                         SEQUENCE LISTING

<110>  The Board of Trustees of the University of Illinois
       Bongarzone, Ernesto R.
 
<120>  COMPOSITIONS AND METHODS FOR THE TREATMENT OF KRABBE AND OTHER 
       NEURODEGENERATIVE DISEASES

<130>  121946-176370

<150>  61/232,607
<151>  2009-08-10

<150>  61/294,607
<151>  2010-01-13

<160>  59    

<170>  PatentIn version 3.5

<210>  1
<211>  24
<212>  DNA
<213>  GALC Forward

<400>  1
ctggatactc tatggctcct tgac                                              24


<210>  2
<211>  24
<212>  DNA
<213>  GALC Reverse

<400>  2
agtggtgagc gtaaatatct cgtc                                              24


<210>  3
<211>  24
<212>  DNA
<213>  CGT Forward

<400>  3
caataatccc agttatcggc agag                                              24


<210>  4
<211>  24
<212>  DNA
<213>  CGT Reverse

<400>  4
tccaataggt agtccgattg acag                                              24


<210>  5
<211>  21
<212>  DNA
<213>  RPLP0 Forward

<400>  5
cacgaagcta acgactatcg c                                                 21


<210>  6
<211>  20
<212>  DNA
<213>  RPLP0 Reverse

<400>  6
ctctagggac tcgttcgtgc                                                   20


<210>  7
<211>  48
<212>  RNA
<213>  Murine PP1

<400>  7
ccagaucguu uguacagaaa ucucgagauu ucuguacaaa cgaucugg                    48


<210>  8
<211>  49
<212>  RNA
<213>  Murine PP1

<400>  8
gucgucgagu cauccgcauu gauaucuagc ugaaauuacc gaguuaaga                   49


<210>  9
<211>  49
<212>  RNA
<213>  Murine PP1

<400>  9
ggcguccuug aaaguguuaa aucucgagau uuaacacuuu caaggacgc                   49


<210>  10
<211>  49
<212>  RNA
<213>  Murine PP1

<400>  10
gaaucugacc cucgguagca augauagagu uuaacacgcu uucuguaga                   49


<210>  11
<211>  41
<212>  PRT
<213>  Peptide for RVG-9R

<400>  11

Tyr Thr Ile Trp Met Pro Glu Asx Pro Arg Pro Gly Thr Pro Cys Asp 
1               5                   10                  15      


Ile Phe Thr Asn Ser Arg Gly Lys Arg Ala Ser Asn Gly Gly Gly Gly 
            20                  25                  30          


Arg Arg Arg Arg Arg Arg Arg Arg Arg 
        35                  40      


<210>  12
<211>  1356
<212>  PRT
<213>  Homo sapiens protein phosphatase 1, catalytic subunit, alpha isozyme (PPP1CA), transcript variant 2, mRNA

<400>  12

Gly Cys Gly Gly Gly Gly Cys Cys Gly Cys Gly Gly Gly Cys Cys Gly 
1               5                   10                  15      


Gly Gly Gly Gly Cys Gly Gly Ala Cys Thr Gly Gly Gly Gly Cys Gly 
            20                  25                  30          


Gly Gly Cys Gly Gly Ala Ala Gly Gly Ala Gly Ala Gly Cys Cys Ala 
        35                  40                  45              


Gly Gly Cys Cys Gly Gly Ala Ala Gly Gly Ala Gly Gly Cys Thr Gly 
    50                  55                  60                  


Cys Cys Gly Gly Ala Gly Gly Gly Cys Gly Gly Gly Ala Gly Gly Cys 
65                  70                  75                  80  


Ala Gly Gly Ala Gly Cys Gly Gly Gly Cys Cys Ala Gly Gly Ala Gly 
                85                  90                  95      


Cys Thr Gly Cys Thr Gly Gly Gly Cys Thr Gly Gly Ala Gly Cys Gly 
            100                 105                 110         


Gly Cys Gly Gly Cys Gly Cys Cys Gly Cys Cys Ala Thr Gly Thr Cys 
        115                 120                 125             


Cys Gly Ala Cys Ala Gly Cys Gly Ala Gly Ala Ala Gly Cys Thr Cys 
    130                 135                 140                 


Ala Ala Cys Cys Thr Gly Gly Ala Cys Thr Cys Gly Ala Thr Cys Ala 
145                 150                 155                 160 


Thr Cys Gly Gly Gly Cys Gly Cys Cys Thr Gly Cys Thr Gly Gly Ala 
                165                 170                 175     


Ala Gly Gly Thr Gly Ala Cys Ala Thr Ala Cys Ala Cys Gly Gly Cys 
            180                 185                 190         


Cys Ala Gly Thr Ala Cys Thr Ala Cys Gly Ala Cys Cys Thr Thr Cys 
        195                 200                 205             


Thr Gly Cys Gly Ala Cys Thr Ala Thr Thr Thr Gly Ala Gly Thr Ala 
    210                 215                 220                 


Thr Gly Gly Cys Gly Gly Thr Thr Thr Cys Cys Cys Thr Cys Cys Cys 
225                 230                 235                 240 


Gly Ala Gly Ala Gly Cys Ala Ala Cys Thr Ala Cys Cys Thr Cys Thr 
                245                 250                 255     


Thr Thr Cys Thr Gly Gly Gly Gly Gly Ala Cys Thr Ala Thr Gly Thr 
            260                 265                 270         


Gly Gly Ala Cys Ala Gly Gly Gly Gly Cys Ala Ala Gly Cys Ala Gly 
        275                 280                 285             


Thr Cys Cys Thr Thr Gly Gly Ala Gly Ala Cys Cys Ala Thr Cys Thr 
    290                 295                 300                 


Gly Cys Cys Thr Gly Cys Thr Gly Cys Thr Gly Gly Cys Cys Thr Ala 
305                 310                 315                 320 


Thr Ala Ala Gly Ala Thr Cys Ala Ala Gly Thr Ala Cys Cys Cys Cys 
                325                 330                 335     


Gly Ala Gly Ala Ala Cys Thr Thr Cys Thr Thr Cys Cys Thr Gly Cys 
            340                 345                 350         


Thr Cys Cys Gly Thr Gly Gly Gly Ala Ala Cys Cys Ala Cys Gly Ala 
        355                 360                 365             


Gly Thr Gly Thr Gly Cys Cys Ala Gly Cys Ala Thr Cys Ala Ala Cys 
    370                 375                 380                 


Cys Gly Cys Ala Thr Cys Thr Ala Thr Gly Gly Thr Thr Thr Cys Thr 
385                 390                 395                 400 


Ala Cys Gly Ala Thr Gly Ala Gly Thr Gly Cys Ala Ala Gly Ala Gly 
                405                 410                 415     


Ala Cys Gly Cys Thr Ala Cys Ala Ala Cys Ala Thr Cys Ala Ala Ala 
            420                 425                 430         


Cys Thr Gly Thr Gly Gly Ala Ala Ala Ala Cys Cys Thr Thr Cys Ala 
        435                 440                 445             


Cys Thr Gly Ala Cys Thr Gly Cys Thr Thr Cys Ala Ala Cys Thr Gly 
    450                 455                 460                 


Cys Cys Thr Gly Cys Cys Cys Ala Thr Cys Gly Cys Gly Gly Cys Cys 
465                 470                 475                 480 


Ala Thr Ala Gly Thr Gly Gly Ala Cys Gly Ala Ala Ala Ala Gly Ala 
                485                 490                 495     


Thr Cys Thr Thr Cys Thr Gly Cys Thr Gly Cys Cys Ala Cys Gly Gly 
            500                 505                 510         


Ala Gly Gly Cys Cys Thr Gly Thr Cys Cys Cys Cys Gly Gly Ala Cys 
        515                 520                 525             


Cys Thr Gly Cys Ala Gly Thr Cys Thr Ala Thr Gly Gly Ala Gly Cys 
    530                 535                 540                 


Ala Gly Ala Thr Thr Cys Gly Gly Cys Gly Gly Ala Thr Cys Ala Thr 
545                 550                 555                 560 


Gly Cys Gly Gly Cys Cys Cys Ala Cys Ala Gly Ala Thr Gly Thr Gly 
                565                 570                 575     


Cys Cys Thr Gly Ala Cys Cys Ala Gly Gly Gly Cys Cys Thr Gly Cys 
            580                 585                 590         


Thr Gly Thr Gly Thr Gly Ala Cys Cys Thr Gly Cys Thr Gly Thr Gly 
        595                 600                 605             


Gly Thr Cys Thr Gly Ala Cys Cys Cys Thr Gly Ala Cys Ala Ala Gly 
    610                 615                 620                 


Gly Ala Cys Gly Thr Gly Cys Ala Gly Gly Gly Cys Thr Gly Gly Gly 
625                 630                 635                 640 


Gly Cys Gly Ala Gly Ala Ala Cys Gly Ala Cys Cys Gly Thr Gly Gly 
                645                 650                 655     


Cys Gly Thr Cys Thr Cys Thr Thr Thr Thr Ala Cys Cys Thr Thr Thr 
            660                 665                 670         


Gly Gly Ala Gly Cys Cys Gly Ala Gly Gly Thr Gly Gly Thr Gly Gly 
        675                 680                 685             


Cys Cys Ala Ala Gly Thr Thr Cys Cys Thr Cys Cys Ala Cys Ala Ala 
    690                 695                 700                 


Gly Cys Ala Cys Gly Ala Cys Thr Thr Gly Gly Ala Cys Cys Thr Cys 
705                 710                 715                 720 


Ala Thr Cys Thr Gly Cys Cys Gly Ala Gly Cys Ala Cys Ala Cys Cys 
                725                 730                 735     


Ala Gly Gly Thr Gly Gly Thr Ala Gly Ala Ala Gly Ala Cys Gly Gly 
            740                 745                 750         


Cys Thr Ala Cys Gly Ala Gly Thr Thr Cys Thr Thr Thr Gly Cys Cys 
        755                 760                 765             


Ala Ala Gly Cys Gly Gly Cys Ala Gly Cys Thr Gly Gly Thr Gly Ala 
    770                 775                 780                 


Cys Ala Cys Thr Thr Thr Thr Cys Thr Cys Ala Gly Cys Thr Cys Cys 
785                 790                 795                 800 


Cys Ala Ala Cys Thr Ala Cys Thr Gly Thr Gly Gly Cys Gly Ala Gly 
                805                 810                 815     


Thr Thr Thr Gly Ala Cys Ala Ala Thr Gly Cys Thr Gly Gly Cys Gly 
            820                 825                 830         


Cys Cys Ala Thr Gly Ala Thr Gly Ala Gly Thr Gly Thr Gly Gly Ala 
        835                 840                 845             


Cys Gly Ala Gly Ala Cys Cys Cys Thr Cys Ala Thr Gly Thr Gly Cys 
    850                 855                 860                 


Thr Cys Thr Thr Thr Cys Cys Ala Gly Ala Thr Cys Cys Thr Cys Ala 
865                 870                 875                 880 


Ala Gly Cys Cys Cys Gly Cys Cys Gly Ala Cys Ala Ala Gly Ala Ala 
                885                 890                 895     


Cys Ala Ala Gly Gly Gly Gly Ala Ala Gly Thr Ala Cys Gly Gly Gly 
            900                 905                 910         


Cys Ala Gly Thr Thr Cys Ala Gly Thr Gly Gly Cys Cys Thr Gly Ala 
        915                 920                 925             


Ala Cys Cys Cys Thr Gly Gly Ala Gly Gly Cys Cys Gly Ala Cys Cys 
    930                 935                 940                 


Cys Ala Thr Cys Ala Cys Cys Cys Cys Ala Cys Cys Cys Cys Gly Cys 
945                 950                 955                 960 


Ala Ala Thr Thr Cys Cys Gly Cys Cys Ala Ala Ala Gly Cys Cys Ala 
                965                 970                 975     


Ala Gly Ala Ala Ala Thr Ala Gly Cys Cys Cys Cys Cys Gly Cys Ala 
            980                 985                 990         


Cys Ala Cys Cys Ala Cys Cys Cys  Thr Gly Thr Gly Cys  Cys Cys Cys 
        995                 1000                 1005             


Ala Gly  Ala Thr Gly Ala Thr  Gly Gly Ala Thr Thr  Gly Ala Thr 
    1010                 1015                 1020             


Thr Gly  Thr Ala Cys Ala Gly  Ala Ala Ala Thr Cys  Ala Thr Gly 
    1025                 1030                 1035             


Cys Thr  Gly Cys Cys Ala Thr  Gly Cys Thr Gly Gly  Gly Gly Gly 
    1040                 1045                 1050             


Gly Gly  Gly Gly Thr Cys Ala  Cys Cys Cys Cys Gly  Ala Cys Cys 
    1055                 1060                 1065             


Cys Cys  Thr Cys Ala Gly Gly  Cys Cys Cys Ala Cys  Cys Thr Gly 
    1070                 1075                 1080             


Thr Cys  Ala Cys Gly Gly Gly  Gly Ala Ala Cys Ala  Thr Gly Gly 
    1085                 1090                 1095             


Ala Gly  Cys Cys Thr Thr Gly  Gly Thr Gly Thr Ala  Thr Thr Thr 
    1100                 1105                 1110             


Thr Thr  Cys Thr Thr Thr Thr  Cys Thr Thr Thr Thr  Thr Thr Thr 
    1115                 1120                 1125             


Ala Ala  Thr Gly Ala Ala Thr  Cys Ala Ala Thr Ala  Gly Cys Ala 
    1130                 1135                 1140             


Gly Cys  Gly Thr Cys Cys Ala  Gly Thr Cys Cys Cys  Cys Cys Ala 
    1145                 1150                 1155             


Gly Gly  Gly Cys Thr Gly Cys  Thr Thr Cys Cys Thr  Gly Cys Cys 
    1160                 1165                 1170             


Thr Gly  Cys Ala Cys Cys Thr  Gly Cys Gly Gly Thr  Gly Ala Cys 
    1175                 1180                 1185             


Thr Gly  Thr Gly Ala Gly Cys  Ala Gly Gly Ala Thr  Cys Cys Thr 
    1190                 1195                 1200             


Gly Gly  Gly Gly Cys Cys Gly  Ala Gly Gly Cys Thr  Gly Cys Ala 
    1205                 1210                 1215             


Gly Cys  Thr Cys Ala Gly Gly  Gly Cys Ala Ala Cys  Gly Gly Cys 
    1220                 1225                 1230             


Ala Gly  Gly Cys Cys Ala Gly  Gly Thr Cys Gly Thr  Gly Gly Gly 
    1235                 1240                 1245             


Thr Cys  Thr Cys Cys Ala Gly  Cys Cys Gly Thr Gly  Cys Thr Thr 
    1250                 1255                 1260             


Gly Gly  Cys Cys Thr Cys Ala  Gly Gly Gly Cys Thr  Gly Gly Cys 
    1265                 1270                 1275             


Ala Gly  Cys Cys Gly Gly Ala  Thr Cys Cys Thr Gly  Gly Gly Gly 
    1280                 1285                 1290             


Cys Ala  Ala Cys Cys Cys Ala  Thr Cys Thr Gly Gly  Thr Cys Thr 
    1295                 1300                 1305             


Cys Thr  Thr Gly Ala Ala Thr  Ala Ala Ala Gly Gly  Thr Cys Ala 
    1310                 1315                 1320             


Ala Ala  Gly Cys Thr Gly Gly  Ala Thr Thr Cys Thr  Cys Gly Cys 
    1325                 1330                 1335             


Ala Ala  Ala Ala Ala Ala Ala  Ala Ala Ala Ala Ala  Ala Ala Ala 
    1340                 1345                 1350             


Ala Ala  Ala 
    1355     


<210>  13
<211>  1363
<212>  PRT
<213>  Mus musculus protein phosphatase 1, catalytic subunit, alpha isoform (Ppp1ca), mRNA

<400>  13

Ala Gly Gly Ala Gly Ala Gly Gly Gly Cys Cys Cys Gly Gly Ala Gly 
1               5                   10                  15      


Cys Thr Gly Gly Thr Gly Gly Gly Cys Cys Gly Gly Ala Gly Cys Gly 
            20                  25                  30          


Gly Cys Gly Gly Cys Gly Cys Cys Gly Cys Cys Ala Thr Gly Thr Cys 
        35                  40                  45              


Cys Gly Ala Cys Ala Gly Cys Gly Ala Gly Ala Ala Gly Cys Thr Cys 
    50                  55                  60                  


Ala Ala Cys Cys Thr Gly Gly Ala Cys Thr Cys Cys Ala Thr Cys Ala 
65                  70                  75                  80  


Thr Cys Gly Gly Gly Cys Gly Cys Cys Thr Gly Cys Thr Gly Gly Ala 
                85                  90                  95      


Ala Gly Thr Gly Cys Ala Gly Gly Gly Cys Thr Cys Ala Cys Gly Gly 
            100                 105                 110         


Cys Cys Thr Gly Gly Gly Ala Ala Gly Ala Ala Cys Gly Thr Gly Cys 
        115                 120                 125             


Ala Gly Cys Thr Gly Ala Cys Ala Gly Ala Gly Ala Ala Cys Gly Ala 
    130                 135                 140                 


Gly Ala Thr Cys Cys Gly Thr Gly Gly Thr Cys Thr Gly Thr Gly Cys 
145                 150                 155                 160 


Cys Thr Cys Ala Ala Ala Thr Cys Cys Cys Gly Gly Gly Ala Gly Ala 
                165                 170                 175     


Thr Thr Thr Thr Cys Cys Thr Gly Ala Gly Cys Cys Ala Gly Cys Cys 
            180                 185                 190         


Cys Ala Thr Thr Cys Thr Thr Cys Thr Gly Gly Ala Gly Cys Thr Thr 
        195                 200                 205             


Gly Ala Gly Gly Cys Gly Cys Cys Cys Cys Thr Cys Ala Ala Gly Ala 
    210                 215                 220                 


Thr Cys Thr Gly Thr Gly Gly Thr Gly Ala Cys Ala Thr Cys Cys Ala 
225                 230                 235                 240 


Thr Gly Gly Cys Cys Ala Gly Thr Ala Cys Thr Ala Thr Gly Ala Cys 
                245                 250                 255     


Cys Thr Thr Cys Thr Ala Cys Gly Gly Cys Thr Gly Thr Thr Thr Gly 
            260                 265                 270         


Ala Gly Thr Ala Thr Gly Gly Thr Gly Gly Cys Thr Thr Cys Cys Cys 
        275                 280                 285             


Thr Cys Cys Ala Gly Ala Gly Ala Gly Cys Ala Ala Cys Thr Ala Cys 
    290                 295                 300                 


Cys Thr Cys Thr Thr Cys Thr Thr Gly Gly Gly Gly Gly Ala Thr Thr 
305                 310                 315                 320 


Ala Thr Gly Thr Ala Gly Ala Thr Cys Gly Gly Gly Gly Cys Ala Ala 
                325                 330                 335     


Gly Cys Ala Gly Thr Cys Thr Thr Thr Gly Gly Ala Gly Ala Cys Cys 
            340                 345                 350         


Ala Thr Cys Thr Gly Cys Cys Thr Gly Thr Thr Gly Cys Thr Gly Gly 
        355                 360                 365             


Cys Cys Thr Ala Thr Ala Ala Gly Ala Thr Cys Ala Gly Ala Thr Ala 
    370                 375                 380                 


Cys Cys Cys Gly Gly Ala Gly Ala Ala Thr Thr Thr Cys Thr Thr Thr 
385                 390                 395                 400 


Cys Thr Ala Cys Thr Thr Cys Gly Thr Gly Gly Gly Ala Ala Cys Cys 
                405                 410                 415     


Ala Thr Gly Ala Gly Thr Gly Thr Gly Cys Cys Ala Gly Cys Ala Thr 
            420                 425                 430         


Cys Ala Ala Cys Cys Gly Cys Ala Thr Thr Thr Ala Thr Gly Gly Cys 
        435                 440                 445             


Thr Thr Cys Thr Ala Thr Gly Ala Thr Gly Ala Ala Thr Gly Cys Ala 
    450                 455                 460                 


Ala Gly Ala Gly Ala Ala Gly Ala Thr Ala Cys Ala Ala Cys Ala Thr 
465                 470                 475                 480 


Cys Ala Ala Ala Cys Thr Gly Thr Gly Gly Ala Ala Gly Ala Cys Gly 
                485                 490                 495     


Thr Thr Cys Ala Cys Thr Gly Ala Cys Thr Gly Cys Thr Thr Cys Ala 
            500                 505                 510         


Ala Cys Thr Gly Cys Cys Thr Gly Cys Cys Cys Ala Thr Thr Gly Cys 
        515                 520                 525             


Ala Gly Cys Cys Ala Thr Thr Gly Thr Gly Gly Ala Thr Gly Ala Gly 
    530                 535                 540                 


Ala Ala Gly Ala Thr Cys Thr Thr Cys Thr Gly Cys Thr Gly Cys Cys 
545                 550                 555                 560 


Ala Cys Gly Gly Gly Gly Gly Cys Cys Thr Gly Thr Cys Thr Cys Cys 
                565                 570                 575     


Ala Gly Ala Cys Thr Thr Gly Cys Ala Ala Thr Cys Cys Ala Thr Gly 
            580                 585                 590         


Gly Ala Gly Cys Ala Gly Ala Thr Thr Ala Gly Gly Cys Gly Thr Ala 
        595                 600                 605             


Thr Thr Ala Thr Gly Cys Gly Gly Cys Cys Cys Ala Cys Ala Gly Ala 
    610                 615                 620                 


Cys Gly Thr Gly Cys Cys Thr Gly Ala Cys Cys Ala Gly Gly Gly Cys 
625                 630                 635                 640 


Cys Thr Ala Cys Thr Gly Thr Gly Thr Gly Ala Thr Cys Thr Cys Cys 
                645                 650                 655     


Thr Gly Thr Gly Gly Thr Cys Thr Gly Ala Cys Cys Cys Thr Gly Ala 
            660                 665                 670         


Cys Ala Ala Gly Gly Ala Thr Gly Thr Thr Cys Ala Ala Gly Gly Cys 
        675                 680                 685             


Thr Gly Gly Gly Gly Cys Gly Ala Gly Ala Ala Thr Gly Ala Cys Cys 
    690                 695                 700                 


Gly Thr Gly Gly Thr Gly Thr Cys Thr Cys Cys Thr Thr Thr Ala Cys 
705                 710                 715                 720 


Cys Thr Thr Thr Gly Gly Gly Gly Cys Thr Gly Ala Gly Gly Thr Gly 
                725                 730                 735     


Gly Thr Ala Gly Cys Cys Ala Ala Gly Thr Thr Cys Cys Thr Gly Cys 
            740                 745                 750         


Ala Cys Ala Ala Gly Cys Ala Thr Gly Ala Thr Thr Thr Gly Gly Ala 
        755                 760                 765             


Cys Cys Thr Cys Ala Thr Cys Thr Gly Cys Ala Gly Ala Gly Cys Ala 
    770                 775                 780                 


Cys Ala Thr Cys Ala Gly Gly Thr Thr Gly Thr Ala Gly Ala Ala Gly 
785                 790                 795                 800 


Ala Thr Gly Gly Cys Thr Ala Thr Gly Ala Gly Thr Thr Cys Thr Thr 
                805                 810                 815     


Thr Gly Cys Cys Ala Ala Gly Ala Gly Ala Cys Ala Gly Thr Thr Gly 
            820                 825                 830         


Gly Thr Gly Ala Cys Ala Cys Thr Cys Thr Thr Cys Thr Cys Ala Gly 
        835                 840                 845             


Cys Thr Cys Cys Cys Ala Ala Cys Thr Ala Cys Thr Gly Thr Gly Gly 
    850                 855                 860                 


Ala Gly Ala Gly Thr Thr Thr Gly Ala Cys Ala Ala Thr Gly Cys Thr 
865                 870                 875                 880 


Gly Gly Thr Gly Cys Cys Ala Thr Gly Ala Thr Gly Ala Gly Thr Gly 
                885                 890                 895     


Thr Gly Gly Ala Thr Gly Ala Gly Ala Cys Cys Cys Thr Cys Ala Thr 
            900                 905                 910         


Gly Thr Gly Thr Thr Cys Cys Thr Thr Cys Cys Ala Gly Ala Thr Cys 
        915                 920                 925             


Cys Thr Cys Ala Ala Gly Cys Cys Cys Gly Cys Thr Gly Ala Thr Ala 
    930                 935                 940                 


Ala Gly Ala Ala Thr Ala Ala Gly Gly Gly Cys Ala Ala Gly Thr Ala 
945                 950                 955                 960 


Thr Gly Gly Gly Cys Ala Gly Thr Thr Cys Ala Gly Cys Gly Gly Cys 
                965                 970                 975     


Cys Thr Gly Ala Ala Cys Cys Cys Cys Gly Gly Ala Gly Gly Cys Cys 
            980                 985                 990         


Gly Gly Cys Cys Cys Ala Thr Cys  Ala Cys Thr Cys Cys  Ala Cys Cys 
        995                 1000                 1005             


Cys Cys  Gly Cys Ala Ala Thr  Thr Cys Thr Gly Cys  Cys Ala Ala 
    1010                 1015                 1020             


Ala Gly  Cys Cys Ala Ala Gly  Ala Ala Ala Thr Ala  Gly Cys Cys 
    1025                 1030                 1035             


Thr Cys  Cys Ala Thr Gly Thr  Gly Cys Thr Gly Cys  Cys Cys Thr 
    1040                 1045                 1050             


Thr Cys  Thr Gly Cys Cys Cys  Cys Ala Gly Ala Thr  Cys Gly Thr 
    1055                 1060                 1065             


Thr Thr  Gly Thr Ala Cys Ala  Gly Ala Ala Ala Thr  Cys Ala Thr 
    1070                 1075                 1080             


Gly Cys  Thr Gly Cys Cys Ala  Thr Gly Gly Gly Thr  Cys Ala Cys 
    1085                 1090                 1095             


Ala Cys  Thr Gly Gly Cys Cys  Thr Cys Thr Cys Ala  Gly Gly Cys 
    1100                 1105                 1110             


Cys Cys  Ala Cys Cys Cys Gly  Thr Cys Ala Cys Gly  Gly Gly Gly 
    1115                 1120                 1125             


Ala Ala  Cys Ala Cys Ala Cys  Ala Gly Cys Gly Thr  Thr Ala Ala 
    1130                 1135                 1140             


Gly Thr  Gly Thr Cys Thr Thr  Thr Cys Cys Thr Thr  Thr Ala Thr 
    1145                 1150                 1155             


Thr Thr  Thr Thr Thr Ala Ala  Ala Gly Ala Ala Thr  Cys Ala Ala 
    1160                 1165                 1170             


Thr Ala  Gly Cys Ala Gly Cys  Ala Thr Cys Thr Ala  Ala Thr Cys 
    1175                 1180                 1185             


Thr Cys  Cys Cys Ala Gly Gly  Gly Cys Thr Cys Cys  Cys Thr Cys 
    1190                 1195                 1200             


Cys Cys  Ala Cys Cys Ala Gly  Cys Ala Cys Cys Thr  Gly Thr Gly 
    1205                 1210                 1215             


Gly Thr  Gly Gly Cys Thr Gly  Cys Ala Ala Gly Thr  Gly Gly Ala 
    1220                 1225                 1230             


Ala Thr  Cys Cys Thr Gly Gly  Gly Gly Cys Cys Ala  Ala Gly Gly 
    1235                 1240                 1245             


Cys Thr  Gly Cys Ala Gly Cys  Thr Cys Ala Gly Gly  Gly Cys Ala 
    1250                 1255                 1260             


Ala Thr  Gly Gly Cys Ala Gly  Ala Cys Cys Ala Gly  Ala Thr Thr 
    1265                 1270                 1275             


Gly Thr  Gly Gly Gly Thr Cys  Thr Cys Cys Ala Gly  Cys Cys Thr 
    1280                 1285                 1290             


Thr Gly  Cys Ala Thr Gly Gly  Cys Thr Gly Gly Cys  Ala Gly Cys 
    1295                 1300                 1305             


Cys Ala  Gly Ala Thr Cys Cys  Thr Gly Gly Gly Gly  Cys Ala Ala 
    1310                 1315                 1320             


Cys Cys  Cys Ala Thr Cys Thr  Gly Gly Thr Cys Thr  Cys Thr Thr 
    1325                 1330                 1335             


Gly Ala  Ala Thr Ala Ala Ala  Gly Gly Thr Cys Ala  Ala Ala Gly 
    1340                 1345                 1350             


Cys Thr  Gly Gly Ala Thr Thr  Cys Thr Cys 
    1355                 1360             


<210>  14
<211>  4991
<212>  PRT
<213>  Homo sapiens protein phosphatase 1, catalytic subunit, beta isozyme (PPP1CB), transcript variant 1, mRNA

<400>  14

Gly Gly Cys Gly Gly Cys Gly Cys Gly Cys Ala Ala Gly Gly Gly Ala 
1               5                   10                  15      


Cys Gly Thr Gly Cys Gly Gly Ala Gly Thr Gly Ala Gly Thr Gly Gly 
            20                  25                  30          


Cys Gly Cys Thr Gly Cys Gly Gly Gly Thr Gly Gly Gly Gly Cys Cys 
        35                  40                  45              


Gly Thr Cys Gly Gly Cys Gly Gly Cys Gly Cys Thr Gly Gly Thr Gly 
    50                  55                  60                  


Ala Gly Cys Thr Thr Thr Gly Cys Gly Gly Ala Gly Cys Thr Gly Gly 
65                  70                  75                  80  


Gly Cys Gly Gly Thr Gly Cys Cys Gly Ala Gly Gly Ala Gly Gly Ala 
                85                  90                  95      


Gly Gly Ala Gly Gly Thr Gly Gly Cys Gly Gly Cys Cys Thr Gly Gly 
            100                 105                 110         


Gly Thr Cys Thr Gly Ala Cys Gly Cys Gly Gly Cys Cys Cys Thr Gly 
        115                 120                 125             


Thr Thr Cys Gly Ala Gly Gly Gly Gly Gly Cys Cys Thr Cys Thr Cys 
    130                 135                 140                 


Thr Thr Gly Thr Thr Thr Ala Thr Thr Thr Ala Thr Thr Thr Ala Thr 
145                 150                 155                 160 


Thr Thr Thr Cys Cys Gly Thr Gly Gly Gly Thr Gly Cys Cys Thr Cys 
                165                 170                 175     


Cys Gly Ala Gly Thr Gly Thr Gly Cys Gly Cys Gly Cys Gly Cys Thr 
            180                 185                 190         


Cys Thr Cys Gly Cys Thr Ala Cys Cys Cys Gly Gly Cys Gly Gly Gly 
        195                 200                 205             


Gly Ala Gly Gly Gly Gly Gly Thr Gly Gly Gly Gly Gly Gly Ala Gly 
    210                 215                 220                 


Gly Gly Cys Cys Cys Gly Gly Gly Ala Ala Ala Ala Gly Gly Gly Gly 
225                 230                 235                 240 


Gly Ala Gly Thr Thr Gly Gly Ala Gly Cys Cys Gly Gly Gly Gly Thr 
                245                 250                 255     


Cys Gly Ala Ala Ala Cys Gly Cys Cys Gly Cys Gly Thr Gly Ala Cys 
            260                 265                 270         


Thr Thr Gly Thr Ala Gly Gly Thr Gly Ala Gly Ala Gly Ala Ala Cys 
        275                 280                 285             


Gly Cys Cys Gly Ala Gly Cys Cys Gly Thr Cys Gly Cys Cys Gly Cys 
    290                 295                 300                 


Ala Gly Cys Cys Thr Cys Cys Gly Cys Cys Gly Cys Cys Gly Ala Gly 
305                 310                 315                 320 


Ala Ala Gly Cys Cys Cys Thr Thr Gly Thr Thr Cys Cys Cys Gly Cys 
                325                 330                 335     


Thr Gly Cys Thr Gly Gly Gly Ala Ala Gly Gly Ala Gly Ala Gly Thr 
            340                 345                 350         


Cys Thr Gly Thr Gly Cys Cys Gly Ala Cys Ala Ala Gly Ala Thr Gly 
        355                 360                 365             


Gly Cys Gly Gly Ala Cys Gly Gly Gly Gly Ala Gly Cys Thr Gly Ala 
    370                 375                 380                 


Ala Cys Gly Thr Gly Gly Ala Cys Ala Gly Cys Cys Thr Cys Ala Thr 
385                 390                 395                 400 


Cys Ala Cys Cys Cys Gly Gly Cys Thr Gly Cys Thr Gly Gly Ala Gly 
                405                 410                 415     


Gly Thr Ala Cys Gly Ala Gly Gly Ala Thr Gly Thr Cys Gly Thr Cys 
            420                 425                 430         


Cys Ala Gly Gly Ala Ala Ala Gly Ala Thr Thr Gly Thr Gly Cys Ala 
        435                 440                 445             


Gly Ala Thr Gly Ala Cys Thr Gly Ala Ala Gly Cys Ala Gly Ala Ala 
    450                 455                 460                 


Gly Thr Thr Cys Gly Ala Gly Gly Cys Thr Thr Ala Thr Gly Thr Ala 
465                 470                 475                 480 


Thr Cys Ala Ala Gly Thr Cys Thr Cys Gly Gly Gly Ala Gly Ala Thr 
                485                 490                 495     


Cys Thr Thr Thr Cys Thr Cys Ala Gly Cys Cys Ala Gly Cys Cys Thr 
            500                 505                 510         


Ala Thr Thr Cys Thr Thr Thr Thr Gly Gly Ala Ala Thr Thr Gly Gly 
        515                 520                 525             


Ala Ala Gly Cys Ala Cys Cys Gly Cys Thr Gly Ala Ala Ala Ala Thr 
    530                 535                 540                 


Thr Thr Gly Thr Gly Gly Ala Gly Ala Thr Ala Thr Thr Cys Ala Thr 
545                 550                 555                 560 


Gly Gly Ala Cys Ala Ala Thr Ala Thr Ala Cys Ala Gly Ala Thr Thr 
                565                 570                 575     


Thr Ala Cys Thr Gly Ala Gly Ala Thr Thr Ala Thr Thr Thr Gly Ala 
            580                 585                 590         


Ala Thr Ala Thr Gly Gly Ala Gly Gly Thr Thr Thr Cys Cys Cys Ala 
        595                 600                 605             


Cys Cys Ala Gly Ala Ala Gly Cys Cys Ala Ala Cys Thr Ala Thr Cys 
    610                 615                 620                 


Thr Thr Thr Thr Cys Thr Thr Ala Gly Gly Ala Gly Ala Thr Thr Ala 
625                 630                 635                 640 


Thr Gly Thr Gly Gly Ala Cys Ala Gly Ala Gly Gly Ala Ala Ala Gly 
                645                 650                 655     


Cys Ala Gly Thr Cys Thr Thr Thr Gly Gly Ala Ala Ala Cys Cys Ala 
            660                 665                 670         


Thr Thr Thr Gly Thr Thr Thr Gly Cys Thr Ala Thr Thr Gly Gly Cys 
        675                 680                 685             


Thr Thr Ala Thr Ala Ala Ala Ala Thr Cys Ala Ala Ala Thr Ala Thr 
    690                 695                 700                 


Cys Cys Ala Gly Ala Gly Ala Ala Cys Thr Thr Cys Thr Thr Thr Cys 
705                 710                 715                 720 


Thr Cys Thr Thr Ala Ala Gly Ala Gly Gly Ala Ala Ala Cys Cys Ala 
                725                 730                 735     


Thr Gly Ala Gly Thr Gly Thr Gly Cys Thr Ala Gly Cys Ala Thr Cys 
            740                 745                 750         


Ala Ala Thr Cys Gly Cys Ala Thr Thr Thr Ala Thr Gly Gly Ala Thr 
        755                 760                 765             


Thr Cys Thr Ala Thr Gly Ala Thr Gly Ala Ala Thr Gly Cys Ala Ala 
    770                 775                 780                 


Ala Cys Gly Ala Ala Gly Ala Thr Thr Thr Ala Ala Thr Ala Thr Thr 
785                 790                 795                 800 


Ala Ala Ala Thr Thr Gly Thr Gly Gly Ala Ala Gly Ala Cys Cys Thr 
                805                 810                 815     


Thr Cys Ala Cys Thr Gly Ala Thr Thr Gly Thr Thr Thr Thr Ala Ala 
            820                 825                 830         


Cys Thr Gly Thr Cys Thr Gly Cys Cys Thr Ala Thr Ala Gly Cys Ala 
        835                 840                 845             


Gly Cys Cys Ala Thr Thr Gly Thr Gly Gly Ala Thr Gly Ala Gly Ala 
    850                 855                 860                 


Ala Gly Ala Thr Cys Thr Thr Cys Thr Gly Thr Thr Gly Thr Cys Ala 
865                 870                 875                 880 


Thr Gly Gly Ala Gly Gly Ala Thr Thr Gly Thr Cys Ala Cys Cys Ala 
                885                 890                 895     


Gly Ala Cys Cys Thr Gly Cys Ala Ala Thr Cys Thr Ala Thr Gly Gly 
            900                 905                 910         


Ala Gly Cys Ala Gly Ala Thr Thr Cys Gly Gly Ala Gly Ala Ala Thr 
        915                 920                 925             


Thr Ala Thr Gly Ala Gly Ala Cys Cys Thr Ala Cys Thr Gly Ala Thr 
    930                 935                 940                 


Gly Thr Cys Cys Cys Thr Gly Ala Thr Ala Cys Ala Gly Gly Thr Thr 
945                 950                 955                 960 


Thr Gly Cys Thr Cys Thr Gly Thr Gly Ala Thr Thr Thr Gly Cys Thr 
                965                 970                 975     


Ala Thr Gly Gly Thr Cys Thr Gly Ala Thr Cys Cys Ala Gly Ala Thr 
            980                 985                 990         


Ala Ala Gly Gly Ala Thr Gly Thr  Gly Cys Ala Ala Gly  Gly Cys Thr 
        995                 1000                 1005             


Gly Gly  Gly Gly Ala Gly Ala  Ala Ala Ala Thr Gly  Ala Thr Cys 
    1010                 1015                 1020             


Gly Thr  Gly Gly Thr Gly Thr  Thr Thr Cys Cys Thr  Thr Thr Ala 
    1025                 1030                 1035             


