                         SEQUENCE LISTING

<110>  Medical Research Council
       Royal Holloway and Bedford New College
 
<120>  Complexing System

<130>  P524557PCT

<150>  GB 0914121.9
<151>  2009-08-12

<150>  US 61/319,204
<151>  2010-03-30

<160>  77    

<170>  PatentIn version 3.5

<210>  1
<211>  45
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  1

Ser Thr Arg Arg Met Leu Gln Leu Val Glu Glu Ser Lys Asp Ala Gly 
1               5                   10                  15      


Ile Arg Thr Leu Val Met Leu Asp Glu Gln Gly Glu Gln Leu Asp Arg 
            20                  25                  30          


Val Glu Glu Gly Met Asn His Ile Gly Ser Gly Gly Gly 
        35                  40                  45  


<210>  2
<211>  51
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  2

Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu Arg His Met Ala 
1               5                   10                  15      


Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg Gln Ile Asp Arg 
            20                  25                  30          


Ile Met Glu Lys Ala Asp Ser Asn Gly Ser Gly Gly Gly His His His 
        35                  40                  45              


His His His 
    50      


<210>  3
<211>  52
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  3

Glu Ile Ile Lys Leu Glu Asn Ser Ile Arg Glu Leu His Asp Met Phe 
1               5                   10                  15      


Met Asp Met Ala Met Leu Val Glu Ser Gln Gly Glu Met Ile Asp Arg 
            20                  25                  30          


Ile Glu Tyr Asn Val Glu His Ala Gly Ser Gly Gly Gly His His His 
        35                  40                  45              


His His His Cys 
    50          


<210>  4
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  4

Arg Leu Gln Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met 
1               5                   10                  15      


Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu 
            20                  25                  30          


Leu Asp Asp Arg Ala Asp Ala Leu Gly Ser Lys Glu Thr Ala Ala Ala 
        35                  40                  45              


Lys Phe Glu Arg Gln His Met Asp Ser 
    50                  55          


<210>  5
<211>  46
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  5

Ser Thr Arg Arg Met Leu Gln Leu Val Glu Glu Ser Lys Asp Ala Gly 
1               5                   10                  15      


Ile Arg Thr Leu Val Met Leu Asp Glu Gln Gly Glu Gln Leu Asp Arg 
            20                  25                  30          


Val Glu Glu Gly Met Asn His Ile Asn Gln Asp Met Lys Cys 
        35                  40                  45      


<210>  6
<211>  59
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  6

Cys Asn Glu Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile Ile Gly 
1               5                   10                  15      


Asn Leu Arg His Met Ala Leu Asp Met Gly Asn Glu Ile Asp Thr Gln 
            20                  25                  30          


Asn Arg Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr 
        35                  40                  45              


Arg Ile Asp Gly Gly His His His His His His 
    50                  55                  


<210>  7
<211>  50
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  7

Ala Glu Asp Ala Glu Ile Ile Lys Leu Glu Asn Ser Ile Arg Glu Leu 
1               5                   10                  15      


His Asp Met Phe Met Asp Met Ala Met Leu Val Glu Ser Gln Gly Glu 
            20                  25                  30          


Met Ile Asp Arg Ile Glu Tyr Asn Val Glu His Ala Val Asp Tyr Val 
        35                  40                  45              


Glu Cys 
    50  


<210>  8
<211>  75
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  8

Met Ser Ala Thr Ala Ala Thr Val Pro Pro Ala Ala Pro Ala Gly Glu 
1               5                   10                  15      


Gly Gly Pro Pro Ala Pro Pro Pro Asn Leu Thr Ser Asn Arg Arg Leu 
            20                  25                  30          


Gln Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met Arg Val 
        35                  40                  45              


Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp 
    50                  55                  60                  


Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser 
65                  70                  75  


<210>  9
<211>  54
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  9

Glu Ile Ile Lys Leu Glu Asn Ser Ile Arg Glu Leu His Asp Met Phe 
1               5                   10                  15      


Met Asp Met Ala Met Leu Val Glu Ser Gln Gly Glu Met Ile Asp Arg 
            20                  25                  30          


Ile Glu Tyr Asn Val Glu His Ala Gly Ser Gly Glu Gln Lys Leu Ile 
        35                  40                  45              


Ser Glu Glu Asp Leu Cys 
    50                  


<210>  10
<211>  13
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  10

Gly Ile Leu Asp Ser Met Gly Arg Leu Glu Leu Lys Leu 
1               5                   10              


<210>  11
<211>  15
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  11

Gly Ser Gly Ser Glu Gln Lys Leu Ile Ser Glu Glu Asp Leu Gly 
1               5                   10                  15  


<210>  12
<211>  359
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  12

Gly Ser Met Lys Asp Arg Leu Glu Gln Leu Lys Ala Lys Gln Leu Thr 
1               5                   10                  15      


Gln Asp Asp Asp Thr Asp Glu Val Glu Ile Ala Ile Asp Asn Thr Ala 
            20                  25                  30          


Phe Met Asp Glu Phe Phe Ser Glu Ile Glu Glu Thr Arg Leu Asn Ile 
        35                  40                  45              


Asp Lys Ile Ser Glu His Val Glu Glu Ala Lys Lys Leu Tyr Ser Ile 
    50                  55                  60                  


Ile Leu Ser Ala Pro Ile Pro Glu Pro Lys Thr Lys Asp Asp Leu Glu 
65                  70                  75                  80  


Gln Leu Thr Thr Glu Ile Lys Lys Arg Ala Asn Asn Val Arg Asn Lys 
                85                  90                  95      


Leu Lys Ser Met Glu Lys His Ile Glu Glu Asp Glu Val Arg Ser Ser 
            100                 105                 110         


Ala Asp Leu Arg Ile Arg Lys Ser Gln His Ser Val Leu Ser Arg Lys 
        115                 120                 125             


Phe Val Glu Val Met Thr Lys Tyr Asn Glu Ala Gln Val Asp Phe Arg 
    130                 135                 140                 


Glu Arg Ser Lys Gly Arg Ile Gln Arg Gln Leu Glu Ile Thr Gly Lys 
145                 150                 155                 160 


Lys Thr Thr Asp Glu Glu Leu Glu Glu Met Leu Glu Ser Gly Asn Pro 
                165                 170                 175     


Ala Ile Phe Thr Ser Gly Ile Ile Asp Ser Gln Ile Ser Lys Gln Ala 
            180                 185                 190         


Leu Ser Glu Ile Glu Gly Arg His Lys Asp Ile Val Arg Leu Glu Ser 
        195                 200                 205             


Ser Ile Lys Glu Leu His Asp Met Phe Met Asp Ile Ala Met Leu Val 
    210                 215                 220                 


Glu Asn Gln Gly Glu Met Leu Asp Asn Ile Glu Leu Asn Val Met His 
225                 230                 235                 240 


Thr Val Asp His Val Glu Lys Ala Arg Asp Glu Thr Lys Arg Ala Met 
                245                 250                 255     


Lys Tyr Gln Gly Gln Ala Gly Ile Leu Asp Ser Met Gly Arg Leu Glu 
            260                 265                 270         


Leu Lys Leu Met Ser Ala Thr Ala Ala Thr Val Pro Pro Ala Ala Pro 
        275                 280                 285             


Ala Gly Glu Gly Gly Pro Pro Ala Pro Pro Pro Asn Leu Thr Ser Asn 
    290                 295                 300                 


Arg Arg Leu Gln Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile 
305                 310                 315                 320 


Met Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser 
                325                 330                 335     


Glu Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe 
            340                 345                 350         


Glu Thr Ser Ala Ala Lys Leu 
        355                 


<210>  13
<211>  158
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  13

Gly Ser Glu Gly Arg His Lys Asp Ile Val Arg Leu Glu Ser Ser Ile 
1               5                   10                  15      


Lys Glu Leu His Asp Met Phe Met Asp Ile Ala Met Leu Val Glu Asn 
            20                  25                  30          


Gln Gly Glu Met Leu Asp Asn Ile Glu Leu Asn Val Met His Thr Val 
        35                  40                  45              


Asp His Val Glu Lys Ala Arg Asp Glu Ala Lys Arg Ala Gly Ile Leu 
    50                  55                  60                  


Asp Ser Met Gly Arg Leu Glu Leu Lys Leu Met Ser Ala Thr Ala Ala 
65                  70                  75                  80  


Thr Val Pro Pro Ala Ala Pro Ala Gly Glu Gly Gly Pro Pro Ala Pro 
                85                  90                  95      


Pro Pro Asn Leu Thr Ser Asn Arg Arg Leu Gln Gln Thr Gln Ala Gln 
            100                 105                 110         


Val Asp Glu Val Val Asp Ile Met Arg Val Asn Val Asp Lys Val Leu 
        115                 120                 125             


Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp Arg Ala Asp Ala Leu 
    130                 135                 140                 


Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala Ala Lys Leu 
145                 150                 155             


<210>  14
<211>  312
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  14

Gly Ser Met Lys Asp Arg Leu Glu Gln Leu Lys Ala Lys Gln Leu Thr 
1               5                   10                  15      


Gln Asp Asp Asp Thr Asp Glu Val Glu Ile Ala Ile Asp Asn Thr Ala 
            20                  25                  30          


Phe Met Asp Glu Phe Phe Ser Glu Ile Glu Glu Thr Arg Leu Asn Ile 
        35                  40                  45              


Asp Lys Ile Ser Glu His Val Glu Glu Ala Lys Lys Leu Tyr Ser Ile 
    50                  55                  60                  


Ile Leu Ser Ala Pro Ile Pro Glu Pro Lys Thr Lys Asp Asp Leu Glu 
65                  70                  75                  80  


Gln Leu Thr Thr Glu Ile Lys Lys Arg Ala Asn Asn Val Arg Asn Lys 
                85                  90                  95      


Leu Lys Ser Met Glu Lys His Ile Glu Glu Asp Glu Val Arg Ser Ser 
            100                 105                 110         


Ala Asp Leu Arg Ile Arg Lys Ser Gln His Ser Val Leu Ser Arg Lys 
        115                 120                 125             


Phe Val Glu Val Met Thr Lys Tyr Asn Glu Ala Gln Val Asp Phe Arg 
    130                 135                 140                 


Glu Arg Ser Lys Gly Arg Ile Gln Arg Gln Leu Glu Ile Thr Gly Lys 
145                 150                 155                 160 


