                         SEQUENCE LISTING

<110>  Novo Nordisk A/S
 
<120>  Targeting tissue factor to activated platelets

<130>  8076.204-WO

<150>  EP09168833.3
<151>  2009-08-27

<160>  163   

<170>  PatentIn version 3.5

<210>  1
<211>  933
<212>  DNA
<213>  Homo sapiens

<400>  1
atgggcctca ccctgctctt gctgctgctc ctgggactag aaggtcaggg catagttggc       60

agcctccctg aggtgctgca ggcacccgtg ggaagctcca ttctggtgca gtgccactac      120

aggctccagg atgtcaaagc tcagaaggtg tggtgccggt tcttgccgga ggggtgccag      180

cccctggtgt cctcagctgt ggatcgcaga gctccagcgg gcaggcgtac gtttctcaca      240

gacctgggtg ggggcctgct gcaggtggaa atggttaccc tgcaggaaga ggatgctggc      300

gagtatggct gcatggtgga tggggccagg gggccccaga ttttgcacag agtctctctg      360

aacatactgc ccccagagga agaagaagag acccataaga ttggcagtct ggctgagaac      420

gcattctcag accctgcagg cagtgccaac cctttggaac ccagccagga tgagaagagc      480

atccccttga tctggggtgc tgtgctcctg gtaggtctgc tggtggcagc ggtggtgctg      540

tttgctgtga tggccaagag gaaacaaggg aacaggcttg gtgtctgtgg ccgattcctg      600

agcagcagag tttcaggcat gaatccctcc tcagtggtcc accacgtcag tgactctgga      660

ccggctgctg aattgccttt ggatgtacca cacattaggc ttgactcacc accttcattt      720

gacaatacca cctacaccag cctacctctt gattccccat caggaaaacc ttcactccca      780

gctccatcct cattgccccc tctacctcct aaggtcctgg tctgctccaa gcctgtgaca      840

tatgccacag taatcttccc gggagggaac aagggtggag ggacctcgtg tgggccagcc      900

cagaatccac ctaacaatca gactccatcc agc                                   933


<210>  2
<211>  311
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Gly Leu Thr Leu Leu Leu Leu Leu Leu Leu Gly Leu Glu Gly Gln 
1               5                   10                  15      


Gly Ile Val Gly Ser Leu Pro Glu Val Leu Gln Ala Pro Val Gly Ser 
            20                  25                  30          


Ser Ile Leu Val Gln Cys His Tyr Arg Leu Gln Asp Val Lys Ala Gln 
        35                  40                  45              


Lys Val Trp Cys Arg Phe Leu Pro Glu Gly Cys Gln Pro Leu Val Ser 
    50                  55                  60                  


Ser Ala Val Asp Arg Arg Ala Pro Ala Gly Arg Arg Thr Phe Leu Thr 
65                  70                  75                  80  


Asp Leu Gly Gly Gly Leu Leu Gln Val Glu Met Val Thr Leu Gln Glu 
                85                  90                  95      


Glu Asp Ala Gly Glu Tyr Gly Cys Met Val Asp Gly Ala Arg Gly Pro 
            100                 105                 110         


Gln Ile Leu His Arg Val Ser Leu Asn Ile Leu Pro Pro Glu Glu Glu 
        115                 120                 125             


Glu Glu Thr His Lys Ile Gly Ser Leu Ala Glu Asn Ala Phe Ser Asp 
    130                 135                 140                 


Pro Ala Gly Ser Ala Asn Pro Leu Glu Pro Ser Gln Asp Glu Lys Ser 
145                 150                 155                 160 


Ile Pro Leu Ile Trp Gly Ala Val Leu Leu Val Gly Leu Leu Val Ala 
                165                 170                 175     


Ala Val Val Leu Phe Ala Val Met Ala Lys Arg Lys Gln Gly Asn Arg 
            180                 185                 190         


Leu Gly Val Cys Gly Arg Phe Leu Ser Ser Arg Val Ser Gly Met Asn 
        195                 200                 205             


Pro Ser Ser Val Val His His Val Ser Asp Ser Gly Pro Ala Ala Glu 
    210                 215                 220                 


Leu Pro Leu Asp Val Pro His Ile Arg Leu Asp Ser Pro Pro Ser Phe 
225                 230                 235                 240 


Asp Asn Thr Thr Tyr Thr Ser Leu Pro Leu Asp Ser Pro Ser Gly Lys 
                245                 250                 255     


Pro Ser Leu Pro Ala Pro Ser Ser Leu Pro Pro Leu Pro Pro Lys Val 
            260                 265                 270         


Leu Val Cys Ser Lys Pro Val Thr Tyr Ala Thr Val Ile Phe Pro Gly 
        275                 280                 285             


Gly Asn Lys Gly Gly Gly Thr Ser Cys Gly Pro Ala Gln Asn Pro Pro 
    290                 295                 300                 


Asn Asn Gln Thr Pro Ser Ser 
305                 310     


<210>  3
<211>  528
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "extracellular domain of hTLT-1-His6"

<400>  3
aagcttgccg ccaccatggg cctcaccctg ctcttgctgc tgctcctggg actagaaggt       60

cagggcatag ttggcagcct ccctgaggtg ctgcaggcac ccgtgggaag ctccattctg      120

gtgcagtgcc actacaggct ccaggatgtc aaagctcaga aggtgtggtg ccggttcttg      180

ccggaggggt gccagcccct ggtgtcctca gctgtggatc gcagagctcc ggcgggcagg      240

cgtacgtttc tcacagacct gggtgggggc ctgctgcagg tggaaatggt taccctgcag      300

gaagaggatg ctggcgagta tggctgcatg gtggatgggg ccagggggcc ccagattttg      360

cacagagtct ctctgaacat actgccccca gaggaagaag aagagaccca taagattggc      420

agtctggctg agaacgcatt ctcagaccct gcaggcagtg ccaacccttt ggaacccagc      480

caggatgaga agagcatccc ccaccatcac catcaccatt aagaattc                   528


<210>  4
<211>  168
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "extracellular domain of hTLT-1-His6"

<400>  4

Met Gly Leu Thr Leu Leu Leu Leu Leu Leu Leu Gly Leu Glu Gly Gln 
1               5                   10                  15      


Gly Ile Val Gly Ser Leu Pro Glu Val Leu Gln Ala Pro Val Gly Ser 
            20                  25                  30          


Ser Ile Leu Val Gln Cys His Tyr Arg Leu Gln Asp Val Lys Ala Gln 
        35                  40                  45              


Lys Val Trp Cys Arg Phe Leu Pro Glu Gly Cys Gln Pro Leu Val Ser 
    50                  55                  60                  


Ser Ala Val Asp Arg Arg Ala Pro Ala Gly Arg Arg Thr Phe Leu Thr 
65                  70                  75                  80  


Asp Leu Gly Gly Gly Leu Leu Gln Val Glu Met Val Thr Leu Gln Glu 
                85                  90                  95      


Glu Asp Ala Gly Glu Tyr Gly Cys Met Val Asp Gly Ala Arg Gly Pro 
            100                 105                 110         


Gln Ile Leu His Arg Val Ser Leu Asn Ile Leu Pro Pro Glu Glu Glu 
        115                 120                 125             


Glu Glu Thr His Lys Ile Gly Ser Leu Ala Glu Asn Ala Phe Ser Asp 
    130                 135                 140                 


Pro Ala Gly Ser Ala Asn Pro Leu Glu Pro Ser Gln Asp Glu Lys Ser 
145                 150                 155                 160 


Ile Pro His His His His His His 
                165             


<210>  5
<211>  106
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "hTLT-1.20-125"

<400>  5

Gly Ser Leu Pro Glu Val Leu Gln Ala Pro Val Gly Ser Ser Ile Leu 
1               5                   10                  15      


Val Gln Cys His Tyr Arg Leu Gln Asp Val Lys Ala Gln Lys Val Trp 
            20                  25                  30          


Cys Arg Phe Leu Pro Glu Gly Cys Gln Pro Leu Val Ser Ser Ala Val 
        35                  40                  45              


Asp Arg Arg Ala Pro Ala Gly Arg Arg Thr Phe Leu Thr Asp Leu Gly 
    50                  55                  60                  


Gly Gly Leu Leu Gln Val Glu Met Val Thr Leu Gln Glu Glu Asp Ala 
65                  70                  75                  80  


Gly Glu Tyr Gly Cys Met Val Asp Gly Ala Arg Gly Pro Gln Ile Leu 
                85                  90                  95      


His Arg Val Ser Leu Asn Ile Leu Pro Pro 
            100                 105     


<210>  6
<211>  147
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "hTLT-1.16-162"

<400>  6

Gln Gly Ile Val Gly Ser Leu Pro Glu Val Leu Gln Ala Pro Val Gly 
1               5                   10                  15      


Ser Ser Ile Leu Val Gln Cys His Tyr Arg Leu Gln Asp Val Lys Ala 
            20                  25                  30          


Gln Lys Val Trp Cys Arg Phe Leu Pro Glu Gly Cys Gln Pro Leu Val 
        35                  40                  45              


Ser Ser Ala Val Asp Arg Arg Ala Pro Ala Gly Arg Arg Thr Phe Leu 
    50                  55                  60                  


Thr Asp Leu Gly Gly Gly Leu Leu Gln Val Glu Met Val Thr Leu Gln 
65                  70                  75                  80  


Glu Glu Asp Ala Gly Glu Tyr Gly Cys Met Val Asp Gly Ala Arg Gly 
                85                  90                  95      


Pro Gln Ile Leu His Arg Val Ser Leu Asn Ile Leu Pro Pro Glu Glu 
            100                 105                 110         


Glu Glu Glu Thr His Lys Ile Gly Ser Leu Ala Glu Asn Ala Phe Ser 
        115                 120                 125             


Asp Pro Ala Gly Ser Ala Asn Pro Leu Glu Pro Ser Gln Asp Glu Lys 
    130                 135                 140                 


Ser Ile Pro 
145         


<210>  7
<211>  37
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "hTLT-1.126-162"

<400>  7

Glu Glu Glu Glu Glu Thr His Lys Ile Gly Ser Leu Ala Glu Asn Ala 
1               5                   10                  15      


Phe Ser Asp Pro Ala Gly Ser Ala Asn Pro Leu Glu Pro Ser Gln Asp 
            20                  25                  30          


Glu Lys Ser Ile Pro 
        35          


<210>  8
<211>  14
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "hTLT-1.129-142"

<400>  8

Glu Glu Thr His Lys Ile Gly Ser Leu Ala Glu Asn Ala Phe 
1               5                   10                  


<210>  9
<211>  396
<212>  DNA
<213>  Homo sapiens

<400>  9
atgaagttgc ctgttgggct gttggtgctg atgttctgga ttccagcttc cagcagtgat       60

gttgtgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc      120

tcttgcagat ctagtcagag ccttgtacac agaaatggaa acacctattt tcattggtgc      180

ctgcagaaac caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct      240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc      300

agagtggagg ctgaggatct gggagtttat ttctgctctc aaagtacaca tgttccgtac      360

acgttcggag gggggaccaa gctggaaata aaacgt                                396


<210>  10
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Lys Leu Pro Val Gly Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Val His Arg Asn Gly Asn Thr Tyr Phe His Trp Cys Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            100                 105                 110         