Cys Thr  Thr Thr Thr Gly Gly  Ala Gly Cys Thr Gly  Ala Thr Gly 
    1040                 1045                 1050             


Thr Ala  Gly Thr Cys Ala Gly  Thr Ala Ala Ala Thr  Thr Thr Cys 
    1055                 1060                 1065             


Thr Gly  Ala Ala Thr Cys Gly  Thr Cys Ala Thr Gly  Ala Thr Thr 
    1070                 1075                 1080             


Thr Ala  Gly Ala Thr Thr Thr  Gly Ala Thr Thr Thr  Gly Thr Cys 
    1085                 1090                 1095             


Gly Ala  Gly Cys Thr Cys Ala  Thr Cys Ala Gly Gly  Thr Gly Gly 
    1100                 1105                 1110             


Thr Gly  Gly Ala Ala Gly Ala  Thr Gly Gly Ala Thr  Ala Thr Gly 
    1115                 1120                 1125             


Ala Ala  Thr Thr Thr Thr Thr  Thr Gly Cys Thr Ala  Ala Ala Cys 
    1130                 1135                 1140             


Gly Ala  Cys Ala Gly Thr Thr  Gly Gly Thr Ala Ala  Cys Cys Thr 
    1145                 1150                 1155             


Thr Ala  Thr Thr Thr Thr Cys  Ala Gly Cys Cys Cys  Cys Ala Ala 
    1160                 1165                 1170             


Ala Thr  Thr Ala Cys Thr Gly  Thr Gly Gly Cys Gly  Ala Gly Thr 
    1175                 1180                 1185             


Thr Thr  Gly Ala Thr Ala Ala  Thr Gly Cys Thr Gly  Gly Thr Gly 
    1190                 1195                 1200             


Gly Ala  Ala Thr Gly Ala Thr  Gly Ala Gly Thr Gly  Thr Gly Gly 
    1205                 1210                 1215             


Ala Thr  Gly Ala Ala Ala Cys  Thr Thr Thr Gly Ala  Thr Gly Thr 
    1220                 1225                 1230             


Gly Thr  Thr Cys Ala Thr Thr  Thr Cys Ala Gly Ala  Thr Ala Thr 
    1235                 1240                 1245             


Thr Gly  Ala Ala Ala Cys Cys  Ala Thr Cys Thr Gly  Ala Ala Ala 
    1250                 1255                 1260             


Ala Gly  Ala Ala Ala Gly Cys  Thr Ala Ala Ala Thr  Ala Cys Cys 
    1265                 1270                 1275             


Ala Gly  Thr Ala Thr Gly Gly  Thr Gly Gly Ala Cys  Thr Gly Ala 
    1280                 1285                 1290             


Ala Thr  Thr Cys Thr Gly Gly  Ala Cys Gly Thr Cys  Cys Thr Gly 
    1295                 1300                 1305             


Thr Cys  Ala Cys Thr Cys Cys  Ala Cys Cys Thr Cys  Gly Ala Ala 
    1310                 1315                 1320             


Cys Ala  Gly Cys Thr Ala Ala  Thr Cys Cys Gly Cys  Cys Gly Ala 
    1325                 1330                 1335             


Ala Gly  Ala Ala Ala Ala Gly  Gly Thr Gly Ala Ala  Gly Ala Ala 
    1340                 1345                 1350             


Ala Gly  Gly Ala Ala Thr Thr  Cys Thr Gly Thr Ala  Ala Ala Gly 
    1355                 1360                 1365             


Ala Ala  Ala Cys Cys Ala Thr  Cys Ala Gly Ala Thr  Thr Thr Gly 
    1370                 1375                 1380             


Thr Thr  Ala Ala Gly Gly Ala  Cys Ala Thr Ala Cys  Thr Thr Cys 
    1385                 1390                 1395             


Ala Thr  Ala Ala Thr Ala Thr  Ala Thr Ala Ala Gly  Thr Gly Thr 
    1400                 1405                 1410             


Gly Cys  Ala Cys Thr Gly Thr  Ala Ala Ala Ala Cys  Cys Ala Thr 
    1415                 1420                 1425             


Cys Cys  Ala Gly Cys Cys Ala  Thr Thr Thr Gly Ala  Cys Ala Cys 
    1430                 1435                 1440             


Cys Cys  Thr Thr Thr Ala Thr  Gly Ala Thr Gly Thr  Cys Ala Cys 
    1445                 1450                 1455             


Ala Cys  Cys Thr Thr Thr Ala  Ala Cys Thr Thr Ala  Ala Gly Gly 
    1460                 1465                 1470             


Ala Gly  Ala Cys Gly Gly Gly  Thr Ala Ala Ala Gly  Gly Ala Thr 
    1475                 1480                 1485             


Cys Thr  Thr Ala Ala Ala Thr  Thr Thr Thr Thr Thr  Thr Cys Thr 
    1490                 1495                 1500             


Ala Ala  Thr Ala Gly Ala Ala  Ala Gly Ala Thr Gly  Thr Gly Cys 
    1505                 1510                 1515             


Thr Ala  Cys Ala Cys Thr Gly  Thr Ala Thr Thr Gly  Thr Ala Ala 
    1520                 1525                 1530             


Thr Ala  Ala Gly Thr Ala Thr  Ala Cys Thr Cys Thr  Gly Thr Thr 
    1535                 1540                 1545             


Ala Thr  Ala Gly Thr Cys Ala  Ala Cys Ala Ala Ala  Gly Thr Thr 
    1550                 1555                 1560             


Ala Ala  Ala Thr Cys Cys Ala  Ala Ala Thr Thr Cys  Ala Ala Ala 
    1565                 1570                 1575             


Ala Thr  Thr Ala Thr Cys Cys  Ala Thr Thr Ala Ala  Ala Gly Thr 
    1580                 1585                 1590             


Thr Ala  Cys Ala Thr Cys Thr  Thr Cys Ala Thr Gly  Thr Ala Thr 
    1595                 1600                 1605             


Cys Ala  Cys Ala Ala Thr Thr  Thr Thr Thr Ala Ala  Ala Gly Thr 
    1610                 1615                 1620             


Thr Gly  Ala Ala Ala Ala Gly  Cys Ala Thr Cys Cys  Cys Ala Gly 
    1625                 1630                 1635             


Thr Thr  Ala Ala Ala Cys Thr  Ala Gly Ala Thr Gly  Thr Gly Ala 
    1640                 1645                 1650             


Thr Ala  Gly Thr Thr Ala Ala  Ala Cys Cys Ala Gly  Ala Thr Gly 
    1655                 1660                 1665             


Ala Ala  Ala Gly Cys Ala Thr  Gly Ala Thr Gly Ala  Thr Cys Cys 
    1670                 1675                 1680             


Ala Thr  Cys Thr Gly Thr Gly  Thr Ala Ala Thr Gly  Thr Gly Gly 
    1685                 1690                 1695             


Thr Thr  Thr Thr Ala Gly Thr  Gly Thr Thr Gly Cys  Thr Thr Gly 
    1700                 1705                 1710             


Gly Thr  Thr Gly Thr Thr Thr  Ala Ala Thr Thr Ala  Thr Thr Thr 
    1715                 1720                 1725             


Thr Gly  Ala Gly Cys Thr Thr  Gly Thr Thr Thr Thr  Gly Thr Thr 
    1730                 1735                 1740             


Thr Thr  Thr Gly Thr Thr Thr  Gly Thr Thr Thr Thr  Cys Ala Cys 
    1745                 1750                 1755             


Thr Ala  Gly Ala Ala Thr Ala  Ala Thr Gly Gly Cys  Ala Ala Ala 
    1760                 1765                 1770             


Thr Ala  Cys Thr Thr Cys Thr  Ala Ala Thr Thr Thr  Thr Thr Thr 
    1775                 1780                 1785             


Thr Cys  Cys Cys Thr Ala Ala  Ala Cys Ala Thr Thr  Thr Thr Thr 
    1790                 1795                 1800             


Ala Ala  Ala Ala Gly Thr Gly  Ala Ala Ala Thr Ala  Thr Gly Gly 
    1805                 1810                 1815             


Gly Ala  Ala Gly Ala Gly Cys  Thr Thr Thr Ala Cys  Ala Gly Ala 
    1820                 1825                 1830             


Cys Ala  Thr Thr Cys Ala Cys  Cys Ala Ala Cys Thr  Ala Thr Thr 
    1835                 1840                 1845             


Ala Thr  Thr Thr Thr Cys Cys  Cys Thr Thr Gly Thr  Thr Thr Ala 
    1850                 1855                 1860             


Thr Cys  Thr Ala Cys Thr Thr  Ala Gly Ala Thr Ala  Thr Cys Thr 
    1865                 1870                 1875             


Gly Thr  Thr Thr Ala Ala Thr  Cys Thr Thr Ala Cys  Thr Ala Ala 
    1880                 1885                 1890             


Gly Ala  Ala Ala Ala Cys Thr  Thr Thr Cys Gly Cys  Cys Thr Cys 
    1895                 1900                 1905             


Ala Thr  Thr Ala Cys Ala Thr  Thr Ala Ala Ala Ala  Ala Gly Gly 
    1910                 1915                 1920             


Ala Ala  Thr Thr Thr Thr Ala  Gly Ala Gly Ala Thr  Thr Gly Ala 
    1925                 1930                 1935             


Thr Thr  Gly Thr Thr Thr Thr  Ala Ala Ala Ala Ala  Ala Ala Ala 
    1940                 1945                 1950             


Ala Thr  Ala Cys Gly Cys Ala  Cys Ala Thr Thr Gly  Thr Cys Cys 
    1955                 1960                 1965             


Ala Ala  Thr Cys Cys Ala Gly  Thr Gly Ala Thr Thr  Thr Thr Ala 
    1970                 1975                 1980             


Ala Thr  Cys Ala Thr Ala Cys  Ala Gly Thr Thr Thr  Gly Ala Cys 
    1985                 1990                 1995             


Thr Gly  Gly Gly Cys Ala Ala  Ala Cys Thr Thr Thr  Ala Cys Ala 
    2000                 2005                 2010             


Gly Cys  Thr Gly Ala Thr Ala  Gly Thr Gly Ala Ala  Thr Ala Thr 
    2015                 2020                 2025             


Thr Thr  Thr Gly Cys Thr Thr  Thr Ala Thr Ala Cys  Ala Gly Gly 
    2030                 2035                 2040             


Ala Ala  Thr Thr Gly Ala Cys  Ala Cys Thr Gly Ala  Thr Thr Thr 
    2045                 2050                 2055             


Gly Gly  Ala Thr Thr Thr Gly  Thr Gly Cys Ala Cys  Thr Cys Thr 
    2060                 2065                 2070             


Ala Ala  Thr Thr Thr Thr Thr  Ala Ala Cys Thr Thr  Ala Thr Thr 
    2075                 2080                 2085             


Gly Ala  Thr Gly Cys Thr Cys  Thr Ala Thr Thr Gly  Thr Gly Cys 
    2090                 2095                 2100             


Ala Gly  Thr Ala Gly Cys Ala  Thr Thr Thr Cys Ala  Thr Thr Thr 
    2105                 2110                 2115             


Ala Ala  Gly Ala Thr Ala Ala  Gly Gly Cys Thr Cys  Ala Thr Ala 
    2120                 2125                 2130             


Thr Ala  Gly Thr Ala Thr Thr  Ala Cys Cys Cys Ala  Ala Cys Thr 
    2135                 2140                 2145             


Ala Gly  Thr Thr Gly Gly Thr  Ala Ala Thr Gly Thr  Gly Ala Thr 
    2150                 2155                 2160             


Thr Ala  Thr Gly Thr Gly Gly  Thr Ala Cys Cys Thr  Thr Gly Gly 
    2165                 2170                 2175             


Cys Thr  Thr Thr Ala Gly Gly  Thr Thr Thr Thr Cys  Ala Thr Thr 
    2180                 2185                 2190             


Cys Gly  Cys Ala Cys Gly Gly  Ala Ala Cys Ala Cys  Cys Thr Thr 
    2195                 2200                 2205             


Thr Thr  Gly Gly Cys Ala Thr  Gly Cys Thr Thr Ala  Ala Cys Thr 
    2210                 2215                 2220             


Thr Cys  Cys Thr Gly Gly Thr  Ala Ala Cys Ala Cys  Cys Thr Thr 
    2225                 2230                 2235             


Cys Ala  Cys Cys Thr Gly Cys  Ala Thr Thr Gly Gly  Thr Thr Thr 
    2240                 2245                 2250             


Thr Cys  Thr Thr Thr Thr Thr  Cys Thr Thr Thr Thr  Thr Thr Cys 
    2255                 2260                 2265             


Thr Thr  Thr Cys Thr Thr Thr  Thr Thr Thr Thr Thr  Thr Thr Thr 
    2270                 2275                 2280             


Thr Thr  Thr Thr Thr Thr Thr  Thr Thr Thr Thr Thr  Gly Ala Gly 
    2285                 2290                 2295             


Thr Thr  Gly Thr Thr Gly Thr  Thr Thr Gly Thr Thr  Thr Thr Thr 
    2300                 2305                 2310             


Ala Gly  Ala Thr Cys Cys Ala  Cys Ala Gly Thr Ala  Cys Ala Thr 
    2315                 2320                 2325             


Gly Ala  Gly Ala Ala Thr Cys  Cys Thr Thr Thr Thr  Thr Thr Gly 
    2330                 2335                 2340             


Ala Cys  Ala Ala Gly Cys Cys  Thr Thr Gly Gly Ala  Ala Ala Gly 
    2345                 2350                 2355             


Cys Thr  Gly Ala Cys Ala Cys  Thr Gly Thr Cys Thr  Cys Thr Thr 
    2360                 2365                 2370             


Thr Thr  Thr Cys Cys Thr Cys  Cys Cys Thr Cys Thr  Ala Thr Ala 
    2375                 2380                 2385             


Cys Gly  Ala Ala Gly Gly Ala  Thr Gly Thr Ala Thr  Thr Thr Ala 
    2390                 2395                 2400             


Ala Ala  Thr Gly Ala Ala Thr  Gly Cys Thr Gly Gly  Thr Cys Ala 
    2405                 2410                 2415             


Gly Thr  Gly Gly Gly Ala Cys  Ala Thr Thr Thr Thr  Gly Thr Cys 
    2420                 2425                 2430             


Ala Ala  Cys Thr Ala Thr Gly  Gly Gly Thr Ala Thr  Thr Gly Gly 
    2435                 2440                 2445             


Gly Thr  Gly Cys Thr Thr Ala  Ala Cys Thr Gly Thr  Cys Thr Ala 
    2450                 2455                 2460             


Ala Thr  Ala Thr Thr Gly Cys  Cys Ala Thr Gly Thr  Gly Ala Ala 
    2465                 2470                 2475             


Thr Gly  Thr Thr Gly Thr Ala  Thr Ala Cys Gly Ala  Thr Thr Gly 
    2480                 2485                 2490             


Thr Ala  Ala Gly Gly Cys Thr  Thr Ala Thr Gly Thr  Cys Ala Cys 
    2495                 2500                 2505             


Thr Ala  Ala Ala Gly Ala Thr  Thr Thr Thr Thr Ala  Thr Thr Cys 
    2510                 2515                 2520             


Thr Gly  Ala Thr Thr Thr Thr  Thr Thr Cys Ala Thr  Ala Ala Thr 
    2525                 2530                 2535             


Cys Ala  Ala Ala Gly Gly Thr  Cys Ala Thr Ala Thr  Gly Ala Thr 
    2540                 2545                 2550             


Ala Cys  Thr Gly Thr Ala Thr  Ala Gly Ala Cys Ala  Ala Gly Cys 
    2555                 2560                 2565             


Thr Thr  Thr Gly Thr Ala Gly  Thr Gly Ala Ala Gly  Thr Ala Thr 
    2570                 2575                 2580             


Ala Gly  Thr Ala Gly Cys Ala  Ala Thr Ala Ala Thr  Thr Thr Cys 
    2585                 2590                 2595             


Thr Gly  Thr Ala Cys Cys Thr  Gly Ala Thr Cys Ala  Ala Gly Thr 
    2600                 2605                 2610             


Thr Thr  Ala Thr Thr Gly Cys  Ala Gly Cys Cys Thr  Thr Thr Cys 
    2615                 2620                 2625             


Thr Thr  Thr Thr Cys Cys Thr  Ala Thr Thr Thr Cys  Thr Thr Thr 
    2630                 2635                 2640             


Thr Thr  Thr Thr Thr Ala Ala  Gly Gly Gly Thr Thr  Ala Gly Thr 
    2645                 2650                 2655             


Ala Thr  Thr Ala Ala Cys Ala  Ala Ala Thr Gly Gly  Cys Ala Ala 
    2660                 2665                 2670             


Thr Gly  Ala Gly Thr Ala Gly  Ala Ala Ala Ala Gly  Thr Thr Ala 
    2675                 2680                 2685             


Ala Cys  Ala Thr Gly Ala Ala  Gly Ala Thr Thr Thr  Thr Ala Gly 
    2690                 2695                 2700             


Ala Ala  Gly Gly Ala Gly Ala  Gly Ala Ala Cys Thr  Thr Ala Cys 
    2705                 2710                 2715             


Ala Gly  Gly Ala Cys Ala Cys  Ala Gly Ala Thr Thr  Thr Gly Thr 
    2720                 2725                 2730             


Gly Ala  Thr Thr Cys Thr Thr  Thr Gly Ala Cys Thr  Gly Thr Gly 
    2735                 2740                 2745             


Ala Cys  Ala Cys Thr Ala Thr  Thr Gly Gly Ala Thr  Gly Thr Gly 
    2750                 2755                 2760             


Ala Thr  Thr Cys Thr Ala Ala  Ala Ala Gly Cys Thr  Thr Thr Thr 
    2765                 2770                 2775             


Ala Thr  Thr Gly Ala Gly Cys  Ala Thr Thr Gly Thr  Cys Ala Ala 
    2780                 2785                 2790             


Ala Thr  Thr Thr Gly Thr Ala  Ala Gly Cys Thr Thr  Cys Ala Thr 
    2795                 2800                 2805             


Ala Gly  Gly Gly Ala Thr Gly  Gly Ala Cys Ala Thr  Cys Ala Thr 
    2810                 2815                 2820             


Ala Thr  Cys Thr Ala Thr Ala  Ala Thr Gly Cys Cys  Cys Thr Thr 
    2825                 2830                 2835             


Cys Thr  Ala Thr Ala Thr Gly  Thr Gly Cys Thr Ala  Cys Cys Ala 
    2840                 2845                 2850             


Thr Ala  Gly Ala Thr Gly Thr  Gly Ala Cys Ala Thr  Thr Thr Thr 
    2855                 2860                 2865             


Thr Gly  Ala Cys Cys Thr Thr  Ala Ala Thr Ala Thr  Cys Gly Thr 
    2870                 2875                 2880             


Cys Thr  Thr Thr Gly Ala Ala  Ala Ala Thr Gly Thr  Thr Ala Ala 
    2885                 2890                 2895             


Ala Thr  Thr Gly Ala Gly Ala  Ala Ala Cys Cys Thr  Gly Thr Thr 
    2900                 2905                 2910             


Ala Ala  Cys Thr Thr Ala Cys  Ala Thr Thr Thr Thr  Ala Thr Gly 
    2915                 2920                 2925             


Ala Ala  Thr Thr Gly Gly Cys  Ala Cys Ala Thr Thr  Gly Thr Ala 
    2930                 2935                 2940             


Thr Thr  Ala Cys Thr Thr Ala  Cys Thr Gly Cys Ala  Ala Gly Ala 
    2945                 2950                 2955             


Gly Ala  Thr Ala Thr Thr Thr  Cys Ala Thr Thr Thr  Thr Cys Ala 
    2960                 2965                 2970             


Gly Cys  Ala Cys Ala Gly Thr  Gly Cys Ala Ala Ala  Ala Gly Thr 
    2975                 2980                 2985             


Thr Cys  Thr Thr Thr Ala Ala  Ala Ala Thr Gly Cys  Ala Thr Ala 
    2990                 2995                 3000             


Thr Gly  Thr Cys Thr Thr Thr  Thr Thr Thr Thr Cys  Thr Ala Ala 
    3005                 3010                 3015             


Thr Thr  Cys Cys Gly Thr Thr  Thr Thr Gly Thr Thr  Thr Thr Ala 
    3020                 3025                 3030             


Ala Ala  Gly Cys Ala Cys Ala  Thr Thr Thr Thr Ala  Ala Ala Thr 
    3035                 3040                 3045             


Gly Thr  Ala Gly Thr Thr Thr  Thr Cys Thr Cys Ala  Thr Thr Thr 
    3050                 3055                 3060             


Ala Gly  Thr Ala Ala Ala Ala  Gly Thr Thr Gly Thr  Cys Thr Ala 
    3065                 3070                 3075             


Ala Thr  Thr Gly Ala Thr Ala  Thr Gly Ala Ala Gly  Cys Cys Thr 
    3080                 3085                 3090             


Gly Ala  Cys Thr Gly Ala Thr  Thr Thr Thr Thr Thr  Thr Thr Thr 
    3095                 3100                 3105             


Thr Cys  Cys Thr Thr Ala Cys  Ala Gly Thr Gly Ala  Gly Ala Cys 
    3110                 3115                 3120             


Ala Thr  Thr Thr Ala Ala Gly  Cys Ala Cys Ala Cys  Ala Thr Thr 
    3125                 3130                 3135             


Thr Thr  Ala Thr Thr Cys Ala  Cys Ala Thr Ala Gly  Ala Thr Ala 
    3140                 3145                 3150             


Cys Thr  Ala Thr Gly Thr Cys  Cys Thr Thr Gly Ala  Cys Ala Thr 
    3155                 3160                 3165             


Ala Thr  Thr Gly Ala Ala Ala  Thr Gly Ala Thr Thr  Cys Thr Thr 
    3170                 3175                 3180             


Thr Thr  Cys Thr Gly Ala Ala  Ala Gly Thr Ala Thr  Thr Cys Ala 
    3185                 3190                 3195             


Thr Gly  Ala Thr Cys Thr Gly  Cys Ala Thr Ala Thr  Gly Ala Thr 
    3200                 3205                 3210             


Gly Thr  Ala Thr Thr Ala Gly  Gly Thr Thr Ala Gly  Gly Thr Cys 
    3215                 3220                 3225             


Ala Cys  Ala Ala Ala Gly Gly  Thr Thr Thr Thr Ala  Thr Cys Thr 
    3230                 3235                 3240             


Gly Ala  Gly Gly Thr Gly Ala  Thr Thr Thr Ala Ala  Ala Thr Ala 
    3245                 3250                 3255             


Ala Cys  Thr Thr Cys Cys Thr  Gly Ala Thr Thr Gly  Gly Ala Gly 
    3260                 3265                 3270             


Thr Gly  Thr Gly Thr Ala Ala  Gly Cys Thr Gly Ala  Gly Cys Gly 
    3275                 3280                 3285             


Ala Thr  Thr Thr Cys Thr Ala  Ala Thr Ala Ala Ala  Ala Thr Thr 
    3290                 3295                 3300             


Thr Thr  Ala Gly Thr Thr Gly  Thr Ala Cys Ala Cys  Thr Thr Thr 
    3305                 3310                 3315             


Thr Ala  Gly Thr Ala Gly Thr  Cys Ala Thr Ala Gly  Thr Gly Ala 
    3320                 3325                 3330             


Ala Gly  Cys Ala Gly Gly Thr  Cys Thr Ala Gly Ala  Ala Ala Ala 
    3335                 3340                 3345             


Thr Ala  Ala Gly Cys Cys Thr  Thr Thr Gly Gly Cys  Ala Gly Gly 
    3350                 3355                 3360             


Gly Ala  Ala Ala Ala Ala Gly  Gly Gly Cys Ala Ala  Thr Gly Thr 
    3365                 3370                 3375             


Thr Gly  Ala Thr Thr Ala Ala  Thr Cys Thr Cys Ala  Gly Thr Ala 
    3380                 3385                 3390             


Thr Thr  Ala Ala Ala Cys Cys  Ala Cys Ala Thr Thr  Ala Ala Thr 
    3395                 3400                 3405             


Cys Thr  Gly Thr Ala Thr Cys  Cys Cys Ala Thr Thr  Gly Thr Cys 
    3410                 3415                 3420             


Thr Gly  Gly Cys Thr Thr Thr  Thr Gly Thr Ala Ala  Ala Thr Thr 
    3425                 3430                 3435             


Cys Ala  Thr Cys Cys Ala Gly  Gly Thr Cys Ala Ala  Gly Ala Cys 
    3440                 3445                 3450             


Thr Ala  Ala Gly Thr Ala Thr  Gly Thr Thr Gly Gly  Thr Thr Ala 
    3455                 3460                 3465             


Ala Thr  Ala Gly Gly Ala Ala  Thr Cys Cys Thr Thr  Thr Thr Thr 
    3470                 3475                 3480             


Thr Thr  Thr Thr Thr Thr Thr  Thr Thr Ala Ala Ala  Gly Ala Cys 
    3485                 3490                 3495             


Thr Ala  Ala Ala Thr Gly Thr  Gly Ala Ala Ala Ala  Ala Ala Thr 
    3500                 3505                 3510             


Ala Ala  Thr Cys Ala Cys Thr  Ala Cys Thr Thr Ala  Ala Gly Cys 
    3515                 3520                 3525             


Thr Ala  Ala Thr Thr Ala Ala  Thr Ala Thr Thr Gly  Gly Thr Cys 
    3530                 3535                 3540             


Ala Thr  Thr Ala Ala Ala Thr  Thr Thr Ala Ala Ala  Gly Gly Ala 
    3545                 3550                 3555             


Thr Gly  Gly Ala Ala Ala Thr  Thr Thr Ala Thr Cys  Ala Thr Gly 
    3560                 3565                 3570             


Thr Thr  Thr Ala Ala Ala Ala  Ala Thr Thr Ala Thr  Thr Cys Ala 
    3575                 3580                 3585             


Ala Gly  Cys Ala Cys Thr Cys  Thr Thr Ala Ala Ala  Ala Cys Cys 
    3590                 3595                 3600             


Ala Cys  Thr Thr Ala Ala Ala  Cys Ala Gly Cys Cys  Thr Cys Cys 
    3605                 3610                 3615             


Ala Gly  Thr Cys Ala Thr Ala  Ala Ala Ala Ala Thr  Gly Thr Gly 
    3620                 3625                 3630             


Thr Thr  Cys Thr Thr Thr Ala  Cys Ala Ala Ala Thr  Ala Thr Thr 
    3635                 3640                 3645             


Thr Gly  Cys Thr Thr Gly Gly  Cys Ala Ala Cys Ala  Cys Gly Ala 
    3650                 3655                 3660             


Cys Thr  Thr Gly Ala Ala Ala  Thr Ala Ala Ala Thr  Ala Ala Ala 
    3665                 3670                 3675             


Ala Cys  Thr Thr Thr Gly Thr  Thr Thr Cys Thr Thr  Ala Gly Gly 
    3680                 3685                 3690             


Ala Gly  Ala Ala Ala Ala Thr  Gly Ala Thr Thr Cys  Thr Gly Thr 
    3695                 3700                 3705             


Ala Ala  Thr Thr Cys Cys Ala  Gly Thr Gly Thr Cys  Ala Cys Thr 
    3710                 3715                 3720             


Ala Ala  Thr Thr Thr Ala Thr  Ala Thr Thr Gly Thr  Thr Cys Thr 
    3725                 3730                 3735             


Thr Thr  Cys Cys Thr Cys Thr  Gly Ala Thr Thr Thr  Thr Thr Thr 
    3740                 3745                 3750             


Thr Cys  Ala Gly Gly Thr Thr  Ala Gly Thr Gly Ala  Thr Thr Thr 
    3755                 3760                 3765             


Thr Thr  Thr Thr Gly Thr Ala  Thr Ala Cys Ala Ala  Thr Thr Thr 
    3770                 3775                 3780             


Ala Ala  Thr Cys Cys Ala Ala  Ala Thr Gly Thr Thr  Ala Thr Gly 
    3785                 3790                 3795             


Ala Cys  Ala Thr Thr Cys Ala  Gly Ala Ala Ala Thr  Cys Ala Thr 
    3800                 3805                 3810             


Gly Ala  Ala Ala Cys Ala Cys  Ala Gly Thr Ala Gly  Ala Thr Ala 
    3815                 3820                 3825             


Thr Cys  Thr Gly Thr Thr Ala  Thr Ala Ala Thr Gly  Thr Gly Gly 
    3830                 3835                 3840             


Thr Gly  Thr Ala Thr Cys Ala  Cys Ala Thr Gly Gly  Ala Thr Thr 
    3845                 3850                 3855             


Ala Thr  Ala Ala Ala Gly Cys  Ala Ala Ala Gly Thr  Thr Ala Thr 
    3860                 3865                 3870             


Gly Gly  Thr Cys Gly Ala Thr  Thr Thr Cys Thr Ala  Thr Thr Cys 
    3875                 3880                 3885             


Thr Thr  Gly Ala Ala Ala Gly  Ala Ala Thr Cys Ala  Ala Cys Thr 
    3890                 3895                 3900             


Ala Cys  Ala Gly Thr Gly Ala  Ala Thr Cys Cys Thr  Thr Thr Gly 
    3905                 3910                 3915             


Cys Ala  Thr Thr Thr Gly Ala  Ala Gly Cys Cys Thr  Thr Ala Ala 
    3920                 3925                 3930             


Cys Ala  Thr Gly Cys Ala Thr  Thr Gly Cys Thr Thr  Thr Ala Ala 
    3935                 3940                 3945             


Thr Thr  Thr Thr Gly Cys Cys  Cys Ala Gly Gly Gly  Ala Cys Ala 
    3950                 3955                 3960             


Ala Ala  Thr Thr Thr Thr Ala  Ala Thr Ala Ala Thr  Cys Ala Gly 
    3965                 3970                 3975             


Cys Ala  Ala Gly Ala Cys Thr  Gly Gly Thr Thr Thr  Gly Thr Gly 
    3980                 3985                 3990             


Cys Ala  Ala Ala Gly Cys Gly  Thr Thr Gly Ala Gly  Thr Cys Ala 
    3995                 4000                 4005             


Thr Cys  Ala Gly Gly Thr Ala  Thr Thr Thr Ala Gly  Ala Gly Cys 
    4010                 4015                 4020             


Cys Thr  Ala Gly Cys Cys Ala  Gly Cys Thr Ala Cys  Cys Cys Ala 
    4025                 4030                 4035             


Gly Thr  Ala Thr Cys Cys Ala  Thr Gly Cys Thr Gly  Cys Cys Ala 
    4040                 4045                 4050             


Thr Ala  Thr Cys Cys Cys Thr  Thr Cys Ala Thr Thr  Gly Thr Ala 
    4055                 4060                 4065             


Ala Ala  Ala Ala Gly Thr Ala  Cys Cys Thr Ala Ala  Ala Cys Ala 
    4070                 4075                 4080             


Thr Thr  Cys Gly Thr Gly Ala  Ala Ala Thr Gly Ala  Thr Thr Thr 
    4085                 4090                 4095             


Thr Thr  Thr Thr Thr Ala Gly  Cys Thr Gly Ala Ala  Ala Ala Ala 
    4100                 4105                 4110             


Thr Gly  Cys Thr Gly Gly Cys  Ala Ala Gly Ala Ala  Gly Ala Ala 
    4115                 4120                 4125             


Thr Thr  Thr Thr Ala Ala Ala  Gly Cys Thr Thr Ala  Ala Ala Ala 
    4130                 4135                 4140             


Thr Ala  Gly Gly Thr Gly Gly  Thr Ala Ala Ala Thr  Thr Thr Gly 
    4145                 4150                 4155             


Ala Ala  Gly Thr Ala Thr Gly  Ala Gly Thr Gly Thr  Gly Thr Thr 
    4160                 4165                 4170             


Cys Ala  Cys Gly Ala Gly Ala  Ala Ala Cys Ala Thr  Ala Gly Gly 
    4175                 4180                 4185             


Cys Thr  Thr Thr Thr Cys Ala  Ala Ala Ala Ala Ala  Ala Thr Thr 
    4190                 4195                 4200             


Thr Thr  Thr Ala Thr Thr Cys  Ala Ala Gly Gly Cys  Ala Ala Ala 
    4205                 4210                 4215             


Gly Cys  Ala Ala Gly Gly Ala  Ala Cys Ala Thr Cys  Thr Thr Gly 
    4220                 4225                 4230             


Ala Gly  Ala Thr Ala Thr Gly  Thr Cys Thr Cys Ala  Ala Gly Ala 
    4235                 4240                 4245             


Ala Thr  Ala Thr Ala Ala Ala  Gly Ala Thr Gly Thr  Ala Thr Thr 
    4250                 4255                 4260             


Ala Thr  Thr Thr Thr Ala Ala  Gly Cys Cys Ala Ala  Gly Gly Ala 
    4265                 4270                 4275             


Gly Cys  Thr Gly Ala Ala Ala  Thr Ala Thr Ala Thr  Cys Thr Cys 
    4280                 4285                 4290             


Ala Gly  Thr Thr Thr Ala Thr  Ala Ala Ala Thr Thr  Cys Ala Gly 
    4295                 4300                 4305             


Gly Thr  Ala Thr Ala Thr Thr  Cys Thr Thr Thr Thr  Thr Gly Thr 
    4310                 4315                 4320             


Cys Thr  Cys Cys Ala Thr Gly  Gly Cys Ala Ala Cys  Cys Ala Thr 
    4325                 4330                 4335             


Ala Ala  Cys Thr Thr Thr Thr  Gly Ala Ala Cys Cys  Ala Ala Ala 
    4340                 4345                 4350             


Ala Ala  Ala Ala Ala Thr Thr  Gly Thr Thr Thr Thr  Thr Ala Cys 
    4355                 4360                 4365             


Ala Thr  Cys Thr Thr Thr Ala  Thr Gly Cys Thr Gly  Ala Ala Ala 
    4370                 4375                 4380             


Ala Thr  Gly Thr Gly Thr Thr  Thr Ala Gly Ala Thr  Thr Ala Gly 
    4385                 4390                 4395             


Gly Ala  Ala Thr Ala Thr Gly  Gly Thr Cys Gly Gly  Gly Cys Thr 
    4400                 4405                 4410             


Gly Ala  Ala Thr Thr Thr Gly  Cys Thr Gly Thr Thr  Gly Cys Thr 
    4415                 4420                 4425             


Cys Cys  Cys Thr Ala Ala Cys  Cys Ala Ala Ala Thr  Cys Cys Ala 
    4430                 4435                 4440             


Cys Cys  Thr Cys Thr Thr Gly  Thr Thr Thr Thr Cys  Cys Thr Thr 
    4445                 4450                 4455             


Gly Thr  Gly Ala Gly Thr Cys  Cys Ala Thr Gly Gly  Cys Thr Ala 
    4460                 4465                 4470             


Ala Ala  Thr Cys Ala Ala Ala  Gly Cys Thr Gly Cys  Cys Cys Cys 
    4475                 4480                 4485             


Thr Gly  Ala Gly Ala Ala Gly  Ala Gly Ala Cys Thr  Thr Ala Ala 
    4490                 4495                 4500             


Thr Cys  Cys Ala Ala Gly Cys  Cys Thr Gly Ala Thr  Thr Gly Thr 
    4505                 4510                 4515             


Ala Cys  Thr Ala Gly Thr Gly  Gly Cys Ala Thr Cys  Ala Cys Thr 
    4520                 4525                 4530             


Thr Ala  Gly Ala Ala Gly Thr  Ala Gly Gly Cys Thr  Thr Thr Cys 
    4535                 4540                 4545             


Cys Cys  Thr Cys Thr Thr Cys  Cys Thr Ala Gly Thr  Ala Gly Ala 
    4550                 4555                 4560             


Thr Cys  Thr Cys Ala Ala Thr  Gly Thr Thr Thr Thr  Ala Thr Ala 
    4565                 4570                 4575             


Ala Thr  Thr Cys Cys Thr Thr  Ala Ala Ala Ala Cys  Ala Gly Cys 
    4580                 4585                 4590             


Thr Gly  Ala Ala Ala Ala Thr  Thr Gly Gly Gly Ala  Cys Ala Ala 
    4595                 4600                 4605             


Cys Ala  Thr Ala Cys Thr Thr  Thr Ala Cys Gly Cys  Ala Ala Thr 
    4610                 4615                 4620             


Gly Ala  Ala Cys Ala Gly Thr  Ala Gly Thr Thr Ala  Ala Ala Thr 
    4625                 4630                 4635             


Ala Gly  Gly Ala Ala Ala Thr  Ala Ala Ala Cys Thr  Ala Gly Thr 
    4640                 4645                 4650             


Thr Cys  Cys Ala Thr Ala Thr  Ala Ala Gly Thr Ala  Thr Ala Cys 
    4655                 4660                 4665             


Ala Cys  Cys Thr Ala Gly Ala  Gly Thr Thr Thr Thr  Ala Ala Thr 
    4670                 4675                 4680             


Thr Ala  Cys Cys Thr Thr Thr  Ala Thr Ala Ala Thr  Gly Thr Thr 
    4685                 4690                 4695             


Thr Cys  Thr Thr Ala Ala Ala  Ala Gly Thr Gly Ala  Ala Ala Cys 
    4700                 4705                 4710             


Thr Thr  Ala Gly Ala Thr Ala  Cys Ala Ala Thr Thr  Gly Thr Gly 
    4715                 4720                 4725             


Ala Thr  Thr Gly Gly Ala Thr  Ala Cys Thr Thr Ala  Gly Ala Thr 
    4730                 4735                 4740             


Ala Cys  Thr Ala Ala Gly Thr  Gly Ala Ala Ala Cys  Thr Thr Ala 
    4745                 4750                 4755             


Gly Thr  Gly Thr Ala Ala Cys  Ala Ala Thr Thr Thr  Thr Gly Ala 
    4760                 4765                 4770             


Thr Cys  Thr Gly Thr Thr Ala  Ala Ala Thr Thr Gly  Gly Ala Thr 
    4775                 4780                 4785             


