                         SEQUENCE LISTING 

<110>  RINAT NEUROSCIENCE CORP.
 
<120>  Methods for Treating Visceral Pain by Administering Antagonist Antibodies Directed Against Calcitonin Gene-Related Peptide

<130>  PC33920A

<150>  US 61/237,901 
<151>  2009-08-28

<160>  39    

<170>  PatentIn version 3.5

<210>  1
<211>  122
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide, Antibody G1 heavy chain variable region

<400>  1

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Glu Ser Asp Ala Ser Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Leu Ala Tyr Phe Asp Tyr Gly Leu Ala Ile Gln Asn Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120         


<210>  2
<211>  107
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide, Antibody G1 light chain variable region

<400>  2

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Lys Arg Val Thr Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Leu Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Ser Gln Ser Tyr Asn Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys 
            100                 105         


<210>  3
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide, Antibody G1 CDR H1 

<400>  3

Gly Phe Thr Phe Ser Asn Tyr Trp Ile Ser 
1               5                   10  


<210>  4
<211>  19
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide, Antibody G1 CDR H2

<400>  4

Glu Ile Arg Ser Glu Ser Asp Ala Ser Ala Thr His Tyr Ala Glu Ala 
1               5                   10                  15      


Val Lys Gly 
            


<210>  5
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide, Antibody G1 CDR H3

<400>  5

Tyr Phe Asp Tyr Gly Leu Ala Ile Gln Asn Tyr 
1               5                   10      


<210>  6
<211>  11
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide, Antibody G1 CDR L1 

<400>  6

Lys Ala Ser Lys Arg Val Thr Thr Tyr Val Ser 
1               5                   10      


<210>  7
<211>  7
<212>  PRT
<213>  Artificial sequence 

<220>
<223>  Synthetic polypeptide, Antibody G1 CDR L2 

<400>  7

Gly Ala Ser Asn Arg Tyr Leu 
1               5           


<210>  8
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide, Antibody G1 CDR L3

<400>  8

Ser Gln Ser Tyr Asn Tyr Pro Tyr Thr 
1               5                   


<210>  9
<211>  366
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide, Antibody G1 heavy chain variable region 

<400>  9

gaagttcagc tggttgaatc cggtggtggt ctggttcagc caggtggttc cctgcgtctg     60

tcctgcgctg cttccggttt caccttctcc aactactgga tctcctgggt tcgtcaggct    120

cctggtaaag gtctggaatg ggttgctgaa atccgttccg aatccgacgc gtccgctacc    180

cattacgctg aagctgttaa aggtcgtttc accatctccc gtgacaacgc taagaactcc    240

ctgtacctgc agatgaactc cctgcgtgct gaagacaccg ctgtttacta ctgcctggct    300

tactttgact acggtctggc tatccagaac tactggggtc agggtaccct ggttaccgtt    360

tcctcc                                                               366


<210>  10
<211>  321
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide, Antibody G1 light chain variable region 

<400>  10

gaaatcgttc tgacccagtc cccggctacc ctgtccctgt ccccaggtga acgtgctacc     60

ctgtcctgca aagcttccaa acgggttacc acctacgttt cctggtacca gcagaaaccc    120

ggtcaggctc ctcgtctgct gatctacggt gcttccaacc gttacctcgg tatcccagct    180

cgtttctccg gttccggttc cggtaccgac ttcaccctga ccatctcctc cctggaaccc    240

gaagacttcg ctgtttacta ctgcagtcag tcctacaact acccctacac cttcggtcag    300

ggtaccaaac tggaaatcaa a                                              321


<210>  11
<211>  448
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide, Antibody G1 heavy chain

<400>  11

Glu Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Trp Ile Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ala Glu Ile Arg Ser Glu Ser Asp Ala Ser Ala Thr His Tyr Ala Glu 
    50                  55                  60                  


Ala Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn Ser 
65                  70                  75                  80  


Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr 
                85                  90                  95      


Tyr Cys Leu Ala Tyr Phe Asp Tyr Gly Leu Ala Ile Gln Asn Tyr Trp 
            100                 105                 110         


Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro 
        115                 120                 125             


Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr 
    130                 135                 140                 


Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr 
145                 150                 155                 160 


Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro 
                165                 170                 175     


Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr 
            180                 185                 190         


Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp 
        195                 200                 205             


His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys 
    210                 215                 220                 


Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser 
225                 230                 235                 240 


Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg 
                245                 250                 255     


Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro 
            260                 265                 270         


Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala 
        275                 280                 285             


Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val 
    290                 295                 300                 


Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr 
305                 310                 315                 320 


Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr 
                325                 330                 335     


Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu 
            340                 345                 350         


Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys 
        355                 360                 365             


Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser 
    370                 375                 380                 


Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp 
385                 390                 395                 400 


Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser 
                405                 410                 415     


Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala 
            420                 425                 430         


Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445             


<210>  12
<211>  214
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide, Antibody G1 light chain 

<400>  12

Glu Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Leu Ser Pro Gly 
1               5                   10                  15      


Glu Arg Ala Thr Leu Ser Cys Lys Ala Ser Lys Arg Val Thr Thr Tyr 
            20                  25                  30          


Val Ser Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile 
        35                  40                  45              


Tyr Gly Ala Ser Asn Arg Tyr Leu Gly Ile Pro Ala Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Ser Leu Glu Pro 
65                  70                  75                  80  


Glu Asp Phe Ala Val Tyr Tyr Cys Ser Gln Ser Tyr Asn Tyr Pro Tyr 
                85                  90                  95      


Thr Phe Gly Gln Gly Thr Lys Leu Glu Ile Lys Arg Thr Val Ala Ala 
            100                 105                 110         


Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln Leu Lys Ser Gly 
        115                 120                 125             


Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr Pro Arg Glu Ala 
    130                 135                 140                 


Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser Gly Asn Ser Gln 
145                 150                 155                 160 


Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr Tyr Ser Leu Ser 
                165                 170                 175     


Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys His Lys Val Tyr 
            180                 185                 190         


Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro Val Thr Lys Ser 
        195                 200                 205             


Phe Asn Arg Gly Glu Cys 
    210                 


<210>  13
<211>  1347
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide, Antibody G1 heavy chain

<400>  13

gaagttcagc tggttgaatc cggtggtggt ctggttcagc caggtggttc cctgcgtctg     60

tcctgcgctg cttccggttt caccttctcc aactactgga tctcctgggt tcgtcaggct    120

cctggtaaag gtctggaatg ggttgctgaa atccgttccg aatccgacgc gtccgctacc    180

cattacgctg aagctgttaa aggtcgtttc accatctccc gtgacaacgc taagaactcc    240

ctgtacctgc agatgaactc cctgcgtgct gaagacaccg ctgtttacta ctgcctggct    300

tactttgact acggtctggc tatccagaac tactggggtc agggtaccct ggttaccgtt    360

tcctccgcct ccaccaaggg cccatctgtc ttcccactgg ccccatgctc ccgcagcacc    420

tccgagagca cagccgccct gggctgcctg gtcaaggact acttcccaga acctgtgacc    480

gtgtcctgga actctggcgc tctgaccagc ggcgtgcaca ccttcccagc tgtcctgcag    540

tcctcaggtc tctactccct cagcagcgtg gtgaccgtgc catccagcaa cttcggcacc    600

cagacctaca cctgcaacgt agatcacaag ccaagcaaca ccaaggtcga caagaccgtg    660

gagagaaagt gttgtgtgga gtgtccacct tgtccagccc ctccagtggc cggaccatcc    720

gtgttcctgt tccctccaaa gccaaaggac accctgatga tctccagaac cccagaggtg    780

acctgtgtgg tggtggacgt gtcccacgag gacccagagg tgcagttcaa ctggtatgtg    840

gacggagtgg aggtgcacaa cgccaagacc aagccaagag aggagcagtt caactccacc    900

ttcagagtgg tgagcgtgct gaccgtggtg caccaggact ggctgaacgg aaaggagtat    960

aagtgtaagg tgtccaacaa gggactgcca tccagcatcg agaagaccat ctccaagacc   1020

aagggacagc caagagagcc acaggtgtat accctgcccc catccagaga ggagatgacc   1080

aagaaccagg tgtccctgac ctgtctggtg aagggattct atccatccga catcgccgtg   1140

gagtgggagt ccaacggaca gccagagaac aactataaga ccacccctcc aatgctggac   1200

tccgacggat ccttcttcct gtattccaag ctgaccgtgg acaagtccag atggcagcag   1260

ggaaacgtgt tctcttgttc cgtgatgcac gaggccctgc acaaccacta tacccagaag   1320

agcctgtccc tgtctccagg aaagtaa                                       1347


<210>  14
<211>  645
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide, Antibody G1 light chain 

