                         SEQUENCE LISTING

<110>  Pfizer Inc.
 
<120>  Osteopontin Antibodies

<130>  PC33873

<150>  61/235,542
<151>  2009-08-20

<160>  78    

<170>  PatentIn version 3.5

<210>  1
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  1

Ser Asn Tyr Val Met His 
1               5       


<210>  2
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  2

Ser Ile Phe Gly Ser Gly Ser Asp Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  3
<211>  16
<212>  PRT
<213>  Homo sapiens

<400>  3

Arg Ser Ala Ser Ser Gly Phe Gly Phe Ala Gly Tyr Gly Ile Asp Ser 
1               5                   10                  15      


<210>  4
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  4

Ser Gly Asp Ser Leu Arg Tyr Tyr Tyr Ala His 
1               5                   10      


<210>  5
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  5

Asp Asp Asn Lys Arg Pro Ser 
1               5           


<210>  6
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  6

Gln Ser Trp Asp Leu Phe His Ser Ser Val 
1               5                   10  


<210>  7
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  7

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Phe Gly Ser Gly Ser Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ala Ser Ser Gly Phe Gly Phe Ala Gly Tyr Gly Ile Asp 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  8
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  8

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Tyr Tyr Tyr Ala 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Trp Asp Leu Phe His Ser Ser 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  9
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  9
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg       60

agctgcgcgg cctccggatt taccttttct aattatgtta tgcattgggt gcgccaagcc      120

cctgggaagg gtctcgagtg ggtgagctct atctttggtt ctggtagcga tacctattat      180

gcggatagcg tgaaaggccg ttttaccatt tcacgtgata attcgaaaaa caccctgtat      240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcggtctgct      300

tcttctggtt ttggttttgc tggttatggt attgattctt ggggccaagg caccctggtg      360

acggttagct ca                                                          372


<210>  10
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  10
gatatcgaac tgacccagcc gccttcagtg agcgttgcac caggtcagac cgcgcgtatc       60

tcgtgtagcg gcgattctct tcgttattat tatgctcatt ggtaccagca gaaacccggg      120

caggcgccag ttcttgtgat ttatgatgat aataagcgtc cctcaggcat cccggaacgc      180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac tcaggcggaa      240

gacgaagcgg attattattg ccagtcttgg gatctttttc attcttctgt gtttggcggc      300

ggcacgaagt taaccgtcct a                                                321


<210>  11
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  11

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Phe Gly Ser Gly Ser Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ala Ser Ser Gly Phe Gly Phe Ala Gly Tyr Gly Ile Asp 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
    210                 215                 220                 


Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  12
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  12

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Tyr Tyr Tyr Ala 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Trp Asp Leu Phe His Ser Ser 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
            100                 105                 110         


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
    130                 135                 140                 


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
145                 150                 155                 160 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             


Pro Thr Glu Cys Ser 
    210             


<210>  13
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  13
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg       60

agctgcgcgg cctccggatt taccttttct aattatgtta tgcattgggt gcgccaagcc      120

cctgggaagg gtctcgagtg ggtgagctct atctttggtt ctggtagcga tacctattat      180

gcggatagcg tgaaaggccg ttttaccatt tcacgtgata attcgaaaaa caccctgtat      240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcggtctgct      300

tcttctggtt ttggttttgc tggttatggt attgattctt ggggccaagg caccctggtg      360

acggttagct cagccagcac caagggcccc agcgtgttcc ccctggcccc ctgcagcaga      420

agcaccagcg agagcacagc cgccctgggc tgcctggtga aggactactt ccccgagccc      480

gtgaccgtga gctggaacag cggagccctg accagcggcg tgcacacctt ccccgccgtg      540

ctgcagagca gcggcctgta cagcctgagc agcgtggtga ccgtgcccag cagcaacttc      600

ggcacccaga cctacacctg caacgtggac cacaagccca gcaacaccaa ggtggacaag      660

accgtggagc ggaagtgctg cgtggagtgc cccccctgcc ctgcccctcc tgtggccgga      720

ccctccgtgt tcctgttccc ccccaagccc aaggacaccc tgatgatcag ccggaccccc      780

gaggtgacct gcgtggtggt ggacgtgagc cacgaggacc ccgaggtgca gtttaattgg      840

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc cccgggagga acagttcaac      900

agcaccttcc gggtggtgtc cgtgctgacc gtggtgcacc aggactggct gaacggcaaa      960

gaatacaagt gcaaggtgtc caacaagggc ctgcctgccc ccatcgagaa aaccatcagc     1020

aagacaaagg gccagcccag ggaaccccag gtgtacaccc tgccccccag ccgggaggaa     1080

atgaccaaga accaggtgtc cctgacctgt ctggtgaagg gcttctaccc cagcgacatc     1140

gccgtggagt gggagagcaa cggccagccc gagaacaact acaagaccac cccccccatg     1200

ctggacagcg acggcagctt cttcctgtac agcaagctga cagtggacaa gagccggtgg     1260

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1320

cagaagagcc tgagcctgtc ccccggcaaa                                      1350


<210>  14
<211>  639
<212>  DNA
<213>  Homo sapiens

<400>  14
gatatcgaac tgacccagcc gccttcagtg agcgttgcac caggtcagac cgcgcgtatc       60

tcgtgtagcg gcgattctct tcgttattat tatgctcatt ggtaccagca gaaacccggg      120

caggcgccag ttcttgtgat ttatgatgat aataagcgtc cctcaggcat cccggaacgc      180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac tcaggcggaa      240

gacgaagcgg attattattg ccagtcttgg gatctttttc attcttctgt gtttggcggc      300

ggcacgaagt taaccgtcct aggtcagccc aaggctgccc cctcggtcac tctgttcccg      360

ccctcctctg aggagcttca agccaacaag gccacactgg tgtgtctcat aagtgacttc      420

tacccgggag ccgtgacagt ggcctggaag gcagatagca gccccgtcaa ggcgggagtg      480

gagaccacca caccctccaa acaaagcaac aacaagtacg cggccagcag ctatctgagc      540

ctgacgcctg agcagtggaa gtcccacaga agctacagct gccaggtcac gcatgaaggg      600

agcaccgtgg agaagacagt ggcccctaca gaatgttca                             639


<210>  15
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  15

Asn Asn Tyr Ala Val Ser 
1               5       


<210>  16
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  16

Gly Ile Ser Tyr Gly Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  17
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  17