Lys Thr Thr Asp Glu Glu Leu Glu Glu Met Leu Glu Ser Gly Asn Pro 
                165                 170                 175     


Ala Ile Phe Thr Ser Gly Ile Ile Asp Ser Gln Ile Ser Lys Gln Ala 
            180                 185                 190         


Leu Ser Glu Ile Glu Gly Arg His Lys Asp Ile Val Arg Leu Glu Ser 
        195                 200                 205             


Ser Ile Lys Glu Leu His Asp Met Phe Met Asp Ile Ala Met Leu Val 
    210                 215                 220                 


Glu Asn Gln Gly Glu Met Leu Asp Asn Ile Glu Leu Asn Val Met His 
225                 230                 235                 240 


Thr Val Asp His Val Glu Lys Ala Arg Asp Glu Ala Lys Arg Ala Gly 
                245                 250                 255     


Asn Arg Arg Leu Gln Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp 
            260                 265                 270         


Ile Met Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu 
        275                 280                 285             


Ser Glu Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln 
    290                 295                 300                 


Phe Glu Thr Ser Ala Ala Lys Leu 
305                 310         


<210>  15
<211>  283
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  15

Gly Ser Ala Asp Glu Ser Leu Glu Ser Thr Arg Arg Met Leu Gln Leu 
1               5                   10                  15      


Val Glu Glu Ser Lys Asp Ala Gly Ile Arg Thr Leu Val Met Leu Asp 
            20                  25                  30          


Glu Gln Gly Glu Gln Leu Glu Arg Ile Glu Glu Gly Met Asp Gln Ile 
        35                  40                  45              


Asn Lys Asp Met Lys Glu Ala Glu Lys Asn Leu Thr Asp Leu Gly Lys 
    50                  55                  60                  


Phe Ala Gly Leu Ala Val Ala Pro Ala Asn Lys Leu Lys Ser Ser Asp 
65                  70                  75                  80  


Ala Tyr Lys Lys Ala Trp Gly Asn Asn Gln Asp Gly Val Val Ala Ser 
                85                  90                  95      


Gln Pro Ala Arg Val Val Asp Glu Arg Glu Gln Met Ala Ile Ser Gly 
            100                 105                 110         


Gly Phe Ile Arg Arg Val Thr Asn Asp Ala Arg Glu Asn Glu Met Asp 
        115                 120                 125             


Glu Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu Arg His Met 
    130                 135                 140                 


Ala Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg Gln Ile Asp 
145                 150                 155                 160 


Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile Asp Glu Ala 
                165                 170                 175     


Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly Ser Glu Gln Lys Leu 
            180                 185                 190         


Ile Ser Glu Glu Asp Leu Gly Met Ser Ala Thr Ala Ala Thr Val Pro 
        195                 200                 205             


Pro Ala Ala Pro Ala Gly Glu Gly Gly Pro Pro Ala Pro Pro Pro Asn 
    210                 215                 220                 


Leu Thr Ser Asn Arg Arg Leu Gln Gln Thr Gln Ala Gln Val Asp Glu 
225                 230                 235                 240 


Val Val Asp Ile Met Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp 
                245                 250                 255     


Gln Lys Leu Ser Glu Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly 
            260                 265                 270         


Ala Ser Gln Phe Glu Thr Ser Ala Ala Lys Leu 
        275                 280             


<210>  16
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  16

Leu Val Pro Arg Gly Ser 
1               5       


<210>  17
<211>  6
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  17

Leu Val Pro Arg Gly Ser 
1               5       


<210>  18
<211>  1095
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  18

Gly Ser Pro Gly Met Pro Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp 
1               5                   10                  15      


Pro Val Asn Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly 
            20                  25                  30          


Gln Met Gln Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val 
        35                  40                  45              


Ile Pro Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn 
    50                  55                  60                  


Pro Pro Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr 
65                  70                  75                  80  


Tyr Leu Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr 
                85                  90                  95      


Lys Leu Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu 
            100                 105                 110         


Thr Ser Ile Val Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp 
        115                 120                 125             


Thr Glu Leu Lys Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro 
    130                 135                 140                 


Asp Gly Ser Tyr Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro 
145                 150                 155                 160 


Ser Ala Asp Ile Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val 
                165                 170                 175     


Leu Asn Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe 
            180                 185                 190         


Ser Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr 
        195                 200                 205             


Asn Pro Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr 
    210                 215                 220                 


Leu Ala His Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala 
225                 230                 235                 240 


Ile Asn Pro Asn Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu 
                245                 250                 255     


Met Ser Gly Leu Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly 
            260                 265                 270         


His Asp Ala Lys Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu 
        275                 280                 285             


Tyr Tyr Tyr Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala 
    290                 295                 300                 


Lys Ser Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val 
305                 310                 315                 320 


Phe Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser 
                325                 330                 335     


Val Asp Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile 
            340                 345                 350         


Tyr Thr Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu Asn Arg Lys 
        355                 360                 365             


Thr Tyr Leu Asn Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro 
    370                 375                 380                 


Lys Val Asn Tyr Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn 
385                 390                 395                 400 


Leu Ala Ala Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn 
                405                 410                 415     


Phe Thr Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu 
            420                 425                 430         


Leu Cys Val Arg Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Asp Lys 
        435                 440                 445             


Gly Tyr Asn Lys Ala Lys Ser Leu Val Pro Arg Gly Ser Gln Ala Leu 
    450                 455                 460                 


Asn Asp Leu Cys Ile Lys Val Asn Asn Trp Asp Leu Phe Phe Ser Pro 
465                 470                 475                 480 


Ser Glu Asp Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu Ile Thr 
                485                 490                 495     


Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu Asp Leu 
            500                 505                 510         


Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu Asn 
        515                 520                 525             


Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu Glu Leu 
    530                 535                 540                 


Met Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu Leu Asp 
545                 550                 555                 560 


Lys Tyr Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu His Gly 
                565                 570                 575     


Lys Ser Arg Ile Ala Leu Thr Asn Ser Val Asn Glu Ala Leu Leu Asn 
            580                 585                 590         


Pro Ser Arg Val Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys Lys Val 
        595                 600                 605             


Asn Lys Ala Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu Gln Leu 
    610                 615                 620                 


Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys 
625                 630                 635                 640 


Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn 
                645                 650                 655     


Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu Ile Phe 
            660                 665                 670         


Ser Gly Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala Ile Pro 
        675                 680                 685             


Val Leu Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys Val Leu 
    690                 695                 700                 


Thr Val Gln Thr Ile Asp Asn Ala Leu Ser Lys Arg Asn Glu Lys Trp 
705                 710                 715                 720 


Asp Glu Val Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys Val Asn 
                725                 730                 735     


Thr Gln Ile Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu Glu Asn 
            740                 745                 750         


Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr 
        755                 760                 765             


Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp Leu Ser 
    770                 775                 780                 


Ser Lys Leu Asn Glu Ser Ile Asn Lys Ala Met Ile Asn Ile Asn Lys 
785                 790                 795                 800 


Phe Leu Asn Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met Ile Pro 
                805                 810                 815     


Tyr Gly Val Lys Arg Leu Glu Asp Phe Asp Ala Ser Leu Lys Asp Ala 
            820                 825                 830         


Leu Leu Lys Tyr Ile Tyr Asp Asn Arg Gly Thr Leu Ile Gly Gln Val 
        835                 840                 845             


Asp Arg Leu Lys Asp Lys Val Asn Asn Thr Leu Ser Thr Asp Ile Pro 
    850                 855                 860                 


Phe Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser Thr Phe 
865                 870                 875                 880 


Thr Glu Tyr Ile Lys Asn Ile Arg Ser Met Ala Glu Asp Ala Asp Met 
                885                 890                 895     


Arg Asn Glu Leu Glu Glu Met Gln Arg Arg Ala Asp Gln Leu Ala Asp 
            900                 905                 910         


Glu Ser Leu Glu Ser Thr Arg Arg Met Leu Gln Leu Val Glu Glu Ser 
        915                 920                 925             


Lys Asp Ala Gly Ile Arg Thr Leu Val Met Leu Asp Glu Gln Gly Glu 
    930                 935                 940                 


Gln Leu Glu Arg Ile Glu Glu Gly Met Asp Gln Ile Asn Lys Asp Met 
945                 950                 955                 960 


Lys Glu Ala Glu Lys Asn Leu Thr Asp Leu Gly Lys Phe Ala Gly Leu 
                965                 970                 975     


Ala Val Ala Pro Ala Asn Lys Leu Lys Ser Ser Asp Ala Tyr Lys Lys 
            980                 985                 990         


Ala Trp Gly Asn Asn Gln Asp Gly  Val Val Ala Ser Gln  Pro Ala Arg 
        995                 1000                 1005             


Val Val  Asp Glu Arg Glu Gln  Met Ala Ile Ser Gly  Gly Phe Ile 
    1010                 1015                 1020             


Arg Arg  Val Thr Asn Asp Ala  Arg Glu Asn Glu Met  Asp Glu Asn 
    1025                 1030                 1035             


Leu Glu  Gln Val Ser Gly Ile  Ile Gly Asn Leu Arg  His Met Ala 
    1040                 1045                 1050             


Leu Asp  Met Gly Asn Glu Ile  Asp Thr Gln Asn Arg  Gln Ile Asp 
    1055                 1060                 1065             


Arg Ile  Met Glu Lys Ala Asp  Ser Asn Lys Thr Arg  Ile Asp Glu 
    1070                 1075                 1080             


Ala Asn  Gln Arg Ala Thr Lys  Met Leu Gly Ser Gly  
    1085                 1090                 1095 


<210>  19
<211>  949
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  19

Gly Ser Pro Gly Met Pro Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp 
1               5                   10                  15      


Pro Val Asn Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly 
            20                  25                  30          


Gln Met Gln Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val 
        35                  40                  45              


Ile Pro Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn 
    50                  55                  60                  


Pro Pro Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr 
65                  70                  75                  80  


Tyr Leu Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr 
                85                  90                  95      


Lys Leu Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu 
            100                 105                 110         


Thr Ser Ile Val Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp 
        115                 120                 125             


Thr Glu Leu Lys Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro 
    130                 135                 140                 


Asp Gly Ser Tyr Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro 
145                 150                 155                 160 


Ser Ala Asp Ile Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val 
                165                 170                 175     


Leu Asn Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe 
            180                 185                 190         


Ser Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr 
        195                 200                 205             


Asn Pro Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr 
    210                 215                 220                 


Leu Ala His Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala 
225                 230                 235                 240 