Thr Thr  Thr Ala Cys Ala Thr  Gly Thr Ala Cys Ala  Thr Thr Thr 
    4790                 4795                 4800             


Gly Ala  Ala Thr Gly Cys Cys  Ala Gly Ala Ala Thr  Thr Thr Cys 
    4805                 4810                 4815             


Thr Ala  Ala Ala Thr Ala Ala  Ala Thr Cys Cys Cys  Cys Thr Gly 
    4820                 4825                 4830             


Gly Thr  Thr Ala Gly Gly Ala  Ala Ala Thr Thr Thr  Thr Ala Ala 
    4835                 4840                 4845             


Ala Ala  Gly Thr Cys Ala Ala  Ala Gly Cys Thr Thr  Gly Thr Thr 
    4850                 4855                 4860             


Thr Thr  Cys Thr Thr Cys Ala  Ala Cys Cys Ala Cys  Thr Ala Cys 
    4865                 4870                 4875             


Cys Thr  Thr Cys Thr Ala Cys  Ala Thr Thr Gly Gly  Thr Thr Gly 
    4880                 4885                 4890             


Ala Cys  Thr Thr Ala Gly Ala  Cys Cys Gly Thr Ala  Ala Gly Cys 
    4895                 4900                 4905             


Thr Thr  Thr Thr Thr Ala Ala  Gly Thr Thr Thr Cys  Thr Cys Ala 
    4910                 4915                 4920             


Thr Thr  Gly Thr Ala Ala Thr  Thr Thr Ala Cys Cys  Thr Thr Cys 
    4925                 4930                 4935             


Thr Cys  Ala Thr Gly Cys Ala  Gly Ala Thr Thr Gly  Cys Thr Gly 
    4940                 4945                 4950             


Ala Thr  Gly Thr Thr Thr Thr  Ala Thr Thr Ala Ala  Ala Cys Cys 
    4955                 4960                 4965             


Thr Thr  Ala Thr Thr Thr Thr  Thr Ala Cys Ala Ala  Ala Ala Ala 
    4970                 4975                 4980             


Thr Gly  Ala Ala Ala Ala Ala  Ala 
    4985                 4990     


<210>  15
<211>  4024
<212>  PRT
<213>  Mus musculus protein phosphatase 1, catalytic subunit, beta isoform (Ppp1cb), mRNA

<400>  15

Gly Cys Gly Gly Cys Thr Ala Gly Gly Cys Gly Gly Cys Cys Cys Gly 
1               5                   10                  15      


Cys Ala Ala Gly Gly Gly Cys Gly Gly Ala Gly Gly Gly Gly Ala Gly 
            20                  25                  30          


Gly Gly Ala Gly Thr Gly Ala Cys Gly Cys Thr Gly Ala Gly Gly Gly 
        35                  40                  45              


Cys Gly Gly Gly Gly Cys Thr Gly Thr Cys Cys Gly Thr Gly Gly Cys 
    50                  55                  60                  


Gly Cys Thr Gly Cys Cys Gly Ala Gly Cys Thr Thr Thr Gly Cys Gly 
65                  70                  75                  80  


Gly Ala Gly Cys Thr Gly Gly Gly Cys Gly Gly Thr Gly Cys Cys Gly 
                85                  90                  95      


Ala Gly Gly Ala Gly Gly Ala Gly Gly Thr Gly Gly Ala Gly Gly Ala 
            100                 105                 110         


Gly Gly Cys Gly Gly Thr Gly Gly Cys Gly Gly Cys Thr Gly Gly Gly 
        115                 120                 125             


Gly Thr Cys Thr Gly Ala Cys Gly Cys Gly Gly Cys Cys Cys Gly Gly 
    130                 135                 140                 


Thr Thr Cys Cys Thr Gly Ala Cys Gly Cys Gly Gly Cys Cys Cys Gly 
145                 150                 155                 160 


Gly Thr Thr Cys Cys Thr Gly Gly Gly Gly Gly Cys Cys Thr Gly Cys 
                165                 170                 175     


Thr Thr Gly Thr Thr Thr Ala Thr Thr Thr Ala Thr Thr Thr Ala Thr 
            180                 185                 190         


Thr Thr Cys Cys Ala Gly Thr Gly Gly Gly Cys Gly Cys Cys Gly Cys 
        195                 200                 205             


Cys Ala Gly Cys Gly Thr Gly Thr Gly Cys Gly Cys Gly Cys Gly Cys 
    210                 215                 220                 


Thr Gly Thr Cys Gly Cys Thr Gly Cys Thr Cys Gly Gly Cys Gly Gly 
225                 230                 235                 240 


Gly Gly Ala Gly Gly Gly Gly Gly Thr Gly Gly Gly Gly Gly Gly Ala 
                245                 250                 255     


Gly Gly Gly Cys Cys Cys Gly Cys Gly Cys Cys Cys Gly Gly Gly Gly 
            260                 265                 270         


Gly Gly Ala Gly Thr Thr Gly Gly Ala Gly Cys Cys Gly Gly Gly Gly 
        275                 280                 285             


Thr Cys Gly Ala Ala Ala Cys Gly Cys Cys Gly Cys Gly Thr Gly Ala 
    290                 295                 300                 


Cys Thr Cys Gly Thr Ala Gly Gly Thr Gly Ala Gly Ala Ala Cys Gly 
305                 310                 315                 320 


Cys Cys Gly Ala Gly Cys Cys Gly Cys Cys Gly Cys Cys Gly Cys Cys 
                325                 330                 335     


Gly Cys Cys Gly Ala Gly Ala Ala Gly Cys Cys Cys Thr Gly Thr Thr 
            340                 345                 350         


Ala Ala Cys Gly Cys Thr Thr Thr Ala Gly Gly Gly Ala Gly Gly Ala 
        355                 360                 365             


Gly Ala Gly Thr Cys Thr Gly Gly Thr Gly Cys Cys Gly Ala Cys Ala 
    370                 375                 380                 


Ala Gly Ala Thr Gly Gly Cys Gly Gly Ala Cys Gly Gly Gly Gly Ala 
385                 390                 395                 400 


Gly Cys Thr Gly Ala Ala Cys Gly Thr Gly Gly Ala Cys Ala Gly Cys 
                405                 410                 415     


Cys Thr Cys Ala Thr Cys Ala Cys Cys Cys Gly Cys Cys Thr Gly Cys 
            420                 425                 430         


Thr Gly Gly Ala Gly Gly Thr Ala Cys Gly Ala Gly Gly Ala Thr Gly 
        435                 440                 445             


Thr Cys Gly Thr Cys Cys Ala Gly Gly Ala Ala Ala Gly Ala Thr Thr 
    450                 455                 460                 


Gly Thr Ala Cys Ala Ala Ala Thr Gly Ala Cys Thr Gly Ala Ala Gly 
465                 470                 475                 480 


Cys Ala Gly Ala Ala Gly Thr Cys Cys Gly Ala Gly Gly Gly Thr Thr 
                485                 490                 495     


Gly Thr Gly Thr Ala Thr Cys Ala Ala Gly Thr Cys Thr Cys Gly Thr 
            500                 505                 510         


Gly Ala Ala Ala Thr Cys Thr Thr Thr Cys Thr Cys Ala Gly Cys Cys 
        515                 520                 525             


Ala Gly Cys Cys Thr Ala Thr Thr Cys Thr Thr Thr Thr Gly Gly Ala 
    530                 535                 540                 


Ala Thr Thr Gly Gly Ala Ala Gly Cys Ala Cys Cys Ala Cys Thr Gly 
545                 550                 555                 560 


Ala Ala Gly Ala Thr Thr Thr Gly Thr Gly Gly Ala Gly Ala Cys Ala 
                565                 570                 575     


Thr Thr Cys Ala Thr Gly Gly Ala Cys Ala Ala Thr Ala Thr Ala Cys 
            580                 585                 590         


Ala Gly Ala Cys Thr Thr Ala Cys Thr Ala Ala Gly Ala Thr Thr Ala 
        595                 600                 605             


Thr Thr Thr Gly Ala Ala Thr Ala Thr Gly Gly Ala Gly Gly Thr Thr 
    610                 615                 620                 


Thr Thr Cys Cys Ala Cys Cys Ala Gly Ala Ala Gly Cys Cys Ala Ala 
625                 630                 635                 640 


Cys Thr Ala Thr Cys Thr Thr Thr Thr Cys Thr Thr Ala Gly Gly Ala 
                645                 650                 655     


Gly Ala Thr Thr Ala Thr Gly Thr Gly Gly Ala Cys Ala Gly Ala Gly 
            660                 665                 670         


Gly Ala Ala Ala Gly Cys Ala Gly Thr Cys Thr Thr Thr Gly Gly Ala 
        675                 680                 685             


Ala Ala Cys Cys Ala Thr Cys Thr Gly Thr Thr Thr Gly Cys Thr Ala 
    690                 695                 700                 


Thr Thr Gly Gly Cys Thr Thr Ala Cys Ala Ala Ala Ala Thr Cys Ala 
705                 710                 715                 720 


Ala Ala Thr Ala Cys Cys Cys Gly Gly Ala Gly Ala Ala Cys Thr Thr 
                725                 730                 735     


Cys Thr Thr Thr Cys Thr Thr Cys Thr Ala Ala Gly Ala Gly Gly Ala 
            740                 745                 750         


Ala Ala Cys Cys Ala Thr Gly Ala Gly Thr Gly Thr Gly Cys Thr Ala 
        755                 760                 765             


Gly Cys Ala Thr Cys Ala Ala Thr Cys Gly Cys Ala Thr Thr Thr Ala 
    770                 775                 780                 


Thr Gly Gly Ala Thr Thr Cys Thr Ala Cys Gly Ala Thr Gly Ala Gly 
785                 790                 795                 800 


Thr Gly Thr Ala Ala Ala Cys Gly Ala Ala Gly Ala Thr Thr Thr Ala 
                805                 810                 815     


Ala Thr Ala Thr Thr Ala Ala Ala Thr Thr Gly Thr Gly Gly Ala Ala 
            820                 825                 830         


Gly Ala Cys Ala Thr Thr Cys Ala Cys Thr Gly Ala Thr Thr Gly Thr 
        835                 840                 845             


Thr Thr Thr Ala Ala Cys Thr Gly Thr Cys Thr Gly Cys Cys Thr Ala 
    850                 855                 860                 


Thr Ala Gly Cys Thr Gly Cys Thr Ala Thr Thr Gly Thr Thr Gly Ala 
865                 870                 875                 880 


Thr Gly Ala Gly Ala Ala Ala Ala Thr Cys Thr Thr Cys Thr Gly Thr 
                885                 890                 895     


Thr Gly Thr Cys Ala Thr Gly Gly Ala Gly Gly Ala Cys Thr Gly Thr 
            900                 905                 910         


Cys Ala Cys Cys Ala Gly Ala Cys Cys Thr Ala Cys Ala Ala Thr Cys 
        915                 920                 925             


Thr Ala Thr Gly Gly Ala Ala Cys Ala Gly Ala Thr Thr Cys Gly Gly 
    930                 935                 940                 


Ala Gly Ala Ala Thr Thr Ala Thr Gly Ala Gly Ala Cys Cys Cys Ala 
945                 950                 955                 960 


Cys Thr Gly Ala Cys Gly Thr Ala Cys Cys Thr Gly Ala Thr Ala Cys 
                965                 970                 975     


Ala Gly Gly Thr Thr Thr Gly Cys Thr Thr Thr Gly Thr Gly Ala Cys 
            980                 985                 990         


Thr Thr Ala Cys Thr Gly Thr Gly  Gly Thr Cys Cys Gly  Ala Cys Cys 
        995                 1000                 1005             


Cys Ala  Gly Ala Thr Ala Ala  Gly Gly Ala Thr Gly  Thr Gly Cys 
    1010                 1015                 1020             


Ala Ala  Gly Gly Cys Thr Gly  Gly Gly Gly Ala Gly  Ala Ala Ala 
    1025                 1030                 1035             


Ala Thr  Gly Ala Cys Cys Gly  Thr Gly Gly Thr Gly  Thr Thr Thr 
    1040                 1045                 1050             


Cys Thr  Thr Thr Thr Ala Cys  Thr Thr Thr Thr Gly  Gly Ala Gly 
    1055                 1060                 1065             


Cys Thr  Gly Ala Thr Gly Thr  Ala Gly Thr Cys Ala  Gly Thr Ala 
    1070                 1075                 1080             


Ala Ala  Thr Thr Thr Cys Thr  Gly Ala Ala Thr Cys  Gly Thr Cys 
    1085                 1090                 1095             


Ala Thr  Gly Ala Thr Thr Thr  Ala Gly Ala Cys Thr  Thr Gly Ala 
    1100                 1105                 1110             


Thr Thr  Thr Gly Thr Cys Gly  Ala Gly Cys Thr Cys  Ala Thr Cys 
    1115                 1120                 1125             


Ala Gly  Gly Thr Gly Gly Thr  Gly Gly Ala Ala Gly  Ala Cys Gly 
    1130                 1135                 1140             


Gly Ala  Thr Ala Thr Gly Ala  Ala Thr Thr Thr Thr  Thr Thr Gly 
    1145                 1150                 1155             


Cys Thr  Ala Ala Ala Cys Gly  Ala Cys Ala Gly Thr  Thr Gly Gly 
    1160                 1165                 1170             


Thr Ala  Ala Cys Cys Thr Thr  Ala Thr Thr Thr Thr  Cys Thr Gly 
    1175                 1180                 1185             


Cys Cys  Cys Cys Ala Ala Ala  Thr Thr Ala Cys Thr  Gly Thr Gly 
    1190                 1195                 1200             


Gly Cys  Gly Ala Gly Thr Thr  Thr Gly Ala Cys Ala  Ala Thr Gly 
    1205                 1210                 1215             


Cys Thr  Gly Gly Thr Gly Gly  Thr Ala Thr Gly Ala  Thr Gly Ala 
    1220                 1225                 1230             


Gly Thr  Gly Thr Gly Gly Ala  Thr Gly Ala Gly Ala  Cys Thr Thr 
    1235                 1240                 1245             


Thr Gly  Ala Thr Gly Thr Gly  Thr Thr Cys Ala Thr  Thr Cys Cys 
    1250                 1255                 1260             


Ala Gly  Ala Thr Ala Thr Thr  Gly Ala Ala Ala Cys  Cys Ala Thr 
    1265                 1270                 1275             


Cys Thr  Gly Ala Ala Ala Ala  Gly Ala Ala Ala Gly  Cys Thr Ala 
    1280                 1285                 1290             


Ala Gly  Thr Ala Cys Cys Ala  Gly Thr Ala Thr Gly  Gly Thr Gly 
    1295                 1300                 1305             


Gly Gly  Cys Thr Gly Ala Ala  Thr Thr Cys Thr Gly  Gly Ala Cys 
    1310                 1315                 1320             


Gly Thr  Cys Cys Thr Gly Thr  Cys Ala Cys Thr Cys  Cys Gly Cys 
    1325                 1330                 1335             


Cys Thr  Cys Gly Ala Ala Cys  Ala Gly Cys Thr Ala  Ala Thr Cys 
    1340                 1345                 1350             


Cys Ala  Cys Cys Gly Ala Ala  Gly Ala Ala Ala Ala  Gly Gly Thr 
    1355                 1360                 1365             


Gly Ala  Ala Gly Ala Cys Ala  Gly Gly Ala Ala Thr  Thr Cys Thr 
    1370                 1375                 1380             


Ala Gly  Ala Ala Ala Gly Ala  Gly Ala Ala Ala Cys  Cys Ala Thr 
    1385                 1390                 1395             


Cys Ala  Gly Ala Thr Thr Thr  Gly Thr Thr Ala Ala  Gly Gly Ala 
    1400                 1405                 1410             


Cys Ala  Thr Ala Cys Thr Thr  Cys Ala Thr Ala Ala  Thr Ala Thr 
    1415                 1420                 1425             


Ala Thr  Ala Ala Gly Thr Gly  Thr Gly Cys Ala Cys  Thr Gly Thr 
    1430                 1435                 1440             


Ala Ala  Ala Ala Cys Cys Ala  Thr Cys Cys Ala Gly  Cys Cys Ala 
    1445                 1450                 1455             


Thr Thr  Cys Gly Ala Cys Ala  Cys Cys Cys Thr Thr  Thr Ala Thr 
    1460                 1465                 1470             


Gly Ala  Thr Gly Thr Cys Ala  Cys Ala Cys Cys Thr  Thr Thr Ala 
    1475                 1480                 1485             


Ala Cys  Thr Thr Ala Ala Gly  Gly Ala Gly Ala Cys  Gly Gly Thr 
    1490                 1495                 1500             


Ala Ala  Ala Gly Gly Ala Thr  Cys Thr Thr Ala Ala  Ala Thr Thr 
    1505                 1510                 1515             


Thr Thr  Thr Thr Thr Cys Thr  Ala Ala Thr Ala Gly  Ala Ala Ala 
    1520                 1525                 1530             


Gly Ala  Thr Gly Thr Gly Cys  Thr Ala Cys Ala Cys  Thr Gly Thr 
    1535                 1540                 1545             


Ala Thr  Thr Gly Thr Ala Ala  Thr Ala Ala Gly Thr  Ala Thr Ala 
    1550                 1555                 1560             


Cys Thr  Cys Thr Gly Thr Thr  Ala Thr Ala Ala Thr  Ala Thr Thr 
    1565                 1570                 1575             


Cys Ala  Ala Cys Ala Ala Ala  Ala Thr Thr Ala Ala  Ala Thr Cys 
    1580                 1585                 1590             


Cys Ala  Ala Ala Thr Thr Cys  Ala Ala Ala Ala Gly  Thr Ala Thr 
    1595                 1600                 1605             


Cys Cys  Ala Thr Thr Ala Ala  Ala Gly Thr Thr Cys  Thr Ala Thr 
    1610                 1615                 1620             


Cys Thr  Thr Cys Thr Cys Ala  Thr Ala Thr Cys Ala  Cys Ala Gly 
    1625                 1630                 1635             


Thr Thr  Thr Thr Thr Ala Ala  Ala Gly Thr Thr Gly  Ala Ala Ala 
    1640                 1645                 1650             


Ala Gly  Cys Ala Thr Cys Cys  Cys Ala Gly Thr Thr  Ala Ala Ala 
    1655                 1660                 1665             


Cys Thr  Ala Gly Cys Cys Cys  Thr Gly Thr Thr Ala  Gly Thr Gly 
    1670                 1675                 1680             


Ala Cys  Cys Cys Ala Gly Ala  Thr Gly Ala Ala Ala  Gly Cys Ala 
    1685                 1690                 1695             


Thr Gly  Ala Ala Gly Ala Thr  Cys Cys Ala Thr Cys  Thr Gly Thr 
    1700                 1705                 1710             


Gly Thr  Ala Ala Thr Gly Thr  Gly Gly Thr Thr Thr  Thr Ala Gly 
    1715                 1720                 1725             


Thr Gly  Gly Thr Gly Cys Thr  Thr Gly Gly Thr Thr  Gly Thr Thr 
    1730                 1735                 1740             


Thr Cys  Ala Thr Thr Ala Thr  Thr Thr Thr Gly Ala  Gly Cys Thr 
    1745                 1750                 1755             


Thr Gly  Thr Thr Thr Thr Gly  Thr Thr Thr Thr Gly  Thr Thr Thr 
    1760                 1765                 1770             


Gly Thr  Thr Thr Thr Thr Gly  Cys Thr Ala Gly Ala  Ala Thr Ala 
    1775                 1780                 1785             


Ala Thr  Gly Gly Cys Ala Thr  Cys Thr Ala Cys Thr  Thr Thr Thr 
    1790                 1795                 1800             


Cys Cys  Thr Ala Thr Thr Thr  Thr Thr Cys Cys Cys  Thr Ala Ala 
    1805                 1810                 1815             


Ala Cys  Ala Thr Thr Thr Thr  Thr Ala Ala Ala Ala  Gly Thr Gly 
    1820                 1825                 1830             


Ala Ala  Ala Ala Thr Gly Gly  Gly Ala Ala Gly Ala  Gly Cys Thr 
    1835                 1840                 1845             


Thr Thr  Ala Ala Ala Gly Ala  Cys Ala Thr Thr Cys  Ala Cys Cys 
    1850                 1855                 1860             


Ala Ala  Cys Thr Ala Thr Thr  Cys Thr Thr Thr Thr  Cys Cys Thr 
    1865                 1870                 1875             


Thr Thr  Ala Cys Thr Thr Ala  Thr Cys Thr Ala Cys  Thr Thr Ala 
    1880                 1885                 1890             


Ala Gly  Thr Ala Ala Cys Thr  Gly Thr Thr Gly Gly  Ala Thr Cys 
    1895                 1900                 1905             


Thr Thr  Ala Cys Thr Ala Ala  Gly Ala Ala Ala Ala  Cys Thr Thr 
    1910                 1915                 1920             


Ala Cys  Cys Cys Cys Thr Cys  Ala Thr Thr Ala Cys  Ala Gly Thr 
    1925                 1930                 1935             


Ala Ala  Ala Ala Ala Gly Gly  Ala Ala Cys Thr Thr  Thr Ala Gly 
    1940                 1945                 1950             


Ala Gly  Gly Thr Cys Gly Ala  Thr Ala Gly Gly Thr  Thr Thr Thr 
    1955                 1960                 1965             


Ala Ala  Ala Ala Ala Thr Ala  Thr Ala Cys Ala Ala  Ala Cys Thr 
    1970                 1975                 1980             


Ala Thr  Cys Thr Gly Ala Thr  Cys Cys Ala Thr Thr  Gly Ala Thr 
    1985                 1990                 1995             


Thr Thr  Thr Ala Ala Thr Cys  Ala Ala Ala Cys Ala  Gly Thr Thr 
    2000                 2005                 2010             


Thr Gly  Ala Cys Thr Gly Gly  Gly Cys Ala Ala Ala  Cys Thr Thr 
    2015                 2020                 2025             


Thr Gly  Cys Ala Gly Cys Thr  Gly Ala Thr Ala Ala  Thr Gly Ala 
    2030                 2035                 2040             


Gly Thr  Ala Thr Thr Thr Cys  Gly Cys Thr Thr Thr  Thr Thr Ala 
    2045                 2050                 2055             


Cys Ala  Ala Ala Ala Thr Thr  Gly Cys Cys Ala Cys  Thr Gly Ala 
    2060                 2065                 2070             


Thr Thr  Thr Gly Gly Ala Thr  Thr Thr Gly Thr Gly  Cys Ala Cys 
    2075                 2080                 2085             


Thr Cys  Thr Ala Ala Thr Cys  Thr Thr Thr Ala Ala  Thr Thr Thr 
    2090                 2095                 2100             


Ala Thr  Thr Gly Ala Thr Gly  Cys Thr Cys Thr Ala  Thr Thr Gly 
    2105                 2110                 2115             


Thr Gly  Cys Ala Gly Thr Ala  Gly Cys Ala Thr Thr  Thr Cys Ala 
    2120                 2125                 2130             


Thr Thr  Thr Ala Ala Gly Ala  Thr Ala Ala Gly Gly  Cys Thr Cys 
    2135                 2140                 2145             


Ala Thr  Ala Thr Ala Gly Thr  Ala Ala Thr Ala Thr  Cys Cys Ala 
    2150                 2155                 2160             


Ala Ala  Ala Cys Thr Ala Gly  Thr Thr Gly Gly Thr  Ala Ala Thr 
    2165                 2170                 2175             


Gly Thr  Gly Ala Thr Thr Ala  Thr Gly Thr Gly Gly  Thr Ala Cys 
    2180                 2185                 2190             


Thr Thr  Thr Gly Gly Cys Thr  Thr Thr Gly Gly Gly  Thr Thr Cys 
    2195                 2200                 2205             


Thr Ala  Ala Thr Thr Cys Gly  Cys Ala Cys Gly Ala  Ala Ala Cys 
    2210                 2215                 2220             


Ala Cys  Cys Thr Thr Thr Thr  Gly Gly Cys Ala Thr  Gly Cys Thr 
    2225                 2230                 2235             


Thr Ala  Ala Cys Thr Thr Thr  Cys Thr Gly Gly Thr  Ala Thr Thr 
    2240                 2245                 2250             


Ala Cys  Cys Cys Thr Cys Ala  Cys Cys Thr Gly Cys  Ala Thr Thr 
    2255                 2260                 2265             


Gly Gly  Thr Thr Thr Thr Gly  Thr Thr Thr Thr Thr  Thr Gly Gly 
    2270                 2275                 2280             


Gly Gly  Thr Thr Thr Thr Thr  Gly Thr Thr Gly Thr  Thr Thr Gly 
    2285                 2290                 2295             


Thr Thr  Thr Gly Thr Thr Thr  Thr Thr Ala Gly Ala  Thr Thr Cys 
    2300                 2305                 2310             


Ala Cys  Ala Gly Ala Ala Cys  Ala Thr Gly Ala Gly  Ala Ala Thr 
    2315                 2320                 2325             


Cys Cys  Thr Thr Thr Thr Thr  Gly Ala Cys Ala Ala  Gly Cys Cys 
    2330                 2335                 2340             


Thr Thr  Gly Gly Ala Thr Ala  Gly Cys Thr Gly Gly  Cys Thr Cys 
    2345                 2350                 2355             


Thr Cys  Thr Thr Cys Thr Thr  Thr Cys Cys Cys Thr  Cys Thr Cys 
    2360                 2365                 2370             


Thr Cys  Thr Ala Thr Gly Thr  Gly Ala Ala Gly Gly  Ala Thr Gly 
    2375                 2380                 2385             


Thr Ala  Thr Thr Thr Ala Ala  Ala Thr Gly Ala Ala  Cys Gly Cys 
    2390                 2395                 2400             


Thr Gly  Gly Thr Cys Ala Gly  Thr Gly Gly Gly Ala  Cys Ala Thr 
    2405                 2410                 2415             


Thr Thr  Gly Thr Cys Ala Gly  Cys Thr Cys Thr Gly  Ala Ala Thr 
    2420                 2425                 2430             


Ala Thr  Thr Gly Gly Gly Thr  Gly Cys Thr Thr Cys  Ala Cys Thr 
    2435                 2440                 2445             


Ala Ala  Thr Ala Ala Thr Thr  Gly Cys Cys Ala Thr  Gly Thr Gly 
    2450                 2455                 2460             


Ala Ala  Thr Gly Thr Thr Gly  Thr Thr Thr Thr Gly  Ala Cys Thr 
    2465                 2470                 2475             


Gly Thr  Ala Ala Gly Gly Cys  Thr Ala Thr Gly Thr  Cys Ala Cys 
    2480                 2485                 2490             


Thr Ala  Ala Ala Gly Ala Thr  Thr Thr Thr Thr Ala  Cys Thr Cys 
    2495                 2500                 2505             


Thr Gly  Cys Gly Thr Thr Thr  Thr Cys Ala Thr Ala  Ala Thr Cys 
    2510                 2515                 2520             


Ala Ala  Ala Gly Gly Thr Cys  Ala Thr Gly Ala Thr  Gly Thr Gly 
    2525                 2530                 2535             


Thr Ala  Thr Ala Gly Ala Cys  Ala Thr Gly Cys Thr  Thr Thr Gly 
    2540                 2545                 2550             


Thr Ala  Gly Thr Gly Ala Ala  Gly Thr Ala Thr Ala  Gly Thr Ala 
    2555                 2560                 2565             


Gly Cys  Ala Ala Thr Ala Ala  Thr Thr Thr Cys Thr  Gly Thr Ala 
    2570                 2575                 2580             


Thr Gly  Thr Gly Ala Thr Cys  Ala Ala Gly Ala Gly  Thr Thr Thr 
    2585                 2590                 2595             


Ala Thr  Thr Gly Cys Ala Thr  Thr Ala Thr Thr Thr  Cys Thr Thr 
    2600                 2605                 2610             


Thr Cys  Cys Cys Thr Gly Thr  Thr Cys Thr Cys Thr  Thr Thr Thr 
    2615                 2620                 2625             


Thr Thr  Thr Thr Thr Thr Thr  Thr Thr Thr Ala Ala  Gly Gly Gly 
    2630                 2635                 2640             


Thr Thr  Ala Gly Cys Ala Thr  Thr Ala Ala Cys Ala  Ala Ala Thr 
    2645                 2650                 2655             


Gly Thr  Cys Ala Ala Gly Gly  Ala Gly Thr Ala Gly  Cys Ala Ala 
    2660                 2665                 2670             


Ala Gly  Thr Cys Ala Ala Cys  Ala Ala Ala Gly Ala  Thr Thr Thr 
    2675                 2680                 2685             


Thr Ala  Gly Ala Ala Gly Gly  Ala Gly Gly Ala Gly  Gly Ala Ala 
    2690                 2695                 2700             


Cys Thr  Ala Ala Gly Ala Gly  Cys Ala Thr Ala Cys  Ala Cys Ala 
    2705                 2710                 2715             


Gly Ala  Cys Thr Thr Ala Thr  Gly Ala Thr Thr Cys  Thr Thr Thr 
    2720                 2725                 2730             


Gly Gly  Ala Thr Gly Thr Gly  Ala Cys Ala Cys Thr  Thr Ala Thr 
    2735                 2740                 2745             


Thr Gly  Gly Ala Thr Gly Thr  Gly Ala Thr Thr Cys  Thr Ala Ala 
    2750                 2755                 2760             


Ala Gly  Thr Cys Thr Thr Thr  Thr Ala Thr Thr Gly  Ala Ala Cys 
    2765                 2770                 2775             


Ala Thr  Thr Gly Thr Cys Ala  Ala Ala Thr Thr Cys  Gly Thr Ala 
    2780                 2785                 2790             


Cys Gly  Cys Thr Thr Cys Ala  Thr Ala Gly Gly Ala  Thr Gly Gly 
    2795                 2800                 2805             


Ala Cys  Ala Thr Ala Ala Thr  Gly Thr Thr Thr Ala  Thr Ala Thr 
    2810                 2815                 2820             


Ala Ala  Thr Gly Cys Cys Cys  Thr Thr Cys Thr Thr  Ala Thr Gly 
    2825                 2830                 2835             


Thr Gly  Thr Thr Ala Cys Cys  Ala Thr Ala Gly Ala  Thr Gly Thr 
    2840                 2845                 2850             


Gly Thr  Gly Ala Ala Ala Cys  Cys Thr Thr Ala Thr  Ala Gly Cys 
    2855                 2860                 2865             


Gly Thr  Cys Cys Thr Thr Gly  Ala Ala Ala Gly Thr  Gly Thr Thr 
    2870                 2875                 2880             


Ala Ala  Ala Thr Thr Gly Ala  Gly Ala Ala Cys Thr  Cys Thr Gly 
    2885                 2890                 2895             


Thr Thr  Ala Ala Cys Ala Thr  Thr Thr Thr Ala Thr  Gly Gly Ala 
    2900                 2905                 2910             


Thr Thr  Gly Ala Cys Ala Cys  Ala Thr Thr Ala Thr  Ala Thr Thr 
    2915                 2920                 2925             


Ala Cys  Thr Gly Cys Ala Ala  Gly Thr Ala Ala Cys  Ala Thr Thr 
    2930                 2935                 2940             


Thr Gly  Ala Thr Thr Thr Thr  Cys Ala Gly Cys Ala  Cys Ala Gly 
    2945                 2950                 2955             


Thr Gly  Cys Ala Ala Ala Ala  Gly Thr Thr Cys Thr  Thr Thr Ala 
    2960                 2965                 2970             


Ala Ala  Ala Thr Gly Cys Ala  Thr Ala Thr Gly Thr  Cys Thr Thr 
    2975                 2980                 2985             


Thr Thr  Thr Thr Thr Thr Thr  Cys Thr Ala Ala Thr  Thr Cys Cys 
    2990                 2995                 3000             


Ala Thr  Thr Thr Thr Gly Thr  Thr Thr Ala Ala Ala  Gly Cys Ala 
    3005                 3010                 3015             


Cys Ala  Thr Thr Thr Thr Ala  Ala Ala Thr Gly Thr  Ala Gly Thr 
    3020                 3025                 3030             


Thr Thr  Thr Cys Thr Cys Ala  Thr Thr Thr Ala Gly  Thr Ala Ala 
    3035                 3040                 3045             


Ala Ala  Gly Thr Thr Gly Thr  Cys Thr Ala Ala Thr  Thr Gly Ala 
    3050                 3055                 3060             


Thr Ala  Cys Ala Ala Cys Gly  Thr Cys Thr Gly Ala  Gly Thr Gly 
    3065                 3070                 3075             


Ala Thr  Thr Ala Thr Thr Cys  Thr Gly Thr Gly Thr  Thr Gly Thr 
    3080                 3085                 3090             


Thr Thr  Thr Gly Thr Thr Thr  Thr Ala Cys Ala Gly  Thr Gly Ala 
    3095                 3100                 3105             


Gly Ala  Thr Ala Thr Gly Thr  Ala Ala Gly Cys Ala  Cys Ala Ala 
    3110                 3115                 3120             


Gly Thr  Thr Gly Ala Cys Ala  Thr Ala Gly Ala Cys  Thr Gly Ala 
    3125                 3130                 3135             


Ala Gly  Cys Ala Thr Ala Gly  Ala Cys Ala Gly Thr  Cys Thr Cys 
    3140                 3145                 3150             


Thr Gly  Ala Gly Cys Thr Gly  Thr Ala Gly Cys Cys  Ala Thr Gly 
    3155                 3160                 3165             


Thr Thr  Cys Thr Ala Thr Thr  Ala Gly Gly Thr Cys  Ala Cys Ala 
    3170                 3175                 3180             


Cys Ala  Thr Gly Cys Thr Thr  Thr Thr Ala Thr Thr  Thr Ala Ala 
    3185                 3190                 3195             


Thr Gly  Cys Gly Ala Thr Thr  Gly Gly Ala Thr Ala  Ala Cys Thr 
    3200                 3205                 3210             


Thr Ala  Cys Ala Thr Ala Cys  Thr Ala Gly Ala Gly  Thr Ala Ala 
    3215                 3220                 3225             


Ala Cys  Gly Ala Ala Cys Ala  Ala Thr Thr Gly Thr  Thr Thr Ala 
    3230                 3235                 3240             


Cys Thr  Cys Ala Ala Ala Cys  Ala Ala Thr Thr Gly  Cys Thr Ala 
    3245                 3250                 3255             


Ala Thr  Ala Gly Gly Ala Thr  Thr Thr Thr Ala Gly  Ala Thr Gly 
    3260                 3265                 3270             


Thr Thr  Ala Thr Cys Thr Cys  Thr Gly Ala Gly Thr  Ala Ala Thr 
    3275                 3280                 3285             


Cys Ala  Ala Thr Ala Cys Thr  Thr Ala Ala Gly Gly  Thr Ala Gly 
    3290                 3295                 3300             


Cys Thr  Cys Ala Ala Gly Ala  Ala Ala Ala Thr Ala  Ala Gly Cys 
    3305                 3310                 3315             


Cys Thr  Thr Ala Gly Thr Cys  Thr Cys Ala Ala Thr  Ala Thr Thr 
    3320                 3325                 3330             


Ala Gly  Thr Thr Ala Ala Thr  Gly Thr Ala Cys Ala  Cys Thr Ala 
    3335                 3340                 3345             


Ala Thr  Thr Thr Gly Thr Ala  Thr Cys Thr Thr Ala  Ala Ala Cys 
    3350                 3355                 3360             


Thr Gly  Thr Thr Thr Thr Gly  Thr Thr Thr Thr Thr  Thr Gly Thr 
    3365                 3370                 3375             


Ala Ala  Ala Thr Gly Thr Thr  Cys Ala Thr Thr Cys  Ala Ala Ala 
    3380                 3385                 3390             


Thr Thr  Ala Ala Ala Ala Cys  Thr Ala Gly Gly Gly  Gly Cys Gly 
    3395                 3400                 3405             


Ala Ala  Ala Ala Gly Thr Ala  Ala Gly Cys Ala Ala  Ala Thr Thr 
    3410                 3415                 3420             


Ala Gly  Thr Ala Thr Thr Gly  Gly Thr Thr Gly Thr  Thr Ala Ala 
    3425                 3430                 3435             


Ala Gly  Gly Ala Thr Ala Gly  Ala Cys Ala Thr Thr  Thr Ala Cys 
    3440                 3445                 3450             


Cys Ala  Thr Gly Thr Thr Gly  Gly Ala Ala Ala Ala  Thr Thr Ala 
    3455                 3460                 3465             


Thr Thr  Cys Ala Gly Ala Cys  Cys Thr Cys Thr Thr  Ala Ala Ala 
    3470                 3475                 3480             


Ala Cys  Thr Ala Cys Thr Thr  Thr Ala Cys Ala Gly  Cys Thr Thr 
    3485                 3490                 3495             


Cys Thr  Cys Ala Thr Ala Thr  Ala Thr Ala Ala Gly  Thr Ala Cys 
    3500                 3505                 3510             


Thr Cys  Ala Gly Thr Ala Cys  Ala Thr Cys Ala Thr  Gly Thr Gly 
    3515                 3520                 3525             


Cys Thr  Cys Cys Thr Ala Ala  Gly Ala Ala Thr Gly  Ala Thr Ala 
    3530                 3535                 3540             


Ala Cys  Ala Cys Ala Gly Ala  Thr Thr Ala Thr Thr  Ala Ala Thr 
    3545                 3550                 3555             


Thr Ala  Thr Ala Cys Thr Ala  Gly Thr Thr Thr Ala  Cys Thr Gly 
    3560                 3565                 3570             


Ala Cys  Ala Ala Ala Gly Thr  Cys Ala Cys Ala Ala  Ala Gly Ala 
    3575                 3580                 3585             


Cys Ala  Ala Ala Cys Ala Gly  Thr Ala Ala Ala Ala  Thr Ala Cys 
    3590                 3595                 3600             


Ala Gly  Gly Cys Thr Ala Cys  Cys Thr Thr Thr Ala  Ala Cys Cys 
    3605                 3610                 3615             


Cys Cys  Ala Thr Gly Ala Thr  Thr Gly Gly Thr Gly  Ala Gly Gly 
    3620                 3625                 3630             


Cys Ala  Gly Ala Cys Ala Gly  Ala Gly Ala Cys Ala  Gly Gly Thr 
    3635                 3640                 3645             


