                         SEQUENCE LISTING

<110>  Medizinische Hochschule Hannover
 
<120>  Means and methods for producing artificial capsular 
       polysaccharides of Neisseria meningitidis

<130>  R2067 PCT S3

<150>  EP 09 16 8765.7
<151>  2009-08-26

<160>  37    

<170>  PatentIn version 3.3

<210>  1
<211>  3114
<212>  DNA
<213>  Neisseria meningitidis

<400>  1
atggctgtta ttatatttgt taacggaatt cgggctgtaa atggccttgt taaatcatct     60

atcaatactg caaacgcttt tgctgaagaa ggactggatg ttcatttaat taattttgtt    120

ggcaatatta ctggagcaga gcatttatac cccccattcc acttacatcc caatgtcaaa    180

acctccagca tcatagattt atttaatgac attccagaaa atgttagctg ccgaaatact    240

cctttttatt ctattcatca acaattcttc aaagctgaat atagtgccca ctataagcat    300

gttttgatga aaattgaatc tttattatct gcagaagata gcattatctt cactcatcct    360

cttcaactgg aaatgtatcg tttagcgaat aatgatatca agtcaaaagc caaactaatt    420

gtacaaattc atggtaatta tatggaagaa atccataact atgaaatttt ggcacgaaat    480

atcgattatg ttgactatct tcaaacggta tctgatgaaa tgctggaaga aatgcattcc    540

catttcaaaa tcaaaaaaga caaattagtt tttattccaa acatcactta tcccatttca    600

ttagaaaaaa aagaagctga tttctttatt aaggataatg aagacatcga taatgctcag    660

aaatttaaac gtatctctat tgttggcagc attcagccaa gaaaaaacca attggatgcc    720

attaaaatca tcaataaaat taaaaatgaa aattacattt tacagatata tggcaaatct    780

attaataaag attactttga attaattaaa aaatatatta aagacaataa gttacaaaac    840

cgtatcttat tcaaaggtga atcttccgag caggaaattt atgaaaatac agatatcctg    900

atcatgacat cagaaagtga gggatttcca tatatattta tggaaggcat ggtgtatgat    960

attccaatcg ttgtatatga ttttaaatat ggagcgaatg attacagtaa ctataatgaa   1020

aatggttgtg tttttaaaac tggtgatatt tctggaatgg caaaaaaaat aattgagcta   1080

ttaaataacc cagaaaaata taaagaatta gttcaatata atcacaatcg cttcttaaaa   1140

gaatatgcaa aagatgtggt tatggctaaa tatttcacta ttcttccgcg cagctttaat   1200

aacgtatcat tatcgtctgc tttcagccga aaagaattgg acgaattcca aaatattact   1260

ttttctattg aagattctaa tgatttagct catatttgga atttcgagct aaccaatcct   1320

gcacaaaata tgaatttttt tgctttagtt ggcaagcgaa aatttccaat ggatgctcat   1380

atccaaggaa cacagtgtac gattaagata gctcataaaa agacagggaa tttattgtcg   1440

cttttactaa aaaaacgaaa tcagttgaat ttatcaaggg gatatacctt aattgcagaa   1500

gataatagct atgaaaaata tattggagca atatctaata aaggtaactt tgaaattatt   1560

gcaaataaaa agagctcatt agttactata aacaaaagta ccttagagtt gcatgagatt   1620

ccccatgaac tacatcagaa taaattactg attgctttac ccaacatgca aacgcctcta   1680

aaaattactg atgataattt aatacctatc caagcctcca taaaattaga aaagattgga   1740

aatacttatt acccatgttt cttgccatct ggcatattta ataatatctg cttagattac   1800

ggtgaagaat ccaaaattat taattttagt aaatattctt ataaatatat ctatgactca   1860

attcgtcata ttgagcaaca tacagatata tcggatatta tcgtttgcaa tgtttattct   1920

tgggaactta ttcgtgcctc agttattgag agccttatgg aatttaccgg aaaatgggaa   1980

aaacactttc agacttctcc taaaattgat tatcgatttg atcatgaagg taagcgttcg   2040

atggatgatg tcttttcaga agaaacattt attatggaat ttccgcgtaa aaatggtata   2100

gataagaaaa cagcagcctt ccaaaatata ccaaacagta ttgtaatgga gtatccgcag   2160

accaatggtt acagtatgcg cagtcattca ctgaaaagta atgtagttgc ggcaaaacat   2220

tttcttgaaa aattaaataa aattaaggta gatattaaat ttaaaaagca tgaccttgca   2280

aacatcaaaa aaatgaatcg aattatttat gagcatttag gcattaacat aaatatcgaa   2340

gcatttctaa aaccacgatt agaaaaattt aagcgtgaag aaaaatattt tcatgatttc   2400

ttcaaaagaa ataattttaa agaggtaatt tttccaagca cttattggaa tccaggtatt   2460

atttgtgctg cacataaaca aggtattaag gtatctgata ttcaatatgc tgccattact   2520

ccttatcatc ctgcgtattt taaatcacca aaatcacatt acgttgctga taaattgttc   2580

ttatggtctg aatattggaa tcatgagctt ttaccaaatc caacacgaga gattggttct   2640

ggtgccgcat attggtatgc attagatgat gtgagatttt cagaaaaact gaattatgac   2700

tatatctttc tatctcaaag taggatttct tcgcgcttgc ttagttttgc aattgagttt   2760

gcattaaaaa atcctcaact acagctttta ttttctaagc atccagatga aaatatagat   2820

ttaaagaaca gaattattcc tgataatctt ataatctcca cggaatcttc tatacaaggc   2880

atcaatgaat ctcgcgttgc tgtaggtgtt tattcaacta gcttatttga ggcattagca   2940

tgcggcaaac aaacttttgt tgttaaatat ccgggatatg aaattatgtc aaatgaaata   3000

gattcagggt tattctttgc agtagaaaca cctgaagaaa tgcttgagaa aacaagcccg   3060

aattgggtgg ctgtggcaga tattgaaaac cagttttttg gccaagaaaa ataa         3114


<210>  2
<211>  1037
<212>  PRT
<213>  Neisseria meningitidis

<400>  2

Met Ala Val Ile Ile Phe Val Asn Gly Ile Arg Ala Val Asn Gly Leu 
1               5                   10                  15      


Val Lys Ser Ser Ile Asn Thr Ala Asn Ala Phe Ala Glu Glu Gly Leu 
            20                  25                  30          


Asp Val His Leu Ile Asn Phe Val Gly Asn Ile Thr Gly Ala Glu His 
        35                  40                  45              


Leu Tyr Pro Pro Phe His Leu His Pro Asn Val Lys Thr Ser Ser Ile 
    50                  55                  60                  


Ile Asp Leu Phe Asn Asp Ile Pro Glu Asn Val Ser Cys Arg Asn Thr 
65                  70                  75                  80  


Pro Phe Tyr Ser Ile His Gln Gln Phe Phe Lys Ala Glu Tyr Ser Ala 
                85                  90                  95      


His Tyr Lys His Val Leu Met Lys Ile Glu Ser Leu Leu Ser Ala Glu 
            100                 105                 110         


Asp Ser Ile Ile Phe Thr His Pro Leu Gln Leu Glu Met Tyr Arg Leu 
        115                 120                 125             


Ala Asn Asn Asp Ile Lys Ser Lys Ala Lys Leu Ile Val Gln Ile His 
    130                 135                 140                 


Gly Asn Tyr Met Glu Glu Ile His Asn Tyr Glu Ile Leu Ala Arg Asn 
145                 150                 155                 160 


Ile Asp Tyr Val Asp Tyr Leu Gln Thr Val Ser Asp Glu Met Leu Glu 
                165                 170                 175     


Glu Met His Ser His Phe Lys Ile Lys Lys Asp Lys Leu Val Phe Ile 
            180                 185                 190         


Pro Asn Ile Thr Tyr Pro Ile Ser Leu Glu Lys Lys Glu Ala Asp Phe 
        195                 200                 205             


Phe Ile Lys Asp Asn Glu Asp Ile Asp Asn Ala Gln Lys Phe Lys Arg 
    210                 215                 220                 


Ile Ser Ile Val Gly Ser Ile Gln Pro Arg Lys Asn Gln Leu Asp Ala 
225                 230                 235                 240 


Ile Lys Ile Ile Asn Lys Ile Lys Asn Glu Asn Tyr Ile Leu Gln Ile 
                245                 250                 255     


Tyr Gly Lys Ser Ile Asn Lys Asp Tyr Phe Glu Leu Ile Lys Lys Tyr 
            260                 265                 270         


Ile Lys Asp Asn Lys Leu Gln Asn Arg Ile Leu Phe Lys Gly Glu Ser 
        275                 280                 285             


Ser Glu Gln Glu Ile Tyr Glu Asn Thr Asp Ile Leu Ile Met Thr Ser 
    290                 295                 300                 


Glu Ser Glu Gly Phe Pro Tyr Ile Phe Met Glu Gly Met Val Tyr Asp 
305                 310                 315                 320 


Ile Pro Ile Val Val Tyr Asp Phe Lys Tyr Gly Ala Asn Asp Tyr Ser 
                325                 330                 335     


Asn Tyr Asn Glu Asn Gly Cys Val Phe Lys Thr Gly Asp Ile Ser Gly 
            340                 345                 350         


Met Ala Lys Lys Ile Ile Glu Leu Leu Asn Asn Pro Glu Lys Tyr Lys 
        355                 360                 365             


Glu Leu Val Gln Tyr Asn His Asn Arg Phe Leu Lys Glu Tyr Ala Lys 
    370                 375                 380                 


Asp Val Val Met Ala Lys Tyr Phe Thr Ile Leu Pro Arg Ser Phe Asn 
385                 390                 395                 400 


Asn Val Ser Leu Ser Ser Ala Phe Ser Arg Lys Glu Leu Asp Glu Phe 
                405                 410                 415     


Gln Asn Ile Thr Phe Ser Ile Glu Asp Ser Asn Asp Leu Ala His Ile 
            420                 425                 430         


Trp Asn Phe Glu Leu Thr Asn Pro Ala Gln Asn Met Asn Phe Phe Ala 
        435                 440                 445             


Leu Val Gly Lys Arg Lys Phe Pro Met Asp Ala His Ile Gln Gly Thr 
    450                 455                 460                 


Gln Cys Thr Ile Lys Ile Ala His Lys Lys Thr Gly Asn Leu Leu Ser 
465                 470                 475                 480 


Leu Leu Leu Lys Lys Arg Asn Gln Leu Asn Leu Ser Arg Gly Tyr Thr 
                485                 490                 495     


Leu Ile Ala Glu Asp Asn Ser Tyr Glu Lys Tyr Ile Gly Ala Ile Ser 
            500                 505                 510         


Asn Lys Gly Asn Phe Glu Ile Ile Ala Asn Lys Lys Ser Ser Leu Val 
        515                 520                 525             


Thr Ile Asn Lys Ser Thr Leu Glu Leu His Glu Ile Pro His Glu Leu 
    530                 535                 540                 


His Gln Asn Lys Leu Leu Ile Ala Leu Pro Asn Met Gln Thr Pro Leu 
545                 550                 555                 560 


Lys Ile Thr Asp Asp Asn Leu Ile Pro Ile Gln Ala Ser Ile Lys Leu 
                565                 570                 575     


Glu Lys Ile Gly Asn Thr Tyr Tyr Pro Cys Phe Leu Pro Ser Gly Ile 
            580                 585                 590         


Phe Asn Asn Ile Cys Leu Asp Tyr Gly Glu Glu Ser Lys Ile Ile Asn 
        595                 600                 605             


Phe Ser Lys Tyr Ser Tyr Lys Tyr Ile Tyr Asp Ser Ile Arg His Ile 
    610                 615                 620                 


Glu Gln His Thr Asp Ile Ser Asp Ile Ile Val Cys Asn Val Tyr Ser 
625                 630                 635                 640 


Trp Glu Leu Ile Arg Ala Ser Val Ile Glu Ser Leu Met Glu Phe Thr 
                645                 650                 655     


Gly Lys Trp Glu Lys His Phe Gln Thr Ser Pro Lys Ile Asp Tyr Arg 
            660                 665                 670         


Phe Asp His Glu Gly Lys Arg Ser Met Asp Asp Val Phe Ser Glu Glu 
        675                 680                 685             


Thr Phe Ile Met Glu Phe Pro Arg Lys Asn Gly Ile Asp Lys Lys Thr 
    690                 695                 700                 


Ala Ala Phe Gln Asn Ile Pro Asn Ser Ile Val Met Glu Tyr Pro Gln 
705                 710                 715                 720 


Thr Asn Gly Tyr Ser Met Arg Ser His Ser Leu Lys Ser Asn Val Val 
                725                 730                 735     


Ala Ala Lys His Phe Leu Glu Lys Leu Asn Lys Ile Lys Val Asp Ile 
            740                 745                 750         


Lys Phe Lys Lys His Asp Leu Ala Asn Ile Lys Lys Met Asn Arg Ile 
        755                 760                 765             


Ile Tyr Glu His Leu Gly Ile Asn Ile Asn Ile Glu Ala Phe Leu Lys 
    770                 775                 780                 


Pro Arg Leu Glu Lys Phe Lys Arg Glu Glu Lys Tyr Phe His Asp Phe 
785                 790                 795                 800 


Phe Lys Arg Asn Asn Phe Lys Glu Val Ile Phe Pro Ser Thr Tyr Trp 
                805                 810                 815     


Asn Pro Gly Ile Ile Cys Ala Ala His Lys Gln Gly Ile Lys Val Ser 
            820                 825                 830         


Asp Ile Gln Tyr Ala Ala Ile Thr Pro Tyr His Pro Ala Tyr Phe Lys 
        835                 840                 845             


Ser Pro Lys Ser His Tyr Val Ala Asp Lys Leu Phe Leu Trp Ser Glu 
    850                 855                 860                 


Tyr Trp Asn His Glu Leu Leu Pro Asn Pro Thr Arg Glu Ile Gly Ser 
865                 870                 875                 880 


Gly Ala Ala Tyr Trp Tyr Ala Leu Asp Asp Val Arg Phe Ser Glu Lys 
                885                 890                 895     


Leu Asn Tyr Asp Tyr Ile Phe Leu Ser Gln Ser Arg Ile Ser Ser Arg 
            900                 905                 910         


Leu Leu Ser Phe Ala Ile Glu Phe Ala Leu Lys Asn Pro Gln Leu Gln 
        915                 920                 925             


Leu Leu Phe Ser Lys His Pro Asp Glu Asn Ile Asp Leu Lys Asn Arg 
    930                 935                 940                 


Ile Ile Pro Asp Asn Leu Ile Ile Ser Thr Glu Ser Ser Ile Gln Gly 
945                 950                 955                 960 


Ile Asn Glu Ser Arg Val Ala Val Gly Val Tyr Ser Thr Ser Leu Phe 
                965                 970                 975     


Glu Ala Leu Ala Cys Gly Lys Gln Thr Phe Val Val Lys Tyr Pro Gly 
            980                 985                 990         


Tyr Glu Ile Met Ser Asn Glu Ile  Asp Ser Gly Leu Phe  Phe Ala Val 
        995                 1000                 1005             


Glu Thr  Pro Glu Glu Met Leu  Glu Lys Thr Ser Pro  Asn Trp Val 
    1010                 1015                 1020             


Ala Val  Ala Asp Ile Glu Asn  Gln Phe Phe Gly Gln  Glu Lys 
    1025                 1030                 1035         