Ile Asn Pro Asn Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu 
                245                 250                 255     


Met Ser Gly Leu Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly 
            260                 265                 270         


His Asp Ala Lys Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu 
        275                 280                 285             


Tyr Tyr Tyr Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala 
    290                 295                 300                 


Lys Ser Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val 
305                 310                 315                 320 


Phe Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser 
                325                 330                 335     


Val Asp Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile 
            340                 345                 350         


Tyr Thr Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu Asn Arg Lys 
        355                 360                 365             


Thr Tyr Leu Asn Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro 
    370                 375                 380                 


Lys Val Asn Tyr Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn 
385                 390                 395                 400 


Leu Ala Ala Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn 
                405                 410                 415     


Phe Thr Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu 
            420                 425                 430         


Leu Cys Val Arg Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Asp Lys 
        435                 440                 445             


Gly Tyr Asn Lys Ala Lys Ser Leu Val Pro Arg Gly Ser Gln Ala Leu 
    450                 455                 460                 


Asn Asp Leu Cys Ile Lys Val Asn Asn Trp Asp Leu Phe Phe Ser Pro 
465                 470                 475                 480 


Ser Glu Asp Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu Ile Thr 
                485                 490                 495     


Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu Asp Leu 
            500                 505                 510         


Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu Asn 
        515                 520                 525             


Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu Glu Leu 
    530                 535                 540                 


Met Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu Leu Asp 
545                 550                 555                 560 


Lys Tyr Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu His Gly 
                565                 570                 575     


Lys Ser Arg Ile Ala Leu Thr Asn Ser Val Asn Glu Ala Leu Leu Asn 
            580                 585                 590         


Pro Ser Arg Val Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys Lys Val 
        595                 600                 605             


Asn Lys Ala Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu Gln Leu 
    610                 615                 620                 


Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys 
625                 630                 635                 640 


Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn 
                645                 650                 655     


Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu Ile Phe 
            660                 665                 670         


Ser Gly Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala Ile Pro 
        675                 680                 685             


Val Leu Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys Val Leu 
    690                 695                 700                 


Thr Val Gln Thr Ile Asp Asn Ala Leu Ser Lys Arg Asn Glu Lys Trp 
705                 710                 715                 720 


Asp Glu Val Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys Val Asn 
                725                 730                 735     


Thr Gln Ile Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu Glu Asn 
            740                 745                 750         


Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr 
        755                 760                 765             


Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp Leu Ser 
    770                 775                 780                 


Ser Lys Leu Asn Glu Ser Ile Asn Lys Ala Met Ile Asn Ile Asn Lys 
785                 790                 795                 800 


Phe Leu Asn Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met Ile Pro 
                805                 810                 815     


Tyr Gly Val Lys Arg Leu Glu Asp Phe Asp Ala Ser Leu Lys Asp Ala 
            820                 825                 830         


Leu Leu Lys Tyr Ile Tyr Asp Asn Arg Gly Thr Leu Ile Gly Gln Val 
        835                 840                 845             


Asp Arg Leu Lys Asp Lys Val Asn Asn Thr Leu Ser Thr Asp Ile Pro 
    850                 855                 860                 


Phe Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser Thr Phe 
865                 870                 875                 880 


Thr Glu Tyr Ile Lys Asn Ile Arg Ser Glu Gly Arg His Lys Asp Ile 
                885                 890                 895     


Val Arg Leu Glu Ser Ser Ile Lys Glu Leu His Asp Met Phe Met Asp 
            900                 905                 910         


Ile Ala Met Leu Val Glu Asn Gln Gly Glu Met Leu Asp Asn Ile Glu 
        915                 920                 925             


Leu Asn Val Met His Thr Val Asp His Val Glu Lys Ala Arg Asp Glu 
    930                 935                 940                 


Thr Lys Arg Ala Gly 
945                 


<210>  20
<211>  988
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  20

Gly Ser Pro Gly Met Pro Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp 
1               5                   10                  15      


Pro Val Asn Gly Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly 
            20                  25                  30          


Gln Met Gln Pro Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val 
        35                  40                  45              


Ile Pro Glu Arg Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn 
    50                  55                  60                  


Pro Pro Pro Glu Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr 
65                  70                  75                  80  


Tyr Leu Ser Thr Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr 
                85                  90                  95      


Lys Leu Phe Glu Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu 
            100                 105                 110         


Thr Ser Ile Val Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp 
        115                 120                 125             


Thr Glu Leu Lys Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro 
    130                 135                 140                 


Asp Gly Ser Tyr Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro 
145                 150                 155                 160 


Ser Ala Asp Ile Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val 
                165                 170                 175     


Leu Asn Leu Thr Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe 
            180                 185                 190         


Ser Pro Asp Phe Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr 
        195                 200                 205             


Asn Pro Leu Leu Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr 
    210                 215                 220                 


Leu Ala His Glu Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala 
225                 230                 235                 240 


Ile Asn Pro Asn Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu 
                245                 250                 255     


Met Ser Gly Leu Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly 
            260                 265                 270         


His Asp Ala Lys Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu 
        275                 280                 285             


Tyr Tyr Tyr Asn Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala 
    290                 295                 300                 


Lys Ser Ile Val Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val 
305                 310                 315                 320 


Phe Lys Glu Lys Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser 
                325                 330                 335     


Val Asp Lys Leu Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile 
            340                 345                 350         


Tyr Thr Glu Asp Asn Phe Val Lys Phe Phe Lys Val Leu Asn Arg Lys 
        355                 360                 365             


Thr Tyr Leu Asn Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro 
    370                 375                 380                 


Lys Val Asn Tyr Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn 
385                 390                 395                 400 


Leu Ala Ala Asn Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn 
                405                 410                 415     


Phe Thr Lys Leu Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu 
            420                 425                 430         


Leu Cys Val Arg Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Asp Lys 
        435                 440                 445             


Gly Tyr Asn Lys Ala Lys Ser Leu Val Pro Arg Gly Ser Gln Ala Leu 
    450                 455                 460                 


Asn Asp Leu Cys Ile Lys Val Asn Asn Trp Asp Leu Phe Phe Ser Pro 
465                 470                 475                 480 


Ser Glu Asp Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu Ile Thr 
                485                 490                 495     


Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu Asp Leu 
            500                 505                 510         


Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro Glu Asn 
        515                 520                 525             


Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu Glu Leu 
    530                 535                 540                 


Met Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu Leu Asp 
545                 550                 555                 560 


Lys Tyr Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu His Gly 
                565                 570                 575     


Lys Ser Arg Ile Ala Leu Thr Asn Ser Val Asn Glu Ala Leu Leu Asn 
            580                 585                 590         


Pro Ser Arg Val Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys Lys Val 
        595                 600                 605             


Asn Lys Ala Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu Gln Leu 
    610                 615                 620                 


Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr Asp Lys 
625                 630                 635                 640 


Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala Leu Asn 
                645                 650                 655     


Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu Ile Phe 
            660                 665                 670         


Ser Gly Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala Ile Pro 
        675                 680                 685             


Val Leu Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys Val Leu 
    690                 695                 700                 


Thr Val Gln Thr Ile Asp Asn Ala Leu Ser Lys Arg Asn Glu Lys Trp 
705                 710                 715                 720 


Asp Glu Val Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys Val Asn 
                725                 730                 735     


Thr Gln Ile Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu Glu Asn 
            740                 745                 750         


Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn Gln Tyr 
        755                 760                 765             


Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp Leu Ser 
    770                 775                 780                 


Ser Lys Leu Asn Glu Ser Ile Asn Lys Ala Met Ile Asn Ile Asn Lys 
785                 790                 795                 800 


Phe Leu Asn Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met Ile Pro 
                805                 810                 815     


Tyr Gly Val Lys Arg Leu Glu Asp Phe Asp Ala Ser Leu Lys Asp Ala 
            820                 825                 830         


Leu Leu Lys Tyr Ile Tyr Asp Asn Arg Gly Thr Leu Ile Gly Gln Val 
        835                 840                 845             


Asp Arg Leu Lys Asp Lys Val Asn Asn Thr Leu Ser Thr Asp Ile Pro 
    850                 855                 860                 


Phe Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser Thr Phe 
865                 870                 875                 880 


Thr Glu Tyr Ile Lys Asn Ile Arg Ser Pro Glu Phe Met Ser Ala Thr 
                885                 890                 895     


Ala Ala Thr Val Pro Pro Ala Ala Pro Ala Gly Glu Gly Gly Pro Pro 
            900                 905                 910         


Ala Pro Pro Pro Asn Leu Thr Ser Asn Arg Arg Leu Gln Gln Thr Gln 
        915                 920                 925             


Ala Gln Val Asp Glu Val Val Asp Ile Met Arg Val Asn Val Asp Lys 
    930                 935                 940                 


Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp Arg Ala Asp 
945                 950                 955                 960 


Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala Ala Lys Leu 
                965                 970                 975     


Lys Arg Lys Tyr Ala Ala Ala Asn Leu Lys Met Met 
            980                 985             


<210>  21
<211>  73
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  21

Gly Ser Asn Leu Thr Ser Asn Arg Arg Leu Gln Gln Thr Gln Ala Gln 
1               5                   10                  15      


Val Asp Glu Val Val Asp Ile Met Arg Val Asn Val Asp Lys Val Leu 
            20                  25                  30          


Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp Arg Ala Asp Ala Leu 
        35                  40                  45              


Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala Ala Lys Leu Gly Ile 
    50                  55                  60                  


Leu Asp Ser Met Gly Ile Asn Thr Glu 
65                  70              


<210>  22
<211>  491
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  22

Gly Ser Asn Leu Thr Ser Asn Arg Arg Leu Gln Gln Thr Gln Ala Gln 
1               5                   10                  15      


Val Asp Glu Val Val Asp Ile Met Arg Val Asn Val Asp Lys Val Leu 
            20                  25                  30          


Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp Arg Ala Asp Ala Leu 
        35                  40                  45              


Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala Ala Lys Leu Gly Ile 
    50                  55                  60                  


Leu Asp Ser Met Ala Ser Ile Asn Asp Ser Lys Ile Leu Ser Leu Gln 
65                  70                  75                  80  


Asn Lys Lys Asn Ala Leu Val Asp Thr Ser Gly Tyr Asn Ala Glu Val 
                85                  90                  95      


Arg Val Gly Asp Asn Val Gln Leu Asn Thr Ile Tyr Thr Asn Asp Phe 
            100                 105                 110         


