                         SEQUENCE LISTING

<110>  INSTITUT PASTEUR DE LILLE
       INSERM
       CEA
       UNIVERSITE LILLE 2
 
<120>  METHOD FOR DETERMINING THE RISK OF OCCURENCE OF ALZHEIMER'S 
       DISEASE

<130>  BET09P0965

<160>  9     

<170>  PatentIn version 3.4

<210>  1
<211>  2859
<212>  DNA
<213>  Homo sapiens

<400>  1
ctttccgcgg cattctttgg gcgtgagtca tgcaggtttg cagccagccc caaagggggt     60

gtgtgcgcga gcagagcgct ataaatacgg cgcctcccag tgcccacaac gcggcgtcgc    120

caggaggagc gcgcgggcac agggtgccgc tgaccgaggc gtgcaaagac tccagaattg    180

gaggcatgat gaagactctg ctgctgtttg tggggctgct gctgacctgg gagagtgggc    240

aggtcctggg ggaccagacg gtctcagaca atgagctcca ggaaatgtcc aatcagggaa    300

gtaagtacgt caataaggaa attcaaaatg ctgtcaacgg ggtgaaacag ataaagactc    360

tcatagaaaa aacaaacgaa gagcgcaaga cactgctcag caacctagaa gaagccaaga    420

agaagaaaga ggatgcccta aatgagacca gggaatcaga gacaaagctg aaggagctcc    480

caggagtgtg caatgagacc atgatggccc tctgggaaga gtgtaagccc tgcctgaaac    540

agacctgcat gaagttctac gcacgcgtct gcagaagtgg ctcaggcctg gttggccgcc    600

agcttgagga gttcctgaac cagagctcgc ccttctactt ctggatgaat ggtgaccgca    660

tcgactccct gctggagaac gaccggcagc agacgcacat gctggatgtc atgcaggacc    720

acttcagccg cgcgtccagc atcatagacg agctcttcca ggacaggttc ttcacccggg    780

agccccagga tacctaccac tacctgccct tcagcctgcc ccaccggagg cctcacttct    840

tctttcccaa gtcccgcatc gtccgcagct tgatgccctt ctctccgtac gagcccctga    900

acttccacgc catgttccag cccttccttg agatgataca cgaggctcag caggccatgg    960

acatccactt ccatagcccg gccttccagc acccgccaac agaattcata cgagaaggcg   1020

acgatgaccg gactgtgtgc cgggagatcc gccacaactc cacgggctgc ctgcggatga   1080

aggaccagtg tgacaagtgc cgggagatct tgtctgtgga ctgttccacc aacaacccct   1140

cccaggctaa gctgcggcgg gagctcgacg aatccctcca ggtcgctgag aggttgacca   1200

ggaaatacaa cgagctgcta aagtcctacc agtggaagat gctcaacacc tcctccttgc   1260

tggagcagct gaacgagcag tttaactggg tgtcccggct ggcaaacctc acgcaaggcg   1320

aagaccagta ctatctgcgg gtcaccacgg tggcttccca cacttctgac tcggacgttc   1380

cttccggtgt cactgaggtg gtcgtgaagc tctttgactc tgatcccatc actgtgacgg   1440

tccctgtaga agtctccagg aagaacccta aatttatgga gaccgtggcg gagaaagcgc   1500

tgcaggaata ccgcaaaaag caccgggagg agtgagatgt ggatgttgct tttgcaccta   1560

cgggggcatc tgagtccagc tccccccaag atgagctgca gccccccaga gagagctctg   1620

cacgtcacca agtaaccagg ccccagcctc caggccccca actccgccca gcctctcccc   1680

gctctggatc ctgcactcta acactcgact ctgctgctca tgggaagaac agaattgctc   1740

ctgcatgcaa ctaattcaat aaaactgtct tgtgagctga tcgcttggag ggtcctcttt   1800

ttatgttgag ttgctgcttc ccggcatgcc ttcattttgc tatggggggc aggcaggggg   1860

gatggaaaat aagtagaaac aaaaaagcag tggctaagat ggtataggga ctgtcatacc   1920

agtgaagaat aaaagggtga agaataaaag ggatatgatg acaaggttga tccacttcaa   1980

gaattgcttg ctttcaggaa gagagatgtg tttcaacaag ccaactaaaa tatattgctg   2040

caaatggaag cttttctgtt ctattataaa actgtcgatg tattctgacc aaggtgcgac   2100

aatctcctaa aggaatacac tgaaagttaa ggagaagaat cagtaagtgt aaggtgtact   2160

tggtattata atgcataatt gatgttttcg ttatgaaaac atttggtgcc cagaagtcca   2220

aattatcagt tttatttgta agagctattg cttttgcagc ggttttattt gtaaaagctg   2280

ttgatttcga gttgtaagag ctcagcatcc caggggcatc ttcttgactg tggcatttcc   2340

tgtccaccgc cggtttatat gatcttcata cctttccctg gaccacaggc gtttctcggc   2400

ttttagtctg aaccatagct gggctgcagt accctacgct gccagcaggt ggccatgact   2460

acccgtggta ccaatctcag tcttaaagct caggcttttc gttcattaac attctctgat   2520

agaattctgg tcatcagatg tactgcaatg gaacaaaact catctggctg catcccaggt   2580

gtgtagcaaa gtccacatgt aaatttatag cttagaatat tcttaagtca ctgtcccttg   2640

tctctctttg aagttataaa caacaaactt aaagcttagc ttatgtccaa ggtaagtatt   2700

ttagcatggc tgtcaaggaa attcagagta aagtcagtgt gattcactta atgatataca   2760

ttaattagaa ttatggggtc agaggtattt gcttaagtga tcataattgt aaagtatatg   2820

tcacattgtc acattaatgt caaaaaaaaa aaaaaaaaa                          2859


<210>  2
<211>  501
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gln Val Cys Ser Gln Pro Gln Arg Gly Cys Val Arg Glu Gln Ser 
1               5                   10                  15      


Ala Ile Asn Thr Ala Pro Pro Ser Ala His Asn Ala Ala Ser Pro Gly 
            20                  25                  30          


Gly Ala Arg Gly His Arg Val Pro Leu Thr Glu Ala Cys Lys Asp Ser 
        35                  40                  45              


Arg Ile Gly Gly Met Met Lys Thr Leu Leu Leu Phe Val Gly Leu Leu 
    50                  55                  60                  


Leu Thr Trp Glu Ser Gly Gln Val Leu Gly Asp Gln Thr Val Ser Asp 
65                  70                  75                  80  


