr Gly Leu Pro Val Ser Thr Leu Asn Ser Cys Pro Glu Ile His 
        435                 440                 445             


Ile Asp Thr Ala Asp Lys Glu Ile Glu Gln Gly Asp Val Thr Ala Ser 
    450                 455                 460                 


Val Thr Ala Leu Leu Glu Gly Pro Glu Lys Thr Cys Pro Ser Arg Pro 
465                 470                 475                 480 


Ser Cys Leu Glu Lys Asp Leu Thr Asn Asp Val Ser Ser Leu Asp Pro 
                485                 490                 495     


Thr Leu Pro Pro Val Leu Leu Ser Ser Ser Pro Pro Gly Pro Leu Ser 
            500                 505                 510         


Ser Ala Thr Phe Ser Phe Glu Pro Leu Ser Ser Pro Asp Gly Pro Val 
        515                 520                 525             


Ile Ile Gln Asn Leu Arg Ile Thr Gly Thr Ile Thr Ala Arg Glu His 
    530                 535                 540                 


Ser Gly Thr Gly Phe His Pro Tyr Thr Leu Tyr Thr Val Lys Tyr Glu 
545                 550                 555                 560 


Thr Ala Leu Asp Gly Glu Asn Ser Ser Gly Leu Gln Gln Leu Ala Tyr 
                565                 570                 575     


His Thr Val Asn Arg Arg Tyr Arg Glu Phe Leu Asn Leu Gln Thr Arg 
            580                 585                 590         


Leu Glu Glu Lys Pro Asp Leu Arg Lys Phe Ile Lys Asn Val Lys Gly 
        595                 600                 605             


Pro Lys Lys Leu Phe Pro Asp Leu Pro Phe Gly Asn Met Asp Ser Asp 
    610                 615                 620                 


Arg Val Glu Ala Arg Lys Ser Leu Leu Glu Ser Phe Leu Lys Gln Leu 
625                 630                 635                 640 


Cys Ala Ile Pro Glu Ile Ala Asn Ser Glu Glu Val Gln Glu Phe Leu 
                645                 650                 655     


Ala Leu Asn Thr Asp Ala Arg Ile Ala Phe Val Lys Lys Pro Phe Met 
            660                 665                 670         


Val Ser Arg Ile Asp Lys Met Val Val Ser Ala Ile Val Asp Thr Leu 
        675                 680                 685             


Lys Thr Ala Phe Pro Arg Ser Glu Pro Gln Ser Pro Thr Glu Glu Leu 
    690                 695                 700                 


Ser Glu Ala Glu Thr Glu Ser Lys Pro Gln Thr Glu Gly Lys Lys Ala 
705                 710                 715                 720 


Ser Lys Ser Arg Leu Arg Phe Ser Ser Ser Lys Ile Ser Pro Ala Leu 
                725                 730                 735     


Ser Val Thr Glu Ala Gln Asp Lys Ile Leu Tyr Cys Leu Gln Glu Gly 
            740                 745                 750         


Ser Val Glu Ser Glu Thr Leu Ser Met Ser Ala Met Glu Ser Phe Ile 
        755                 760                 765             


Glu Lys Gln Thr Lys Leu Leu Glu Met Gln Pro Thr Lys Ala Pro Glu 
    770                 775                 780                 


Lys Asp Pro Glu Gln Pro Pro Lys Gly Arg Val Asp Ser Cys Val Ser 
785                 790                 795                 800 


Asp Ala Ala Val Pro Ala Gln Asp Pro Ser Asn Ser Asp Pro Gly Thr 
                805                 810                 815     


Glu Thr Glu Leu Ala Asp Thr Ala Leu Asp Leu Leu Leu Leu Leu Leu 
            820                 825                 830         


Thr Glu Gln Trp Lys Trp Leu Cys Thr Glu Asn Met Gln Lys Phe Leu 
        835                 840                 845             


Arg Leu Ile Phe Gly Thr Leu Val Gln Arg Trp Leu Glu Val Gln Val 
    850                 855                 860                 


Ala Asn Leu Thr Ser Pro Gln Arg Trp Val Gln Tyr Leu Arg Leu Leu 
865                 870                 875                 880 


Gln Glu Ser Ile Trp Pro Gly Gly Val Leu Pro Lys Phe Pro Arg Pro 
                885                 890                 895     


Val Arg Thr Gln Glu Gln Lys Leu Ala Ala Glu Lys Gln Ala Leu Gln 
            900                 905                 910         


Ser Leu Met Gly Val Leu Pro Asp Leu Val Val Glu Ile Leu Gly Val 
        915                 920                 925             


Asn Lys Cys Arg Leu Ser Trp Gly Leu Val Leu Glu Ser Leu Gln Gln 
    930                 935                 940                 


Pro Leu Ile Asn Arg His Leu Ile Tyr Cys Leu Gly Asp Ile Ile Leu 
945                 950                 955                 960 


Glu Phe Leu Asp Leu Ser Ala Ser Val Glu Glu Ser Ala Ala Thr Thr 
                965                 970                 975     


Ser Ala Ser Asp Thr Pro Gly Asn Ser Lys Arg Met Gly Val Ser Ser 
            980                 985                 990         


<210>  139
<211>  609
<212>  PRT
<213>  Homo sapiens

<400>  139

Met Ser Gly Trp Glu Ser Tyr Tyr Lys Thr Glu Gly Asp Glu Glu Ala 
1               5                   10                  15      


Glu Glu Glu Gln Glu Glu Asn Leu Glu Ala Ser Gly Asp Tyr Lys Tyr 
            20                  25                  30          


Ser Gly Arg Asp Ser Leu Ile Phe Leu Val Asp Ala Ser Lys Ala Met 
        35                  40                  45              


Phe Glu Ser Gln Ser Glu Asp Glu Leu Thr Pro Phe Asp Met Ser Ile 
    50                  55                  60                  


Gln Cys Ile Gln Ser Val Tyr Ile Ser Lys Ile Ile Ser Ser Asp Arg 
65                  70                  75                  80  


Asp Leu Leu Ala Val Val Phe Tyr Gly Thr Glu Lys Asp Lys Asn Ser 
                85                  90                  95      


Val Asn Phe Lys Asn Ile Tyr Val Leu Gln Glu Leu Asp Asn Pro Gly 
            100                 105                 110         


Ala Lys Arg Ile Leu Glu Leu Asp Gln Phe Lys Gly Gln Gln Gly Gln 
        115                 120                 125             


Lys Arg Phe Gln Asp Met Met Gly His Gly Ser Asp Tyr Ser Leu Ser 
    130                 135                 140                 


Glu Val Leu Trp Val Cys Ala Asn Leu Phe Ser Asp Val Gln Phe Lys 
145                 150                 155                 160 


Met Ser His Lys Arg Ile Met Leu Phe Thr Asn Glu Asp Asn Pro His 
                165                 170                 175     


Gly Asn Asp Ser Ala Lys Ala Ser Arg Ala Arg Thr Lys Ala Gly Asp 
            180                 185                 190         


Leu Arg Asp Thr Gly Ile Phe Leu Asp Leu Met His Leu Lys Lys Pro 
        195                 200                 205             


Gly Gly Phe Asp Ile Ser Leu Phe Tyr Arg Asp Ile Ile Ser Ile Ala 
    210                 215                 220                 


Glu Asp Glu Asp Leu Arg Val His Phe Glu Glu Ser Ser Lys Leu Glu 
225                 230                 235                 240 


Asp Leu Leu Arg Lys Val Arg Ala Lys Glu Thr Arg Lys Arg Ala Leu 
                245                 250                 255     


Ser Arg Leu Lys Leu Lys Leu Asn Lys Asp Ile Val Ile Ser Val Gly 
            260                 265                 270         


Ile Tyr Asn Leu Val Gln Lys Ala Leu Lys Pro Pro Pro Ile Lys Leu 
        275                 280                 285             


Tyr Arg Glu Thr Asn Glu Pro Val Lys Thr Lys Thr Arg Thr Phe Asn 
    290                 295                 300                 


Thr Ser Thr Gly Gly Leu Leu Leu Pro Ser Asp Thr Lys Arg Ser Gln 
305                 310                 315                 320 


Ile Tyr Gly Ser Arg Gln Ile Ile Leu Glu Lys Glu Glu Thr Glu Glu 
                325                 330                 335     


Leu Lys Arg Phe Asp Asp Pro Gly Leu Met Leu Met Gly Phe Lys Pro 
            340                 345                 350         


Leu Val Leu Leu Lys Lys His His Tyr Leu Arg Pro Ser Leu Phe Val 
        355                 360                 365             


Tyr Pro Glu Glu Ser Leu Val Ile Gly Ser Ser Thr Leu Phe Ser Ala 
    370                 375                 380                 


Leu Leu Ile Lys Cys Leu Glu Lys Glu Val Ala Ala Leu Cys Arg Tyr 
385                 390                 395                 400 


Thr Pro Arg Arg Asn Ile Pro Pro Tyr Phe Val Ala Leu Val Pro Gln 
                405                 410                 415     


Glu Glu Glu Leu Asp Asp Gln Lys Ile Gln Val Thr Pro Pro Gly Phe 
            420                 425                 430         


Gln Leu Val Phe Leu Pro Phe Ala Asp Asp Lys Arg Lys Met Pro Phe 
        435                 440                 445             


Thr Glu Lys Ile Met Ala Thr Pro Glu Gln Val Gly Lys Met Lys Ala 
    450                 455                 460                 


Ile Val Glu Lys Leu Arg Phe Thr Tyr Arg Ser Asp Ser Phe Glu Asn 
465                 470                 475                 480 


Pro Val Leu Gln Gln His Phe Arg Asn Leu Glu Ala Leu Ala Leu Asp 
                485                 490                 495     


Leu Met Glu Pro Glu Gln Ala Val Asp Leu Thr Leu Pro Lys Val Glu 
            500                 505                 510         


Ala Met Asn Lys Arg Leu Gly Ser Leu Val Asp Glu Phe Lys Glu Leu 
        515                 520                 525             


Val Tyr Pro Pro Asp Tyr Asn Pro Glu Gly Lys Val Thr Lys Arg Lys 
    530                 535                 540                 


His Asp Asn Glu Gly Ser Gly Ser Lys Arg Pro Lys Val Glu Tyr Ser 
545                 550                 555                 560 


Glu Glu Glu Leu Lys Thr His Ile Ser Lys Gly Thr Leu Gly Lys Phe 
                565                 570                 575     


Thr Val Pro Met Leu Lys Glu Ala Cys Arg Ala Tyr Gly Leu Lys Ser 
            580                 585                 590         


Gly Leu Lys Lys Gln Glu Leu Leu Glu Ala Leu Thr Lys His Phe Gln 
        595                 600                 605             


Asp 
    


<210>  140
<211>  2095
<212>  PRT
<213>  Homo sapiens

<400>  140

Met Ala Asp Ala Asp Ile Leu Ser Glu Thr Phe Gln Leu Leu Ile Asp 
1               5                   10                  15      


Ser Ala Lys Asp Phe Ser Lys Arg Leu Trp Gly Leu Val Pro Phe Gly 
            20                  25                  30          


Leu Tyr Leu Pro Ala Pro Pro Leu Tyr Cys Pro Gln Pro Ala Ile Leu 
        35                  40                  45              


Ser Glu Glu Asp Gly Asp Asp Leu Leu Leu Lys Ala Glu Lys Asn Asn 
    50                  55                  60                  


Arg Gln Lys Val Ser Gly Ile Leu Gln Arg Val Leu Leu Leu Phe Arg 
65                  70                  75                  80  


Ala Ala Gln Cys Ser Phe Pro Val Ala Gln Trp Tyr Ile Leu Gln Leu 
                85                  90                  95      


Arg Trp Ala Arg Lys Val Met Gln Lys Ile Arg Met Lys Gly Ser Leu 
            100                 105                 110         


Pro Ser Leu Ser Pro Phe Pro Gln Ser Leu Leu Asn Tyr Cys Lys Gly 
        115                 120                 125             


Gly Ile Ala Phe Phe Arg Pro Gly Ala Ala Gly Asp His Lys Leu Asp 
    130                 135                 140                 


Glu Val Ser Ile Arg Ala Ile Gly Cys Phe Arg Glu Leu Cys Ala Leu 
145                 150                 155                 160 


Cys Trp Met Leu His Val Arg Asp Lys Leu Ser Tyr Ser Cys Arg Gln 
                165                 170                 175     


Tyr Gln Lys Ala Arg Glu Asn Val Lys Gly Glu Lys Asp Leu Glu Val 
            180                 185                 190         


Glu Phe Asp Ser Cys Met Ile Glu His Cys Leu Ser Ala Val Glu Trp 
        195                 200                 205             


Ala Tyr Arg Met Leu Pro Phe Ser Arg Phe Phe Asn Met Glu Glu Leu 
    210                 215                 220                 


Ile Gln Asp Ile Ile Leu Ser Leu Ile Gly Glu Leu Pro Pro Ile Arg 
225                 230                 235                 240 


Lys Val Ala Glu Ile Phe Val Lys Ala Phe Pro Tyr Pro Glu Asp Val 
                245                 250                 255     


Arg Val Pro Leu Arg Asp Lys Tyr His Ser Leu His Gln Arg Leu Arg 
            260                 265                 270         


His Cys Val Val Lys Gly Pro Gln Thr Glu Glu Met Met Ser Val Val 
        275                 280                 285             


Met His Ser Ile Gln Lys Val Arg Val Lys Ala Leu Lys Arg Val Arg 
    290                 295                 300                 


Arg Asn Ile Gly Ser Phe Glu Val Asn Ile Trp Glu Pro Ile Glu Glu 
305                 310                 315                 320 


Glu Lys Pro Asp Glu Ala Pro Gly Val Asp Arg Tyr Ser Leu Gly Thr 
                325                 330                 335     


Ser Leu Ser Arg Ser Thr Leu Thr Glu Leu Gly Asp Ser Val Val His 
            340                 345                 350         


Ser Asp Ala Asp Thr Phe Ser Glu Ala Leu Ser Val Glu Glu Lys Ser 
        355                 360                 365             


Arg Ile Asn Ile Tyr Gln Arg Asn Ala Pro Asn His Met Glu Leu Thr 
    370                 375                 380                 


Ser Ile His Lys Pro Thr Asp Lys Arg Lys Met Cys Asn Gln Lys Glu 
385                 390                 395                 400 


Asn Pro Thr Lys Lys Glu Asp His Glu Lys Leu Ser Gln Asn Thr Leu 
                405                 410                 415     


Pro Val Ile Gly Val Trp Glu Phe Glu Arg Asp Asp Asp Glu Tyr Ile 
            420                 425                 430         


Lys Phe Leu Asp Leu Phe Leu Ser Tyr Ile Leu Glu Arg Asp Leu Pro 
        435                 440                 445             


Tyr Ser Arg Asp Ala Asp Ile Pro Phe Leu Thr Ser Phe Ser Gly Lys 
    450                 455                 460                 


Leu Arg Glu His Glu Leu Asn Ser Leu Leu Phe Asp Val His Thr Thr 
465                 470                 475                 480 


Leu Lys Arg His Gln Ser Lys Thr Lys Ser Gln Asn Val Phe Arg Ala 
                485                 490                 495     


Gly Ser Cys Phe Val Val Ala Pro Glu Ser Tyr Glu Ser Glu Lys Ser 
            500                 505                 510         


Ser Ser Leu Asn Asp Glu Tyr Gly Met His Leu Glu Asn Gln Lys Leu 
        515                 520                 525             


Ser Ser Ser Val Leu Val Asn Gln Gly Ile Lys Pro Phe Leu Gln Tyr 
    530                 535                 540                 


Pro Ser Asn Glu Val Asn Lys Asn Glu Gly Met Ser Gly Leu Phe Gly 
545                 550                 555                 560 


Leu Lys Gln Arg Ser Ile Tyr Lys Ile Gln Asp Asp Thr Arg Glu Lys 
                565                 570                 575     


Cys Leu Ile Gln Arg Ser Ser Asn His Ile Phe Trp Thr Pro Lys Ser 
            580                 585                 590         


Ile Lys Thr Arg Arg Cys Ile Phe Lys Ala Ile Gln Cys Asn Asp Ile 
        595                 600                 605             


Asn Pro Gln Glu Asp Leu Pro Leu Ala Leu Asn Thr Phe Gly Ser Ile 
    610                 615                 620                 


Gly Arg Leu Leu Glu Trp Met Ile Arg Trp Ser Asn Arg Arg Leu Leu 
625                 630                 635                 640 


Cys Asp Ser Gly Ile Thr Glu Ser Ser Ser Glu Tyr Ser Pro Val Ile 
                645                 650                 655     


Arg Val Lys Thr Ser Thr Ala Ala Ile Leu Thr Ser Leu Trp Leu Leu 
            660                 665                 670         


Glu Gln Pro Tyr Phe Ala Thr Tyr Lys Ala Lys Asn Ala Ile Ile Lys 
        675                 680                 685             


Met Val Glu Asn Arg Asp Thr Gly Cys Gln Ile Gly Pro Asn Ile Glu 
    690                 695                 700                 


Arg Glu Ser Lys Ser Asp Ala Gly Gly Ser Val Ala Val Ala Thr Pro 
705                 710                 715                 720 


Gly Gly Thr Glu Glu Arg Asn Gly Gln Asn Lys Ser Cys Gln Asn Ile 
                725                 730                 735     


Leu Lys Met Pro Thr Glu Ala Lys Asn Pro Asp Ile Lys Glu Ile Asn 
            740                 745                 750         


Asp Asp Ile Ile Ser Ile Thr His Asn Thr Lys Lys Glu Phe Ile Asp 
        755                 760                 765             


Ile Asp Glu Asn Leu Leu Glu Val Glu Ala Phe Thr Glu Glu Glu Met 
    770                 775                 780                 


Asp Met His Ile Ser Asp Tyr Glu Glu Asp Ile Glu Glu Ser Val Gly 
785                 790                 795                 800 


Gly Phe Arg Ser Pro Ser Leu Ala Ile Cys Met Met Thr Leu Pro Gln 
                805                 810                 815     


Gln Leu Glu Glu Glu Phe Thr Glu Glu Val Gln Cys Gln Arg Glu Glu 
            820                 825                 830         


Pro Leu Glu Thr Ile Met Glu Glu Lys Ser Thr Glu Gln Lys Gly Met 
        835                 840                 845             


Ile Glu Ala Phe Ser His Pro Gly His Thr Thr Pro Gln Ser Met Gln 
    850                 855                 860                 


Val Asp Thr Ser Ser Glu Ile Ser Ser Ala Gln Ile Ser Thr Tyr Lys 
865                 870                 875                 880 


Glu Lys Ser Ser Ser Val Pro Leu Leu Ile Ser Asn Gly Val Asn Val 
                885                 890                 895     


Ala Ser Gln Pro Pro Ala Pro Thr Pro Gln Lys Thr Gln Arg Asn Glu 
            900                 905                 910         


Phe Thr Ala Gln Leu Pro Asp Cys Ser Glu Ser Val Arg Gln Met Leu 
        915                 920                 925             


Gln Asp Glu Met Phe Lys Leu Val Gln Leu Gln Gln Ile Asn Phe Met 
    930                 935                 940                 


Ser Leu Met Gln Ile Val Gly Ser Ser Phe Ala Asn Leu Pro Asp Thr 
945                 950                 955                 960 


Gln Gln Leu Val Gln Gln Ser Gln Ser Val His Leu Gly Glu Ser Gln 
                965                 970                 975     


Glu Ser Asn Leu Arg Gly Cys Gly Asp Val Glu Asp Ser Asn Lys Asn 
            980                 985                 990         


Leu Lys Glu Arg Phe Phe Ile Lys  Pro Gln Ser Met Gly  Glu Asn Ala 
        995                 1000                 1005             


Arg Glu  Pro Arg Lys Asn Ser  Pro His Cys His Glu  Gly Thr Ile 
    1010                 1015                 1020             


Pro Ser  Gly Gln Asn Ser Thr  Gly Asn Val Gln Asn  Val Pro His 
    1025                 1030                 1035             


Gly Ser  Ile Pro Leu Cys Gln  Leu Asn Gly Gln Pro  Arg Lys Lys 
    1040                 1045                 1050             


Gly Pro  Ile Pro Ser Ser Gln  Asn Leu Pro Ser Thr  Ser Phe Tyr 
    1055                 1060                 1065             


Pro Ala  Pro Ala Gly Asn Thr  His Leu Tyr Leu Leu  Ser Thr Pro 
    1070                 1075                 1080             


Ser Val  Val Gln Lys Ala Pro  Arg Leu Ile Pro His  Ala Lys Thr 
    1085                 1090                 1095             


Phe Ser  Pro Gly Asp Gly Phe  Pro Leu Leu Gln Phe  Lys Ser Lys 
    1100                 1105                 1110             


Gln Glu  Phe Gln Pro Leu Phe  Leu His Thr Gly Ser  Ile Pro Gln 
    1115                 1120                 1125             


Val Pro  Phe Arg Pro Leu Pro  Gln Pro Arg Glu Ala  Trp Gly Leu 
    1130                 1135                 1140             


Ser Asp  Ser Phe Gln Pro Ala  Leu Pro Gln Arg Ala  Ala Gln Thr 
    1145                 1150                 1155             


Thr Pro  Ala Ser His Leu Asn  Val Ser Gln Tyr Asn  Thr Glu Ala 
    1160                 1165                 1170             


Arg Lys  Lys Glu Val Glu Gln  Lys Thr Trp Ala Glu  Thr Val Ile 
    1175                 1180                 1185             


Thr Glu  Ile Pro Asn His Val  Asn Leu Asp Gln Tyr  Val Gly Gln 
    1190                 1195                 1200             


Glu Asn  Leu Thr Pro Gln Gln  Asp Ser Ser Val Phe  Ile Lys Pro 
    1205                 1210                 1215             


Glu Lys  Leu Phe Asp Val Lys  Pro Gly Thr Leu Glu  Ile Ser Pro 
    1220                 1225                 1230             


His His  Ser Phe Gly Leu Pro  Leu Leu Tyr Leu Pro  Leu Lys Pro 
    1235                 1240                 1245             


Pro Asn  Met Phe Pro Ser Thr  Ser Arg Ala Ser Ile  Thr Val Pro 
    1250                 1255                 1260             


Ser Thr  Pro Ile Gln Pro Ile  Ala Glu Glu Arg Lys  Tyr Pro Arg 
    1265                 1270                 1275             


Leu Ser  Leu Leu His Ser His  Leu Ser Pro Glu Asn  Arg Cys Lys 
    1280                 1285                 1290             


Lys Thr  Gln Leu Ile Pro Leu  Glu Asn Leu Ile Ala  Phe Lys Gln 
    1295                 1300                 1305             


Ser Gln  Gln Lys Leu Thr His  Asn Leu Phe Glu Gln  Gly Asp Ala 
    1310                 1315                 1320             


Gly His  Leu Gln Leu Leu Lys  Val Lys Ile Glu Pro  Pro Glu Val 
    1325                 1330                 1335             


Arg Gln  Gly Lys Asp Ser Lys  Lys Arg Gln Arg Arg  Arg Ala Glu 
    1340                 1345                 1350             


Lys Glu  Leu Gln Glu Lys Arg  Cys Glu Lys Leu Arg  Arg Lys Pro 
    1355                 1360                 1365             


Asn Val  Thr Phe Arg Pro Glu  Asn Ser Ile Ile Asn  Asn Asp Asp 
    1370                 1375                 1380             


Ser Glu  Ile Ile Lys Lys Pro  Lys Glu Gln Gln Glu  His Cys Gly 
    1385                 1390                 1395             


Ser His  Pro Leu Asp Asp Phe  Asp Val Pro Phe Glu  Met Leu Gln 
    1400                 1405                 1410             


Asp Asp  Asn Thr Ser Ala Gly  Leu His Phe Met Ala  Ser Val Lys 
    1415                 1420                 1425             


Lys Lys  Ala Ile Gly Ser Gln  Asp Ala Ser Thr Asn  Thr Asp Pro 
    1430                 1435                 1440             


Glu His  Glu Pro Leu Thr Ala  Pro Gln Leu Leu Val  Pro Asp Val 
    1445                 1450                 1455             


Tyr Leu  Asn Leu Lys Leu Ser  Ser Glu Met Ser Glu  Lys Pro Trp 
    1460                 1465                 1470             


Ser Pro  Ser Ile Pro His Thr  Val Thr Asn Leu Val  Gly His Thr 
    1475                 1480                 1485             


Tyr Ile  Asn Val Ile Asp Ile  Glu Ala Asn Asp Leu  Leu Gln Glu 
    1490                 1495                 1500             


Leu Pro  Val Arg Glu Glu Pro  Ser Asn Asp Asn Val  Ile Lys Gln 
    1505                 1510                 1515             


Gln Ser  Asp His Leu Ala Val  Pro Ser Ser Ala Glu  Leu His Tyr 
    1520                 1525                 1530             


Met Ala  Ala Ser Val Thr Asn  Ala Val Pro Pro His  Asn Phe Lys 
    1535                 1540                 1545             


Ser Gln  Gly Leu Pro Lys Pro  Glu Phe Arg Phe Lys  Gly Gln Ser 
    1550                 1555                 1560             


Thr Lys  Ser Asp Ser Ala Glu  Asp Tyr Leu Leu Trp  Lys Arg Leu 
    1565                 1570                 1575             


Gln Gly  Val Ser Ala Ala Cys  Pro Ala Pro Ser Ser  Ala Ala His 
    1580                 1585                 1590             


Gln Leu  Glu His Leu Ser Ala  Lys Leu Gln Lys Ile  Asp Glu Gln 
    1595                 1600                 1605             


Leu Leu  Ala Ile Gln Asn Ile  Ala Glu Asn Ile Glu  Gln Asp Phe 
    1610                 1615                 1620             


Pro Lys  Pro Glu Met Leu Asp  Leu His Cys Asp Lys  Ile Gly Pro 
    1625                 1630                 1635             


Val Asp  His Ile Glu Phe Ser  Ser Gly Pro Glu Phe  Lys Lys Thr 
    1640                 1645                 1650             


Leu Ala  Ser Lys Thr Ile Ser  Ile Ser Glu Glu Val  Arg Phe Leu 
    1655                 1660                 1665             


Thr His  Met Asp Glu Glu Asp  Gln Ser Asp Lys Lys  Glu Thr Ser 
    1670                 1675                 1680             


Glu Pro  Glu Phe Ser Ile Thr  Glu Asn Tyr Ser Gly  Gln Lys Thr 
    1685                 1690                 1695             


Cys Val  Phe Pro Thr Ala Asp  Ser Ala Val Ser Leu  Ser Ser Ser 
    1700                 1705                 1710             


Ser Asp  Gln Asn Thr Thr Ser  Pro Gly Met Asn Ser  Ser Asp Glu 
    1715                 1720                 1725             


Leu Cys  Glu Ser Val Ser Val  His Pro Leu Gln Met  Thr Gly Leu 
    1730                 1735                 1740             


Thr Asp  Ile Ala Asp Ile Ile  Asp Asp Leu Ile Ile  Lys Asp Gly 
    1745                 1750                 1755             


Val Ser  Ser Glu Glu Leu Gly  Leu Thr Glu Gln Ala  Met Gly Thr 
    1760                 1765                 1770             


Ser Arg  Ile Gln His Tyr Ser  Gly Arg His Ser Gln  Arg Thr Asp 
    1775                 1780                 1785             


Lys Glu  Arg Arg Glu Ile Gln  Ala Trp Met Lys Arg  Lys Arg Lys 
    1790                 1795                 1800             


Glu Arg  Met Ala Lys Tyr Leu  Asn Glu Leu Ala Glu  Lys Arg Gly 
    1805                 1810                 1815             


Gln Glu  His Asp Pro Phe Cys  Pro Arg Ser Asn Pro  Leu Tyr Met 
    1820                 1825                 1830             


Thr Ser  Arg Glu Ile Arg Leu  Arg Gln Lys Met Lys  His Glu Lys 
    1835                 1840                 1845             


Asp Arg  Leu Leu Leu Ser Glu  His Tyr Ser Arg Arg  Ile Ser Gln 
    1850                 1855                 1860             


Ala Tyr  Gly Leu Met Asn Glu  Leu Leu Ser Glu Ser  Val Gln Leu 
    1865                 1870                 1875             


Pro Thr  Leu Pro Gln Lys Pro  Leu Pro Asn Lys Pro  Ser Pro Thr 
    1880                 1885                 1890             


Gln Ser  Ser Ser Cys Gln His  Cys Pro Ser Pro Arg  Gly Glu Asn 
    1895                 1900                 1905             


Gln His  Gly His Ser Phe Leu  Ile Asn Arg Pro Gly  Lys Val Lys 
    1910                 1915                 1920             


Tyr Met  Ser Lys Pro Ser Tyr  Ile His Lys Arg Lys  Ser Phe Gly 
    1925                 1930                 1935             


Gln Pro  Gln Gly Ser Pro Trp  Pro His Gly Thr Ala  Thr Phe Thr 
    1940                 1945                 1950             


Ile Gln  Lys Lys Ala Gly Gly  Ala Lys Ala Ala Val  Arg Lys Ala 
    1955                 1960                 1965             


Thr Gln  Ser Pro Val Thr Phe  Gln Lys Gly Ser Asn  Ala Pro Cys 
    1970                 1975                 1980             


His Ser  Leu Gln His Thr Lys  Lys His Gly Ser Ala  Gly Leu Ala 
    1985                 1990                 1995             


Pro Gln  Thr Lys Gln Val Cys  Val Glu Tyr Glu Arg  Glu Glu Thr 
    2000                 2005                 2010             


Val Val  Ser Pro Trp Thr Ile  Pro Ser Glu Ile His  Lys Ile Leu 
    2015                 2020                 2025             


His Glu  Ser His Asn Ser Leu  Leu Gln Asp Leu Ser  Pro Thr Glu 
    2030                 2035                 2040             


Glu Glu  Glu Pro Glu His Pro  Phe Gly Val Gly Gly  Val Asp Ser 
    2045                 2050                 2055             


Val Ser  Glu Ser Thr Gly Ser  Ile Leu Ser Lys Leu  Asp Trp Asn 
    2060                 2065                 2070             


Ala Ile  Glu Asp Met Val Ala  Ser Val Glu Asp Gln  Gly Leu Ser 
    2075                 2080                 2085             


Val His  Trp Ala Leu Asp Leu  
    2090                 2095 


<210>  141
<211>  691
<212>  PRT
<213>  Homo sapiens

<400>  141

Met Asp Gln Asn Gln His Leu Asn Lys Thr Ala Glu Ala Gln Pro Ser 
1               5                   10                  15      


Glu Asn Lys Lys Thr Arg Tyr Cys Asn Gly Leu Lys Met Phe Leu Ala 
            20                  25                  30          


Ala Leu Ser Leu Ser Phe Ile Ala Lys Thr Leu Gly Ala Ile Ile Met 
        35                  40                  45              


Lys Ser Ser Ile Ile His Ile Glu Arg Arg Phe Glu Ile Ser Ser Ser 
    50                  55                  60                  


Leu Val Gly Phe Ile Asp Gly Ser Phe Glu Ile Gly Asn Leu Leu Val 
65                  70                  75                  80  


Ile Val Phe Val Ser Tyr Phe Gly Ser Lys Leu His Arg Pro Lys Leu 
                85                  90                  95      


Ile Gly Ile Gly Cys Phe Ile Met Gly Ile Gly Gly Val Leu Thr Ala 
            100                 105                 110         


Leu Pro His Phe Phe Met Gly Tyr Tyr Arg Tyr Ser Lys Glu Thr Asn 
        115                 120                 125             


Ile Asn Ser Ser Glu Asn Ser Thr Ser Thr Leu Ser Thr Cys Leu Ile 
    130                 135                 140                 


Asn Gln Ile Leu Ser Leu Asn Arg Ala Ser Pro Glu Ile Val Gly Lys 
145                 150                 155                 160 


Gly Cys Leu Lys Glu Ser Gly Ser Tyr Met Trp Ile Tyr Val Phe Met 
                165                 170                 175     


Gly Asn Met Leu Arg Gly Ile Gly Glu Thr Pro Ile Val Pro Leu Gly 
            180                 185                 190         


Leu Ser Tyr Ile Asp Asp Phe Ala Lys Glu Gly His Ser Ser Leu Tyr 
        195                 200                 205             


Leu Gly Ile Leu Asn Ala Ile Ala Met Ile Gly Pro Ile Ile Gly Phe 
    210                 215                 220                 


Thr Leu Gly Ser Leu Phe Ser Lys Met Tyr Val Asp Ile Gly Tyr Val 
225                 230                 235                 240 


Asp Leu Ser Thr Ile Arg Ile Thr Pro Thr Asp Ser Arg Trp Val Gly 
                245                 250                 255     


Ala Trp Trp Leu Asn Phe Leu Val Ser Gly Leu Phe Ser Ile Ile Ser 
            260                 265                 270         


Ser Ile Pro Phe Phe Phe Leu Pro Gln Thr Pro Asn Lys Pro Gln Lys 
        275                 280                 285             


Glu Arg Lys Ala Ser Leu Ser Leu His Val Leu Glu Thr Asn Asp Glu 
    290                 295                 300                 


Lys Asp Gln Thr Ala Asn Leu Thr Asn Gln Gly Lys Asn Ile Thr Lys 
305                 310                 315                 320 


Asn Val Thr Gly Phe Phe Gln Ser Phe Lys Ser Ile Leu Thr Asn Pro 
                325                 330                 335     


Leu Tyr Val Met Phe Val Leu Leu Thr Leu Leu Gln Val Ser Ser Tyr 
            340                 345                 350         


Ile Gly Ala Phe Thr Tyr Val Phe Lys Tyr Val Glu Gln Gln Tyr Gly 
        355                 360                 365             


Gln Pro Ser Ser Lys Ala Asn Ile Leu Leu Gly Val Ile Thr Ile Pro 
    370                 375                 380                 


Ile Phe Ala Ser Gly Met Phe Leu Gly Gly Tyr Ile Ile Lys Lys Phe 
385                 390                 395                 400 


Lys Leu Asn Thr Val Gly Ile Ala Lys Phe Ser Cys Phe Thr Ala Val 
                405                 410                 415     


Met Ser Leu Ser Phe Tyr Leu Leu Tyr Phe Phe Ile Leu Cys Glu Asn 
            420                 425                 430         


Lys Ser Val Ala Gly Leu Thr Met Thr Tyr Asp Gly Asn Asn Pro Val 
        435                 440                 445             


Thr Ser His Arg Asp Val Pro Leu Ser Tyr Cys Asn Ser Asp Cys Asn 
    450                 455                 460                 


Cys Asp Glu Ser Gln Trp Glu Pro Val Cys Gly Asn Asn Gly Ile Thr 
465                 470                 475                 480 


Tyr Ile Ser Pro Cys Leu Ala Gly Cys Lys Ser Ser Ser Gly Asn Lys 
                485                 490                 495     


Lys Pro Ile Val Phe Tyr Asn Cys Ser Cys Leu Glu Val Thr Gly Leu 
            500                 505                 510         


Gln Asn Arg Asn Tyr Ser Ala His Leu Gly Glu Cys Pro Arg Asp Asp 
        515                 520                 525             


Ala Cys Thr Arg Lys Phe Tyr Phe Phe Val Ala Ile Gln Val Leu Asn 
    530                 535                 540                 


Leu Phe Phe Ser Ala Leu Gly Gly Thr Ser His Val Met Leu Ile Val 
545                 550                 555                 560 


Lys Ile Val Gln Pro Glu Leu Lys Ser Leu Ala Leu Gly Phe His Ser 
                565                 570                 575     


Met Val Ile Arg Ala Leu Gly Gly Ile Leu Ala Pro Ile Tyr Phe Gly 
            580                 585                 590         


Ala Leu Ile Asp Thr Thr Cys Ile Lys Trp Ser Thr Asn Asn Cys Gly 
        595                 600                 605             


Thr Arg Gly Ser Cys Arg Thr Tyr Asn Ser Thr Ser Phe Ser Arg Val 
    610                 615                 620                 


Tyr Leu Gly Leu Ser Ser Met Leu Arg Val Ser Ser Leu Val Leu Tyr 
625                 630                 635                 640 


Ile Ile Leu Ile Tyr Ala Met Lys Lys Lys Tyr Gln Glu Lys Asp Ile 
                645                 650                 655     


Asn Ala Ser Glu Asn Gly Ser Val Met Asp Glu Ala Asn Leu Glu Ser 
            660                 665                 670         


Leu Asn Lys Asn Lys His Phe Val Pro Ser Ala Gly Ala Asp Ser Glu 
        675                 680                 685             


Thr His Cys 
    690     


<210>  142
<211>  419
<212>  PRT
<213>  Homo sapiens

<400>  142

Met Gly Glu Lys Lys Pro Glu Pro Leu Asp Phe Val Lys Asp Phe Gln 
1               5                   10                  15      


Glu Tyr Leu Thr Gln Gln Thr His His Val Asn Met Ile Ser Gly Ser 
            20                  25                  30          


Val Ser Gly Asp Lys Glu Ala Glu Ala Leu Gln Gly Ala Gly Thr Asp 
        35                  40                  45              


Gly Asp Gln Asn Gly Leu Asp His Pro Ser Val Glu Val Ser Leu Asp 
    50                  55                  60                  


Glu Asn Ser Gly Met Leu Val Asp Gly Phe Glu Arg Thr Phe Asp Gly 
65                  70                  75                  80  


Lys Leu Lys Cys Arg Tyr Cys Asn Tyr Ala Ser Lys Gly Thr Ala Arg 
                85                  90                  95      


Leu Ile Glu His Ile Arg Ile His Thr Gly Glu Lys Pro His Arg Cys 
            100                 105                 110         


His Leu Cys Pro Phe Ala Ser Ala Tyr Glu Arg His Leu Glu Ala His 
        115                 120                 125             


Met Arg Ser His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Leu Cys Ser 
    130                 135                 140                 


Phe Arg Cys Ser Asp Arg Ser Asn Leu Ser His His Arg Arg Arg Lys 
145                 150                 155                 160 


His Lys Met Val Pro Ile Lys Gly Thr Arg Ser Ser Leu Ser Ser Lys 
                165                 170                 175     


Lys Met Trp Gly Val Leu Gln Lys Lys Thr Ser Asn Leu Gly Tyr Ser 
            180                 185                 190         


Arg Arg Ala Leu Ile Asn Leu Ser Pro Pro Ser Met Val Val Gln Lys 
        195                 200                 205             


Pro Asp Tyr Leu Asn Asp Phe Thr His Glu Ile Pro Asn Ile Gln Thr 
    210                 215                 220                 


Asp Ser Tyr Glu Ser Met Ala Lys Thr Thr Pro Thr Gly Gly Leu Pro 
225                 230                 235                 240 


Arg Asp Pro Gln Glu Leu Met Val Asp Asn Pro Leu Asn Gln Leu Ser 
                245                 250                 255     


Thr Leu Ala Gly Gln Leu Ser Ser Leu Pro Pro Glu Asn Gln Asn Pro 
            260                 265                 270         


Ala Ser Pro Asp Val Val Pro Cys Pro Asp Glu Lys Pro Phe Met Ile 
        275                 280                 285             


Gln Gln Pro Ser Thr Gln Ala Val Val Ser Ala Val Ser Ala Ser Ile 
    290                 295                 300                 


Pro Gln Ser Ser Ser Pro Thr Ser Pro Glu Pro Arg Pro Ser His Ser 
305                 310                 315                 320 


Gln Arg Asn Tyr Ser Pro Val Ala Gly Pro Ser Ser Glu Pro Ser Ala 
                325                 330                 335     


His Thr Ser Thr Pro Ser Ile Gly Asn Ser Gln Pro Ser Thr Pro Ala 
            340                 345                 350         


Pro Ala Leu Pro Val Gln Asp Pro Gln Leu Leu His His Cys Gln His 
        355                 360                 365             


Cys Asp Met Tyr Phe Ala Asp Asn Ile Leu Tyr Thr Ile His Met Gly 
    370                 375                 380                 


Cys His Gly Tyr Glu Asn Pro Phe Gln Cys Asn Ile Cys Gly Cys Lys 
385                 390                 395                 400 


Cys Lys Asn Lys Tyr Asp Phe Ala Cys His Phe Ala Arg Gly Gln His 
                405                 410                 415     


Asn Gln His 
            


<210>  143
<211>  330
<212>  PRT
<213>  Homo sapiens

<400>  143

Met Ser Gln Trp His His Pro Arg Ser Gly Trp Gly Arg Arg Arg Asp 
1               5                   10                  15      


Phe Ser Gly Arg Ser Ser Ala Lys Lys Lys Gly Gly Asn His Ile Pro 
            20                  25                  30          


Glu Arg Trp Lys Asp Tyr Leu Pro Val Gly Gln Arg Met Pro Gly Thr 
        35                  40                  45              


Arg Phe Ile Ala Phe Lys Val Pro Leu Gln Lys Ser Phe Glu Lys Lys 
    50                  55                  60                  


Leu Ala Pro Glu Glu Cys Phe Ser Pro Leu Asp Leu Phe Asn Lys Ile 
65                  70                  75                  80  


Arg Glu Gln Asn Glu Glu Leu Gly Leu Ile Ile Asp Leu Thr Tyr Thr 
                85                  90                  95      


Gln Arg Tyr Tyr Lys Pro Glu Asp Leu Pro Glu Thr Val Pro Tyr Leu 
            100                 105                 110         


Lys Ile Phe Thr Val Gly His Gln Val Pro Asp Asp Glu Thr Ile Phe 
        115                 120                 125             


Lys Phe Lys His Ala Val Asn Gly Phe Leu Lys Glu Asn Lys Asp Asn 
    130                 135                 140                 


Asp Lys Leu Ile Gly Val His Cys Thr His Gly Leu Asn Arg Thr Gly 
145                 150                 155                 160 


Tyr Leu Ile Cys Arg Tyr Leu Ile Asp Val Glu Gly Val Arg Pro Asp 
                165                 170                 175     


Asp Ala Ile Glu Leu Phe Asn Arg Cys Arg Gly His Cys Leu Glu Arg 
            180                 185                 190         


Gln Asn Tyr Ile Glu Asp Leu Gln Asn Gly Pro Ile Arg Lys Asn Trp 
        195                 200                 205             


Asn Ser Ser Val Pro Arg Ser Ser Asp Phe Glu Asp Ser Ala His Leu 
    210                 215                 220                 


Met Gln Pro Val His Asn Lys Pro Val Lys Gln Gly Pro Arg Tyr Asn 
225                 230                 235                 240 


Leu His Gln Ile Gln Gly His Ser Ala Pro Arg His Phe His Thr Gln 
                245                 250                 255     


Thr Gln Ser Leu Gln Gln Ser Val Arg Lys Phe Ser Glu Asn Pro His 
            260                 265                 270         


Val Tyr Gln Arg His His Leu Pro Pro Pro Gly Pro Pro Gly Glu Asp 
        275                 280                 285             


Tyr Ser His Arg Arg Tyr Ser Trp Asn Val Lys Pro Asn Ala Ser Arg 
    290                 295                 300                 


Ala Ala Gln Asp Arg Arg Arg Trp Tyr Pro Tyr Asn Tyr Ser Arg Leu 
305                 310                 315                 320 


Ser Tyr Pro Ala Cys Trp Glu Trp Thr Gln 
                325                 330 


<210>  144
<211>  979
<212>  PRT
<213>  Homo sapiens

<400>  144

Met Ala Leu Phe Ala Val Phe Gln Thr Thr Phe Phe Leu Thr Leu Leu 
1               5                   10                  15      


Ser Leu Arg Thr Tyr Gln Ser Glu Val Leu Ala Glu Arg Leu Pro Leu 
            20                  25                  30          


Thr Pro Val Ser Leu Lys Val Ser Thr Asn Ser Thr Arg Gln Ser Leu 
        35                  40                  45              


His Leu Gln Trp Thr Val His Asn Leu Pro Tyr His Gln Glu Leu Lys 
    50                  55                  60                  


Met Val Phe Gln Ile Gln Ile Ser Arg Ile Glu Thr Ser Asn Val Ile 
65                  70                  75                  80  


Trp Val Gly Asn Tyr Ser Thr Thr Val Lys Trp Asn Gln Val Leu His 
                85                  90                  95      


Trp Ser Trp Glu Ser Glu Leu Pro Leu Glu Cys Ala Thr His Phe Val 
            100                 105                 110         


Arg Ile Lys Ser Leu Val Asp Asp Ala Lys Phe Pro Glu Pro Asn Phe 
        115                 120                 125             


Trp Ser Asn Trp Ser Ser Trp Glu Glu Val Ser Val Gln Asp Ser Thr 
    130                 135                 140                 


Gly Gln Asp Ile Leu Phe Val Phe Pro Lys Asp Lys Leu Val Glu Glu 
145                 150                 155                 160 


Gly Thr Asn Val Thr Ile Cys Tyr Val Ser Arg Asn Ile Gln Asn Asn 
                165                 170                 175     


Val Ser Cys Tyr Leu Glu Gly Lys Gln Ile His Gly Glu Gln Leu Asp 
            180                 185                 190         


Pro His Val Thr Ala Phe Asn Leu Asn Ser Val Pro Phe Ile Arg Asn 
        195                 200                 205             


Lys Gly Thr Asn Ile Tyr Cys Glu Ala Ser Gln Gly Asn Val Ser Glu 
    210                 215                 220                 


Gly Met Lys Gly Ile Val Leu Phe Val Ser Lys Val Leu Glu Glu Pro 
225                 230                 235                 240 


Lys Asp Phe Ser Cys Glu Thr Glu Asp Phe Lys Thr Leu His Cys Thr 
                245                 250                 255     


Trp Asp Pro Gly Thr Asp Thr Ala Leu Gly Trp Ser Lys Gln Pro Ser 
            260                 265                 270         


Gln Ser Tyr Thr Leu Phe Glu Ser Phe Ser Gly Glu Lys Lys Leu Cys 
        275                 280                 285             


Thr His Lys Asn Trp Cys Asn Trp Gln Ile Thr Gln Asp Ser Gln Glu 
    290                 295                 300                 


Thr Tyr Asn Phe Thr Leu Ile Ala Glu Asn Tyr Leu Arg Lys Arg Ser 
305                 310                 315                 320 


Val Asn Ile Leu Phe Asn Leu Thr His Arg Val Tyr Leu Met Asn Pro 
                325                 330                 335     


Phe Ser Val Asn Phe Glu Asn Val Asn Ala Thr Asn Ala Ile Met Thr 
            340                 345                 350         


Trp Lys Val His Ser Ile Arg Asn Asn Phe Thr Tyr Leu Cys Gln Ile 
        355                 360                 365             


Glu Leu His Gly Glu Gly Lys Met Met Gln Tyr Asn Val Ser Ile Lys 
    370                 375                 380                 


Val Asn Gly Glu Tyr Phe Leu Ser Glu Leu Glu Pro Ala Thr Glu Tyr 
385                 390                 395                 400 


Met Ala Arg Val Arg Cys Ala Asp Ala Ser His Phe Trp Lys Trp Ser 
                405                 410                 415     


Glu Trp Ser Gly Gln Asn Phe Thr Thr Leu Glu Ala Ala Pro Ser Glu 
            420                 425                 430         


Ala Pro Asp Val Trp Arg Ile Val Ser Leu Glu Pro Gly Asn His Thr 
        435                 440                 445             


Val Thr Leu Phe Trp Lys Pro Leu Ser Lys Leu His Ala Asn Gly Lys 
    450                 455                 460                 


Ile Leu Phe Tyr Asn Val Val Val Glu Asn Leu Asp Lys Pro Ser Ser 
465                 470                 475                 480 


Ser Glu Leu His Ser Ile Pro Ala Pro Ala Asn Ser Thr Lys Leu Ile 
                485                 490                 495     


Leu Asp Arg Cys Ser Tyr Gln Ile Cys Val Ile Ala Asn Asn Ser Val 
            500                 505                 510         


Gly Ala Ser Pro Ala Ser Val Ile Val Ile Ser Ala Asp Pro Glu Asn 
        515                 520                 525             


Lys Glu Val Glu Glu Glu Arg Ile Ala Gly Thr Glu Gly Gly Phe Ser 
    530                 535                 540                 


Leu Ser Trp Lys Pro Gln Pro Gly Asp Val Ile Gly Tyr Val Val Asp 
545                 550                 555                 560 


Trp Cys Asp His Thr Gln Asp Val Leu Gly Asp Phe Gln Trp Lys Asn 
                565                 570                 575     


Val Gly Pro Asn Thr Thr Ser Thr Val Ile Ser Thr Asp Ala Phe Arg 
            580                 585                 590         


Pro Gly Val Arg Tyr Asp Phe Arg Ile Tyr Gly Leu Ser Thr Lys Arg 
        595                 600                 605             


Ile Ala Cys Leu Leu Glu Lys Lys Thr Gly Tyr Ser Gln Glu Leu Ala 
    610                 615                 620                 


Pro Ser Asp Asn Pro His Val Leu Val Asp Thr Leu Thr Ser His Ser 
625                 630                 635                 640 


Phe Thr Leu Ser Trp Lys Asp Tyr Ser Thr Glu Ser Gln Pro Gly Phe 
                645                 650                 655     


Ile Gln Gly Tyr His Val Tyr Leu Lys Ser Lys Ala Arg Gln Cys His 
            660                 665                 670         


Pro Arg Phe Glu Lys Ala Val Leu Ser Asp Gly Ser Glu Cys Cys Lys 
        675                 680                 685             