Lys Leu Ser Ser Ser Gly Asp Lys Ile Ile Val Asn Leu Asn Asn Asn 
        115                 120                 125             


Ile Leu Tyr Ser Ala Ile Tyr Glu Asn Ser Ser Val Ser Phe Trp Ile 
    130                 135                 140                 


Lys Ile Ser Lys Asp Leu Thr Asn Ser His Asn Glu Tyr Thr Ile Ile 
145                 150                 155                 160 


Asn Ser Ile Glu Gln Asn Ser Gly Trp Lys Leu Cys Ile Arg Asn Gly 
                165                 170                 175     


Asn Ile Glu Trp Ile Leu Gln Asp Val Asn Arg Lys Tyr Lys Ser Leu 
            180                 185                 190         


Ile Phe Asp Tyr Ser Glu Ser Leu Ser His Thr Gly Tyr Thr Asn Lys 
        195                 200                 205             


Trp Phe Phe Val Thr Ile Thr Asn Asn Ile Met Gly Tyr Met Lys Leu 
    210                 215                 220                 


Tyr Ile Asn Gly Glu Leu Lys Gln Ser Gln Lys Ile Glu Asp Leu Asp 
225                 230                 235                 240 


Glu Val Lys Leu Asp Lys Thr Ile Val Phe Gly Ile Asp Glu Asn Ile 
                245                 250                 255     


Asp Glu Asn Gln Met Leu Trp Ile Arg Asp Phe Asn Ile Phe Ser Lys 
            260                 265                 270         


Glu Leu Ser Asn Glu Asp Ile Asn Ile Val Tyr Glu Gly Gln Ile Leu 
        275                 280                 285             


Arg Asn Val Ile Lys Asp Tyr Trp Gly Asn Pro Leu Lys Phe Asp Thr 
    290                 295                 300                 


Glu Tyr Tyr Ile Ile Asn Asp Asn Tyr Ile Asp Arg Tyr Ile Ala Pro 
305                 310                 315                 320 


Glu Ser Asn Val Leu Val Leu Val Gln Tyr Pro Asp Arg Ser Lys Leu 
                325                 330                 335     


Tyr Thr Gly Asn Pro Ile Thr Ile Lys Ser Val Ser Asp Lys Asn Pro 
            340                 345                 350         


Tyr Ser Arg Ile Leu Asn Gly Asp Asn Ile Ile Leu His Met Leu Tyr 
        355                 360                 365             


Asn Ser Arg Lys Tyr Met Ile Ile Arg Asp Thr Asp Thr Ile Tyr Ala 
    370                 375                 380                 


Thr Gln Gly Gly Glu Cys Ser Gln Asn Cys Val Tyr Ala Leu Lys Leu 
385                 390                 395                 400 


Gln Ser Asn Leu Gly Asn Tyr Gly Ile Gly Ile Phe Ser Ile Lys Asn 
                405                 410                 415     


Ile Val Ser Lys Asn Lys Tyr Cys Ser Gln Ile Phe Ser Ser Phe Arg 
            420                 425                 430         


Glu Asn Thr Met Leu Leu Ala Asp Ile Tyr Lys Pro Trp Arg Phe Ser 
        435                 440                 445             


Phe Lys Asn Ala Tyr Thr Pro Val Ala Val Thr Asn Tyr Glu Thr Lys 
    450                 455                 460                 


Leu Leu Ser Thr Ser Ser Phe Trp Lys Phe Ile Ser Arg Asp Pro Gly 
465                 470                 475                 480 


Trp Val Glu Val Gly His His His His His His 
                485                 490     


<210>  23
<211>  588
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  23

Gly Ser Glu Gly Arg His Lys Asp Ile Val Arg Leu Glu Ser Ser Ile 
1               5                   10                  15      


Lys Glu Leu His Asp Met Phe Met Asp Ile Ala Met Leu Val Glu Asn 
            20                  25                  30          


Gln Gly Glu Met Leu Asp Asn Ile Glu Leu Asn Val Met His Thr Val 
        35                  40                  45              


Asp His Val Glu Lys Ala Arg Asp Glu Thr Lys Arg Ala Gly Ile Leu 
    50                  55                  60                  


Asp Ser Met Gly Arg Leu Glu Leu Lys Leu Met Ser Ala Thr Ala Ala 
65                  70                  75                  80  


Thr Val Pro Pro Ala Ala Pro Ala Gly Glu Gly Gly Pro Pro Ala Pro 
                85                  90                  95      


Pro Pro Asn Leu Thr Ser Asn Arg Arg Leu Gln Gln Thr Gln Ala Gln 
            100                 105                 110         


Val Asp Glu Val Val Asp Ile Met Arg Val Asn Val Asp Lys Val Leu 
        115                 120                 125             


Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp Arg Ala Asp Ala Leu 
    130                 135                 140                 


Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala Ala Lys Leu Gly Ile 
145                 150                 155                 160 


Leu Asp Ser Met Gly Ile Asn Thr Ser Ile Leu Asn Leu Arg Tyr Glu 
                165                 170                 175     


Ser Asn His Leu Ile Asp Leu Ser Arg Tyr Ala Ser Lys Ile Asn Ile 
            180                 185                 190         


Gly Ser Lys Val Asn Phe Asp Pro Ile Asp Lys Asn Gln Ile Gln Leu 
        195                 200                 205             


Phe Asn Leu Glu Ser Ser Lys Ile Glu Val Ile Leu Lys Asn Ala Ile 
    210                 215                 220                 


Val Tyr Asn Ser Met Tyr Glu Asn Phe Ser Thr Ser Phe Trp Ile Arg 
225                 230                 235                 240 


Ile Pro Lys Tyr Phe Asn Ser Ile Ser Leu Asn Asn Glu Tyr Thr Ile 
                245                 250                 255     


Ile Asn Cys Met Glu Asn Asn Ser Gly Trp Lys Val Ser Leu Asn Tyr 
            260                 265                 270         


Gly Glu Ile Ile Trp Thr Leu Gln Asp Thr Gln Glu Ile Lys Gln Arg 
        275                 280                 285             


Val Val Phe Lys Tyr Ser Gln Met Ile Asn Ile Ser Asp Tyr Ile Asn 
    290                 295                 300                 


Arg Trp Ile Phe Val Thr Ile Thr Asn Asn Arg Leu Asn Asn Ser Lys 
305                 310                 315                 320 


Ile Tyr Ile Asn Gly Arg Leu Ile Asp Gln Lys Pro Ile Ser Asn Leu 
                325                 330                 335     


Gly Asn Ile His Ala Ser Asn Asn Ile Met Phe Lys Leu Asp Gly Cys 
            340                 345                 350         


Arg Asp Thr His Arg Tyr Ile Trp Ile Lys Tyr Phe Asn Leu Phe Asp 
        355                 360                 365             


Lys Glu Leu Asn Glu Lys Glu Ile Lys Asp Leu Tyr Asp Asn Gln Ser 
    370                 375                 380                 


Asn Ser Gly Ile Leu Lys Asp Phe Trp Gly Asp Tyr Leu Gln Tyr Asp 
385                 390                 395                 400 


Lys Pro Tyr Tyr Met Leu Asn Leu Tyr Asp Pro Asn Lys Tyr Val Asp 
                405                 410                 415     


Val Asn Asn Val Gly Ile Arg Gly Tyr Met Tyr Leu Lys Gly Pro Arg 
            420                 425                 430         


Gly Ser Val Met Thr Thr Asn Ile Tyr Leu Asn Ser Ser Leu Tyr Arg 
        435                 440                 445             


Gly Thr Lys Phe Ile Ile Lys Lys Tyr Ala Ser Gly Asn Lys Asp Asn 
    450                 455                 460                 


Ile Val Arg Asn Asn Asp Arg Val Tyr Ile Asn Val Val Val Lys Asn 
465                 470                 475                 480 


Lys Glu Tyr Arg Leu Ala Thr Asn Ala Ser Gln Ala Gly Val Glu Lys 
                485                 490                 495     


Ile Leu Ser Ala Leu Glu Ile Pro Asp Val Gly Asn Leu Ser Gln Val 
            500                 505                 510         


Val Val Met Lys Ser Lys Asn Asp Gln Gly Ile Thr Asn Lys Cys Lys 
        515                 520                 525             


Met Asn Leu Gln Asp Asn Asn Gly Asn Asp Ile Gly Phe Ile Gly Phe 
    530                 535                 540                 


His Gln Phe Asn Asn Ile Ala Lys Leu Val Ala Ser Asn Trp Tyr Asn 
545                 550                 555                 560 


Arg Gln Ile Glu Arg Ser Ser Arg Thr Leu Gly Cys Ser Trp Glu Phe 
                565                 570                 575     


Ile Pro Val Asp Asp Gly Trp Gly Glu Arg Pro Leu 
            580                 585             


<210>  24
<211>  208
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  24

Gly Ser Met Ala Glu Asp Ala Asp Met Arg Asn Glu Leu Glu Glu Met 
1               5                   10                  15      


Gln Arg Arg Ala Asp Gln Leu Ala Asp Glu Ser Leu Glu Ser Thr Arg 
            20                  25                  30          


Arg Met Leu Gln Leu Val Glu Glu Ser Lys Asp Ala Gly Ile Arg Thr 
        35                  40                  45              


Leu Val Met Leu Asp Glu Gln Gly Glu Gln Leu Glu Arg Ile Glu Glu 
    50                  55                  60                  


Gly Met Asp Gln Ile Asn Lys Asp Met Lys Glu Ala Glu Lys Asn Leu 
65                  70                  75                  80  


Thr Asp Leu Gly Lys Phe Ala Gly Leu Ala Val Ala Pro Ala Asn Lys 
                85                  90                  95      


Leu Lys Ser Ser Asp Ala Tyr Lys Lys Ala Trp Gly Asn Asn Gln Asp 
            100                 105                 110         


Gly Val Val Ala Ser Gln Pro Ala Arg Val Val Asp Glu Arg Glu Gln 
        115                 120                 125             


Met Ala Ile Ser Gly Gly Phe Ile Arg Arg Val Thr Asn Asp Ala Arg 
    130                 135                 140                 


Glu Asn Glu Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile Ile Gly 
145                 150                 155                 160 


Asn Leu Arg His Met Ala Leu Asp Met Gly Asn Glu Ile Asp Thr Gln 
                165                 170                 175     


Asn Arg Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr 
            180                 185                 190         


Arg Ile Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly 
        195                 200                 205             