Asn Glu Leu Gln Glu Met Ser Asn Gln Gly Ser Lys Tyr Val Asn Lys 
                85                  90                  95      


Glu Ile Gln Asn Ala Val Asn Gly Val Lys Gln Ile Lys Thr Leu Ile 
            100                 105                 110         


Glu Lys Thr Asn Glu Glu Arg Lys Thr Leu Leu Ser Asn Leu Glu Glu 
        115                 120                 125             


Ala Lys Lys Lys Lys Glu Asp Ala Leu Asn Glu Thr Arg Glu Ser Glu 
    130                 135                 140                 


Thr Lys Leu Lys Glu Leu Pro Gly Val Cys Asn Glu Thr Met Met Ala 
145                 150                 155                 160 


Leu Trp Glu Glu Cys Lys Pro Cys Leu Lys Gln Thr Cys Met Lys Phe 
                165                 170                 175     


Tyr Ala Arg Val Cys Arg Ser Gly Ser Gly Leu Val Gly Arg Gln Leu 
            180                 185                 190         


Glu Glu Phe Leu Asn Gln Ser Ser Pro Phe Tyr Phe Trp Met Asn Gly 
        195                 200                 205             


Asp Arg Ile Asp Ser Leu Leu Glu Asn Asp Arg Gln Gln Thr His Met 
    210                 215                 220                 


Leu Asp Val Met Gln Asp His Phe Ser Arg Ala Ser Ser Ile Ile Asp 
225                 230                 235                 240 


Glu Leu Phe Gln Asp Arg Phe Phe Thr Arg Glu Pro Gln Asp Thr Tyr 
                245                 250                 255     


His Tyr Leu Pro Phe Ser Leu Pro His Arg Arg Pro His Phe Phe Phe 
            260                 265                 270         


Pro Lys Ser Arg Ile Val Arg Ser Leu Met Pro Phe Ser Pro Tyr Glu 
        275                 280                 285             


Pro Leu Asn Phe His Ala Met Phe Gln Pro Phe Leu Glu Met Ile His 
    290                 295                 300                 


Glu Ala Gln Gln Ala Met Asp Ile His Phe His Ser Pro Ala Phe Gln 
305                 310                 315                 320 


His Pro Pro Thr Glu Phe Ile Arg Glu Gly Asp Asp Asp Arg Thr Val 
                325                 330                 335     


Cys Arg Glu Ile Arg His Asn Ser Thr Gly Cys Leu Arg Met Lys Asp 
            340                 345                 350         


Gln Cys Asp Lys Cys Arg Glu Ile Leu Ser Val Asp Cys Ser Thr Asn 
        355                 360                 365             


Asn Pro Ser Gln Ala Lys Leu Arg Arg Glu Leu Asp Glu Ser Leu Gln 
    370                 375                 380                 


Val Ala Glu Arg Leu Thr Arg Lys Tyr Asn Glu Leu Leu Lys Ser Tyr 
385                 390                 395                 400 


Gln Trp Lys Met Leu Asn Thr Ser Ser Leu Leu Glu Gln Leu Asn Glu 
                405                 410                 415     


Gln Phe Asn Trp Val Ser Arg Leu Ala Asn Leu Thr Gln Gly Glu Asp 
            420                 425                 430         


Gln Tyr Tyr Leu Arg Val Thr Thr Val Ala Ser His Thr Ser Asp Ser 
        435                 440                 445             


Asp Val Pro Ser Gly Val Thr Glu Val Val Val Lys Leu Phe Asp Ser 
    450                 455                 460                 


Asp Pro Ile Thr Val Thr Val Pro Val Glu Val Ser Arg Lys Asn Pro 
465                 470                 475                 480 


Lys Phe Met Glu Thr Val Ala Glu Lys Ala Leu Gln Glu Tyr Arg Lys 
                485                 490                 495     


Lys His Arg Glu Glu 
            500     


<210>  3
<211>  9979
<212>  DNA
<213>  Homo sapiens

<400>  3
ttttgtcccg gaaccccgca gccctcccca cactctgggc gcggagcaca atgattggtc     60