Tyr Lys Ile Asp Asn Pro Glu Glu Lys Ala Leu Ile Val Asp Asn Leu 
    690                 695                 700                 


Lys Pro Glu Ser Phe Tyr Glu Phe Phe Ile Thr Pro Phe Thr Ser Ala 
705                 710                 715                 720 


Gly Glu Gly Pro Ser Ala Thr Phe Thr Lys Val Thr Thr Pro Asp Glu 
                725                 730                 735     


His Ser Ser Met Leu Ile His Ile Leu Leu Pro Met Val Phe Cys Val 
            740                 745                 750         


Leu Leu Ile Met Val Met Cys Tyr Leu Lys Ser Gln Trp Ile Lys Glu 
        755                 760                 765             


Thr Cys Tyr Pro Asp Ile Pro Asp Pro Tyr Lys Ser Ser Ile Leu Ser 
    770                 775                 780                 


Leu Ile Lys Phe Lys Glu Asn Pro His Leu Ile Ile Met Asn Val Ser 
785                 790                 795                 800 


Asp Cys Ile Pro Asp Ala Ile Glu Val Val Ser Lys Pro Glu Gly Thr 
                805                 810                 815     


Lys Ile Gln Phe Leu Gly Thr Arg Lys Ser Leu Thr Glu Thr Glu Leu 
            820                 825                 830         


Thr Lys Pro Asn Tyr Leu Tyr Leu Leu Pro Thr Glu Lys Asn His Ser 
        835                 840                 845             


Gly Pro Gly Pro Cys Ile Cys Phe Glu Asn Leu Thr Tyr Asn Gln Ala 
    850                 855                 860                 


Ala Ser Asp Ser Gly Ser Cys Gly His Val Pro Val Ser Pro Lys Ala 
865                 870                 875                 880 


Pro Ser Met Leu Gly Leu Met Thr Ser Pro Glu Asn Val Leu Lys Ala 
                885                 890                 895     


Leu Glu Lys Asn Tyr Met Asn Ser Leu Gly Glu Ile Pro Ala Gly Glu 
            900                 905                 910         


Thr Ser Leu Asn Tyr Val Ser Gln Leu Ala Ser Pro Met Phe Gly Asp 
        915                 920                 925             


Lys Asp Ser Leu Pro Thr Asn Pro Val Glu Ala Pro His Cys Ser Glu 
    930                 935                 940                 


Tyr Lys Met Gln Met Ala Val Ser Leu Arg Leu Ala Leu Pro Pro Pro 
945                 950                 955                 960 


Thr Glu Asn Ser Ser Leu Ser Ser Ile Thr Leu Leu Asp Pro Gly Glu 
                965                 970                 975     


His Tyr Cys 
            


<210>  145
<211>  1489
<212>  PRT
<213>  Homo sapiens

<400>  145

Met Gly Asp Ala Ala Asp Pro Arg Glu Met Arg Lys Thr Phe Ile Val 
1               5                   10                  15      


Pro Ala Ile Lys Pro Phe Asp His Tyr Asp Phe Ser Arg Ala Lys Ile 
            20                  25                  30          


Ala Cys Asn Leu Ala Trp Leu Val Ala Lys Ala Phe Gly Thr Glu Asn 
        35                  40                  45              


Val Pro Glu Glu Leu Gln Glu Pro Phe Tyr Thr Asp Gln Tyr Asp Gln 
    50                  55                  60                  


Glu His Ile Lys Pro Pro Val Val Asn Leu Leu Leu Ser Ala Glu Leu 
65                  70                  75                  80  


Tyr Cys Arg Ala Gly Ser Leu Ile Leu Lys Ser Asp Ala Ala Lys Pro 
                85                  90                  95      


Leu Leu Gly His Asp Ala Val Ile Gln Ala Leu Ala Gln Lys Gly Leu 
            100                 105                 110         


Tyr Val Thr Asp Gln Glu Lys Leu Val Thr Glu Arg Asp Leu His Lys 
        115                 120                 125             


Lys Pro Ile Gln Met Ser Ala His Leu Ala Met Ile Asp Thr Leu Met 
    130                 135                 140                 


Met Ala Tyr Thr Val Glu Met Val Ser Ile Glu Lys Val Ile Ala Cys 
145                 150                 155                 160 


Ala Gln Gln Tyr Ser Ala Phe Phe Gln Ala Thr Asp Leu Pro Tyr Asp 
                165                 170                 175     


Ile Glu Asp Ala Val Met Tyr Trp Ile Asn Lys Val Asn Glu His Leu 
            180                 185                 190         


Lys Asp Ile Met Glu Gln Glu Gln Lys Leu Lys Glu His His Thr Val 
        195                 200                 205             


Glu Ala Pro Gly Gly Gln Lys Ser Pro Ser Lys Trp Phe Trp Lys Leu 
    210                 215                 220                 


Val Pro Ala Arg Tyr Arg Lys Glu Gln Thr Leu Leu Lys Gln Leu Pro 
225                 230                 235                 240 


Cys Ile Pro Leu Val Glu Asn Leu Leu Lys Asp Gly Thr Asp Gly Cys 
                245                 250                 255     


Ala Leu Ala Ala Leu Ile His Phe Tyr Cys Pro Asp Val Val Arg Leu 
            260                 265                 270         


Glu Asp Ile Cys Leu Lys Glu Thr Met Ser Leu Ala Asp Ser Leu Tyr 
        275                 280                 285             


Asn Leu Gln Leu Ile Gln Glu Phe Cys Gln Glu Tyr Leu Asn Gln Cys 
    290                 295                 300                 


Cys His Phe Thr Leu Glu Asp Met Leu Tyr Ala Ala Ser Ser Ile Lys 
305                 310                 315                 320 


Ser Asn Tyr Leu Val Phe Met Ala Glu Leu Phe Trp Trp Phe Glu Val 
                325                 330                 335     


Val Lys Pro Ser Phe Val Gln Pro Arg Val Val Arg Pro Gln Gly Ala 
            340                 345                 350         


Glu Pro Val Lys Asp Met Pro Ser Ile Pro Val Leu Asn Ala Ala Lys 
        355                 360                 365             


Arg Asn Val Leu Asp Ser Ser Ser Asp Phe Pro Ser Ser Gly Glu Gly 
    370                 375                 380                 


Ala Thr Phe Thr Gln Ser His His His Leu Pro Ser Arg Tyr Ser Arg 
385                 390                 395                 400 


Pro Gln Ala His Ser Ser Ala Ser Gly Gly Ile Arg Arg Ser Ser Ser 
                405                 410                 415     


Met Ser Tyr Val Asp Gly Phe Ile Gly Thr Trp Pro Lys Glu Lys Arg 
            420                 425                 430         


Ser Ser Val His Gly Val Ser Phe Asp Ile Ser Phe Asp Lys Glu Asp 
        435                 440                 445             


Ser Val Gln Arg Ser Thr Pro Asn Arg Gly Ile Thr Arg Ser Ile Ser 
    450                 455                 460                 


Asn Glu Gly Leu Thr Leu Asn Asn Ser His Val Ser Lys His Ile Arg 
465                 470                 475                 480 


Lys Asn Leu Ser Phe Lys Pro Ile Asn Gly Glu Glu Glu Ala Glu Ser 
                485                 490                 495     


Ile Glu Glu Glu Leu Asn Ile Asp Ser His Ser Asp Leu Lys Ser Cys 
            500                 505                 510         


Val Pro Leu Asn Thr Asn Glu Leu Asn Ser Asn Glu Asn Ile His Tyr 
        515                 520                 525             


Lys Leu Pro Asn Gly Ala Leu Gln Asn Arg Ile Leu Leu Asp Glu Phe 
    530                 535                 540                 


Gly Asn Gln Ile Glu Thr Pro Ser Ile Glu Glu Ala Leu Gln Ile Ile 
545                 550                 555                 560 


His Asp Thr Glu Lys Ser Pro His Thr Pro Gln Pro Asp Gln Ile Ala 
                565                 570                 575     


Asn Gly Phe Phe Leu His Ser Gln Glu Met Ser Ile Leu Asn Ser Asn 
            580                 585                 590         


Ile Lys Leu Asn Gln Ser Ser Pro Asp Asn Val Thr Asp Thr Lys Gly 
        595                 600                 605             


Ala Leu Ser Pro Ile Thr Asp Asn Thr Glu Val Asp Thr Gly Ile His 
    610                 615                 620                 


Val Pro Ser Glu Asp Ile Pro Glu Thr Met Asp Glu Asp Ser Ser Leu 
625                 630                 635                 640 


Arg Asp Tyr Thr Val Ser Leu Asp Ser Asp Met Asp Asp Ala Ser Lys 
                645                 650                 655     


Phe Leu Gln Asp Tyr Asp Ile Arg Thr Gly Asn Thr Arg Glu Ala Leu 
            660                 665                 670         


Ser Pro Cys Pro Ser Thr Val Ser Thr Lys Ser Gln Pro Gly Ser Ser 
        675                 680                 685             


Ala Ser Ser Ser Ser Gly Val Lys Met Thr Ser Phe Ala Glu Gln Lys 
    690                 695                 700                 


Phe Arg Lys Leu Asn His Thr Asp Gly Lys Ser Ser Gly Ser Ser Ser 
705                 710                 715                 720 


Gln Lys Thr Thr Pro Glu Gly Ser Glu Leu Asn Ile Pro His Val Val 
                725                 730                 735     


Ala Trp Ala Gln Ile Pro Glu Glu Thr Gly Leu Pro Gln Gly Arg Asp 
            740                 745                 750         


Thr Thr Gln Leu Leu Ala Ser Glu Met Val His Leu Arg Met Lys Leu 
        755                 760                 765             


Glu Glu Lys Arg Arg Ala Ile Glu Ala Gln Lys Lys Lys Met Glu Ala 
    770                 775                 780                 


Ala Phe Thr Lys Gln Arg Gln Lys Met Gly Arg Thr Ala Phe Leu Thr 
785                 790                 795                 800 


Val Val Lys Lys Lys Gly Asp Gly Ile Ser Pro Leu Arg Glu Glu Ala 
                805                 810                 815     


Ala Gly Ala Glu Asp Glu Lys Val Tyr Thr Asp Arg Ala Lys Glu Lys 
            820                 825                 830         


Glu Ser Gln Lys Thr Asp Gly Gln Arg Ser Lys Ser Leu Ala Asp Ile 
        835                 840                 845             


Lys Glu Ser Met Glu Asn Pro Gln Ala Lys Trp Leu Lys Ser Pro Thr 
    850                 855                 860                 


Thr Pro Ile Asp Pro Glu Lys Gln Trp Asn Leu Ala Ser Pro Ser Glu 
865                 870                 875                 880 


Glu Thr Leu Asn Glu Gly Glu Ile Leu Glu Tyr Thr Lys Ser Ile Glu 
                885                 890                 895     


Lys Leu Asn Ser Ser Leu His Phe Leu Gln Gln Glu Met Gln Arg Leu 
            900                 905                 910         


Ser Leu Gln Gln Glu Met Leu Met Gln Met Arg Glu Gln Gln Ser Trp 
        915                 920                 925             


Val Ile Ser Pro Pro Gln Pro Ser Pro Gln Lys Gln Ile Arg Asp Phe 
    930                 935                 940                 


Lys Pro Ser Lys Gln Ala Gly Leu Ser Ser Ala Ile Ala Pro Phe Ser 
945                 950                 955                 960 


Ser Asp Ser Pro Arg Pro Thr His Pro Ser Pro Gln Ser Ser Asn Arg 
                965                 970                 975     


Lys Ser Ala Ser Phe Ser Val Lys Ser Gln Arg Thr Pro Arg Pro Asn 
            980                 985                 990         


Glu Leu Lys Ile Thr Pro Leu Asn  Arg Thr Leu Thr Pro  Pro Arg Ser 
        995                 1000                 1005             


Val Asp  Ser Leu Pro Arg Leu  Arg Arg Phe Ser Pro  Ser Gln Val 
    1010                 1015                 1020             


Pro Ile  Gln Thr Pro Ser Phe  Val Cys Phe Gly Asp  Asp Gly Glu 
    1025                 1030                 1035             


Pro Gln  Leu Lys Glu Ser Lys  Pro Lys Glu Glu Val  Lys Lys Glu 
    1040                 1045                 1050             


Glu Leu  Glu Ser Lys Gly Thr  Leu Glu Gln Arg Gly  His Asn Pro 
    1055                 1060                 1065             


Glu Glu  Lys Glu Ile Lys Pro  Phe Glu Ser Thr Val  Ser Glu Val 
    1070                 1075                 1080             


Leu Ser  Leu Pro Val Thr Glu  Thr Val Cys Leu Thr  Pro Asn Glu 
    1085                 1090                 1095             


Asp Gln  Leu Asn Gln Pro Thr  Glu Pro Pro Pro Lys  Pro Val Phe 
    1100                 1105                 1110             


Pro Pro  Thr Ala Pro Lys Asn  Val Asn Leu Ile Glu  Val Ser Leu 
    1115                 1120                 1125             


Ser Asp  Leu Lys Pro Pro Glu  Lys Ala Asp Val Pro  Val Glu Lys 
    1130                 1135                 1140             


Tyr Asp  Gly Glu Ser Asp Lys  Glu Gln Phe Asp Asp  Asp Gln Lys 
    1145                 1150                 1155             


Val Cys  Cys Gly Phe Phe Phe  Lys Asp Asp Gln Lys  Ala Glu Asn 
    1160                 1165                 1170             


Asp Met  Ala Met Lys Arg Ala  Ala Leu Leu Glu Lys  Arg Leu Arg 
    1175                 1180                 1185             


Arg Glu  Lys Glu Thr Gln Leu  Arg Lys Gln Gln Leu  Glu Ala Glu 
    1190                 1195                 1200             


Met Glu  His Lys Lys Glu Glu  Thr Arg Arg Lys Thr  Glu Glu Glu 
    1205                 1210                 1215             


Arg Gln  Lys Lys Glu Asp Glu  Arg Ala Arg Arg Glu  Phe Ile Arg 
    1220                 1225                 1230             


Gln Glu  Tyr Met Arg Arg Lys  Gln Leu Lys Leu Met  Glu Asp Met 
    1235                 1240                 1245             


Asp Thr  Val Ile Lys Pro Arg  Pro Gln Val Val Lys  Gln Lys Lys 
    1250                 1255                 1260             


Gln Arg  Pro Lys Ser Ile His  Arg Asp His Ile Glu  Ser Pro Lys 
    1265                 1270                 1275             


Thr Pro  Ile Lys Gly Pro Pro  Val Ser Ser Leu Ser  Leu Ala Ser 
    1280                 1285                 1290             


Leu Asn  Thr Gly Asp Asn Glu  Ser Val His Ser Gly  Lys Arg Thr 
    1295                 1300                 1305             


Pro Arg  Ser Glu Ser Val Glu  Gly Phe Leu Ser Pro  Ser Arg Cys 
    1310                 1315                 1320             


Gly Ser  Arg Asn Gly Glu Lys  Asp Trp Glu Asn Ala  Ser Thr Thr 
    1325                 1330                 1335             


Ser Ser  Val Ala Ser Gly Thr  Glu Tyr Thr Gly Pro  Lys Leu Tyr 
    1340                 1345                 1350             


Lys Glu  Pro Ser Ala Lys Ser  Asn Lys His Ile Ile  Gln Asn Ala 
    1355                 1360                 1365             


Leu Ala  His Cys Cys Leu Ala  Gly Lys Val Asn Glu  Gly Gln Lys 
    1370                 1375                 1380             


Lys Lys  Ile Leu Glu Glu Met  Glu Lys Ser Asp Ala  Asn Asn Phe 
    1385                 1390                 1395             


Leu Ile  Leu Phe Arg Asp Ser  Gly Cys Gln Phe Arg  Ser Leu Tyr 
    1400                 1405                 1410             


Thr Tyr  Cys Pro Glu Thr Glu  Glu Ile Asn Lys Leu  Thr Gly Ile 
    1415                 1420                 1425             


Gly Pro  Lys Ser Ile Thr Lys  Lys Met Ile Glu Gly  Leu Tyr Lys 
    1430                 1435                 1440             


Tyr Asn  Ser Asp Arg Lys Gln  Phe Ser His Ile Pro  Ala Lys Thr 
    1445                 1450                 1455             


Leu Ser  Ala Ser Val Asp Ala  Ile Thr Ile His Ser  His Leu Trp 
    1460                 1465                 1470             


Gln Thr  Lys Arg Pro Val Thr  Pro Lys Lys Leu Leu  Pro Thr Lys 
    1475                 1480                 1485             


Ala 
    


<210>  146
<211>  506
<212>  PRT
<213>  Human papillomavirus type 23

<400>  146

Met Thr Leu Trp Leu Pro Ala Ser Gly Lys Ile Tyr Leu Pro Pro Thr 
1               5                   10                  15      


Pro Pro Val Ala Arg Val Gln Ser Thr Asp Glu Tyr Val Glu Arg Thr 
            20                  25                  30          


Asp Ile Tyr Tyr His Ala Thr Ser Asp Arg Leu Leu Thr Val Gly His 
        35                  40                  45              


Pro Tyr Phe Asp Val Arg Ser Pro Asp Gly Ser Lys Ile Asp Val Pro 
    50                  55                  60                  


Lys Val Ser Gly Asn Gln Phe Arg Ala Phe Arg Val Thr Phe Pro Asp 
65                  70                  75                  80  


Pro Asn Lys Phe Ala Leu Ala Asp Met Thr Ile Tyr Asp Pro Asp Lys 
                85                  90                  95      


Tyr Arg Leu Val Trp Ala Cys Ala Gly Leu Glu Ile Gly Arg Gly Gln 
            100                 105                 110         


Pro Leu Gly Val Gly Ser Thr Gly His Pro Leu Phe Asn Lys Leu Arg 
        115                 120                 125             


Asp Ala Glu Asn Ser Ser Glu Arg Gln Glu Gly Thr Val Asp Asp Arg 
    130                 135                 140                 


Arg Asn Ile Ser Phe Asp Pro Lys Gln Val Gln Met Phe Ile Ile Gly 
145                 150                 155                 160 


Cys Thr Pro Cys Leu Gly Glu Tyr Trp Asp Thr Ala Pro Val Cys Lys 
                165                 170                 175     


Asp Ala Gly Ser Gln Leu Gly Leu Cys Pro Pro Leu Glu Leu Lys Asn 
            180                 185                 190         


Ser Val Ile Glu Asp Gly Asp Met Phe Asp Ile Gly Phe Gly Asn Ile 
        195                 200                 205             


Asn Asn Lys Thr Leu Ser Phe Asn Arg Ser Asp Val Ser Leu Asp Leu 
    210                 215                 220                 


Val Asn Glu Val Cys Lys Tyr Pro Asp Phe Leu Thr Met Ser Asn Asp 
225                 230                 235                 240 


Val Tyr Gly Asp Ala Cys Phe Phe Cys Ala Arg Arg Glu Gln Cys Tyr 
                245                 250                 255     


Ala Arg His Tyr Phe Val Arg Gly Gly Val Val Gly Asp Ala Ile Pro 
            260                 265                 270         


Asp Gly Ala Val Gln Gln Asp His Lys Tyr Tyr Leu Pro Ala Asp Gln 
        275                 280                 285             


Gln Asn Thr Leu Glu Asn Ser Leu Tyr Phe Pro Thr Val Ser Gly Ser 
    290                 295                 300                 


Leu Val Thr Ser Asp Ser Gln Leu Phe Asn Arg Pro Phe Trp Leu Lys 
305                 310                 315                 320 


Arg Ala Gln Gly His Asn Asn Gly Ile Leu Trp Asn Asn Gln Met Phe 
                325                 330                 335     


Val Thr Val Ala Asp Asn Thr Arg Asn Thr Asn Phe Ser Ile Ser Val 
            340                 345                 350         


Thr Asn Asp Ser Ser Leu Glu Lys Tyr Asp Ala Thr Lys Ile Arg Glu 
        355                 360                 365             


Phe Thr Arg His Val Glu Glu Tyr Gln Leu Ser Phe Ile Leu Gln Leu 
    370                 375                 380                 


Cys Arg Ile Pro Leu Lys Ala Glu Val Leu Thr Gln Ile Asn Ala Met 
385                 390                 395                 400 


Asn Ser Asp Ile Leu Glu Asn Trp Gln Leu Gly Phe Val Pro Thr Pro 
                405                 410                 415     


Asp Asn Ala Val His Asp Thr Tyr Arg Tyr Leu Ala Ser Lys Ala Thr 
            420                 425                 430         


Lys Cys Pro Asp Ala Val Pro Asp Thr Gln Lys Glu Asp Pro Phe Gly 
        435                 440                 445             


Lys Tyr Ser Phe Trp Asn Val Asp Met Thr Glu Lys Leu Ser Leu Asp 
    450                 455                 460                 


Leu Asp Gln Tyr Pro Leu Gly Arg Lys Phe Leu Phe Gln Ile Gly Val 
465                 470                 475                 480 


Gln Arg Val Arg Ser Gly Thr Lys Arg Pro Ala Thr Arg Lys Val Thr 
                485                 490                 495     


Lys Thr Val Lys Arg Lys Lys Val Gln Leu 
            500                 505     


<210>  147
<211>  377
<212>  PRT
<213>  Homo sapiens

<400>  147

Met Ala Ser Ser Glu Gln Ala Glu Gln Pro Ser Gln Pro Ser Ser Thr 
1               5                   10                  15      


Pro Gly Ser Glu Asn Val Leu Pro Arg Glu Pro Leu Ile Ala Thr Ala 
            20                  25                  30          


Val Lys Phe Leu Gln Asn Ser Arg Val Arg Gln Ser Pro Leu Ala Thr 
        35                  40                  45              


Arg Arg Ala Phe Leu Lys Lys Lys Gly Leu Thr Asp Glu Glu Ile Asp 
    50                  55                  60                  


Met Ala Phe Gln Gln Ser Gly Thr Ala Ala Asp Glu Pro Ser Ser Leu 
65                  70                  75                  80  


Gly Pro Ala Thr Gln Val Val Pro Val Gln Pro Pro His Leu Ile Ser 
                85                  90                  95      


Gln Pro Tyr Ser Pro Ala Gly Ser Arg Trp Arg Asp Tyr Gly Ala Leu 
            100                 105                 110         


Ala Ile Ile Met Ala Gly Ile Ala Phe Gly Phe His Gln Leu Tyr Lys 
        115                 120                 125             


Lys Tyr Leu Leu Pro Leu Ile Leu Gly Gly Arg Glu Asp Arg Lys Gln 
    130                 135                 140                 


Leu Glu Arg Met Glu Ala Gly Leu Ser Glu Leu Ser Gly Ser Val Ala 
145                 150                 155                 160 


Gln Thr Val Thr Gln Leu Gln Thr Thr Leu Ala Ser Val Gln Glu Leu 
                165                 170                 175     


Leu Ile Gln Gln Gln Gln Lys Ile Gln Glu Leu Ala His Glu Leu Ala 
            180                 185                 190         


Ala Ala Lys Ala Thr Thr Ser Thr Asn Trp Ile Leu Glu Ser Gln Asn 
        195                 200                 205             


Ile Asn Glu Leu Lys Ser Glu Ile Asn Ser Leu Lys Gly Leu Leu Leu 
    210                 215                 220                 


Asn Arg Arg Gln Phe Pro Pro Ser Pro Ser Ala Pro Lys Ile Pro Ser 
225                 230                 235                 240 


Trp Gln Ile Pro Val Lys Ser Pro Ser Pro Ser Ser Pro Ala Ala Val 
                245                 250                 255     


Asn His His Ser Ser Ser Asp Ile Ser Pro Val Ser Asn Glu Ser Thr 
            260                 265                 270         


Ser Ser Ser Pro Gly Lys Glu Gly His Ser Pro Glu Gly Ser Thr Val 
        275                 280                 285             


Thr Tyr His Leu Leu Gly Pro Gln Glu Glu Gly Glu Gly Val Val Asp 
    290                 295                 300                 


Val Lys Gly Gln Val Arg Met Glu Val Gln Gly Glu Glu Glu Lys Arg 
305                 310                 315                 320 


Glu Asp Lys Glu Asp Glu Glu Asp Glu Glu Asp Asp Asp Val Ser His 
                325                 330                 335     


Val Asp Glu Glu Asp Cys Leu Gly Val Gln Arg Glu Asp Arg Arg Gly 
            340                 345                 350         


Gly Asp Gly Gln Ile Asn Glu Gln Val Glu Lys Leu Arg Arg Pro Glu 
        355                 360                 365             


Gly Ala Ser Asn Glu Ser Glu Arg Asp 
    370                 375         


<210>  148
<211>  4471
<212>  PRT
<213>  Homo sapiens

<400>  148

Met Val Pro Glu Glu Val Glu Val Glu Ile Asp Glu Ile Pro Val Leu 
1               5                   10                  15      


Ser Glu Glu Gly Glu Glu Glu Glu Glu Thr Tyr Ser Gln Lys Val Glu 
            20                  25                  30          


Ser Val Asp Lys Val Arg Ala Lys Arg Val Ser Leu Arg Thr Glu Ser 
        35                  40                  45              


Leu Gly Gln Pro Leu Asn Arg Glu Asp Glu Glu Met Asp Lys Glu Ile 
    50                  55                  60                  


Ser Glu Lys Leu Pro Ser Lys Arg Thr Ala Lys His Ile Met Glu Lys 
65                  70                  75                  80  


Met His Leu His Met Leu Cys Thr Pro Leu Pro Glu Glu Phe Leu Asp 
                85                  90                  95      


Gln Asn Val Val Phe Phe Leu Arg Asn Thr Lys Glu Ala Ile Ser Glu 
            100                 105                 110         


Ala Thr Asp Met Lys Glu Ala Met Glu Ile Met Pro Glu Thr Leu Glu 
        115                 120                 125             


Tyr Gly Ile Ile Asn Ala Asn Val Leu His Phe Leu Lys Asn Ile Ile 
    130                 135                 140                 


Cys Gln Val Phe Leu Pro Ala Leu Ser Phe Asn Gln His Arg Thr Ser 
145                 150                 155                 160 


Thr Thr Val Gly Val Thr Ser Gly Glu Val Ser Asn Ser Ser Glu His 
                165                 170                 175     


Glu Ser Asp Leu Pro Pro Met Pro Gly Glu Ala Val Glu Tyr His Ser 
            180                 185                 190         


Ile Gln Leu Ile Arg Asp Glu Phe Leu Met Asn Val Gln Lys Phe Ala 
        195                 200                 205             


Ser Asn Ile Gln Arg Thr Met Gln Gln Leu Glu Gly Glu Ile Lys Leu 
    210                 215                 220                 


Glu Met Pro Ile Ile Ser Val Glu Gly Glu Val Ser Asp Leu Ala Ala 
225                 230                 235                 240 


Asp Pro Glu Thr Val Asp Ile Leu Glu Gln Cys Val Ile Asn Trp Leu 
                245                 250                 255     


Asn Gln Ile Ser Thr Ala Val Glu Ala Gln Leu Lys Lys Thr Pro Gln 
            260                 265                 270         


Gly Lys Gly Pro Leu Ala Glu Ile Glu Phe Trp Arg Glu Arg Asn Ala 
        275                 280                 285             


Thr Leu Ser Ala Leu His Glu Gln Thr Lys Leu Pro Ile Val Arg Lys 
    290                 295                 300                 


Val Leu Asp Val Ile Lys Glu Ser Asp Ser Met Leu Val Ala Asn Leu 
305                 310                 315                 320 


Gln Pro Val Phe Thr Glu Leu Phe Lys Phe His Thr Glu Ala Ser Asp 
                325                 330                 335     


Asn Val Arg Phe Leu Ser Thr Val Glu Arg Tyr Phe Lys Asn Ile Thr 
            340                 345                 350         


His Gly Ser Gly Phe His Val Val Leu Asp Thr Ile Pro Ala Met Met 
        355                 360                 365             


Ser Ala Leu Arg Met Val Trp Ile Ile Ser Arg His Tyr Asn Lys Asp 
    370                 375                 380                 


Glu Arg Met Ile Pro Leu Met Glu Arg Ile Ala Trp Glu Ile Ala Glu 
385                 390                 395                 400 


Arg Val Cys Arg Val Val Asn Leu Arg Thr Leu Phe Lys Glu Asn Arg 
                405                 410                 415     


Ala Ser Ala Gln Ser Lys Thr Leu Glu Ala Arg Asn Thr Leu Arg Leu 
            420                 425                 430         


Trp Lys Lys Ala Tyr Phe Asp Thr Arg Ala Lys Ile Glu Ala Ser Gly 
        435                 440                 445             


Arg Glu Asp Arg Trp Glu Phe Asp Arg Lys Arg Leu Phe Glu Arg Thr 
    450                 455                 460                 


Asp Tyr Met Ala Thr Ile Cys Gln Asp Leu Ser Asp Val Leu Gln Val 
465                 470                 475                 480 


Leu Glu Glu Phe Tyr Asn Ile Phe Gly Pro Glu Leu Lys Ala Val Thr 
                485                 490                 495     


Gly Asp Pro Lys Arg Ile Asp Asp Val Leu Cys Arg Val Asp Gly Leu 
            500                 505                 510         


Val Thr Pro Met Glu Asn Leu Thr Phe Asp Pro Phe Ser Ile Lys Ser 
        515                 520                 525             


Ser Gln Phe Trp Lys Tyr Val Met Asp Glu Phe Lys Ile Glu Val Leu 
    530                 535                 540                 


Ile Asp Ile Ile Asn Lys Ile Phe Val Gln Asn Leu Glu Asn Pro Pro 
545                 550                 555                 560 


Leu Tyr Lys Asn His Pro Pro Val Ala Gly Ala Ile Tyr Trp Glu Arg 
                565                 570                 575     


Ser Leu Phe Phe Arg Ile Lys His Thr Ile Leu Arg Phe Gln Glu Val 
            580                 585                 590         


Gln Glu Ile Leu Asp Ser Asp Arg Gly Gln Glu Val Lys Gln Lys Tyr 
        595                 600                 605             


Leu Glu Val Gly Arg Thr Met Lys Glu Tyr Glu Asp Arg Lys Tyr Glu 
    610                 615                 620                 


Gln Trp Met Glu Val Thr Glu Gln Val Leu Pro Ala Leu Met Lys Lys 
625                 630                 635                 640 


Ser Leu Leu Thr Lys Ser Ser Ile Ala Thr Glu Glu Pro Ser Thr Leu 
                645                 650                 655     


Glu Arg Gly Ala Val Phe Ala Ile Asn Phe Ser Pro Ala Leu Arg Glu 
            660                 665                 670         


Ile Ile Asn Glu Thr Lys Tyr Leu Glu Gln Leu Gly Phe Thr Val Pro 
        675                 680                 685             


Glu Leu Ala Arg Asn Val Ala Leu Gln Glu Asp Lys Phe Leu Arg Tyr 
    690                 695                 700                 


Thr Ala Gly Ile Gln Arg Met Leu Asp His Tyr His Met Leu Ile Gly 
705                 710                 715                 720 


Thr Leu Asn Asp Ala Glu Ser Val Leu Leu Lys Asp His Ser Gln Glu 
                725                 730                 735     


Leu Leu Arg Val Phe Arg Ser Gly Tyr Lys Arg Leu Asn Trp Asn Ser 
            740                 745                 750         


Leu Gly Ile Gly Asp Tyr Ile Thr Gly Cys Lys Gln Ala Ile Gly Lys 
        755                 760                 765             


Phe Glu Ser Leu Val His Gln Ile His Lys Asn Ala Asp Asp Ile Ser 
    770                 775                 780                 


Ser Arg Leu Thr Leu Ile Glu Ala Ile Asn Leu Phe Lys Tyr Pro Ala 
785                 790                 795                 800 


Ala Lys Ser Glu Glu Glu Leu Pro Gly Val Lys Glu Phe Phe Glu His 
                805                 810                 815     


Ile Glu Arg Glu Arg Ala Ser Asp Val Asp His Met Val Arg Trp Tyr 
            820                 825                 830         


Leu Ala Ile Gly Pro Leu Leu Thr Lys Val Glu Gly Leu Val Val His 
        835                 840                 845             


Thr Asn Thr Gly Lys Ala Pro Lys Leu Ala Ser Tyr Tyr Lys Tyr Trp 
    850                 855                 860                 


Glu Lys Lys Ile Tyr Glu Val Leu Thr Lys Leu Ile Leu Lys Asn Leu 
865                 870                 875                 880 


Gln Ser Phe Asn Ser Leu Ile Leu Gly Asn Val Pro Leu Phe His Thr 
                885                 890                 895     


Glu Thr Ile Leu Thr Ala Pro Glu Ile Ile Leu His Pro Asn Thr Asn 
            900                 905                 910         


Glu Ile Asp Lys Met Cys Phe His Cys Val Arg Asn Cys Val Glu Ile 
        915                 920                 925             


Thr Lys His Phe Val Arg Trp Met Asn Gly Ser Cys Ile Glu Cys Pro 
    930                 935                 940                 


Pro Gln Lys Gly Glu Glu Glu Glu Val Val Ile Ile Asn Phe Tyr Asn 
945                 950                 955                 960 


Asp Ile Ser Leu Asn Pro Gln Ile Ile Glu Gln Ala Val Met Ile Pro 
                965                 970                 975     


Gln Asn Val His Arg Ile Leu Ile Asn Leu Met Lys Tyr Leu Gln Lys 
            980                 985                 990         


Trp Lys Arg Tyr Arg Pro Leu Trp  Lys Leu Asp Lys Ala  Ile Val Met 
        995                 1000                 1005             


Glu Lys  Phe Ala Ala Lys Lys  Pro Pro Cys Val Ala  Tyr Asp Glu 
    1010                 1015                 1020             


Lys Leu  Gln Phe Tyr Ser Lys  Ile Ala Tyr Glu Val  Met Arg His 
    1025                 1030                 1035             


Pro Leu  Ile Lys Asp Glu His  Cys Ile Arg Leu Gln  Leu Arg His 
    1040                 1045                 1050             


Leu Ala  Asn Thr Val Gln Glu  Asn Ala Lys Ser Trp  Val Ile Ser 
    1055                 1060                 1065             


Leu Gly  Lys Leu Leu Asn Glu  Ser Ala Lys Glu Glu  Leu Tyr Asn 
    1070                 1075                 1080             


Leu His  Glu Glu Met Glu His  Leu Ala Lys Asn Leu  Arg Lys Ile 
    1085                 1090                 1095             


Pro Asn  Thr Leu Glu Asp Leu  Lys Phe Val Leu Ala  Thr Ile Ala 
    1100                 1105                 1110             


Glu Ile  Arg Ser Lys Ser Leu  Val Met Glu Leu Arg  Tyr Arg Asp 
    1115                 1120                 1125             


Val Gln  Glu Arg Tyr Arg Thr  Met Ala Met Tyr Asn  Leu Phe Pro 
    1130                 1135                 1140             


Pro Asp  Ala Glu Lys Glu Leu  Val Asp Lys Ile Glu  Ser Ile Trp 
    1145                 1150                 1155             


Ser Asn  Leu Phe Asn Asp Ser  Val Asn Val Glu His  Ala Leu Gly 
    1160                 1165                 1170             


Asp Ile  Lys Arg Thr Phe Thr  Glu Leu Thr Arg Gly  Glu Ile Met 
    1175                 1180                 1185             


Asn Tyr  Arg Val Gln Ile Glu  Glu Phe Ala Lys Arg  Phe Tyr Ser 
    1190                 1195                 1200             


Glu Gly  Pro Gly Ser Val Gly  Asp Asp Leu Asp Lys  Gly Val Glu 
    1205                 1210                 1215             


Leu Leu  Gly Val Tyr Glu Arg  Glu Leu Ala Arg His  Glu Lys Ser 
    1220                 1225                 1230             


Arg Gln  Glu Leu Ala Asn Ala  Glu Lys Leu Phe Asp  Leu Pro Ile 
    1235                 1240                 1245             


Thr Met  Tyr Pro Glu Leu Leu  Lys Val Gln Lys Glu  Met Ser Gly 
    1250                 1255                 1260             


Leu Arg  Met Ile Tyr Glu Leu  Tyr Glu Gly Leu Lys  Val Ala Lys 
    1265                 1270                 1275             


Glu Glu  Trp Ser Gln Thr Leu  Trp Ile Asn Leu Asn  Val Gln Ile 
    1280                 1285                 1290             


Leu Gln  Glu Gly Ile Glu Gly  Phe Leu Arg Ala Leu  Arg Lys Leu 
    1295                 1300                 1305             


Pro Arg  Pro Val Arg Gly Leu  Ser Val Thr Tyr Tyr  Leu Glu Ala 
    1310                 1315                 1320             


Lys Met  Lys Ala Phe Lys Asp  Ser Ile Pro Leu Leu  Leu Asp Leu 
    1325                 1330                 1335             


Lys Asn  Glu Ala Leu Arg Asp  Arg His Trp Lys Glu  Leu Met Glu 
    1340                 1345                 1350             


Lys Thr  Ser Val Phe Phe Glu  Met Thr Glu Thr Phe  Thr Leu Glu 
    1355                 1360                 1365             


Asn Met  Phe Ala Met Glu Leu  His Lys His Thr Asp  Val Leu Asn 
    1370                 1375                 1380             


Glu Ile  Val Thr Ala Ala Ile  Lys Glu Val Ala Ile  Glu Lys Ala 
    1385                 1390                 1395             


Val Lys  Glu Ile Leu Asp Thr  Trp Glu Asn Met Lys  Phe Thr Val 
    1400                 1405                 1410             


Val Lys  Tyr Cys Lys Gly Thr  Gln Glu Arg Gly Tyr  Ile Leu Gly 
    1415                 1420                 1425             


Ser Val  Asp Glu Ile Ile Gln  Ser Leu Asp Asp Asn  Thr Phe Asn 
    1430                 1435                 1440             


Leu Gln  Ser Ile Ser Gly Ser  Arg Phe Val Gly Pro  Phe Leu Gln 
    1445                 1450                 1455             


Thr Val  His Lys Trp Glu Lys  Thr Leu Ser Leu Ile  Gly Glu Val 
    1460                 1465                 1470             


Ile Glu  Ile Trp Met Leu Val  Gln Arg Lys Trp Met  Tyr Leu Glu 
    1475                 1480                 1485             


Ser Ile  Phe Ile Gly Gly Asp  Ile Arg Ser Gln Leu  Pro Glu Glu 
    1490                 1495                 1500             


Ala Lys  Lys Phe Asp Asn Ile  Asp Lys Val Phe Lys  Arg Ile Met 
    1505                 1510                 1515             


Gly Glu  Thr Leu Lys Asp Pro  Val Ile Lys Arg Cys  Cys Glu Ala 
    1520                 1525                 1530             


Pro Asn  Arg Leu Ser Asp Leu  Gln Asn Val Ser Glu  Gly Leu Glu 
    1535                 1540                 1545             


Lys Cys  Gln Lys Ser Leu Asn  Asp Tyr Leu Asp Ser  Lys Arg Asn 
    1550                 1555                 1560             


Ala Phe  Pro Arg Phe Phe Phe  Ile Ser Asp Asp Glu  Leu Leu Ser 
    1565                 1570                 1575             


Ile Leu  Gly Ser Ser Asp Pro  Leu Cys Val Gln Glu  His Met Ile 
    1580                 1585                 1590             


Lys Met  Tyr Asp Asn Ile Ala  Ser Leu Arg Phe Asn  Asp Gly Asp 
    1595                 1600                 1605             


Ser Gly  Glu Lys Leu Val Ser  Ala Met Ile Ser Ala  Glu Gly Glu 
    1610                 1615                 1620             


Val Met  Glu Phe Arg Lys Ile  Val Arg Ala Glu Gly  Arg Val Glu 
    1625                 1630                 1635             


Asp Trp  Met Thr Ala Val Leu  Asn Glu Met Arg Arg  Thr Asn Arg 
    1640                 1645                 1650             


Leu Ile  Thr Lys Glu Ala Ile  Phe Arg Tyr Cys Glu  Asp Arg Ser 
    1655                 1660                 1665             


Arg Val  Asp Trp Met Leu Leu  Tyr Gln Gly Met Val  Val Leu Ala 
    1670                 1675                 1680             


Ala Ser  Gln Val Trp Trp Thr  Trp Glu Val Glu Asp  Val Phe His 
    1685                 1690                 1695             


Lys Ala  Gln Lys Gly Glu Lys  Gln Ala Met Lys Asn  Tyr Gly Arg 
    1700                 1705                 1710             


Lys Met  His Arg Gln Ile Asp  Glu Leu Val Thr Arg  Ile Thr Met 
    1715                 1720                 1725             


Pro Leu  Ser Lys Asn Asp Arg  Lys Lys Tyr Asn Thr  Val Leu Ile 
    1730                 1735                 1740             


Ile Asp  Val His Ala Arg Asp  Ile Val Asp Ser Phe  Ile Arg Gly 
    1745                 1750                 1755             


Ser Ile  Leu Glu Ala Arg Glu  Phe Asp Trp Glu Ser  Gln Leu Arg 
    1760                 1765                 1770             


Phe Tyr  Trp Asp Arg Glu Pro  Asp Glu Leu Asn Ile  Arg Gln Cys 
    1775                 1780                 1785             


Thr Gly  Thr Phe Gly Tyr Gly  Tyr Glu Tyr Met Gly  Leu Asn Gly 
    1790                 1795                 1800             


Arg Leu  Val Ile Thr Pro Leu  Thr Asp Arg Ile Tyr  Leu Thr Leu 
    1805                 1810                 1815             


Thr Gln  Ala Leu Ser Met Tyr  Leu Gly Gly Ala Pro  Ala Gly Pro 
    1820                 1825                 1830             


Ala Gly  Thr Gly Lys Thr Glu  Thr Thr Lys Asp Leu  Ala Lys Ala 
    1835                 1840                 1845             


Leu Gly  Leu Leu Cys Val Val  Thr Asn Cys Gly Glu  Gly Met Asp 
    1850                 1855                 1860             


Tyr Arg  Ala Val Gly Lys Ile  Phe Ser Gly Leu Ala  Gln Cys Gly 
    1865                 1870                 1875             


Ala Trp  Gly Cys Phe Asp Glu  Phe Asn Arg Ile Asp  Ala Ser Val 
    1880                 1885                 1890             


Leu Ser  Val Ile Ser Ser Gln  Ile Gln Thr Ile Arg  Asn Ala Leu 
    1895                 1900                 1905             


Ile His  Gln Leu Thr Thr Phe  Gln Phe Glu Gly Gln  Glu Ile Ser 
    1910                 1915                 1920             


Leu Asp  Ser Arg Met Gly Ile  Phe Ile Thr Met Asn  Pro Gly Tyr 
    1925                 1930                 1935             


Ala Gly  Arg Thr Glu Leu Pro  Glu Ser Val Lys Ala  Leu Phe Arg 
    1940                 1945                 1950             


Pro Val  Val Val Ile Val Pro  Asp Leu Gln Gln Ile  Cys Glu Ile 
    1955                 1960                 1965             


Met Leu  Phe Ser Glu Gly Phe  Leu Glu Ala Lys Thr  Leu Ala Lys 
    1970                 1975                 1980             


Lys Met  Thr Val Leu Tyr Lys  Leu Ala Arg Glu Gln  Leu Ser Lys 
    1985                 1990                 1995             


Gln Tyr  His Tyr Asp Phe Gly  Leu Arg Ala Leu Lys  Ser Val Leu 
    2000                 2005                 2010             


Val Met  Ala Gly Glu Leu Lys  Arg Gly Ser Ser Asp  Leu Arg Glu 
    2015                 2020                 2025             


Asp Val  Val Leu Met Arg Ala  Leu Arg Asp Met Asn  Leu Pro Lys 
    2030                 2035                 2040             


Phe Val  Phe Glu Asp Val Pro  Leu Phe Leu Gly Leu  Ile Ser Asp 
    2045                 2050                 2055             


Leu Phe  Pro Gly Leu Asp Cys  Pro Arg Val Arg Tyr  Pro Asp Phe 
    2060                 2065                 2070             


Asn Asp  Ala Val Glu Gln Val  Leu Glu Glu Asn Gly  Tyr Ala Val 
    2075                 2080                 2085             


Leu Pro  Ile Gln Val Asp Lys  Val Val Gln Met Phe  Glu Thr Met 
    2090                 2095                 2100             


Leu Thr  Arg His Thr Thr Met  Val Val Gly Pro Thr  Arg Gly Gly 
    2105                 2110                 2115             


Lys Ser  Val Val Ile Asn Thr  Leu Cys Gln Ala Gln  Thr Lys Leu 
    2120                 2125                 2130             


Gly Leu  Thr Thr Lys Leu Tyr  Ile Leu Asn Pro Lys  Ala Val Ser 
    2135                 2140                 2145             


Val Ile  Glu Leu Tyr Gly Ile  Leu Asp Pro Thr Thr  Arg Asp Trp 
    2150                 2155                 2160             


Thr Asp  Gly Val Leu Ser Asn  Ile Phe Arg Glu Ile  Asn Lys Pro 
    2165                 2170                 2175             


Thr Asp  Lys Lys Glu Arg Lys  Tyr Ile Leu Phe Asp  Gly Asp Val 
    2180                 2185                 2190             


Asp Ala  Leu Trp Val Glu Asn  Met Asn Ser Val Met  Asp Asp Asn 
    2195                 2200                 2205             


Arg Leu  Leu Thr Leu Ala Asn  Gly Glu Arg Ile Arg  Leu Gln Ala 
    2210                 2215                 2220             


His Cys  Ala Leu Leu Phe Glu  Val Gly Asp Leu Gln  Tyr Ala Ser 
    2225                 2230                 2235             


Pro Ala  Thr Val Ser Arg Cys  Gly Met Val Tyr Val  Asp Pro Lys 
    2240                 2245                 2250             


Asn Leu  Lys Tyr Arg Pro Tyr  Trp Lys Lys Trp Val  Asn Gln Ile 
    2255                 2260                 2265             


Pro Asn  Lys Val Glu Gln Tyr  Asn Leu Asn Ser Leu  Phe Glu Lys 
    2270                 2275                 2280             


Tyr Val  Pro Tyr Leu Met Asp  Val Ile Val Glu Gly  Ile Val Asp 
    2285                 2290                 2295             


Gly Arg  Gln Ala Glu Lys Leu  Lys Thr Ile Val Pro  Gln Thr Asp 
    2300                 2305                 2310             


Leu Asn  Met Val Thr Gln Leu  Ala Lys Met Leu Asp  Ala Leu Leu 
    2315                 2320                 2325             


Glu Gly  Glu Ile Glu Asp Leu  Asp Leu Leu Glu Cys  Tyr Phe Leu 
    2330                 2335                 2340             


Glu Ala  Leu Tyr Cys Ser Leu  Gly Ala Ser Leu Leu  Glu Asp Gly 
    2345                 2350                 2355             


Arg Met  Lys Phe Asp Glu Tyr  Ile Lys Arg Leu Ala  Ser Leu Ser 
    2360                 2365                 2370             


Thr Val  Asp Thr Glu Gly Val  Trp Ala Asn Pro Gly  Glu Leu Pro 
    2375                 2380                 2385             


Gly Gln  Leu Pro Thr Leu Tyr  Asp Phe His Phe Asp  Asn Lys Arg 
    2390                 2395                 2400             


Asn Gln  Trp Val Pro Trp Ser  Lys Leu Val Pro Glu  Tyr Ile His 
    2405                 2410                 2415             


Ala Pro  Glu Arg Lys Phe Ile  Asn Ile Leu Val His  Thr Val Asp 
    2420                 2425                 2430             


Thr Thr  Arg Thr Thr Trp Ile  Leu Glu Gln Met Val  Lys Ile Lys 
    2435                 2440                 2445             


Gln Pro  Val Ile Phe Val Gly  Glu Ser Gly Thr Ser  Lys Thr Ala 
    2450                 2455                 2460             


Thr Thr  Gln Asn Phe Leu Lys  Asn Leu Ser Glu Glu  Thr Asn Ile 
    2465                 2470                 2475             


Val Leu  Met Val Asn Phe Ser  Ser Arg Thr Thr Ser  Met Asp Ile 
    2480                 2485                 2490             


Gln Arg  Asn Leu Glu Ala Asn  Val Glu Lys Arg Thr  Lys Asp Thr 
    2495                 2500                 2505             


Tyr Gly  Pro Pro Met Gly Lys  Arg Leu Leu Val Phe  Met Asp Asp 
    2510                 2515                 2520             


Met Asn  Met Pro Arg Val Asp  Glu Tyr Gly Thr Gln  Gln Pro Ile 
    2525                 2530                 2535             


Ala Leu  Leu Lys Leu Leu Leu  Glu Lys Gly Tyr Leu  Tyr Asp Arg 
    2540                 2545                 2550             


Gly Lys  Glu Leu Asn Cys Lys  Ser Ile Arg Asp Leu  Gly Phe Ile 
    2555                 2560                 2565             


Ala Ala  Met Gly Lys Ala Gly  Gly Gly Arg Asn Glu  Val Asp Pro 
    2570                 2575                 2580             


Arg Phe  Ile Ser Leu Phe Ser  Val Phe Asn Val Pro  Phe Pro Ser 
    2585                 2590                 2595             


Glu Glu  Ser Leu His Leu Ile  Tyr Ser Ser Ile Leu  Lys Gly His 
    2600                 2605                 2610             