<400>  14

gaaatcgttc tgacccagtc cccggctacc ctgtccctgt ccccaggtga acgtgctacc     60

ctgtcctgca aagcttccaa acgggttacc acctacgttt cctggtacca gcagaaaccc    120

ggtcaggctc ctcgtctgct gatctacggt gcttccaacc gttacctcgg tatcccagct    180

cgtttctccg gttccggttc cggtaccgac ttcaccctga ccatctcctc cctggaaccc    240

gaagacttcg ctgtttacta ctgcagtcag tcctacaact acccctacac cttcggtcag    300

ggtaccaaac tggaaatcaa acgcactgtg gctgcaccat ctgtcttcat cttccctcca    360

tctgatgagc agttgaaatc cggaactgcc tctgttgtgt gcctgctgaa taacttctat    420

ccgcgcgagg ccaaagtaca gtggaaggtg gataacgccc tccaatccgg taactcccag    480

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacc    540

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc    600

ctgagttctc cagtcacaaa gagcttcaac cgcggtgagt gctaa                    645


<210>  15
<211>  37
<212>  PRT
<213>  Homo sapiens


<220>
<223>  Polypeptide, Alpha-CGRP

<400>  15

Ala Cys Asp Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly Leu Leu 
1               5                   10                  15      


Ser Arg Ser Gly Gly Val Val Lys Asn Asn Phe Val Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Lys Ala Phe 
        35          


<210>  16
<211>  37
<212>  PRT
<213>  Homo sapiens


<220>
<223>  Polypeptide, Beta-CGRP

<400>  16

Ala Cys Asn Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly Leu Leu 
1               5                   10                  15      


Ser Arg Ser Gly Gly Met Val Lys Ser Asn Phe Val Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Lys Ala Phe 
        35          


<210>  17
<211>  37
<212>  PRT
<213>  Rattus norvegicus


<220>
<223>  Polypeptide, Alpha-CGRP

<400>  17

Ser Cys Asn Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly Leu Leu 
1               5                   10                  15      


Ser Arg Ser Gly Gly Val Val Lys Asp Asn Phe Val Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Glu Ala Phe 
        35          


<210>  18
<211>  37
<212>  PRT
<213>  Rattus norvegicus


<220>
<223>  Polypeptide, Beta-CGRP

<400>  18

Ser Cys Asn Thr Ala Thr Cys Val Thr His Arg Leu Ala Gly Leu Leu 
1               5                   10                  15      


Ser Arg Ser Gly Gly Val Val Lys Asp Asn Phe Val Pro Thr Asn Val 
            20                  25                  30          


Gly Ser Lys Ala Phe 
        35          


<210>  19
<211>  115
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide, Antibody G2 heavy chain variable region

<400>  19

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Gly Asn Asp Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser 
        115 


<210>  20
<211>  108
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide, Antibody G2 light chain variable region

<400>  20

Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Ile Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Ser Ile 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Phe Ser Pro Lys Val Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Gly Thr Met Glu 
65                  70                  75                  80  


Ala Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Gly Ser Thr Ile Pro 
                85                  90                  95      


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys 
            100                 105             


<210>  21
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide, Antibody G2 Kabat CDR H1

<400>  21

Ser Ser Val Met His 
1               5   


<210>  22
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide, Antibody G2 CDR H2

<400>  22

Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe Lys 
1               5                   10                  15      


Gly 
    


<210>  23
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide, Antibody G2 CDR H3

<400>  23

Gly Gly Asn Asp Gly Tyr 
1               5       


<210>  24
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide, Antibody G2 CDR L1

<400>  24

Ser Ala Ser Ser Ser Ile Ser Ser Ile Tyr Leu His 
1               5                   10          


<210>  25
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide, Antibody G2 CDR L2

<400>  25

Arg Ala Ser Asn Leu Ala Ser 
1               5           


<210>  26
<211>  9
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide, Antibody G2 CDR L3

<400>  26

Gln Gln Gly Ser Thr Ile Pro Phe Thr 
1               5                   


<210>  27
<211>  345
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide, Antibody G2 heavy chain variable region

