                         SEQUENCE LISTING

<110>  UNIVERSITTSKLINIKUM FREIBURG
 
<120>  Methods and compounds for the diagnosis and treatment of cancer

<130>  U7204/DB

<150>  EP09167060.4
<151>  2009-08-03

<160>  21    

<170>  PatentIn version 3.3

<210>  1
<211>  25
<212>  RNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide; RNA or DNA

<400>  1
uuuagcaucu cuuacgagga caaug                                           25


<210>  2
<211>  21
<212>  RNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide; RNA or DNA

<400>  2
uuacguaggg aucugacagg c                                               21


<210>  3
<211>  25
<212>  RNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  3
cauuccuaug cgagacguau guaaa                                           25


<210>  4
<211>  25
<212>  RNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  4
cauuguccuc guaagagaug cuaaa                                           25


<210>  5
<211>  64
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  5
cctgttacgt agggatgaca ggcgtcagtc agtggccaaa acgcctgtca gatccctacg     60

taac                                                                  64


<210>  6
<211>  64
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  6
tgctgttacg tagggatctg acaggcgttt tggccactga ctgacgcctg tcatccctac     60

gtaa                                                                  64


<210>  7
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  7

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Cys Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  8
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  8

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ala 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ser Ala Val Met Ala Leu Gln Glu Ala 
                85                  90                  95      


Ser Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  9
<211>  136
<212>  PRT
<213>  Homo sapiens

<400>  9

Met Ala Arg Thr Lys Gln Thr Ala Arg Lys Ser Thr Gly Gly Lys Ala 
1               5                   10                  15      


Pro Arg Lys Gln Leu Ala Thr Lys Ala Ala Arg Lys Ser Ala Pro Ser 
            20                  25                  30          


Thr Gly Gly Val Lys Lys Pro His Arg Tyr Arg Pro Gly Thr Val Ala 
        35                  40                  45              


Leu Arg Glu Ile Arg Arg Tyr Gln Lys Ser Thr Glu Leu Leu Ile Arg 
    50                  55                  60                  


Lys Leu Pro Phe Gln Arg Leu Val Arg Glu Ile Ala Gln Asp Phe Lys 
65                  70                  75                  80  


Thr Asp Leu Arg Phe Gln Ser Ala Ala Ile Gly Ala Leu Gln Glu Ala 
                85                  90                  95      


Ser Glu Ala Tyr Leu Val Gly Leu Phe Glu Asp Thr Asn Leu Cys Ala 
            100                 105                 110         


Ile His Ala Lys Arg Val Thr Ile Met Pro Lys Asp Ile Gln Leu Ala 
        115                 120                 125             


Arg Arg Ile Arg Gly Glu Arg Ala 
    130                 135     


<210>  10
<211>  671
<212>  PRT
<213>  Homo sapiens

<400>  10

Met Ala Asp Pro Ala Ala Gly Pro Pro Pro Ser Glu Gly Glu Glu Ser 
1               5                   10                  15      


Thr Val Arg Phe Ala Arg Lys Gly Ala Leu Arg Gln Lys Asn Val His 
            20                  25                  30          


Glu Val Lys Asn His Lys Phe Thr Ala Arg Phe Phe Lys Gln Pro Thr 
        35                  40                  45              


Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly 
    50                  55                  60                  


Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu 
65                  70                  75                  80  


Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Ala Ser Asp 
                85                  90                  95      


Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Ser Ser Pro 
            100                 105                 110         


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln 
        115                 120                 125             


Gly Met Lys Cys Asp Thr Cys Met Met Asn Val His Lys Arg Cys Val 
    130                 135                 140                 


Met Asn Val Pro Ser Leu Cys Gly Thr Asp His Thr Glu Arg Arg Gly 
145                 150                 155                 160 


Arg Ile Tyr Ile Gln Ala His Ile Asp Arg Asp Val Leu Ile Val Leu 
                165                 170                 175     


Val Arg Asp Ala Lys Asn Leu Val Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Ser Glu Ser 
        195                 200                 205             


Lys Gln Lys Thr Lys Thr Ile Lys Cys Ser Leu Asn Pro Glu Trp Asn 
    210                 215                 220                 


Glu Thr Phe Arg Phe Gln Leu Lys Glu Ser Asp Lys Asp Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Ile Trp Asp Trp Asp Leu Thr Ser Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ser Leu Ser Phe Gly Ile Ser Glu Leu Gln Lys Ala Ser Val Asp 
            260                 265                 270         


Gly Trp Phe Lys Leu Leu Ser Gln Glu Glu Gly Glu Tyr Phe Asn Val 
        275                 280                 285             


Pro Val Pro Pro Glu Gly Ser Glu Ala Asn Glu Glu Leu Arg Gln Lys 
    290                 295                 300                 


Phe Glu Arg Ala Lys Ile Ser Gln Gly Thr Lys Val Pro Glu Glu Lys 
305                 310                 315                 320 


Thr Thr Asn Thr Val Ser Lys Phe Asp Asn Asn Gly Asn Arg Asp Arg 
                325                 330                 335     


Met Lys Leu Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser 
            340                 345                 350         


Phe Gly Lys Val Met Leu Ser Glu Arg Lys Gly Thr Asp Glu Leu Tyr 
        355                 360                 365             


Ala Val Lys Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val 
    370                 375                 380                 


Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala Leu Pro Gly Lys Pro 
385                 390                 395                 400 