Thr Ser  Thr Phe His Glu Ser  Ile Val Ala Val Ser  Gly Lys Leu 
    2615                 2620                 2625             


Thr Phe  Cys Thr Leu Ala Leu  Tyr Lys Asn Ile Val  Gln Asp Leu 
    2630                 2635                 2640             


Pro Pro  Thr Pro Ser Lys Phe  His Tyr Ile Phe Asn  Leu Arg Asp 
    2645                 2650                 2655             


Leu Ser  Arg Val Phe Asn Gly  Leu Val Leu Thr Asn  Pro Glu Arg 
    2660                 2665                 2670             


Phe Gln  Thr Val Ala Gln Met  Val Arg Val Trp Arg  Asn Glu Cys 
    2675                 2680                 2685             


Leu Arg  Val Phe His Asp Arg  Leu Ile Ser Glu Thr  Asp Lys Gln 
    2690                 2695                 2700             


Leu Val  Gln Gln His Ile Gly  Ser Leu Val Val Glu  His Phe Lys 
    2705                 2710                 2715             


Asp Asp  Val Glu Val Val Met  Arg Asp Pro Ile Leu  Phe Gly Asp 
    2720                 2725                 2730             


Phe Gln  Met Ala Leu His Glu  Gly Glu Pro Arg Ile  Tyr Glu Asp 
    2735                 2740                 2745             


Ile Gln  Asp Tyr Glu Ala Ala  Lys Ala Leu Phe Gln  Glu Ile Leu 
    2750                 2755                 2760             


Glu Glu  Tyr Asn Glu Ser Asn  Thr Lys Met Asn Leu  Val Leu Phe 
    2765                 2770                 2775             


Asp Asp  Ala Leu Glu His Leu  Thr Arg Val His Arg  Ile Ile Arg 
    2780                 2785                 2790             


Met Asp  Arg Gly His Ala Leu  Leu Val Gly Val Gly  Gly Ser Gly 
    2795                 2800                 2805             


Lys Gln  Ser Leu Ser Arg Leu  Ala Ala Phe Thr Ala  Ser Cys Glu 
    2810                 2815                 2820             


Val Phe  Glu Ile Leu Leu Ser  Arg Gly Tyr Ser Glu  Asn Ser Phe 
    2825                 2830                 2835             


Arg Glu  Asp Leu Lys Ser Leu  Tyr Leu Lys Leu Gly  Ile Glu Asn 
    2840                 2845                 2850             


Lys Ala  Met Ile Phe Leu Phe  Thr Asp Ala His Val  Ala Glu Glu 
    2855                 2860                 2865             


Gly Phe  Leu Glu Leu Ile Asn  Asn Met Leu Thr Ser  Gly Ile Val 
    2870                 2875                 2880             


Pro Ala  Leu Phe Ser Glu Glu  Glu Lys Glu Ser Ile  Leu Ser Gln 
    2885                 2890                 2895             


Ile Gly  Gln Glu Ala Leu Lys  Gln Gly Met Gly Pro  Ala Lys Glu 
    2900                 2905                 2910             


Ser Val  Trp Gln Tyr Phe Val  Asn Lys Ser Ala Asn  Asn Leu His 
    2915                 2920                 2925             


Ile Val  Leu Gly Met Ser Pro  Val Gly Asp Thr Leu  Arg Thr Trp 
    2930                 2935                 2940             


Cys Arg  Asn Phe Pro Gly Met  Val Asn Asn Thr Gly  Ile Asp Trp 
    2945                 2950                 2955             


Phe Met  Pro Trp Pro Pro Gln  Ala Leu His Ala Val  Ala Lys Ser 
    2960                 2965                 2970             


Phe Leu  Gly Tyr Asn Pro Met  Ile Pro Ala Glu Asn  Ile Glu Asn 
    2975                 2980                 2985             


Val Val  Lys His Val Val Leu  Val His Gln Ser Val  Asp His Tyr 
    2990                 2995                 3000             


Ser Gln  Gln Phe Leu Gln Lys  Leu Arg Arg Ser Asn  Tyr Val Thr 
    3005                 3010                 3015             


Pro Lys  Asn Tyr Leu Asp Phe  Ile Asn Thr Tyr Ser  Lys Leu Leu 
    3020                 3025                 3030             


Asp Glu  Lys Thr Gln Cys Asn  Ile Ala Gln Cys Lys  Arg Leu Asp 
    3035                 3040                 3045             


Gly Gly  Leu Asp Lys Leu Lys  Glu Ala Thr Ile Gln  Leu Asp Glu 
    3050                 3055                 3060             


Leu Asn  Gln Lys Leu Ala Glu  Gln Lys Ile Val Leu  Ala Glu Lys 
    3065                 3070                 3075             


Ser Ala  Ala Cys Glu Ala Leu  Leu Glu Glu Ile Ala  Val Asn Thr 
    3080                 3085                 3090             


Ala Val  Ala Glu Glu Lys Lys  Lys Leu Ala Glu Glu  Lys Ala Met 
    3095                 3100                 3105             


Glu Ile  Glu Glu Gln Asn Lys  Val Ile Ala Met Glu  Lys Ala Glu 
    3110                 3115                 3120             


Ala Glu  Thr Thr Leu Ala Glu  Val Met Pro Ile Leu  Glu Ala Ala 
    3125                 3130                 3135             


Lys Leu  Glu Leu Gln Lys Leu  Asp Lys Ser Asp Val  Thr Glu Ile 
    3140                 3145                 3150             


Arg Ser  Phe Ala Lys Pro Pro  Lys Gln Val Gln Thr  Val Cys Glu 
    3155                 3160                 3165             


Cys Ile  Leu Ile Met Lys Gly  Tyr Lys Glu Leu Asn  Trp Lys Thr 
    3170                 3175                 3180             


Ala Lys  Gly Val Met Ser Asp  Pro Asn Phe Leu Arg  Ser Leu Met 
    3185                 3190                 3195             


Glu Ile  Asp Phe Asp Ser Ile  Thr Gln Ser Gln Val  Lys Asn Ile 
    3200                 3205                 3210             


Lys Gly  Leu Leu Lys Thr Leu  Asn Thr Thr Thr Glu  Glu Met Glu 
    3215                 3220                 3225             


Ala Val  Ser Lys Ala Gly Leu  Gly Met Leu Lys Phe  Val Glu Ala 
    3230                 3235                 3240             


Val Met  Gly Tyr Cys Asp Val  Phe Arg Glu Ile Lys  Pro Lys Arg 
    3245                 3250                 3255             


Glu Lys  Val Ala Arg Leu Glu  Arg Asn Phe Tyr Leu  Thr Lys Arg 
    3260                 3265                 3270             


Glu Leu  Glu Arg Ile Gln Asn  Glu Leu Ala Ala Ile  Gln Lys Glu 
    3275                 3280                 3285             


Leu Glu  Thr Leu Gly Ala Lys  Tyr Glu Ala Ala Ile  Leu Glu Lys 
    3290                 3295                 3300             


Gln Lys  Leu Gln Glu Glu Ala  Glu Ile Met Glu Arg  Arg Leu Ile 
    3305                 3310                 3315             


Ala Ala  Asp Lys Leu Ile Ser  Gly Leu Gly Ser Glu  Asn Ile Arg 
    3320                 3325                 3330             


Trp Leu  Asn Asp Leu Asp Glu  Leu Met His Arg Arg  Val Lys Leu 
    3335                 3340                 3345             


Leu Gly  Asp Cys Leu Leu Cys  Ala Ala Phe Leu Ser  Tyr Glu Gly 
    3350                 3355                 3360             


Ala Phe  Thr Trp Glu Phe Arg  Asp Glu Met Val Asn  Arg Ile Trp 
    3365                 3370                 3375             


Gln Asn  Asp Ile Leu Glu Arg  Glu Ile Pro Leu Ser  Gln Pro Phe 
    3380                 3385                 3390             


Arg Leu  Glu Ser Leu Leu Thr  Asp Asp Val Glu Ile  Ser Arg Trp 
    3395                 3400                 3405             


Gly Ser  Gln Gly Leu Pro Pro  Asp Glu Leu Ser Val  Gln Asn Gly 
    3410                 3415                 3420             


Ile Leu  Thr Thr Arg Ala Ser  Arg Phe Pro Leu Cys  Ile Asp Pro 
    3425                 3430                 3435             


Gln Gln  Gln Ala Leu Asn Trp  Ile Lys Arg Lys Glu  Glu Lys Asn 
    3440                 3445                 3450             


Asn Leu  Arg Val Ala Ser Phe  Asn Asp Pro Asp Phe  Leu Lys Gln 
    3455                 3460                 3465             


Leu Glu  Met Ser Ile Lys Tyr  Gly Thr Pro Phe Leu  Phe Arg Asp 
    3470                 3475                 3480             


Val Asp  Glu Tyr Ile Asp Pro  Val Ile Asp Asn Val  Leu Glu Lys 
    3485                 3490                 3495             


Asn Ile  Lys Val Ser Gln Gly  Arg Gln Phe Ile Ile  Leu Gly Asp 
    3500                 3505                 3510             


Lys Glu  Val Asp Tyr Asp Ser  Asn Phe Arg Leu Tyr  Leu Asn Thr 
    3515                 3520                 3525             


Lys Leu  Ala Asn Pro Arg Tyr  Ser Pro Ser Val Phe  Gly Lys Ala 
    3530                 3535                 3540             


Met Val  Ile Asn Tyr Thr Val  Thr Leu Lys Gly Leu  Glu Asp Gln 
    3545                 3550                 3555             


Leu Leu  Ser Val Leu Val Ala  Tyr Glu Arg Arg Glu  Leu Glu Glu 
    3560                 3565                 3570             


Gln Arg  Glu His Leu Ile Gln  Glu Thr Ser Glu Asn  Lys Asn Leu 
    3575                 3580                 3585             


Leu Lys  Asp Leu Glu Asp Ser  Leu Leu Arg Glu Leu  Ala Thr Ser 
    3590                 3595                 3600             


Thr Gly  Asn Met Leu Asp Asn  Val Asp Leu Val His  Thr Leu Glu 
    3605                 3610                 3615             


Glu Thr  Lys Ser Lys Ala Thr  Glu Val Ser Glu Lys  Leu Lys Leu 
    3620                 3625                 3630             


Ala Glu  Lys Thr Ala Leu Asp  Ile Asp Arg Leu Arg  Asp Gly Tyr 
    3635                 3640                 3645             


Arg Pro  Ala Ala Arg Arg Gly  Ala Ile Leu Phe Phe  Val Leu Ser 
    3650                 3655                 3660             


Glu Met  Ala Leu Val Asn Ser  Met Tyr Gln Tyr Ser  Leu Ile Ala 
    3665                 3670                 3675             


Phe Leu  Glu Val Phe Arg Leu  Ser Leu Lys Lys Ser  Leu Pro Asp 
    3680                 3685                 3690             


Ser Ile  Leu Met Lys Arg Leu  Arg Asn Ile Met Asp  Thr Leu Thr 
    3695                 3700                 3705             


Phe Ser  Ile Tyr Asn His Gly  Cys Thr Gly Leu Phe  Glu Arg His 
    3710                 3715                 3720             


Lys Leu  Leu Phe Ser Phe Asn  Met Thr Ile Lys Ile  Glu Gln Ala 
    3725                 3730                 3735             


Glu Gly  Arg Val Pro Gln Glu  Glu Leu Asp Phe Phe  Leu Lys Gly 
    3740                 3745                 3750             


Asn Ile  Ser Leu Glu Lys Ser  Lys Arg Lys Lys Pro  Cys Ala Trp 
    3755                 3760                 3765             


Leu Ser  Asp Gln Gly Trp Glu  Asp Ile Ile Leu Leu  Ser Glu Met 
    3770                 3775                 3780             


Phe Ser  Asp Asn Phe Gly Gln  Leu Pro Asp Asp Val  Glu Asn Asn 
    3785                 3790                 3795             


Gln Thr  Val Trp Gln Glu Trp  Tyr Asp Leu Asp Ser  Leu Glu Gln 
    3800                 3805                 3810             


Phe Pro  Val Pro Leu Gly Tyr  Asp Asn Asn Ile Thr  Pro Phe Gln 
    3815                 3820                 3825             


Lys Leu  Leu Ile Leu Arg Cys  Phe Arg Val Asp Arg  Val Tyr Arg 
    3830                 3835                 3840             


Ala Val  Thr Asp Tyr Val Thr  Val Thr Met Gly Glu  Lys Tyr Val 
    3845                 3850                 3855             


Gln Pro  Pro Met Ile Ser Phe  Glu Ala Ile Phe Glu  Gln Ser Thr 
    3860                 3865                 3870             


Pro His  Ser Pro Ile Val Phe  Ile Leu Ser Pro Gly  Ser Asp Pro 
    3875                 3880                 3885             


Ala Thr  Asp Leu Met Lys Leu  Ala Glu Arg Ser Gly  Phe Gly Gly 
    3890                 3895                 3900             


Asn Arg  Leu Lys Phe Leu Ala  Met Gly Gln Gly Gln  Glu Lys Val 
    3905                 3910                 3915             


Ala Leu  Gln Leu Leu Glu Thr  Ala Val Ala Arg Gly  Gln Trp Leu 
    3920                 3925                 3930             


Met Leu  Gln Asn Cys His Leu  Leu Val Lys Trp Leu  Lys Asp Leu 
    3935                 3940                 3945             


Glu Lys  Ser Leu Glu Arg Ile  Thr Lys Pro His Pro  Asp Phe Arg 
    3950                 3955                 3960             


Leu Trp  Leu Thr Thr Asp Pro  Thr Lys Gly Phe Pro  Ile Gly Ile 
    3965                 3970                 3975             


Leu Gln  Lys Ser Leu Lys Val  Val Thr Glu Pro Pro  Asn Gly Leu 
    3980                 3985                 3990             


Lys Leu  Asn Met Arg Ala Thr  Tyr Phe Lys Ile Ser  His Glu Met 
    3995                 4000                 4005             


Leu Asp  Gln Cys Pro His Pro  Ala Phe Lys Pro Leu  Val Tyr Val 
    4010                 4015                 4020             


Leu Ala  Phe Phe His Ala Val  Val Gln Glu Arg Arg  Lys Phe Gly 
    4025                 4030                 4035             


Lys Ile  Gly Trp Asn Val Tyr  Tyr Asp Phe Asn Glu  Ser Asp Phe 
    4040                 4045                 4050             


Gln Val  Cys Met Glu Ile Leu  Asn Thr Tyr Leu Thr  Lys Ala Phe 
    4055                 4060                 4065             


Gln Gln  Arg Asp Pro Arg Ile  Pro Trp Gly Ser Leu  Lys Tyr Leu 
    4070                 4075                 4080             


Ile Gly  Glu Val Met Tyr Gly  Gly Arg Ala Ile Asp  Ser Phe Asp 
    4085                 4090                 4095             


Arg Arg  Ile Leu Thr Ile Tyr  Met Asp Glu Tyr Leu  Gly Asp Phe 
    4100                 4105                 4110             


Ile Phe  Asp Thr Phe Gln Pro  Phe His Phe Phe Arg  Asn Lys Glu 
    4115                 4120                 4125             


Val Asp  Tyr Lys Ile Pro Val  Gly Asp Glu Lys Glu  Lys Phe Val 
    4130                 4135                 4140             


Glu Ala  Ile Glu Ala Leu Pro  Leu Ala Asn Thr Pro  Glu Val Phe 
    4145                 4150                 4155             


Gly Leu  His Pro Asn Ala Glu  Ile Gly Tyr Tyr Thr  Gln Ala Ala 
    4160                 4165                 4170             


Arg Asp  Met Trp Ala His Leu  Leu Glu Leu Gln Pro  Gln Thr Gly 
    4175                 4180                 4185             


Glu Ser  Ser Ser Gly Ile Ser  Arg Asp Asp Tyr Ile  Gly Gln Val 
    4190                 4195                 4200             


Ala Lys  Glu Ile Glu Asn Lys  Met Pro Lys Val Phe  Asp Leu Asp 
    4205                 4210                 4215             


Gln Val  Arg Lys Arg Leu Gly  Thr Gly Leu Ser Pro  Thr Ser Val 
    4220                 4225                 4230             


Val Leu  Leu Gln Glu Leu Glu  Arg Phe Asn Lys Leu  Val Val Arg 
    4235                 4240                 4245             


Met Thr  Lys Ser Leu Ala Glu  Leu Gln Arg Ala Leu  Ala Gly Glu 
    4250                 4255                 4260             


Val Gly  Met Ser Asn Glu Leu  Asp Asp Val Ala Arg  Ser Leu Phe 
    4265                 4270                 4275             


Ile Gly  His Ile Pro Asn Ile  Trp Arg Arg Leu Ala  Pro Asp Thr 
    4280                 4285                 4290             


Leu Lys  Ser Leu Gly Asn Trp  Met Val Tyr Phe Leu  Arg Arg Phe 
    4295                 4300                 4305             


Ser Gln  Tyr Met Leu Trp Val  Thr Glu Ser Glu Pro  Ser Val Met 
    4310                 4315                 4320             


Trp Leu  Ser Gly Leu His Ile  Pro Glu Ser Tyr Leu  Thr Ala Leu 
    4325                 4330                 4335             


Val Gln  Ala Thr Cys Arg Lys  Asn Gly Trp Pro Leu  Asp Arg Ser 
    4340                 4345                 4350             


Thr Leu  Phe Thr Gln Val Thr  Lys Phe Gln Asp Ala  Asp Glu Val 
    4355                 4360                 4365             


Asn Glu  Arg Ala Gly Gln Gly  Cys Phe Val Ser Gly  Leu Tyr Leu 
    4370                 4375                 4380             


Glu Gly  Ala Asp Trp Asp Ile  Glu Lys Gly Cys Leu  Ile Lys Ser 
    4385                 4390                 4395             


Lys Pro  Lys Val Leu Val Val  Asp Leu Pro Ile Leu  Lys Ile Ile 
    4400                 4405                 4410             


Pro Ile  Glu Ala His Arg Leu  Lys Leu Gln Asn Thr  Phe Arg Thr 
    4415                 4420                 4425             


Pro Val  Tyr Thr Thr Ser Met  Arg Arg Asn Ala Met  Gly Val Gly 
    4430                 4435                 4440             


Leu Val  Phe Glu Ala Asp Leu  Phe Thr Thr Arg His  Ile Ser His 
    4445                 4450                 4455             


Trp Val  Leu Gln Gly Val Cys  Leu Thr Leu Asn Ser  Asp 
    4460                 4465                 4470     


<210>  149
<211>  534
<212>  PRT
<213>  Homo sapiens

<400>  149

Met Thr Gln Ala Glu Ile Lys Leu Cys Ser Leu Leu Leu Gln Glu His 
1               5                   10                  15      


Phe Gly Glu Ile Val Glu Lys Ile Gly Val His Leu Ile Arg Thr Gly 
            20                  25                  30          


Ser Gln Pro Leu Arg Val Ile Ala His Asp Thr Gly Thr Ser Leu Asp 
        35                  40                  45              


Gln Val Lys Lys Ala Leu Cys Val Leu Val Gln His Asn Leu Val Ser 
    50                  55                  60                  


Tyr Gln Val His Lys Arg Gly Val Val Glu Tyr Glu Ala Gln Cys Ser 
65                  70                  75                  80  


Arg Val Leu Arg Met Leu Arg Tyr Pro Arg Tyr Ile Tyr Thr Thr Lys 
                85                  90                  95      


Thr Leu Tyr Ser Asp Thr Gly Glu Leu Ile Val Glu Glu Leu Leu Leu 
            100                 105                 110         


Asn Gly Lys Leu Thr Met Ser Ala Val Val Lys Lys Val Ala Asp Arg 
        115                 120                 125             


Leu Thr Glu Thr Met Glu Asp Gly Lys Thr Met Asp Tyr Ala Glu Val 
    130                 135                 140                 


Ser Asn Thr Phe Val Arg Leu Ala Asp Thr His Phe Val Gln Arg Cys 
145                 150                 155                 160 


Pro Ser Val Pro Thr Thr Glu Asn Ser Asp Pro Gly Pro Pro Pro Pro 
                165                 170                 175     


Ala Pro Thr Leu Val Ile Asn Glu Lys Asp Met Tyr Leu Val Pro Lys 
            180                 185                 190         


Leu Ser Leu Ile Gly Lys Gly Lys Arg Arg Arg Ser Ser Asp Glu Asp 
        195                 200                 205             


Ala Ala Gly Glu Pro Lys Ala Lys Arg Pro Lys Tyr Thr Thr Asp Asn 
    210                 215                 220                 


Lys Glu Pro Ile Pro Asp Asp Gly Ile Tyr Trp Gln Ala Asn Leu Asp 
225                 230                 235                 240 


Arg Phe His Gln His Phe Arg Asp Gln Ala Ile Val Ser Ala Val Ala 
                245                 250                 255     


Asn Arg Met Asp Gln Thr Ser Ser Glu Ile Val Arg Thr Met Leu Arg 
            260                 265                 270         


Met Ser Glu Ile Thr Thr Ser Ser Ser Ala Pro Phe Thr Gln Pro Leu 
        275                 280                 285             


Ser Ser Asn Glu Ile Phe Arg Ser Leu Pro Val Gly Tyr Asn Ile Ser 
    290                 295                 300                 


Lys Gln Val Leu Asp Gln Tyr Leu Thr Leu Leu Ala Asp Asp Pro Leu 
305                 310                 315                 320 


Glu Phe Val Gly Lys Ser Gly Asp Ser Gly Gly Gly Met Tyr Val Ile 
                325                 330                 335     


Asn Leu His Lys Ala Leu Ala Ser Leu Ala Thr Ala Thr Leu Glu Ser 
            340                 345                 350         


Val Val Gln Glu Arg Phe Gly Ser Arg Cys Ala Arg Ile Phe Arg Leu 
        355                 360                 365             


Val Leu Gln Lys Lys His Ile Glu Gln Lys Gln Val Glu Asp Phe Ala 
    370                 375                 380                 


Met Ile Pro Ala Lys Glu Ala Lys Asp Met Leu Tyr Lys Met Leu Ser 
385                 390                 395                 400 


Glu Asn Phe Met Ser Leu Gln Glu Ile Pro Lys Thr Pro Asp His Ala 
                405                 410                 415     


Pro Ser Arg Thr Phe Tyr Leu Tyr Thr Val Asn Ile Leu Ser Ala Ala 
            420                 425                 430         


Arg Met Leu Leu His Arg Cys Tyr Lys Ser Ile Ala Asn Leu Ile Glu 
        435                 440                 445             


Arg Arg Gln Phe Glu Thr Lys Glu Asn Lys Arg Leu Leu Glu Lys Ser 
    450                 455                 460                 


Gln Arg Val Glu Ala Ile Ile Ala Ser Met Gln Ala Thr Gly Ala Glu 
465                 470                 475                 480 


Glu Ala Gln Leu Gln Glu Ile Glu Glu Met Ile Thr Ala Pro Glu Arg 
                485                 490                 495     


Gln Gln Leu Glu Thr Leu Lys Arg Asn Val Asn Lys Leu Asp Ala Ser 
            500                 505                 510         


Glu Ile Gln Val Asp Glu Thr Ile Phe Leu Leu Glu Ser Tyr Ile Glu 
        515                 520                 525             


Cys Thr Met Lys Arg Gln 
    530                 


<210>  150
<211>  370
<212>  PRT
<213>  Homo sapiens

<400>  150

Met Pro Thr Glu Thr Leu Gln Thr Gly Ser Met Val Lys Pro Val Ser 
1               5                   10                  15      


Pro Ala Gly Thr Phe Thr Ser Ala Val Pro Leu Arg Ile Leu Asn Lys 
            20                  25                  30          


Gly Pro Asp Tyr Phe Arg Arg Gln Ala Glu Pro Asn Pro Lys Arg Leu 
        35                  40                  45              


Ser Ala Val Glu Arg Leu Glu Ala Asp Lys Ala Lys Tyr Val Lys Ser 
    50                  55                  60                  


Gln Glu Val Ile Asn Ala Lys Gln Glu Pro Val Lys Pro Ala Val Leu 
65                  70                  75                  80  


Ala Lys Pro Pro Val Cys Pro Ala Ala Lys Arg Ala Leu Gly Ser Pro 
                85                  90                  95      


Thr Leu Lys Val Phe Gly Asn His Ala Lys Thr Glu Ser Gly Val Gln 
            100                 105                 110         


Arg Glu Asn Leu Lys Leu Glu Ile Leu Lys Asn Ile Ile Asn Ser Ser 
        115                 120                 125             


Glu Gly Ser Ser Ser Gly Ser Gly His Lys His Ser Ser Arg Asn Trp 
    130                 135                 140                 


Pro Pro His Arg Ser Glu Ala Thr Asp Leu His Arg His Ser Phe Ala 
145                 150                 155                 160 


Glu Ser Leu Lys Val Tyr Pro Thr Gln Gly Arg Arg Ser Pro Gln Glu 
                165                 170                 175     


Gly Gly Ser His Val Gly Arg Arg Leu Leu Glu Gln Ser Ala Glu Ser 
            180                 185                 190         


Phe Leu His Val Ser His Ser Ser Ser Asp Ile Arg Lys Val Thr Ser 
        195                 200                 205             


Val Lys Pro Leu Lys Ala Ile Pro Cys Ser Ser Ser Ala Pro Pro Leu 
    210                 215                 220                 


Pro Pro Lys Pro Lys Ile Ala Ala Ile Ala Ser Met Lys Ser Pro Glu 
225                 230                 235                 240 


Ala Asp Pro Val Glu Pro Ala Cys Gly Val Ser Arg Arg Pro Ser Leu 
                245                 250                 255     


Gln Arg Ser Lys Ser Asp Leu Ser Asp Arg Tyr Phe Arg Val Asp Ala 
            260                 265                 270         


Asp Val Glu Arg Phe Phe Asn Tyr Cys Gly Leu Asp Pro Glu Glu Leu 
        275                 280                 285             


Glu Asn Leu Gly Met Glu Asn Phe Ala Arg Ala Asn Ser Asp Ile Ile 
    290                 295                 300                 


Ser Leu Asn Phe Arg Ser Ala Ser Met Ile Ser Ser Asp Cys Glu Gln 
305                 310                 315                 320 


Ser Gln Asp Ser Asn Ser Asp Leu Arg Asn Asp Asp Ser Ala Asn Asp 
                325                 330                 335     


Arg Val Pro Tyr Gly Ile Ser Ala Ile Glu Arg Asn Ala Arg Ile Ile 
            340                 345                 350         


Lys Trp Leu Tyr Ser Ile Lys Gln Ala Arg Glu Ser Gln Lys Val Ser 
        355                 360                 365             


His Val 
    370 


<210>  151
<211>  865
<212>  PRT
<213>  Homo sapiens

<400>  151

Met Leu Phe Thr Val Ser Cys Ser Lys Met Ser Ser Ile Val Asp Arg 
1               5                   10                  15      


Asp Asp Ser Ser Ile Phe Asp Gly Leu Val Glu Glu Asp Asp Lys Asp 
            20                  25                  30          


Lys Ala Lys Arg Val Ser Arg Asn Lys Ser Glu Lys Lys Arg Arg Asp 
        35                  40                  45              


Gln Phe Asn Val Leu Ile Lys Glu Leu Gly Ser Met Leu Pro Gly Asn 
    50                  55                  60                  


Ala Arg Lys Met Asp Lys Ser Thr Val Leu Gln Lys Ser Ile Asp Phe 
65                  70                  75                  80  


Leu Arg Lys His Lys Glu Ile Thr Ala Gln Ser Asp Ala Ser Glu Ile 
                85                  90                  95      


Arg Gln Asp Trp Lys Pro Thr Phe Leu Ser Asn Glu Glu Phe Thr Gln 
            100                 105                 110         


Leu Met Leu Glu Ala Leu Asp Gly Phe Phe Leu Ala Ile Met Thr Asp 
        115                 120                 125             


Gly Ser Ile Ile Tyr Val Ser Glu Ser Val Thr Ser Leu Leu Glu His 
    130                 135                 140                 


Leu Pro Ser Asp Leu Val Asp Gln Ser Val Phe Asn Phe Ile Pro Glu 
145                 150                 155                 160 


Gly Glu His Ser Glu Val Tyr Lys Ile Leu Ser Thr His Leu Leu Glu 
                165                 170                 175     


Ser Asp Ser Leu Thr Pro Glu Tyr Leu Lys Ser Lys Asn Gln Leu Glu 
            180                 185                 190         


Phe Cys Cys His Met Leu Arg Gly Thr Val Asp Pro Lys Glu Pro Ser 
        195                 200                 205             


Thr Tyr Glu Tyr Val Arg Phe Ile Gly Asn Phe Lys Ser Leu Asn Ser 
    210                 215                 220                 


Val Pro Thr Ser Ala His Asn Gly Phe Glu Gly Thr Ile Gln Arg Thr 
225                 230                 235                 240 


His Arg Pro Ser Tyr Glu Asp Arg Val Cys Phe Val Ala Thr Val Arg 
                245                 250                 255     


Leu Ala Thr Pro Gln Phe Ile Lys Glu Met Cys Thr Val Glu Glu Pro 
            260                 265                 270         


Asn Glu Glu Phe Thr Ser Arg His Ser Leu Glu Trp Lys Phe Leu Phe 
        275                 280                 285             


Leu Asp His Arg Ala Pro Pro Ile Ile Gly Tyr Leu Pro Phe Glu Val 
    290                 295                 300                 


Leu Gly Thr Ser Gly Tyr Asp Tyr Tyr His Val Asp Asp Leu Glu Asn 
305                 310                 315                 320 


Leu Ala Lys Cys His Glu His Leu Met Gln Tyr Gly Lys Gly Lys Ser 
                325                 330                 335     


Cys Tyr Tyr Arg Phe Leu Thr Lys Gly Gln Gln Trp Ile Trp Leu Gln 
            340                 345                 350         


Thr His Tyr Tyr Ile Thr Tyr His Gln Trp Asn Ser Arg Pro Glu Phe 
        355                 360                 365             


Ile Val Cys Thr His Thr Val Val Ser Tyr Ala Glu Val Arg Ala Glu 
    370                 375                 380                 


Arg Arg Arg Glu Leu Gly Ile Glu Glu Ser Leu Pro Asp Ala Ala Ala 
385                 390                 395                 400 


Asp Lys Ser Gln Asp Ser Gly Ser Asp Asn Arg Ile Asn Thr Val Ser 
                405                 410                 415     


Leu Lys Glu Ala Leu Glu Arg Phe Asp His Ser Pro Thr Pro Ser Ala 
            420                 425                 430         


Ser Ser Arg Ser Ser Arg Lys Ser Ser His Thr Ala Val Ser Asp Pro 
        435                 440                 445             


Ser Ser Thr Pro Thr Lys Ile Pro Thr Asp Thr Ser Thr Pro Pro Arg 
    450                 455                 460                 


Gln His Leu Pro Ala His Glu Lys Met Ala Gln Arg Arg Ser Ser Phe 
465                 470                 475                 480 


Ser Ser Gln Ser Met Asn Ser Gln Ser Val Gly Pro Ser Leu Thr Gln 
                485                 490                 495     


Pro Val Met Ser Gln Ala Ala Asn Leu Pro Val Pro Gln Gly Met Ser 
            500                 505                 510         


Gln Phe Gln Phe Ser Ala Gln Leu Gly Ala Met Gln His Leu Lys Asp 
        515                 520                 525             


Gln Leu Glu Gln Arg Thr Arg Met Ile Glu Ala Asn Ile His Arg Gln 
    530                 535                 540                 


Gln Glu Glu Leu Arg Lys Ile Gln Glu Gln Leu Gln Met Val His Gly 
545                 550                 555                 560 


Gln Gly Leu Gln Met Phe Leu Gln Gln Ser Asn Pro Gly Leu Asn Phe 
                565                 570                 575     


Gly Ser Val Gln Leu Ser Ser Gly Asn Ser Ser Asn Ile Gln Gln Leu 
            580                 585                 590         


Thr Pro Ile Asn Met Gln Gly Gln Val Val Pro Thr Asn Gln Ile Gln 
        595                 600                 605             


Ser Gly Met Asn Ala Gly His Ile Gly Thr Ser Gln His Leu Ile Gln 
    610                 615                 620                 


Gln Gln Ser Leu Gln Ser Thr Ser Thr Gln Gln Ser Gln Gln Ser Val 
625                 630                 635                 640 


Met Ser Gly His Ser Gln Gln Thr Ser Leu Ala Ser Gln Thr Gln Ser 
                645                 650                 655     


Thr Leu Thr Ala Pro Leu Tyr Asn Thr Met Val Ile Ser Gln Pro Ala 
            660                 665                 670         


Pro Gly Ser Met Val Gln Ile Pro Ser Ser Met Pro Gln Asn Ser Thr 
        675                 680                 685             


Gln Ser Ala Thr Val Thr Thr Phe Thr Gln Asp Arg Gln Ile Arg Phe 
    690                 695                 700                 


Ser Gln Gly Gln Gln Leu Val Thr Lys Leu Val Thr Ala Pro Val Ala 
705                 710                 715                 720 


Cys Gly Ala Val Met Val Pro Ser Thr Met Leu Met Gly Gln Val Val 
                725                 730                 735     


Thr Ala Tyr Pro Thr Phe Ala Thr Gln Gln Gln Gln Ala Gln Thr Leu 
            740                 745                 750         


Ser Val Thr Gln Gln Gln Pro Gln Gln Gln Gln Pro Gln Gln Gln Gln 
        755                 760                 765             


Pro Gln Gln Gln Gln Pro Gln Gln Gln Gln Gln Ser Ser Gln Glu Gln 
    770                 775                 780                 


Gln Leu Pro Ser Val Pro Gln Pro Ser Gln Ala Gln Leu Thr Gln Ser 
785                 790                 795                 800 


Pro Gln Gln Phe Leu Gln Thr Ser Arg Leu Leu His Gly Asn Pro Ser 
                805                 810                 815     


Thr Gln Leu Ile Leu Ser Ala Ala Phe Pro Leu Gln Gln Ser Thr Phe 
            820                 825                 830         


Pro Pro Ser His His Gln Gln His Gln Ser Gln Gln Gln Gln Gln Leu 
        835                 840                 845             


Ser Arg His Arg Thr Asp Ser Leu Thr Asp Pro Ser Lys Val Gln Pro 
    850                 855                 860                 


Gln 
865 


<210>  152
<211>  579
<212>  PRT
<213>  Homo sapiens

<400>  152

Met Ser Ala Ala Ile Ala Ala Leu Ala Ala Ser Tyr Gly Ser Gly Ser 
1               5                   10                  15      


Gly Ser Glu Ser Asp Ser Asp Ser Glu Ser Ser Arg Cys Pro Leu Pro 
            20                  25                  30          


Ala Ala Asp Ser Leu Met His Leu Thr Lys Ser Pro Ser Ser Lys Pro 
        35                  40                  45              


Ser Leu Ala Val Ala Val Asp Ser Ala Pro Glu Val Ala Val Lys Glu 
    50                  55                  60                  


Asp Leu Glu Thr Gly Val His Leu Asp Pro Ala Val Lys Glu Val Gln 
65                  70                  75                  80  


Tyr Asn Pro Thr Tyr Glu Thr Met Phe Ala Pro Glu Phe Gly Pro Glu 
                85                  90                  95      


Asn Pro Phe Arg Thr Gln Gln Met Ala Ala Pro Arg Asn Met Leu Ser 
            100                 105                 110         


Gly Tyr Ala Glu Pro Ala His Ile Asn Asp Phe Met Phe Glu Gln Gln 
        115                 120                 125             


Arg Arg Thr Phe Ala Thr Tyr Gly Tyr Ala Leu Asp Pro Ser Leu Asp 
    130                 135                 140                 


Asn His Gln Val Ser Ala Lys Tyr Ile Gly Ser Val Glu Glu Ala Glu 
145                 150                 155                 160 


Lys Asn Gln Gly Leu Thr Val Phe Glu Thr Gly Gln Lys Lys Thr Glu 
                165                 170                 175     


Lys Arg Lys Lys Phe Lys Glu Asn Asp Ala Ser Asn Ile Asp Gly Phe 
            180                 185                 190         


Leu Gly Pro Trp Ala Lys Tyr Val Asp Glu Lys Asp Val Ala Lys Pro 
        195                 200                 205             


Ser Glu Glu Glu Gln Lys Glu Leu Asp Glu Ile Thr Ala Lys Arg Gln 
    210                 215                 220                 


Lys Lys Gly Lys Gln Glu Glu Glu Lys Pro Gly Glu Glu Lys Thr Ile 
225                 230                 235                 240 


Leu His Val Lys Glu Met Tyr Asp Tyr Gln Gly Arg Ser Tyr Leu His 
                245                 250                 255     


Ile Pro Gln Asp Val Gly Val Asn Leu Arg Ser Thr Met Pro Pro Glu 
            260                 265                 270         


Lys Cys Tyr Leu Pro Lys Lys Gln Ile His Val Trp Ser Gly His Thr 
        275                 280                 285             


Lys Gly Val Ser Ala Val Arg Leu Phe Pro Leu Ser Gly His Leu Leu 
    290                 295                 300                 


Leu Ser Cys Ser Met Asp Cys Lys Ile Lys Leu Trp Glu Val Tyr Gly 
305                 310                 315                 320 


Glu Arg Arg Cys Leu Arg Thr Phe Ile Gly His Ser Lys Ala Val Arg 
                325                 330                 335     


Asp Ile Cys Phe Asn Thr Ala Gly Thr Gln Phe Leu Ser Ala Ala Tyr 
            340                 345                 350         


Asp Arg Tyr Leu Lys Leu Trp Asp Thr Glu Thr Gly Gln Cys Ile Ser 
        355                 360                 365             


Arg Phe Thr Asn Arg Lys Val Pro Tyr Cys Val Lys Phe Asn Pro Asp 
    370                 375                 380                 


Glu Asp Lys Gln Asn Leu Phe Val Ala Gly Met Ser Asp Lys Lys Ile 
385                 390                 395                 400 


Val Gln Trp Asp Ile Arg Ser Gly Glu Ile Val Gln Glu Tyr Asp Arg 
                405                 410                 415     


His Leu Gly Ala Val Asn Thr Ile Val Phe Val Asp Glu Asn Arg Arg 
            420                 425                 430         


Phe Val Ser Thr Ser Asp Asp Lys Ser Leu Arg Val Trp Glu Trp Asp 
        435                 440                 445             


Ile Pro Val Asp Phe Lys Tyr Ile Ala Glu Pro Ser Met His Ser Met 
    450                 455                 460                 


Pro Ala Val Thr Leu Ser Pro Asn Gly Lys Trp Leu Ala Cys Gln Ser 
465                 470                 475                 480 


Met Asp Asn Gln Ile Leu Ile Phe Gly Ala Gln Asn Arg Phe Arg Leu 
                485                 490                 495     


Asn Lys Lys Lys Ile Phe Lys Gly His Met Val Ala Gly Tyr Ala Cys 
            500                 505                 510         


Gln Val Asp Phe Ser Pro Asp Met Ser Tyr Val Ile Ser Gly Asp Gly 
        515                 520                 525             


Asn Gly Lys Leu Asn Ile Trp Asp Trp Lys Thr Thr Lys Leu Tyr Ser 
    530                 535                 540                 


Arg Phe Lys Ala His Asp Lys Val Cys Ile Gly Ala Val Trp His Pro 
545                 550                 555                 560 


His Glu Thr Ser Lys Val Ile Thr Cys Gly Trp Asp Gly Leu Ile Lys 
                565                 570                 575     


Leu Trp Asp 
            


<210>  153
<211>  205
<212>  PRT
<213>  Homo sapiens

<400>  153

Met Ala Ala Ala Arg Pro Ser Leu Gly Arg Val Leu Pro Gly Ser Ser 
1               5                   10                  15      


Val Leu Phe Leu Cys Asp Met Gln Glu Lys Phe Arg His Asn Ile Ala 
            20                  25                  30          


Tyr Phe Pro Gln Ile Val Ser Val Ala Ala Arg Met Leu Lys Val Ala 
        35                  40                  45              


Arg Leu Leu Glu Val Pro Val Met Leu Thr Glu Gln Tyr Pro Gln Gly 
    50                  55                  60                  


Leu Gly Pro Thr Val Pro Glu Leu Gly Thr Glu Gly Leu Arg Pro Leu 
65                  70                  75                  80  


Ala Lys Thr Cys Phe Ser Met Val Pro Ala Leu Gln Gln Glu Leu Asp 
                85                  90                  95      


Ser Arg Pro Gln Leu Arg Ser Val Leu Leu Cys Gly Ile Glu Ala Gln 
            100                 105                 110         


Ala Cys Ile Leu Asn Thr Thr Leu Asp Leu Leu Asp Arg Gly Leu Gln 
        115                 120                 125             


Val His Val Val Val Asp Ala Cys Ser Ser Arg Ser Gln Val Asp Arg 
    130                 135                 140                 


Leu Val Ala Leu Ala Arg Met Arg Gln Ser Gly Ala Phe Leu Ser Thr 
145                 150                 155                 160 


Ser Glu Gly Leu Ile Leu Gln Leu Val Gly Asp Ala Val His Pro Gln 
                165                 170                 175     


Phe Lys Glu Ile Gln Lys Leu Ile Lys Glu Pro Ala Pro Asp Ser Gly 
            180                 185                 190         


Leu Leu Gly Leu Phe Gln Gly Gln Asn Ser Leu Leu His 
        195                 200                 205 


<210>  154
<211>  739
<212>  PRT
<213>  Homo sapiens

<400>  154

Met Ala Pro Gln Lys His Gly Gly Gly Gly Gly Gly Gly Ser Gly Pro 
1               5                   10                  15      


Ser Ala Gly Ser Gly Gly Gly Gly Phe Gly Gly Ser Ala Ala Val Ala 
            20                  25                  30          


Ala Ala Thr Ala Ser Gly Gly Lys Ser Gly Gly Gly Ser Cys Gly Gly 
        35                  40                  45              


Gly Gly Ser Tyr Ser Ala Ser Ser Ser Ser Ser Ala Ala Ala Ala Ala 
    50                  55                  60                  


Gly Ala Ala Val Leu Pro Val Lys Lys Pro Lys Met Glu His Val Gln 
65                  70                  75                  80  


Ala Asp His Glu Leu Phe Leu Gln Ala Phe Glu Lys Pro Thr Gln Ile 
                85                  90                  95      


Tyr Arg Phe Leu Arg Thr Arg Asn Leu Ile Ala Pro Ile Phe Leu His 
            100                 105                 110         


Arg Thr Leu Thr Tyr Met Ser His Arg Asn Ser Arg Thr Asn Ile Lys 
        115                 120                 125             


Arg Lys Thr Phe Lys Val Asp Asp Met Leu Ser Lys Val Glu Lys Met 
    130                 135                 140                 


Lys Gly Glu Gln Glu Ser His Ser Leu Ser Ala His Leu Gln Leu Thr 
145                 150                 155                 160 


Phe Thr Gly Phe Phe His Lys Asn Asp Lys Pro Ser Pro Asn Ser Glu 
                165                 170                 175     


Asn Glu Gln Asn Ser Val Thr Leu Glu Val Leu Leu Val Lys Val Cys 
            180                 185                 190         


His Lys Lys Arg Lys Asp Val Ser Cys Pro Ile Arg Gln Val Pro Thr 
        195                 200                 205             


Gly Lys Lys Gln Val Pro Leu Asn Pro Asp Leu Asn Gln Thr Lys Pro 
    210                 215                 220                 


Gly Asn Phe Pro Ser Leu Ala Val Ser Ser Asn Glu Phe Glu Pro Ser 
225                 230                 235                 240 


Asn Ser His Met Val Lys Ser Tyr Ser Leu Leu Phe Arg Val Thr Arg 
                245                 250                 255     


Pro Gly Arg Arg Glu Phe Asn Gly Met Ile Asn Gly Glu Thr Asn Glu 
            260                 265                 270         


Asn Ile Asp Val Asn Glu Glu Leu Pro Ala Arg Arg Lys Arg Asn Arg 
        275                 280                 285             


Glu Asp Gly Glu Lys Thr Phe Val Ala Gln Met Thr Val Phe Asp Lys 
    290                 295                 300                 


Asn Arg Arg Leu Gln Leu Leu Asp Gly Glu Tyr Glu Val Ala Met Gln 
305                 310                 315                 320 


Glu Met Glu Glu Cys Pro Ile Ser Lys Lys Arg Ala Thr Trp Glu Thr 
                325                 330                 335     


Ile Leu Asp Gly Lys Arg Leu Pro Pro Phe Glu Thr Phe Ser Gln Gly 
            340                 345                 350         


Pro Thr Leu Gln Phe Thr Leu Arg Trp Thr Gly Glu Thr Asn Asp Lys 
        355                 360                 365             


Ser Thr Ala Pro Ile Ala Lys Pro Leu Ala Thr Arg Asn Ser Glu Ser 
    370                 375                 380                 


Leu His Gln Glu Asn Lys Pro Gly Ser Val Lys Pro Thr Gln Thr Ile 
385                 390                 395                 400 


Ala Val Lys Glu Ser Leu Thr Thr Asp Leu Gln Thr Arg Lys Glu Lys 
                405                 410                 415     


Asp Thr Pro Asn Glu Asn Arg Gln Lys Leu Arg Ile Phe Tyr Gln Phe 
            420                 425                 430         


Leu Tyr Asn Asn Asn Thr Arg Gln Gln Thr Glu Ala Arg Asp Asp Leu 
        435                 440                 445             


His Cys Pro Trp Cys Thr Leu Asn Cys Arg Lys Leu Tyr Ser Leu Leu 
    450                 455                 460                 


Lys His Leu Lys Leu Cys His Ser Arg Phe Ile Phe Asn Tyr Val Tyr 
465                 470                 475                 480 


His Pro Lys Gly Ala Arg Ile Asp Val Ser Ile Asn Glu Cys Tyr Asp 
                485                 490                 495     


Gly Ser Tyr Ala Gly Asn Pro Gln Asp Ile His Arg Gln Pro Gly Phe 
            500                 505                 510         


Ala Phe Ser Arg Asn Gly Pro Val Lys Arg Thr Pro Ile Thr His Ile 
        515                 520                 525             


Leu Val Cys Arg Pro Lys Arg Thr Lys Ala Ser Met Ser Glu Phe Leu 
    530                 535                 540                 


Glu Ser Glu Asp Gly Glu Val Glu Gln Gln Arg Thr Tyr Ser Ser Gly 
545                 550                 555                 560 


His Asn Arg Leu Tyr Phe His Ser Asp Thr Cys Leu Pro Leu Arg Pro 
                565                 570                 575     


Gln Glu Met Glu Val Asp Ser Glu Asp Glu Lys Asp Pro Glu Trp Leu 
            580                 585                 590         


Arg Glu Lys Thr Ile Thr Gln Ile Glu Glu Phe Ser Asp Val Asn Glu 
        595                 600                 605             


Gly Glu Lys Glu Val Met Lys Leu Trp Asn Leu His Val Met Lys His 
    610                 615                 620                 


Gly Phe Ile Ala Asp Asn Gln Met Asn His Ala Cys Met Leu Phe Val 
625                 630                 635                 640 


Glu Asn Tyr Gly Gln Lys Ile Ile Lys Lys Asn Leu Cys Arg Asn Phe 
                645                 650                 655     


Met Leu His Leu Val Ser Met His Asp Phe Asn Leu Ile Ser Ile Met 
            660                 665                 670         


Ser Ile Asp Lys Ala Val Thr Lys Leu Arg Glu Met Gln Gln Lys Leu 
        675                 680                 685             


Glu Lys Gly Glu Ser Ala Ser Pro Ala Asn Glu Glu Ile Thr Glu Glu 
    690                 695                 700                 


Gln Asn Gly Thr Ala Asn Gly Phe Ser Glu Ile Asn Ser Lys Glu Lys 
705                 710                 715                 720 


Ala Leu Glu Thr Asp Ser Val Ser Gly Val Ser Lys Gln Ser Lys Lys 
                725                 730                 735     


Gln Lys Leu 
            


<210>  155
<211>  381
<212>  PRT
<213>  Homo sapiens

<400>  155

Met Arg Ser His Thr Ile Thr Met Thr Thr Thr Ser Val Ser Ser Trp 
1               5                   10                  15      


Pro Tyr Ser Ser His Arg Met Arg Phe Ile Thr Asn His Ser Asp Gln 
            20                  25                  30          


Pro Pro Gln Asn Phe Ser Ala Thr Pro Asn Val Thr Thr Cys Pro Met 
        35                  40                  45              


Asp Glu Lys Leu Leu Ser Thr Val Leu Thr Thr Ser Tyr Ser Val Ile 
    50                  55                  60                  


Phe Ile Val Gly Leu Val Gly Asn Ile Ile Ala Leu Tyr Val Phe Leu 
65                  70                  75                  80  


Gly Ile His Arg Lys Arg Asn Ser Ile Gln Ile Tyr Leu Leu Asn Val 
                85                  90                  95      


Ala Ile Ala Asp Leu Leu Leu Ile Phe Cys Leu Pro Phe Arg Ile Met 
            100                 105                 110         


Tyr His Ile Asn Gln Asn Lys Trp Thr Leu Gly Val Ile Leu Cys Lys 
        115                 120                 125             


Val Val Gly Thr Leu Phe Tyr Met Asn Met Tyr Ile Ser Ile Ile Leu 
    130                 135                 140                 