Ser Gln Ser Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg 
    130         


<210>  11
<211>  396
<212>  DNA
<213>  Homo sapiens

<400>  11
atggattttg ggctgatttt ttttattgtt gctcttttaa aaggggtcca gtgtgaggtg       60

aaacttctcg agtctggagg tggcctggtg cagcctggag gatccctgaa actctcctgt      120

gcagcctcag gattcgattt tagtagatac tggatgactt gggtccggca ggctccaggg      180

aaagggctag aatggattgg agaaattaat ccagatagca gtacgataaa ctatacgcca      240

tctctaaagg ataaattcat catctccaga gacaacgcca agaatacgct gtacctgcaa      300

atgagcgaag tgagatctga ggacacagcc ctttattact gtgcaagcgg ggtgtttact      360

tcctggggcc aagggactct ggtcactgtc tctgca                                396


<210>  12
<211>  132
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Asp Phe Gly Leu Ile Phe Phe Ile Val Ala Leu Leu Lys Gly Val 
1               5                   10                  15      


Gln Cys Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser 
        35                  40                  45              


Arg Tyr Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Pro 
65                  70                  75                  80  


Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr 
                85                  90                  95      


Leu Tyr Leu Gln Met Ser Glu Val Arg Ser Glu Asp Thr Ala Leu Tyr 
            100                 105                 110         


Tyr Cys Ala Ser Gly Val Phe Thr Ser Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ala 
    130         


<210>  13
<211>  657
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "TF (1-219)"

<400>  13
tcaggcacta caaatactgt ggcagcatat aatttaactt ggaaatcaac taatttcaag       60

acaattttgg agtgggaacc caaacccgtc aatcaagtct acactgttca aataagcact      120

aagtcaggag attggaaaag caaatgcttt tacacaacag acacagagtg tgacctcacc      180

gacgagattg tgaaggatgt gaagcagacg tacttggcac gggtcttctc ctacccggca      240

gggaatgtgg agagcaccgg ttctgctggg gagcctctgt atgagaactc cccagagttc      300

acaccttacc tggagacaaa cctcggacag ccaacaattc agagttttga acaggtggga      360

acaaaagtga atgtgaccgt agaagatgaa cggactttag tcagaaggaa caacactttc      420

ctaagcctcc gggatgtttt tggcaaggac ttaatttata cactttatta ttggaaatct      480

tcaagttcag gaaagaaaac agccaaaaca aacactaatg agtttttgat tgatgtggat      540

aaaggagaaa actactgttt cagtgttcaa gcagtgattc cctcccgaac agttaaccgg      600

aagagtacag acagcccggt agagtgtatg ggccaggaga aaggggaatt tagagaa         657


<210>  14
<211>  219
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "TF (1-219)"

<400>  14

Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser 
1               5                   10                  15      


Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln 
            20                  25                  30          


Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys 
        35                  40                  45              


Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val 
    50                  55                  60                  


Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala 
65                  70                  75                  80  


Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn 
                85                  90                  95      


Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr 
            100                 105                 110         


Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu 
        115                 120                 125             


Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg 
    130                 135                 140                 


Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser 
145                 150                 155                 160 


Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu 
                165                 170                 175     


Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val 
            180                 185                 190         


Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu 
        195                 200                 205             


Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu 
    210                 215                 


<210>  15
<211>  885
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "human tissue factor"

<400>  15
atggagaccc ctgcctggcc ccgggtcccg cgccccgaga ccgccgtcgc tcggacgctc       60

ctgctcggct gggtcttcgc ccaggtggcc ggcgcttcag gcactacaaa tactgtggca      120

gcatataatt taacttggaa atcaactaat ttcaagacaa ttttggagtg ggaacccaaa      180

cccgtcaatc aagtctacac tgttcaaata agcactaagt caggagattg gaaaagcaaa      240

tgcttttaca caacagacac agagtgtgac ctcaccgacg agattgtgaa ggatgtgaag      300

cagacgtact tggcacgggt cttctcctac ccggcaggga atgtggagag caccggttct      360

gctggggagc ctctgtatga gaactcccca gagttcacac cttacctgga gacaaacctc      420

ggacagccaa caattcagag ttttgaacag gtgggaacaa aagtgaatgt gaccgtagaa      480

gatgaacgga ctttagtcag aaggaacaac actttcctaa gcctccggga tgtttttggc      540

aaggacttaa tttatacact ttattattgg aaatcttcaa gttcaggaaa gaaaacagcc      600

aaaacaaaca ctaatgagtt tttgattgat gtggataaag gagaaaacta ctgtttcagt      660

gttcaagcag tgattccctc ccgaacagtt aaccggaaga gtacagacag cccggtagag      720

tgtatgggcc aggagaaagg ggaattcaga gaaatattct acatcattgg agctgtggta      780

tttgtggtca tcatccttgt catcatcctg gctatatctc tacacaagtg tagaaaggca      840

ggagtggggc agagctggaa ggagaactcc ccactgaatg tttca                      885


<210>  16
<211>  295
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "human tissue factor"

<400>  16

Met Glu Thr Pro Ala Trp Pro Arg Val Pro Arg Pro Glu Thr Ala Val 
1               5                   10                  15      


Ala Arg Thr Leu Leu Leu Gly Trp Val Phe Ala Gln Val Ala Gly Ala 
            20                  25                  30          


Ser Gly Thr Thr Asn Thr Val Ala Ala Tyr Asn Leu Thr Trp Lys Ser 
        35                  40                  45              


Thr Asn Phe Lys Thr Ile Leu Glu Trp Glu Pro Lys Pro Val Asn Gln 
    50                  55                  60                  


Val Tyr Thr Val Gln Ile Ser Thr Lys Ser Gly Asp Trp Lys Ser Lys 
65                  70                  75                  80  


Cys Phe Tyr Thr Thr Asp Thr Glu Cys Asp Leu Thr Asp Glu Ile Val 
                85                  90                  95      


Lys Asp Val Lys Gln Thr Tyr Leu Ala Arg Val Phe Ser Tyr Pro Ala 
            100                 105                 110         


Gly Asn Val Glu Ser Thr Gly Ser Ala Gly Glu Pro Leu Tyr Glu Asn 
        115                 120                 125             


Ser Pro Glu Phe Thr Pro Tyr Leu Glu Thr Asn Leu Gly Gln Pro Thr 
    130                 135                 140                 


Ile Gln Ser Phe Glu Gln Val Gly Thr Lys Val Asn Val Thr Val Glu 
145                 150                 155                 160 


Asp Glu Arg Thr Leu Val Arg Arg Asn Asn Thr Phe Leu Ser Leu Arg 
                165                 170                 175     


Asp Val Phe Gly Lys Asp Leu Ile Tyr Thr Leu Tyr Tyr Trp Lys Ser 
            180                 185                 190         


Ser Ser Ser Gly Lys Lys Thr Ala Lys Thr Asn Thr Asn Glu Phe Leu 
        195                 200                 205             


Ile Asp Val Asp Lys Gly Glu Asn Tyr Cys Phe Ser Val Gln Ala Val 
    210                 215                 220                 


Ile Pro Ser Arg Thr Val Asn Arg Lys Ser Thr Asp Ser Pro Val Glu 
225                 230                 235                 240 


Cys Met Gly Gln Glu Lys Gly Glu Phe Arg Glu Ile Phe Tyr Ile Ile 
                245                 250                 255     


Gly Ala Val Val Phe Val Val Ile Ile Leu Val Ile Ile Leu Ala Ile 
            260                 265                 270         


Ser Leu His Lys Cys Arg Lys Ala Gly Val Gly Gln Ser Trp Lys Glu 
        275                 280                 285             


Asn Ser Pro Leu Asn Val Ser 
    290                 295 


<210>  17
<211>  1377
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "mAb 0012 HC"

<400>  17
atggattttg ggctgatttt ttttattgtt gctcttttaa aaggggtcca gtgtgaggtg       60

aaacttctcg agtctggagg tggcctggtg cagcctggag gatccctgaa actctcctgt      120

gcagcctcag gattcgattt tagtagatac tggatgactt gggtccggca ggctccaggg      180

aaagggctag aatggattgg agaaattaat ccagatagca gtacgataaa ctatacgcca      240

tctctaaagg ataaattcat catctccaga gacaacgcca agaatacgct gtacctgcaa      300

atgagcgaag tgagatctga ggacacagcc ctttattact gtgcaagcgg ggtgtttact      360

tcctggggcc aagggactct ggtcactgtc tctgcagcta gcaccaaggg cccatccgtc      420

ttccccctgg cgccctgctc caggagcacc tccgagagca cagccgccct gggctgcctg      480

gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc cctgaccagc      540

ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct cagcagcgtg      600

gtgaccgtgc cctccagcag cttgggcacg aagacctaca cctgcaacgt agatcacaag      660

cccagcaaca ccaaggtgga caagagagtt gagtccaaat atggtccccc atgcccacca      720

tgcccagcac ctgagttcct ggggggacca tcagtcttcc tgttcccccc aaaacccaag      780

gacactctca tgatctcccg gacccctgag gtcacgtgcg tggtggtgga cgtgagccag      840

gaagaccccg aggtccagtt caactggtac gtggatggcg tggaggtgca taatgccaag      900

acaaagccgc gggaggagca gttcaacagc acgtaccgtg tggtcagcgt cctcaccgtc      960

ctgcaccagg actggctgaa cggcaaggag tacaagtgca aggtctccaa caaaggcctc     1020

ccgtcctcca tcgagaaaac catctccaaa gccaaagggc agccccgaga gccacaggtg     1080

tacaccctgc ccccatccca ggaggagatg accaagaacc aggtcagcct gacctgcctg     1140

gtcaaaggct tctaccccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1200

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1260

aggctaaccg tggacaagag caggtggcag gaggggaatg tcttctcatg ctccgtgatg     1320

catgaggctc tgcacaacca ctacacacag aagagcctct ccctgtctct gggtaaa        1377


<210>  18
<211>  714
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "mAb 0012 LC, Fab 0012 LC"

<400>  18
atgaagttgc ctgttgggct gttggtgctg atgttctgga ttccagcttc cagcagtgat       60

gttgtgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc      120

tcttgcagat ctagtcagag ccttgtacac agaaatggaa acacctattt tcattggtgc      180

ctgcagaaac caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct      240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc      300

agagtggagg ctgaggatct gggagtttat ttctgctctc aaagtacaca tgttccgtac      360

acgttcggag gggggaccaa gctggaaata aaacgtacgg tggctgcacc atctgtcttc      420

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      480

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      540

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      600

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      660

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgt            714


<210>  19
<211>  1401
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "mAb 0023 HC"

<400>  19
atgaacttgg ggctcagctt gattttcctt gtccttgttt taaaaggtgt ccagtgtgaa       60

gtgaggctgg tggagtctgg gggaggctta gtgcagcctg gagggtccct gaaactctcc      120

tgtgcaacct ctggattcac tttcagtgac tatttcatgt attggattcg ccagactcca      180

gagaagaggc tggagtgggt cgcatacatt agtaatggtg gtgatagcag ctcttatcca      240

gacactgtaa agggccgatt caccatctcc agagacaatg ccaagaacac cctgtacctg      300

caaatgagcc gtctgaagtc tgaggacaca gccatgtatt attgtgcaac aaataaaaac      360

tgggacgatt actatgatat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      420

gctagcacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag      480

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      540

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      660

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      720

aaatatggtc ccccatgccc accatgccca gcacctgagt tcctgggggg accatcagtc      780

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      840

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa     1080

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg     1320

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc     1380

ctctccctgt ctctgggtaa a                                               1401


<210>  20
<211>  717
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "mAb 0023 LC"

