                         SEQUENCE LISTING

<110>  PIERRE FABRE MEDICAMENT
 
<120>  NOVEL ANTI-cMET ANTIBODY AND ITS USE FOR THE DETECTION AND THE 
       DIAGNOSTIC OF CANCER.

<130>  D27752

<150>  EP 09305777.6
<151>  2009-08-21

<150>  US 61/235,864
<151>  2009-08-21

<150>  US 61/348,005
<151>  2010-05-25

<160>  60    

<170>  PatentIn version 3.3

<210>  1
<211>  5
<212>  PRT
<213>  mus musculus

<400>  1

Thr Ser Ala Tyr Phe 
1               5   


<210>  2
<211>  7
<212>  PRT
<213>  mus musculus

<400>  2

Ile Asn Tyr Asp Gly Thr Asn 
1               5           


<210>  3
<211>  6
<212>  PRT
<213>  mus musculus

<400>  3

Asp Arg Thr Phe Ala Tyr 
1               5       


<210>  4
<211>  6
<212>  PRT
<213>  mus musculus

<400>  4

Gln Arg Ile Tyr Asn Tyr 
1               5       


<210>  5
<211>  3
<212>  PRT
<213>  mus musculus

<400>  5

Tyr Ala Ser 
1           


<210>  6
<211>  9
<212>  PRT
<213>  mus musculus

<400>  6

Gln Gln Ser Asn Ser Trp Pro Leu Thr 
1               5                   


<210>  7
<211>  9
<212>  PRT
<213>  mus musculus

<400>  7

Gly Tyr Ser Ile Thr Ser Ala Tyr Phe 
1               5                   


<210>  8
<211>  8
<212>  PRT
<213>  mus musculus

<400>  8

Thr Arg Asp Arg Thr Phe Ala Tyr 
1               5               


<210>  9
<211>  7
<212>  PRT
<213>  mus musculus

<400>  9

Thr Ser Ala Tyr Phe Trp Ser 
1               5           


<210>  10
<211>  16
<212>  PRT
<213>  mus musculus

<400>  10

Phe Ile Asn Tyr Asp Gly Thr Asn Asn Tyr Asn Pro Ser Leu Lys Asn 
1               5                   10                  15      


<210>  11
<211>  11
<212>  PRT
<213>  mus musculus

<400>  11

Arg Ala Ser Gln Arg Ile Tyr Asn Tyr Leu His 
1               5                   10      


<210>  12
<211>  7
<212>  PRT
<213>  mus musculus

<400>  12

Tyr Ala Ser Gln Ser Ile Ser 
1               5           


<210>  13
<211>  115
<212>  PRT
<213>  mus musculus

<400>  13

Asp Leu Gln Leu Gln Glu Ser Gly Pro Gly Leu Val Lys Pro Ser Gln 
1               5                   10                  15      


Ser Leu Ser Leu Thr Cys Ser Val Thr Gly Tyr Ser Ile Thr Ser Ala 
            20                  25                  30          


Tyr Phe Trp Ser Trp Ile Arg Gln Phe Pro Gly Asn Lys Leu Glu Trp 
        35                  40                  45              


Met Gly Phe Ile Asn Tyr Asp Gly Thr Asn Asn Tyr Asn Pro Ser Leu 
    50                  55                  60                  


Lys Asn Arg Ile Ser Ile Thr Arg Asp Thr Ser Lys Asn Gln Phe Phe 
65                  70                  75                  80  


Leu Arg Leu Asn Ser Val Thr Thr Asp Asp Thr Ala Thr Tyr Tyr Cys 
                85                  90                  95      


Thr Arg Asp Arg Thr Phe Ala Tyr Trp Gly Gln Gly Thr Leu Val Thr 
            100                 105                 110         


Val Ser Ala 
        115 


<210>  14
<211>  107
<212>  PRT
<213>  mus musculus

<400>  14

Asp Ile Val Leu Thr Gln Ser Pro Ala Thr Leu Ser Val Thr Pro Gly 
1               5                   10                  15      


Asp Arg Val Ser Leu Ser Cys Arg Ala Ser Gln Arg Ile Tyr Asn Tyr 
            20                  25                  30          


Leu His Trp Tyr Gln Gln Lys Ser His Glu Ser Pro Arg Leu Leu Ile 
        35                  40                  45              