Leu Gly Phe Ile Ser Leu Asp Arg Tyr Ile Lys Ile Asn Arg Ser Ile 
145                 150                 155                 160 


Gln Gln Arg Lys Ala Ile Thr Thr Lys Gln Ser Ile Tyr Val Cys Cys 
                165                 170                 175     


Ile Val Trp Met Leu Ala Leu Gly Gly Phe Leu Thr Met Ile Ile Leu 
            180                 185                 190         


Thr Leu Lys Lys Gly Gly His Asn Ser Thr Met Cys Phe His Tyr Arg 
        195                 200                 205             


Asp Lys His Asn Ala Lys Gly Glu Ala Ile Phe Asn Phe Ile Leu Val 
    210                 215                 220                 


Val Met Phe Trp Leu Ile Phe Leu Leu Ile Ile Leu Ser Tyr Ile Lys 
225                 230                 235                 240 


Ile Gly Lys Asn Leu Leu Arg Ile Ser Lys Arg Arg Ser Lys Phe Pro 
                245                 250                 255     


Asn Ser Gly Lys Tyr Ala Thr Thr Ala Arg Asn Ser Phe Ile Val Leu 
            260                 265                 270         


Ile Ile Phe Thr Ile Cys Phe Val Pro Tyr His Ala Phe Arg Phe Ile 
        275                 280                 285             


Tyr Ile Ser Ser Gln Leu Asn Val Ser Ser Cys Tyr Trp Lys Glu Ile 
    290                 295                 300                 


Val His Lys Thr Asn Glu Ile Met Leu Val Leu Ser Ser Phe Asn Ser 
305                 310                 315                 320 


Cys Leu Asp Pro Val Met Tyr Phe Leu Met Ser Ser Asn Ile Arg Lys 
                325                 330                 335     


Ile Met Cys Gln Leu Leu Phe Arg Arg Phe Gln Gly Glu Pro Ser Arg 
            340                 345                 350         


Ser Glu Ser Thr Ser Glu Phe Lys Pro Gly Tyr Ser Leu His Asp Thr 
        355                 360                 365             


Ser Val Ala Val Lys Ile Gln Ser Ser Ser Lys Ser Thr 
    370                 375                 380     


<210>  156
<211>  235
<212>  PRT
<213>  Homo sapiens

<400>  156

Met Ala Val Glu Leu Gly Val Leu Leu Val Arg Pro Arg Pro Gly Thr 
1               5                   10                  15      


Gly Leu Gly Arg Val Met Arg Thr Leu Leu Leu Val Leu Trp Leu Ala 
            20                  25                  30          


Thr Arg Gly Ser Ala Leu Tyr Phe His Ile Gly Glu Thr Glu Lys Lys 
        35                  40                  45              


Cys Phe Ile Glu Glu Ile Pro Asp Glu Thr Met Val Ile Gly Asn Tyr 
    50                  55                  60                  


Arg Thr Gln Leu Tyr Asp Lys Gln Arg Glu Glu Tyr Gln Pro Ala Thr 
65                  70                  75                  80  


Pro Gly Leu Gly Met Phe Val Glu Val Lys Asp Pro Glu Asp Lys Val 
                85                  90                  95      


Ile Leu Ala Arg Gln Tyr Gly Ser Glu Gly Arg Phe Thr Phe Thr Ser 
            100                 105                 110         


His Thr Pro Gly Glu His Gln Ile Cys Leu His Ser Asn Ser Thr Lys 
        115                 120                 125             


Phe Ser Leu Phe Ala Gly Gly Met Leu Arg Val His Leu Asp Ile Gln 
    130                 135                 140                 


Val Gly Glu His Ala Asn Asp Tyr Ala Glu Ile Ala Ala Lys Asp Lys 
145                 150                 155                 160 


Leu Ser Glu Leu Gln Leu Arg Val Arg Gln Leu Val Glu Gln Val Glu 
                165                 170                 175     


Gln Ile Gln Lys Glu Gln Asn Tyr Gln Arg Trp Arg Glu Glu Arg Phe 
            180                 185                 190         


Arg Gln Thr Ser Glu Ser Thr Asn Gln Arg Val Leu Trp Trp Ser Ile 
        195                 200                 205             


Leu Gln Thr Leu Ile Leu Val Ala Ile Gly Val Trp Gln Met Arg His 
    210                 215                 220                 


Leu Lys Ser Phe Phe Glu Ala Lys Lys Leu Val 
225                 230                 235 


<210>  157
<211>  1364
<212>  PRT
<213>  Homo sapiens

<400>  157

Met Ala Glu Leu Lys Val Glu Ala Pro Ala Ser Val Asp Trp Gln Lys 
1               5                   10                  15      


Arg Cys Leu Thr Leu Glu Thr Gln Leu Phe Arg Phe Arg Leu Gln Ala 
            20                  25                  30          


Ser Lys Ile Arg Glu Leu Leu Ala Asp Lys Met Gln Glu Leu Glu Gln 
        35                  40                  45              


Arg Leu Leu Glu Ala Glu Gln Arg Ala Glu Asn Ala Glu Thr Gln Val 
    50                  55                  60                  


Gly Val Met Glu Glu Lys Val Lys Leu Ser Asn Leu Lys Asn Val Asp 
65                  70                  75                  80  


Ser Glu Gly Ser Leu His Arg Lys Tyr Gln Glu Leu Leu Lys Ala Ile 
                85                  90                  95      


Lys Gly Lys Asp Glu Leu Ile Ser Gln Leu Glu Ala Gln Leu Glu Lys 
            100                 105                 110         


Gln Lys Gln Met Arg Ala Glu Glu Ala Lys Thr Val Gln Glu Lys Ala 
        115                 120                 125             


Ala Lys Ile Lys Glu Trp Val Thr Leu Lys Leu Ala Lys Leu Glu Met 
    130                 135                 140                 


Glu Asn Gln His Leu Lys Ser His Asn Gln Arg Leu Val Glu Gln Val 
145                 150                 155                 160 


Gly Ser Leu Gln Asp Ala Leu Glu Ala Ile Gln Ile Ala Pro Ser Arg 
                165                 170                 175     


Lys Leu Leu Val Pro Pro Tyr Gly Ala Ala Glu Gln Asp Ser Val Pro 
            180                 185                 190         


Ser Glu Pro Gly Ile Gln Pro Met Gly Gln Asp Ser Gly Ser Gln Ala 
        195                 200                 205             


Gln Gly Leu Lys Ala Ala Val Leu Ala Pro Ser Pro Gly Ala Leu Gln 
    210                 215                 220                 


Ser Lys Asp Ser Val Ser Glu Ala Ala Ser Pro Leu Glu Asp Ser Ser 
225                 230                 235                 240 


Ser Ser Thr Val His Ser Gly Glu Thr Val Glu Ala Lys Pro Leu Gln 
                245                 250                 255     


Pro His Leu Gly Arg Glu Ser Pro Pro His Gln Pro Cys Met Lys Leu 
            260                 265                 270         


Leu Thr Phe Arg Cys Ser Ser Ala Ser Trp Gly Glu Gly Leu Val Thr 
        275                 280                 285             


Ala Gln Arg Gly Met Leu Pro Gly Thr Lys Thr Ser Ala Arg Glu Gly 
    290                 295                 300                 


Gly Pro Gly Ser Ser Leu Thr Leu Pro Lys Val Arg Ala Pro Gly Thr 
305                 310                 315                 320 


Pro Arg Asp Ser Ile Gln Leu Ala Lys Arg His His Ser Gln Pro Gln 
                325                 330                 335     


Val Gly His Gly His Phe Gly Arg Val Val Asn Ile Glu Thr Glu Ala 
            340                 345                 350         


Phe Ser Ala Leu His Pro Ser Gly Leu Pro Glu Leu Glu Ser Arg Ala 
        355                 360                 365             


Arg Ser Arg Glu Glu Pro Glu Lys Met Glu Met Glu Glu Pro Pro Pro 
    370                 375                 380                 


Ala Gly Lys Asn Glu Glu Arg Glu Ser Pro Lys Ala Leu Gly Ala Glu 
385                 390                 395                 400 


Leu Glu Glu Val Glu Leu Gly Asn Lys Pro Pro Thr Pro Pro Leu His 
                405                 410                 415     


Gln Phe Ser Ser Trp Glu Ser Arg Ile Tyr Ala Val Ala Thr Ser Gly 
            420                 425                 430         


Met Arg Leu Ser Asp Met Ser Pro Arg Ser Asn Thr Ala Cys Cys Ala 
        435                 440                 445             


Ser Ser Pro Pro Ala Leu Val Ser Pro Gly Ser Phe Ser Gly Leu Val 
    450                 455                 460                 


Tyr Lys Asn Val Thr Val Pro Val Tyr Thr Ala Leu Lys Gly Arg Ala 
465                 470                 475                 480 


Thr Gln Ile Ser Asn Met Pro Phe Met Asp Glu Ser Ser Gly Ser Asp 
                485                 490                 495     


Asp Asp Cys Ser Ser Gln Ala Ser Phe Arg Ile Ser Val Pro Ser Ser 
            500                 505                 510         


Glu Ser Arg Lys Thr Ser Gly Leu Gly Ser Pro Arg Ala Ile Lys Arg 
        515                 520                 525             


Gly Val Ser Met Ser Ser Leu Ser Ser Glu Gly Asp Tyr Ala Ile Pro 
    530                 535                 540                 


Pro Asp Ala Cys Ser Leu Asp Ser Asp Tyr Ser Glu Pro Glu His Lys 
545                 550                 555                 560 


Leu Gln Arg Thr Ser Ser Tyr Ser Thr Asp Gly Leu Gly Leu Gly Gly 
                565                 570                 575     


Glu Ser Leu Glu Lys Ser Gly Tyr Leu Leu Lys Met Gly Ser Gln Val 
            580                 585                 590         


Lys Thr Trp Lys Arg Arg Trp Phe Val Leu Arg Gln Gly Gln Ile Met 
        595                 600                 605             


Tyr Tyr Lys Ser Pro Ser Asp Val Ile Arg Lys Pro Gln Gly Gln Val 
    610                 615                 620                 


Asp Leu Asn Ser Arg Cys Gln Ile Val Arg Gly Glu Gly Ser Gln Thr 
625                 630                 635                 640 


Phe Gln Leu Ile Ser Glu Lys Lys Thr Tyr Tyr Leu Thr Ala Asp Ser 
                645                 650                 655     


Pro Ser Leu Leu Glu Glu Trp Ile Arg Val Leu Gln Ser Leu Leu Lys 
            660                 665                 670         


Val Gln Ala Thr Gly Pro Pro Ala Leu Leu Arg Gly Gly Thr Lys Pro 
        675                 680                 685             


Thr Val Lys Gly Trp Leu Thr Lys Val Lys His Gly His Ser Lys Val 
    690                 695                 700                 


Val Trp Cys Ala Leu Val Gly Lys Ile Phe Tyr Tyr Tyr Arg Ser His 
705                 710                 715                 720 


Glu Asp Lys Arg Pro Leu Gly Cys Leu Pro Val Arg Asp Ala His Ile 
                725                 730                 735     


Glu Glu Val Asp Arg Ser Cys Asp Ser Asp Glu Asp Tyr Glu Ala Gly 
            740                 745                 750         


Gly Thr Arg Arg Leu Leu Ser Ser His Cys Thr Leu Val Ile His Pro 
        755                 760                 765             


Thr Glu His Ser Pro Thr Tyr Leu Leu Ile Gly Thr Lys His Glu Lys 
    770                 775                 780                 


Asp Thr Trp Leu Tyr His Leu Thr Val Ala Ala Gly Gly Ser Ser Ala 
785                 790                 795                 800 


Lys Val Gly Thr Ala Tyr Glu Gln Leu Ile Gly Lys Leu Met Asp Gly 
                805                 810                 815     


Glu Gly Asp Pro Asp Ser Pro Leu Trp Arg His Pro Met Leu Cys Tyr 
            820                 825                 830         


Ser Lys Asp Gly Leu Tyr Ala Ser Leu Thr Thr Leu Pro Ser Glu Ala 
        835                 840                 845             


Leu Gln Thr Glu Ala Leu Lys Leu Phe Lys Ser Cys Gln Leu Phe Ile 
    850                 855                 860                 


Asn Val Pro Val Glu Ala Ala Ser Val Asp Tyr His Val Ser Leu Ala 
865                 870                 875                 880 


Gln Thr Ala Leu Gln Val Cys Leu Val His Pro Glu Leu Gln Ser Glu 
                885                 890                 895     


Ile Tyr Cys Gln Leu Met Lys Gln Thr Ser Cys Arg Pro Pro Gln Lys 
            900                 905                 910         


Tyr Ser Leu Met Gln Cys Trp Gln Leu Leu Ala Leu Cys Ala Pro Leu 
        915                 920                 925             


Phe Leu Pro Gln His His Phe Leu Trp Tyr Val Lys Gln Gln Leu Gln 
    930                 935                 940                 


Arg His Ala Asp Pro Arg Ser Glu Thr Gly Gln Tyr Ala Thr Tyr Cys 
945                 950                 955                 960 


Gln Arg Ala Val Glu Arg Thr Leu Arg Thr Gly Glu Arg Glu Ala Arg 
                965                 970                 975     


Pro Ser Arg Met Glu Val Val Ser Ile Leu Leu Arg Asn Pro Phe His 
            980                 985                 990         


His Ser Leu Pro Phe Ser Ile Pro  Val His Phe Thr Asn  Gly Thr Tyr 
        995                 1000                 1005             


His Val  Val Gly Phe Asp Gly  Ser Ser Thr Val Asp  Glu Phe Leu 
    1010                 1015                 1020             


Gln Arg  Leu Asn Gln Glu Ile  Gly Met Arg Lys Pro  Ser His Ser 
    1025                 1030                 1035             


Gly Phe  Ala Leu Phe Thr Asp  Asp Pro Ser Gly Arg  Asp Leu Glu 
    1040                 1045                 1050             


His Cys  Leu Gln Gly Ser Val  Lys Ile Cys Asp Ala  Ile Ser Lys 
    1055                 1060                 1065             


Trp Glu  Gln Ala Met Lys Glu  Leu His Pro Gly Lys  Ser Glu Gly 
    1070                 1075                 1080             


Gly Thr  Arg Val Val Lys Leu  Met Tyr Lys Asn Arg  Leu Tyr Phe 
    1085                 1090                 1095             


Arg Ser  Gln Val Lys Gly Glu  Thr Asp Arg Glu Arg  Leu Leu Leu 
    1100                 1105                 1110             


Ala Ser  Gln Thr Ser Arg Glu  Ile Val Ala Gly Arg  Phe Pro Ile 
    1115                 1120                 1125             


Asn Lys  Glu Leu Ala Leu Glu  Met Ala Ala Leu Met  Ala Gln Val 
    1130                 1135                 1140             


Glu Tyr  Gly Asp Leu Glu Lys  Pro Ala Leu Pro Gly  Pro Gly Gly 
    1145                 1150                 1155             


Thr Ser  Pro Ala Lys Ala Gln  His Leu Leu Gln Gln  Val Leu Asp 
    1160                 1165                 1170             


Arg Phe  His Pro Arg Arg Tyr  Arg His Gly Ala Pro  Ala Glu Gln 
    1175                 1180                 1185             


Leu Arg  His Leu Ala Asp Met  Leu Thr Thr Lys Trp  Ala Thr Leu 
    1190                 1195                 1200             


Gln Gly  Cys Ser Pro Pro Glu  Cys Ile Arg Ile Tyr  Leu Thr Val 
    1205                 1210                 1215             


Ala Arg  Lys Trp Pro Phe Phe  Gly Ala Lys Leu Phe  Ala Ala Gln 
    1220                 1225                 1230             


Pro Ala  Gln Leu Ser Ser Lys  Glu Asn Ala Leu Val  Trp Ile Ala 
    1235                 1240                 1245             


Val Asn  Glu Asp Gly Val Ser  Ile Leu Asp His Asn  Thr Met Gln 
    1250                 1255                 1260             


Val His  Ile Thr Tyr Pro Tyr  Ser Ser Val Thr Thr  Phe Gly Gly 
    1265                 1270                 1275             


Cys Arg  Asp Asp Phe Met Leu  Val Ile Arg Ser Ile  Pro Asp Lys 
    1280                 1285                 1290             


Ser Ser  Gly Lys Ser His Ile  Glu Lys Leu Ile Phe  Arg Met Ala 
    1295                 1300                 1305             


Ala Pro  Lys Ile Ala Glu Ala  Thr Phe Ile Met Ala  Ser Tyr Met 
    1310                 1315                 1320             


Asn His  Cys Thr Thr Thr Val  Asn Pro Pro Thr Asn  Pro Pro Gly 
    1325                 1330                 1335             


Ala Cys  Gln Leu Trp Glu Leu  Asp Gly Arg Gln Phe  Phe Ser Ser 
    1340                 1345                 1350             


Val Ser  Cys Ala Thr Lys Gly  Pro Thr Leu Leu 
    1355                 1360                 


<210>  158
<211>  435
<212>  PRT
<213>  Homo sapiens

<400>  158

Met Ala Gln Ala Val Trp Ser Arg Leu Gly Arg Ile Leu Trp Leu Ala 
1               5                   10                  15      


Cys Leu Leu Pro Trp Ala Pro Ala Gly Val Ala Ala Gly Leu Tyr Glu 
            20                  25                  30          


Leu Asn Leu Thr Thr Asp Ser Pro Ala Thr Thr Gly Ala Val Val Thr 
        35                  40                  45              


Ile Ser Ala Ser Leu Val Ala Lys Asp Asn Gly Ser Leu Ala Leu Pro 
    50                  55                  60                  


Ala Asp Ala His Leu Tyr Arg Phe His Trp Ile His Thr Pro Leu Val 
65                  70                  75                  80  


Leu Thr Gly Lys Met Glu Lys Gly Leu Ser Ser Thr Ile Arg Val Val 
                85                  90                  95      


Gly His Val Pro Gly Glu Phe Pro Val Ser Val Trp Val Thr Ala Ala 
            100                 105                 110         


Asp Cys Trp Met Cys Gln Pro Val Ala Arg Gly Phe Val Val Leu Pro 
        115                 120                 125             


Ile Thr Glu Phe Leu Val Gly Asp Leu Val Val Thr Gln Asn Thr Ser 
    130                 135                 140                 


Leu Pro Trp Pro Ser Ser Tyr Leu Thr Lys Thr Val Leu Lys Val Ser 
145                 150                 155                 160 


Phe Leu Leu His Asp Pro Ser Asn Phe Leu Lys Thr Ala Leu Phe Leu 
                165                 170                 175     


Tyr Ser Trp Asp Phe Gly Asp Gly Thr Gln Met Val Thr Glu Asp Ser 
            180                 185                 190         


Val Val Tyr Tyr Asn Tyr Ser Ile Ile Gly Thr Phe Thr Val Lys Leu 
        195                 200                 205             


Lys Val Val Ala Glu Trp Glu Glu Val Glu Pro Asp Ala Thr Arg Ala 
    210                 215                 220                 


Val Lys Gln Lys Thr Gly Asp Phe Ser Ala Ser Leu Lys Leu Gln Glu 
225                 230                 235                 240 


Thr Leu Arg Gly Ile Gln Val Leu Gly Pro Thr Leu Ile Gln Thr Phe 
                245                 250                 255     


Gln Lys Met Thr Val Thr Leu Asn Phe Leu Gly Ser Pro Pro Leu Thr 
            260                 265                 270         


Val Cys Trp Arg Leu Lys Pro Glu Cys Leu Pro Leu Glu Glu Gly Glu 
        275                 280                 285             


Cys His Pro Val Ser Val Ala Ser Thr Ala Tyr Asn Leu Thr His Thr 
    290                 295                 300                 


Phe Arg Asp Pro Gly Asp Tyr Cys Phe Ser Ile Arg Ala Glu Asn Ile 
305                 310                 315                 320 


Ile Ser Lys Thr His Gln Tyr His Lys Ile Gln Val Trp Pro Ser Arg 
                325                 330                 335     


Ile Gln Pro Ala Val Phe Ala Phe Pro Cys Ala Thr Leu Ile Thr Val 
            340                 345                 350         


Met Leu Ala Phe Ile Met Tyr Met Thr Leu Arg Asn Ala Thr Gln Gln 
        355                 360                 365             


Lys Asp Met Val Glu Val Ala Asp Phe Asp Phe Ser Pro Met Ser Asp 
    370                 375                 380                 


Lys Asn Pro Glu Pro Pro Ser Gly Val Arg Cys Cys Cys Gln Met Cys 
385                 390                 395                 400 


Cys Gly Pro Phe Leu Leu Glu Thr Pro Ser Glu Tyr Leu Glu Ile Val 
                405                 410                 415     


Arg Glu Asn His Gly Leu Leu Pro Pro Leu Tyr Lys Ser Val Lys Thr 
            420                 425                 430         


Tyr Thr Val 
        435 


<210>  159
<211>  1079
<212>  PRT
<213>  Homo sapiens

<400>  159

Met Val Cys Ser Ala Ala Pro Leu Leu Leu Leu Ala Thr Thr Leu Pro 
1               5                   10                  15      


Leu Leu Gly Ser Pro Val Ala Gln Ala Ser Gln Pro Val Ser Glu Thr 
            20                  25                  30          


Gly Val Arg Pro Arg Glu Gly Leu Gln Arg Arg Gln Trp Gly Pro Leu 
        35                  40                  45              


Ile Gly Arg Asp Lys Ala Trp Asn Glu Arg Ile Asp Arg Pro Phe Pro 
    50                  55                  60                  


Ala Cys Pro Ile Pro Leu Ser Ser Ser Phe Gly Arg Trp Pro Lys Gly 
65                  70                  75                  80  


Gln Thr Met Trp Ala Gln Thr Ser Thr Leu Thr Leu Thr Glu Glu Glu 
                85                  90                  95      


Leu Gly Gln Ser Gln Ala Gly Gly Glu Ser Gly Ser Gly Gln Leu Leu 
            100                 105                 110         


Asp Gln Glu Asn Gly Ala Gly Glu Ser Ala Leu Val Ser Val Tyr Val 
        115                 120                 125             


His Leu Asp Phe Pro Asp Lys Thr Trp Pro Pro Glu Leu Ser Arg Thr 
    130                 135                 140                 


Leu Thr Leu Pro Ala Ala Ser Ala Ser Ser Ser Pro Arg Pro Leu Leu 
145                 150                 155                 160 


Thr Gly Leu Arg Leu Thr Thr Glu Cys Asn Val Asn His Lys Gly Asn 
                165                 170                 175     


Phe Tyr Cys Ala Cys Leu Ser Gly Tyr Gln Trp Asn Thr Ser Ile Cys 
            180                 185                 190         


Leu His Tyr Pro Pro Cys Gln Ser Leu His Asn His Gln Pro Cys Gly 
        195                 200                 205             


Cys Leu Val Phe Ser His Pro Glu Pro Gly Tyr Cys Gln Leu Leu Pro 
    210                 215                 220                 


Pro Gly Ser Pro Val Thr Cys Leu Pro Ala Val Pro Gly Ile Leu Asn 
225                 230                 235                 240 


Leu Asn Ser Gln Leu Gln Met Pro Gly Asp Thr Leu Ser Leu Thr Leu 
                245                 250                 255     


His Leu Ser Gln Glu Ala Thr Asn Leu Ser Trp Phe Leu Arg His Pro 
            260                 265                 270         


Gly Ser Pro Ser Pro Ile Leu Leu Gln Pro Gly Thr Gln Val Ser Val 
        275                 280                 285             


Thr Ser Ser His Gly Gln Ala Ala Leu Ser Val Ser Asn Met Ser His 
    290                 295                 300                 


His Trp Ala Gly Glu Tyr Met Ser Cys Phe Glu Ala Gln Gly Phe Lys 
305                 310                 315                 320 


Trp Asn Leu Tyr Glu Val Val Arg Val Pro Leu Lys Ala Thr Asp Val 
                325                 330                 335     


Ala Arg Leu Pro Tyr Gln Leu Ser Ile Ser Cys Ala Thr Ser Pro Gly 
            340                 345                 350         


Phe Gln Leu Ser Cys Cys Ile Pro Ser Thr Asn Leu Ala Tyr Thr Ala 
        355                 360                 365             


Ala Trp Ser Pro Gly Glu Gly Ser Lys Ala Ser Ser Phe Asn Glu Ser 
    370                 375                 380                 


Gly Ser Gln Cys Phe Val Leu Ala Val Gln Arg Cys Pro Met Ala Asp 
385                 390                 395                 400 


Thr Thr Tyr Ala Cys Asp Leu Gln Ser Leu Gly Leu Ala Pro Leu Arg 
                405                 410                 415     


Val Pro Ile Ser Ile Thr Ile Ile Gln Asp Gly Asp Ile Thr Cys Pro 
            420                 425                 430         


Glu Asp Ala Ser Val Leu Thr Trp Asn Val Thr Lys Ala Gly His Val 
        435                 440                 445             


Ala Gln Ala Pro Cys Pro Glu Ser Lys Arg Gly Ile Val Arg Arg Leu 
    450                 455                 460                 


Cys Gly Ala Asp Gly Val Trp Gly Pro Val His Ser Ser Cys Thr Asp 
465                 470                 475                 480 


Ala Arg Leu Leu Ala Leu Phe Thr Arg Thr Lys Leu Leu Gln Ala Gly 
                485                 490                 495     


Gln Gly Ser Pro Ala Glu Glu Val Pro Gln Ile Leu Ala Gln Leu Pro 
            500                 505                 510         


Gly Gln Ala Ala Glu Ala Ser Ser Pro Ser Asp Leu Leu Thr Leu Leu 
        515                 520                 525             


Ser Thr Met Lys Tyr Val Ala Lys Val Val Ala Glu Ala Arg Ile Gln 
    530                 535                 540                 


Leu Asp Arg Arg Ala Leu Lys Asn Leu Leu Ile Ala Thr Asp Lys Val 
545                 550                 555                 560 


Leu Asp Met Asp Thr Arg Ser Leu Trp Thr Leu Ala Gln Ala Arg Lys 
                565                 570                 575     


Pro Trp Ala Gly Ser Thr Leu Leu Leu Ala Val Glu Thr Leu Ala Cys 
            580                 585                 590         


Ser Leu Cys Pro Gln Asp His Pro Phe Ala Phe Ser Leu Pro Asn Val 
        595                 600                 605             


Leu Leu Gln Ser Gln Leu Phe Gly Pro Thr Phe Pro Ala Asp Tyr Ser 
    610                 615                 620                 


Ile Ser Phe Pro Thr Arg Pro Pro Leu Gln Ala Gln Ile Pro Arg His 
625                 630                 635                 640 


Ser Leu Ala Pro Leu Val Arg Asn Gly Thr Glu Ile Ser Ile Thr Ser 
                645                 650                 655     


Leu Val Leu Arg Lys Leu Asp His Leu Leu Pro Ser Asn Tyr Gly Gln 
            660                 665                 670         


Gly Leu Gly Asp Ser Leu Tyr Ala Thr Pro Gly Leu Val Leu Val Ile 
        675                 680                 685             


Ser Ile Met Ala Gly Asp Arg Ala Phe Ser Gln Gly Glu Val Ile Met 
    690                 695                 700                 


Asp Phe Gly Asn Thr Asp Gly Ser Pro His Cys Val Phe Trp Asp His 
705                 710                 715                 720 


Ser Leu Phe Gln Gly Arg Gly Gly Trp Ser Lys Glu Gly Cys Gln Ala 
                725                 730                 735     


Gln Val Ala Ser Ala Ser Pro Thr Ala Gln Cys Leu Cys Gln His Leu 
            740                 745                 750         


Thr Ala Phe Ser Val Leu Met Ser Pro His Thr Val Pro Glu Glu Pro 
        755                 760                 765             


Ala Leu Ala Leu Leu Thr Gln Val Gly Leu Gly Ala Ser Ile Leu Ala 
    770                 775                 780                 


Leu Leu Val Cys Leu Gly Val Tyr Trp Leu Val Trp Arg Val Val Val 
785                 790                 795                 800 


Arg Asn Lys Ile Ser Tyr Phe Arg His Ala Ala Leu Leu Asn Met Val 
                805                 810                 815     


Phe Cys Leu Leu Ala Ala Asp Thr Cys Phe Leu Gly Ala Pro Phe Leu 
            820                 825                 830         


Ser Pro Gly Pro Arg Ser Pro Leu Cys Leu Ala Ala Ala Phe Leu Cys 
        835                 840                 845             


His Phe Leu Tyr Leu Ala Thr Phe Phe Trp Met Leu Ala Gln Ala Leu 
    850                 855                 860                 


Val Leu Ala His Gln Leu Leu Phe Val Phe His Gln Leu Ala Lys His 
865                 870                 875                 880 


Arg Val Leu Pro Leu Met Val Leu Leu Gly Tyr Leu Cys Pro Leu Gly 
                885                 890                 895     


Leu Ala Gly Val Thr Leu Gly Leu Tyr Leu Pro Gln Gly Gln Tyr Leu 
            900                 905                 910         


Arg Glu Gly Glu Cys Trp Leu Asp Gly Lys Gly Gly Ala Leu Tyr Thr 
        915                 920                 925             


Phe Val Gly Pro Val Leu Ala Ile Ile Gly Val Asn Gly Leu Val Leu 
    930                 935                 940                 


Ala Met Ala Met Leu Lys Leu Leu Arg Pro Ser Leu Ser Glu Gly Pro 
945                 950                 955                 960 


Pro Ala Glu Lys Arg Gln Ala Leu Leu Gly Val Ile Lys Ala Leu Leu 
                965                 970                 975     


Ile Leu Thr Pro Ile Phe Gly Leu Thr Trp Gly Leu Gly Leu Ala Thr 
            980                 985                 990         


Leu Leu Glu Glu Val Ser Thr Val  Pro His Tyr Ile Phe  Thr Ile Leu 
        995                 1000                 1005             


Asn Thr  Leu Gln Gly Val Phe  Ile Leu Leu Phe Gly  Cys Leu Met 
    1010                 1015                 1020             


Asp Arg  Lys Ile Gln Glu Ala  Leu Arg Lys Arg Phe  Cys Arg Ala 
    1025                 1030                 1035             


Gln Ala  Pro Ser Ser Thr Ile  Ser Leu Val Ser Cys  Cys Leu Gln 
    1040                 1045                 1050             


Ile Leu  Ser Cys Ala Ser Lys  Ser Met Ser Glu Gly  Ile Pro Trp 
    1055                 1060                 1065             


Pro Ser  Ser Glu Asp Met Gly  Thr Ala Arg Ser 
    1070                 1075                 


<210>  160
<211>  1461
<212>  PRT
<213>  Homo sapiens

<400>  160

Met Ala Ala Gly Gly Gly Gly Gly Ser Ser Lys Ala Ser Ser Ser Ser 
1               5                   10                  15      


Ala Ser Ser Ala Gly Ala Leu Glu Ser Ser Leu Asp Arg Lys Phe Gln 
            20                  25                  30          


Ser Val Thr Asn Thr Met Glu Ser Ile Gln Gly Leu Ser Ser Trp Cys 
        35                  40                  45              


Ile Glu Asn Lys Lys His His Ser Thr Ile Val Tyr His Trp Met Lys 
    50                  55                  60                  


Trp Leu Arg Arg Ser Ala Tyr Pro His Arg Leu Asn Leu Phe Tyr Leu 
65                  70                  75                  80  


Ala Asn Asp Val Ile Gln Asn Cys Lys Arg Lys Asn Ala Ile Ile Phe 
                85                  90                  95      


Arg Glu Ser Phe Ala Asp Val Leu Pro Glu Ala Ala Ala Leu Val Lys 
            100                 105                 110         


Asp Pro Ser Val Ser Lys Ser Val Glu Arg Ile Phe Lys Ile Trp Glu 
        115                 120                 125             


Asp Arg Asn Val Tyr Pro Glu Glu Met Ile Val Ala Leu Arg Glu Ala 
    130                 135                 140                 


Leu Ser Thr Thr Phe Lys Thr Gln Lys Gln Leu Lys Glu Asn Leu Asn 
145                 150                 155                 160 


Lys Gln Pro Asn Lys Gln Trp Lys Lys Ser Gln Thr Ser Thr Asn Pro 
                165                 170                 175     


Lys Ala Ala Leu Lys Ser Lys Ile Val Ala Glu Phe Arg Ser Gln Ala 
            180                 185                 190         


Leu Ile Glu Glu Leu Leu Leu Tyr Lys Arg Ser Glu Asp Gln Ile Glu 
        195                 200                 205             


Leu Lys Glu Lys Gln Leu Ser Thr Met Arg Val Asp Val Cys Ser Thr 
    210                 215                 220                 


Glu Thr Leu Lys Cys Leu Lys Asp Lys Thr Gly Gly Lys Lys Phe Ser 
225                 230                 235                 240 


Lys Glu Phe Glu Glu Ala Ser Ser Lys Leu Glu Glu Phe Val Asn Gly 
                245                 250                 255     


Leu Asp Lys Gln Val Lys Asn Gly Pro Ser Leu Thr Glu Ala Leu Glu 
            260                 265                 270         


Asn Ala Gly Ile Phe Tyr Glu Ala Gln Tyr Lys Glu Val Lys Val Val 
        275                 280                 285             


Ala Asn Ala Tyr Lys Thr Phe Ala Asn Arg Val Asn Asn Leu Lys Lys 
    290                 295                 300                 


Lys Leu Asp Gln Leu Lys Ser Thr Leu Pro Asp Pro Glu Glu Ser Pro 
305                 310                 315                 320 


Val Pro Ser Pro Ser Met Asp Ala Pro Ser Pro Thr Gly Ser Glu Ser 
                325                 330                 335     


Pro Phe Gln Gly Met Gly Gly Glu Glu Ser Gln Ser Pro Thr Met Glu 
            340                 345                 350         


Ser Glu Lys Ser Ala Thr Pro Glu Pro Val Thr Asp Asn Arg Asp Val 
        355                 360                 365             


Glu Asp Met Glu Leu Ser Asp Val Glu Asp Asp Gly Ser Lys Ile Ile 
    370                 375                 380                 


Val Glu Asp Arg Lys Glu Lys Pro Ala Glu Lys Ser Ala Val Ser Thr 
385                 390                 395                 400 


Ser Val Pro Thr Lys Pro Thr Glu Asn Ile Ser Lys Ala Ser Ser Cys 
                405                 410                 415     


Thr Pro Val Pro Val Thr Met Thr Ala Thr Pro Pro Leu Pro Lys Pro 
            420                 425                 430         


Val Asn Thr Ser Leu Ser Pro Ser Pro Ala Leu Ala Leu Pro Asn Leu 
        435                 440                 445             


Ala Asn Val Asp Leu Ala Lys Ile Ser Ser Ile Leu Ser Ser Leu Thr 
    450                 455                 460                 


Ser Val Met Lys Asn Thr Gly Val Ser Pro Ala Ser Arg Pro Ser Pro 
465                 470                 475                 480 


Gly Thr Pro Thr Ser Pro Ser Asn Leu Thr Ser Gly Leu Lys Thr Pro 
                485                 490                 495     


Ala Pro Ala Thr Thr Thr Ser His Asn Pro Leu Ala Asn Ile Leu Ser 
            500                 505                 510         


Lys Val Glu Ile Thr Pro Glu Ser Ile Leu Ser Ala Leu Ser Lys Thr 
        515                 520                 525             


Gln Thr Gln Ser Ala Pro Ala Leu Gln Gly Leu Ser Ser Leu Leu Gln 
    530                 535                 540                 


Ser Val Thr Gly Asn Pro Val Pro Ala Ser Glu Ala Ala Ser Gln Ser 
545                 550                 555                 560 


Thr Ser Ala Ser Pro Ala Asn Thr Thr Val Ser Thr Ile Lys Gly Arg 
                565                 570                 575     


Asn Leu Pro Ser Ser Ala Gln Pro Phe Ile Pro Lys Ser Phe Asn Tyr 
            580                 585                 590         


Ser Pro Asn Ser Ser Thr Ser Glu Val Ser Ser Thr Ser Ala Ser Lys 
        595                 600                 605             


Ala Ser Ile Gly Gln Ser Pro Gly Leu Pro Ser Thr Thr Phe Lys Leu 
    610                 615                 620                 


Pro Ser Asn Ser Leu Gly Phe Thr Ala Thr His Asn Thr Ser Pro Ala 
625                 630                 635                 640 


Ala Pro Pro Thr Glu Val Thr Ile Cys Gln Ser Ser Glu Val Ser Lys 
                645                 650                 655     


Pro Lys Leu Glu Ser Glu Ser Thr Ser Pro Ser Leu Glu Met Lys Ile 
            660                 665                 670         


His Asn Phe Leu Lys Gly Asn Pro Gly Phe Ser Gly Leu Asn Leu Asn 
        675                 680                 685             


Ile Pro Ile Leu Ser Ser Leu Gly Ser Ser Ala Pro Ser Glu Ser His 
    690                 695                 700                 


Pro Ser Asp Phe Gln Arg Gly Pro Thr Ser Thr Ser Ile Asp Asn Ile 
705                 710                 715                 720 


Asp Gly Thr Pro Val Arg Asp Glu Arg Ser Gly Thr Pro Thr Gln Asp 
                725                 730                 735     


Glu Met Met Asp Lys Pro Thr Ser Ser Ser Val Asp Thr Met Ser Leu 
            740                 745                 750         


Leu Ser Lys Ile Ile Ser Pro Gly Ser Ser Thr Pro Ser Ser Thr Arg 
        755                 760                 765             


Ser Pro Pro Pro Gly Arg Asp Glu Ser Tyr Pro Arg Glu Leu Ser Asn 
    770                 775                 780                 


Ser Val Ser Thr Tyr Arg Pro Phe Gly Leu Gly Ser Glu Ser Pro Tyr 
785                 790                 795                 800 


Lys Gln Pro Ser Asp Gly Met Glu Arg Pro Ser Ser Leu Met Asp Ser 
                805                 810                 815     


Ser Gln Glu Lys Phe Tyr Pro Asp Thr Ser Phe Gln Glu Asp Glu Asp 
            820                 825                 830         


Tyr Arg Asp Phe Glu Tyr Ser Gly Pro Pro Pro Ser Ala Met Met Asn 
        835                 840                 845             


Leu Glu Lys Lys Pro Ala Lys Ser Ile Leu Lys Ser Ser Lys Leu Ser 
    850                 855                 860                 


Asp Thr Thr Glu Tyr Gln Pro Ile Leu Ser Ser Tyr Ser His Arg Ala 
865                 870                 875                 880 


Gln Glu Phe Gly Val Lys Ser Ala Phe Pro Pro Ser Val Arg Ala Leu 
                885                 890                 895     


Leu Asp Ser Ser Glu Asn Cys Asp Arg Leu Ser Ser Ser Pro Gly Leu 
            900                 905                 910         


Phe Gly Ala Phe Ser Val Arg Gly Asn Glu Pro Gly Ser Asp Arg Ser 
        915                 920                 925             


Pro Ser Pro Ser Lys Asn Asp Ser Phe Phe Thr Pro Asp Ser Asn His 
    930                 935                 940                 


Asn Ser Leu Ser Gln Ser Thr Thr Gly His Leu Ser Leu Pro Gln Lys 
945                 950                 955                 960 


Gln Tyr Pro Asp Ser Pro His Pro Val Pro His Arg Ser Leu Phe Ser 
                965                 970                 975     


Pro Gln Asn Thr Leu Ala Ala Pro Thr Gly His Pro Pro Thr Ser Gly 
            980                 985                 990         


Val Glu Lys Val Leu Ala Ser Thr  Ile Ser Thr Thr Ser  Thr Ile Glu 
        995                 1000                 1005             


Phe Lys  Asn Met Leu Lys Asn  Ala Ser Arg Lys Pro  Ser Asp Asp 
    1010                 1015                 1020             


Lys His  Phe Gly Gln Ala Pro  Ser Lys Gly Thr Pro  Ser Asp Gly 
    1025                 1030                 1035             


Val Ser  Leu Ser Asn Leu Thr  Gln Pro Ser Leu Thr  Ala Thr Asp 
    1040                 1045                 1050             


Gln Gln  Gln Gln Glu Glu His  Tyr Arg Ile Glu Thr  Arg Val Ser 
    1055                 1060                 1065             


Ser Ser  Cys Leu Asp Leu Pro  Asp Ser Thr Glu Glu  Lys Gly Ala 
    1070                 1075                 1080             


Pro Ile  Glu Thr Leu Gly Tyr  His Ser Ala Ser Asn  Arg Arg Met 
    1085                 1090                 1095             


Ser Gly  Glu Pro Ile Gln Thr  Val Glu Ser Ile Arg  Val Pro Gly 
    1100                 1105                 1110             


Lys Gly  Asn Arg Gly His Gly  Arg Glu Ala Ser Arg  Val Gly Trp 
    1115                 1120                 1125             


Phe Asp  Leu Ser Thr Ser Gly  Ser Ser Phe Asp Asn  Gly Pro Ser 
    1130                 1135                 1140             


Ser Ala  Ser Glu Leu Ala Ser  Leu Gly Gly Gly Gly  Ser Gly Gly 
    1145                 1150                 1155             


Leu Thr  Gly Phe Lys Thr Ala  Pro Tyr Lys Glu Arg  Ala Pro Gln 
    1160                 1165                 1170             


Phe Gln  Glu Ser Val Gly Ser  Phe Arg Ser Asn Ser  Phe Asn Ser 
    1175                 1180                 1185             


Thr Phe  Glu His His Leu Pro  Pro Ser Pro Leu Glu  His Gly Thr 
    1190                 1195                 1200             


Pro Phe  Gln Arg Glu Pro Val  Gly Pro Ser Ser Ala  Pro Pro Val 
    1205                 1210                 1215             


Pro Pro  Lys Asp His Gly Gly  Ile Phe Ser Arg Asp  Ala Pro Thr 
    1220                 1225                 1230             


His Leu  Pro Ser Val Asp Leu  Ser Asn Pro Phe Thr  Lys Glu Ala 
    1235                 1240                 1245             


Ala Leu  Ala His Ala Ala Pro  Pro Pro Pro Pro Gly  Glu His Ser 
    1250                 1255                 1260             


Gly Ile  Pro Phe Pro Thr Pro  Pro Pro Pro Pro Pro  Pro Gly Glu 
    1265                 1270                 1275             


His Ser  Ser Ser Gly Gly Ser  Gly Val Pro Phe Ser  Thr Pro Pro 
    1280                 1285                 1290             


Pro Pro  Pro Pro Pro Val Asp  His Ser Gly Val Val  Pro Phe Pro 
    1295                 1300                 1305             


Ala Pro  Pro Leu Ala Glu His  Gly Val Ala Gly Ala  Val Ala Val 
    1310                 1315                 1320             


Phe Pro  Lys Asp His Ser Ser  Leu Leu Gln Gly Thr  Leu Ala Glu 
    1325                 1330                 1335             


His Phe  Gly Val Leu Pro Gly  Pro Arg Asp His Gly  Gly Pro Thr 
    1340                 1345                 1350             


Gln Arg  Asp Leu Asn Gly Pro  Gly Leu Ser Arg Val  Arg Glu Ser 
    1355                 1360                 1365             


Leu Thr  Leu Pro Ser His Ser  Leu Glu His Leu Gly  Pro Pro His 
    1370                 1375                 1380             


Gly Gly  Gly Gly Gly Gly Gly  Ser Asn Ser Ser Ser  Gly Pro Pro 
    1385                 1390                 1395             


Leu Gly  Pro Ser His Arg Asp  Thr Ile Ser Arg Ser  Gly Ile Ile 
    1400                 1405                 1410             


Leu Arg  Ser Pro Arg Pro Asp  Phe Arg Pro Arg Glu  Pro Phe Leu 
    1415                 1420                 1425             


Ser Arg  Asp Pro Phe His Ser  Leu Lys Arg Pro Arg  Pro Pro Phe 
    1430                 1435                 1440             


Ala Arg  Gly Pro Pro Phe Phe  Ala Pro Lys Arg Pro  Phe Phe Pro 
    1445                 1450                 1455             


Pro Arg  Tyr 
    1460     


<210>  161
<211>  643
<212>  PRT
<213>  Homo sapiens

<400>  161

Met Gly Leu Leu Pro Lys Leu Gly Ala Ser Gln Gly Ser Asp Thr Ser 
1               5                   10                  15      


Thr Ser Arg Ala Gly Arg Cys Ala Arg Ser Val Phe Gly Asn Ile Lys 
            20                  25                  30          


Val Phe Val Leu Cys Gln Gly Leu Leu Gln Leu Cys Gln Leu Leu Tyr 
        35                  40                  45              


Ser Ala Tyr Phe Lys Ser Ser Leu Thr Thr Ile Glu Lys Arg Phe Gly 
    50                  55                  60                  


Leu Ser Ser Ser Ser Ser Gly Leu Ile Ser Ser Leu Asn Glu Ile Ser 
65                  70                  75                  80  


Asn Ala Ile Leu Ile Ile Phe Val Ser Tyr Phe Gly Ser Arg Val His 
                85                  90                  95      


Arg Pro Arg Leu Ile Gly Ile Gly Gly Leu Phe Leu Ala Ala Gly Ala 
            100                 105                 110         


Phe Ile Leu Thr Leu Pro His Phe Leu Ser Glu Pro Tyr Gln Tyr Thr 
        115                 120                 125             


Leu Ala Ser Thr Gly Asn Asn Ser Arg Leu Gln Ala Glu Leu Cys Gln 
    130                 135                 140                 


Lys His Trp Gln Asp Leu Pro Pro Ser Lys Cys His Ser Thr Thr Gln 
145                 150                 155                 160 


Asn Pro Gln Lys Glu Thr Ser Ser Met Trp Gly Leu Met Val Val Ala 
                165                 170                 175     


Gln Leu Leu Ala Gly Ile Gly Thr Val Pro Ile Gln Pro Phe Gly Ile 
            180                 185                 190         


Ser Tyr Val Asp Asp Phe Ser Glu Pro Ser Asn Ser Pro Leu Tyr Ile 
        195                 200                 205             


Ser Ile Leu Phe Ala Ile Ser Val Phe Gly Pro Ala Phe Gly Tyr Leu 
    210                 215                 220                 


Leu Gly Ser Val Met Leu Gln Ile Phe Val Asp Tyr Gly Arg Val Asn 
225                 230                 235                 240 


Thr Ala Ala Val Asn Leu Val Pro Gly Asp Pro Arg Trp Ile Gly Ala 
                245                 250                 255     


Trp Trp Leu Gly Leu Leu Ile Ser Ser Ala Leu Leu Val Leu Thr Ser 
            260                 265                 270         


Phe Pro Phe Phe Phe Phe Pro Arg Ala Met Pro Ile Gly Ala Lys Arg 
        275                 280                 285             


Ala Pro Ala Thr Ala Asp Glu Ala Arg Lys Leu Glu Glu Ala Lys Ser 
    290                 295                 300                 


Arg Gly Ser Leu Val Asp Phe Ile Lys Arg Phe Pro Cys Ile Phe Leu 
305                 310                 315                 320 


Arg Leu Leu Met Asn Ser Leu Phe Val Leu Val Val Leu Ala Gln Cys 
                325                 330                 335     


Thr Phe Ser Ser Val Ile Ala Gly Leu Ser Thr Phe Leu Asn Lys Phe 
            340                 345                 350         


Leu Glu Lys Gln Tyr Gly Thr Ser Ala Ala Tyr Ala Asn Phe Leu Ile 
        355                 360                 365             


Gly Ala Val Asn Leu Pro Ala Ala Ala Leu Gly Met Leu Phe Gly Gly 
    370                 375                 380                 


Ile Leu Met Lys Arg Phe Val Phe Ser Leu Gln Ala Ile Pro Arg Ile 
385                 390                 395                 400 


Ala Thr Thr Ile Ile Thr Ile Ser Met Ile Leu Cys Val Pro Leu Phe 
                405                 410                 415     


Phe Met Gly Cys Ser Thr Pro Thr Val Ala Glu Val Tyr Pro Pro Ser 
            420                 425                 430         


Thr Ser Ser Ser Ile His Pro Gln Ser Pro Ala Cys Arg Arg Asp Cys 
        435                 440                 445             


Ser Cys Pro Asp Ser Ile Phe His Pro Val Cys Gly Asp Asn Gly Ile 
    450                 455                 460                 


Glu Tyr Leu Ser Pro Cys His Ala Gly Cys Ser Asn Ile Asn Met Ser 
465                 470                 475                 480 


Ser Ala Thr Ser Lys Gln Leu Ile Tyr Leu Asn Cys Ser Cys Val Thr 
                485                 490                 495     


Gly Gly Ser Ala Ser Ala Lys Thr Gly Ser Cys Pro Val Pro Cys Ala 
            500                 505                 510         


His Phe Leu Leu Pro Ala Ile Phe Leu Ile Ser Phe Val Ser Leu Ile 
        515                 520                 525             


Ala Cys Ile Ser His Asn Pro Leu Tyr Met Met Val Leu Arg Val Val 
    530                 535                 540                 


Asn Gln Glu Glu Lys Ser Phe Ala Ile Gly Val Gln Phe Leu Leu Met 
545                 550                 555                 560 


Arg Leu Leu Ala Trp Leu Pro Ser Pro Ala Leu Tyr Gly Leu Thr Ile 
                565                 570                 575     


