                         SEQUENCE LISTING

<110>  NOX Technologies, Inc.
       Morre, D. James
       Tang, Xiaoyu
       Dick, Sara
       Meadows, Christiaan
       Morre, Dorothy
 
<120>  CLONING AND EXPRESSION OF arNOX PROTEIN TRANSMEMBRANE 9 
       SUPERFAMILY (TM9SF), METHODS AND UTILITY

<130>  92-10 WO

<140>  unassigned
<141>  2010-08-17

<150>  US 61/234,368
<151>  2009-08-17

<160>  17    

<170>  PatentIn version 3.5

<210>  1
<211>  2449
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (349)..(2169)

<400>  1
ggccgcgctg ccgatcgccg ggaggacccc cgcctcgccg aagacgggcg gggcaagccg       60

agcctcacgg ggtccccgga gctgggccgg gcctccagat ggagaaggcg caacggggag      120

ttcttgagta agccagagcg gtgtccagcg cggtgtagcc gcagccgccg ctgtcaggcg      180

cagcaacggg caaccccgta gaagtcggtc ggcaggtcct ctccaacccg ccgctaccgc      240

gccgctgtgg gagagacccc agcaggagcc caaaggcagc tacgggggcg cgaaggccgc      300

tggcgccgcc tcggccagcc cttcccgcgc ggttccactg ccttaagg atg aca gtc       357
                                                     Met Thr Val          
                                                     1                    

gta ggg aac cct cga agt tgg agc tgc cag tgg ttg cca atc ctg ata        405
Val Gly Asn Pro Arg Ser Trp Ser Cys Gln Trp Leu Pro Ile Leu Ile           
    5                   10                  15                            

ctg ttg ctg ggc aca ggc cat ggg cca ggg gtg gaa ggc gtg aca cac        453
Leu Leu Leu Gly Thr Gly His Gly Pro Gly Val Glu Gly Val Thr His           
20                  25                  30                  35            

tac aag gcc ggc gac cct gtt att ctg tat gtc aac aaa gtg gga ccc        501
Tyr Lys Ala Gly Asp Pro Val Ile Leu Tyr Val Asn Lys Val Gly Pro           
                40                  45                  50                

tac cat aac cct cag gaa act tac cac tac tat cag ctt cca gtc tgc        549
Tyr His Asn Pro Gln Glu Thr Tyr His Tyr Tyr Gln Leu Pro Val Cys           
            55                  60                  65                    

tgc cct gag aag ata cgt cac aaa agc ctt agc ctg ggt gaa gtg ctg        597
Cys Pro Glu Lys Ile Arg His Lys Ser Leu Ser Leu Gly Glu Val Leu           
        70                  75                  80                        

gat ggg gac cga atg gct gag tct ttg tat gag atc cgc ttt cgg gaa        645
Asp Gly Asp Arg Met Ala Glu Ser Leu Tyr Glu Ile Arg Phe Arg Glu           
    85                  90                  95                            

aac gtg gag aag aga att ctg tgc cac atg cag ctc agt tct gca cag        693
Asn Val Glu Lys Arg Ile Leu Cys His Met Gln Leu Ser Ser Ala Gln           
100                 105                 110                 115           

gtg gag cag ctg cgc cag gcc att gaa gaa ctg tac tac ttt gaa ttt        741
Val Glu Gln Leu Arg Gln Ala Ile Glu Glu Leu Tyr Tyr Phe Glu Phe           
                120                 125                 130               

gtg gta gat gac ttg cca atc cgg ggc ttt gtg ggc tac atg gag gag        789
Val Val Asp Asp Leu Pro Ile Arg Gly Phe Val Gly Tyr Met Glu Glu           
            135                 140                 145                   

agt ggt ttc ctg cca cac agc cac aag ata gga ctc tgg acc cat ttg        837
Ser Gly Phe Leu Pro His Ser His Lys Ile Gly Leu Trp Thr His Leu           
        150                 155                 160                       

gac ttc cac cta gaa ttc cat gga gac cga att ata ttt gcc aat gtt        885
Asp Phe His Leu Glu Phe His Gly Asp Arg Ile Ile Phe Ala Asn Val           
    165                 170                 175                           

tca gtg cgg gac gtc aag ccc cac agc ttg gat ggg tta cga cct gac        933
Ser Val Arg Asp Val Lys Pro His Ser Leu Asp Gly Leu Arg Pro Asp           
180                 185                 190                 195           

gag ttc cta ggc ctt acc cac act tat agc gtg cgc tgg tct gag act        981
Glu Phe Leu Gly Leu Thr His Thr Tyr Ser Val Arg Trp Ser Glu Thr           
                200                 205                 210               

tca gtg gag cgt cgg agt gac agg cgc cgt ggt gac gat ggt ggt ttc       1029
Ser Val Glu Arg Arg Ser Asp Arg Arg Arg Gly Asp Asp Gly Gly Phe           
            215                 220                 225                   

ttt cct cga aca ctg gaa atc cat tgg ttg tcc atc atc aac tcc atg       1077
Phe Pro Arg Thr Leu Glu Ile His Trp Leu Ser Ile Ile Asn Ser Met           
        230                 235                 240                       

gtg ctt gtg ttt tta ctg gtg ggt ttt gtg gct gtc att cta atg cgt       1125
Val Leu Val Phe Leu Leu Val Gly Phe Val Ala Val Ile Leu Met Arg           
    245                 250                 255                           

gtg ctt cgg aat gac ctg gct cgg tac aac tta gat gag gag acc acc       1173
Val Leu Arg Asn Asp Leu Ala Arg Tyr Asn Leu Asp Glu Glu Thr Thr           
260                 265                 270                 275           

tct gca ggt tct ggt gat gac ttt gac cag ggt gac aat ggc tgg aaa       1221
Ser Ala Gly Ser Gly Asp Asp Phe Asp Gln Gly Asp Asn Gly Trp Lys           
                280                 285                 290               

att atc cat aca gat gtc ttc cgc ttc ccc cca tac cgt ggt ctg ctc       1269
Ile Ile His Thr Asp Val Phe Arg Phe Pro Pro Tyr Arg Gly Leu Leu           
            295                 300                 305                   

tgt gct gtg ctt ggc gtg ggt gcc cag ttc ctg gcc ctt ggc act ggc       1317
Cys Ala Val Leu Gly Val Gly Ala Gln Phe Leu Ala Leu Gly Thr Gly           
        310                 315                 320                       

att att gtc atg gca ctg ctg ggc atg ttc aat gtg cac cgt cat ggg       1365
Ile Ile Val Met Ala Leu Leu Gly Met Phe Asn Val His Arg His Gly           
    325                 330                 335                           

gcc att aac tca gca gcc atc ttg ttg tat gcc ctg acc tgc tgc atc       1413
Ala Ile Asn Ser Ala Ala Ile Leu Leu Tyr Ala Leu Thr Cys Cys Ile           
340                 345                 350                 355           

tct ggc tac gtg tcc agc cac ttc tac cgg cag att gga ggc gag cgt       1461
Ser Gly Tyr Val Ser Ser His Phe Tyr Arg Gln Ile Gly Gly Glu Arg           
                360                 365                 370               

tgg gtg tgg aac atc att ctc acc acc agt ctc ttc tct gtg cct ttc       1509
Trp Val Trp Asn Ile Ile Leu Thr Thr Ser Leu Phe Ser Val Pro Phe           
            375                 380                 385                   

ttc ctg acg tgg agt gtg gtg aac tca gtg cat tgg gcc aat ggt tcg       1557
Phe Leu Thr Trp Ser Val Val Asn Ser Val His Trp Ala Asn Gly Ser           
        390                 395                 400                       

aca cag gct ctg cca gcc aca acc atc ctg ctg ctt ctg acg gtt tgg       1605
Thr Gln Ala Leu Pro Ala Thr Thr Ile Leu Leu Leu Leu Thr Val Trp           
    405                 410                 415                           

ctg ctg gtg ggc ttt ccc ctc act gtc att gga ggc atc ttt ggg aag       1653
Leu Leu Val Gly Phe Pro Leu Thr Val Ile Gly Gly Ile Phe Gly Lys           
420                 425                 430                 435           

aac aac gcc agc ccc ttt gat gca ccc tgt cgc acc aag aac atc gcc       1701
Asn Asn Ala Ser Pro Phe Asp Ala Pro Cys Arg Thr Lys Asn Ile Ala           
                440                 445                 450               

cgg gag att cca ccc cag ccc tgg tac aag tct act gtc atc cac atg       1749
Arg Glu Ile Pro Pro Gln Pro Trp Tyr Lys Ser Thr Val Ile His Met           
            455                 460                 465                   

act gtt gga ggc ttc ctg cct ttc agt gcc atc tct gtg gag ctg tac       1797
Thr Val Gly Gly Phe Leu Pro Phe Ser Ala Ile Ser Val Glu Leu Tyr           
        470                 475                 480                       

tac atc ttt gcc aca gta tgg ggt cgg gag cag tac act ttg tac ggc       1845
Tyr Ile Phe Ala Thr Val Trp Gly Arg Glu Gln Tyr Thr Leu Tyr Gly           
    485                 490                 495                           

atc ctc ttc ttt gtc ttc gcc atc ctg ctg agt gtg ggg gct tgc atc       1893
Ile Leu Phe Phe Val Phe Ala Ile Leu Leu Ser Val Gly Ala Cys Ile           
500                 505                 510                 515           

tcc att gca ctc acc tac ttc cag ttg tct ggg gag gat tac cgc tgg       1941
Ser Ile Ala Leu Thr Tyr Phe Gln Leu Ser Gly Glu Asp Tyr Arg Trp           
                520                 525                 530               

tgg tgg cga tct gtg ctg agt gtt ggc tcc acc ggc ctc ttc atc ttc       1989
Trp Trp Arg Ser Val Leu Ser Val Gly Ser Thr Gly Leu Phe Ile Phe           
            535                 540                 545                   

ctc tac tca gtt ttc tat tat gcc cgg cgc tcc aac atg tct ggg gca       2037
Leu Tyr Ser Val Phe Tyr Tyr Ala Arg Arg Ser Asn Met Ser Gly Ala           
        550                 555                 560                       

gta cag aca gta gag ttc ttc ggc tac tcc tta ctc act ggt tat gtc       2085
Val Gln Thr Val Glu Phe Phe Gly Tyr Ser Leu Leu Thr Gly Tyr Val           
    565                 570                 575                           

ttc ttc ctc atg ctg ggc acc atc tcc ttt ttt tct tcc cta aag ttc       2133
Phe Phe Leu Met Leu Gly Thr Ile Ser Phe Phe Ser Ser Leu Lys Phe           
580                 585                 590                 595           

atc cgg tat atc tat gtt aac ctc aag atg gac tga gttctgtatg            2179
Ile Arg Tyr Ile Tyr Val Asn Leu Lys Met Asp                               
                600                 605                                   

gcagaactat tgctgttctc tccctttctt catgccctgt tgaactctcc taccagcttc     2239

tcttctgatt gactgaattg tgtgatggca ttgttgcctt cccttttgcc ctttgggcat     2299

tccttcccca gagagggcct ggaaattata aatctctatc acataaggat tatatatttg     2359

aactttttaa gttgccttta gttttggtcc tgatttttct ttttacaatt accaaaataa     2419

aatttattaa gaaaaaggaa aaaaaaaaaa                                      2449


<210>  2
<211>  606
<212>  PRT
<213>  Homo sapiens

<400>  2

Met Thr Val Val Gly Asn Pro Arg Ser Trp Ser Cys Gln Trp Leu Pro 
1               5                   10                  15      


Ile Leu Ile Leu Leu Leu Gly Thr Gly His Gly Pro Gly Val Glu Gly 
            20                  25                  30          


Val Thr His Tyr Lys Ala Gly Asp Pro Val Ile Leu Tyr Val Asn Lys 
        35                  40                  45              


Val Gly Pro Tyr His Asn Pro Gln Glu Thr Tyr His Tyr Tyr Gln Leu 
    50                  55                  60                  


Pro Val Cys Cys Pro Glu Lys Ile Arg His Lys Ser Leu Ser Leu Gly 
65                  70                  75                  80  


Glu Val Leu Asp Gly Asp Arg Met Ala Glu Ser Leu Tyr Glu Ile Arg 
                85                  90                  95      


Phe Arg Glu Asn Val Glu Lys Arg Ile Leu Cys His Met Gln Leu Ser 
            100                 105                 110         


Ser Ala Gln Val Glu Gln Leu Arg Gln Ala Ile Glu Glu Leu Tyr Tyr 
        115                 120                 125             


Phe Glu Phe Val Val Asp Asp Leu Pro Ile Arg Gly Phe Val Gly Tyr 
    130                 135                 140                 