Pro Phe Leu Thr Gln Leu His Ser Cys Phe Gln Thr Met Asp Arg Leu 
                405                 410                 415     


Tyr Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile 
            420                 425                 430         


Gln Gln Val Gly Arg Phe Lys Glu Pro His Ala Val Phe Tyr Ala Ala 
        435                 440                 445             


Glu Ile Ala Ile Gly Leu Phe Phe Leu Gln Ser Lys Gly Ile Ile Tyr 
    450                 455                 460                 


Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile 
465                 470                 475                 480 


Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn Ile Trp Asp Gly Val 
                485                 490                 495     


Thr Thr Lys Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile 
            500                 505                 510         


Ile Ala Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Phe Gly 
        515                 520                 525             


Val Leu Leu Tyr Glu Met Leu Ala Gly Gln Ala Pro Phe Glu Gly Glu 
    530                 535                 540                 


Asp Glu Asp Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ala Tyr 
545                 550                 555                 560 


Pro Lys Ser Met Ser Lys Glu Ala Val Ala Ile Cys Lys Gly Leu Met 
                565                 570                 575     


Thr Lys His Pro Gly Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg 
            580                 585                 590         


Asp Ile Lys Glu His Ala Phe Phe Arg Tyr Ile Asp Trp Glu Lys Leu 
        595                 600                 605             


Glu Arg Lys Glu Ile Gln Pro Pro Tyr Lys Pro Lys Ala Arg Asp Lys 
    610                 615                 620                 


Arg Asp Thr Ser Asn Phe Asp Lys Glu Phe Thr Arg Gln Pro Val Glu 
625                 630                 635                 640 


Leu Thr Pro Thr Asp Lys Leu Phe Ile Met Asn Leu Asp Gln Asn Glu 
                645                 650                 655     


Phe Ala Gly Phe Ser Tyr Thr Asn Pro Glu Phe Val Ile Asn Val 
            660                 665                 670     


<210>  11
<211>  2711
<212>  DNA
<213>  Homo sapiens

<400>  11
agctggacga gcggcagcag ctgggcgagt gacagccccg gctccgcgcg ccgcggccgc     60