<400>  20
atggattcac aggcccaggt tcttatattg ctgctgctat gggtatctgg ttcctgtggg       60

gacattgtgg tgtcacagtc tccatcctcc ctggctgtgt cagcaggaga gaaggtcact      120

atgagttgca aatccagtca gagtctgctc aacagtagaa cccgaaagaa ctacttggct      180

tggtaccagc agaaaccagg gcagtctcct aaactgctga tctactgggc atccactagg      240

gaatctgggg tccctgatcg cttcacaggc agtggatctg ggacagattt cactctcacc      300

atcagcagtg tgcaggctga agacctggca gtttattact gcaagcaatc ttataatctg      360

ctcacgttcg gtgctgggac caagctggag ctgaaacgta cggtggctgc accatctgtc      420

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      480

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      540

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      600

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      660

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         717


<210>  21
<211>  1401
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "mAb 0051 HC"

<400>  21
atgggttgga gctgtatcat cttctttctg gtagcaacag ctacaggtgt gcactcccag       60

gtccagctgg agcagtctgg ggctgagctg gtgaggcctg gggtctcagt gaagatttcc      120

tgcaagggtt ctggctacac attcactgat tattctatgc actgggtgaa gcagagtcat      180

gcaaagagtc tagagtggat tggagttatt agtacttact atggtgatgt taggtacaac      240

cagaagttca agggcaaggc cacaatgact gtagacaaat cctccagcac agcctatatg      300

gcacttgcca gactgacatc tgaggattct gccatctatt actgtgcaag agcccctatg      360

attacgacag gggcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      420

gctagcacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag      480

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      540

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      660

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      720

aaatatggtc ccccatgccc accatgccca gcacctgagt tcctgggggg accatcagtc      780

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      840

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      900

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      960

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag     1020

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa     1080

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag     1140

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag     1200

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc     1260

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg     1320

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc     1380

ctctccctgt ctctgggtaa a                                               1401


<210>  22
<211>  702
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "mAb 0051 LC"

<400>  22
atgaagtcac agacccaggt cttcgtattt ctactgctct gtgtgtctgg tgctcatggg       60

agtattgtga tgacccagac tcccaaattc ctgcttgtat cagcaggaga cagggttacc      120

ataacctgca aggccagtca gagtgtgagt aatgatgtag cttggtacca acagaagcca      180

gggcagtctc ctaaactgct gataaactat gcatccagtc gctacactgg aatccctgat      240

cgcttcactg gcagtggata tgggacggat ttcactttca ccatcagcac tgtgcaggct      300

gaagacctgg cagtttattt ctgtcagcag gattatagct ctccgtacac gttcggaggg      360

gggaccaagc tggaaataga acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         702


<210>  23
<211>  1404
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "mAb 0052 HC"

<400>  23
atggaatgga cctgggtctt tctcttcctc ctgtcagtaa ctgcaggtgt ccattcccag       60

gtccagctgc agcagtctgg agctgagccg atgaagcctg gggcctcagt gaagatatcc      120

tgcaaggcta ctggctacac atttagtagt cactggatag agtggataaa acagaggcct      180

ggacatggcc ttgagtggat tggagagatt ttacctggaa gtggaaatac taattacaat      240

gagaaattca agggcaaggc cacattcact gcagatacat cctccaacac agcctacatg      300

caactcagca gcctgacatc tgaggactct gccgtctatt gctgtgcaag agggtactac      360

ggtcttaact acgactggta tttcgatgtc tggggcgcag ggaccacggt caccgtctcc      420

tcagctagca ccaagggccc atccgtcttc cccctggcgc cctgctccag gagcacctcc      480

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacgaag      660

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gagagttgag      720

tccaaatatg gtcccccatg cccaccatgc ccagcacctg agttcctggg gggaccatca      780

gtcttcctgt tccccccaaa acccaaggac actctcatga tctcccggac ccctgaggtc      840

acgtgcgtgg tggtggacgt gagccaggaa gaccccgagg tccagttcaa ctggtacgtg      900

gatggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagtt caacagcacg      960

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaacgg caaggagtac     1020

aagtgcaagg tctccaacaa aggcctcccg tcctccatcg agaaaaccat ctccaaagcc     1080

aaagggcagc cccgagagcc acaggtgtac accctgcccc catcccagga ggagatgacc     1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg     1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1260

tccgacggct ccttcttcct ctacagcagg ctaaccgtgg acaagagcag gtggcaggag     1320

gggaatgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacacagaag     1380

agcctctccc tgtctctggg taaa                                            1404


<210>  24
<211>  1404
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "mAb 0062 HC"

<400>  24
atggaatgga cctgggtctt tctcttcctc ctgtcagtaa ctgcaggtgt ccattcccag       60

gtccagctgc agcagtctgg agctgagccg atgaagcctg gggcctcagt gaagatatcc      120

tgcaaggcta ctggctacac atttagtagt cactggatag agtggataaa acagaggcct      180

ggacatggcc ttgagtggat tggagagatt ttacctggaa gtggaaatac taattacaat      240

gagaaattca agggcaaggc cacattcact gcagatacat cctccaacac agcctacatg      300

caactcagca gcctgacatc tgaggactct gccgtctatt actgtgcaag agggtactac      360

ggtcttaact acgactggta tttcgatgtc tggggcgcag ggaccacggt caccgtctcc      420

tcagctagca ccaagggccc atccgtcttc cccctggcgc cctgctccag gagcacctcc      480

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacgaag      660

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gagagttgag      720

tccaaatatg gtcccccatg cccaccatgc ccagcacctg agttcctggg gggaccatca      780

gtcttcctgt tccccccaaa acccaaggac actctcatga tctcccggac ccctgaggtc      840

acgtgcgtgg tggtggacgt gagccaggaa gaccccgagg tccagttcaa ctggtacgtg      900

gatggcgtgg aggtgcataa tgccaagaca aagccgcggg aggagcagtt caacagcacg      960

taccgtgtgg tcagcgtcct caccgtcctg caccaggact ggctgaacgg caaggagtac     1020

aagtgcaagg tctccaacaa aggcctcccg tcctccatcg agaaaaccat ctccaaagcc     1080

aaagggcagc cccgagagcc acaggtgtac accctgcccc catcccagga ggagatgacc     1140

aagaaccagg tcagcctgac ctgcctggtc aaaggcttct accccagcga catcgccgtg     1200

gagtgggaga gcaatgggca gccggagaac aactacaaga ccacgcctcc cgtgctggac     1260

tccgacggct ccttcttcct ctacagcagg ctaaccgtgg acaagagcag gtggcaggag     1320

gggaatgtct tctcatgctc cgtgatgcat gaggctctgc acaaccacta cacacagaag     1380

agcctctccc tgtctctggg taaa                                            1404


<210>  25
<211>  702
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "mAb 0052 LC, mAb 0062 LC"

<400>  25
atgatgtcct ctgctcagtt ccttggtctc ctgttgctct gttttcaagg taccagatgt       60

gatatccaga tgacacagac tacatcctcc ctgtctgcct ctctgggaga cagagtcacc      120

attagttgca gggcaagtca ggacattagc aattatttaa actggtatca gcagaaacca      180

gatggaactg ttaaactcct tatcttctac acatcaagat tacactcagg agtcccgtca      240

aggttcagtg gcagtgggtc tgggacagat tattctctca ccattagcaa cctggaaccg      300

gaagatattg ccacttacta ttgccaacag gatactaagc ttccgtacac gttcggaggg      360

gggaccaaac tggagatgaa acgtacggtg gctgcaccat ctgtcttcat cttcccgcca      420

tctgatgagc agttgaaatc tggaactgcc tctgttgtgt gcctgctgaa taacttctat      480

cccagagagg ccaaagtaca gtggaaggtg gataacgccc tccaatcggg taactcccag      540

gagagtgtca cagagcagga cagcaaggac agcacctaca gcctcagcag caccctgacg      600

ctgagcaaag cagactacga gaaacacaaa gtctacgcct gcgaagtcac ccatcagggc      660

ctgagctcgc ccgtcacaaa gagcttcaac aggggagagt gt                         702


<210>  26
<211>  1377
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "mAb 0061 HC"

<400>  26
atggattttg ggctgatttt ttttattgtt gctcttttaa aaggggtcca gtgtgaggtg       60

aaacttctcg agtctggagg tggcctggtg cagcctggag gatccctgaa actctcctgt      120

gcagcctcag gattcgattt tagtagatac tggatgactt gggtccggca ggctccaggg      180

aaagggctag aatggattgg agaaattaat ccagatagca gtacgataaa ctataaccca      240

tctctaaagg ataaattcat catctccaga gacaacgcca agaatacgct gtacctgcaa      300

atgagcgaag tgagatctga ggacacagcc ctttattact gtgcaagcgg ggtgtttact      360

tcctggggcc aagggactct ggtcactgtc tctgcagcta gcaccaaggg cccatccgtc      420

ttccccctgg cgccctgctc caggagcacc tccgagagca cagccgccct gggctgcctg      480

gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc cctgaccagc      540

ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct cagcagcgtg      600

gtgaccgtgc cctccagcag cttgggcacg aagacctaca cctgcaacgt agatcacaag      660

cccagcaaca ccaaggtgga caagagagtt gagtccaaat atggtccccc atgcccacca      720

tgcccagcac ctgagttcct ggggggacca tcagtcttcc tgttcccccc aaaacccaag      780

gacactctca tgatctcccg gacccctgag gtcacgtgcg tggtggtgga cgtgagccag      840

gaagaccccg aggtccagtt caactggtac gtggatggcg tggaggtgca taatgccaag      900

acaaagccgc gggaggagca gttcaacagc acgtaccgtg tggtcagcgt cctcaccgtc      960

ctgcaccagg actggctgaa cggcaaggag tacaagtgca aggtctccaa caaaggcctc     1020

ccgtcctcca tcgagaaaac catctccaaa gccaaagggc agccccgaga gccacaggtg     1080

tacaccctgc ccccatccca ggaggagatg accaagaacc aggtcagcct gacctgcctg     1140

gtcaaaggct tctaccccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1200

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1260

aggctaaccg tggacaagag caggtggcag gaggggaatg tcttctcatg ctccgtgatg     1320

catgaggctc tgcacaacca ctacacacag aagagcctct ccctgtctct gggtaaa        1377


<210>  27
<211>  1377
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "mAb 0082 HC"