Met Glu Glu Ser Gly Phe Leu Pro His Ser His Lys Ile Gly Leu Trp 
145                 150                 155                 160 


Thr His Leu Asp Phe His Leu Glu Phe His Gly Asp Arg Ile Ile Phe 
                165                 170                 175     


Ala Asn Val Ser Val Arg Asp Val Lys Pro His Ser Leu Asp Gly Leu 
            180                 185                 190         


Arg Pro Asp Glu Phe Leu Gly Leu Thr His Thr Tyr Ser Val Arg Trp 
        195                 200                 205             


Ser Glu Thr Ser Val Glu Arg Arg Ser Asp Arg Arg Arg Gly Asp Asp 
    210                 215                 220                 


Gly Gly Phe Phe Pro Arg Thr Leu Glu Ile His Trp Leu Ser Ile Ile 
225                 230                 235                 240 


Asn Ser Met Val Leu Val Phe Leu Leu Val Gly Phe Val Ala Val Ile 
                245                 250                 255     


Leu Met Arg Val Leu Arg Asn Asp Leu Ala Arg Tyr Asn Leu Asp Glu 
            260                 265                 270         


Glu Thr Thr Ser Ala Gly Ser Gly Asp Asp Phe Asp Gln Gly Asp Asn 
        275                 280                 285             


Gly Trp Lys Ile Ile His Thr Asp Val Phe Arg Phe Pro Pro Tyr Arg 
    290                 295                 300                 


Gly Leu Leu Cys Ala Val Leu Gly Val Gly Ala Gln Phe Leu Ala Leu 
305                 310                 315                 320 


Gly Thr Gly Ile Ile Val Met Ala Leu Leu Gly Met Phe Asn Val His 
                325                 330                 335     


Arg His Gly Ala Ile Asn Ser Ala Ala Ile Leu Leu Tyr Ala Leu Thr 
            340                 345                 350         


Cys Cys Ile Ser Gly Tyr Val Ser Ser His Phe Tyr Arg Gln Ile Gly 
        355                 360                 365             


Gly Glu Arg Trp Val Trp Asn Ile Ile Leu Thr Thr Ser Leu Phe Ser 
    370                 375                 380                 


Val Pro Phe Phe Leu Thr Trp Ser Val Val Asn Ser Val His Trp Ala 
385                 390                 395                 400 


Asn Gly Ser Thr Gln Ala Leu Pro Ala Thr Thr Ile Leu Leu Leu Leu 
                405                 410                 415     


Thr Val Trp Leu Leu Val Gly Phe Pro Leu Thr Val Ile Gly Gly Ile 
            420                 425                 430         


Phe Gly Lys Asn Asn Ala Ser Pro Phe Asp Ala Pro Cys Arg Thr Lys 
        435                 440                 445             


Asn Ile Ala Arg Glu Ile Pro Pro Gln Pro Trp Tyr Lys Ser Thr Val 
    450                 455                 460                 


Ile His Met Thr Val Gly Gly Phe Leu Pro Phe Ser Ala Ile Ser Val 
465                 470                 475                 480 


Glu Leu Tyr Tyr Ile Phe Ala Thr Val Trp Gly Arg Glu Gln Tyr Thr 
                485                 490                 495     


Leu Tyr Gly Ile Leu Phe Phe Val Phe Ala Ile Leu Leu Ser Val Gly 
            500                 505                 510         


Ala Cys Ile Ser Ile Ala Leu Thr Tyr Phe Gln Leu Ser Gly Glu Asp 
        515                 520                 525             


Tyr Arg Trp Trp Trp Arg Ser Val Leu Ser Val Gly Ser Thr Gly Leu 
    530                 535                 540                 


Phe Ile Phe Leu Tyr Ser Val Phe Tyr Tyr Ala Arg Arg Ser Asn Met 
545                 550                 555                 560 


Ser Gly Ala Val Gln Thr Val Glu Phe Phe Gly Tyr Ser Leu Leu Thr 
                565                 570                 575     


Gly Tyr Val Phe Phe Leu Met Leu Gly Thr Ile Ser Phe Phe Ser Ser 
            580                 585                 590         


Leu Lys Phe Ile Arg Tyr Ile Tyr Val Asn Leu Lys Met Asp 
        595                 600                 605     


<210>  3
<211>  2124
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (349)..(1818)

<400>  3
ggccgcgctg ccgatcgccg ggaggacccc cgcctcgccg aagacgggcg gggcaagccg       60

agcctcacgg ggtccccgga gctgggccgg gcctccagat ggagaaggcg caacggggag      120

ttcttgagta agccagagcg gtgtccagcg cggtgtagcc gcagccgccg ctgtcaggcg      180

cagcaacggg caaccccgta gaagtcggtc ggcaggtcct ctccaacccg ccgctaccgc      240

gccgctgtgg gagagacccc agcaggagcc caaaggcagc tacgggggcg cgaaggccgc      300

tggcgccgcc tcggccagcc cttcccgcgc ggttccactg ccttaagg atg aca gtc       357
                                                     Met Thr Val          
                                                     1                    

gta ggg aac cct cga agt tgg agc tgc cag tgg ttg cca atc ctg ata        405
Val Gly Asn Pro Arg Ser Trp Ser Cys Gln Trp Leu Pro Ile Leu Ile           
    5                   10                  15                            

ctg ttg ctg ggc aca ggc cat ggg cca ggg gtg gaa ggc gtg aca cac        453
Leu Leu Leu Gly Thr Gly His Gly Pro Gly Val Glu Gly Val Thr His           
20                  25                  30                  35            

tac aag gcc ggc gac cct gtt att ctg tat gtc aac aaa gtg gga ccc        501
Tyr Lys Ala Gly Asp Pro Val Ile Leu Tyr Val Asn Lys Val Gly Pro           
                40                  45                  50                

tac cat aac cct cag gaa act tac cac tac tat cag ctt cca gtc tgc        549
Tyr His Asn Pro Gln Glu Thr Tyr His Tyr Tyr Gln Leu Pro Val Cys           
            55                  60                  65                    

tgc cct gag aag ata cgt cac aaa agc ctt agc ctg ggt gaa gtg ctg        597
Cys Pro Glu Lys Ile Arg His Lys Ser Leu Ser Leu Gly Glu Val Leu           
        70                  75                  80                        

gat ggg gac cga atg gct gag tct ttg tat gag atc cgc ttt cgg gaa        645
Asp Gly Asp Arg Met Ala Glu Ser Leu Tyr Glu Ile Arg Phe Arg Glu           
    85                  90                  95                            

aac gtg gag aag aga att ctg tgc cac atg cag ctc agt tct gca cag        693
Asn Val Glu Lys Arg Ile Leu Cys His Met Gln Leu Ser Ser Ala Gln           
100                 105                 110                 115           

gtg gag cag ctg cgc cag gcc att gaa gaa ctg tac tac ttt gaa ttt        741
Val Glu Gln Leu Arg Gln Ala Ile Glu Glu Leu Tyr Tyr Phe Glu Phe           
                120                 125                 130               

gtg gta gat gac ttg cca atc cgg ggc ttt gtg ggc tac atg gag gag        789
Val Val Asp Asp Leu Pro Ile Arg Gly Phe Val Gly Tyr Met Glu Glu           
            135                 140                 145                   

agt ggt ttc ctg cca cac agc cac aag ata gga ctc tgg acc cat ttg        837
Ser Gly Phe Leu Pro His Ser His Lys Ile Gly Leu Trp Thr His Leu           
        150                 155                 160                       

gac ttc cac cta gaa ttc cat gga gac cga att ata ttt gcc aat gtt        885
Asp Phe His Leu Glu Phe His Gly Asp Arg Ile Ile Phe Ala Asn Val           
    165                 170                 175                           

tca gtg cgg gac gtc aag ccc cac agc ttg gat ggg tta cga cct gac        933
Ser Val Arg Asp Val Lys Pro His Ser Leu Asp Gly Leu Arg Pro Asp           
180                 185                 190                 195           

gag ttc cta ggc ctt acc cac act tat agc gtg cgc tgg tct gag act        981
Glu Phe Leu Gly Leu Thr His Thr Tyr Ser Val Arg Trp Ser Glu Thr           
                200                 205                 210               

tca gtg gag cgt cgg agt gac agg cgc cgt ggt gac gat ggt ggt ttc       1029
Ser Val Glu Arg Arg Ser Asp Arg Arg Arg Gly Asp Asp Gly Gly Phe           
            215                 220                 225                   

ttt cct cga aca ctg gaa atc cat tgg ttg tcc atc atc aac tcc atg       1077
Phe Pro Arg Thr Leu Glu Ile His Trp Leu Ser Ile Ile Asn Ser Met           
        230                 235                 240                       

gtg ctt gtg ttt tta ctg gtg ggt ttt gtg gct gtc att cta atg cgt       1125
Val Leu Val Phe Leu Leu Val Gly Phe Val Ala Val Ile Leu Met Arg           
    245                 250                 255                           

gtg ctt cgg aat gac ctg gct cgg tac aac tta gat gag gag acc acc       1173
Val Leu Arg Asn Asp Leu Ala Arg Tyr Asn Leu Asp Glu Glu Thr Thr           
260                 265                 270                 275           

tct gca ggt tct ggt gat gac ttt gac cag ggt gac aat ggc tgg aaa       1221
Ser Ala Gly Ser Gly Asp Asp Phe Asp Gln Gly Asp Asn Gly Trp Lys           
                280                 285                 290               

att atc cat aca gat gtc ttc cgc ttc ccc cca tac cgt ggt ctg ctc       1269
Ile Ile His Thr Asp Val Phe Arg Phe Pro Pro Tyr Arg Gly Leu Leu           
            295                 300                 305                   

tgt gct gtg ctt ggc gtg ggt gcc cag ttc ctg gcc ctt ggc act ggc       1317
Cys Ala Val Leu Gly Val Gly Ala Gln Phe Leu Ala Leu Gly Thr Gly           
        310                 315                 320                       

att att gtc atg gca ctg ctg ggc atg ttc aat gtg cac cgt cat ggg       1365
Ile Ile Val Met Ala Leu Leu Gly Met Phe Asn Val His Arg His Gly           
    325                 330                 335                           

gcc att aac tca gca gcc atc ttg ttg tat gcc ctg acc tgc tgc atc       1413
Ala Ile Asn Ser Ala Ala Ile Leu Leu Tyr Ala Leu Thr Cys Cys Ile           
340                 345                 350                 355           

tct ggc tac gtg tcc agc cac ttc tac cgg cag att gga ggc gag cgt       1461
Ser Gly Tyr Val Ser Ser His Phe Tyr Arg Gln Ile Gly Gly Glu Arg           
                360                 365                 370               

tgg gtg tgg aac atc att ctc acc acc agt ctc ttc tct gtg cct ttc       1509
Trp Val Trp Asn Ile Ile Leu Thr Thr Ser Leu Phe Ser Val Pro Phe           
            375                 380                 385                   

ttc ctg acg tgg agt gtg gtg aac tca gtg cat tgg gcc aat ggt tcg       1557
Phe Leu Thr Trp Ser Val Val Asn Ser Val His Trp Ala Asn Gly Ser           
        390                 395                 400                       

aca cag gct ctg cca gcc aca acc atc ctg ctg ctt ctg acg gtt tgg       1605
Thr Gln Ala Leu Pro Ala Thr Thr Ile Leu Leu Leu Leu Thr Val Trp           
    405                 410                 415                           

ctg ctg gtg ggc ttt ccc ctc act gtc att gga ggc atc ttt ggg aag       1653
Leu Leu Val Gly Phe Pro Leu Thr Val Ile Gly Gly Ile Phe Gly Lys           
420                 425                 430                 435           

aac aac gcc agc ccc ttt gat gca ccc tgt cgc acc aag aac atc gcc       1701
Asn Asn Ala Ser Pro Phe Asp Ala Pro Cys Arg Thr Lys Asn Ile Ala           
                440                 445                 450               

cgg gag att cca ccc cag ccc tgg tac aag tct act gtc atc cac atg       1749
Arg Glu Ile Pro Pro Gln Pro Trp Tyr Lys Ser Thr Val Ile His Met           
            455                 460                 465                   

act gtt gga ggc ttc ctg cct ttc agg tat cct ccc ttt att cca tgg       1797
Thr Val Gly Gly Phe Leu Pro Phe Arg Tyr Pro Pro Phe Ile Pro Trp           
        470                 475                 480                       

cta tta ctg tca ggt tcc tga cctcaatttt tcctgtccct actcatccag          1848
Leu Leu Leu Ser Gly Ser                                                   
    485                                                                   

taccctaacc caacccgttg atccctggtt cagtggtacc attcagagat cattaaatgg     1908

ttcctcctat ccccaagcag gactgagctt gaatgatatg agagtgtctc acttataaag     1968

ctctccggag acatttcccc cttcaccttc ctggtttctg actttaatgc ctatggacat     2028

catgtggggt ttaaagccca tttgatgacc catttacttt gttgaatacc tctttgtgcc     2088

aggcaaagaa taaagtggaa taaaatggaa aaaaaa                               2124


<210>  4
<211>  489
<212>  PRT
<213>  Homo sapiens

<400>  4

Met Thr Val Val Gly Asn Pro Arg Ser Trp Ser Cys Gln Trp Leu Pro 
1               5                   10                  15      