actcctattt tcgctgagct tttcctctta tttcagtttt cttcgagatc aaatctggtt    120

tgtagatgtg cttggggaga atgggggcct cttctccaag aagcccggag cctgtcgggc    180

cgccggcgcc cggtctcccc ttctgctgcg gaggatccct gctggcggtt gtggtgctgc    240

ttgcgctgcc ggtggcctgg ggtcaatgca atgccccaga atggcttcca tttgccaggc    300

ctaccaacct aactgatgaa tttgagtttc ccattgggac atatctgaac tatgaatgcc    360

gccctggtta ttccggaaga ccgttttcta tcatctgcct aaaaaactca gtctggactg    420

gtgctaagga caggtgcaga cgtaaatcat gtcgtaatcc tccagatcct gtgaatggca    480

tggtgcatgt gatcaaaggc atccagttcg gatcccaaat taaatattct tgtactaaag    540

gataccgact cattggttcc tcgtctgcca catgcatcat ctcaggtgat actgtcattt    600

gggataatga aacacctatt tgtgacagaa ttccttgtgg gctacccccc accatcacca    660

atggagattt cattagcacc aacagagaga attttcacta tggatcagtg gtgacctacc    720

gctgcaatcc tggaagcgga gggagaaagg tgtttgagct tgtgggtgag ccctccatat    780

actgcaccag caatgacgat caagtgggca tctggagcgg ccccgcccct cagtgcatta    840

tacctaacaa atgcacgcct ccaaatgtgg aaaatggaat attggtatct gacaacagaa    900

gcttattttc cttaaatgaa gttgtggagt ttaggtgtca gcctggcttt gtcatgaaag    960

gaccccgccg tgtgaagtgc caggccctga acaaatggga gccggagcta ccaagctgct   1020

ccagggtatg tcagccacct ccagatgtcc tgcatgctga gcgtacccaa agggacaagg   1080

acaacttttc acctgggcag gaagtgttct acagctgtga gcccggctac gacctcagag   1140

gggctgcgtc tatgcgctgc acaccccagg gagactggag ccctgcagcc cccacatgtg   1200

aagtgaaatc ctgtgatgac ttcatgggcc aacttcttaa tggccgtgtg ctatttccag   1260

taaatctcca gcttggagca aaagtggatt ttgtttgtga tgaaggattt caattaaaag   1320

gcagctctgc tagttactgt gtcttggctg gaatggaaag cctttggaat agcagtgttc   1380

cagtgtgtga acaaatcttt tgtccaagtc ctccagttat tcctaatggg agacacacag   1440

gaaaacctct ggaagtcttt ccctttggga aaacagtaaa ttacacatgc gacccccacc   1500

cagacagagg gacgagcttc gacctcattg gagagagcac catccgctgc acaagtgacc   1560

ctcaagggaa tggggtttgg agcagccctg cccctcgctg tggaattctg ggtcactgtc   1620

aagccccaga tcattttctg tttgccaagt tgaaaaccca aaccaatgca tctgactttc   1680

ccattgggac atctttaaag tacgaatgcc gtcctgagta ctacgggagg ccattctcta   1740

tcacatgtct agataacctg gtctggtcaa gtcccaaaga tgtctgtaaa cgtaaatcat   1800

gtaaaactcc tccagatcca gtgaatggca tggtgcatgt gatcacagac atccaggttg   1860

gatccagaat caactattct tgtactacag ggcaccgact cattggtcac tcatctgctg   1920

aatgtatcct ctcgggcaat gctgcccatt ggagcacgaa gccgccaatt tgtcaacgaa   1980

ttccttgtgg gctacccccc accatcgcca atggagattt cattagcacc aacagagaga   2040

attttcacta tggatcagtg gtgacctacc gctgcaatcc tggaagcgga gggagaaagg   2100

tgtttgagct tgtgggtgag ccctccatat actgcaccag caatgacgat caagtgggca   2160

tctggagcgg cccggcccct cagtgcatta tacctaacaa atgcacgcct ccaaatgtgg   2220

aaaatggaat attggtatct gacaacagaa gcttattttc cttaaatgaa gttgtggagt   2280

ttaggtgtca gcctggcttt gtcatgaaag gaccccgccg tgtgaagtgc caggccctga   2340

acaaatggga gccggagcta ccaagctgct ccagggtatg tcagccacct ccagatgtcc   2400

tgcatgctga gcgtacccaa agggacaagg acaacttttc acccgggcag gaagtgttct   2460

acagctgtga gcccggctac gacctcagag gggctgcgtc tatgcgctgc acaccccagg   2520

gagactggag ccctgcagcc cccacatgtg aagtgaaatc ctgtgatgac ttcatgggcc   2580

aacttcttaa tggccgtgtg ctatttccag taaatctcca gcttggagca aaagtggatt   2640

ttgtttgtga tgaaggattt caattaaaag gcagctctgc tagttactgt gtcttggctg   2700

gaatggaaag cctttggaat agcagtgttc cagtgtgtga acaaatcttt tgtccaagtc   2760

ctccagttat tcctaatggg agacacacag gaaaacctct ggaagtcttt ccctttggga   2820

aaacagtaaa ttacacatgc gacccccacc cagacagagg gacgagcttc gacctcattg   2880

gagagagcac catccgctgc acaagtgacc ctcaagggaa tggggtttgg agcagccctg   2940

cccctcgctg tggaattctg ggtcactgtc aagccccaga tcattttctg tttgccaagt   3000

tgaaaaccca aaccaatgca tctgactttc ccattgggac atctttaaag tacgaatgcc   3060

gtcctgagta ctacgggagg ccattctcta tcacatgtct agataacctg gtctggtcaa   3120

gtcccaaaga tgtctgtaaa cgtaaatcat gtaaaactcc tccagatcca gtgaatggca   3180

tggtgcatgt gatcacagac atccaggttg gatccagaat caactattct tgtactacag   3240

ggcaccgact cattggtcac tcatctgctg aatgtatcct ctcgggcaat gctgcccatt   3300

ggagcacgaa gccgccaatt tgtcaacgaa ttccttgtgg gctacccccc accatcgcca   3360

atggagattt cattagcacc aacagagaga attttcacta tggatcagtg gtgacctacc   3420

gctgcaatcc tggaagcgga gggagaaagg tgtttgagct tgtgggtgag ccctccatat   3480

actgcaccag caatgacgat caagtgggca tctggagcgg cccggcccct cagtgcatta   3540

tacctaacaa atgcacgcct ccaaatgtgg aaaatggaat attggtatct gacaacagaa   3600

gcttattttc cttaaatgaa gttgtggagt ttaggtgtca gcctggcttt gtcatgaaag   3660

gaccccgccg tgtgaagtgc caggccctga acaaatggga gccggagcta ccaagctgct   3720

ccagggtatg tcagccacct ccagatgtcc tgcatgctga gcgtacccaa agggacaagg   3780

acaacttttc acccgggcag gaagtgttct acagctgtga gcccggctat gacctcagag   3840

gggctgcgtc tatgcgctgc acaccccagg gagactggag ccctgcagcc cccacatgtg   3900

aagtgaaatc ctgtgatgac ttcatgggcc aacttcttaa tggccgtgtg ctatttccag   3960

taaatctcca gcttggagca aaagtggatt ttgtttgtga tgaaggattt caattaaaag   4020

gcagctctgc tagttattgt gtcttggctg gaatggaaag cctttggaat agcagtgttc   4080

cagtgtgtga acaaatcttt tgtccaagtc ctccagttat tcctaatggg agacacacag   4140

gaaaacctct ggaagtcttt ccctttggaa aagcagtaaa ttacacatgc gacccccacc   4200

cagacagagg gacgagcttc gacctcattg gagagagcac catccgctgc acaagtgacc   4260

ctcaagggaa tggggtttgg agcagccctg cccctcgctg tggaattctg ggtcactgtc   4320

aagccccaga tcattttctg tttgccaagt tgaaaaccca aaccaatgca tctgactttc   4380

ccattgggac atctttaaag tacgaatgcc gtcctgagta ctacgggagg ccattctcta   4440

tcacatgtct agataacctg gtctggtcaa gtcccaaaga tgtctgtaaa cgtaaatcat   4500

gtaaaactcc tccagatcca gtgaatggca tggtgcatgt gatcacagac atccaggttg   4560

gatccagaat caactattct tgtactacag ggcaccgact cattggtcac tcatctgctg   4620

aatgtatcct ctcaggcaat actgcccatt ggagcacgaa gccgccaatt tgtcaacgaa   4680

ttccttgtgg gctaccccca accatcgcca atggagattt cattagcacc aacagagaga   4740

attttcacta tggatcagtg gtgacctacc gctgcaatct tggaagcaga gggagaaagg   4800