cagagccggc gcaggggaag cgcccgcggc cccgggtgca gcagcggccg ccgcctcccg    120

cgcctccccg gcccgcagcc cgcggtcccg cggccccggg gccggcacct ctcgggctcc    180

ggctccccgc gcgcaagatg gctgacccgg ctgcggggcc gccgccgagc gagggcgagg    240

agagcaccgt gcgcttcgcc cgcaaaggcg ccctccggca gaagaacgtg catgaggtca    300

agaaccacaa attcaccgcc cgcttcttca agcagcccac cttctgcagc cactgcaccg    360

acttcatctg gggcttcggg aagcagggat tccagtgcca agtttgctgc tttgtggtgc    420

acaagcggtg ccatgaattt gtcacattct cctgccctgg cgctgacaag ggtccagcct    480

ccgatgaccc ccgcagcaaa cacaagttta agatccacac gtactccagc cccacgtttt    540

gtgaccactg tgggtcactg ctgtatggac tcatccacca ggggatgaaa tgtgacacct    600

gcatgatgaa tgtgcacaag cgctgcgtga tgaatgttcc cagcctgtgt ggcacggacc    660

acacggagcg ccgcggccgc atctacatcc aggcccacat cgacagggac gtcctcattg    720

tcctcgtaag agatgctaaa aaccttgtac ctatggaccc caatggcctg tcagatccct    780

acgtaaaact gaaactgatt cccgatccca aaagtgagag caaacagaag accaaaacca    840

tcaaatgctc cctcaaccct gagtggaatg agacatttag atttcagctg aaagaatcgg    900

acaaagacag aagactgtca gtagagattt gggattggga tttgaccagc aggaatgact    960

tcatgggatc tttgtccttt gggatttctg aacttcagaa agccagtgtt gatggctggt   1020

ttaagttact gagccaggag gaaggcgagt acttcaatgt gcctgtgcca ccagaaggaa   1080

gtgaggccaa tgaagaactg cggcagaaat ttgagagggc caagatcagt cagggaacca   1140

aggtcccgga agaaaagacg accaacactg tctccaaatt tgacaacaat ggcaacagag   1200

accggatgaa actgaccgat tttaacttcc taatggtgct ggggaaaggc agctttggca   1260

aggtcatgct ttcagaacga aaaggcacag atgagctcta tgctgtgaag atcctgaaga   1320

aggacgttgt gatccaagat gatgacgtgg agtgcactat ggtggagaag cgggtgttgg   1380

ccctgcctgg gaagccgccc ttcctgaccc agctccactc ctgcttccag accatggacc   1440

gcctgtactt tgtgatggag tacgtgaatg ggggcgacct catgtatcac atccagcaag   1500

tcggccggtt caaggagccc catgctgtat tttacgctgc agaaattgcc atcggtctgt   1560

tcttcttaca gagtaagggc atcatttacc gtgacctaaa acttgacaac gtgatgctcg   1620

attctgaggg acacatcaag attgccgatt ttggcatgtg taaggaaaac atctgggatg   1680

gggtgacaac caagacattc tgtggcactc cagactacat cgcccccgag ataattgctt   1740

atcagcccta tgggaagtcc gtggattggt gggcatttgg agtcctgctg tatgaaatgt   1800

tggctgggca ggcacccttt gaaggggagg atgaagatga actcttccaa tccatcatgg   1860

aacacaacgt agcctatccc aagtctatgt ccaaggaagc tgtggccatc tgcaaagggc   1920

tgatgaccaa acacccaggc aaacgtctgg gttgtggacc tgaaggcgaa cgtgatatca   1980

aagagcatgc atttttccgg tatattgatt gggagaaact tgaacgcaaa gagatccagc   2040

ccccttataa gccaaaagct agagacaaga gagacacctc caacttcgac aaagagttca   2100

ccagacagcc tgtggaactg acccccactg ataaactctt catcatgaac ttggaccaaa   2160

atgaatttgc tggcttctct tatactaacc cagagtttgt cattaatgtg taggtgaatg   2220

caaactccat cgttgagcct ggggtgtaag acttcaagcc aagcgtatgt atcaattcta   2280

gtcttccagg attcacggtg cacatgctgg cattcaacat gtggaaagct tgtcttagag   2340

ggcttttctt tgtatgtgta gcttgctagt ttgttttcta catttgaaaa tgtttagttt   2400

agaataagcg cattatccaa ttatagaggt acaattttcc aaacttccag aaactcatca   2460

aatgaacaga caatgtcaaa actactgtgt ctgataccaa aatgcttcag tatttgtaat   2520

ttttcaagtc agaagctgat gttcctggta aaagttttta cagttattct ataatatctt   2580

ctttgaatgc taagcatgag cgatattttt aaaaattgtg agtaagcttt gcagttactg   2640

tgaactattg tctcttggag gaagtttttt gtttaagaat tgatatgatt aaactgaatt   2700

aatatatgca a                                                        2711


<210>  12
<211>  673
<212>  PRT
<213>  Homo sapiens

<400>  12

Met Ala Asp Pro Ala Ala Gly Pro Pro Pro Ser Glu Gly Glu Glu Ser 
1               5                   10                  15      


Thr Val Arg Phe Ala Arg Lys Gly Ala Leu Arg Gln Lys Asn Val His 
            20                  25                  30          


Glu Val Lys Asn His Lys Phe Thr Ala Arg Phe Phe Lys Gln Pro Thr 
        35                  40                  45              


Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly 
    50                  55                  60                  


Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu 
65                  70                  75                  80  


Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Ala Ser Asp 
                85                  90                  95      


Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Ser Ser Pro 
            100                 105                 110         


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln 
        115                 120                 125             


Gly Met Lys Cys Asp Thr Cys Met Met Asn Val His Lys Arg Cys Val 
    130                 135                 140                 


Met Asn Val Pro Ser Leu Cys Gly Thr Asp His Thr Glu Arg Arg Gly 
145                 150                 155                 160 


Arg Ile Tyr Ile Gln Ala His Ile Asp Arg Asp Val Leu Ile Val Leu 
                165                 170                 175     


Val Arg Asp Ala Lys Asn Leu Val Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Ser Glu Ser 
        195                 200                 205             


Lys Gln Lys Thr Lys Thr Ile Lys Cys Ser Leu Asn Pro Glu Trp Asn 
    210                 215                 220                 


Glu Thr Phe Arg Phe Gln Leu Lys Glu Ser Asp Lys Asp Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Ile Trp Asp Trp Asp Leu Thr Ser Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ser Leu Ser Phe Gly Ile Ser Glu Leu Gln Lys Ala Ser Val Asp 
            260                 265                 270         


Gly Trp Phe Lys Leu Leu Ser Gln Glu Glu Gly Glu Tyr Phe Asn Val 
        275                 280                 285             


Pro Val Pro Pro Glu Gly Ser Glu Ala Asn Glu Glu Leu Arg Gln Lys 
    290                 295                 300                 


Phe Glu Arg Ala Lys Ile Ser Gln Gly Thr Lys Val Pro Glu Glu Lys 
305                 310                 315                 320 


Thr Thr Asn Thr Val Ser Lys Phe Asp Asn Asn Gly Asn Arg Asp Arg 
                325                 330                 335     


Met Lys Leu Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser 
            340                 345                 350         


Phe Gly Lys Val Met Leu Ser Glu Arg Lys Gly Thr Asp Glu Leu Tyr 
        355                 360                 365             


Ala Val Lys Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val 
    370                 375                 380                 


Glu Cys Thr Met Val Glu Lys Arg Val Leu Ala Leu Pro Gly Lys Pro 
385                 390                 395                 400 


Pro Phe Leu Thr Gln Leu His Ser Cys Phe Gln Thr Met Asp Arg Leu 
                405                 410                 415     


Tyr Phe Val Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile 
            420                 425                 430         


Gln Gln Val Gly Arg Phe Lys Glu Pro His Ala Val Phe Tyr Ala Ala 
        435                 440                 445             


Glu Ile Ala Ile Gly Leu Phe Phe Leu Gln Ser Lys Gly Ile Ile Tyr 
    450                 455                 460                 


Arg Asp Leu Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile 
465                 470                 475                 480 


Lys Ile Ala Asp Phe Gly Met Cys Lys Glu Asn Ile Trp Asp Gly Val 
                485                 490                 495     


Thr Thr Lys Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile 
            500                 505                 510         


Ile Ala Tyr Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Phe Gly 
        515                 520                 525             


Val Leu Leu Tyr Glu Met Leu Ala Gly Gln Ala Pro Phe Glu Gly Glu 
    530                 535                 540                 