Ile Leu Ile Leu Leu Leu Gly Thr Gly His Gly Pro Gly Val Glu Gly 
            20                  25                  30          


Val Thr His Tyr Lys Ala Gly Asp Pro Val Ile Leu Tyr Val Asn Lys 
        35                  40                  45              


Val Gly Pro Tyr His Asn Pro Gln Glu Thr Tyr His Tyr Tyr Gln Leu 
    50                  55                  60                  


Pro Val Cys Cys Pro Glu Lys Ile Arg His Lys Ser Leu Ser Leu Gly 
65                  70                  75                  80  


Glu Val Leu Asp Gly Asp Arg Met Ala Glu Ser Leu Tyr Glu Ile Arg 
                85                  90                  95      


Phe Arg Glu Asn Val Glu Lys Arg Ile Leu Cys His Met Gln Leu Ser 
            100                 105                 110         


Ser Ala Gln Val Glu Gln Leu Arg Gln Ala Ile Glu Glu Leu Tyr Tyr 
        115                 120                 125             


Phe Glu Phe Val Val Asp Asp Leu Pro Ile Arg Gly Phe Val Gly Tyr 
    130                 135                 140                 


Met Glu Glu Ser Gly Phe Leu Pro His Ser His Lys Ile Gly Leu Trp 
145                 150                 155                 160 


Thr His Leu Asp Phe His Leu Glu Phe His Gly Asp Arg Ile Ile Phe 
                165                 170                 175     


Ala Asn Val Ser Val Arg Asp Val Lys Pro His Ser Leu Asp Gly Leu 
            180                 185                 190         


Arg Pro Asp Glu Phe Leu Gly Leu Thr His Thr Tyr Ser Val Arg Trp 
        195                 200                 205             


Ser Glu Thr Ser Val Glu Arg Arg Ser Asp Arg Arg Arg Gly Asp Asp 
    210                 215                 220                 


Gly Gly Phe Phe Pro Arg Thr Leu Glu Ile His Trp Leu Ser Ile Ile 
225                 230                 235                 240 


Asn Ser Met Val Leu Val Phe Leu Leu Val Gly Phe Val Ala Val Ile 
                245                 250                 255     


Leu Met Arg Val Leu Arg Asn Asp Leu Ala Arg Tyr Asn Leu Asp Glu 
            260                 265                 270         


Glu Thr Thr Ser Ala Gly Ser Gly Asp Asp Phe Asp Gln Gly Asp Asn 
        275                 280                 285             


Gly Trp Lys Ile Ile His Thr Asp Val Phe Arg Phe Pro Pro Tyr Arg 
    290                 295                 300                 


Gly Leu Leu Cys Ala Val Leu Gly Val Gly Ala Gln Phe Leu Ala Leu 
305                 310                 315                 320 


Gly Thr Gly Ile Ile Val Met Ala Leu Leu Gly Met Phe Asn Val His 
                325                 330                 335     


Arg His Gly Ala Ile Asn Ser Ala Ala Ile Leu Leu Tyr Ala Leu Thr 
            340                 345                 350         


Cys Cys Ile Ser Gly Tyr Val Ser Ser His Phe Tyr Arg Gln Ile Gly 
        355                 360                 365             


Gly Glu Arg Trp Val Trp Asn Ile Ile Leu Thr Thr Ser Leu Phe Ser 
    370                 375                 380                 


Val Pro Phe Phe Leu Thr Trp Ser Val Val Asn Ser Val His Trp Ala 
385                 390                 395                 400 


Asn Gly Ser Thr Gln Ala Leu Pro Ala Thr Thr Ile Leu Leu Leu Leu 
                405                 410                 415     


Thr Val Trp Leu Leu Val Gly Phe Pro Leu Thr Val Ile Gly Gly Ile 
            420                 425                 430         


Phe Gly Lys Asn Asn Ala Ser Pro Phe Asp Ala Pro Cys Arg Thr Lys 
        435                 440                 445             


Asn Ile Ala Arg Glu Ile Pro Pro Gln Pro Trp Tyr Lys Ser Thr Val 
    450                 455                 460                 


Ile His Met Thr Val Gly Gly Phe Leu Pro Phe Arg Tyr Pro Pro Phe 
465                 470                 475                 480 


Ile Pro Trp Leu Leu Leu Ser Gly Ser 
                485                 


<210>  5
<211>  2391
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (134)..(2125)

<400>  5
cgcaaccgga actagccttc tgggggccgg cttggtttat ctctggcggc cttgtagtcg       60

tctccgagac tccccacccc tccttccctc ttgaccccct aggtttgatt gccctttccc      120

cgaaacaact atc atg agc gcg agg ctg ccg gtg ttg tct cca cct cgg         169
               Met Ser Ala Arg Leu Pro Val Leu Ser Pro Pro Arg            
               1               5                   10                     

tgg ccg cgg ctg ttg ctg ctg tcg ctg ctc ctg ctg ggg gcg gtt cct        217
Trp Pro Arg Leu Leu Leu Leu Ser Leu Leu Leu Leu Gly Ala Val Pro           
        15                  20                  25                        

ggc ccg cgc cgg agc ggc gct ttc tac ctg ccc ggc ctg gcg ccc gtc        265
Gly Pro Arg Arg Ser Gly Ala Phe Tyr Leu Pro Gly Leu Ala Pro Val           
    30                  35                  40                            

aac ttc tgc gac gaa gaa aaa aag agc gac gag tgc aag gcc gaa ata        313
Asn Phe Cys Asp Glu Glu Lys Lys Ser Asp Glu Cys Lys Ala Glu Ile           
45                  50                  55                  60            

gaa cta ttt gtg aac aga ctt gat tca gtg gaa tca gtt ctt cct tat        361
Glu Leu Phe Val Asn Arg Leu Asp Ser Val Glu Ser Val Leu Pro Tyr           
                65                  70                  75                

gaa tac aca gcg ttt gat ttt tgc caa gca tca gaa gga aag cgc cca        409
Glu Tyr Thr Ala Phe Asp Phe Cys Gln Ala Ser Glu Gly Lys Arg Pro           
            80                  85                  90                    

tct gaa aat ctt ggt cag gta cta ttc ggg gaa aga att gaa cct tca        457
Ser Glu Asn Leu Gly Gln Val Leu Phe Gly Glu Arg Ile Glu Pro Ser           
        95                  100                 105                       

cca tat aag ttt acg ttt aat aag aag gag acc tgt aag ctt gtt tgt        505
Pro Tyr Lys Phe Thr Phe Asn Lys Lys Glu Thr Cys Lys Leu Val Cys           
    110                 115                 120                           

aca aaa aca tac cat aca gag aaa gct gaa gac aaa caa aag tta gaa        553
Thr Lys Thr Tyr His Thr Glu Lys Ala Glu Asp Lys Gln Lys Leu Glu           
125                 130                 135                 140           

ttc ttg aaa aaa agc atg tta ttg aat tat caa cat cac tgg att gtg        601
Phe Leu Lys Lys Ser Met Leu Leu Asn Tyr Gln His His Trp Ile Val           
                145                 150                 155               

gat aat atg cct gta acg tgg tgt tac gat gtt gaa gat ggt cag agg        649
Asp Asn Met Pro Val Thr Trp Cys Tyr Asp Val Glu Asp Gly Gln Arg           
            160                 165                 170                   

ttc tgt aat cct gga ttt cct att ggc tgt tac att aca gat aaa ggc        697
Phe Cys Asn Pro Gly Phe Pro Ile Gly Cys Tyr Ile Thr Asp Lys Gly           
        175                 180                 185                       

cat gca aaa gat gcc tgt gtt att agt tca gat ttc cat gaa aga gat        745
His Ala Lys Asp Ala Cys Val Ile Ser Ser Asp Phe His Glu Arg Asp           
    190                 195                 200                           

aca ttt tac atc ttc aac cat gtt gac atc aaa ata tac tat cat gtt        793
Thr Phe Tyr Ile Phe Asn His Val Asp Ile Lys Ile Tyr Tyr His Val           
205                 210                 215                 220           

gtt gaa act ggg tcc atg gga gca aga tta gtg gct gct aaa ctt gaa        841
Val Glu Thr Gly Ser Met Gly Ala Arg Leu Val Ala Ala Lys Leu Glu           
                225                 230                 235               

ccg aaa agc ttc aaa cat acc cat ata gat aaa cca gac tgc tca ggg        889
Pro Lys Ser Phe Lys His Thr His Ile Asp Lys Pro Asp Cys Ser Gly           
            240                 245                 250                   

ccc ccc atg gac ata agt aac aag gct tct ggg gag ata aaa att gcc        937
Pro Pro Met Asp Ile Ser Asn Lys Ala Ser Gly Glu Ile Lys Ile Ala           
        255                 260                 265                       

tat act tac tct gtt agc ttc gag gaa gat gat aag atc aga tgg gcg        985
Tyr Thr Tyr Ser Val Ser Phe Glu Glu Asp Asp Lys Ile Arg Trp Ala           
    270                 275                 280                           

tct aga tgg gac tat att ctg gag tct atg cct cat acc cac att cag       1033
Ser Arg Trp Asp Tyr Ile Leu Glu Ser Met Pro His Thr His Ile Gln           
285                 290                 295                 300           

tgg ttt agc att atg aat tcc ctg gtc att gtt ctc ttc tta tct gga       1081
Trp Phe Ser Ile Met Asn Ser Leu Val Ile Val Leu Phe Leu Ser Gly           
                305                 310                 315               

atg gta gct atg att atg tta cgg aca ctg cac aaa gat att gct aga       1129
Met Val Ala Met Ile Met Leu Arg Thr Leu His Lys Asp Ile Ala Arg           
            320                 325                 330                   

tat aat cag atg gac tct acg gaa gat gcc cag gaa gaa ttt ggc tgg       1177
Tyr Asn Gln Met Asp Ser Thr Glu Asp Ala Gln Glu Glu Phe Gly Trp           
        335                 340                 345                       

aaa ctt gtt cat ggt gat ata ttc cgt cct cca aga aaa ggg atg ctg       1225
Lys Leu Val His Gly Asp Ile Phe Arg Pro Pro Arg Lys Gly Met Leu           
    350                 355                 360                           

cta tca gtc ttt cta gga tcc ggg aca cag att tta att atg acc ttt       1273
Leu Ser Val Phe Leu Gly Ser Gly Thr Gln Ile Leu Ile Met Thr Phe           
365                 370                 375                 380           

gtg act cta ttt ttc gct tgc ctg gga ttt ttg tca cct gcc aac cga       1321
Val Thr Leu Phe Phe Ala Cys Leu Gly Phe Leu Ser Pro Ala Asn Arg           
                385                 390                 395               

gga gcg ctg atg acg tgt gct gtg gtc ctg tgg gtg ctg ctg ggc acc       1369
Gly Ala Leu Met Thr Cys Ala Val Val Leu Trp Val Leu Leu Gly Thr           
            400                 405                 410                   

cct gca ggc tat gtt gct gcc aga ttc tat aag tcc ttt gga ggt gag       1417
Pro Ala Gly Tyr Val Ala Ala Arg Phe Tyr Lys Ser Phe Gly Gly Glu           
        415                 420                 425                       

aag tgg aaa aca aat gtt tta tta aca tca ttt ctt tgt cct ggg att       1465
Lys Trp Lys Thr Asn Val Leu Leu Thr Ser Phe Leu Cys Pro Gly Ile           
    430                 435                 440                           

gta ttt gct gac ttc ttt ata atg aat ctg atc ctc tgg gga gaa gga       1513
Val Phe Ala Asp Phe Phe Ile Met Asn Leu Ile Leu Trp Gly Glu Gly           
445                 450                 455                 460           

tct tca gca gct att cct ttt ggg aca ctg gtt gcc ata ttg gcc ctt       1561
Ser Ser Ala Ala Ile Pro Phe Gly Thr Leu Val Ala Ile Leu Ala Leu           
                465                 470                 475               