Gly Ala  Ala Thr Cys Thr Ala  Thr Gly Ala Cys Thr  Thr Gly Ala 
    3650                 3655                 3660             


Ala Gly  Cys Cys Thr Ala Gly  Ala Cys Thr Ala Cys  Ala Thr Gly 
    3665                 3670                 3675             


Thr Thr  Ala Cys Ala Gly Thr  Gly Thr Cys Thr Gly  Thr Thr Thr 
    3680                 3685                 3690             


Ala Cys  Thr Ala Gly Ala Thr  Gly Ala Ala Ala Ala  Gly Cys Thr 
    3695                 3700                 3705             


Ala Cys  Ala Ala Gly Cys Ala  Ala Thr Thr Gly Cys  Ala Gly Ala 
    3710                 3715                 3720             


Gly Ala  Ala Thr Thr Thr Gly  Gly Gly Thr Thr Cys  Ala Ala Thr 
    3725                 3730                 3735             


Thr Cys  Thr Thr Thr Thr Thr  Thr Thr Thr Thr Thr  Thr Thr Thr 
    3740                 3745                 3750             


Thr Thr  Ala Cys Ala Cys Gly  Thr Ala Thr Thr Thr  Thr Cys Cys 
    3755                 3760                 3765             


Thr Cys  Ala Ala Ala Thr Thr  Ala Cys Ala Thr Thr  Thr Cys Cys 
    3770                 3775                 3780             


Ala Ala  Thr Gly Cys Thr Ala  Thr Cys Thr Cys Ala  Ala Ala Ala 
    3785                 3790                 3795             


Gly Thr  Cys Cys Cys Cys Cys  Ala Cys Ala Cys Cys  Cys Thr Gly 
    3800                 3805                 3810             


Gly Gly  Thr Thr Cys Thr Ala  Thr Thr Cys Thr Thr  Ala Ala Cys 
    3815                 3820                 3825             


Ala Cys  Thr Cys Ala Gly Ala  Ala Gly Gly Cys Thr  Gly Thr Cys 
    3830                 3835                 3840             


Thr Gly  Thr Ala Thr Gly Gly  Cys Thr Ala Ala Gly  Cys Cys Ala 
    3845                 3850                 3855             


Ala Gly  Gly Gly Gly Ala Thr  Cys Thr Gly Cys Thr  Gly Thr Thr 
    3860                 3865                 3870             


Thr Thr  Ala Thr Gly Cys Cys  Cys Thr Cys Thr Gly  Ala Gly Gly 
    3875                 3880                 3885             


Gly Cys  Ala Cys Cys Ala Gly  Gly Cys Ala Cys Ala  Cys Ala Cys 
    3890                 3895                 3900             


Ala Thr  Gly Gly Cys Ala Cys  Ala Cys Ala Thr Gly  Gly Thr Gly 
    3905                 3910                 3915             


Gly Gly  Thr Ala Cys Ala Thr  Ala Gly Ala Cys Ala  Thr Ala Cys 
    3920                 3925                 3930             


Ala Thr  Ala Thr Ala Gly Gly  Cys Ala Ala Ala Ala  Thr Cys Cys 
    3935                 3940                 3945             


Thr Cys  Ala Thr Ala Cys Ala  Cys Ala Thr Ala Ala  Ala Ala Ala 
    3950                 3955                 3960             


Thr Ala  Ala Ala Ala Thr Gly  Thr Thr Thr Ala Ala  Ala Gly Gly 
    3965                 3970                 3975             


Ala Thr  Thr Thr Thr Thr Thr  Thr Ala Thr Thr Ala  Ala Gly Thr 
    3980                 3985                 3990             


Gly Thr  Thr Gly Ala Gly Cys  Ala Ala Ala Thr Ala  Ala Ala Ala 
    3995                 4000                 4005             


Thr Gly  Ala Gly Thr Thr Thr  Thr Thr Thr Gly Ala  Thr Thr Gly 
    4010                 4015                 4020             


Gly 
    


<210>  16
<211>  1211
<212>  DNA
<213>  Homo sapiens cyclin-dependent kinase 5 (CDK5), transcript variant 1, mRNA

<400>  16
agaaggccct gcgcgggcag acggggcggg gctggaggct caggtgccgc ctcctctgca       60

acgccggggc cagagtctta aaaccgaggg cccgcagggg tccccgcggc cgccgcgatg      120

cagaaatacg agaaactgga aaagattggg gaaggcacct acggaactgt gttcaaggcc      180

aaaaaccggg agactcatga gatcgtggct ctgaaacggg tgaggctgga tgacgatgat      240

gagggtgtgc cgagttccgc cctccgggag atctgcctac tcaaggagct gaagcacaag      300

aacatcgtca ggcttcatga cgtcctgcac agcgacaaga agctgacttt ggtttttgaa      360

ttctgtgacc aggacctgaa gaagtatttt gacagttgca atggtgacct cgatcctgag      420

attgtaaagt cattcctctt ccagctacta aaagggctgg gattctgtca tagccgcaat      480

gtgctacaca gggacctgaa gccccagaac ctgctaataa acaggaatgg ggagctgaaa      540

ttggctgatt ttggcctggc tcgagccttt gggattcccg tccgctgtta ctcagctgag      600

gtggtcacac tgtggtaccg cccaccggat gtcctctttg gggccaagct gtactccacg      660

tccatcgaca tgtggtcagc cggctgcatc tttgcagagc tggccaatgc tgggcggcct      720

ctttttcccg gcaatgatgt cgatgaccag ttgaagagga tcttccgact gctggggacg      780

cccaccgagg agcagtggcc ctctatgacc aagctgccag actataagcc ctatccgatg      840

tacccggcca caacatccct ggtgaacgtc gtgcccaaac tcaatgccac agggagggat      900

ctgctgcaga accttctgaa gtgtaaccct gtccagcgta tctcagcaga agaggccctg      960

cagcacccct acttctccga cttctgtccg ccctaggccc cgggaccccc ggcctccagg     1020

ctggggcctg gcctatttaa gccccctctt gagaggggtg agacagtggg ggtgcctggt     1080

gcgctgtgct ccagcagtgc tgggcccagc cggggtgggg tgcctgagcc cgaatttctc     1140

actccctttg tggactttat ttaatttcat aaattggctc ctttcccaca gtcaaaaaaa     1200

aaaaaaaaaa a                                                          1211


<210>  17
<211>  7095
<212>  DNA
<213>  Homo sapiens glycogen synthase kinase 3 beta (GSK3B), transcript variant 2, mRNA

<400>  17
cgggcttgtg ccgccgccgc cgccgccgcc gcccgggcca agtgacaaag gaaggaagga       60

agcgaggagg agccggcccc gcagccgctg acagggctct gggctggggc aaagcgcgga      120

cacttcctga gcgggcaccg agcagagccg aggggcggga gggcggccga gctgttgccg      180

cggacggggg agggggcccc gagggacgga agcggttgcc gggttcccat gtccccggcg      240

aatggggaac agtcgaggag ccgctgcctg gggtctgaag ggagctgcct ccgccaccgc      300

catggccgct ggatccagcc gccgcctgca gctgctcctg gcgcaatgag gagaggagcc      360

gccgccaccg ccaccgcccg cctctgactg actcgcgact ccgccgccct ctagttcgcc      420

gggcccctgc cgtcagcccg ccggatcccg cggcttgccg gagctgcagc gtttcccgtc      480

gcatctccga gccaccccct ccctccctct ccctccctcc tacccatccc cctttctctt      540

caagcgtgag actcgtgatc cttccgccgc ttcccttctt cattgactcg gaaaaaaaat      600

ccccgaggaa aatataatat tcgaagtact cattttcaat caagtatttg cccccgtttc      660

acgtgataca tattttttta ggatttgccc tctcttttct ctcctcccag gaaagggagg      720

ggaaagaatt gtattttttc ccaagtccta aatcatctat atgttaaata tccgtgccga      780

tctgtcttga aggagaaata tatcgcttgt tttgtttttt atagtataca aaaggagtga      840

aaagccaaga ggacgaagtc tttttctttt tcttctgtgg gagaacttaa tgctgcattt      900

atcgttaacc taacacccca acataaagac aaaaggaaga aaaggaggaa ggaaggaaaa      960

ggtgattcgc gaagagagtg atcatgtcag ggcggcccag aaccacctcc tttgcggaga     1020

gctgcaagcc ggtgcagcag ccttcagctt ttggcagcat gaaagttagc agagacaagg     1080

acggcagcaa ggtgacaaca gtggtggcaa ctcctgggca gggtccagac aggccacaag     1140

aagtcagcta tacagacact aaagtgattg gaaatggatc atttggtgtg gtatatcaag     1200

ccaaactttg tgattcagga gaactggtcg ccatcaagaa agtattgcag gacaagagat     1260

ttaagaatcg agagctccag atcatgagaa agctagatca ctgtaacata gtccgattgc     1320

gttatttctt ctactccagt ggtgagaaga aagatgaggt ctatcttaat ctggtgctgg     1380

actatgttcc ggaaacagta tacagagttg ccagacacta tagtcgagcc aaacagacgc     1440

tccctgtgat ttatgtcaag ttgtatatgt atcagctgtt ccgaagttta gcctatatcc     1500

attcctttgg aatctgccat cgggatatta aaccgcagaa cctcttgttg gatcctgata     1560

ctgctgtatt aaaactctgt gactttggaa gtgcaaagca gctggtccga ggagaaccca     1620

atgtttcgta tatctgttct cggtactata gggcaccaga gttgatcttt ggagccactg     1680

attatacctc tagtatagat gtatggtctg ctggctgtgt gttggctgag ctgttactag     1740

gacaaccaat atttccaggg gatagtggtg tggatcagtt ggtagaaata atcaaggtcc     1800

tgggaactcc aacaagggag caaatcagag aaatgaaccc aaactacaca gaatttaaat     1860

tccctcaaat taaggcacat ccttggacta aggtcttccg accccgaact ccaccggagg     1920

caattgcact gtgtagccgt ctgctggagt atacaccaac tgcccgacta acaccactgg     1980

aagcttgtgc acattcattt tttgatgaat tacgggaccc aaatgtcaaa ctaccaaatg     2040

ggcgagacac acctgcactc ttcaacttca ccactcaaga actgtcaagt aatccacctc     2100

tggctaccat ccttattcct cctcatgctc ggattcaagc agctgcttca acccccacaa     2160

atgccacagc agcgtcagat gctaatactg gagaccgtgg acagaccaat aatgctgctt     2220

ctgcatcagc ttccaactcc acctgaacag tcccgagcag ccagctgcac aggaaaaacc     2280

accagttact tgagtgtcac tcagcaacac tggtcacgtt tggaaagaat attaaaaaga     2340

gaaaaaaatc ctgttcattt tagtgttcaa tttttttatt attattgttg ttcttattta     2400

accttgtaaa atatctataa atacaaacca atttcattgt attctcactt tgagggagat     2460

ccagggggtg ggaggggttg tggggagggg gaaagcggag cactagaaca tacaatctct     2520

ctcccacgac aatctttttt tattaaaagt ctgctgttgt atactttaaa aacaggactc     2580

ctgcctcatg ccccttccac aaaagaagaa aacctttttc tgtgctgatg ggtttttttg     2640

aactttgttt tcttttaaag tctagtgtga gactttggta tagtgcacag cttgaaattg     2700

gttgggagct tagcaggtat aactcaacgg ggacttaaat gtcacttgta aaattaatcc     2760

atatcttcgg gtatttatag acttgccttt ggcatgttgg tggcaggtgt ggcagacaaa     2820

gaaatgtgta tcattcgtaa cccagggagg tcaataaagt ttggaactct acagggaaga     2880

ttcttagtag atttgttaag gttttgtttt gctctcagtt agtgctagtg atgtagaggc     2940

ttgtacagga ggctgccaga ggggaagcag caagcaagac tcaggcacac atgctctaca     3000

ggtggctctt tgtttgcctg accaaagttc tttgcaaatc ttagcacagt ttcaaactag     3060

tgacctggga ggagatggaa ggggtgttga gcaggctgag ctagctgctg aggtcaaagg     3120

ctgatgagcc cagaggaagg ggacaggtca gggatacatc tcaccactgt gaataagttt     3180

gtccagattt ttttctaaag ttacttccct tggaaagata cacttgagag gacattgtag     3240

ttaaataatg tgaactgtaa cagtcatcta ctggtttatt tttcatattt tttaattgaa     3300

aattgagctt gcagaaatag ccacattcta cacatagttc taattttaaa tccaaatcta     3360

gaatctgtat ttaatttgtt ttttaacctc atgcttttta catttattta ttgatgcatg     3420

tcagatggta gaaatattaa aaactacaca tcagaatgat acagtcactt atacctgctg     3480

actttatagg aaagctgatg atataaatgt gtgtatatat gttatatata catatattca     3540

atactgcctt tttttttgtc tacagtatca aaattgactg gttgaagcat gagaagaatg     3600

tttcccccac acccagttaa gagtttttgt gtctgttttc tttgtgtatc agtgaacgat     3660

gttaagaatc agtctctctt tttgaagaaa aagcaatatt ccttggaaag caaggagaat     3720

tgaaggacta tgtttgccgt gaggaaatag attttcatga ctagtttgtt ttatactttt     3780

aaggttggca tctatgtggg ccttatatac tctaaaatga actttagtca ccttggtgct     3840

tatgggccat tacttgacct atgaatcttt aaggcacaat cagttgtact ttacatttaa     3900

agatcacttg agtgatggcc gcctttccct cctacccgct ccttccccac atgccttcca     3960

aggttagctg gtaactgtag ggctgcagag ctgagcccat ggttgtgtgt aacttgccct     4020

caccctcctc attgccacct taggtcactt tatgggtctc gtcctccaga gggttcggaa     4080

gtggagtctg ttggcagccc tcctgcaggc cctagcaccc tgtcctgctc cttaactgtg     4140

tgtgtgactc tccaagagag ttgtcctgcc tgctgaagtg aaccagtacc cagaaagaca     4200

actgtgagcc atcttggttt tcactcgctg tttagctgag gtcttgggcc acaaaagggg     4260

tttcacaaac ctctggatat atcagagttt atgagaaagg aaacatgctc agtcaaacca     4320

aatcaaacaa attgaatttt atgttttata aagtgcttct gaaagctaag atttgaaaga     4380

agtctgaaat caaagtattt ggcagcataa ctccttaaag gtagtggcgt tgatagacca     4440

ttttcagaca gaatttataa agaatctgaa aaggcaggtc tgtgatagag aaatggacct     4500

gcattcagat ccaactgccc agcaagcgtt tggatgcaga cactgctctg gacgtggtat     4560

actccccaga gtccataaaa atcagtgctt attttaggaa acaggttgcc ccccacaact     4620

ggggtaaaag aagagagaaa agtcacgctt ttctctcatt tcattgtgtg tgcatgtgtg     4680

cgtgtgtgtg tgtgtgtgtg tgtgctgaga tgtgtgattt ttctttctca aggatcatgg     4740

tgggatcaca gaactctttt atacaagtga gatccaggtc tctgaatatc tttttgtata     4800

taataataat aaaaagctcc tcaccaaatt caagcttgta cattatattt tctttctgtg     4860

tttttaaatt taagttttat tgttttgtat gtaaatatgt ggacccagga actgttatta     4920

atgagcaaaa agttactgtt cagggcagtg attctgttta ataatcagac aaaatgtaga     4980

cgagcttttt aaagccatat agttttaact ctgtacagta ggtaccggcc tgtattattg     5040

taacaataac tctagcaatg tatagtgtat ctatatagtt tggagtgcct tcgcttccat     5100

gtgttttttt ttttaatttg ttctttttta aattttaatt ggtttccttt atccatgtct     5160

ccctgtccac cccctttccc tttgaaataa taactcactc ataacagtat ctttgcccct     5220

tccacagtta agtttcagtg ataccatact caggagtggg aagaggaaat catattcgta     5280

atttcatttc gttgaagccc tgcctttgtt ttggttctga atgtctttcc tcctcggtag     5340

cagtgagacc ggtttcattt catacttagt ccattcaggg acttagtgta gcaccaggga     5400

gccctagagc tggaggatat cgaatagatt aaattttgct cgtctcttcc acaagcccta     5460

accatgggtc ttaaaaacag cagattctgg gagccttcca tgctctctct ctctcctctt     5520

ttatctactt ccctcccaaa tgagagagtg acagagaatt gtttttttat aaatcgaagt     5580

ttcttaatag tatcaggttt tgatacgtca gtggtctaaa atgctatagt gcaattacta     5640

gcagttactg cacggagtgc caccgtgcca atagaggact gttgttttaa caagggaact     5700

cttagcccat ttcctccctc ccgccatctc tacccttgct caatgaaata tcattttaat     5760

ttcttttaaa aaaaatcagt ttaattctta ctgtgtgccc aacacgaagg ccttttttga     5820

aagaaaaata gaatgttttg cctcaaagta gtccatataa aatgtcttga atagaagaaa     5880

aaactaccaa accaaaggtt actatttttg aaacatcgtg tgttcattcc agcaaggcag     5940

aagactgcac cttctttcca gtgacatgct gtgtcatttt ttttaagtcc tcttaatttt     6000

tagacacatt tttggtttat gttttaacaa tgtatgccta accagtcatc ttgtctgcac     6060

caatgcaaag gtttctgaga ggagtattct ctatccctgt ggatatgaag acactggcat     6120

ttcatctatt tttccctttc ctttttaaag gatttaactt tggaatcttc caaaggaagt     6180

ttggccaatg ccagatcccc aggaatttgg ggggttttct ttcttttcaa ctgaaattgt     6240

atctgattcc tactgttcat gttagtgatc atctaatcac agagccaaac acttttctcc     6300

cctgtgtgga aaagtaggta tgctttacaa taaaatctgt cttttctggt agaaacctga     6360

gccactgaaa ataaaagaga caactagaag cacagtagag tcccagactg agatctacct     6420

ttgagaggct ttgaaagtaa tccctggggt ttggattatt ttcacaaggg ttatgccgtt     6480

ttattcaagt ttgttgctcc gttttgcacc tctgcaataa aagcaaaatg acaaccagta     6540

cataaggggt tagcttgaca aagtagactt ccttgtgtta atttttaagt ttttttttcc     6600

ttaactatat ctgtctacag gcagatacag atagttgtat gaaaatctgc ttgcctgtaa     6660

aatttgcatt tataaatgtg ttgccgatgg atcacttggg cctgtacaca taccaattag     6720

cgtgaccact tccatcttaa aaacaaacct aaaaaacaaa atttattata tatatatata     6780

tatatatata aaggactgtg ggttgtatac aaactattgc aaacacttgt gcaaatctgt     6840

cttgatataa aggaaaagca aaatctgtat aacattatta ctacttgaat gcctctgtga     6900

ctgatttttt tttcatttta aatataaact tttttgtgaa aagtatgctc aatgtttttt     6960

ttccctttcc ccattccctt gtaaatacat tttgttctat gtgacttggt ttggaaatag     7020

ttaactggta ctgtaatttg cattaaataa aaagtaggtt agcctggaaa tgaaattaaa     7080

aaaaaaaaaa aaaaa                                                      7095


<210>  18
<211>  8787
<212>  DNA
<213>  Homo Sapiens PKC

<400>  18
ggccgcagct ccccggcgga ggcaagaggt ggttgggggg gaccatggct gacgttttcc       60

cgggcaacga ctccacggcg tctcaggacg tggccaaccg cttcgcccgc aaaggggcgc      120

tgaggcagaa gaacgtgcac gaggtgaagg accacaaatt catcgcgcgc ttcttcaagc      180

agcccacctt ctgcagccac tgcaccgact tcatctgggg gtttgggaaa caaggcttcc      240

agtgccaagt ttgctgtttt gtggtccaca agaggtgcca tgaatttgtt actttttctt      300

gtccgggtgc ggataaggga cccgacactg atgaccccag gagcaagcac aagttcaaaa      360

tccacactta cggaagcccc accttctgcg atcactgtgg gtcactgctc tatggactta      420

tccatcaagg gatgaaatgt gacacctgcg atatgaacgt tcacaagcaa tgcgtcatca      480

atgtccccag cctctgcgga atggatcaca ctgagaagag ggggcggatt tacctaaagg      540

ctgaggttgc tgatgaaaag ctccatgtca cagtacgaga tgcaaaaaat ctaatcccta      600

tggatccaaa cgggctttca gatccttatg tgaagctgaa acttattcct gatcccaaga      660

atgaaagcaa gcaaaaaacc aaaaccatcc gctccacact aaatccgcag tggaatgagt      720

cctttacatt caaattgaaa ccttcagaca aagaccgacg actgtctgta gaaatctggg      780

actgggatcg aacaacaagg aatgacttca tgggatccct ttcctttgga gtttcggagc      840

tgatgaagat gccggccagt ggatggtaca agttgcttaa ccaagaagaa ggtgagtact      900

acaacgtacc cattccggaa ggggacgagg aaggaaacat ggaactcagg cagaaattcg      960

agaaagccaa acttggccct gctggcaaca aagtcatcag tccctctgaa gacaggaaac     1020

aaccttccaa caaccttgac cgagtgaaac tcacggactt caatttcctc atggtgttgg     1080

gaaaggggag ttttggaaag gtgatgcttg ccgacaggaa gggcacagaa gaactgtatg     1140

caatcaaaat cctgaagaag gatgtggtga ttcaggatga tgacgtggag tgcaccatgg     1200

tagaaaagcg agtcttggcc ctgcttgaca aacccccgtt cttgacgcag ctgcactcct     1260

gcttccagac agtggatcgg ctgtacttcg tcatggaata tgtcaacggt ggggacctca     1320

tgtaccacat tcagcaagta ggaaaattta aggaaccaca agcagtattc tatgcggcag     1380

agatttccat cggattgttc tttcttcata aaagaggaat catttatagg gatctgaagt     1440

tagataacgt catgttggat tcagaaggac atatcaaaat tgctgacttt gggatgtgca     1500

aggaacacat gatggatgga gtcacgacca ggaccttctg tgggactcca gattatatcg     1560

ccccagagat aatcgcttat cagccgtatg gaaaatctgt ggactggtgg gcctatggcg     1620

tcctgttgta tgaaatgctt gccgggcagc ctccatttga tggtgaagat gaagacgagc     1680

tatttcagtc tatcatggag cacaacgttt cctatccaaa atccttgtcc aaggaggctg     1740

tttctatctg caaaggactg atgaccaaac acccagccaa gcggctgggc tgtgggcctg     1800

agggggagag ggacgtgaga gagcatgcct tcttccggag gatcgactgg gaaaaactgg     1860

agaacaggga gatccagcca ccattcaagc ccaaagtgtg tggcaaagga gcagagaact     1920

ttgacaagtt cttcacacga ggacagcccg tcttaacacc acctgatcag ctggttattg     1980

ctaacataga ccagtctgat tttgaagggt tctcgtatgt caacccccag tttgtgcacc     2040

ccatcttaca gagtgcagta tgaaactcac cagcgagaac aaacacctcc ccagccccca     2100

gccctccccg cagtgggaag tgaatcctta accctaaaat tttaaggcca cggccttgtg     2160

tctgattcca tatggaggcc tgaaaattgt agggttatta gtccaaatgt gatcaactgt     2220

tcagggtctc tctcttacaa ccaagaacat tatcttagtg gaagatggta cgtcatgctc     2280

agtgtccagt ttaattctgt agaagttacg tctggctcta ggttaaccct tcctagaaag     2340

caagcagact gttgccccat tttgggtaca atttgatata ctttccatac cctccatctg     2400

tggatttttc agcattggaa tcccccaacc agagatgtta aagtgagcct gtcccaggaa     2460

acatctccac ccaagacgtc tttggaatcc aagaacagga agccaagaga gtgagcaggg     2520

agggattggg ggtgggggag gcctcaaaat accgactgcg tccattctct gcctccatgg     2580

aaacagcccc tagaatctga aaggccggga taaacctaat cactgttccc aaacattgac     2640

aaatcctaac ccaaccatgg tccagcagtt accagtttaa acaaaaaaac ctcagatgag     2700

tgttgggtga atctgtcatc tggtaccctc cttggttgat aactgtcttg atacttttca     2760

ttctttgtaa gaggccaaat cgtctaagga cgttgctgaa caagcgtgtg aaatcatttc     2820

agatcaagga taagccagtg tgtacatatg ttcattttaa tctctgggag attatttttc     2880

catccagggt gccatcagta atcatgccac tactcaccag tgttgttcgc caacacccac     2940

ccccacacac accaacattt tgctgcctac cttgttatcc ttctcaagaa gctgaagtgt     3000

acgccctctc cccttttgtg cttatttatt taataggctg cagtgtcgct tatgaaagta     3060

cgatgtacag taacttaatg gaagtgctga ctctagcatc agcctctacc gattgatttt     3120

cctcccttct ctagccctgg atgtccactt agggataaaa agaatatggt tttggttccc     3180

atttctagtt cacgttgaat gacaggcctg gagctgtaga atcaggaaac ccggatgcct     3240

aacagctcaa agatgttttg ttaatagaag gattttaata cgttttgcaa atgcatcatg     3300

caatgaattt tgcatgttta taataaacct taataacaag tgaatctata ttattgatat     3360

aatcgtatca agtataaaga gagtattata ataattttat aagacacaat tgtgctctat     3420

ttgtgcaggt tcttgtttct aatcctcttt tctaattaag ttttagctga atcccttgct     3480

tctgtgcttt ccctccctgc acatgggcac tgtatcagat agattacttt ttaaatgtag     3540

ataaaatttc aaaaatgaat ggctagttta cgtgatagat taggctctta ctacatatgt     3600

gtgtgtatat atatgtattt gattctacct gcaaacaaat ttttattggt gaggactatt     3660

tttgagctga cactccctct tagtttcttc atgtcacctt tcgtcctggt tcctccgcca     3720

ctcttcctct tggggacaac aggaagtgtc tgattccagt ctgcctagta cgttggtaca     3780

cacgtggcat tgccgcagca cctgggctga cctttgtgtg tgcgtgtgtg tgtgtttcct     3840

tcttcccttc agcctgtgac tgttgctgac tccaggggtg ggagggatgg ggagactccc     3900

ctcttgctgt gtgtactgga cacgcaggaa gcatgctgtc ttgctgcctc tgcaacgacc     3960

tgtcgtttgc tccagcatgc acaaacttcg tgagaccaac acagccgtgc cctgcaggca     4020

ccagcacgtg cttttcagag gctgcggact ttcttccagc cattgtggca ttggcctttc     4080

cagtcttggg aggagcgcgc tgctttggtg agacaccccc atgcaaggtc ctcagagtag     4140

ccgggttcta ccacaaacag aaacagaatg aaagtagctg tcagtccttg tagagagccg     4200

ctctgtttcc tcccagaagc atctcccagc taagctcgca ttatttttct cctctggctg     4260

tttgcctgaa gttcacagaa cacacaacca tgaaaggctt tttgaggtga gaggcccagg     4320

tggtcctggc aaccctgagt agaaggagag acggggtagg gaacgggccc ggccagaaaa     4380

gaaccatttc ttctgccatc ttttatgcac catagacatc gagactccag ggggtcctgg     4440

ctcccctgtc cctgcagccc tgcaggtcag tgcatgatct gggttcgtgt cctgaccagg     4500

tgctcctcct ttgatccgag gggaaaggga ctggtttata gaaagagcct aggagacaaa     4560

agggccagtc cccctgccca gaatggagca gcagcaggac agacccccac gaggcccccc     4620

agagaggagg aagatcccac ggaggaacac atgaggttag ggacccttgt tcagcacccc     4680

aaacagcctg cctgtttaaa gcaggcagca ggcttaggcc ttccctgcaa ccccaacacc     4740

cacaagtttg tttctctagg aaacacattc actgtctcag ctggctgtta ctctctcaga     4800

ccatatggca aagttttcca agaaaatgcc ccgacagggg tgcccagcac actgcctgag     4860

ggacaacaga catcagaaca aacccccaga gagaaacagt caaaatcagg gcccggtgca     4920

gtgttgtcat gtggaacctg ctttatccat tgctgagtgt tgaatgtggg taatggttag     4980

ggctttccag atctcagcag ccaaagacag ttattgttgg aagactgtca tgtagataac     5040

catgagcaat ggctcgcctc agaatcagtt cataaaattc tatggtactg gccccttcgt     5100

gggtattgtg tgaaatgaga tggtggcgag gggtgcgctg tggaactgcc gcagccacgc     5160

aggaggtccc tgggggatgc tttgggaagt ccttgcccct gagcactgcc tgattgccag     5220

ggcctgtgga ggtctaggcc gcctggcaga atctagcacc gtccgaatcc ccgcaggacc     5280

catggagcta tgaccacacc aggccattca aatggctctg cattatcttc ccttggaagg     5340

tggccactcc tcggtggcag ggcctttccc tgaggctgca ggccgtgggc tggcagcccg     5400

tctcttggca tttcaattga aggtcaccag gtgctgggtt tgaaaggaag tcactggagt     5460

gctgccaggg gccgccctcc aaggttaatg agaggcccac atccaggcaa gaactaattc     5520

aaaaggcaga tcagaaacca caggagtcaa aattattgct ccggcagtgc ttcccttcct     5580

ttcatccact ggcctcgtgt ggtccatgca gggccactgt ctgccctttc tgatgccacg     5640

tattaggctt tcttactcag aattttgata gaaaaccatg gggccaagag ctctggaagc     5700

ctggccggaa agaccaaggt tcatgcagcc caacaaatga ttgttgagca cctctcggag     5760

ccaaagtcct taggcgagtg tggtgacttc ctggaaggag gatgcagact tccagagagc     5820

ccccccaacg gacgtgctga gaagggagag ggaggcgggg gctgtagtca ggaaggagcc     5880

agagaagaac agggtttggg tgcatccaga aatatgcctg cagtaggagg gagaggaagg     5940

ggtgccaccg tcaacggctt cccatcggag gtggttggtg cagatggaag tttctgtctg     6000

ctggccctca agagagtgtt ttgccaggga cacagtctgt tcctcctcag aaaacacccc     6060

ccaaatgcta acaacatccc caccagctgc tagaagcccc tttcccctcc ccaccttgaa     6120

gtagctcata gttctctggg cagagccaga ccatccagtg taccccagag gccagtaggt     6180

tcctgcccat tttcctctct ggcttcctgc caagaattat ggcagctgag gatgaatgga     6240

gaagtaaaaa caactaacac cgcacaacta acaactaaca ccgcagttcc cacctgggtt     6300

ccacttagca ggagacattt cggagggttt tttttgtttt tgttcctgtt tttttttttt     6360

ttgctggaat ttgttttctc agtactgaaa agagaaaaag tgacaatctt gtatttttaa     6420

aagcctcgga aaggtgatac catctgacag tcattttctc acgttggtct tctaaagtca     6480

cctatttctt gtgtgtgcac atcacaccat ttcctgtttc tttataaccc gacaagggta     6540

ggagtgcctg tttcccctgc tgggcacacc agacaatcgt aatcacaaaa cagacactga     6600

gccaggggcc caaagggtgt gatcatgaga gttaccggga cagcagtagg catgacagtc     6660

accaggaagg acaagggtgc tctgttgtta gtggccacac accaatttga caaggagtgt     6720

tgcgaaattt ttatttattt atttatttat tttgagatgg agtttcactc ttgttgccca     6780

ggctggagtg cggtggtaca atctcggctc actgcaacct ccacctccca ggttcaagcg     6840

attctcctgc ctcagcctcc caagtacctg ggactacagg tgcgtgccac cacacccagc     6900

taaattttgt gtttttagta gagatggggt ttcaccatgt tggccaggat ggtcttgaac     6960

ccctgacctc atgatctgcc tgcctcggcc tcccaaagtg ctgggattac aggcatgagc     7020

caccacgccc agccaaaata tttttttaaa gtcattttcc ttaagctgct tgggctacat     7080

gtgaaataca ctggacggtc aacattcctg tctcctccca tttgggctga tgcagcagat     7140

ccagggaatg ttacctgttt ctgctgctag aagatccagg aaattgggaa ggttacctga     7200

cgcacacatg gatgaaggcc atcatctaga aatggggtca accacaattg tgttaattcc     7260

gtagtgtcag ggattcttcg ggaaggtcaa cagtatgaag gattctgacc cctgtgcctc     7320

ccatttatgt gatcaggtga cagttaataa ccgtggaggt cacactcagc catccaacag     7380

ccttacagtg accctacaca aaagccccca aattccaaag actttttctt aacctaaagg     7440

aagaaattat ttgttaattc cagtagagca actgaatata ctgggctatt tgtacttttt     7500

tatagagaac tttaataata attctttaaa aatgagtttt tagaacaaag caactgacga     7560

tttcctaaga ttccaatgcc ctggagcttg taggaggact tagcctgggt cagctggagc     7620

acccccgacc tgatctccca ctgccagatt ttcccatgct cctagggtat ggagtccacg     7680

tgggaatgac tgcaagttca ggtggaactt ggccgactga tgctctgcga gtttttaata     7740

gacactgggg acaactgctt aaggtttaga aacttccaaa ccacaggaaa gacattttta     7800

gtgtccccca tccagaggca gccctggaat aggattccca ggggtttctg ggaccccttt     7860

ccttgctccg tgaggctctg tggccatctt ttggcaggag gaggatgctt ccttggctct     7920

gtgcccagac ccgcctggtc cccaggtctc tcaccttggg tgaagattca gagatgccct     7980

gtaaggattt tgcccactgg gcaactcaga aatacttcga tctcccaaga tataagaggc     8040

agcagcaaac gtgcctattg acgtctgttt catagttacc acttacgcga gtagacagaa     8100

ctcggctttt cagaaaatag gtgtcaagtc cactttataa gaaccttttt ttctaaaata     8160

agataaaagg tggctttgca ttttctgatt aaacgactgt gtctttgtca cctctgctta     8220

actttaggag tatccattcc tgtgattgta gacttttgtt gatattcttc ctggaagaat     8280

atcattcttt tcttgaaggg ttggtttact agaatattca aaatcaatca tgaaggcagt     8340

tactattttg agtctaaagg ttttctaaaa attaacctca catcccttct gttagggtct     8400

ttcagaatat cttttataaa cagaagcatt tgaagtcatt gcttttgcta catgatttgt     8460

gtgtgtgaag gacataccac gtttaaatca ttaattgaaa aacatcatat aagccccaac     8520

tttgtttgga ggaagagacg gaggttgagg tttttccttc tgtataagca cctactgaca     8580

aaatgtagag gccattcaac cgtcaaacac catttggtta tatcgcagag gagacggatg     8640

tgtaaattac tgcattgctt tttttttcag tttgtataac ctctaatctc cgtttgcatg     8700

atacgctttg ttagaaacat taattgtagt ttggaagcaa gtgtgtatga ataaagataa     8760

tgatcattcc aaaaaaaaaa aaaaaaa                                         8787


<210>  19
<211>  1961
<212>  DNA
<213>  Homo sapiens NCK adaptor protein 1 (NCK1), transcript variant 1, mRNA

<400>  19
accgcgcgtg ccccgcctct ctcccaagag ctacgcggcg gcggcggagc gcaggcctcg       60

tgccgttacg gccatcacgg cggccgcagt ggcgtcctgg agccctcctc agtgctgaag      120

ctgctgaaag atggcagaag aagtggtggt agtagccaaa tttgattatg tggcccaaca      180

agaacaagag ttggacatca agaagaatga gagattatgg cttctggatg attctaagtc      240

ctggtggcga gttcgaaatt ccatgaataa aacaggtttt gtgccttcta actatgtgga      300

aaggaaaaac agtgctcgga aagcatctat tgtgaaaaac ctaaaggata ccttaggcat      360

tggaaaagtg aaaagaaaac ctagtgtgcc agattctgca tctcctgctg atgatagttt      420

tgttgaccca ggggaacgtc tctatgacct caacatgccc gcttatgtga aatttaacta      480

catggctgag agagaggatg aattatcatt gataaagggg acaaaggtga tcgtcatgga      540

gaaatgcagt gatgggtggt ggcgtggtag ctacaatgga caagttggat ggttcccttc      600

aaactatgta actgaagaag gtgacagtcc tttgggtgac catgtgggtt ctctgtcaga      660

gaaattagca gcagtcgtca ataacctaaa tactgggcaa gtgttgcatg tggtacaggc      720

tctttaccca ttcagctcat ctaatgatga agaacttaat ttcgagaaag gagatgtaat      780

ggatgttatt gaaaaacctg aaaatgaccc agagtggtgg aaatgcagga agatcaatgg      840

tatggttggt ctagtaccaa aaaactatgt taccgttatg cagaataatc cattaacttc      900

aggtttggaa ccatcacctc cacagtgtga ttacattagg ccttcactca ctggaaagtt      960

tgctggcaat ccttggtatt atggcaaagt caccaggcat caagcagaaa tggcattaaa     1020

tgaaagagga catgaagggg atttcctcat tcgtgatagt gaatcttcgc caaatgattt     1080

ctcagtatca ctaaaagcac aagggaaaaa caagcatttt aaagtccaac taaaagagac     1140

tgtctactgc attgggcagc gtaaattcag caccatggaa gaacttgtag aacattacaa     1200

aaaggcacca atttttacaa gtgaacaagg agaaaaatta tatcttgtca agcatttatc     1260

atgatactgc tgaccagaag tgactgctgt gtagctgtaa tttgtcatgt aattgaagac     1320

tgagaaaatg ttgggtccag tcgtgcttga ttggaaattg ttgtttctaa atctatatga     1380

gaattgacaa taagtatttt tattataact cagcccatac atatatacta tgtatgcagt     1440

gcatctgcat agaacagttc cttatccttg gccttctgtt ttattgtttt tttctttgct     1500

gttttccctt tgcttctaat attacagttt tgtattttgt aaacaaaaat caaataatgc     1560

atatcagaat ctttatatgg aagaaatcct ttattgcctt tcctttgttt ccttgtaaag     1620

gcaccctgtt ctgttatggt ttttcattat ataaaattat tatatctata tatgacatat     1680

gctaaaattt cttggagagt gttaatcttt tctgtgacta aatagcaata ataagtggaa     1740

aattagaaat tatttccagg tattatattt gtcacaggcc attgtaaata ccaagtatat     1800

tgtgtctgcc ataattttta aaaatacatt cattgtcttc agtcatacag caagacacat     1860

gagacataga ttagaaaaca tgttgtacaa ttttaattta caactgttgg aaataaaaat     1920

cacttaattt ttttccaaaa aaaaaaaaaa aaaaaaaaaa a                         1961


<210>  20
<211>  286
<212>  PRT
<213>  Homo sapiens protein phosphatase 1, catalytic subunit, alpha isozyme (PPP1CA), transcript variant 2, mRNA