<400>  27
atggattttg ggctgatttt ttttattgtt gctcttttaa aaggggtcca gtgtgaggtg       60

aaacttctcg agtctggagg tggcctggtg cagcctggag gatccctgaa actctcctgt      120

gcagcctcag gattcgattt tagtagatac tggatgactt gggtccggca ggctccaggg      180

aaagggctag aatggattgg agaaattaat ccagatagca gtacgataaa ctatgcgcca      240

tctctaaagg ataaattcat catctccaga gacaacgcca agaatacgct gtacctgcaa      300

atgagcgaag tgagatctga ggacacagcc ctttattact gtgcaagcgg ggtgtttact      360

tcctggggcc aagggactct ggtcactgtc tctgcagcta gcaccaaggg cccatccgtc      420

ttccccctgg cgccctgctc caggagcacc tccgagagca cagccgccct gggctgcctg      480

gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc cctgaccagc      540

ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct cagcagcgtg      600

gtgaccgtgc cctccagcag cttgggcacg aagacctaca cctgcaacgt agatcacaag      660

cccagcaaca ccaaggtgga caagagagtt gagtccaaat atggtccccc atgcccacca      720

tgcccagcac ctgagttcct ggggggacca tcagtcttcc tgttcccccc aaaacccaag      780

gacactctca tgatctcccg gacccctgag gtcacgtgcg tggtggtgga cgtgagccag      840

gaagaccccg aggtccagtt caactggtac gtggatggcg tggaggtgca taatgccaag      900

acaaagccgc gggaggagca gttcaacagc acgtaccgtg tggtcagcgt cctcaccgtc      960

ctgcaccagg actggctgaa cggcaaggag tacaagtgca aggtctccaa caaaggcctc     1020

ccgtcctcca tcgagaaaac catctccaaa gccaaagggc agccccgaga gccacaggtg     1080

tacaccctgc ccccatccca ggaggagatg accaagaacc aggtcagcct gacctgcctg     1140

gtcaaaggct tctaccccag cgacatcgcc gtggagtggg agagcaatgg gcagccggag     1200

aacaactaca agaccacgcc tcccgtgctg gactccgacg gctccttctt cctctacagc     1260

aggctaaccg tggacaagag caggtggcag gaggggaatg tcttctcatg ctccgtgatg     1320

catgaggctc tgcacaacca ctacacacag aagagcctct ccctgtctct gggtaaa        1377


<210>  28
<211>  714
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "mAb 0061 LC, Fab 0061 LC, mAb 0082 LC, Fab 0082 LC"

<400>  28
atgaagttgc ctgttgggct gttggtgctg atgttctgga ttccagcttc cagcagtgat       60

gttgtgatga cccaaactcc actctccctg cctgtcagtc ttggagatca agcctccatc      120

tcttgcagat ctagtcagag ccttgtacac agaaatggaa acacctattt tcattgggcc      180

ctgcagaaac caggccagtc tccaaagctc ctgatctaca aagtttccaa ccgattttct      240

ggggtcccag acaggttcag tggcagtgga tcagggacag atttcacact caagatcagc      300

agagtggagg ctgaggatct gggagtttat ttctgctctc aaagtacaca tgttccgtac      360

acgttcggag gggggaccaa gctggaaata aaacgtacgg tggctgcacc atctgtcttc      420

atcttcccgc catctgatga gcagttgaaa tctggaactg cctctgttgt gtgcctgctg      480

aataacttct atcccagaga ggccaaagta cagtggaagg tggataacgc cctccaatcg      540

ggtaactccc aggagagtgt cacagagcag gacagcaagg acagcaccta cagcctcagc      600

agcaccctga cgctgagcaa agcagactac gagaaacaca aagtctacgc ctgcgaagtc      660

acccatcagg gcctgagctc gcccgtcaca aagagcttca acaggggaga gtgt            714


<210>  29
<211>  699
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "Fab 0012 VH-CH1"

<400>  29
atggattttg ggctgatttt ttttattgtt gctcttttaa aaggggtcca gtgtgaggtg       60

aaacttctcg agtctggagg tggcctggtg cagcctggag gatccctgaa actctcctgt      120

gcagcctcag gattcgattt tagtagatac tggatgactt gggtccggca ggctccaggg      180

aaagggctag aatggattgg agaaattaat ccagatagca gtacgataaa ctatacgcca      240

tctctaaagg ataaattcat catctccaga gacaacgcca agaatacgct gtacctgcaa      300

atgagcgaag tgagatctga ggacacagcc ctttattact gtgcaagcgg ggtgtttact      360

tcctggggcc aagggactct ggtcactgtc tctgcagcta gcaccaaggg cccatccgtc      420

ttccccctgg cgccctgctc caggagcacc tccgagagca cagccgccct gggctgcctg      480

gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc cctgaccagc      540

ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct cagcagcgtg      600

gtgaccgtgc cctccagcag cttgggcacg aagacctaca cctgcaacgt agatcacaag      660

cccagcaaca ccaaggtgga caagagagtt gagtccaaa                             699


<210>  30
<211>  723
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "Fab 0023 VH-CH1"

<400>  30
atgaacttgg ggctcagctt gattttcctt gtccttgttt taaaaggtgt ccagtgtgaa       60

gtgaggctgg tggagtctgg gggaggctta gtgcagcctg gagggtccct gaaactctcc      120

tgtgcaacct ctggattcac tttcagtgac tatttcatgt attggattcg ccagactcca      180

gagaagaggc tggagtgggt cgcatacatt agtaatggtg gtgatagcag ctcttatcca      240

gacactgtaa agggccgatt caccatctcc agagacaatg ccaagaacac cctgtacctg      300

caaatgagcc gtctgaagtc tgaggacaca gccatgtatt attgtgcaac aaataaaaac      360

tgggacgatt actatgatat ggactactgg ggtcaaggaa cctcagtcac cgtctcctca      420

gctagcacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag      480

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      540

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      660

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      720

aaa                                                                    723


<210>  31
<211>  723
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "Fab 0051 VH-CH1"

<400>  31
atgggttgga gctgtatcat cttctttctg gtagcaacag ctacaggtgt gcactcccag       60

gtccagctgg agcagtctgg ggctgagctg gtgaggcctg gggtctcagt gaagatttcc      120

tgcaagggtt ctggctacac attcactgat tattctatgc actgggtgaa gcagagtcat      180

gcaaagagtc tagagtggat tggagttatt agtacttact atggtgatgt taggtacaac      240

cagaagttca agggcaaggc cacaatgact gtagacaaat cctccagcac agcctatatg      300

gcacttgcca gactgacatc tgaggattct gccatctatt actgtgcaag agcccctatg      360

attacgacag gggcctggtt tgcttactgg ggccaaggga ctctggtcac tgtctctgca      420

gctagcacca agggcccatc cgtcttcccc ctggcgccct gctccaggag cacctccgag      480

agcacagccg ccctgggctg cctggtcaag gactacttcc ccgaaccggt gacggtgtcg      540

tggaactcag gcgccctgac cagcggcgtg cacaccttcc cggctgtcct acagtcctca      600

ggactctact ccctcagcag cgtggtgacc gtgccctcca gcagcttggg cacgaagacc      660

tacacctgca acgtagatca caagcccagc aacaccaagg tggacaagag agttgagtcc      720

aaa                                                                    723


<210>  32
<211>  726
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "Fab 0052 VH-CH1"

<400>  32
atggaatgga cctgggtctt tctcttcctc ctgtcagtaa ctgcaggtgt ccattcccag       60

gtccagctgc agcagtctgg agctgagccg atgaagcctg gggcctcagt gaagatatcc      120

tgcaaggcta ctggctacac atttagtagt cactggatag agtggataaa acagaggcct      180

ggacatggcc ttgagtggat tggagagatt ttacctggaa gtggaaatac taattacaat      240

gagaaattca agggcaaggc cacattcact gcagatacat cctccaacac agcctacatg      300

caactcagca gcctgacatc tgaggactct gccgtctatt gctgtgcaag agggtactac      360

ggtcttaact acgactggta tttcgatgtc tggggcgcag ggaccacggt caccgtctcc      420

tcagctagca ccaagggccc atccgtcttc cccctggcgc cctgctccag gagcacctcc      480

gagagcacag ccgccctggg ctgcctggtc aaggactact tccccgaacc ggtgacggtg      540

tcgtggaact caggcgccct gaccagcggc gtgcacacct tcccggctgt cctacagtcc      600

tcaggactct actccctcag cagcgtggtg accgtgccct ccagcagctt gggcacgaag      660

acctacacct gcaacgtaga tcacaagccc agcaacacca aggtggacaa gagagttgag      720

tccaaa                                                                 726


<210>  33
<211>  699
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "Fab 0061 VH-CH1"

<400>  33
atggattttg ggctgatttt ttttattgtt gctcttttaa aaggggtcca gtgtgaggtg       60

aaacttctcg agtctggagg tggcctggtg cagcctggag gatccctgaa actctcctgt      120

gcagcctcag gattcgattt tagtagatac tggatgactt gggtccggca ggctccaggg      180

aaagggctag aatggattgg agaaattaat ccagatagca gtacgataaa ctataaccca      240

tctctaaagg ataaattcat catctccaga gacaacgcca agaatacgct gtacctgcaa      300

atgagcgaag tgagatctga ggacacagcc ctttattact gtgcaagcgg ggtgtttact      360

tcctggggcc aagggactct ggtcactgtc tctgcagcta gcaccaaggg cccatccgtc      420

ttccccctgg cgccctgctc caggagcacc tccgagagca cagccgccct gggctgcctg      480

gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc cctgaccagc      540

ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct cagcagcgtg      600

gtgaccgtgc cctccagcag cttgggcacg aagacctaca cctgcaacgt agatcacaag      660

cccagcaaca ccaaggtgga caagagagtt gagtccaaa                             699


<210>  34
<211>  699
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "Fab 0082 VH-CH1"

<400>  34
atggattttg ggctgatttt ttttattgtt gctcttttaa aaggggtcca gtgtgaggtg       60

aaacttctcg agtctggagg tggcctggtg cagcctggag gatccctgaa actctcctgt      120

gcagcctcag gattcgattt tagtagatac tggatgactt gggtccggca ggctccaggg      180

aaagggctag aatggattgg agaaattaat ccagatagca gtacgataaa ctatgcgcca      240

tctctaaagg ataaattcat catctccaga gacaacgcca agaatacgct gtacctgcaa      300

atgagcgaag tgagatctga ggacacagcc ctttattact gtgcaagcgg ggtgtttact      360

tcctggggcc aagggactct ggtcactgtc tctgcagcta gcaccaaggg cccatccgtc      420

ttccccctgg cgccctgctc caggagcacc tccgagagca cagccgccct gggctgcctg      480

gtcaaggact acttccccga accggtgacg gtgtcgtgga actcaggcgc cctgaccagc      540

ggcgtgcaca ccttcccggc tgtcctacag tcctcaggac tctactccct cagcagcgtg      600

gtgaccgtgc cctccagcag cttgggcacg aagacctaca cctgcaacgt agatcacaag      660

cccagcaaca ccaaggtgga caagagagtt gagtccaaa                             699


<210>  35
<211>  720
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "Fab AP-3 VH-VH1"

<400>  35
atggaatgga gcggggtctt tatctttctc ttgtcagtaa ctgcagatgt ccactcccag       60

gtccagttgc agcagtctgg agctgagctg gtaaggcctg ggacttcagt gaagatatcc      120

tgcaaggctt ctggctacac cttcactaac tactggctag gttgggtaaa gcagaggcct      180

ggacatggac ttgagtggat tggagatatt taccctggag gtggttataa taagtacaat      240

gagaatttca agggcaaggc cacactgact gcagacacat cctccagcac tgcctacatg      300

cagctcagta gcctgacatc tgaggactct gctgtctatt tctgtgcaag agagtatggt      360

aactacgact atgctatgga ctcctggggt caaggaacct cagtcaccgt ctcctcagct      420

agcaccaagg gcccatccgt cttccccctg gcgccctgct ccaggagcac ctccgagagc      480

acagccgccc tgggctgcct ggtcaaggac tacttccccg aaccggtgac ggtgtcgtgg      540

aactcaggcg ccctgaccag cggcgtgcac accttcccgg ctgtcctaca gtcctcagga      600

ctctactccc tcagcagcgt ggtgaccgtg ccctccagca gcttgggcac gaagacctac      660

acctgcaacg tagatcacaa gcccagcaac accaaggtgg acaagagagt tgagtccaaa      720


<210>  36
<211>  717
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "Fab AP-3 LC"