Lys Tyr Ala Ser Gln Ser Ile Ser Gly Ile Pro Ser Arg Phe Ser Gly 
    50                  55                  60                  


Ser Gly Ser Gly Thr Asp Phe Ile Leu Thr Ile Asn Ser Val Glu Thr 
65                  70                  75                  80  


Glu Asp Phe Gly Met Tyr Phe Cys Gln Gln Ser Asn Ser Trp Pro Leu 
                85                  90                  95      


Thr Phe Gly Ala Gly Thr Lys Leu Glu Leu Arg 
            100                 105         


<210>  15
<211>  15
<212>  DNA
<213>  mus musculus

<400>  15
accagtgctt atttc                                                      15


<210>  16
<211>  21
<212>  DNA
<213>  mus musculus

<400>  16
ataaactacg acggtaccaa t                                               21


<210>  17
<211>  18
<212>  DNA
<213>  mus musculus

<400>  17
gatcggacct ttgcttat                                                   18


<210>  18
<211>  18
<212>  DNA
<213>  mus musculus

<400>  18
caaagaattt acaactac                                                   18


<210>  19
<211>  9
<212>  DNA
<213>  mus musculus

<400>  19
tatgcttcc                                                              9


<210>  20
<211>  27
<212>  DNA
<213>  mus musculus

<400>  20
caacagagta acagctggcc tctcacg                                         27


<210>  21
<211>  27
<212>  DNA
<213>  mus musculus

<400>  21
ggctactcca tcaccagtgc ttatttc                                         27


<210>  22
<211>  24
<212>  DNA
<213>  mus musculus

<400>  22
acaagagatc ggacctttgc ttat                                            24


<210>  23
<211>  21
<212>  DNA
<213>  mus musculus

<400>  23
accagtgctt atttctggag c                                               21


<210>  24
<211>  48
<212>  DNA
<213>  mus musculus

<400>  24
ttcataaact acgacggtac caataactac aacccatctc tcaaaaat                  48


<210>  25
<211>  33
<212>  DNA
<213>  mus musculus

<400>  25
agggccagtc aaagaattta caactaccta cac                                  33


<210>  26
<211>  21
<212>  DNA
<213>  mus musculus

<400>  26
tatgcttccc agtccatctc t                                               21


<210>  27
<211>  345
<212>  DNA
<213>  mus musculus

<400>  27
gatctacagc ttcaggagtc aggacctggc ctcgtgaaac cttctcagtc tctgtctctc     60

acctgctctg tcactggcta ctccatcacc agtgcttatt tctggagctg gatccggcag    120

tttccaggaa acaaactgga atggatgggc ttcataaact acgacggtac caataactac    180

aacccatctc tcaaaaatcg aatctccatc actcgtgata catctaagaa ccagtttttc    240

ctgaggttga attctgtgac tactgacgac acagctacgt attactgtac aagagatcgg    300

acctttgctt attggggcca agggactctg gtcactgtct ctgca                    345


<210>  28
<211>  321
<212>  DNA
<213>  mus musculus

<400>  28
gatattgtgt taactcagtc tccagccacc ctgtctgtga ctccaggaga tagagtcagt     60

ctttcctgca gggccagtca aagaatttac aactacctac actggtatca acaaaaatca    120

catgagtctc caaggcttct catcaagtat gcttcccagt ccatctctgg gatcccctcc    180

aggttcagtg gcagtggctc agggacagat ttcattctca ctatcaacag tgtggagact    240

gaagattttg gaatgtattt ctgtcaacag agtaacagct ggcctctcac gttcggtgct    300

gggaccaagc tggagctgag a                                              321


<210>  29
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  29

Gly Tyr Thr Phe Thr Ser Tyr Trp 
1               5               


<210>  30
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  30

Ile Asn Pro Ser Asn Gly Arg Thr 
1               5               


<210>  31
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  31

Ala Arg Arg Val Gly Tyr Leu Met Asp Tyr 
1               5                   10  


<210>  32
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  32

Ser Ser Val Ser Tyr 
1               5   


<210>  33
<211>  3
<212>  PRT
<213>  Mus musculus

<400>  33

Asp Thr Ser 
1           


<210>  34
<211>  9
<212>  PRT
<213>  Mus musculus

<400>  34

Gln Gln Trp Asn Ser Asn Pro Pro Thr 
1               5                   


<210>  35
<211>  5
<212>  PRT
<213>  Mus musculus

<400>  35

Ser Tyr Trp Met His 
1               5   


<210>  36
<211>  17
<212>  PRT
<213>  Mus musculus

<400>  36

Glu Ile Asn Pro Ser Asn Gly Arg Thr His Tyr Asn Glu Lys Phe Arg 
1               5                   10                  15      