<400>  20

Met Ser Asp Ser Glu Lys Leu Asn Leu Asp Ser Ile Ile Gly Arg Leu 
1               5                   10                  15      


Leu Glu Gly Asp Ile His Gly Gln Tyr Tyr Asp Leu Leu Arg Leu Phe 
            20                  25                  30          


Glu Tyr Gly Gly Phe Pro Pro Glu Ser Asn Tyr Leu Phe Leu Gly Asp 
        35                  40                  45              


Tyr Val Asp Arg Gly Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu 
    50                  55                  60                  


Ala Tyr Lys Ile Lys Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn 
65                  70                  75                  80  


His Glu Cys Ala Ser Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys 
                85                  90                  95      


Lys Arg Arg Tyr Asn Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe 
            100                 105                 110         


Asn Cys Leu Pro Ile Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys 
        115                 120                 125             


His Gly Gly Leu Ser Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg 
    130                 135                 140                 


Ile Met Arg Pro Thr Asp Val Pro Asp Gln Gly Leu Leu Cys Asp Leu 
145                 150                 155                 160 


Leu Trp Ser Asp Pro Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp 
                165                 170                 175     


Arg Gly Val Ser Phe Thr Phe Gly Ala Glu Val Val Ala Lys Phe Leu 
            180                 185                 190         


His Lys His Asp Leu Asp Leu Ile Cys Arg Ala His Gln Val Val Glu 
        195                 200                 205             


Asp Gly Tyr Glu Phe Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser 
    210                 215                 220                 


Ala Pro Asn Tyr Cys Gly Glu Phe Asp Asn Ala Gly Ala Met Met Ser 
225                 230                 235                 240 


Val Asp Glu Thr Leu Met Cys Ser Phe Gln Ile Leu Lys Pro Ala Asp 
                245                 250                 255     


Lys Asn Lys Gly Lys Tyr Gly Gln Phe Ser Gly Leu Asn Pro Gly Gly 
            260                 265                 270         


Arg Pro Ile Thr Pro Pro Arg Asn Ser Ala Lys Ala Lys Lys 
        275                 280                 285     


<210>  21
<211>  330
<212>  PRT
<213>  Mus musculus protein phosphatase 1, catalytic subunit, alpha isoform (Ppp1ca)

<400>  21

Met Ser Asp Ser Glu Lys Leu Asn Leu Asp Ser Ile Ile Gly Arg Leu 
1               5                   10                  15      


Leu Glu Val Gln Gly Ser Arg Pro Gly Lys Asn Val Gln Leu Thr Glu 
            20                  25                  30          


Asn Glu Ile Arg Gly Leu Cys Leu Lys Ser Arg Glu Ile Phe Leu Ser 
        35                  40                  45              


Gln Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp 
    50                  55                  60                  


Ile His Gly Gln Tyr Tyr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly 
65                  70                  75                  80  


Phe Pro Pro Glu Ser Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg 
                85                  90                  95      


Gly Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile 
            100                 105                 110         


Arg Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala 
        115                 120                 125             


Ser Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Tyr 
    130                 135                 140                 


Asn Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro 
145                 150                 155                 160 


Ile Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu 
                165                 170                 175     


Ser Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro 
            180                 185                 190         


Thr Asp Val Pro Asp Gln Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp 
        195                 200                 205             


Pro Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser 
    210                 215                 220                 


Phe Thr Phe Gly Ala Glu Val Val Ala Lys Phe Leu His Lys His Asp 
225                 230                 235                 240 


Leu Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu 
                245                 250                 255     


Phe Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr 
            260                 265                 270         


Cys Gly Glu Phe Asp Asn Ala Gly Ala Met Met Ser Val Asp Glu Thr 
        275                 280                 285             


Leu Met Cys Ser Phe Gln Ile Leu Lys Pro Ala Asp Lys Asn Lys Gly 
    290                 295                 300                 


Lys Tyr Gly Gln Phe Ser Gly Leu Asn Pro Gly Gly Arg Pro Ile Thr 
305                 310                 315                 320 


Pro Pro Arg Asn Ser Ala Lys Ala Lys Lys 
                325                 330 


<210>  22
<211>  327
<212>  PRT
<213>  Homo sapiens protein phosphatase 1, catalytic subunit, beta isozyme (PPP1CB), transcript variant 1, mRNA

<400>  22

Met Ala Asp Gly Glu Leu Asn Val Asp Ser Leu Ile Thr Arg Leu Leu 
1               5                   10                  15      


Glu Val Arg Gly Cys Arg Pro Gly Lys Ile Val Gln Met Thr Glu Ala 
            20                  25                  30          


Glu Val Arg Gly Leu Cys Ile Lys Ser Arg Glu Ile Phe Leu Ser Gln 
        35                  40                  45              


Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp Ile 
    50                  55                  60                  


His Gly Gln Tyr Thr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly Phe 
65                  70                  75                  80  


Pro Pro Glu Ala Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly 
                85                  90                  95      


Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile Lys 
            100                 105                 110         


Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala Ser 
        115                 120                 125             


Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Phe Asn 
    130                 135                 140                 


Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro Ile 
145                 150                 155                 160 


Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu Ser 
                165                 170                 175     


Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro Thr 
            180                 185                 190         


Asp Val Pro Asp Thr Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp Pro 
        195                 200                 205             


Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser Phe 
    210                 215                 220                 


Thr Phe Gly Ala Asp Val Val Ser Lys Phe Leu Asn Arg His Asp Leu 
225                 230                 235                 240 


Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu Phe 
                245                 250                 255     


Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr Cys 
            260                 265                 270         


Gly Glu Phe Asp Asn Ala Gly Gly Met Met Ser Val Asp Glu Thr Leu 
        275                 280                 285             


Met Cys Ser Phe Gln Ile Leu Lys Pro Ser Glu Lys Lys Ala Lys Tyr 
    290                 295                 300                 


Gln Tyr Gly Gly Leu Asn Ser Gly Arg Pro Val Thr Pro Pro Arg Thr 
305                 310                 315                 320 


Ala Asn Pro Pro Lys Lys Arg 
                325         


<210>  23
<211>  327
<212>  PRT
<213>  Mus musculus protein phosphatase 1, catalytic subunit, beta isoform (Ppp1cb)

<400>  23

Met Ala Asp Gly Glu Leu Asn Val Asp Ser Leu Ile Thr Arg Leu Leu 
1               5                   10                  15      


Glu Val Arg Gly Cys Arg Pro Gly Lys Ile Val Gln Met Thr Glu Ala 
            20                  25                  30          


Glu Val Arg Gly Leu Cys Ile Lys Ser Arg Glu Ile Phe Leu Ser Gln 
        35                  40                  45              


Pro Ile Leu Leu Glu Leu Glu Ala Pro Leu Lys Ile Cys Gly Asp Ile 
    50                  55                  60                  


His Gly Gln Tyr Thr Asp Leu Leu Arg Leu Phe Glu Tyr Gly Gly Phe 
65                  70                  75                  80  


Pro Pro Glu Ala Asn Tyr Leu Phe Leu Gly Asp Tyr Val Asp Arg Gly 
                85                  90                  95      


Lys Gln Ser Leu Glu Thr Ile Cys Leu Leu Leu Ala Tyr Lys Ile Lys 
            100                 105                 110         


Tyr Pro Glu Asn Phe Phe Leu Leu Arg Gly Asn His Glu Cys Ala Ser 
        115                 120                 125             


Ile Asn Arg Ile Tyr Gly Phe Tyr Asp Glu Cys Lys Arg Arg Phe Asn 
    130                 135                 140                 


Ile Lys Leu Trp Lys Thr Phe Thr Asp Cys Phe Asn Cys Leu Pro Ile 
145                 150                 155                 160 


Ala Ala Ile Val Asp Glu Lys Ile Phe Cys Cys His Gly Gly Leu Ser 
                165                 170                 175     


Pro Asp Leu Gln Ser Met Glu Gln Ile Arg Arg Ile Met Arg Pro Thr 
            180                 185                 190         


Asp Val Pro Asp Thr Gly Leu Leu Cys Asp Leu Leu Trp Ser Asp Pro 
        195                 200                 205             


Asp Lys Asp Val Gln Gly Trp Gly Glu Asn Asp Arg Gly Val Ser Phe 
    210                 215                 220                 


Thr Phe Gly Ala Asp Val Val Ser Lys Phe Leu Asn Arg His Asp Leu 
225                 230                 235                 240 


Asp Leu Ile Cys Arg Ala His Gln Val Val Glu Asp Gly Tyr Glu Phe 
                245                 250                 255     


Phe Ala Lys Arg Gln Leu Val Thr Leu Phe Ser Ala Pro Asn Tyr Cys 
            260                 265                 270         


Gly Glu Phe Asp Asn Ala Gly Gly Met Met Ser Val Asp Glu Thr Leu 
        275                 280                 285             


Met Cys Ser Phe Gln Ile Leu Lys Pro Ser Glu Lys Lys Ala Lys Tyr 
    290                 295                 300                 


Gln Tyr Gly Gly Leu Asn Ser Gly Arg Pro Val Thr Pro Pro Arg Thr 
305                 310                 315                 320 


Ala Asn Pro Pro Lys Lys Arg 
                325         


<210>  24
<211>  292
<212>  PRT
<213>  Homo sapiens cyclin-dependent kinase 5 (CDK5)

<400>  24

Met Gln Lys Tyr Glu Lys Leu Glu Lys Ile Gly Glu Gly Thr Tyr Gly 
1               5                   10                  15      


Thr Val Phe Lys Ala Lys Asn Arg Glu Thr His Glu Ile Val Ala Leu 
            20                  25                  30          


Lys Arg Val Arg Leu Asp Asp Asp Asp Glu Gly Val Pro Ser Ser Ala 
        35                  40                  45              


Leu Arg Glu Ile Cys Leu Leu Lys Glu Leu Lys His Lys Asn Ile Val 
    50                  55                  60                  


Arg Leu His Asp Val Leu His Ser Asp Lys Lys Leu Thr Leu Val Phe 
65                  70                  75                  80  


Glu Phe Cys Asp Gln Asp Leu Lys Lys Tyr Phe Asp Ser Cys Asn Gly 
                85                  90                  95      


Asp Leu Asp Pro Glu Ile Val Lys Ser Phe Leu Phe Gln Leu Leu Lys 
            100                 105                 110         


Gly Leu Gly Phe Cys His Ser Arg Asn Val Leu His Arg Asp Leu Lys 
        115                 120                 125             


Pro Gln Asn Leu Leu Ile Asn Arg Asn Gly Glu Leu Lys Leu Ala Asp 
    130                 135                 140                 


Phe Gly Leu Ala Arg Ala Phe Gly Ile Pro Val Arg Cys Tyr Ser Ala 
145                 150                 155                 160 


Glu Val Val Thr Leu Trp Tyr Arg Pro Pro Asp Val Leu Phe Gly Ala 
                165                 170                 175     


Lys Leu Tyr Ser Thr Ser Ile Asp Met Trp Ser Ala Gly Cys Ile Phe 
            180                 185                 190         


Ala Glu Leu Ala Asn Ala Gly Arg Pro Leu Phe Pro Gly Asn Asp Val 
        195                 200                 205             


Asp Asp Gln Leu Lys Arg Ile Phe Arg Leu Leu Gly Thr Pro Thr Glu 
    210                 215                 220                 


Glu Gln Trp Pro Ser Met Thr Lys Leu Pro Asp Tyr Lys Pro Tyr Pro 
225                 230                 235                 240 


Met Tyr Pro Ala Thr Thr Ser Leu Val Asn Val Val Pro Lys Leu Asn 
                245                 250                 255     


Ala Thr Gly Arg Asp Leu Leu Gln Asn Leu Leu Lys Cys Asn Pro Val 
            260                 265                 270         


Gln Arg Ile Ser Ala Glu Glu Ala Leu Gln His Pro Tyr Phe Ser Asp 
        275                 280                 285             


Phe Cys Pro Pro 
    290         


<210>  25
<211>  420
<212>  PRT
<213>  Homo sapiens glycogen synthase kinase 3 beta (GSK3B), transcript variant 2, mRNA

<400>  25

Met Ser Gly Arg Pro Arg Thr Thr Ser Phe Ala Glu Ser Cys Lys Pro 
1               5                   10                  15      


Val Gln Gln Pro Ser Ala Phe Gly Ser Met Lys Val Ser Arg Asp Lys 
            20                  25                  30          


Asp Gly Ser Lys Val Thr Thr Val Val Ala Thr Pro Gly Gln Gly Pro 
        35                  40                  45              


Asp Arg Pro Gln Glu Val Ser Tyr Thr Asp Thr Lys Val Ile Gly Asn 
    50                  55                  60                  


Gly Ser Phe Gly Val Val Tyr Gln Ala Lys Leu Cys Asp Ser Gly Glu 
65                  70                  75                  80  


Leu Val Ala Ile Lys Lys Val Leu Gln Asp Lys Arg Phe Lys Asn Arg 
                85                  90                  95      


Glu Leu Gln Ile Met Arg Lys Leu Asp His Cys Asn Ile Val Arg Leu 
            100                 105                 110         


Arg Tyr Phe Phe Tyr Ser Ser Gly Glu Lys Lys Asp Glu Val Tyr Leu 
        115                 120                 125             


Asn Leu Val Leu Asp Tyr Val Pro Glu Thr Val Tyr Arg Val Ala Arg 
    130                 135                 140                 


His Tyr Ser Arg Ala Lys Gln Thr Leu Pro Val Ile Tyr Val Lys Leu 
145                 150                 155                 160 


Tyr Met Tyr Gln Leu Phe Arg Ser Leu Ala Tyr Ile His Ser Phe Gly 
                165                 170                 175     


Ile Cys His Arg Asp Ile Lys Pro Gln Asn Leu Leu Leu Asp Pro Asp 
            180                 185                 190         


Thr Ala Val Leu Lys Leu Cys Asp Phe Gly Ser Ala Lys Gln Leu Val 
        195                 200                 205             


Arg Gly Glu Pro Asn Val Ser Tyr Ile Cys Ser Arg Tyr Tyr Arg Ala 
    210                 215                 220                 


Pro Glu Leu Ile Phe Gly Ala Thr Asp Tyr Thr Ser Ser Ile Asp Val 
225                 230                 235                 240 


Trp Ser Ala Gly Cys Val Leu Ala Glu Leu Leu Leu Gly Gln Pro Ile 
                245                 250                 255     


Phe Pro Gly Asp Ser Gly Val Asp Gln Leu Val Glu Ile Ile Lys Val 
            260                 265                 270         


Leu Gly Thr Pro Thr Arg Glu Gln Ile Arg Glu Met Asn Pro Asn Tyr 
        275                 280                 285             


Thr Glu Phe Lys Phe Pro Gln Ile Lys Ala His Pro Trp Thr Lys Val 
    290                 295                 300                 


Phe Arg Pro Arg Thr Pro Pro Glu Ala Ile Ala Leu Cys Ser Arg Leu 
305                 310                 315                 320 


Leu Glu Tyr Thr Pro Thr Ala Arg Leu Thr Pro Leu Glu Ala Cys Ala 
                325                 330                 335     


His Ser Phe Phe Asp Glu Leu Arg Asp Pro Asn Val Lys Leu Pro Asn 
            340                 345                 350         


Gly Arg Asp Thr Pro Ala Leu Phe Asn Phe Thr Thr Gln Glu Leu Ser 
        355                 360                 365             


Ser Asn Pro Pro Leu Ala Thr Ile Leu Ile Pro Pro His Ala Arg Ile 
    370                 375                 380                 


Gln Ala Ala Ala Ser Thr Pro Thr Asn Ala Thr Ala Ala Ser Asp Ala 
385                 390                 395                 400 


Asn Thr Gly Asp Arg Gly Gln Thr Asn Asn Ala Ala Ser Ala Ser Ala 
                405                 410                 415     


Ser Asn Ser Thr 
            420 


<210>  26
<211>  672
<212>  PRT
<213>  Homo Sapiens PKC

<400>  26

Met Ala Asp Val Phe Pro Gly Asn Asp Ser Thr Ala Ser Gln Asp Val 
1               5                   10                  15      


Ala Asn Arg Phe Ala Arg Lys Gly Ala Leu Arg Gln Lys Asn Val His 
            20                  25                  30          


Glu Val Lys Asp His Lys Phe Ile Ala Arg Phe Phe Lys Gln Pro Thr 
        35                  40                  45              


Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly 
    50                  55                  60                  


Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu 
65                  70                  75                  80  


Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Asp Thr Asp 
                85                  90                  95      


Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Gly Ser Pro 
            100                 105                 110         


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln 
        115                 120                 125             


Gly Met Lys Cys Asp Thr Cys Asp Met Asn Val His Lys Gln Cys Val 
    130                 135                 140                 


Ile Asn Val Pro Ser Leu Cys Gly Met Asp His Thr Glu Lys Arg Gly 
145                 150                 155                 160 


Arg Ile Tyr Leu Lys Ala Glu Val Ala Asp Glu Lys Leu His Val Thr 
                165                 170                 175     


Val Arg Asp Ala Lys Asn Leu Ile Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Asn Glu Ser 
        195                 200                 205             


Lys Gln Lys Thr Lys Thr Ile Arg Ser Thr Leu Asn Pro Gln Trp Asn 
    210                 215                 220                 


Glu Ser Phe Thr Phe Lys Leu Lys Pro Ser Asp Lys Asp Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Ile Trp Asp Trp Asp Arg Thr Thr Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ser Leu Ser Phe Gly Val Ser Glu Leu Met Lys Met Pro Ala Ser 
            260                 265                 270         


Gly Trp Tyr Lys Leu Leu Asn Gln Glu Glu Gly Glu Tyr Tyr Asn Val 
        275                 280                 285             


Pro Ile Pro Glu Gly Asp Glu Glu Gly Asn Met Glu Leu Arg Gln Lys 
    290                 295                 300                 


Phe Glu Lys Ala Lys Leu Gly Pro Ala Gly Asn Lys Val Ile Ser Pro 
305                 310                 315                 320 


Ser Glu Asp Arg Lys Gln Pro Ser Asn Asn Leu Asp Arg Val Lys Leu 
                325                 330                 335     


Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser Phe Gly Lys 
            340                 345                 350         


Val Met Leu Ala Asp Arg Lys Gly Thr Glu Glu Leu Tyr Ala Ile Lys 
        355                 360                 365             


Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val Glu Cys Thr 
    370                 375                 380                 


Met Val Glu Lys Arg Val Leu Ala Leu Leu Asp Lys Pro Pro Phe Leu 
385                 390                 395                 400 


Thr Gln Leu His Ser Cys Phe Gln Thr Val Asp Arg Leu Tyr Phe Val 
                405                 410                 415     


Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile Gln Gln Val 
            420                 425                 430         


Gly Lys Phe Lys Glu Pro Gln Ala Val Phe Tyr Ala Ala Glu Ile Ser 
        435                 440                 445             


Ile Gly Leu Phe Phe Leu His Lys Arg Gly Ile Ile Tyr Arg Asp Leu 
    450                 455                 460                 


Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile Lys Ile Ala 
465                 470                 475                 480 


Asp Phe Gly Met Cys Lys Glu His Met Met Asp Gly Val Thr Thr Arg 
                485                 490                 495     


Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile Ile Ala Tyr 
            500                 505                 510         


Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Tyr Gly Val Leu Leu 
        515                 520                 525             


Tyr Glu Met Leu Ala Gly Gln Pro Pro Phe Asp Gly Glu Asp Glu Asp 
    530                 535                 540                 


Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ser Tyr Pro Lys Ser 
545                 550                 555                 560 


Leu Ser Lys Glu Ala Val Ser Ile Cys Lys Gly Leu Met Thr Lys His 
                565                 570                 575     


Pro Ala Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg Asp Val Arg 
            580                 585                 590         


Glu His Ala Phe Phe Arg Arg Ile Asp Trp Glu Lys Leu Glu Asn Arg 
        595                 600                 605             


Glu Ile Gln Pro Pro Phe Lys Pro Lys Val Cys Gly Lys Gly Ala Glu 
    610                 615                 620                 


Asn Phe Asp Lys Phe Phe Thr Arg Gly Gln Pro Val Leu Thr Pro Pro 
625                 630                 635                 640 


Asp Gln Leu Val Ile Ala Asn Ile Asp Gln Ser Asp Phe Glu Gly Phe 
                645                 650                 655     


Ser Tyr Val Asn Pro Gln Phe Val His Pro Ile Leu Gln Ser Ala Val 
            660                 665                 670         


<210>  27
<211>  377
<212>  PRT
<213>  Homo sapiens NCK adaptor protein 1 (NCK1), transcript variant 1, mRNA

<400>  27

Met Ala Glu Glu Val Val Val Val Ala Lys Phe Asp Tyr Val Ala Gln 
1               5                   10                  15      


Gln Glu Gln Glu Leu Asp Ile Lys Lys Asn Glu Arg Leu Trp Leu Leu 
            20                  25                  30          


Asp Asp Ser Lys Ser Trp Trp Arg Val Arg Asn Ser Met Asn Lys Thr 
        35                  40                  45              


Gly Phe Val Pro Ser Asn Tyr Val Glu Arg Lys Asn Ser Ala Arg Lys 
    50                  55                  60                  


Ala Ser Ile Val Lys Asn Leu Lys Asp Thr Leu Gly Ile Gly Lys Val 
65                  70                  75                  80  


Lys Arg Lys Pro Ser Val Pro Asp Ser Ala Ser Pro Ala Asp Asp Ser 
                85                  90                  95      


Phe Val Asp Pro Gly Glu Arg Leu Tyr Asp Leu Asn Met Pro Ala Tyr 
            100                 105                 110         


Val Lys Phe Asn Tyr Met Ala Glu Arg Glu Asp Glu Leu Ser Leu Ile 
        115                 120                 125             


Lys Gly Thr Lys Val Ile Val Met Glu Lys Cys Ser Asp Gly Trp Trp 
    130                 135                 140                 


Arg Gly Ser Tyr Asn Gly Gln Val Gly Trp Phe Pro Ser Asn Tyr Val 
145                 150                 155                 160 


Thr Glu Glu Gly Asp Ser Pro Leu Gly Asp His Val Gly Ser Leu Ser 
                165                 170                 175     


Glu Lys Leu Ala Ala Val Val Asn Asn Leu Asn Thr Gly Gln Val Leu 
            180                 185                 190         


His Val Val Gln Ala Leu Tyr Pro Phe Ser Ser Ser Asn Asp Glu Glu 
        195                 200                 205             


Leu Asn Phe Glu Lys Gly Asp Val Met Asp Val Ile Glu Lys Pro Glu 
    210                 215                 220                 


Asn Asp Pro Glu Trp Trp Lys Cys Arg Lys Ile Asn Gly Met Val Gly 
225                 230                 235                 240 


Leu Val Pro Lys Asn Tyr Val Thr Val Met Gln Asn Asn Pro Leu Thr 
                245                 250                 255     


Ser Gly Leu Glu Pro Ser Pro Pro Gln Cys Asp Tyr Ile Arg Pro Ser 
            260                 265                 270         


Leu Thr Gly Lys Phe Ala Gly Asn Pro Trp Tyr Tyr Gly Lys Val Thr 
        275                 280                 285             


Arg His Gln Ala Glu Met Ala Leu Asn Glu Arg Gly His Glu Gly Asp 
    290                 295                 300                 


Phe Leu Ile Arg Asp Ser Glu Ser Ser Pro Asn Asp Phe Ser Val Ser 
305                 310                 315                 320 


Leu Lys Ala Gln Gly Lys Asn Lys His Phe Lys Val Gln Leu Lys Glu 
                325                 330                 335     


Thr Val Tyr Cys Ile Gly Gln Arg Lys Phe Ser Thr Met Glu Glu Leu 
            340                 345                 350         


Val Glu His Tyr Lys Lys Ala Pro Ile Phe Thr Ser Glu Gln Gly Glu 
        355                 360                 365             


Lys Leu Tyr Leu Val Lys His Leu Ser 
    370                 375         


<210>  28
<211>  21
<212>  DNA
<213>  Human PP1

<400>  28
gagacgcuac aacaucaaat t                                                 21


<210>  29
<211>  21
<212>  DNA
<213>  Human PP1

<400>  29
uuugauguug uagcgucuct t                                                 21


<210>  30
<211>  21
<212>  RNA
<213>  Human PP1

<400>  30
gugcucuuac gguuuauugu u                                                 21


<210>  31
<211>  21
<212>  DNA
<213>  Human PP1

<400>  31
guauacaccu agaguuuuat t                                                 21


<210>  32
<211>  21
<212>  DNA
<213>  Human PP1

<400>  32
uaaaacucua gguguauact t                                                 21


<210>  33
<211>  21
<212>  RNA
<213>  Human PP1

<400>  33
gcuuucuaug gacuaauaaa u                                                 21


<210>  34
<211>  5916
<212>  DNA
<213>  Homo sapiens P38

<400>  34
gcccctccct ccgcccgccc gccggcccgc ccgtcagtct ggcaggcagg caggcaatcg       60

gtccgagtgg ctgtcggctc ttcagctctc ccgctcggcg tcttccttcc tcctcccggt      120

cagcgtcggc ggctgcaccg gcggcggcgc agtccctgcg ggaggggcga caagagctga      180

gcggcggccg ccgagcgtcg agctcagcgc ggcggaggcg gcggcggccc ggcagccaac      240

atggcggcgg cggcggcggc gggcgcgggc ccggagatgg tccgcgggca ggtgttcgac      300

gtggggccgc gctacaccaa cctctcgtac atcggcgagg gcgcctacgg catggtgtgc      360

tctgcttatg ataatgtcaa caaagttcga gtagctatca agaaaatcag cccctttgag      420

caccagacct actgccagag aaccctgagg gagataaaaa tcttactgcg cttcagacat      480

gagaacatca ttggaatcaa tgacattatt cgagcaccaa ccatcgagca aatgaaagat      540

gtatatatag tacaggacct catggaaaca gatctttaca agctcttgaa gacacaacac      600

ctcagcaatg accatatctg ctattttctc taccagatcc tcagagggtt aaaatatatc      660

cattcagcta acgttctgca ccgtgacctc aagccttcca acctgctgct caacaccacc      720

tgtgatctca agatctgtga ctttggcctg gcccgtgttg cagatccaga ccatgatcac      780

acagggttcc tgacagaata tgtggccaca cgttggtaca gggctccaga aattatgttg      840

aattccaagg gctacaccaa gtccattgat atttggtctg taggctgcat tctggcagaa      900

atgctttcta acaggcccat ctttccaggg aagcattatc ttgaccagct gaaccacatt      960

ttgggtattc ttggatcccc atcacaagaa gacctgaatt gtataataaa tttaaaagct     1020

aggaactatt tgctttctct tccacacaaa aataaggtgc catggaacag gctgttccca     1080

aatgctgact ccaaagctct ggacttattg gacaaaatgt tgacattcaa cccacacaag     1140

aggattgaag tagaacaggc tctggcccac ccatatctgg agcagtatta cgacccgagt     1200

gacgagccca tcgccgaagc accattcaag ttcgacatgg aattggatga cttgcctaag     1260

gaaaagctca aagaactaat ttttgaagag actgctagat tccagccagg atacagatct     1320

taaatttgtc aggacaaggg ctcagaggac tggacgtgct cagacatcgg tgttcttctt     1380

cccagttctt gacccctggt cctgtctcca gcccgtcttg gcttatccac tttgactcct     1440

ttgagccgtt tggaggggcg gtttctggta gttgtggctt ttatgctttc aaagaatttc     1500

ttcagtccag agaattcctc ctggcagccc tgtgtgtgtc acccattggt gacctgcggc     1560

agtatgtact tcagtgcacc tactgcttac tgttgcttta gtcactaatt gctttctggt     1620

ttgaaagatg cagtggttcc tccctctcct gaatcctttt ctacatgatg ccctgctgac     1680

catgcagccg caccagagag agattcttcc ccaattggct ctagtcactg gcatctcact     1740

ttatgatagg gaaggctact acctagggca ctttaagtca gtgacagccc cttatttgca     1800

cttcaccttt tgaccataac tgtttcccca gagcaggagc ttgtggaaat accttggctg     1860

atgttgcagc ctgcagcaag tgcttccgtc tccggaatcc ttggggagca cttgtccacg     1920

tcttttctca tatcatggta gtcactaaca tatataaggt atgtgctatt ggcccagctt     1980

ttagaaaatg cagtcatttt tctaaataaa aaggaagtac tgcacccagc agtgtcactc     2040

tgtagttact gtggtcactt gtaccatata gaggtgtaac acttgtcaag aagcgttatg     2100

tgcagtactt aatgtttgta agacttacaa aaaaagattt aaagtggcag cttcactcga     2160

catttggtga gagaagtaca aaggttgcag tgctgagctg tgggcggttt ctggggatgt     2220

cccagggtgg aactccacat gctggtgcat atacgccctt gagctacttc aaatgtgggt     2280

gtttcagtaa ccacgttcca tgcctgagga tttagcagag aggaacactg cgtctttaaa     2340

tgagaaagta tacaattctt tttccttcta cagcatgtca gcatctcaag ttcatttttc     2400

aacctacagt ataacaattt gtaataaagc ctccaggagc tcatgacgtg aagcactgtt     2460

ctgtcctcaa gtactcaaat atttctgata ctgctgagtc agactgtcag aaaaagctag     2520

cactaactcg tgtttggagc tctatccata ttttactgat ctctttaagt atttgttcct     2580

gccactgtgt actgtggagt tgactcggtg ttctgtccca gtgcggtgcc tcctcttgac     2640

ttccccactg ctctctgtgg tgagaaattt gccttgttca ataattactg taccctcgca     2700

tgactgttac agctttctgt gcagagatga ctgtccaagt gccacatgcc tacgattgaa     2760

atgaaaactc tattgttacc tctgagttgt gttccacgga aaatgctatc cagcagatca     2820

tttaggaaaa ataattctat ttttagcttt tcatttctca gctgtccttt tttcttgttt     2880

gatttttgac agcaatggag aatgggttat ataaagactg cctgctaata tgaacagaaa     2940

tgcatttgta attcatgaaa ataaatgtac atcttctatc ttcacattca tgttaagatt     3000

cagtgttgct ttcctctgga tcagcgtgtc tgaatggaca gtcaggttca ggttgtgctg     3060

aacacagaaa tgctcacagg cctcactttg ccgcccaggc actggcccag cacttggatt     3120

tacataagat gagttagaaa ggtacttctg tagggtcctt tttacctctg ctcggcagag     3180

aatcgatgct gtcatgttcc tttattcaca atcttaggtc tcaaatattc tgtcaaaccc     3240

taacaaagaa gccccgacat ctcaggttgg attccctggt tctctctaaa gagggcctgc     3300

ccttgtgccc cagaggtgct gctgggcaca gccaagagtt gggaagggcc gccccacagt     3360

acgcagtcct caccacccag cccagggtgc tcacgctcac cactcctgtg gctgaggaag     3420

gatagctggc tcatcctcgg aaaacagacc cacatctcta ttcttgccct gaaatacgcg     3480

cttttcactt gcgtgctcag agctgccgtc tgaaggtcca cacagcattg acgggacaca     3540

gaaatgtgac tgttaccgga taacactgat tagtcagttt tcatttataa aaaagcattg     3600

acagttttat tactcttgtt tctttttaaa tggaaagtta ctattataag gttaatttgg     3660

agtcctcttc taaatagaaa accatatcct tggctactaa catctggaga ctgtgagctc     3720

cttcccattc cccttcctgg tactgtggag tcagattggc atgaaaccac taacttcatt     3780

ctagaatcat tgtagccata agttgtgtgc tttttattaa tcatgccaaa cataatgtaa     3840

ctgggcagag aatggtccta accaaggtac ctatgaaaag cgctagctat catgtgtagt     3900

agatgcatca ttttggctct tcttacattt gtaaaaatgt acagattagg tcatcttaat     3960

tcatattagt gacacggaac agcacctcca ctatttgtat gttcaaataa gctttcagac     4020

taatagcttt tttggtgtct aaaatgtaag caaaaaattc ctgctgaaac attccagtcc     4080

tttcatttag tataaaagaa atactgaaca agccagtggg atggaattga aagaactaat     4140

catgaggact ctgtcctgac acaggtcctc aaagctagca gagatacgca gacattgtgg     4200

catctgggta gaagaatact gtattgtgtg tgcagtgcac agtgtgtggt gtgtgcacac     4260

tcattccttc tgctcttggg cacaggcagt gggtgtagag gtaaccagta gctttgagaa     4320

gctacatgta gctcaccagt ggttttctct aaggaatcac aaaagtaaac tacccaacca     4380

catgccacgt aatatttcag ccattcagag gaaactgttt tctctttatt tgcttatatg     4440

ttaatatggt ttttaaattg gtaactttta tatagtatgg taacagtatg ttaatacaca     4500

catacatacg cacacatgct ttgggtcctt ccataatact tttatatttg taaatcaatg     4560

ttttggagca atcccaagtt taagggaaat atttttgtaa atgtaatggt tttgaaaatc     4620

tgagcaatcc ttttgcttat acatttttaa agcatttgtg ctttaaaatt gttatgctgg     4680

tgtttgaaac atgatactcc tgtggtgcag atgagaagct ataacagtga atatgtggtt     4740

tctcttacgt catccacctt gacatgatgg gtcagaaaca aatggaaatc cagagcaagt     4800

cctccagggt tgcaccaggt ttacctaaag cttgttgcct tttcttgtgc tgtttatgcg     4860

tgtagagcac tcaagaaagt tctgaaactg ctttgtatct gctttgtact gttggtgcct     4920

tcttggtatt gtaccccaaa attctgcata gattatttag tataatggta agttaaaaaa     4980

tgttaaagga agattttatt aagaatctga atgtttattc attatattgt tacaatttaa     5040

cattaacatt tatttgtggt atttgtgatt tggttaatct gtataaaaat tgtaagtaga     5100

aaggtttata tttcatctta attcttttga tgttgtaaac gtacttttta aaagatggat     5160

tatttgaatg tttatggcac ctgacttgta aaaaaaaaaa actacaaaaa aatccttaga     5220

atcattaaat tgtgtccctg tattaccaaa ataacacagc accgtgcatg tatagtttaa     5280

ttgcagtttc atctgtgaaa acgtgaaatt gtctagtcct tcgttatgtt ccccagatgt     5340

cttccagatt tgctctgcat gtggtaactt gtgttagggc tgtgagctgt tcctcgagtt     5400

gaatggggat gtcagtgctc ctagggttct ccaggtggtt cttcagacct tcacctgtgg     5460

gggggggggt aggcggtgcc cacgcccatc tcctcatcct cctgaacttc tgcaacccca     5520

ctgctgggca gacatcctgg gcaacccctt ttttcagagc aagaagtcat aaagatagga     5580

tttcttggac atttggttct tatcaatatt gggcattatg taatgactta tttacaaaac     5640

aaagatactg gaaaatgttt tggatgtggt gttatggaaa gagcacaggc cttggaccca     5700

tccagctggg ttcagaacta ccccctgctt ataactgcgg ctggctgtgg gccagtcatt     5760

ctgcgtctct gctttcttcc tctgcttcag actgtcagct gtaaagtgga agcaatatta     5820

cttgccttgt atatggtaaa gattataaaa atacatttca actgttcagc atagtacttc     5880

aaagcaagta ctcagtaaat agcaagtctt tttaaa                               5916


<210>  35
<211>  1417
<212>  DNA
<213>  Homo sapiens jnk

<400>  35
attaattgct tgccatcatg agcagaagca agcgtgacaa caatttttat agtgtagaga       60

ttggagattc tacattcaca gtcctgaaac gatatcagaa tttaaaacct ataggctcag      120

gagctcaagg aatagtatgc gcagcttatg atgccattct tgaaagaaat gttgcaatca      180

agaagctaag ccgaccattt cagaatcaga ctcatgccaa gcgggcctac agagagctag      240

ttcttatgaa atgtgttaat cacaaaaata taattggcct tttgaatgtt ttcacaccac      300

agaaatccct agaagaattt caagatgttt acatagtcat ggagctcatg gatgcaaatc      360

tttgccaagt gattcagatg gagctagatc atgaaagaat gtcctacctt ctctatcaga      420

tgctgtgtgg aatcaagcac cttcattctg ctggaattat tcatcgggac ttaaagccca      480

gtaatatagt agtaaaatct gattgcactt tgaagattct tgacttcggt ctggccagga      540

ctgcaggaac gagttttatg atgacgcctt atgtagtgac tcgctactac agagcacccg      600

aggtcatcct tggcatgggc tacaaggaaa acgtggattt atggtctgtg gggtgcatta      660

tgggagaaat ggtttgccac aaaatcctct ttccaggaag ggactatatt gatcagtgga      720

ataaagttat tgaacagctt ggaacaccat gtcctgaatt catgaagaaa ctgcaaccaa      780

cagtaaggac ttacgttgaa aacagaccta aatatgctgg atatagcttt gagaaactct      840

tccctgatgt ccttttccca gctgactcag aacacaacaa acttaaagcc agtcaggcaa      900

gggatttgtt atccaaaatg ctggtaatag atgcatctaa aaggatctct gtagatgaag      960

ctctccaaca cccgtacatc aatgtctggt atgatccttc tgaagcagaa gctccaccac     1020

caaagatccc tgacaagcag ttagatgaaa gggaacacac aatagaagag tggaaagaat     1080

tgatatataa ggaagttatg gacttggagg agagaaccaa gaatggagtt atacgggggc     1140

agccctctcc tttagcacag gtgcagcagt gatcaatggc tctcagcatc catcatcatc     1200

gtcgtctgtc aatgatgtgt cttcaatgtc aacagatccg actttggcct ctgatacaga     1260

cagcagtcta gaagcagcag ctgggcctct gggctgctgt agatgactac ttgggccatc     1320

ggggggtggg agggatgggg agtcggttag tcattgatag aactactttg aaaacaattc     1380

agtggtctta tttttgggtg atttttcaaa aaatgta                              1417


<210>  36
<211>  4145
<212>  DNA
<213>  Homo sapiens src

<400>  36
caaacaagtg cggccatttc accagcccag gctggcttct gctgttgact ggctgtggca       60