<400>  36
atgaggtgcc tagctgagtt cctggggctg cttgtgctct ggatccctgg agccattggg       60

gatattgtga tgactcaggc tgcaccctct gtacctgtca ctcctggaga gtcagtatcc      120

atctcctgca ggtctagtag gagtctcctg catagtaatg gcaacactta cttgtgttgg      180

ttcctgcaga ggccaggcca gtctcctcag ctcctgatat atcggatgtc caaccttgcc      240

tcaggagtcc cagacaggtt cagtggcagt gggtcaggaa ctgctttcac actgagaatc      300

agtagagtgg aggctgagga tgtgggtgtt tattactgta tgcaacatct agaatatcca      360

ttcacgttcg gctcggggac aaagttggaa ataaaacgta cggtggctgc accatctgtc      420

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      480

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      540

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      600

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      660

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         717


<210>  37
<211>  717
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "Fab-AP-3 LC.C34S"

<400>  37
atgaggtgcc tagctgagtt cctggggctg cttgtgctct ggatccctgg agccattggg       60

gatattgtga tgactcaggc tgcaccctct gtacctgtca ctcctggaga gtcagtatcc      120

atctcctgca ggtctagtag gagtctcctg catagtaatg gcaacactta cttgtcctgg      180

ttcctgcaga ggccaggcca gtctcctcag ctcctgatat atcggatgtc caaccttgcc      240

tcaggagtcc cagacaggtt cagtggcagt gggtcaggaa ctgctttcac actgagaatc      300

agtagagtgg aggctgagga tgtgggtgtt tattactgta tgcaacatct agaatatcca      360

ttcacgttcg gctcggggac aaagttggaa ataaaacgta cggtggctgc accatctgtc      420

ttcatcttcc cgccatctga tgagcagttg aaatctggaa ctgcctctgt tgtgtgcctg      480

ctgaataact tctatcccag agaggccaaa gtacagtgga aggtggataa cgccctccaa      540

tcgggtaact cccaggagag tgtcacagag caggacagca aggacagcac ctacagcctc      600

agcagcaccc tgacgctgag caaagcagac tacgagaaac acaaagtcta cgcctgcgaa      660

gtcacccatc agggcctgag ctcgcccgtc acaaagagct tcaacagggg agagtgt         717


<210>  38
<211>  741
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "hIgG4 hinge-CH2-CH3"

<400>  38
atggattttg ggctgatttt ttttattgtt gctcttttaa aaggggtcca gtgtgagtcc       60

aaatatggtc ccccatgccc accatgccca gcacctgagt tcctgggggg accatcagtc      120

ttcctgttcc ccccaaaacc caaggacact ctcatgatct cccggacccc tgaggtcacg      180

tgcgtggtgg tggacgtgag ccaggaagac cccgaggtcc agttcaactg gtacgtggat      240

ggcgtggagg tgcataatgc caagacaaag ccgcgggagg agcagttcaa cagcacgtac      300

cgtgtggtca gcgtcctcac cgtcctgcac caggactggc tgaacggcaa ggagtacaag      360

tgcaaggtct ccaacaaagg cctcccgtcc tccatcgaga aaaccatctc caaagccaaa      420

gggcagcccc gagagccaca ggtgtacacc ctgcccccat cccaggagga gatgaccaag      480

aaccaggtca gcctgacctg cctggtcaaa ggcttctacc ccagcgacat cgccgtggag      540

tgggagagca atgggcagcc ggagaacaac tacaagacca cgcctcccgt gctggactcc      600

gacggctcct tcttcctcta cagcaggcta accgtggaca agagcaggtg gcaggagggg      660

aatgtcttct catgctccgt gatgcatgag gctctgcaca accactacac acagaagagc      720

ctctccctgt ctctgggtaa a                                                741


<210>  39
<211>  459
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "mAb 0012, HC (mouse VH-human IgG4 CH1-CH2-CH3)"

<400>  39

Met Asp Phe Gly Leu Ile Phe Phe Ile Val Ala Leu Leu Lys Gly Val 
1               5                   10                  15      


Gln Cys Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser 
        35                  40                  45              


Arg Tyr Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Pro 
65                  70                  75                  80  


Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr 
                85                  90                  95      


Leu Tyr Leu Gln Met Ser Glu Val Arg Ser Glu Asp Thr Ala Leu Tyr 
            100                 105                 110         


Tyr Cys Ala Ser Gly Val Phe Thr Ser Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
        355                 360                 365             


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    450                 455                 


<210>  40
<211>  238
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "mAb 0012, LC (mouse VL - human Kappa CL); Fab 0012, LC 
       (mouse VL - human Kappa CL)"

<400>  40

Met Lys Leu Pro Val Gly Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Val His Arg Asn Gly Asn Thr Tyr Phe His Trp Cys Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            100                 105                 110         


Ser Gln Ser Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             


<210>  41
<211>  467
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "mAb 0023, HC (mouse VH-human IgG4 CH1-CH2-CH3)"

<400>  41

Met Asn Leu Gly Leu Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Arg Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Tyr Phe Met Tyr Trp Ile Arg Gln Thr Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Tyr Ile Ser Asn Gly Gly Asp Ser Ser Ser Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Arg Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Thr Asn Lys Asn Trp Asp Asp Tyr Tyr Asp Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
225                 230                 235                 240 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Leu Gly Lys 
465         


<210>  42
<211>  239
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "mAb 0023, LC (mouse VL - human Kappa CL); Fab 0023, LC 
       (mouse VL - human Kappa CL)"

<400>  42

Met Asp Ser Gln Ala Gln Val Leu Ile Leu Leu Leu Leu Trp Val Ser 
1               5                   10                  15      


Gly Ser Cys Gly Asp Ile Val Val Ser Gln Ser Pro Ser Ser Leu Ala 
            20                  25                  30          


Val Ser Ala Gly Glu Lys Val Thr Met Ser Cys Lys Ser Ser Gln Ser 
        35                  40                  45              


Leu Leu Asn Ser Arg Thr Arg Lys Asn Tyr Leu Ala Trp Tyr Gln Gln 
    50                  55                  60                  


Lys Pro Gly Gln Ser Pro Lys Leu Leu Ile Tyr Trp Ala Ser Thr Arg 
65                  70                  75                  80  


Glu Ser Gly Val Pro Asp Arg Phe Thr Gly Ser Gly Ser Gly Thr Asp 
                85                  90                  95      


Phe Thr Leu Thr Ile Ser Ser Val Gln Ala Glu Asp Leu Ala Val Tyr 
            100                 105                 110         


Tyr Cys Lys Gln Ser Tyr Asn Leu Leu Thr Phe Gly Ala Gly Thr Lys 
        115                 120                 125             


Leu Glu Leu Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  43
<211>  467
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "mAb 0051, HC (mouse VH-human IgG4 CH1-CH2-CH3)"

<400>  43

Met Gly Trp Ser Cys Ile Ile Phe Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Glu Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Ser Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Ser Thr Tyr Tyr Gly Asp Val Arg Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Ala Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Pro Met Ile Thr Thr Gly Ala Trp Phe Ala 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
225                 230                 235                 240 


Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu Gly 
                245                 250                 255     


Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met 
            260                 265                 270         


Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser Gln 
        275                 280                 285             


Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val 
    290                 295                 300                 


His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Tyr 
305                 310                 315                 320 


Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn Gly 
                325                 330                 335     


Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser Ile 
            340                 345                 350         


Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln Val 
        355                 360                 365             


Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val Ser 
    370                 375                 380                 


Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu 
385                 390                 395                 400 


Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro 
                405                 410                 415     


Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr Val 
            420                 425                 430         


Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val Met 
        435                 440                 445             


His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser 
    450                 455                 460                 


Leu Gly Lys 
465         


<210>  44
<211>  234
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "mAb 0051, LC (mouse VL - human Kappa CL); Fab 0051, LC 
       (mouse VL - human Kappa CL)"

<400>  44

Met Lys Ser Gln Thr Gln Val Phe Val Phe Leu Leu Leu Cys Val Ser 
1               5                   10                  15      


Gly Ala His Gly Ser Ile Val Met Thr Gln Thr Pro Lys Phe Leu Leu 
            20                  25                  30          


Val Ser Ala Gly Asp Arg Val Thr Ile Thr Cys Lys Ala Ser Gln Ser 
        35                  40                  45              


Val Ser Asn Asp Val Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro 
    50                  55                  60                  


Lys Leu Leu Ile Asn Tyr Ala Ser Ser Arg Tyr Thr Gly Ile Pro Asp 
65                  70                  75                  80  


Arg Phe Thr Gly Ser Gly Tyr Gly Thr Asp Phe Thr Phe Thr Ile Ser 
                85                  90                  95      


Thr Val Gln Ala Glu Asp Leu Ala Val Tyr Phe Cys Gln Gln Asp Tyr 
            100                 105                 110         


Ser Ser Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Glu Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  45
<211>  468
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "mAb 0052, HC (mouse VH-human IgG4 CH1-CH2-CH3)"

<400>  45

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Pro Met Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe 
        35                  40                  45              


Ser Ser His Trp Ile Glu Trp Ile Lys Gln Arg Pro Gly His Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Leu Pro Gly Ser Gly Asn Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Cys Cys Ala Arg Gly Tyr Tyr Gly Leu Asn Tyr Asp Trp Tyr Phe 
        115                 120                 125             


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Leu Gly Lys 
465             


<210>  46
<211>  234
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "mAb 0052, LC (mouse VL - human Kappa CL); mAb 0062, LC 
       (mouse VL - human Kappa CL); Fab 0052, LC (mouse VL - human Kappa
       CL)"

<400>  46

Met Met Ser Ser Ala Gln Phe Leu Gly Leu Leu Leu Leu Cys Phe Gln 
1               5                   10                  15      


Gly Thr Arg Cys Asp Ile Gln Met Thr Gln Thr Thr Ser Ser Leu Ser 
            20                  25                  30          


Ala Ser Leu Gly Asp Arg Val Thr Ile Ser Cys Arg Ala Ser Gln Asp 
        35                  40                  45              


Ile Ser Asn Tyr Leu Asn Trp Tyr Gln Gln Lys Pro Asp Gly Thr Val 
    50                  55                  60                  


Lys Leu Leu Ile Phe Tyr Thr Ser Arg Leu His Ser Gly Val Pro Ser 
65                  70                  75                  80  


Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Tyr Ser Leu Thr Ile Ser 
                85                  90                  95      


Asn Leu Glu Pro Glu Asp Ile Ala Thr Tyr Tyr Cys Gln Gln Asp Thr 
            100                 105                 110         


Lys Leu Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Met Lys Arg 
        115                 120                 125             


Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu Gln 
    130                 135                 140                 


Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe Tyr 
145                 150                 155                 160 


Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln Ser 
                165                 170                 175     


Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser Thr 
            180                 185                 190         


Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu Lys 
        195                 200                 205             


His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser Pro 
    210                 215                 220                 


Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 


<210>  47
<211>  459
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "mAb 0061, HC (mouse VH-human IgG4 CH1-CH2-CH3)"

<400>  47

Met Asp Phe Gly Leu Ile Phe Phe Ile Val Ala Leu Leu Lys Gly Val 
1               5                   10                  15      


Gln Cys Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser 
        35                  40                  45              


Arg Tyr Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr 
                85                  90                  95      