tgtttgagct tgtgggtgag ccctccatat actgcaccag caatgacgat caagtgggca   4860

tctggagcgg ccccgcccct cagtgcatta tacctaacaa atgcacgcct ccaaatgtgg   4920

aaaatggaat attggtatct gacaacagaa gcttattttc cttaaatgaa gttgtggagt   4980

ttaggtgtca gcctggcttt gtcatgaaag gaccccgccg tgtgaagtgc caggccctga   5040

acaaatggga gccagagtta ccaagctgct ccagggtgtg tcagccgcct ccagaaatcc   5100

tgcatggtga gcatacccca agccatcagg acaacttttc acctgggcag gaagtgttct   5160

acagctgtga gcctggctat gacctcagag gggctgcgtc tctgcactgc acaccccagg   5220

gagactggag ccctgaagcc ccgagatgtg cagtgaaatc ctgtgatgac ttcttgggtc   5280

aactccctca tggccgtgtg ctatttccac ttaatctcca gcttggggca aaggtgtcct   5340

ttgtctgtga tgaagggttt cgcttaaagg gcagttccgt tagtcattgt gtcttggttg   5400

gaatgagaag cctttggaat aacagtgttc ctgtgtgtga acatatcttt tgtccaaatc   5460

ctccagctat ccttaatggg agacacacag gaactccctc tggagatatt ccctatggaa   5520

aagaaatatc ttacacatgt gacccccacc cagacagagg gatgaccttc aacctcattg   5580

gggagagcac catccgctgc acaagtgacc ctcatgggaa tggggtttgg agcagccctg   5640

cccctcgctg tgaactttct gttcgtgctg gtcactgtaa aaccccagag cagtttccat   5700

ttgccagtcc tacgatccca attaatgact ttgagtttcc agtcgggaca tctttgaatt   5760

atgaatgccg tcctgggtat tttgggaaaa tgttctctat ctcctgccta gaaaacttgg   5820

tctggtcaag tgttgaagac aactgtagac gaaaatcatg tggacctcca ccagaaccct   5880

tcaatggaat ggtgcatata aacacagata cacagtttgg atcaacagtt aattattctt   5940

gtaatgaagg gtttcgactc attggttccc catctactac ttgtctcgtc tcaggcaata   6000

atgtcacatg ggataagaag gcacctattt gtgagatcat atcttgtgag ccacctccaa   6060

ccatatccaa tggagacttc tacagcaaca atagaacatc ttttcacaat ggaacggtgg   6120

taacttacca gtgccacact ggaccagatg gagaacagct gtttgagctt gtgggagaac   6180

ggtcaatata ttgcaccagc aaagatgatc aagttggtgt ttggagcagc cctccccctc   6240

ggtgtatttc tactaataaa tgcacagctc cagaagttga aaatgcaatt agagtaccag   6300

gaaacaggag tttctttacc ctcactgaga tcatcagatt tagatgtcag cccgggtttg   6360

tcatggtagg gtcccacact gtgcagtgcc agaccaatgg cagatggggg cccaagctgc   6420

cacactgctc cagggtgtgt cagccgcctc cagaaatcct gcatggtgag cataccctaa   6480

gccatcagga caacttttca cctgggcagg aagtgttcta cagctgtgag cccagctatg   6540

acctcagagg ggctgcgtct ctgcactgca cgccccaggg agactggagc cctgaagccc   6600

ctagatgtac agtgaaatcc tgtgatgact tcctgggcca actccctcat ggccgtgtgc   6660

tacttccact taatctccag cttggggcaa aggtgtcctt tgtttgcgat gaagggttcc   6720

gattaaaagg caggtctgct agtcattgtg tcttggctgg aatgaaagcc ctttggaata   6780

gcagtgttcc agtgtgtgaa caaatctttt gtccaaatcc tccagctatc cttaatggga   6840

gacacacagg aactcccttt ggagatattc cctatggaaa agaaatatct tacgcatgcg   6900

acacccaccc agacagaggg atgaccttca acctcattgg ggagagctcc atccgctgca   6960

caagtgaccc tcaagggaat ggggtttgga gcagccctgc ccctcgctgt gaactttctg   7020

ttcctgctgc ctgcccacat ccacccaaga tccaaaacgg gcattacatt ggaggacacg   7080

tatctctata tcttcctggg atgacaatca gctacatttg tgaccccggc tacctgttag   7140

tgggaaaggg cttcattttc tgtacagacc agggaatctg gagccaattg gatcattatt   7200

gcaaagaagt aaattgtagc ttcccactgt ttatgaatgg aatctcgaag gagttagaaa   7260

tgaaaaaagt atatcactat ggagattatg tgactttgaa gtgtgaagat gggtatactc   7320

tggaaggcag tccctggagc cagtgccagg cggatgacag atgggaccct cctctggcca   7380

aatgtacctc tcgtacacat gatgctctca tagttggcac tttatctggt acgatcttct   7440

ttattttact catcattttc ctctcttgga taattctaaa gcacagaaaa ggcaataatg   7500

cacatgaaaa ccctaaagaa gtggctatcc atttacattc tcaaggaggc agcagcgttc   7560

atccccgaac tctgcaaaca aatgaagaaa atagcagggt ccttccttga caaagtacta   7620

tacagctgaa gaacatctcg aatacaattt tggtgggaaa ggagccaatt gatttcaaca   7680

gaatcagatc tgagcttcat aaagtctttg aagtgacttc acagagacgc agacatgtgc   7740

acttgaagat gctgcccctt ccctggtacc tagcaaagct cctgcctctt tgtgtgcgtc   7800

actgtgaaac ccccaccctt ctgcctcgtg ctaaacgcac acagtatcta gtcaggggaa   7860

aagactgcat ttaggagata gaaaatagtt tggattactt aaaggaataa ggtgttgcct   7920

ggaatttctg gtttgtaagg tggtcactgt tcttttttaa aatatttgta atatggaatg   7980

ggctcagtaa gaagagcttg gaaaatgcag aaagttatga aaaataagtc acttataatt   8040

atgctaccta ctgataacca ctcctaatat tttgattcat tttctgccta tcttctttca   8100

catatgtgtt tttttacata cgtacttttc ccccttagtt tgtttccttt tattttatag   8160

agcagaaccc tagtctttta aacagtttag agtgaaatat atgctatatc agtttttact   8220

ttctctaggg agaaaaatta atttactaga aaggcatgaa atgatcatgg gaagagtggt   8280

taagactact gaagagaaat atttggaaaa taagatttcg atatcttctt tttttttgag   8340

atggagtctg gctctgtctc ccaggctgga gtgcagtggc gtaatctcgg ctcactgcaa   8400

gctccgcctc ccgggttgac accattttcc tgcctcagcc tcctgagtag ttgggattac   8460

cagtagatgg gactacaggc acctgccaac acgcccggct aatttttttg tatttttagt   8520

agagacgggg tttcaccatg ttagccagga tggtctggat ctcctgacct cgtgatccac   8580

ctgcctcggc ctcccaaagt gctgcgatta caggcatgag ccaccgcgcc tggccgcttt   8640

cgatattttc taaactttaa ttcaaaagca ctttgtgctg tgttctatat aaaaaacata   8700

ataaaaattg aaatgaaaga ataattgtta ttataaaagt actagcttac ttttgtatgg   8760

attcagaata tactaaatta actttttaaa acacaacttt taaaaaatgt atcaaaataa   8820

taaacgtgtt ctgatatttt taaaataagt gaccttgtgt tctttaacca gtccacatct   8880

ttagagaaca aaaatgtgtt atgatattat gggccatgct aatgacctct agaaaacatc   8940

agaatatttc tggatattta ataatagctt tatatatgac taatgctcat ttctatgtaa   9000

ttctgtttaa tagttgcttt aaaggtgaat tttgccacat ttactttgac agcagtataa   9060

ggagtgagat agacatgaac ctgaatttca atttaaaatc atggaagaga gggaaaaaaa   9120

accagcttaa gaaaaatcaa ctgataaact gcaagaaaaa aatgcaactt acatcacaaa   9180

agctaattgc tttattattt agagagtact taaaaattaa agaccaaact tctctccacc   9240

caacaaaaat gggcaaagga catacagcta ggtcaccaag aaagaagggc aaataggtgg   9300

tgagtatatg taaagatact tgataggact tttgcttagt tgaatcttta gcaaatctct   9360

tttatttctt gggattttga agaagtaatt tttaaaggag gactagaaac taagtgattg   9420

ggaattggcc tttttagaat taaaatttcc cattacaaga aaaaaaaatc ctgtgttctt   9480

ttttttttcc agaatggagt aggtcagtga gcaatgtgat taataaatat ttcaatgtct   9540