cctcaagcag cccctttccc ctctagcctc agtttatcac cgcaagagct accattcatc      120

tagcacaacc tgaccatcct cacactggtc agttccaacc ttcccaggaa tcttctgtgg      180

ccatgttcac tccggtttta cagaacagag aacagaagct cagagaagtg aagcaacttg      240

cccagctatg agagacagag ccaggatttg aaaccagatg aggacgctga ggcccagaga      300

gggaaagcca cttgcctagg gacacacagc ggggagaggt ggagcagggc ctctatttcg      360

agacccctga ctccacacct ggtgtttgtg ccaagacccc aggctgcctc ccaggtcctc      420

tgggacagcc cctgccttct accaggacca tgggtagcaa caagagcaag cccaaggatg      480

ccagccagcg gcgccgcagc ctggagcccg ccgagaacgt gcacggcgct ggcgggggcg      540

ctttccccgc ctcgcagacc cccagcaagc cagcctcggc cgacggccac cgcggcccca      600

gcgcggcctt cgcccccgcg gccgccgagc ccaagctgtt cggaggcttc aactcctcgg      660

acaccgtcac ctccccgcag agggcgggcc cgctggccgg tggagtgacc acctttgtgg      720

ccctctatga ctatgagtct aggacggaga cagacctgtc cttcaagaaa ggcgagcggc      780

tccagattgt caacaacaca gagggagact ggtggctggc ccactcgctc agcacaggac      840

agacaggcta catccccagc aactacgtgg cgccctccga ctccatccag gctgaggagt      900

ggtattttgg caagatcacc agacgggagt cagagcggtt actgctcaat gcagagaacc      960

cgagagggac cttcctcgtg cgagaaagtg agaccacgaa aggtgcctac tgcctctcag     1020

tgtctgactt cgacaacgcc aagggcctca acgtgaagca ctacaagatc cgcaagctgg     1080

acagcggcgg cttctacatc acctcccgca cccagttcaa cagcctgcag cagctggtgg     1140

cctactactc caaacacgcc gatggcctgt gccaccgcct caccaccgtg tgccccacgt     1200

ccaagccgca gactcagggc ctggccaagg atgcctggga gatccctcgg gagtcgctgc     1260

ggctggaggt caagctgggc cagggctgct ttggcgaggt gtggatgggg acctggaacg     1320

gtaccaccag ggtggccatc aaaaccctga agcctggcac gatgtctcca gaggccttcc     1380

tgcaggaggc ccaggtcatg aagaagctga ggcatgagaa gctggtgcag ttgtatgctg     1440

tggtttcaga ggagcccatt tacatcgtca cggagtacat gagcaagggg agtttgctgg     1500

actttctcaa gggggagaca ggcaagtacc tgcggctgcc tcagctggtg gacatggctg     1560

ctcagatcgc ctcaggcatg gcgtacgtgg agcggatgaa ctacgtccac cgggaccttc     1620

gtgcagccaa catcctggtg ggagagaacc tggtgtgcaa agtggccgac tttgggctgg     1680

ctcggctcat tgaagacaat gagtacacgg cgcggcaagg tgccaaattc cccatcaagt     1740

ggacggctcc agaagctgcc ctctatggcc gcttcaccat caagtcggac gtgtggtcct     1800

tcgggatcct gctgactgag ctcaccacaa agggacgggt gccctaccct gggatggtga     1860

accgcgaggt gctggaccag gtggagcggg gctaccggat gccctgcccg ccggagtgtc     1920

ccgagtccct gcacgacctc atgtgccagt gctggcggaa ggagcctgag gagcggccca     1980

ccttcgagta cctgcaggcc ttcctggagg actacttcac gtccaccgag ccccagtacc     2040

agcccgggga gaacctctag gcacaggcgg gcccagaccg gcttctcggc ttggatcctg     2100

ggctgggtgg cccctgtctc ggggcttgcc ccactctgcc tgcctgctgt tggtcctctc     2160

tctgtggggc tgaattgcca ggggcgaggc ccttcctctt tggtggcatg gaaggggctt     2220

ctggacctag ggtggcctga gagggcggtg ggtatgcgag accagcacgg tgactctgtc     2280

cagctcccgc tgtggccgca cgcctctccc tgcactccct cctggagctc tgtgggtctc     2340

tggaagagga accaggagaa gggctggggc cggggctgag ggtgcccttt tccagcctca     2400

gcctactccg ctcactgaac tccttcccca cttctgtgcc acccccggtc tatgtcgaga     2460

gctggccaaa gagcctttcc aaagaggagc gatgggcccc tggccccgcc tgcctgccac     2520

cctgcccctt gccatccatt ctggaaacac ctgtaggcag aggctgccga gacagaccct     2580

ctgccgctgc ttccaggctg ggcagcacaa ggccttgcct ggcctgatga tggtgggtgg     2640

gtgggatgag taccccctca aaccctgccc tccttagacc tgagggaccc ttcgagatca     2700

tcacttcctt gcccccattt cacccatggg gagacagttg agagcgggga tgtgacatgc     2760

ccaaggccac ggagcagttc agagtggagg cgggcttgga acccggtgct ccctctgtca     2820

tcctcaggaa ccaacaattc gtcggaggca tcatggaaag actgggacag cccaggaaac     2880

aaggggtctg aggatgcatt cgagatggca gattcccact gccgctgccc gctcagccca     2940

gctgttggga acagcatgga ggcagatgtg gggctgagct ggggaatcag ggtaaaaggt     3000

gcaggtgtgg agagagaggc ttcaatcggc ttgtgggtga tgtttgacct tcagagccag     3060

ccggctatga aagggagcga gcccctcggc tctggaggca atcaagcaga catagaagag     3120

ccaagagtcc aggaggccct ggtcctggcc tccttccccg tactttgtcc cgtggcattt     3180

caattcctgg ccctgttctc ctccccaagt cggcaccctt taactcatga ggagggaaaa     3240

gagtgcctaa gcgggggtga aagaggacgt gttacccact gccatgcacc aggactggct     3300

gtgtaacctt gggtggcccc tgctgtctct ctgggctgca gagtctgccc cacatgtggc     3360

catggcctct gcaactgctc agctctggtc caggccctgt ggcaggacac acatggtgag     3420

cctagccctg ggacatcagg agactgggct ctggctctgt tcggcctttg ggtgtgtggt     3480

ggattctccc tgggcctcag tgtgcccatc tgtaaagggg cagctgacag tttgtggcat     3540

cttgccaagg gtccctgtgt gtgtgtatgt gtgtgcatgt gtgcgtgtct ccatgtgcgt     3600

ccatatttaa catgtaaaaa tgtccccccc gctccgtccc ccaaacatgt tgtacatttc     3660

accatggccc cctcatcata gcaataacat tcccactgcc aggggttctt gagccagcca     3720

ggccctgcca gtggggaagg aggccaagca gtgcctgcct atgaaatttc aacttttcct     3780

ttcatacgtc tttattaccc aagtcttctc ccgtccattc cagtcaaatc tgggctcact     3840

caccccagcg agctctcaaa tccctctcca actgcctaag gccctttgtg taaggtgtct     3900

taatactgtc cttttttttt ttttaacagt gttttgtaga tttcagatga ctatgcagag     3960

gcctggggga cccctggctc tgggccgggc ctggggctcc gaaattccaa ggcccagact     4020

tgcggggggt gggggggtat ccagaattgg ttgtaaatac tttgcatatt gtctgattaa     4080

acacaaacag acctcagaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa     4140

aaaaa                                                                 4145


<210>  37
<211>  2689
<212>  DNA
<213>  Homo sapiens caspase 3

<400>  37
acatctcccg gcggcgggcc gcggaagcag tgcagacgcg gctcctagcg gatgggtgct       60

attgtgaggc ggttgtagaa gagtttcgtg agtgctcgca gctcatacct gtggctgtgt      120

atccgtggcc acagctggtt ggcgtcgcct tgaaatccca ggccgtgagg agttagcgag      180

ccctgctcac actcggcgct ctggttttcg gtgggtgtgc cctgcacctg cctcttcccc      240

cattctcatt aataaaggta tccatggaga acactgaaaa ctcagtggat tcaaaatcca      300

ttaaaaattt ggaaccaaag atcatacatg gaagcgaatc aatggactct ggaatatccc      360

tggacaacag ttataaaatg gattatcctg agatgggttt atgtataata attaataata      420

agaattttca taaaagcact ggaatgacat ctcggtctgg tacagatgtc gatgcagcaa      480

acctcaggga aacattcaga aacttgaaat atgaagtcag gaataaaaat gatcttacac      540

gtgaagaaat tgtggaattg atgcgtgatg tttctaaaga agatcacagc aaaaggagca      600

gttttgtttg tgtgcttctg agccatggtg aagaaggaat aatttttgga acaaatggac      660

ctgttgacct gaaaaaaata acaaactttt tcagagggga tcgttgtaga agtctaactg      720

gaaaacccaa acttttcatt attcaggcct gccgtggtac agaactggac tgtggcattg      780

agacagacag tggtgttgat gatgacatgg cgtgtcataa aataccagtg gaggccgact      840

tcttgtatgc atactccaca gcacctggtt attattcttg gcgaaattca aaggatggct      900

cctggttcat ccagtcgctt tgtgccatgc tgaaacagta tgccgacaag cttgaattta      960

tgcacattct tacccgggtt aaccgaaagg tggcaacaga atttgagtcc ttttcctttg     1020

acgctacttt tcatgcaaag aaacagattc catgtattgt ttccatgctc acaaaagaac     1080

tctattttta tcactaaaga aatggttggt tggtggtttt ttttagtttg tatgccaagt     1140

gagaagatgg tatatttggt actgtatttc cctctcattt tgacctactc tcatgctgca     1200

gagggtactt taagacatac tccttccatc aaatagaacc actatgaagc tacctcaaac     1260

ttccagtcag gtagttgcaa ttgaattaaa ttaggaataa ataaaaatgg atactggtgc     1320

agtcattatg agaggcaatg attgttaatt tacagctttc atgattagca agttacagtg     1380

atgctgtgct atgaattttc aagtaattgt gaaaaagtta aacattgaag taatgaattt     1440

ttatgatatt ccccccactt aagactgtgt attctagttt tgtcaaactg tagaaatgat     1500

gatgtggaag aacttaggca tctgtgggca tggtcaaagg ctcaaacctt tattttagaa     1560

ttgatataca cggatgactt aactgcattt ttagaccatt tatctgggat tatggttttg     1620

tgatgtttgt cctgaacact tttgttgtaa aaaaataata ataatgttta atattgagaa     1680

agaaactaat attttatgtg agagaaagtg tgagcaaact aacttgactt ttaaggctaa     1740

aacttaacat tcatagaggg gtggagtttt aactgtaagg tgctacaatg cccctggatc     1800

taccagcata aatatcttct gatttgtccc tatgcatatc agttgagctt catataccag     1860

caatatatct gaagagctat tatataaaaa ccccaaactg ttgattatta gccaggtaat     1920

gtgaataaat tctataggaa catatgaaaa tacaacttaa ataataaaca gtggaatata     1980

aggaaagcaa taaatgaatg ggctgagctg cctgtaactt gagagtagat ggtttgagcc     2040

tgagcagaga catgactcag cctgttccat gaaggcagag ccatggacca cgcaggaagg     2100

gcctacagcc catttctcca tacgcactgg tatgtgtgga tgatgctgcc agggcgccat     2160

cgccaagtaa gaaagtgaag caaatcagaa acttgtgaag tggaaatgtt ctaaaggtgg     2220

tgaggcaata aaaatcatag tactctttgt agcaaaattc ttaagtatgt tattttctgt     2280

tgaagtttac aatcaaagga aaatagtaat gttttatact gtttactgaa agaaaaagac     2340

ctatgagcac ataggactct agacggcatc cagccggagg ccagagctga gccctcagcc     2400

cgggaggcag gctccaggcc tcagcaggtg cggagccgtc actgcaccaa gtctcactgg     2460

ctgtcagtat gacatttcac gggagatttc ttgttgctca aaaaatgagc tcgcatttgt     2520

caatgacagt ttcttttttc ttactagacc tgtaactttt gtaaatacac atagcatgta     2580

atggtatctt aaagtgtgtt tctatgtgac aattttgtac aaatttgtta ttttccattt     2640

ttatttcaaa atatacattc aaacttaaaa ttaaaaaaaa aaaaaaaaa                 2689


<210>  38
<211>  3007
<212>  DNA
<213>  Homo sapiens calpain 1, large subunit

<400>  38
aaggagagag ggagggcgga gggcggaggg gcggcgggag gagggcgggg aggagcgctc       60

ttcctggttg ggccctgccc tgagctgcca ccgggaagcc agcctcaggg actgcagcga      120

cccccaaaca cccctccccc aggatgtcgg aggagatcat cacgccggtg tactgcactg      180

gggtgtcagc ccaagtgcag aagcagcggg ccagggagct gggcctgggc cgccatgaga      240

atgccatcaa gtacctgggc caggattatg agcagctgcg ggtgcgatgc ctgcagagtg      300

ggaccctctt ccgtgatgag gccttccccc cggtacccca gagcctgggt tacaaggacc      360

tgggtcccaa ttcctccaag acctatggca tcaagtggaa gcgtcccacg gaactgctgt      420

caaaccccca gttcattgtg gatggagcta cccgcacaga catctgccag ggagcactgg      480

gggactgctg gctcttggcg gccattgcct ccctcactct caacgacacc ctcctgcacc      540

gagtggttcc gcacggccag agcttccaga atggctatgc cggcatcttc catttccagc      600

tgtggcaatt tggggagtgg gtggacgtgg tcgtggatga cctgctgccc atcaaggacg      660

ggaagctagt gttcgtgcac tctgccgaag gcaacgagtt ctggagcgcc ctgcttgaga      720

aggcctatgc caaggtaaat ggcagctacg aggccctgtc agggggcagc acctcagagg      780

gctttgagga cttcacaggc ggggttaccg agtggtacga gttgcgcaag gctcccagtg      840

acctctacca gatcatcctc aaggcgctgg agcggggctc cctgctgggc tgctccatag      900

acatctccag cgttctagac atggaggcca tcactttcaa gaagttggtg aagggccatg      960

cctactctgt gaccggggcc aagcaggtga actaccgagg ccaggtggtg agcctgatcc     1020

ggatgcggaa cccctggggc gaggtggagt ggacgggagc ctggagcgac agctcctcag     1080

agtggaacaa cgtggaccca tatgaacggg accagctccg ggtcaagatg gaggacgggg     1140

agttctggat gtcattccga gacttcatgc gggagttcac ccgcctggag atctgcaacc     1200

tcacacccga cgccctcaag agccggacca tccgcaaatg gaacaccaca ctctacgaag     1260

gcacctggcg gcgggggagc accgcggggg gctgccgaaa ctacccagcc accttctggg     1320

tgaaccctca gttcaagatc cggctggatg agacggatga cccggacgac tacggggacc     1380

gcgagtcagg ctgcagcttc gtgctcgccc ttatgcagaa gcaccgtcgc cgcgagcgcc     1440

gcttcggccg cgacatggag actattggct tcgcggtcta cgaggtccct ccggagctgg     1500

tgggccagcc ggccgtacac ttgaagcgtg acttcttcct ggccaatgcg tctcgggcgc     1560

gctcagagca gttcatcaac ctgcgagagg tcagcacccg cttccgcctg ccacccgggg     1620

agtatgtggt ggtgccctcc accttcgagc ccaacaagga gggcgacttc gtgctgcgct     1680

tcttctcaga gaagagtgct gggactgtgg agctggatga ccagatccag gccaatctcc     1740

ccgatgagca agtgctctca gaagaggaga ttgacgagaa cttcaaggcc ctcttcaggc     1800

agctggcagg ggaggacatg gagatcagcg tgaaggagtt gcggacaatc ctcaatagga     1860

tcatcagcaa acacaaagac ctgcggacca agggcttcag cctagagtcg tgccgcagca     1920

tggtgaacct catggatcgt gatggcaatg ggaagctggg cctggtggag ttcaacatcc     1980

tgtggaaccg catccggaat tacctgtcca tcttccggaa gtttgacctg gacaagtcgg     2040

gcagcatgag tgcctacgag atgcggatgg ccattgagtc ggcaggcttc aagctcaaca     2100

agaagctgta cgagctcatc atcacccgct actcggagcc cgacctggcg gtcgactttg     2160

acaatttcgt ttgctgcctg gtgcggctag agaccatgtt ccgatttttc aaaactctgg     2220

acacagatct ggatggagtt gtgacctttg acttgtttaa gtggttgcag ctgaccatgt     2280

ttgcatgagg cagggactcg gtcccccttg ccgtgctccc ctccctcctc gtctgccaag     2340

cctcgcctcc taccacacca caccaggcca ccccagctgc aagtgccttc cttggagcag     2400

agaggcagcc tcgtcctcct gtcccctctc ctcccagcca ccatcgttca tctgctccgg     2460

gcagaactgt gtggcccctg cctgtgccag ccatgggctc gggatggact ccctgggccc     2520

cacccattgc caagccagga aggcagcttt cgcttgttcc tgcctcggga cagccccggg     2580

tttccccagc atcctgatgt gtcccctctc cccacttcag aggccaccca ctcagcacca     2640

ccggcctggc cttgcctgca gactataaac tataaccact agctcgacac agtctgcagt     2700

ccaggcgtgt ggagccgcct cccggctcgg ggaggccccg gggctgggaa cgcctgtgcc     2760

ttcctgcgcc gaagccaacg ccccctctgt ccttccctgg ccctgctgcc gaccaggagc     2820

tgcccagcct gtgggcggtc ggccttccct ccttcgctcc ttttttatat tagtgatttt     2880

aaaggggact cttcagggac ttgtgtactg gttatggggg tgccagaggc actaggcttg     2940

gggtggggag gtcccgtgtt ccatatagag gaaccccaaa taataaaagg ccccacatct     3000

gtctgtg                                                               3007


<210>  39
<211>  1492
<212>  DNA
<213>  Homo sapiens calpain, small subunit

<400>  39
cgggcgacag cagggccgcg gtgcagtgtc cgacccgaga gttgcggcct gagtcaccgg       60

ccccgccctc cggagccgga cgctgcggga ggcccgggag cggcagtgga accgactccc      120

agaactccgg acgtgtgcgg cgcagtgagt cgcagccatg ttcctggtta actcgttctt      180

gaagggcggc ggcggcggcg gcgggggagg cgggggcctg ggtgggggcc tgggaaatgt      240

gcttggaggc ctgatcagcg gggccggggg cggcggcggc ggcggcggcg gcggcggcgg      300

tggtggaggc ggcggtggcg gtggaacggc catgcgcatc ctaggcggag tcatcagcgc      360

catcagcgag gcggctgcgc agtacaaccc ggagcccccg cccccacgca cacattactc      420

caacattgag gccaacgaga gtgaggaggt ccggcagttc cggagactct ttgcccagct      480

ggctggagat gacatggagg tcagcgccac agaactcatg aacattctca ataaggttgt      540

gacacgacac cctgatctga agactgatgg ttttggcatt gacacatgtc gcagcatggt      600

ggccgtgatg gatagcgaca ccacaggcaa gctgggcttt gaggaattca agtacttgtg      660

gaacaacatc aaaaggtggc aggccatata caaacagttc gacactgacc gatcagggac      720

catttgcagt agtgaactcc caggtgcctt tgaggcagca gggttccacc tgaatgagca      780

tctctataac atgatcatcc gacgctactc agatgaaagt gggaacatgg attttgacaa      840

cttcatcagc tgcttggtca ggctggacgc catgttccgt gccttcaaat ctcttgacaa      900

agatggcact ggacaaatcc aggtgaacat ccaggagtgg ctgcagctga ctatgtattc      960

ctgaactgga gccccagacc cgccccctca ctgccttgct ataggagtca cctggagcct     1020

cggtctctcc cagggccgat cctgtctgca gtcacatctt tgtggggcct gctgacccac     1080

aagcttttgt tctctcagta cttgttaccc agcttctcaa catccagggc ccaatttgcc     1140

ctgcctggag ttccccctgg ctctaggaca ctctaacaag ctctgtccac gggtctcccc     1200

attcccacca ggccctgcac acacccactc cgtaacctct cccctgtacc tgtgccaagc     1260

ctagcacttg tgatgcctcc atgccccgag ggccctctct cagttctggg aggatgactc     1320

cagtccctgc acgccctggc acacccttca cggttgctac ccaggcggcc aagctccaga     1380

ccgtgccaga cccaggtgcc ccagtgcctt tgtctatatt ctgctcccag cctgccaggc     1440

ccaggaggaa ataaacatgc cccagttgct gatctctaaa aaaaaaaaaa aa             1492


<210>  40
<211>  2849
<212>  DNA
<213>  Homo sapiens calcium kinase 2, alpha subunit

<400>  40
cccgcctcct ggtaggaggg ggtttccgct tccggcagca gcggctgcag cctcgctctg       60

gtccctgcgg ctggcggccg agccgtgtgt ctcctcctcc atcgccgcca tattgtctgt      120

gtgagcagag gggagagcgg ccgccgccgc tgccgcttcc accacagctc tatcaaggct      180

tgtcaagcag tgtgctcatc acatggtaaa tcatgcagcg tggaacctca taaaatctcc      240

aagaaacatc attcacccat actgactagt ttcacatctc tttgtttgaa gaaaacaggt      300

ctgaaacaag gtcttacccc cagctgcttc tgaacacagt gactgccaga tctccaaaca      360

tcaagtccag ctttgtccgc caacctgtct gacatgtcgg gacccgtgcc aagcagggcc      420

agagtttaca cagatgttaa tacacacaga cctcgagaat actgggatta cgagtcacat      480

gtggtggaat ggggaaatca agatgactac cagctggttc gaaaattagg ccgaggtaaa      540

tacagtgaag tatttgaagc catcaacatc acaaataatg aaaaagttgt tgttaaaatt      600

ctcaagccag taaaaaagaa gaaaattaag cgtgaaataa agattttgga gaatttgaga      660

ggaggtccca acatcatcac actggcagac attgtaaaag accctgtgtc acgaaccccc      720

gccttggttt ttgaacacgt aaacaacaca gacttcaagc aattgtacca gacgttaaca      780

gactatgata ttcgatttta catgtatgag attctgaagg ccctggatta ttgtcacagc      840

atgggaatta tgcacagaga tgtcaagccc cataatgtca tgattgatca tgagcacaga      900

aagctacgac taatagactg gggtttggct gagttttatc atcctggcca agaatataat      960

gtccgagttg cttcccgata cttcaaaggt cctgagctac ttgtagacta tcagatgtac     1020

gattatagtt tggatatgtg gagtttgggt tgtatgctgg caagtatgat ctttcggaag     1080

gagccatttt tccatggaca tgacaattat gatcagttgg tgaggatagc caaggttctg     1140

gggacagaag atttatatga ctatattgac aaatacaaca ttgaattaga tccacgtttc     1200

aatgatatct tgggcagaca ctctcgaaag cgatgggaac gctttgtcca cagtgaaaat     1260

cagcaccttg tcagccctga ggccttggat ttcctggaca aactgctgcg atatgaccac     1320

cagtcacggc ttactgcaag agaggcaatg gagcacccct atttctacac tgttgtgaag     1380

gaccaggctc gaatgggttc atctagcatg ccagggggca gtacgcccgt cagcagcgcc     1440

aatatgatgt cagggatttc ttcagtgcca accccttcac cccttggacc tctggcaggc     1500

tcaccagtga ttgctgctgc caaccccctt gggatgcctg ttccagctgc cgctggcgct     1560

cagcagtaac ggccctatct gtctcctgat gcctgagcag aggtggggga gtccaccctc     1620

tccttgatgc agcttgcgcc tggcggggag gggtgaaaca cttcagaagc accgtgtctg     1680

aaccgttgct tgtggattta tagtagttca gtcataaaaa aaaaattata ataggctgat     1740

tttctttttt cttttttttt ttaactcgaa cttttcataa ctcaggggat tccctgaaaa     1800

attacctgca ggtggaatat ttcatggaca aatttttttt tctcccctcc caaatttagt     1860

tcctcatcac aaaagaacaa agataaacca gcctcaatcc cggctgctgc atttaggtgg     1920

agacttcttc ccattcccac cattgttcct ccaccgtccc acactttagg gggttggtat     1980

ctcgtgctct tctccagaga ttacaaaaat gtagcttctc aggggaggca ggaagaaagg     2040

aaggaaggaa agaaggaagg gaggacccaa tctataggag cagtggactg cttgctggtc     2100

gcttacatca ctttactcca taagcgcttc agtggggtta tcctagtggc tcttgtggaa     2160

gtgtgtctta gttacatcaa gatgttgaaa atctacccaa aatgcagaca gatactaaaa     2220

acttctgttc agtaagaatc atgtcttact gatctaaccc taaatccaac tcatttatac     2280

ttttattttt agttcagttt aaaatgttga taccttccct cccaggctcc ttaccttggt     2340

cttttccctg ttcatctccc aacatgctgt gctccatagc tggtaggaga gggaaggcaa     2400

aatctttctt agttttcttt gtcttggcca ttttgaattc atttagttac tgggcataac     2460

ttactgcttt ttacaaaaga aacaaacatt gtctgtacag gtttcatgct agagctaatg     2520

ggagatgtgg ccacactgac ttccatttta agctttctac cttcttttcc tccgaccgtc     2580

cccttccctc acatgccatc cagtgagaag acctgctcct cagtcttgta aatgtatctt     2640

gagaggtagg agcagagcca ctatctccat tgaagctgaa atggtagacc tgtaattgtg     2700

ggaaaactat aaactctctt gttacagccc cgccacccct tgctgtgtgt atatatataa     2760

tactttgtcc ttcatatgtg aaagatccag tgttggaatt ctttggtgta aataaacgtt     2820

tggttttatt tatcaaaaaa aaaaaaaaa                                       2849


<210>  41
<211>  1674
<212>  DNA
<213>  Homo sapiens calcium  kinase 2, alpha prime subunit

<400>  41
gcggccgccc gccgccgcgc tcctcctcct cctcctccag cgcccggcgg cccgctgcct       60

cctccgcccg acgccccgcg tcccccgccg cgccgccgcc gccaccctct gcgccccgcg      120

ccgccccccg gtcccgcccg ccatgcccgg cccggccgcg ggcagcaggg cccgggtcta      180

cgccgaggtg aacagtctga ggagccgcga gtactgggac tacgaggctc acgtcccgag      240

ctggggtaat caagatgatt accaactggt tcgaaaactt ggtcggggaa aatatagtga      300

agtatttgag gccattaata tcaccaacaa tgagagagtg gttgtaaaaa tcctgaagcc      360

agtgaagaaa aagaagataa aacgagaggt taagattctg gagaaccttc gtggtggaac      420

aaatatcatt aagctgattg acactgtaaa ggaccccgtg tcaaagacac cagctttggt      480

atttgaatat atcaataata cagattttaa gcaactctac cagatcctga cagactttga      540

tatccggttt tatatgtatg aactacttaa agctctggat tactgccaca gcaagggaat      600

catgcacagg gatgtgaaac ctcacaatgt catgatagat caccaacaga aaaagctgcg      660

actgatagat tggggtctgg cagaattcta tcatcctgct caggagtaca atgttcgtgt      720

agcctcaagg tacttcaagg gaccagagct cctcgtggac tatcagatgt atgattatag      780

cttggacatg tggagtttgg gctgtatgtt agcaagcatg atctttcgaa gggaaccatt      840

cttccatgga caggacaact atgaccagct tgttcgcatt gccaaggttc tgggtacaga      900

agaactgtat gggtatctga agaagtatca catagaccta gatccacact tcaacgatat      960

cctgggacaa cattcacgga aacgctggga aaactttatc catagtgaga acagacacct     1020

tgtcagccct gaggccctag atcttctgga caaacttctg cgatacgacc atcaacagag     1080

actgactgcc aaagaggcca tggagcaccc atacttctac cctgtggtga aggagcagtc     1140

ccagccttgt gcagacaatg ctgtgctttc cagtggtctc acggcagcac gatgaagact     1200

ggaaagcgac gggtctgttg cggttctccc acttttccat aagcagaaca agaaccaaat     1260

caaacgtctt aacgcgtata gagagatcac gttccgtgag cagacacaaa acggtggcag     1320

gtttggcgag cacgaactag accaagcgaa gggcagccca ccaccgtata tcaaacctca     1380

cttccgaatg taaaaggctc acttgccttt ggcttcctgt tgacttcttc ccgacccaga     1440

aagcatgggg aatgtgaagg gtatgcagaa tgttgttggt tactgttgct ccccgagccc     1500

ctcaactcgt cccgtggccg cctgtttttc cagcaaacca cgctaactag ctgaccacag     1560

actccacagt ggggggacgg gcgcagtatg tggcatggcg gcagttacat attattattt     1620

taaaagtata tattattgaa taaaaggttt taaaagaaaa aaaaaaaaaa aaaa           1674


<210>  42
<211>  1128
<212>  DNA
<213>  Homo sapiens calcium kinase 2, beta subunit

<400>  42
gcttctcgtt gtgccccgcc cgcaagcgcc ctcctccggg ccttcgtgac agccaggtcg       60

tgcgcgggtc atcctgggat tggtagttcg ctttctctca tttagccagt ttctttctct      120

accggggact ccgtgtcccg gcatccaccg cggcacctga cccttggcgc ttgcgtgttg      180

ccctcttccc caccctccct aatttccact ccccccaccc cacttcgcct gccgcggtcg      240

ggtccgcggc ctgcgctgta gcggtcgccg ccgttccctg gaagtagcaa cttccctacc      300

ccaccccagt cctggtcccc gtccagccgc tgacgtgaag atgagcagct cagaggaggt      360

gtcctggatt tcctggttct gtgggctccg tggcaatgaa ttcttctgtg aagtggatga      420

agactacatc caggacaaat ttaatcttac tggactcaat gagcaggtcc ctcactaccg      480

acaagctcta gacatgatct tggacctgga gcctgatgaa gaactggaag acaaccccaa      540

ccagagtgac ctgattgagc aggcagccga gatgctttat ggattgatcc acgcccgcta      600

catccttacc aaccgtggca tcgcccagat gttggaaaag taccagcaag gagactttgg      660

ttactgtcct cgtgtgtact gtgagaacca gccaatgctt cccattggcc tttcagacat      720

cccaggtgaa gccatggtga agctctactg ccccaagtgc atggatgtgt acacacccaa      780

gtcatcaaga caccatcaca cggatggcgc ctacttcggc actggtttcc ctcacatgct      840

cttcatggtg catcccgagt accggcccaa gagacctgcc aaccagtttg tgcccaggct      900

ctacggtttc aagatccatc cgatggccta ccagctgcag ctccaagccg ccagcaactt      960

caagagccca gtcaagacga ttcgctgatt ccctccccca cctgtcctgc agtctttgac     1020

ttttcctttc ttttttgcca ccctttcagg aaccctgtat ggtttttagt ttaaattaaa     1080

ggagtcgtta ttgtggtggg aatatgaaat aaagtagaag aaaaggcc                  1128


<210>  43
<211>  2643
<212>  DNA
<213>  Homo sapiens protein phosphatase 2, catalytic subunit, alpha isozyme

<400>  43
gcttcagtta ccagccggct acgtcgcgcc tgcgctttga cccccagttt gcgccccaac       60

tccggtcgtg cggccgcccg gggagggctc tgcagttgcg cagcttgctc cccggccctt      120

ttcccctccg ctccccgccg cctcctgacg ccgggcgtga cgtcaccacg cccggcggcc      180

gccattacag agagccgagc tctggagcct cagcgagcgg aggaggaggc gcagcggccg      240

acggccgagt actgcggtga gagccagcgg gccagcgcca gcctcaacag ccgccagaag      300

tacacgagga accggcggcg gcgtgtgcgt gtaggcccgt gtgcgggcgg cggcgcggga      360

gcagcgcgga gcggcagccg gctggggcgg gtggcatcat ggacgagaag gtgttcacca      420

aggagctgga ccagtggatc gagcagctga acgagtgcaa gcagctgtcc gagtcccagg      480

tcaagagcct ctgcgagaag gctaaagaaa tcctgacaaa agaatccaac gtgcaagagg      540

ttcgatgtcc agttactgtc tgtggagatg tgcatgggca atttcatgat ctcatggaac      600

tgtttagaat tggtggcaaa tcaccagata caaattactt gtttatggga gattatgttg      660

acagaggata ttattcagtt gaaacagtta cactgcttgt agctcttaag gttcgttacc      720

gtgaacgcat caccattctt cgagggaatc atgagagcag acagatcaca caagtttatg      780

gtttctatga tgaatgttta agaaaatatg gaaatgcaaa tgtttggaaa tattttacag      840

atctttttga ctatcttcct ctcactgcct tggtggatgg gcagatcttc tgtctacatg      900

gtggtctctc gccatctata gatacactgg atcatatcag agcacttgat cgcctacaag      960

aagttcccca tgagggtcca atgtgtgact tgctgtggtc agatccagat gaccgtggtg     1020

gttggggtat atctcctcga ggagctggtt acacctttgg gcaagatatt tctgagacat     1080

ttaatcatgc caatggcctc acgttggtgt ctagagctca ccagctagtg atggagggat     1140

ataactggtg ccatgaccgg aatgtagtaa cgattttcag tgctccaaac tattgttatc     1200

gttgtggtaa ccaagctgca atcatggaac ttgacgatac tctaaaatac tctttcttgc     1260

agtttgaccc agcacctcgt agaggcgagc cacatgttac tcgtcgtacc ccagactact     1320

tcctgtaatg aaattttaaa cttgtacagt attgccatga accatatatc gacctaatgg     1380

aaatgggaag agcaacagta actccaaagt gtcagaaaat agttaacatt caaaaaactt     1440

gttttcacat ggaccaaaag atgtgccata taaaaataca aagcctcttg tcatcaacag     1500

ccgtgaccac tttagaatga accagttcat tgcatgctga agcgacattg ttggtcaaga     1560

aaccagtttc tggcatagcg ctatttgtag ttacttttgc tttctctgag agactgcaga     1620

taataagatg taaacattaa cacctcgtga atacaattta acttccattt agctatagct     1680

ttactcagca tgactgtaga taaggatagc agcaaacaat cattggagct taatgaacat     1740

ttttaaaaat aattaccaag gcctcccttc tacttgtgag ttttgaaatt gttcttttta     1800

ttttcaggga taccgtttaa tttaattata tgatttgtct gcactcagtt tattccctac     1860

tcaaatctca gccccatgtt gttctttgtt attgtcagaa cctggtgagt tgttttgaac     1920

agaactgttt tttccccttc ctgtaagacg atgtgactgc acaagagcac tgcagtgttt     1980

ttcataataa acttgtgaac taagaactga gaaggtcaaa ttttaattgt atcaatgggc     2040

aagactggtg ctgtttatta aaaaagttaa atcaattgag taaattttag aatttgtaga     2100

cttgtaggta aaataaaaat caagggcact acataacctc tctggtaact ccttgacatt     2160

cttcagatta acttcaggat ttatttgtat ttcacatatt acaatttgtc acattgttgg     2220

tgtgcacttt gtgggttctt cctgcatatt aacttgtttg taagaaagga aatctgtgct     2280

gcttcagtaa gacttaattg taaaaccata taacttgaga tttaagtctt tgggttttgt     2340

tttaataaaa cagcatgttt tcaggtagag cttaaactaa atgatgtgtt tacttagtgc     2400

agtttctggt tatgaatatt atattgctat gtgtatatta tatggactct ttaaaatgat     2460

tgacagattg gcaaattctt aaatctttgt acattgttga gtcatatgtt cttagagtta     2520

aatttgtctc agataagaaa gtgttaaagc attagcctgt gtcaagttct ttgagtgata     2580

ctagtgaaac caaatagaaa actattgttg gatcatgatt tagtcttatg tacattcacc     2640

cga                                                                   2643


<210>  44
<211>  3945
<212>  DNA
<213>  Homo sapiens protein phosphatase 2, regulatory subunit B, alpha