<210>  3
<211>  3114
<212>  DNA
<213>  Neisseria meningitidis

<400>  3
atggctgtta ttatatttgt taacggaatt cgggctgtaa atggccttgt taaatcatct     60

atcaatactg caaacgcttt tgctgaagaa ggactggatg ttcatttaat taattttgtt    120

ggcaatatta ctggagcaga gcatttatcc cccccattcc acttacatcc caatgtcaaa    180

acctccagca tcatagattt atttaatgac attccagaaa atgttagctg ccgaaatatt    240

cctttttatt ctatccatca acaattcttc aaagccgaat acagtgccca ctataagcat    300

gttttgatga aaattgaatc tttattatct gaagaagata gcattatctt cactcatcct    360

cttcaactgg aaatgtatcg tttagcgaat aataatatta agtcaaaagc caagctaatt    420

gtacaaattc atggtaacta tatggaagaa atccataact atgaaatttg ggcacgaaat    480

atcgattatg ttgattatct tcaaacggta tctgatgaaa tgctggaaga aatgcattcc    540

catttcaaaa tcaaaaaaga caaattagtt tttattccaa acatcactta tcccatttca    600

ttagaaaaaa aagaagctga tttctttatt aaggataatg aagacattga taatgctcag    660

aaatttaaac gtatctctat tgttggcagt attcagccaa gaaaaaacca attggatgcc    720

attaaaatca tcaataaaat taaaaatgaa aattacattt tacagatata tggcaaatct    780

attaataaag attactttga attaattaaa aaatatatta aagacaataa gttacaaaac    840

cgtatcttat tcaaaggtga atcttccgag caggaaattt atgagaatac agatatccta    900

atcatgacat ctcaaagcga aggctttggt tatatatttc tagagggtat ggtgtacgat    960

atccctatcc ttgcctataa ttttaaatat ggagcgaatg attttagcaa ttataatgaa   1020

aacgcttcag tttttaaaac tggtgatatt tctggaatgg caaaaaaaat aattgagcta   1080

ttaaataacc cagaaaaata taaagaatta gttcaatata atcacaatcg cttcttaaaa   1140

gaatatgcaa aagatgtggt tatggctaaa tatttcacta ttcttccgcg cagctttaat   1200

aacgtatcat tatcgtctgc tttcagccga aaagaattgg acgaattcca aaatattact   1260

ttttctattg aagattctaa tgatttagct catatttgga atttcgagct aaccaatcct   1320

gcacaaaata tgaatttttt tgctttagtt ggcaagcgaa aatttccaat ggatgctcat   1380

atccaaggaa cacagtgtac gattaagata gctcataaaa agacagggaa tttattgtcg   1440

cttttactaa aaaaacgaaa tcagttgaat ttatcaaggg gatatacctt aattgcagaa   1500

gataatagct atgaaaaata tattggagca atatctaata aaggtaactt tgaaattatt   1560

gcaaataaaa agaactcatt agttactata aacaaaagta ccttagagtt gcatgagatt   1620

ccccatgaac tacatcagaa taaattactg attgctttac ccaacatgca aacgcctcta   1680

aaaattactg atgataattt aatacctatc caagcctcca taaaattaga aaagattgga   1740

aatacttatt acccatgttt cttgccatct ggcatattta ataatatctg cttagattac   1800

ggtgaagaat ccaaaattat taattttagt aaatattctt ataaatatat ctatgactca   1860

attcgtcata ttgagcaaca tacagatata tcggatatta tcgtttgcaa tgtttattct   1920

tgggaactta ttcgtgcctc agttattgag agccttatgg aatttaccgg aaaatgggaa   1980

aaacactttc agacttctcc taaaattgat tatcgatttg atcatgaagg taagcgttcg   2040

atggatgatg tcttttcaga agaaacattt attatggaat ttccgcgtaa aaatggtata   2100

gataagaaaa cagcagcctt ccaaaatata ccaaacagta ttgtaatgga gtatccgcag   2160

accaatggtt acagtatgcg cagtcattca ctgaaaagta atgtagttgc ggcaaaacat   2220

tttcttgaaa aattaaataa aattaaggta gatattaaat ttaaaaagca tgaccttgca   2280

aacatcaaaa aaatgaatcg aattatttat gagcatttag gcattaacat aaatatcgaa   2340

gcatttctaa aaccacgatt agaaaaattt aagcgtgaag aaaaatattt tcatgatttc   2400

ttcaaaagaa ataattttaa agaggtaatt tttccaagca cttattggaa tccaggtatt   2460

atttgtgctg cacataaaca aggtattaag gtatctgata ttcaatatgc tgccattact   2520

ccttatcatc ctgcgtattt taaatcacca aaatcacatt acgttgctga taaattgttc   2580

ttatggtctg aatattggaa tcatgagctt ttaccaaatc caacacgaga gattggttct   2640

ggtgccgcat attggtatgc attagatgat gtgagatttt cagaaaaact gaattatgac   2700

tatatctttc tatctcaaag taggatttct tcgcgcttgc ttagttttgc aattgagttt   2760

gcattaaaaa atcctcaact acagctttta ttttctaagc atctagatga aaatatagat   2820

ttaaagaaca gaattattcc tgataatctt ataatctcca cggaatcttc tatacaaggc   2880

atcaatgaat ctcgcgttgc tgtaggtgtt tattcaacta gcttatttga ggcattagca   2940

tgcggcaaac aaacttttgt tgttaaatat ccgggatatg aaattatgtc aaatgaaata   3000

gattcagggt tattctttgc agtagaaaca cctgaagaaa tgcttgagaa aacaagcccg   3060

aattgggtgg ctgtggcaga tattgaaaac cagttttttg gccaagaaaa ataa         3114


<210>  4
<211>  1037
<212>  PRT
<213>  Neisseria meningitidis

<400>  4

Met Ala Val Ile Ile Phe Val Asn Gly Ile Arg Ala Val Asn Gly Leu 
1               5                   10                  15      


Val Lys Ser Ser Ile Asn Thr Ala Asn Ala Phe Ala Glu Glu Gly Leu 
            20                  25                  30          


Asp Val His Leu Ile Asn Phe Val Gly Asn Ile Thr Gly Ala Glu His 
        35                  40                  45              


Leu Ser Pro Pro Phe His Leu His Pro Asn Val Lys Thr Ser Ser Ile 
    50                  55                  60                  


Ile Asp Leu Phe Asn Asp Ile Pro Glu Asn Val Ser Cys Arg Asn Ile 
65                  70                  75                  80  


Pro Phe Tyr Ser Ile His Gln Gln Phe Phe Lys Ala Glu Tyr Ser Ala 
                85                  90                  95      


His Tyr Lys His Val Leu Met Lys Ile Glu Ser Leu Leu Ser Glu Glu 
            100                 105                 110         


Asp Ser Ile Ile Phe Thr His Pro Leu Gln Leu Glu Met Tyr Arg Leu 
        115                 120                 125             


Ala Asn Asn Asn Ile Lys Ser Lys Ala Lys Leu Ile Val Gln Ile His 
    130                 135                 140                 


Gly Asn Tyr Met Glu Glu Ile His Asn Tyr Glu Ile Trp Ala Arg Asn 
145                 150                 155                 160 


Ile Asp Tyr Val Asp Tyr Leu Gln Thr Val Ser Asp Glu Met Leu Glu 
                165                 170                 175     


Glu Met His Ser His Phe Lys Ile Lys Lys Asp Lys Leu Val Phe Ile 
            180                 185                 190         


Pro Asn Ile Thr Tyr Pro Ile Ser Leu Glu Lys Lys Glu Ala Asp Phe 
        195                 200                 205             


Phe Ile Lys Asp Asn Glu Asp Ile Asp Asn Ala Gln Lys Phe Lys Arg 
    210                 215                 220                 


Ile Ser Ile Val Gly Ser Ile Gln Pro Arg Lys Asn Gln Leu Asp Ala 
225                 230                 235                 240 


Ile Lys Ile Ile Asn Lys Ile Lys Asn Glu Asn Tyr Ile Leu Gln Ile 
                245                 250                 255     


Tyr Gly Lys Ser Ile Asn Lys Asp Tyr Phe Glu Leu Ile Lys Lys Tyr 
            260                 265                 270         


Ile Lys Asp Asn Lys Leu Gln Asn Arg Ile Leu Phe Lys Gly Glu Ser 
        275                 280                 285             


Ser Glu Gln Glu Ile Tyr Glu Asn Thr Asp Ile Leu Ile Met Thr Ser 
    290                 295                 300                 


Gln Ser Glu Gly Phe Gly Tyr Ile Phe Leu Glu Gly Met Val Tyr Asp 
305                 310                 315                 320 


Ile Pro Ile Leu Ala Tyr Asn Phe Lys Tyr Gly Ala Asn Asp Phe Ser 
                325                 330                 335     


Asn Tyr Asn Glu Asn Ala Ser Val Phe Lys Thr Gly Asp Ile Ser Gly 
            340                 345                 350         


Met Ala Lys Lys Ile Ile Glu Leu Leu Asn Asn Pro Glu Lys Tyr Lys 
        355                 360                 365             


Glu Leu Val Gln Tyr Asn His Asn Arg Phe Leu Lys Glu Tyr Ala Lys 
    370                 375                 380                 


Asp Val Val Met Ala Lys Tyr Phe Thr Ile Leu Pro Arg Ser Phe Asn 
385                 390                 395                 400 


Asn Val Ser Leu Ser Ser Ala Phe Ser Arg Lys Glu Leu Asp Glu Phe 
                405                 410                 415     


Gln Asn Ile Thr Phe Ser Ile Glu Asp Ser Asn Asp Leu Ala His Ile 
            420                 425                 430         


Trp Asn Phe Glu Leu Thr Asn Pro Ala Gln Asn Met Asn Phe Phe Ala 
        435                 440                 445             


Leu Val Gly Lys Arg Lys Phe Pro Met Asp Ala His Ile Gln Gly Thr 
    450                 455                 460                 


Gln Cys Thr Ile Lys Ile Ala His Lys Lys Thr Gly Asn Leu Leu Ser 
465                 470                 475                 480 


Leu Leu Leu Lys Lys Arg Asn Gln Leu Asn Leu Ser Arg Gly Tyr Thr 
                485                 490                 495     


Leu Ile Ala Glu Asp Asn Ser Tyr Glu Lys Tyr Ile Gly Ala Ile Ser 
            500                 505                 510         


Asn Lys Gly Asn Phe Glu Ile Ile Ala Asn Lys Lys Asn Ser Leu Val 
        515                 520                 525             


Thr Ile Asn Lys Ser Thr Leu Glu Leu His Glu Ile Pro His Glu Leu 
    530                 535                 540                 


His Gln Asn Lys Leu Leu Ile Ala Leu Pro Asn Met Gln Thr Pro Leu 
545                 550                 555                 560 


Lys Ile Thr Asp Asp Asn Leu Ile Pro Ile Gln Ala Ser Ile Lys Leu 
                565                 570                 575     


Glu Lys Ile Gly Asn Thr Tyr Tyr Pro Cys Phe Leu Pro Ser Gly Ile 
            580                 585                 590         


Phe Asn Asn Ile Cys Leu Asp Tyr Gly Glu Glu Ser Lys Ile Ile Asn 
        595                 600                 605             


Phe Ser Lys Tyr Ser Tyr Lys Tyr Ile Tyr Asp Ser Ile Arg His Ile 
    610                 615                 620                 


Glu Gln His Thr Asp Ile Ser Asp Ile Ile Val Cys Asn Val Tyr Ser 
625                 630                 635                 640 


Trp Glu Leu Ile Arg Ala Ser Val Ile Glu Ser Leu Met Glu Phe Thr 
                645                 650                 655     


Gly Lys Trp Glu Lys His Phe Gln Thr Ser Pro Lys Ile Asp Tyr Arg 
            660                 665                 670         


Phe Asp His Glu Gly Lys Arg Ser Met Asp Asp Val Phe Ser Glu Glu 
        675                 680                 685             


Thr Phe Ile Met Glu Phe Pro Arg Lys Asn Gly Ile Asp Lys Lys Thr 
    690                 695                 700                 


Ala Ala Phe Gln Asn Ile Pro Asn Ser Ile Val Met Glu Tyr Pro Gln 
705                 710                 715                 720 


Thr Asn Gly Tyr Ser Met Arg Ser His Ser Leu Lys Ser Asn Val Val 
                725                 730                 735     


Ala Ala Lys His Phe Leu Glu Lys Leu Asn Lys Ile Lys Val Asp Ile 
            740                 745                 750         


Lys Phe Lys Lys His Asp Leu Ala Asn Ile Lys Lys Met Asn Arg Ile 
        755                 760                 765             


Ile Tyr Glu His Leu Gly Ile Asn Ile Asn Ile Glu Ala Phe Leu Lys 
    770                 775                 780                 


Pro Arg Leu Glu Lys Phe Lys Arg Glu Glu Lys Tyr Phe His Asp Phe 
785                 790                 795                 800 


Phe Lys Arg Asn Asn Phe Lys Glu Val Ile Phe Pro Ser Thr Tyr Trp 
                805                 810                 815     


Asn Pro Gly Ile Ile Cys Ala Ala His Lys Gln Gly Ile Lys Val Ser 
            820                 825                 830         


Asp Ile Gln Tyr Ala Ala Ile Thr Pro Tyr His Pro Ala Tyr Phe Lys 
        835                 840                 845             


Ser Pro Lys Ser His Tyr Val Ala Asp Lys Leu Phe Leu Trp Ser Glu 
    850                 855                 860                 


Tyr Trp Asn His Glu Leu Leu Pro Asn Pro Thr Arg Glu Ile Gly Ser 
865                 870                 875                 880 


Gly Ala Ala Tyr Trp Tyr Ala Leu Asp Asp Val Arg Phe Ser Glu Lys 
                885                 890                 895     


Leu Asn Tyr Asp Tyr Ile Phe Leu Ser Gln Ser Arg Ile Ser Ser Arg 
            900                 905                 910         


Leu Leu Ser Phe Ala Ile Glu Phe Ala Leu Lys Asn Pro Gln Leu Gln 
        915                 920                 925             


Leu Leu Phe Ser Lys His Leu Asp Glu Asn Ile Asp Leu Lys Asn Arg 
    930                 935                 940                 


Ile Ile Pro Asp Asn Leu Ile Ile Ser Thr Glu Ser Ser Ile Gln Gly 
945                 950                 955                 960 


Ile Asn Glu Ser Arg Val Ala Val Gly Val Tyr Ser Thr Ser Leu Phe 
                965                 970                 975     


Glu Ala Leu Ala Cys Gly Lys Gln Thr Phe Val Val Lys Tyr Pro Gly 
            980                 985                 990         


Tyr Glu Ile Met Ser Asn Glu Ile  Asp Ser Gly Leu Phe  Phe Ala Val 
        995                 1000                 1005             


Glu Thr  Pro Glu Glu Met Leu  Glu Lys Thr Ser Pro  Asn Trp Val 
    1010                 1015                 1020             


Ala Val  Ala Asp Ile Glu Asn  Gln Phe Phe Gly Gln  Glu Lys 
    1025                 1030                 1035         


<210>  5
<211>  1461
<212>  DNA
<213>  Neisseria meningitidis

<400>  5
atgattatga gcaaaattag caaattggta acccacccaa accttttctt tcgagattat     60

ttcttaaaaa aagcaccgtt aaattatggc gaaaatatta aacctttacc agtcgaaacc    120

tcttctcata gcaaaaaaaa tacagcccat aaaacacccg tatcatccga ccaaccaatt    180

gaagatccat acccagtaac atttccaatt gatgtagttt atacttgggt agattcagat    240

gatgaaaaat tcaatgaaga acgcctaaag tttcaaaatt caagcacatc tgagactcta    300

caaggcaaag cagaaagcac cgatattgca agattccaat cacgcgacga attaaaatat    360

tcgattcgaa gcctgatgaa gtatgcccca tgggtaaatc atatttacat tgtaacaaat    420

ggtcaaatac caaaatggtt agataccaac aatacaaagg taacgattat ccctcactca    480

actattatcg acagtcaatt tctccctact tttaattctc acgtcattga atcctctcta    540

tataaaatcc caggattatc agagcattac atttatttca atgatgatgt catgctagct    600

agagatttaa gcccatctta tttctttaca agcagcggat tagcaaaact gtttattacc    660

aactctcgtc taccaaatgg ctataagaat gtgaaagaca caccaaccca atgggcctca    720

aaaaattccc gtgagctttt acatgcagaa acaggatttt gggctgaagc catgtttgca    780

catacttttc atccacaacg taaaagtgta catgaatcta ttgaacacct atggcatgaa    840

caattaaatg tttgtcgtca aaaccgtttc cgtgatattt cagatattaa catggcgaca    900

ttcctgcacc accattttgc cattttgaca ggccaagctc ttgctacacg cactaaatgt    960

atttacttta acgttcgctc tcctcaagca gctcagcatt acaaaacatt attagctcga   1020

aaaggaagcg aatacagccc acattctatc tgcttaaatg atcatacatc gagcaataaa   1080

aatattttat ctaattacga agccaaatta caaagctttt tagaaacata ctatccagat   1140

gtatcagaag cagaaattct ccttcctact aaatctgaag tagctgaatt agttaaacat   1200

aaagattatt taactgtata tactaaatta ttacctatta tcaataagca gctggtcaat   1260

aaatataata aaccttattc atatcttttc tattatttag gtttatctgc ccggttttta   1320

tttgaagaaa cgcaacaaga acactaccgg gaaactgctg aagaaaattt acaaatcttt   1380

tgtggcctaa acccaaaaca tacactagcc ctcaaatact tagcggatgt caccctcaca   1440

tcacagccta gtggacaata a                                             1461


<210>  6
<211>  486
<212>  PRT
<213>  Neisseria meningitidis

<400>  6

Met Ile Met Ser Lys Ile Ser Lys Leu Val Thr His Pro Asn Leu Phe 
1               5                   10                  15      


Phe Arg Asp Tyr Phe Leu Lys Lys Ala Pro Leu Asn Tyr Gly Glu Asn 
            20                  25                  30          


Ile Lys Pro Leu Pro Val Glu Thr Ser Ser His Ser Lys Lys Asn Thr 
        35                  40                  45              


Ala His Lys Thr Pro Val Ser Ser Asp Gln Pro Ile Glu Asp Pro Tyr 
    50                  55                  60                  