gtgacttttg atttattttg gagacagggt cttgctctgt tacccaggct ggagtgcagt   9600

ggtgctatct aggcttactg caacctcacc tgtcactttt taattgcaag aaagctgaaa   9660

ggtttttttc tattatatca gttataatga taaatactgt atatactaac tatgagtaaa   9720

atactatatt gcctaacttg tattattaag caattctgct aacctgtgac cttacatttt   9780

catctgaaaa gcaggggctg gacaccaatt gccctatgaa gctattgcta gtcctaacat   9840

tctttgtttt gtttgctttt ttggcacact taagtgtgta ctatgaagtt tatgatgctt   9900

taatgaaatt ttctgtctct accattgtaa tgagaaagga ataaaatact ttattttgca   9960

aatctaaaaa aaaaaaaaa                                                9979


<210>  4
<211>  2489
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Gly Ala Ser Ser Pro Arg Ser Pro Glu Pro Val Gly Pro Pro Ala 
1               5                   10                  15      


Pro Gly Leu Pro Phe Cys Cys Gly Gly Ser Leu Leu Ala Val Val Val 
            20                  25                  30          


Leu Leu Ala Leu Pro Val Ala Trp Gly Gln Cys Asn Ala Pro Glu Trp 
        35                  40                  45              


Leu Pro Phe Ala Arg Pro Thr Asn Leu Thr Asp Glu Phe Glu Phe Pro 
    50                  55                  60                  


Ile Gly Thr Tyr Leu Asn Tyr Glu Cys Arg Pro Gly Tyr Ser Gly Arg 
65                  70                  75                  80  


Pro Phe Ser Ile Ile Cys Leu Lys Asn Ser Val Trp Thr Gly Ala Lys 
                85                  90                  95      


Asp Arg Cys Arg Arg Lys Ser Cys Arg Asn Pro Pro Asp Pro Val Asn 
            100                 105                 110         


Gly Met Val His Val Ile Lys Gly Ile Gln Phe Gly Ser Gln Ile Lys 
        115                 120                 125             


Tyr Ser Cys Thr Lys Gly Tyr Arg Leu Ile Gly Ser Ser Ser Ala Thr 
    130                 135                 140                 


Cys Ile Ile Ser Gly Asp Thr Val Ile Trp Asp Asn Glu Thr Pro Ile 
145                 150                 155                 160 


Cys Asp Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Thr Asn Gly Asp 
                165                 170                 175     


Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val Val Thr 
            180                 185                 190         


Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu Leu Val 
        195                 200                 205             


Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val Gly Ile 
    210                 215                 220                 


Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys Thr Pro 
225                 230                 235                 240 


Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser Leu Phe 
                245                 250                 255     


Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe Val Met 
            260                 265                 270         


Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp Glu Pro 
        275                 280                 285             


Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp Val Leu 
    290                 295                 300                 


His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro Gly Gln 
305                 310                 315                 320 


Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly Ala Ala 
                325                 330                 335     


Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala Pro Thr 
            340                 345                 350         


Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu Asn Gly 
        355                 360                 365             


Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val Asp Phe 
    370                 375                 380                 


Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser Tyr Cys 
385                 390                 395                 400 


Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro Val Cys 
                405                 410                 415     


Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly Arg His 
            420                 425                 430         


Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Thr Val Asn Tyr 
        435                 440                 445             


Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu Ile Gly 
    450                 455                 460                 


Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly Val Trp 
465                 470                 475                 480 


Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln Ala Pro 
                485                 490                 495     


Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala Ser Asp 
            500                 505                 510         


Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu Tyr Tyr 
        515                 520                 525             


Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp Ser Ser 
    530                 535                 540                 


Pro Lys Asp Val Cys Lys Arg Lys Ser Cys Lys Thr Pro Pro Asp Pro 
545                 550                 555                 560 


Val Asn Gly Met Val His Val Ile Thr Asp Ile Gln Val Gly Ser Arg 
                565                 570                 575     


Ile Asn Tyr Ser Cys Thr Thr Gly His Arg Leu Ile Gly His Ser Ser 
            580                 585                 590         


Ala Glu Cys Ile Leu Ser Gly Asn Ala Ala His Trp Ser Thr Lys Pro 
        595                 600                 605             


Pro Ile Cys Gln Arg Ile Pro Cys Gly Leu Pro Pro Thr Ile Ala Asn 
    610                 615                 620                 