Asp Glu Asp Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ala Tyr 
545                 550                 555                 560 


Pro Lys Ser Met Ser Lys Glu Ala Val Ala Ile Cys Lys Gly Leu Met 
                565                 570                 575     


Thr Lys His Pro Gly Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg 
            580                 585                 590         


Asp Ile Lys Glu His Ala Phe Phe Arg Tyr Ile Asp Trp Glu Lys Leu 
        595                 600                 605             


Glu Arg Lys Glu Ile Gln Pro Pro Tyr Lys Pro Lys Ala Cys Gly Arg 
    610                 615                 620                 


Asn Ala Glu Asn Phe Asp Arg Phe Phe Thr Arg His Pro Pro Val Leu 
625                 630                 635                 640 


Thr Pro Pro Asp Gln Glu Val Ile Arg Asn Ile Asp Gln Ser Glu Phe 
                645                 650                 655     


Glu Gly Phe Ser Phe Val Asn Ser Glu Phe Leu Lys Pro Glu Val Lys 
            660                 665                 670         


Ser 
    


<210>  13
<211>  8014
<212>  DNA
<213>  Homo sapiens

<400>  13
agctggacga gcggcagcag ctgggcgagt gacagccccg gctccgcgcg ccgcggccgc     60

cagagccggc gcaggggaag cgcccgcggc cccgggtgca gcagcggccg ccgcctcccg    120

cgcctccccg gcccgcagcc cgcggtcccg cggccccggg gccggcacct ctcgggctcc    180

ggctccccgc gcgcaagatg gctgacccgg ctgcggggcc gccgccgagc gagggcgagg    240

agagcaccgt gcgcttcgcc cgcaaaggcg ccctccggca gaagaacgtg catgaggtca    300

agaaccacaa attcaccgcc cgcttcttca agcagcccac cttctgcagc cactgcaccg    360

acttcatctg gggcttcggg aagcagggat tccagtgcca agtttgctgc tttgtggtgc    420

acaagcggtg ccatgaattt gtcacattct cctgccctgg cgctgacaag ggtccagcct    480

ccgatgaccc ccgcagcaaa cacaagttta agatccacac gtactccagc cccacgtttt    540

gtgaccactg tgggtcactg ctgtatggac tcatccacca ggggatgaaa tgtgacacct    600

gcatgatgaa tgtgcacaag cgctgcgtga tgaatgttcc cagcctgtgt ggcacggacc    660

acacggagcg ccgcggccgc atctacatcc aggcccacat cgacagggac gtcctcattg    720

tcctcgtaag agatgctaaa aaccttgtac ctatggaccc caatggcctg tcagatccct    780

acgtaaaact gaaactgatt cccgatccca aaagtgagag caaacagaag accaaaacca    840

tcaaatgctc cctcaaccct gagtggaatg agacatttag atttcagctg aaagaatcgg    900

acaaagacag aagactgtca gtagagattt gggattggga tttgaccagc aggaatgact    960

tcatgggatc tttgtccttt gggatttctg aacttcagaa agccagtgtt gatggctggt   1020

ttaagttact gagccaggag gaaggcgagt acttcaatgt gcctgtgcca ccagaaggaa   1080

gtgaggccaa tgaagaactg cggcagaaat ttgagagggc caagatcagt cagggaacca   1140

aggtcccgga agaaaagacg accaacactg tctccaaatt tgacaacaat ggcaacagag   1200

accggatgaa actgaccgat tttaacttcc taatggtgct ggggaaaggc agctttggca   1260

aggtcatgct ttcagaacga aaaggcacag atgagctcta tgctgtgaag atcctgaaga   1320

aggacgttgt gatccaagat gatgacgtgg agtgcactat ggtggagaag cgggtgttgg   1380

ccctgcctgg gaagccgccc ttcctgaccc agctccactc ctgcttccag accatggacc   1440

gcctgtactt tgtgatggag tacgtgaatg ggggcgacct catgtatcac atccagcaag   1500

tcggccggtt caaggagccc catgctgtat tttacgctgc agaaattgcc atcggtctgt   1560

tcttcttaca gagtaagggc atcatttacc gtgacctaaa acttgacaac gtgatgctcg   1620

attctgaggg acacatcaag attgccgatt ttggcatgtg taaggaaaac atctgggatg   1680

gggtgacaac caagacattc tgtggcactc cagactacat cgcccccgag ataattgctt   1740

atcagcccta tgggaagtcc gtggattggt gggcatttgg agtcctgctg tatgaaatgt   1800

tggctgggca ggcacccttt gaaggggagg atgaagatga actcttccaa tccatcatgg   1860

aacacaacgt agcctatccc aagtctatgt ccaaggaagc tgtggccatc tgcaaagggc   1920

tgatgaccaa acacccaggc aaacgtctgg gttgtggacc tgaaggcgaa cgtgatatca   1980

aagagcatgc atttttccgg tatattgatt gggagaaact tgaacgcaaa gagatccagc   2040

ccccttataa gccaaaagct tgtgggcgaa atgctgaaaa cttcgaccga tttttcaccc   2100

