                         SEQUENCE LISTING

<110>  Tufts University
       President and Fellows of Harvard College
 
<120>  SMALL MOLECULE ANTAGONISTS OF 
       PHOSPHATIDYLINOSITOL-3,4,5-TRIPHOSPHATE (PIP3) AND USES THEREOF

<130>  T0605.70013

<150>  US 61/179,210
<151>  2009-05-18

<160>  1     

<170>  PatentIn version 3.5

<210>  1
<211>  480
<212>  PRT
<213>  Homo sapiens

<400>  1

Met Ser Asp Val Ala Ile Val Lys Glu Gly Trp Leu His Lys Arg Gly 
1               5                   10                  15      


Glu Tyr Ile Lys Thr Trp Arg Pro Arg Tyr Phe Leu Leu Lys Asn Asp 
            20                  25                  30          


Gly Thr Phe Ile Gly Tyr Lys Glu Arg Pro Gln Asp Val Asp Gln Arg 
        35                  40                  45              


Glu Ala Pro Leu Asn Asn Phe Ser Val Ala Gln Cys Gln Leu Met Lys 
    50                  55                  60                  


Thr Glu Arg Pro Arg Pro Asn Thr Phe Ile Ile Arg Cys Leu Gln Trp 
65                  70                  75                  80  


Thr Thr Val Ile Glu Arg Thr Phe His Val Glu Thr Pro Glu Glu Arg 
                85                  90                  95      


Glu Glu Trp Thr Thr Ala Ile Gln Thr Val Ala Asp Gly Leu Lys Lys 
            100                 105                 110         


Gln Glu Glu Glu Glu Met Asp Phe Arg Ser Gly Ser Pro Ser Asp Asn 
        115                 120                 125             


Ser Gly Ala Glu Glu Met Glu Val Ser Leu Ala Lys Pro Lys His Arg 
    130                 135                 140                 


Val Thr Met Asn Glu Phe Glu Tyr Leu Lys Leu Leu Gly Lys Gly Thr 
145                 150                 155                 160 


Phe Gly Lys Val Ile Leu Val Lys Glu Lys Ala Thr Gly Arg Tyr Tyr 
                165                 170                 175     


Ala Met Lys Ile Leu Lys Lys Glu Val Ile Val Ala Lys Asp Glu Val 
            180                 185                 190         


Ala His Thr Leu Thr Glu Asn Arg Val Leu Gln Asn Ser Arg His Pro 
        195                 200                 205             


Phe Leu Thr Ala Leu Lys Tyr Ser Phe Gln Thr His Asp Arg Leu Cys 
    210                 215                 220                 


Phe Val Met Glu Tyr Ala Asn Gly Gly Glu Leu Phe Phe His Leu Ser 
225                 230                 235                 240 


Arg Glu Arg Val Phe Ser Glu Asp Arg Ala Arg Phe Tyr Gly Ala Glu 
                245                 250                 255     


Ile Val Ser Ala Leu Asp Tyr Leu His Ser Glu Lys Asn Val Val Tyr 
            260                 265                 270         


Arg Asp Leu Lys Leu Glu Asn Leu Met Leu Asp Lys Asp Gly His Ile 
        275                 280                 285             


Lys Ile Thr Asp Phe Gly Leu Cys Lys Glu Gly Ile Lys Asp Gly Ala 
    290                 295                 300                 


Thr Met Lys Thr Phe Cys Gly Thr Pro Glu Tyr Leu Ala Pro Glu Val 
305                 310                 315                 320 


Leu Glu Asp Asn Asp Tyr Gly Arg Ala Val Asp Trp Trp Gly Leu Gly 
                325                 330                 335     


Val Val Met Tyr Glu Met Met Cys Gly Arg Leu Pro Phe Tyr Asn Gln 
            340                 345                 350         


Asp His Glu Lys Leu Phe Glu Leu Ile Leu Met Glu Glu Ile Arg Phe 
        355                 360                 365             


Pro Arg Thr Leu Gly Pro Glu Ala Lys Ser Leu Leu Ser Gly Leu Leu 
    370                 375                 380                 


Lys Lys Asp Pro Lys Gln Arg Leu Gly Gly Gly Ser Glu Asp Ala Lys 
385                 390                 395                 400 


Glu Ile Met Gln His Arg Phe Phe Ala Gly Ile Val Trp Gln His Val 
                405                 410                 415     


Tyr Glu Lys Lys Leu Ser Pro Pro Phe Lys Pro Gln Val Thr Ser Glu 
            420                 425                 430         


Thr Asp Thr Arg Tyr Phe Asp Glu Glu Phe Thr Ala Gln Met Ile Thr 
        435                 440                 445             


Ile Thr Pro Pro Asp Gln Asp Asp Ser Met Glu Cys Val Asp Ser Glu 
    450                 455                 460                 


Arg Arg Pro His Phe Pro Gln Phe Ser Tyr Ser Ala Ser Gly Thr Ala 
465                 470                 475                 480 