tgg ttc tgc ata tct gtg cct ctg acg ttt att ggt gca tac ttt ggt       1609
Trp Phe Cys Ile Ser Val Pro Leu Thr Phe Ile Gly Ala Tyr Phe Gly           
            480                 485                 490                   

ttt aag aag aat gcc att gaa cac cca gtt cga acc aat cag att cca       1657
Phe Lys Lys Asn Ala Ile Glu His Pro Val Arg Thr Asn Gln Ile Pro           
        495                 500                 505                       

cgt cag att cct gaa cag tcg ttc tac acg aag ccc ttg cct ggt att       1705
Arg Gln Ile Pro Glu Gln Ser Phe Tyr Thr Lys Pro Leu Pro Gly Ile           
    510                 515                 520                           

atc atg gga ggg att ttg ccc ttt ggc tgc atc ttt ata caa ctt ttc       1753
Ile Met Gly Gly Ile Leu Pro Phe Gly Cys Ile Phe Ile Gln Leu Phe           
525                 530                 535                 540           

ttc att ctg aat agt att tgg tca cac cag atg tat tac atg ttt ggc       1801
Phe Ile Leu Asn Ser Ile Trp Ser His Gln Met Tyr Tyr Met Phe Gly           
                545                 550                 555               

ttc cta ttt ctg gtg ttt atc att ttg gtt att acc tgt tct gaa gca       1849
Phe Leu Phe Leu Val Phe Ile Ile Leu Val Ile Thr Cys Ser Glu Ala           
            560                 565                 570                   

act ata ctt ctt tgc tat ttc cac cta tgt gca gag gat tat cat tgg       1897
Thr Ile Leu Leu Cys Tyr Phe His Leu Cys Ala Glu Asp Tyr His Trp           
        575                 580                 585                       

caa tgg cgt tca ttc ctt acg agt ggc ttt act gca gtt tat ttc tta       1945
Gln Trp Arg Ser Phe Leu Thr Ser Gly Phe Thr Ala Val Tyr Phe Leu           
    590                 595                 600                           

atc tat gca gta cac tac ttc ttt tca aaa ctg cag atc acg gga aca       1993
Ile Tyr Ala Val His Tyr Phe Phe Ser Lys Leu Gln Ile Thr Gly Thr           
605                 610                 615                 620           

gca agc aca att ctg tac ttt ggt tat acc atg ata atg gtt ttg atc       2041
Ala Ser Thr Ile Leu Tyr Phe Gly Tyr Thr Met Ile Met Val Leu Ile           
                625                 630                 635               

ttc ttt ctt ttt aca gga aca att ggc ttc ttt gca tgc ttt tgg ttt       2089
Phe Phe Leu Phe Thr Gly Thr Ile Gly Phe Phe Ala Cys Phe Trp Phe           
            640                 645                 650                   

gtt acc aaa ata tac agt gtg gtg aag gtt gac tga agaagtccag            2135
Val Thr Lys Ile Tyr Ser Val Val Lys Val Asp                               
        655                 660                                           

tgtgtccagt taaaacagaa ataaattaaa ctcttcatca acaaagacct gtttttgtga     2195

ctgccttgag ttttatcaga attattggcc tagtaatcct tcagaaacac cgtaattcta     2255

aataaacctc ttcccataca cctttccccc ataagatctg tcttcaacac tataaagcat     2315

ttgtattgtg atttgattaa gtatatattt ggttgttctc aatgaagagc aaatttaaat     2375

attatgtgca tttgaa                                                     2391


<210>  6
<211>  663
<212>  PRT
<213>  Homo sapiens

<400>  6

Met Ser Ala Arg Leu Pro Val Leu Ser Pro Pro Arg Trp Pro Arg Leu 
1               5                   10                  15      


Leu Leu Leu Ser Leu Leu Leu Leu Gly Ala Val Pro Gly Pro Arg Arg 
            20                  25                  30          


Ser Gly Ala Phe Tyr Leu Pro Gly Leu Ala Pro Val Asn Phe Cys Asp 
        35                  40                  45              


Glu Glu Lys Lys Ser Asp Glu Cys Lys Ala Glu Ile Glu Leu Phe Val 
    50                  55                  60                  


Asn Arg Leu Asp Ser Val Glu Ser Val Leu Pro Tyr Glu Tyr Thr Ala 
65                  70                  75                  80  


Phe Asp Phe Cys Gln Ala Ser Glu Gly Lys Arg Pro Ser Glu Asn Leu 
                85                  90                  95      


Gly Gln Val Leu Phe Gly Glu Arg Ile Glu Pro Ser Pro Tyr Lys Phe 
            100                 105                 110         


Thr Phe Asn Lys Lys Glu Thr Cys Lys Leu Val Cys Thr Lys Thr Tyr 
        115                 120                 125             


His Thr Glu Lys Ala Glu Asp Lys Gln Lys Leu Glu Phe Leu Lys Lys 
    130                 135                 140                 


Ser Met Leu Leu Asn Tyr Gln His His Trp Ile Val Asp Asn Met Pro 
145                 150                 155                 160 


Val Thr Trp Cys Tyr Asp Val Glu Asp Gly Gln Arg Phe Cys Asn Pro 
                165                 170                 175     


Gly Phe Pro Ile Gly Cys Tyr Ile Thr Asp Lys Gly His Ala Lys Asp 
            180                 185                 190         


Ala Cys Val Ile Ser Ser Asp Phe His Glu Arg Asp Thr Phe Tyr Ile 
        195                 200                 205             


Phe Asn His Val Asp Ile Lys Ile Tyr Tyr His Val Val Glu Thr Gly 
    210                 215                 220                 


Ser Met Gly Ala Arg Leu Val Ala Ala Lys Leu Glu Pro Lys Ser Phe 
225                 230                 235                 240 


Lys His Thr His Ile Asp Lys Pro Asp Cys Ser Gly Pro Pro Met Asp 
                245                 250                 255     


Ile Ser Asn Lys Ala Ser Gly Glu Ile Lys Ile Ala Tyr Thr Tyr Ser 
            260                 265                 270         


Val Ser Phe Glu Glu Asp Asp Lys Ile Arg Trp Ala Ser Arg Trp Asp 
        275                 280                 285             


Tyr Ile Leu Glu Ser Met Pro His Thr His Ile Gln Trp Phe Ser Ile 
    290                 295                 300                 


Met Asn Ser Leu Val Ile Val Leu Phe Leu Ser Gly Met Val Ala Met 
305                 310                 315                 320 


Ile Met Leu Arg Thr Leu His Lys Asp Ile Ala Arg Tyr Asn Gln Met 
                325                 330                 335     


Asp Ser Thr Glu Asp Ala Gln Glu Glu Phe Gly Trp Lys Leu Val His 
            340                 345                 350         


Gly Asp Ile Phe Arg Pro Pro Arg Lys Gly Met Leu Leu Ser Val Phe 
        355                 360                 365             


Leu Gly Ser Gly Thr Gln Ile Leu Ile Met Thr Phe Val Thr Leu Phe 
    370                 375                 380                 


Phe Ala Cys Leu Gly Phe Leu Ser Pro Ala Asn Arg Gly Ala Leu Met 
385                 390                 395                 400 


Thr Cys Ala Val Val Leu Trp Val Leu Leu Gly Thr Pro Ala Gly Tyr 
                405                 410                 415     


Val Ala Ala Arg Phe Tyr Lys Ser Phe Gly Gly Glu Lys Trp Lys Thr 
            420                 425                 430         


Asn Val Leu Leu Thr Ser Phe Leu Cys Pro Gly Ile Val Phe Ala Asp 
        435                 440                 445             


Phe Phe Ile Met Asn Leu Ile Leu Trp Gly Glu Gly Ser Ser Ala Ala 
    450                 455                 460                 


Ile Pro Phe Gly Thr Leu Val Ala Ile Leu Ala Leu Trp Phe Cys Ile 
465                 470                 475                 480 


Ser Val Pro Leu Thr Phe Ile Gly Ala Tyr Phe Gly Phe Lys Lys Asn 
                485                 490                 495     


Ala Ile Glu His Pro Val Arg Thr Asn Gln Ile Pro Arg Gln Ile Pro 
            500                 505                 510         


Glu Gln Ser Phe Tyr Thr Lys Pro Leu Pro Gly Ile Ile Met Gly Gly 
        515                 520                 525             


Ile Leu Pro Phe Gly Cys Ile Phe Ile Gln Leu Phe Phe Ile Leu Asn 
    530                 535                 540                 


Ser Ile Trp Ser His Gln Met Tyr Tyr Met Phe Gly Phe Leu Phe Leu 
545                 550                 555                 560 


Val Phe Ile Ile Leu Val Ile Thr Cys Ser Glu Ala Thr Ile Leu Leu 
                565                 570                 575     


Cys Tyr Phe His Leu Cys Ala Glu Asp Tyr His Trp Gln Trp Arg Ser 
            580                 585                 590         


Phe Leu Thr Ser Gly Phe Thr Ala Val Tyr Phe Leu Ile Tyr Ala Val 
        595                 600                 605             


His Tyr Phe Phe Ser Lys Leu Gln Ile Thr Gly Thr Ala Ser Thr Ile 
    610                 615                 620                 


Leu Tyr Phe Gly Tyr Thr Met Ile Met Val Leu Ile Phe Phe Leu Phe 
625                 630                 635                 640 


Thr Gly Thr Ile Gly Phe Phe Ala Cys Phe Trp Phe Val Thr Lys Ile 
                645                 650                 655     


Tyr Ser Val Val Lys Val Asp 
            660             


<210>  7
<211>  6140
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (218)..(1987)

<400>  7
gaggaagagg ctgaggaggc gcggggggcg ggggaggctc aggagcgggc ggtgacggcg       60

acggcggcgg cagaggaggc agcggctggg ccgggccccg tgcgtctgtc cgcgccccgt      120

ggatgcgaat cggccgcggc ggaggcggcg gcggcggagg aggcggcggc gggaggagga      180

gtcggtgagc cggctccggg ccggaggggc gcggagg atg agg ccg ctg cct ggc       235
                                         Met Arg Pro Leu Pro Gly          
                                         1               5                

gct ctt ggc gtg gcg gcg gcc gcc gcg ctg tgg ctg ctg ctg ctg ctg        283
Ala Leu Gly Val Ala Ala Ala Ala Ala Leu Trp Leu Leu Leu Leu Leu           
            10                  15                  20                    

ctg ccc cgg acc cgg gcg gac gag cac gaa cac acg tat caa gat aaa        331
Leu Pro Arg Thr Arg Ala Asp Glu His Glu His Thr Tyr Gln Asp Lys           
        25                  30                  35                        

gag gaa gtt gtc tta tgg atg aat act gtt ggg ccc tac cat aat cgt        379
Glu Glu Val Val Leu Trp Met Asn Thr Val Gly Pro Tyr His Asn Arg           
    40                  45                  50                            

caa gaa aca tat aag tac ttt tca ctt cca ttc tgt gtg ggg tca aaa        427
Gln Glu Thr Tyr Lys Tyr Phe Ser Leu Pro Phe Cys Val Gly Ser Lys           
55                  60                  65                  70            

aaa agt atc agt cat tac cat gaa act ctg gga gaa gca ctt caa ggg        475
Lys Ser Ile Ser His Tyr His Glu Thr Leu Gly Glu Ala Leu Gln Gly           
                75                  80                  85                

gtt gaa ttg gaa ttt agt ggt ctg gat att aaa ttt aaa gat gat gtg        523
Val Glu Leu Glu Phe Ser Gly Leu Asp Ile Lys Phe Lys Asp Asp Val           
            90                  95                  100                   

atg cca gcc act tac tgt gaa att gat tta gat aaa gaa aag aga gat        571
Met Pro Ala Thr Tyr Cys Glu Ile Asp Leu Asp Lys Glu Lys Arg Asp           
        105                 110                 115                       

gca ttt gta tat gcc ata aaa aat cat tac tgg tac cag atg tac ata        619
Ala Phe Val Tyr Ala Ile Lys Asn His Tyr Trp Tyr Gln Met Tyr Ile           
    120                 125                 130                           

gat gat tta cca ata tgg ggt att gtt ggt gag gct gat gaa aat gga        667
Asp Asp Leu Pro Ile Trp Gly Ile Val Gly Glu Ala Asp Glu Asn Gly           
135                 140                 145                 150           

gaa gat tac tat ctt tgg acc tat aaa aaa ctt gaa ata ggt ttt aat        715
Glu Asp Tyr Tyr Leu Trp Thr Tyr Lys Lys Leu Glu Ile Gly Phe Asn           
                155                 160                 165               

gga aat cga att gtt gat gtt aat cta act agt gaa gga aag gtg aaa        763
Gly Asn Arg Ile Val Asp Val Asn Leu Thr Ser Glu Gly Lys Val Lys           
            170                 175                 180                   