<400>  44
aggtgacgtc actggccagg ccagccggcg ccattttgaa agtggagtcg cctgcccctg       60

ccgctgccgc cgccgccgtc gctgtcgtag tcgccgccgc cgctgccgga gaaagagcac      120

gagcggggaa gccccagagt gaaatctagc atcctgccgg ctggtctgcc cgcccctcct      180

tccttttccc cccggccccc gtcccctccc cccgcaggtg ccatccgccg ccatccgccc      240

tctctacccc cccatcccca ggtgaggggg gtgagttcag gaagcggaga ccccgaggaa      300

cccagcaggg tcaccatttg cagcgcaaca tggcaggagc tggaggaggg aatgatattc      360

agtggtgttt ttctcaggtg aaaggagcag tagatgatga tgtagcagaa gcagatataa      420

tttctacagt agaatttaat cattctggag aattactagc aacaggagat aaaggtggta      480

gagttgtcat ctttcaacag gagcaggaga acaaaatcca gtctcatagc agaggagaat      540

ataatgttta cagcaccttc cagagccatg aaccagagtt tgactacttg aaaagtttag      600

aaatagaaga aaagatcaac aaaattaggt ggttacccca gaaaaatgct gctcagtttt      660

tattgtctac caatgataaa acaataaaat tatggaaaat cagtgaaagg gacaaaagac      720

cagaagggta taacttgaaa gaggaggatg gaaggtatag agatcctact acagttacta      780

cactacgagt gccagtcttt aggcctatgg atctaatggt tgaggccagt ccacgaagaa      840

tatttgccaa tgctcataca tatcacatca actcaatttc tattaatagt gattatgaaa      900

catatttatc tgcagatgat ttgcggatta atctttggca tctggaaatt acagacagga      960

gttttaacat tgtggatatc aagcctgcca atatggaaga gctaacagag gtgattacag     1020

cagcagaatt tcatccaaac agctgtaaca catttgtata cagcagcagt aaaggaacta     1080

ttcggctatg tgacatgagg gcatctgccc tctgtgatag acattctaaa ttgtttgaag     1140

aacctgaaga tcccagtaac aggtcatttt tttccgaaat catctcctct atttcggatg     1200

taaaattcag ccatagtggt cgatatatga tgactagaga ctatttgtca gtcaaaattt     1260

gggacttaaa tatggaaaac aggcctgtgg aaacatacca ggtgcatgaa tacctcagaa     1320

gtaaactctg ttcactgtat gaaaatgact gcatatttga caaatttgaa tgttgttgga     1380

atggatctga cagtgttgtc atgactggat cttacaataa tttcttcaga atgtttgaca     1440

gaaacacaaa gcgagacata accctagaag catcgcggga aaacaataag cctcgcacag     1500

ttctgaagcc tcgcaaagtc tgtgcaagtg gcaagcgaaa gaaagatgaa ataagtgttg     1560

acagcctaga cttcaataag aaaatccttc acacagcctg gcaccccaag gaaaatatca     1620

ttgccgtagc tactacaaac aatctgtata tatttcaaga caaagtgaat tagggttggc     1680

attcctagca gaagaaccca cttcctgctt agttgagata gttgaatcta gcattcgttc     1740

ctataaaaga gagaggtcca ttgtggcgcc cctttccagt gtttgacagt gtgccattcg     1800

acaacacatt gttatagcta catggagaaa gctctgtgga ttcatcactg tggtgttctc     1860

catgtctgct agccatttag gtaagggtag ggcactttta atttaaatga cttcttgcac     1920

catcttgcct aatggactag attggactgt atcaacattg atttactcca ctttttatgc     1980

cttccattgt gatgacgtca aacacagtga aagccttcag tcatgctatg ggatttaatt     2040

gtgtatcctc attactgtat catttgtggg gtacacccct tccccctttt tttaaattaa     2100

atacagctca ttcttactgt ggcttgtagc attcctcctc ttctggcctc ctggactgct     2160

ccccttcatc tcttaccctt gccccctcca cccggtcttg gtggtggtat attaaaaaaa     2220

gaaagaatga aagcacacaa aatgagtcag tttggggtca gtggtataaa gggggtatat     2280

gttgcaaaca aatgttttag taacagttgg ctgtaatcac tcctcgccgt gtctggcact     2340

gaaaataagg aaaaaaaacc tactactgaa taaaagtgac aaagaatgga gaatctggtt     2400

ttctttttct ttttaaccta cctcttgtag ccaatatttt gtgtcatacc tttgggcaca     2460

gtgaaacaaa atgggttttc attgtttatt ggtatttttg ttaattattt ttaacaagtg     2520

ttcttttaca tgcaggagga gaggtattgg ttctctatga acatattttg aatataggtt     2580

ttattaagga tttcacaatc tataaatgct actagttttt tttttttttt ttaccatcat     2640

gagggtattg gatacattgt gtctctattt aactcattat gtgttaatga aattgttgta     2700

aatgggaacc aaatttgtag aacttaattt ctacttttta gagtgcttaa tttcattttt     2760

gccttactaa atagtcaaag acttataaaa catttttaac aagttagaac ttttttgtta     2820

ttcagtcata taaaatagca gaaaactaac atcaagtgac actgcactaa atactttttt     2880

tgtattttac tgctatcaaa tcagaatgaa atatacttta ccatagatat ttttcttcta     2940

tttttggttt tccaaagcta tatgaaagac aaatttttaa aggtacagcg ttcaaaaagt     3000

gcttaatgaa ctccaacagc tgcctcaaat aaaaatctgt atatgaatac attttcccta     3060

agcggtgata cattatccaa agatgaagag tgctcctatt tttaataggt agaatgtacc     3120

tttgtcagtc ttgcagaaac tttaatggag aagaaatgga ctttattttt gaaaggtgaa     3180

atgaacaggc atttatatta ttagagaatg gtagtcttat tttggtggaa cataatgtaa     3240

caaccttgaa tttcagagga ctctgagtgc ttctatgtcc actacctatt gttctattct     3300

tcaataatga aaaagaattc aacgagccga ccgtgattcc ctctactaca aatattatgt     3360

cttgtaagtt agcattttta gcacacagga gaaattttat gtaataaaat tactgtatct     3420

tttggattta acaaatttgt atttgaaaca cattctatgt ctgataattc ttaatggcac     3480

ttttactaat ttatttgggg atcttgggta cattcttaat ttgtgtttat tcttcacgct     3540

tgacttgcaa gtgggatatt cccctgccac aagtgtcaaa cagtgatatt cttcctgtgt     3600

tgtgactgga cagttttcca gatctttttt gggagatttt cctacagctt ggttgtatgt     3660

cttgagataa caccaccaaa cagctctcag aaattctttt ttgattgatc agtagctatg     3720

atgattctcc tccatgacac taaggattag tttatatatt taagagaaat aattgctaaa     3780

attaaaatgc ctctatcaag gaatgctatt ataaattatt gttaacattc tcaagtatta     3840

attttttaat ttcattggtg tagcaaactc taagcccagc cactcatttt acatggccat     3900

ggttaatctt tttattaata aaaattatac ttagaataaa aaaaa                     3945


<210>  45
<211>  2519
<212>  DNA
<213>  Homo sapiens protein phosphatase 2, regulatory subunit A, alpha

<400>  45
aatcttggtc gctaggacac ggctaacttc cgctttcttc cccctctcct aggctcaaac       60

tagtcaaatc ttgttcactc gaccaatggc aaatcggaag tgggcgggac ttcacaagtc      120

cggaccaaag aaacgcgagc ttagccctgg gtagcgcggc caatggccgt ggagcagccc      180

ctgtaaactg gctcgggcgc ccccacgccc gcccttcctt cttctcccag cattgccccc      240

cccacgtttc agcacagcgc tggccgcagt ctgacaggaa agggacggag ccaagatggc      300

ggcggccgac ggcgacgact cgctgtaccc catcgcggtg ctcatagacg aactccgcaa      360

tgaggacgtt cagcttcgcc tcaacagcat caagaagctg tccaccatcg ccttggccct      420

tggggttgaa aggacccgaa gtgagcttct gcctttcctt acagatacca tctatgatga      480

agatgaggtc ctcctggccc tggcagaaca gctgggaacc ttcactaccc tggtgggagg      540

cccagagtac gtgcactgcc tgctgccacc gctggagtcg ctggccacag tggaggagac      600

agtggtgcgg gacaaggcag tggagtcctt acgggccatc tcacacgagc actcgccctc      660

tgacctggag gcgcactttg tgccgctagt gaagcggctg gcgggcggcg actggttcac      720

ctcccgcacc tcggcctgcg gcctcttctc cgtctgctac ccccgagtgt ccagtgctgt      780

gaaggcggaa cttcgacagt acttccggaa cctgtgctca gatgacaccc ccatggtgcg      840

gcgggccgca gcctccaagc tgggggagtt tgccaaggtg ctggagctgg acaacgtcaa      900

gagtgagatc atccccatgt tctccaacct ggcctctgac gagcaggact cggtgcggct      960

gctggcggtg gaggcgtgcg tgaacatcgc ccagcttctg ccccaggagg atctggaggc     1020

cctggtgatg cccactctgc gccaggccgc tgaagacaag tcctggcgcg tccgctacat     1080

ggtggctgac aagttcacag agctccagaa agcagtgggg cctgagatca ccaagacaga     1140

cctggtccct gccttccaga acctgatgaa agactgtgag gccgaggtga gggccgcagc     1200

ctcccacaag gtcaaagagt tctgtgaaaa cctctcagct gactgtcggg agaatgtgat     1260

catgtcccag atcttgccct gcatcaagga gctggtgtcc gatgccaacc aacatgtcaa     1320

gtctgccctg gcctcagtca tcatgggtct ctctcccatc ttgggcaaag acaacaccat     1380

cgagcacctc ttgcccctct tcctggctca gctgaaggat gagtgccctg aggtacggct     1440

gaacatcatc tctaacctgg actgtgtgaa cgaggtgatt ggcatccggc agctgtccca     1500

gtccctgctc cctgccattg tggagctggc tgaggacgcc aagtggcggg tgcggctggc     1560

catcattgag tacatgcccc tcctggctgg acagctggga gtggagttct ttgatgagaa     1620

acttaactcc ttgtgcatgg cctggcttgt ggatcatgta tatgccatcc gcgaggcagc     1680

caccagcaac ctgaagaagc tagtggaaaa gtttgggaag gagtgggccc atgccacaat     1740

catccccaag gtcttggcca tgtccggaga ccccaactac ctgcaccgca tgactacgct     1800

cttctgcatc aatgtgctgt ctgaggtctg tgggcaggac atcaccacca agcacatgct     1860

acccacggtt ctgcgcatgg ctggggaccc ggttgccaat gtccgcttca atgtggccaa     1920

gtctctgcag aagatagggc ccatcctgga caacagcacc ttgcagagtg aagtcaagcc     1980

catcctagag aagctgaccc aggaccagga tgtggacgtc aaatactttg cccaggaggc     2040

tctgactgtt ctgtctctcg cctgatgctg gaagaggagc aaacactggc ctctggtgtc     2100

caccctccaa cccccacaag tccctctttg gggagacact ggggggcctt tggctgtcac     2160

tccctgtgca tggtctgacc ccaggcccct tcccccagca cggttcctcc tctccccagc     2220

ctgggaagat gtctcactgt ccacctccca acgggctagg ggagcacggg gttggacagg     2280

acagtgacct tgggaggaag gggctactcc gcccacgtca gggagagatg tgagcatccc     2340

gggtcactgg atcctgctgc tgtaatggga acccctcccc catttacttc tccacctccc     2400

gtcctcccca tcattggttt ttttttgtgt gtcaactgtg ccgtttttat tttattcctt     2460

ttattttccc ccttttcaca gagaaataaa ggtctagaag tagttggtca aaaaaaaaa      2519


<210>  46
<211>  360
<212>  PRT
<213>  Homo sapiens P38

<400>  46

Met Ala Ala Ala Ala Ala Ala Gly Ala Gly Pro Glu Met Val Arg Gly 
1               5                   10                  15      


Gln Val Phe Asp Val Gly Pro Arg Tyr Thr Asn Leu Ser Tyr Ile Gly 
            20                  25                  30          


Glu Gly Ala Tyr Gly Met Val Cys Ser Ala Tyr Asp Asn Val Asn Lys 
        35                  40                  45              


Val Arg Val Ala Ile Lys Lys Ile Ser Pro Phe Glu His Gln Thr Tyr 
    50                  55                  60                  


Cys Gln Arg Thr Leu Arg Glu Ile Lys Ile Leu Leu Arg Phe Arg His 
65                  70                  75                  80  


Glu Asn Ile Ile Gly Ile Asn Asp Ile Ile Arg Ala Pro Thr Ile Glu 
                85                  90                  95      


Gln Met Lys Asp Val Tyr Ile Val Gln Asp Leu Met Glu Thr Asp Leu 
            100                 105                 110         


Tyr Lys Leu Leu Lys Thr Gln His Leu Ser Asn Asp His Ile Cys Tyr 
        115                 120                 125             


Phe Leu Tyr Gln Ile Leu Arg Gly Leu Lys Tyr Ile His Ser Ala Asn 
    130                 135                 140                 


Val Leu His Arg Asp Leu Lys Pro Ser Asn Leu Leu Leu Asn Thr Thr 
145                 150                 155                 160 


Cys Asp Leu Lys Ile Cys Asp Phe Gly Leu Ala Arg Val Ala Asp Pro 
                165                 170                 175     


Asp His Asp His Thr Gly Phe Leu Thr Glu Tyr Val Ala Thr Arg Trp 
            180                 185                 190         


Tyr Arg Ala Pro Glu Ile Met Leu Asn Ser Lys Gly Tyr Thr Lys Ser 
        195                 200                 205             


Ile Asp Ile Trp Ser Val Gly Cys Ile Leu Ala Glu Met Leu Ser Asn 
    210                 215                 220                 


Arg Pro Ile Phe Pro Gly Lys His Tyr Leu Asp Gln Leu Asn His Ile 
225                 230                 235                 240 


Leu Gly Ile Leu Gly Ser Pro Ser Gln Glu Asp Leu Asn Cys Ile Ile 
                245                 250                 255     


Asn Leu Lys Ala Arg Asn Tyr Leu Leu Ser Leu Pro His Lys Asn Lys 
            260                 265                 270         


Val Pro Trp Asn Arg Leu Phe Pro Asn Ala Asp Ser Lys Ala Leu Asp 
        275                 280                 285             


Leu Leu Asp Lys Met Leu Thr Phe Asn Pro His Lys Arg Ile Glu Val 
    290                 295                 300                 


Glu Gln Ala Leu Ala His Pro Tyr Leu Glu Gln Tyr Tyr Asp Pro Ser 
305                 310                 315                 320 


Asp Glu Pro Ile Ala Glu Ala Pro Phe Lys Phe Asp Met Glu Leu Asp 
                325                 330                 335     


Asp Leu Pro Lys Glu Lys Leu Lys Glu Leu Ile Phe Glu Glu Thr Ala 
            340                 345                 350         


Arg Phe Gln Pro Gly Tyr Arg Ser 
        355                 360 


<210>  47
<211>  384
<212>  PRT
<213>  Homo sapiens jnk

<400>  47

Met Ser Arg Ser Lys Arg Asp Asn Asn Phe Tyr Ser Val Glu Ile Gly 
1               5                   10                  15      


Asp Ser Thr Phe Thr Val Leu Lys Arg Tyr Gln Asn Leu Lys Pro Ile 
            20                  25                  30          


Gly Ser Gly Ala Gln Gly Ile Val Cys Ala Ala Tyr Asp Ala Ile Leu 
        35                  40                  45              


Glu Arg Asn Val Ala Ile Lys Lys Leu Ser Arg Pro Phe Gln Asn Gln 
    50                  55                  60                  


Thr His Ala Lys Arg Ala Tyr Arg Glu Leu Val Leu Met Lys Cys Val 
65                  70                  75                  80  


Asn His Lys Asn Ile Ile Gly Leu Leu Asn Val Phe Thr Pro Gln Lys 
                85                  90                  95      


Ser Leu Glu Glu Phe Gln Asp Val Tyr Ile Val Met Glu Leu Met Asp 
            100                 105                 110         


Ala Asn Leu Cys Gln Val Ile Gln Met Glu Leu Asp His Glu Arg Met 
        115                 120                 125             


Ser Tyr Leu Leu Tyr Gln Met Leu Cys Gly Ile Lys His Leu His Ser 
    130                 135                 140                 


Ala Gly Ile Ile His Arg Asp Leu Lys Pro Ser Asn Ile Val Val Lys 
145                 150                 155                 160 


Ser Asp Cys Thr Leu Lys Ile Leu Asp Phe Gly Leu Ala Arg Thr Ala 
                165                 170                 175     


Gly Thr Ser Phe Met Met Thr Pro Tyr Val Val Thr Arg Tyr Tyr Arg 
            180                 185                 190         


Ala Pro Glu Val Ile Leu Gly Met Gly Tyr Lys Glu Asn Val Asp Leu 
        195                 200                 205             


Trp Ser Val Gly Cys Ile Met Gly Glu Met Val Cys His Lys Ile Leu 
    210                 215                 220                 


Phe Pro Gly Arg Asp Tyr Ile Asp Gln Trp Asn Lys Val Ile Glu Gln 
225                 230                 235                 240 


Leu Gly Thr Pro Cys Pro Glu Phe Met Lys Lys Leu Gln Pro Thr Val 
                245                 250                 255     


Arg Thr Tyr Val Glu Asn Arg Pro Lys Tyr Ala Gly Tyr Ser Phe Glu 
            260                 265                 270         


Lys Leu Phe Pro Asp Val Leu Phe Pro Ala Asp Ser Glu His Asn Lys 
        275                 280                 285             


Leu Lys Ala Ser Gln Ala Arg Asp Leu Leu Ser Lys Met Leu Val Ile 
    290                 295                 300                 


Asp Ala Ser Lys Arg Ile Ser Val Asp Glu Ala Leu Gln His Pro Tyr 
305                 310                 315                 320 


Ile Asn Val Trp Tyr Asp Pro Ser Glu Ala Glu Ala Pro Pro Pro Lys 
                325                 330                 335     


Ile Pro Asp Lys Gln Leu Asp Glu Arg Glu His Thr Ile Glu Glu Trp 
            340                 345                 350         


Lys Glu Leu Ile Tyr Lys Glu Val Met Asp Leu Glu Glu Arg Thr Lys 
        355                 360                 365             


Asn Gly Val Ile Arg Gly Gln Pro Ser Pro Leu Ala Gln Val Gln Gln 
    370                 375                 380                 


<210>  48
<211>  536
<212>  PRT
<213>  Homo sapiens src

<400>  48

Met Gly Ser Asn Lys Ser Lys Pro Lys Asp Ala Ser Gln Arg Arg Arg 
1               5                   10                  15      


Ser Leu Glu Pro Ala Glu Asn Val His Gly Ala Gly Gly Gly Ala Phe 
            20                  25                  30          


Pro Ala Ser Gln Thr Pro Ser Lys Pro Ala Ser Ala Asp Gly His Arg 
        35                  40                  45              


Gly Pro Ser Ala Ala Phe Ala Pro Ala Ala Ala Glu Pro Lys Leu Phe 
    50                  55                  60                  


Gly Gly Phe Asn Ser Ser Asp Thr Val Thr Ser Pro Gln Arg Ala Gly 
65                  70                  75                  80  


Pro Leu Ala Gly Gly Val Thr Thr Phe Val Ala Leu Tyr Asp Tyr Glu 
                85                  90                  95      


Ser Arg Thr Glu Thr Asp Leu Ser Phe Lys Lys Gly Glu Arg Leu Gln 
            100                 105                 110         


Ile Val Asn Asn Thr Glu Gly Asp Trp Trp Leu Ala His Ser Leu Ser 
        115                 120                 125             


Thr Gly Gln Thr Gly Tyr Ile Pro Ser Asn Tyr Val Ala Pro Ser Asp 
    130                 135                 140                 


Ser Ile Gln Ala Glu Glu Trp Tyr Phe Gly Lys Ile Thr Arg Arg Glu 
145                 150                 155                 160 


Ser Glu Arg Leu Leu Leu Asn Ala Glu Asn Pro Arg Gly Thr Phe Leu 
                165                 170                 175     


Val Arg Glu Ser Glu Thr Thr Lys Gly Ala Tyr Cys Leu Ser Val Ser 
            180                 185                 190         


Asp Phe Asp Asn Ala Lys Gly Leu Asn Val Lys His Tyr Lys Ile Arg 
        195                 200                 205             


Lys Leu Asp Ser Gly Gly Phe Tyr Ile Thr Ser Arg Thr Gln Phe Asn 
    210                 215                 220                 


Ser Leu Gln Gln Leu Val Ala Tyr Tyr Ser Lys His Ala Asp Gly Leu 
225                 230                 235                 240 


Cys His Arg Leu Thr Thr Val Cys Pro Thr Ser Lys Pro Gln Thr Gln 
                245                 250                 255     


Gly Leu Ala Lys Asp Ala Trp Glu Ile Pro Arg Glu Ser Leu Arg Leu 
            260                 265                 270         


Glu Val Lys Leu Gly Gln Gly Cys Phe Gly Glu Val Trp Met Gly Thr 
        275                 280                 285             


Trp Asn Gly Thr Thr Arg Val Ala Ile Lys Thr Leu Lys Pro Gly Thr 
    290                 295                 300                 


Met Ser Pro Glu Ala Phe Leu Gln Glu Ala Gln Val Met Lys Lys Leu 
305                 310                 315                 320 


Arg His Glu Lys Leu Val Gln Leu Tyr Ala Val Val Ser Glu Glu Pro 
                325                 330                 335     


Ile Tyr Ile Val Thr Glu Tyr Met Ser Lys Gly Ser Leu Leu Asp Phe 
            340                 345                 350         


Leu Lys Gly Glu Thr Gly Lys Tyr Leu Arg Leu Pro Gln Leu Val Asp 
        355                 360                 365             


Met Ala Ala Gln Ile Ala Ser Gly Met Ala Tyr Val Glu Arg Met Asn 
    370                 375                 380                 


Tyr Val His Arg Asp Leu Arg Ala Ala Asn Ile Leu Val Gly Glu Asn 
385                 390                 395                 400 


Leu Val Cys Lys Val Ala Asp Phe Gly Leu Ala Arg Leu Ile Glu Asp 
                405                 410                 415     


Asn Glu Tyr Thr Ala Arg Gln Gly Ala Lys Phe Pro Ile Lys Trp Thr 
            420                 425                 430         


Ala Pro Glu Ala Ala Leu Tyr Gly Arg Phe Thr Ile Lys Ser Asp Val 
        435                 440                 445             


Trp Ser Phe Gly Ile Leu Leu Thr Glu Leu Thr Thr Lys Gly Arg Val 
    450                 455                 460                 


Pro Tyr Pro Gly Met Val Asn Arg Glu Val Leu Asp Gln Val Glu Arg 
465                 470                 475                 480 


Gly Tyr Arg Met Pro Cys Pro Pro Glu Cys Pro Glu Ser Leu His Asp 
                485                 490                 495     


Leu Met Cys Gln Cys Trp Arg Lys Glu Pro Glu Glu Arg Pro Thr Phe 
            500                 505                 510         


Glu Tyr Leu Gln Ala Phe Leu Glu Asp Tyr Phe Thr Ser Thr Glu Pro 
        515                 520                 525             


Gln Tyr Gln Pro Gly Glu Asn Leu 
    530                 535     


<210>  49
<211>  277
<212>  PRT
<213>  Homo sapiens caspase 3

<400>  49

Met Glu Asn Thr Glu Asn Ser Val Asp Ser Lys Ser Ile Lys Asn Leu 
1               5                   10                  15      


Glu Pro Lys Ile Ile His Gly Ser Glu Ser Met Asp Ser Gly Ile Ser 
            20                  25                  30          


Leu Asp Asn Ser Tyr Lys Met Asp Tyr Pro Glu Met Gly Leu Cys Ile 
        35                  40                  45              


Ile Ile Asn Asn Lys Asn Phe His Lys Ser Thr Gly Met Thr Ser Arg 
    50                  55                  60                  


Ser Gly Thr Asp Val Asp Ala Ala Asn Leu Arg Glu Thr Phe Arg Asn 
65                  70                  75                  80  


Leu Lys Tyr Glu Val Arg Asn Lys Asn Asp Leu Thr Arg Glu Glu Ile 
                85                  90                  95      


Val Glu Leu Met Arg Asp Val Ser Lys Glu Asp His Ser Lys Arg Ser 
            100                 105                 110         


Ser Phe Val Cys Val Leu Leu Ser His Gly Glu Glu Gly Ile Ile Phe 
        115                 120                 125             


Gly Thr Asn Gly Pro Val Asp Leu Lys Lys Ile Thr Asn Phe Phe Arg 
    130                 135                 140                 


Gly Asp Arg Cys Arg Ser Leu Thr Gly Lys Pro Lys Leu Phe Ile Ile 
145                 150                 155                 160 


Gln Ala Cys Arg Gly Thr Glu Leu Asp Cys Gly Ile Glu Thr Asp Ser 
                165                 170                 175     


Gly Val Asp Asp Asp Met Ala Cys His Lys Ile Pro Val Glu Ala Asp 
            180                 185                 190         


Phe Leu Tyr Ala Tyr Ser Thr Ala Pro Gly Tyr Tyr Ser Trp Arg Asn 
        195                 200                 205             


Ser Lys Asp Gly Ser Trp Phe Ile Gln Ser Leu Cys Ala Met Leu Lys 
    210                 215                 220                 


Gln Tyr Ala Asp Lys Leu Glu Phe Met His Ile Leu Thr Arg Val Asn 
225                 230                 235                 240 


Arg Lys Val Ala Thr Glu Phe Glu Ser Phe Ser Phe Asp Ala Thr Phe 
                245                 250                 255     


His Ala Lys Lys Gln Ile Pro Cys Ile Val Ser Met Leu Thr Lys Glu 
            260                 265                 270         


Leu Tyr Phe Tyr His 
        275         


<210>  50
<211>  714
<212>  PRT
<213>  Homo sapiens calpain 1, large subunit

<400>  50

Met Ser Glu Glu Ile Ile Thr Pro Val Tyr Cys Thr Gly Val Ser Ala 
1               5                   10                  15      


Gln Val Gln Lys Gln Arg Ala Arg Glu Leu Gly Leu Gly Arg His Glu 
            20                  25                  30          


Asn Ala Ile Lys Tyr Leu Gly Gln Asp Tyr Glu Gln Leu Arg Val Arg 
        35                  40                  45              


Cys Leu Gln Ser Gly Thr Leu Phe Arg Asp Glu Ala Phe Pro Pro Val 
    50                  55                  60                  


Pro Gln Ser Leu Gly Tyr Lys Asp Leu Gly Pro Asn Ser Ser Lys Thr 
65                  70                  75                  80  


Tyr Gly Ile Lys Trp Lys Arg Pro Thr Glu Leu Leu Ser Asn Pro Gln 
                85                  90                  95      


Phe Ile Val Asp Gly Ala Thr Arg Thr Asp Ile Cys Gln Gly Ala Leu 
            100                 105                 110         


Gly Asp Cys Trp Leu Leu Ala Ala Ile Ala Ser Leu Thr Leu Asn Asp 
        115                 120                 125             


Thr Leu Leu His Arg Val Val Pro His Gly Gln Ser Phe Gln Asn Gly 
    130                 135                 140                 


Tyr Ala Gly Ile Phe His Phe Gln Leu Trp Gln Phe Gly Glu Trp Val 
145                 150                 155                 160 


Asp Val Val Val Asp Asp Leu Leu Pro Ile Lys Asp Gly Lys Leu Val 
                165                 170                 175     


Phe Val His Ser Ala Glu Gly Asn Glu Phe Trp Ser Ala Leu Leu Glu 
            180                 185                 190         


Lys Ala Tyr Ala Lys Val Asn Gly Ser Tyr Glu Ala Leu Ser Gly Gly 
        195                 200                 205             


Ser Thr Ser Glu Gly Phe Glu Asp Phe Thr Gly Gly Val Thr Glu Trp 
    210                 215                 220                 


Tyr Glu Leu Arg Lys Ala Pro Ser Asp Leu Tyr Gln Ile Ile Leu Lys 
225                 230                 235                 240 


Ala Leu Glu Arg Gly Ser Leu Leu Gly Cys Ser Ile Asp Ile Ser Ser 
                245                 250                 255     


Val Leu Asp Met Glu Ala Ile Thr Phe Lys Lys Leu Val Lys Gly His 
            260                 265                 270         


Ala Tyr Ser Val Thr Gly Ala Lys Gln Val Asn Tyr Arg Gly Gln Val 
        275                 280                 285             


Val Ser Leu Ile Arg Met Arg Asn Pro Trp Gly Glu Val Glu Trp Thr 
    290                 295                 300                 


Gly Ala Trp Ser Asp Ser Ser Ser Glu Trp Asn Asn Val Asp Pro Tyr 
305                 310                 315                 320 


Glu Arg Asp Gln Leu Arg Val Lys Met Glu Asp Gly Glu Phe Trp Met 
                325                 330                 335     


Ser Phe Arg Asp Phe Met Arg Glu Phe Thr Arg Leu Glu Ile Cys Asn 
            340                 345                 350         


Leu Thr Pro Asp Ala Leu Lys Ser Arg Thr Ile Arg Lys Trp Asn Thr 
        355                 360                 365             


Thr Leu Tyr Glu Gly Thr Trp Arg Arg Gly Ser Thr Ala Gly Gly Cys 
    370                 375                 380                 


Arg Asn Tyr Pro Ala Thr Phe Trp Val Asn Pro Gln Phe Lys Ile Arg 
385                 390                 395                 400 


Leu Asp Glu Thr Asp Asp Pro Asp Asp Tyr Gly Asp Arg Glu Ser Gly 
                405                 410                 415     


Cys Ser Phe Val Leu Ala Leu Met Gln Lys His Arg Arg Arg Glu Arg 
            420                 425                 430         


Arg Phe Gly Arg Asp Met Glu Thr Ile Gly Phe Ala Val Tyr Glu Val 
        435                 440                 445             


Pro Pro Glu Leu Val Gly Gln Pro Ala Val His Leu Lys Arg Asp Phe 
    450                 455                 460                 


Phe Leu Ala Asn Ala Ser Arg Ala Arg Ser Glu Gln Phe Ile Asn Leu 
465                 470                 475                 480 


Arg Glu Val Ser Thr Arg Phe Arg Leu Pro Pro Gly Glu Tyr Val Val 
                485                 490                 495     


Val Pro Ser Thr Phe Glu Pro Asn Lys Glu Gly Asp Phe Val Leu Arg 
            500                 505                 510         


Phe Phe Ser Glu Lys Ser Ala Gly Thr Val Glu Leu Asp Asp Gln Ile 
        515                 520                 525             


Gln Ala Asn Leu Pro Asp Glu Gln Val Leu Ser Glu Glu Glu Ile Asp 
    530                 535                 540                 


Glu Asn Phe Lys Ala Leu Phe Arg Gln Leu Ala Gly Glu Asp Met Glu 
545                 550                 555                 560 


Ile Ser Val Lys Glu Leu Arg Thr Ile Leu Asn Arg Ile Ile Ser Lys 
                565                 570                 575     


His Lys Asp Leu Arg Thr Lys Gly Phe Ser Leu Glu Ser Cys Arg Ser 
            580                 585                 590         


Met Val Asn Leu Met Asp Arg Asp Gly Asn Gly Lys Leu Gly Leu Val 
        595                 600                 605             


Glu Phe Asn Ile Leu Trp Asn Arg Ile Arg Asn Tyr Leu Ser Ile Phe 
    610                 615                 620                 


Arg Lys Phe Asp Leu Asp Lys Ser Gly Ser Met Ser Ala Tyr Glu Met 
625                 630                 635                 640 


Arg Met Ala Ile Glu Ser Ala Gly Phe Lys Leu Asn Lys Lys Leu Tyr 
                645                 650                 655     


Glu Leu Ile Ile Thr Arg Tyr Ser Glu Pro Asp Leu Ala Val Asp Phe 
            660                 665                 670         


Asp Asn Phe Val Cys Cys Leu Val Arg Leu Glu Thr Met Phe Arg Phe 
        675                 680                 685             


Phe Lys Thr Leu Asp Thr Asp Leu Asp Gly Val Val Thr Phe Asp Leu 
    690                 695                 700                 


Phe Lys Trp Leu Gln Leu Thr Met Phe Ala 
705                 710                 


<210>  51
<211>  268
<212>  PRT
<213>  Homo sapiens calpain, small subunit

<400>  51

Met Phe Leu Val Asn Ser Phe Leu Lys Gly Gly Gly Gly Gly Gly Gly 
1               5                   10                  15      


Gly Gly Gly Gly Leu Gly Gly Gly Leu Gly Asn Val Leu Gly Gly Leu 
            20                  25                  30          


Ile Ser Gly Ala Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly 
        35                  40                  45              


Gly Gly Gly Gly Gly Gly Gly Gly Thr Ala Met Arg Ile Leu Gly Gly 
    50                  55                  60                  


Val Ile Ser Ala Ile Ser Glu Ala Ala Ala Gln Tyr Asn Pro Glu Pro 
65                  70                  75                  80  


Pro Pro Pro Arg Thr His Tyr Ser Asn Ile Glu Ala Asn Glu Ser Glu 
                85                  90                  95      


Glu Val Arg Gln Phe Arg Arg Leu Phe Ala Gln Leu Ala Gly Asp Asp 
            100                 105                 110         


Met Glu Val Ser Ala Thr Glu Leu Met Asn Ile Leu Asn Lys Val Val 
        115                 120                 125             


Thr Arg His Pro Asp Leu Lys Thr Asp Gly Phe Gly Ile Asp Thr Cys 
    130                 135                 140                 


Arg Ser Met Val Ala Val Met Asp Ser Asp Thr Thr Gly Lys Leu Gly 
145                 150                 155                 160 


Phe Glu Glu Phe Lys Tyr Leu Trp Asn Asn Ile Lys Arg Trp Gln Ala 
                165                 170                 175     


Ile Tyr Lys Gln Phe Asp Thr Asp Arg Ser Gly Thr Ile Cys Ser Ser 
            180                 185                 190         


Glu Leu Pro Gly Ala Phe Glu Ala Ala Gly Phe His Leu Asn Glu His 
        195                 200                 205             


Leu Tyr Asn Met Ile Ile Arg Arg Tyr Ser Asp Glu Ser Gly Asn Met 
    210                 215                 220                 


Asp Phe Asp Asn Phe Ile Ser Cys Leu Val Arg Leu Asp Ala Met Phe 
225                 230                 235                 240 


Arg Ala Phe Lys Ser Leu Asp Lys Asp Gly Thr Gly Gln Ile Gln Val 
                245                 250                 255     


Asn Ile Gln Glu Trp Leu Gln Leu Thr Met Tyr Ser 
            260                 265             


<210>  52
<211>  391
<212>  PRT
<213>  Homo sapiens CK2, alpha subunit

<400>  52

Met Ser Gly Pro Val Pro Ser Arg Ala Arg Val Tyr Thr Asp Val Asn 
1               5                   10                  15      


Thr His Arg Pro Arg Glu Tyr Trp Asp Tyr Glu Ser His Val Val Glu 
            20                  25                  30          


Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg Gly 
        35                  40                  45              


Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Thr Asn Asn Glu Lys 
    50                  55                  60                  


Val Val Val Lys Ile Leu Lys Pro Val Lys Lys Lys Lys Ile Lys Arg 
65                  70                  75                  80  


Glu Ile Lys Ile Leu Glu Asn Leu Arg Gly Gly Pro Asn Ile Ile Thr 
                85                  90                  95      


Leu Ala Asp Ile Val Lys Asp Pro Val Ser Arg Thr Pro Ala Leu Val 
            100                 105                 110         


Phe Glu His Val Asn Asn Thr Asp Phe Lys Gln Leu Tyr Gln Thr Leu 
        115                 120                 125             


Thr Asp Tyr Asp Ile Arg Phe Tyr Met Tyr Glu Ile Leu Lys Ala Leu 
    130                 135                 140                 


Asp Tyr Cys His Ser Met Gly Ile Met His Arg Asp Val Lys Pro His 
145                 150                 155                 160 


Asn Val Met Ile Asp His Glu His Arg Lys Leu Arg Leu Ile Asp Trp 
                165                 170                 175     


Gly Leu Ala Glu Phe Tyr His Pro Gly Gln Glu Tyr Asn Val Arg Val 
            180                 185                 190         


Ala Ser Arg Tyr Phe Lys Gly Pro Glu Leu Leu Val Asp Tyr Gln Met 
        195                 200                 205             


Tyr Asp Tyr Ser Leu Asp Met Trp Ser Leu Gly Cys Met Leu Ala Ser 
    210                 215                 220                 


Met Ile Phe Arg Lys Glu Pro Phe Phe His Gly His Asp Asn Tyr Asp 
225                 230                 235                 240 


Gln Leu Val Arg Ile Ala Lys Val Leu Gly Thr Glu Asp Leu Tyr Asp 
                245                 250                 255     


Tyr Ile Asp Lys Tyr Asn Ile Glu Leu Asp Pro Arg Phe Asn Asp Ile 
            260                 265                 270         


Leu Gly Arg His Ser Arg Lys Arg Trp Glu Arg Phe Val His Ser Glu 
        275                 280                 285             


Asn Gln His Leu Val Ser Pro Glu Ala Leu Asp Phe Leu Asp Lys Leu 
    290                 295                 300                 


Leu Arg Tyr Asp His Gln Ser Arg Leu Thr Ala Arg Glu Ala Met Glu 
305                 310                 315                 320 


His Pro Tyr Phe Tyr Thr Val Val Lys Asp Gln Ala Arg Met Gly Ser 
                325                 330                 335     


Ser Ser Met Pro Gly Gly Ser Thr Pro Val Ser Ser Ala Asn Met Met 
            340                 345                 350         


Ser Gly Ile Ser Ser Val Pro Thr Pro Ser Pro Leu Gly Pro Leu Ala 
        355                 360                 365             


Gly Ser Pro Val Ile Ala Ala Ala Asn Pro Leu Gly Met Pro Val Pro 
    370                 375                 380                 


Ala Ala Ala Gly Ala Gln Gln 
385                 390     


<210>  53
<211>  350
<212>  PRT
<213>  Homo sapiens CK2, alpha prime subunit

<400>  53

Met Pro Gly Pro Ala Ala Gly Ser Arg Ala Arg Val Tyr Ala Glu Val 
1               5                   10                  15      


Asn Ser Leu Arg Ser Arg Glu Tyr Trp Asp Tyr Glu Ala His Val Pro 
            20                  25                  30          


Ser Trp Gly Asn Gln Asp Asp Tyr Gln Leu Val Arg Lys Leu Gly Arg 
        35                  40                  45              


Gly Lys Tyr Ser Glu Val Phe Glu Ala Ile Asn Ile Thr Asn Asn Glu 
    50                  55                  60                  


Arg Val Val Val Lys Ile Leu Lys Pro Val Lys Lys Lys Lys Ile Lys 
65                  70                  75                  80  


Arg Glu Val Lys Ile Leu Glu Asn Leu Arg Gly Gly Thr Asn Ile Ile 
                85                  90                  95      


Lys Leu Ile Asp Thr Val Lys Asp Pro Val Ser Lys Thr Pro Ala Leu 
            100                 105                 110         


Val Phe Glu Tyr Ile Asn Asn Thr Asp Phe Lys Gln Leu Tyr Gln Ile 
        115                 120                 125             


Leu Thr Asp Phe Asp Ile Arg Phe Tyr Met Tyr Glu Leu Leu Lys Ala 
    130                 135                 140                 


Leu Asp Tyr Cys His Ser Lys Gly Ile Met His Arg Asp Val Lys Pro 
145                 150                 155                 160 


His Asn Val Met Ile Asp His Gln Gln Lys Lys Leu Arg Leu Ile Asp 
                165                 170                 175     