Arg Thr Leu Gly Gly Asp Phe Asp His 
1               5                   


<210>  18
<211>  13
<212>  PRT
<213>  Homo sapiens

<400>  18

Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn Tyr Val Asn 
1               5                   10              


<210>  19
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  19

Gly Asn Ser Lys Arg Pro Ser 
1               5           


<210>  20
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  20

Gln Ser Phe Thr Gln Met Leu Leu Val 
1               5                   


<210>  21
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  21

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Tyr Gly Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Leu Gly Gly Asp Phe Asp His Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  22
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  22

Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Phe Thr Gln Met Leu 
                85                  90                  95      


Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  23
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  23
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg       60

agctgcgcgg cctccggatt tacctttaat aattatgctg tttcttgggt gcgccaagcc      120

cctgggaagg gtctcgagtg ggtgagcggt atctcttatg gtggtagcaa tacctattat      180

gcggatagcg tgaaaggccg ttttaccatt tcacgtgata attcgaaaaa caccctgtat      240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtactctt      300

ggtggtgatt ttgatcattg gggccaaggc accctggtga cggttagctc a               351


<210>  24
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  24
gatatcgtgc tgacccagcc gccttcagtg agtggcgcac caggtcagcg tgtgaccatc       60

tcgtgtagcg gcagcagcag caacattggt tctaattatg tgaattggta ccagcagttg      120

cccgggacgg cgccgaaact tctgatttat ggtaattcta agcgtccctc aggcgtgccg      180

gatcgtttta gcggatccaa aagcggcacc agcgcgagcc ttgcgattac gggcctgcaa      240

agcgaagacg aagcggatta ttattgccag tcttttactc agatgcttct tgtgtttggc      300

ggcggcacga agttaaccgt ccta                                             324


<210>  25
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  25

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Tyr Gly Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Leu Gly Gly Asp Phe Asp His Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn 
            180                 185                 190         


Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             


<210>  26
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  26

Asp Ile Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ser Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Phe Thr Gln Met Leu 
                85                  90                  95      


Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  27
<211>  1329
<212>  DNA
<213>  Homo sapiens

<400>  27
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg       60

agctgcgcgg cctccggatt tacctttaat aattatgctg tttcttgggt gcgccaagcc      120

cctgggaagg gtctcgagtg ggtgagcggt atctcttatg gtggtagcaa tacctattat      180

gcggatagcg tgaaaggccg ttttaccatt tcacgtgata attcgaaaaa caccctgtat      240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtactctt      300

ggtggtgatt ttgatcattg gggccaaggc accctggtga cggttagctc agccagcacc      360

aagggcccca gcgtgttccc cctggccccc tgcagcagaa gcaccagcga gagcacagcc      420

gccctgggct gcctggtgaa ggactacttc cccgagcccg tgaccgtgag ctggaacagc      480

ggagccctga ccagcggcgt gcacaccttc cccgccgtgc tgcagagcag cggcctgtac      540

agcctgagca gcgtggtgac cgtgcccagc agcaacttcg gcacccagac ctacacctgc      600

aacgtggacc acaagcccag caacaccaag gtggacaaga ccgtggagcg gaagtgctgc      660

gtggagtgcc ccccctgccc tgcccctcct gtggccggac cctccgtgtt cctgttcccc      720

cccaagccca aggacaccct gatgatcagc cggacccccg aggtgacctg cgtggtggtg      780

gacgtgagcc acgaggaccc cgaggtgcag tttaattggt acgtggacgg cgtggaggtg      840

cacaacgcca agaccaagcc ccgggaggaa cagttcaaca gcaccttccg ggtggtgtcc      900

gtgctgaccg tggtgcacca ggactggctg aacggcaaag aatacaagtg caaggtgtcc      960

aacaagggcc tgcctgcccc catcgagaaa accatcagca agacaaaggg ccagcccagg     1020

gaaccccagg tgtacaccct gccccccagc cgggaggaaa tgaccaagaa ccaggtgtcc     1080

ctgacctgtc tggtgaaggg cttctacccc agcgacatcg ccgtggagtg ggagagcaac     1140

ggccagcccg agaacaacta caagaccacc ccccccatgc tggacagcga cggcagcttc     1200

ttcctgtaca gcaagctgac agtggacaag agccggtggc agcagggcaa cgtgttcagc     1260

tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagagcct gagcctgtcc     1320

cccggcaaa                                                             1329


<210>  28
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  28
gatatcgtgc tgacccagcc gccttcagtg agtggcgcac caggtcagcg tgtgaccatc       60

tcgtgtagcg gcagcagcag caacattggt tctaattatg tgaattggta ccagcagttg      120

cccgggacgg cgccgaaact tctgatttat ggtaattcta agcgtccctc aggcgtgccg      180

gatcgtttta gcggatccaa aagcggcacc agcgcgagcc ttgcgattac gggcctgcaa      240

agcgaagacg aagcggatta ttattgccag tcttttactc agatgcttct tgtgtttggc      300

ggcggcacga agttaaccgt cctaggtcag cccaaggctg ccccctcggt cactctgttc      360

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      420

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      480

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      540

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      600

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         642


<210>  29
<211>  6
<212>  PRT
<213>  Homo sapiens

<400>  29

Thr Thr Ser Ser Met His 
1               5       


<210>  30
<211>  17
<212>  PRT
<213>  Homo sapiens

<400>  30

Arg Ile Ser Ser His Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val Lys 
1               5                   10                  15      


Gly 
    


<210>  31
<211>  12
<212>  PRT
<213>  Homo sapiens

<400>  31

Arg Asp Met Tyr Arg Gly Val Tyr Gly Phe Ala Leu 
1               5                   10          


<210>  32
<211>  11
<212>  PRT
<213>  Homo sapiens

<400>  32

Ser Gly Asp Ala Ile Arg Asn Tyr Tyr Val His 
1               5                   10      


<210>  33
<211>  7
<212>  PRT
<213>  Homo sapiens

<400>  33

Glu Asp Ser Asp Arg Pro Ser 
1               5           


<210>  34
<211>  9
<212>  PRT
<213>  Homo sapiens

<400>  34

Gln Ser Tyr Asp Lys Ser Asn Val Val 
1               5                   


<210>  35
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  35

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Thr Ser 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Ser Ser His Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Met Tyr Arg Gly Val Tyr Gly Phe Ala Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  36
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  36