Thr 
    


<210>  37
<211>  8
<212>  PRT
<213>  Mus musculus

<400>  37

Arg Val Gly Tyr Leu Met Asp Tyr 
1               5               


<210>  38
<211>  10
<212>  PRT
<213>  Mus musculus

<400>  38

Ser Ala Ser Ser Ser Val Ser Tyr Met His 
1               5                   10  


<210>  39
<211>  7
<212>  PRT
<213>  Mus musculus

<400>  39

Asp Thr Ser Lys Leu Ala Ser 
1               5           


<210>  40
<211>  117
<212>  PRT
<213>  Mus musculus

<400>  40

Gln Val Gln Leu Gln Gln Pro Gly Ala Glu Leu Val Lys Pro Gly Ala 
1               5                   10                  15      


Ser Val Lys Leu Ser Cys Lys Ala Ser Gly Tyr Thr Phe Thr Ser Tyr 
            20                  25                  30          


Trp Met His Trp Val Lys Gln Arg Pro Gly Gln Gly Leu Glu Trp Ile 
        35                  40                  45              


Gly Glu Ile Asn Pro Ser Asn Gly Arg Thr His Tyr Asn Glu Lys Phe 
    50                  55                  60                  


Arg Thr Lys Ala Thr Leu Thr Val Ala Lys Ser Ser Ile Thr Ala Tyr 
65                  70                  75                  80  


Met Gln Leu Ser Thr Leu Thr Ser Glu Asp Ser Ala Val Tyr Tyr Cys 
                85                  90                  95      


Ala Arg Arg Val Gly Tyr Leu Met Asp Tyr Trp Gly Gln Gly Thr Ser 
            100                 105                 110         


Val Thr Ala Pro Gln 
        115         


<210>  41
<211>  106
<212>  PRT
<213>  Mus musculus

<400>  41

Gln Ile Val Leu Thr Gln Ser Pro Ala Ile Met Ser Ala Ser Pro Gly 
1               5                   10                  15      


Glu Lys Val Thr Met Thr Cys Ser Ala Ser Ser Ser Val Ser Tyr Met 
            20                  25                  30          


His Trp Tyr Gln Gln Lys Ser Gly Thr Ser Pro Lys Arg Leu Ile Tyr 
        35                  40                  45              


Asp Thr Ser Lys Leu Ala Ser Gly Val Pro Ala Arg Phe Ser Gly Ser 
    50                  55                  60                  


Gly Ser Gly Thr Ser Tyr Ser Leu Thr Ile Ser Ser Met Glu Ala Glu 
65                  70                  75                  80  


Asp Ala Ala Thr Tyr Tyr Cys Gln Gln Trp Asn Ser Asn Pro Pro Thr 
                85                  90                  95      


Phe Gly Ala Gly Thr Lys Leu Glu Leu Lys 
            100                 105     


<210>  42
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  42
ggctacacct tcaccagcta ctgg                                            24


<210>  43
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  43
attaatccta gcaacggtcg tact                                            24


<210>  44
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  44
gcaagaaggg ttggttacct catggactac                                      30


<210>  45
<211>  15
<212>  DNA
<213>  Mus musculus

<400>  45
tcaagtgtaa gttac                                                      15


<210>  46
<211>  9
<212>  DNA
<213>  Mus musculus

<400>  46
gacacatcc                                                              9


<210>  47
<211>  27
<212>  DNA
<213>  Mus musculus

<400>  47
cagcagtgga atagtaaccc acccacg                                         27


<210>  48
<211>  15
<212>  DNA
<213>  Mus musculus

<400>  48
agctactgga tgcac                                                      15


<210>  49
<211>  51
<212>  DNA
<213>  Mus musculus

<400>  49
gagattaatc ctagcaacgg tcgtactcac tacaatgaga agttcaggac c              51