Trp Gly Leu Ala Glu Phe Tyr His Pro Ala Gln Glu Tyr Asn Val Arg 
            180                 185                 190         


Val Ala Ser Arg Tyr Phe Lys Gly Pro Glu Leu Leu Val Asp Tyr Gln 
        195                 200                 205             


Met Tyr Asp Tyr Ser Leu Asp Met Trp Ser Leu Gly Cys Met Leu Ala 
    210                 215                 220                 


Ser Met Ile Phe Arg Arg Glu Pro Phe Phe His Gly Gln Asp Asn Tyr 
225                 230                 235                 240 


Asp Gln Leu Val Arg Ile Ala Lys Val Leu Gly Thr Glu Glu Leu Tyr 
                245                 250                 255     


Gly Tyr Leu Lys Lys Tyr His Ile Asp Leu Asp Pro His Phe Asn Asp 
            260                 265                 270         


Ile Leu Gly Gln His Ser Arg Lys Arg Trp Glu Asn Phe Ile His Ser 
        275                 280                 285             


Glu Asn Arg His Leu Val Ser Pro Glu Ala Leu Asp Leu Leu Asp Lys 
    290                 295                 300                 


Leu Leu Arg Tyr Asp His Gln Gln Arg Leu Thr Ala Lys Glu Ala Met 
305                 310                 315                 320 


Glu His Pro Tyr Phe Tyr Pro Val Val Lys Glu Gln Ser Gln Pro Cys 
                325                 330                 335     


Ala Asp Asn Ala Val Leu Ser Ser Gly Leu Thr Ala Ala Arg 
            340                 345                 350 


<210>  54
<211>  215
<212>  PRT
<213>  Homo sapiens CK2, beta subunit

<400>  54

Met Ser Ser Ser Glu Glu Val Ser Trp Ile Ser Trp Phe Cys Gly Leu 
1               5                   10                  15      


Arg Gly Asn Glu Phe Phe Cys Glu Val Asp Glu Asp Tyr Ile Gln Asp 
            20                  25                  30          


Lys Phe Asn Leu Thr Gly Leu Asn Glu Gln Val Pro His Tyr Arg Gln 
        35                  40                  45              


Ala Leu Asp Met Ile Leu Asp Leu Glu Pro Asp Glu Glu Leu Glu Asp 
    50                  55                  60                  


Asn Pro Asn Gln Ser Asp Leu Ile Glu Gln Ala Ala Glu Met Leu Tyr 
65                  70                  75                  80  


Gly Leu Ile His Ala Arg Tyr Ile Leu Thr Asn Arg Gly Ile Ala Gln 
                85                  90                  95      


Met Leu Glu Lys Tyr Gln Gln Gly Asp Phe Gly Tyr Cys Pro Arg Val 
            100                 105                 110         


Tyr Cys Glu Asn Gln Pro Met Leu Pro Ile Gly Leu Ser Asp Ile Pro 
        115                 120                 125             


Gly Glu Ala Met Val Lys Leu Tyr Cys Pro Lys Cys Met Asp Val Tyr 
    130                 135                 140                 


Thr Pro Lys Ser Ser Arg His His His Thr Asp Gly Ala Tyr Phe Gly 
145                 150                 155                 160 


Thr Gly Phe Pro His Met Leu Phe Met Val His Pro Glu Tyr Arg Pro 
                165                 170                 175     


Lys Arg Pro Ala Asn Gln Phe Val Pro Arg Leu Tyr Gly Phe Lys Ile 
            180                 185                 190         


His Pro Met Ala Tyr Gln Leu Gln Leu Gln Ala Ala Ser Asn Phe Lys 
        195                 200                 205             


Ser Pro Val Lys Thr Ile Arg 
    210                 215 


<210>  55
<211>  309
<212>  PRT
<213>  Homo sapiens PP2, catalytic subunit, alpha isozyme

<400>  55

Met Asp Glu Lys Val Phe Thr Lys Glu Leu Asp Gln Trp Ile Glu Gln 
1               5                   10                  15      


Leu Asn Glu Cys Lys Gln Leu Ser Glu Ser Gln Val Lys Ser Leu Cys 
            20                  25                  30          


Glu Lys Ala Lys Glu Ile Leu Thr Lys Glu Ser Asn Val Gln Glu Val 
        35                  40                  45              


Arg Cys Pro Val Thr Val Cys Gly Asp Val His Gly Gln Phe His Asp 
    50                  55                  60                  


Leu Met Glu Leu Phe Arg Ile Gly Gly Lys Ser Pro Asp Thr Asn Tyr 
65                  70                  75                  80  


Leu Phe Met Gly Asp Tyr Val Asp Arg Gly Tyr Tyr Ser Val Glu Thr 
                85                  90                  95      


Val Thr Leu Leu Val Ala Leu Lys Val Arg Tyr Arg Glu Arg Ile Thr 
            100                 105                 110         


Ile Leu Arg Gly Asn His Glu Ser Arg Gln Ile Thr Gln Val Tyr Gly 
        115                 120                 125             


Phe Tyr Asp Glu Cys Leu Arg Lys Tyr Gly Asn Ala Asn Val Trp Lys 
    130                 135                 140                 


Tyr Phe Thr Asp Leu Phe Asp Tyr Leu Pro Leu Thr Ala Leu Val Asp 
145                 150                 155                 160 


Gly Gln Ile Phe Cys Leu His Gly Gly Leu Ser Pro Ser Ile Asp Thr 
                165                 170                 175     


Leu Asp His Ile Arg Ala Leu Asp Arg Leu Gln Glu Val Pro His Glu 
            180                 185                 190         


Gly Pro Met Cys Asp Leu Leu Trp Ser Asp Pro Asp Asp Arg Gly Gly 
        195                 200                 205             


Trp Gly Ile Ser Pro Arg Gly Ala Gly Tyr Thr Phe Gly Gln Asp Ile 
    210                 215                 220                 


Ser Glu Thr Phe Asn His Ala Asn Gly Leu Thr Leu Val Ser Arg Ala 
225                 230                 235                 240 


His Gln Leu Val Met Glu Gly Tyr Asn Trp Cys His Asp Arg Asn Val 
                245                 250                 255     


Val Thr Ile Phe Ser Ala Pro Asn Tyr Cys Tyr Arg Cys Gly Asn Gln 
            260                 265                 270         


Ala Ala Ile Met Glu Leu Asp Asp Thr Leu Lys Tyr Ser Phe Leu Gln 
        275                 280                 285             


Phe Asp Pro Ala Pro Arg Arg Gly Glu Pro His Val Thr Arg Arg Thr 
    290                 295                 300                 


Pro Asp Tyr Phe Leu 
305                 


<210>  56
<211>  447
<212>  PRT
<213>  Homo sapiens protein phosphatase 2, regulatory subunit B, alpha

<400>  56

Met Ala Gly Ala Gly Gly Gly Asn Asp Ile Gln Trp Cys Phe Ser Gln 
1               5                   10                  15      


Val Lys Gly Ala Val Asp Asp Asp Val Ala Glu Ala Asp Ile Ile Ser 
            20                  25                  30          


Thr Val Glu Phe Asn His Ser Gly Glu Leu Leu Ala Thr Gly Asp Lys 
        35                  40                  45              


Gly Gly Arg Val Val Ile Phe Gln Gln Glu Gln Glu Asn Lys Ile Gln 
    50                  55                  60                  


Ser His Ser Arg Gly Glu Tyr Asn Val Tyr Ser Thr Phe Gln Ser His 
65                  70                  75                  80  


Glu Pro Glu Phe Asp Tyr Leu Lys Ser Leu Glu Ile Glu Glu Lys Ile 
                85                  90                  95      


Asn Lys Ile Arg Trp Leu Pro Gln Lys Asn Ala Ala Gln Phe Leu Leu 
            100                 105                 110         


Ser Thr Asn Asp Lys Thr Ile Lys Leu Trp Lys Ile Ser Glu Arg Asp 
        115                 120                 125             


Lys Arg Pro Glu Gly Tyr Asn Leu Lys Glu Glu Asp Gly Arg Tyr Arg 
    130                 135                 140                 


Asp Pro Thr Thr Val Thr Thr Leu Arg Val Pro Val Phe Arg Pro Met 
145                 150                 155                 160 


Asp Leu Met Val Glu Ala Ser Pro Arg Arg Ile Phe Ala Asn Ala His 
                165                 170                 175     


Thr Tyr His Ile Asn Ser Ile Ser Ile Asn Ser Asp Tyr Glu Thr Tyr 
            180                 185                 190         


Leu Ser Ala Asp Asp Leu Arg Ile Asn Leu Trp His Leu Glu Ile Thr 
        195                 200                 205             


Asp Arg Ser Phe Asn Ile Val Asp Ile Lys Pro Ala Asn Met Glu Glu 
    210                 215                 220                 


Leu Thr Glu Val Ile Thr Ala Ala Glu Phe His Pro Asn Ser Cys Asn 
225                 230                 235                 240 


Thr Phe Val Tyr Ser Ser Ser Lys Gly Thr Ile Arg Leu Cys Asp Met 
                245                 250                 255     


Arg Ala Ser Ala Leu Cys Asp Arg His Ser Lys Leu Phe Glu Glu Pro 
            260                 265                 270         


Glu Asp Pro Ser Asn Arg Ser Phe Phe Ser Glu Ile Ile Ser Ser Ile 
        275                 280                 285             


Ser Asp Val Lys Phe Ser His Ser Gly Arg Tyr Met Met Thr Arg Asp 
    290                 295                 300                 


Tyr Leu Ser Val Lys Ile Trp Asp Leu Asn Met Glu Asn Arg Pro Val 
305                 310                 315                 320 


Glu Thr Tyr Gln Val His Glu Tyr Leu Arg Ser Lys Leu Cys Ser Leu 
                325                 330                 335     


Tyr Glu Asn Asp Cys Ile Phe Asp Lys Phe Glu Cys Cys Trp Asn Gly 
            340                 345                 350         


Ser Asp Ser Val Val Met Thr Gly Ser Tyr Asn Asn Phe Phe Arg Met 
        355                 360                 365             


Phe Asp Arg Asn Thr Lys Arg Asp Ile Thr Leu Glu Ala Ser Arg Glu 
    370                 375                 380                 


Asn Asn Lys Pro Arg Thr Val Leu Lys Pro Arg Lys Val Cys Ala Ser 
385                 390                 395                 400 


Gly Lys Arg Lys Lys Asp Glu Ile Ser Val Asp Ser Leu Asp Phe Asn 
                405                 410                 415     


Lys Lys Ile Leu His Thr Ala Trp His Pro Lys Glu Asn Ile Ile Ala 
            420                 425                 430         


Val Ala Thr Thr Asn Asn Leu Tyr Ile Phe Gln Asp Lys Val Asn 
        435                 440                 445         


<210>  57
<211>  589
<212>  PRT
<213>  Homo sapiens protein phosphatase 2, regulatory subunit A, alpha

<400>  57

Met Ala Ala Ala Asp Gly Asp Asp Ser Leu Tyr Pro Ile Ala Val Leu 
1               5                   10                  15      


Ile Asp Glu Leu Arg Asn Glu Asp Val Gln Leu Arg Leu Asn Ser Ile 
            20                  25                  30          


Lys Lys Leu Ser Thr Ile Ala Leu Ala Leu Gly Val Glu Arg Thr Arg 
        35                  40                  45              


Ser Glu Leu Leu Pro Phe Leu Thr Asp Thr Ile Tyr Asp Glu Asp Glu 
    50                  55                  60                  


Val Leu Leu Ala Leu Ala Glu Gln Leu Gly Thr Phe Thr Thr Leu Val 
65                  70                  75                  80  


Gly Gly Pro Glu Tyr Val His Cys Leu Leu Pro Pro Leu Glu Ser Leu 
                85                  90                  95      


Ala Thr Val Glu Glu Thr Val Val Arg Asp Lys Ala Val Glu Ser Leu 
            100                 105                 110         


Arg Ala Ile Ser His Glu His Ser Pro Ser Asp Leu Glu Ala His Phe 
        115                 120                 125             


Val Pro Leu Val Lys Arg Leu Ala Gly Gly Asp Trp Phe Thr Ser Arg 
    130                 135                 140                 


Thr Ser Ala Cys Gly Leu Phe Ser Val Cys Tyr Pro Arg Val Ser Ser 
145                 150                 155                 160 


Ala Val Lys Ala Glu Leu Arg Gln Tyr Phe Arg Asn Leu Cys Ser Asp 
                165                 170                 175     


Asp Thr Pro Met Val Arg Arg Ala Ala Ala Ser Lys Leu Gly Glu Phe 
            180                 185                 190         


Ala Lys Val Leu Glu Leu Asp Asn Val Lys Ser Glu Ile Ile Pro Met 
        195                 200                 205             


Phe Ser Asn Leu Ala Ser Asp Glu Gln Asp Ser Val Arg Leu Leu Ala 
    210                 215                 220                 


Val Glu Ala Cys Val Asn Ile Ala Gln Leu Leu Pro Gln Glu Asp Leu 
225                 230                 235                 240 


Glu Ala Leu Val Met Pro Thr Leu Arg Gln Ala Ala Glu Asp Lys Ser 
                245                 250                 255     


Trp Arg Val Arg Tyr Met Val Ala Asp Lys Phe Thr Glu Leu Gln Lys 
            260                 265                 270         


Ala Val Gly Pro Glu Ile Thr Lys Thr Asp Leu Val Pro Ala Phe Gln 
        275                 280                 285             


Asn Leu Met Lys Asp Cys Glu Ala Glu Val Arg Ala Ala Ala Ser His 
    290                 295                 300                 


Lys Val Lys Glu Phe Cys Glu Asn Leu Ser Ala Asp Cys Arg Glu Asn 
305                 310                 315                 320 


Val Ile Met Ser Gln Ile Leu Pro Cys Ile Lys Glu Leu Val Ser Asp 
                325                 330                 335     


Ala Asn Gln His Val Lys Ser Ala Leu Ala Ser Val Ile Met Gly Leu 
            340                 345                 350         


Ser Pro Ile Leu Gly Lys Asp Asn Thr Ile Glu His Leu Leu Pro Leu 
        355                 360                 365             


Phe Leu Ala Gln Leu Lys Asp Glu Cys Pro Glu Val Arg Leu Asn Ile 
    370                 375                 380                 


Ile Ser Asn Leu Asp Cys Val Asn Glu Val Ile Gly Ile Arg Gln Leu 
385                 390                 395                 400 


Ser Gln Ser Leu Leu Pro Ala Ile Val Glu Leu Ala Glu Asp Ala Lys 
                405                 410                 415     


Trp Arg Val Arg Leu Ala Ile Ile Glu Tyr Met Pro Leu Leu Ala Gly 
            420                 425                 430         


Gln Leu Gly Val Glu Phe Phe Asp Glu Lys Leu Asn Ser Leu Cys Met 
        435                 440                 445             


Ala Trp Leu Val Asp His Val Tyr Ala Ile Arg Glu Ala Ala Thr Ser 
    450                 455                 460                 


Asn Leu Lys Lys Leu Val Glu Lys Phe Gly Lys Glu Trp Ala His Ala 
465                 470                 475                 480 


Thr Ile Ile Pro Lys Val Leu Ala Met Ser Gly Asp Pro Asn Tyr Leu 
                485                 490                 495     


His Arg Met Thr Thr Leu Phe Cys Ile Asn Val Leu Ser Glu Val Cys 
            500                 505                 510         


Gly Gln Asp Ile Thr Thr Lys His Met Leu Pro Thr Val Leu Arg Met 
        515                 520                 525             


Ala Gly Asp Pro Val Ala Asn Val Arg Phe Asn Val Ala Lys Ser Leu 
    530                 535                 540                 


Gln Lys Ile Gly Pro Ile Leu Asp Asn Ser Thr Leu Gln Ser Glu Val 
545                 550                 555                 560 


Lys Pro Ile Leu Glu Lys Leu Thr Gln Asp Gln Asp Val Asp Val Lys 
                565                 570                 575     


Tyr Phe Ala Gln Glu Ala Leu Thr Val Leu Ser Leu Ala 
            580                 585                 


<210>  58
<211>  1987
<212>  PRT
<213>  Homo sapiens protein phosphatase 2, catalytic subunit, beta isozyme

<400>  58

Gly Gly Ala Gly Gly Gly Gly Ala Gly Ala Gly Ala Ala Ala Gly Ala 
1               5                   10                  15      


Gly Cys Gly Ala Gly Ala Gly Ala Ala Gly Gly Gly Gly Ala Ala Ala 
            20                  25                  30          


Gly Ala Cys Ala Ala Gly Thr Cys Gly Gly Gly Ala Gly Ala Gly Gly 
        35                  40                  45              


Cys Cys Gly Gly Thr Ala Gly Gly Cys Gly Thr Gly Ala Gly Gly Cys 
    50                  55                  60                  


Gly Gly Gly Cys Cys Thr Gly Ala Ala Gly Cys Gly Gly Cys Ala Gly 
65                  70                  75                  80  


Cys Gly Gly Gly Cys Gly Gly Cys Cys Thr Thr Cys Gly Thr Cys Cys 
                85                  90                  95      


Gly Gly Cys Gly Ala Gly Ala Gly Cys Thr Ala Gly Gly Cys Cys Gly 
            100                 105                 110         


Ala Gly Gly Ala Cys Cys Cys Gly Cys Gly Cys Cys Gly Cys Gly Cys 
        115                 120                 125             


Thr Cys Cys Cys Cys Gly Gly Cys Ala Cys Cys Thr Cys Ala Cys Cys 
    130                 135                 140                 


Gly Cys Gly Thr Cys Cys Thr Thr Cys Ala Cys Cys Gly Ala Cys Thr 
145                 150                 155                 160 


Cys Cys Cys Gly Cys Gly Gly Cys Gly Cys Gly Cys Gly Gly Cys Cys 
                165                 170                 175     


Gly Gly Gly Cys Gly Gly Gly Gly Ala Ala Gly Gly Gly Cys Gly Gly 
            180                 185                 190         


Gly Cys Gly Gly Gly Gly Gly Thr Cys Thr Cys Cys Thr Cys Cys Ala 
        195                 200                 205             


Gly Gly Cys Thr Gly Cys Gly Cys Gly Cys Thr Cys Gly Gly Ala Gly 
    210                 215                 220                 


Cys Cys Gly Cys Cys Thr Gly Cys Thr Gly Gly Gly Cys Thr Thr Gly 
225                 230                 235                 240 


Gly Gly Cys Gly Gly Gly Gly Cys Gly Cys Gly Gly Gly Gly Cys Cys 
                245                 250                 255     


Cys Gly Cys Gly Gly Cys Cys Gly Cys Cys Cys Thr Ala Cys Cys Cys 
            260                 265                 270         


Gly Gly Cys Thr Cys Ala Gly Thr Cys Cys Thr Cys Cys Cys Cys Cys 
        275                 280                 285             


Thr Gly Thr Gly Gly Gly Ala Cys Cys Thr Gly Gly Cys Gly Ala Cys 
    290                 295                 300                 


Gly Gly Cys Gly Gly Cys Gly Gly Ala Gly Gly Gly Ala Gly Ala Gly 
305                 310                 315                 320 


Gly Gly Gly Ala Gly Cys Gly Gly Cys Gly Cys Cys Cys Gly Gly Gly 
                325                 330                 335     


Cys Cys Gly Gly Gly Gly Cys Cys Gly Gly Gly Gly Gly Cys Gly Gly 
            340                 345                 350         


Gly Thr Gly Gly Gly Gly Ala Gly Gly Gly Gly Gly Gly Ala Gly Gly 
        355                 360                 365             


Gly Cys Gly Gly Cys Gly Gly Cys Cys Gly Gly Gly Cys Thr Gly Gly 
    370                 375                 380                 


Gly Gly Cys Thr Cys Gly Gly Gly Ala Thr Cys Cys Gly Cys Ala Thr 
385                 390                 395                 400 


Cys Gly Gly Gly Ala Thr Cys Gly Gly Gly Cys Cys Gly Cys Cys Ala 
                405                 410                 415     


Thr Gly Gly Ala Cys Gly Ala Cys Ala Ala Gly Gly Cys Gly Thr Thr 
            420                 425                 430         


Cys Ala Cys Cys Ala Ala Gly Gly Ala Gly Cys Thr Gly Gly Ala Cys 
        435                 440                 445             


Cys Ala Gly Thr Gly Gly Gly Thr Cys Gly Ala Gly Cys Ala Gly Cys 
    450                 455                 460                 


Thr Gly Ala Ala Cys Gly Ala Gly Thr Gly Thr Ala Ala Gly Cys Ala 
465                 470                 475                 480 


Gly Cys Thr Gly Ala Ala Cys Gly Ala Gly Ala Ala Cys Cys Ala Ala 
                485                 490                 495     


Gly Thr Gly Cys Gly Gly Ala Cys Gly Cys Thr Gly Thr Gly Cys Gly 
            500                 505                 510         


Ala Gly Ala Ala Gly Gly Cys Ala Ala Ala Gly Gly Ala Ala Ala Thr 
        515                 520                 525             


Thr Thr Thr Ala Ala Cys Ala Ala Ala Ala Gly Ala Ala Thr Cys Ala 
    530                 535                 540                 


Ala Ala Thr Gly Thr Gly Cys Ala Ala Gly Ala Gly Gly Thr Thr Cys 
545                 550                 555                 560 


Gly Thr Thr Gly Cys Cys Cys Thr Gly Thr Thr Ala Cys Thr Gly Thr 
                565                 570                 575     


Cys Thr Gly Thr Gly Gly Ala Gly Ala Thr Gly Thr Gly Cys Ala Thr 
            580                 585                 590         


Gly Gly Thr Cys Ala Ala Thr Thr Thr Cys Ala Thr Gly Ala Thr Cys 
        595                 600                 605             


Thr Thr Ala Thr Gly Gly Ala Ala Cys Thr Cys Thr Thr Thr Ala Gly 
    610                 615                 620                 


Ala Ala Thr Thr Gly Gly Thr Gly Gly Ala Ala Ala Ala Thr Cys Ala 
625                 630                 635                 640 


Cys Cys Gly Gly Ala Thr Ala Cys Ala Ala Ala Cys Thr Ala Cys Thr 
                645                 650                 655     


Thr Ala Thr Thr Cys Ala Thr Gly Gly Gly Thr Gly Ala Cys Thr Ala 
            660                 665                 670         


Thr Gly Thr Ala Gly Ala Cys Ala Gly Ala Gly Gly Ala Thr Ala Thr 
        675                 680                 685             


Thr Ala Thr Thr Cys Ala Gly Thr Gly Gly Ala Gly Ala Cys Thr Gly 
    690                 695                 700                 


Thr Gly Ala Cys Thr Cys Thr Thr Cys Thr Thr Gly Thr Ala Gly Cys 
705                 710                 715                 720 


Ala Thr Thr Ala Ala Ala Gly Gly Thr Gly Cys Gly Thr Thr Ala Thr 
                725                 730                 735     


Cys Cys Ala Gly Ala Ala Cys Gly Cys Ala Thr Thr Ala Cys Ala Ala 
            740                 745                 750         


Thr Ala Thr Thr Gly Ala Gly Ala Gly Gly Ala Ala Ala Thr Cys Ala 
        755                 760                 765             


Cys Gly Ala Ala Ala Gly Cys Cys Gly Ala Cys Ala Ala Ala Thr Thr 
    770                 775                 780                 


Ala Cys Cys Cys Ala Ala Gly Thr Ala Thr Ala Thr Gly Gly Cys Thr 
785                 790                 795                 800 


Thr Thr Thr Ala Thr Gly Ala Thr Gly Ala Ala Thr Gly Thr Cys Thr 
                805                 810                 815     


Gly Cys Gly Ala Ala Ala Gly Thr Ala Thr Gly Gly Gly Ala Ala Thr 
            820                 825                 830         


Gly Cys Cys Ala Ala Cys Gly Thr Thr Thr Gly Gly Ala Ala Ala Thr 
        835                 840                 845             


Ala Thr Thr Thr Thr Ala Cys Ala Gly Ala Thr Cys Thr Cys Thr Thr 
    850                 855                 860                 


Thr Gly Ala Thr Thr Ala Thr Cys Thr Thr Cys Cys Ala Cys Thr Thr 
865                 870                 875                 880 


Ala Cys Ala Gly Cys Thr Thr Thr Ala Gly Thr Ala Gly Ala Thr Gly 
                885                 890                 895     


Gly Ala Cys Ala Gly Ala Thr Ala Thr Thr Cys Thr Gly Cys Cys Thr 
            900                 905                 910         


Cys Cys Ala Thr Gly Gly Thr Gly Gly Cys Cys Thr Cys Thr Cys Thr 
        915                 920                 925             


Cys Cys Ala Thr Cys Cys Ala Thr Ala Gly Ala Cys Ala Cys Ala Cys 
    930                 935                 940                 


Thr Gly Gly Ala Thr Cys Ala Thr Ala Thr Ala Ala Gly Ala Gly Cys 
945                 950                 955                 960 


Cys Cys Thr Gly Gly Ala Thr Cys Gly Thr Thr Thr Ala Cys Ala Gly 
                965                 970                 975     


Gly Ala Ala Gly Thr Thr Cys Cys Ala Cys Ala Thr Gly Ala Gly Gly 
            980                 985                 990         


Gly Cys Cys Cys Ala Ala Thr Gly  Thr Gly Thr Gly Ala  Thr Cys Thr 
        995                 1000                 1005             


Gly Thr  Thr Ala Thr Gly Gly  Thr Cys Ala Gly Ala  Thr Cys Cys 
    1010                 1015                 1020             


Ala Gly  Ala Thr Gly Ala Thr  Cys Gly Thr Gly Gly  Thr Gly Gly 
    1025                 1030                 1035             


Ala Thr  Gly Gly Gly Gly Thr  Ala Thr Thr Thr Cys  Ala Cys Cys 
    1040                 1045                 1050             


Ala Cys  Gly Thr Gly Gly Thr  Gly Cys Thr Gly Gly  Cys Thr Ala 
    1055                 1060                 1065             


Cys Ala  Cys Ala Thr Thr Thr  Gly Gly Ala Cys Ala  Ala Gly Ala 
    1070                 1075                 1080             


Cys Ala  Thr Thr Thr Cys Thr  Gly Ala Ala Ala Cys  Cys Thr Thr 
    1085                 1090                 1095             


Thr Ala  Ala Cys Cys Ala Thr  Gly Cys Cys Ala Ala  Thr Gly Gly 
    1100                 1105                 1110             


Thr Cys  Thr Cys Ala Cys Ala  Cys Thr Gly Gly Thr  Thr Thr Cys 
    1115                 1120                 1125             


Thr Cys  Gly Thr Gly Cys Cys  Cys Ala Cys Cys Ala  Gly Cys Thr 
    1130                 1135                 1140             


Thr Gly  Thr Ala Ala Thr Gly  Gly Ala Gly Gly Gly  Ala Thr Ala 
    1145                 1150                 1155             


Cys Ala  Ala Thr Thr Gly Gly  Thr Gly Thr Cys Ala  Thr Gly Ala 
    1160                 1165                 1170             


Thr Cys  Gly Gly Ala Ala Thr  Gly Thr Gly Gly Thr  Thr Ala Cys 
    1175                 1180                 1185             


Cys Ala  Thr Thr Thr Thr Cys  Ala Gly Thr Gly Cys  Ala Cys Cys 
    1190                 1195                 1200             


Cys Ala  Ala Thr Thr Ala Cys  Thr Gly Thr Thr Ala  Thr Cys Gly 
    1205                 1210                 1215             


Thr Thr  Gly Thr Gly Gly Gly  Ala Ala Cys Cys Ala  Gly Gly Cys 
    1220                 1225                 1230             


Thr Gly  Cys Thr Ala Thr Cys  Ala Thr Gly Gly Ala  Ala Thr Thr 
    1235                 1240                 1245             


Ala Gly  Ala Thr Gly Ala Cys  Ala Cys Thr Thr Thr  Ala Ala Ala 
    1250                 1255                 1260             


Ala Thr  Ala Thr Thr Cys Cys  Thr Thr Cys Cys Thr  Thr Cys Ala 
    1265                 1270                 1275             


Ala Thr  Thr Thr Gly Ala Cys  Cys Cys Ala Gly Cys  Gly Cys Cys 
    1280                 1285                 1290             


Thr Cys  Gly Thr Cys Gly Thr  Gly Gly Thr Gly Ala  Gly Cys Cys 
    1295                 1300                 1305             


Thr Cys  Ala Thr Gly Thr Thr  Ala Cys Ala Cys Gly  Gly Cys Gly 
    1310                 1315                 1320             


Cys Ala  Cys Cys Cys Cys Ala  Gly Ala Cys Thr Ala  Cys Thr Thr 
    1325                 1330                 1335             


Cys Cys  Thr Ala Thr Ala Ala  Ala Thr Thr Thr Cys  Thr Cys Cys 
    1340                 1345                 1350             


Thr Gly  Gly Gly Ala Ala Ala  Cys Cys Thr Gly Cys  Cys Thr Thr 
    1355                 1360                 1365             


Thr Gly  Thr Ala Thr Gly Thr  Gly Gly Ala Ala Gly  Thr Ala Thr 
    1370                 1375                 1380             


Ala Cys  Cys Thr Gly Gly Cys  Thr Thr Thr Thr Thr  Ala Ala Ala 
    1385                 1390                 1395             


Ala Thr  Ala Thr Ala Thr Gly  Thr Ala Thr Thr Thr  Ala Ala Ala 
    1400                 1405                 1410             


Ala Ala  Cys Ala Ala Ala Ala  Ala Gly Cys Ala Ala  Cys Ala Gly 
    1415                 1420                 1425             


Thr Ala  Ala Thr Cys Thr Ala  Thr Gly Thr Gly Thr  Thr Thr Cys 
    1430                 1435                 1440             


Thr Gly  Thr Ala Ala Cys Ala  Ala Ala Thr Thr Gly  Gly Gly Ala 
    1445                 1450                 1455             


Thr Cys  Thr Gly Thr Cys Thr  Thr Gly Gly Cys Ala  Thr Thr Ala 
    1460                 1465                 1470             


Ala Ala  Cys Cys Ala Cys Ala  Thr Cys Ala Thr Gly  Gly Ala Cys 
    1475                 1480                 1485             


Cys Ala  Ala Ala Thr Gly Thr  Gly Cys Cys Ala Thr  Ala Cys Thr 
    1490                 1495                 1500             


Ala Ala  Thr Gly Ala Thr Gly  Ala Gly Cys Ala Thr  Thr Thr Ala 
    1505                 1510                 1515             


Gly Cys  Ala Cys Ala Ala Thr  Thr Thr Gly Ala Gly  Ala Cys Thr 
    1520                 1525                 1530             


Gly Ala  Ala Ala Thr Thr Thr  Ala Gly Thr Ala Cys  Ala Cys Thr 
    1535                 1540                 1545             


Ala Thr  Gly Thr Thr Cys Thr  Ala Gly Gly Thr Cys  Ala Gly Thr 
    1550                 1555                 1560             


Cys Thr  Ala Ala Cys Ala Gly  Thr Thr Thr Gly Cys  Cys Thr Gly 
    1565                 1570                 1575             


Cys Thr  Gly Thr Ala Thr Thr  Thr Ala Thr Ala Gly  Thr Ala Ala 
    1580                 1585                 1590             


Cys Cys  Ala Thr Thr Thr Thr  Cys Cys Thr Thr Thr  Gly Gly Ala 
    1595                 1600                 1605             


Cys Thr  Gly Thr Thr Cys Ala  Ala Gly Cys Ala Ala  Ala Ala Ala 
    1610                 1615                 1620             


Ala Gly  Gly Thr Ala Ala Cys  Thr Ala Ala Cys Thr  Gly Cys Thr 
    1625                 1630                 1635             


Thr Cys  Ala Thr Cys Thr Cys  Cys Thr Thr Thr Thr  Gly Cys Gly 
    1640                 1645                 1650             


Cys Thr  Thr Ala Thr Thr Thr  Gly Gly Ala Ala Ala  Thr Thr Thr 
    1655                 1660                 1665             


Thr Ala  Gly Thr Thr Ala Thr  Ala Gly Thr Gly Thr  Thr Thr Ala 
    1670                 1675                 1680             


Ala Cys  Thr Gly Gly Cys Ala  Thr Gly Gly Ala Thr  Thr Ala Ala 
    1685                 1690                 1695             


Thr Ala  Gly Ala Gly Thr Thr  Gly Gly Ala Gly Thr  Thr Thr Thr 
    1700                 1705                 1710             


Ala Thr  Thr Thr Thr Thr Ala  Ala Gly Ala Ala Ala  Ala Ala Thr 
    1715                 1720                 1725             


Thr Cys  Ala Cys Ala Ala Gly  Cys Thr Ala Ala Cys  Thr Thr Cys 
    1730                 1735                 1740             


Cys Ala  Cys Thr Ala Ala Thr  Cys Cys Ala Thr Thr  Ala Thr Cys 
    1745                 1750                 1755             


Cys Thr  Thr Thr Ala Thr Thr  Thr Thr Ala Thr Thr  Gly Ala Ala 
    1760                 1765                 1770             


Ala Thr  Gly Thr Ala Thr Ala  Ala Thr Thr Ala Ala  Cys Thr Thr 
    1775                 1780                 1785             


Ala Ala  Cys Thr Gly Ala Ala  Gly Ala Ala Ala Ala  Gly Gly Thr 
    1790                 1795                 1800             


Thr Cys  Thr Thr Cys Thr Thr  Gly Gly Gly Ala Gly  Thr Ala Thr 
    1805                 1810                 1815             


Gly Thr  Thr Gly Thr Cys Ala  Thr Ala Ala Cys Ala  Thr Thr Thr 
    1820                 1825                 1830             


Ala Ala  Ala Gly Ala Gly Ala  Thr Thr Thr Cys Cys  Cys Thr Thr 
    1835                 1840                 1845             


Cys Ala  Thr Thr Thr Ala Ala  Ala Cys Thr Ala Ala  Ala Thr Thr 
    1850                 1855                 1860             


Ala Cys  Thr Gly Thr Thr Thr  Thr Ala Thr Gly Thr  Thr Gly Ala 
    1865                 1870                 1875             


Thr Cys  Thr Gly Cys Ala Thr  Ala Thr Thr Thr Cys  Thr Gly Thr 
    1880                 1885                 1890             


Ala Thr  Ala Thr Thr Thr Gly  Thr Cys Ala Thr Gly  Ala Cys Ala 
    1895                 1900                 1905             


Gly Thr  Gly Cys Thr Thr Gly  Cys Ala Thr Cys Cys  Thr Ala Thr 
    1910                 1915                 1920             


Thr Thr  Gly Gly Thr Gly Thr  Ala Cys Thr Cys Ala  Gly Cys Ala 
    1925                 1930                 1935             


Ala Ala  Thr Ala Ala Ala Cys  Thr Thr Thr Thr Cys  Ala Thr Thr 
    1940                 1945                 1950             


Thr Thr  Ala Ala Ala Cys Ala  Ala Ala Ala Ala Cys  Ala Thr Thr 
    1955                 1960                 1965             


Cys Ala  Ala Ala Ala Ala Ala  Ala Ala Ala Ala Ala  Ala Ala Ala 
    1970                 1975                 1980             


Ala Ala  Ala Ala 
    1985         


<210>  59
<211>  309
<212>  PRT
<213>  Homo sapiens protein phosphatase 2, catalytic subunit, beta isozyme

<400>  59

Met Asp Asp Lys Ala Phe Thr Lys Glu Leu Asp Gln Trp Val Glu Gln 
1               5                   10                  15      


Leu Asn Glu Cys Lys Gln Leu Asn Glu Asn Gln Val Arg Thr Leu Cys 
            20                  25                  30          


Glu Lys Ala Lys Glu Ile Leu Thr Lys Glu Ser Asn Val Gln Glu Val 
        35                  40                  45              


Arg Cys Pro Val Thr Val Cys Gly Asp Val His Gly Gln Phe His Asp 
    50                  55                  60                  


Leu Met Glu Leu Phe Arg Ile Gly Gly Lys Ser Pro Asp Thr Asn Tyr 
65                  70                  75                  80  


Leu Phe Met Gly Asp Tyr Val Asp Arg Gly Tyr Tyr Ser Val Glu Thr 
                85                  90                  95      


Val Thr Leu Leu Val Ala Leu Lys Val Arg Tyr Pro Glu Arg Ile Thr 
            100                 105                 110         


Ile Leu Arg Gly Asn His Glu Ser Arg Gln Ile Thr Gln Val Tyr Gly 
        115                 120                 125             


Phe Tyr Asp Glu Cys Leu Arg Lys Tyr Gly Asn Ala Asn Val Trp Lys 
    130                 135                 140                 


Tyr Phe Thr Asp Leu Phe Asp Tyr Leu Pro Leu Thr Ala Leu Val Asp 
145                 150                 155                 160 


Gly Gln Ile Phe Cys Leu His Gly Gly Leu Ser Pro Ser Ile Asp Thr 
                165                 170                 175     


Leu Asp His Ile Arg Ala Leu Asp Arg Leu Gln Glu Val Pro His Glu 
            180                 185                 190         


Gly Pro Met Cys Asp Leu Leu Trp Ser Asp Pro Asp Asp Arg Gly Gly 
        195                 200                 205             


Trp Gly Ile Ser Pro Arg Gly Ala Gly Tyr Thr Phe Gly Gln Asp Ile 
    210                 215                 220                 


Ser Glu Thr Phe Asn His Ala Asn Gly Leu Thr Leu Val Ser Arg Ala 
225                 230                 235                 240 


His Gln Leu Val Met Glu Gly Tyr Asn Trp Cys His Asp Arg Asn Val 
                245                 250                 255     


Val Thr Ile Phe Ser Ala Pro Asn Tyr Cys Tyr Arg Cys Gly Asn Gln 
            260                 265                 270         


Ala Ala Ile Met Glu Leu Asp Asp Thr Leu Lys Tyr Ser Phe Leu Gln 
        275                 280                 285             


Phe Asp Pro Ala Pro Arg Arg Gly Glu Pro His Val Thr Arg Arg Thr 
    290                 295                 300                 


Pro Asp Tyr Phe Leu 
305                 