Pro Val Thr Phe Pro Ile Asp Val Val Tyr Thr Trp Val Asp Ser Asp 
65                  70                  75                  80  


Asp Glu Lys Phe Asn Glu Glu Arg Leu Lys Phe Gln Asn Ser Ser Thr 
                85                  90                  95      


Ser Glu Thr Leu Gln Gly Lys Ala Glu Ser Thr Asp Ile Ala Arg Phe 
            100                 105                 110         


Gln Ser Arg Asp Glu Leu Lys Tyr Ser Ile Arg Ser Leu Met Lys Tyr 
        115                 120                 125             


Ala Pro Trp Val Asn His Ile Tyr Ile Val Thr Asn Gly Gln Ile Pro 
    130                 135                 140                 


Lys Trp Leu Asp Thr Asn Asn Thr Lys Val Thr Ile Ile Pro His Ser 
145                 150                 155                 160 


Thr Ile Ile Asp Ser Gln Phe Leu Pro Thr Phe Asn Ser His Val Ile 
                165                 170                 175     


Glu Ser Ser Leu Tyr Lys Ile Pro Gly Leu Ser Glu His Tyr Ile Tyr 
            180                 185                 190         


Phe Asn Asp Asp Val Met Leu Ala Arg Asp Leu Ser Pro Ser Tyr Phe 
        195                 200                 205             


Phe Thr Ser Ser Gly Leu Ala Lys Leu Phe Ile Thr Asn Ser Arg Leu 
    210                 215                 220                 


Pro Asn Gly Tyr Lys Asn Val Lys Asp Thr Pro Thr Gln Trp Ala Ser 
225                 230                 235                 240 


Lys Asn Ser Arg Glu Leu Leu His Ala Glu Thr Gly Phe Trp Ala Glu 
                245                 250                 255     


Ala Met Phe Ala His Thr Phe His Pro Gln Arg Lys Ser Val His Glu 
            260                 265                 270         


Ser Ile Glu His Leu Trp His Glu Gln Leu Asn Val Cys Arg Gln Asn 
        275                 280                 285             


Arg Phe Arg Asp Ile Ser Asp Ile Asn Met Ala Thr Phe Leu His His 
    290                 295                 300                 


His Phe Ala Ile Leu Thr Gly Gln Ala Leu Ala Thr Arg Thr Lys Cys 
305                 310                 315                 320 


Ile Tyr Phe Asn Val Arg Ser Pro Gln Ala Ala Gln His Tyr Lys Thr 
                325                 330                 335     


Leu Leu Ala Arg Lys Gly Ser Glu Tyr Ser Pro His Ser Ile Cys Leu 
            340                 345                 350         


Asn Asp His Thr Ser Ser Asn Lys Asn Ile Leu Ser Asn Tyr Glu Ala 
        355                 360                 365             


Lys Leu Gln Ser Phe Leu Glu Thr Tyr Tyr Pro Asp Val Ser Glu Ala 
    370                 375                 380                 


Glu Ile Leu Leu Pro Thr Lys Ser Glu Val Ala Glu Leu Val Lys His 
385                 390                 395                 400 


Lys Asp Tyr Leu Thr Val Tyr Thr Lys Leu Leu Pro Ile Ile Asn Lys 
                405                 410                 415     


Gln Leu Val Asn Lys Tyr Asn Lys Pro Tyr Ser Tyr Leu Phe Tyr Tyr 
            420                 425                 430         


Leu Gly Leu Ser Ala Arg Phe Leu Phe Glu Glu Thr Gln Gln Glu His 
        435                 440                 445             


Tyr Arg Glu Thr Ala Glu Glu Asn Leu Gln Ile Phe Cys Gly Leu Asn 
    450                 455                 460                 


Pro Lys His Thr Leu Ala Leu Lys Tyr Leu Ala Asp Val Thr Leu Thr 
465                 470                 475                 480 


Ser Gln Pro Ser Gly Gln 
                485     


<210>  7
<211>  1638
<212>  DNA
<213>  Neisseria meningitidis

<400>  7
atgtttatac ttaataacag aaaatggcgt aaacttaaaa gagaccctag cgctttcttt     60

cgagatagta aatttaactt tttaagatat ttttctgcta aaaaatttgc aaagaatttt    120

aaaaattcat cacatatcca taaaactaat ataagtaaag ctcaatcaaa tatttcttca    180

accttaaaac aaaatcggaa acaagatatg ttaattccta ttaatttttt taattttgaa    240

tatatagtta aaaaacttaa caatcaaaac gcaataggtg tatatattct tccttctaat    300

cttactctta agcctgcatt atgtattcta gaatcacata aagaagactt tttaaataaa    360

tttcttctta ctatttcctc tgaaaattta aagcttcaat acaaatttaa tggacaaata    420

aaaaatccta agtccgtaaa tgaaatttgg acagatttat ttagcattgc tcatgttgac    480

atgaaactca gcacagatag aactttaagt tcatctatat ctcaattttg gttcagatta    540

gagttctgta aagaagataa ggattttatc ttatttccta cagctaacag atattctaga    600

aaactttgga agcactctat taaaaataat caattattta aagaaggcat acgaaactat    660

tcagaaatat cttcattacc ctatgaagaa gatcataatt ttgatattga tttagtattt    720

acttgggtca actcagaaga taagaattgg caagagttat ataaaaaata taagcccgac    780

tttaatagcg atgcaaccag tacatcaaga ttccttagta gagatgaatt aaaattcgca    840

ttacgctctt gggaaatgaa tggatccttc attcgaaaaa tttttattgt ctctaattgt    900

gctcccccag catggctaga tttaaataac cctaaaattc aatgggtata tcacgaagaa    960

attatgccac aaagtgccct tcctactttt agctcacatg ctattgaaac cagcttgcac   1020

catataccag gaattagtaa ctattttatt tacagcaatg acgacttcct attaactaaa   1080

ccattgaata aagacaattt cttctattcg aatggtattg caaagttaag attagaagca   1140

tggggaaatg ttaatggtga atgtactgaa ggagaacctg actacttaaa tggtgctcgc   1200

aatgcgaaca ctctcttaga aaaggaattt aaaaaattta ctactaaact acatactcac   1260

tcccctcaat ccatgagaac tgatatttta tttgagatgg aaaaaaaata tccagaagag   1320

tttaatagaa cactacataa taaattccga tctttagatg atattgcagt aacgggctat   1380

ctctatcatc attatgccct actctctgga cgagcactac aaagttctga caagacggaa   1440

cttgtacagc aaaatcatga tttcaaaaag aaactaaata atgtagtgac cttaactaaa   1500

gaaaggaatt ttgacaaact tcctttgagc gtatgtatca acgatggtgc tgatagtcac   1560

ttgaatgaag aatggaatgt tcaagttatt aagttcttag aaactctttt cccattacca   1620

tcatcatttg agaaataa                                                 1638


<210>  8
<211>  545
<212>  PRT
<213>  Neisseria meningitidis

<400>  8

Met Phe Ile Leu Asn Asn Arg Lys Trp Arg Lys Leu Lys Arg Asp Pro 
1               5                   10                  15      


Ser Ala Phe Phe Arg Asp Ser Lys Phe Asn Phe Leu Arg Tyr Phe Ser 
            20                  25                  30          


Ala Lys Lys Phe Ala Lys Asn Phe Lys Asn Ser Ser His Ile His Lys 
        35                  40                  45              


Thr Asn Ile Ser Lys Ala Gln Ser Asn Ile Ser Ser Thr Leu Lys Gln 
    50                  55                  60                  


Asn Arg Lys Gln Asp Met Leu Ile Pro Ile Asn Phe Phe Asn Phe Glu 
65                  70                  75                  80  


Tyr Ile Val Lys Lys Leu Asn Asn Gln Asn Ala Ile Gly Val Tyr Ile 
                85                  90                  95      


Leu Pro Ser Asn Leu Thr Leu Lys Pro Ala Leu Cys Ile Leu Glu Ser 
            100                 105                 110         


His Lys Glu Asp Phe Leu Asn Lys Phe Leu Leu Thr Ile Ser Ser Glu 
        115                 120                 125             


Asn Leu Lys Leu Gln Tyr Lys Phe Asn Gly Gln Ile Lys Asn Pro Lys 
    130                 135                 140                 


Ser Val Asn Glu Ile Trp Thr Asp Leu Phe Ser Ile Ala His Val Asp 
145                 150                 155                 160 


Met Lys Leu Ser Thr Asp Arg Thr Leu Ser Ser Ser Ile Ser Gln Phe 
                165                 170                 175     


Trp Phe Arg Leu Glu Phe Cys Lys Glu Asp Lys Asp Phe Ile Leu Phe 
            180                 185                 190         


Pro Thr Ala Asn Arg Tyr Ser Arg Lys Leu Trp Lys His Ser Ile Lys 
        195                 200                 205             


Asn Asn Gln Leu Phe Lys Glu Gly Ile Arg Asn Tyr Ser Glu Ile Ser 
    210                 215                 220                 


Ser Leu Pro Tyr Glu Glu Asp His Asn Phe Asp Ile Asp Leu Val Phe 
225                 230                 235                 240 


Thr Trp Val Asn Ser Glu Asp Lys Asn Trp Gln Glu Leu Tyr Lys Lys 
                245                 250                 255     


Tyr Lys Pro Asp Phe Asn Ser Asp Ala Thr Ser Thr Ser Arg Phe Leu 
            260                 265                 270         


Ser Arg Asp Glu Leu Lys Phe Ala Leu Arg Ser Trp Glu Met Asn Gly 
        275                 280                 285             


Ser Phe Ile Arg Lys Ile Phe Ile Val Ser Asn Cys Ala Pro Pro Ala 
    290                 295                 300                 


Trp Leu Asp Leu Asn Asn Pro Lys Ile Gln Trp Val Tyr His Glu Glu 
305                 310                 315                 320 


Ile Met Pro Gln Ser Ala Leu Pro Thr Phe Ser Ser His Ala Ile Glu 
                325                 330                 335     


Thr Ser Leu His His Ile Pro Gly Ile Ser Asn Tyr Phe Ile Tyr Ser 
            340                 345                 350         


Asn Asp Asp Phe Leu Leu Thr Lys Pro Leu Asn Lys Asp Asn Phe Phe 
        355                 360                 365             


Tyr Ser Asn Gly Ile Ala Lys Leu Arg Leu Glu Ala Trp Gly Asn Val 
    370                 375                 380                 


Asn Gly Glu Cys Thr Glu Gly Glu Pro Asp Tyr Leu Asn Gly Ala Arg 
385                 390                 395                 400 


Asn Ala Asn Thr Leu Leu Glu Lys Glu Phe Lys Lys Phe Thr Thr Lys 
                405                 410                 415     


Leu His Thr His Ser Pro Gln Ser Met Arg Thr Asp Ile Leu Phe Glu 
            420                 425                 430         


Met Glu Lys Lys Tyr Pro Glu Glu Phe Asn Arg Thr Leu His Asn Lys 
        435                 440                 445             


Phe Arg Ser Leu Asp Asp Ile Ala Val Thr Gly Tyr Leu Tyr His His 
    450                 455                 460                 


Tyr Ala Leu Leu Ser Gly Arg Ala Leu Gln Ser Ser Asp Lys Thr Glu 
465                 470                 475                 480 


Leu Val Gln Gln Asn His Asp Phe Lys Lys Lys Leu Asn Asn Val Val 
                485                 490                 495     


Thr Leu Thr Lys Glu Arg Asn Phe Asp Lys Leu Pro Leu Ser Val Cys 
            500                 505                 510         


Ile Asn Asp Gly Ala Asp Ser His Leu Asn Glu Glu Trp Asn Val Gln 
        515                 520                 525             


Val Ile Lys Phe Leu Glu Thr Leu Phe Pro Leu Pro Ser Ser Phe Glu 
    530                 535                 540                 


Lys 
545 


<210>  9
<211>  1893
<212>  DNA
<213>  Leishmania major

<400>  9
atgacgaacc cgtccaactc caacctgcag gccttgcgcg aggagctctg cacgcctggc     60

ctggatcagg gtcacctctt cgagggatgg ccggagactg tggatgagtg caacgagagg    120

cagatcgccc tcctcacaga tttgtacatg ttttccaaca tgtatcccgg cggcgttgct    180

cagtacatcc gcaacgggca cgagctgctg gcgcgtgaga gcgaagaggt ggactttgca    240

gcgctggaga tgccccctct catcttcgag gcgccgtcgc tgcaccggcg cacggctgag    300

aggacggcgc tggagaacgc cggaaccgcg atgctgtgca agacggtgtt cgtgctggtt    360

gctggcggtc tgggcgaacg tctgggctac tcgagcatca aggtgagcct gccggtggag    420

acggcgacga acacaacgta tctcgcctac tacctccggt gggcccagcg ggtggggggg    480

aaggaggtac catttgtgat aatgacctct gacgacacgc acgaccgcac gctgcagctc    540

ctgcgcgagc tgcagttgga ggtgcccaac ttgcatgtgc tcaagcaggg gcaggtcttc    600

tgttttgccg acagcgccgc gcacctcgcc ctggacgaga cagggaagct gctgcgcaag    660

ccacacggtc acggcgacgt gcactccctc atctacaacg cgactgtgaa gagagacgtg    720

gtgccggact ccggcgacgg taccgcgacg gcgcagccac tcgtgaacga ctggctggcg    780

gccggctacg agtccattgt cttcatccag gacaccaacg ccggcgcgac gatcacaatc    840

cccatcagcc tcgccttgag tgccgagcac tcgctcgaca tgaacttcac ctgcatccct    900

cgtgtgccga aggagccgat cgggctgcta tgccgaacca agaagaatag cggcgacccg    960

tggctggtcg cgaacgtgga gtacaacgtc tttgccgagg tctcgcgcgc gcttaacaag   1020

gatggtggcg atgaagtcag tgaccccact ggcttctccc cgttccctgg cagcgtcaac   1080

accctcgtgt tcaagctctc cagctacgtg gaccggctgc gggagtcgca cggtatcgtg   1140

ccggagttca tcaatcccaa gtactcggac gagacgcgcc gctccttcaa gaagcccgca   1200

cgcatcgagt ccctgatgca ggacatcgcg ctgctcttct ccgaggatga ctaccgtgtc   1260

ggcggtaccg tctttgagcg attctcgtac cagccagtga agaactcgct agaggaggcg   1320

gcagggcttg tggcgcaggg caacggcgcc tactgcgccg ccacgggaga ggctgccttc   1380

tacgagctgc agcggcgccg tctcaaggcc atcgggctgc cgctcttcta cagctcgcag   1440

ccggaggtga cggtggcgaa ggacgccttt ggcgtgcgtc tcttcccgat aatcgtgctg   1500

gatacgatgt gcgcgtcaag cggatccctc gacgaccttg cgcgcgtctt tccgacgccg   1560

gaaaaggtgc acatcgatca gcacagcacc ttgattgttg agggccgtgt catcatcgag   1620

agcctggagc tatacggtgc actcacgatt cgcggcccga cagactcgat ggcgctgccg   1680

cacgtagtac gaaacgctgt ggtgcgcaat gccggctggt cggtacacgc gatcttgtct   1740

ctctgcgctg ggcgcgatag caggctgtcc gaggtggacc gcatccgcgg gtttgtgctg   1800

aagaagacag ccatggcggt gatggactgc aatacgaagg gcgagtccga ggccggtgca   1860

ccgtctggtg cggctgaccc ggcaaagttg tag                                1893


<210>  10
<211>  630
<212>  PRT
<213>  Leishmania major

<400>  10

Met Thr Asn Pro Ser Asn Ser Asn Leu Gln Ala Leu Arg Glu Glu Leu 
1               5                   10                  15      


Cys Thr Pro Gly Leu Asp Gln Gly His Leu Phe Glu Gly Trp Pro Glu 
            20                  25                  30          


Thr Val Asp Glu Cys Asn Glu Arg Gln Ile Ala Leu Leu Thr Asp Leu 
        35                  40                  45              


Tyr Met Phe Ser Asn Met Tyr Pro Gly Gly Val Ala Gln Tyr Ile Arg 
    50                  55                  60                  


Asn Gly His Glu Leu Leu Ala Arg Glu Ser Glu Glu Val Asp Phe Ala 
65                  70                  75                  80  


Ala Leu Glu Met Pro Pro Leu Ile Phe Glu Ala Pro Ser Leu His Arg 
                85                  90                  95      


Arg Thr Ala Glu Arg Thr Ala Leu Glu Asn Ala Gly Thr Ala Met Leu 
            100                 105                 110         


Cys Lys Thr Val Phe Val Leu Val Ala Gly Gly Leu Gly Glu Arg Leu 
        115                 120                 125             


Gly Tyr Ser Ser Ile Lys Val Ser Leu Pro Val Glu Thr Ala Thr Asn 
    130                 135                 140                 


Thr Thr Tyr Leu Ala Tyr Tyr Leu Arg Trp Ala Gln Arg Val Gly Gly 
145                 150                 155                 160 