<400>  27

gaggtccagc tgcagcagtc tggacctgag ctggtaaagc ctggggcttc agtgaagatg     60

tcctgcaagg cttctggata cacattcact agctctgtta tgcactgggt gaagcagaag    120

cctgggcagg gccttgagtg gattggatat attaatcctt acaatgatgg tactaagtac    180

aatgagaagt tcaaaggcaa ggccacactg acttcagaca aatcctccag cacagcctac    240

atggaactca gcagcctgac ctctgaggac tctgcggtct attactgtgc aaaagggggt    300

aacgatggct actggggcca aggcactact ctcacagtct cctca                    345


<210>  28
<211>  324
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide, Antibody G2 light chain variable region

<400>  28

gaaattgtgc tcacccagtc tccaaccacc atggctgcat ctcccgggga gaagatcact     60

atcacctgta gtgccagctc aagtataagt tccatttact tgcattggta tcagcagaag    120

ccaggattct cccctaaagt cttgatttat agggcatcca atctggcttc tggagtccca    180

gctcgcttca gtggcagtgg gtctgggacc tcttactctc tcacaattgg caccatggag    240

gctgaagatg ttgccactta ctactgccag cagggtagta ctataccatt cacgttcggc    300

tcggggacaa agttggaaat aaaa                                           324


<210>  29
<211>  216
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide, Antibody G2 heavy chain 

<400>  29

Glu Val Gln Leu Gln Gln Ser Gly Pro Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Met Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Ser 
            20                  25                  30          


Val Met His Trp Val Lys Gln Lys Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Tyr Ile Asn Pro Tyr Asn Asp Gly Thr Lys Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Lys Gly Lys Ala Thr Leu Thr Ser Asp Lys Ser Ser Ser Thr Ala Tyr 
65                  70                  75                  80  


Met Glu Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Lys Gly Gly Asn Asp Gly Tyr Trp Gly Gln Gly Thr Thr Leu Thr 
            100                 105                 110         


Val Ser Ser Ala Lys Thr Thr Pro Pro Ser Val Tyr Pro Leu Ala Pro 
        115                 120                 125             


Gly Ser Ala Ala Gln Thr Asn Ser Met Val Thr Leu Gly Cys Leu Val 
    130                 135                 140                 


Lys Gly Tyr Phe Pro Glu Pro Val Thr Val Thr Trp Asn Ser Gly Ser 
145                 150                 155                 160 


Leu Ser Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Asp Leu 
                165                 170                 175     


Tyr Thr Leu Ser Ser Ser Val Thr Val Pro Ser Ser Thr Trp Pro Ser 
            180                 185                 190         


Glu Thr Val Thr Cys Asn Val Ala His Pro Ala Ser Ser Thr Lys Val 
        195                 200                 205             


Asp Lys Lys Ile Val Pro Arg Asp 
    210                 215     


<210>  30
<211>  215
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide, Antibody G2 light chain 

<400>  30

Glu Ile Val Leu Thr Gln Ser Pro Thr Thr Met Ala Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Ile Thr Ile Thr Cys Ser Ala Ser Ser Ser Ile Ser Ser Ile 
            20                  25                  30          


Tyr Leu His Trp Tyr Gln Gln Lys Pro Gly Phe Ser Pro Lys Val Leu 
        35                  40                  45              


Ile Tyr Arg Ala Ser Asn Leu Ala Ser Gly Val Pro Ala Arg Phe Ser 
    50                  55                  60                  


Gly Ser Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Gly Thr Met Glu 
65                  70                  75                  80  


Ala Glu Asp Val Ala Thr Tyr Tyr Cys Gln Gln Gly Ser Thr Ile Pro 
                85                  90                  95      


Phe Thr Phe Gly Ser Gly Thr Lys Leu Glu Ile Lys Arg Ala Asp Ala 
            100                 105                 110         


Ala Pro Thr Val Ser Ile Phe Pro Pro Ser Ser Glu Gln Leu Thr Ser 
        115                 120                 125             


Gly Gly Ala Ser Val Val Cys Phe Leu Asn Asn Phe Tyr Pro Arg Asp 
    130                 135                 140                 


Ile Asn Val Lys Trp Lys Ile Asp Gly Ser Glu Arg Gln Asn Gly Val 
145                 150                 155                 160 