gccatccacc agtcctaaca cctcccgacc aggaagtcat caggaatatt gaccaatcag   2160

aattcgaagg attttccttt gttaactctg aatttttaaa acccgaagtc aagagctaag   2220

tagatgtgta gatctccgtc cttcatttct gtcattcaag ctcaacggct attgtggtga   2280

catttttatg tttttcattg ccaagttgca tccatgtttg attttctgat gagactagag   2340

tgacagtgtt tcagaaccca aatgtcctca ggtagtttgg agcatctcta tgagatggga   2400

ttatgcagat ggcctatgga aaatgcagct gcataattaa cacattatca aagtcctctt   2460

acaatttatt ttccgcagca tgtcagctaa gtagacccaa tggggagaga aaatgcctgc   2520

tttctttccc tctttttctg cactgccata ttcaccccca accatccaat ctgtggataa   2580

ttggatgtta gcggtactct tccacttccg ggcctggagc ttggcttgta tccaagtgta   2640

tggttgcttt gcctaagagg aatccctcta tttcacctgt tctggaggca ccagaccttg   2700

aaaagaacat gctcaaaata aaatgttatc tgttattttt gtaaactcaa agttaagatg   2760

atcaaagttc taaaattcca agaatgtgct tttagacggt ctcaatctaa aagcacttca   2820

aggggtcaaa gggcaaccag cttgggtgct acctcagtgt tgtagtttct gatactttat   2880

gtctttgctc accctcatcc ccaaactact tgaaaagggc atttggcacc actctctgaa   2940

acaacacagt cactctagca aggcccccaa agggccctgg ttttacatta catttcaaac   3000

tttatttgct ttggggtttt gtttctgttg ttgttcaaat gcaaaaaaaa gaaaaaaaaa   3060

gaaaaaaaaa ggtgactcac attgttacac atgctttaaa atatgtattc aaatgttatt   3120

aaccacaatg acgacctgct ttgatttaac caagaagacg gctgcggagc ctagcagact   3180

caggcctgtg ggaatgggat ttgttacaaa tctaggtttg ttactggctt cagaaagcta   3240

attaagtgct ctgaaaaaga caccgtttct tgaaacaaag atggttgtat tcctcacttt   3300

gatgttgttt tgcaagatgt ttgtggaaat gttcatttgt atctggatct ctgttatgtg   3360

ccatttttct tctagcatcg agatacaata aaaaaaaaaa aaaagaaaag aagaagaaat   3420

actatttcaa ggaaaactgc tctttttgag aaacgtggac ctaaactaca aagtgggaac   3480

tgaggaggga actcaggaga aaggaactaa ctgcggagct ttaatcttgg ccccagtgtt   3540

cagccactcg gaggggcggg ggctgtggcc cattcagggg ctgctggtgg gctgtagtgg   3600

ggtgggatga cctggccaga gccaacgagg atactggagc ccaaagtcaa gtttagagac   3660

cagctgggaa cgtgaatggg gctcttgatt ttcttatcaa aatcaccact cctcccagct   3720

tggactaaat attctttcta gcaagcagct ttgtgagctc cctgaagccc aaggaaaccc   3780

ttcggtggga gaaatttcat ttctgtctga gaggattaag gcagcaggtg actccccctc   3840

ctcgcctgcc gtgtcctgct attctcaggc agctctaagg agaattctta tcacagttca   3900

agtgatttcc agaagttcca gggcttctga gagaccatca agggaacttt aacaacttga   3960

caaatgtcct tgaagtaaga tgcctcatct ttagggaaaa atggggtttg gatttctgct   4020

taggcaaagt ctcctgcagt tcatccttct ctgtcctctt cttgcttcag gcttggggac   4080

cgtccctgct gtccccactg tggtggcaat caggacctaa ggtgaagcaa acttgaagtt   4140

ctatctgaca agtttaggca gtaagagaag gagggaaatc ggagcaaagc tccctcactt   4200

tattgttgag aaactggcat ctggaaagag gaaggaattt gcccaaagtc agtcagctgg   4260

gataaaaacc tgggtgtcct gtccagaaag tgcagggtgc tttctgctct gtagcaaggc   4320

agcagacatc tctgagccag gcccaccaac aggcccttat ctggtggttg gatcatgatc   4380

ccattttgct tggacatgct ctcaggaaga taaaaaccat ggagaaacac taggccattg   4440

acaaatgatc tgagacaact ttagaaaaca atgtaggatg aatggaaaga gaaagaaagg   4500

aaagaaagaa gaaaaagaaa gaaggaaaga aagaaagaga aaggaaggaa ggaaagaagg   4560

aaggaaaaga aggaaggaag gaaggaatat agtgttataa atactgcact caacattttc   4620

caaattcttg ccattatttt tcaaaagttt aatagtttgc agaaatagat actcaagcca   4680

aagtctgttt tagagaaact ttccatggaa agtcagaatt tctaccactt ccttttctat   4740

ccacatttcc agtgcagaag aaactgagaa acagagcttt ttgaagagag gacagggcca   4800

tagcaacaag gaccttcttg ggggattaat gggaggtcag tagaattaat aaccctcctt   4860

ggatgagtgc tactgttttc acatggcttc agatgctatc aacctcaaag aaatgatctc   4920

aacagagaag cttattctct cccaacttct acggtaaaat ccaggagtat tttctctggg   4980

gatctgccca caggacaaag tccataaaag caagtcctgt ctggaccatg tggttatctg   5040

aagcattagc catcaccagc acaacaaacg gggcagggct ttccaaggtg gggctggtca   5100

gaagggaatc tttgataaga ggcccacagg cagggaaagc gaaatagggt tgatgagacc   5160