Lys Glu Val Pro Phe Val Ile Met Thr Ser Asp Asp Thr His Asp Arg 
                165                 170                 175     


Thr Leu Gln Leu Leu Arg Glu Leu Gln Leu Glu Val Pro Asn Leu His 
            180                 185                 190         


Val Leu Lys Gln Gly Gln Val Phe Cys Phe Ala Asp Ser Ala Ala His 
        195                 200                 205             


Leu Ala Leu Asp Glu Thr Gly Lys Leu Leu Arg Lys Pro His Gly His 
    210                 215                 220                 


Gly Asp Val His Ser Leu Ile Tyr Asn Ala Thr Val Lys Arg Asp Val 
225                 230                 235                 240 


Val Pro Asp Ser Gly Asp Gly Thr Ala Thr Ala Gln Pro Leu Val Asn 
                245                 250                 255     


Asp Trp Leu Ala Ala Gly Tyr Glu Ser Ile Val Phe Ile Gln Asp Thr 
            260                 265                 270         


Asn Ala Gly Ala Thr Ile Thr Ile Pro Ile Ser Leu Ala Leu Ser Ala 
        275                 280                 285             


Glu His Ser Leu Asp Met Asn Phe Thr Cys Ile Pro Arg Val Pro Lys 
    290                 295                 300                 


Glu Pro Ile Gly Leu Leu Cys Arg Thr Lys Lys Asn Ser Gly Asp Pro 
305                 310                 315                 320 


Trp Leu Val Ala Asn Val Glu Tyr Asn Val Phe Ala Glu Val Ser Arg 
                325                 330                 335     


Ala Leu Asn Lys Asp Gly Gly Asp Glu Val Ser Asp Pro Thr Gly Phe 
            340                 345                 350         


Ser Pro Phe Pro Gly Ser Val Asn Thr Leu Val Phe Lys Leu Ser Ser 
        355                 360                 365             


Tyr Val Asp Arg Leu Arg Glu Ser His Gly Ile Val Pro Glu Phe Ile 
    370                 375                 380                 


Asn Pro Lys Tyr Ser Asp Glu Thr Arg Arg Ser Phe Lys Lys Pro Ala 
385                 390                 395                 400 


Arg Ile Glu Ser Leu Met Gln Asp Ile Ala Leu Leu Phe Ser Glu Asp 
                405                 410                 415     


Asp Tyr Arg Val Gly Gly Thr Val Phe Glu Arg Phe Ser Tyr Gln Pro 
            420                 425                 430         


Val Lys Asn Ser Leu Glu Glu Ala Ala Gly Leu Val Ala Gln Gly Asn 
        435                 440                 445             


Gly Ala Tyr Cys Ala Ala Thr Gly Glu Ala Ala Phe Tyr Glu Leu Gln 
    450                 455                 460                 


Arg Arg Arg Leu Lys Ala Ile Gly Leu Pro Leu Phe Tyr Ser Ser Gln 
465                 470                 475                 480 


Pro Glu Val Thr Val Ala Lys Asp Ala Phe Gly Val Arg Leu Phe Pro 
                485                 490                 495     


Ile Ile Val Leu Asp Thr Met Cys Ala Ser Ser Gly Ser Leu Asp Asp 
            500                 505                 510         


Leu Ala Arg Val Phe Pro Thr Pro Glu Lys Val His Ile Asp Gln His 
        515                 520                 525             


Ser Thr Leu Ile Val Glu Gly Arg Val Ile Ile Glu Ser Leu Glu Leu 
    530                 535                 540                 


Tyr Gly Ala Leu Thr Ile Arg Gly Pro Thr Asp Ser Met Ala Leu Pro 
545                 550                 555                 560 


His Val Val Arg Asn Ala Val Val Arg Asn Ala Gly Trp Ser Val His 
                565                 570                 575     


Ala Ile Leu Ser Leu Cys Ala Gly Arg Asp Ser Arg Leu Ser Glu Val 
            580                 585                 590         


Asp Arg Ile Arg Gly Phe Val Leu Lys Lys Thr Ala Met Ala Val Met 
        595                 600                 605             


Asp Cys Asn Thr Lys Gly Glu Ser Glu Ala Gly Ala Pro Ser Gly Ala 
    610                 615                 620                 


Ala Asp Pro Ala Lys Leu 
625                 630 


<210>  11
<211>  1119
<212>  DNA
<213>  Neisseria meningitidis

<400>  11
atgaaagtct taaccgtctt tggcactcgc cctgaagcta ttaaaatggc gcctgtaatt     60

ctagagttac aaaaacataa cacaattact tcaaaagttt gcattactgc acagcatcgt    120

gaaatgctag atcaggtttt gagcctattc gaaatcaaag ctgattatga tttaaatatc    180

atgaaaccca accagagcct acaagaaatc acaacaaata tcatctcaag ccttaccgat    240

gttcttgaag atttcaaacc tgactgcgtc cttgctcacg gagacaccac aacaactttt    300

gcagctagcc ttgctgcatt ctatcaaaaa atacctgttg gccacattga agcaggcctg    360

agaacttata atttatactc tccttggcca gaggaagcaa ataggcgttt aacaagcgtt    420

ctaagccagt ggcattttgc acctactgaa gattctaaaa ataacttact atctgaatca    480

ataccttctg acaaagttat tgttactgga aatactgtca tagatgcact aatggtatct    540

ctagaaaaac taaaaataac tacaattaaa aaacaaatgg aacaagcttt tccatttatt    600

caggacaact ctaaagtaat tttaattacc gctcatagaa gagaaaatca tggggaaggt    660

attaaaaata ttggactttc tatcttagaa ttagctaaaa aatacccaac attctctttt    720

gtgattccgc tccatttaaa tcctaacgtt agaaaaccaa ttcaagattt attatcctct    780

gtgcacaatg ttcatcttat tgagccacaa gaatacttac cattcgtata tttaatgtct    840

aaaagccata taatattaag tgattcaggc ggcatacaag aagaagctcc atccctagga    900

aaaccagttc ttgtattaag agatactaca gaacgtcctg aagctgtagc tgcaggaact    960

gtaaaattag taggttctga aactcaaaat attattgaga gctttacaca actaattgaa   1020

taccctgaat attatgaaaa aatggctaat attgaaaacc cttacgggat aggtaatgcc   1080

tcaaaaatca ttgtagaaac tttattaaag aatagataa                          1119


<210>  12
<211>  372
<212>  PRT
<213>  Neisseria meningitidis

<400>  12

Met Lys Val Leu Thr Val Phe Gly Thr Arg Pro Glu Ala Ile Lys Met 
1               5                   10                  15      


Ala Pro Val Ile Leu Glu Leu Gln Lys His Asn Thr Ile Thr Ser Lys 
            20                  25                  30          


Val Cys Ile Thr Ala Gln His Arg Glu Met Leu Asp Gln Val Leu Ser 
        35                  40                  45              


Leu Phe Glu Ile Lys Ala Asp Tyr Asp Leu Asn Ile Met Lys Pro Asn 
    50                  55                  60                  


Gln Ser Leu Gln Glu Ile Thr Thr Asn Ile Ile Ser Ser Leu Thr Asp 
65                  70                  75                  80  


Val Leu Glu Asp Phe Lys Pro Asp Cys Val Leu Ala His Gly Asp Thr 
                85                  90                  95      


Thr Thr Thr Phe Ala Ala Ser Leu Ala Ala Phe Tyr Gln Lys Ile Pro 
            100                 105                 110         


Val Gly His Ile Glu Ala Gly Leu Arg Thr Tyr Asn Leu Tyr Ser Pro 
        115                 120                 125             


Trp Pro Glu Glu Ala Asn Arg Arg Leu Thr Ser Val Leu Ser Gln Trp 
    130                 135                 140                 


His Phe Ala Pro Thr Glu Asp Ser Lys Asn Asn Leu Leu Ser Glu Ser 
145                 150                 155                 160 


Ile Pro Ser Asp Lys Val Ile Val Thr Gly Asn Thr Val Ile Asp Ala 
                165                 170                 175     


Leu Met Val Ser Leu Glu Lys Leu Lys Ile Thr Thr Ile Lys Lys Gln 
            180                 185                 190         


Met Glu Gln Ala Phe Pro Phe Ile Gln Asp Asn Ser Lys Val Ile Leu 
        195                 200                 205             


Ile Thr Ala His Arg Arg Glu Asn His Gly Glu Gly Ile Lys Asn Ile 
    210                 215                 220                 


Gly Leu Ser Ile Leu Glu Leu Ala Lys Lys Tyr Pro Thr Phe Ser Phe 
225                 230                 235                 240 


Val Ile Pro Leu His Leu Asn Pro Asn Val Arg Lys Pro Ile Gln Asp 
                245                 250                 255     


Leu Leu Ser Ser Val His Asn Val His Leu Ile Glu Pro Gln Glu Tyr 
            260                 265                 270         


Leu Pro Phe Val Tyr Leu Met Ser Lys Ser His Ile Ile Leu Ser Asp 
        275                 280                 285             


Ser Gly Gly Ile Gln Glu Glu Ala Pro Ser Leu Gly Lys Pro Val Leu 
    290                 295                 300                 


Val Leu Arg Asp Thr Thr Glu Arg Pro Glu Ala Val Ala Ala Gly Thr 
305                 310                 315                 320 


Val Lys Leu Val Gly Ser Glu Thr Gln Asn Ile Ile Glu Ser Phe Thr 
                325                 330                 335     


Gln Leu Ile Glu Tyr Pro Glu Tyr Tyr Glu Lys Met Ala Asn Ile Glu 
            340                 345                 350         


Asn Pro Tyr Gly Ile Gly Asn Ala Ser Lys Ile Ile Val Glu Thr Leu 
        355                 360                 365             


Leu Lys Asn Arg 
    370         


<210>  13
<211>  3192
<212>  DNA
<213>  Neisseria meningitidis

<400>  13
atggctagct ggagccaccc gcagttcgaa aaaggcgccc tggttccgcg tggatccgct     60

gttattatat ttgttaacgg aattcgggct gtaaatggcc ttgttaaatc atctatcaat    120

actgcaaacg cttttgctga agaaggactg gatgttcatt taattaattt tgttggcaat    180

attactggag cagagcattt atacccccca ttccacttac atcccaatgt caaaacctcc    240

agcatcatag atttatttaa tgacattcca gaaaatgtta gctgccgaaa tactcctttt    300

tattctattc atcaacaatt cttcaaagct gaatatagtg cccactataa gcatgttttg    360

atgaaaattg aatctttatt atctgcagaa gatagcatta tcttcactca tcctcttcaa    420

ctggaaatgt atcgtttagc gaataatgat atcaagtcaa aagccaaact aattgtacaa    480

attcatggta attatatgga agaaatccat aactatgaaa ttttggcacg aaatatcgat    540

tatgttgact atcttcaaac ggtatctgat gaaatgctgg aagaaatgca ttcccatttc    600

aaaatcaaaa aagacaaatt agtttttatt ccaaacatca cttatcccat ttcattagaa    660

aaaaaagaag ctgatttctt tattaaggat aatgaagaca tcgataatgc tcagaaattt    720

aaacgtatct ctattgttgg cagcattcag ccaagaaaaa accaattgga tgccattaaa    780

atcatcaata aaattaaaaa tgaaaattac attttacaga tatatggcaa atctattaat    840

aaagattact ttgaattaat taaaaaatat attaaagaca ataagttaca aaaccgtatc    900

ttattcaaag gtgaatcttc cgagcaggaa atttatgaaa atacagatat cctgatcatg    960

acatcagaaa gtgagggatt tccatatata tttatggaag gcatggtgta tgatattcca   1020

atcgttgtat atgattttaa atatggagcg aatgattaca gtaactataa tgaaaatggt   1080

tgtgttttta aaactggtga tatttctgga atggcaaaaa aaataattga gctattaaat   1140

aacccagaaa aatataaaga attagttcaa tataatcaca atcgcttctt aaaagaatat   1200

gcaaaagatg tggttatggc taaatatttc actattcttc cgcgcagctt taataacgta   1260

tcattatcgt ctgctttcag ccgaaaagaa ttggacgaat tccaaaatat tactttttct   1320

attgaagatt ctaatgattt agctcatatt tggaatttcg agctaaccaa tcctgcacaa   1380

aatatgaatt tttttgcttt agttggcaag cgaaaatttc caatggatgc tcatatccaa   1440

ggaacacagt gtacgattaa gatagctcat aaaaagacag ggaatttatt gtcgctttta   1500

ctaaaaaaac gaaatcagtt gaatttatca aggggatata ccttaattgc agaagataat   1560

agctatgaaa aatatattgg agcaatatct aataaaggta actttgaaat tattgcaaat   1620

aaaaagagct cattagttac tataaacaaa agtaccttag agttgcatga gattccccat   1680

gaactacatc agaataaatt actgattgct ttacccaaca tgcaaacgcc tctaaaaatt   1740

actgatgata atttaatacc tatccaagcc tccataaaat tagaaaagat tggaaatact   1800

tattacccat gtttcttgcc atctggcata tttaataata tctgcttaga ttacggtgaa   1860

gaatccaaaa ttattaattt tagtaaatat tcttataaat atatctatga ctcaattcgt   1920

catattgagc aacatacaga tatatcggat attatcgttt gcaatgttta ttcttgggaa   1980

cttattcgtg cctcagttat tgagagcctt atggaattta ccggaaaatg ggaaaaacac   2040

tttcagactt ctcctaaaat tgattatcga tttgatcatg aaggtaagcg ttcgatggat   2100

gatgtctttt cagaagaaac atttattatg gaatttccgc gtaaaaatgg tatagataag   2160

aaaacagcag ccttccaaaa tataccaaac agtattgtaa tggagtatcc gcagaccaat   2220

ggttacagta tgcgcagtca ttcactgaaa agtaatgtag ttgcggcaaa acattttctt   2280

gaaaaattaa ataaaattaa ggtagatatt aaatttaaaa agcatgacct tgcaaacatc   2340

aaaaaaatga atcgaattat ttatgagcat ttaggcatta acataaatat cgaagcattt   2400

ctaaaaccac gattagaaaa atttaagcgt gaagaaaaat attttcatga tttcttcaaa   2460

agaaataatt ttaaagaggt aatttttcca agcacttatt ggaatccagg tattatttgt   2520

gctgcacata aacaaggtat taaggtatct gatattcaat atgctgccat tactccttat   2580

catcctgcgt attttaaatc accaaaatca cattacgttg ctgataaatt gttcttatgg   2640

tctgaatatt ggaatcatga gcttttacca aatccaacac gagagattgg ttctggtgcc   2700

gcatattggt atgcattaga tgatgtgaga ttttcagaaa aactgaatta tgactatatc   2760

tttctatctc aaagtaggat ttcttcgcgc ttgcttagtt ttgcaattga gtttgcatta   2820

aaaaatcctc aactacagct tttattttct aagcatccag atgaaaatat agatttaaag   2880

aacagaatta ttcctgataa tcttataatc tccacggaat cttctataca aggcatcaat   2940

gaatctcgcg ttgctgtagg tgtttattca actagcttat ttgaggcatt agcatgcggc   3000

aaacaaactt ttgttgttaa atatccggga tatgaaatta tgtcaaatga aatagattca   3060

gggttattct ttgcagtaga aacacctgaa gaaatgcttg agaaaacaag cccgaattgg   3120

gtggctgtgg cagatattga aaaccagttt tttggccaag aaaaactcga gcaccaccac   3180

caccaccact ga                                                       3192


<210>  14
<211>  1063
<212>  PRT
<213>  Neisseria meningitidis

<400>  14

Met Ala Ser Trp Ser His Pro Gln Phe Glu Lys Gly Ala Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser Ala Val Ile Ile Phe Val Asn Gly Ile Arg Ala Val Asn 
            20                  25                  30          


Gly Leu Val Lys Ser Ser Ile Asn Thr Ala Asn Ala Phe Ala Glu Glu 
        35                  40                  45              


Gly Leu Asp Val His Leu Ile Asn Phe Val Gly Asn Ile Thr Gly Ala 
    50                  55                  60                  


Glu His Leu Tyr Pro Pro Phe His Leu His Pro Asn Val Lys Thr Ser 
65                  70                  75                  80  


Ser Ile Ile Asp Leu Phe Asn Asp Ile Pro Glu Asn Val Ser Cys Arg 
                85                  90                  95      


Asn Thr Pro Phe Tyr Ser Ile His Gln Gln Phe Phe Lys Ala Glu Tyr 
            100                 105                 110         


Ser Ala His Tyr Lys His Val Leu Met Lys Ile Glu Ser Leu Leu Ser 
        115                 120                 125             


Ala Glu Asp Ser Ile Ile Phe Thr His Pro Leu Gln Leu Glu Met Tyr 
    130                 135                 140                 


Arg Leu Ala Asn Asn Asp Ile Lys Ser Lys Ala Lys Leu Ile Val Gln 
145                 150                 155                 160 