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ala Ile Arg Asn Tyr Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Lys Ser Asn Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  37
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  37
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg       60

agctgcgcgg cctccggatt tacctttact acttcttcta tgcattgggt gcgccaagcc      120

cctgggaagg gtctcgagtg ggtgagccgt atctcttctc atggtagcaa tacctattat      180

gcggatagcg tgaaaggccg ttttaccatt tcacgtgata attcgaaaaa caccctgtat      240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtgatatg      300

tatcgtggtg tttatggttt tgctctttgg ggccaaggca ccctggtgac ggttagctca      360


<210>  38
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  38
gatatcgaac tgacccagcc gccttcagtg agcgttgcac caggtcagac cgcgcgtatc       60

tcgtgtagcg gcgatgctat tcgtaattat tatgttcatt ggtaccagca gaaacccggg      120

caggcgccag ttcttgtgat ttatgaggat tctgatcgtc cctcaggcat cccggaacgc      180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac tcaggcggaa      240

gacgaagcgg attattattg ccagtcttat gataagtcta atgttgtgtt tggcggcggc      300

acgaagttaa ccgtccta                                                    318


<210>  39
<211>  446
<212>  PRT
<213>  Homo sapiens

<400>  39

Gln Val Gln Leu Val Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Thr Ser 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Ser Ser His Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Met Tyr Arg Gly Val Tyr Gly Phe Ala Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val 
    210                 215                 220                 


Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  40
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  40

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ala Ile Arg Asn Tyr Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Lys Ser Asn Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
            100                 105                 110         


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
        115                 120                 125             


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
    130                 135                 140                 


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
145                 150                 155                 160 


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
                165                 170                 175     


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
            180                 185                 190         


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
        195                 200                 205             


Thr Glu Cys Ser 
    210         


<210>  41
<211>  1338
<212>  DNA
<213>  Homo sapiens

<400>  41
caggtgcaat tggtggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg       60

agctgcgcgg cctccggatt tacctttact acttcttcta tgcattgggt gcgccaagcc      120

cctgggaagg gtctcgagtg ggtgagccgt atctcttctc atggtagcaa tacctattat      180

gcggatagcg tgaaaggccg ttttaccatt tcacgtgata attcgaaaaa caccctgtat      240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtgatatg      300

tatcgtggtg tttatggttt tgctctttgg ggccaaggca ccctggtgac ggttagctca      360

gccagcacca agggccccag cgtgttcccc ctggccccct gcagcagaag caccagcgag      420

agcacagccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgagc      480

tggaacagcg gagccctgac cagcggcgtg cacaccttcc ccgccgtgct gcagagcagc      540

ggcctgtaca gcctgagcag cgtggtgacc gtgcccagca gcaacttcgg cacccagacc      600

tacacctgca acgtggacca caagcccagc aacaccaagg tggacaagac cgtggagcgg      660

aagtgctgcg tggagtgccc cccctgccct gcccctcctg tggccggacc ctccgtgttc      720

ctgttccccc ccaagcccaa ggacaccctg atgatcagcc ggacccccga ggtgacctgc      780

gtggtggtgg acgtgagcca cgaggacccc gaggtgcagt ttaattggta cgtggacggc      840

gtggaggtgc acaacgccaa gaccaagccc cgggaggaac agttcaacag caccttccgg      900

gtggtgtccg tgctgaccgt ggtgcaccag gactggctga acggcaaaga atacaagtgc      960

aaggtgtcca acaagggcct gcctgccccc atcgagaaaa ccatcagcaa gacaaagggc     1020

cagcccaggg aaccccaggt gtacaccctg ccccccagcc gggaggaaat gaccaagaac     1080

caggtgtccc tgacctgtct ggtgaagggc ttctacccca gcgacatcgc cgtggagtgg     1140

gagagcaacg gccagcccga gaacaactac aagaccaccc cccccatgct ggacagcgac     1200

ggcagcttct tcctgtacag caagctgaca gtggacaaga gccggtggca gcagggcaac     1260

gtgttcagct gcagcgtgat gcacgaggcc ctgcacaacc actacaccca gaagagcctg     1320

agcctgtccc ccggcaaa                                                   1338


<210>  42
<211>  636
<212>  DNA
<213>  Homo sapiens

<400>  42
gatatcgaac tgacccagcc gccttcagtg agcgttgcac caggtcagac cgcgcgtatc       60

tcgtgtagcg gcgatgctat tcgtaattat tatgttcatt ggtaccagca gaaacccggg      120

caggcgccag ttcttgtgat ttatgaggat tctgatcgtc cctcaggcat cccggaacgc      180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac tcaggcggaa      240

gacgaagcgg attattattg ccagtcttat gataagtcta atgttgtgtt tggcggcggc      300

acgaagttaa ccgtcctagg tcagcccaag gctgccccct cggtcactct gttcccgccc      360

tcctctgagg agcttcaagc caacaaggcc acactggtgt gtctcataag tgacttctac      420

ccgggagccg tgacagtggc ctggaaggca gatagcagcc ccgtcaaggc gggagtggag      480

accaccacac cctccaaaca aagcaacaac aagtacgcgg ccagcagcta tctgagcctg      540

acgcctgagc agtggaagtc ccacagaagc tacagctgcc aggtcacgca tgaagggagc      600

accgtggaga agacagtggc ccctacagaa tgttca                                636


<210>  43
<211>  300
<212>  PRT
<213>  Homo sapiens

<400>  43

Met Arg Ile Ala Val Ile Cys Phe Cys Leu Leu Gly Ile Thr Cys Ala 
1               5                   10                  15      


Ile Pro Val Lys Gln Ala Asp Ser Gly Ser Ser Glu Glu Lys Gln Leu 
            20                  25                  30          


Tyr Asn Lys Tyr Pro Asp Ala Val Ala Thr Trp Leu Asn Pro Asp Pro 
        35                  40                  45              


Ser Gln Lys Gln Asn Leu Leu Ala Pro Gln Thr Leu Pro Ser Lys Ser 
    50                  55                  60                  


Asn Glu Ser His Asp His Met Asp Asp Met Asp Asp Glu Asp Asp Asp 
65                  70                  75                  80  


Asp His Val Asp Ser Gln Asp Ser Ile Asp Ser Asn Asp Ser Asp Asp 
                85                  90                  95      


Val Asp Asp Thr Asp Asp Ser His Gln Ser Asp Glu Ser His His Ser 
            100                 105                 110         