Asp His Ser Cys Ile Arg Trp Asn Ser Leu Cys Leu Gly Arg Arg Gly 
            580                 585                 590         


Ala Cys Ala Tyr Tyr Asp Asn Asp Ala Leu Arg Asp Arg Tyr Leu Gly 
        595                 600                 605             


Leu Gln Met Gly Tyr Lys Ala Leu Gly Met Leu Leu Leu Cys Phe Ile 
    610                 615                 620                 


Ser Trp Arg Val Lys Lys Asn Lys Glu Tyr Asn Val Gln Lys Ala Ala 
625                 630                 635                 640 


Gly Leu Ile 
            


<210>  162
<211>  1057
<212>  PRT
<213>  Homo sapiens

<400>  162

Met Leu Cys Trp Gly Asn Ala Ser Phe Gly Gln Leu Gly Leu Gly Gly 
1               5                   10                  15      


Ile Asp Glu Glu Ile Val Leu Glu Pro Arg Lys Ser Asp Phe Phe Ile 
            20                  25                  30          


Asn Lys Arg Val Arg Asp Val Gly Cys Gly Leu Arg His Thr Val Phe 
        35                  40                  45              


Val Leu Asp Asp Gly Thr Val Tyr Thr Cys Gly Cys Asn Asp Leu Gly 
    50                  55                  60                  


Gln Leu Gly His Glu Lys Ser Arg Lys Lys Pro Glu Gln Val Val Ala 
65                  70                  75                  80  


Leu Asp Ala Gln Asn Ile Val Ala Val Ser Cys Gly Glu Ala His Thr 
                85                  90                  95      


Leu Ala Leu Asn Asp Lys Gly Gln Val Tyr Ala Trp Gly Leu Asp Ser 
            100                 105                 110         


Asp Gly Gln Leu Gly Leu Val Gly Ser Glu Glu Cys Ile Arg Val Pro 
        115                 120                 125             


Arg Asn Ile Lys Ser Leu Ser Asp Ile Gln Ile Val Gln Val Ala Cys 
    130                 135                 140                 


Gly Tyr Tyr His Ser Leu Ala Leu Ser Lys Ala Ser Glu Val Phe Cys 
145                 150                 155                 160 


Trp Gly Gln Asn Lys Tyr Gly Gln Leu Gly Leu Gly Thr Asp Cys Lys 
                165                 170                 175     


Lys Gln Thr Ser Pro Gln Leu Leu Lys Ser Leu Leu Gly Ile Pro Phe 
            180                 185                 190         


Met Gln Val Ala Ala Gly Gly Ala His Ser Phe Val Leu Thr Leu Ser 
        195                 200                 205             


Gly Ala Ile Phe Gly Trp Gly Arg Asn Lys Phe Gly Gln Leu Gly Leu 
    210                 215                 220                 


Asn Asp Glu Asn Asp Arg Tyr Val Pro Asn Leu Leu Lys Ser Leu Arg 
225                 230                 235                 240 


Ser Gln Lys Ile Val Tyr Ile Cys Cys Gly Glu Asp His Thr Ala Ala 
                245                 250                 255     


Leu Thr Lys Glu Gly Gly Val Phe Thr Phe Gly Ala Gly Gly Tyr Gly 
            260                 265                 270         


Gln Leu Gly His Asn Ser Thr Ser His Glu Ile Asn Pro Arg Lys Val 
        275                 280                 285             


Phe Glu Leu Met Gly Ser Ile Val Thr Glu Ile Ala Cys Gly Arg Gln 
    290                 295                 300                 


His Thr Ser Ala Phe Val Pro Ser Ser Gly Arg Ile Tyr Ser Phe Gly 
305                 310                 315                 320 


Leu Gly Gly Asn Gly Gln Leu Gly Thr Gly Ser Thr Ser Asn Arg Lys 
                325                 330                 335     


Ser Pro Phe Thr Val Lys Gly Asn Trp Tyr Pro Tyr Asn Gly Gln Cys 
            340                 345                 350         


Leu Pro Asp Ile Asp Ser Glu Glu Tyr Phe Cys Val Lys Arg Ile Phe 
        355                 360                 365             


Ser Gly Gly Asp Gln Ser Phe Ser His Tyr Ser Ser Pro Gln Asn Cys 
    370                 375                 380                 


Gly Pro Pro Asp Asp Phe Arg Cys Pro Asn Pro Thr Lys Gln Ile Trp 
385                 390                 395                 400 


Thr Val Asn Glu Ala Leu Ile Gln Lys Trp Leu Ser Tyr Pro Ser Gly 
                405                 410                 415     


Arg Phe Pro Val Glu Ile Ala Asn Glu Ile Asp Gly Thr Phe Ser Ser 
            420                 425                 430         


Ser Gly Cys Leu Asn Gly Ser Phe Leu Ala Val Ser Asn Asp Asp His 
        435                 440                 445             


Tyr Arg Thr Gly Thr Arg Phe Ser Gly Val Asp Met Asn Ala Ala Arg 
    450                 455                 460                 


Leu Leu Phe His Lys Leu Ile Gln Pro Asp His Pro Gln Ile Ser Gln 
465                 470                 475                 480 


Gln Val Ala Ala Ser Leu Glu Lys Asn Leu Ile Pro Lys Leu Thr Ser 
                485                 490                 495     


Ser Leu Pro Asp Val Glu Ala Leu Arg Phe Tyr Leu Thr Leu Pro Glu 
            500                 505                 510         


Cys Pro Leu Met Ser Asp Ser Asn Asn Phe Thr Thr Ile Ala Ile Pro 
        515                 520                 525             


Phe Gly Thr Ala Leu Val Asn Leu Glu Lys Ala Pro Leu Lys Val Leu 
    530                 535                 540                 


Glu Asn Trp Trp Ser Val Leu Glu Pro Pro Leu Phe Leu Lys Ile Val 
545                 550                 555                 560 


Glu Leu Phe Lys Glu Val Val Val His Leu Leu Lys Leu Tyr Lys Ile 
                565                 570                 575     


Gly Ile Pro Pro Ser Glu Arg Arg Ile Phe Asn Ser Phe Leu His Thr 
            580                 585                 590         


Ala Leu Lys Val Leu Glu Ile Leu His Arg Val Asn Glu Lys Met Gly 
        595                 600                 605             


Gln Ile Ile Gln Tyr Asp Lys Phe Tyr Ile His Glu Val Gln Glu Leu 
    610                 615                 620                 


Ile Asp Ile Arg Asn Asp Tyr Ile Asn Trp Val Gln Gln Gln Ala Tyr 
625                 630                 635                 640 


Gly Met Asp Val Asn His Gly Leu Thr Glu Leu Ala Asp Ile Pro Val 
                645                 650                 655     


Thr Ile Cys Thr Tyr Pro Phe Val Phe Asp Ala Gln Ala Lys Thr Thr 
            660                 665                 670         


Leu Leu Gln Thr Asp Ala Val Leu Gln Met Gln Met Ala Ile Asp Gln 
        675                 680                 685             


Ala His Arg Gln Asn Val Ser Ser Leu Phe Leu Pro Val Ile Glu Ser 
    690                 695                 700                 


Val Asn Pro Cys Leu Ile Leu Val Val Arg Arg Glu Asn Ile Val Gly 
705                 710                 715                 720 


Asp Ala Met Glu Val Leu Arg Lys Thr Lys Asn Ile Asp Tyr Lys Lys 
                725                 730                 735     


Pro Leu Lys Val Ile Phe Val Gly Glu Asp Ala Val Asp Ala Gly Gly 
            740                 745                 750         


Val Arg Lys Glu Phe Phe Leu Leu Ile Met Arg Glu Leu Leu Asp Pro 
        755                 760                 765             


Lys Tyr Gly Met Phe Arg Tyr Tyr Glu Asp Ser Arg Leu Ile Trp Phe 
    770                 775                 780                 


Ser Asp Lys Thr Phe Glu Asp Ser Asp Leu Phe His Leu Ile Gly Val 
785                 790                 795                 800 


Ile Cys Gly Leu Ala Ile Tyr Asn Cys Thr Ile Val Asp Leu His Phe 
                805                 810                 815     


Pro Leu Ala Leu Tyr Lys Lys Leu Leu Lys Lys Lys Pro Ser Leu Asp 
            820                 825                 830         


Asp Leu Lys Glu Leu Met Pro Asp Val Gly Arg Ser Met Gln Gln Leu 
        835                 840                 845             


Leu Asp Tyr Pro Glu Asp Asp Ile Glu Glu Thr Phe Cys Leu Asn Phe 
    850                 855                 860                 


Thr Ile Thr Val Glu Asn Phe Gly Ala Thr Glu Val Lys Glu Leu Val 
865                 870                 875                 880 


Leu Asn Gly Ala Asp Thr Ala Val Asn Lys Gln Asn Arg Gln Glu Phe 
                885                 890                 895     


Val Asp Ala Tyr Val Asp Tyr Ile Phe Asn Lys Ser Val Ala Ser Leu 
            900                 905                 910         


Phe Asp Ala Phe His Ala Gly Phe His Lys Val Cys Gly Gly Lys Val 
        915                 920                 925             


Leu Leu Leu Phe Gln Pro Asn Glu Leu Gln Ala Met Val Ile Gly Asn 
    930                 935                 940                 


Thr Asn Tyr Asp Trp Lys Glu Leu Glu Lys Asn Thr Glu Tyr Lys Gly 
945                 950                 955                 960 


Glu Tyr Trp Ala Glu His Pro Thr Ile Lys Ile Phe Trp Glu Val Phe 
                965                 970                 975     


His Glu Leu Pro Leu Glu Lys Lys Lys Gln Phe Leu Leu Phe Leu Thr 
            980                 985                 990         


Gly Ser Asp Arg Ile Pro Ile Leu  Gly Met Lys Ser Leu  Lys Leu Val 
        995                 1000                 1005             


Ile Gln  Ser Thr Gly Gly Gly  Glu Glu Tyr Leu Pro  Val Ser His 
    1010                 1015                 1020             


Thr Cys  Phe Asn Leu Leu Asp  Leu Pro Lys Tyr Thr  Glu Lys Glu 
    1025                 1030                 1035             


Thr Leu  Arg Ser Lys Leu Ile  Gln Ala Ile Asp His  Asn Glu Gly 
    1040                 1045                 1050             


Phe Ser  Leu Ile 
    1055         


<210>  163
<211>  2774
<212>  PRT
<213>  Homo sapiens

<400>  163

Met Asp Val Lys Asp Arg Arg His Arg Ser Leu Thr Arg Gly Arg Cys 
1               5                   10                  15      


Gly Lys Glu Cys Arg Tyr Thr Ser Ser Ser Leu Asp Ser Glu Asp Cys 
            20                  25                  30          


Arg Val Pro Thr Gln Lys Ser Tyr Ser Ser Ser Glu Thr Leu Lys Ala 
        35                  40                  45              


Tyr Asp His Asp Ser Arg Met His Tyr Gly Asn Arg Val Thr Asp Leu 
    50                  55                  60                  


Val His Arg Glu Ser Asp Glu Phe Ser Arg Gln Gly Thr Asn Phe Thr 
65                  70                  75                  80  


Leu Ala Glu Leu Gly Ile Cys Glu Pro Ser Pro His Arg Ser Gly Tyr 
                85                  90                  95      


Cys Ser Asp Met Gly Ile Leu His Gln Gly Tyr Ser Leu Ser Thr Gly 
            100                 105                 110         


Ser Asp Ala Asp Ser Asp Thr Glu Gly Gly Met Ser Pro Glu His Ala 
        115                 120                 125             


Ile Arg Leu Trp Gly Arg Gly Ile Lys Ser Arg Arg Ser Ser Gly Leu 
    130                 135                 140                 


Ser Ser Arg Glu Asn Ser Ala Leu Thr Leu Thr Asp Ser Asp Asn Glu 
145                 150                 155                 160 


Asn Lys Ser Asp Asp Asp Asn Gly Arg Pro Ile Pro Pro Thr Ser Ser 
                165                 170                 175     


Ser Ser Leu Leu Pro Ser Ala Gln Leu Pro Ser Ser His Asn Pro Pro 
            180                 185                 190         


Pro Val Ser Cys Gln Met Pro Leu Leu Asp Ser Asn Thr Ser His Gln 
        195                 200                 205             


Ile Met Asp Thr Asn Pro Asp Glu Glu Phe Ser Pro Asn Ser Tyr Leu 
    210                 215                 220                 


Leu Arg Ala Cys Ser Gly Pro Gln Gln Ala Ser Ser Ser Gly Pro Pro 
225                 230                 235                 240 


Asn His His Ser Gln Ser Thr Leu Arg Pro Pro Leu Pro Pro Pro His 
                245                 250                 255     


Asn His Thr Leu Ser His His His Ser Ser Ala Asn Ser Leu Asn Arg 
            260                 265                 270         


Asn Ser Leu Thr Asn Arg Arg Ser Gln Ile His Ala Pro Ala Pro Ala 
        275                 280                 285             


Pro Asn Asp Leu Ala Thr Thr Pro Glu Ser Val Gln Leu Gln Asp Ser 
    290                 295                 300                 


Trp Val Leu Asn Ser Asn Val Pro Leu Glu Thr Arg His Phe Leu Phe 
305                 310                 315                 320 


Lys Thr Ser Ser Gly Ser Thr Pro Leu Phe Ser Ser Ser Ser Pro Gly 
                325                 330                 335     


Tyr Pro Leu Thr Ser Gly Thr Val Tyr Thr Pro Pro Pro Arg Leu Leu 
            340                 345                 350         


Pro Arg Asn Thr Phe Ser Arg Lys Ala Phe Lys Leu Lys Lys Pro Ser 
        355                 360                 365             


Lys Tyr Cys Ser Trp Lys Cys Ala Ala Leu Ser Ala Ile Ala Ala Ala 
    370                 375                 380                 


Leu Leu Leu Ala Ile Leu Leu Ala Tyr Phe Ile Ala Met His Leu Leu 
385                 390                 395                 400 


Gly Leu Asn Trp Gln Leu Gln Pro Ala Asp Gly His Thr Phe Asn Asn 
                405                 410                 415     


Gly Val Arg Thr Gly Leu Pro Gly Asn Asp Asp Val Ala Thr Val Pro 
            420                 425                 430         


Ser Gly Gly Lys Val Pro Trp Ser Leu Lys Asn Ser Ser Ile Asp Ser 
        435                 440                 445             


Gly Glu Ala Glu Val Gly Arg Arg Val Thr Gln Glu Val Pro Pro Gly 
    450                 455                 460                 


Val Phe Trp Arg Ser Gln Ile His Ile Ser Gln Pro Gln Phe Leu Lys 
465                 470                 475                 480 


Phe Asn Ile Ser Leu Gly Lys Asp Ala Leu Phe Gly Val Tyr Ile Arg 
                485                 490                 495     


Arg Gly Leu Pro Pro Ser His Ala Gln Tyr Asp Phe Met Glu Arg Leu 
            500                 505                 510         


Asp Gly Lys Glu Lys Trp Ser Val Val Glu Ser Pro Arg Glu Arg Arg 
        515                 520                 525             


Ser Ile Gln Thr Leu Val Gln Asn Glu Ala Val Phe Val Gln Tyr Leu 
    530                 535                 540                 


Asp Val Gly Leu Trp His Leu Ala Phe Tyr Asn Asp Gly Lys Asp Lys 
545                 550                 555                 560 


Glu Met Val Ser Phe Asn Thr Val Val Leu Asp Ser Val Gln Asp Cys 
                565                 570                 575     


Pro Arg Asn Cys His Gly Asn Gly Glu Cys Val Ser Gly Leu Cys His 
            580                 585                 590         


Cys Phe Pro Gly Phe Leu Gly Ala Asp Cys Ala Lys Ala Ala Cys Pro 
        595                 600                 605             


Val Leu Cys Ser Gly Asn Gly Gln Tyr Ser Lys Gly Thr Cys Gln Cys 
    610                 615                 620                 


Tyr Ser Gly Trp Lys Gly Ala Glu Cys Asp Val Pro Met Asn Gln Cys 
625                 630                 635                 640 


Ile Asp Pro Ser Cys Gly Gly His Gly Ser Cys Ile Asp Gly Asn Cys 
                645                 650                 655     


Val Cys Ser Ala Gly Tyr Lys Gly Glu His Cys Glu Glu Val Asp Cys 
            660                 665                 670         


Leu Asp Pro Thr Cys Ser Ser His Gly Val Cys Val Asn Gly Glu Cys 
        675                 680                 685             


Leu Cys Ser Pro Gly Trp Gly Gly Leu Asn Cys Glu Leu Ala Arg Val 
    690                 695                 700                 


Gln Cys Pro Asp Gln Cys Ser Gly His Gly Thr Tyr Leu Pro Asp Thr 
705                 710                 715                 720 


Gly Leu Cys Ser Cys Asp Pro Asn Trp Met Gly Pro Asp Cys Ser Val 
                725                 730                 735     


Glu Val Cys Ser Val Asp Cys Gly Thr His Gly Val Cys Ile Gly Gly 
            740                 745                 750         


Ala Cys Arg Cys Glu Glu Gly Trp Thr Gly Ala Ala Cys Asp Gln Arg 
        755                 760                 765             


Val Cys His Pro Arg Cys Ile Glu His Gly Thr Cys Lys Asp Gly Lys 
    770                 775                 780                 


Cys Glu Cys Arg Glu Gly Trp Asn Gly Glu His Cys Thr Ile Gly Arg 
785                 790                 795                 800 


Gln Thr Ala Gly Thr Glu Thr Asp Gly Cys Pro Asp Leu Cys Asn Gly 
                805                 810                 815     


Asn Gly Arg Cys Thr Leu Gly Gln Asn Ser Trp Gln Cys Val Cys Gln 
            820                 825                 830         


Thr Gly Trp Arg Gly Pro Gly Cys Asn Val Ala Met Glu Thr Ser Cys 
        835                 840                 845             


Ala Asp Asn Lys Asp Asn Glu Gly Asp Gly Leu Val Asp Cys Leu Asp 
    850                 855                 860                 


Pro Asp Cys Cys Leu Gln Ser Ala Cys Gln Asn Ser Leu Leu Cys Arg 
865                 870                 875                 880 


Gly Ser Arg Asp Pro Leu Asp Ile Ile Gln Gln Gly Gln Thr Asp Trp 
                885                 890                 895     


Pro Ala Val Lys Ser Phe Tyr Asp Arg Ile Lys Leu Leu Ala Gly Lys 
            900                 905                 910         


Asp Ser Thr His Ile Ile Pro Gly Glu Asn Pro Phe Asn Ser Ser Leu 
        915                 920                 925             


Val Ser Leu Ile Arg Gly Gln Val Val Thr Thr Asp Gly Thr Pro Leu 
    930                 935                 940                 


Val Gly Val Asn Val Ser Phe Val Lys Tyr Pro Lys Tyr Gly Tyr Thr 
945                 950                 955                 960 


Ile Thr Arg Gln Asp Gly Thr Phe Asp Leu Ile Ala Asn Gly Gly Ala 
                965                 970                 975     


Ser Leu Thr Leu His Phe Glu Arg Ala Pro Phe Met Ser Gln Glu Arg 
            980                 985                 990         


Thr Val Trp Leu Pro Trp Asn Ser  Phe Tyr Ala Met Asp  Thr Leu Val 
        995                 1000                 1005             


Met Lys  Thr Glu Glu Asn Ser  Ile Pro Ser Cys Asp  Leu Ser Gly 
    1010                 1015                 1020             


Phe Val  Arg Pro Asp Pro Ile  Ile Ile Ser Ser Pro  Leu Ser Thr 
    1025                 1030                 1035             


Phe Phe  Ser Ala Ala Pro Gly  Gln Asn Pro Ile Val  Pro Glu Thr 
    1040                 1045                 1050             


Gln Val  Leu His Glu Glu Ile  Glu Leu Pro Gly Ser  Asn Val Lys 
    1055                 1060                 1065             


Leu Arg  Tyr Leu Ser Ser Arg  Thr Ala Gly Tyr Lys  Ser Leu Leu 
    1070                 1075                 1080             


Lys Ile  Thr Met Thr Gln Ser  Thr Val Pro Leu Asn  Leu Ile Arg 
    1085                 1090                 1095             


Val His  Leu Met Val Ala Val  Glu Gly His Leu Phe  Gln Lys Ser 
    1100                 1105                 1110             


Phe Gln  Ala Ser Pro Asn Leu  Ala Tyr Thr Phe Ile  Trp Asp Lys 
    1115                 1120                 1125             


Thr Asp  Ala Tyr Gly Gln Arg  Val Tyr Gly Leu Ser  Asp Ala Val 
    1130                 1135                 1140             


Val Ser  Val Gly Phe Glu Tyr  Glu Thr Cys Pro Ser  Leu Ile Leu 
    1145                 1150                 1155             


Trp Glu  Lys Arg Thr Ala Leu  Leu Gln Gly Phe Glu  Leu Asp Pro 
    1160                 1165                 1170             


Ser Asn  Leu Gly Gly Trp Ser  Leu Asp Lys His His  Ile Leu Asn 
    1175                 1180                 1185             


Val Lys  Ser Gly Ile Leu His  Lys Gly Thr Gly Glu  Asn Gln Phe 
    1190                 1195                 1200             


Leu Thr  Gln Gln Pro Ala Ile  Ile Thr Ser Ile Met  Gly Asn Gly 
    1205                 1210                 1215             


Arg Arg  Arg Ser Ile Ser Cys  Pro Ser Cys Asn Gly  Leu Ala Glu 
    1220                 1225                 1230             


Gly Asn  Lys Leu Leu Ala Pro  Val Ala Leu Ala Val  Gly Ile Asp 
    1235                 1240                 1245             


Gly Ser  Leu Tyr Val Gly Asp  Phe Asn Tyr Ile Arg  Arg Ile Phe 
    1250                 1255                 1260             


Pro Ser  Arg Asn Val Thr Ser  Ile Leu Glu Leu Arg  Asn Lys Glu 
    1265                 1270                 1275             


Phe Lys  His Ser Asn Asn Pro  Ala His Lys Tyr Tyr  Leu Ala Val 
    1280                 1285                 1290             


Asp Pro  Val Ser Gly Ser Leu  Tyr Val Ser Asp Thr  Asn Ser Arg 
    1295                 1300                 1305             


Arg Ile  Tyr Arg Val Lys Ser  Leu Ser Gly Thr Lys  Asp Leu Ala 
    1310                 1315                 1320             


Gly Asn  Ser Glu Val Val Ala  Gly Thr Gly Glu Gln  Cys Leu Pro 
    1325                 1330                 1335             


Phe Asp  Glu Ala Arg Cys Gly  Asp Gly Gly Lys Ala  Ile Asp Ala 
    1340                 1345                 1350             


Thr Leu  Met Ser Pro Arg Gly  Ile Ala Val Asp Lys  Asn Gly Leu 
    1355                 1360                 1365             


Met Tyr  Phe Val Asp Ala Thr  Met Ile Arg Lys Val  Asp Gln Asn 
    1370                 1375                 1380             


Gly Ile  Ile Ser Thr Leu Leu  Gly Ser Asn Asp Leu  Thr Ala Val 
    1385                 1390                 1395             


Arg Pro  Leu Ser Cys Asp Ser  Ser Met Asp Val Ala  Gln Val Arg 
    1400                 1405                 1410             


Leu Glu  Trp Pro Thr Asp Leu  Ala Val Asn Pro Met  Asp Asn Ser 
    1415                 1420                 1425             


Leu Tyr  Val Leu Glu Asn Asn  Val Ile Leu Arg Ile  Thr Glu Asn 
    1430                 1435                 1440             


His Gln  Val Ser Ile Ile Ala  Gly Arg Pro Met His  Cys Gln Val 
    1445                 1450                 1455             


Pro Gly  Ile Asp Tyr Ser Leu  Ser Lys Leu Ala Ile  His Ser Ala 
    1460                 1465                 1470             


Leu Glu  Ser Ala Ser Ala Ile  Ala Ile Ser His Thr  Gly Val Leu 
    1475                 1480                 1485             


Tyr Ile  Thr Glu Thr Asp Glu  Lys Lys Ile Asn Arg  Leu Arg Gln 
    1490                 1495                 1500             


Val Thr  Thr Asn Gly Glu Ile  Cys Leu Leu Ala Gly  Ala Ala Ser 
    1505                 1510                 1515             


Asp Cys  Asp Cys Lys Asn Asp  Val Asn Cys Asn Cys  Tyr Ser Gly 
    1520                 1525                 1530             


Asp Asp  Ala Tyr Ala Thr Asp  Ala Ile Leu Asn Ser  Pro Ser Ser 
    1535                 1540                 1545             


Leu Ala  Val Ala Pro Asp Gly  Thr Ile Tyr Ile Ala  Asp Leu Gly 
    1550                 1555                 1560             


Asn Ile  Arg Ile Arg Ala Val  Ser Lys Asn Lys Pro  Val Leu Asn 
    1565                 1570                 1575             


Ala Phe  Asn Gln Tyr Glu Ala  Ala Ser Pro Gly Glu  Gln Glu Leu 
    1580                 1585                 1590             


Tyr Val  Phe Asn Ala Asp Gly  Ile His Gln Tyr Thr  Val Ser Leu 
    1595                 1600                 1605             


Val Thr  Gly Glu Tyr Leu Tyr  Asn Phe Thr Tyr Ser  Thr Asp Asn 
    1610                 1615                 1620             


Asp Val  Thr Glu Leu Ile Asp  Asn Asn Gly Asn Ser  Leu Lys Ile 
    1625                 1630                 1635             


Arg Arg  Asp Ser Ser Gly Met  Pro Arg His Leu Leu  Met Pro Asp 
    1640                 1645                 1650             


Asn Gln  Ile Ile Thr Leu Thr  Val Gly Thr Asn Gly  Gly Leu Lys 
    1655                 1660                 1665             


Val Val  Ser Thr Gln Asn Leu  Glu Leu Gly Leu Met  Thr Tyr Asp 
    1670                 1675                 1680             


Gly Asn  Thr Gly Leu Leu Ala  Thr Lys Ser Asp Glu  Thr Gly Trp 
    1685                 1690                 1695             


Thr Thr  Phe Tyr Asp Tyr Asp  His Glu Gly Arg Leu  Thr Asn Val 
    1700                 1705                 1710             


Thr Arg  Pro Thr Gly Val Val  Thr Ser Leu His Arg  Glu Met Glu 
    1715                 1720                 1725             


Lys Ser  Ile Thr Ile Asp Ile  Glu Asn Ser Asn Arg  Asp Asp Asp 
    1730                 1735                 1740             


Val Thr  Val Ile Thr Asn Leu  Ser Ser Val Glu Ala  Ser Tyr Thr 
    1745                 1750                 1755             


Val Val  Gln Asp Gln Val Arg  Asn Ser Tyr Gln Leu  Cys Asn Asn 
    1760                 1765                 1770             


Gly Thr  Leu Arg Val Met Tyr  Ala Asn Gly Met Gly  Ile Ser Phe 
    1775                 1780                 1785             


His Ser  Glu Pro His Val Leu  Ala Gly Thr Ile Thr  Pro Thr Ile 
    1790                 1795                 1800             


Gly Arg  Cys Asn Ile Ser Leu  Pro Met Glu Asn Gly  Leu Asn Ser 
    1805                 1810                 1815             


Ile Glu  Trp Arg Leu Arg Lys  Glu Gln Ile Lys Gly  Lys Val Thr 
    1820                 1825                 1830             


Ile Phe  Gly Arg Lys Leu Arg  Val His Gly Arg Asn  Leu Leu Ser 
    1835                 1840                 1845             


Ile Asp  Tyr Asp Arg Asn Ile  Arg Thr Glu Lys Ile  Tyr Asp Asp 
    1850                 1855                 1860             


His Arg  Lys Phe Thr Leu Arg  Ile Ile Tyr Asp Gln  Val Gly Arg 
    1865                 1870                 1875             


Pro Phe  Leu Trp Leu Pro Ser  Ser Gly Leu Ala Ala  Val Asn Val 
    1880                 1885                 1890             


Ser Tyr  Phe Phe Asn Gly Arg  Leu Ala Gly Leu Gln  Arg Gly Ala 
    1895                 1900                 1905             


Met Ser  Glu Arg Thr Asp Ile  Asp Lys Gln Gly Arg  Ile Val Ser 
    1910                 1915                 1920             


Arg Met  Phe Ala Asp Gly Lys  Val Trp Ser Tyr Ser  Tyr Leu Asp 
    1925                 1930                 1935             


Lys Ser  Met Val Leu Leu Leu  Gln Ser Gln Arg Gln  Tyr Ile Phe 
    1940                 1945                 1950             


Glu Tyr  Asp Ser Ser Asp Arg  Leu Leu Ala Val Thr  Met Pro Ser 
    1955                 1960                 1965             


Val Ala  Arg His Ser Met Ser  Thr His Thr Ser Ile  Gly Tyr Ile 
    1970                 1975                 1980             


Arg Asn  Ile Tyr Asn Pro Pro  Glu Ser Asn Ala Ser  Val Ile Phe 
    1985                 1990                 1995             


Asp Tyr  Ser Asp Asp Gly Arg  Ile Leu Lys Thr Ser  Phe Leu Gly 
    2000                 2005                 2010             


Thr Gly  Arg Gln Val Phe Tyr  Lys Tyr Gly Lys Leu  Ser Lys Leu 
    2015                 2020                 2025             


Ser Glu  Ile Val Tyr Asp Ser  Thr Ala Val Thr Phe  Gly Tyr Asp 
    2030                 2035                 2040             


Glu Thr  Thr Gly Val Leu Lys  Met Val Asn Leu Gln  Ser Gly Gly 
    2045                 2050                 2055             


Phe Ser  Cys Thr Ile Arg Tyr  Arg Lys Ile Gly Pro  Leu Val Asp 
    2060                 2065                 2070             


Lys Gln  Ile Tyr Arg Phe Ser  Glu Glu Gly Met Val  Asn Ala Arg 
    2075                 2080                 2085             


Phe Asp  Tyr Thr Tyr His Asp  Asn Ser Phe Arg Ile  Ala Ser Ile 
    2090                 2095                 2100             


Lys Pro  Val Ile Ser Glu Thr  Pro Leu Pro Val Asp  Leu Tyr Arg 
    2105                 2110                 2115             


Tyr Asp  Glu Ile Ser Gly Lys  Val Glu His Phe Gly  Lys Phe Gly 
    2120                 2125                 2130             


Val Ile  Tyr Tyr Asp Ile Asn  Gln Ile Ile Thr Thr  Ala Val Met 
    2135                 2140                 2145             


Thr Leu  Ser Lys His Phe Asp  Thr His Gly Arg Ile  Lys Glu Val 
    2150                 2155                 2160             


Gln Tyr  Glu Met Phe Arg Ser  Leu Met Tyr Trp Met  Thr Val Gln 
    2165                 2170                 2175             


Tyr Asp  Ser Met Gly Arg Val  Ile Lys Arg Glu Leu  Lys Leu Gly 
    2180                 2185                 2190             


Pro Tyr  Ala Asn Thr Thr Lys  Tyr Thr Tyr Asp Tyr  Asp Gly Asp 
    2195                 2200                 2205             


Gly Gln  Leu Gln Ser Val Ala  Val Asn Asp Arg Pro  Thr Trp Arg 
    2210                 2215                 2220             


Tyr Ser  Tyr Asp Leu Asn Gly  Asn Leu His Leu Leu  Asn Pro Gly 
    2225                 2230                 2235             


Asn Ser  Val Arg Leu Met Pro  Leu Arg Tyr Asp Leu  Arg Asp Arg 
    2240                 2245                 2250             


Ile Thr  Arg Leu Gly Asp Val  Gln Tyr Lys Ile Asp  Asp Asp Gly 
    2255                 2260                 2265             


Tyr Leu  Cys Gln Arg Gly Ser  Asp Ile Phe Glu Tyr  Asn Ser Lys 
    2270                 2275                 2280             


Gly Leu  Leu Thr Arg Ala Tyr  Asn Lys Ala Ser Gly  Trp Ser Val 
    2285                 2290                 2295             


Gln Tyr  Arg Tyr Asp Gly Val  Gly Arg Arg Ala Ser  Tyr Lys Thr 
    2300                 2305                 2310             


Asn Leu  Gly His His Leu Gln  Tyr Phe Tyr Ser Asp  Leu His Asn 
    2315                 2320                 2325             


Pro Thr  Arg Ile Thr His Val  Tyr Asn His Ser Asn  Ser Glu Ile 
    2330                 2335                 2340             


Thr Ser  Leu Tyr Tyr Asp Leu  Gln Gly His Leu Phe  Ala Met Glu 
    2345                 2350                 2355             


Ser Ser  Ser Gly Glu Glu Tyr  Tyr Val Ala Ser Asp  Asn Thr Gly 
    2360                 2365                 2370             


Thr Pro  Leu Ala Val Phe Ser  Ile Asn Gly Pro Met  Ile Lys Gln 
    2375                 2380                 2385             


Leu Gln  Tyr Thr Ala Tyr Gly  Glu Ile Tyr Tyr Asp  Ser Asn Pro 
    2390                 2395                 2400             


Asp Phe  Gln Met Val Ile Gly  Phe His Gly Gly Leu  Tyr Asp Pro 
    2405                 2410                 2415             


Leu Thr  Lys Leu Val His Phe  Thr Gln Arg Asp Tyr  Asp Val Leu 
    2420                 2425                 2430             


Ala Gly  Arg Trp Thr Ser Pro  Asp Tyr Thr Met Trp  Lys Asn Val 
    2435                 2440                 2445             


Gly Lys  Glu Pro Ala Pro Phe  Asn Leu Tyr Met Phe  Lys Ser Asn 
    2450                 2455                 2460             


Asn Pro  Leu Ser Ser Glu Leu  Asp Leu Lys Asn Tyr  Val Thr Asp 
    2465                 2470                 2475             


Val Lys  Ser Trp Leu Val Met  Phe Gly Phe Gln Leu  Ser Asn Ile 
    2480                 2485                 2490             


Ile Pro  Gly Phe Pro Arg Ala  Lys Met Tyr Phe Val  Pro Pro Pro 
    2495                 2500                 2505             


Tyr Glu  Leu Ser Glu Ser Gln  Ala Ser Glu Asn Gly  Gln Leu Ile 
    2510                 2515                 2520             


Thr Gly  Val Gln Gln Thr Thr  Glu Arg His Asn Gln  Ala Phe Met 
    2525                 2530                 2535             


Ala Leu  Glu Gly Gln Val Ile  Thr Lys Lys Leu His  Ala Ser Ile 
    2540                 2545                 2550             


Arg Glu  Lys Ala Gly His Trp  Phe Ala Thr Thr Thr  Pro Ile Ile 
    2555                 2560                 2565             


Gly Lys  Gly Ile Met Phe Ala  Ile Lys Glu Gly Arg  Val Thr Thr 
    2570                 2575                 2580             


Gly Val  Ser Ser Ile Ala Ser  Glu Asp Ser Arg Lys  Val Ala Ser 
    2585                 2590                 2595             


Val Leu  Asn Asn Ala Tyr Tyr  Leu Asp Lys Met His  Tyr Ser Ile 
    2600                 2605                 2610             


Glu Gly  Lys Asp Thr His Tyr  Phe Val Lys Ile Gly  Ser Ala Asp 
    2615                 2620                 2625             


Gly Asp  Leu Val Thr Leu Gly  Thr Thr Ile Gly Arg  Lys Val Leu 
    2630                 2635                 2640             


Glu Ser  Gly Val Asn Val Thr  Val Ser Gln Pro Thr  Leu Leu Val 
    2645                 2650                 2655             


Asn Gly  Arg Thr Arg Arg Phe  Thr Asn Ile Glu Phe  Gln Tyr Ser 
    2660                 2665                 2670             


Thr Leu  Leu Leu Ser Ile Arg  Tyr Gly Leu Thr Pro  Asp Thr Leu 
    2675                 2680                 2685             


Asp Glu  Glu Lys Ala Arg Val  Leu Asp Gln Ala Arg  Gln Arg Ala 
    2690                 2695                 2700             


Leu Gly  Thr Ala Trp Ala Lys  Glu Gln Gln Lys Ala  Arg Asp Gly 
    2705                 2710                 2715             


Arg Glu  Gly Ser Arg Leu Trp  Thr Glu Gly Glu Lys  Gln Gln Leu 
    2720                 2725                 2730             


Leu Ser  Thr Gly Arg Val Gln  Gly Tyr Glu Gly Tyr  Tyr Val Leu 
    2735                 2740                 2745             


Pro Val  Glu Gln Tyr Pro Glu  Leu Ala Asp Ser Ser  Ser Asn Ile 
    2750                 2755                 2760             


Gln Phe  Leu Arg Gln Asn Glu  Met Gly Lys Arg 
    2765                 2770                 


<210>  164
<211>  341
<212>  PRT
<213>  Homo sapiens

<400>  164

Met Thr Met Glu Ser Gly Ala Glu Asn Gln Gln Ser Gly Asp Ala Ala 
1               5                   10                  15      


Val Thr Glu Ala Glu Asn Gln Gln Met Thr Val Gln Ala Gln Pro Gln 
            20                  25                  30          


Ile Ala Thr Leu Ala Gln Val Ser Met Pro Ala Ala His Ala Thr Ser 
        35                  40                  45              


Ser Ala Pro Thr Val Thr Leu Val Gln Leu Pro Asn Gly Gln Thr Val 
    50                  55                  60                  


Gln Val His Gly Val Ile Gln Ala Ala Gln Pro Ser Val Ile Gln Ser 
65                  70                  75                  80  


Pro Gln Val Gln Thr Val Gln Ser Ser Cys Lys Asp Leu Lys Arg Leu 
                85                  90                  95      


Phe Ser Gly Thr Gln Ile Ser Thr Ile Ala Glu Ser Glu Asp Ser Gln 
            100                 105                 110         


Glu Ser Val Asp Ser Val Thr Asp Ser Gln Lys Arg Arg Glu Ile Leu 
        115                 120                 125             


Ser Arg Arg Pro Ser Tyr Arg Lys Ile Leu Asn Asp Leu Ser Ser Asp 
    130                 135                 140                 


Ala Pro Gly Val Pro Arg Ile Glu Glu Glu Lys Ser Glu Glu Glu Thr 
145                 150                 155                 160 


Ser Ala Pro Ala Ile Thr Thr Val Thr Val Pro Thr Pro Ile Tyr Gln 
                165                 170                 175     


Thr Ser Ser Gly Gln Tyr Ile Ala Ile Thr Gln Gly Gly Ala Ile Gln 
            180                 185                 190         


Leu Ala Asn Asn Gly Thr Asp Gly Val Gln Gly Leu Gln Thr Leu Thr 
        195                 200                 205             


Met Thr Asn Ala Ala Ala Thr Gln Pro Gly Thr Thr Ile Leu Gln Tyr 
    210                 215                 220                 


Ala Gln Thr Thr Asp Gly Gln Gln Ile Leu Val Pro Ser Asn Gln Val 
225                 230                 235                 240 


Val Val Gln Ala Ala Ser Gly Asp Val Gln Thr Tyr Gln Ile Arg Thr 
                245                 250                 255     


Ala Pro Thr Ser Thr Ile Ala Pro Gly Val Val Met Ala Ser Ser Pro 
            260                 265                 270         


Ala Leu Pro Thr Gln Pro Ala Glu Glu Ala Ala Arg Lys Arg Glu Val 
        275                 280                 285             


Arg Leu Met Lys Asn Arg Glu Ala Ala Arg Glu Cys Arg Arg Lys Lys 
    290                 295                 300                 


Lys Glu Tyr Val Lys Cys Leu Glu Asn Arg Val Ala Val Leu Glu Asn 
305                 310                 315                 320 


Gln Asn Lys Thr Leu Ile Glu Glu Leu Lys Ala Leu Lys Asp Leu Tyr 
                325                 330                 335     


Cys His Lys Ser Asp 
            340     


<210>  165
<211>  1057
<212>  PRT
<213>  Homo sapiens

<400>  165

Met Leu Cys Trp Gly Asn Ala Ser Phe Gly Gln Leu Gly Leu Gly Gly 
1               5                   10                  15      


Ile Asp Glu Glu Ile Val Leu Glu Pro Arg Lys Ser Asp Phe Phe Ile 
            20                  25                  30          


Asn Lys Arg Val Arg Asp Val Gly Cys Gly Leu Arg His Thr Val Phe 
        35                  40                  45              


Val Leu Asp Asp Gly Thr Val Tyr Thr Cys Gly Cys Asn Asp Leu Gly 
    50                  55                  60                  


Gln Leu Gly His Glu Lys Ser Arg Lys Lys Pro Glu Gln Val Val Ala 
65                  70                  75                  80  


Leu Asp Ala Gln Asn Ile Val Ala Val Ser Cys Gly Glu Ala His Thr 
                85                  90                  95      


Leu Ala Leu Asn Asp Lys Gly Gln Val Tyr Ala Trp Gly Leu Asp Ser 
            100                 105                 110         


Asp Gly Gln Leu Gly Leu Val Gly Ser Glu Glu Cys Ile Arg Val Pro 
        115                 120                 125             


Arg Asn Ile Lys Ser Leu Ser Asp Ile Gln Ile Val Gln Val Ala Cys 
    130                 135                 140                 


Gly Tyr Tyr His Ser Leu Ala Leu Ser Lys Ala Ser Glu Val Phe Cys 
145                 150                 155                 160 


Trp Gly Gln Asn Lys Tyr Gly Gln Leu Gly Leu Gly Thr Asp Cys Lys 
                165                 170                 175     


Lys Gln Thr Ser Pro Gln Leu Leu Lys Ser Leu Leu Gly Ile Pro Phe 
            180                 185                 190         


Met Gln Val Ala Ala Gly Gly Ala His Ser Phe Val Leu Thr Leu Ser 
        195                 200                 205             


Gly Ala Ile Phe Gly Trp Gly Arg Asn Lys Phe Gly Gln Leu Gly Leu 
    210                 215                 220                 


Asn Asp Glu Asn Asp Arg Tyr Val Pro Asn Leu Leu Lys Ser Leu Arg 
225                 230                 235                 240 


Ser Gln Lys Ile Val Tyr Ile Cys Cys Gly Glu Asp His Thr Ala Ala 
                245                 250                 255     


Leu Thr Lys Glu Gly Gly Val Phe Thr Phe Gly Ala Gly Gly Tyr Gly 
            260                 265                 270         


Gln Leu Gly His Asn Ser Thr Ser His Glu Ile Asn Pro Arg Lys Val 
        275                 280                 285             


Phe Glu Leu Met Gly Ser Ile Val Thr Glu Ile Ala Cys Gly Arg Gln 
    290                 295                 300                 


His Thr Ser Ala Phe Val Pro Ser Ser Gly Arg Ile Tyr Ser Phe Gly 
305                 310                 315                 320 


Leu Gly Gly Asn Gly Gln Leu Gly Thr Gly Ser Thr Ser Asn Arg Lys 
                325                 330                 335     


Ser Pro Phe Thr Val Lys Gly Asn Trp Tyr Pro Tyr Asn Gly Gln Cys 
            340                 345                 350         


Leu Pro Asp Ile Asp Ser Glu Glu Tyr Phe Cys Val Lys Arg Ile Phe 
        355                 360                 365             


Ser Gly Gly Asp Gln Ser Phe Ser His Tyr Ser Ser Pro Gln Asn Cys 
    370                 375                 380                 


Gly Pro Pro Asp Asp Phe Arg Cys Pro Asn Pro Thr Lys Gln Ile Trp 
385                 390                 395                 400 


Thr Val Asn Glu Ala Leu Ile Gln Lys Trp Leu Ser Tyr Pro Ser Gly 
                405                 410                 415     


Arg Phe Pro Val Glu Ile Ala Asn Glu Ile Asp Gly Thr Phe Ser Ser 
            420                 425                 430         


Ser Gly Cys Leu Asn Gly Ser Phe Leu Ala Val Ser Asn Asp Asp His 
        435                 440                 445             


Tyr Arg Thr Gly Thr Arg Phe Ser Gly Val Asp Met Asn Ala Ala Arg 
    450                 455                 460                 


Leu Leu Phe His Lys Leu Ile Gln Pro Asp His Pro Gln Ile Ser Gln 
465                 470                 475                 480 


Gln Val Ala Ala Ser Leu Glu Lys Asn Leu Ile Pro Lys Leu Thr Ser 
                485                 490                 495     


Ser Leu Pro Asp Val Glu Ala Leu Arg Phe Tyr Leu Thr Leu Pro Glu 
            500                 505                 510         


Cys Pro Leu Met Ser Asp Ser Asn Asn Phe Thr Thr Ile Ala Ile Pro 
        515                 520                 525             


Phe Gly Thr Ala Leu Val Asn Leu Glu Lys Ala Pro Leu Lys Val Leu 
    530                 535                 540                 


Glu Asn Trp Trp Ser Val Leu Glu Pro Pro Leu Phe Leu Lys Ile Val 
545                 550                 555                 560 


Glu Leu Phe Lys Glu Val Val Val His Leu Leu Lys Leu Tyr Lys Ile 
                565                 570                 575     


Gly Ile Pro Pro Ser Glu Arg Arg Ile Phe Asn Ser Phe Leu His Thr 
            580                 585                 590         


Ala Leu Lys Val Leu Glu Ile Leu His Arg Val Asn Glu Lys Met Gly 
        595                 600                 605             


Gln Ile Ile Gln Tyr Asp Lys Phe Tyr Ile His Glu Val Gln Glu Leu 
    610                 615                 620                 


Ile Asp Ile Arg Asn Asp Tyr Ile Asn Trp Val Gln Gln Gln Ala Tyr 
625                 630                 635                 640 


Gly Met Asp Val Asn His Gly Leu Thr Glu Leu Ala Asp Ile Pro Val 
                645                 650                 655     


Thr Ile Cys Thr Tyr Pro Phe Val Phe Asp Ala Gln Ala Lys Thr Thr 
            660                 665                 670         


Leu Leu Gln Thr Asp Ala Val Leu Gln Met Gln Met Ala Ile Asp Gln 
        675                 680                 685             


Ala His Arg Gln Asn Val Ser Ser Leu Phe Leu Pro Val Ile Glu Ser 
    690                 695                 700                 


Val Asn Pro Cys Leu Ile Leu Val Val Arg Arg Glu Asn Ile Val Gly 
705                 710                 715                 720 


Asp Ala Met Glu Val Leu Arg Lys Thr Lys Asn Ile Asp Tyr Lys Lys 
                725                 730                 735     


Pro Leu Lys Val Ile Phe Val Gly Glu Asp Ala Val Asp Ala Gly Gly 
            740                 745                 750         


Val Arg Lys Glu Phe Phe Leu Leu Ile Met Arg Glu Leu Leu Asp Pro 
        755                 760                 765             


Lys Tyr Gly Met Phe Arg Tyr Tyr Glu Asp Ser Arg Leu Ile Trp Phe 
    770                 775                 780                 


Ser Asp Lys Thr Phe Glu Asp Ser Asp Leu Phe His Leu Ile Gly Val 
785                 790                 795                 800 


Ile Cys Gly Leu Ala Ile Tyr Asn Cys Thr Ile Val Asp Leu His Phe 
                805                 810                 815     


Pro Leu Ala Leu Tyr Lys Lys Leu Leu Lys Lys Lys Pro Ser Leu Asp 
            820                 825                 830         


Asp Leu Lys Glu Leu Met Pro Asp Val Gly Arg Ser Met Gln Gln Leu 
        835                 840                 845             


Leu Asp Tyr Pro Glu Asp Asp Ile Glu Glu Thr Phe Cys Leu Asn Phe 
    850                 855                 860                 


Thr Ile Thr Val Glu Asn Phe Gly Ala Thr Glu Val Lys Glu Leu Val 
865                 870                 875                 880 


Leu Asn Gly Ala Asp Thr Ala Val Asn Lys Gln Asn Arg Gln Glu Phe 
                885                 890                 895     


Val Asp Ala Tyr Val Asp Tyr Ile Phe Asn Lys Ser Val Ala Ser Leu 
            900                 905                 910         


Phe Asp Ala Phe His Ala Gly Phe His Lys Val Cys Gly Gly Lys Val 
        915                 920                 925             


Leu Leu Leu Phe Gln Pro Asn Glu Leu Gln Ala Met Val Ile Gly Asn 
    930                 935                 940                 


Thr Asn Tyr Asp Trp Lys Glu Leu Glu Lys Asn Thr Glu Tyr Lys Gly 
945                 950                 955                 960 


Glu Tyr Trp Ala Glu His Pro Thr Ile Lys Ile Phe Trp Glu Val Phe 
                965                 970                 975     


His Glu Leu Pro Leu Glu Lys Lys Lys Gln Phe Leu Leu Phe Leu Thr 
            980                 985                 990         


Gly Ser Asp Arg Ile Pro Ile Leu  Gly Met Lys Ser Leu  Lys Leu Val 
        995                 1000                 1005             


Ile Gln  Ser Thr Gly Gly Gly  Glu Glu Tyr Leu Pro  Val Ser His 
    1010                 1015                 1020             


Thr Cys  Phe Asn Leu Leu Asp  Leu Pro Lys Tyr Thr  Glu Lys Glu 
    1025                 1030                 1035             


Thr Leu  Arg Ser Lys Leu Ile  Gln Ala Ile Asp His  Asn Glu Gly 
    1040                 1045                 1050             