Ile His Gly Asn Tyr Met Glu Glu Ile His Asn Tyr Glu Ile Leu Ala 
                165                 170                 175     


Arg Asn Ile Asp Tyr Val Asp Tyr Leu Gln Thr Val Ser Asp Glu Met 
            180                 185                 190         


Leu Glu Glu Met His Ser His Phe Lys Ile Lys Lys Asp Lys Leu Val 
        195                 200                 205             


Phe Ile Pro Asn Ile Thr Tyr Pro Ile Ser Leu Glu Lys Lys Glu Ala 
    210                 215                 220                 


Asp Phe Phe Ile Lys Asp Asn Glu Asp Ile Asp Asn Ala Gln Lys Phe 
225                 230                 235                 240 


Lys Arg Ile Ser Ile Val Gly Ser Ile Gln Pro Arg Lys Asn Gln Leu 
                245                 250                 255     


Asp Ala Ile Lys Ile Ile Asn Lys Ile Lys Asn Glu Asn Tyr Ile Leu 
            260                 265                 270         


Gln Ile Tyr Gly Lys Ser Ile Asn Lys Asp Tyr Phe Glu Leu Ile Lys 
        275                 280                 285             


Lys Tyr Ile Lys Asp Asn Lys Leu Gln Asn Arg Ile Leu Phe Lys Gly 
    290                 295                 300                 


Glu Ser Ser Glu Gln Glu Ile Tyr Glu Asn Thr Asp Ile Leu Ile Met 
305                 310                 315                 320 


Thr Ser Glu Ser Glu Gly Phe Pro Tyr Ile Phe Met Glu Gly Met Val 
                325                 330                 335     


Tyr Asp Ile Pro Ile Val Val Tyr Asp Phe Lys Tyr Gly Ala Asn Asp 
            340                 345                 350         


Tyr Ser Asn Tyr Asn Glu Asn Gly Cys Val Phe Lys Thr Gly Asp Ile 
        355                 360                 365             


Ser Gly Met Ala Lys Lys Ile Ile Glu Leu Leu Asn Asn Pro Glu Lys 
    370                 375                 380                 


Tyr Lys Glu Leu Val Gln Tyr Asn His Asn Arg Phe Leu Lys Glu Tyr 
385                 390                 395                 400 


Ala Lys Asp Val Val Met Ala Lys Tyr Phe Thr Ile Leu Pro Arg Ser 
                405                 410                 415     


Phe Asn Asn Val Ser Leu Ser Ser Ala Phe Ser Arg Lys Glu Leu Asp 
            420                 425                 430         


Glu Phe Gln Asn Ile Thr Phe Ser Ile Glu Asp Ser Asn Asp Leu Ala 
        435                 440                 445             


His Ile Trp Asn Phe Glu Leu Thr Asn Pro Ala Gln Asn Met Asn Phe 
    450                 455                 460                 


Phe Ala Leu Val Gly Lys Arg Lys Phe Pro Met Asp Ala His Ile Gln 
465                 470                 475                 480 


Gly Thr Gln Cys Thr Ile Lys Ile Ala His Lys Lys Thr Gly Asn Leu 
                485                 490                 495     


Leu Ser Leu Leu Leu Lys Lys Arg Asn Gln Leu Asn Leu Ser Arg Gly 
            500                 505                 510         


Tyr Thr Leu Ile Ala Glu Asp Asn Ser Tyr Glu Lys Tyr Ile Gly Ala 
        515                 520                 525             


Ile Ser Asn Lys Gly Asn Phe Glu Ile Ile Ala Asn Lys Lys Ser Ser 
    530                 535                 540                 


Leu Val Thr Ile Asn Lys Ser Thr Leu Glu Leu His Glu Ile Pro His 
545                 550                 555                 560 


Glu Leu His Gln Asn Lys Leu Leu Ile Ala Leu Pro Asn Met Gln Thr 
                565                 570                 575     


Pro Leu Lys Ile Thr Asp Asp Asn Leu Ile Pro Ile Gln Ala Ser Ile 
            580                 585                 590         


Lys Leu Glu Lys Ile Gly Asn Thr Tyr Tyr Pro Cys Phe Leu Pro Ser 
        595                 600                 605             


Gly Ile Phe Asn Asn Ile Cys Leu Asp Tyr Gly Glu Glu Ser Lys Ile 
    610                 615                 620                 


Ile Asn Phe Ser Lys Tyr Ser Tyr Lys Tyr Ile Tyr Asp Ser Ile Arg 
625                 630                 635                 640 


His Ile Glu Gln His Thr Asp Ile Ser Asp Ile Ile Val Cys Asn Val 
                645                 650                 655     


Tyr Ser Trp Glu Leu Ile Arg Ala Ser Val Ile Glu Ser Leu Met Glu 
            660                 665                 670         


Phe Thr Gly Lys Trp Glu Lys His Phe Gln Thr Ser Pro Lys Ile Asp 
        675                 680                 685             


Tyr Arg Phe Asp His Glu Gly Lys Arg Ser Met Asp Asp Val Phe Ser 
    690                 695                 700                 


Glu Glu Thr Phe Ile Met Glu Phe Pro Arg Lys Asn Gly Ile Asp Lys 
705                 710                 715                 720 


Lys Thr Ala Ala Phe Gln Asn Ile Pro Asn Ser Ile Val Met Glu Tyr 
                725                 730                 735     


Pro Gln Thr Asn Gly Tyr Ser Met Arg Ser His Ser Leu Lys Ser Asn 
            740                 745                 750         


Val Val Ala Ala Lys His Phe Leu Glu Lys Leu Asn Lys Ile Lys Val 
        755                 760                 765             


Asp Ile Lys Phe Lys Lys His Asp Leu Ala Asn Ile Lys Lys Met Asn 
    770                 775                 780                 


Arg Ile Ile Tyr Glu His Leu Gly Ile Asn Ile Asn Ile Glu Ala Phe 
785                 790                 795                 800 


Leu Lys Pro Arg Leu Glu Lys Phe Lys Arg Glu Glu Lys Tyr Phe His 
                805                 810                 815     


Asp Phe Phe Lys Arg Asn Asn Phe Lys Glu Val Ile Phe Pro Ser Thr 
            820                 825                 830         


Tyr Trp Asn Pro Gly Ile Ile Cys Ala Ala His Lys Gln Gly Ile Lys 
        835                 840                 845             


Val Ser Asp Ile Gln Tyr Ala Ala Ile Thr Pro Tyr His Pro Ala Tyr 
    850                 855                 860                 


Phe Lys Ser Pro Lys Ser His Tyr Val Ala Asp Lys Leu Phe Leu Trp 
865                 870                 875                 880 


Ser Glu Tyr Trp Asn His Glu Leu Leu Pro Asn Pro Thr Arg Glu Ile 
                885                 890                 895     


Gly Ser Gly Ala Ala Tyr Trp Tyr Ala Leu Asp Asp Val Arg Phe Ser 
            900                 905                 910         


Glu Lys Leu Asn Tyr Asp Tyr Ile Phe Leu Ser Gln Ser Arg Ile Ser 
        915                 920                 925             


Ser Arg Leu Leu Ser Phe Ala Ile Glu Phe Ala Leu Lys Asn Pro Gln 
    930                 935                 940                 


Leu Gln Leu Leu Phe Ser Lys His Pro Asp Glu Asn Ile Asp Leu Lys 
945                 950                 955                 960 


Asn Arg Ile Ile Pro Asp Asn Leu Ile Ile Ser Thr Glu Ser Ser Ile 
                965                 970                 975     


Gln Gly Ile Asn Glu Ser Arg Val Ala Val Gly Val Tyr Ser Thr Ser 
            980                 985                 990         


Leu Phe Glu Ala Leu Ala Cys Gly  Lys Gln Thr Phe Val  Val Lys Tyr 
        995                 1000                 1005             


Pro Gly  Tyr Glu Ile Met Ser  Asn Glu Ile Asp Ser  Gly Leu Phe 
    1010                 1015                 1020             


Phe Ala  Val Glu Thr Pro Glu  Glu Met Leu Glu Lys  Thr Ser Pro 
    1025                 1030                 1035             


Asn Trp  Val Ala Val Ala Asp  Ile Glu Asn Gln Phe  Phe Gly Gln 
    1040                 1045                 1050             


Glu Lys  Leu Glu His His His  His His His 
    1055                 1060             


<210>  15
<211>  3192
<212>  DNA
<213>  Neisseria meningitidis

<400>  15
atggctagct ggagccaccc gcagttcgaa aaaggcgccc tggttccgcg tggatccgct     60

gttattatat ttgttaacgg aattcgggct gtaaatggcc ttgttaaatc atctatcaat    120

actgcaaacg cttttgctga agaaggactg gatgttcatt taattaattt tgttggcaat    180

attactggag cagagcattt atccccccca ttccacttac atcccaatgt caaaacctcc    240

agcatcatag atttatttaa tgacattcca gaaaatgtta gctgccgaaa tattcctttt    300

tattctatcc atcaacaatt cttcaaagcc gaatacagtg cccactataa gcatgttttg    360

atgaaaattg aatctttatt atctgaagaa gatagcatta tcttcactca tcctcttcaa    420

ctggaaatgt atcgtttagc gaataataat attaagtcaa aagccaagct aattgtacaa    480

attcatggta actatatgga agaaatccat aactatgaaa tttgggcacg aaatatcgat    540

tatgttgatt atcttcaaac ggtatctgat gaaatgctgg aagaaatgca ttcccatttc    600

aaaatcaaaa aagacaaatt agtttttatt ccaaacatca cttatcccat ttcattagaa    660

aaaaaagaag ctgatttctt tattaaggat aatgaagaca ttgataatgc tcagaaattt    720

aaacgtatct ctattgttgg cagtattcag ccaagaaaaa accaattgga tgccattaaa    780

atcatcaata aaattaaaaa tgaaaattac attttacaga tatatggcaa atctattaat    840

aaagattact ttgaattaat taaaaaatat attaaagaca ataagttaca aaaccgtatc    900

ttattcaaag gtgaatcttc cgagcaggaa atttatgaga atacagatat cctaatcatg    960

acatctcaaa gcgaaggctt tggttatata tttctagagg gtatggtgta cgatatccct   1020

atccttgcct ataattttaa atatggagcg aatgatttta gcaattataa tgaaaacgct   1080

tcagttttta aaactggtga tatttctgga atggcaaaaa aaataattga gctattaaat   1140

aacccagaaa aatataaaga attagttcaa tataatcaca atcgcttctt aaaagaatat   1200

gcaaaagatg tggttatggc taaatatttc actattcttc cgcgcagctt taataacgta   1260

tcattatcgt ctgctttcag ccgaaaagaa ttggacgaat tccaaaatat tactttttct   1320

attgaagatt ctaatgattt agctcatatt tggaatttcg agctaaccaa tcctgcacaa   1380

aatatgaatt tttttgcttt agttggcaag cgaaaatttc caatggatgc tcatatccaa   1440

ggaacacagt gtacgattaa gatagctcat aaaaagacag ggaatttatt gtcgctttta   1500

ctaaaaaaac gaaatcagtt gaatttatca aggggatata ccttaattgc agaagataat   1560

agctatgaaa aatatattgg agcaatatct aataaaggta actttgaaat tattgcaaat   1620

aaaaagaact cattagttac tataaacaaa agtaccttag agttgcatga gattccccat   1680

gaactacatc agaataaatt actgattgct ttacccaaca tgcaaacgcc tctaaaaatt   1740

actgatgata atttaatacc tatccaagcc tccataaaat tagaaaagat tggaaatact   1800

tattacccat gtttcttgcc atctggcata tttaataata tctgcttaga ttacggtgaa   1860

gaatccaaaa ttattaattt tagtaaatat tcttataaat atatctatga ctcaattcgt   1920

catattgagc aacatacaga tatatcggat attatcgttt gcaatgttta ttcttgggaa   1980

cttattcgtg cctcagttat tgagagcctt atggaattta ccggaaaatg ggaaaaacac   2040

tttcagactt ctcctaaaat tgattatcga tttgatcatg aaggtaagcg ttcgatggat   2100

gatgtctttt cagaagaaac atttattatg gaatttccgc gtaaaaatgg tatagataag   2160

aaaacagcag ccttccaaaa tataccaaac agtattgtaa tggagtatcc gcagaccaat   2220

ggttacagta tgcgcagtca ttcactgaaa agtaatgtag ttgcggcaaa acattttctt   2280

gaaaaattaa ataaaattaa ggtagatatt aaatttaaaa agcatgacct tgcaaacatc   2340

aaaaaaatga atcgaattat ttatgagcat ttaggcatta acataaatat cgaagcattt   2400

ctaaaaccac gattagaaaa atttaagcgt gaagaaaaat attttcatga tttcttcaaa   2460

agaaataatt ttaaagaggt aatttttcca agcacttatt ggaatccagg tattatttgt   2520

gctgcacata aacaaggtat taaggtatct gatattcaat atgctgccat tactccttat   2580

catcctgcgt attttaaatc accaaaatca cattacgttg ctgataaatt gttcttatgg   2640

tctgaatatt ggaatcatga gcttttacca aatccaacac gagagattgg ttctggtgcc   2700

gcatattggt atgcattaga tgatgtgaga ttttcagaaa aactgaatta tgactatatc   2760

tttctatctc aaagtaggat ttcttcgcgc ttgcttagtt ttgcaattga gtttgcatta   2820

aaaaatcctc aactacagct tttattttct aagcatctag atgaaaatat agatttaaag   2880

aacagaatta ttcctgataa tcttataatc tccacggaat cttctataca aggcatcaat   2940

gaatctcgcg ttgctgtagg tgtttattca actagcttat ttgaggcatt agcatgcggc   3000

aaacaaactt ttgttgttaa atatccggga tatgaaatta tgtcaaatga aatagattca   3060

gggttattct ttgcagtaga aacacctgaa gaaatgcttg agaaaacaag cccgaattgg   3120

gtggctgtgg cagatattga aaaccagttt tttggccaag aaaaactcga gcaccaccac   3180

caccaccact ga                                                       3192


<210>  16
<211>  1063
<212>  PRT
<213>  Neisseria meningitidis

<400>  16

Met Ala Ser Trp Ser His Pro Gln Phe Glu Lys Gly Ala Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser Ala Val Ile Ile Phe Val Asn Gly Ile Arg Ala Val Asn 
            20                  25                  30          


Gly Leu Val Lys Ser Ser Ile Asn Thr Ala Asn Ala Phe Ala Glu Glu 
        35                  40                  45              


Gly Leu Asp Val His Leu Ile Asn Phe Val Gly Asn Ile Thr Gly Ala 
    50                  55                  60                  


Glu His Leu Ser Pro Pro Phe His Leu His Pro Asn Val Lys Thr Ser 
65                  70                  75                  80  


Ser Ile Ile Asp Leu Phe Asn Asp Ile Pro Glu Asn Val Ser Cys Arg 
                85                  90                  95      


Asn Ile Pro Phe Tyr Ser Ile His Gln Gln Phe Phe Lys Ala Glu Tyr 
            100                 105                 110         


Ser Ala His Tyr Lys His Val Leu Met Lys Ile Glu Ser Leu Leu Ser 
        115                 120                 125             


Glu Glu Asp Ser Ile Ile Phe Thr His Pro Leu Gln Leu Glu Met Tyr 
    130                 135                 140                 


Arg Leu Ala Asn Asn Asn Ile Lys Ser Lys Ala Lys Leu Ile Val Gln 
145                 150                 155                 160 


Ile His Gly Asn Tyr Met Glu Glu Ile His Asn Tyr Glu Ile Trp Ala 
                165                 170                 175     


Arg Asn Ile Asp Tyr Val Asp Tyr Leu Gln Thr Val Ser Asp Glu Met 
            180                 185                 190         


Leu Glu Glu Met His Ser His Phe Lys Ile Lys Lys Asp Lys Leu Val 
        195                 200                 205             


Phe Ile Pro Asn Ile Thr Tyr Pro Ile Ser Leu Glu Lys Lys Glu Ala 
    210                 215                 220                 


Asp Phe Phe Ile Lys Asp Asn Glu Asp Ile Asp Asn Ala Gln Lys Phe 
225                 230                 235                 240 


Lys Arg Ile Ser Ile Val Gly Ser Ile Gln Pro Arg Lys Asn Gln Leu 
                245                 250                 255     


Asp Ala Ile Lys Ile Ile Asn Lys Ile Lys Asn Glu Asn Tyr Ile Leu 
            260                 265                 270         


Gln Ile Tyr Gly Lys Ser Ile Asn Lys Asp Tyr Phe Glu Leu Ile Lys 
        275                 280                 285             


Lys Tyr Ile Lys Asp Asn Lys Leu Gln Asn Arg Ile Leu Phe Lys Gly 
    290                 295                 300                 


Glu Ser Ser Glu Gln Glu Ile Tyr Glu Asn Thr Asp Ile Leu Ile Met 
305                 310                 315                 320 