Asp Glu Ser Asp Glu Leu Val Thr Asp Phe Pro Thr Asp Leu Pro Ala 
        115                 120                 125             


Thr Glu Val Phe Thr Pro Val Val Pro Thr Val Asp Thr Tyr Asp Gly 
    130                 135                 140                 


Arg Gly Asp Ser Val Val Tyr Gly Leu Arg Ser Lys Ser Lys Lys Phe 
145                 150                 155                 160 


Arg Arg Pro Asp Ile Gln Tyr Pro Asp Ala Thr Asp Glu Asp Ile Thr 
                165                 170                 175     


Ser His Met Glu Ser Glu Glu Leu Asn Gly Ala Tyr Lys Ala Ile Pro 
            180                 185                 190         


Val Ala Gln Asp Leu Asn Ala Pro Ser Asp Trp Asp Ser Arg Gly Lys 
        195                 200                 205             


Asp Ser Tyr Glu Thr Ser Gln Leu Asp Asp Gln Ser Ala Glu Thr His 
    210                 215                 220                 


Ser His Lys Gln Ser Arg Leu Tyr Lys Arg Lys Ala Asn Asp Glu Ser 
225                 230                 235                 240 


Asn Glu His Ser Asp Val Ile Asp Ser Gln Glu Leu Ser Lys Val Ser 
                245                 250                 255     


Arg Glu Phe His Ser His Glu Phe His Ser His Glu Asp Met Leu Val 
            260                 265                 270         


Val Asp Pro Lys Ser Lys Glu Glu Asp Lys His Leu Lys Phe Arg Ile 
        275                 280                 285             


Ser His Glu Leu Asp Ser Ala Ser Ser Glu Val Asn 
    290                 295                 300 


<210>  44
<211>  124
<212>  PRT
<213>  Homo sapiens

<400>  44

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Phe Gly Ser Gly Ser Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ala Ser Ser Gly Phe Gly Phe Ala Gly Tyr Gly Ile Asp 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser 
        115                 120                 


<210>  45
<211>  372
<212>  DNA
<213>  Homo sapiens

<400>  45
gaggtgcagc tgctggagag cggcggcggc ctggtgcagc ccggcggcag cctgaggctg       60

tcctgcgccg ccagcggctt caccttcagc aactacgtga tgcactgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtgagcagc atcttcggca gcggcagcga cacctactac      180

gccgacagcg tgaagggcag gttcaccatc agcagggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag ggccgaggac accgccgtgt actactgcgc caggagcgcc      300

agcagcggct tcggcttcgc cggctacggc atcgacagct ggggccaggg caccctggtg      360

accgtgagct ca                                                          372


<210>  46
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  46

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Ser Leu Arg Tyr Tyr Tyr Ala 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Trp Asp Leu Phe His Ser Ser 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  47
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  47
agctacgagc tgacccagcc ccccagcgtg agcgtgagcc ccggccagac cgccagcatc       60

acctgcagcg gcgacagcct gaggtactac tacgcccact ggtaccagca gaagcccggc      120

cagagccccg tgctggtgat ctacgacgac aacaagaggc ccagcggcat ccccgagagg      180

ttcagcggca gcaacagcgg caacaccgcc accctgacca tcagcggcac ccaggccatg      240

gacgaggccg actactactg ccagagctgg gacctgttcc acagcagcgt gttcggcggc      300

ggcaccaagt taaccgtcct a                                                321


<210>  48
<211>  117
<212>  PRT
<213>  Homo sapiens

<400>  48

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Tyr Gly Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Leu Gly Gly Asp Phe Asp His Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser 
        115         


<210>  49
<211>  351
<212>  DNA
<213>  Homo sapiens

<400>  49
gaggtgcaat tgctggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg       60

agctgcgcgg cctccggatt tacctttaat aattatgctg tttcttgggt gcgccaagcc      120

cctgggaagg gtctcgagtg ggtgagcggt atctcttatg gtggtagcaa tacctattat      180

gcggatagcg tgaaaggccg ttttaccatt tcacgtgata attcgaaaaa caccctgtat      240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtactctt      300

ggtggtgatt ttgatcattg gggccaaggc accctggtga cggttagctc a               351


<210>  50
<211>  108
<212>  PRT
<213>  Homo sapiens

<400>  50

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Phe Thr Gln Met Leu 
                85                  90                  95      


Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105             


<210>  51
<211>  324
<212>  DNA
<213>  Homo sapiens

<400>  51
cagagcgtgc tgacccagcc gccttcagtg agtggcgcac caggtcagcg tgtgaccatc       60

tcgtgtagcg gcagcagcag caacattggt tctaattatg tgaattggta ccagcagttg      120

cccgggacgg cgccgaaact tctgatttat ggtaattcta agcgtccctc aggcgtgccg      180

gatcgtttta gcggatccaa aagcggcacc agcgcgagcc ttgcgattac gggcctgcaa      240

gccgaagacg aagcggatta ttattgccag tcttttactc agatgcttct tgtgtttggc      300

ggcggcacga agttaaccgt ccta                                             324


<210>  52
<211>  120
<212>  PRT
<213>  Homo sapiens

<400>  52

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Thr Ser 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Ser Ser His Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Met Tyr Arg Gly Val Tyr Gly Phe Ala Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser 
        115                 120 


<210>  53
<211>  360
<212>  DNA
<213>  Homo sapiens

<400>  53
gaggtgcaat tgctggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg       60

agctgcgcgg cctccggatt tacctttact acttcttcta tgcattgggt gcgccaagcc      120

cctgggaagg gtctcgagtg ggtgagccgt atctcttctc atggtagcaa tacctattat      180

gcggatagcg tgaaaggccg ttttaccatt tcacgtgata attcgaaaaa caccctgtat      240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtgatatg      300

tatcgtggtg tttatggttt tgctctttgg ggccaaggca ccctggtgac ggttagctca      360


<210>  54
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  54

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Ala Ile Arg Asn Tyr Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Lys Ser Asn Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  55
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  55
agctacgaac tgacccagcc gccttcagtg agcgttagcc caggtcagac cgcgagcatc       60

acctgtagcg gcgatgctat tcgtaattat tatgttcatt ggtaccagca gaaacccggg      120

cagagcccag ttcttgtgat ttatgaggat tctgatcgtc cctcaggcat cccggaacgc      180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac tcaggcgatg      240

gacgaagcgg attattattg ccagtcttat gataagtcta atgttgtgtt tggcggcggc      300

acgaagttaa ccgtccta                                                    318


<210>  56
<211>  106
<212>  PRT
<213>  Homo sapiens

<400>  56

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Ala Ile Arg Asn Tyr Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Lys Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Lys Ser Asn Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105     