Leu Tyr Leu Gln Met Ser Glu Val Arg Ser Glu Asp Thr Ala Leu Tyr 
            100                 105                 110         


Tyr Cys Ala Ser Gly Val Phe Thr Ser Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
        355                 360                 365             


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    450                 455                 


<210>  48
<211>  238
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "mAb 0061, LC (mouse VL - human Kappa CL); Fab 0061, LC 
       (mouse VL - human Kappa CL); mAb 0082, LC (mouse VL - human Kappa
       CL); Fab 0082, LC (mouse VL - human Kappa CL)"

<400>  48

Met Lys Leu Pro Val Gly Leu Leu Val Leu Met Phe Trp Ile Pro Ala 
1               5                   10                  15      


Ser Ser Ser Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val 
            20                  25                  30          


Ser Leu Gly Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu 
        35                  40                  45              


Val His Arg Asn Gly Asn Thr Tyr Phe His Trp Ala Leu Gln Lys Pro 
    50                  55                  60                  


Gly Gln Ser Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser 
65                  70                  75                  80  


Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr 
                85                  90                  95      


Leu Lys Ile Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys 
            100                 105                 110         


Ser Gln Ser Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu 
        115                 120                 125             


Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro 
    130                 135                 140                 


Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu 
145                 150                 155                 160 


Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn 
                165                 170                 175     


Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser 
            180                 185                 190         


Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala 
        195                 200                 205             


Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly 
    210                 215                 220                 


Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235             


<210>  49
<211>  468
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "mAb 0062, HC (mouse VH-human IgG4 CH1-CH2-CH3)"

<400>  49

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Pro Met Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe 
        35                  40                  45              


Ser Ser His Trp Ile Glu Trp Ile Lys Gln Arg Pro Gly His Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Leu Pro Gly Ser Gly Asn Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Gly Tyr Tyr Gly Leu Asn Tyr Asp Trp Tyr Phe 
        115                 120                 125             


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro Glu Phe Leu 
                245                 250                 255     


Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu 
            260                 265                 270         


Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser 
        275                 280                 285             


Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu 
    290                 295                 300                 


Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr 
305                 310                 315                 320 


Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp Trp Leu Asn 
                325                 330                 335     


Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ser Ser 
            340                 345                 350         


Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg Glu Pro Gln 
        355                 360                 365             


Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys Asn Gln Val 
    370                 375                 380                 


Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val 
385                 390                 395                 400 


Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro 
                405                 410                 415     


Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Arg Leu Thr 
            420                 425                 430         


Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser Cys Ser Val 
        435                 440                 445             


Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu 
    450                 455                 460                 


Ser Leu Gly Lys 
465             


<210>  50
<211>  459
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "mAb 0082, HC (mouse VH-human IgG4 CH1-CH2-CH3)"

<400>  50

Met Asp Phe Gly Leu Ile Phe Phe Ile Val Ala Leu Leu Lys Gly Val 
1               5                   10                  15      


Gln Cys Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser 
        35                  40                  45              


Arg Tyr Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro 
65                  70                  75                  80  


Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr 
                85                  90                  95      


Leu Tyr Leu Gln Met Ser Glu Val Arg Ser Glu Asp Thr Ala Leu Tyr 
            100                 105                 110         


Tyr Cys Ala Ser Gly Val Phe Thr Ser Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro 
225                 230                 235                 240 


Cys Pro Ala Pro Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro 
                245                 250                 255     


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
            260                 265                 270         


Cys Val Val Val Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn 
        275                 280                 285             


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
    290                 295                 300                 


Glu Glu Gln Phe Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val 
305                 310                 315                 320 


Leu His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
                325                 330                 335     


Asn Lys Gly Leu Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys 
            340                 345                 350         


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu 
        355                 360                 365             


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
    370                 375                 380                 


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
385                 390                 395                 400 


Asn Asn Tyr Lys Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe 
                405                 410                 415     


Phe Leu Tyr Ser Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly 
            420                 425                 430         


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
        435                 440                 445             


Thr Gln Lys Ser Leu Ser Leu Ser Leu Gly Lys 
    450                 455                 


<210>  51
<211>  233
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "Fab 0012, mouse VH - human IgG4 CH1"

<400>  51

Met Asp Phe Gly Leu Ile Phe Phe Ile Val Ala Leu Leu Lys Gly Val 
1               5                   10                  15      


Gln Cys Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser 
        35                  40                  45              


Arg Tyr Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Thr Pro 
65                  70                  75                  80  


Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr 
                85                  90                  95      


Leu Tyr Leu Gln Met Ser Glu Val Arg Ser Glu Asp Thr Ala Leu Tyr 
            100                 105                 110         


Tyr Cys Ala Ser Gly Val Phe Thr Ser Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Ser Lys 
225                 230             


<210>  52
<211>  241
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "Fab 0023, mouse VH - human IgG4 CH1"

<400>  52

Met Asn Leu Gly Leu Ser Leu Ile Phe Leu Val Leu Val Leu Lys Gly 
1               5                   10                  15      


Val Gln Cys Glu Val Arg Leu Val Glu Ser Gly Gly Gly Leu Val Gln 
            20                  25                  30          


Pro Gly Gly Ser Leu Lys Leu Ser Cys Ala Thr Ser Gly Phe Thr Phe 
        35                  40                  45              


Ser Asp Tyr Phe Met Tyr Trp Ile Arg Gln Thr Pro Glu Lys Arg Leu 
    50                  55                  60                  


Glu Trp Val Ala Tyr Ile Ser Asn Gly Gly Asp Ser Ser Ser Tyr Pro 
65                  70                  75                  80  


Asp Thr Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ala Lys Asn 
                85                  90                  95      


Thr Leu Tyr Leu Gln Met Ser Arg Leu Lys Ser Glu Asp Thr Ala Met 
            100                 105                 110         


Tyr Tyr Cys Ala Thr Asn Lys Asn Trp Asp Asp Tyr Tyr Asp Met Asp 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
225                 230                 235                 240 


Lys 
    


<210>  53
<211>  241
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "Fab 0051, mouse VH - human IgG4 CH1"

<400>  53

Met Gly Trp Ser Cys Ile Ile Phe Phe Leu Val Ala Thr Ala Thr Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Glu Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Val Ser Val Lys Ile Ser Cys Lys Gly Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asp Tyr Ser Met His Trp Val Lys Gln Ser His Ala Lys Ser Leu 
    50                  55                  60                  


Glu Trp Ile Gly Val Ile Ser Thr Tyr Tyr Gly Asp Val Arg Tyr Asn 
65                  70                  75                  80  


Gln Lys Phe Lys Gly Lys Ala Thr Met Thr Val Asp Lys Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Ala Leu Ala Arg Leu Thr Ser Glu Asp Ser Ala Ile 
            100                 105                 110         


Tyr Tyr Cys Ala Arg Ala Pro Met Ile Thr Thr Gly Ala Trp Phe Ala 
        115                 120                 125             


Tyr Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ala Ala Ser Thr Lys 
    130                 135                 140                 


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
145                 150                 155                 160 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
                165                 170                 175     


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
            180                 185                 190         


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
        195                 200                 205             


Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn 
    210                 215                 220                 


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser 
225                 230                 235                 240 


Lys 
    


<210>  54
<211>  242
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "Fab 0052, mouse VH - human IgG4 CH1"

<400>  54

Met Glu Trp Thr Trp Val Phe Leu Phe Leu Leu Ser Val Thr Ala Gly 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Pro Met Lys 
            20                  25                  30          


Pro Gly Ala Ser Val Lys Ile Ser Cys Lys Ala Thr Gly Tyr Thr Phe 
        35                  40                  45              


Ser Ser His Trp Ile Glu Trp Ile Lys Gln Arg Pro Gly His Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Glu Ile Leu Pro Gly Ser Gly Asn Thr Asn Tyr Asn 
65                  70                  75                  80  


Glu Lys Phe Lys Gly Lys Ala Thr Phe Thr Ala Asp Thr Ser Ser Asn 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Cys Cys Ala Arg Gly Tyr Tyr Gly Leu Asn Tyr Asp Trp Tyr Phe 
        115                 120                 125             


Asp Val Trp Gly Ala Gly Thr Thr Val Thr Val Ser Ser Ala Ser Thr 
    130                 135                 140                 


Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser 
145                 150                 155                 160 


Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu 
                165                 170                 175     


Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His 
            180                 185                 190         


Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser 
        195                 200                 205             


Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys 
    210                 215                 220                 


Asn Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu 
225                 230                 235                 240 


Ser Lys 
        


<210>  55
<211>  233
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "Fab 0082, mouse VH - human IgG4 CH1"

<400>  55

Met Asp Phe Gly Leu Ile Phe Phe Ile Val Ala Leu Leu Lys Gly Val 
1               5                   10                  15      


Gln Cys Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser 
        35                  40                  45              


Arg Tyr Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Ala Pro 
65                  70                  75                  80  


Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr 
                85                  90                  95      


Leu Tyr Leu Gln Met Ser Glu Val Arg Ser Glu Asp Thr Ala Leu Tyr 
            100                 105                 110         


Tyr Cys Ala Ser Gly Val Phe Thr Ser Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Ser Lys 
225                 230             


<210>  56
<211>  240
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "Fab AP-3, mouse VH - human IgG4 CH1"

<400>  56

Met Glu Trp Ser Gly Val Phe Ile Phe Leu Leu Ser Val Thr Ala Asp 
1               5                   10                  15      


Val His Ser Gln Val Gln Leu Gln Gln Ser Gly Ala Glu Leu Val Arg 
            20                  25                  30          


Pro Gly Thr Ser Val Lys Ile Ser Cys Lys Ala Ser Gly Tyr Thr Phe 
        35                  40                  45              


Thr Asn Tyr Trp Leu Gly Trp Val Lys Gln Arg Pro Gly His Gly Leu 
    50                  55                  60                  


Glu Trp Ile Gly Asp Ile Tyr Pro Gly Gly Gly Tyr Asn Lys Tyr Asn 
65                  70                  75                  80  


Glu Asn Phe Lys Gly Lys Ala Thr Leu Thr Ala Asp Thr Ser Ser Ser 
                85                  90                  95      


Thr Ala Tyr Met Gln Leu Ser Ser Leu Thr Ser Glu Asp Ser Ala Val 
            100                 105                 110         


Tyr Phe Cys Ala Arg Glu Tyr Gly Asn Tyr Asp Tyr Ala Met Asp Ser 
        115                 120                 125             


Trp Gly Gln Gly Thr Ser Val Thr Val Ser Ser Ala Ser Thr Lys Gly 
    130                 135                 140                 


Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser 
145                 150                 155                 160 


Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val 
                165                 170                 175     


Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe 
            180                 185                 190         


Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val 
        195                 200                 205             


Thr Val Pro Ser Ser Ser Leu Gly Thr Lys Thr Tyr Thr Cys Asn Val 
    210                 215                 220                 


Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Arg Val Glu Ser Lys 
225                 230                 235                 240 


<210>  57
<211>  239
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "Fab AP-3, LC (mouse VL - human Kappa CL)"

<400>  57

Met Arg Cys Leu Ala Glu Phe Leu Gly Leu Leu Val Leu Trp Ile Pro 
1               5                   10                  15      


Gly Ala Ile Gly Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Arg Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Cys Trp Phe Leu Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe 
                85                  90                  95      


Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln His Leu Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  58
<211>  239
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "Fab AP-3.LC.C34S, LC (mouse VL - human Kappa CL)"

<400>  58

Met Arg Cys Leu Ala Glu Phe Leu Gly Leu Leu Val Leu Trp Ile Pro 
1               5                   10                  15      