Thr Ser Gln Ser Glu Gly Phe Gly Tyr Ile Phe Leu Glu Gly Met Val 
                325                 330                 335     


Tyr Asp Ile Pro Ile Leu Ala Tyr Asn Phe Lys Tyr Gly Ala Asn Asp 
            340                 345                 350         


Phe Ser Asn Tyr Asn Glu Asn Ala Ser Val Phe Lys Thr Gly Asp Ile 
        355                 360                 365             


Ser Gly Met Ala Lys Lys Ile Ile Glu Leu Leu Asn Asn Pro Glu Lys 
    370                 375                 380                 


Tyr Lys Glu Leu Val Gln Tyr Asn His Asn Arg Phe Leu Lys Glu Tyr 
385                 390                 395                 400 


Ala Lys Asp Val Val Met Ala Lys Tyr Phe Thr Ile Leu Pro Arg Ser 
                405                 410                 415     


Phe Asn Asn Val Ser Leu Ser Ser Ala Phe Ser Arg Lys Glu Leu Asp 
            420                 425                 430         


Glu Phe Gln Asn Ile Thr Phe Ser Ile Glu Asp Ser Asn Asp Leu Ala 
        435                 440                 445             


His Ile Trp Asn Phe Glu Leu Thr Asn Pro Ala Gln Asn Met Asn Phe 
    450                 455                 460                 


Phe Ala Leu Val Gly Lys Arg Lys Phe Pro Met Asp Ala His Ile Gln 
465                 470                 475                 480 


Gly Thr Gln Cys Thr Ile Lys Ile Ala His Lys Lys Thr Gly Asn Leu 
                485                 490                 495     


Leu Ser Leu Leu Leu Lys Lys Arg Asn Gln Leu Asn Leu Ser Arg Gly 
            500                 505                 510         


Tyr Thr Leu Ile Ala Glu Asp Asn Ser Tyr Glu Lys Tyr Ile Gly Ala 
        515                 520                 525             


Ile Ser Asn Lys Gly Asn Phe Glu Ile Ile Ala Asn Lys Lys Asn Ser 
    530                 535                 540                 


Leu Val Thr Ile Asn Lys Ser Thr Leu Glu Leu His Glu Ile Pro His 
545                 550                 555                 560 


Glu Leu His Gln Asn Lys Leu Leu Ile Ala Leu Pro Asn Met Gln Thr 
                565                 570                 575     


Pro Leu Lys Ile Thr Asp Asp Asn Leu Ile Pro Ile Gln Ala Ser Ile 
            580                 585                 590         


Lys Leu Glu Lys Ile Gly Asn Thr Tyr Tyr Pro Cys Phe Leu Pro Ser 
        595                 600                 605             


Gly Ile Phe Asn Asn Ile Cys Leu Asp Tyr Gly Glu Glu Ser Lys Ile 
    610                 615                 620                 


Ile Asn Phe Ser Lys Tyr Ser Tyr Lys Tyr Ile Tyr Asp Ser Ile Arg 
625                 630                 635                 640 


His Ile Glu Gln His Thr Asp Ile Ser Asp Ile Ile Val Cys Asn Val 
                645                 650                 655     


Tyr Ser Trp Glu Leu Ile Arg Ala Ser Val Ile Glu Ser Leu Met Glu 
            660                 665                 670         


Phe Thr Gly Lys Trp Glu Lys His Phe Gln Thr Ser Pro Lys Ile Asp 
        675                 680                 685             


Tyr Arg Phe Asp His Glu Gly Lys Arg Ser Met Asp Asp Val Phe Ser 
    690                 695                 700                 


Glu Glu Thr Phe Ile Met Glu Phe Pro Arg Lys Asn Gly Ile Asp Lys 
705                 710                 715                 720 


Lys Thr Ala Ala Phe Gln Asn Ile Pro Asn Ser Ile Val Met Glu Tyr 
                725                 730                 735     


Pro Gln Thr Asn Gly Tyr Ser Met Arg Ser His Ser Leu Lys Ser Asn 
            740                 745                 750         


Val Val Ala Ala Lys His Phe Leu Glu Lys Leu Asn Lys Ile Lys Val 
        755                 760                 765             


Asp Ile Lys Phe Lys Lys His Asp Leu Ala Asn Ile Lys Lys Met Asn 
    770                 775                 780                 


Arg Ile Ile Tyr Glu His Leu Gly Ile Asn Ile Asn Ile Glu Ala Phe 
785                 790                 795                 800 


Leu Lys Pro Arg Leu Glu Lys Phe Lys Arg Glu Glu Lys Tyr Phe His 
                805                 810                 815     


Asp Phe Phe Lys Arg Asn Asn Phe Lys Glu Val Ile Phe Pro Ser Thr 
            820                 825                 830         


Tyr Trp Asn Pro Gly Ile Ile Cys Ala Ala His Lys Gln Gly Ile Lys 
        835                 840                 845             


Val Ser Asp Ile Gln Tyr Ala Ala Ile Thr Pro Tyr His Pro Ala Tyr 
    850                 855                 860                 


Phe Lys Ser Pro Lys Ser His Tyr Val Ala Asp Lys Leu Phe Leu Trp 
865                 870                 875                 880 


Ser Glu Tyr Trp Asn His Glu Leu Leu Pro Asn Pro Thr Arg Glu Ile 
                885                 890                 895     


Gly Ser Gly Ala Ala Tyr Trp Tyr Ala Leu Asp Asp Val Arg Phe Ser 
            900                 905                 910         


Glu Lys Leu Asn Tyr Asp Tyr Ile Phe Leu Ser Gln Ser Arg Ile Ser 
        915                 920                 925             


Ser Arg Leu Leu Ser Phe Ala Ile Glu Phe Ala Leu Lys Asn Pro Gln 
    930                 935                 940                 


Leu Gln Leu Leu Phe Ser Lys His Leu Asp Glu Asn Ile Asp Leu Lys 
945                 950                 955                 960 


Asn Arg Ile Ile Pro Asp Asn Leu Ile Ile Ser Thr Glu Ser Ser Ile 
                965                 970                 975     


Gln Gly Ile Asn Glu Ser Arg Val Ala Val Gly Val Tyr Ser Thr Ser 
            980                 985                 990         


Leu Phe Glu Ala Leu Ala Cys Gly  Lys Gln Thr Phe Val  Val Lys Tyr 
        995                 1000                 1005             


Pro Gly  Tyr Glu Ile Met Ser  Asn Glu Ile Asp Ser  Gly Leu Phe 
    1010                 1015                 1020             


Phe Ala  Val Glu Thr Pro Glu  Glu Met Leu Glu Lys  Thr Ser Pro 
    1025                 1030                 1035             


Asn Trp  Val Ala Val Ala Asp  Ile Glu Asn Gln Phe  Phe Gly Gln 
    1040                 1045                 1050             


Glu Lys  Leu Glu His His His  His His His 
    1055                 1060             


<210>  17
<211>  3138
<212>  DNA
<213>  Neisseria meningitidis

<400>  17
atggctgtta ttatatttgt taacggaatt cgggctgtaa atggccttgt taaatcatct     60

atcaatactg caaacgcttt tgctgaagaa ggactggatg ttcatttaat taattttgtt    120

ggcaatatta ctggagcaga gcatttatac cccccattcc acttacatcc caatgtcaaa    180

acctccagca tcatagattt atttaatgac attccagaaa atgttagctg ccgaaatact    240

cctttttatt ctattcatca acaattcttc aaagctgaat atagtgccca ctataagcat    300

gttttgatga aaattgaatc tttattatct gcagaagata gcattatctt cactcatcct    360

cttcaactgg aaatgtatcg tttagcgaat aatgatatca agtcaaaagc caaactaatt    420

gtacaaattc atggtaatta tatggaagaa atccataact atgaaatttt ggcacgaaat    480

atcgattatg ttgactatct tcaaacggta tctgatgaaa tgctggaaga aatgcattcc    540

catttcaaaa tcaaaaaaga caaattagtt tttattccaa acatcactta tcccatttca    600

ttagaaaaaa aagaagctga tttctttatt aaggataatg aagacatcga taatgctcag    660

aaatttaaac gtatctctat tgttggcagc attcagccaa gaaaaaacca attggatgcc    720

attaaaatca tcaataaaat taaaaatgaa aattacattt tacagatata tggcaaatct    780

attaataaag attactttga attaattaaa aaatatatta aagacaataa gttacaaaac    840

cgtatcttat tcaaaggtga atcttccgag caggaaattt atgaaaatac agatatcctg    900

atcatgacat cagaaagtga gggatttcca tatatattta tggaaggcat ggtgtatgat    960

attccaatcg ttgtatatga ttttaaatat ggagcgaatg attacagtaa ctataatgaa   1020

aatggttgtg tttttaaaac tggtgatatt tctggaatgg caaaaaaaat aattgagcta   1080

ttaaataacc cagaaaaata taaagaatta gttcaatata atcacaatcg cttcttaaaa   1140

gaatatgcaa aagatgtggt tatggctaaa tatttcacta ttcttccgcg cagctttaat   1200

aacgtatcat tatcgtctgc tttcagccga aaagaattgg acgaattcca aaatattact   1260

ttttctattg aagattctaa tgatttagct catatttgga atttcgagct aaccaatcct   1320

gcacaaaata tgaatttttt tgctttagtt ggcaagcgaa aatttccaat ggatgctcat   1380

atccaaggaa cacagtgtac gattaagata gctcataaaa agacagggaa tttattgtcg   1440

cttttactaa aaaaacgaaa tcagttgaat ttatcaaggg gatatacctt aattgcagaa   1500

gataatagct atgaaaaata tattggagca atatctaata aaggtaactt tgaaattatt   1560

gcaaataaaa agagctcatt agttactata aacaaaagta ccttagagtt gcatgagatt   1620

ccccatgaac tacatcagaa taaattactg attgctttac ccaacatgca aacgcctcta   1680

aaaattactg atgataattt aatacctatc caagcctcca taaaattaga aaagattgga   1740

aatacttatt acccatgttt cttgccatct ggcatattta ataatatctg cttagattac   1800

ggtgaagaat ccaaaattat taattttagt aaatattctt ataaatatat ctatgactca   1860

attcgtcata ttgagcaaca tacagatata tcggatatta tcgtttgcaa tgtttattct   1920

tgggaactta ttcgtgcctc agttattgag agccttatgg aatttaccgg aaaatgggaa   1980

aaacactttc agacttctcc taaaattgat tatcgatttg atcatgaagg taagcgttcg   2040

atggatgatg tcttttcaga agaaacattt attatggaat ttccgcgtaa aaatggtata   2100

gataagaaaa cagcagcctt ccaaaatata ccaaacagta ttgtaatgga gtatccgcag   2160

accaatggtt acagtatgcg cagtcattca ctgaaaagta atgtagttgc ggcaaaacat   2220

tttcttgaaa aattaaataa aattaaggta gatattaaat ttaaaaagca tgaccttgca   2280

aacatcaaaa aaatgaatcg aattatttat gagcatttag gcattaacat aaatatcgaa   2340

gcatttctaa aaccacgatt agaaaaattt aagcgtgaag aaaaatattt tcatgatttc   2400

ttcaaaagaa ataattttaa agaggtaatt tttccaagca cttattggaa tccaggtatt   2460

atttgtgctg cacataaaca aggtattaag gtatctgata ttcaatatgc tgccattact   2520

ccttatcatc ctgcgtattt taaatcacca aaatcacatt acgttgctga taaattgttc   2580

ttatggtctg aatattggaa tcatgagctt ttaccaaatc caacacgaga gattggttct   2640

ggtgccgcat attggtatgc attagatgat gtgagatttt cagaaaaact gaattatgac   2700

tatatctttc tatctcaaag taggatttct tcgcgcttgc ttagttttgc aattgagttt   2760

gcattaaaaa atcctcaact acagctttta ttttctaagc atccagatga aaatatagat   2820

ttaaagaaca gaattattcc tgataatctt ataatctcca cggaatcttc tatacaaggc   2880

atcaatgaat ctcgcgttgc tgtaggtgtt tattcaacta gcttatttga ggcattagca   2940

tgcggcaaac aaacttttgt tgttaaatat ccgggatatg aaattatgtc aaatgaaata   3000

gattcagggt tattctttgc agtagaaaca cctgaagaaa tgcttgagaa aacaagcccg   3060

aattgggtgg ctgtggcaga tattgaaaac cagttttttg gccaagaaaa actcgagcac   3120

caccaccacc accactga                                                 3138


<210>  18
<211>  1045
<212>  PRT
<213>  Neisseria meningitidis

<400>  18

Met Ala Val Ile Ile Phe Val Asn Gly Ile Arg Ala Val Asn Gly Leu 
1               5                   10                  15      


Val Lys Ser Ser Ile Asn Thr Ala Asn Ala Phe Ala Glu Glu Gly Leu 
            20                  25                  30          


Asp Val His Leu Ile Asn Phe Val Gly Asn Ile Thr Gly Ala Glu His 
        35                  40                  45              


Leu Tyr Pro Pro Phe His Leu His Pro Asn Val Lys Thr Ser Ser Ile 
    50                  55                  60                  


Ile Asp Leu Phe Asn Asp Ile Pro Glu Asn Val Ser Cys Arg Asn Thr 
65                  70                  75                  80  


Pro Phe Tyr Ser Ile His Gln Gln Phe Phe Lys Ala Glu Tyr Ser Ala 
                85                  90                  95      


His Tyr Lys His Val Leu Met Lys Ile Glu Ser Leu Leu Ser Ala Glu 
            100                 105                 110         


Asp Ser Ile Ile Phe Thr His Pro Leu Gln Leu Glu Met Tyr Arg Leu 
        115                 120                 125             


Ala Asn Asn Asp Ile Lys Ser Lys Ala Lys Leu Ile Val Gln Ile His 
    130                 135                 140                 


Gly Asn Tyr Met Glu Glu Ile His Asn Tyr Glu Ile Leu Ala Arg Asn 
145                 150                 155                 160 


Ile Asp Tyr Val Asp Tyr Leu Gln Thr Val Ser Asp Glu Met Leu Glu 
                165                 170                 175     


Glu Met His Ser His Phe Lys Ile Lys Lys Asp Lys Leu Val Phe Ile 
            180                 185                 190         


Pro Asn Ile Thr Tyr Pro Ile Ser Leu Glu Lys Lys Glu Ala Asp Phe 
        195                 200                 205             


Phe Ile Lys Asp Asn Glu Asp Ile Asp Asn Ala Gln Lys Phe Lys Arg 
    210                 215                 220                 


Ile Ser Ile Val Gly Ser Ile Gln Pro Arg Lys Asn Gln Leu Asp Ala 
225                 230                 235                 240 


Ile Lys Ile Ile Asn Lys Ile Lys Asn Glu Asn Tyr Ile Leu Gln Ile 
                245                 250                 255     


Tyr Gly Lys Ser Ile Asn Lys Asp Tyr Phe Glu Leu Ile Lys Lys Tyr 
            260                 265                 270         


Ile Lys Asp Asn Lys Leu Gln Asn Arg Ile Leu Phe Lys Gly Glu Ser 
        275                 280                 285             


Ser Glu Gln Glu Ile Tyr Glu Asn Thr Asp Ile Leu Ile Met Thr Ser 
    290                 295                 300                 


Glu Ser Glu Gly Phe Pro Tyr Ile Phe Met Glu Gly Met Val Tyr Asp 
305                 310                 315                 320 


Ile Pro Ile Val Val Tyr Asp Phe Lys Tyr Gly Ala Asn Asp Tyr Ser 
                325                 330                 335     


Asn Tyr Asn Glu Asn Gly Cys Val Phe Lys Thr Gly Asp Ile Ser Gly 
            340                 345                 350         


Met Ala Lys Lys Ile Ile Glu Leu Leu Asn Asn Pro Glu Lys Tyr Lys 
        355                 360                 365             


Glu Leu Val Gln Tyr Asn His Asn Arg Phe Leu Lys Glu Tyr Ala Lys 
    370                 375                 380                 


Asp Val Val Met Ala Lys Tyr Phe Thr Ile Leu Pro Arg Ser Phe Asn 
385                 390                 395                 400 


Asn Val Ser Leu Ser Ser Ala Phe Ser Arg Lys Glu Leu Asp Glu Phe 
                405                 410                 415     


Gln Asn Ile Thr Phe Ser Ile Glu Asp Ser Asn Asp Leu Ala His Ile 
            420                 425                 430         


Trp Asn Phe Glu Leu Thr Asn Pro Ala Gln Asn Met Asn Phe Phe Ala 
        435                 440                 445             


Leu Val Gly Lys Arg Lys Phe Pro Met Asp Ala His Ile Gln Gly Thr 
    450                 455                 460                 


Gln Cys Thr Ile Lys Ile Ala His Lys Lys Thr Gly Asn Leu Leu Ser 
465                 470                 475                 480 