<210>  57
<211>  318
<212>  DNA
<213>  Homo sapiens

<400>  57
agctacgagc tgacccagcc ccctagcgtg tccgtgagcc ctggccagac cgccagcatc       60

acatgcagcg gcgacgccat ccggaactac tatgtgcatt ggtatcagca gaagcccggc      120

cagagcccca agctggtcat ctacgaggac agcgacagac ccagcggcat ccccgagaga      180

ttcagcggca gcaacagcgg caataccgcc accctgacca tcagcggcac ccaggccatg      240

gacgaggccg actactactg ccagagctac gacaagagca acgtggtgtt cggcggaggg      300

accaagctga ccgtccta                                                    318


<210>  58
<211>  450
<212>  PRT
<213>  Homo sapiens

<400>  58

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Asn Tyr 
            20                  25                  30          


Val Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Ser Ile Phe Gly Ser Gly Ser Asp Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Ser Ala Ser Ser Gly Phe Gly Phe Ala Gly Tyr Gly Ile Asp 
            100                 105                 110         


Ser Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys 
        115                 120                 125             


Gly Pro Ser Val Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu 
    130                 135                 140                 


Ser Thr Ala Ala Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro 
145                 150                 155                 160 


Val Thr Val Ser Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr 
                165                 170                 175     


Phe Pro Ala Val Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val 
            180                 185                 190         


Val Thr Val Pro Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn 
        195                 200                 205             


Val Asp His Lys Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg 
    210                 215                 220                 


Lys Cys Cys Val Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly 
225                 230                 235                 240 


Pro Ser Val Phe Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile 
                245                 250                 255     


Ser Arg Thr Pro Glu Val Thr Cys Val Val Val Asp Val Ser His Glu 
            260                 265                 270         


Asp Pro Glu Val Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His 
        275                 280                 285             


Asn Ala Lys Thr Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg 
    290                 295                 300                 


Val Val Ser Val Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys 
305                 310                 315                 320 


Glu Tyr Lys Cys Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu 
                325                 330                 335     


Lys Thr Ile Ser Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr 
            340                 345                 350         


Thr Leu Pro Pro Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu 
        355                 360                 365             


Thr Cys Leu Val Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp 
    370                 375                 380                 


Glu Ser Asn Gly Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met 
385                 390                 395                 400 


Leu Asp Ser Asp Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp 
                405                 410                 415     


Lys Ser Arg Trp Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His 
            420                 425                 430         


Glu Ala Leu His Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro 
        435                 440                 445             


Gly Lys 
    450 


<210>  59
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  59

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Ser Leu Arg Tyr Tyr Tyr Ala 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Trp Asp Leu Phe His Ser Ser 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
            100                 105                 110         


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
    130                 135                 140                 


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
145                 150                 155                 160 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             


Pro Thr Glu Cys Ser 
    210             


<210>  60
<211>  1350
<212>  DNA
<213>  Homo sapiens

<400>  60
gaggtgcagc tgctggagag cggcggcggc ctggtgcagc ccggcggcag cctgaggctg       60

tcctgcgccg ccagcggctt caccttcagc aactacgtga tgcactgggt gaggcaggcc      120

cccggcaagg gcctggagtg ggtgagcagc atcttcggca gcggcagcga cacctactac      180

gccgacagcg tgaagggcag gttcaccatc agcagggaca acagcaagaa caccctgtac      240

ctgcagatga acagcctgag ggccgaggac accgccgtgt actactgcgc caggagcgcc      300

agcagcggct tcggcttcgc cggctacggc atcgacagct ggggccaggg caccctggtg      360

accgtgagct cagccagcac caagggcccc agcgtgttcc ccctggcccc ctgcagcaga      420

agcaccagcg agagcacagc cgccctgggc tgcctggtga aggactactt ccccgagccc      480

gtgaccgtga gctggaacag cggagccctg accagcggcg tgcacacctt ccccgccgtg      540

ctgcagagca gcggcctgta cagcctgagc agcgtggtga ccgtgcccag cagcaacttc      600

ggcacccaga cctacacctg caacgtggac cacaagccca gcaacaccaa ggtggacaag      660

accgtggagc ggaagtgctg cgtggagtgc cccccctgcc ctgcccctcc tgtggccgga      720

ccctccgtgt tcctgttccc ccccaagccc aaggacaccc tgatgatcag ccggaccccc      780

gaggtgacct gcgtggtggt ggacgtgagc cacgaggacc ccgaggtgca gtttaattgg      840

tacgtggacg gcgtggaggt gcacaacgcc aagaccaagc cccgggagga acagttcaac      900

agcaccttcc gggtggtgtc cgtgctgacc gtggtgcacc aggactggct gaacggcaaa      960

gaatacaagt gcaaggtgtc caacaagggc ctgcctgccc ccatcgagaa aaccatcagc     1020

aagacaaagg gccagcccag ggaaccccag gtgtacaccc tgccccccag ccgggaggaa     1080

atgaccaaga accaggtgtc cctgacctgt ctggtgaagg gcttctaccc cagcgacatc     1140

gccgtggagt gggagagcaa cggccagccc gagaacaact acaagaccac cccccccatg     1200

ctggacagcg acggcagctt cttcctgtac agcaagctga cagtggacaa gagccggtgg     1260

cagcagggca acgtgttcag ctgcagcgtg atgcacgagg ccctgcacaa ccactacacc     1320

cagaagagcc tgagcctgtc ccccggcaaa                                      1350


<210>  61
<211>  639
<212>  DNA
<213>  Homo sapiens

<400>  61
agctacgagc tgacccagcc ccccagcgtg agcgtgagcc ccggccagac cgccagcatc       60

acctgcagcg gcgacagcct gaggtactac tacgcccact ggtaccagca gaagcccggc      120

cagagccccg tgctggtgat ctacgacgac aacaagaggc ccagcggcat ccccgagagg      180

ttcagcggca gcaacagcgg caacaccgcc accctgacca tcagcggcac ccaggccatg      240

gacgaggccg actactactg ccagagctgg gacctgttcc acagcagcgt gttcggcggc      300

ggcaccaagt taaccgtcct aggtcagccc aaggctgccc cctcggtcac tctgttcccg      360

ccctcctctg aggagcttca agccaacaag gccacactgg tgtgtctcat aagtgacttc      420

tacccgggag ccgtgacagt ggcctggaag gcagatagca gccccgtcaa ggcgggagtg      480

gagaccacca caccctccaa acaaagcaac aacaagtacg cggccagcag ctatctgagc      540

ctgacgcctg agcagtggaa gtcccacaga agctacagct gccaggtcac gcatgaaggg      600

agcaccgtgg agaagacagt ggcccctaca gaatgttca                             639


<210>  62
<211>  443
<212>  PRT
<213>  Homo sapiens

<400>  62

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Asn Asn Tyr 
            20                  25                  30          