aggggagacc taaaaaaaag gcagctttgt gtcttctagc tccaaatata cctgcctttt   5220

agctcacaca ctgtcctgga gttctcagac ctttaggggc cctaacacag ttcagttcat   5280

acaggggttc aaaagggaca gtggcccatt tgggagacct ttaggatcaa tgggaatcaa   5340

ttccattgtt ttgcctcaga gtaaagtttc tggctcgggg acaattataa gttgcaaaaa   5400

ggatagaggc atatcccaag tcttccttca ttccacaaat aattacaaac aacctactgt   5460

gtgccaggca ctattcttag cactggaaat acactagtga agaagcagat gaggaccctg   5520

tttattgttt ctctccaaga aattctccaa gaatattgtt tcttggagag aaataataaa   5580

taaacaagac aatttctgaa agcaataagt gcaatcaaga taattaaagg atgctaaagt   5640

gtgacttgtg gggattggga gagagatgca cagacaatat taaagaggag gcattcgagc   5700

tttgttgtga acaccggaag taacatgccg agcgcctggg ggatggaaac tcctatagca   5760

ccccacaggc taacagcaag caggacaaga caaaaagggc aggtgggaca tggtagagat   5820

ggaccctacc caggaaacag ctccatcagc atcttagcct gccccactct agccacacat   5880

acccacgtgt gctcctgagt tcagtgtgcc cacctcactc ccacaccctc acatagactt   5940

ggcaagagta aggagggaac tccatagaga cattttacct atctcagggg agcagccaca   6000

aagaagcaag tcttgtaaaa ggtcttttgc aaaggagagt gaacccagca atgagagatc   6060

cttaacagct agtgcccatt agggggctaa acctaaagcc tgggtggtga tggctcaaac   6120

gctaatgagt cagtgaatcc ttaccgaccc cctggccttt ataatctgag gcaactttgg   6180

ctgcagcccg ggaatgtgca gggcactagg gaatacaagg ccttcttccc tggttgtctt   6240

gtaataaaac agccatgggg ttgtccctcc agtccgagag actgtgatga ggcctacata   6300

gcagcgatgt ggtcaggtaa aaatcaggaa cccactgaaa tcttgggcaa gccaccctgc   6360

ctgcttgtgc ctcggttctc tcatatgtca tatataggag gtgaggactc cagctccacc   6420

tgccccaggt gggtgtggtg atgatgagga aagacaagag gcttgcaagg accctgaaga   6480

ggtcggagca tcatacagat tcctttatta gcccacattc tgatgttccc tggtgagact   6540

tgccccaagc aattgctagt aaatgggggt taatttcttc tccacctccc tactgaacaa   6600

aaaaagaaat gccagactta ctaggagaat cgagttgctt tgagtttctt ttgttttgtt   6660

ttgttttgtt ttgttttaag gctcccctta cacaccctcc tttaagcttt gggttttctc   6720

tcttatagtt tgttgacaca tgctaaaaat gtctttggag agaacttctg cctgataaac   6780

acccaattct agactgtggg tggattttcg agctgacggt ggtcaattcc tttcattaag   6840

cagtgatctg atttctccac atggccattc tgccttcttg ggggcagagt agatgggcag   6900

cagttcacct tttcagagaa agaggtcttc tagccacctg ggctgctact gaatggtttt   6960

ctccaggacg ctctacctaa tgattatttc tataacatta agcatggtaa taagtagctt   7020

ccaattcaat tcatcctaaa gccaaagaaa atacagcaac acacacacac acacacacac   7080

acacacacac acacacacac acacaccact ttatggcaat tcttaactga cattcaatga   7140

cttacttctt ttcttagaaa atttccacca catttctatc cccaagccaa catacaatgt   7200

gaaatgaaag ccagtgcgtg gagtgcagct gctaaaaatt ttcagcacag ggctctttct   7260

gactctgctc atgagatggt atcagccacc caatgactgg cgtatcttgg tcctgtgtct   7320

ttcttcttac gctgtgttaa tgtgtttact ttccatttgg cagagagaca agagagacac   7380

ctccaacttc gacaaagagt tcaccagaca gcctgtggaa ctgaccccca ctgataaact   7440

cttcatcatg aacttggacc aaaatgaatt tgctggcttc tcttatacta acccagagtt   7500

tgtcattaat gtgtaggtga atgcaaactc catcgttgag cctggggtgt aagacttcaa   7560

gccaagcgta tgtatcaatt ctagtcttcc aggattcacg gtgcacatgc tggcattcaa   7620

catgtggaaa gcttgtctta gagggctttt ctttgtatgt gtagcttgct agtttgtttt   7680

ctacatttga aaatgtttag tttagaataa gcgcattatc caattataga ggtacaattt   7740

tccaaacttc cagaaactca tcaaatgaac agacaatgtc aaaactactg tgtctgatac   7800

caaaatgctt cagtatttgt aatttttcaa gtcagaagct gatgttcctg gtaaaagttt   7860

ttacagttat tctataatat cttctttgaa tgctaagcat gagcgatatt tttaaaaatt   7920

gtgagtaagc tttgcagtta ctgtgaacta ttgtctcttg gaggaagttt tttgtttaag   7980

aattgatatg attaaactga attaatatat gcaa                               8014


<210>  14
<211>  25
<212>  RNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  14
gaaaguccua gauccacacg caaau                                           25