Leu Leu Leu Lys Lys Arg Asn Gln Leu Asn Leu Ser Arg Gly Tyr Thr 
                485                 490                 495     


Leu Ile Ala Glu Asp Asn Ser Tyr Glu Lys Tyr Ile Gly Ala Ile Ser 
            500                 505                 510         


Asn Lys Gly Asn Phe Glu Ile Ile Ala Asn Lys Lys Ser Ser Leu Val 
        515                 520                 525             


Thr Ile Asn Lys Ser Thr Leu Glu Leu His Glu Ile Pro His Glu Leu 
    530                 535                 540                 


His Gln Asn Lys Leu Leu Ile Ala Leu Pro Asn Met Gln Thr Pro Leu 
545                 550                 555                 560 


Lys Ile Thr Asp Asp Asn Leu Ile Pro Ile Gln Ala Ser Ile Lys Leu 
                565                 570                 575     


Glu Lys Ile Gly Asn Thr Tyr Tyr Pro Cys Phe Leu Pro Ser Gly Ile 
            580                 585                 590         


Phe Asn Asn Ile Cys Leu Asp Tyr Gly Glu Glu Ser Lys Ile Ile Asn 
        595                 600                 605             


Phe Ser Lys Tyr Ser Tyr Lys Tyr Ile Tyr Asp Ser Ile Arg His Ile 
    610                 615                 620                 


Glu Gln His Thr Asp Ile Ser Asp Ile Ile Val Cys Asn Val Tyr Ser 
625                 630                 635                 640 


Trp Glu Leu Ile Arg Ala Ser Val Ile Glu Ser Leu Met Glu Phe Thr 
                645                 650                 655     


Gly Lys Trp Glu Lys His Phe Gln Thr Ser Pro Lys Ile Asp Tyr Arg 
            660                 665                 670         


Phe Asp His Glu Gly Lys Arg Ser Met Asp Asp Val Phe Ser Glu Glu 
        675                 680                 685             


Thr Phe Ile Met Glu Phe Pro Arg Lys Asn Gly Ile Asp Lys Lys Thr 
    690                 695                 700                 


Ala Ala Phe Gln Asn Ile Pro Asn Ser Ile Val Met Glu Tyr Pro Gln 
705                 710                 715                 720 


Thr Asn Gly Tyr Ser Met Arg Ser His Ser Leu Lys Ser Asn Val Val 
                725                 730                 735     


Ala Ala Lys His Phe Leu Glu Lys Leu Asn Lys Ile Lys Val Asp Ile 
            740                 745                 750         


Lys Phe Lys Lys His Asp Leu Ala Asn Ile Lys Lys Met Asn Arg Ile 
        755                 760                 765             


Ile Tyr Glu His Leu Gly Ile Asn Ile Asn Ile Glu Ala Phe Leu Lys 
    770                 775                 780                 


Pro Arg Leu Glu Lys Phe Lys Arg Glu Glu Lys Tyr Phe His Asp Phe 
785                 790                 795                 800 


Phe Lys Arg Asn Asn Phe Lys Glu Val Ile Phe Pro Ser Thr Tyr Trp 
                805                 810                 815     


Asn Pro Gly Ile Ile Cys Ala Ala His Lys Gln Gly Ile Lys Val Ser 
            820                 825                 830         


Asp Ile Gln Tyr Ala Ala Ile Thr Pro Tyr His Pro Ala Tyr Phe Lys 
        835                 840                 845             


Ser Pro Lys Ser His Tyr Val Ala Asp Lys Leu Phe Leu Trp Ser Glu 
    850                 855                 860                 


Tyr Trp Asn His Glu Leu Leu Pro Asn Pro Thr Arg Glu Ile Gly Ser 
865                 870                 875                 880 


Gly Ala Ala Tyr Trp Tyr Ala Leu Asp Asp Val Arg Phe Ser Glu Lys 
                885                 890                 895     


Leu Asn Tyr Asp Tyr Ile Phe Leu Ser Gln Ser Arg Ile Ser Ser Arg 
            900                 905                 910         


Leu Leu Ser Phe Ala Ile Glu Phe Ala Leu Lys Asn Pro Gln Leu Gln 
        915                 920                 925             


Leu Leu Phe Ser Lys His Pro Asp Glu Asn Ile Asp Leu Lys Asn Arg 
    930                 935                 940                 


Ile Ile Pro Asp Asn Leu Ile Ile Ser Thr Glu Ser Ser Ile Gln Gly 
945                 950                 955                 960 


Ile Asn Glu Ser Arg Val Ala Val Gly Val Tyr Ser Thr Ser Leu Phe 
                965                 970                 975     


Glu Ala Leu Ala Cys Gly Lys Gln Thr Phe Val Val Lys Tyr Pro Gly 
            980                 985                 990         


Tyr Glu Ile Met Ser Asn Glu Ile  Asp Ser Gly Leu Phe  Phe Ala Val 
        995                 1000                 1005             


Glu Thr  Pro Glu Glu Met Leu  Glu Lys Thr Ser Pro  Asn Trp Val 
    1010                 1015                 1020             


Ala Val  Ala Asp Ile Glu Asn  Gln Phe Phe Gly Gln  Glu Lys Leu 
    1025                 1030                 1035             


Glu His  His His His His His  
    1040                 1045 


<210>  19
<211>  2610
<212>  DNA
<213>  Neisseria meningitidis

<400>  19
atgaaaactg aagaaggtaa actggtaatc tggattaacg gcgataaagg ctataacggt     60

ctcgctgaag tcggtaagaa attcgagaaa gataccggaa ttaaagtcac cgttgagcat    120

ccggataaac tggaagagaa attcccacag gttgcggcaa ctggcgatgg ccctgacatt    180

atcttctggg cacacgaccg ctttggtggc tacgctcaat ctggcctgtt ggctgaaatc    240

accccggaca aagcgttcca ggacaagctg tatccgttta cctgggatgc cgtacgttac    300

aacggcaagc tgattgctta cccgatcgct gttgaagcgt tatcgctgat ttataacaaa    360

gatctgctgc cgaacccgcc aaaaacctgg gaagagatcc cggcgctgga taaagaactg    420

aaagcgaaag gtaagagcgc gctgatgttc aacctgcaag aaccgtactt cacctggccg    480

ctgattgctg ctgacggggg ttatgcgttc aagtatgaaa acggcaagta cgacattaaa    540

gacgtgggcg tggataacgc tggcgcgaaa gcgggtctga ccttcctggt tgacctgatt    600

aaaaacaaac acatgaatgc agacaccgat tactccatcg cagaagctgc ctttaataaa    660

ggcgaaacag cgatgaccat caacggcccg tgggcatggt ccaacatcga caccagcaaa    720

gtgaattatg gtgtaacggt actgccgacc ttcaagggtc aaccatccaa accgttcgtt    780

ggcgtgctga gcgcaggtat taacgccgcc agtccgaaca aagagctggc gaaagagttc    840

ctcgaaaact atctgctgac tgatgaaggt ctggaagcgg ttaataaaga caaaccgctg    900

ggtgccgtag cgctgaagtc ttacgaggaa gagttggcga aagatccacg tattgccgcc    960

accatggaaa acgcccagaa aggtgaaatc atgccgaaca tcccgcagat gtccgctttc   1020

tggtatgccg tgcgtactgc ggtgatcaac gccgccagcg gtcgtcagac tgtcgatgaa   1080

gccctgaaag acgcgcagac taattcgagc tcggtacccg gccggggatc cattatgagc   1140

aaaattagca aattggtaac ccacccaaac cttttctttc gagattattt cttaaaaaaa   1200

gcaccgttaa attatggcga aaatattaaa cctttaccag tcgaaacctc ttctcatagc   1260

aaaaaaaata cagcccataa aacacccgta tcatccgacc aaccaattga agatccatac   1320

ccagtaacat ttccaattga tgtagtttat acttgggtag attcagatga tgaaaaattc   1380

aatgaagaac gcctaaagtt tcaaaattca agcacatctg agactctaca aggcaaagca   1440

gaaagcaccg atattgcaag attccaatca cgcgacgaat taaaatattc gattcgaagc   1500

ctgatgaagt atgccccatg ggtaaatcat atttacattg taacaaatgg tcaaatacca   1560

aaatggttag ataccaacaa tacaaaggta acgattatcc ctcactcaac tattatcgac   1620

agtcaatttc tccctacttt taattctcac gtcattgaat cctctctata taaaatccca   1680

ggattatcag agcattacat ttatttcaat gatgatgtca tgctagctag agatttaagc   1740

ccatcttatt tctttacaag cagcggatta gcaaaactgt ttattaccaa ctctcgtcta   1800

ccaaatggct ataagaatgt gaaagacaca ccaacccaat gggcctcaaa aaattcccgt   1860

gagcttttac atgcagaaac aggattttgg gctgaagcca tgtttgcaca tacttttcat   1920

ccacaacgta aaagtgtaca tgaatctatt gaacacctat ggcatgaaca attaaatgtt   1980

tgtcgtcaaa accgtttccg tgatatttca gatattaaca tggcgacatt cctgcaccac   2040

cattttgcca ttttgacagg ccaagctctt gctacacgca ctaaatgtat ttactttaac   2100

gttcgctctc ctcaagcagc tcagcattac aaaacattat tagctcgaaa aggaagcgaa   2160

tacagcccac attctatctg cttaaatgat catacatcga gcaataaaaa tattttatct   2220

aattacgaag ccaaattaca aagcttttta gaaacatact atccagatgt atcagaagca   2280

gaaattctcc ttcctactaa atctgaagta gctgaattag ttaaacataa agattattta   2340

actgtatata ctaaattatt acctattatc aataagcagc tggtcaataa atataataaa   2400

ccttattcat atcttttcta ttatttaggt ttatctgccc ggtttttatt tgaagaaacg   2460

caacaagaac actaccggga aactgctgaa gaaaatttac aaatcttttg tggcctaaac   2520

ccaaaacata cactagccct caaatactta gcggatgtca ccctcacatc acagcctagt   2580

ggacaactcg agcaccacca ccaccaccac                                    2610


<210>  20
<211>  870
<212>  PRT
<213>  Neisseria meningitidis

<400>  20

Met Lys Thr Glu Glu Gly Lys Leu Val Ile Trp Ile Asn Gly Asp Lys 
1               5                   10                  15      


Gly Tyr Asn Gly Leu Ala Glu Val Gly Lys Lys Phe Glu Lys Asp Thr 
            20                  25                  30          


Gly Ile Lys Val Thr Val Glu His Pro Asp Lys Leu Glu Glu Lys Phe 
        35                  40                  45              


Pro Gln Val Ala Ala Thr Gly Asp Gly Pro Asp Ile Ile Phe Trp Ala 
    50                  55                  60                  


His Asp Arg Phe Gly Gly Tyr Ala Gln Ser Gly Leu Leu Ala Glu Ile 
65                  70                  75                  80  


Thr Pro Asp Lys Ala Phe Gln Asp Lys Leu Tyr Pro Phe Thr Trp Asp 
                85                  90                  95      


Ala Val Arg Tyr Asn Gly Lys Leu Ile Ala Tyr Pro Ile Ala Val Glu 
            100                 105                 110         


Ala Leu Ser Leu Ile Tyr Asn Lys Asp Leu Leu Pro Asn Pro Pro Lys 
        115                 120                 125             


Thr Trp Glu Glu Ile Pro Ala Leu Asp Lys Glu Leu Lys Ala Lys Gly 
    130                 135                 140                 


Lys Ser Ala Leu Met Phe Asn Leu Gln Glu Pro Tyr Phe Thr Trp Pro 
145                 150                 155                 160 


Leu Ile Ala Ala Asp Gly Gly Tyr Ala Phe Lys Tyr Glu Asn Gly Lys 
                165                 170                 175     


Tyr Asp Ile Lys Asp Val Gly Val Asp Asn Ala Gly Ala Lys Ala Gly 
            180                 185                 190         


Leu Thr Phe Leu Val Asp Leu Ile Lys Asn Lys His Met Asn Ala Asp 
        195                 200                 205             


Thr Asp Tyr Ser Ile Ala Glu Ala Ala Phe Asn Lys Gly Glu Thr Ala 
    210                 215                 220                 


Met Thr Ile Asn Gly Pro Trp Ala Trp Ser Asn Ile Asp Thr Ser Lys 
225                 230                 235                 240 


Val Asn Tyr Gly Val Thr Val Leu Pro Thr Phe Lys Gly Gln Pro Ser 
                245                 250                 255     


Lys Pro Phe Val Gly Val Leu Ser Ala Gly Ile Asn Ala Ala Ser Pro 
            260                 265                 270         


Asn Lys Glu Leu Ala Lys Glu Phe Leu Glu Asn Tyr Leu Leu Thr Asp 
        275                 280                 285             


Glu Gly Leu Glu Ala Val Asn Lys Asp Lys Pro Leu Gly Ala Val Ala 
    290                 295                 300                 


Leu Lys Ser Tyr Glu Glu Glu Leu Ala Lys Asp Pro Arg Ile Ala Ala 
305                 310                 315                 320 


Thr Met Glu Asn Ala Gln Lys Gly Glu Ile Met Pro Asn Ile Pro Gln 
                325                 330                 335     


Met Ser Ala Phe Trp Tyr Ala Val Arg Thr Ala Val Ile Asn Ala Ala 
            340                 345                 350         


Ser Gly Arg Gln Thr Val Asp Glu Ala Leu Lys Asp Ala Gln Thr Asn 
        355                 360                 365             


Ser Ser Ser Val Pro Gly Arg Gly Ser Ile Met Ser Lys Ile Ser Lys 
    370                 375                 380                 


Leu Val Thr His Pro Asn Leu Phe Phe Arg Asp Tyr Phe Leu Lys Lys 
385                 390                 395                 400 


Ala Pro Leu Asn Tyr Gly Glu Asn Ile Lys Pro Leu Pro Val Glu Thr 
                405                 410                 415     


Ser Ser His Ser Lys Lys Asn Thr Ala His Lys Thr Pro Val Ser Ser 
            420                 425                 430         


Asp Gln Pro Ile Glu Asp Pro Tyr Pro Val Thr Phe Pro Ile Asp Val 
        435                 440                 445             


Val Tyr Thr Trp Val Asp Ser Asp Asp Glu Lys Phe Asn Glu Glu Arg 
    450                 455                 460                 


Leu Lys Phe Gln Asn Ser Ser Thr Ser Glu Thr Leu Gln Gly Lys Ala 
465                 470                 475                 480 


Glu Ser Thr Asp Ile Ala Arg Phe Gln Ser Arg Asp Glu Leu Lys Tyr 
                485                 490                 495     


Ser Ile Arg Ser Leu Met Lys Tyr Ala Pro Trp Val Asn His Ile Tyr 
            500                 505                 510         


Ile Val Thr Asn Gly Gln Ile Pro Lys Trp Leu Asp Thr Asn Asn Thr 
        515                 520                 525             


Lys Val Thr Ile Ile Pro His Ser Thr Ile Ile Asp Ser Gln Phe Leu 
    530                 535                 540                 


Pro Thr Phe Asn Ser His Val Ile Glu Ser Ser Leu Tyr Lys Ile Pro 
545                 550                 555                 560 


Gly Leu Ser Glu His Tyr Ile Tyr Phe Asn Asp Asp Val Met Leu Ala 
                565                 570                 575     


Arg Asp Leu Ser Pro Ser Tyr Phe Phe Thr Ser Ser Gly Leu Ala Lys 
            580                 585                 590         


Leu Phe Ile Thr Asn Ser Arg Leu Pro Asn Gly Tyr Lys Asn Val Lys 
        595                 600                 605             


Asp Thr Pro Thr Gln Trp Ala Ser Lys Asn Ser Arg Glu Leu Leu His 
    610                 615                 620                 


Ala Glu Thr Gly Phe Trp Ala Glu Ala Met Phe Ala His Thr Phe His 
625                 630                 635                 640 


Pro Gln Arg Lys Ser Val His Glu Ser Ile Glu His Leu Trp His Glu 
                645                 650                 655     


Gln Leu Asn Val Cys Arg Gln Asn Arg Phe Arg Asp Ile Ser Asp Ile 
            660                 665                 670         


Asn Met Ala Thr Phe Leu His His His Phe Ala Ile Leu Thr Gly Gln 
        675                 680                 685             


Ala Leu Ala Thr Arg Thr Lys Cys Ile Tyr Phe Asn Val Arg Ser Pro 
    690                 695                 700                 


Gln Ala Ala Gln His Tyr Lys Thr Leu Leu Ala Arg Lys Gly Ser Glu 
705                 710                 715                 720 


Tyr Ser Pro His Ser Ile Cys Leu Asn Asp His Thr Ser Ser Asn Lys 
                725                 730                 735     


Asn Ile Leu Ser Asn Tyr Glu Ala Lys Leu Gln Ser Phe Leu Glu Thr 
            740                 745                 750         