Phe Ser  Leu Ile 
    1055         


<210>  166
<211>  8797
<212>  PRT
<213>  Homo sapiens

<400>  166

Met Ala Thr Ser Arg Gly Ala Ser Arg Cys Pro Arg Asp Ile Ala Asn 
1               5                   10                  15      


Val Met Gln Arg Leu Gln Asp Glu Gln Glu Ile Val Gln Lys Arg Thr 
            20                  25                  30          


Phe Thr Lys Trp Ile Asn Ser His Leu Ala Lys Arg Lys Pro Pro Met 
        35                  40                  45              


Val Val Asp Asp Leu Phe Glu Asp Met Lys Asp Gly Val Lys Leu Leu 
    50                  55                  60                  


Ala Leu Leu Glu Val Leu Ser Gly Gln Lys Leu Pro Cys Glu Gln Gly 
65                  70                  75                  80  


Arg Arg Met Lys Arg Ile His Ala Val Ala Asn Ile Gly Thr Ala Leu 
                85                  90                  95      


Lys Phe Leu Glu Gly Arg Lys Ile Lys Leu Val Asn Ile Asn Ser Thr 
            100                 105                 110         


Asp Ile Ala Asp Gly Arg Pro Ser Ile Val Leu Gly Leu Met Trp Thr 
        115                 120                 125             


Ile Ile Leu Tyr Phe Gln Ile Glu Glu Leu Thr Ser Asn Leu Pro Gln 
    130                 135                 140                 


Leu Gln Ser Leu Ser Ser Ser Ala Ser Ser Val Asp Ser Ile Val Ser 
145                 150                 155                 160 


Ser Glu Thr Pro Ser Pro Pro Ser Lys Arg Lys Val Thr Thr Lys Ile 
                165                 170                 175     


Gln Gly Asn Ala Lys Lys Ala Leu Leu Lys Trp Val Gln Tyr Thr Ala 
            180                 185                 190         


Gly Lys Gln Thr Gly Ile Glu Val Lys Asp Phe Gly Lys Ser Trp Arg 
        195                 200                 205             


Ser Gly Val Ala Phe His Ser Val Ile His Ala Ile Arg Pro Glu Leu 
    210                 215                 220                 


Val Asp Leu Glu Thr Val Lys Gly Arg Ser Asn Arg Glu Asn Leu Glu 
225                 230                 235                 240 


Asp Ala Phe Thr Ile Ala Glu Thr Glu Leu Gly Ile Pro Arg Leu Leu 
                245                 250                 255     


Asp Pro Glu Asp Val Asp Val Asp Lys Pro Asp Glu Lys Ser Ile Met 
            260                 265                 270         


Thr Tyr Val Ala Gln Phe Leu Lys His Tyr Pro Asp Ile His Asn Ala 
        275                 280                 285             


Ser Thr Asp Gly Gln Glu Asp Asp Glu Ile Leu Pro Gly Phe Pro Ser 
    290                 295                 300                 


Phe Ala Asn Ser Val Gln Asn Phe Lys Arg Glu Asp Arg Val Ile Phe 
305                 310                 315                 320 


Lys Glu Met Lys Val Trp Ile Glu Gln Phe Glu Arg Asp Leu Thr Arg 
                325                 330                 335     


Ala Gln Met Val Glu Ser Asn Leu Gln Asp Lys Tyr Gln Ser Phe Lys 
            340                 345                 350         


His Phe Arg Val Gln Tyr Glu Met Lys Arg Lys Gln Ile Glu His Leu 
        355                 360                 365             


Ile Gln Pro Leu His Arg Asp Gly Lys Leu Ser Leu Asp Gln Ala Leu 
    370                 375                 380                 


Val Lys Gln Ser Trp Asp Arg Val Thr Ser Arg Leu Phe Asp Trp His 
385                 390                 395                 400 


Ile Gln Leu Asp Lys Ser Leu Pro Ala Pro Leu Gly Thr Ile Gly Ala 
                405                 410                 415     


Trp Leu Tyr Arg Ala Glu Val Ala Leu Arg Glu Glu Ile Thr Val Gln 
            420                 425                 430         


Gln Val His Glu Glu Thr Ala Asn Thr Ile Gln Arg Lys Leu Glu Gln 
        435                 440                 445             


His Lys Asp Leu Leu Gln Asn Thr Asp Ala His Lys Arg Ala Phe His 
    450                 455                 460                 


Glu Ile Tyr Arg Thr Arg Ser Val Asn Gly Ile Pro Val Pro Pro Asp 
465                 470                 475                 480 


Gln Leu Glu Asp Met Ala Glu Arg Phe His Phe Val Ser Ser Thr Ser 
                485                 490                 495     


Glu Leu His Leu Met Lys Met Glu Phe Leu Glu Leu Lys Tyr Arg Leu 
            500                 505                 510         


Leu Ser Leu Leu Val Leu Ala Glu Ser Lys Leu Lys Ser Trp Ile Ile 
        515                 520                 525             


Lys Tyr Gly Arg Arg Glu Ser Val Glu Gln Leu Leu Gln Asn Tyr Val 
    530                 535                 540                 


Ser Phe Ile Glu Asn Ser Lys Phe Phe Glu Gln Tyr Glu Val Thr Tyr 
545                 550                 555                 560 


Gln Ile Leu Lys Gln Thr Ala Glu Met Tyr Val Lys Ala Asp Gly Ser 
                565                 570                 575     


Val Glu Glu Ala Glu Asn Val Met Lys Phe Met Asn Glu Thr Thr Ala 
            580                 585                 590         


Gln Trp Arg Asn Leu Ser Val Glu Val Arg Ser Val Arg Ser Met Leu 
        595                 600                 605             


Glu Glu Val Ile Ser Asn Trp Asp Arg Tyr Gly Asn Thr Val Ala Ser 
    610                 615                 620                 


Leu Gln Ala Trp Leu Glu Asp Ala Glu Lys Met Leu Asn Gln Ser Glu 
625                 630                 635                 640 


Asn Ala Lys Lys Asp Phe Phe Arg Asn Leu Pro His Trp Ile Gln Gln 
                645                 650                 655     


His Thr Ala Met Asn Asp Ala Gly Asn Phe Leu Ile Glu Thr Cys Asp 
            660                 665                 670         


Glu Met Val Ser Arg Asp Leu Lys Gln Gln Leu Leu Leu Leu Asn Gly 
        675                 680                 685             


Arg Trp Arg Glu Leu Phe Met Glu Val Lys Gln Tyr Ala Gln Ala Asp 
    690                 695                 700                 


Glu Met Asp Arg Met Lys Lys Glu Tyr Thr Asp Cys Val Val Thr Leu 
705                 710                 715                 720 


Ser Ala Phe Ala Thr Glu Ala His Lys Lys Leu Ser Glu Pro Leu Glu 
                725                 730                 735     


Val Ser Phe Met Asn Val Lys Leu Leu Ile Gln Asp Leu Glu Asp Ile 
            740                 745                 750         


Glu Gln Arg Val Pro Val Met Asp Ala Gln Tyr Lys Ile Ile Thr Lys 
        755                 760                 765             


Thr Ala His Leu Ile Thr Lys Glu Ser Pro Gln Glu Glu Gly Lys Glu 
    770                 775                 780                 


Met Phe Ala Thr Met Ser Lys Leu Lys Glu Gln Leu Thr Lys Val Lys 
785                 790                 795                 800 


Glu Cys Tyr Ser Pro Leu Leu Tyr Glu Ser Gln Gln Leu Leu Ile Pro 
                805                 810                 815     


Leu Glu Glu Leu Glu Lys Gln Met Thr Ser Phe Tyr Asp Ser Leu Gly 
            820                 825                 830         


Lys Ile Asn Glu Ile Ile Thr Val Leu Glu Arg Glu Ala Gln Ser Ser 
        835                 840                 845             


Ala Leu Phe Lys Gln Lys His Gln Glu Leu Leu Ala Cys Gln Glu Asn 
    850                 855                 860                 


Cys Lys Lys Thr Leu Thr Leu Ile Glu Lys Gly Ser Gln Ser Val Gln 
865                 870                 875                 880 


Lys Phe Val Thr Leu Ser Asn Val Leu Lys His Phe Asp Gln Thr Arg 
                885                 890                 895     


Leu Gln Arg Gln Ile Ala Asp Ile His Val Ala Phe Gln Ser Met Val 
            900                 905                 910         


Lys Lys Thr Gly Asp Trp Lys Lys His Val Glu Thr Asn Ser Arg Leu 
        915                 920                 925             


Met Lys Lys Phe Glu Glu Ser Arg Ala Glu Leu Glu Lys Val Leu Arg 
    930                 935                 940                 


Ile Ala Gln Glu Gly Leu Glu Glu Lys Gly Asp Pro Glu Glu Leu Leu 
945                 950                 955                 960 


Arg Arg His Thr Glu Phe Phe Ser Gln Leu Asp Gln Arg Val Leu Asn 
                965                 970                 975     


Ala Phe Leu Lys Ala Cys Asp Glu Leu Thr Asp Ile Leu Pro Glu Gln 
            980                 985                 990         


Glu Gln Gln Gly Leu Gln Glu Ala  Val Arg Lys Leu His  Lys Gln Trp 
        995                 1000                 1005             


Lys Asp  Leu Gln Gly Glu Ala  Pro Tyr His Leu Leu  His Leu Lys 
    1010                 1015                 1020             


Ile Asp  Val Glu Lys Asn Arg  Phe Leu Ala Ser Val  Glu Glu Cys 
    1025                 1030                 1035             


Arg Thr  Glu Leu Asp Arg Glu  Thr Lys Leu Met Pro  Gln Glu Gly 
    1040                 1045                 1050             


Ser Glu  Lys Ile Ile Lys Glu  His Arg Val Phe Phe  Ser Asp Lys 
    1055                 1060                 1065             


Gly Pro  His His Leu Cys Glu  Lys Arg Leu Gln Leu  Ile Glu Glu 
    1070                 1075                 1080             


Leu Cys  Val Lys Leu Pro Val  Arg Asp Pro Val Arg  Asp Thr Pro 
    1085                 1090                 1095             


Gly Thr  Cys His Val Thr Leu  Lys Glu Leu Arg Ala  Ala Ile Asp 
    1100                 1105                 1110             


Ser Thr  Tyr Arg Lys Leu Met  Glu Asp Pro Asp Lys  Trp Lys Asp 
    1115                 1120                 1125             


Tyr Thr  Ser Arg Phe Ser Glu  Phe Ser Ser Trp Ile  Ser Thr Asn 
    1130                 1135                 1140             


Glu Thr  Gln Leu Lys Gly Ile  Lys Gly Glu Ala Ile  Asp Thr Ala 
    1145                 1150                 1155             


Asn His  Gly Glu Val Lys Arg  Ala Val Glu Glu Ile  Arg Asn Gly 
    1160                 1165                 1170             


Val Thr  Lys Arg Gly Glu Thr  Leu Ser Trp Leu Lys  Ser Arg Leu 
    1175                 1180                 1185             


Lys Val  Leu Thr Glu Val Ser  Ser Glu Asn Glu Ala  Gln Lys Gln 
    1190                 1195                 1200             


Gly Asp  Glu Leu Ala Lys Leu  Ser Ser Ser Phe Lys  Ala Leu Val 
    1205                 1210                 1215             


Thr Leu  Leu Ser Glu Val Glu  Lys Met Leu Ser Asn  Phe Gly Asp 
    1220                 1225                 1230             


Cys Val  Gln Tyr Lys Glu Ile  Val Lys Asn Ser Leu  Glu Glu Leu 
    1235                 1240                 1245             


Ile Ser  Gly Ser Lys Glu Val  Gln Glu Gln Ala Glu  Lys Ile Leu 
    1250                 1255                 1260             


Asp Thr  Glu Asn Leu Phe Glu  Ala Gln Gln Leu Leu  Leu His His 
    1265                 1270                 1275             


Gln Gln  Lys Thr Lys Arg Ile  Ser Ala Lys Lys Arg  Asp Val Gln 
    1280                 1285                 1290             


Gln Gln  Ile Ala Gln Ala Gln  Gln Gly Glu Gly Gly  Leu Pro Asp 
    1295                 1300                 1305             


Arg Gly  His Glu Glu Leu Arg  Lys Leu Glu Ser Thr  Leu Asp Gly 
    1310                 1315                 1320             


Leu Glu  Arg Ser Arg Glu Arg  Gln Glu Arg Arg Ile  Gln Val Thr 
    1325                 1330                 1335             


Leu Arg  Lys Trp Glu Arg Phe  Glu Thr Asn Lys Glu  Thr Val Val 
    1340                 1345                 1350             


Arg Tyr  Leu Phe Gln Thr Gly  Ser Ser His Glu Arg  Phe Leu Ser 
    1355                 1360                 1365             


Phe Ser  Ser Leu Glu Ser Leu  Ser Ser Glu Leu Glu  Gln Thr Lys 
    1370                 1375                 1380             


Glu Phe  Ser Lys Arg Thr Glu  Ser Ile Ala Val Gln  Ala Glu Asn 
    1385                 1390                 1395             


Leu Val  Lys Glu Ala Ser Glu  Ile Pro Leu Gly Pro  Gln Asn Lys 
    1400                 1405                 1410             


Gln Leu  Leu Gln Gln Gln Ala  Lys Ser Ile Lys Glu  Gln Val Lys 
    1415                 1420                 1425             


Lys Leu  Glu Asp Thr Leu Glu  Glu Asp Ile Lys Thr  Met Glu Met 
    1430                 1435                 1440             


Val Lys  Thr Lys Trp Asp His  Phe Gly Ser Asn Phe  Glu Thr Leu 
    1445                 1450                 1455             


Ser Val  Trp Ile Thr Glu Lys  Glu Lys Glu Leu Asn  Ala Leu Glu 
    1460                 1465                 1470             


Thr Ser  Ser Ser Ala Met Asp  Met Gln Ile Ser Gln  Ile Lys Val 
    1475                 1480                 1485             


Thr Ile  Gln Glu Ile Glu Ser  Lys Leu Ser Ser Ile  Val Gly Leu 
    1490                 1495                 1500             


Glu Glu  Glu Ala Gln Ser Phe  Ala Gln Phe Val Thr  Thr Gly Glu 
    1505                 1510                 1515             


Ser Ala  Arg Ile Lys Ala Lys  Leu Thr Gln Ile Arg  Arg Tyr Gly 
    1520                 1525                 1530             


Glu Glu  Leu Arg Glu His Ala  Gln Cys Leu Glu Gly  Thr Ile Leu 
    1535                 1540                 1545             


Gly His  Leu Ser Gln Gln Gln  Lys Phe Glu Glu Asn  Leu Arg Lys 
    1550                 1555                 1560             


Ile Gln  Gln Ser Val Ser Glu  Phe Glu Asp Lys Leu  Ala Val Pro 
    1565                 1570                 1575             


Ile Lys  Ile Cys Ser Ser Ala  Thr Glu Thr Tyr Lys  Val Leu Gln 
    1580                 1585                 1590             


Glu His  Met Asp Leu Cys Gln  Ala Leu Glu Ser Leu  Ser Ser Ala 
    1595                 1600                 1605             


Ile Thr  Ala Phe Ser Ala Ser  Ala Arg Lys Val Val  Asn Arg Asp 
    1610                 1615                 1620             


Ser Cys  Val Gln Glu Ala Ala  Ala Leu Gln Gln Gln  Tyr Glu Asp 
    1625                 1630                 1635             


Ile Leu  Arg Arg Ala Lys Glu  Arg Gln Thr Ala Leu  Glu Asn Leu 
    1640                 1645                 1650             


Leu Ala  His Trp Gln Arg Leu  Glu Lys Glu Leu Ser  Ser Phe Leu 
    1655                 1660                 1665             


Thr Trp  Leu Glu Arg Gly Glu  Ala Lys Ala Ser Ser  Pro Glu Met 
    1670                 1675                 1680             


Asp Ile  Ser Ala Asp Arg Val  Lys Val Glu Gly Glu  Leu Gln Leu 
    1685                 1690                 1695             


Ile Gln  Ala Leu Gln Asn Glu  Val Val Ser Gln Ala  Ser Phe Tyr 
    1700                 1705                 1710             


Ser Lys  Leu Leu Gln Leu Lys  Glu Ser Leu Phe Ser  Val Ala Ser 
    1715                 1720                 1725             


Lys Asp  Asp Val Lys Met Met  Lys Leu His Leu Glu  Gln Leu Asp 
    1730                 1735                 1740             


Glu Arg  Trp Arg Asp Leu Pro  Gln Ile Ile Asn Lys  Arg Ile Asn 
    1745                 1750                 1755             


Phe Leu  Gln Ser Val Val Ala  Glu His Gln Gln Phe  Asp Glu Leu 
    1760                 1765                 1770             


Leu Leu  Ser Phe Ser Val Trp  Ile Lys Leu Phe Leu  Ser Glu Leu 
    1775                 1780                 1785             


Gln Thr  Thr Ser Glu Ile Ser  Ile Met Asp His Gln  Val Ala Leu 
    1790                 1795                 1800             


Thr Arg  His Lys Asp His Ala  Ala Glu Val Glu Ser  Lys Lys Gly 
    1805                 1810                 1815             


Glu Leu  Gln Ser Leu Gln Gly  His Leu Ala Lys Leu  Gly Ser Leu 
    1820                 1825                 1830             


Gly Arg  Ala Glu Asp Leu His  Leu Leu Gln Gly Lys  Ala Glu Asp 
    1835                 1840                 1845             


Cys Phe  Gln Leu Phe Glu Glu  Ala Ser Gln Val Val  Glu Arg Arg 
    1850                 1855                 1860             


Gln Leu  Ala Leu Ser His Leu  Ala Glu Phe Leu Gln  Ser His Ala 
    1865                 1870                 1875             


Ser Leu  Ser Gly Ile Leu Arg  Gln Leu Arg Gln Thr  Val Glu Ala 
    1880                 1885                 1890             


Thr Asn  Ser Met Asn Lys Asn  Glu Ser Asp Leu Ile  Glu Lys Asp 
    1895                 1900                 1905             


Leu Asn  Asp Ala Leu Gln Asn  Ala Lys Ala Leu Glu  Ser Ala Ala 
    1910                 1915                 1920             


Val Ser  Leu Asp Gly Ile Leu  Ser Lys Ala Gln Tyr  His Leu Lys 
    1925                 1930                 1935             


Ile Gly  Ser Ser Glu Gln Arg  Thr Ser Cys Arg Ala  Thr Ala Asp 
    1940                 1945                 1950             


Gln Leu  Cys Gly Glu Val Glu  Arg Ile Gln Asn Leu  Leu Gly Thr 
    1955                 1960                 1965             


Lys Gln  Ser Glu Ala Asp Ala  Leu Ala Val Leu Lys  Lys Ala Phe 
    1970                 1975                 1980             


Gln Asp  Gln Lys Glu Glu Leu  Leu Lys Ser Ile Glu  Asp Ile Glu 
    1985                 1990                 1995             


Glu Arg  Thr Asp Lys Glu Arg  Leu Lys Glu Pro Thr  Arg Gln Ala 
    2000                 2005                 2010             


Leu Gln  Gln Arg Leu Arg Val  Phe Asn Gln Leu Glu  Asp Glu Leu 
    2015                 2020                 2025             


Asn Ser  His Glu His Glu Leu  Cys Trp Leu Lys Asp  Lys Ala Lys 
    2030                 2035                 2040             


Gln Ile  Ala Gln Lys Asp Val  Ala Phe Ala Pro Glu  Val Asp Arg 
    2045                 2050                 2055             


Glu Ile  Asn Arg Leu Glu Val  Thr Trp Asp Asp Thr  Lys Arg Leu 
    2060                 2065                 2070             


Ile His  Glu Asn Gln Gly Gln  Cys Cys Gly Leu Ile  Asp Leu Met 
    2075                 2080                 2085             


Arg Glu  Tyr Gln Asn Leu Lys  Ser Ala Val Ser Lys  Val Leu Glu 
    2090                 2095                 2100             


Asn Ala  Ser Ser Val Ile Val  Thr Arg Thr Thr Ile  Lys Asp Gln 
    2105                 2110                 2115             


Glu Asp  Leu Lys Trp Ala Phe  Ser Lys His Glu Thr  Ala Lys Asn 
    2120                 2125                 2130             


Lys Met  Asn Tyr Lys Gln Lys  Asp Leu Asp Asn Phe  Thr Ser Lys 
    2135                 2140                 2145             


Gly Lys  His Leu Leu Ser Glu  Leu Lys Lys Ile His  Ser Ser Asp 
    2150                 2155                 2160             


Phe Ser  Leu Val Lys Thr Asp  Met Glu Ser Thr Val  Asp Lys Trp 
    2165                 2170                 2175             


Leu Asp  Val Ser Glu Lys Leu  Glu Glu Asn Met Asp  Arg Leu Arg 
    2180                 2185                 2190             


Val Ser  Leu Ser Ile Trp Asp  Asp Val Leu Ser Thr  Arg Asp Glu 
    2195                 2200                 2205             


Ile Glu  Gly Trp Ser Asn Asn  Cys Val Pro Gln Met  Ala Glu Asn 
    2210                 2215                 2220             


Ile Ser  Asn Leu Asp Asn His  Leu Arg Ala Glu Glu  Leu Leu Lys 
    2225                 2230                 2235             


Glu Phe  Glu Ser Glu Val Lys  Asn Lys Ala Leu Arg  Leu Glu Glu 
    2240                 2245                 2250             


Leu His  Ser Lys Val Asn Asp  Leu Lys Glu Leu Thr  Lys Asn Leu 
    2255                 2260                 2265             


Glu Thr  Pro Pro Asp Leu Gln  Phe Ile Glu Ala Asp  Leu Met Gln 
    2270                 2275                 2280             


Lys Leu  Glu His Ala Lys Glu  Ile Thr Glu Val Ala  Lys Gly Thr 
    2285                 2290                 2295             


Leu Lys  Asp Phe Thr Ala Gln  Ser Thr Gln Val Glu  Lys Phe Ile 
    2300                 2305                 2310             


Asn Asp  Ile Thr Thr Trp Phe  Thr Lys Val Glu Glu  Ser Leu Met 
    2315                 2320                 2325             


Asn Cys  Ala Gln Asn Glu Thr  Cys Glu Ala Leu Lys  Lys Val Lys 
    2330                 2335                 2340             


Asp Ile  Gln Lys Glu Leu Gln  Ser Gln Gln Ser Asn  Ile Ser Ser 
    2345                 2350                 2355             


Thr Gln  Glu Asn Leu Asn Ser  Leu Cys Arg Lys Tyr  His Ser Ala 
    2360                 2365                 2370             


Glu Leu  Glu Ser Leu Gly Arg  Ala Met Thr Gly Leu  Ile Lys Lys 
    2375                 2380                 2385             


His Glu  Ala Val Ser Gln Leu  Cys Ser Lys Thr Gln  Ala Ser Leu 
    2390                 2395                 2400             


Gln Glu  Ser Leu Glu Lys His  Phe Ser Glu Ser Met  Gln Glu Phe 
    2405                 2410                 2415             


Gln Glu  Trp Phe Leu Gly Ala  Lys Ala Ala Ala Lys  Glu Ser Ser 
    2420                 2425                 2430             


Asp Arg  Thr Gly Asp Ser Lys  Val Leu Glu Ala Lys  Leu His Asp 
    2435                 2440                 2445             


Leu Gln  Asn Ile Leu Asp Ser  Val Ser Asp Gly Gln  Ser Lys Leu 
    2450                 2455                 2460             


Asp Ala  Val Thr Gln Glu Gly  Gln Thr Leu Tyr Ala  His Leu Ser 
    2465                 2470                 2475             


Lys Gln  Ile Val Ser Ser Ile  Gln Glu Gln Ile Thr  Lys Ala Asn 
    2480                 2485                 2490             


Glu Glu  Phe Gln Ala Phe Leu  Lys Gln Cys Leu Lys  Asp Lys Gln 
    2495                 2500                 2505             


Ala Leu  Gln Asp Cys Ala Ser  Glu Leu Gly Ser Phe  Glu Asp Gln 
    2510                 2515                 2520             


His Arg  Lys Leu Asn Leu Trp  Ile His Glu Met Glu  Glu Arg Phe 
    2525                 2530                 2535             


Asn Thr  Glu Asn Leu Gly Glu  Ser Lys Gln His Ile  Pro Glu Lys 
    2540                 2545                 2550             


Lys Asn  Glu Val His Lys Val  Glu Met Phe Leu Gly  Glu Leu Leu 
    2555                 2560                 2565             


Ala Ala  Arg Glu Ser Leu Asp  Lys Leu Ser Gln Arg  Gly Gln Leu 
    2570                 2575                 2580             


Leu Ser  Glu Glu Gly His Gly  Ala Gly Gln Glu Gly  Arg Leu Cys 
    2585                 2590                 2595             


Ser Gln  Leu Leu Thr Ser His  Gln Asn Leu Leu Arg  Met Thr Lys 
    2600                 2605                 2610             


Glu Lys  Leu Arg Ser Cys Gln  Val Ala Leu Gln Glu  His Glu Ala 
    2615                 2620                 2625             


Leu Glu  Glu Ala Leu Gln Ser  Met Trp Phe Trp Val  Lys Ala Ile 
    2630                 2635                 2640             


Gln Asp  Arg Leu Ala Cys Ala  Glu Ser Thr Leu Gly  Ser Lys Asp 
    2645                 2650                 2655             


Thr Leu  Glu Lys Arg Leu Ser  Gln Ile Gln Asp Ile  Leu Leu Met 
    2660                 2665                 2670             


Lys Gly  Glu Gly Glu Val Lys  Leu Asn Met Ala Ile  Gly Lys Gly 
    2675                 2680                 2685             


Glu Gln  Ala Leu Arg Ser Ser  Asn Lys Glu Gly Gln  Arg Val Ile 
    2690                 2695                 2700             


Gln Thr  Gln Leu Glu Thr Leu  Lys Glu Val Trp Ala  Asp Ile Met 
    2705                 2710                 2715             


Ser Ser  Ser Val His Ala Gln  Ser Thr Leu Glu Ser  Val Ile Ser 
    2720                 2725                 2730             


Gln Trp  Asn Asp Tyr Val Glu  Arg Lys Asn Gln Leu  Glu Gln Trp 
    2735                 2740                 2745             


Met Glu  Ser Val Asp Gln Lys  Ile Glu His Pro Leu  Gln Pro Gln 
    2750                 2755                 2760             


Pro Gly  Leu Lys Glu Lys Phe  Val Leu Leu Asp His  Leu Gln Ser 
    2765                 2770                 2775             


Ile Leu  Ser Glu Ala Glu Asp  His Thr Arg Ala Leu  His Arg Leu 
    2780                 2785                 2790             


Ile Ala  Lys Ser Arg Glu Leu  Tyr Glu Lys Thr Glu  Asp Glu Ser 
    2795                 2800                 2805             


Phe Lys  Asp Thr Ala Gln Glu  Glu Leu Lys Thr Gln  Phe Asn Asp 
    2810                 2815                 2820             


Ile Met  Thr Val Ala Lys Glu  Lys Met Arg Lys Val  Glu Glu Ile 
    2825                 2830                 2835             


Val Lys  Asp His Leu Met Tyr  Leu Asp Ala Val His  Glu Phe Thr 
    2840                 2845                 2850             


Asp Trp  Leu His Ser Ala Lys  Glu Glu Leu His Arg  Trp Ser Asp 
    2855                 2860                 2865             


Met Ser  Gly Asp Ser Ser Ala  Thr Gln Lys Lys Leu  Ser Lys Ile 
    2870                 2875                 2880             


Lys Glu  Leu Ile Asp Ser Arg  Glu Ile Gly Ala Ser  Arg Leu Ser 
    2885                 2890                 2895             


Arg Val  Glu Ser Leu Ala Pro  Glu Val Lys Gln Asn  Thr Thr Ala 
    2900                 2905                 2910             


Ser Gly  Cys Glu Leu Met His  Thr Glu Met Gln Ala  Leu Arg Ala 
    2915                 2920                 2925             


Asp Trp  Lys Gln Trp Glu Asp  Ser Val Phe Gln Thr  Gln Ser Cys 
    2930                 2935                 2940             


Leu Glu  Asn Leu Val Ser Gln  Met Ala Leu Ser Glu  Gln Glu Phe 
    2945                 2950                 2955             


Ser Gly  Gln Val Ala Gln Leu  Glu Gln Ala Leu Glu  Gln Phe Ser 
    2960                 2965                 2970             


Ala Leu  Leu Lys Thr Trp Ala  Gln Gln Leu Thr Leu  Leu Glu Gly 
    2975                 2980                 2985             


Lys Asn  Thr Asp Glu Glu Ile  Val Glu Cys Trp His  Lys Gly Gln 
    2990                 2995                 3000             


Glu Ile  Leu Asp Ala Leu Gln  Lys Ala Glu Pro Arg  Thr Glu Asp 
    3005                 3010                 3015             


Leu Lys  Ser Gln Leu Asn Glu  Leu Cys Arg Phe Ser  Arg Asp Leu 
    3020                 3025                 3030             


Ser Thr  Tyr Ser Gly Lys Val  Ser Gly Leu Ile Lys  Glu Tyr Asn 
    3035                 3040                 3045             


Cys Leu  Cys Leu Gln Ala Ser  Lys Gly Cys Gln Asn  Lys Glu Gln 
    3050                 3055                 3060             


Ile Leu  Gln Gln Arg Phe Arg  Lys Ala Phe Arg Asp  Phe Gln Gln 
    3065                 3070                 3075             


Trp Leu  Val Asn Ala Lys Ile  Thr Thr Ala Lys Cys  Phe Asp Ile 
    3080                 3085                 3090             


Pro Gln  Asn Ile Ser Glu Val  Ser Thr Ser Leu Gln  Lys Ile Gln 
    3095                 3100                 3105             


Glu Phe  Leu Ser Glu Ser Glu  Asn Gly Gln His Lys  Leu Asn Met 
    3110                 3115                 3120             


Met Leu  Ser Lys Gly Glu Leu  Leu Ser Thr Leu Leu  Thr Lys Glu 
    3125                 3130                 3135             


Lys Ala  Lys Gly Ile Gln Ala  Lys Val Thr Ala Ala  Lys Glu Asp 
    3140                 3145                 3150             


Trp Lys  Asn Phe His Ser Asn  Leu His Gln Lys Glu  Ser Ala Leu 
    3155                 3160                 3165             


Glu Asn  Leu Lys Ile Gln Met  Lys Asp Phe Glu Val  Ser Ala Glu 
    3170                 3175                 3180             


Pro Ile  Gln Asp Trp Leu Ser  Lys Thr Glu Lys Met  Val His Glu 
    3185                 3190                 3195             


Ser Ser  Asn Arg Leu Tyr Asp  Leu Pro Ala Lys Arg  Arg Glu Gln 
    3200                 3205                 3210             


Gln Lys  Leu Gln Ser Val Leu  Glu Glu Ile His Cys  Tyr Glu Pro 
    3215                 3220                 3225             


Gln Leu  Asn Arg Leu Lys Glu  Lys Ala Gln Gln Leu  Trp Glu Gly 
    3230                 3235                 3240             


Gln Ala  Ala Ser Lys Ser Phe  Arg His Arg Val Ser  Gln Leu Ser 
    3245                 3250                 3255             


Ser Gln  Tyr Leu Ala Leu Ser  Asn Leu Thr Lys Glu  Lys Val Ser 
    3260                 3265                 3270             


Arg Leu  Asp Arg Ile Val Ala  Glu His Asn Gln Phe  Ser Leu Gly 
    3275                 3280                 3285             


Ile Lys  Glu Leu Gln Asp Trp  Met Thr Asp Ala Ile  His Met Leu 
    3290                 3295                 3300             


Asp Ser  Tyr Cys His Pro Thr  Ser Asp Lys Ser Val  Leu Asp Ser 
    3305                 3310                 3315             


Arg Thr  Leu Lys Leu Glu Ala  Leu Leu Ser Val Lys  Gln Glu Lys 
    3320                 3325                 3330             


Glu Ile  Gln Met Lys Met Ile  Val Thr Arg Gly Glu  Ser Val Leu 
    3335                 3340                 3345             


Gln Asn  Thr Ser Pro Glu Gly  Ile Pro Thr Ile Gln  Gln Gln Leu 
    3350                 3355                 3360             


Gln Ser  Val Lys Asp Met Trp  Ala Ser Leu Leu Ser  Ala Gly Ile 
    3365                 3370                 3375             


Arg Cys  Lys Ser Gln Leu Glu  Gly Ala Leu Ser Lys  Trp Thr Ser 
    3380                 3385                 3390             


Tyr Gln  Asp Gly Val Arg Gln  Phe Ser Gly Trp Met  Asp Ser Met 
    3395                 3400                 3405             


Glu Ala  Asn Leu Asn Glu Ser  Glu Arg Gln His Ala  Glu Leu Arg 
    3410                 3415                 3420             


Asp Lys  Thr Thr Met Leu Gly  Lys Ala Lys Leu Leu  Asn Glu Glu 
    3425                 3430                 3435             


Val Leu  Ser Tyr Ser Ser Leu  Leu Glu Thr Ile Glu  Val Lys Gly 
    3440                 3445                 3450             


Ala Gly  Met Thr Glu His Tyr  Val Thr Gln Leu Glu  Leu Gln Asp 
    3455                 3460                 3465             


Leu Gln  Glu Arg Tyr Arg Ala  Ile Gln Glu Arg Ala  Lys Glu Ala 
    3470                 3475                 3480             


Val Thr  Lys Ser Glu Lys Leu  Val Arg Leu His Gln  Glu Tyr Gln 
    3485                 3490                 3495             


Arg Asp  Leu Lys Ala Phe Glu  Val Trp Leu Gly Gln  Glu Gln Glu 
    3500                 3505                 3510             


Lys Leu  Asp Gln Tyr Ser Val  Leu Glu Gly Asp Ala  His Thr His 
    3515                 3520                 3525             


Glu Thr  Thr Leu Arg Asp Leu  Gln Glu Leu Gln Val  His Cys Ala 
    3530                 3535                 3540             


Glu Gly  Gln Ala Leu Leu Asn  Ser Val Leu His Thr  Arg Glu Asp 
    3545                 3550                 3555             


Val Ile  Pro Ser Gly Ile Pro  Gln Ala Glu Asp Arg  Ala Leu Glu 
    3560                 3565                 3570             


Ser Leu  Arg Gln Asp Trp Gln  Ala Tyr Gln His Arg  Leu Ser Glu 
    3575                 3580                 3585             


Thr Arg  Thr Gln Phe Asn Asn  Val Val Asn Lys Leu  Arg Leu Met 
    3590                 3595                 3600             


Glu Gln  Lys Phe Gln Gln Val  Asp Glu Trp Leu Lys  Thr Ala Glu 
    3605                 3610                 3615             


Glu Lys  Val Ser Pro Arg Thr  Arg Arg Gln Ser Asn  Arg Ala Thr 
    3620                 3625                 3630             


Lys Glu  Ile Gln Leu His Gln  Met Lys Lys Trp His  Glu Glu Val 
    3635                 3640                 3645             


Thr Ala  Tyr Arg Asp Glu Val  Glu Glu Val Gly Ala  Arg Ala Gln 
    3650                 3655                 3660             


Glu Ile  Leu Asp Glu Ser His  Val Asn Ser Arg Met  Gly Cys Gln 
    3665                 3670                 3675             


Ala Thr  Gln Leu Thr Ser Arg  Tyr Gln Ala Leu Leu  Leu Gln Val 
    3680                 3685                 3690             


Leu Glu  Gln Ile Lys Phe Leu  Glu Glu Glu Ile Gln  Ser Leu Glu 
    3695                 3700                 3705             


Glu Ser  Glu Ser Ser Leu Ser  Ser Tyr Ser Asp Trp  Tyr Gly Ser 
    3710                 3715                 3720             


Thr His  Lys Asn Phe Lys Asn  Val Ala Thr Lys Ile  Asp Lys Val 
    3725                 3730                 3735             


Asp Thr  Val Met Met Gly Lys  Lys Leu Lys Thr Leu  Glu Val Leu 
    3740                 3745                 3750             


Leu Lys  Asp Met Glu Lys Gly  His Ser Leu Leu Lys  Ser Ala Arg 
    3755                 3760                 3765             


Glu Lys  Gly Glu Arg Ala Val  Lys Tyr Leu Glu Glu  Gly Glu Ala 
    3770                 3775                 3780             


Glu Arg  Leu Arg Lys Glu Ile  His Asp His Met Glu  Gln Leu Lys 
    3785                 3790                 3795             


Glu Leu  Thr Ser Thr Val Arg  Lys Glu His Met Thr  Leu Glu Lys 
    3800                 3805                 3810             


Gly Leu  His Leu Ala Lys Glu  Phe Ser Asp Lys Cys  Lys Ala Leu 
    3815                 3820                 3825             


Thr Gln  Trp Ile Ala Glu Tyr  Gln Glu Ile Leu His  Val Pro Glu 
    3830                 3835                 3840             


Glu Pro  Lys Met Glu Leu Tyr  Glu Lys Lys Ala Gln  Leu Ser Lys 
    3845                 3850                 3855             


Tyr Lys  Ser Leu Gln Gln Thr  Val Leu Ser His Glu  Pro Ser Val 
    3860                 3865                 3870             


Lys Ser  Val Arg Glu Lys Gly  Glu Ala Leu Leu Glu  Leu Val Gln 
    3875                 3880                 3885             


Asp Val  Thr Leu Lys Asp Lys  Ile Asp Gln Leu Gln  Ser Asp Tyr 
    3890                 3895                 3900             


Gln Asp  Leu Cys Ser Ile Gly  Lys Glu His Val Phe  Ser Leu Glu 
    3905                 3910                 3915             


Ala Lys  Val Lys Asp His Glu  Asp Tyr Asn Ser Glu  Leu Gln Glu 
    3920                 3925                 3930             


Val Glu  Lys Trp Leu Leu Gln  Met Ser Gly Arg Leu  Val Ala Pro 
    3935                 3940                 3945             


Asp Leu  Leu Glu Thr Ser Ser  Leu Glu Thr Ile Thr  Gln Gln Leu 
    3950                 3955                 3960             


Ala His  His Lys Ala Met Met  Glu Glu Ile Ala Gly  Phe Glu Asp 
    3965                 3970                 3975             


Arg Leu  Asn Asn Leu Gln Met  Lys Gly Asp Thr Leu  Ile Gly Gln 
    3980                 3985                 3990             


Cys Ala  Asp His Leu Gln Ala  Lys Leu Lys Gln Asn  Val His Ala 
    3995                 4000                 4005             


His Leu  Gln Gly Thr Lys Asp  Ser Tyr Ser Ala Ile  Cys Ser Thr 
    4010                 4015                 4020             


Ala Gln  Arg Met Tyr Gln Ser  Leu Glu His Glu Leu  Gln Lys His 
    4025                 4030                 4035             


Val Ser  Arg Gln Asp Thr Leu  Gln Gln Cys Gln Ala  Trp Leu Ser 
    4040                 4045                 4050             


Ala Val  Gln Pro Asp Leu Glu  Pro Ser Pro Gln Pro  Pro Leu Ser 
    4055                 4060                 4065             


Arg Ala  Glu Ala Ile Lys Gln  Val Lys His Phe Arg  Ala Leu Gln 
    4070                 4075                 4080             


Glu Gln  Ala Arg Thr Tyr Leu  Asp Leu Leu Cys Ser  Met Cys Asp 
    4085                 4090                 4095             


Leu Ser  Asn Ala Ser Val Lys  Thr Thr Ala Lys Asp  Ile Gln Gln 
    4100                 4105                 4110             


Thr Glu  Gln Thr Ile Glu Gln  Lys Leu Val Gln Ala  Gln Asn Leu 
    4115                 4120                 4125             


Thr Gln  Gly Trp Glu Glu Ile  Lys His Leu Lys Ser  Glu Leu Trp 
    4130                 4135                 4140             


Ile Tyr  Leu Gln Asp Ala Asp  Gln Gln Leu Gln Asn  Met Lys Arg 
    4145                 4150                 4155             


Arg His  Ser Glu Leu Glu Leu  Asn Ile Ala Gln Asn  Met Val Ser 
    4160                 4165                 4170             


Gln Val  Lys Asp Phe Val Lys  Lys Leu Gln Ser Lys  Gln Ala Ser 
    4175                 4180                 4185             


Val Asn  Thr Ile Ile Glu Lys  Val Asn Lys Leu Thr  Lys Lys Glu 
    4190                 4195                 4200             


Glu Ser  Pro Glu His Lys Glu  Ile Asn His Leu Asn  Asp Gln Trp 
    4205                 4210                 4215             


Leu Asp  Leu Cys Arg Gln Ser  Asn Asn Leu Cys Leu  Gln Arg Glu 
    4220                 4225                 4230             


Glu Asp  Leu Gln Arg Thr Arg  Asp Tyr His Asp Cys  Met Asn Val 
    4235                 4240                 4245             


Val Glu  Val Phe Leu Glu Lys  Phe Thr Thr Glu Trp  Asp Asn Leu 
    4250                 4255                 4260             


Ala Arg  Ser Asp Ala Glu Ser  Thr Ala Val His Leu  Glu Ala Leu 
    4265                 4270                 4275             


Lys Lys  Leu Ala Leu Ala Leu  Gln Glu Arg Lys Tyr  Ala Ile Glu 
    4280                 4285                 4290             


Asp Leu  Lys Asp Gln Lys Gln  Lys Met Ile Glu His  Leu Asn Leu 
    4295                 4300                 4305             


Asp Asp  Lys Glu Leu Val Lys  Glu Gln Thr Ser His  Leu Glu Gln 
    4310                 4315                 4320             


Arg Trp  Phe Gln Leu Glu Asp  Leu Ile Lys Arg Lys  Ile Gln Val 
    4325                 4330                 4335             


Ser Val  Thr Asn Leu Glu Glu  Leu Asn Val Val Gln  Ser Arg Phe 
    4340                 4345                 4350             


Gln Glu  Leu Met Glu Trp Ala  Glu Glu Gln Gln Pro  Asn Ile Ala 
    4355                 4360                 4365             


Glu Ala  Leu Lys Gln Ser Pro  Pro Pro Asp Met Ala  Gln Asn Leu 
    4370                 4375                 4380             


Leu Met  Asp His Leu Ala Ile  Cys Ser Glu Leu Glu  Ala Lys Gln 
    4385                 4390                 4395             


Met Leu  Leu Lys Ser Leu Ile  Lys Asp Ala Asp Arg  Val Met Ala 
    4400                 4405                 4410             


Asp Leu  Gly Leu Asn Glu Arg  Gln Val Ile Gln Lys  Ala Leu Ser 
    4415                 4420                 4425             


Asp Ala  Gln Ser His Val Asn  Cys Leu Ser Asp Leu  Val Gly Gln 
    4430                 4435                 4440             


Arg Arg  Lys Tyr Leu Asn Lys  Ala Leu Ser Glu Lys  Thr Gln Phe 
    4445                 4450                 4455             


Leu Met  Ala Val Phe Gln Ala  Thr Ser Gln Ile Gln  Gln His Glu 
    4460                 4465                 4470             


Arg Lys  Ile Met Phe Arg Glu  His Ile Cys Leu Leu  Pro Asp Asp 
    4475                 4480                 4485             


Val Ser  Lys Gln Val Lys Thr  Cys Lys Ser Ala Gln  Ala Ser Leu 
    4490                 4495                 4500             


Lys Thr  Tyr Gln Asn Glu Val  Thr Gly Leu Trp Ala  Gln Gly Arg 
    4505                 4510                 4515             


Glu Leu  Met Lys Glu Val Thr  Glu Gln Glu Lys Ser  Glu Val Leu 
    4520                 4525                 4530             


Gly Lys  Leu Gln Glu Leu Gln  Ser Val Tyr Asp Ser  Val Leu Gln 
    4535                 4540                 4545             


Lys Cys  Ser His Arg Leu Gln  Glu Leu Glu Lys Asn  Leu Val Ser 
    4550                 4555                 4560             


Arg Lys  His Phe Lys Glu Asp  Phe Asp Lys Ala Cys  His Trp Leu 
    4565                 4570                 4575             


Lys Gln  Ala Asp Ile Val Thr  Phe Pro Glu Ile Asn  Leu Met Asn 
    4580                 4585                 4590             


Glu Ser  Ser Glu Leu His Thr  Gln Leu Ala Lys Tyr  Gln Asn Ile 
    4595                 4600                 4605             


Leu Glu  Gln Ser Pro Glu Tyr  Glu Asn Leu Leu Leu  Thr Leu Gln 
    4610                 4615                 4620             


Arg Thr  Gly Gln Thr Ile Leu  Pro Ser Leu Asn Glu  Val Asp His 
    4625                 4630                 4635             


Ser Tyr  Leu Ser Glu Lys Leu  Asn Ala Leu Pro Arg  Gln Phe Asn 
    4640                 4645                 4650             


Val Ile  Val Ala Leu Ala Lys  Asp Lys Phe Tyr Lys  Val Gln Glu 
    4655                 4660                 4665             


Ala Ile  Leu Ala Arg Lys Glu  Tyr Ala Ser Leu Ile  Glu Leu Thr 
    4670                 4675                 4680             


Thr Gln  Ser Leu Ser Glu Leu  Glu Ala Gln Phe Leu  Arg Met Ser 
    4685                 4690                 4695             


Lys Val  Pro Thr Asp Leu Ala  Val Glu Glu Ala Leu  Ser Leu Gln 
    4700                 4705                 4710             


Asp Gly  Cys Arg Ala Ile Leu  Asp Glu Val Ala Gly  Leu Gly Glu 
    4715                 4720                 4725             


Ala Val  Asp Glu Leu Asn Gln  Lys Lys Glu Gly Phe  Arg Ser Thr 
    4730                 4735                 4740             


Gly Gln  Pro Trp Gln Pro Asp  Lys Met Leu His Leu  Val Thr Leu 
    4745                 4750                 4755             


Tyr His  Arg Leu Lys Arg Gln  Thr Glu Gln Arg Val  Ser Leu Leu 
    4760                 4765                 4770             


Glu Asp  Thr Thr Ser Ala Tyr  Gln Glu His Glu Lys  Met Cys Gln 
    4775                 4780                 4785             


Gln Leu  Glu Arg Gln Leu Lys  Ser Val Lys Glu Glu  Gln Ser Lys 
    4790                 4795                 4800             


Val Asn  Glu Glu Thr Leu Pro  Ala Glu Glu Lys Leu  Lys Met Tyr 
    4805                 4810                 4815             


His Ser  Leu Ala Gly Ser Leu  Gln Asp Ser Gly Ile  Val Leu Lys 
    4820                 4825                 4830             


Arg Val  Thr Ile His Leu Glu  Asp Leu Ala Pro His  Leu Asp Pro 
    4835                 4840                 4845             


Leu Ala  Tyr Glu Lys Ala Arg  His Gln Ile Gln Ser  Trp Gln Gly 
    4850                 4855                 4860             


Glu Leu  Lys Leu Leu Thr Ser  Ala Ile Gly Glu Thr  Val Thr Glu 
    4865                 4870                 4875             


Cys Glu  Ser Arg Met Val Gln  Ser Ile Asp Phe Gln  Thr Glu Met 
    4880                 4885                 4890             


Ser Arg  Ser Leu Asp Trp Leu  Arg Arg Val Lys Ala  Glu Leu Ser 
    4895                 4900                 4905             


Gly Pro  Val Tyr Leu Asp Leu  Asn Leu Gln Asp Ile  Gln Glu Glu 
    4910                 4915                 4920             


Ile Arg  Lys Ile Gln Ile His  Gln Glu Glu Val Gln  Ser Ser Leu 
    4925                 4930                 4935             


Arg Ile  Met Asn Ala Leu Ser  His Lys Glu Lys Glu  Lys Phe Thr 
    4940                 4945                 4950             


Lys Ala  Lys Glu Leu Ile Ser  Ala Asp Leu Glu His  Ser Leu Ala 
    4955                 4960                 4965             


Glu Leu  Ser Glu Leu Asp Gly  Asp Ile Gln Glu Ala  Leu Arg Thr 
    4970                 4975                 4980             


Arg Gln  Ala Thr Leu Thr Glu  Ile Tyr Ser Gln Cys  Gln Arg Tyr 
    4985                 4990                 4995             


Tyr Gln  Val Phe Gln Ala Ala  Asn Asp Trp Leu Glu  Asp Ala Gln 
    5000                 5005                 5010             


Glu Leu  Leu Gln Leu Ala Gly  Asn Gly Leu Asp Val  Glu Ser Ala 
    5015                 5020                 5025             


Glu Glu  Asn Leu Lys Ser His  Met Glu Phe Phe Ser  Thr Glu Asp 
    5030                 5035                 5040             


Gln Phe  His Ser Asn Leu Glu  Glu Leu His Ser Leu  Val Ala Thr 
    5045                 5050                 5055             


Leu Asp  Pro Leu Ile Lys Pro  Thr Gly Lys Glu Asp  Leu Glu Gln 
    5060                 5065                 5070             


Lys Val  Ala Ser Leu Glu Leu  Arg Ser Gln Arg Met  Ser Arg Asp 
    5075                 5080                 5085             


Ser Gly  Ala Gln Val Asp Leu  Leu Gln Arg Cys Thr  Ala Gln Trp 
    5090                 5095                 5100             