Gly Ala Ile Gly Asp Ile Val Met Thr Gln Ala Ala Pro Ser Val Pro 
            20                  25                  30          


Val Thr Pro Gly Glu Ser Val Ser Ile Ser Cys Arg Ser Ser Arg Ser 
        35                  40                  45              


Leu Leu His Ser Asn Gly Asn Thr Tyr Leu Ser Trp Phe Leu Gln Arg 
    50                  55                  60                  


Pro Gly Gln Ser Pro Gln Leu Leu Ile Tyr Arg Met Ser Asn Leu Ala 
65                  70                  75                  80  


Ser Gly Val Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Ala Phe 
                85                  90                  95      


Thr Leu Arg Ile Ser Arg Val Glu Ala Glu Asp Val Gly Val Tyr Tyr 
            100                 105                 110         


Cys Met Gln His Leu Glu Tyr Pro Phe Thr Phe Gly Ser Gly Thr Lys 
        115                 120                 125             


Leu Glu Ile Lys Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro 
    130                 135                 140                 


Pro Ser Asp Glu Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu 
145                 150                 155                 160 


Leu Asn Asn Phe Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp 
                165                 170                 175     


Asn Ala Leu Gln Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp 
            180                 185                 190         


Ser Lys Asp Ser Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys 
        195                 200                 205             


Ala Asp Tyr Glu Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln 
    210                 215                 220                 


Gly Leu Ser Ser Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
225                 230                 235                 


<210>  59
<211>  7
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "linker, L2"

<400>  59

Gly Ser Gly Gly Gly Gly Ser 
1               5           


<210>  60
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "linker, L3"

<400>  60

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
1               5                   10          


<210>  61
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "linker, L4a"

<400>  61

Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser 
    


<210>  62
<211>  17
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "linker, L4b"

<400>  62

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Ser 
    


<210>  63
<211>  22
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "linker, L5"

<400>  63

Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser 
            20          


<210>  64
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "linker, L6"

<400>  64

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25          


<210>  65
<211>  32
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "linker, L7"

<400>  65

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30          


<210>  66
<211>  37
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "linker, L8"

<400>  66

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ser 
        35          


<210>  67
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "linker, L9"

<400>  67

Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly 
1               5                   10                  15      


Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser 
            20                  25                  30          


Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 
        35                  40          


<210>  68
<211>  16
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "linker, L10"

<400>  68

Tyr Gly Pro Pro Ser Pro Ser Ser Pro Ala Pro Glu Phe Leu Gly Gly 
1               5                   10                  15      


<210>  69
<211>  12
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "Purification tag, HPC4 tag"

<400>  69

Glu Asp Gln Val Asp Pro Arg Leu Ile Asp Gly Lys 
1               5                   10          


<210>  70
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 50"

<400>  70
caacacttac ttgtcctggt tcctgcag                                          28


<210>  71
<211>  28
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 51"

<400>  71
ctgcaggaac caggacaagt aagtgttg                                          28


<210>  72
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 69"

<400>  72
gctctagact aacactcatt cctgttgaag ctcttg                                 36


<210>  73
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 98"

<400>  73
tttaaagaat tcctaacact ctcccctgtt gaagctctt                              39


<210>  74
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 100"

<400>  74
tttaaagaat tctcatttac ccagagacag ggagaggct                              39


<210>  75
<211>  21
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 312"

<400>  75
gtctaccaca acacacgtga c                                                 21


<210>  76
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 339"

<400>  76
actggatggt gggaagatgg atacagt                                           27


<210>  77
<211>  27
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 341"

<400>  77
agatccaggg gctagcggat agacaga                                           27


<210>  78
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 348"

<400>  78
ggagctggtg gtggcatctc aggacctttg                                        30


<210>  79
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 347"

<400>  79
cctgtaggac cagagggctc caaggacact                                        30


<210>  80
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 448"

<400>  80
tttaaaaagc ttgccgccac catggagacc cctgcctggc cccgggtc                    48


<210>  81
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 449"

<400>  81
tttaaagaat tcctattctc taaattcccc tttctcctgg cccataca                    48


<210>  82
<211>  75
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 466"

<400>  82
ggaggtggcg ggtctggtgg cgggggatca ggcgggggag gttcctcagg cactacaaat       60

actgtggcag catat                                                        75


<210>  83
<211>  75
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 467"

<400>  83
ggaacctccc ccgcctgatc ccccgccacc agacccgcca cctccttctc taaattcccc       60

tttctcctgg cccat                                                        75


<210>  84
<211>  65
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 483"

<400>  84
aaatttaagc ttactagtcc tgcaggttta aacgaatttg gatccggagg tggcgggtct       60

ggtgg                                                                   65


<210>  85
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 484"

<400>  85
gaatttagcg gccgcgaatt cggatccgga acctcccccg cctgatcc                    48


<210>  86
<211>  81
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 485"

<400>  86
aaatttgaat tcttacttgc cgtcgatcag tctggggtcc acctggtcct cacactctcc       60

cctgttgaag ctctttgtga c                                                 81


<210>  87
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 486"

<400>  87
acggatctct agcaagcttc gtacggtggc                                        30


<210>  88
<211>  81
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 487"

<400>  88
aaatttgaat tcttacttgc cgtcgatcag tctggggtcc acctggtcct ctttggactc       60

aactctcttg tccaccttgg t                                                 81


<210>  89
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 488"

<400>  89
aaatttgaat tcttatttgg actcaactct cttgtccacc ttggt                       45


<210>  90
<211>  30
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 489"

<400>  90
acggatctct agcaagcttg ctagcaccaa                                        30


<210>  91
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 490"

<400>  91
aaatttaagc ttgccgccac catggatttt gggctgattt tttttattgt tgct             54


<210>  92
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 491"

<400>  92
aaatttgcta gctgcagaga cagtgaccag agtcccttgg cccca                       45


<210>  93
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 492"

<400>  93
aaatttaagc ttgccgccac catgaagtca cagacccagg tcttcgtatt t                51


<210>  94
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 493"

<400>  94
aaatttaagc ttgccgccac catgaagttg cctgttgggc tgttggtgct g                51


<210>  95
<211>  38
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 494"

<400>  95
aaatttcgta cgttctattt ccagcttggt cccccctc                               38


<210>  96
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 495"

<400>  96
aaatttcgta cgttttattt ccagcttggt cccccctccg aa                          42


<210>  97
<211>  69
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 512"

<400>  97
aaatttggat ccgaggtgaa acttctcgag tctggaggtg gcctggtgca gcctggaggt       60

tccctgaaa                                                               69


<210>  98
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 513"

<400>  98
tttaaaggat tctttaccca gagacaggga gaggct                                 36


<210>  99
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 514"

<400>  99
aaatttggat cctttggact caactctctt gtccaccttg gt                          42


<210>  100
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 546"

<400>  100
aaatttaagc ttgccgccac catgaacttg gggctcagct tgattttcct tgtc             54


<210>  101
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 547"

<400>  101
aaatttgcta gctgaggaga cggtgactga ggttccttga cc                          42


<210>  102
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 548"

<400>  102
aaatttaagc ttgccgccac catggattca caggcccagg ttcttatatt gctg             54


<210>  103
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 549"

<400>  103
aaatttcgta cgtttcagct ccagcttggt cccagcaccg aa                          42


<210>  104
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 551"

<400>  104
aaatttaaat ttggatccga tgttgtgatg acccaaactc cactctcc                    48


<210>  105
<211>  42
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 552"

<400>  105
aaatttaaat ttggatccac actctcccct gttgaagctc tt                          42


<210>  106
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 572"

<400>  106
aaatttaagc ttgccgccac catggatttt gggctgattt tttttattgt tgct             54


<210>  107
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 574"

<400>  107
aaatttaagc ttgccgccac catgaagttg cctgttgggc tgttggtgc                   49


<210>  108
<211>  84
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 583"

<400>  108
aaatttggat ccggaacctc ccccgcctga tcccccgcca ccagacccgc cacctccaca       60

ctctcccctg ttgaagctct ttgt                                              84


<210>  109
<211>  99
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 584"

<400>  109
aaatttggat ccagacccgc cacctccgga acctcccccg cctgatcccc cgccaccaga       60

cccgccacct ccacactctc ccctgttgaa gctctttgt                              99


<210>  110
<211>  69
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 585"

<400>  110
aaatttggat cctgatcccc cgccaccaga cccgccacct ccacactctc ccctgttgaa       60

gctctttgt                                                               69


<210>  111
<211>  69
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 586"

<400>  111
aaatttggat ccggtggcgg gggatcaggc gggggaggtt cctcaggcac tacaaatact       60

gtggcagca                                                               69


<210>  112
<211>  87
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 587"

<400>  112
aaatttggat ccggaacctc ccccgcctga tcccccgcca ccagacccgc cacctccttt       60

acccagagac agggagaggc tcttctg                                           87


<210>  113
<211>  102
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 588"

<400>  113
aaatttggat ccagacccgc cacctccgga acctcccccg cctgatcccc cgccaccaga       60

cccgccacct cctttaccca gagacaggga gaggctcttc tg                         102


<210>  114
<211>  72
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 589"

<400>  114
aaatttggat cctgatcccc cgccaccaga cccgccacct cctttaccca gagacaggga       60

gaggctcttc tg                                                           72


<210>  115
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 590"

<400>  115
aaatttggat ccagacccgc cacctccaca ctctcccctg ttgaagctct ttgt             54


<210>  116
<211>  114
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 591"

<400>  116
aaatttggat ccagacccgc cacctccaga cccgccacct ccggaacctc ccccgcctga       60

tcccccgcca ccagacccgc cacctccaca ctctcccctg ttgaagctct ttgt            114


<210>  117
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 592"

<400>  117
aaatttggat cctgatcccc cgccaccttt acccagagac agggagaggc tcttctg          57


<210>  118
<211>  117
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 593"

<400>  118
aaatttggat ccagacccgc cacctccaga cccgccacct ccggaacctc ccccgcctga       60

tcccccgcca ccagacccgc cacctccttt acccagagac agggagaggc tcttctg         117


<210>  119
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 598"

<400>  119
ggaaacacct attttcattg ggccctgcag aaaccaggcc agtct                       45


<210>  120
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 599"

<400>  120
agactggcct ggtttctgca gggcccaatg aaaataggtg tttcc                       45


<210>  121
<211>  36
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 610"

<400>  121
gctctagact aacactcatt cctgttgaag ctcttg                                 36


<210>  122
<211>  38
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 613"

<400>  122
aaaaatctag aatagacaga tgggggtgtc gttttggc                               38


<210>  123
<211>  34
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 614"

<400>  123
aaaaatctag acttgaccag gcatcctaga gtca                                   34


<210>  124
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 615"

<400>  124
aaaaatctag aaggggccag tggatagact gatgg                                  35


<210>  125
<211>  35
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 616"

<400>  125
aaaaatctag aagggaccaa gggatagaca gatgg                                  35


<210>  126
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 617"

<400>  126
aaatttaagc ttgccgccac catggaatgg acctgggtct ttctcttcct                  50


<210>  127
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 618"

<400>  127
aaatttgcta gctgaggaga cggtgaccgt ggtccctgc                              39


<210>  128
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 619"

<400>  128
aaatttaagc ttgccgccac catgatgtcc tctgctcagt tccttggt                    48


<210>  129
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 620"

<400>  129
aaatttcgta cgtttcatct ccagtttggt cccccctcc                              39


<210>  130
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 627"