Ala Val Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Gly Ile Ser Tyr Gly Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Thr Leu Gly Gly Asp Phe Asp His Trp Gly Gln Gly Thr Leu 
            100                 105                 110         


Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val Phe Pro Leu 
        115                 120                 125             


Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala Leu Gly Cys 
    130                 135                 140                 


Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser Trp Asn Ser 
145                 150                 155                 160 


Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val Leu Gln Ser 
                165                 170                 175     


Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro Ser Ser Asn 
            180                 185                 190         


Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys Pro Ser Asn 
        195                 200                 205             


Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val Glu Cys Pro 
    210                 215                 220                 


Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe Leu Phe Pro 
225                 230                 235                 240 


Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro Glu Val Thr 
                245                 250                 255     


Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val Gln Phe Asn 
            260                 265                 270         


Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr Lys Pro Arg 
        275                 280                 285             


Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val Leu Thr Val 
    290                 295                 300                 


Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys Lys Val Ser 
305                 310                 315                 320 


Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser Lys Thr Lys 
                325                 330                 335     


Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro Ser Arg Glu 
            340                 345                 350         


Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val Lys Gly Phe 
        355                 360                 365             


Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly Gln Pro Glu 
    370                 375                 380                 


Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp Gly Ser Phe 
385                 390                 395                 400 


Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp Gln Gln Gly 
                405                 410                 415     


Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His Asn His Tyr 
            420                 425                 430         


Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440             


<210>  63
<211>  214
<212>  PRT
<213>  Homo sapiens

<400>  63

Gln Ser Val Leu Thr Gln Pro Pro Ser Val Ser Gly Ala Pro Gly Gln 
1               5                   10                  15      


Arg Val Thr Ile Ser Cys Ser Gly Ser Ser Ser Asn Ile Gly Ser Asn 
            20                  25                  30          


Tyr Val Asn Trp Tyr Gln Gln Leu Pro Gly Thr Ala Pro Lys Leu Leu 
        35                  40                  45              


Ile Tyr Gly Asn Ser Lys Arg Pro Ser Gly Val Pro Asp Arg Phe Ser 
    50                  55                  60                  


Gly Ser Lys Ser Gly Thr Ser Ala Ser Leu Ala Ile Thr Gly Leu Gln 
65                  70                  75                  80  


Ala Glu Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Phe Thr Gln Met Leu 
                85                  90                  95      


Leu Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys 
            100                 105                 110         


Ala Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln 
        115                 120                 125             


Ala Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly 
    130                 135                 140                 


Ala Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly 
145                 150                 155                 160 


Val Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala 
                165                 170                 175     


Ser Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser 
            180                 185                 190         


Tyr Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val 
        195                 200                 205             


Ala Pro Thr Glu Cys Ser 
    210                 


<210>  64
<211>  1329
<212>  DNA
<213>  Homo sapiens

<400>  64
gaggtgcaat tgctggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg       60

agctgcgcgg cctccggatt tacctttaat aattatgctg tttcttgggt gcgccaagcc      120

cctgggaagg gtctcgagtg ggtgagcggt atctcttatg gtggtagcaa tacctattat      180

gcggatagcg tgaaaggccg ttttaccatt tcacgtgata attcgaaaaa caccctgtat      240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtactctt      300

ggtggtgatt ttgatcattg gggccaaggc accctggtga cggttagctc agccagcacc      360

aagggcccca gcgtgttccc cctggccccc tgcagcagaa gcaccagcga gagcacagcc      420

gccctgggct gcctggtgaa ggactacttc cccgagcccg tgaccgtgag ctggaacagc      480

ggagccctga ccagcggcgt gcacaccttc cccgccgtgc tgcagagcag cggcctgtac      540

agcctgagca gcgtggtgac cgtgcccagc agcaacttcg gcacccagac ctacacctgc      600

aacgtggacc acaagcccag caacaccaag gtggacaaga ccgtggagcg gaagtgctgc      660

gtggagtgcc ccccctgccc tgcccctcct gtggccggac cctccgtgtt cctgttcccc      720

cccaagccca aggacaccct gatgatcagc cggacccccg aggtgacctg cgtggtggtg      780

gacgtgagcc acgaggaccc cgaggtgcag tttaattggt acgtggacgg cgtggaggtg      840

cacaacgcca agaccaagcc ccgggaggaa cagttcaaca gcaccttccg ggtggtgtcc      900

gtgctgaccg tggtgcacca ggactggctg aacggcaaag aatacaagtg caaggtgtcc      960

aacaagggcc tgcctgcccc catcgagaaa accatcagca agacaaaggg ccagcccagg     1020

gaaccccagg tgtacaccct gccccccagc cgggaggaaa tgaccaagaa ccaggtgtcc     1080

ctgacctgtc tggtgaaggg cttctacccc agcgacatcg ccgtggagtg ggagagcaac     1140

ggccagcccg agaacaacta caagaccacc ccccccatgc tggacagcga cggcagcttc     1200

ttcctgtaca gcaagctgac agtggacaag agccggtggc agcagggcaa cgtgttcagc     1260

tgcagcgtga tgcacgaggc cctgcacaac cactacaccc agaagagcct gagcctgtcc     1320

cccggcaaa                                                             1329


<210>  65
<211>  642
<212>  DNA
<213>  Homo sapiens

<400>  65
cagagcgtgc tgacccagcc gccttcagtg agtggcgcac caggtcagcg tgtgaccatc       60