His Asp  Tyr Gln Lys Ala Arg  Glu Glu Val Ile Glu  Leu Met Asn 
    5105                 5110                 5115             


Asp Thr  Glu Lys Lys Leu Ser  Glu Phe Ser Leu Leu  Lys Thr Ser 
    5120                 5125                 5130             


Ser Ser  His Glu Ala Glu Glu  Lys Leu Ser Glu His  Lys Ala Leu 
    5135                 5140                 5145             


Val Ser  Val Val Asn Ser Phe  His Glu Lys Ile Val  Ala Leu Glu 
    5150                 5155                 5160             


Glu Lys  Ala Ser Gln Leu Glu  Lys Thr Gly Asn Asp  Ala Ser Lys 
    5165                 5170                 5175             


Ala Thr  Leu Ser Arg Ser Met  Thr Thr Val Trp Gln  Arg Trp Thr 
    5180                 5185                 5190             


Arg Leu  Arg Ala Val Ala Gln  Asp Gln Glu Lys Ile  Leu Glu Asp 
    5195                 5200                 5205             


Ala Val  Asp Glu Trp Thr Gly  Phe Asn Asn Lys Val  Lys Lys Ala 
    5210                 5215                 5220             


Thr Glu  Met Ile Asp Gln Leu  Gln Asp Lys Leu Pro  Gly Ser Ser 
    5225                 5230                 5235             


Ala Glu  Lys Ala Ser Lys Ala  Glu Leu Leu Thr Leu  Leu Glu Tyr 
    5240                 5245                 5250             


His Asp  Thr Phe Val Leu Glu  Leu Glu Gln Gln Gln  Ser Ala Leu 
    5255                 5260                 5265             


Gly Met  Leu Arg Gln Gln Thr  Leu Ser Met Leu Gln  Asp Gly Ala 
    5270                 5275                 5280             


Ala Pro  Thr Pro Gly Glu Glu  Pro Pro Leu Met Gln  Glu Ile Thr 
    5285                 5290                 5295             


Ala Met  Gln Asp Arg Cys Leu  Asn Met Gln Glu Lys  Val Lys Thr 
    5300                 5305                 5310             


Asn Gly  Lys Leu Val Lys Gln  Glu Leu Lys Asp Arg  Glu Met Val 
    5315                 5320                 5325             


Glu Thr  Gln Ile Asn Ser Val  Lys Cys Trp Val Gln  Glu Thr Lys 
    5330                 5335                 5340             


Glu Tyr  Leu Gly Asn Pro Thr  Ile Glu Ile Asp Ala  Gln Leu Glu 
    5345                 5350                 5355             


Glu Leu  Gln Ile Leu Leu Thr  Glu Ala Thr Asn His  Arg Gln Asn 
    5360                 5365                 5370             


Ile Glu  Lys Met Ala Glu Glu  Gln Lys Glu Lys Tyr  Leu Gly Leu 
    5375                 5380                 5385             


Tyr Thr  Ile Leu Pro Ser Glu  Leu Ser Leu Gln Leu  Ala Glu Val 
    5390                 5395                 5400             


Ala Leu  Asp Leu Lys Ile Arg  Asp Gln Ile Gln Asp  Lys Ile Lys 
    5405                 5410                 5415             


Glu Val  Glu Gln Ser Lys Ala  Thr Ser Gln Glu Leu  Ser Arg Gln 
    5420                 5425                 5430             


Ile Gln  Lys Leu Ala Lys Asp  Leu Thr Thr Ile Leu  Thr Lys Leu 
    5435                 5440                 5445             


Lys Ala  Lys Thr Asp Asn Val  Val Gln Ala Lys Thr  Asp Gln Lys 
    5450                 5455                 5460             


Val Leu  Gly Glu Glu Leu Asp  Gly Cys Asn Ser Lys  Leu Met Glu 
    5465                 5470                 5475             


Leu Asp  Ala Ala Val Gln Lys  Phe Leu Glu Gln Asn  Gly Gln Leu 
    5480                 5485                 5490             


Gly Lys  Pro Leu Ala Lys Lys  Ile Gly Lys Leu Thr  Glu Leu His 
    5495                 5500                 5505             


Gln Gln  Thr Ile Arg Gln Ala  Glu Asn Arg Leu Ser  Lys Leu Asn 
    5510                 5515                 5520             


Gln Ala  Ala Ser His Leu Glu  Glu Tyr Asn Glu Met  Leu Glu Leu 
    5525                 5530                 5535             


Ile Leu  Lys Trp Ile Glu Lys  Ala Lys Val Leu Ala  His Gly Thr 
    5540                 5545                 5550             


Ile Ala  Trp Asn Ser Ala Ser  Gln Leu Arg Glu Gln  Tyr Ile Leu 
    5555                 5560                 5565             


His Gln  Thr Leu Leu Glu Glu  Ser Lys Glu Ile Asp  Ser Glu Leu 
    5570                 5575                 5580             


Glu Ala  Met Thr Glu Lys Leu  Gln Tyr Leu Thr Ser  Val Tyr Cys 
    5585                 5590                 5595             


Thr Glu  Lys Met Ser Gln Gln  Val Ala Glu Leu Gly  Arg Glu Thr 
    5600                 5605                 5610             


Glu Glu  Leu Arg Gln Met Ile  Lys Ile Arg Leu Gln  Asn Leu Gln 
    5615                 5620                 5625             


Asp Ala  Ala Lys Asp Met Lys  Lys Phe Glu Ala Glu  Leu Lys Lys 
    5630                 5635                 5640             


Leu Gln  Ala Ala Leu Glu Gln  Ala Gln Ala Thr Leu  Thr Ser Pro 
    5645                 5650                 5655             


Glu Val  Gly Arg Leu Ser Leu  Lys Glu Gln Leu Ser  His Arg Gln 
    5660                 5665                 5670             


His Leu  Leu Ser Glu Met Glu  Ser Leu Lys Pro Lys  Val Gln Ala 
    5675                 5680                 5685             


Val Gln  Leu Cys Gln Ser Ala  Leu Arg Ile Pro Glu  Asp Val Val 
    5690                 5695                 5700             


Ala Ser  Leu Pro Leu Cys His  Ala Ala Leu Arg Leu  Gln Glu Glu 
    5705                 5710                 5715             


Ala Ser  Arg Leu Gln His Thr  Ala Ile Gln Gln Cys  Asn Ile Met 
    5720                 5725                 5730             


Gln Ala  Ala Val Val Gln Tyr  Glu Gln Tyr Glu Gln  Glu Met Lys 
    5735                 5740                 5745             


His Leu  Gln Gln Leu Ile Glu  Gly Ala His Arg Glu  Ile Glu Asp 
    5750                 5755                 5760             


Lys Pro  Val Ala Thr Ser Asn  Ile Gln Glu Leu Gln  Ala Gln Ile 
    5765                 5770                 5775             


Ser Arg  His Glu Glu Leu Ala  Gln Lys Ile Lys Gly  Tyr Gln Glu 
    5780                 5785                 5790             


Gln Ile  Ala Ser Leu Asn Ser  Lys Cys Lys Met Leu  Thr Met Lys 
    5795                 5800                 5805             


Ala Lys  His Ala Thr Met Leu  Leu Thr Val Thr Glu  Val Glu Gly 
    5810                 5815                 5820             


Leu Ala  Glu Gly Thr Glu Asp  Leu Asp Gly Glu Leu  Leu Pro Thr 
    5825                 5830                 5835             


Pro Ser  Ala His Pro Ser Val  Val Met Met Thr Ala  Gly Arg Cys 
    5840                 5845                 5850             


His Thr  Leu Leu Ser Pro Val  Thr Glu Glu Ser Gly  Glu Glu Gly 
    5855                 5860                 5865             


Thr Asn  Ser Glu Ile Ser Ser  Pro Pro Ala Cys Arg  Ser Pro Ser 
    5870                 5875                 5880             


Pro Val  Ala Asn Thr Asp Ala  Ser Val Asn Gln Asp  Ile Ala Tyr 
    5885                 5890                 5895             


Tyr Gln  Ala Leu Ser Ala Glu  Arg Leu Gln Thr Asp  Ala Ala Lys 
    5900                 5905                 5910             


Ile His  Pro Ser Thr Ser Ala  Ser Gln Glu Phe Tyr  Glu Pro Gly 
    5915                 5920                 5925             


Leu Glu  Pro Ser Ala Thr Ala  Lys Leu Gly Asp Leu  Gln Arg Ser 
    5930                 5935                 5940             


Trp Glu  Thr Leu Lys Asn Val  Ile Ser Glu Lys Gln  Arg Thr Leu 
    5945                 5950                 5955             


Tyr Glu  Ala Leu Glu Arg Gln  Gln Lys Tyr Gln Asp  Ser Leu Gln 
    5960                 5965                 5970             


Ser Ile  Ser Thr Lys Met Glu  Ala Ile Glu Leu Lys  Leu Ser Glu 
    5975                 5980                 5985             


Ser Pro  Glu Pro Gly Arg Ser  Pro Glu Ser Gln Met  Ala Glu His 
    5990                 5995                 6000             


Gln Ala  Leu Met Asp Glu Ile  Leu Met Leu Gln Asp  Glu Ile Asn 
    6005                 6010                 6015             


Glu Leu  Gln Ser Ser Leu Ala  Glu Glu Leu Val Ser  Glu Ser Cys 
    6020                 6025                 6030             


Glu Ala  Asp Pro Ala Glu Gln  Leu Ala Leu Gln Ser  Thr Leu Thr 
    6035                 6040                 6045             


Val Leu  Ala Glu Arg Met Ser  Thr Ile Arg Met Lys  Ala Ser Gly 
    6050                 6055                 6060             


Lys Arg  Gln Leu Leu Glu Glu  Lys Leu Asn Asp Gln  Leu Glu Glu 
    6065                 6070                 6075             


Gln Arg  Gln Glu Gln Ala Leu  Gln Arg Tyr Arg Cys  Glu Ala Asp 
    6080                 6085                 6090             


Glu Leu  Asp Ser Trp Leu Leu  Ser Thr Lys Ala Thr  Leu Asp Thr 
    6095                 6100                 6105             


Ala Leu  Ser Pro Pro Lys Glu  Pro Met Asp Met Glu  Ala Gln Leu 
    6110                 6115                 6120             


Met Asp  Cys Gln Asn Met Leu  Val Glu Ile Glu Gln  Lys Val Val 
    6125                 6130                 6135             


Ala Leu  Ser Glu Leu Ser Val  His Asn Glu Asn Leu  Leu Leu Glu 
    6140                 6145                 6150             


Gly Lys  Ala His Thr Lys Asp  Glu Ala Glu Gln Leu  Ala Gly Lys 
    6155                 6160                 6165             


Leu Arg  Arg Leu Lys Gly Ser  Leu Leu Glu Leu Gln  Arg Ala Leu 
    6170                 6175                 6180             


His Asp  Lys Gln Leu Asn Met  Gln Gly Thr Ala Gln  Glu Lys Glu 
    6185                 6190                 6195             


Glu Ser  Asp Val Asp Leu Thr  Ala Thr Gln Ser Pro  Gly Val Gln 
    6200                 6205                 6210             


Glu Trp  Leu Ala Gln Ala Arg  Thr Thr Trp Thr Gln  Gln Arg Gln 
    6215                 6220                 6225             


Ser Ser  Leu Gln Gln Gln Lys  Glu Leu Glu Gln Glu  Leu Ala Glu 
    6230                 6235                 6240             


Gln Lys  Ser Leu Leu Arg Ser  Val Ala Ser Arg Gly  Glu Glu Ile 
    6245                 6250                 6255             


Leu Ile  Gln His Ser Ala Ala  Glu Thr Ser Gly Asp  Ala Gly Glu 
    6260                 6265                 6270             


Lys Pro  Asp Val Leu Ser Gln  Glu Leu Gly Met Glu  Gly Glu Lys 
    6275                 6280                 6285             


Ser Ser  Ala Glu Asp Gln Met  Arg Met Lys Trp Glu  Ser Leu His 
    6290                 6295                 6300             


Gln Glu  Phe Ser Thr Lys Gln  Lys Leu Leu Gln Asn  Val Leu Glu 
    6305                 6310                 6315             


Gln Glu  Gln Glu Gln Val Leu  Tyr Ser Arg Pro Asn  Arg Leu Leu 
    6320                 6325                 6330             


Ser Gly  Val Pro Leu Tyr Lys  Gly Asp Val Pro Thr  Gln Asp Lys 
    6335                 6340                 6345             


Ser Ala  Val Thr Ser Leu Leu  Asp Gly Leu Asn Gln  Ala Phe Glu 
    6350                 6355                 6360             


Glu Val  Ser Ser Gln Ser Gly  Gly Ala Lys Arg Gln  Ser Ile His 
    6365                 6370                 6375             


Leu Glu  Gln Lys Leu Tyr Asp  Gly Val Ser Ala Thr  Ser Thr Trp 
    6380                 6385                 6390             


Leu Asp  Asp Val Glu Glu Arg  Leu Phe Val Ala Thr  Ala Leu Leu 
    6395                 6400                 6405             


Pro Glu  Glu Thr Glu Thr Cys  Leu Phe Asn Gln Glu  Ile Leu Ala 
    6410                 6415                 6420             


Lys Asp  Ile Lys Glu Met Ser  Glu Glu Met Asp Lys  Asn Lys Asn 
    6425                 6430                 6435             


Leu Phe  Ser Gln Ala Phe Pro  Glu Asn Gly Asp Asn  Arg Asp Val 
    6440                 6445                 6450             


Ile Glu  Asp Thr Leu Gly Cys  Leu Leu Gly Arg Leu  Ser Leu Leu 
    6455                 6460                 6465             


Asp Ser  Val Val Asn Gln Arg  Cys His Gln Met Lys  Glu Arg Leu 
    6470                 6475                 6480             


Gln Gln  Ile Leu Asn Phe Gln  Asn Asp Leu Lys Val  Leu Phe Thr 
    6485                 6490                 6495             


Ser Leu  Ala Asp Asn Lys Tyr  Ile Ile Leu Gln Lys  Leu Ala Asn 
    6500                 6505                 6510             


Val Phe  Glu Gln Pro Val Ala  Glu Gln Ile Glu Ala  Ile Gln Gln 
    6515                 6520                 6525             


Ala Glu  Asp Gly Leu Lys Glu  Phe Asp Ala Gly Ile  Ile Glu Leu 
    6530                 6535                 6540             


Lys Arg  Arg Gly Asp Lys Leu  Gln Val Glu Gln Pro  Ser Met Gln 
    6545                 6550                 6555             


Glu Leu  Ser Lys Leu Gln Asp  Met Tyr Asp Glu Leu  Met Met Ile 
    6560                 6565                 6570             


Ile Gly  Ser Arg Arg Ser Gly  Leu Asn Gln Asn Leu  Thr Leu Lys 
    6575                 6580                 6585             


Ser Gln  Tyr Glu Arg Ala Leu  Gln Asp Leu Ala Asp  Leu Leu Glu 
    6590                 6595                 6600             


Thr Gly  Gln Glu Lys Met Ala  Gly Asp Gln Lys Ile  Ile Val Ser 
    6605                 6610                 6615             


Ser Lys  Glu Glu Ile Gln Gln  Leu Leu Asp Lys His  Lys Glu Tyr 
    6620                 6625                 6630             


Phe Gln  Gly Leu Glu Ser His  Met Ile Leu Thr Glu  Thr Leu Phe 
    6635                 6640                 6645             


Arg Lys  Ile Ile Ser Phe Ala  Val Gln Lys Glu Thr  Gln Phe His 
    6650                 6655                 6660             


Thr Glu  Leu Met Ala Gln Ala  Ser Ala Val Leu Lys  Arg Ala His 
    6665                 6670                 6675             


Lys Arg  Gly Val Glu Leu Glu  Tyr Ile Leu Glu Thr  Trp Ser His 
    6680                 6685                 6690             


Leu Asp  Glu Asp Gln Gln Glu  Leu Ser Arg Gln Leu  Glu Val Val 
    6695                 6700                 6705             


Glu Ser  Ser Ile Pro Ser Val  Gly Leu Val Glu Glu  Asn Glu Asp 
    6710                 6715                 6720             


Arg Leu  Ile Asp Arg Ile Thr  Leu Tyr Gln His Leu  Lys Ser Ser 
    6725                 6730                 6735             


Leu Asn  Glu Tyr Gln Pro Lys  Leu Tyr Gln Val Leu  Asp Asp Gly 
    6740                 6745                 6750             


Lys Arg  Leu Leu Ile Ser Ile  Ser Cys Ser Asp Leu  Glu Ser Gln 
    6755                 6760                 6765             


Leu Asn  Gln Leu Gly Glu Cys  Trp Leu Ser Asn Thr  Asn Lys Met 
    6770                 6775                 6780             


Ser Lys  Glu Leu His Arg Leu  Glu Thr Ile Leu Lys  His Trp Thr 
    6785                 6790                 6795             


Arg Tyr  Gln Ser Glu Ser Ala  Asp Leu Ile His Trp  Leu Gln Ser 
    6800                 6805                 6810             


Ala Lys  Asp Arg Leu Glu Phe  Trp Thr Gln Gln Ser  Val Thr Val 
    6815                 6820                 6825             


Pro Gln  Glu Leu Glu Met Val  Arg Asp His Leu Asn  Ala Phe Leu 
    6830                 6835                 6840             


Glu Phe  Ser Lys Glu Val Asp  Ala Gln Ser Ser Leu  Lys Ser Ser 
    6845                 6850                 6855             


Val Leu  Ser Thr Gly Asn Gln  Leu Leu Arg Leu Lys  Lys Val Asp 
    6860                 6865                 6870             


Thr Ala  Thr Leu Arg Ser Glu  Leu Ser Arg Ile Asp  Ser Gln Trp 
    6875                 6880                 6885             


Thr Asp  Leu Leu Thr Asn Ile  Pro Ala Val Gln Glu  Lys Leu His 
    6890                 6895                 6900             


Gln Leu  Gln Met Asp Lys Leu  Pro Ser Arg His Ala  Ile Ser Glu 
    6905                 6910                 6915             


Val Met  Ser Trp Ile Ser Leu  Met Glu Asn Val Ile  Gln Lys Asp 
    6920                 6925                 6930             


Glu Asp  Asn Ile Lys Asn Ser  Ile Gly Tyr Lys Ala  Ile His Glu 
    6935                 6940                 6945             


Tyr Leu  Gln Lys Tyr Lys Gly  Phe Lys Ile Asp Ile  Asn Cys Lys 
    6950                 6955                 6960             


Gln Leu  Thr Val Asp Phe Val  Asn Gln Ser Val Leu  Gln Ile Ser 
    6965                 6970                 6975             


Ser Gln  Asp Val Glu Ser Lys  Arg Ser Asp Lys Thr  Asp Phe Ala 
    6980                 6985                 6990             


Glu Gln  Leu Gly Ala Met Asn  Lys Ser Trp Gln Ile  Leu Gln Gly 
    6995                 7000                 7005             


Leu Val  Thr Glu Lys Ile Gln  Leu Leu Glu Gly Leu  Leu Glu Ser 
    7010                 7015                 7020             


Trp Ser  Glu Tyr Glu Asn Asn  Val Gln Cys Leu Lys  Thr Trp Phe 
    7025                 7030                 7035             


Glu Thr  Gln Glu Lys Arg Leu  Lys Gln Gln His Arg  Ile Gly Asp 
    7040                 7045                 7050             


Gln Ala  Ser Val Gln Asn Ala  Leu Lys Asp Cys Gln  Asp Leu Glu 
    7055                 7060                 7065             


Asp Leu  Ile Lys Ala Lys Glu  Lys Glu Val Glu Lys  Ile Glu Gln 
    7070                 7075                 7080             


Asn Gly  Leu Ala Leu Ile Gln  Asn Lys Lys Glu Asp  Val Ser Ser 
    7085                 7090                 7095             


Ile Val  Met Ser Thr Leu Arg  Glu Leu Gly Gln Thr  Trp Ala Asn 
    7100                 7105                 7110             


Leu Asp  His Met Val Gly Gln  Leu Lys Ile Leu Leu  Lys Ser Val 
    7115                 7120                 7125             


Leu Asp  Gln Trp Ser Ser His  Lys Val Ala Phe Asp  Lys Ile Asn 
    7130                 7135                 7140             


Ser Tyr  Leu Met Glu Ala Arg  Tyr Ser Leu Ser Arg  Phe Arg Leu 
    7145                 7150                 7155             


Leu Thr  Gly Ser Leu Glu Ala  Val Gln Val Gln Val  Asp Asn Leu 
    7160                 7165                 7170             


Gln Asn  Leu Gln Asp Asp Leu  Glu Lys Gln Glu Arg  Ser Leu Gln 
    7175                 7180                 7185             


Lys Phe  Gly Ser Ile Thr Asn  Gln Leu Leu Lys Glu  Cys His Pro 
    7190                 7195                 7200             


Pro Val  Thr Glu Thr Leu Thr  Asn Thr Leu Lys Glu  Val Asn Met 
    7205                 7210                 7215             


Arg Trp  Asn Asn Leu Leu Glu  Glu Ile Ala Glu Gln  Leu Gln Ser 
    7220                 7225                 7230             


Ser Lys  Ala Leu Leu Gln Leu  Trp Gln Arg Tyr Lys  Asp Tyr Ser 
    7235                 7240                 7245             


Lys Gln  Cys Ala Ser Thr Val  Gln Gln Gln Glu Asp  Arg Thr Asn 
    7250                 7255                 7260             


Glu Leu  Leu Lys Ala Ala Thr  Asn Lys Asp Ile Ala  Asp Asp Glu 
    7265                 7270                 7275             


Val Ala  Thr Trp Ile Gln Asp  Cys Asn Asp Leu Leu  Lys Gly Leu 
    7280                 7285                 7290             


Gly Thr  Val Lys Asp Ser Leu  Phe Phe Leu His Glu  Leu Gly Glu 
    7295                 7300                 7305             


Gln Leu  Lys Gln Gln Val Asp  Ala Ser Ala Ala Ser  Ala Ile Gln 
    7310                 7315                 7320             


Ser Asp  Gln Leu Ser Leu Ser  Gln His Leu Cys Ala  Leu Glu Gln 
    7325                 7330                 7335             


Ala Leu  Cys Lys Gln Gln Thr  Ser Leu Gln Ala Gly  Val Leu Asp 
    7340                 7345                 7350             


Tyr Glu  Thr Phe Ala Lys Ser  Leu Glu Ala Leu Glu  Ala Trp Ile 
    7355                 7360                 7365             


Val Glu  Ala Glu Glu Ile Leu  Gln Gly Gln Asp Pro  Ser His Ser 
    7370                 7375                 7380             


Ser Asp  Leu Ser Thr Ile Gln  Glu Arg Met Glu Glu  Leu Lys Gly 
    7385                 7390                 7395             


Gln Met  Leu Lys Phe Ser Ser  Met Ala Pro Asp Leu  Asp Arg Leu 
    7400                 7405                 7410             


Asn Glu  Leu Gly Tyr Arg Leu  Pro Leu Asn Asp Lys  Glu Ile Lys 
    7415                 7420                 7425             


Arg Met  Gln Asn Leu Asn Arg  His Trp Ser Leu Ile  Ser Ser Gln 
    7430                 7435                 7440             


Thr Thr  Glu Arg Phe Ser Lys  Leu Gln Ser Phe Leu  Leu Gln His 
    7445                 7450                 7455             


Gln Thr  Phe Leu Glu Lys Cys  Glu Thr Trp Met Glu  Phe Leu Val 
    7460                 7465                 7470             


Gln Thr  Glu Gln Lys Leu Ala  Val Glu Ile Ser Gly  Asn Tyr Gln 
    7475                 7480                 7485             


His Leu  Leu Glu Gln Gln Arg  Ala His Glu Leu Phe  Gln Ala Glu 
    7490                 7495                 7500             


Met Phe  Ser Arg Gln Gln Ile  Leu His Ser Ile Ile  Ile Asp Gly 
    7505                 7510                 7515             


Gln Arg  Leu Leu Glu Gln Gly  Gln Val Asp Asp Arg  Asp Glu Phe 
    7520                 7525                 7530             


Asn Leu  Lys Leu Thr Leu Leu  Ser Asn Gln Trp Gln  Gly Val Ile 
    7535                 7540                 7545             


Arg Arg  Ala Gln Gln Arg Arg  Gly Ile Ile Asp Ser  Gln Ile Arg 
    7550                 7555                 7560             


Gln Trp  Gln Arg Tyr Arg Glu  Met Ala Glu Lys Leu  Arg Lys Trp 
    7565                 7570                 7575             


Leu Val  Glu Val Ser Tyr Leu  Pro Met Ser Gly Leu  Gly Ser Val 
    7580                 7585                 7590             


Pro Ile  Pro Leu Gln Gln Ala  Arg Thr Leu Phe Asp  Glu Val Gln 
    7595                 7600                 7605             


Phe Lys  Glu Lys Val Phe Leu  Arg Gln Gln Gly Ser  Tyr Ile Leu 
    7610                 7615                 7620             


Thr Val  Glu Ala Gly Lys Gln  Leu Leu Leu Ser Ala  Asp Ser Gly 
    7625                 7630                 7635             


Ala Glu  Ala Ala Leu Gln Ala  Glu Leu Ala Glu Ile  Gln Glu Lys 
    7640                 7645                 7650             


Trp Lys  Ser Ala Ser Met Arg  Leu Glu Glu Gln Lys  Lys Lys Leu 
    7655                 7660                 7665             


Ala Phe  Leu Leu Lys Asp Trp  Glu Lys Cys Glu Lys  Gly Ile Ala 
    7670                 7675                 7680             


Asp Ser  Leu Glu Lys Leu Arg  Thr Phe Lys Lys Lys  Leu Ser Gln 
    7685                 7690                 7695             


Ser Leu  Pro Asp His His Glu  Glu Leu His Ala Glu  Gln Met Arg 
    7700                 7705                 7710             


Cys Lys  Glu Leu Glu Asn Ala  Val Gly Ser Trp Thr  Asp Asp Leu 
    7715                 7720                 7725             


Thr Gln  Leu Ser Leu Leu Lys  Asp Thr Leu Ser Ala  Tyr Ile Ser 
    7730                 7735                 7740             


Ala Asp  Asp Ile Ser Ile Leu  Asn Glu Arg Val Glu  Leu Leu Gln 
    7745                 7750                 7755             


Arg Gln  Trp Glu Glu Leu Cys  His Gln Leu Ser Leu  Arg Arg Gln 
    7760                 7765                 7770             


Gln Ile  Gly Glu Arg Leu Asn  Glu Trp Ala Val Phe  Ser Glu Lys 
    7775                 7780                 7785             


Asn Lys  Glu Leu Cys Glu Trp  Leu Thr Gln Met Glu  Ser Lys Val 
    7790                 7795                 7800             


Ser Gln  Asn Gly Asp Ile Leu  Ile Glu Glu Met Ile  Glu Lys Leu 
    7805                 7810                 7815             


Lys Lys  Asp Tyr Gln Glu Glu  Ile Ala Ile Ala Gln  Glu Asn Lys 
    7820                 7825                 7830             


Ile Gln  Leu Gln Gln Met Gly  Glu Arg Leu Ala Lys  Ala Ser His 
    7835                 7840                 7845             


Glu Ser  Lys Ala Ser Glu Ile  Glu Tyr Lys Leu Gly  Lys Val Asn 
    7850                 7855                 7860             


Asp Arg  Trp Gln His Leu Leu  Asp Leu Ile Ala Ala  Arg Val Lys 
    7865                 7870                 7875             


Lys Leu  Lys Glu Thr Leu Val  Ala Val Gln Gln Leu  Asp Lys Asn 
    7880                 7885                 7890             


Met Ser  Ser Leu Arg Thr Trp  Leu Ala His Ile Glu  Ser Glu Leu 
    7895                 7900                 7905             


Ala Lys  Pro Ile Val Tyr Asp  Ser Cys Asn Ser Glu  Glu Ile Gln 
    7910                 7915                 7920             


Arg Lys  Leu Asn Glu Gln Gln  Glu Leu Gln Arg Asp  Ile Glu Lys 
    7925                 7930                 7935             


His Ser  Thr Gly Val Ala Ser  Val Leu Asn Leu Cys  Glu Val Leu 
    7940                 7945                 7950             


Leu His  Asp Cys Asp Ala Cys  Ala Thr Asp Ala Glu  Cys Asp Ser 
    7955                 7960                 7965             


Ile Gln  Gln Ala Thr Arg Asn  Leu Asp Arg Arg Trp  Arg Asn Ile 
    7970                 7975                 7980             


Cys Ala  Met Ser Met Glu Arg  Arg Leu Lys Ile Glu  Glu Thr Trp 
    7985                 7990                 7995             


Arg Leu  Trp Gln Lys Phe Leu  Asp Asp Tyr Ser Arg  Phe Glu Asp 
    8000                 8005                 8010             


Trp Leu  Lys Ser Ser Glu Arg  Thr Ala Ala Phe Pro  Ser Ser Ser 
    8015                 8020                 8025             


Gly Val  Ile Tyr Thr Val Ala  Lys Glu Glu Leu Lys  Lys Phe Glu 
    8030                 8035                 8040             


Ala Phe  Gln Arg Gln Val His  Glu Cys Leu Thr Gln  Leu Glu Leu 
    8045                 8050                 8055             


Ile Asn  Lys Gln Tyr Arg Arg  Leu Ala Arg Glu Asn  Arg Thr Asp 
    8060                 8065                 8070             


Ser Ala  Cys Ser Leu Lys Gln  Met Val His Glu Gly  Asn Gln Arg 
    8075                 8080                 8085             


Trp Asp  Asn Leu Gln Lys Arg  Val Thr Ser Ile Leu  Arg Arg Leu 
    8090                 8095                 8100             


Lys His  Phe Ile Gly Gln Arg  Glu Glu Phe Glu Thr  Ala Arg Asp 
    8105                 8110                 8115             


Ser Ile  Leu Val Trp Leu Thr  Glu Met Asp Leu Gln  Leu Thr Asn 
    8120                 8125                 8130             


Ile Glu  His Phe Ser Glu Cys  Asp Val Gln Ala Lys  Ile Lys Gln 
    8135                 8140                 8145             


Leu Lys  Ala Phe Gln Gln Glu  Ile Ser Leu Asn His  Asn Lys Ile 
    8150                 8155                 8160             


Glu Gln  Ile Ile Ala Gln Gly  Glu Gln Leu Ile Glu  Lys Ser Glu 
    8165                 8170                 8175             


Pro Leu  Asp Ala Ala Ile Ile  Glu Glu Glu Leu Asp  Glu Leu Arg 
    8180                 8185                 8190             


Arg Tyr  Cys Gln Glu Val Phe  Gly Arg Val Glu Arg  Tyr His Lys 
    8195                 8200                 8205             


Lys Leu  Ile Arg Leu Pro Leu  Pro Asp Asp Glu His  Asp Leu Ser 
    8210                 8215                 8220             


Asp Arg  Glu Leu Glu Leu Glu  Asp Ser Ala Ala Leu  Ser Asp Leu 
    8225                 8230                 8235             


His Trp  His Asp Arg Ser Ala  Asp Ser Leu Leu Ser  Pro Gln Pro 
    8240                 8245                 8250             


Ser Ser  Asn Leu Ser Leu Ser  Leu Ala Gln Pro Leu  Arg Ser Glu 
    8255                 8260                 8265             


Arg Ser  Gly Arg Asp Thr Pro  Ala Ser Val Asp Ser  Ile Pro Leu 
    8270                 8275                 8280             


Glu Trp  Asp His Asp Tyr Asp  Leu Ser Arg Asp Leu  Glu Ser Ala 
    8285                 8290                 8295             


Met Ser  Arg Ala Leu Pro Ser  Glu Asp Glu Glu Gly  Gln Asp Asp 
    8300                 8305                 8310             


Lys Asp  Phe Tyr Leu Arg Gly  Ala Val Gly Leu Ser  Gly Asp His 
    8315                 8320                 8325             


Ser Ala  Leu Glu Ser Gln Ile  Arg Gln Leu Gly Lys  Ala Leu Asp 
    8330                 8335                 8340             


Asp Ser  Arg Phe Gln Ile Gln  Gln Thr Glu Asn Ile  Ile Arg Ser 
    8345                 8350                 8355             


Lys Thr  Pro Thr Gly Pro Glu  Leu Asp Thr Ser Tyr  Lys Gly Tyr 
    8360                 8365                 8370             


Met Lys  Leu Leu Gly Glu Cys  Ser Ser Ser Ile Asp  Ser Val Lys 
    8375                 8380                 8385             


Arg Leu  Glu His Lys Leu Lys  Glu Glu Glu Glu Ser  Leu Pro Gly 
    8390                 8395                 8400             


Phe Val  Asn Leu His Ser Thr  Glu Thr Gln Thr Ala  Gly Val Ile 
    8405                 8410                 8415             


Asp Arg  Trp Glu Leu Leu Gln  Ala Gln Ala Leu Ser  Lys Glu Leu 
    8420                 8425                 8430             


Arg Met  Lys Gln Asn Leu Gln  Lys Trp Gln Gln Phe  Asn Ser Asp 
    8435                 8440                 8445             


Leu Asn  Ser Ile Trp Ala Trp  Leu Gly Asp Thr Glu  Glu Glu Leu 
    8450                 8455                 8460             


Glu Gln  Leu Gln Arg Leu Glu  Leu Ser Thr Asp Ile  Gln Thr Ile 
    8465                 8470                 8475             


Glu Leu  Gln Ile Lys Lys Leu  Lys Glu Leu Gln Lys  Ala Val Asp 
    8480                 8485                 8490             


His Arg  Lys Ala Ile Ile Leu  Ser Ile Asn Leu Cys  Ser Pro Glu 
    8495                 8500                 8505             


Phe Thr  Gln Ala Asp Ser Lys  Glu Ser Arg Asp Leu  Gln Asp Arg 
    8510                 8515                 8520             


Leu Ser  Gln Met Asn Gly Arg  Trp Asp Arg Val Cys  Ser Leu Leu 
    8525                 8530                 8535             


Glu Glu  Trp Arg Gly Leu Leu  Gln Asp Ala Leu Met  Gln Cys Gln 
    8540                 8545                 8550             


Gly Phe  His Glu Met Ser His  Gly Leu Leu Leu Met  Leu Glu Asn 
    8555                 8560                 8565             


Ile Asp  Arg Arg Lys Asn Glu  Ile Val Pro Ile Asp  Ser Asn Leu 
    8570                 8575                 8580             


Asp Ala  Glu Ile Leu Gln Asp  His His Lys Gln Leu  Met Gln Ile 
    8585                 8590                 8595             


Lys His  Glu Leu Leu Glu Ser  Gln Leu Arg Val Ala  Ser Leu Gln 
    8600                 8605                 8610             


Asp Met  Ser Cys Gln Leu Leu  Val Asn Ala Glu Gly  Thr Asp Cys 
    8615                 8620                 8625             


Leu Glu  Ala Lys Glu Lys Val  His Val Ile Gly Asn  Arg Leu Lys 
    8630                 8635                 8640             


Leu Leu  Leu Lys Glu Val Ser  Arg His Ile Lys Glu  Leu Glu Lys 
    8645                 8650                 8655             


Leu Leu  Asp Val Ser Ser Ser  Gln Gln Asp Leu Ser  Ser Trp Ser 
    8660                 8665                 8670             


Ser Ala  Asp Glu Leu Asp Thr  Ser Gly Ser Val Ser  Pro Thr Ser 
    8675                 8680                 8685             


Gly Arg  Ser Thr Pro Asn Arg  Gln Lys Thr Pro Arg  Gly Lys Cys 
    8690                 8695                 8700             


Ser Leu  Ser Gln Pro Gly Pro  Ser Val Ser Ser Pro  His Ser Arg 
    8705                 8710                 8715             


Ser Thr  Lys Gly Gly Ser Asp  Ser Ser Leu Ser Glu  Pro Gly Pro 
    8720                 8725                 8730             


Gly Arg  Ser Gly Arg Gly Phe  Leu Phe Arg Val Leu  Arg Ala Ala 
    8735                 8740                 8745             


Leu Pro  Leu Gln Leu Leu Leu  Leu Leu Leu Ile Gly  Leu Ala Cys 
    8750                 8755                 8760             


Leu Val  Pro Met Ser Glu Glu  Asp Tyr Ser Cys Ala  Leu Ser Asn 
    8765                 8770                 8775             


Asn Phe  Ala Arg Ser Phe His  Pro Met Leu Arg Tyr  Thr Asn Gly 
    8780                 8785                 8790             


Pro Pro  Pro Leu 
    8795         


<210>  167
<211>  552
<212>  PRT
<213>  Homo sapiens

<400>  167

Met Gly Cys Ser Ala Lys Ala Arg Trp Ala Ala Gly Ala Leu Gly Val 
1               5                   10                  15      


Ala Gly Leu Leu Cys Ala Val Leu Gly Ala Val Met Ile Val Met Val 
            20                  25                  30          


Pro Ser Leu Ile Lys Gln Gln Val Leu Lys Asn Val Arg Ile Asp Pro 
        35                  40                  45              


Ser Ser Leu Ser Phe Asn Met Trp Lys Glu Ile Pro Ile Pro Phe Tyr 
    50                  55                  60                  


Leu Ser Val Tyr Phe Phe Asp Val Met Asn Pro Ser Glu Ile Leu Lys 
65                  70                  75                  80  


Gly Glu Lys Pro Gln Val Arg Glu Arg Gly Pro Tyr Val Tyr Arg Glu 
                85                  90                  95      


Phe Arg His Lys Ser Asn Ile Thr Phe Asn Asn Asn Asp Thr Val Ser 
            100                 105                 110         


Phe Leu Glu Tyr Arg Thr Phe Gln Phe Gln Pro Ser Lys Ser His Gly 
        115                 120                 125             


Ser Glu Ser Asp Tyr Ile Val Met Pro Asn Ile Leu Val Leu Gly Ala 
    130                 135                 140                 


Ala Val Met Met Glu Asn Lys Pro Met Thr Leu Lys Leu Ile Met Thr 
145                 150                 155                 160 


Leu Ala Phe Thr Thr Leu Gly Glu Arg Ala Phe Met Asn Arg Thr Val 
                165                 170                 175     


Gly Glu Ile Met Trp Gly Tyr Lys Asp Pro Leu Val Asn Leu Ile Asn 
            180                 185                 190         


Lys Tyr Phe Pro Gly Met Phe Pro Phe Lys Asp Lys Phe Gly Leu Phe 
        195                 200                 205             


Ala Glu Leu Asn Asn Ser Asp Ser Gly Leu Phe Thr Val Phe Thr Gly 
    210                 215                 220                 


Val Gln Asn Ile Ser Arg Ile His Leu Val Asp Lys Trp Asn Gly Leu 
225                 230                 235                 240 


Ser Lys Val Asp Phe Trp His Ser Asp Gln Cys Asn Met Ile Asn Gly 
                245                 250                 255     


Thr Ser Gly Gln Met Trp Pro Pro Phe Met Thr Pro Glu Ser Ser Leu 
            260                 265                 270         


Glu Phe Tyr Ser Pro Glu Ala Cys Arg Ser Met Lys Leu Met Tyr Lys 
        275                 280                 285             


Glu Ser Gly Val Phe Glu Gly Ile Pro Thr Tyr Arg Phe Val Ala Pro 
    290                 295                 300                 


Lys Thr Leu Phe Ala Asn Gly Ser Ile Tyr Pro Pro Asn Glu Gly Phe 
305                 310                 315                 320 


Cys Pro Cys Leu Glu Ser Gly Ile Gln Asn Val Ser Thr Cys Arg Phe 
                325                 330                 335     


Ser Ala Pro Leu Phe Leu Ser His Pro His Phe Leu Asn Ala Asp Pro 
            340                 345                 350         


Val Leu Ala Glu Ala Val Thr Gly Leu His Pro Asn Gln Glu Ala His 
        355                 360                 365             


Ser Leu Phe Leu Asp Ile His Pro Val Thr Gly Ile Pro Met Asn Cys 
    370                 375                 380                 


Ser Val Lys Leu Gln Leu Ser Leu Tyr Met Lys Ser Val Ala Gly Ile 
385                 390                 395                 400 


Gly Gln Thr Gly Lys Ile Glu Pro Val Val Leu Pro Leu Leu Trp Phe 
                405                 410                 415     


Ala Glu Ser Gly Ala Met Glu Gly Glu Thr Leu His Thr Phe Tyr Thr 
            420                 425                 430         


Gln Leu Val Leu Met Pro Lys Val Met His Tyr Ala Gln Tyr Val Leu 
        435                 440                 445             


Leu Ala Leu Gly Cys Val Leu Leu Leu Val Pro Val Ile Cys Gln Ile 
    450                 455                 460                 


Arg Ser Gln Val Gly Ala Gly Gln Arg Ala Ala Arg Ala Asp Ser His 
465                 470                 475                 480 


Ser Leu Ala Cys Trp Gly Lys Gly Ala Ser Asp Arg Thr Leu Trp Pro 
                485                 490                 495     


Thr Ala Ala Trp Ser Pro Pro Pro Ala Ala Val Leu Arg Leu Cys Arg 
            500                 505                 510         


Ser Gly Ser Gly His Cys Trp Gly Leu Arg Ser Thr Leu Ala Ser Phe 
        515                 520                 525             


Ala Cys Arg Val Ala Thr Thr Leu Pro Val Leu Glu Gly Leu Gly Pro 
    530                 535                 540                 


Ser Leu Gly Gly Gly Thr Gly Ser 
545                 550         


<210>  168
<211>  775
<212>  PRT
<213>  Homo sapiens

<400>  168

Met Ala Ser Arg Ala Val Val Arg Ala Arg Arg Cys Pro Gln Cys Pro 
1               5                   10                  15      


Gln Val Arg Ala Ala Ala Ala Ala Pro Ala Trp Ala Ala Leu Pro Leu 
            20                  25                  30          


Ser Arg Ser Leu Pro Pro Cys Ser Asn Ser Ser Ser Phe Ser Met Pro 
        35                  40                  45              


Leu Phe Leu Leu Leu Leu Leu Val Leu Leu Leu Leu Leu Glu Asp Ala 
    50                  55                  60                  


Gly Ala Gln Gln Gly Asp Gly Cys Gly His Thr Val Leu Gly Pro Glu 
65                  70                  75                  80  


Ser Gly Thr Leu Thr Ser Ile Asn Tyr Pro Gln Thr Tyr Pro Asn Ser 
                85                  90                  95      


Thr Val Cys Glu Trp Glu Ile Arg Val Lys Met Gly Glu Arg Val Arg 
            100                 105                 110         


Ile Lys Phe Gly Asp Phe Asp Ile Glu Asp Ser Asp Ser Cys His Phe 
        115                 120                 125             


Asn Tyr Leu Arg Ile Tyr Asn Gly Ile Gly Val Ser Arg Thr Glu Ile 
    130                 135                 140                 


Gly Lys Tyr Cys Gly Leu Gly Leu Gln Met Asn His Ser Ile Glu Ser 
145                 150                 155                 160 


Lys Gly Asn Glu Ile Thr Leu Leu Phe Met Ser Gly Ile His Val Ser 
                165                 170                 175     


Gly Arg Gly Phe Leu Ala Ser Tyr Ser Val Ile Asp Lys Gln Asp Leu 
            180                 185                 190         


Ile Thr Cys Leu Asp Thr Ala Ser Asn Phe Leu Glu Pro Glu Phe Ser 
        195                 200                 205             


Lys Tyr Cys Pro Ala Gly Cys Leu Leu Pro Phe Ala Glu Ile Ser Gly 
    210                 215                 220                 


Thr Ile Pro His Gly Tyr Arg Asp Ser Ser Pro Leu Cys Met Ala Gly 
225                 230                 235                 240 


Val His Ala Gly Val Val Ser Asn Thr Leu Gly Gly Gln Ile Ser Val 
                245                 250                 255     


Val Ile Ser Lys Gly Ile Pro Tyr Tyr Glu Ser Ser Leu Ala Asn Asn 
            260                 265                 270         


Val Thr Ser Val Val Gly His Leu Ser Thr Ser Leu Phe Thr Phe Lys 
        275                 280                 285             


Thr Ser Gly Cys Tyr Gly Thr Leu Gly Met Glu Ser Gly Val Ile Ala 
    290                 295                 300                 


Asp Pro Gln Ile Thr Ala Ser Ser Val Leu Glu Trp Thr Asp His Thr 
305                 310                 315                 320 


Gly Gln Glu Asn Ser Trp Lys Pro Lys Lys Ala Arg Leu Lys Lys Pro 
                325                 330                 335     


Gly Pro Pro Trp Ala Ala Phe Ala Thr Asp Glu Tyr Gln Trp Leu Gln 
            340                 345                 350         


Ile Asp Leu Asn Lys Glu Lys Lys Ile Thr Gly Ile Ile Thr Thr Gly 
        355                 360                 365             


Ser Thr Met Val Glu His Asn Tyr Tyr Val Ser Ala Tyr Arg Ile Leu 
    370                 375                 380                 


Tyr Ser Asp Asp Gly Gln Lys Trp Thr Val Tyr Arg Glu Pro Gly Val 
385                 390                 395                 400 


Glu Gln Asp Lys Ile Phe Gln Gly Asn Lys Asp Tyr His Gln Asp Val 
                405                 410                 415     


Arg Asn Asn Phe Leu Pro Pro Ile Ile Ala Arg Phe Ile Arg Val Asn 
            420                 425                 430         


Pro Thr Gln Trp Gln Gln Lys Ile Ala Met Lys Met Glu Leu Leu Gly 
        435                 440                 445             


Cys Gln Phe Ile Pro Lys Gly Arg Pro Pro Lys Leu Thr Gln Pro Pro 
    450                 455                 460                 


Pro Pro Arg Asn Ser Asn Asp Leu Lys Asn Thr Thr Ala Pro Pro Lys 
465                 470                 475                 480 


Ile Ala Lys Gly Arg Ala Pro Lys Phe Thr Gln Pro Leu Gln Pro Arg 
                485                 490                 495     


Ser Ser Asn Glu Phe Pro Ala Gln Thr Glu Gln Thr Thr Ala Ser Pro 
            500                 505                 510         


Asp Ile Arg Asn Thr Thr Val Thr Pro Asn Val Thr Lys Asp Val Ala 
        515                 520                 525             


Leu Ala Ala Val Leu Val Pro Val Leu Val Met Val Leu Thr Thr Leu 
    530                 535                 540                 


Ile Leu Ile Leu Val Cys Ala Trp His Trp Arg Asn Arg Lys Lys Lys 
545                 550                 555                 560 


Thr Glu Gly Thr Tyr Asp Leu Pro Tyr Trp Asp Arg Ala Gly Trp Trp 
                565                 570                 575     


Lys Gly Met Lys Gln Phe Leu Pro Ala Lys Ala Val Asp His Glu Glu 
            580                 585                 590         


Thr Pro Val Arg Tyr Ser Ser Ser Glu Val Asn His Leu Ser Pro Arg 
        595                 600                 605             


Glu Val Thr Thr Val Leu Gln Ala Asp Ser Ala Glu Tyr Ala Gln Pro 
    610                 615                 620                 


Leu Val Gly Gly Ile Val Gly Thr Leu His Gln Arg Ser Thr Phe Lys 
625                 630                 635                 640 


Pro Glu Glu Gly Lys Glu Ala Gly Tyr Ala Asp Leu Asp Pro Tyr Asn 
                645                 650                 655     


Ser Pro Gly Gln Glu Val Tyr His Ala Tyr Ala Glu Pro Leu Pro Ile 
            660                 665                 670         


Thr Gly Pro Glu Tyr Ala Thr Pro Ile Ile Met Asp Met Ser Gly His 
        675                 680                 685             


Pro Thr Thr Ser Val Gly Gln Pro Ser Thr Ser Thr Phe Lys Ala Thr 
    690                 695                 700                 


Gly Asn Gln Pro Pro Pro Leu Val Gly Thr Tyr Asn Thr Leu Leu Ser 
705                 710                 715                 720 


Arg Thr Asp Ser Cys Ser Ser Ala Gln Ala Gln Tyr Asp Thr Pro Lys 
                725                 730                 735     


Ala Gly Lys Pro Gly Leu Pro Ala Pro Asp Glu Leu Val Tyr Gln Val 
            740                 745                 750         


Pro Gln Ser Thr Gln Glu Val Ser Gly Ala Gly Arg Asp Gly Glu Cys 
        755                 760                 765             


Asp Val Phe Lys Glu Ile Leu 
    770                 775 


<210>  169
<211>  1445
<212>  PRT
<213>  Homo sapiens

<400>  169

Met Arg Arg Leu Leu Glu Pro Cys Trp Trp Ile Leu Phe Leu Lys Ile 
1               5                   10                  15      


Thr Ser Ser Val Leu His Tyr Val Val Cys Phe Pro Ala Leu Thr Glu 
            20                  25                  30          


Gly Tyr Val Gly Ala Leu His Glu Asn Arg His Gly Ser Ala Val Gln 
        35                  40                  45              


Ile Arg Arg Arg Lys Ala Ser Gly Asp Pro Tyr Trp Ala Tyr Ser Gly 
    50                  55                  60                  


Ala Tyr Gly Pro Glu His Trp Val Thr Ser Ser Val Ser Cys Gly Gly 
65                  70                  75                  80  


Arg His Gln Ser Pro Ile Asp Ile Leu Asp Gln Tyr Ala Arg Val Gly 
                85                  90                  95      