ctg gtt cca aat act aaa atc cag atg tca tat tca gta aaa tgg aaa        811
Leu Val Pro Asn Thr Lys Ile Gln Met Ser Tyr Ser Val Lys Trp Lys           
        185                 190                 195                       

aag tca gat gtg aaa ttt gaa gat cga ttt gac aaa tat ctt gat ccg        859
Lys Ser Asp Val Lys Phe Glu Asp Arg Phe Asp Lys Tyr Leu Asp Pro           
    200                 205                 210                           

tcc ttt ttt caa cat cgg att cat tgg ttt tca att ttc aac tcc ttc        907
Ser Phe Phe Gln His Arg Ile His Trp Phe Ser Ile Phe Asn Ser Phe           
215                 220                 225                 230           

atg atg gtg atc ttc ttg gtg ggc tta gtt tca atg att tta atg aga        955
Met Met Val Ile Phe Leu Val Gly Leu Val Ser Met Ile Leu Met Arg           
                235                 240                 245               

aca tta aga aaa gat tat gct cgg tac agt aaa gag gaa gaa atg gat       1003
Thr Leu Arg Lys Asp Tyr Ala Arg Tyr Ser Lys Glu Glu Glu Met Asp           
            250                 255                 260                   

gat atg gat aga gac cta gga gat gaa tat gga tgg aaa cag gtg cat       1051
Asp Met Asp Arg Asp Leu Gly Asp Glu Tyr Gly Trp Lys Gln Val His           
        265                 270                 275                       

gga gat gta ttt aga cca tca agt cac cca ctg ata ttt tcc tct ctg       1099
Gly Asp Val Phe Arg Pro Ser Ser His Pro Leu Ile Phe Ser Ser Leu           
    280                 285                 290                           

att ggt tct gga tgt cag ata ttt gct gtg tct ctc atc gtt att att       1147
Ile Gly Ser Gly Cys Gln Ile Phe Ala Val Ser Leu Ile Val Ile Ile           
295                 300                 305                 310           

gtt gca atg ata gaa gat tta tat act gag agg gga tca atg ctc agt       1195
Val Ala Met Ile Glu Asp Leu Tyr Thr Glu Arg Gly Ser Met Leu Ser           
                315                 320                 325               

aca gcc ata ttt gtc tat gct gct acg tct cca gtg aat ggt tat ttt       1243
Thr Ala Ile Phe Val Tyr Ala Ala Thr Ser Pro Val Asn Gly Tyr Phe           
            330                 335                 340                   

gga gga agt ctg tat gct aga caa gga gga agg aga tgg ata aag cag       1291
Gly Gly Ser Leu Tyr Ala Arg Gln Gly Gly Arg Arg Trp Ile Lys Gln           
        345                 350                 355                       

atg ttt att ggg gca ttc ctt atc cca gct atg gtg tgt ggc act gcc       1339
Met Phe Ile Gly Ala Phe Leu Ile Pro Ala Met Val Cys Gly Thr Ala           
    360                 365                 370                           

ttc ttc atc aat ttc ata gcc att tat tac cat gct tca aga gcc att       1387
Phe Phe Ile Asn Phe Ile Ala Ile Tyr Tyr His Ala Ser Arg Ala Ile           
375                 380                 385                 390           

cct ttt gga aca atg gtg gcc gtt tgt tgc atc tgt ttt ttt gtt att       1435
Pro Phe Gly Thr Met Val Ala Val Cys Cys Ile Cys Phe Phe Val Ile           
                395                 400                 405               

ctt cct cta aat ctt gtt ggt aca ata ctt ggc cga aat ctg tca ggt       1483
Leu Pro Leu Asn Leu Val Gly Thr Ile Leu Gly Arg Asn Leu Ser Gly           
            410                 415                 420                   

cag ccc aac ttt cct tgt cgt gtc aat gct gtg cct cgt cct ata ccg       1531
Gln Pro Asn Phe Pro Cys Arg Val Asn Ala Val Pro Arg Pro Ile Pro           
        425                 430                 435                       

gag aaa aaa tgg ttc atg gag cct gcg gtt att gtt tgc ctg ggt gga       1579
Glu Lys Lys Trp Phe Met Glu Pro Ala Val Ile Val Cys Leu Gly Gly           
    440                 445                 450                           

att tta cct ttt ggt tca atc ttt att gaa atg tat ttc atc ttc acg       1627
Ile Leu Pro Phe Gly Ser Ile Phe Ile Glu Met Tyr Phe Ile Phe Thr           
455                 460                 465                 470           

tct ttc tgg gca tat aag atc tat tat gtc tat ggc ttc atg atg ctg       1675
Ser Phe Trp Ala Tyr Lys Ile Tyr Tyr Val Tyr Gly Phe Met Met Leu           
                475                 480                 485               

gtg ctg gtt atc ctg tgc att gtg act gtc tgt gtg act att gtg tgc       1723
Val Leu Val Ile Leu Cys Ile Val Thr Val Cys Val Thr Ile Val Cys           
            490                 495                 500                   

aca tat ttt cta cta aat gca gaa gat tac cgg tgg caa tgg aca agt       1771
Thr Tyr Phe Leu Leu Asn Ala Glu Asp Tyr Arg Trp Gln Trp Thr Ser           
        505                 510                 515                       

ttt ctc tct gct gca tca act gca atc tat gtt tac atg tat tcc ttt       1819
Phe Leu Ser Ala Ala Ser Thr Ala Ile Tyr Val Tyr Met Tyr Ser Phe           
    520                 525                 530                           

tac tac tat ttt ttc aaa aca aag atg tat ggc tta ttt caa aca tca       1867
Tyr Tyr Tyr Phe Phe Lys Thr Lys Met Tyr Gly Leu Phe Gln Thr Ser           
535                 540                 545                 550           

ttt tac ttt gga tat atg gcg gta ttt agc aca gcc ttg ggg ata atg       1915
Phe Tyr Phe Gly Tyr Met Ala Val Phe Ser Thr Ala Leu Gly Ile Met           
                555                 560                 565               

tgt gga gcg att ggt tac atg gga aca agt gcc ttt gtc cga aaa atc       1963
Cys Gly Ala Ile Gly Tyr Met Gly Thr Ser Ala Phe Val Arg Lys Ile           
            570                 575                 580                   

tat act aat gtg aaa att gac tag agacccaaga aaacctggaa ctttggatca      2017
Tyr Thr Asn Val Lys Ile Asp                                               
        585                                                               

atttcttttt cataggggtg gaacttgcac agcaaaaaca aacaaacgca agaagagatt     2077

tgggctttaa cacactgggt actttgtggg tctctctttc gtcggtggct taaagtaaca     2137

tctatttcca ttgatcctag gttcttcctg actgctttct ccaactgttc acagcaaatg     2197

cttggatttt atgcagtagg cattactaca gtacatggct aatcttccca aaaactagct     2257

cattaaagat gaaatagacc agctctcttc agtgaagagg acaaatagtt tatttaaagc     2317

atttgttcca ataaaataaa tagagggaaa cttggatgct aaaattacat gaataggaat     2377

cttcctggca cttagtgttt ctatgttatt gaaaaatgat gttccagaaa gattactttt     2437

ttcctcttat ttttactgcc attgtcgacc tattgtggga catttttata tattgaatct     2497

gggttctttt ttgacttttt ttttttccca atccaacagc atcctttttt ttaaaagaga     2557

gaattagaaa atattaaatc ctgcatgtaa tatatctgct gtcatcttag ttggaccaac     2617

ttcccattta tttatcttaa aactatacag ttacatctta attccatcca aagaagatac     2677

agtttgaaga cagaagtgta ctctctacaa tgcaatttac tgtacagtta gaaagcaaag     2737

tgttaaatgg agaagatact tgtttttatt aaacattttg agatttagat aaactacatt     2797

ttaactgaat gtctaaagtg attatctttt ttccccccaa gttagtctta aatcttttgg     2857

gtttgaatga aggttttaca taagaaatta ttaaaaacaa ggggggtggg taataaatgt     2917

atataacatt aaataatgta acgtaggtgt agattcccaa atgcatttgg atgtacagat     2977

cgactacaga gtactttttt cttatgatga ttggtgtaga aatgtgtgat ttgggtgggc     3037

ttttacatct tgcctaccat tgcatgaaac attggggttt cttcaaaatg tgtgtgtcat     3097

acttcttttg ggaggggggt tgttttcttc tgtttatttt ctgagactcc tacaggagcc     3157

aaatttgtaa tttagagaca cttaattttg ttaatcctgt ctgggacact taagtaacat     3217

ctaaagcatt attgctttag aatgttcaaa taaaatttcc tgaccaaatt gttttgtgga     3277

aatagatgtg tttgcaattt gaagatatct ttctgtccag aaggcaaaat taccgaatgc     3337

catttttaaa agtatgctat aaactatgct actctcatac aggggacccg tattttaaaa     3397

tctccagact tgcttacatc tagattatcc agcacaatca taaagtgaat gacaaaccct     3457

ttgaatgaaa ttgtggcaca aaatctgttc aggttggtgt accgtgtaaa gtggggatgg     3517

ggtaaaagtg gttaacgtac tgttggatca acaaataaag gttacagttt tgtaagagaa     3577

gtgatttgaa tacatttttc tggaactatt cataatatga agttttccta gaaccactga     3637

gtttctagtt taatagtttg ctatgcaaat gaccacctaa aacaatactt tatattgtta     3697

tttttagaaa gactcaaaac acctgtattt aaaccttaat atgaaaatca tgcaattaat     3757

agttacacaa gatgttttca ttacaaaata tgtacctatc tattgatgga ctctacatcc     3817

tatattgtga catgtaagtc ctttaaaagg tgaaaagtat gatttcttac cacttaagta     3877

tgattgatat gatccaacaa atttgatcag aagctgtagg taaatcctct tctgaagcca     3937

aaatggtata ttaaatataa tttattggta cttccatttt ctcttccttc ttacttgcct     3997

ttaagatctt ataaaaaaga aactaaaagt taatatttag ttgcctatat tatgtaacct     4057

tttaactata tataaagtac ttttttggtt tctttctcac cacttttatt caaaagtact     4117

tttaacatac caatacatag tctgtctgat gggagtataa attggacagt aaggttttgt     4177

cttaataaaa tgaaatttgt ttctcatgat atgaatcttg caggtaagat gtagggttta     4237

ttgaaaatgt gtgggttaaa tgctttcagg tacaccaatt ctttctacta aattgagctc     4297

tatttgaagt tctttggaat ctgtggtgaa aaataatttt ctgatttcca aatacattaa     4357

gagcattaaa tgaatattaa tcacctttaa agtcttttag aaaaggactt gtattggttt     4417

ttggctgcat agaggggttg aataagtgta tgtatgtgtg tgcgtgtgtg tgtgtcttct     4477

taaagaagat gtaattcaca aatagtttag ctccctagcg ctcagttgta gaatagaaaa     4537

tagaacatta ttcaagttaa ttgaaaggtg aggtttttat acccccacta atgctgtgta     4597

tctgtctttc gtttgttaac attatttgct taatttcttt caactcacac tttggataat     4657

actatcaaaa actaaggcta aacattcctt gtgtatcttt aagcatgctt ctcctgaaat     4717

ttaactacat tagtagttga catttgtata catatatcct aatacaagag taggataagg     4777

tggaaatgta atggcctgag ggatggtgaa gcattctttt agtatttttc atcatgttgg     4837

gctcctagat tgtactgggg ttgcccataa atcaaacccc atactcttag aattcattat     4897

attatggtga tatccgaacc tagtgaatgg tatgcttggg tgttttccat tgagagtgga     4957

tggacctctt tataaagttg gttgctgcaa aatccagttc ttccaaaagc cactttattt     5017

agggtttatt cacaagtcat atccattttg gtacagtgtt tgtttcctaa tatttattaa     5077

ccaccttata ccaaatgtct tgcaaagaaa tgttattaaa accttgaatt tttacaaatg     5137

taaaaaacaa aaagtgtatt aatgtatttg ttcaggaaaa gctacatacc gaagggcttt     5197

tgtatatgaa ttctgtggtg gggagaccca tttgtaatct atatggcagt tccatctggg     5257

ttttaagttt agatttcacc gtgtcttagt gcttcattct attggtttat tggaacatgt     5317

aataaatagg agtagtgatg tattaaaaca caagtattca ttaatgtttt atatcttcac     5377

taaaattcta tagttatgaa actatcaatc aaggtgttat atttcagtca gaagtgaaaa     5437

tttatgaaga gtatttggaa gtgtgtacag aaataaacta gacttacagg taggctagat     5497

cagaacgtta acatatgaac ctgcagaaat ctggtaagac ttaaattcag tgtgaggaat     5557

aactctagtt ctctcctatg agcatttcct aaaagccatc tgatttggca ttcttactgg     5617

agctgcagac agaaatctac aaagacaaaa gtaaacaaaa ttaagttatt attccactgt     5677

taggaatgga aataaacttg tgaagtctgt ttattttgaa gtattggtga actaggcttg     5737

ctaattgata actgcagcag tttgtgttta ctccagttca tcagcttagg tcatttgaaa     5797

gatataagag cttaaggcaa gaaagaaata acatggaatt ctatttgaag gacaacagaa     5857

cattcttgga aaagcagctc cagttggttt ttcaactgtc aaacttgaat gtgtaagtcc     5917

ccacagagca tggacagtcg gtgcagagtt ccaaggaaac aattattgcc tgatgaccac     5977

ttccattttg tatacactct ttggttcgta taggccatat tccaactggc tttttagtaa     6037

tagaaatcca gtatataatg tatcaaatac aattgaggtt ctaacctagt gtgttaattt     6097

atctgaattt ggatttttaa aaagtaataa aaagttaaat gta                       6140


<210>  8
<211>  589
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Arg Pro Leu Pro Gly Ala Leu Gly Val Ala Ala Ala Ala Ala Leu 
1               5                   10                  15      