tcgtgtagcg gcagcagcag caacattggt tctaattatg tgaattggta ccagcagttg      120

cccgggacgg cgccgaaact tctgatttat ggtaattcta agcgtccctc aggcgtgccg      180

gatcgtttta gcggatccaa aagcggcacc agcgcgagcc ttgcgattac gggcctgcaa      240

gccgaagacg aagcggatta ttattgccag tcttttactc agatgcttct tgtgtttggc      300

ggcggcacga agttaaccgt cctaggtcag cccaaggctg ccccctcggt cactctgttc      360

ccgccctcct ctgaggagct tcaagccaac aaggccacac tggtgtgtct cataagtgac      420

ttctacccgg gagccgtgac agtggcctgg aaggcagata gcagccccgt caaggcggga      480

gtggagacca ccacaccctc caaacaaagc aacaacaagt acgcggccag cagctatctg      540

agcctgacgc ctgagcagtg gaagtcccac agaagctaca gctgccaggt cacgcatgaa      600

gggagcaccg tggagaagac agtggcccct acagaatgtt ca                         642


<210>  66
<211>  446
<212>  PRT
<213>  Homo sapiens

<400>  66

Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 
1               5                   10                  15      


Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Thr Thr Ser 
            20                  25                  30          


Ser Met His Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 
        35                  40                  45              


Ser Arg Ile Ser Ser His Gly Ser Asn Thr Tyr Tyr Ala Asp Ser Val 
    50                  55                  60                  


Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr 
65                  70                  75                  80  


Leu Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Asp Met Tyr Arg Gly Val Tyr Gly Phe Ala Leu Trp Gly Gln 
            100                 105                 110         


Gly Thr Leu Val Thr Val Ser Ser Ala Ser Thr Lys Gly Pro Ser Val 
        115                 120                 125             


Phe Pro Leu Ala Pro Cys Ser Arg Ser Thr Ser Glu Ser Thr Ala Ala 
    130                 135                 140                 


Leu Gly Cys Leu Val Lys Asp Tyr Phe Pro Glu Pro Val Thr Val Ser 
145                 150                 155                 160 


Trp Asn Ser Gly Ala Leu Thr Ser Gly Val His Thr Phe Pro Ala Val 
                165                 170                 175     


Leu Gln Ser Ser Gly Leu Tyr Ser Leu Ser Ser Val Val Thr Val Pro 
            180                 185                 190         


Ser Ser Asn Phe Gly Thr Gln Thr Tyr Thr Cys Asn Val Asp His Lys 
        195                 200                 205             


Pro Ser Asn Thr Lys Val Asp Lys Thr Val Glu Arg Lys Cys Cys Val 
    210                 215                 220                 


Glu Cys Pro Pro Cys Pro Ala Pro Pro Val Ala Gly Pro Ser Val Phe 
225                 230                 235                 240 


Leu Phe Pro Pro Lys Pro Lys Asp Thr Leu Met Ile Ser Arg Thr Pro 
                245                 250                 255     


Glu Val Thr Cys Val Val Val Asp Val Ser His Glu Asp Pro Glu Val 
            260                 265                 270         


Gln Phe Asn Trp Tyr Val Asp Gly Val Glu Val His Asn Ala Lys Thr 
        275                 280                 285             


Lys Pro Arg Glu Glu Gln Phe Asn Ser Thr Phe Arg Val Val Ser Val 
    290                 295                 300                 


Leu Thr Val Val His Gln Asp Trp Leu Asn Gly Lys Glu Tyr Lys Cys 
305                 310                 315                 320 


Lys Val Ser Asn Lys Gly Leu Pro Ala Pro Ile Glu Lys Thr Ile Ser 
                325                 330                 335     


Lys Thr Lys Gly Gln Pro Arg Glu Pro Gln Val Tyr Thr Leu Pro Pro 
            340                 345                 350         


Ser Arg Glu Glu Met Thr Lys Asn Gln Val Ser Leu Thr Cys Leu Val 
        355                 360                 365             


Lys Gly Phe Tyr Pro Ser Asp Ile Ala Val Glu Trp Glu Ser Asn Gly 
    370                 375                 380                 


Gln Pro Glu Asn Asn Tyr Lys Thr Thr Pro Pro Met Leu Asp Ser Asp 
385                 390                 395                 400 


Gly Ser Phe Phe Leu Tyr Ser Lys Leu Thr Val Asp Lys Ser Arg Trp 
                405                 410                 415     


Gln Gln Gly Asn Val Phe Ser Cys Ser Val Met His Glu Ala Leu His 
            420                 425                 430         


Asn His Tyr Thr Gln Lys Ser Leu Ser Leu Ser Pro Gly Lys 
        435                 440                 445     


<210>  67
<211>  212
<212>  PRT
<213>  Homo sapiens

<400>  67

Ser Tyr Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ser Pro Gly Gln 
1               5                   10                  15      


Thr Ala Ser Ile Thr Cys Ser Gly Asp Ala Ile Arg Asn Tyr Tyr Val 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ser Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Glu Asp Ser Asp Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Met 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ser Tyr Asp Lys Ser Asn Val Val 
                85                  90                  95      


Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala Ala 
            100                 105                 110         


Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala Asn 
        115                 120                 125             


Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala Val 
    130                 135                 140                 


Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val Glu 
145                 150                 155                 160 


Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser Ser 
                165                 170                 175     


Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr Ser 
            180                 185                 190         


Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala Pro 
        195                 200                 205             


Thr Glu Cys Ser 
    210         


<210>  68
<211>  1338
<212>  DNA
<213>  Homo sapiens

<400>  68
gaggtgcaat tgctggaaag cggcggcggc ctggtgcaac cgggcggcag cctgcgtctg       60