<210>  25
<211>  62
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  25

Gly Ser Glu Gly Arg His Lys Asp Ile Val Arg Leu Glu Ser Ser Ile 
1               5                   10                  15      


Lys Glu Leu His Asp Met Phe Met Asp Ile Ala Met Leu Val Glu Asn 
            20                  25                  30          


Gln Gly Glu Met Leu Asp Asn Ile Glu Leu Asn Val Met His Thr Val 
        35                  40                  45              


Asp His Val Glu Lys Ala Arg Asp Glu Thr Lys Arg Ala Gly 
    50                  55                  60          


<210>  26
<211>  56
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (41)..(42)
<223>  Xaa at positions 41 and 42 is Acp (6-aminocaproic acid)

<400>  26

Arg Leu Gln Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met 
1               5                   10                  15      


Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu 
            20                  25                  30          


Leu Asp Asp Arg Ala Asp Ala Leu Xaa Xaa Ala Gly Cys Lys Asn Phe 
        35                  40                  45              


Phe Trp Lys Thr Phe Thr Ser Cys 
    50                  55      


<210>  27
<211>  55
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  27

Arg Leu Gln Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met 
1               5                   10                  15      


Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu 
            20                  25                  30          


Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu 
        35                  40                  45              


Thr Ser Ala Ala Lys Leu Ala 
    50                  55  


<210>  28
<211>  49
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  28

Ala Gln Val Asp Glu Val Val Asp Ile Met Arg Val Asn Val Asp Lys 
1               5                   10                  15      


Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp Arg Ala Asp 
            20                  25                  30          


Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala Ala Lys Leu 
        35                  40                  45              


Ala 
    


<210>  29
<211>  42
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  29

Asp Ile Met Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys 
1               5                   10                  15      


Leu Ser Glu Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser 
            20                  25                  30          


Gln Phe Glu Thr Ser Ala Ala Lys Leu Ala 
        35                  40          


<210>  30
<211>  35
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  30

Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp Asp Arg 
1               5                   10                  15      


Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser Ala Ala 
            20                  25                  30          


Lys Leu Ala 
        35  


<210>  31
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  31

Lys Leu Ser Glu Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala 
1               5                   10                  15      


Ser Gln Phe Glu Thr Ser Ala Ala Lys Leu Ala 
            20                  25          


<210>  32
<211>  54
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  32

Glu Ile Ile Lys Leu Glu Asn Ser Ile Arg Glu Leu His Asp Met Phe 
1               5                   10                  15      


Met Asp Met Ala Met Leu Val Glu Ser Gln Gly Glu Met Ile Asp Arg 
            20                  25                  30          


Ile Glu Tyr Asn Val Glu His Ala Val Asp Tyr Val Glu Arg Ala Val 
        35                  40                  45              


Ser Asp Thr Lys Lys Ala 
    50                  


<210>  33
<211>  50
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (48)..(48)
<223>  Xaa at position 48 is Acp (6-aminocaproic acid)

<400>  33

Glu Ile Ile Arg Leu Glu Asn Ser Ile Arg Glu Leu His Asp Met Phe 
1               5                   10                  15      


Met Asp Met Ala Met Leu Val Glu Ser Gln Gly Glu Met Ile Asp Arg 
            20                  25                  30          


Ile Glu Tyr Asn Val Glu His Ala Val Asp Tyr Val Glu Arg Ala Xaa 
        35                  40                  45              


Lys Lys 
    50  


<210>  34
<211>  53
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (7)..(7)
<223>  Xaa at position 7 is Acp (6-aminocaproic acid)

<400>  34

His His His His His His Xaa Glu Ile Ile Arg Leu Glu Asn Ser Ile 
1               5                   10                  15      


Arg Glu Leu His Asp Met Phe Met Asp Met Ala Met Leu Val Glu Ser 
            20                  25                  30          


Gln Gly Glu Met Ile Asp Arg Ile Glu Tyr Asn Val Glu His Ala Val 
        35                  40                  45              


Asp Tyr Val Glu Cys 
    50              


<210>  35
<211>  52
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  35

Glu Ile Ile Lys Leu Glu Asn Ser Ile Arg Glu Leu His Asp Met Phe 
1               5                   10                  15      


Met Asp Met Ala Met Leu Val Glu Ser Gln Gly Glu Met Ile Asp Arg 
            20                  25                  30          


Ile Glu Tyr Asn Val Glu His Ala Gly Ser Gly Gly Gly His His His 
        35                  40                  45              


His His His Cys 
    50          


<210>  36
<211>  33
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  36

Gly Gly Glu Ile Ile Arg Leu Glu Asn Ser Ile Arg Glu Leu His Asp 
1               5                   10                  15      


Met Phe Met Asp Met Ala Met Leu Val Glu Ser Gln Gly Glu Met Ile 
            20                  25                  30          


Asp 
    


<210>  37
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  37

Glu Ile Ile Arg Leu Glu Asn Ser Ile Arg Glu Leu His Asp Met Phe 
1               5                   10                  15      


Met Asp Met Ala Met Leu Val Glu Ser Thr Gly Glu Met Ile Asp Arg 
            20                  25                  30          


Ile Glu Tyr Asn Val Glu His Ala 
        35                  40  


<210>  38
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  38

Asn Ser Ile Arg Glu Leu His Asp Met Phe Met Asp Met Ala Met Leu 
1               5                   10                  15      


Val Glu Ser Gln Gly Glu Met Ile Asp Arg Ile Glu Tyr Asn Val Glu 
            20                  25                  30          


His Ala Val Asp Tyr Val Glu Cys 
        35                  40  


<210>  39
<211>  45
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  39

Glu Ile Ile Lys Leu Glu Asn Ser Ile Arg Glu Leu His Asp Met Phe 
1               5                   10                  15      


Met Asp Met Ala Met Leu Val Glu Ser Gln Gly Glu Met Ile Asp Arg 
            20                  25                  30          


Ile Glu Tyr Asn Val Glu His Ala Val Asp Tyr Val Glu 
        35                  40                  45  


<210>  40
<211>  45
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (15)..(15)
<223>  Xaa at position 15 is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (17)..(17)
<223>  Xaa at position 17 is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (19)..(19)
<223>  Xaa at position 19 is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (21)..(21)
<223>  Xaa at position 21 is Nle (norleucine)

<220>
<221>  misc_feature
<222>  (29)..(29)
<223>  Xaa at position 29 is Nle (norleucine)

<400>  40

Glu Ile Ile Lys Leu Glu Asn Ser Ile Arg Glu Leu His Asp Xaa Phe 
1               5                   10                  15      


Xaa Asp Xaa Ala Xaa Leu Val Glu Ser Gln Gly Glu Xaa Ile Asp Arg 
            20                  25                  30          


Ile Glu Tyr Asn Val Glu His Ala Val Asp Tyr Val Glu 
        35                  40                  45  


<210>  41
<211>  211
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  41

Met Asp Asn Leu Ser Ser Glu Glu Ile Gln Gln Arg Ala His Gln Ile 
1               5                   10                  15      


Thr Asp Glu Ser Leu Glu Ser Thr Arg Arg Ile Leu Gly Leu Ala Ile 
            20                  25                  30          


Glu Ser Gln Asp Ala Gly Ile Lys Thr Ile Thr Met Leu Asp Glu Gln 
        35                  40                  45              


Lys Glu Gln Leu Asn Arg Ile Glu Glu Gly Leu Asp Gln Ile Asn Lys 
    50                  55                  60                  


Asp Met Arg Glu Thr Glu Lys Thr Leu Thr Glu Leu Asn Lys Cys Cys 
65                  70                  75                  80  


Gly Leu Cys Val Cys Pro Cys Asn Arg Thr Lys Asn Phe Glu Ser Gly 
                85                  90                  95      


Lys Ala Tyr Lys Thr Thr Trp Gly Asp Gly Gly Glu Asn Ser Pro Cys 
            100                 105                 110         


Asn Val Val Ser Lys Gln Pro Gly Pro Val Thr Asn Gly Gln Leu Gln 
        115                 120                 125             


Gln Pro Thr Thr Gly Ala Ala Ser Gly Gly Tyr Ile Lys Arg Ile Thr 
    130                 135                 140                 


Asn Asp Ala Arg Glu Asp Glu Met Glu Glu Asn Leu Thr Gln Val Gly 
145                 150                 155                 160 


Ser Ile Leu Gly Asn Leu Lys Asp Met Ala Leu Asn Ile Gly Asn Glu 
                165                 170                 175     


Ile Asp Ala Gln Asn Pro Gln Ile Lys Arg Ile Thr Asp Lys Ala Asp 
            180                 185                 190         


Thr Asn Arg Asp Arg Ile Asp Ile Ala Asn Ala Arg Ala Lys Lys Leu 
        195                 200                 205             


Ile Asp Ser 
    210     


<210>  42
<211>  114
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  42

Pro Pro Lys Phe Lys Arg His Leu Asn Asp Asp Asp Val Thr Gly Ser 
1               5                   10                  15      


Val Lys Ser Glu Arg Arg Asn Leu Leu Glu Asp Asp Ser Asp Glu Glu 
            20                  25                  30          


Glu Asp Phe Phe Leu Arg Gly Pro Ser Gly Pro Arg Phe Gly Pro Arg 
        35                  40                  45              


Asn Asp Lys Ile Lys His Val Gln Asn Gln Val Asp Glu Val Ile Asp 
    50                  55                  60                  


Val Met Gln Glu Asn Ile Thr Lys Val Ile Glu Arg Gly Glu Arg Leu 
65                  70                  75                  80  


Asp Glu Leu Gln Asp Lys Ser Glu Ser Leu Ser Asp Asn Ala Thr Ala 
                85                  90                  95      


Phe Ser Asn Arg Ser Lys Gln Leu Arg Arg Gln Met Trp Trp Arg Gly 
            100                 105                 110         


Cys Lys 
        


<210>  43
<211>  69
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  43

Ala Gly Lys Glu Leu Lys Gln Cys Gln Gln Gln Ala Asp Glu Val Thr 
1               5                   10                  15      


Glu Ile Met Leu Asn Asn Phe Asp Lys Val Leu Glu Arg His Gly Lys 
            20                  25                  30          


Leu Ala Glu Leu Glu Gln Arg Ser Asp Gln Leu Leu Asp Met Ser Ser 
        35                  40                  45              