Trp Leu Leu Leu Leu Leu Leu Pro Arg Thr Arg Ala Asp Glu His Glu 
            20                  25                  30          


His Thr Tyr Gln Asp Lys Glu Glu Val Val Leu Trp Met Asn Thr Val 
        35                  40                  45              


Gly Pro Tyr His Asn Arg Gln Glu Thr Tyr Lys Tyr Phe Ser Leu Pro 
    50                  55                  60                  


Phe Cys Val Gly Ser Lys Lys Ser Ile Ser His Tyr His Glu Thr Leu 
65                  70                  75                  80  


Gly Glu Ala Leu Gln Gly Val Glu Leu Glu Phe Ser Gly Leu Asp Ile 
                85                  90                  95      


Lys Phe Lys Asp Asp Val Met Pro Ala Thr Tyr Cys Glu Ile Asp Leu 
            100                 105                 110         


Asp Lys Glu Lys Arg Asp Ala Phe Val Tyr Ala Ile Lys Asn His Tyr 
        115                 120                 125             


Trp Tyr Gln Met Tyr Ile Asp Asp Leu Pro Ile Trp Gly Ile Val Gly 
    130                 135                 140                 


Glu Ala Asp Glu Asn Gly Glu Asp Tyr Tyr Leu Trp Thr Tyr Lys Lys 
145                 150                 155                 160 


Leu Glu Ile Gly Phe Asn Gly Asn Arg Ile Val Asp Val Asn Leu Thr 
                165                 170                 175     


Ser Glu Gly Lys Val Lys Leu Val Pro Asn Thr Lys Ile Gln Met Ser 
            180                 185                 190         


Tyr Ser Val Lys Trp Lys Lys Ser Asp Val Lys Phe Glu Asp Arg Phe 
        195                 200                 205             


Asp Lys Tyr Leu Asp Pro Ser Phe Phe Gln His Arg Ile His Trp Phe 
    210                 215                 220                 


Ser Ile Phe Asn Ser Phe Met Met Val Ile Phe Leu Val Gly Leu Val 
225                 230                 235                 240 


Ser Met Ile Leu Met Arg Thr Leu Arg Lys Asp Tyr Ala Arg Tyr Ser 
                245                 250                 255     


Lys Glu Glu Glu Met Asp Asp Met Asp Arg Asp Leu Gly Asp Glu Tyr 
            260                 265                 270         


Gly Trp Lys Gln Val His Gly Asp Val Phe Arg Pro Ser Ser His Pro 
        275                 280                 285             


Leu Ile Phe Ser Ser Leu Ile Gly Ser Gly Cys Gln Ile Phe Ala Val 
    290                 295                 300                 


Ser Leu Ile Val Ile Ile Val Ala Met Ile Glu Asp Leu Tyr Thr Glu 
305                 310                 315                 320 


Arg Gly Ser Met Leu Ser Thr Ala Ile Phe Val Tyr Ala Ala Thr Ser 
                325                 330                 335     


Pro Val Asn Gly Tyr Phe Gly Gly Ser Leu Tyr Ala Arg Gln Gly Gly 
            340                 345                 350         


Arg Arg Trp Ile Lys Gln Met Phe Ile Gly Ala Phe Leu Ile Pro Ala 
        355                 360                 365             


Met Val Cys Gly Thr Ala Phe Phe Ile Asn Phe Ile Ala Ile Tyr Tyr 
    370                 375                 380                 


His Ala Ser Arg Ala Ile Pro Phe Gly Thr Met Val Ala Val Cys Cys 
385                 390                 395                 400 


Ile Cys Phe Phe Val Ile Leu Pro Leu Asn Leu Val Gly Thr Ile Leu 
                405                 410                 415     


Gly Arg Asn Leu Ser Gly Gln Pro Asn Phe Pro Cys Arg Val Asn Ala 
            420                 425                 430         


Val Pro Arg Pro Ile Pro Glu Lys Lys Trp Phe Met Glu Pro Ala Val 
        435                 440                 445             


Ile Val Cys Leu Gly Gly Ile Leu Pro Phe Gly Ser Ile Phe Ile Glu 
    450                 455                 460                 


Met Tyr Phe Ile Phe Thr Ser Phe Trp Ala Tyr Lys Ile Tyr Tyr Val 
465                 470                 475                 480 


Tyr Gly Phe Met Met Leu Val Leu Val Ile Leu Cys Ile Val Thr Val 
                485                 490                 495     


Cys Val Thr Ile Val Cys Thr Tyr Phe Leu Leu Asn Ala Glu Asp Tyr 
            500                 505                 510         


Arg Trp Gln Trp Thr Ser Phe Leu Ser Ala Ala Ser Thr Ala Ile Tyr 
        515                 520                 525             


Val Tyr Met Tyr Ser Phe Tyr Tyr Tyr Phe Phe Lys Thr Lys Met Tyr 
    530                 535                 540                 


Gly Leu Phe Gln Thr Ser Phe Tyr Phe Gly Tyr Met Ala Val Phe Ser 
545                 550                 555                 560 


Thr Ala Leu Gly Ile Met Cys Gly Ala Ile Gly Tyr Met Gly Thr Ser 
                565                 570                 575     


Ala Phe Val Arg Lys Ile Tyr Thr Asn Val Lys Ile Asp 
            580                 585                 


<210>  9
<211>  3996
<212>  DNA
<213>  Homo sapiens


<220>
<221>  CDS
<222>  (236)..(2164)

<400>  9
agtttctgcc aggagctaat atggcttcct tagttacacc gttctctctc ttcacctaat       60

cagcgacctt actttcccag accagactgt cgagcaggag ctaagactcc ttttcccctc      120

tgctgaccgc cactacagga gcggttgaag ccagacgacc accttgtgga gttaaactcc      180

gtaaccaggg agcaccactt ccgctgacgt cattacggcg acacgtggat ccaag atg       238
                                                             Met          
                                                             1            

gcg acg gcg atg gat tgg ttg ccg tgg tct tta ctg ctt ttc tcc ctg        286
Ala Thr Ala Met Asp Trp Leu Pro Trp Ser Leu Leu Leu Phe Ser Leu           
            5                   10                  15                    

atg tgt gaa aca agc gcc ttc tat gtg cct ggg gtc gcg cct atc aac        334
Met Cys Glu Thr Ser Ala Phe Tyr Val Pro Gly Val Ala Pro Ile Asn           
        20                  25                  30                        

ttc cac cag aac gat ccc gta gaa atc aag gct gtg aag ctc acc agc        382
Phe His Gln Asn Asp Pro Val Glu Ile Lys Ala Val Lys Leu Thr Ser           
    35                  40                  45                            

tct cga acc cag cta cct tat gaa tac tat tca ctg ccc ttc tgc cag        430
Ser Arg Thr Gln Leu Pro Tyr Glu Tyr Tyr Ser Leu Pro Phe Cys Gln           
50                  55                  60                  65            

ccc agc aag ata acc tac aag gca gag aat ctg gga gag gtg ctg aga        478
Pro Ser Lys Ile Thr Tyr Lys Ala Glu Asn Leu Gly Glu Val Leu Arg           
                70                  75                  80                

ggg gac cgg att gtc aac acc cct ttc cag gtt ctc atg aac agc gag        526
Gly Asp Arg Ile Val Asn Thr Pro Phe Gln Val Leu Met Asn Ser Glu           
            85                  90                  95                    

aag aag tgt gaa gtt ctg tgc agc cag tcc aac aag cca gtg acc ctg        574
Lys Lys Cys Glu Val Leu Cys Ser Gln Ser Asn Lys Pro Val Thr Leu           
        100                 105                 110                       

aca gtg gag cag agc cga ctc gtg gcc gag cgg atc aca gaa gac tac        622
Thr Val Glu Gln Ser Arg Leu Val Ala Glu Arg Ile Thr Glu Asp Tyr           
    115                 120                 125                           

tac gtc cac ctc att gct gac aac ctg cct gtg gcc acc cgg ctg gag        670
Tyr Val His Leu Ile Ala Asp Asn Leu Pro Val Ala Thr Arg Leu Glu           
130                 135                 140                 145           

ctc tac tcc aac cga gac agc gat gac aag aag aag gaa aaa gat gtg        718
Leu Tyr Ser Asn Arg Asp Ser Asp Asp Lys Lys Lys Glu Lys Asp Val           
                150                 155                 160               

cag ttt gaa cac ggc tac cgg ctc ggc ttc aca gat gtc aac aag atc        766
Gln Phe Glu His Gly Tyr Arg Leu Gly Phe Thr Asp Val Asn Lys Ile           
            165                 170                 175                   

tac ctg cac aac cac ctc tca ttc atc ctt tac tat cat cgg gag gac        814
Tyr Leu His Asn His Leu Ser Phe Ile Leu Tyr Tyr His Arg Glu Asp           
        180                 185                 190                       

atg gaa gag gac cag gag cac acg tac cgt gtc gtc cgc ttc gag gtg        862
Met Glu Glu Asp Gln Glu His Thr Tyr Arg Val Val Arg Phe Glu Val           
    195                 200                 205                           

att ccc cag agc atc agg ctg gag gac ctc aaa gca gat gag aag agt        910
Ile Pro Gln Ser Ile Arg Leu Glu Asp Leu Lys Ala Asp Glu Lys Ser           
210                 215                 220                 225           

tcg tgc act ctg cct gag ggt acc aac tcc tcg ccc caa gaa att gac        958
Ser Cys Thr Leu Pro Glu Gly Thr Asn Ser Ser Pro Gln Glu Ile Asp           
                230                 235                 240               

ccc acc aag gag aat cag ctg tac ttc acc tac tct gtc cac tgg gag       1006
Pro Thr Lys Glu Asn Gln Leu Tyr Phe Thr Tyr Ser Val His Trp Glu           
            245                 250                 255                   

gaa agt gat atc aaa tgg gcc tct cgc tgg gac act tac ctg acc atg       1054
Glu Ser Asp Ile Lys Trp Ala Ser Arg Trp Asp Thr Tyr Leu Thr Met           
        260                 265                 270                       

agt gac gtc cag atc cac tgg ttt tct atc att aac tcc gtt gtt gtg       1102
Ser Asp Val Gln Ile His Trp Phe Ser Ile Ile Asn Ser Val Val Val           
    275                 280                 285                           

gtc ttc ttc ctg tca ggt atc ctg agc atg att atc att cgg acc ctc       1150
Val Phe Phe Leu Ser Gly Ile Leu Ser Met Ile Ile Ile Arg Thr Leu           
290                 295                 300                 305           

cgg aag gac att gcc aac tac aac aag gag gat gac att gaa gac acc       1198
Arg Lys Asp Ile Ala Asn Tyr Asn Lys Glu Asp Asp Ile Glu Asp Thr           
                310                 315                 320               

atg gag gag tct ggg tgg aag ttg gtg cac ggc gac gtc ttc agg ccc       1246
Met Glu Glu Ser Gly Trp Lys Leu Val His Gly Asp Val Phe Arg Pro           
            325                 330                 335                   

ccc cag tac ccc atg atc ctc agc tcc ctg ctg ggc tca ggc att cag       1294
Pro Gln Tyr Pro Met Ile Leu Ser Ser Leu Leu Gly Ser Gly Ile Gln           
        340                 345                 350                       