Leu Asn Ser Trp Thr Asp Gln Asp Ser Lys Asp Ser Thr Tyr Ser Met 
                165                 170                 175     


Ser Ser Thr Leu Thr Leu Thr Lys Asp Glu Tyr Glu Arg His Asn Ser 
            180                 185                 190         


Tyr Thr Cys Glu Ala Thr His Lys Thr Ser Thr Ser Pro Ile Val Lys 
        195                 200                 205             


Ser Phe Asn Arg Asn Glu Cys 
    210                 215 


<210>  31
<211>  648
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide, Antibody G2 heavy chain 

<400>  31

gaggtccagc tgcagcagtc tggacctgag ctggtaaagc ctggggcttc agtgaagatg     60

tcctgcaagg cttctggata cacattcact agctctgtta tgcactgggt gaagcagaag    120

cctgggcagg gccttgagtg gattggatat attaatcctt acaatgatgg tactaagtac    180

aatgagaagt tcaaaggcaa ggccacactg acttcagaca aatcctccag cacagcctac    240

atggaactca gcagcctgac ctctgaggac tctgcggtct attactgtgc aaaagggggt    300

aacgatggct actggggcca aggcactact ctcacagtct cctcagccaa aacgacaccc    360

ccatctgtct atccactggc ccctggatct gctgcccaaa ctaactccat ggtgaccctg    420

ggatgcctgg tcaagggcta tttccctgag ccagtgacag tgacctggaa ctctggatcc    480

ctgtccagcg gtgtgcacac cttcccagct gtcctgcagt ctgacctcta cactctgagc    540

agctcagtga ctgtcccctc cagcacctgg cccagcgaga ccgtcacctg caacgttgcc    600

cacccggcca gcagcaccaa ggtggacaag aaaattgtgc ccagggat                 648


<210>  32
<211>  648
<212>  DNA
<213>  Artificial sequence

<220>
<223>  Synthetic oligonucleotide, Antibody G2 light chain 

<400>  32

gaaattgtgc tcacccagtc tccaaccacc atggctgcat ctcccgggga gaagatcact     60

atcacctgta gtgccagctc aagtataagt tccatttact tgcattggta tcagcagaag    120

ccaggattct cccctaaagt cttgatttat agggcatcca atctggcttc tggagtccca    180

gctcgcttca gtggcagtgg gtctgggacc tcttactctc tcacaattgg caccatggag    240

gctgaagatg ttgccactta ctactgccag cagggtagta ctataccatt cacgttcggc    300

tcggggacaa agttggaaat aaaacgggct gatgctgcac caactgtatc catcttccca    360

ccatccagtg agcagttaac atctggaggt gcctcagtcg tgtgcttctt gaacaacttc    420

taccccagag acatcaatgt caagtggaag attgatggca gtgaacgaca aaatggtgtc    480

ctgaacagtt ggactgatca ggacagcaaa gacagcacct acagcatgag cagcaccctc    540

acattgacca aggacgagta tgaacgacat aacagctata cctgtgaggc cactcacaag    600

acatcaactt cacccatcgt caagagcttc aacaggaatg agtgttaa                 648



<210>  33
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide, Antibody G1 Chothia CDR H1 

<400>  33

Gly Phe Thr Phe Ser Asn Tyr 
1               5                  


<210>  34
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide, Antibody G1 Kabat CDR H1 

<400>  34

Asn Tyr Trp Ile Ser 
1               5                  


<210>  35
<211>  8
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide, Antibody G1 Chothia CDR H2

<400>  35

Arg Ser Glu Ser Asp Ala Ser Ala 
1               5                  


<210>  36
<211>  10
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide, Antibody G2 extended CDR H1

<400>  36

Gly Tyr Thr Phe Thr Ser Ser Val Met His 
1               5                   10   


<210>  37
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide, Antibody G2 Chothia CDR H1

<400>  37

Gly Tyr Thr Phe Thr Ser Ser
1               5  


<210>  38
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide, Antibody G2 Chothia CDR H2

<400>  38

Asn Pro Tyr Asn Asp Gly 
1               5      


<210>  39
<211>  5
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic polypeptide

<400>  39

Gly Ser Lys Ala Phe
1               5      