Ala Phe Ser Lys Thr Thr Lys Thr Leu Ala Gln Gln Lys Arg Trp Glu 
    50                  55                  60                  


Asn Ile Arg Cys Arg 
65                  


<210>  44
<211>  187
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  44

Ala Ile Leu Phe Ala Val Val Ala Arg Gly Thr Thr Ile Leu Ala Lys 
1               5                   10                  15      


His Ala Trp Cys Gly Gly Asn Phe Leu Glu Val Thr Glu Gln Ile Leu 
            20                  25                  30          


Ala Lys Ile Pro Ser Glu Asn Asn Lys Leu Thr Tyr Ser His Gly Asn 
        35                  40                  45              


Tyr Leu Phe His Tyr Ile Cys Gln Asp Arg Ile Val Tyr Leu Cys Ile 
    50                  55                  60                  


Thr Asp Asp Asp Phe Glu Arg Ser Arg Ala Phe Ser Phe Leu Asn Glu 
65                  70                  75                  80  


Val Lys Lys Arg Phe Gln Thr Thr Tyr Gly Ser Arg Ala Gln Thr Ala 
                85                  90                  95      


Leu Pro Tyr Ala Met Asn Ser Glu Phe Ser Ser Val Leu Ala Ala Gln 
            100                 105                 110         


Leu Lys His His Ser Glu Asn Lys Ser Leu Asp Lys Val Met Glu Thr 
        115                 120                 125             


Gln Ala Gln Val Asp Glu Leu Lys Gly Ile Met Val Arg Asn Ile Asp 
    130                 135                 140                 


Leu Val Ala Gln Arg Gly Glu Arg Leu Glu Leu Leu Ile Asp Lys Thr 
145                 150                 155                 160 


Glu Asn Leu Val Asp Ser Ser Val Thr Phe Lys Thr Thr Ser Arg Asn 
                165                 170                 175     


Leu Ala Arg Ala Met Cys Met Lys Asn Ile Lys 
            180                 185         


<210>  45
<211>  74
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  45

Glu Glu Ala Ser Gly Ser Ala Gly Asn Asp Arg Val Arg Asn Leu Gln 
1               5                   10                  15      


Ser Glu Val Glu Gly Val Lys Asn Ile Met Thr Gln Asn Val Glu Arg 
            20                  25                  30          


Ile Leu Ser Arg Gly Glu Asn Leu Asp His Leu Arg Asn Lys Thr Glu 
        35                  40                  45              


Asp Leu Glu Ala Thr Ser Glu His Phe Lys Thr Thr Ser Gln Lys Val 
    50                  55                  60                  


Ala Arg Lys Phe Trp Trp Lys Asn Val Lys 
65                  70                  


<210>  46
<211>  45
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  46

Glu Ile Ile Arg Leu Glu Asn Ser Ile Arg Glu Leu His Asp Met Phe 
1               5                   10                  15      


Met Asp Met Ala Met Leu Val Glu Ser Gln Gly Glu Met Ile Asp Arg 
            20                  25                  30          


Ile Glu Tyr Asn Val Glu His Ala Val Asp Tyr Val Glu 
        35                  40                  45  


<210>  47
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  47

Glu Ile Ile Lys Leu Glu Asn Ser Ile Arg Glu Leu His Asp Met Phe 
1               5                   10                  15      


Met Asp Met Ala Met Leu Val Glu Ser Gln Gly Glu Met Ile Asp Arg 
            20                  25                  30          


Ile Glu Tyr Asn Val Glu His Ala 
        35                  40  


<210>  48
<211>  45
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  48

Ser Thr Arg Arg Met Leu Gln Leu Val Glu Glu Ser Lys Asp Ala Gly 
1               5                   10                  15      


Ile Arg Thr Leu Val Met Leu Asp Glu Gln Gly Glu Gln Leu Asp Arg 
            20                  25                  30          


Val Glu Glu Gly Met Asn His Ile Asn Gln Asp Met Lys 
        35                  40                  45  


<210>  49
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  49

Ser Thr Arg Arg Met Leu Gln Leu Val Glu Glu Ser Lys Asp Ala Gly 
1               5                   10                  15      


Ile Arg Thr Leu Val Met Leu Asp Glu Gln Gly Glu Gln Leu Asp Arg 
            20                  25                  30          


Val Glu Glu Gly Met Asn His Ile 
        35                  40  


<210>  50
<211>  45
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  50

Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu Arg His Met Ala 
1               5                   10                  15      


Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg Gln Ile Asp Arg 
            20                  25                  30          


Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile Asp 
        35                  40                  45  


<210>  51
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  51

Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu Arg His Met Ala 
1               5                   10                  15      


Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg Gln Ile Asp Arg 
            20                  25                  30          


Ile Met Glu Lys Ala Asp Ser Asn 
        35                  40  


<210>  52
<211>  45
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  52

Arg Leu Gln Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met 
1               5                   10                  15      


Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu 
            20                  25                  30          


Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser 
        35                  40                  45  


<210>  53
<211>  40
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  53

Arg Leu Gln Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met 
1               5                   10                  15      


Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu 
            20                  25                  30          


Leu Asp Asp Arg Ala Asp Ala Leu 
        35                  40  


<210>  54
<211>  56
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (41)..(42)
<223>  Xaa at positions 41 and 42 is Acp (6-aminocaproic acid)

<400>  54

Glu Ile Ile Lys Leu Glu Asn Ser Ile Arg Glu Leu His Asp Met Phe 
1               5                   10                  15      


Met Asp Met Ala Met Leu Val Glu Ser Gln Gly Glu Met Ile Asp Arg 
            20                  25                  30          


Ile Glu Tyr Asn Val Glu His Ala Xaa Xaa Ala Gly Cys Lys Asn Phe 
        35                  40                  45              


Phe Trp Lys Thr Phe Thr Ser Cys 
    50                  55      


<210>  55
<211>  56
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (41)..(42)
<223>  Xaa at positions 41 and 42 is Acp (6-aminocaproic acid)

<400>  55

Arg Leu Gln Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met 
1               5                   10                  15      


Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu 
            20                  25                  30          


Leu Asp Asp Arg Ala Asp Ala Leu Xaa Xaa Ala Gly Cys Lys Asn Phe 
        35                  40                  45              


Phe Trp Lys Thr Phe Thr Ser Cys 
    50                  55      


<210>  56
<211>  58
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (46)..(47)
<223>  Xaa at positions 46 and 47 is Acp (6-aminocaproic acid)

<400>  56

Glu Ile Ile Lys Leu Glu Asn Ser Ile Arg Glu Leu His Asp Met Phe 
1               5                   10                  15      


Met Asp Met Ala Met Leu Val Glu Ser Gln Gly Glu Met Ile Asp Arg 
            20                  25                  30          


Ile Glu Tyr Asn Val Glu His Ala Val Asp Tyr Val Glu Xaa Xaa Arg 
        35                  40                  45              


Pro Lys Pro Gln Gln Phe Phe Gly Leu Met 
    50                  55              


<210>  57
<211>  58
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (46)..(47)
<223>  Xaa at positions 46 and 47 is Acp (6-aminocaproic acid)

<400>  57

Arg Leu Gln Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met 
1               5                   10                  15      


Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu 
            20                  25                  30          


Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Xaa Xaa Arg 
        35                  40                  45              


Pro Lys Pro Gln Gln Phe Phe Gly Leu Met 
    50                  55              


<210>  58
<211>  58
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (48)..(49)
<223>  Xaa at positions 48 and 49 is Acp (6-aminocaproic acid)

<400>  58

Ala Glu Ile Ile Lys Leu Glu Asn Ser Ile Arg Glu Leu His Asp Met 
1               5                   10                  15      


Phe Met Asp Met Ala Met Leu Val Glu Ser Gln Gly Glu Met Ile Asp 
            20                  25                  30          


Arg Ile Glu Tyr Asn Val Glu His Ala Val Asp Tyr Val Glu Arg Xaa 
        35                  40                  45              


Xaa Cys Tyr Phe Gln Asn Cys Pro Arg Gly 
    50                  55              


<210>  59
<211>  57
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct


<220>
<221>  misc_feature
<222>  (10)..(11)
<223>  Xaa at positions 10 and 11 is Acp (6-aminocaproic acid)

<400>  59

Cys Tyr Phe Gln Asn Cys Pro Arg Gly Xaa Xaa Ala Glu Ile Ile Lys 
1               5                   10                  15      


Leu Glu Asn Ser Ile Arg Glu Leu His Asp Met Phe Met Asp Met Ala 
            20                  25                  30          


Met Leu Val Glu Ser Gln Gly Glu Met Ile Asp Arg Ile Glu Tyr Asn 
        35                  40                  45              


Val Glu His Ala Val Asp Tyr Val Glu 
    50                  55          


<210>  60
<211>  27
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  60

Glu Ile Ile Arg Leu Glu Asn Ser Ile Arg Glu Leu His Asp Met Phe 
1               5                   10                  15      


Met Asp Met Ala Met Leu Val Glu Ser Gln Gly 
            20                  25          


<210>  61
<211>  31
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  61

Glu Ile Ile Lys Leu Glu Asn Ser Ile Arg Glu Leu His Asp Met Phe 
1               5                   10                  15      


Met Asp Met Ala Met Leu Val Glu Ser Gln Gly Glu Met Ile Asp 
            20                  25                  30      


<210>  62
<211>  50
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  62

Ala Glu Asp Ala Glu Ile Ile Lys Leu Glu Asn Ser Ile Arg Glu Leu 
1               5                   10                  15      


His Asp Met Phe Met Asp Met Ala Met Leu Val Glu Ser Gln Gly Glu 
            20                  25                  30          


Met Ile Asp Arg Ile Glu Tyr Asn Val Glu His Ala Val Asp Tyr Val 
        35                  40                  45              


Glu Cys 
    50  


<210>  63
<211>  39
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  63

Glu Arg Lys Ala Lys Tyr Ala Lys Met Glu Ala Glu Arg Glu Val Met 
1               5                   10                  15      


Arg Gln Gly Ile Arg Asp Lys Tyr Gly Ile Lys Lys Gly Ser Gly Ser 
            20                  25                  30          


Gly Gly Ile Lys Val Ala Val 
        35                  


<210>  64
<211>  206
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  64

Met Ala Glu Asp Ala Asp Met Arg Asn Glu Leu Glu Glu Met Gln Arg 
1               5                   10                  15      