ctg ttc tgt atg atc ctc atc gtc atc ttt gta gcc atg ctt ggg atg       1342
Leu Phe Cys Met Ile Leu Ile Val Ile Phe Val Ala Met Leu Gly Met           
    355                 360                 365                           

ctg tcg ccc tcc agc cgg gga gct ctc atg acc aca gcc tgc ttc ctc       1390
Leu Ser Pro Ser Ser Arg Gly Ala Leu Met Thr Thr Ala Cys Phe Leu           
370                 375                 380                 385           

ttc atg ttc atg ggg gtg ttt ggc gga ttt tct gct ggc cgt ctg tac       1438
Phe Met Phe Met Gly Val Phe Gly Gly Phe Ser Ala Gly Arg Leu Tyr           
                390                 395                 400               

cgc act tta aaa ggc cat cgg tgg aag aaa gga gcc ttc tgt acg gca       1486
Arg Thr Leu Lys Gly His Arg Trp Lys Lys Gly Ala Phe Cys Thr Ala           
            405                 410                 415                   

act ctg tac cct ggt gtg gtt ttt ggc atc tgc ttc gta ttg aat tgc       1534
Thr Leu Tyr Pro Gly Val Val Phe Gly Ile Cys Phe Val Leu Asn Cys           
        420                 425                 430                       

ttc att tgg gga aag cac tca tca gga gcg gtg ccc ttt ccc acc atg       1582
Phe Ile Trp Gly Lys His Ser Ser Gly Ala Val Pro Phe Pro Thr Met           
    435                 440                 445                           

gtg gct ctg ctg tgc atg tgg ttc ggg atc tcc ctg ccc ctc gtc tac       1630
Val Ala Leu Leu Cys Met Trp Phe Gly Ile Ser Leu Pro Leu Val Tyr           
450                 455                 460                 465           

ttg ggc tac tac ttc ggc ttc cga aag cag cca tat gac aac cct gtg       1678
Leu Gly Tyr Tyr Phe Gly Phe Arg Lys Gln Pro Tyr Asp Asn Pro Val           
                470                 475                 480               

cgc acc aac cag att ccc cgg cag atc ccc gag cag cgg tgg tac atg       1726
Arg Thr Asn Gln Ile Pro Arg Gln Ile Pro Glu Gln Arg Trp Tyr Met           
            485                 490                 495                   

aac cga ttt gtg ggc atc ctc atg gct ggg atc ttg ccc ttc ggc gcc       1774
Asn Arg Phe Val Gly Ile Leu Met Ala Gly Ile Leu Pro Phe Gly Ala           
        500                 505                 510                       

atg ttc atc gag ctc ttc ttc atc ttc agt gct atc tgg gag aat cag       1822
Met Phe Ile Glu Leu Phe Phe Ile Phe Ser Ala Ile Trp Glu Asn Gln           
    515                 520                 525                           

ttc tat tac ctc ttt ggc ttc ctg ttc ctt gtt ttc atc atc ctg gtg       1870
Phe Tyr Tyr Leu Phe Gly Phe Leu Phe Leu Val Phe Ile Ile Leu Val           
530                 535                 540                 545           

gta tcc tgt tca caa atc agc atc gtc atg gtg tac ttc cag ctg tgt       1918
Val Ser Cys Ser Gln Ile Ser Ile Val Met Val Tyr Phe Gln Leu Cys           
                550                 555                 560               

gca gag gat tac cgc tgg tgg tgg aga aat ttc cta gtc tcc ggg ggc       1966
Ala Glu Asp Tyr Arg Trp Trp Trp Arg Asn Phe Leu Val Ser Gly Gly           
            565                 570                 575                   

tct gca ttc tac gtc ctg gtt tat gcc atc ttt tat ttc gtt aac aag       2014
Ser Ala Phe Tyr Val Leu Val Tyr Ala Ile Phe Tyr Phe Val Asn Lys           
        580                 585                 590                       

ctg gac atc gtg gag ttc atc ccc tct ctc ctc tac ttt ggc tac acg       2062
Leu Asp Ile Val Glu Phe Ile Pro Ser Leu Leu Tyr Phe Gly Tyr Thr           
    595                 600                 605                           

gcc ctc atg gtc ttg tcc ttc tgg ctg cta acg ggt acc atc ggc ttc       2110
Ala Leu Met Val Leu Ser Phe Trp Leu Leu Thr Gly Thr Ile Gly Phe           
610                 615                 620                 625           

tat gca gcc tac atg ttt gtt cgc aag atc tat gct gct gtg aag ata       2158
Tyr Ala Ala Tyr Met Phe Val Arg Lys Ile Tyr Ala Ala Val Lys Ile           
                630                 635                 640               

gac tga ttggagtgga ccacggccaa gcttgctccg tcctcggaca ggaagccacc        2214
Asp                                                                       
                                                                          

ctgcgtgggg gactgcaggc acgcaaaata aaataactcc tgctcgtttg gaatgtaact     2274

cctggcacag tgttcctgga tcctggggct gcgtgggggg cgggagggcc tgtagataat     2334

cttgcgtttt tcgtcatctt attccagttc tgtgggggat gagttttttt gtgggttgct     2394

ttttcttcag tgctaagaaa gttccctcca acaggaactc tctgacctgt ttattcaggt     2454

gtatttctgg tttggatttt tttttccttc tttgttttaa caaatggatc caggatggat     2514

aaatccaccg agataagggt tttggtcact gtctccacct cagttcctca gggctgttgg     2574

ccaccctatg actaactgga agaggacacg ccagagcttc agtgaggttt ccgagcctct     2634

ccctgcccat cctcaccact gaggccacga caaagcacag ctccagctcg gacagcaccc     2694

tcagtgccag ccagcctctg ccagacctct ctttccctct tctccccagc ctcctccagg     2754

gctgcccaag gcagggtttc cagccaggcc tcggggtcat cttttcacca ggagcaaacc     2814

caagtcttag ttgctacaag aaaatcccct ggaagtactg ggggccaggt tccccagaca     2874

gcaggaattg cccctgttca gagcagccgg agtttgctgg accacaagga agaagagaag     2934

agacttgcag tgaactgttt ttgtgccaag aaaccctgga cctggggcca agtatttccc     2994

aagccaagca tccacttgtc tgtgtctggg aagggatggc caaggccgct agggtcctta     3054

cccctcagga tcactcccca gccctttcct caggaggtac cgctctccaa ggtgtgctag     3114

cagtgggccc tgcccaactt caggcagaac agggaggccc agagattaca gatcccctcc     3174

tgtaagtggc caggcattct ctccctgccc tctctggcct ctggggtcat actcacttct     3234

ttagccagcc ccatcccctc caccccacac ctgagttctt gcctcctcct tttggggaca     3294

cccaaaacac tgcttgtgag aaggaagatg gaaggtaagt tctgtcgttc tttccccaat     3354

ccccaggaat ggacaagaag ccaacttaga aagaagggtc tcacgtggct ggcctggctc     3414

ctccgtagac ccctgttctt ttcaacctct gcccacccgt gcatgtcatc acaaacattt     3474

gctcttaagt tacaagagac cacatccacc cagggattag ggttcaagta gcagctgcta     3534

acccttgcac cagcccttgt gggactccca acacaagaca aagctcagga tgctggtgat     3594

gctaggaaga tgtccctccc ctcactgccc cacattctcc cagtggctct accagcctca     3654

cccatcaaac cagtgaattt ctcaatcttg cctcacagtg actgcagcgc caagcggcat     3714

ccaccaagca tcaagttgga gaaaagggaa cccaagcagt agagagcgat attggagtct     3774

tttgttcatt caaatcttgg attttttttt ttccctaaga gattctcttt ttagggggaa     3834

tgggaaacgg acacctcata aagggttcaa agatcatcaa tttttctgac tttttaaatc     3894

attatcatta ttatttttaa ttaaaaaaat gcctgtatgc ctttttttgg tcggattgta     3954

aataaatata ccattgtcct actgaaaaaa aaaaaaaaaa aa                        3996


<210>  10
<211>  642
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Thr Ala Met Asp Trp Leu Pro Trp Ser Leu Leu Leu Phe Ser 
1               5                   10                  15      


Leu Met Cys Glu Thr Ser Ala Phe Tyr Val Pro Gly Val Ala Pro Ile 
            20                  25                  30          


Asn Phe His Gln Asn Asp Pro Val Glu Ile Lys Ala Val Lys Leu Thr 
        35                  40                  45              


Ser Ser Arg Thr Gln Leu Pro Tyr Glu Tyr Tyr Ser Leu Pro Phe Cys 
    50                  55                  60                  


Gln Pro Ser Lys Ile Thr Tyr Lys Ala Glu Asn Leu Gly Glu Val Leu 
65                  70                  75                  80  


Arg Gly Asp Arg Ile Val Asn Thr Pro Phe Gln Val Leu Met Asn Ser 
                85                  90                  95      


Glu Lys Lys Cys Glu Val Leu Cys Ser Gln Ser Asn Lys Pro Val Thr 
            100                 105                 110         


Leu Thr Val Glu Gln Ser Arg Leu Val Ala Glu Arg Ile Thr Glu Asp 
        115                 120                 125             


Tyr Tyr Val His Leu Ile Ala Asp Asn Leu Pro Val Ala Thr Arg Leu 
    130                 135                 140                 


Glu Leu Tyr Ser Asn Arg Asp Ser Asp Asp Lys Lys Lys Glu Lys Asp 
145                 150                 155                 160 


Val Gln Phe Glu His Gly Tyr Arg Leu Gly Phe Thr Asp Val Asn Lys 
                165                 170                 175     


Ile Tyr Leu His Asn His Leu Ser Phe Ile Leu Tyr Tyr His Arg Glu 
            180                 185                 190         


Asp Met Glu Glu Asp Gln Glu His Thr Tyr Arg Val Val Arg Phe Glu 
        195                 200                 205             


Val Ile Pro Gln Ser Ile Arg Leu Glu Asp Leu Lys Ala Asp Glu Lys 
    210                 215                 220                 


Ser Ser Cys Thr Leu Pro Glu Gly Thr Asn Ser Ser Pro Gln Glu Ile 
225                 230                 235                 240 


Asp Pro Thr Lys Glu Asn Gln Leu Tyr Phe Thr Tyr Ser Val His Trp 
                245                 250                 255     


Glu Glu Ser Asp Ile Lys Trp Ala Ser Arg Trp Asp Thr Tyr Leu Thr 
            260                 265                 270         


Met Ser Asp Val Gln Ile His Trp Phe Ser Ile Ile Asn Ser Val Val 
        275                 280                 285             


Val Val Phe Phe Leu Ser Gly Ile Leu Ser Met Ile Ile Ile Arg Thr 
    290                 295                 300                 


Leu Arg Lys Asp Ile Ala Asn Tyr Asn Lys Glu Asp Asp Ile Glu Asp 
305                 310                 315                 320 


Thr Met Glu Glu Ser Gly Trp Lys Leu Val His Gly Asp Val Phe Arg 
                325                 330                 335     


Pro Pro Gln Tyr Pro Met Ile Leu Ser Ser Leu Leu Gly Ser Gly Ile 
            340                 345                 350         


Gln Leu Phe Cys Met Ile Leu Ile Val Ile Phe Val Ala Met Leu Gly 
        355                 360                 365             


Met Leu Ser Pro Ser Ser Arg Gly Ala Leu Met Thr Thr Ala Cys Phe 
    370                 375                 380                 


Leu Phe Met Phe Met Gly Val Phe Gly Gly Phe Ser Ala Gly Arg Leu 
385                 390                 395                 400 


Tyr Arg Thr Leu Lys Gly His Arg Trp Lys Lys Gly Ala Phe Cys Thr 
                405                 410                 415     


Ala Thr Leu Tyr Pro Gly Val Val Phe Gly Ile Cys Phe Val Leu Asn 
            420                 425                 430         


Cys Phe Ile Trp Gly Lys His Ser Ser Gly Ala Val Pro Phe Pro Thr 
        435                 440                 445             


Met Val Ala Leu Leu Cys Met Trp Phe Gly Ile Ser Leu Pro Leu Val 
    450                 455                 460                 


Tyr Leu Gly Tyr Tyr Phe Gly Phe Arg Lys Gln Pro Tyr Asp Asn Pro 
465                 470                 475                 480 


Val Arg Thr Asn Gln Ile Pro Arg Gln Ile Pro Glu Gln Arg Trp Tyr 
                485                 490                 495     


Met Asn Arg Phe Val Gly Ile Leu Met Ala Gly Ile Leu Pro Phe Gly 
            500                 505                 510         


Ala Met Phe Ile Glu Leu Phe Phe Ile Phe Ser Ala Ile Trp Glu Asn 
        515                 520                 525             


Gln Phe Tyr Tyr Leu Phe Gly Phe Leu Phe Leu Val Phe Ile Ile Leu 
    530                 535                 540                 


Val Val Ser Cys Ser Gln Ile Ser Ile Val Met Val Tyr Phe Gln Leu 
545                 550                 555                 560 


Cys Ala Glu Asp Tyr Arg Trp Trp Trp Arg Asn Phe Leu Val Ser Gly 
                565                 570                 575     


Gly Ser Ala Phe Tyr Val Leu Val Tyr Ala Ile Phe Tyr Phe Val Asn 
            580                 585                 590         


Lys Leu Asp Ile Val Glu Phe Ile Pro Ser Leu Leu Tyr Phe Gly Tyr 
        595                 600                 605             


Thr Ala Leu Met Val Leu Ser Phe Trp Leu Leu Thr Gly Thr Ile Gly 
    610                 615                 620                 


Phe Tyr Ala Ala Tyr Met Phe Val Arg Lys Ile Tyr Ala Ala Val Lys 
625                 630                 635                 640 


Ile Asp 
        


<210>  11
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct:  oligonucleotide useful as a primer.