Tyr Tyr Pro Asp Val Ser Glu Ala Glu Ile Leu Leu Pro Thr Lys Ser 
        755                 760                 765             


Glu Val Ala Glu Leu Val Lys His Lys Asp Tyr Leu Thr Val Tyr Thr 
    770                 775                 780                 


Lys Leu Leu Pro Ile Ile Asn Lys Gln Leu Val Asn Lys Tyr Asn Lys 
785                 790                 795                 800 


Pro Tyr Ser Tyr Leu Phe Tyr Tyr Leu Gly Leu Ser Ala Arg Phe Leu 
                805                 810                 815     


Phe Glu Glu Thr Gln Gln Glu His Tyr Arg Glu Thr Ala Glu Glu Asn 
            820                 825                 830         


Leu Gln Ile Phe Cys Gly Leu Asn Pro Lys His Thr Leu Ala Leu Lys 
        835                 840                 845             


Tyr Leu Ala Asp Val Thr Leu Thr Ser Gln Pro Ser Gly Gln Leu Glu 
    850                 855                 860                 


His His His His His His 
865                 870 


<210>  21
<211>  1716
<212>  DNA
<213>  Neisseria meningitidis

<400>  21
atggctagct ggagccaccc gcagttcgaa aaaggcgccc tggttccgcg tggatctttt     60

atacttaata acagaaaatg gcgtaaactt aaaagagacc ctagcgcttt ctttcgagat    120

agtaaattta actttttaag atatttttct gctaaaaaat ttgcaaagaa ttttaaaaat    180

tcatcacata tccataaaac taatataagt aaagctcaat caaatatttc ttcaacctta    240

aaacaaaatc ggaaacaaga tatgttaatt cctattaatt tttttaattt tgaatatata    300

gttaaaaaac ttaacaatca aaacgcaata ggtgtatata ttcttccttc taatcttact    360

cttaagcctg cattatgtat tctagaatca cataaagaag actttttaaa taaatttctt    420

cttactattt cctctgaaaa tttaaagctt caatacaaat ttaatggaca aataaaaaat    480

cctaagtccg taaatgaaat ttggacagat ttatttagca ttgctcatgt tgacatgaaa    540

ctcagcacag atagaacttt aagttcatct atatctcaat tttggttcag attagagttc    600

tgtaaagaag ataaggattt tatcttattt cctacagcta acagatattc tagaaaactt    660

tggaagcact ctattaaaaa taatcaatta tttaaagaag gcatacgaaa ctattcagaa    720

atatcttcat taccctatga agaagatcat aattttgata ttgatttagt atttacttgg    780

gtcaactcag aagataagaa ttggcaagag ttatataaaa aatataagcc cgactttaat    840

agcgatgcaa ccagtacatc aagattcctt agtagagatg aattaaaatt cgcattacgc    900

tcttgggaaa tgaatggatc cttcattcga aaaattttta ttgtctctaa ttgtgctccc    960

ccagcatggc tagatttaaa taaccctaaa attcaatggg tatatcacga agaaattatg   1020

ccacaaagtg cccttcctac ttttagctca catgctattg aaaccagctt gcaccatata   1080

ccaggaatta gtaactattt tatttacagc aatgacgact tcctattaac taaaccattg   1140

aataaagaca atttcttcta ttcgaatggt attgcaaagt taagattaga agcatgggga   1200

aatgttaatg gtgaatgtac tgaaggagaa cctgactact taaatggtgc tcgcaatgcg   1260

aacactctct tagaaaagga atttaaaaaa tttactacta aactacatac tcactcccct   1320

caatccatga gaactgatat tttatttgag atggaaaaaa aatatccaga agagtttaat   1380

agaacactac ataataaatt ccgatcttta gatgatattg cagtaacggg ctatctctat   1440

catcattatg ccctactctc tggacgagca ctacaaagtt ctgacaagac ggaacttgta   1500

cagcaaaatc atgatttcaa aaagaaacta aataatgtag tgaccttaac taaagaaagg   1560

aattttgaca aacttccttt gagcgtatgt atcaacgatg gtgctgatag tcacttgaat   1620

gaagaatgga atgttcaagt tattaagttc ttagaaactc ttttcccatt accatcatca   1680

tttgagaaac tcgagcacca ccaccaccac cactga                             1716


<210>  22
<211>  571
<212>  PRT
<213>  Neisseria meningitidis

<400>  22

Met Ala Ser Trp Ser His Pro Gln Phe Glu Lys Gly Ala Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser Phe Ile Leu Asn Asn Arg Lys Trp Arg Lys Leu Lys Arg 
            20                  25                  30          


Asp Pro Ser Ala Phe Phe Arg Asp Ser Lys Phe Asn Phe Leu Arg Tyr 
        35                  40                  45              


Phe Ser Ala Lys Lys Phe Ala Lys Asn Phe Lys Asn Ser Ser His Ile 
    50                  55                  60                  


His Lys Thr Asn Ile Ser Lys Ala Gln Ser Asn Ile Ser Ser Thr Leu 
65                  70                  75                  80  


Lys Gln Asn Arg Lys Gln Asp Met Leu Ile Pro Ile Asn Phe Phe Asn 
                85                  90                  95      


Phe Glu Tyr Ile Val Lys Lys Leu Asn Asn Gln Asn Ala Ile Gly Val 
            100                 105                 110         


Tyr Ile Leu Pro Ser Asn Leu Thr Leu Lys Pro Ala Leu Cys Ile Leu 
        115                 120                 125             


Glu Ser His Lys Glu Asp Phe Leu Asn Lys Phe Leu Leu Thr Ile Ser 
    130                 135                 140                 


Ser Glu Asn Leu Lys Leu Gln Tyr Lys Phe Asn Gly Gln Ile Lys Asn 
145                 150                 155                 160 


Pro Lys Ser Val Asn Glu Ile Trp Thr Asp Leu Phe Ser Ile Ala His 
                165                 170                 175     


Val Asp Met Lys Leu Ser Thr Asp Arg Thr Leu Ser Ser Ser Ile Ser 
            180                 185                 190         


Gln Phe Trp Phe Arg Leu Glu Phe Cys Lys Glu Asp Lys Asp Phe Ile 
        195                 200                 205             


Leu Phe Pro Thr Ala Asn Arg Tyr Ser Arg Lys Leu Trp Lys His Ser 
    210                 215                 220                 


Ile Lys Asn Asn Gln Leu Phe Lys Glu Gly Ile Arg Asn Tyr Ser Glu 
225                 230                 235                 240 


Ile Ser Ser Leu Pro Tyr Glu Glu Asp His Asn Phe Asp Ile Asp Leu 
                245                 250                 255     


Val Phe Thr Trp Val Asn Ser Glu Asp Lys Asn Trp Gln Glu Leu Tyr 
            260                 265                 270         


Lys Lys Tyr Lys Pro Asp Phe Asn Ser Asp Ala Thr Ser Thr Ser Arg 
        275                 280                 285             


Phe Leu Ser Arg Asp Glu Leu Lys Phe Ala Leu Arg Ser Trp Glu Met 
    290                 295                 300                 


Asn Gly Ser Phe Ile Arg Lys Ile Phe Ile Val Ser Asn Cys Ala Pro 
305                 310                 315                 320 


Pro Ala Trp Leu Asp Leu Asn Asn Pro Lys Ile Gln Trp Val Tyr His 
                325                 330                 335     


Glu Glu Ile Met Pro Gln Ser Ala Leu Pro Thr Phe Ser Ser His Ala 
            340                 345                 350         


Ile Glu Thr Ser Leu His His Ile Pro Gly Ile Ser Asn Tyr Phe Ile 
        355                 360                 365             


Tyr Ser Asn Asp Asp Phe Leu Leu Thr Lys Pro Leu Asn Lys Asp Asn 
    370                 375                 380                 


Phe Phe Tyr Ser Asn Gly Ile Ala Lys Leu Arg Leu Glu Ala Trp Gly 
385                 390                 395                 400 


Asn Val Asn Gly Glu Cys Thr Glu Gly Glu Pro Asp Tyr Leu Asn Gly 
                405                 410                 415     


Ala Arg Asn Ala Asn Thr Leu Leu Glu Lys Glu Phe Lys Lys Phe Thr 
            420                 425                 430         


Thr Lys Leu His Thr His Ser Pro Gln Ser Met Arg Thr Asp Ile Leu 
        435                 440                 445             


Phe Glu Met Glu Lys Lys Tyr Pro Glu Glu Phe Asn Arg Thr Leu His 
    450                 455                 460                 


Asn Lys Phe Arg Ser Leu Asp Asp Ile Ala Val Thr Gly Tyr Leu Tyr 
465                 470                 475                 480 


His His Tyr Ala Leu Leu Ser Gly Arg Ala Leu Gln Ser Ser Asp Lys 
                485                 490                 495     


Thr Glu Leu Val Gln Gln Asn His Asp Phe Lys Lys Lys Leu Asn Asn 
            500                 505                 510         


Val Val Thr Leu Thr Lys Glu Arg Asn Phe Asp Lys Leu Pro Leu Ser 
        515                 520                 525             


Val Cys Ile Asn Asp Gly Ala Asp Ser His Leu Asn Glu Glu Trp Asn 
    530                 535                 540                 


Val Gln Val Ile Lys Phe Leu Glu Thr Leu Phe Pro Leu Pro Ser Ser 
545                 550                 555                 560 


Phe Glu Lys Leu Glu His His His His His His 
                565                 570     


<210>  23
<211>  1197
<212>  DNA
<213>  Neisseria meningitidis

<400>  23
atggctagct ggagccaccc gcagttcgaa aaaggcgccc tggttccgcg tggatccaaa     60

gtcttaaccg tctttggcac tcgccctgaa gctattaaaa tggcgcctgt aattctagag    120

ttacaaaaac ataacacaat tacttcaaaa gtttgcatta ctgcacagca tcgtgaaatg    180

ctagatcagg ttttgagcct attcgaaatc aaagctgatt atgatttaaa tatcatgaaa    240

cccaaccaga gcctacaaga aatcacaaca aatatcatct caagccttac cgatgttctt    300

gaagatttca aacctgactg cgtccttgct cacggagaca ccacaacaac ttttgcagct    360

agccttgctg cattctatca aaaaatacct gttggccaca ttgaagcagg cctgagaact    420

tataatttat actctccttg gccagaggaa gcaaataggc gtttaacaag cgttctaagc    480

cagtggcatt ttgcacctac tgaagattct aaaaataact tactatctga atcaatacct    540

tctgacaaag ttattgttac tggaaatact gtcatagatg cactaatggt atctctagaa    600

aaactaaaaa taactacaat taaaaaacaa atggaacaag cttttccatt tattcaggac    660

aactctaaag taattttaat taccgctcat agaagagaaa atcatgggga aggtattaaa    720

aatattggac tttctatctt agaattagct aaaaaatacc caacattctc ttttgtgatt    780

ccgctccatt taaatcctaa cgttagaaaa ccaattcaag atttattatc ctctgtgcac    840

aatgttcatc ttattgagcc acaagaatac ttaccattcg tatatttaat gtctaaaagc    900

catataatat taagtgattc aggcggcata caagaagaag ctccatccct aggaaaacca    960

gttcttgtat taagagatac tacagaacgt cctgaagctg tagctgcagg aactgtaaaa   1020

ttagtaggtt ctgaaactca aaatattatt gagagcttta cacaactaat tgaataccct   1080

gaatattatg aaaaaatggc taatattgaa aacccttacg ggataggtaa tgcctcaaaa   1140

atcattgtag aaactttatt aaagaataga ctcgagcacc accaccacca ccactga      1197


<210>  24
<211>  398
<212>  PRT
<213>  Neisseria meningitidis

<400>  24

Met Ala Ser Trp Ser His Pro Gln Phe Glu Lys Gly Ala Leu Val Pro 
1               5                   10                  15      


Arg Gly Ser Lys Val Leu Thr Val Phe Gly Thr Arg Pro Glu Ala Ile 
            20                  25                  30          


Lys Met Ala Pro Val Ile Leu Glu Leu Gln Lys His Asn Thr Ile Thr 
        35                  40                  45              


Ser Lys Val Cys Ile Thr Ala Gln His Arg Glu Met Leu Asp Gln Val 
    50                  55                  60                  


Leu Ser Leu Phe Glu Ile Lys Ala Asp Tyr Asp Leu Asn Ile Met Lys 
65                  70                  75                  80  


Pro Asn Gln Ser Leu Gln Glu Ile Thr Thr Asn Ile Ile Ser Ser Leu 
                85                  90                  95      


Thr Asp Val Leu Glu Asp Phe Lys Pro Asp Cys Val Leu Ala His Gly 
            100                 105                 110         


Asp Thr Thr Thr Thr Phe Ala Ala Ser Leu Ala Ala Phe Tyr Gln Lys 
        115                 120                 125             


Ile Pro Val Gly His Ile Glu Ala Gly Leu Arg Thr Tyr Asn Leu Tyr 
    130                 135                 140                 


Ser Pro Trp Pro Glu Glu Ala Asn Arg Arg Leu Thr Ser Val Leu Ser 
145                 150                 155                 160 


Gln Trp His Phe Ala Pro Thr Glu Asp Ser Lys Asn Asn Leu Leu Ser 
                165                 170                 175     


Glu Ser Ile Pro Ser Asp Lys Val Ile Val Thr Gly Asn Thr Val Ile 
            180                 185                 190         


Asp Ala Leu Met Val Ser Leu Glu Lys Leu Lys Ile Thr Thr Ile Lys 
        195                 200                 205             


Lys Gln Met Glu Gln Ala Phe Pro Phe Ile Gln Asp Asn Ser Lys Val 
    210                 215                 220                 


Ile Leu Ile Thr Ala His Arg Arg Glu Asn His Gly Glu Gly Ile Lys 
225                 230                 235                 240 


Asn Ile Gly Leu Ser Ile Leu Glu Leu Ala Lys Lys Tyr Pro Thr Phe 
                245                 250                 255     


Ser Phe Val Ile Pro Leu His Leu Asn Pro Asn Val Arg Lys Pro Ile 
            260                 265                 270         


Gln Asp Leu Leu Ser Ser Val His Asn Val His Leu Ile Glu Pro Gln 
        275                 280                 285             


Glu Tyr Leu Pro Phe Val Tyr Leu Met Ser Lys Ser His Ile Ile Leu 
    290                 295                 300                 


Ser Asp Ser Gly Gly Ile Gln Glu Glu Ala Pro Ser Leu Gly Lys Pro 
305                 310                 315                 320 


Val Leu Val Leu Arg Asp Thr Thr Glu Arg Pro Glu Ala Val Ala Ala 
                325                 330                 335     


Gly Thr Val Lys Leu Val Gly Ser Glu Thr Gln Asn Ile Ile Glu Ser 
            340                 345                 350         


Phe Thr Gln Leu Ile Glu Tyr Pro Glu Tyr Tyr Glu Lys Met Ala Asn 
        355                 360                 365             


Ile Glu Asn Pro Tyr Gly Ile Gly Asn Ala Ser Lys Ile Ile Val Glu 
    370                 375                 380                 


Thr Leu Leu Lys Asn Arg Leu Glu His His His His His His 
385                 390                 395             


<210>  25
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: oligonucleotide"

<400>  25
gcggatccgc tgttattata tttgttaacg                                      30


<210>  26
<211>  30
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: oligonucleotide"

<400>  26
ccgctcgagt ttttcttggc caaaaaactg                                      30


<210>  27
<211>  34
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: oligonucleotide"

<400>  27
gcatctcata tggctgttat tatatttgtt aacg                                 34


<210>  28
<211>  32
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: primer"

<400>  28
gcggatccat tatgagcaaa attagcaaat tg                                   32


<210>  29
<211>  29
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: primer"

<400>  29
ccgctcgagt tgtccactag gctgtgatg                                       29


<210>  30
<211>  31
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: primer"

<400>  30
ctgactccat atgacgaacc cgtccaactc c                                    31


<210>  31
<211>  34
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: primer"

<400>  31
cttagcggcc gcatcaactt tgccgggtca gccg                                 34


<210>  32
<211>  67
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: primer"

<400>  32
cttacatatg catcatcatc atcatcacgc tagcggatcc atgacaacga actatatttt     60

tgtgacc                                                               67


<210>  33
<211>  34
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: primer"

<400>  33
cttagcggcc gcttacttcg cctgacgttt ctgg                                 34


<210>  34
<211>  33
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: primer"

<400>  34
gcagatcttt tatacttaat aacagaaaat ggc                                  33


<210>  35
<211>  32
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: primer"

<400>  35
ccgctcgagt ttctcaaatg atgatggtaa tg                                   32


<210>  36
<211>  29
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: primer"

<400>  36
gcggatccaa agtcttaacc gtctttggc                                       29


<210>  37
<211>  34
<212>  DNA
<213>  artificial sequence

<220>
<221>  source
<223>  /note="Description of artificial sequence: primer"

<400>  37
ccgctcgagt ctattcttta ataaagtttc taca                                 34