agctgcgcgg cctccggatt tacctttact acttcttcta tgcattgggt gcgccaagcc      120

cctgggaagg gtctcgagtg ggtgagccgt atctcttctc atggtagcaa tacctattat      180

gcggatagcg tgaaaggccg ttttaccatt tcacgtgata attcgaaaaa caccctgtat      240

ctgcaaatga acagcctgcg tgcggaagat acggccgtgt attattgcgc gcgtgatatg      300

tatcgtggtg tttatggttt tgctctttgg ggccaaggca ccctggtgac ggttagctca      360

gccagcacca agggccccag cgtgttcccc ctggccccct gcagcagaag caccagcgag      420

agcacagccg ccctgggctg cctggtgaag gactacttcc ccgagcccgt gaccgtgagc      480

tggaacagcg gagccctgac cagcggcgtg cacaccttcc ccgccgtgct gcagagcagc      540

ggcctgtaca gcctgagcag cgtggtgacc gtgcccagca gcaacttcgg cacccagacc      600

tacacctgca acgtggacca caagcccagc aacaccaagg tggacaagac cgtggagcgg      660

aagtgctgcg tggagtgccc cccctgccct gcccctcctg tggccggacc ctccgtgttc      720

ctgttccccc ccaagcccaa ggacaccctg atgatcagcc ggacccccga ggtgacctgc      780

gtggtggtgg acgtgagcca cgaggacccc gaggtgcagt ttaattggta cgtggacggc      840

gtggaggtgc acaacgccaa gaccaagccc cgggaggaac agttcaacag caccttccgg      900

gtggtgtccg tgctgaccgt ggtgcaccag gactggctga acggcaaaga atacaagtgc      960

aaggtgtcca acaagggcct gcctgccccc atcgagaaaa ccatcagcaa gacaaagggc     1020

cagcccaggg aaccccaggt gtacaccctg ccccccagcc gggaggaaat gaccaagaac     1080

caggtgtccc tgacctgtct ggtgaagggc ttctacccca gcgacatcgc cgtggagtgg     1140

gagagcaacg gccagcccga gaacaactac aagaccaccc cccccatgct ggacagcgac     1200

ggcagcttct tcctgtacag caagctgaca gtggacaaga gccggtggca gcagggcaac     1260

gtgttcagct gcagcgtgat gcacgaggcc ctgcacaacc actacaccca gaagagcctg     1320

agcctgtccc ccggcaaa                                                   1338


<210>  69
<211>  636
<212>  DNA
<213>  Homo sapiens

<400>  69
agctacgaac tgacccagcc gccttcagtg agcgttagcc caggtcagac cgcgagcatc       60

acctgtagcg gcgatgctat tcgtaattat tatgttcatt ggtaccagca gaaacccggg      120

cagagcccag ttcttgtgat ttatgaggat tctgatcgtc cctcaggcat cccggaacgc      180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac tcaggcgatg      240

gacgaagcgg attattattg ccagtcttat gataagtcta atgttgtgtt tggcggcggc      300

acgaagttaa ccgtcctagg tcagcccaag gctgccccct cggtcactct gttcccgccc      360

tcctctgagg agcttcaagc caacaaggcc acactggtgt gtctcataag tgacttctac      420

ccgggagccg tgacagtggc ctggaaggca gatagcagcc ccgtcaaggc gggagtggag      480

accaccacac cctccaaaca aagcaacaac aagtacgcgg ccagcagcta tctgagcctg      540

acgcctgagc agtggaagtc ccacagaagc tacagctgcc aggtcacgca tgaagggagc      600

accgtggaga agacagtggc ccctacagaa tgttca                                636


<210>  70
<211>  23
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  70
cctaccgttc gtcttcaccc ctg                                               23


<210>  71
<211>  21
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  71
ggcactggct ggtttcgcta c                                                 21


<210>  72
<211>  20
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  72
ctcggagcca gcggaaacac                                                   20


<210>  73
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  73
cggaaaaata aacacgctcg ga                                                22


<210>  74
<211>  22
<212>  DNA
<213>  Artificial Sequence

<220>
<223>  Primer

<400>  74
gctcacactc ggtgcggctt tc                                                22


<210>  75
<211>  10
<212>  PRT
<213>  Homo sapiens

<400>  75

Gln Ala Trp Asp Leu Ile Asn Ser His Val 
1               5                   10  


<210>  76
<211>  107
<212>  PRT
<213>  Homo sapiens

<400>  76

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Tyr Tyr Tyr Ala 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Leu Ile Asn Ser His 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu 
            100                 105         


<210>  77
<211>  321
<212>  DNA
<213>  Homo sapiens

<400>  77
gatatcgaac tgacccagcc gccttcagtg agcgttgcac caggtcagac cgcgcgtatc       60

tcgtgtagcg gcgattctct tcgttattat tatgctcatt ggtaccagca gaaacccggg      120

caggcgccag ttcttgtgat ttatgatgat aataagcgtc cctcaggcat cccggaacgc      180

tttagcggat ccaacagcgg caacaccgcg accctgacca ttagcggcac tcaggcggaa      240

gacgaagcgg attattattg ccaggcttgg gatcttatta attctcatgt gtttggcggc      300

ggcacgaagt taaccgtcct a                                                321


<210>  78
<211>  213
<212>  PRT
<213>  Homo sapiens

<400>  78

Asp Ile Glu Leu Thr Gln Pro Pro Ser Val Ser Val Ala Pro Gly Gln 
1               5                   10                  15      


Thr Ala Arg Ile Ser Cys Ser Gly Asp Ser Leu Arg Tyr Tyr Tyr Ala 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Val Leu Val Ile Tyr 
        35                  40                  45              


Asp Asp Asn Lys Arg Pro Ser Gly Ile Pro Glu Arg Phe Ser Gly Ser 
    50                  55                  60                  


Asn Ser Gly Asn Thr Ala Thr Leu Thr Ile Ser Gly Thr Gln Ala Glu 
65                  70                  75                  80  


Asp Glu Ala Asp Tyr Tyr Cys Gln Ala Trp Asp Leu Ile Asn Ser His 
                85                  90                  95      


Val Phe Gly Gly Gly Thr Lys Leu Thr Val Leu Gly Gln Pro Lys Ala 
            100                 105                 110         


Ala Pro Ser Val Thr Leu Phe Pro Pro Ser Ser Glu Glu Leu Gln Ala 
        115                 120                 125             


Asn Lys Ala Thr Leu Val Cys Leu Ile Ser Asp Phe Tyr Pro Gly Ala 
    130                 135                 140                 


Val Thr Val Ala Trp Lys Ala Asp Ser Ser Pro Val Lys Ala Gly Val 
145                 150                 155                 160 


Glu Thr Thr Thr Pro Ser Lys Gln Ser Asn Asn Lys Tyr Ala Ala Ser 
                165                 170                 175     


Ser Tyr Leu Ser Leu Thr Pro Glu Gln Trp Lys Ser His Arg Ser Tyr 
            180                 185                 190         


Ser Cys Gln Val Thr His Glu Gly Ser Thr Val Glu Lys Thr Val Ala 
        195                 200                 205             


Pro Thr Glu Cys Ser 
    210             