Arg Ala Asp Gln Leu Ala Asp Glu Ser Leu Glu Ser Thr Arg Arg Met 
            20                  25                  30          


Leu Gln Leu Val Glu Glu Ser Lys Asp Ala Gly Ile Arg Thr Leu Val 
        35                  40                  45              


Met Leu Asp Glu Gln Gly Glu Gln Leu Glu Arg Ile Glu Glu Gly Met 
    50                  55                  60                  


Asp Gln Ile Asn Lys Asp Met Lys Glu Ala Glu Lys Asn Leu Thr Asp 
65                  70                  75                  80  


Leu Gly Lys Phe Ala Gly Leu Ala Val Ala Pro Ala Asn Lys Leu Lys 
                85                  90                  95      


Ser Ser Asp Ala Tyr Lys Lys Ala Trp Gly Asn Asn Gln Asp Gly Val 
            100                 105                 110         


Val Ala Ser Gln Pro Ala Arg Val Val Asp Glu Arg Glu Gln Met Ala 
        115                 120                 125             


Ile Ser Gly Gly Phe Ile Arg Arg Val Thr Asn Asp Ala Arg Glu Asn 
    130                 135                 140                 


Glu Met Asp Glu Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu 
145                 150                 155                 160 


Arg His Met Ala Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg 
                165                 170                 175     


Gln Ile Asp Arg Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile 
            180                 185                 190         


Asp Glu Ala Asn Gln Arg Ala Thr Lys Met Leu Gly Ser Gly 
        195                 200                 205     


<210>  65
<211>  211
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  65

Met Asp Asn Leu Ser Ser Glu Glu Ile Gln Gln Arg Ala His Gln Ile 
1               5                   10                  15      


Thr Asp Glu Ser Leu Glu Ser Thr Arg Arg Ile Leu Gly Leu Ala Ile 
            20                  25                  30          


Glu Ser Gln Asp Ala Gly Ile Lys Thr Ile Thr Met Leu Asp Glu Gln 
        35                  40                  45              


Lys Glu Gln Leu Asn Arg Ile Glu Glu Gly Leu Asp Gln Ile Asn Lys 
    50                  55                  60                  


Asp Met Arg Glu Thr Glu Lys Thr Leu Thr Glu Leu Asn Lys Cys Cys 
65                  70                  75                  80  


Gly Leu Cys Val Cys Pro Cys Asn Arg Thr Lys Asn Phe Glu Ser Gly 
                85                  90                  95      


Lys Ala Tyr Lys Thr Thr Trp Gly Asp Gly Gly Glu Asn Ser Pro Cys 
            100                 105                 110         


Asn Val Val Ser Lys Gln Pro Gly Pro Val Thr Asn Gly Gln Leu Gln 
        115                 120                 125             


Gln Pro Thr Thr Gly Ala Ala Ser Gly Gly Tyr Ile Lys Arg Ile Thr 
    130                 135                 140                 


Asn Asp Ala Arg Glu Asp Glu Met Glu Glu Asn Leu Thr Gln Val Gly 
145                 150                 155                 160 


Ser Ile Leu Gly Asn Leu Lys Asp Met Ala Leu Asn Ile Gly Asn Glu 
                165                 170                 175     


Ile Asp Ala Gln Asn Pro Gln Ile Lys Arg Ile Thr Asp Lys Ala Asp 
            180                 185                 190         


Thr Asn Arg Asp Arg Ile Asp Ile Ala Asn Ala Arg Ala Lys Lys Leu 
        195                 200                 205             


Ile Asp Ser 
    210     


<210>  66
<211>  59
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  66

Glu Gly Arg His Lys Asp Ile Val Arg Leu Glu Ser Ser Ile Lys Glu 
1               5                   10                  15      


Leu His Asp Met Phe Met Asp Ile Ala Met Leu Val Glu Asn Gln Gly 
            20                  25                  30          


Glu Met Leu Asp Asn Ile Glu Leu Asn Val Met His Thr Val Asp His 
        35                  40                  45              


Val Glu Lys Ala Arg Asp Glu Thr Lys Arg Ala 
    50                  55                  


<210>  67
<211>  96
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  67

Met Ser Ala Thr Ala Ala Thr Val Pro Pro Ala Ala Pro Ala Gly Glu 
1               5                   10                  15      


Gly Gly Pro Pro Ala Pro Pro Pro Asn Leu Thr Ser Asn Arg Arg Leu 
            20                  25                  30          


Gln Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met Arg Val 
        35                  40                  45              


Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp 
    50                  55                  60                  


Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser 
65                  70                  75                  80  


Ala Ala Lys Leu Lys Arg Lys Tyr Ala Ala Ala Asn Leu Lys Met Met 
                85                  90                  95      


<210>  68
<211>  60
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  68

Asn Leu Thr Ser Asn Arg Arg Leu Gln Gln Thr Gln Ala Gln Val Asp 
1               5                   10                  15      


Glu Val Val Asp Ile Met Arg Val Asn Val Asp Lys Val Leu Glu Arg 
            20                  25                  30          


Asp Gln Lys Leu Ser Glu Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala 
        35                  40                  45              


Gly Ala Ser Gln Phe Glu Thr Ser Ala Ala Lys Leu 
    50                  55                  60  


<210>  69
<211>  84
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  69

Met Ser Ala Thr Ala Ala Thr Val Pro Pro Ala Ala Pro Ala Gly Glu 
1               5                   10                  15      


Gly Gly Pro Pro Ala Pro Pro Pro Asn Leu Thr Ser Asn Arg Arg Leu 
            20                  25                  30          


Gln Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met Arg Val 
        35                  40                  45              


Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu Leu Asp 
    50                  55                  60                  


Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu Thr Ser 
65                  70                  75                  80  


Ala Ala Lys Leu 
                


<210>  70
<211>  449
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  70

Met Pro Phe Val Asn Lys Gln Phe Asn Tyr Lys Asp Pro Val Asn Gly 
1               5                   10                  15      


Val Asp Ile Ala Tyr Ile Lys Ile Pro Asn Ala Gly Gln Met Gln Pro 
            20                  25                  30          


Val Lys Ala Phe Lys Ile His Asn Lys Ile Trp Val Ile Pro Glu Arg 
        35                  40                  45              


Asp Thr Phe Thr Asn Pro Glu Glu Gly Asp Leu Asn Pro Pro Pro Glu 
    50                  55                  60                  


Ala Lys Gln Val Pro Val Ser Tyr Tyr Asp Ser Thr Tyr Leu Ser Thr 
65                  70                  75                  80  


Asp Asn Glu Lys Asp Asn Tyr Leu Lys Gly Val Thr Lys Leu Phe Glu 
                85                  90                  95      


Arg Ile Tyr Ser Thr Asp Leu Gly Arg Met Leu Leu Thr Ser Ile Val 
            100                 105                 110         


Arg Gly Ile Pro Phe Trp Gly Gly Ser Thr Ile Asp Thr Glu Leu Lys 
        115                 120                 125             


Val Ile Asp Thr Asn Cys Ile Asn Val Ile Gln Pro Asp Gly Ser Tyr 
    130                 135                 140                 


Arg Ser Glu Glu Leu Asn Leu Val Ile Ile Gly Pro Ser Ala Asp Ile 
145                 150                 155                 160 


Ile Gln Phe Glu Cys Lys Ser Phe Gly His Glu Val Leu Asn Leu Thr 
                165                 170                 175     


Arg Asn Gly Tyr Gly Ser Thr Gln Tyr Ile Arg Phe Ser Pro Asp Phe 
            180                 185                 190         


Thr Phe Gly Phe Glu Glu Ser Leu Glu Val Asp Thr Asn Pro Leu Leu 
        195                 200                 205             


Gly Ala Gly Lys Phe Ala Thr Asp Pro Ala Val Thr Leu Ala His Glu 
    210                 215                 220                 


Leu Ile His Ala Gly His Arg Leu Tyr Gly Ile Ala Ile Asn Pro Asn 
225                 230                 235                 240 


Arg Val Phe Lys Val Asn Thr Asn Ala Tyr Tyr Glu Met Ser Gly Leu 
                245                 250                 255     


Glu Val Ser Phe Glu Glu Leu Arg Thr Phe Gly Gly His Asp Ala Lys 
            260                 265                 270         


Phe Ile Asp Ser Leu Gln Glu Asn Glu Phe Arg Leu Tyr Tyr Tyr Asn 
        275                 280                 285             


Lys Phe Lys Asp Ile Ala Ser Thr Leu Asn Lys Ala Lys Ser Ile Val 
    290                 295                 300                 


Gly Thr Thr Ala Ser Leu Gln Tyr Met Lys Asn Val Phe Lys Glu Lys 
305                 310                 315                 320 


Tyr Leu Leu Ser Glu Asp Thr Ser Gly Lys Phe Ser Val Asp Lys Leu 
                325                 330                 335     


Lys Phe Asp Lys Leu Tyr Lys Met Leu Thr Glu Ile Tyr Thr Glu Asp 
            340                 345                 350         


Asn Phe Val Lys Phe Phe Lys Val Leu Asn Arg Lys Thr Tyr Leu Asn 
        355                 360                 365             


Phe Asp Lys Ala Val Phe Lys Ile Asn Ile Val Pro Lys Val Asn Tyr 
    370                 375                 380                 


Thr Ile Tyr Asp Gly Phe Asn Leu Arg Asn Thr Asn Leu Ala Ala Asn 
385                 390                 395                 400 


Phe Asn Gly Gln Asn Thr Glu Ile Asn Asn Met Asn Phe Thr Lys Leu 
                405                 410                 415     


Lys Asn Phe Thr Gly Leu Phe Glu Phe Tyr Lys Leu Leu Cys Val Arg 
            420                 425                 430         


Gly Ile Ile Thr Ser Lys Thr Lys Ser Leu Asp Lys Gly Tyr Asn Lys 
        435                 440                 445             


Ala 
    


<210>  71
<211>  425
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  71

Ala Leu Asn Asp Leu Cys Ile Lys Val Asn Asn Trp Asp Leu Phe Phe 
1               5                   10                  15      


Ser Pro Ser Glu Asp Asn Phe Thr Asn Asp Leu Asn Lys Gly Glu Glu 
            20                  25                  30          


Ile Thr Ser Asp Thr Asn Ile Glu Ala Ala Glu Glu Asn Ile Ser Leu 
        35                  40                  45              


Asp Leu Ile Gln Gln Tyr Tyr Leu Thr Phe Asn Phe Asp Asn Glu Pro 
    50                  55                  60                  