Gly Asp Phe Ile Ser Thr Asn Arg Glu Asn Phe His Tyr Gly Ser Val 
625                 630                 635                 640 


Val Thr Tyr Arg Cys Asn Pro Gly Ser Gly Gly Arg Lys Val Phe Glu 
                645                 650                 655     


Leu Val Gly Glu Pro Ser Ile Tyr Cys Thr Ser Asn Asp Asp Gln Val 
            660                 665                 670         


Gly Ile Trp Ser Gly Pro Ala Pro Gln Cys Ile Ile Pro Asn Lys Cys 
        675                 680                 685             


Thr Pro Pro Asn Val Glu Asn Gly Ile Leu Val Ser Asp Asn Arg Ser 
    690                 695                 700                 


Leu Phe Ser Leu Asn Glu Val Val Glu Phe Arg Cys Gln Pro Gly Phe 
705                 710                 715                 720 


Val Met Lys Gly Pro Arg Arg Val Lys Cys Gln Ala Leu Asn Lys Trp 
                725                 730                 735     


Glu Pro Glu Leu Pro Ser Cys Ser Arg Val Cys Gln Pro Pro Pro Asp 
            740                 745                 750         


Val Leu His Ala Glu Arg Thr Gln Arg Asp Lys Asp Asn Phe Ser Pro 
        755                 760                 765             


Gly Gln Glu Val Phe Tyr Ser Cys Glu Pro Gly Tyr Asp Leu Arg Gly 
    770                 775                 780                 


Ala Ala Ser Met Arg Cys Thr Pro Gln Gly Asp Trp Ser Pro Ala Ala 
785                 790                 795                 800 


Pro Thr Cys Glu Val Lys Ser Cys Asp Asp Phe Met Gly Gln Leu Leu 
                805                 810                 815     


Asn Gly Arg Val Leu Phe Pro Val Asn Leu Gln Leu Gly Ala Lys Val 
            820                 825                 830         


Asp Phe Val Cys Asp Glu Gly Phe Gln Leu Lys Gly Ser Ser Ala Ser 
        835                 840                 845             


Tyr Cys Val Leu Ala Gly Met Glu Ser Leu Trp Asn Ser Ser Val Pro 
    850                 855                 860                 


Val Cys Glu Gln Ile Phe Cys Pro Ser Pro Pro Val Ile Pro Asn Gly 
865                 870                 875                 880 


Arg His Thr Gly Lys Pro Leu Glu Val Phe Pro Phe Gly Lys Thr Val 
                885                 890                 895     


Asn Tyr Thr Cys Asp Pro His Pro Asp Arg Gly Thr Ser Phe Asp Leu 
            900                 905                 910         


Ile Gly Glu Ser Thr Ile Arg Cys Thr Ser Asp Pro Gln Gly Asn Gly 
        915                 920                 925             


Val Trp Ser Ser Pro Ala Pro Arg Cys Gly Ile Leu Gly His Cys Gln 
    930                 935                 940                 


Ala Pro Asp His Phe Leu Phe Ala Lys Leu Lys Thr Gln Thr Asn Ala 
945                 950                 955                 960 


Ser Asp Phe Pro Ile Gly Thr Ser Leu Lys Tyr Glu Cys Arg Pro Glu 
                965                 970                 975     


Tyr Tyr Gly Arg Pro Phe Ser Ile Thr Cys Leu Asp Asn Leu Val Trp 
            980                 985                 990         


Ser Ser Pro Lys Asp Val Cys Lys  Arg Lys Ser Cys Lys  Thr Pro Pro 
        995                 1000                 1005             


Asp Pro  Val Asn Gly Met Val  His Val Ile Thr Asp  Ile Gln Val 
    1010                 1015                 1020             


Gly Ser  Arg Ile Asn Tyr Ser  Cys Thr Thr Gly His  Arg Leu Ile 
    1025                 1030                 1035             


Gly His  Ser Ser Ala Glu Cys  Ile Leu Ser Gly Asn  Ala Ala His 
    1040                 1045                 1050             


Trp Ser  Thr Lys Pro Pro Ile  Cys Gln Arg Ile Pro  Cys Gly Leu 
    1055                 1060                 1065             


Pro Pro  Thr Ile Ala Asn Gly  Asp Phe Ile Ser Thr  Asn Arg Glu 
    1070                 1075                 1080             


Asn Phe  His Tyr Gly Ser Val  Val Thr Tyr Arg Cys  Asn Pro Gly 
    1085                 1090                 1095             


Ser Gly  Gly Arg Lys Val Phe  Glu Leu Val Gly Glu  Pro Ser Ile 
    1100                 1105                 1110             


Tyr Cys  Thr Ser Asn Asp Asp  Gln Val Gly Ile Trp  Ser Gly Pro 
    1115                 1120                 1125             


Ala Pro  Gln Cys Ile Ile Pro  Asn Lys Cys Thr Pro  Pro Asn Val 
    1130                 1135                 1140             


Glu Asn  Gly Ile Leu Val Ser  Asp Asn Arg Ser Leu  Phe Ser Leu 
    1145                 1150                 1155             


Asn Glu  Val Val Glu Phe Arg  Cys Gln Pro Gly Phe  Val Met Lys 
    1160                 1165                 1170             


Gly Pro  Arg Arg Val Lys Cys  Gln Ala Leu Asn Lys  Trp Glu Pro 
    1175                 1180                 1185             


Glu Leu  Pro Ser Cys Ser Arg  Val Cys Gln Pro Pro  Pro Asp Val 
    1190                 1195                 1200             


Leu His  Ala Glu Arg Thr Gln  Arg Asp Lys Asp Asn  Phe Ser Pro 
    1205                 1210                 1215             


Gly Gln  Glu Val Phe Tyr Ser  Cys Glu Pro Gly Tyr  Asp Leu Arg 
    1220                 1225                 1230             


Gly Ala  Ala Ser Met Arg Cys  Thr Pro Gln Gly Asp  Trp Ser Pro 
    1235                 1240                 1245             


Ala Ala  Pro Thr Cys Glu Val  Lys Ser Cys Asp Asp  Phe Met Gly 
    1250                 1255                 1260             


Gln Leu  Leu Asn Gly Arg Val  Leu Phe Pro Val Asn  Leu Gln Leu 
    1265                 1270                 1275             


Gly Ala  Lys Val Asp Phe Val  Cys Asp Glu Gly Phe  Gln Leu Lys 
    1280                 1285                 1290             


Gly Ser  Ser Ala Ser Tyr Cys  Val Leu Ala Gly Met  Glu Ser Leu 
    1295                 1300                 1305             