Glu Glu Tyr Gln Glu Leu Gln Leu Asp Gly Phe Asp Asn Glu Ser Ser 
            100                 105                 110         


Asn Lys Thr Trp Met Lys Asn Thr Gly Lys Thr Val Ala Ile Leu Leu 
        115                 120                 125             


Lys Asp Asp Tyr Phe Val Ser Gly Ala Gly Leu Pro Gly Arg Phe Lys 
    130                 135                 140                 


Ala Glu Lys Val Glu Phe His Trp Gly His Ser Asn Gly Ser Ala Gly 
145                 150                 155                 160 


Ser Glu His Ser Ile Asn Gly Arg Arg Phe Pro Val Glu Met Gln Ile 
                165                 170                 175     


Phe Phe Tyr Asn Pro Asp Asp Phe Asp Ser Phe Gln Thr Ala Ile Ser 
            180                 185                 190         


Glu Asn Arg Ile Ile Gly Ala Met Ala Ile Phe Phe Gln Val Ser Pro 
        195                 200                 205             


Arg Asp Asn Ser Ala Leu Asp Pro Ile Ile His Gly Leu Lys Gly Val 
    210                 215                 220                 


Val His His Glu Lys Glu Thr Phe Leu Asp Pro Phe Val Leu Arg Asp 
225                 230                 235                 240 


Leu Leu Pro Ala Ser Leu Gly Ser Tyr Tyr Arg Tyr Thr Gly Ser Leu 
                245                 250                 255     


Thr Thr Pro Pro Cys Ser Glu Ile Val Glu Trp Ile Val Phe Arg Arg 
            260                 265                 270         


Pro Val Pro Ile Ser Tyr His Gln Leu Glu Ala Phe Tyr Ser Ile Phe 
        275                 280                 285             


Thr Thr Glu Gln Gln Asp His Val Lys Ser Val Glu Tyr Leu Arg Asn 
    290                 295                 300                 


Asn Phe Arg Pro Gln Gln Arg Leu His Asp Arg Val Val Ser Lys Ser 
305                 310                 315                 320 


Ala Val Arg Asp Ser Trp Asn His Asp Met Thr Asp Phe Leu Glu Asn 
                325                 330                 335     


Pro Leu Gly Thr Glu Ala Ser Lys Val Cys Ser Ser Pro Pro Ile His 
            340                 345                 350         


Met Lys Val Gln Pro Leu Asn Gln Thr Ala Leu Gln Val Ser Trp Ser 
        355                 360                 365             


Gln Pro Glu Thr Ile Tyr His Pro Pro Ile Met Asn Tyr Met Ile Ser 
    370                 375                 380                 


Tyr Ser Trp Thr Lys Asn Glu Asp Glu Lys Glu Lys Thr Phe Thr Lys 
385                 390                 395                 400 


Asp Ser Asp Lys Asp Leu Lys Ala Thr Ile Ser His Val Ser Pro Asp 
                405                 410                 415     


Ser Leu Tyr Leu Phe Arg Val Gln Ala Val Cys Arg Asn Asp Met Arg 
            420                 425                 430         


Ser Asp Phe Ser Gln Thr Met Leu Phe Gln Ala Asn Thr Thr Arg Ile 
        435                 440                 445             


Phe Gln Gly Thr Arg Ile Val Lys Thr Gly Val Pro Thr Ala Ser Pro 
    450                 455                 460                 


Ala Ser Ser Ala Asp Met Ala Pro Ile Ser Ser Gly Ser Ser Thr Trp 
465                 470                 475                 480 


Thr Ser Ser Gly Ile Pro Phe Ser Phe Val Ser Met Ala Thr Gly Met 
                485                 490                 495     


Gly Pro Ser Ser Ser Gly Ser Gln Ala Thr Val Ala Ser Val Val Thr 
            500                 505                 510         


Ser Thr Leu Leu Ala Gly Leu Gly Phe Gly Gly Gly Gly Ile Ser Ser 
        515                 520                 525             


Phe Pro Ser Thr Val Trp Pro Thr Arg Leu Pro Thr Ala Ala Ser Ala 
    530                 535                 540                 


Ser Lys Gln Ala Ala Arg Pro Val Leu Ala Thr Thr Glu Ala Leu Ala 
545                 550                 555                 560 


Ser Pro Gly Pro Asp Gly Asp Ser Ser Pro Thr Lys Asp Gly Glu Gly 
                565                 570                 575     


Thr Glu Glu Gly Glu Lys Asp Glu Lys Ser Glu Ser Glu Asp Gly Glu 
            580                 585                 590         


Arg Glu His Glu Glu Asp Gly Glu Lys Asp Ser Glu Lys Lys Glu Lys 
        595                 600                 605             


Ser Gly Val Thr His Ala Ala Glu Glu Arg Asn Gln Thr Glu Pro Ser 
    610                 615                 620                 


Pro Thr Pro Ser Ser Pro Asn Arg Thr Ala Glu Gly Gly His Gln Thr 
625                 630                 635                 640 


Ile Pro Gly His Glu Gln Asp His Thr Ala Val Pro Thr Asp Gln Thr 
                645                 650                 655     


Gly Gly Arg Arg Asp Ala Gly Pro Gly Leu Asp Pro Asp Met Val Thr 
            660                 665                 670         


Ser Thr Gln Val Pro Pro Thr Ala Thr Glu Glu Gln Tyr Ala Gly Ser 
        675                 680                 685             


Asp Pro Lys Arg Pro Glu Met Pro Ser Lys Lys Pro Met Ser Arg Gly 
    690                 695                 700                 


Asp Arg Phe Ser Glu Asp Ser Arg Phe Ile Thr Val Asn Pro Ala Glu 
705                 710                 715                 720 


Lys Asn Thr Ser Gly Met Ile Ser Arg Pro Ala Pro Gly Arg Met Glu 
                725                 730                 735     


Trp Ile Ile Pro Leu Ile Val Val Ser Ala Leu Thr Phe Val Cys Leu 
            740                 745                 750         


Ile Leu Leu Ile Ala Val Leu Val Tyr Trp Arg Gly Cys Asn Lys Ile 
        755                 760                 765             


Lys Ser Lys Gly Phe Pro Arg Arg Phe Arg Glu Val Pro Ser Ser Gly 
    770                 775                 780                 


Glu Arg Gly Glu Lys Gly Ser Arg Lys Cys Phe Gln Thr Ala His Phe 
785                 790                 795                 800 


Tyr Val Glu Asp Ser Ser Ser Pro Arg Val Val Pro Asn Glu Ser Ile 
                805                 810                 815     


Pro Ile Ile Pro Ile Pro Asp Asp Met Glu Ala Ile Pro Val Lys Gln 
            820                 825                 830         


Phe Val Lys His Ile Gly Glu Leu Tyr Ser Asn Asn Gln His Gly Phe 
        835                 840                 845             


Ser Glu Asp Phe Glu Glu Val Gln Arg Cys Thr Ala Asp Met Asn Ile 
    850                 855                 860                 


Thr Ala Glu His Ser Asn His Pro Glu Asn Lys His Lys Asn Arg Tyr 
865                 870                 875                 880 


Ile Asn Ile Leu Ala Tyr Asp His Ser Arg Val Lys Leu Arg Pro Leu 
                885                 890                 895     


Pro Gly Lys Asp Ser Lys His Ser Asp Tyr Ile Asn Ala Asn Tyr Val 
            900                 905                 910         


Asp Gly Tyr Asn Lys Ala Lys Ala Tyr Ile Ala Thr Gln Gly Pro Leu 
        915                 920                 925             


Lys Ser Thr Phe Glu Asp Phe Trp Arg Met Ile Trp Glu Gln Asn Thr 
    930                 935                 940                 


Gly Ile Ile Val Met Ile Thr Asn Leu Val Glu Lys Gly Arg Arg Lys 
945                 950                 955                 960 


Cys Asp Gln Tyr Trp Pro Thr Glu Asn Ser Glu Glu Tyr Gly Asn Ile 
                965                 970                 975     


Ile Val Thr Leu Lys Ser Thr Lys Ile His Ala Cys Tyr Thr Val Arg 
            980                 985                 990         


Arg Phe Ser Ile Arg Asn Thr Lys  Val Lys Lys Gly Gln  Lys Gly Asn 
        995                 1000                 1005             


Pro Lys  Gly Arg Gln Asn Glu  Arg Val Val Ile Gln  Tyr His Tyr 
    1010                 1015                 1020             


Thr Gln  Trp Pro Asp Met Gly  Val Pro Glu Tyr Ala  Leu Pro Val 
    1025                 1030                 1035             


Leu Thr  Phe Val Arg Arg Ser  Ser Ala Ala Arg Met  Pro Glu Thr 
    1040                 1045                 1050             


Gly Pro  Val Leu Val His Cys  Ser Ala Gly Val Gly  Arg Thr Gly 
    1055                 1060                 1065             


Thr Tyr  Ile Val Ile Asp Ser  Met Leu Gln Gln Ile  Lys Asp Lys 
    1070                 1075                 1080             


Ser Thr  Val Asn Val Leu Gly  Phe Leu Lys His Ile  Arg Thr Gln 
    1085                 1090                 1095             


Arg Asn  Tyr Leu Val Gln Thr  Glu Glu Gln Tyr Ile  Phe Ile His 
    1100                 1105                 1110             


Asp Ala  Leu Leu Glu Ala Ile  Leu Gly Lys Glu Thr  Glu Val Ser 
    1115                 1120                 1125             


Ser Asn  Gln Leu His Ser Tyr  Val Asn Ser Ile Leu  Ile Pro Gly 
    1130                 1135                 1140             


Val Gly  Gly Lys Thr Arg Leu  Glu Lys Gln Phe Lys  Leu Val Thr 
    1145                 1150                 1155             


Gln Cys  Asn Ala Lys Tyr Val  Glu Cys Phe Ser Ala  Gln Lys Glu 
    1160                 1165                 1170             


Cys Asn  Lys Glu Lys Asn Arg  Asn Ser Ser Val Val  Pro Ser Glu 
    1175                 1180                 1185             


Arg Ala  Arg Val Gly Leu Ala  Pro Leu Pro Gly Met  Lys Gly Thr 
    1190                 1195                 1200             


Asp Tyr  Ile Asn Ala Ser Tyr  Ile Met Gly Tyr Tyr  Arg Ser Asn 
    1205                 1210                 1215             


Glu Phe  Ile Ile Thr Gln His  Pro Leu Pro His Thr  Thr Lys Asp 
    1220                 1225                 1230             


Phe Trp  Arg Met Ile Trp Asp  His Asn Ala Gln Ile  Ile Val Met 
    1235                 1240                 1245             


Leu Pro  Asp Asn Gln Ser Leu  Ala Glu Asp Glu Phe  Val Tyr Trp 
    1250                 1255                 1260             


Pro Ser  Arg Glu Glu Ser Met  Asn Cys Glu Ala Phe  Thr Val Thr 
    1265                 1270                 1275             


Leu Ile  Ser Lys Asp Arg Leu  Cys Leu Ser Asn Glu  Glu Gln Ile 
    1280                 1285                 1290             


Ile Ile  His Asp Phe Ile Leu  Glu Ala Thr Gln Asp  Asp Tyr Val 
    1295                 1300                 1305             


Leu Glu  Val Arg His Phe Gln  Cys Pro Lys Trp Pro  Asn Pro Asp 
    1310                 1315                 1320             


Ala Pro  Ile Ser Ser Thr Phe  Glu Leu Ile Asn Val  Ile Lys Glu 
    1325                 1330                 1335             


Glu Ala  Leu Thr Arg Asp Gly  Pro Thr Ile Val His  Asp Glu Tyr 
    1340                 1345                 1350             


Gly Ala  Val Ser Ala Gly Met  Leu Cys Ala Leu Thr  Thr Leu Ser 
    1355                 1360                 1365             


Gln Gln  Leu Glu Asn Glu Asn  Ala Val Asp Val Phe  Gln Val Ala 
    1370                 1375                 1380             


Lys Met  Ile Asn Leu Met Arg  Pro Gly Val Phe Thr  Asp Ile Glu 
    1385                 1390                 1395             


Gln Tyr  Gln Phe Ile Tyr Lys  Ala Met Leu Ser Leu  Val Ser Thr 
    1400                 1405                 1410             


Lys Glu  Asn Gly Asn Gly Pro  Met Thr Val Asp Lys  Asn Gly Ala 
    1415                 1420                 1425             


Val Leu  Ile Ala Asp Glu Ser  Asp Pro Ala Glu Ser  Met Glu Ser 
    1430                 1435                 1440             


Leu Val  
    1445 


<210>  170
<211>  1310
<212>  PRT
<213>  Homo sapiens

<400>  170

Met Ala Gln Leu Trp Leu Ser Cys Phe Leu Leu Pro Ala Leu Val Val 
1               5                   10                  15      


Ser Val Ala Ala Asn Val Ala Pro Lys Phe Leu Ala Asn Met Thr Ser 
            20                  25                  30          


Val Ile Leu Pro Glu Asp Leu Pro Val Gly Ala Gln Ala Phe Trp Leu 
        35                  40                  45              


Val Ala Glu Asp Gln Asp Asn Asp Pro Leu Thr Tyr Gly Met Ser Gly 
    50                  55                  60                  


Pro Asn Ala Tyr Phe Phe Ala Val Thr Pro Lys Thr Gly Glu Val Lys 
65                  70                  75                  80  


Leu Ala Ser Ala Leu Asp Tyr Glu Thr Leu Tyr Thr Phe Lys Val Thr 
                85                  90                  95      


Ile Ser Val Ser Asp Pro Tyr Ile Gln Val Gln Arg Glu Met Leu Val 
            100                 105                 110         


Ile Val Glu Asp Arg Asn Asp Asn Ala Pro Val Phe Gln Asn Thr Ala 
        115                 120                 125             


Phe Ser Thr Ser Ile Asn Glu Thr Leu Pro Val Gly Ser Val Val Phe 
    130                 135                 140                 


Ser Val Leu Ala Val Asp Lys Asp Met Gly Ser Ala Gly Met Val Val 
145                 150                 155                 160 


Tyr Ser Ile Glu Lys Val Ile Pro Ser Thr Gly Asp Ser Glu His Leu 
                165                 170                 175     


Phe Arg Ile Leu Ala Asn Gly Ser Ile Val Leu Asn Gly Ser Leu Ser 
            180                 185                 190         


Tyr Asn Asn Lys Ser Ala Phe Tyr Gln Leu Glu Leu Lys Ala Cys Asp 
        195                 200                 205             


Leu Gly Gly Met Tyr His Asn Thr Phe Thr Ile Gln Cys Ser Leu Pro 
    210                 215                 220                 


Val Phe Leu Ser Ile Ser Val Val Asp Gln Pro Asp Leu Asp Pro Gln 
225                 230                 235                 240 


Phe Val Arg Glu Phe Tyr Ser Ala Ser Val Ala Glu Asp Ala Ala Lys 
                245                 250                 255     


Gly Thr Ser Val Leu Thr Val Glu Ala Val Asp Gly Asp Lys Gly Ile 
            260                 265                 270         


Asn Asp Pro Val Ile Tyr Ser Ile Ser Tyr Ser Thr Arg Pro Gly Trp 
        275                 280                 285             


Phe Asp Ile Gly Ala Asp Gly Val Ile Arg Val Asn Gly Ser Leu Asp 
    290                 295                 300                 


Arg Glu Gln Leu Leu Glu Ala Asp Glu Glu Val Gln Leu Gln Val Thr 
305                 310                 315                 320 


Ala Thr Glu Thr His Leu Asn Ile Tyr Gly Gln Glu Ala Lys Val Ser 
                325                 330                 335     


Ile Trp Val Thr Val Arg Val Met Asp Val Asn Asp His Lys Pro Glu 
            340                 345                 350         


Phe Tyr Asn Cys Ser Leu Pro Ala Cys Thr Phe Thr Pro Glu Glu Ala 
        355                 360                 365             


Gln Val Asn Phe Thr Gly Tyr Val Asp Glu His Ala Ser Pro Arg Ile 
    370                 375                 380                 


Pro Ile Asp Asp Leu Thr Met Val Val Tyr Asp Pro Asp Lys Gly Ser 
385                 390                 395                 400 


Asn Gly Thr Phe Leu Leu Ser Leu Gly Gly Pro Asp Ala Glu Ala Phe 
                405                 410                 415     


Ser Val Ser Pro Glu Arg Ala Val Gly Ser Ala Ser Val Gln Val Leu 
            420                 425                 430         


Val Arg Val Ser Ala Leu Val Asp Tyr Glu Arg Gln Thr Ala Met Ala 
        435                 440                 445             


Val Gln Val Val Ala Thr Asp Ser Val Ser Gln Asn Phe Ser Val Ala 
    450                 455                 460                 


Met Val Thr Ile His Leu Arg Asp Ile Asn Asp His Arg Pro Thr Phe 
465                 470                 475                 480 


Pro Gln Ser Leu Tyr Val Leu Thr Val Pro Glu His Ser Ala Thr Gly 
                485                 490                 495     


Ser Val Val Thr Asp Ser Ile His Ala Thr Asp Pro Asp Thr Gly Ala 
            500                 505                 510         


Trp Gly Gln Ile Thr Tyr Ser Leu Leu Pro Gly Asn Gly Ala Asp Leu 
        515                 520                 525             


Phe Gln Val Asp Pro Val Ser Gly Thr Val Thr Val Arg Asn Gly Glu 
    530                 535                 540                 


Leu Leu Asp Arg Glu Ser Gln Ala Val Tyr Tyr Leu Thr Leu Gln Ala 
545                 550                 555                 560 


Thr Asp Gly Gly Asn Leu Ser Ser Ser Thr Thr Leu Gln Ile His Leu 
                565                 570                 575     


Leu Asp Ile Asn Asp Asn Ala Pro Val Val Ser Gly Ser Tyr Asn Ile 
            580                 585                 590         


Phe Val Gln Glu Glu Glu Gly Asn Val Ser Val Thr Ile Gln Ala His 
        595                 600                 605             


Asp Asn Asp Glu Pro Gly Thr Asn Asn Ser Arg Leu Leu Phe Asn Leu 
    610                 615                 620                 


Leu Pro Gly Pro Tyr Ser His Asn Phe Ser Leu Asp Pro Asp Thr Gly 
625                 630                 635                 640 


Leu Leu Arg Asn Leu Gly Pro Leu Asp Arg Glu Ala Ile Asp Pro Ala 
                645                 650                 655     


Leu Glu Gly Arg Ile Val Leu Thr Val Leu Val Ser Asp Cys Gly Glu 
            660                 665                 670         


Pro Val Leu Gly Thr Lys Val Asn Val Thr Ile Thr Val Glu Asp Ile 
        675                 680                 685             


Asn Asp Asn Leu Pro Ile Phe Asn Gln Ser Ser Tyr Asn Phe Thr Val 
    690                 695                 700                 


Lys Glu Glu Asp Pro Gly Val Leu Val Gly Val Val Lys Ala Trp Asp 
705                 710                 715                 720 


Ala Asp Gln Thr Glu Ala Asn Asn Arg Ile Ser Phe Ser Leu Ser Gly 
                725                 730                 735     


Ser Gly Ala Asn Tyr Phe Met Ile Arg Gly Leu Val Leu Gly Ala Gly 
            740                 745                 750         


Trp Ala Glu Gly Tyr Leu Arg Leu Pro Pro Asp Val Ser Leu Asp Tyr 
        755                 760                 765             


Glu Thr Gln Pro Val Phe Asn Leu Thr Val Ser Ala Glu Asn Pro Asp 
    770                 775                 780                 


Pro Gln Gly Gly Glu Thr Ile Val Asp Val Cys Val Asn Val Lys Asp 
785                 790                 795                 800 


Val Asn Asp Asn Pro Pro Thr Leu Asp Val Ala Ser Leu Arg Gly Ile 
                805                 810                 815     


Arg Val Ala Glu Asn Gly Ser Gln His Gly Gln Val Ala Val Val Val 
            820                 825                 830         


Ala Ser Asp Val Asp Thr Ser Ala Gln Leu Glu Ile Gln Leu Val Asn 
        835                 840                 845             


Ile Leu Cys Thr Lys Ala Gly Val Asp Val Gly Ser Leu Cys Trp Gly 
    850                 855                 860                 


Trp Phe Ser Val Ala Ala Asn Gly Ser Val Tyr Ile Asn Gln Ser Lys 
865                 870                 875                 880 


Ala Ile Asp Tyr Glu Ala Cys Asp Leu Val Thr Leu Val Val Arg Ala 
                885                 890                 895     


Cys Asp Leu Ala Thr Asp Pro Gly Phe Gln Ala Tyr Ser Asn Asn Gly 
            900                 905                 910         


Ser Leu Leu Ile Thr Ile Glu Asp Val Asn Asp Asn Ala Pro Tyr Phe 
        915                 920                 925             


Leu Pro Glu Asn Lys Thr Phe Val Ile Ile Pro Glu Leu Val Leu Pro 
    930                 935                 940                 


Asn Arg Glu Val Ala Ser Val Arg Ala Arg Asp Asp Asp Ser Gly Asn 
945                 950                 955                 960 


Asn Gly Val Ile Leu Phe Ser Ile Leu Arg Val Asp Phe Ile Ser Lys 
                965                 970                 975     


Asp Gly Ala Thr Ile Pro Phe Gln Gly Val Phe Ser Ile Phe Thr Ser 
            980                 985                 990         


Ser Glu Ala Asp Val Phe Ala Gly  Ser Ile Gln Pro Val  Thr Ser Leu 
        995                 1000                 1005             


Asp Ser  Thr Leu Gln Gly Thr  Tyr Gln Val Thr Val  Gln Ala Arg 
    1010                 1015                 1020             


Asp Arg  Pro Ser Leu Gly Pro  Phe Leu Glu Ala Thr  Thr Thr Leu 
    1025                 1030                 1035             


Asn Leu  Phe Thr Val Asp Gln  Ser Tyr Arg Ser Arg  Leu Gln Phe 
    1040                 1045                 1050             


Ser Thr  Pro Lys Glu Glu Val  Gly Ala Asn Arg Gln  Ala Ile Asn 
    1055                 1060                 1065             


Ala Ala  Leu Thr Gln Ala Thr  Arg Thr Thr Val Tyr  Ile Val Asp 
    1070                 1075                 1080             


Ile Gln  Asp Ile Asp Ser Ala  Ala Arg Ala Arg Pro  His Ser Tyr 
    1085                 1090                 1095             


Leu Asp  Ala Tyr Phe Val Phe  Pro Asn Gly Ser Ala  Leu Thr Leu 
    1100                 1105                 1110             


Asp Glu  Leu Ser Val Met Ile  Arg Asn Asp Gln Asp  Ser Leu Thr 
    1115                 1120                 1125             


Gln Leu  Leu Gln Leu Gly Leu  Val Val Leu Gly Ser  Gln Glu Ser 
    1130                 1135                 1140             


Gln Glu  Ser Asp Leu Ser Lys  Gln Leu Ile Ser Val  Ile Ile Gly 
    1145                 1150                 1155             


Leu Gly  Val Ala Leu Leu Leu  Val Leu Val Ile Met  Thr Met Ala 
    1160                 1165                 1170             


Phe Val  Cys Val Arg Lys Ser  Tyr Asn Arg Lys Leu  Gln Ala Met 
    1175                 1180                 1185             


Lys Ala  Ala Lys Glu Ala Arg  Lys Thr Ala Ala Gly  Val Met Pro 
    1190                 1195                 1200             


Ser Ala  Pro Ala Ile Pro Gly  Thr Asn Met Tyr Asn  Thr Glu Arg 
    1205                 1210                 1215             


Ala Asn  Pro Met Leu Asn Leu  Pro Asn Lys Asp Leu  Gly Leu Glu 
    1220                 1225                 1230             


Tyr Leu  Ser Pro Ser Asn Asp  Leu Asp Ser Val Ser  Val Asn Ser 
    1235                 1240                 1245             


Leu Asp  Asp Asn Ser Val Asp  Val Asp Lys Asn Ser  Gln Glu Ile 
    1250                 1255                 1260             


Lys Glu  His Arg Pro Pro His  Thr Pro Pro Glu Pro  Asp Pro Glu 
    1265                 1270                 1275             


Pro Leu  Ser Val Val Leu Leu  Gly Arg Gln Ala Gly  Ala Ser Gly 
    1280                 1285                 1290             


Gln Leu  Glu Gly Pro Ser Tyr  Thr Asn Ala Gly Leu  Asp Thr Thr 
    1295                 1300                 1305             


Asp Leu  
    1310 


<210>  171
<211>  146
<212>  PRT
<213>  Homo sapiens

<400>  171

Met Ser Ala Glu Ser Gly Pro Gly Thr Arg Leu Arg Asn Leu Pro Val 
1               5                   10                  15      


Met Gly Asp Gly Leu Glu Thr Ser Gln Met Ser Thr Thr Gln Ala Gln 
            20                  25                  30          


Ala Gln Pro Gln Pro Ala Asn Ala Ala Ser Thr Asn Pro Pro Pro Pro 
        35                  40                  45              


Glu Thr Ser Asn Pro Asn Lys Pro Lys Arg Gln Thr Asn Gln Leu Gln 
    50                  55                  60                  


Tyr Leu Leu Arg Val Val Leu Lys Thr Leu Trp Lys His Gln Phe Ala 
65                  70                  75                  80  


Trp Pro Phe Gln Gln Pro Val Asp Ala Val Lys Leu Asn Leu Pro Asp 
                85                  90                  95      


Tyr Tyr Lys Ile Ile Lys Thr Pro Met Asp Met Gly Thr Ile Lys Lys 
            100                 105                 110         


Arg Leu Glu Asn Asn Tyr Tyr Trp Asn Ala Gln Glu Cys Ile Gln Asp 
        115                 120                 125             


Phe Asn Thr Met Phe Thr Asn Cys Tyr Ile Tyr Asn Lys Phe Arg Pro 
    130                 135                 140                 


Gln Met 
145     


<210>  172
<211>  2472
<212>  PRT
<213>  Homo sapiens

<400>  172

Met Asp Pro Ser Gly Val Lys Val Leu Glu Thr Ala Glu Asp Ile Gln 
1               5                   10                  15      


Glu Arg Arg Gln Gln Val Leu Asp Arg Tyr His Arg Phe Lys Glu Leu 
            20                  25                  30          


Ser Thr Leu Arg Arg Gln Lys Leu Glu Asp Ser Tyr Arg Phe Gln Phe 
        35                  40                  45              


Phe Gln Arg Asp Ala Glu Glu Leu Glu Lys Trp Ile Gln Glu Lys Leu 
    50                  55                  60                  


Gln Ile Ala Ser Asp Glu Asn Tyr Lys Asp Pro Thr Asn Leu Gln Gly 
65                  70                  75                  80  


Lys Leu Gln Lys His Gln Ala Phe Glu Ala Glu Val Gln Ala Asn Ser 
                85                  90                  95      


Gly Ala Ile Val Lys Leu Asp Glu Thr Gly Asn Leu Met Ile Ser Glu 
            100                 105                 110         


Gly His Phe Ala Ser Glu Thr Ile Arg Thr Arg Leu Met Glu Leu His 
        115                 120                 125             


Arg Gln Trp Glu Leu Leu Leu Glu Lys Met Arg Glu Lys Gly Ile Lys 
    130                 135                 140                 


Leu Leu Gln Ala Gln Lys Leu Val Gln Tyr Leu Arg Glu Cys Glu Asp 
145                 150                 155                 160 


Val Met Asp Trp Ile Asn Asp Lys Glu Ala Ile Val Thr Ser Glu Glu 
                165                 170                 175     


Leu Gly Gln Asp Leu Glu His Val Glu Val Leu Gln Lys Lys Phe Glu 
            180                 185                 190         


Glu Phe Gln Thr Asp Met Ala Ala His Glu Glu Arg Val Asn Glu Val 
        195                 200                 205             


Asn Gln Phe Ala Ala Lys Leu Ile Gln Glu Gln His Pro Glu Glu Glu 
    210                 215                 220                 


Leu Ile Lys Thr Lys Gln Asp Glu Val Asn Ala Ala Trp Gln Arg Leu 
225                 230                 235                 240 


Lys Gly Leu Ala Leu Gln Arg Gln Gly Lys Leu Phe Gly Ala Ala Glu 
                245                 250                 255     


Val Gln Arg Phe Asn Arg Asp Val Asp Glu Thr Ile Ser Trp Ile Lys 
            260                 265                 270         


Glu Lys Glu Gln Leu Met Ala Ser Asp Asp Phe Gly Arg Asp Leu Ala 
        275                 280                 285             


Ser Val Gln Ala Leu Leu Arg Lys His Glu Gly Leu Glu Arg Asp Leu 
    290                 295                 300                 


Ala Ala Leu Glu Asp Lys Val Lys Ala Leu Cys Ala Glu Ala Asp Arg 
305                 310                 315                 320 


Leu Gln Gln Ser His Pro Leu Ser Ala Thr Gln Ile Gln Val Lys Arg 
                325                 330                 335     


Glu Glu Leu Ile Thr Asn Trp Glu Gln Ile Arg Thr Leu Ala Ala Glu 
            340                 345                 350         


Arg His Ala Arg Leu Asn Asp Ser Tyr Arg Leu Gln Arg Phe Leu Ala 
        355                 360                 365             


Asp Phe Arg Asp Leu Thr Ser Trp Val Thr Glu Met Lys Ala Leu Ile 
    370                 375                 380                 


Asn Ala Asp Glu Leu Ala Ser Asp Val Ala Gly Ala Glu Ala Leu Leu 
385                 390                 395                 400 


Asp Arg His Gln Glu His Lys Gly Glu Ile Asp Ala His Glu Asp Ser 
                405                 410                 415     


Phe Lys Ser Ala Asp Glu Ser Gly Gln Ala Leu Leu Ala Ala Gly His 
            420                 425                 430         


Tyr Ala Ser Asp Glu Val Arg Glu Lys Leu Thr Val Leu Ser Glu Glu 
        435                 440                 445             


Arg Ala Ala Leu Leu Glu Leu Trp Glu Leu Arg Arg Gln Gln Tyr Glu 
    450                 455                 460                 


Gln Cys Met Asp Leu Gln Leu Phe Tyr Arg Asp Thr Glu Gln Val Asp 
465                 470                 475                 480 


Asn Trp Met Ser Lys Gln Glu Ala Phe Leu Leu Asn Glu Asp Leu Gly 
                485                 490                 495     


Asp Ser Leu Asp Ser Val Glu Ala Leu Leu Lys Lys His Glu Asp Phe 
            500                 505                 510         


Glu Lys Ser Leu Ser Ala Gln Glu Glu Lys Ile Thr Ala Leu Asp Glu 
        515                 520                 525             


Phe Ala Thr Lys Leu Ile Gln Asn Asn His Tyr Ala Met Glu Asp Val 
    530                 535                 540                 


Ala Thr Arg Arg Asp Ala Leu Leu Ser Arg Arg Asn Ala Leu His Glu 
545                 550                 555                 560 


Arg Ala Met Arg Arg Arg Ala Gln Leu Ala Asp Ser Phe His Leu Gln 
                565                 570                 575     


Gln Phe Phe Arg Asp Ser Asp Glu Leu Lys Ser Trp Val Asn Glu Lys 
            580                 585                 590         


Met Lys Thr Ala Thr Asp Glu Ala Tyr Lys Asp Pro Ser Asn Leu Gln 
        595                 600                 605             


Gly Lys Val Gln Lys His Gln Ala Phe Glu Ala Glu Leu Ser Ala Asn 
    610                 615                 620                 


Gln Ser Arg Ile Asp Ala Leu Glu Lys Ala Gly Gln Lys Leu Ile Asp 
625                 630                 635                 640 


Val Asn His Tyr Ala Lys Asp Glu Val Ala Ala Arg Met Asn Glu Val 
                645                 650                 655     


Ile Ser Leu Trp Lys Lys Leu Leu Glu Ala Thr Glu Leu Lys Gly Ile 
            660                 665                 670         


Lys Leu Arg Glu Ala Asn Gln Gln Gln Gln Phe Asn Arg Asn Val Glu 
        675                 680                 685             


Asp Ile Glu Leu Trp Leu Tyr Glu Val Glu Gly His Leu Ala Ser Asp 
    690                 695                 700                 


Asp Tyr Gly Lys Asp Leu Thr Asn Val Gln Asn Leu Gln Lys Lys His 
705                 710                 715                 720 


Ala Leu Leu Glu Ala Asp Val Ala Ala His Gln Asp Arg Ile Asp Gly 
                725                 730                 735     


Ile Thr Ile Gln Ala Arg Gln Phe Gln Asp Ala Gly His Phe Asp Ala 
            740                 745                 750         


Glu Asn Ile Lys Lys Lys Gln Glu Ala Leu Val Ala Arg Tyr Glu Ala 
        755                 760                 765             


Leu Lys Glu Pro Met Val Ala Arg Lys Gln Lys Leu Ala Asp Ser Leu 
    770                 775                 780                 


Arg Leu Gln Gln Leu Phe Arg Asp Val Glu Asp Glu Glu Thr Trp Ile 
785                 790                 795                 800 


Arg Glu Lys Glu Pro Ile Ala Ala Ser Thr Asn Arg Gly Lys Asp Leu 
                805                 810                 815     


Ile Gly Val Gln Asn Leu Leu Lys Lys His Gln Ala Leu Gln Ala Glu 
            820                 825                 830         


Ile Ala Gly His Glu Pro Arg Ile Lys Ala Val Thr Gln Lys Gly Asn 
        835                 840                 845             


Ala Met Val Glu Glu Gly His Phe Ala Ala Glu Asp Val Lys Ala Lys 
    850                 855                 860                 


Leu His Glu Leu Asn Gln Lys Trp Glu Ala Leu Lys Ala Lys Ala Ser 
865                 870                 875                 880 


Gln Arg Arg Gln Asp Leu Glu Asp Ser Leu Gln Ala Gln Gln Tyr Phe 
                885                 890                 895     


Ala Asp Ala Asn Glu Ala Glu Ser Trp Met Arg Glu Lys Glu Pro Ile 
            900                 905                 910         


Val Gly Ser Thr Asp Tyr Gly Lys Asp Glu Asp Ser Ala Glu Ala Leu 
        915                 920                 925             


Leu Lys Lys His Glu Ala Leu Met Ser Asp Leu Ser Ala Tyr Gly Ser 
    930                 935                 940                 


Ser Ile Gln Ala Leu Arg Glu Gln Ala Gln Ser Cys Arg Gln Gln Val 
945                 950                 955                 960 


Ala Pro Thr Asp Asp Glu Thr Gly Lys Glu Leu Val Leu Ala Leu Tyr 
                965                 970                 975     


Asp Tyr Gln Glu Lys Ser Pro Arg Glu Val Thr Met Lys Lys Gly Asp 
            980                 985                 990         


Ile Leu Thr Leu Leu Asn Ser Thr  Asn Lys Asp Trp Trp  Lys Val Glu 
        995                 1000                 1005             


Val Asn  Asp Arg Gln Gly Phe  Val Pro Ala Ala Tyr  Val Lys Lys 
    1010                 1015                 1020             


Leu Asp  Pro Ala Gln Ser Ala  Ser Arg Glu Asn Leu  Leu Glu Glu 
    1025                 1030                 1035             


Gln Gly  Ser Ile Ala Leu Arg  Gln Glu Gln Ile Asp  Asn Gln Thr 
    1040                 1045                 1050             


Arg Ile  Thr Lys Glu Ala Gly  Ser Val Ser Leu Arg  Met Lys Gln 
    1055                 1060                 1065             


Val Glu  Glu Leu Tyr His Ser  Leu Leu Glu Leu Gly  Glu Lys Arg 
    1070                 1075                 1080             


Lys Gly  Met Leu Glu Lys Ser  Cys Lys Lys Phe Met  Leu Phe Arg 
    1085                 1090                 1095             


Glu Ala  Asn Glu Leu Gln Gln  Trp Ile Asn Glu Lys  Glu Ala Ala 
    1100                 1105                 1110             


Leu Thr  Ser Glu Glu Val Gly  Ala Asp Leu Glu Gln  Val Glu Val 
    1115                 1120                 1125             


Leu Gln  Lys Lys Phe Asp Asp  Phe Gln Lys Asp Leu  Lys Ala Asn 
    1130                 1135                 1140             


Glu Ser  Arg Leu Lys Asp Ile  Asn Lys Val Ala Glu  Asp Leu Glu 
    1145                 1150                 1155             


Ser Glu  Gly Leu Met Ala Glu  Glu Val Gln Ala Val  Gln Gln Gln 
    1160                 1165                 1170             


Glu Val  Tyr Gly Met Met Pro  Arg Asp Glu Thr Asp  Ser Lys Thr 
    1175                 1180                 1185             


Ala Ser  Pro Trp Lys Ser Ala  Arg Leu Met Val His  Thr Val Ala 
    1190                 1195                 1200             


Thr Phe  Asn Ser Ile Lys Glu  Leu Asn Glu Arg Trp  Arg Ser Leu 
    1205                 1210                 1215             


Gln Gln  Leu Ala Glu Glu Arg  Ser Gln Leu Leu Gly  Ser Ala His 
    1220                 1225                 1230             


Glu Val  Gln Arg Phe His Arg  Asp Ala Asp Glu Thr  Lys Glu Trp 
    1235                 1240                 1245             


Ile Glu  Glu Lys Asn Gln Ala  Leu Asn Thr Asp Asn  Tyr Gly His 
    1250                 1255                 1260             


Asp Leu  Ala Ser Val Gln Ala  Leu Gln Arg Lys His  Glu Gly Phe 
    1265                 1270                 1275             


Glu Arg  Asp Leu Ala Ala Leu  Gly Asp Lys Val Asn  Ser Leu Gly 
    1280                 1285                 1290             


Glu Thr  Ala Glu Arg Leu Ile  Gln Ser His Pro Glu  Ser Ala Glu 
    1295                 1300                 1305             


Asp Leu  Gln Glu Lys Cys Thr  Glu Leu Asn Gln Ala  Trp Ser Ser 
    1310                 1315                 1320             


Leu Gly  Lys Arg Ala Asp Gln  Arg Lys Ala Lys Leu  Gly Asp Ser 
    1325                 1330                 1335             


His Asp  Leu Gln Arg Phe Leu  Ser Asp Phe Arg Asp  Leu Met Ser 
    1340                 1345                 1350             


Trp Ile  Asn Gly Ile Arg Gly  Leu Val Ser Ser Asp  Glu Leu Ala 
    1355                 1360                 1365             


Lys Asp  Val Thr Gly Ala Glu  Ala Leu Leu Glu Arg  His Gln Glu 
    1370                 1375                 1380             


His Arg  Thr Glu Ile Asp Ala  Arg Ala Gly Thr Phe  Gln Ala Phe 
    1385                 1390                 1395             


Glu Gln  Phe Gly Gln Gln Leu  Leu Ala His Gly His  Tyr Ala Ser 
    1400                 1405                 1410             


Pro Glu  Ile Lys Gln Lys Leu  Asp Ile Leu Asp Gln  Glu Arg Ala 
    1415                 1420                 1425             


Asp Leu  Glu Lys Ala Trp Val  Gln Arg Arg Met Met  Leu Asp Gln 
    1430                 1435                 1440             


Cys Leu  Glu Leu Gln Leu Phe  His Arg Asp Cys Glu  Gln Ala Glu 
    1445                 1450                 1455             


Asn Trp  Met Ala Ala Arg Glu  Ala Phe Leu Asn Thr  Glu Asp Lys 
    1460                 1465                 1470             


Gly Asp  Ser Leu Asp Ser Val  Glu Ala Leu Ile Lys  Lys His Glu 
    1475                 1480                 1485             


Asp Phe  Asp Lys Ala Ile Asn  Val Gln Glu Glu Lys  Ile Ala Ala 
    1490                 1495                 1500             


Leu Gln  Ala Phe Ala Asp Gln  Leu Ile Ala Ala Gly  His Tyr Ala 
    1505                 1510                 1515             


Lys Gly  Asp Ile Ser Ser Arg  Arg Asn Glu Val Leu  Asp Arg Trp 
    1520                 1525                 1530             


Arg Arg  Leu Lys Ala Gln Met  Ile Glu Lys Arg Ser  Lys Leu Gly 
    1535                 1540                 1545             


Glu Ser  Gln Thr Leu Gln Gln  Phe Ser Arg Asp Val  Asp Glu Ile 
    1550                 1555                 1560             


Glu Ala  Trp Ile Ser Glu Lys  Leu Gln Thr Ala Ser  Asp Glu Ser 
    1565                 1570                 1575             


Tyr Lys  Asp Pro Thr Asn Ile  Gln Ser Lys His Gln  Lys His Gln 
    1580                 1585                 1590             


Ala Phe  Glu Ala Glu Leu His  Ala Asn Ala Asp Arg  Ile Arg Gly 
    1595                 1600                 1605             


Val Ile  Asp Met Gly Asn Ser  Leu Ile Glu Arg Gly  Ala Cys Ala 
    1610                 1615                 1620             


Gly Ser  Glu Asp Ala Val Lys  Ala Arg Leu Ala Ala  Leu Ala Asp 
    1625                 1630                 1635             


Gln Trp  Gln Phe Leu Val Gln  Lys Ser Ala Glu Lys  Ser Gln Lys 
    1640                 1645                 1650             


Leu Lys  Glu Ala Asn Lys Gln  Gln Asn Phe Asn Thr  Gly Ile Lys 
    1655                 1660                 1665             


Asp Phe  Asp Phe Trp Leu Ser  Glu Val Glu Ala Leu  Leu Ala Ser 
    1670                 1675                 1680             


Glu Asp  Tyr Gly Lys Asp Leu  Ala Ser Val Asn Asn  Leu Leu Lys 
    1685                 1690                 1695             


Lys His  Gln Leu Leu Glu Ala  Asp Ile Ser Ala His  Glu Asp Arg 
    1700                 1705                 1710             


Leu Lys  Asp Leu Asn Ser Gln  Ala Asp Ser Leu Met  Thr Ser Ser 
    1715                 1720                 1725             


Ala Phe  Asp Thr Ser Gln Val  Lys Asp Lys Arg Asp  Thr Ile Asn 
    1730                 1735                 1740             


Gly Arg  Phe Gln Lys Ile Lys  Ser Met Ala Ala Ser  Arg Arg Ala 
    1745                 1750                 1755             


Lys Leu  Asn Glu Ser His Arg  Leu His Gln Phe Phe  Arg Asp Met 
    1760                 1765                 1770             


Asp Asp  Glu Glu Ser Trp Ile  Lys Glu Lys Lys Leu  Leu Val Gly 
    1775                 1780                 1785             


Ser Glu  Asp Tyr Gly Arg Asp  Leu Thr Gly Val Gln  Asn Leu Arg 
    1790                 1795                 1800             


Lys Lys  His Lys Arg Leu Glu  Ala Glu Leu Ala Ala  His Glu Pro 
    1805                 1810                 1815             


Ala Ile  Gln Gly Val Leu Asp  Thr Gly Lys Lys Leu  Ser Asp Asp 
    1820                 1825                 1830             


Asn Thr  Ile Gly Lys Glu Glu  Ile Gln Gln Arg Leu  Ala Gln Phe 
    1835                 1840                 1845             


Val Glu  His Trp Lys Glu Leu  Lys Gln Leu Ala Ala  Ala Arg Gly 
    1850                 1855                 1860             


Gln Arg  Leu Glu Glu Ser Leu  Glu Tyr Gln Gln Phe  Val Ala Asn 
    1865                 1870                 1875             


Val Glu  Glu Glu Glu Ala Trp  Ile Asn Glu Lys Met  Thr Leu Val 
    1880                 1885                 1890             


Ala Ser  Glu Asp Tyr Gly Asp  Thr Leu Ala Ala Ile  Gln Gly Leu 
    1895                 1900                 1905             


Leu Lys  Lys His Glu Ala Phe  Glu Thr Asp Phe Thr  Val His Lys 
    1910                 1915                 1920             


Asp Arg  Val Asn Asp Val Cys  Thr Asn Gly Gln Asp  Leu Ile Lys 
    1925                 1930                 1935             


Lys Asn  Asn His His Glu Glu  Asn Ile Ser Ser Lys  Met Lys Gly 
    1940                 1945                 1950             


Leu Asn  Gly Lys Val Ser Asp  Leu Glu Lys Ala Ala  Ala Gln Arg 
    1955                 1960                 1965             


Lys Ala  Lys Leu Asp Glu Asn  Ser Ala Phe Leu Gln  Phe Asn Trp 
    1970                 1975                 1980             


Lys Ala  Asp Val Val Glu Ser  Trp Ile Gly Glu Lys  Glu Asn Ser 
    1985                 1990                 1995             


Leu Lys  Thr Asp Asp Tyr Gly  Arg Asp Leu Ser Ser  Val Gln Thr 
    2000                 2005                 2010             


Leu Leu  Thr Lys Gln Glu Thr  Phe Asp Ala Gly Leu  Gln Ala Phe 
    2015                 2020                 2025             


Gln Gln  Glu Gly Ile Ala Asn  Ile Thr Ala Leu Lys  Asp Gln Leu 
    2030                 2035                 2040             


Leu Ala  Ala Lys His Val Gln  Ser Lys Ala Ile Glu  Ala Arg His 
    2045                 2050                 2055             


Ala Ser  Leu Met Lys Arg Trp  Ser Gln Leu Leu Ala  Asn Ser Ala 
    2060                 2065                 2070             


Ala Arg  Lys Lys Lys Leu Leu  Glu Ala Gln Ser His  Phe Arg Lys 
    2075                 2080                 2085             


Val Glu  Asp Leu Phe Leu Thr  Phe Ala Lys Lys Ala  Ser Ala Phe 
    2090                 2095                 2100             


Asn Ser  Trp Phe Glu Asn Ala  Glu Glu Asp Leu Thr  Asp Pro Val 
    2105                 2110                 2115             


Arg Cys  Asn Ser Leu Glu Glu  Ile Lys Ala Leu Arg  Glu Ala His 
    2120                 2125                 2130             


Asp Ala  Phe Arg Ser Ser Leu  Ser Ser Ala Gln Ala  Asp Phe Asn 
    2135                 2140                 2145             


Gln Leu  Ala Glu Leu Asp Arg  Gln Ile Lys Ser Phe  Arg Val Ala 
    2150                 2155                 2160             


Ser Asn  Pro Tyr Thr Trp Phe  Thr Met Glu Ala Leu  Glu Glu Thr 
    2165                 2170                 2175             


Trp Arg  Asn Leu Gln Lys Ile  Ile Lys Glu Arg Glu  Leu Glu Leu 
    2180                 2185                 2190             


Gln Lys  Glu Gln Arg Arg Gln  Glu Glu Asn Asp Lys  Leu Arg Gln 
    2195                 2200                 2205             


Glu Phe  Ala Gln His Ala Asn  Ala Phe His Gln Trp  Ile Gln Glu 
    2210                 2215                 2220             


Thr Arg  Thr Tyr Leu Leu Asp  Gly Ser Cys Met Val  Glu Glu Ser 
    2225                 2230                 2235             


Gly Thr  Leu Glu Ser Gln Leu  Glu Ala Thr Lys Arg  Lys His Gln 
    2240                 2245                 2250             


Glu Ile  Arg Ala Met Arg Ser  Gln Leu Lys Lys Ile  Glu Asp Leu 
    2255                 2260                 2265             


Gly Ala  Ala Met Glu Glu Ala  Leu Ile Leu Asp Asn  Lys Tyr Thr 
    2270                 2275                 2280             


Glu His  Ser Thr Val Gly Leu  Ala Gln Gln Trp Asp  Gln Leu Asp 
    2285                 2290                 2295             


Gln Leu  Gly Met Arg Met Gln  His Asn Leu Glu Gln  Gln Ile Gln 
    2300                 2305                 2310             


Ala Arg  Asn Thr Thr Gly Val  Thr Glu Glu Ala Leu  Lys Glu Phe 
    2315                 2320                 2325             


Ser Met  Met Phe Lys His Phe  Asp Lys Asp Lys Ser  Gly Arg Leu 
    2330                 2335                 2340             


Asn His  Gln Glu Phe Lys Ser  Cys Leu Arg Ser Leu  Gly Tyr Asp 
    2345                 2350                 2355             


Leu Pro  Met Val Glu Glu Gly  Glu Pro Asp Pro Glu  Phe Glu Ala 
    2360                 2365                 2370             


Ile Leu  Asp Thr Val Asp Pro  Asn Arg Asp Gly His  Val Ser Leu 
    2375                 2380                 2385             


Gln Glu  Tyr Met Ala Phe Met  Ile Ser Arg Glu Thr  Glu Asn Val 
    2390                 2395                 2400             


Lys Ser  Ser Glu Glu Ile Glu  Ser Ala Phe Arg Ala  Leu Ser Ser 
    2405                 2410                 2415             


Glu Gly  Lys Pro Tyr Val Thr  Lys Glu Glu Leu Tyr  Gln Asn Leu 
    2420                 2425                 2430             


Thr Arg  Glu Gln Ala Asp Tyr  Cys Val Ser His Met  Lys Pro Tyr 
    2435                 2440                 2445             


Val Asp  Gly Lys Gly Arg Glu  Leu Pro Thr Ala Phe  Asp Tyr Val 
    2450                 2455                 2460             


Glu Phe  Thr Arg Ser Leu Phe  Val Asn 
    2465                 2470         