<400>  130
aaatttaagc ttgccgccac catgggttgg agctgtatca tcttctttct                  50


<210>  131
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 628"

<400>  131
aaatttgcta gctgcagaga cagtgaccag agtcccttg                              39


<210>  132
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 682"

<400>  132
gatagcagta cgataaacta taacccatct ctaaaggata aattc                       45


<210>  133
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 683"

<400>  133
gaatttatcc tttagagatg ggttatagtt tatcgtactg ctatc                       45


<210>  134
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 684"

<400>  134
tctgaggact ctgccgtcta ttactgtgca agagggtact acggt                       45


<210>  135
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 685"

<400>  135
accgtagtac cctcttgcac agtaatagac ggcagagtcc tcaga                       45


<210>  136
<211>  81
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 686"

<400>  136
tgctgccaca gtatttgtag tgcctgatcc ccccaggaac tcaggtgctg gggatgatgg       60

ggatggggga ccatatttgg a                                                 81


<210>  137
<211>  51
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 687"

<400>  137
ccagcacctg agttcctggg gggatcaggc actacaaata ctgtggcagc a                51


<210>  138
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 688"

<400>  138
gatagcagta cgataaacta tgcgccatct ctaaaggata aattc                       45


<210>  139
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 689"

<400>  139
gaatttatcc tttagagatg gcgcatagtt tatcgtactg ctatc                       45


<210>  140
<211>  54
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 699"

<400>  140
aaatttggat ccggcggggg aggttcctca ggcactacaa atactgtggc agca             54


<210>  141
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 700"

<400>  141
aaatttggat cctcaggcac tacaaatact gtggcagca                              39


<210>  142
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 701"

<400>  142
accaaggtgg acaagagagt tgagtccaaa tcaggcacta caaatactgt ggcagca          57


<210>  143
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 702"

<400>  143
tgctgccaca gtatttgtag tgcctgattt ggactcaact ctcttgtcca ccttggtgtt       60


<210>  144
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 703"

<400>  144
gtcacaaaga gcttcaacag gggagagtgt tcaggcacta caaatactgt ggcagca          57


<210>  145
<211>  57
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 704"

<400>  145
tgctgccaca gtatttgtag tgcctgaaca ctctcccctg ttgaagctct ttgtgac          57


<210>  146
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 800"

<400>  146
cagaagagcc tctccctgtc tctgggtaaa tcaggcacta caaatactgt ggcagcatat       60


<210>  147
<211>  60
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 801"

<400>  147
atatgctgcc acagtatttg tagtgcctga tttacccaga gacagggaga ggctcttctg       60


<210>  148
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 842"

<400>  148
aaatttaagc ttgccgccac catgaggtgc ctagctgagt tcctggggc                   49


<210>  149
<211>  45
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 843"

<400>  149
aaatttcgta cgttttattt ccaactttgt ccccgagccg aacgt                       45


<210>  150
<211>  49
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 844"

<400>  150
aaatttaagc ttgccgccac catggaatgg agcggggtct ttatctttc                   49


<210>  151
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 845"

<400>  151
aaatttgcta gctgaggaga cggtgactga ggttccttg                              39


<210>  152
<211>  55
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer 1000"

<400>  152
ctgtctctgg gtaaacacca tcaccaccac cactgagaat tccccgacct cgacc            55


<210>  153
<211>  55
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 1001"

<400>  153
gaggtcgggg aattctcagt ggtggtggtg atggtgttta cccagagaca gggag            55


<210>  154
<211>  48
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 1002"

<400>  154
ctcttttaaa aggggtccag tgtgagtcca aatatggtcc cccatgcc                    48


<210>  155
<211>  50
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 1003"

<400>  155
catgggggac catatttgga ctcacactgg acccctttta aaagagcaac                  50


<210>  156
<211>  233
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "0061VH-CH1"

<400>  156

Met Asp Phe Gly Leu Ile Phe Phe Ile Val Ala Leu Leu Lys Gly Val 
1               5                   10                  15      


Gln Cys Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro 
            20                  25                  30          


Gly Gly Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser 
        35                  40                  45              


Arg Tyr Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu 
    50                  55                  60                  


Trp Ile Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Asn Pro 
65                  70                  75                  80  


Ser Leu Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr 
                85                  90                  95      


Leu Tyr Leu Gln Met Ser Glu Val Arg Ser Glu Asp Thr Ala Leu Tyr 
            100                 105                 110         


Tyr Cys Ala Ser Gly Val Phe Thr Ser Trp Gly Gln Gly Thr Leu Val 
        115                 120                 125             


Thr Val Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala 
    130                 135                 140                 


Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu 
145                 150                 155                 160 


Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly 
                165                 170                 175     


Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser 
            180                 185                 190         


Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu 
        195                 200                 205             


Gly Thr Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr 
    210                 215                 220                 


Lys Val Asp Lys Arg Val Glu Ser Lys 
225                 230             


<210>  157
<211>  247
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "hIgG4-hinge-CH2-CH3"

<400>  157

Met Asp Phe Gly Leu Ile Phe Phe Ile Val Ala Leu Leu Lys Gly Val 
1               5                   10                  15      


Gln Cys Glu Ser Lys Tyr Gly Pro Pro Cys Pro Pro Cys Pro Ala Pro 
            20                  25                  30          


Glu Phe Leu Gly Gly Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys 
        35                  40                  45              


Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr Cys Val Val Val 
    50                  55                  60                  


Asp Val Ser Gln Glu Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp 
65                  70                  75                  80  


Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe 
                85                  90                  95      


Asn Ser Thr Tyr Arg Val Val Ser Val Leu Thr Val Leu His Gln Asp 
            100                 105                 110         


Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu 
        115                 120                 125             


Pro Ser Ser Ile Glu Lys Thr Ile Ser Lys Ala Lys Gly Gln Pro Arg 
    130                 135                 140                 


Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Gln Glu Glu Met Thr Lys 
145                 150                 155                 160 


Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp 
                165                 170                 175     


Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys 
            180                 185                 190         


Thr Thr Pro Pro Val Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser 
        195                 200                 205             


Arg Leu Thr Val Asp Lys Ser Arg Trp Gln Glu Gly Asn Val Phe Ser 
    210                 215                 220                 


Cys Ser Val Met His Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser 
225                 230                 235                 240 


Leu Ser Leu Ser Leu Gly Lys 
                245         


<210>  158
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "His6 tag"

<400>  158

His His His His His His 
1               5       


<210>  159
<211>  172
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "hTLT-1.18-188"

<400>  159

Met Ile Val Gly Ser Leu Pro Glu Val Leu Gln Ala Pro Val Gly Ser 
1               5                   10                  15      


Ser Ile Leu Val Gln Cys His Tyr Arg Leu Gln Asp Val Lys Ala Gln 
            20                  25                  30          


Lys Val Trp Cys Arg Phe Leu Pro Glu Gly Cys Gln Pro Leu Val Ser 
        35                  40                  45              


Ser Ala Val Asp Arg Arg Ala Pro Ala Gly Arg Arg Thr Phe Leu Thr 
    50                  55                  60                  


Asp Leu Gly Gly Gly Leu Leu Gln Val Glu Met Val Thr Leu Gln Glu 
65                  70                  75                  80  


Glu Asp Ala Gly Glu Tyr Gly Cys Met Val Asp Gly Ala Arg Gly Pro 
                85                  90                  95      


Gln Ile Leu His Arg Val Ser Leu Asn Ile Leu Pro Pro Glu Glu Glu 
            100                 105                 110         


Glu Glu Thr His Lys Ile Gly Ser Leu Ala Glu Asn Ala Phe Ser Asp 
        115                 120                 125             


Pro Ala Gly Ser Ala Asn Pro Leu Glu Pro Ser Gln Asp Glu Lys Ser 
    130                 135                 140                 


Ile Pro Leu Ile Trp Gly Ala Val Leu Leu Val Gly Leu Leu Val Ala 
145                 150                 155                 160 


Ala Val Val Leu Phe Ala Val Met Ala Lys Arg Lys 
                165                 170         


<210>  160
<211>  32
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 1004"

<400>  160
ggaattccat atgatagttg gcagcctccc tg                                     32


<210>  161
<211>  39
<212>  DNA
<213>  Artificial sequence

<220>
<223>  /note = "primer no. 1005"

<400>  161
ataagaatgc ggccgcctat ttcctcttgg ccatcacag                              39


<210>  162
<211>  215
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "Fab 0100 HC"

<400>  162

Glu Val Lys Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Lys Leu Ser Cys Ala Ala Ser Gly Phe Asp Phe Ser Arg Tyr 
            20                  25                  30          


Trp Met Thr Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Asp Ser Ser Thr Ile Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asp Lys Phe Ile Ile Ser Arg Asp Asn Ala Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Ser Glu Val Arg Ser Glu Asp Thr Ala Leu Tyr Tyr Cys 
                85                  90                  95      


Ala Ser Gly Val Phe Thr Ser Trp Gly Gln Gly Thr Leu Val Thr Val 
            100                 105                 110         


Ser Ala Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu Ala Pro Cys 
        115                 120                 125             


Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys Leu Val Lys 
    130                 135                 140                 


Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser Gly Ala Leu 
145                 150                 155                 160 


Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser Ser Gly Leu 
                165                 170                 175     


Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Ser Leu Gly Thr 
            180                 185                 190         


Lys Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn Thr Lys Val 
        195                 200                 205             


Asp Lys Arg Val Glu Ser Lys 
    210                 215 


<210>  163
<211>  219
<212>  PRT
<213>  Artificial sequence

<220>
<223>  /note = "Fab 0100 LC"

<400>  163

Asp Val Val Met Thr Gln Thr Pro Leu Ser Leu Pro Val Ser Leu Gly 
1               5                   10                  15      


Asp Gln Ala Ser Ile Ser Cys Arg Ser Ser Gln Ser Leu Val His Arg 
            20                  25                  30          


Asn Gly Asn Thr Tyr Phe His Trp Ala Leu Gln Lys Pro Gly Gln Ser 
        35                  40                  45              


Pro Lys Leu Leu Ile Tyr Lys Val Ser Asn Arg Phe Ser Gly Val Pro 
    50                  55                  60                  


Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Lys Ile 
65                  70                  75                  80  


Ser Arg Val Glu Ala Glu Asp Leu Gly Val Tyr Phe Cys Ser Gln Ser 
                85                  90                  95      


Thr His Val Pro Tyr Thr Phe Gly Gly Gly Thr Lys Leu Glu Ile Lys 
            100                 105                 110         


Arg Thr Val Ala Ala Pro Ser Val Phe Ile Phe Pro Pro Ser Asp Glu 
        115                 120                 125             


Gln Leu Lys Ser Gly Thr Ala Ser Val Val Cys Leu Leu Asn Asn Phe 
    130                 135                 140                 


Tyr Pro Arg Glu Ala Lys Val Gln Trp Lys Val Asp Asn Ala Leu Gln 
145                 150                 155                 160 


Ser Gly Asn Ser Gln Glu Ser Val Thr Glu Gln Asp Ser Lys Asp Ser 
                165                 170                 175     


Thr Tyr Ser Leu Ser Ser Thr Leu Thr Leu Ser Lys Ala Asp Tyr Glu 
            180                 185                 190         


Lys His Lys Val Tyr Ala Cys Glu Val Thr His Gln Gly Leu Ser Ser 
        195                 200                 205             


Pro Val Thr Lys Ser Phe Asn Arg Gly Glu Cys 
    210                 215                 