Trp Asn  Ser Ser Val Pro Val  Cys Glu Gln Ile Phe  Cys Pro Ser 
    1310                 1315                 1320             


Pro Pro  Val Ile Pro Asn Gly  Arg His Thr Gly Lys  Pro Leu Glu 
    1325                 1330                 1335             


Val Phe  Pro Phe Gly Lys Ala  Val Asn Tyr Thr Cys  Asp Pro His 
    1340                 1345                 1350             


Pro Asp  Arg Gly Thr Ser Phe  Asp Leu Ile Gly Glu  Ser Thr Ile 
    1355                 1360                 1365             


Arg Cys  Thr Ser Asp Pro Gln  Gly Asn Gly Val Trp  Ser Ser Pro 
    1370                 1375                 1380             


Ala Pro  Arg Cys Gly Ile Leu  Gly His Cys Gln Ala  Pro Asp His 
    1385                 1390                 1395             


Phe Leu  Phe Ala Lys Leu Lys  Thr Gln Thr Asn Ala  Ser Asp Phe 
    1400                 1405                 1410             


Pro Ile  Gly Thr Ser Leu Lys  Tyr Glu Cys Arg Pro  Glu Tyr Tyr 
    1415                 1420                 1425             


Gly Arg  Pro Phe Ser Ile Thr  Cys Leu Asp Asn Leu  Val Trp Ser 
    1430                 1435                 1440             


Ser Pro  Lys Asp Val Cys Lys  Arg Lys Ser Cys Lys  Thr Pro Pro 
    1445                 1450                 1455             


Asp Pro  Val Asn Gly Met Val  His Val Ile Thr Asp  Ile Gln Val 
    1460                 1465                 1470             


Gly Ser  Arg Ile Asn Tyr Ser  Cys Thr Thr Gly His  Arg Leu Ile 
    1475                 1480                 1485             


Gly His  Ser Ser Ala Glu Cys  Ile Leu Ser Gly Asn  Thr Ala His 
    1490                 1495                 1500             


Trp Ser  Thr Lys Pro Pro Ile  Cys Gln Arg Ile Pro  Cys Gly Leu 
    1505                 1510                 1515             


Pro Pro  Thr Ile Ala Asn Gly  Asp Phe Ile Ser Thr  Asn Arg Glu 
    1520                 1525                 1530             


Asn Phe  His Tyr Gly Ser Val  Val Thr Tyr Arg Cys  Asn Leu Gly 
    1535                 1540                 1545             


Ser Arg  Gly Arg Lys Val Phe  Glu Leu Val Gly Glu  Pro Ser Ile 
    1550                 1555                 1560             


Tyr Cys  Thr Ser Asn Asp Asp  Gln Val Gly Ile Trp  Ser Gly Pro 
    1565                 1570                 1575             


Ala Pro  Gln Cys Ile Ile Pro  Asn Lys Cys Thr Pro  Pro Asn Val 
    1580                 1585                 1590             


Glu Asn  Gly Ile Leu Val Ser  Asp Asn Arg Ser Leu  Phe Ser Leu 
    1595                 1600                 1605             


Asn Glu  Val Val Glu Phe Arg  Cys Gln Pro Gly Phe  Val Met Lys 
    1610                 1615                 1620             


Gly Pro  Arg Arg Val Lys Cys  Gln Ala Leu Asn Lys  Trp Glu Pro 
    1625                 1630                 1635             


Glu Leu  Pro Ser Cys Ser Arg  Val Cys Gln Pro Pro  Pro Glu Ile 
    1640                 1645                 1650             


Leu His  Gly Glu His Thr Pro  Ser His Gln Asp Asn  Phe Ser Pro 
    1655                 1660                 1665             


Gly Gln  Glu Val Phe Tyr Ser  Cys Glu Pro Gly Tyr  Asp Leu Arg 
    1670                 1675                 1680             


Gly Ala  Ala Ser Leu His Cys  Thr Pro Gln Gly Asp  Trp Ser Pro 
    1685                 1690                 1695             


Glu Ala  Pro Arg Cys Ala Val  Lys Ser Cys Asp Asp  Phe Leu Gly 
    1700                 1705                 1710             


Gln Leu  Pro His Gly Arg Val  Leu Phe Pro Leu Asn  Leu Gln Leu 
    1715                 1720                 1725             


Gly Ala  Lys Val Ser Phe Val  Cys Asp Glu Gly Phe  Arg Leu Lys 
    1730                 1735                 1740             


Gly Ser  Ser Val Ser His Cys  Val Leu Val Gly Met  Arg Ser Leu 
    1745                 1750                 1755             


Trp Asn  Asn Ser Val Pro Val  Cys Glu His Ile Phe  Cys Pro Asn 
    1760                 1765                 1770             


Pro Pro  Ala Ile Leu Asn Gly  Arg His Thr Gly Thr  Pro Ser Gly 
    1775                 1780                 1785             


Asp Ile  Pro Tyr Gly Lys Glu  Ile Ser Tyr Thr Cys  Asp Pro His 
    1790                 1795                 1800             


Pro Asp  Arg Gly Met Thr Phe  Asn Leu Ile Gly Glu  Ser Thr Ile 
    1805                 1810                 1815             


Arg Cys  Thr Ser Asp Pro His  Gly Asn Gly Val Trp  Ser Ser Pro 
    1820                 1825                 1830             


Ala Pro  Arg Cys Glu Leu Ser  Val Arg Ala Gly His  Cys Lys Thr 
    1835                 1840                 1845             


Pro Glu  Gln Phe Pro Phe Ala  Ser Pro Thr Ile Pro  Ile Asn Asp 
    1850                 1855                 1860             


Phe Glu  Phe Pro Val Gly Thr  Ser Leu Asn Tyr Glu  Cys Arg Pro 
    1865                 1870                 1875             


Gly Tyr  Phe Gly Lys Met Phe  Ser Ile Ser Cys Leu  Glu Asn Leu 
    1880                 1885                 1890             


Val Trp  Ser Ser Val Glu Asp  Asn Cys Arg Arg Lys  Ser Cys Gly 
    1895                 1900                 1905             


Pro Pro  Pro Glu Pro Phe Asn  Gly Met Val His Ile  Asn Thr Asp 
    1910                 1915                 1920             


Thr Gln  Phe Gly Ser Thr Val  Asn Tyr Ser Cys Asn  Glu Gly Phe 
    1925                 1930                 1935             