<210>  15
<211>  25
<212>  RNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  15
gaacaugauc cagaccuaca gcaau                                           25


<210>  16
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  16
tttagcatct cttacgagga caatg                                           25


<210>  17
<211>  19
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  17
gcctgtcatc cctacgtaa                                                  19


<210>  18
<211>  21
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  18
ttacgtaggg atctgacagg c                                               21


<210>  19
<211>  25
<212>  DNA
<213>  Artificial

<220>
<223>  synthetic oligonucleotide

<400>  19
cattgtcctc gtaagagatg ctaaa                                           25


<210>  20
<211>  672
<212>  PRT
<213>  Homo sapiens

<400>  20

Met Ala Asp Val Phe Pro Gly Asn Asp Ser Thr Ala Ser Gln Asp Val 
1               5                   10                  15      


Ala Asn Arg Phe Ala Arg Lys Gly Ala Leu Arg Gln Lys Asn Val His 
            20                  25                  30          


Glu Val Lys Asp His Lys Phe Ile Ala Arg Phe Phe Lys Gln Pro Thr 
        35                  40                  45              


Phe Cys Ser His Cys Thr Asp Phe Ile Trp Gly Phe Gly Lys Gln Gly 
    50                  55                  60                  


Phe Gln Cys Gln Val Cys Cys Phe Val Val His Lys Arg Cys His Glu 
65                  70                  75                  80  


Phe Val Thr Phe Ser Cys Pro Gly Ala Asp Lys Gly Pro Asp Thr Asp 
                85                  90                  95      


Asp Pro Arg Ser Lys His Lys Phe Lys Ile His Thr Tyr Gly Ser Pro 
            100                 105                 110         


Thr Phe Cys Asp His Cys Gly Ser Leu Leu Tyr Gly Leu Ile His Gln 
        115                 120                 125             


Gly Met Lys Cys Asp Thr Cys Asp Met Asn Val His Lys Gln Cys Val 
    130                 135                 140                 


Ile Asn Val Pro Ser Leu Cys Gly Met Asp His Thr Glu Lys Arg Gly 
145                 150                 155                 160 


Arg Ile Tyr Leu Lys Ala Glu Val Ala Asp Glu Lys Leu His Val Thr 
                165                 170                 175     


Val Arg Asp Ala Lys Asn Leu Ile Pro Met Asp Pro Asn Gly Leu Ser 
            180                 185                 190         


Asp Pro Tyr Val Lys Leu Lys Leu Ile Pro Asp Pro Lys Asn Glu Ser 
        195                 200                 205             


Lys Gln Lys Thr Lys Thr Ile Arg Ser Thr Leu Asn Pro Gln Trp Asn 
    210                 215                 220                 


Glu Ser Phe Thr Phe Lys Leu Lys Pro Ser Asp Lys Asp Arg Arg Leu 
225                 230                 235                 240 


Ser Val Glu Ile Trp Asp Trp Asp Arg Thr Thr Arg Asn Asp Phe Met 
                245                 250                 255     


Gly Ser Leu Ser Phe Gly Val Ser Glu Leu Met Lys Met Pro Ala Ser 
            260                 265                 270         


Gly Trp Tyr Lys Leu Leu Asn Gln Glu Glu Gly Glu Tyr Tyr Asn Val 
        275                 280                 285             


Pro Ile Pro Glu Gly Asp Glu Glu Gly Asn Met Glu Leu Arg Gln Lys 
    290                 295                 300                 


Phe Glu Lys Ala Lys Leu Gly Pro Ala Gly Asn Lys Val Ile Ser Pro 
305                 310                 315                 320 


Ser Glu Asp Arg Lys Gln Pro Ser Asn Asn Leu Asp Arg Val Lys Leu 
                325                 330                 335     


Thr Asp Phe Asn Phe Leu Met Val Leu Gly Lys Gly Ser Phe Gly Lys 
            340                 345                 350         


Val Met Leu Ala Asp Arg Lys Gly Thr Glu Glu Leu Tyr Ala Ile Lys 
        355                 360                 365             


Ile Leu Lys Lys Asp Val Val Ile Gln Asp Asp Asp Val Glu Cys Thr 
    370                 375                 380                 


Met Val Glu Lys Arg Val Leu Ala Leu Leu Asp Lys Pro Pro Phe Leu 
385                 390                 395                 400 


Thr Gln Leu His Ser Cys Phe Gln Thr Val Asp Arg Leu Tyr Phe Val 
                405                 410                 415     


Met Glu Tyr Val Asn Gly Gly Asp Leu Met Tyr His Ile Gln Gln Val 
            420                 425                 430         


Gly Lys Phe Lys Glu Pro Gln Ala Val Phe Tyr Ala Ala Glu Ile Ser 
        435                 440                 445             


Ile Gly Leu Phe Phe Leu His Lys Arg Gly Ile Ile Tyr Arg Asp Leu 
    450                 455                 460                 


Lys Leu Asp Asn Val Met Leu Asp Ser Glu Gly His Ile Lys Ile Ala 
465                 470                 475                 480 


Asp Phe Gly Met Cys Lys Glu His Met Met Asp Gly Val Thr Thr Arg 
                485                 490                 495     


Thr Phe Cys Gly Thr Pro Asp Tyr Ile Ala Pro Glu Ile Ile Ala Tyr 
            500                 505                 510         