<400>  11
gatatacata tggctagcat ggcgacggcg atggat                                 36


<210>  12
<211>  36
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Synthetic construct:  oligonucleotide useful as a primer.

<400>  12
ttgttagcag ccggatcctc agtctatctt cacagc                                 36


<210>  13
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  13

Met Thr Val Val Gly Asn Pro Arg Ser Trp Ser Cys Gln Trp Leu Pro 
1               5                   10                  15      


Ile Leu Ile Leu Leu Leu Gly Thr Gly His Gly Pro Gly Val Glu Gly 
            20                  25                  30          


Val Thr His Tyr Lys Ala Gly Asp Pro Val Ile Leu Tyr Val Asn Lys 
        35                  40                  45              


Val Gly Pro Tyr His Asn Pro Gln Glu Thr Tyr His Tyr Tyr Gln Leu 
    50                  55                  60                  


Pro Val Cys Cys Pro Glu Lys Ile Arg His Lys Ser Leu Ser Leu Gly 
65                  70                  75                  80  


Glu Val Leu Asp Gly Asp Arg Met Ala Glu Ser Leu Tyr Glu Ile Arg 
                85                  90                  95      


Phe Arg Glu Asn Val Glu Lys Arg Ile Leu Cys His Met Gln Leu Ser 
            100                 105                 110         


Ser Ala Gln Val Glu Gln Leu Arg Gln Ala Ile Glu Glu Leu Tyr Tyr 
        115                 120                 125             


Phe Glu Phe Val Val Asp Asp Leu Pro Ile Arg Gly Phe Val Gly Tyr 
    130                 135                 140                 


Met Glu Glu Ser Gly Phe Leu Pro His Ser His Lys Ile Gly Leu Trp 
145                 150                 155                 160 


Thr His Leu Asp Phe His Leu Glu Phe His Gly Asp Arg Ile Ile Phe 
                165                 170                 175     


Ala Asn Val Ser Val Arg Asp Val Lys Pro His Ser Leu Asp Gly Leu 
            180                 185                 190         


Arg Pro Asp Glu Phe Leu Gly Leu Thr His Thr Tyr Ser Val Arg Trp 
        195                 200                 205             


Ser Glu Thr Ser Val Glu Arg Arg Ser Asp Arg Arg Arg Gly Asp Asp 
    210                 215                 220                 


Gly Gly Phe Phe Pro Arg Thr Leu Glu Ile His Trp Leu 
225                 230                 235         


<210>  14
<211>  237
<212>  PRT
<213>  Homo sapiens

<400>  14

Met Thr Val Val Gly Asn Pro Arg Ser Trp Ser Cys Gln Trp Leu Pro 
1               5                   10                  15      


Ile Leu Ile Leu Leu Leu Gly Thr Gly His Gly Pro Gly Val Glu Gly 
            20                  25                  30          


Val Thr His Tyr Lys Ala Gly Asp Pro Val Ile Leu Tyr Val Asn Lys 
        35                  40                  45              


Val Gly Pro Tyr His Asn Pro Gln Glu Thr Tyr His Tyr Tyr Gln Leu 
    50                  55                  60                  


Pro Val Cys Cys Pro Glu Lys Ile Arg His Lys Ser Leu Ser Leu Gly 
65                  70                  75                  80  


Glu Val Leu Asp Gly Asp Arg Met Ala Glu Ser Leu Tyr Glu Ile Arg 
                85                  90                  95      


Phe Arg Glu Asn Val Glu Lys Arg Ile Leu Cys His Met Gln Leu Ser 
            100                 105                 110         


Ser Ala Gln Val Glu Gln Leu Arg Gln Ala Ile Glu Glu Leu Tyr Tyr 
        115                 120                 125             


Phe Glu Phe Val Val Asp Asp Leu Pro Ile Arg Gly Phe Val Gly Tyr 
    130                 135                 140                 


Met Glu Glu Ser Gly Phe Leu Pro His Ser His Lys Ile Gly Leu Trp 
145                 150                 155                 160 


Thr His Leu Asp Phe His Leu Glu Phe His Gly Asp Arg Ile Ile Phe 
                165                 170                 175     


Ala Asn Val Ser Val Arg Asp Val Lys Pro His Ser Leu Asp Gly Leu 
            180                 185                 190         


Arg Pro Asp Glu Phe Leu Gly Leu Thr His Thr Tyr Ser Val Arg Trp 
        195                 200                 205             


Ser Glu Thr Ser Val Glu Arg Arg Ser Asp Arg Arg Arg Gly Asp Asp 
    210                 215                 220                 


Gly Gly Phe Phe Pro Arg Thr Leu Glu Ile His Trp Leu 
225                 230                 235         


<210>  15
<211>  250
<212>  PRT
<213>  Homo sapiens

<400>  15

Met Ser Ala Arg Leu Pro Val Leu Ser Pro Pro Arg Trp Pro Arg Leu 
1               5                   10                  15      


Leu Leu Leu Ser Leu Leu Leu Leu Gly Ala Val Pro Gly Pro Arg Arg 
            20                  25                  30          


Ser Gly Ala Phe Tyr Leu Pro Gly Leu Ala Pro Val Asn Phe Cys Asp 
        35                  40                  45              


Glu Glu Lys Lys Ser Asp Glu Cys Lys Ala Glu Ile Glu Leu Phe Val 
    50                  55                  60                  


Asn Arg Leu Asp Ser Val Glu Ser Val Leu Pro Tyr Glu Tyr Thr Ala 
65                  70                  75                  80  


Phe Asp Phe Cys Gln Ala Ser Glu Gly Lys Arg Pro Ser Glu Asn Leu 
                85                  90                  95      


Gly Gln Val Leu Phe Gly Glu Arg Ile Glu Pro Ser Pro Tyr Lys Phe 
            100                 105                 110         


Thr Phe Asn Lys Lys Glu Thr Cys Lys Leu Val Cys Thr Lys Thr Tyr 
        115                 120                 125             


His Thr Glu Lys Ala Glu Asp Lys Gln Lys Leu Glu Phe Leu Lys Lys 
    130                 135                 140                 


Ser Met Leu Leu Asn Tyr Gln His His Trp Ile Val Asp Asn Met Pro 
145                 150                 155                 160 


Val Thr Trp Cys Tyr Asp Val Glu Asp Gly Gln Arg Phe Cys Asn Pro 
                165                 170                 175     


Gly Phe Pro Ile Gly Cys Tyr Ile Thr Asp Lys Gly His Ala Lys Asp 
            180                 185                 190         


Ala Cys Val Ile Ser Ser Asp Phe His Glu Arg Asp Thr Phe Tyr Ile 
        195                 200                 205             


Phe Asn His Val Asp Ile Lys Ile Tyr Tyr His Val Val Glu Thr Gly 
    210                 215                 220                 


Ser Met Gly Ala Arg Leu Val Ala Ala Lys Leu Glu Pro Lys Ser Phe 
225                 230                 235                 240 


Lys His Thr His Ile Asp Lys Pro Asp Cys 
                245                 250 


<210>  16
<211>  240
<212>  PRT
<213>  Homo sapiens

<400>  16

Met Arg Pro Leu Pro Gly Ala Leu Gly Val Ala Ala Ala Ala Ala Leu 
1               5                   10                  15      


Trp Leu Leu Leu Leu Leu Leu Pro Arg Thr Arg Ala Asp Glu His Glu 
            20                  25                  30          


His Thr Tyr Gln Asp Lys Glu Glu Val Val Leu Trp Met Asn Thr Val 
        35                  40                  45              


Gly Pro Tyr His Asn Arg Gln Glu Thr Tyr Lys Tyr Phe Ser Leu Pro 
    50                  55                  60                  


Phe Cys Val Gly Ser Lys Lys Ser Ile Ser His Tyr His Glu Thr Leu 
65                  70                  75                  80  


Gly Glu Ala Leu Gln Gly Val Glu Leu Glu Phe Ser Gly Leu Asp Ile 
                85                  90                  95      


Lys Phe Lys Asp Asp Val Met Pro Ala Thr Tyr Cys Glu Ile Asp Leu 
            100                 105                 110         


Asp Lys Glu Lys Arg Asp Ala Phe Val Tyr Ala Ile Lys Asn His Tyr 
        115                 120                 125             


Trp Tyr Gln Met Tyr Ile Asp Asp Leu Pro Ile Trp Gly Ile Val Gly 
    130                 135                 140                 


Glu Ala Asp Glu Asn Gly Glu Asp Tyr Tyr Leu Trp Thr Tyr Lys Lys 
145                 150                 155                 160 


Leu Glu Ile Gly Phe Asn Gly Asn Arg Ile Val Asp Val Asn Leu Thr 
                165                 170                 175     


Ser Glu Gly Lys Val Lys Leu Val Pro Asn Thr Lys Ile Gln Met Ser 
            180                 185                 190         


Tyr Ser Val Lys Trp Lys Lys Ser Asp Val Lys Phe Glu Asp Arg Phe 
        195                 200                 205             


Asp Lys Tyr Leu Asp Pro Ser Phe Phe Gln His Arg Ile His Trp Phe 
    210                 215                 220                 


Ser Ile Phe Asn Ser Phe Met Met Val Ile Phe Leu Val Gly Leu Val 
225                 230                 235                 240 


<210>  17
<211>  252
<212>  PRT
<213>  Homo sapiens

<400>  17

Met Ala Thr Ala Met Asp Trp Leu Pro Trp Ser Leu Leu Leu Phe Ser 
1               5                   10                  15      


Leu Met Cys Glu Thr Ser Ala Phe Tyr Val Pro Gly Val Ala Pro Ile 
            20                  25                  30          


Asn Phe His Gln Asn Asp Pro Val Glu Ile Lys Ala Val Lys Leu Thr 
        35                  40                  45              


Ser Ser Arg Thr Gln Leu Pro Tyr Glu Tyr Tyr Ser Leu Pro Phe Cys 
    50                  55                  60                  


Gln Pro Ser Lys Ile Thr Tyr Lys Ala Glu Asn Leu Gly Glu Val Leu 
65                  70                  75                  80  


Arg Gly Asp Arg Ile Val Asn Thr Pro Phe Gln Val Leu Met Asn Ser 
                85                  90                  95      


Glu Lys Lys Cys Glu Val Leu Cys Ser Gln Ser Asn Lys Pro Val Thr 
            100                 105                 110         


Leu Thr Val Glu Gln Ser Arg Leu Val Ala Glu Arg Ile Thr Glu Asp 
        115                 120                 125             


Tyr Tyr Val His Leu Ile Ala Asp Asn Leu Pro Val Ala Thr Arg Leu 
    130                 135                 140                 


Glu Leu Tyr Ser Asn Arg Asp Ser Asp Asp Lys Lys Lys Glu Lys Asp 
145                 150                 155                 160 


Val Gln Phe Glu His Gly Tyr Arg Leu Gly Phe Thr Asp Val Asn Lys 
                165                 170                 175     


Ile Tyr Leu His Asn His Leu Ser Phe Ile Leu Tyr Tyr His Arg Glu 
            180                 185                 190         


Asp Met Glu Glu Asp Gln Glu His Thr Tyr Arg Val Val Arg Phe Glu 
        195                 200                 205             


Val Ile Pro Gln Ser Ile Arg Leu Glu Asp Leu Lys Ala Asp Glu Lys 
    210                 215                 220                 


Ser Ser Cys Thr Leu Pro Glu Gly Thr Asn Ser Ser Pro Gln Glu Ile 
225                 230                 235                 240 


Asp Pro Thr Lys Glu Asn Gln Leu Tyr Phe Thr Tyr 
                245                 250         