Arg Leu  Ile Gly Ser Pro Ser  Thr Thr Cys Leu Val  Ser Gly Asn 
    1940                 1945                 1950             


Asn Val  Thr Trp Asp Lys Lys  Ala Pro Ile Cys Glu  Ile Ile Ser 
    1955                 1960                 1965             


Cys Glu  Pro Pro Pro Thr Ile  Ser Asn Gly Asp Phe  Tyr Ser Asn 
    1970                 1975                 1980             


Asn Arg  Thr Ser Phe His Asn  Gly Thr Val Val Thr  Tyr Gln Cys 
    1985                 1990                 1995             


His Thr  Gly Pro Asp Gly Glu  Gln Leu Phe Glu Leu  Val Gly Glu 
    2000                 2005                 2010             


Arg Ser  Ile Tyr Cys Thr Ser  Lys Asp Asp Gln Val  Gly Val Trp 
    2015                 2020                 2025             


Ser Ser  Pro Pro Pro Arg Cys  Ile Ser Thr Asn Lys  Cys Thr Ala 
    2030                 2035                 2040             


Pro Glu  Val Glu Asn Ala Ile  Arg Val Pro Gly Asn  Arg Ser Phe 
    2045                 2050                 2055             


Phe Thr  Leu Thr Glu Ile Ile  Arg Phe Arg Cys Gln  Pro Gly Phe 
    2060                 2065                 2070             


Val Met  Val Gly Ser His Thr  Val Gln Cys Gln Thr  Asn Gly Arg 
    2075                 2080                 2085             


Trp Gly  Pro Lys Leu Pro His  Cys Ser Arg Val Cys  Gln Pro Pro 
    2090                 2095                 2100             


Pro Glu  Ile Leu His Gly Glu  His Thr Leu Ser His  Gln Asp Asn 
    2105                 2110                 2115             


Phe Ser  Pro Gly Gln Glu Val  Phe Tyr Ser Cys Glu  Pro Ser Tyr 
    2120                 2125                 2130             


Asp Leu  Arg Gly Ala Ala Ser  Leu His Cys Thr Pro  Gln Gly Asp 
    2135                 2140                 2145             


Trp Ser  Pro Glu Ala Pro Arg  Cys Thr Val Lys Ser  Cys Asp Asp 
    2150                 2155                 2160             


Phe Leu  Gly Gln Leu Pro His  Gly Arg Val Leu Leu  Pro Leu Asn 
    2165                 2170                 2175             


Leu Gln  Leu Gly Ala Lys Val  Ser Phe Val Cys Asp  Glu Gly Phe 
    2180                 2185                 2190             


Arg Leu  Lys Gly Arg Ser Ala  Ser His Cys Val Leu  Ala Gly Met 
    2195                 2200                 2205             


Lys Ala  Leu Trp Asn Ser Ser  Val Pro Val Cys Glu  Gln Ile Phe 
    2210                 2215                 2220             


Cys Pro  Asn Pro Pro Ala Ile  Leu Asn Gly Arg His  Thr Gly Thr 
    2225                 2230                 2235             


Pro Phe  Gly Asp Ile Pro Tyr  Gly Lys Glu Ile Ser  Tyr Ala Cys 
    2240                 2245                 2250             


Asp Thr  His Pro Asp Arg Gly  Met Thr Phe Asn Leu  Ile Gly Glu 
    2255                 2260                 2265             


Ser Ser  Ile Arg Cys Thr Ser  Asp Pro Gln Gly Asn  Gly Val Trp 
    2270                 2275                 2280             


Ser Ser  Pro Ala Pro Arg Cys  Glu Leu Ser Val Pro  Ala Ala Cys 
    2285                 2290                 2295             


Pro His  Pro Pro Lys Ile Gln  Asn Gly His Tyr Ile  Gly Gly His 
    2300                 2305                 2310             


Val Ser  Leu Tyr Leu Pro Gly  Met Thr Ile Ser Tyr  Ile Cys Asp 
    2315                 2320                 2325             


Pro Gly  Tyr Leu Leu Val Gly  Lys Gly Phe Ile Phe  Cys Thr Asp 
    2330                 2335                 2340             


Gln Gly  Ile Trp Ser Gln Leu  Asp His Tyr Cys Lys  Glu Val Asn 
    2345                 2350                 2355             


Cys Ser  Phe Pro Leu Phe Met  Asn Gly Ile Ser Lys  Glu Leu Glu 
    2360                 2365                 2370             


Met Lys  Lys Val Tyr His Tyr  Gly Asp Tyr Val Thr  Leu Lys Cys 
    2375                 2380                 2385             


Glu Asp  Gly Tyr Thr Leu Glu  Gly Ser Pro Trp Ser  Gln Cys Gln 
    2390                 2395                 2400             


Ala Asp  Asp Arg Trp Asp Pro  Pro Leu Ala Lys Cys  Thr Ser Arg 
    2405                 2410                 2415             


Thr His  Asp Ala Leu Ile Val  Gly Thr Leu Ser Gly  Thr Ile Phe 
    2420                 2425                 2430             


Phe Ile  Leu Leu Ile Ile Phe  Leu Ser Trp Ile Ile  Leu Lys His 
    2435                 2440                 2445             


Arg Lys  Gly Asn Asn Ala His  Glu Asn Pro Lys Glu  Val Ala Ile 
    2450                 2455                 2460             


His Leu  His Ser Gln Gly Gly  Ser Ser Val His Pro  Arg Thr Leu 
    2465                 2470                 2475             


Gln Thr  Asn Glu Glu Asn Ser  Arg Val Leu Pro 
    2480                 2485                 


<210>  5
<211>  52
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  c or t

<400>  5
cttctgataa ggaagtcctc ctgctnctcc aaggaaacct agagagctga cc             52


<210>  6
<211>  52
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  c or t

<400>  6
caccaaagcc acaccagcta tcaaaantct ctaacgggcc cttgccactt ga             52


<210>  7
<211>  52
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  c or g

<400>  7
agagcaagag gactcatcct tccaaangga ctttctctgg gaagcctgct cc             52


<210>  8
<211>  52
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (27)..(27)
<223>  a or g

<400>  8
atttccttct ctgtctccat cttctcntcg ccttctcctc tgtgtgtgtc ct             52


<210>  9
<211>  52
<212>  DNA
<213>  Homo sapiens


<220>
<221>  misc_feature
<222>  (26)..(26)
<223>  a or g

<400>  9
agccctctgg taagcataag atatancaaa ggaaattgcc ccatatctaa ca             52