Glu Asn Ile Ser Ile Glu Asn Leu Ser Ser Asp Ile Ile Gly Gln Leu 
65                  70                  75                  80  


Glu Leu Met Pro Asn Ile Glu Arg Phe Pro Asn Gly Lys Lys Tyr Glu 
                85                  90                  95      


Leu Asp Lys Tyr Thr Met Phe His Tyr Leu Arg Ala Gln Glu Phe Glu 
            100                 105                 110         


His Gly Lys Ser Arg Ile Ala Leu Thr Asn Ser Val Asn Glu Ala Leu 
        115                 120                 125             


Leu Asn Pro Ser Arg Val Tyr Thr Phe Phe Ser Ser Asp Tyr Val Lys 
    130                 135                 140                 


Lys Val Asn Lys Ala Thr Glu Ala Ala Met Phe Leu Gly Trp Val Glu 
145                 150                 155                 160 


Gln Leu Val Tyr Asp Phe Thr Asp Glu Thr Ser Glu Val Ser Thr Thr 
                165                 170                 175     


Asp Lys Ile Ala Asp Ile Thr Ile Ile Ile Pro Tyr Ile Gly Pro Ala 
            180                 185                 190         


Leu Asn Ile Gly Asn Met Leu Tyr Lys Asp Asp Phe Val Gly Ala Leu 
        195                 200                 205             


Ile Phe Ser Gly Ala Val Ile Leu Leu Glu Phe Ile Pro Glu Ile Ala 
    210                 215                 220                 


Ile Pro Val Leu Gly Thr Phe Ala Leu Val Ser Tyr Ile Ala Asn Lys 
225                 230                 235                 240 


Val Leu Thr Val Gln Thr Ile Asp Asn Ala Leu Ser Lys Arg Asn Glu 
                245                 250                 255     


Lys Trp Asp Glu Val Tyr Lys Tyr Ile Val Thr Asn Trp Leu Ala Lys 
            260                 265                 270         


Val Asn Thr Gln Ile Asp Leu Ile Arg Lys Lys Met Lys Glu Ala Leu 
        275                 280                 285             


Glu Asn Gln Ala Glu Ala Thr Lys Ala Ile Ile Asn Tyr Gln Tyr Asn 
    290                 295                 300                 


Gln Tyr Thr Glu Glu Glu Lys Asn Asn Ile Asn Phe Asn Ile Asp Asp 
305                 310                 315                 320 


Leu Ser Ser Lys Leu Asn Glu Ser Ile Asn Lys Ala Met Ile Asn Ile 
                325                 330                 335     


Asn Lys Phe Leu Asn Gln Cys Ser Val Ser Tyr Leu Met Asn Ser Met 
            340                 345                 350         


Ile Pro Tyr Gly Val Lys Arg Leu Glu Asp Phe Asp Ala Ser Leu Lys 
        355                 360                 365             


Asp Ala Leu Leu Lys Tyr Ile Tyr Asp Asn Arg Gly Thr Leu Ile Gly 
    370                 375                 380                 


Gln Val Asp Arg Leu Lys Asp Lys Val Asn Asn Thr Leu Ser Thr Asp 
385                 390                 395                 400 


Ile Pro Phe Gln Leu Ser Lys Tyr Val Asp Asn Gln Arg Leu Leu Ser 
                405                 410                 415     


Thr Phe Thr Glu Tyr Ile Lys Asn Ile 
            420                 425 


<210>  72
<211>  420
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  72

Ser Ile Leu Asn Leu Arg Tyr Glu Ser Asn His Leu Ile Asp Leu Ser 
1               5                   10                  15      


Arg Tyr Ala Ser Lys Ile Asn Ile Gly Ser Lys Val Asn Phe Asp Pro 
            20                  25                  30          


Ile Asp Lys Asn Gln Ile Gln Leu Phe Asn Leu Glu Ser Ser Lys Ile 
        35                  40                  45              


Glu Val Ile Leu Lys Asn Ala Ile Val Tyr Asn Ser Met Tyr Glu Asn 
    50                  55                  60                  


Phe Ser Thr Ser Phe Trp Ile Arg Ile Pro Lys Tyr Phe Asn Ser Ile 
65                  70                  75                  80  


Ser Leu Asn Asn Glu Tyr Thr Ile Ile Asn Cys Met Glu Asn Asn Ser 
                85                  90                  95      


Gly Trp Lys Val Ser Leu Asn Tyr Gly Glu Ile Ile Trp Thr Leu Gln 
            100                 105                 110         


Asp Thr Gln Glu Ile Lys Gln Arg Val Val Phe Lys Tyr Ser Gln Met 
        115                 120                 125             


Ile Asn Ile Ser Asp Tyr Ile Asn Arg Trp Ile Phe Val Thr Ile Thr 
    130                 135                 140                 


Asn Asn Arg Leu Asn Asn Ser Lys Ile Tyr Ile Asn Gly Arg Leu Ile 
145                 150                 155                 160 


Asp Gln Lys Pro Ile Ser Asn Leu Gly Asn Ile His Ala Ser Asn Asn 
                165                 170                 175     


Ile Met Phe Lys Leu Asp Gly Cys Arg Asp Thr His Arg Tyr Ile Trp 
            180                 185                 190         


Ile Lys Tyr Phe Asn Leu Phe Asp Lys Glu Leu Asn Glu Lys Glu Ile 
        195                 200                 205             


Lys Asp Leu Tyr Asp Asn Gln Ser Asn Ser Gly Ile Leu Lys Asp Phe 
    210                 215                 220                 


Trp Gly Asp Tyr Leu Gln Tyr Asp Lys Pro Tyr Tyr Met Leu Asn Leu 
225                 230                 235                 240 


Tyr Asp Pro Asn Lys Tyr Val Asp Val Asn Asn Val Gly Ile Arg Gly 
                245                 250                 255     


Tyr Met Tyr Leu Lys Gly Pro Arg Gly Ser Val Met Thr Thr Asn Ile 
            260                 265                 270         


Tyr Leu Asn Ser Ser Leu Tyr Arg Gly Thr Lys Phe Ile Ile Lys Lys 
        275                 280                 285             


Tyr Ala Ser Gly Asn Lys Asp Asn Ile Val Arg Asn Asn Asp Arg Val 
    290                 295                 300                 


Tyr Ile Asn Val Val Val Lys Asn Lys Glu Tyr Arg Leu Ala Thr Asn 
305                 310                 315                 320 


Ala Ser Gln Ala Gly Val Glu Lys Ile Leu Ser Ala Leu Glu Ile Pro 
                325                 330                 335     


Asp Val Gly Asn Leu Ser Gln Val Val Val Met Lys Ser Lys Asn Asp 
            340                 345                 350         


Gln Gly Ile Thr Asn Lys Cys Lys Met Asn Leu Gln Asp Asn Asn Gly 
        355                 360                 365             


Asn Asp Ile Gly Phe Ile Gly Phe His Gln Phe Asn Asn Ile Ala Lys 
    370                 375                 380                 


Leu Val Ala Ser Asn Trp Tyr Asn Arg Gln Ile Glu Arg Ser Ser Arg 
385                 390                 395                 400 


Thr Leu Gly Cys Ser Trp Glu Phe Ile Pro Val Asp Asp Gly Trp Gly 
                405                 410                 415     


Glu Arg Pro Leu 
            420 


<210>  73
<211>  118
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  73

Gly Ser Glu Gly Arg His Lys Asp Ile Val Arg Leu Glu Ser Ser Ile 
1               5                   10                  15      


Lys Glu Leu His Asp Met Phe Met Asp Ile Ala Met Leu Val Glu Asn 
            20                  25                  30          


Gln Gly Glu Met Leu Asp Asn Ile Glu Leu Asn Val Met His Thr Val 
        35                  40                  45              


Asp His Val Glu Lys Ala Arg Asp Glu Ala Lys Arg Ala Gly Asn Arg 
    50                  55                  60                  


Arg Leu Gln Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met 
65                  70                  75                  80  


Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu 
                85                  90                  95      


Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu 
            100                 105                 110         


Thr Ser Ala Ala Lys Leu 
        115             


<210>  74
<211>  55
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  74

Arg Leu Gln Gln Thr Gln Ala Gln Val Asp Glu Val Val Asp Ile Met 
1               5                   10                  15      


Arg Val Asn Val Asp Lys Val Leu Glu Arg Asp Gln Lys Leu Ser Glu 
            20                  25                  30          


Leu Asp Asp Arg Ala Asp Ala Leu Gln Ala Gly Ala Ser Gln Phe Glu 
        35                  40                  45              


Thr Ser Ala Ala Lys Leu Lys 
    50                  55  


<210>  75
<211>  55
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  75

Glu Ile Ile Lys Leu Glu Asn Ser Ile Arg Glu Leu His Asp Met Phe 
1               5                   10                  15      


Met Asp Met Ala Met Leu Val Glu Ser Gln Gly Glu Met Ile Asp Arg 
            20                  25                  30          


Ile Glu Tyr Asn Val Glu His Ala Val Asp Tyr Val Glu Arg Ala Val 
        35                  40                  45              


Ser Asp Thr Lys Lys Ala Val 
    50                  55  


<210>  76
<211>  55
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  76

Ser Thr Arg Arg Met Leu Gln Leu Val Glu Glu Ser Lys Asp Ala Gly 
1               5                   10                  15      


Ile Arg Thr Leu Val Met Leu Asp Glu Gln Gly Glu Gln Leu Asp Arg 
            20                  25                  30          


Val Glu Glu Gly Met Asn His Ile Asn Gln Asp Met Lys Glu Ala Glu 
        35                  40                  45              


Lys Asn Leu Lys Asp Leu Gly 
    50                  55  


<210>  77
<211>  55
<212>  PRT
<213>  Artificial sequence

<220>
<223>  Synthetic construct

<400>  77

Asn Leu Glu Gln Val Ser Gly Ile Ile Gly Asn Leu Arg His Met Ala 
1               5                   10                  15      


Leu Asp Met Gly Asn Glu Ile Asp Thr Gln Asn Arg Gln Ile Asp Arg 
            20                  25                  30          


Ile Met Glu Lys Ala Asp Ser Asn Lys Thr Arg Ile Asp Glu Ala Asn 
        35                  40                  45              


Gln Arg Ala Thr Lys Met Leu 
    50                  55  