<210>  50
<211>  24
<212>  DNA
<213>  Mus musculus

<400>  50
agggttggtt acctcatgga ctac                                            24


<210>  51
<211>  30
<212>  DNA
<213>  Mus musculus

<400>  51
agtgccagct caagtgtaag ttacatgcac                                      30


<210>  52
<211>  21
<212>  DNA
<213>  Mus musculus

<400>  52
gacacatcca aactggcttc t                                               21


<210>  53
<211>  351
<212>  DNA
<213>  Mus musculus

<400>  53
caggtccaac tgcagcagcc tggggctgaa ctggtgaagc ctggggcttc agtgaagctg     60

tcctgcaagg cttctggcta caccttcacc agctactgga tgcactgggt gaagcagagg    120

cctggacaag gccttgagtg gattggagag attaatccta gcaacggtcg tactcactac    180

aatgagaagt tcaggaccaa ggccacactg actgttgcca aatcctccat cacagcctac    240

atgcaactca gcaccctgac atctgaggac tctgcggtct attactgtgc aagaagggtt    300

ggttacctca tggactactg gggtcaagga acctcagtca ccgctcctca g             351


<210>  54
<211>  318
<212>  DNA
<213>  Mus musculus

<400>  54
caaattgttc tcacccagtc tccagcaatc atgtctgcat ctccagggga gaaggtcacc     60

atgacctgca gtgccagctc aagtgtaagt tacatgcact ggtaccagca gaagtcaggc    120

acctccccca aaagattgat ttatgacaca tccaaactgg cttctggagt ccctgctcgc    180

ttcagtggca gtgggtctgg gacctcttac tctctcacaa tcagcagcat ggaggctgaa    240

gatgctgcca cttattactg ccagcagtgg aatagtaacc cacccacgtt cggtgctggg    300

accaagctgg agctgaaa                                                  318


<210>  55
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  Sequence from CDR-H1


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is S or T

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is I or F

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is A or missing

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is F or W

<400>  55

Gly Tyr Xaa Xaa Thr Ser Xaa Tyr Xaa 
1               5                   


<210>  56
<211>  8
<212>  PRT
<213>  artificial

<220>
<223>  Sequence from CDR-H2


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is Y or P

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is D or S

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is N or missing

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is T or R

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is N or T

<400>  56

Ile Asn Xaa Xaa Xaa Gly Xaa Xaa 
1               5               


<210>  57
<211>  10
<212>  PRT
<213>  artificial

<220>
<223>  Sequence from CDR-H3


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is T or A

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is D or R

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is R or V

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is T or G

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is F or Y

<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa is A or L

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is M or missing

<220>
<221>  misc_feature
<222>  (9)..(9)
<223>  Xaa is D or missing

<400>  57

Xaa Arg Xaa Xaa Xaa Xaa Xaa Xaa Xaa Tyr 
1               5                   10  


<210>  58
<211>  6
<212>  PRT
<213>  artificial

<220>
<223>  Sequence from CDR-L1


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Q or missing

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is R or S

<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is I or S

<220>
<221>  misc_feature
<222>  (4)..(4)
<223>  Xaa is Y or V

<220>
<221>  misc_feature
<222>  (5)..(5)
<223>  Xaa is N or S

<400>  58

Xaa Xaa Xaa Xaa Xaa Tyr 
1               5       


<210>  59
<211>  3
<212>  PRT
<213>  artificial

<220>
<223>  Sequence from CDR-L2


<220>
<221>  misc_feature
<222>  (1)..(1)
<223>  Xaa is Y or D

<220>
<221>  misc_feature
<222>  (2)..(2)
<223>  Xaa is A or T

<400>  59

Xaa Xaa Ser 
1           


<210>  60
<211>  9
<212>  PRT
<213>  artificial

<220>
<223>  Sequence from CDR-L3


<220>
<221>  misc_feature
<222>  (3)..(3)
<223>  Xaa is S or W

<220>
<221>  misc_feature
<222>  (6)..(6)
<223>  Xaa is W or N

<220>
<221>  misc_feature
<222>  (8)..(8)
<223>  Xaa is L or P

<400>  60

Gln Gln Xaa Asn Ser Xaa Pro Xaa Thr 
1               5                   