Gln Pro Tyr Gly Lys Ser Val Asp Trp Trp Ala Tyr Gly Val Leu Leu 
        515                 520                 525             


Tyr Glu Met Leu Ala Gly Gln Pro Pro Phe Asp Gly Glu Asp Glu Asp 
    530                 535                 540                 


Glu Leu Phe Gln Ser Ile Met Glu His Asn Val Ser Tyr Pro Lys Ser 
545                 550                 555                 560 


Leu Ser Lys Glu Ala Val Ser Val Cys Lys Gly Leu Met Thr Lys His 
                565                 570                 575     


Pro Ala Lys Arg Leu Gly Cys Gly Pro Glu Gly Glu Arg Asp Val Arg 
            580                 585                 590         


Glu His Ala Phe Phe Arg Arg Ile Asp Trp Glu Lys Leu Glu Asn Arg 
        595                 600                 605             


Glu Ile Gln Pro Pro Phe Lys Pro Lys Val Cys Gly Lys Gly Ala Glu 
    610                 615                 620                 


Asn Phe Asp Lys Phe Phe Thr Arg Gly Gln Pro Val Leu Thr Pro Pro 
625                 630                 635                 640 


Asp Gln Leu Val Ile Ala Asn Ile Asp Gln Ser Asp Phe Glu Gly Phe 
                645                 650                 655     


Ser Tyr Val Asn Pro Gln Phe Val His Pro Ile Leu Gln Ser Ala Val 
            660                 665                 670         


<210>  21
<211>  2019
<212>  DNA
<213>  Homo sapiens

<400>  21
atggctgacg ttttcccggg caacgactcc acggcgtctc aggacgtggc caaccgcttc     60

gcccgcaaag gggcgctgag gcagaagaac gtgcacgagg tgaaggacca caaattcatc    120

gcgcgcttct tcaagcagcc caccttctgc agccactgca ccgacttcat ctgggggttt    180

gggaaacaag gcttccagtg ccaagtttgc tgttttgtgg tccacaagag gtgccatgaa    240

tttgttactt tttcttgtcc gggtgcggat aagggacccg acactgatga ccccaggagc    300

aagcacaagt tcaaaatcca cacttacgga agccccacct tctgcgatca ctgtgggtca    360

ctgctctatg gacttatcca tcaagggatg aaatgtgaca cctgcgatat gaacgttcac    420

aagcaatgcg tcatcaatgt ccccagcctc tgcggaatgg atcacactga gaagaggggg    480

cggatttacc taaaggctga ggttgctgat gaaaagctcc atgtcacagt acgagatgca    540

aaaaatctaa tccctatgga tccaaacggg ctttcagatc cttatgtgaa gctgaaactt    600

attcctgatc ccaagaatga aagcaagcaa aaaaccaaaa ccatccgctc cacactaaat    660

ccgcagtgga atgagtcctt tacattcaaa ttgaaacctt cagacaaaga ccgacgactg    720

tctgtagaaa tctgggactg ggatcgaaca acaaggaatg acttcatggg atccctttcc    780

tttggagttt cggagctgat gaagatgccg gccagtggat ggtacaagtt gcttaaccaa    840

gaagaaggtg agtactacaa cgtacccatt ccggaagggg acgaggaagg aaacatggaa    900

ctcaggcaga aattcgagaa agccaaactt ggccctgctg gcaacaaagt catcagtccc    960

tctgaagaca ggaaacaacc ttccaacaac cttgaccgag tgaaactcac ggacttcaat   1020

ttcctcatgg tgttgggaaa ggggagtttt ggaaaggtga tgcttgccga caggaagggc   1080

acagaagaac tgtatgcaat caaaatcctg aagaaggatg tggtgattca ggatgatgac   1140

gtggagtgca ccatggtaga aaagcgagtc ttggccctgc ttgacaaacc cccgttcttg   1200

acgcagctgc actcctgctt ccagacagtg gatcggctgt acttcgtcat ggaatatgtc   1260

aacggtgggg acctcatgta ccacattcag caagtaggaa aatttaagga accacaagca   1320

gtattctatg cggcagagat ttccatcgga ttgttctttc ttcataaaag aggaatcatt   1380

tatagggatc tgaagttaga taacgtcatg ttggattcag aaggacatat caaaattgct   1440

gactttggga tgtgcaagga acacatgatg gatggagtca cgaccaggac cttctgtggg   1500

actccagatt atatcgcccc agagataatc gcttatcagc cgtatggaaa atctgtggac   1560

tggtgggcct atggcgtcct gttgtatgaa atgcttgccg ggcagcctcc atttgatggt   1620

gaagatgaag acgagctatt tcagtctatc atggagcaca acgtttccta tccaaaatcc   1680

ttgtccaagg aggctgtttc tgtctgcaaa ggactgatga ccaaacaccc agccaagcgg   1740

ctgggctgtg ggcctgaggg ggagagggac gtgagagagc atgccttctt ccggaggatc   1800

gactgggaaa aactggagaa cagggagatc cagccaccat tcaagcccaa agtgtgtggc   1860

aaaggagcag agaactttga caagttcttc acacgaggac agcccgtctt aacaccacct   1920

gatcagctgg ttattgctaa catagaccag tctgattttg aagggttctc gtatgtcaac   1980

ccccagtttg tgcaccccat cttacagagt gcagtatga                          2019


